gebhart/patrepeval huggingface dataset:
Cambios y permanencias en las dinámicas sociodemográficas de los Pirineos españoles. El papel de los movimientos migratorios (2003)

En este trabajo pretendemos ofrecer una vision de conjunto de la demografia de los municipios y comarcas que conforman el espacio que convencionalmente definimos como los Pirineos. Un territorio que, con mayor o menor intensidad segun las coyunturas, ha vislumbrado como sus efectivos poblacionales han ido disminuyendo dramaticamente a lo largo de todo el siglo XX. Un buen ejemplo de ello lo encontramos en que son numerosos los municipios que cuentan con un numero de moradores en el ano 2002 inferior a los contabilizados en el ano 1900, iun siglo antes!. Huelga recordar que este es un proceso de crisis demografica generalizado en las areas de montana de la mayoria de paises desarrollados -y los Pirineos espanoles no son ninguna excepcion-, y que se explica en ultima instancia por la propia logica espacial del capitalismo que ha coadyuvado a una concentracion territorial creciente de poblacion y de actividades economicas.
Increased Levels of Soluble CD14 in Sera of Periodontitis Patients (1999)

Soluble CD14 (sCD14) mediates the response to lipopolysaccharide (LPS) in cells lacking membrane-bound CD14. We determined sCD14 concentrations in the sera of 38 periodontitis patients and 25 healthy controls by enzyme-linked immunosorbent assay. The sCD14 levels in the sera of patients with periodontitis were significantly higher than those of healthy subjects and decreased after treatment. Enhanced levels of sCD14 in serum may contribute to the host response to LPS in periodontitis. Furthermore, we showed in vitro that addition of LPS enhanced the release of sCD14 by monoblastic U937 cells treated with 1alpha,25-dihydroxyvitamin D3. Thus, increased sCD14 levels in periodontitis patients may be due to chronic exposure to LPS.
Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury (2002)

Mortality related to adult respiratory distress syndrome (ARDS) ranges from 35% to 65%.Lung-protective ventilator strategies can reduce mortality during ARDS.The protective strategies limit tidal volumes and peak pressures while maximizing positive end-expiratory pressure.The efficacy of this approach is due to a reduction of shear-stress of the lung and release of inflammatory mediators.Ventilator-induced lung injury (VILI) is characterized by inflammation.The specific mechanism(s) that recruit leukocytes during VILI have not been elucidated.Because the murine CXC chemokines KC/CXCL1 and MIP-2/CXCL2/3, via CXCR2, are potent neutrophil chemoattractants, we investigated their role in a murine model of VILI.We compared two ventilator strategies in C57BL/6 mice: high peak pressure and high stretch (high peak pressure/stretch) versus low peak pressure/stretch for 6 hours.Lung injury and neutrophil sequestration from the high-peak pressure/stretch group were greater than those from the low-peak pressure/stretch group.In addition, lung expression of KC/CXCL1 and MIP-2/CXCL2/3 paralleled lung injury and neutrophil sequestration.Moreover, in vivo inhibition of CXCR2/CXC chemokine ligand interactions led to a marked reduction in neutrophil sequestration and lung injury.These findings were confirmed using CXCR2 -/-mice.Together these experiments support the notion that increased expression of KC/CXCL1 and MIP-2/CXCL2/3 and their interaction with CXCR2 are important in the pathogeneses of VILI.
DICOM media interchange standards for cardiology: initial interoperability demonstration. (1995)

The first multi-vendor demonstration of digital exchange of cardiac image data was held in conjunction with the annual scientific sessions of the American College of Cardiology (ACC) in March, 1995. This was the culmination of several years of effort by the ACC to help extend the DICOM standard to be suitable for cardiac images exchanged on removeable media. The software was designed to help system implementors with little or no DICOM experience quickly acquire this technology. File content can be specified and manipulated in human-readable form, and converted as needed to its binary equivalent. Images were selected from those submitted from a variety of sources, and a recordable CD (CD-R) created with 30 echocardiograms and 30 angiograms). A prototype display program was created that reads the DICOM directory ("DICOMDIR"), allows user interaction, and decompresses the image files. This paper describes the ACC's interoperability demonstration with 29 vendors, the CD-R of images that was used, and the software used by the participants.
Low temperature plasma-enhanced ALD enables cost-effective spacer defined double patterning (SDDP) (2009)

