gebhart/patrepeval huggingface dataset:
Evaluation of novel biomarkers for the diagnosis of acute destabilised heart failure in patients with shortness of breath (2009)

The data showed that BNP and MR-proANP were the only independent diagnostic markers of HF. Both markers provided similar diagnostic information and were clinically useful as an aid in the diagnosis of acute destabilised HF in an emergency setting.
Synaptic dynamics control the timing of neuronal excitation in the activated neocortical microcircuit (2004)

It is well established that sensory stimulation results in the activity of multiple functional columns in the neocortex. The manner in which neurones within each column are active in relation to each other is, however, not known. Multiple whole-cell recordings in activated neocortical slices from rat revealed diverse correlation profiles of excitatory synaptic input to different types of neurones. The specific correlation profile between any two neurones could be predicted by the settings of synaptic depression and facilitation at the input synapses. Simulations further showed that patterned activity is essential for synaptic dynamics to impose the temporal dispersion of excitatory input. We propose that synaptic dynamics choreograph neuronal activity within the neocortical microcircuit in a context-dependent manner.
A fast direct Fourier-based algorithm for subpixel registration of images (2001)

This paper presents a new direct Fourier-based algorithm for performing image-to-image registration to subpixel accuracy, where the image differences are restricted to translations and uniform changes of illumination. The algorithm detects the Fourier components that have become unreliable estimators of shift due to aliasing, and removes them from the shift-estimate computation. In the presence of aliasing, the average precision of the registration is a few hundredths of a pixel. Experimental data presented here show that the new algorithm yields superior registration precision in the presence of aliasing when compared to several earlier methods and has comparable precision to the iterative method of P. Thevenaz et al. (1998).
Studies in the (+)-morphinan series. 5. Synthesis and biological properties of (+)-naloxone (1978)

(+)-Naloxone was prepared in 26% overall yield in eight steps from (+)-7-bromodihydrocodeinone dimethyl ketal by a synthesis which excluded enantiomeric contamination. (+)-Naloxone was examined in three assay systems and found to have no more than 1/1000(-1)/10 000th the activity of (-)-naloxone; it can, thus, serve to test the stereospecificity of the biochemical and pharmacological actions of (-)-naloxone.
Protein encapsulation in liposomes: efficiency depends on interactions between protein and phospholipid bilayer. (2002)

We propose here an optimized procedure to encapsulate fragile enzymes into liposomes. Optimal encapsulation is achieved by induction of a specific interaction between the enzyme and the lipid surface.
Polyphonic Audio Matching for Score Following and Intelligent Audio Editors (2018)

Getting computers to understand and process audio recordings in terms of their musical content is a difficult challenge. We describe a method in which general, polyphonic audio recordings of music can be aligned to symbolic score information in standard MIDI files. Because of the difficulties of polyphonic transcription, we perform matching directly on acoustic features that we extract from MIDI and audio. Polyphonic audio matching can be used for polyphonic score following, building intelligent editors that understand the content of recorded audio, and the analysis of expressive performance.
On Coding for Delay—Network Coding for Time-Division Duplexing (2012)

In networks with large latency, feedback about received packets may lag considerably the transmission of the original packets, limiting the feedback's usefulness. Moreover, time duplex constraints may entail that receiving feedback may be costly. In this work, we consider tailoring feedback and coding jointly in such settings to reduce the expected delay for successful in order reception of packets. We find that, in certain applications, judicious choices provide results that are close to those that would be obtained with a full-duplex system. We study two cases of data transmission: one-to-all broadcast and all-to-all broadcast. We also analyze important practical considerations weighing the trade off between performance and complexity in applications that rely on random linear network coding. Finally, we study the problem of transmission of information under the large latency and time duplexing constraints in the presence of random packet arrivals. In particular, we analyze the problem of using a batch by batch approach and an online network coding approach with Poisson arrivals. We present numerical results to illustrate the performance under a variety of scenarios and show the benefits of the proposed schemes as compared to typical ARQ and scheduling schemes.
Novel Polyethylenimine-Modified Mesoporous Molecular Sieve of MCM-41 Type as High-Capacity Adsorbent for CO2 Capture (2002)

The objective of the work presented here is to develop a nanoporous solid adsorbent which can serve as a “molecular basket” for CO2 in the condensed form. Polyethylenimine (PEI)-modified mesoporous molecular sieve of MCM-41 type (MCM-41-PEI) has been prepared and tested as a CO2 adsorbent. The physical properties of the adsorbents were characterized by X-ray powder diffraction (XRD), N2 adsorption/desorption, and thermogravimetric analysis (TGA). The characterizations indicated that the structure of the MCM-41 was preserved after loading the PEI, and the PEI was uniformly dispersed into the channels of the molecular sieve. The CO2 adsorption/desorption performance was tested in a flow system using a microbalance to track the weight change. The mesoporous molecular sieve had a synergetic effect on the adsorption of CO2 by PEI. A CO2 adsorption capacity as high as 215 mg-CO2/g-PEI was obtained with MCM-41-PEI-50 at 75 °C, which is 24 times higher than that of the MCM-41 and is even 2 times that of the pure PEI. With an increase in the CO2 concentration in the CO2/N2 gas mixture, the CO2 adsorption capacity increased. The cyclic adsorption/desorption operation indicated that the performance of the adsorbent was stable.
MHC affinity, peptide liberation, T cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL (1997)

