gebhart/patrepeval huggingface dataset:
SCI for Local Area Networks (1998)

We show how the traditional protocol stack, such as TCP/IP, can be eliminated for socket based high speed communication within a cluster. The SCI shared memory interconnect is used as an example, and we demonstrate how existing applications can utilize the new technology without relinking. This is done by dynamically remapping the TCP/IP socket implementation to our high performance SCILAN sockets. We describe a novel mechanism for synchronization of communication through shared memory, aimed at minimizing the interrupt load on the receiving system. We discuss the implementation and present an evaluation with comparison to alternative technologies, such as 100baseT and ATM. Significant improvement over current solutions are shown both in terms of throughput and latency.
Novel Forms of B‐Domain‐Deleted Recombinant Factor VIII Molecules (1995)

Recombinant molecules similar to the smallest active plasma-derived factor VIII molecule, a complex of an 80-kDa and a 90-kDa polypeptide chain lacking the B domain, have been produced using various factor VIII cDNA constructs in order to obtain primary translation products which were efficiently processed into the 80 + 90-kDa complex. Three types of single-chain cDNAs encoding B-domain-deleted derivatives factor VIII were designed, taking account of sites at Arg740 and Glu1649, assumed to be important for processing factor VIII. In the type 1 constructs, either Arg747, Arg752, or Arg776 in the N-terminal region of factor VIII B domain was fused to the N-terminus (Glu1649) of the 80-kDa subunit. In the type 2 construct r-VIII SQ, Ser743 was fused to Gln1638, creating a link of 14 amino acids between the C-terminus (Arg740) of the 90-kDa chain and N-terminus of the 80-kDa chain, whereas in type 2 r-VIII RH, Arg747 was fused to His1646. In the type 3 constructs, the B-domain was completely removed or replaced with 1-4 Arg residues. After expression in Chinese hamster ovary cells, the type 1 derivatives and the type 3 derivatives with 0-2 Arg residues inserted were found to be only partially processed and contained a large amount of the 170-kDa primary translation product. In contrast, most of the type 2 derivatives r-VIII SQ and r-VIII RH and the type 3 derivatives r-VIII R4 and r-VIII R5 containing three or four extra Arg residues preceding the N-terminus of the 80-kDa chain were processed into the desired 80 + 90-kDa chain complexes. The feature common to the most efficiently processed factor VIII deletion derivatives was that they contained the recognition motif for proteolytic cleavage by the membrane-bound subtilisin-like protease furin, which is expressed in most types of cells; that is, basic amino acid residues at positions -1 and -4 relative to the cleavage site at Glu1649. Biochemical studies of r-VIII SQ and r-VIII R5, two of the most effectively processed factor VIII derivatives, showed that both proteins had a normal factor VIII cofactor function, and had N- and C-termini of the 80-kDa and 90-kDa chains corresponding to those found in plasma-derived factor VIII.
Tailored Chemosensors for Chloroaromatic Acids Using Molecular Imprinted TiO2Thin Films on Ion-Sensitive Field-Effect Transistors (2000)

The SiO2 gate of an ion-sensitive field-effect transistor, (ISFET), is functionalized with a TiO2 film that includes imprinted molecular sites for 4-chlorophenoxy acetic acid, (1), or 2,4-dichlorophenoxy acetic acid, (2). The functionalized devices that include the imprinted interfaces reveal an impressive selectivity in the sensing of the imprinted substrates Na+ -1 or Na+ -2. The detection limit for Na+ -1 is (5+/-2) x 10(-4) M, which corresponds to 38 mV x dec(-1) in the concentration range of 0.5 to 6 mM. The detection limit for the analysis of Na+ -2 is (1.0+/-0.2) x 10(-5) M, which corresponds to 28 mV dec(-1) in the concentration range 0.1-9.0 mM. The equilibration time of the devices is ca. 5 min.
A model of high-affinity antibody binding to type III group B Streptococcus capsular polysaccharide. (1987)