The inherent advantages of the Plasma-Enhanced Atomic Layer Deposition (PEALD) technology&#151;excellent conformality and within wafer uniformity, no loading effect&#151;overcome the limitations in this domain of the standard PECVD technique for spacer deposition. The low temperature process capability of PEALD silicon oxide enables direct spacer deposition on photoresist, thus suppressing the need of a patterned template hardmask to design the spacers. By decreasing the number of deposition and patterning steps, this so-called Direct Spacer Defined Double Patterning (DSDDP) integration reduces cost and complexity of the conventional SDDP approach. A successful integration is reported for 32 nm half-pitch polysilicon lines. The performances are promising, especially from the lines, which result from the PEALD spacers: Critical Dimension Uniformity (CDU) of 1.3 nm and Line Width Roughness (LWR) of 2.0 nm.
Identification by a Differential Proteomic Approach of Heat Shock Protein 27 as a Potential Marker of Atherosclerosis (2004)

HSP27 secretion is decreased in complicated atherosclerotic plaques, and sHSP27 plasma levels are decreased in atherosclerotic patients compared with healthy subjects. Plasma sHSP27 levels could be a potential index of atherosclerosis, although further validation is needed in large patient cohorts.
Sexual Offenders, Violence and Testosterone: A Clinical Study (1984)

Sexual assault has increased steadily over the last decade. Attempts at a more accurate evaluation of the violent sexual offender have included studies looking for correlation between plasma testosterone and high levels of sexual violence. The present study failed to replicate these findings, however, it confirmed the known association between violence and alcoholism. The significant association between a psychiatric diagnosis of depressive neurosis and low plasma testosterone levels was an associated finding.
Detection of respiratory syncytial virus by RNA‐polymerase chain reaction and differentiation of subgroups with oligonucleotide probes (1994)

The polymerase chain reaction (RNA-PCR) was used for specific detection of respiratory syncytial virus (RSV) genomes in clinical specimens. A set of primers was selected from conserved regions of the 1B and N genes for detection of both subgroups. The primers were found to be RSV specific, all RSV strains generated a 218 bp product, and no RSV specific amplified product was obtained when nucleic acids from a variety of micro-organisms from the respiratory tract were subjected to the RNA-PCR. We took advantage of the sequence heterogeneity of the amplified products to discriminate between the A and B strains by hybridisation with subgroup specific oligonucleotide probes. This additional hybridisation assay increased the sensitivity of the RNA-PCR tenfold. The RNA-PCR was tested on clinical specimens from children with symptoms of an infection of the respiratory tract. The results were compared with isolation of RSV in cell culture and direct immunofluorescence. From 93 specimens tested, 31 were found positive by all three techniques. Six additional positive results were detected using RNA-PCR. From these 37 RSV positive specimens 33 (92%), including all 6 additional positives, were subgroup A and only 4 were subgroup B strains. Thus, the RNA-PCR is a specific and sensitive technique for the detection and subgroup classification of RSV genomes.
4: NG2-expressing cells as oligodendrocyte progenitors in the normal and demyelinated adult CNS (2004)

Glial progenitor cells identified by expression of the NG2 chondroitin sulphate proteoglycan comprise an abundant cell population in both white and grey matter of the mature rodent CNS, 3–10% of the total cell number. They coexpress the PDGF alpha receptor and O4, both markers for the oligodendrocyte lineage, but fail to express proteins characteristic of other glial cell types. The abundance and widespread distribution of these cells has led to the suggestion that they do not only function as oligodendrocyte progenitor cells, although evidence for heterogeneity in the NG2 expressing population and for other functional roles is still scant in the adult CNS. BrdU incorporation studies indicate that they account for at least 70% of cycling cells in the normal CNS. We have investigated the turnover and fate of NG2-expressing cells in the mature uninjured rat CNS to assess their homogeneity. Results suggest that the dividing NG2+ cell population may be heterogeneous, undergoing both symmetric and asymmetric cell division. Examining paired BrdU+ cells over a 10-day period, we found that pairings consisting of one NG2+ cell and one NG2– cell consistently accounted for 20–30% of all paired cells, one of the daughter cells losing expression of NG2 after approximately 3–5 days. Pairs of BrdU+ cells that remained both NG2+ after 5–10 days accounted for 50–65%, suggesting the presence of two distinct populations. Asymmetric pairs were found in all CNS regions, both white and grey matter. BrdU+ oligodendrocytes expressing the myelin protein CNPase appeared 5–7 days after pulse labelling. Although individual BrdU incorporating cells cannot be traced through the oligodendrocyte lineage, small numbers of NG2+CNP+ cells are always seen in the normal mature CNS. The number of NG2+ cells increases 3–10-fold following demyelination in the rat CNS induced via various routes and then returns to control levels following remyelination. NG2+CNP+ immature oligodendrocytes are seen during the early stages of remyelination. It seems likely that NG2+ cells perform many functions in the resting adult CNS. However, the one function for which there is good evidence is their role as oligodendrocyte progenitors.
Antioxidant capacity of human milk and its association with vitamins A and E and fatty acid composition (2009)

