gebhart/patrepeval huggingface dataset:
Identification of Cyclin B1 as a Shared Human Epithelial Tumor-Associated Antigen Recognized by T Cells (2001)

We eluted peptides from class I molecules of HLA-A2.1(+) breast adenocarcinoma and loaded reverse phase high-performance liquid chromatography (HPLC) fractions onto dendritic cells to prime naive CD8(+) T cells. Fractions that supported growth of tumor-specific cytotoxic T lymphocytes were analyzed by nano-HPLC micro-ESI tandem mass spectrometry. Six HLA-A2.1-binding peptides, four 9-mers (P1-P4) differing in the COOH-terminal residue, and two 10-mers (P5 and P6) with an additional COOH-terminal alanine, were identified in one fraction. Peptide sequences were homologous to cyclin B1. We primed CD8(+) T cells from another HLA-A2.1(+) healthy donor with synthetic peptides and generated P4-specific responses. We also detected memory T cells specific for one or more of these peptides in patients with breast cancer and squamous cell carcinomas of the head and neck (SCCHN). T cells from one patient, restimulated once in vitro, could kill the tumor cell line from which the peptides were derived. Immunohistochemical analysis of tumor lines and tissue sections showed cyclin B1 overexpression and aberrant localization in the cytoplasm instead of the nucleus. Sequencing genomic DNA and cDNA corresponding to P1-P6 region showed that differences in COOH-terminal residues were not due to either DNA mutations or errors in transcription, suggesting a high error rate in translation of cyclin B1 protein in tumors.
Genetics and the Epidemiology of Chronic Diseases. (1965)

"Held ... June 17-19, 1963 and co-sponsored by the Division of Chronic Diseases, U. S. Public Health Service, and the Schools of Medicine and Public Health of the University of Michigan."
Molecular electrostatic potential of the nucleic acids (1981)

It is generally acknowledged that geometrical and conformational properties of biopolymers have an important effect on their biochemical behaviour. It is less easily recognized that these properties depend also on their macromolecular electronic characteristics. The aim of this review is to demonstrate the significance of such macromolecular electronic effects. Particularly useful for this sake is the recently much developed concept of ‘molecular electrostatic potential’ (MEP) (Scrocco &amp; Tomasi, 1973, 1978) by which is defined the electrostatic (Coulomb) potential created in the neighbouring space by the nuclear charges and the eletronic distribution of a molecule.
Sacrococcygeal Rhizotomy for Perineal Pain (1986)

Chronic pain in the perineum is a difficult neurosurgical problem. This article evaluates the effectiveness of sacrococcygeal rhizotomy in 28 patients who had cancer-related pain or coccydynia, underwent rhizotomy, and were followed for an average of 3 years. Good pain relief was obtained in 53% (10 of 19 patients) with malignant pain, as opposed to 22% (2 of 9 patients) with nonmalignant pain. Sacral rhizotomy is a reasonable treatment for cancer-related perineal pain, but it is ineffective for coccydynia and other benign perineal pain problems.
Prodrugs in cancer chemotherapy (1986)

At present, chemotherapy is not very effective against common solid cancers especially once they have metastasised. However, laboratory experiments and studies on dose intensification in humans have indicated that some anti-cancer agents might be curative but only if the dose given was very much higher than that presently obtainable clinically. Prodrugs, activated by enzymes expressed at raised level in tumors, can deliver at least 50-fold the normal dose and can cure animals with tumors normally resistant to chemotherapy. This approach has not yet proved to be practicable clinically because of the rarity of human tumors expressing a high level of an activating enzyme. However, new therapies have been proposed overcome this limitation of prodrug therapy. Enzymes that activate prodrugs can be directed to human tumor xenografts by conjugating them to tumor associated antibodies. After allowing for the conjugate to clear from the blood a prodrug is administered which is normally inert but which is activated by the enzyme delivered to the tumor. This procedure is referred to as ADEPT (antibody-directed enzyme prodrug therapy). Early clinical trials are promising and indicate that ADEPT may become an effective treatment for all solid cancers for which tumor associated or tumor specific antibodies are known. Tumors have also been targeted with the genes encoding for a prodrug activating enzymes. This approach has been called genedirected enzyme prodrug therapy (GDEPT) or VDEPT (virus-directed enzyme prodrug therapy) and has shown good results in animal models. These new therapies may finally realise the potential of prodrugs in cancer chemotherapy.
Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas. (1992)

Our results indicate that the malignant phenotype in human glial tumors is associated with an upregulation of the PDGFR-beta on endothelial cells of vessels which vascularize the tumor. These findings may contribute to our understanding of the mechanisms that regulate vessel growth and differentiation in normal and pathologic states.
On Shape Preserving Quadratic Spline Interpolation (1983)

