gebhart/patrepeval huggingface dataset:
I-F starting method with smooth transition to EMF based motion-sensorless vector control of PM synchronous motor/generator (2008)

This paper proposes a novel hybrid motion- sensorless control system for permanent magnet synchronous motors (PMSM) using a new robust start-up method called I-f control, and a smooth transition to emf-based vector control. The I-f method is based on separate control of i <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</sub> , i <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">q</sub> currents with the reference currents i <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</sub> * = 0 and i <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">q</sub> * constant, and the reference frequency having ramp variation. This solution allows ultra low- speed sensorless control without initial rotor-position estimation, and without machine parameters identification. A first-order lag compensator is employed to ensure a smooth transition from I-f to emf sensorless vector control when the frequency reaches a certain level, and back. The PMSM rotor position and speed are extracted by using a PLL state-observer from the estimated rotor-flux, which is based on an equivalent integrator in close- loop with a PI speed-adaptive compensator to eliminate dc-offset and phase-delay. Digital simulations for PMSM start-up with full load torque are presented for different initial rotor-positions. The transitions from I-f to emf motion-sensorless vector control and back as well, at very low-speeds, are fully validated by experimental results. This method is suitable for both surface and interior PMSMs, but the paper refers directly only to surface PMSM. Other field of application might be in wind generators safe (faster) self-starting when they are connected to the grid, or moving the rotor a little for inspections/repairs, and for general industrial variable speed drives where slightly hesitant but full- load self-starting is allowable.
Optical proximity communication (2009)

We review 10Gb/sec Optical Proximity Communication realized with packaged chips that carry SOI optical waveguides and reflecting mirrors micromachined in silicon. The high precision chip to chip alignment and placement was enabled by a new packaging concept based on the co-integration of pyramidal pit features defined by anisotropic silicon etch and matching high precision micro-spheres. We support this novel packaging approach with measured optical transmission data and discuss the extent of it towards other applications of Proximity Communication.
The Halogenation of Ethylenes (1937)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Halogenation of EthylenesIrving Roberts and George E. KimballCite this: J. Am. Chem. Soc. 1937, 59, 5, 947–948Publication Date (Print):May 1, 1937Publication History Published online1 May 2002Published inissue 1 May 1937https://pubs.acs.org/doi/10.1021/ja01284a507https://doi.org/10.1021/ja01284a507research-articleACS PublicationsRequest reuse permissionsArticle Views2015Altmetric-Citations208LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Enhanced interferon‐β production by CHO cells through elevated osmolality and reduced culture temperature (2009)

For efficient production of native interferon-beta (IFN-beta) in recombinant CHO cell culture, the IFN-beta molecular aggregation that occurs during culture needs to be minimized. To do so, we investigated the effect of hyperosmolality and hypothermia on IFN-beta production and molecular aggregation in rCHO cell culture. Both hyperosmolality (470 mOsm/kg) and hypothermia (32 degrees C) increased specific native INF-beta productivity q(IFN-beta). Furthermore, they decreased the IFN-beta molecular aggregation, although severe IFN-beta molecular aggregation could not be avoided in the later phase of culture. To overcome growth suppression at hyperosmolality and hypothermia, cells were cultivated in a biphasic mode. Cells were first cultivated at 310 mOsm/kg and 37 degrees C for 2 days to rapidly obtain a reasonably high cell concentration. The temperature and osmolality were then shifted to 32 degrees C and 470 mOsm/kg, respectively, to achieve high q(IFN-beta) and reduced IFN-beta molecular aggregation. Due to the enhanced q(IFN-beta) and delayed molecular aggregation, the highest native IFN-beta concentration achieved on day 6 was 18.03 +/- 0.61 mg/L, which was 5.30-fold higher than that in a control batch culture (310 mOsm/kg and 37 degrees C). Taken together, a combination of hyperosmolality and hypothermia in a biphasic culture is a useful strategy for improved native IFN-beta production from rCHO cells.
Mining Effective Subsequences with Application in Marketing Attribution (2016)

In this paper, we present a new data mining framework for discovering sequence effects. In particular, we focus on the sequences consisting of actions that are taken in chronological order, like sequences of clinical procedures or marketing actions. Each sequence is associated with a binary outcome, a success or a failure. We investigate the hypothesis that certain subsequences of actions contribute to successes, which we call effective subsequences. A generic data mining algorithm for extracting effective subsequences is proposed, which is verified both quantitatively and qualitatively. We experimented our effective subsequence mining algorithm on a real sales opportunity dataset. Based on the subsequence model, a market campaign attribution model is proposed, with application to the same sales dataset.
Targeted Inhibition of the Molecular Chaperone Hsp90 Overcomes ALK Inhibitor Resistance in Non–Small Cell Lung Cancer (2013)