We recently reported that the single repeating-unit pentasaccharide of type III group B Streptococcus (GBS) capsular polysaccharide is only weakly reactive with type III GBS antiserum. To further elucidate the relationship between antigen-chain length and antigenicity, tritiated oligosaccharides derived from type III capsular polysaccharide were used to generate detailed saturation binding curves with a fixed concentration of rabbit antiserum in a radioactive antigen-binding assay. A graded increase in affinity of antigen-antibody binding was seen as oligosaccharide size increased from 2.6 repeating units to 92 repeating units. These differences in affinity of antibody binding to oligosaccharides of different molecular size were confirmed by immunoprecipitation and competitive ELISA, two independent assays of antigen-antibody binding. Analysis of the saturation binding experiment indicated a difference of 300-fold in antibody-binding affinity for the largest versus the smallest tested oligosaccharides. Unexpectedly, the saturation binding values approached by the individual curves were inversely related to oligosaccharide chain length on a molar basis but equivalent on a weight basis. This observation is compatible with a model in which binding of an immunoglobulin molecule to an antigenic site on the polysaccharide facilitates subsequent binding of antibody to that antigen.
Comparisons Among Two Fertile and Three Male-Sterile Mitochondrial Genomes of Maize (2007)

We have sequenced five distinct mitochondrial genomes in maize: two fertile cytotypes (NA and the previously reported NB) and three cytoplasmic-male-sterile cytotypes (CMS-C, CMS-S, and CMS-T). Their genome sizes range from 535,825 bp in CMS-T to 739,719 bp in CMS-C. Large duplications (0.5-120 kb) account for most of the size increases. Plastid DNA accounts for 2.3-4.6% of each mitochondrial genome. The genomes share a minimum set of 51 genes for 33 conserved proteins, three ribosomal RNAs, and 15 transfer RNAs. Numbers of duplicate genes and plastid-derived tRNAs vary among cytotypes. A high level of sequence conservation exists both within and outside of genes (1.65-7.04 substitutions/10 kb in pairwise comparisons). However, sequence losses and gains are common: integrated plastid and plasmid sequences, as well as noncoding "native" mitochondrial sequences, can be lost with no phenotypic consequence. The organization of the different maize mitochondrial genomes varies dramatically; even between the two fertile cytotypes, there are 16 rearrangements. Comparing the finished shotgun sequences of multiple mitochondrial genomes from the same species suggests which genes and open reading frames are potentially functional, including which chimeric ORFs are candidate genes for cytoplasmic male sterility. This method identified the known CMS-associated ORFs in CMS-S and CMS-T, but not in CMS-C.
Intermittent antegrade/selective cerebral perfusion during circulatory arrest for repair of the aortic arch (1997)

If the aortic arch requires repair or replacement due to an aneurysm or dissection, conventional cardiopulmonary bypass (CPB) is not possible during the period in which the aortic arch is excluded from the circulation. This creates a situation in which there is no cerebral circulation. The brain needs adequate protection from this ischaemic insult. Hypothermic circulatory arrest (HCA), antegrade/selective cerebral perfusion (ASCP) and retrograde cerebral perfusion (RCP) are reported to exhibit their cerebral protective capabilities during procedures involving the aortic arch. HCA can provide adequate protection in procedures of short duration and avoids the complications associated with cerebral perfusion techniques. The main disadvantage of HCA is that the 'safe' duration of circulatory arrest is not clearly defined. Topical cooling of the head may enhance cerebral hypothermia and provide additional protection. If longer periods of circulatory arrest are anticipated or occur unexpectedly, we suggest that ASCP can offer improved cerebral protection by providing adequate brain perfusion and improved cerebral cooling. By using a coronary sinus perfusion catheter as a carotid artery cannula, it is not necessary to snare or clamp the carotid arteries. This technique minimizes the chance of damaging the carotid arteries. In this report, we describe our set-up and ASCP perfusion protocol for the surgical repair of an aortic arch aneurysm.
Bioisosteric Replacements of the Pyrazole Moiety of Rimonabant:  Synthesis, Biological Properties, and Molecular Modeling Investigations of Thiazoles, Triazoles, and Imidazoles as Potent and Selective CB1Cannabinoid Receptor Antagonists (2004)