This study shows that alpha-tocopherol is an important contributor to the oxidative stability of human milk. Moreover, there was no evidence obtained to show that women who have high levels of milk polyunsaturated fatty acids are predisposed to lower milk antioxidant capacity.
Signal sequences specify the targeting route to the endoplasmic reticulum membrane. (1996)

In the yeast Saccharomyces cerevisiae, only a subset of preproteins that are translocated across the ER membrane require the function of the signal recognition particle (SRP), suggesting that an alternative, SRP-independent pathway must exist (Hann, B.C., and P. Walter. 1991. Cell. 67:131-144). We have established that the two targeting pathways function in parallel. Mutant alleles of SEC62 and SEC63 were isolated that specifically impaired the translocation of SRP-independent preproteins in vivo and in vitro, whereas SRP-dependent preproteins were unaffected. Based on this analysis, preproteins fall into three distinct classes: SRP dependent, SRP independent, and those that can use both pathways. Pathway specificity is conferred by the hydrophobic core of signal sequences. Our studies show a previously unrecognized diversity in ER-directed signal sequences, that carry structural information that serves to identify the route taken.
Catalytic behavior of noble metal/reducible oxide materials for low-temperature carbon monoxide oxidation. 1. Comparison of catalyst performance (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic behavior of noble metal/reducible oxide materials for low-temperature carbon monoxide oxidation. 1. Comparison of catalyst performanceSteven D. Gardner, Gar B. Hoflund, David R. Schryer, Jacqueline Schryer, Billy T. Upchurch, and Erik J. KielinCite this: Langmuir 1991, 7, 10, 2135–2139Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/la00058a027https://doi.org/10.1021/la00058a027research-articleACS PublicationsRequest reuse permissionsArticle Views730Altmetric-Citations135LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Measuring susceptibility in maize varieties in free and no choice tests against Sitophilus oryzae (L.) and Rhyzopertha dominica (F.) (2006)

Among six maize varieties evaluated against Sitophilus oryzae and Rhyzopertha dominica, Madhuri (sweet corn) and Shaktiman-1 (Quality protein maize) remained most and least susceptible, respectively, when released in equal numbers in interspecific competition in no choice test. S. oryzae was found to be dominating species over R. dominica in competition in all six maize varieties tested. S. oryzae showed significant correlation with grain weight loss and R. dominica with flour produced. In free choice test, Shaktiman-1 attracted nearly 60% S. oryzae but its population build-up and % weight loss was not significantly different from Madhuri which attracted only 15% of the released insects. In no choice test, variety Basi local was intermediate in susceptibility but was found least susceptible to R. dominica in free choice test.
Reduction of Plasma Lipids, Lipoproteins, and Apoproteins by Dietary Fish Oils in Patients with Hypertriglyceridemia (1985)

