gebhart/patrepeval huggingface dataset:
Inflammation as a Cardiovascular Risk Factor (2004)

Inflammation occurs in the vasculature as a response to injury, lipid peroxidation, and perhaps infection. Various risk factors, including hypertension, diabetes, and smoking, are amplified by the harmful effects of oxidized low-density-lipoprotein cholesterol, initiating a chronic inflammatory reaction, the result of which is a vulnerable plaque, prone to rupture and thrombosis. Epidemiological and clinical studies have shown strong and consistent relationships between markers of inflammation and risk of future cardiovascular events. Inflammation can potentially be detected locally by imaging techniques as well as emerging techniques, such as identification of temperature or pH heterogeneity. It can be detected systemically by measurement of inflammatory markers. Of these, the most reliable and accessible for clinical use is currently high-sensitivity C-reactive protein. A combination of methods may provide the best identification of persons at risk for cardiovascular events who would benefit from treatment. In randomized, controlled trials, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, in the form of statins, have been shown to provide effective therapy for lowering CRP, in conjunction with their lipid-lowering effects. Although the magnitude of risk reduction associated with statin use appears to be largest for those with the highest serum levels of CRP, whether CRP reduction per se lowers cardiovascular risk is unknown.
Inhibition of all‐Trans‐retinoic acid‐induced proteasome activation potentiates the differentiating effect of retinoid in acute myeloid leukemia cells (2010)

All-trans retinoic acid (ATRA) is nowadays considered to be the sole efficient agent for differentiation-based therapy in leukemia; however, the mechanisms of ATRA's biological effects remain largely unknown. Here we first reported that ATRA-induced myeloid leukemia differentiation was accompanied with the increased level of ubiquitin-protein conjugates and the upregulation of proteasome activity. To explore the functional role of the activated proteasome in retinoic acid (RA) signaling, the effects of proteasome inhibitors on RA-induced cell differentiation were determined. Our results demonstrated that inhibition of ATRA-elevated proteasome activity obviously promoted the myeloid maturation program triggered by ATRA, suggesting that the overactivated proteasome is not beneficial for ATRA's effects. Further studies demonstrated that the synergistic differentiating effects of ATRA and proteasome inhibitors might be associated with the protection of retinoic acid receptor alpha (RARα) from degradation by the ubiquitin-proteasome pathway (UPP). Moreover, the accumulated RARα was able to enhance the transcription of its target gene, which might also contribute to the enhanced differentiation of leukemia cells. Together, by linking the UPP to ATRA-dependent signaling, our data provide a novel insight into studying the mechanisms of ATRA-elicited cellular effects and imply the possibility of combination of ATRA and proteasome inhibitors in leukemia therapy.
ChemInform Abstract: RING CONTRACTION OF HOMOPORPHYRINS TO PORPHYRINS. MESO‐REACTIVITY OF 5,10,15‐TRIPHENYLPORPHIN AND PORPHIN (1978)

Abstract Die Metallierung der Base (I) mit Co(II) liefert die beiden Ringkontraktionsprodukte (IIa).
Targeting the Kinesin Eg5 to Monitor siRNA Transfection in Mammalian Cells (2002)

RNA interference, the inhibition of gene expression by double-stranded RNA, provides a powerful tool for functional studies once the sequence of a gene is known. In most mammalian cells, only short molecules can be used because long ones induce the interferon pathway. With the identification of a proper target sequence, the penetration of the oligonucleotides constitutes the most serious limitation in the application of this technique. Here we show that a small interfering RNA (siRNA) targeting the mRNA of the kinesin Eg5 induces a rapid mitotic arrest and provides a convenient assay for the optimization of siRNA transfection. Thus, dose responses can be established for different transfection techniques, highlighting the great differences in response to transfection techniques of various cell types. We report that the calcium phosphate precipitation technique can be an efficient and cost-effective alternative to Oligofectamine in some adherent cells, while electroporation can be efficient for some cells growing in suspension such as hematopoietic cells and some adherent cells. Significantly, the optimal parameters for the electroporation of siRNA differ from those for plasmids, allowing the use of milder conditions that induce less cell toxicity. In summary, a single siRNA leading to an easily assayed phenotype can be used to monitor the transfection of siRNA into any type of proliferating cells of both human and murine origin.
Infection of Mouse Liver by Human Adenovirus Type 5 (1978)