In this paper we discuss the design of algorithms for interpolating discrete data using $C^1 $-quadratic splines in such a way that the monotonicity and/or convexity of the data is preserved. The analysis culminates in an interactive algorithm which takes full advantage of the flexibility which quadratic splines permit.
Multiple rare earth emissions in a multicore tellurite fiber with a single pump wavelength (2007)

A three-core tellurite glass fiber having different combinations of rare earth oxide dopants in each core has been fabricated using shaped die-extrusion. Three cores, doped with Ho(3+)-Tm(3+)-Yb(3+), Er(3+)-Ce(3+), and Tm(3+)-Yb(3+) respectively, exhibited visible upconversion (blue, green and red) and infrared emissions at 1.4 microm, 1.5 microm, 1.9 microm and 2.05 microm when pumped at a wavelength of 980 nm. The prospects for multi-band amplifiers and lasers are discussed.
Systematic discovery of multicomponent therapeutics (2003)

Multicomponent therapies, originating through deliberate mixing of drugs in a clinical setting, through happenstance, and through rational design, have a successful history in a number of areas of medicine, including cancer, infectious diseases, and CNS disorders. We have developed a high-throughput screening method for identifying effective combinations of therapeutic compounds. We report here that systematic screening of combinations of small molecules reveals unexpected interactions between compounds, presumably due to interactions between the pathways on which they act. Through systematic screening of approximately 120,000 different two-component combinations of reference-listed drugs, we identified potential multicomponent therapeutics, including (i) fungistatic and analgesic agents that together generate fungicidal activity in drug-resistant Candida albicans, yet do not significantly affect human cells, (ii) glucocorticoid and antiplatelet agents that together suppress the production of tumor necrosis factor-alpha in human primary peripheral blood mononu-clear cells, and (iii) antipsychotic and antiprotozoal agents that do not exhibit significant antitumor activity alone, yet together prevent the growth of tumors in mice. Systematic combination screening may ultimately be useful for exploring the connectivity of biological pathways and, when performed with reference-listed drugs, may result in the discovery of new combination drug regimens.
COSI: Cloud Oriented Subgraph Identification in Massive Social Networks (2010)

Subgraph matching is a key operation on graph data. Social network (SN) providers may want to find all subgraphs within their social network that match certain query graph patterns. Unfortunately, subgraph matching is NP-complete, making its application to massive SNs a major challenge. Past work has shown how to implement subgraph matching on a single processor when the graph has 10-25M edges. In this paper, we show how to use cloud computing in conjunction with such existing single processor methods to efficiently match complex subgraphs on graphs as large as 778M edges. A cloud consists of one master compute node and k slave compute nodes. We first develop a probabilistic method to estimate probabilities that a vertex will be retrieved by a random query and that a pair of vertices will be successively retrieved by a random query. We use these probability estimates to define edge weights in an SN and to compute minimal edge cuts to partition the graph amongst k slave nodes. We develop algorithms for both master and slave nodes that try to minimize communication overhead. The resulting COSI system can answer complex queries over real-world SN data containing over 778M edges very efficiently.
Nucleic Acid Concentrations in Normal Human Plasma (1972)

Abstract Utilizing a simple, rapid, and inexpensive modification of a fluorometric method, we determined the normal concentrations of nucleic acids (DNA and RNA) in human blood plasma of healthy individuals. DNA concentrations (13.9 ± 3.7 mg/ liter) were in excellent agreement with those reported by other methods. However, the RNA concentrations (144 ± 22 mg/liter) we found were higher than previously reported values, possibly because ribonuclease activity is more inhibited in this fluorometric method.
A hybrid neural and statistical classifier system for histopathologic grading of prostatic lesions. (1995)

Neural network and statistical classification methods were applied to derive an objective grading for moderately and poorly differentiated lesions of the prostate, based on characteristics of the nuclear placement patterns. A partly trained multilayer neural network was used as a feature extractor. A hybrid classifier system using a quadratic Bayesian classifier applied to these features allowed grade assignment consensus with visual diagnosis in 96% of fields from a training set of 500 fields and in 77% of 130 fields of a test set.
Therapeutic Potential for Inhibition of HIV Activation (2007)