In addition to direct kinase inhibition, pharmacologic blockade of the molecular chaperone Hsp90 is emerging as a promising approach for treating tumors driven by oncogenic rearrangements of ALK. The bioactivity profi le of ganetespib presented here underscores a new therapeutic opportunity to target ALK and overcome multiple mechanisms of resistance in patients with ALK-positive NSCLC.
A Nedd8 conjugation pathway is essential for proteolytic targeting of p27 Kip1 by ubiquitination (2000)

Temporal control of p27(Kip1) (p27) degradation imposes periodicity in its activity during cell cycle progression and its accumulation during cell cycle exit. Degradation of p27 is initiated by phosphorylation of p27 at Thr-187, which marks the protein for ubiquitination by SCF(Skp2) and subsequent proteolysis by the 26S proteasome. Here we show that the p27 ubiquitination activity in cell extracts depends on the presence of the ubiquitin-like protein Nedd8 and enzymes that catalyze Nedd8 conjugation to proteins. Moreover, we show that reconstitution of the p27 ubiquitination activity of recombinant SCF(Skp2) also requires Nedd8 conjugation pathway components. Inactivation of the Nedd8 conjugation pathway by a dominant negative mutant of the Nedd8-conjugating enzyme Nce1/Ubc12 blocks the ubiquitination and degradation of p27 in cell extracts. Consistent with a role in cell-cycle progression, Nedd8 is expressed in proliferating cells and is itself down-regulated upon cellular differentiation. These results suggest that the Nedd8 conjugation pathway may regulate the turnover of p27(Kip1), independently of p27 phosphorylation, and further establishes the identity of protein components involved in p27 ubiquitination. Finally, these findings provide a direct demonstration of a function for Nedd8 in a biological process.
Evidence for roles of radicals in protein oxidation in advanced human atherosclerotic plaque (1998)

Oxidative damage might be important in atherogenesis. Oxidized lipids are present at significant concentrations in advanced human plaque, although tissue antioxidants are mostly present at normal concentrations. Indirect evidence of protein modification (notably derivatization of lysine) or oxidation has been obtained by immunochemical methods; the specificities of these antibodies are unclear. Here we present chemical determinations of six protein-bound oxidation products: dopa, o-tyrosine, m-tyrosine, dityrosine, hydroxyleucine and hydroxyvaline, some of which reflect particularly oxy-radical-mediated reaction pathways, which seem to involve mainly the participation of transition- metal ions. We compared the relative abundance of these oxidation products in normal intima, and in human carotid plaque samples with that observed after radiolytically generated hydroxyl radical attack on BSA in vitro. The close similarities in relative abundances in the latter two circumstances indicate that hydroxyl radical damage might occur in plaque. The relatively higher level of dityrosine in plaque than that observed after radiolysis suggests the additional involvement of HOCl-mediated reactions in advanced plaque.
Experimental autoimmune myositis in SJL/J mice. (1987)

Experimental autoimmune myositis (EAM), was produced in SJL/J mice by injection of an emulsion of crude syngeneic muscle homogenate and complete Freund's adjuvant (CFA). Nearly all injected SJL/J mice showed necrotic muscle fibres associated with infiltrating mononuclear cells, both within the necrotic fibres and in surrounding endomysial connective tissue. The disease in SJL/J mice was confined to skeletal muscle. Eight other mouse strains of different major histocompatibility types, similarly injected, failed to develop EAM. Direct immunofluorescence staining revealed prominent IgG deposition at the muscle cell membrane and in perimysial and endomysial connective tissue. This staining was present in both involved muscle of immunized SJL/J mice as well as in undamaged muscle from other immunized strains. Circulating anti-muscle antibodies as detected by indirect immunofluorescence staining of normal muscle were also present in both SJL/J mice and non-susceptible strains. An enzyme-linked immunosorbent assay (ELISA) was also developed for detection of serum anti-muscle antibody activity. Three strains of mice, including SJL/J, failed to develop significantly elevated anti-muscle antibody activity after injection of muscle and CFA, whereas six other strains that did not demonstrate histological myositis developed a 10- to 20-fold elevation of anti-muscle antibody activity. These results suggest that the ability to produce anti-muscle antibodies after immunization does not determine susceptibility to histological disease. Although EAM has been previously induced in other species, there have not been previous descriptions of this experimental disease in mice. This murine model may provide new insight into the immunopathogenesis of human inflammatory myopathies.
Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle. (1992)