Dietary fish oils, which are rich in omega-3 fatty acids, have been reported to reduce plasma lipid levels in normolipidemic subjects. We examined the effects of fish oil in 20 hypertriglyceridemic patients: 10 with Type IIb hyperlipidemia and 10 with Type V. These patients were put on three diets differing primarily in fatty acid composition and fat content. The control diet contained a fatty acid mixture typical of a low-fat therapeutic diet (ratio of polyunsaturated to saturated fat, 1.4), the fish-oil diet contained omega-3 fatty acids, and the vegetable-oil diet was rich in the omega-6 fatty acid, linoleic acid. Each diet was followed for four weeks. In the Type IIb group, the fish-oil diet led to decreases in both plasma cholesterol (-27 per cent) and triglyceride (-64 per cent), as compared with the control diet. Very-low-density lipoproteins (VLDLs) were also reduced markedly. The vegetable-oil diet had much less effect. With fish oil, the Type V group had marked decreases in total cholesterol and triglyceride levels (-45 and -79 per cent, respectively). VLDL levels were dramatically lowered, as were apoprotein E levels. The vegetable-oil diet (unlike the fish-oil diet) produced a rapid and significant rise in plasma triglyceride levels. We conclude that fish oils and fish may be useful components of diets for the treatment of hypertriglyceridemia.
Synthesis of the N-linked oligosaccharides of glycoproteins. Assembly of the lipid-linked precursor oligosaccharide and its relation to protein synthesis in vivo. (1980)

The asparagine-linked oligosaccharides of chick embryo fibroblast glycoproteins were previously shown to derive from a common lipid-linked precursor, Glc3Man9GlcNAc2. The formation of this precursor oligosaccharide was examined in intact chick embryo fibroblasts, NIL-8 cells, and Chinese hamster ovary cells. The labeling kinetics and compositions of the lipid-linked oligosaccharides were examined, and the results indicate that lipid-linked Man5GlcNAc2 is rapidly assembled (< 1.5 min) and then extended (< 2.5 min) to Glc3Man9GlcNAc2 via the intermediate Man8GlcNAc2. Chain elongation from Man5GlcNAc2- to Man8GlcNAc2-lipid probably occurs by addition of single mannose residues. The pool of lipid-linked Glc3Man9GlcNAc2 turns over with a half-time of 3.5 to 6 min; since there is little if any degradation (the mannose residues do not turn over), this reflects the rate at which completed chains are transferred to acceptor proteins. The same intermediates and similar kinetics were observed in all three cell types. Oligosaccharide-lipid assembly was also examined in cells in which protein synthesis was decreased (using actinomycin D to depress levels of mRNA) or abolished (using cycloheximide). The results indicate that the rate of oligosaccharide-lipid synthesis is proportional to the rate of protein synthesis. The regulated step is prior to the Man5GlcNAc2 stage, and we suggest that the most likely control mechanism is limitation of available oligosaccharide carrier lipid.
Herpes Simplex Virus Requires Poly(ADP-Ribose) Polymerase Activity for Efficient Replication and Induces Extracellular Signal-Related Kinase-Dependent Phosphorylation and ICP0-Dependent Nuclear Localization of Tankyrase 1 (2011)

Tankyrase 1 is a poly(ADP-ribose) polymerase (PARP) which localizes to multiple subcellular sites, including telomeres and mitotic centrosomes. Poly(ADP-ribosyl)ation of the nuclear mitotic apparatus (NuMA) protein by tankyrase 1 during mitosis is essential for sister telomere resolution and mitotic spindle pole formation. In interphase cells, tankyrase 1 resides in the cytoplasm, and its role therein is not well understood. In this study, we found that herpes simplex virus (HSV) infection induced extensive modification of tankyrase 1 but not tankyrase 2. This modification was dependent on extracellular signal-regulated kinase (ERK) activity triggered by HSV infection. Following HSV-1 infection, tankyrase 1 was recruited to the nucleus. In the early phase of infection, tankyrase 1 colocalized with ICP0 and thereafter localized within the HSV replication compartment, which was blocked in cells infected with the HSV-1 ICP0-null mutant R7910. In the absence of infection, ICP0 interacted with tankyrase 1 and efficiently promoted its nuclear localization. HSV did not replicate efficiently in cells depleted of both tankyrases 1 and 2. Moreover, XAV939, an inhibitor of tankyrase PARP activity, decreased viral titers to 2 to 5% of control values. We concluded that HSV targets tankyrase 1 in an ICP0- and ERK-dependent manner to facilitate its replication.
Major Subsets of Human Dendritic Cells Are Efficiently Transduced by Self-Complementary Adeno-Associated Virus Vectors 1 and 2 (2007)