The Human Immunodeficiency Virus (HIV) is as simple as it is successful. Consisting of only relatively few elementary molecules, it is exceedingly hard to detect and has proven both difficult and expensive to treat. Treatment modalities are limited by the simplicity of its life cycle and the already compromised immune systems of patients. Current antiretroviral treatments are reasonably effective, but far too expensive for widespread distribution. Similarly, education can only go so far in combating such a virulent disease that is infectious in the absence of symptoms. This scenario presents an epidemiological dilemma: The highest rates of HIV prevalence are in underdeveloped and uneducated parts of the world. The areas worst afflicted lack the finances and infrastructure to initiate effective treatment programs.&#13;\n&#13;\nThis paper discusses the pathway for activation of the HIV provirus, and proposes the use of inexpensive plant extracts to slow rates of transmission and the progression from HIV infection to AIDS. It also addresses the growing problem of HIV/tuberculosis co-infection and use of combined treatments to slow infection rates of both diseases.
HelpMate to ease hospital delivery and collection tasks, and assist with security (1997)

Obtains the impressions gained ‐ six months into a trial in a UK hospital setting ‐from using the HelpMate robot to transport materials between wards, labs and pharmacy. Shows how the 24 hours a day availability of the robot has prompted further ideas for its use, for instance, security patrolling at night when fitted with closed‐circuit TV. Also discusses the problem areas highlighted in the initial trial period.
Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials (2004)

The marine environment has proven to be a very rich source of extremely potent compounds that have demonstrated significant activities in antitumor, antiinflammatory, analgesia, immunomodulation, allergy, and anti-viral assays. Although the case can and has been made that the nucleosides such as Ara-A and Ara-C are derived from knowledge gained from investigations of bioactive marine nucleosides, no drug directly from marine sources (whether isolated or by total synthesis) has yet made it to the commercial sector in any disease. However, as shown in this review, there are now significant numbers of very interesting molecules that have come from marine sources, or have been synthesized as a result of knowledge gained from a prototypical compound, that are either in or approaching Phase II/III clinical trials in cancer, analgesia, allergy, and cognitive diseases. A substantial number of other potential agents are following in their wake in preclinical trials in these and in other diseases.
Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: Rationale and design of the ODYSSEY Outcomes trial (2014)

ODYSSEY Outcomes will determine whether the addition of the PCSK9 antibody alirocumab to intensive statin therapy reduces cardiovascular morbidity and mortality after ACS.
Analytical Expression of Average Power-Coupling Coefficients for Estimating Intercore Crosstalk in Multicore Fibers (2012)

In order to realize fast and accurate estimation of intercore crosstalk in bent multicore fibers (MCFs), an analytical expression of the average power-coupling coefficient (PCC) based on an exponential autocorrelation function is, for the first time, derived, resulting in no need for heavy numerical computations. It is revealed that, when the bending radius is large and the correlation length is large, the average PCC is inversely proportional to the correlation length and to the square of the propagation constant difference Δβ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">mn</sub> between core m and core n, and when the bending radius is small and the correlation length is large, the average PCC is proportional to the bending radius and is independent of the correlation length. When the correlation length is small, on the other hand, the average PCC is proportional to the correlation length and is independent of the bending radius. For homogeneous MCFs (Δβ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">mn</sub> = 0) with small bending radius, the average PCC coincides with the mean crosstalk increase per unit length derived from the coupled-mode theory of Hayashi et al. that is proportional to the bending radius. Average crosstalk values calculated by using the analytical expression derived here are in excellent agreement with those of numerical solutions of coupled-power equations, irrespective of the values of bending radius and correlation length.
USP8 Is a Novel Target for Overcoming Gefitinib Resistance in Lung Cancer (2013)

Our results show for the first time that the inhibition of USP8 activity or reduction in USP8 expression can selectively kill NSCLC cells. We propose USP8 as a potential therapeutic target for gefitinib-resistant and -sensitive NSCLC cells.
Bolaform amphiphiles with a rigid hydrophobic bixin core in surface monolayers and lipid membranes (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBolaform amphiphiles with a rigid hydrophobic bixin core in surface monolayers and lipid membranesJuergen Hinrich Fuhrhop, Matthias Krull, Andrea Schulz, and Dietmar MoebiusCite this: Langmuir 1990, 6, 2, 497–505Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://pubs.acs.org/doi/10.1021/la00092a034https://doi.org/10.1021/la00092a034research-articleACS PublicationsRequest reuse permissionsArticle Views211Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Potent Inhibition of HIV-1 Replication by Novel Non-peptidyl Small Molecule Inhibitors of Protease Dimerization (2007)