Series of thiazoles, triazoles, and imidazoles were designed as bioisosteres, based on the 1,5-diarylpyrazole motif that is present in the potent CB(1) receptor antagonist rimonabant (SR141716A, 1). A number of target compounds was synthesized and evaluated in cannabinoid (hCB(1) and hCB(2)) receptor assays. The thiazoles, triazoles, and imidazoles elicited in vitro( )()CB(1) antagonistic activities and in general exhibited considerable CB(1) vs CB(2) receptor subtype selectivities, thereby demonstrating to be cannabinoid bioisosteres of the original diarylpyrazole class. Some key representatives in the imidazole series showed potent pharmacological in vivo activities after oral administration in both a CB agonist-induced hypotension model and a CB agonist-induced hypothermia model. Molecular modeling studies showed a close three-dimensional structural overlap between the key compound 62 and rimonabant. A structure-activity relationship (SAR) study revealed a close correlation between the biological results in the imidazole and pyrazole series.
Optimizing Greenhouse Corn Production: What Is the Best Open Pollination Method? (2010)

This document is one entry in a series of questions and answers originally posted to the Purdue University Department of Horticulture & Landscape Architecture’s Plant Growth Facility Web site (http://www.hort.purdue.edu/hort/facilities/greenhouse/CornMethod.shtml) regarding best practices for corn plant growth in a greenhouse. Controlled studies were conducted with the goals of optimizing growth and yield; developing standardized methodology using readily available commercial materials; and providing recommendations for both high-tech and low-tech facilities. Digital images showing treatment differences are included, as well as statistical analysis of data. A summary of recommendations; materials and methods description; and a reference list are available in separate documents.
Consensus molecular subtype classification of colorectal adenomas (2018)

Consensus molecular subtyping is an RNA expression-based classification system for colorectal cancer (CRC). Genomic alterations accumulate during CRC pathogenesis, including the premalignant adenoma stage, leading to changes in RNA expression. Only a minority of adenomas progress to malignancies, a transition that is associated with specific DNA copy number aberrations or microsatellite instability (MSI). We aimed to investigate whether colorectal adenomas can already be stratified into consensus molecular subtype (CMS) classes, and whether specific CMS classes are related to the presence of specific DNA copy number aberrations associated with progression to malignancy. RNA sequencing was performed on 62 adenomas and 59 CRCs. MSI status was determined with polymerase chain reaction-based methodology. DNA copy number was assessed by low-coverage DNA sequencing (n = 30) or array-comparative genomic hybridisation (n = 32). Adenomas were classified into CMS classes together with CRCs from the study cohort and from The Cancer Genome Atlas (n = 556), by use of the established CMS classifier. As a result, 54 of 62 (87%) adenomas were classified according to the CMS. The CMS3 'metabolic subtype', which was least common among CRCs, was most prevalent among adenomas (n = 45; 73%). One of the two adenomas showing MSI was classified as CMS1 (2%), the 'MSI immune' subtype. Eight adenomas (13%) were classified as the 'canonical' CMS2. No adenomas were classified as the 'mesenchymal' CMS4, consistent with the fact that adenomas lack invasion-associated stroma. The distribution of the CMS classes among adenomas was confirmed in an independent series. CMS3 was enriched with adenomas at low risk of progressing to CRC, whereas relatively more high-risk adenomas were observed in CMS2. We conclude that adenomas can be stratified into the CMS classes. Considering that CMS1 and CMS2 expression signatures may mark adenomas at increased risk of progression, the distribution of the CMS classes among adenomas is consistent with the proportion of adenomas expected to progress to CRC. © 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Nitrite reductase activity is a novel function of mammalian mitochondria (1999)

Nitrite, which is the major stable degradation product of nitric oxide, exists in all tissues capable of nitric oxide synthesis from L-arginine. The present study provides experimental evidence that nitrite in contact with respiring mitochondria accepts reducing equivalents from the ubiquinone cycle of the respiratory chain. Univalent reduction of nitrite was totally inhibited by myxothiazol. We therefore conclude on the involvement of redox cycling that ubisemiquinone is associated with the bc1 complex. Recycling of nitric oxide degradation products via these electron carriers may become a threat to energy-linked respiration since nitric oxide in direct contact with mitochondria was shown to slow the energy-linked respiration down and to trigger a mitochondrial source for superoxide radicals. Until now, the existence of nitrite reductase activity was only demonstrated in plants and bacteria. In addition, the present observation elucidates the existence of a nitric oxide synthase-independent nitric oxide source.
Low power acousto-optic device based on a tapered single-mode fiber (1994)