CBA mice, inoculated intravenously with large doses of adenovirus type 5, showed raised levels of serum aspartate aminotransferase (SAAT; EC 2.6.I.I) and died within a few days from histologically demonstrable hepatic necrosis. After inoculation of I LD50, virus was rapidly taken up by the tissues where infectivity then declined greatly. Organ titres then increased about 100-fold by 48 h p.i. but, in the liver, which showed intranuclear inclusion bodies, and by electron microscopy, scattered intranuclear and intracytoplasmic adenovirions, the increase was 10000- to 100000-fold. P antigen was detected by single radial diffusion in liver extracts, and by immunofluorescence in 80% of liver cells at 36 h p.i. Hexon, penton base and fibre antigens appeared later and in fewer cells. The maximum amount of hexon, of demonstrable type 5 specificity, was shown by radioimmunoassay to be equivalent to up to 5 x 1011 whole adenovirions/g liver. It is concluded that human adenovirus type 5 undergoes an abortive but lytic infection in most liver cells but that replication may proceed to completion in a few.
Strategies for Delivery of Peptides Utilizing Absorption-Enhancing Agents (1996)

The development of oral formulations for the effective delivery of peptides and proteins has been an elusive target. Although some success has been achieved (e.g., with cyclosporine), progress has been slow compared with what has been achieved with more traditional, organic drug molecules. Poor membrane permeability, enzymatic instability, and large molecular size are three factors that have remained major hurdles for peptide formulators. Absorption-enhancing agents that have been effective, at least in research environments, with smaller drug candidates, have also shown some limited efficacy in small animal models with certain peptides. In most cases, however, effective formulations have only achieved fairly low peptide absorption (< 10%) and have also resulted in significant alterations in the normal cellular morphology of the gastrointestinal tract, at least on a transient basis. Both literature and current data are reviewed in this report. Taken as a whole, the data suggest that the successful development of oral peptide formulations remains a significant challenge. Where successes are achieved, they will most likely be on a case-by-case basis and will reflect a balance between absorption-promoting efficacy of the formulation and the extent to which transient alteration of cell or tissue morphology occurs.
Migrating enterprise storage to SSDs: analysis of tradeoffs (2008)

Recently, flash-based solid-state drives (SSDs) have becom e standard options for laptop and desktop storage, but their impact on enterprises has not been studied. Provisioning enterprise storage is challenging. It requires optimizing for the performance, capacity, power and reliability needs of the expected workload, all while minimizing financial costs. This paper, through analysis of a number of enterprise workloads, provides insights as to when, and how, SSDs should be incorporated into the enterprise storage hierarc hy. We describe an automated tool that, given device models and a block-level trace of a workload, determines the least-cost storage configuration. It analyzes the factors that drive th e configuration choice, and computes the price points at which different SSD-based solutions will become cost-effective. Our optimization framework is flexible and can be used to design a range of storage hierarchies. When applied to current workloads and prices we find the following in a nutshell: for many enterprise workloads capacity dominates provisioning costs and the current per-gigabyte price of SSDs is between a factor of 3 and 3000 times higher than needed to be cost-effective for full replacement. We find that SSDs can provide some benefit as an intermediate tier for caching and write-ahead logging in a hybrid disk-SSD configuration. Surprisingly, the power savings achieved by SSDs are comparable to power savings from using low-power SATA disks.
Binding of Clostridium botulinum type B toxin to rat brain synaptosome (1990)