Complexes containing plasmid DNA, transferrin-polylysine conjugates, and polylysine-conjugated peptides derived from the N-terminal sequence of the influenza virus hemagglutinin subunit HA-2 have been used for the transfer of luciferase or beta-galactosidase marker genes to K562 cells, HeLa cells, and BNL CL.2 hepatocytes. These DNA complexes mimic the entry of viruses into cells, as they contain functions for (i) the packaging of the nucleic acid with polylysine, (ii) the attachment to the cell and receptor-mediated endocytosis with transferrin as a ligand, and (iii) the release from endosomes by using membrane-disrupting influenza peptides. The presence of these influenza peptide conjugates in the DNA complexes renders the complexes active in membrane disruption in a liposome leakage assay and results in a substantial augmentation of the transferrin-polylysine-mediated gene transfer.
Apnea and Periodic Breathing during Sleep (1999)

In this issue of the Journal, Javaheri reports on his ongoing studies of periodic breathing during sleep in patients with congestive heart failure.1 Since breathing is usually regular, periodic breathing, with its clusters of breaths separated by intervals of apnea or near-apnea, has fascinated physicians for years.2,3 The pattern of periodic breathing can vary considerably. Cheyne–Stokes respiration is characterized by rhythmic rises and falls in tidal volume and breathing frequency and is usually observed in patients with congestive heart failure.At first, periodic breathing, regardless of the type, was thought to indicate a poor prognosis and to arise from . . .
Protocol wrappers for layered network packet processing in reconfigurable hardware (2002)

A library of layered protocol wrappers processes Internet packets in reconfigurable hardware. Collectively, the wrappers simplify and streamline the implementation of high-level networking functions by abstracting the operation of lower-level packet processing functions. The library synthesizes into field-programmable gate array (FPGA) logic and is utilized in a network platform called the field-programmable port extender (FPX). The library processes asynchronous transfer mode (ATM) cells, ATM adaptation layer 5 (AAL5) frames, Internet protocol (IP) messages, and user datagrarn protocol (UDP) packets directly in hardware. Applications can process data at several layers of the protocol stack using the library of wrappers discussed in this article. Layers are important for networks because they let applications abstract from above and below details of the network protocols. At the lowest layer, networks modify raw data passing between interfaces. At higher levels, the applications process variable length frames or IP packets.A network platform called the field-programmable port extender (FPX) streamlines and simplifies network transmission processing directly in hardware.
Comparative evaluation of the protective effect of immune spleen cells and immune RNA againstPlasmodium berghei (1988)

Earlier studies from this laboratory indicated that passive transfer of viable or frozen-thawed cells from spleens and lymph nodes of immune mice resulted in a significant protective immunity against Plasmodium berghei in syngeneic recipients. To assess whether immune RNA played a role in conferring such protection, experiments were designed wherein immune RNA was isolated from immune monkeys, rats and mice and transferred to normal mice. The effect of transfer was assessed by challenging RNA-primed animals with Plasmodium berghei. Results indicated that immune RNA failed to confer resistance against P. berghei both in syngeneic and in heterologous systems.
FlexiTP: A Flexible-Schedule-Based TDMA Protocol for Fault-Tolerant and Energy-Efficient Wireless Sensor Networks (2008)

FlexiTP is a novel TDMA protocol that offers a synchronized and loose slot structure. Nodes in the network can build, modify, or extend their scheduled number of slots during execution, based on their local information. Nodes wake up for their scheduled slots; otherwise, they switch into power-saving sleep mode. This flexible schedule allows FlexiTP to be strongly fault tolerant and highly energy efficient. FlexiTP is scalable for a large number of nodes because its depth-first-search schedule minimizes buffering, and it allows communication slots to be reused by nodes outside each other's interference range. Hence, the overall scheme of FlexiTP provides end-to-end guarantees on data delivery (throughput, fair access, and robust self-healing) while also respecting the severe energy and memory constraints of wireless sensor networks. Simulations in ns-2 show that FlexiTP ensures energy efficiency and is robust to network dynamics (faults such as dropped packets and nodes joining or leaving the network) under various network configurations (network topology and network density), providing an efficient solution for data-gathering applications. Furthermore, under high contention, FlexiTP outperforms 2-MAC in terms of energy efficiency and network performance.
QuickTree: building huge Neighbour-Joining trees ofprotein sequences (2002)

We have written a fast implementation of the popular Neighbor-Joining tree building algorithm. QuickTree allows the reconstruction of phylogenies for very large protein families (including the largest Pfam alignment containing 27000 HIV GP120 glycoprotein sequences) that would be infeasible using other popular methods.
Treatment With a Novel Hemigramicidin-TEMPO Conjugate Prolongs Survival in a Rat Model of Lethal Hemorrhagic Shock (2007)

These data support the view that mitochondrially targeted electron acceptors and SOD mimics are potentially valuable therapeutics for the treatment of serious acute conditions, such as HS, which are associated with marked tissue ischemia.
Epoxy Resins (2001)

Abstract This article discusses the three basic elements of an epoxy resin formulation that must be understood when selecting a thermoset system. These include base resins, epoxy resin curatives, and modifiers. The article provides examples of epoxy resin formulations that illustrate how raw materials are combined to tailor a formulation to a specific application. It concludes with a discussion on general guidelines for the safe handling of epoxy resins and their associated products.
Quantum stochastic calculus (1987)