A new type of fiber acousto-optic device, based on tapered single-mode fiber, is described. Unlike earlier designs, the overlap between the acoustic and optical waves is complete, so very little acoustic power is required. Maximum coupling in an experimental device was attained for an electrical drive power of just 0.5 mW.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Electronic Prescribing System in a Teaching Hospital Ã¢Â?Â? User Satisfactionand Factors Affecting Successful Implementation (2019)

Background: Despite the increasing global trend towards e-prescribing, its impact in India is uncertain. Therefore the factors towards successful implementation of e-prescribing system are worth exploring.<br/><br/>Objectives: To assess physicians and pharmacists’ satisfaction, the factors that determine their satisfaction and perceptions about the advantages and disadvantages of e-prescribing system.<br/><br/>Method: A cross-sectional, anonymous questionnaire survey was administered to physicians and pharmacists. Factors pertaining to reliability, speed, ease of use, adequacy of training and impact on productivity and patient care of the system<br/>were determined. Two-tailed t tests were used to find the differences in satisfaction level. Simple correlation analysis was used to find the relation between factors and satisfaction level.<br/><br/>Results: 389 (57%) physicians and pharmacists responded, of which 323 questionnaires that met inclusion criteria were included for analysis. The users were generally satisfied with e-prescribing system (mean=4.75 on a 7 point scale). The pharmacists were more satisfied than the physicians (95% vs. 75%; p<br/>Conclusion: Overall the users were satisfied with e-prescribing system; however, senior physicians were more dissatisfied than others. The findings have implications for strategic training, development of additional features and optimize use among dissatisfied users.
Transmission of polar substituent effects across the bicyclo[1.1.1]pentane ring system as monitored by19F NMR shifts (2000)

A series of 3-substituted(X)bicyclo[1.1.1]pent-1-yl fluorides (1) together with a more limited series of 3-substituted(X)bicyclo[1.1.1]pent-1-yl trifluorides (4) were synthesized and their 19F and 13C NMR spectra were recorded. Correlation of the 19F substituent chemical shifts (SCS) of 1 against the 19F SCS of 4-substituted(X)bicyclo[2.2.2]oct-1-yl fluorides (5), together with a linear multiple regression analysis of the SCS against polar substituent parameters, provide evidence for the importance of strong electronegativity effects (σχ) in 1. The shift pattern for 3 is also more consistent with a dominant substituent electronegativity influence than an electrostatic field effect (σF). Most importantly, the signs of the 19F SCS of 1 and 4 are diametrically opposed. The origin of the σχ effect in 1 is ascribed to hyperconjugative and homohyperconjugative interactions governing the degree of electron population of the σ* orbital of the C– F bond. By contrast, the perturbation of the fluorine π-electron density appears to be the pertinent molecular parameter in 4. The 1J(C,F) values of 1 were not subject to any sensible empirical analysis. Copyright © 2000 John Wiley & Sons, Ltd.
[Comparison of the metabolism of 2 injectable iron preparations (sorbitol iron and polymaltose iron) with the metabolism of transferrin and hemoglobin iron]. (1976)

Iron distribution in the different organs and chemical compartments of the rat has been studied after intravenous injection of 59Fe-sorbitol (Jectofer-Astra) and 59Fe-polymaltose (Fer Hausmann Lucien) and compared with the metabolism of 59Fe bound to transferrin and to hemoglobin. Both parenteral iron preparations are utilized more slowly than Iron-transferrin. The speed of red cell incorporation of 59Fe from sorbitol is similar to the hemoglobin iron utilization (half incorporation in red cells: 4 to 5 days). Iron polymaltose is much more slowly utilized (half incorporation in the red cells: 13 to 15 days). One third of the 59Fe from sorbitol is eliminated in urine, the remaining iron being taken up to 60% by the liver and to 30% by the bone marrow. It is very quickly catabolized, since as early as the first hour after injection most of the 59Fe is bound to polymaltose till the 14th day. Between the third and fourth week 25% of the 59Fe from polymaltose is found in hemosiderin. These metabolic differences are also found in man: 59Fe from iron sorbitol is found in urine after injection, is mobilized by desferrioxamine after six days, and eliminated through dialysis membranes. On the other hand the 59Fe from polymaltose is slowly but completely utilized and not mobilized by desferrioxamine in the first week after injection. The data give the indications for use and the pharmacokinetics of two forms of parenteral iron and oral preparations in the treatment of iron deficiency.
Activated Dyes as Antitumor Agents (1974)