Purified toxin and its subunits from Clostridium botulinum type B were labeled with 125iodine and binding of them to rat brain synaptosomes was studied. Labeled toxin and heavy chain were shown to bind to synaptosomes and there was no significant difference in the molar quantity of bound toxin and heavy chain at several concentrations of synaptosomes, whereas labeled light chain did not bind to synaptosomes. The binding of labeled heavy chain to synaptosomes was inhibited by unlabeled toxin and heavy chain to a similar degree as that of labeled toxin. The binding of labeled toxin and heavy chain to synaptosomes were inhibited by a monoclonal antibody which is specific for the heavy chain.
Dual-color polymer light-emitting pixels processed by hybrid inkjet printing (1998)

A hybrid inkjet printing (HIJP) technology, which combines a pin-hole free polymer buffer layer and an inkjet printed polymer layer, allows the patterning of high quality polymer light-emitting devices. In this letter, we present a successful demonstration of controllable patterning of dual-color polymer light-emitting pixels using this HIJP technique. In this demonstration, the polymer buffer layer is a wide band gap, blue emitting semiconducting polymer prepared by the spin-casting technique. The inkjet printed layer is a red-orange semiconducting polymer which was printed onto the buffer layer. When a proper solvent was selected, the printed polymer diffused into the buffer layer and efficient energy transfer took place generating a red-orange photoluminescence and electroluminescence from the inkjet printed sites. Based on this principle, blue and orange-red dual-color polymer light-emitting pixels were fabricated on the same substrate. The use of this concept represents an entirely new technology for fabricating polymer multicolor displays with high-resolution, lateral patterning capability.
MySQL Bible (2002)

From the Publisher:

Organization: The book is divided into five parts: Getting Starated with MySQL and Relational Databases; Understanding SQL Through MySQL; MySQL Administration; MySQL Developer Guide; and Advanced and Specialized MySQL Topics.
Comprehensive coverage: This Bible covers both beginning-level and advanced topics. Topics covered include: introduction to relational database management; installing and configuring MySQL on the Linux, Windows 2000, and Mac OS X operating systems; MySQL security; debugging and repairing MySQL databases and servers; MySQL performance tuning; and developing MySQL applications with Perl and PHP.
Coverage of NuSphere MySQL: Due to the growing popularity of the NuSphere MySQL package, this book covers its enhancements and how to install and develop with NuSphere MySQL.
Running database application: This book builds an e-commerce sample database application throughout to demonstrate concepts and topics.


ABOUT THE CD-ROM:

What's on the CD-ROM: The CD-ROM includes the latest version of MySQL (either Version 4.0 or 4.1); sample database application and code in the book; and PHP and Perl.
Author Biography: Steve Suehring (Stevens Point, Wisconsin) is currently a Systems Engineer at CoreComm, a 350,000-user Internet Provider. In addition to his other responsibilities, Steve maintains authentication infrastructure using MySQL as the database backend. Steve has built numerous applications with both the Oracle and MySQL databases. He is a Microsoft Certified Systems Engineer, Cisco Certified Design Associate, and Cisco Certified NetworkProfessional. Steve has also written articles for Linux Magazine.
The Flask Security Architecture: System Support for Diverse Security Policies (2006)

Operating systems must be flexible in their support for security policies, providing sufficient mechanisms for supporting the wide variety of real-world security policies. Such flexibility requires controlling the propagation of access rights, enforcing fine-grained access rights and supporting the revocation of previously granted access rights. Previous systems are lacking in at least one of these areas. In this paper we present an operating system security architecture that solves these problems. Control over propagation is provided by ensuring that the security policy is consulted for every security decision. This control is achieved without significant performance degradation through the use of a security decision caching mechanism that ensures a consistent view of policy decisions. Both fine-grained access rights and revocation support are provided by mechanisms that are directly integrated into the service-providing components of the system. The architecture is described through its prototype implementation in the Flask microkernel-based operating system, and the policy flexibility of the prototype is evaluated. We present initial evidence that the architecture's impact on both performance and code complexity is modest. Moreover, our architecture is applicable to many other types of operating systems and environments.
Combined Carbon Dioxide and High Pressure Inactivation of Pectin Methylesterase, Polyphenol Oxidase, Lactobacillus plantarum and Escherichia coli (2002)