Dendritic cells (DC) are antigen-presenting cells pivotal for inducing immunity or tolerance. Gene transfer into DC is an important strategy for developing immunotherapeutic approaches against infectious pathogens and cancers. One of the vectors previously described for the transduction of human monocytes or DC is the recombinant adeno-associated virus (rAAV), with a genome conventionally packaged as a single-stranded (ss) molecule. Nevertheless, its use is limited by the poor and variable transduction efficiency of DC. In this study, AAV type 1 (AAV1) and AAV2 vectors, which expressed the enhanced green fluorescent protein and were packaged as ss or self-complementary (sc) duplex strands, were used to transduce different DC subsets generated ex vivo and the immunophenotypes, states of differentiation, and functions of the subsets were carefully examined. We show here for the first time that a single exposure of monocytes (M(o)) or CD34(+) progenitors (CD34) to sc rAAV1 or sc rAAV2 leads to high transduction levels (5 to 59%) of differentiated M(o)-DC, M(o)-Langerhans cells (LC), CD34-LC, or CD34-plasmacytoid DC (pDC), with no impact on their phenotypes and functional maturation of these cells, compared to those of exposure to ss rAAV. Moreover, we show that all these DC subpopulations can also be efficiently transduced after commitment to their differentiation pathways. Furthermore, these DC subsets transduced with sc rAAV1 expressing a tumor antigen were potent activators of a CD8(+)-T-cell clone. Altogether, these results show the high potential of sc AAV1 and sc AAV2 vectors to transduce ex vivo conventional DC, LC, or pDC or to directly target them in vivo for the design of new DC-based immunotherapies.
Cellulomonas sp. KL-6 로 부터의 cellulase 의 생산조절 (1995)

This study was about the reaction conditions for the production of cellulase that Cellulomonas sp. KL-6 secrets and the effect of added inducer for improving enzymatic degradation of cellulase substrate. The optimal pH of cellulase were8.0 for CMCase, s-glucosidase and 7.0 for FP_(ase). Cellulase appeared to have settled pH in a wide range mostly. The optimum conditions of enzyme reaction were 40t, 40min with 10% of CMC substrate for CM_(Case), 40`C, 50min with filter paper strip substrate for FP_(ase) and 30`C, 40min with 0.005M pNPG substrate for s-glucosidase. When this strain was reacted under the above conditions, production of CMC_(ase), FP_(ase_) and s -glucosidase were accelerated, these results were showed to increased enzyme production as about 5-165% than those produced in basal conditions. The production of CMC_(ase) and FP_(ase) in CMC medium, the supplements of 0.5% of glucose and cellobiose had no effect but 1.0% of addition increased. For s-glucosidase, the addition of cellobiose heighten the production of CMC_(ase) and FP_(ase), but wasn`t effective for s-glucosidase.
A Targeting Microbubble for Ultrasound Molecular Imaging (2015)

Targeting microbubbles for ultrasound molecular imaging, based on maleimide-thiol conjugation chemistry and the generic composition described, may possess properties (i)-(iii) desired for clinical applications.
Trophic effects of skeletal muscle extracts on ventral spinal cord neurons in vitro: separation of a protein with morphologic activity from proteins with cholinergic activity. (1985)

Protein factors derived from skeletal muscle separately promote neurite elongation and acetylcholine synthesis in cultured rat ventral spinal neurons. Morphologic factor activity (neurite-inducing activity) is specifically found in rat skeletal muscle and cord neuron extracts, decreases with the postnatal age of the rats from which muscle extract is prepared, and increases in rat hindlimb muscle after 5 d of denervation. Cholinergic factor activity (acetylcholine synthesis-stimulating activity) is found in extracts of rat cerebral cortex and cardiac muscle in addition to spinal cord and skeletal muscle, increases with animal age, and decreases following 5 d of denervation. Biochemically, the factors responsible for these activities differ in their lability to denaturing conditions, apparent molecular weights, isoelectric points, and lectin-binding specificities. Under reducing conditions, morphologic activity is isolated in a single acidic glycoprotein with an Mr of 35,000, while acetylcholine synthesis-stimulating activity is found in multiple species of different molecular weights. Thus, acetylcholine synthesis-promoting activities and neurite growth-promoting activity appear to reside in different molecules. Significant purification of several of these factors has been achieved.