Martingales are fundamental stochastic process used to model the concept of fair game. They have a multitude of applications in the real world that include, random walks, Brownian motion, gamblers fortunes and survival analysis, Just as commutative integration theory may be realised as a special case of the more general non-commutative theory for integrals, so too, we find classical probability may be realised as a limiting, special case of quantum probability theory. In this thesis we are concerned with the development of multiparameter quantum stochastic integrals extending non-commutative constructions to the general n parameter case, these being multiparameter quantum stochastic integrals over the positive n dimensional plane, employing martingales as integrator. The thesis extends previous analogues of type one, and type two stochastic integrals, for both Clifford and quasi free representations. As with one and two dimensional parameter sets, the stochastic integrals constructed form orthogonal, centred L2 martingales, obeying isometry properties. We further explore analogues for weakly adapted processes, properties relating to the resulting quantum stochastic integrals, develop analogues to Fubini’s theorem, and explore applications for quantum stochastic integrals in a security setting.
Chemical vapour etching of Si, SiGe and Ge with HCl; applications to the formation of thin relaxed SiGe buffers and to the revelation of threading dislocations (2004)

We have studied the etching of silicon, SiGe and germanium layers with gaseous HCl in reduced pressure-chemical vapour deposition (RP-CVD). We have observed the occurrence of two etch regimes depending on the etching temperature. The first regime takes place at high temperatures and is characterized by low activation energies (∼7 kcal mol−1), this whatever the germanium content of the etched layer. The other regime occurs at low temperatures and has associated high activation energies (which strongly depend upon the germanium concentration of the etched layer: 86 kcal mol−1 for pure Si versus 28 kcal mol−1 for pure Ge). Modifying the HCl partial pressure has different effects depending on the regime. In the high temperature regime, increasing the HCl partial pressure will almost quadratically increase the etch rate (ER ∝ PHCl1.76), this both for Si and Si0.67Ge0.33. Meanwhile, the dependence is sub-linear in the low temperature regime (Si ER ∝ PHCl0.53 and Si0.67Ge0.33 ER ∝ PHCl0.82). The temperature where the regime shifts from one to the other decreases when the Ge concentration increases. To illustrate the added value of the chemical vapour etching, we have demonstrated two possible applications. The first one is the realization of SiGe thin strain relaxed buffers (TSRBs) in the active areas of shallow trench isolation (STI) patterned wafers after etching away the silicon with HCl. We have observed the occurrence of some etching loading effects when moving from a blanket to a patterned wafer. The SiGe TSRBs exhibit some good structural properties (rms roughness of 0.12 nm, no defects observed in cross-sectional transmission electron microscopy). However, they are not fully relaxed and facets are present at the STI/epitaxial stack boundary, signifying they are still not mature enough to be integrated in a metal oxide semiconductor technology. Another possible application is to decorate through some in situ HCl etching the dislocations threading through SiGe relaxed thick layers, with some significant advantages over commonly used wet etching solutions such as the Secco and the Schimmel ones.
Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin, sodium nitrite, and amyl nitrite (1981)

Relaxation by nitroglycerin, sodium nitrite, and amyl nitrite of bovine coronary arterial smooth muscle was inhibited by the oxidant methylene blue. Methylene blue also inhibited activation of bovine coronary arterial soluble guanylate cyclase by nitroglycerin, which required addition of cysteine. At concentrations less than 10 mM, sodium nitrite required the addition of one of several thiols or ascorbate to activate guanylate cyclase from bovine coronary artery. Guanylate cyclase activation by large amounts (50 microL) of saturated amyl nitrite gas did not require, but was enhanced by, the addition of thiols or ascorbate. However, similar to sodium nitrite, guanylate cyclase activation by smaller amounts (5 microL) of saturated amyl nitrite gas did require the addition of one of various thiols or ascorbate. Methylene blue markedly inhibited guanylate cyclase activation by sodium nitrite in the presence of cysteine or ascorbate and similarly inhibited enzyme activation by amyl nitrite either in the absence or presence of cysteine or ascorbate. These data support the hypothesis that nitrates and nitrites relax vascular smooth muscle by stimulating cyclic GMP formation. The results further suggest that, similar to relaxation and guanylate cyclase activation by nitroso-containing compounds, relaxation and enzyme activation by nitrates and and nitrites may involve the formation of nitric oxide or complexes of nitric oxide as active intermediates.
Characterization Of Pigs Transgenic For Human Decay-Accelerating Factor1 (1997)

Transgenic pigs, which express levels of functional HDAF even greater than those observed in humans, have successfully been produced. Pigs transgenic for human complement inhibiting molecules could represent a source of organs for future clinical xenotransplantation.