ABSTRACT: High pressure processing (HPP) and CO 2 have both been shown to increase food product shelf‐life. CO 2 was added at approximately 0.2 molar % to solutions processed at 500 to 800 MPa in order to further inactivate pectin methylesterase (PME), polyphenol oxidase (PPO), L. plantarum ATCC 8014, and E. coli K12. An interaction was found between CO 2 and pressure at 25 °C and 50 °C for PME and PPO, respectively. Activity of PPO was decreased by CO 2 at all pressure treatments. The interaction between CO 2 and pressure was significant for L. plantarum with a significant decrease in survivors due to the addition of CO 2 at all pressures studied. No significant effect on E. coli survivors was seen with CO 2 addition.
The effect of heat and moisture exchanger and gas flow on humidity and temperature in a circle anaesthetic system. (2002)

This suggests that the inherent humidifying property of the circle system at low fresh gas flow of 1L/min was sufficient in short surgeries lasting less than one hour and that the addition of a HME may not be necessary.
Low Temperature Implementation of Dopant-Segregated Band-edge Metallic S/D junctions in Thin-Body SOI p-MOSFETs (2007)

This paper proposes the implementation of a dopant segregated band-edge silicide using implantation-to-silicide and low temperature activation (500degC). The integration of platinum silicide coupled to boron segregation demonstrates a 50% enhancement of the current drive over the dopant-free approach. RF characterization unveils a cut-off frequency f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> of 180 GHz at L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> =30 nm without application of channel stressors.
Involvement of Rho-Kinase–Mediated Phosphorylation of Myosin Light Chain in Enhancement of Cerebral Vasospasm (2000)

Subarachnoid hemorrhage (SAH) often induces a long-term narrowing of the cerebral artery called cerebral vasospasm. Myosin light chain (MLC) in the spastic basilar artery was reported previously to be phosphorylated by Ca(2+)/calmodulin-dependent MLC kinase. Because Rho-kinase, which is activated by the small GTPase Rho, phosphorylates not only MLC but also myosin phosphatase at its myosin-binding subunit (MBS), thus inactivating myosin phosphatase, we examined whether Rho-kinase is involved in the development of vasospasm. Cerebral vasospasm was produced in the canine basilar artery by a 2-hemorrhage method, and vasocontractions were induced by topical application of 80 mmol/L KCl or 0.5 micromol/L serotonin to the canine basilar artery exposed transclivally. The phosphorylation of MLC in the basilar artery was increased concurrently with an enhancement in the intensity of vasospasm with the passage of time after SAH. In addition, Rho-kinase in the basilar artery was activated concurrently with an increase in the phosphorylation of MBS at Ser854 in vasospasm. The Rho-kinase activation levels in vasospasm on days 0 and 2 were comparable to those in KCl- and serotonin-induced sustained vasocontraction, respectively, and those in vasospasm on day 7 were markedly high. The topical application of Y-27632, a specific inhibitor of Rho-kinase, to the exposed spastic basilar artery on day 7 induced a dose-dependent dilation, and the intensities of vasospasm and the phosphorylation of MBS and MLC were simultaneously decreased by 10 micromol/L Y-27632, although the decrease in MBS phosphorylation was more marked than the decrease in MLC phosphorylation. These results indicate that the activation of Rho-kinase and the phosphorylation of MLC and MBS occur concomitantly during vasospasm induced by SAH and suggest that Rho-kinase is involved in the enhancement of cerebral vasospasm in addition to Ca(2+)/calmodulin-dependent MLC kinase by increasing the phosphorylation of MLC directly or indirectly as a result of the inhibition of myosin phosphatase by its phosphorylation.
Diode-Laser Sensors for Real-Time Control of Pulsed Combustion Systems (1999)