Journal Article Activated Dyes as Antitumor Agents Get access Thomas J. Dougherty Thomas J. Dougherty Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 4, April 1974, Pages 1333–1336, https://doi.org/10.1093/jnci/52.4.1333 Published: 01 April 1974 Article history Received: 10 December 1973 Accepted: 18 December 1973 Published: 01 April 1974
Molecular Imaging of Prostate Cancer: PET Radiotracers (2012)

In this article, I review the current state of affairs on a range of PET radiotracers for potential use in the imaging evaluation of men with prostate cancer.
In vivoHIV-1 infection of CD45RA+CD4+T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4+T cell decline (2000)

Switch from non-syncytium-inducing (NSI) to syncytium-inducing (SI) HIV type 1 (HIV-1) is associated with accelerated CD4(+) T cell depletion, which might partially be explained by higher virulence of SI variants compared with NSI variants. Because NSI and SI variants use different coreceptors for entry of target cells, altered tropism might offer an explanation for increased pathogenesis associated with SI HIV-1 infection. To investigate whether SI and NSI HIV-1 variants infect different CD4(+) T cell subsets in vivo, the distribution of SI and NSI variants over CD4(+) memory (CD45RA(-)RO(+)) and naive (CD45RA(+)RO(-)) cells was studied by using limiting dilution cultures. In contrast to NSI variants that were mainly present in CD45RO(+) cells, SI variants were equally distributed over CD45RO(+) and CD45RA(+) cells. Infection of memory cells by both NSI and SI HIV-1 and infection of naive cells primarily by SI HIV-1 corresponded closely with the differential cell surface expression of CXCR4 and CCR5. The frequency of SI-infected CD45RA(+) CD4(+) T cells, but not the frequency of NSI- or SI-infected CD45RO(+) CD4(+) T cells, correlated with the rate of CD4(+) T cell depletion. Infection of naive cells by SI HIV-1 may interfere with CD4(+) T cell production and thus account for rapid CD4(+) T cell depletion.
Grating-assisted coupling of terahertz waves into a dielectric waveguide studied by terahertz time-domain spectroscopy (2002)

We report on the efficient coupling of terahertz (THz) waves into a dielectric waveguide by means of a diffraction grating engraved at the top of the waveguide. The waveguide is made of a 201-microm-thick high-resistivity silicon wafer. The transmission of the device, measured versus frequency by terahertz time-domain spectroscopy, shows usual m lines when a frequency component of the THz pulse spectrum satisfies the phase-matching condition and is coupled into the waveguide. The experimental data are well modeled with the differential electromagnetic method to compute the diffraction pattern of the grating device. The dispersion curve of the first four modes of propagation is determined from the frequency position of the m lines recorded for different angles of incidence of the THz beam. The waveguide exhibits a weak group velocity dispersion at high frequencies.
Reduction of LDL Cholesterol by 25% to 60% in Patients With Primary Hypercholesterolemia by Atorvastatin, a New HMG-CoA Reductase Inhibitor (1995)

This 6-week, double-blind clinical trial evaluated lipid parameter responses to different dosages of atorvastatin in patients with primary hypercholesterolemia. Atorvastatin is a new 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor under development. After completing an 8-week placebo-baseline dietary phase, 81 patients were randomly assigned to receive either placebo or 2.5, 5, 10, 20, 40, or 80 mg atorvastatin once daily for 6 weeks. Plasma LDL cholesterol reductions from baseline were dose related, with 25% to 61% reduction from the minimum dose to the maximum dose of 80 mg atorvastatin once a day. Plasma total cholesterol and apo B reductions were also dose related. Previously, reductions in LDL cholesterol of the magnitude observed in this study have been seen only with combination drug therapy. In this study, atorvastatin was well tolerated by hyperlipidemic patients, had an acceptable safety profile, and provided greater reduction in cholesterol than other previously reported HMG-CoA reductase inhibitors.
Special feature: Shopfitting: It's a good fit (2014)

A customised refit is a large investment but will help refresh your offer and increase customer loyalty.