Dimerization of HIV-1 protease subunits is essential for its proteolytic activity, which plays a critical role in HIV-1 replication. Hence, the inhibition of protease dimerization represents a unique target for potential intervention of HIV-1. We developed an intermolecular fluorescence resonance energy transfer-based HIV-1-expression assay employing cyan and yellow fluorescent protein-tagged protease monomers. Using this assay, we identified non-peptidyl small molecule inhibitors of protease dimerization. These inhibitors, including darunavir and two experimental protease inhibitors, blocked protease dimerization at concentrations of as low as 0.01 microm and blocked HIV-1 replication with IC(50) values of 0.0002-0.48 microm. These agents also inhibited the proteolytic activity of mature protease. Other approved anti-HIV-1 agents examined except tipranavir, a CCR5 inhibitor, and soluble CD4 failed to block the dimerization event. Once protease monomers dimerize to become mature protease, mature protease is not dissociated by this dimerization inhibition mechanism, suggesting that these agents block dimerization at the nascent stage of protease maturation. The proteolytic activity of mature protease that managed to undergo dimerization despite the presence of these agents is likely to be inhibited by the same agents acting as conventional protease inhibitors. Such a dual inhibition mechanism should lead to highly potent inhibition of HIV-1.
Depression and sensitization to stressors among young women as a function of childhood adversity. (2000)

The authors tested a stress-sensitization version of a diathesis-stress approach to depression. In a 2-year longitudinal follow-up design, exposure to stressful life events was examined in young women in the transition to adulthood. The authors hypothesized that those who had experienced one or more significant childhood adversities would have a lower threshold for developing a depressive reaction to stressors. Results indicated that women with exposure to one or more childhood adversities--such as family violence, parent psychopathology or alcoholism, and others--were more likely to become depressed following less total stress than women without such adversity. The results could not be accounted for by chronic stress or prior depression. Both biological and psychological sensitization mechanisms may be speculated to play a role, but the actual mechanisms of stress sensitization remain to be explored.
Selective killing of candidate AML stem cells by antibody targeting of IL1RAP (2013)

IL1RAP, a co-receptor for interleukin (IL)-1 and IL-33 receptors, was previously found to be highly upregulated on candidate chronic myeloid leukemia stem cells, allowing for leukemia-selective killing using IL1RAP-targeting antibodies. We analyzed IL1RAP expression in a consecutive series of 29 patients with acute myeloid leukemia (AML) and, based on the level of expression in mononuclear cells (MNCs), we divided the samples into 3 groups: IL1RAP low (n = 6), IL1RAP intermediate (n = 11), and IL1RAP high (n = 12). Within the CD34+CD38- population, the intermediate and high groups expressed higher levels of IL1RAP than did corresponding normal cells. With the aim to target AML stem cells, an anti-IL1RAP monoclonal antibody was generated followed by isotype switching for improved antibody-dependent, cell-mediated cytotoxicity activity. Using this antibody, we achieved selective killing of AML MNC, CD34+CD38+, and CD34+CD38- cells. Our findings demonstrate that IL1RAP is a promising new therapeutic target in AML.
The psychobiology of resilience and vulnerability to anxiety disorders: implications for prevention and treatment (2003)

Much of the research on the neurobiology of human anxiety disorders has focused on psychopaihological abnormalities in patients with anxiety disorders. While this line of research is obviously important, more investigation is needed to elucidate the psychobiology of resilience to extreme stress. Study of the psychobiology of resilience has the potential to identify neurochemical, neuropeptide, and hormonal mediators of vulnerability and resilience to severe stress. In addition, the relevance of neural mechanisms of reward and motivation, fear responsiveness, and social behavior to character traits associated with risk and resistance to anxiety disorders may be clarified. These areas of investigation should lead to improved methods of diagnosis, novel approaches to prevention, and new targets for antianxiety drug discovery.
Increased nutritive value of transgenic potato by expressing a nonallergenic seed albumin gene from Amaranthus hypochondriacus (2000)

Improvement of nutritive value of crop plants, in particular the amino acid composition, has been a major long-term goal of plant breeding programs. Toward this end, we reported earlier the cloning of the seed albumin gene AmA1 from Amaranthus hypochondriacus. The AmA1 protein is nonallergenic in nature and is rich in all essential amino acids, and the composition corresponds well with the World Health Organization standards for optimal human nutrition. In an attempt to improve the nutritional value of potato, the AmA1 coding sequence was successfully introduced and expressed in tuber-specific and constitutive manner. There was a striking increase in the growth and production of tubers in transgenic populations and also of the total protein content with an increase in most essential amino acids. The expressed protein was localized in the cytoplasm as well as in the vacuole of transgenic tubers. Thus we have been able to use a seed albumin gene with a well-balanced amino acid composition as a donor protein to develop a transgenic crop plant. The results document, in addition to successful nutritional improvement of potato tubers, the feasibility of genetically modifying other crop plants with novel seed protein composition.