A diode-laser based, closed-loop control system has been developed to nonintrusively optimize a pulsed, 50-kW dump combustor. The adaptive control system used temperature and water mole fraction measurements obtained at 10-kHz rates from the peak absorbance values of H 2 O features near 1.4 μm. In addition, measurements of CO, C 2 H 2 , and C 2 H 4 concentrations in the exhaust, determined from diode-laser absorption spectra recorded using a fast-sampling probe and a multipass absorption cell (nominal 33-m-long path), were used to evaluate the effectiveness of the control strategies. A correlation was established between the magnitude of the observed temperature oscillations and the measured CO concentration in the exhaust. Adaptive control strategies were then applied to maximize the coherence of the burning vortices in the combustion region and thus optimize the combustor performance. The closed-loop control system was able to adaptively tune the phase and amplitude of the applied forcing within 100 ms and the forcing frequency within 10 s. These results demonstrate the applicability of multiplexed diode-laser absorption sensors for rapid, continuous measurements and control of multiple flowfield parameters, including trace species concentrations, in high-temperature combustion environments.
Convergence analyses and comparisons of Markov chain Monte Carlo algorithms in digital communications (2002)

Markov chain Monte Carlo (MCMC) methods have been applied to the design of blind Bayesian receivers in a number of digital communications applications. The salient features of these MCMC receivers include the following: (a) they are optimal in the sense of achieving minimum symbol error rate; (b) they do not require knowledge of the channel states, nor do they explicitly estimate the channel by employing training signals or decision-feedback; and (c) they are well suited for iterative (turbo) processing in coded systems. We investigate the convergence behavior of several MCMC algorithms (both existing and new ones) in digital communication applications. The geometric convergence property of these algorithms is established by considering only the chains or the marginal chains corresponding to the transmitted digital symbols, which take values from a finite discrete set. We then focus on three specific applications, namely, the MCMC decoders in AWGN channels, ISI channels, and CDMA channels. The convergence rates for these algorithms are computed for small simulated datasets. Different convergence behaviors are observed. It is seen that differential encoding, parameter constraining, collapsing, and grouping are efficient ways of accelerating the convergence of the MCMC algorithms, especially in the presence of channel phase ambiguity.
Multiblock PLS analysis of an industrial pharmaceutical process (2002)

The performance of an industrial pharmaceutical process (production of an active pharmaceutical ingredient by fermentation, API) was modeled by multiblock partial least squares (MBPLS). The most important process stages are inoculum production and API production fermentation. Thirty batches (runs) were produced according to an experimental planning. Rather than merging all these data into a single block of independent variables (as in ordinary PLS), four data blocks were used separately (manipulated and quality variables for each process stage). With the multiblock approach it was possible to calculate weights and scores for each independent block. It was found that the inoculum quality variables were highly correlated with API production for nominal fermentations. For the nonnominal fermentations, the manipulations of the fermentation stage explained the amount of API obtained (especially the pH and biomass concentration). Based on the above process analysis it was possible to select a smaller set of variables with which a new model was built. The amount of variance predicted of the final API concentration (cross-validation) for this model was 82.4%. The advantage of the multiblock model over the standard PLS model is that the contributions of the two main process stages to the API volumetric productivity were determined.
Neurotransmitter Control of Secretion (1987)

It is very well established that the principal control of salivary secretion is derived from autonomic innervation. Transmission of a neural signal to a salivary gland acinar cell occurs chemically via neurotransmitters, the first messengers of a secretory response. Neurotransmitters bind to specific cell surface receptor proteins, an event which activates precise transduction mechanisms which then transfer the neural signal to the inside of the cell. There are two major transduction mechanisms operative in salivary gland acinar cells. One involves the generation of cAMP, the other involves the breakdown of plasma membrane polyphosphoinositides. For both mechanisms, the appropriate stimulated receptor activates a second plasma membrane protein, termed an N (or G) protein. The N protein requires GTP to activate an enzyme (adenylate cyclase or phospholipase C), which then catalyzes the formation of a second messenger (cAMP and inositol trisphosphate/diacylglycerol, respectively). This action provides the intracellular signal for secretory events (protein, fluid, electrolyte secretion) to begin.