MHC class I-restricted T cell responses to viral proteins focus on a limited set of peptides. To better understand this phenomenon, we examined all of the 26 nonameric peptides encoded by the influenza virus A/Puerto Rico/8/34 (PR8) conforming to the canonical Kd binding motif. Ten peptides bound strongly to Kd as assessed by a cell surface stabilization assay. Five of these 10 induced in vitro secondary CD8+ T cell responses from splenocytes derived from PR8-immunized mice. The strongest responses were induced by the two previously defined antigenic peptides, which ranked only second and fifth in relative binding affinity. To examine the limiting factors in the immunogenicity of Kd-binding peptides, we produced recombinant vaccinia viruses (rVVs) expressing cytosolic or endoplasmic reticulum (ER)-targeted peptides. rVVs expressing ER-targeted versions of the 7 peptides with the highest relative affinities for Kd rescued Kd cell surface expression in T2 cells, while those expressing the 3 lowest affinity peptides did not. The immunogenicity of several, but not all, of the highest affinity peptides was greatly enhanced when expressed as VV-encoded cytosolic or ER-targeted peptides as compared with full length proteins. We conclude that limitations in the immunogenicity of class I binding peptides reflects, in order of decreasing importance, peptide liberation by cellular proteases, T cell repertoire, and TAP-mediated peptide transport. We also observed an additional important contributing factor: suppression of T cell responses to nondominant peptides by an immunodominant peptide located in the same protein.
Gain dynamics of a saturated semiconductor laser amplifier with 1.47-μm LD pumping (1996)

The dynamic characteristics of a gain saturated semiconductor laser amplifier with 1.47-μm pump light are described. In addition to improving the saturation output power, the pump light injection shortens the gain response time. Bit-error-rate measurements show that signal degradation, induced for a high-bit-rate signal amplified under the gain saturated condition, becomes less with the pump light injection.
Derivation of Two New Human Embryonic Stem Cell Lines from Nonviable Human Embryos (2011)

We report the derivation and characterization of two new human embryonic stem cells (hESC) lines (CU1 and CU2) from embryos with an irreversible loss of integrated organismic function. In addition, we analyzed retrospective data of morphological progression from embryonic day (ED) 5 to ED6 for 2480 embryos not suitable for clinical use to assess grading criteria indicative of loss of viability on ED5. Our analysis indicated that a large proportion of in vitro fertilization (IVF) embryos not suitable for clinical use could be used for hESC derivation. Based on these combined findings, we propose that criteria commonly used in IVF clinics to determine optimal embryos for uterine transfer can be employed to predict the potential for hESC derivation from poor quality embryos without the destruction of vital human embryos.
Merging virtual objects with the real world (1992)

article Free Access Share on Merging virtual objects with the real world: seeing ultrasound imagery within the patient Authors: Michael Bajura Department of Computer Science, University of North Carolina, Chapel Hill, NC Department of Computer Science, University of North Carolina, Chapel Hill, NCView Profile , Henry Fuchs Department of Computer Science, University of North Carolina, Chapel Hill, NC Department of Computer Science, University of North Carolina, Chapel Hill, NCView Profile , Ryutarou Ohbuchi Department of Computer Science, University of North Carolina, Chapel Hill, NC Department of Computer Science, University of North Carolina, Chapel Hill, NCView Profile Authors Info & Claims ACM SIGGRAPH Computer GraphicsVolume 26Issue 2July 1992 pp 203–210https://doi.org/10.1145/142920.134061Online:01 July 1992Publication History 374citation3,190DownloadsMetricsTotal Citations374Total Downloads3,190Last 12 Months169Last 6 weeks38 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Expression System for High Levels of GAG Lyase Gene Expression and Study of the hepA Upstream Region in Flavobacterium heparinum (2002)

A system for high-level expression of heparinase I, heparinase II, heparinase III, chondroitinase AC, and chondroitinase B in Flavobacterium heparinum is described. hepA, along with its regulatory region, as well as hepB, hepC, cslA, and cslB, cloned downstream of the hepA regulatory region, was integrated in the chromosome to yield stable transconjugant strains. The level of heparinase I and II expression from the transconjugant strains was approximately fivefold higher, while heparinase III expression was 10-fold higher than in wild-type F. heparinum grown in heparin-only medium. The chondroitinase AC and B transconjugant strains, grown in heparin-only medium, yielded 20- and 13-fold increases, respectively, in chondroitinase AC and B expression, compared to wild-type F. heparinum grown in chondroitin sulfate A-only medium. The hepA upstream region was also studied using cslA as a reporter gene, and the transcriptional start site was determined to be 26 bp upstream of the start codon in the chondroitinase AC transconjugant strain. The transcriptional start sites were determined for hepA in both the wild-type F. heparinum and heparinase I transconjugant strains and were shown to be the same as in the chondroitinase AC transconjugant strain. The five GAG lyases were purified from these transconjugant strains and shown to be identical to their wild-type counterparts.
Predictive value of RIFLE classification on prognosis of critically ill patients with acute kidney injury treated with continuous renal replacement therapy. (2009)

The RIFLE classification may be used to predict 90-day survival after starting CRRT and the malignant kidney outcome of 90-day survivors in the critically ill patients with AKI treated with CRRT. Starting CRRT prior to RIFLE-F stage may be the optimal timing. Prospective, multi-center, randomized controlled trials are needed to confirm its predictive value in these patients.
Growth factor receptors as molecular targets for cancer diagnosis and therapy. (1997)

Growth factor receptors are of great interest as molecular targets for the diagnosis and treatment of cancer. Growth factor receptors are frequently over expressed on malignant cell populations since many cellular oncogenes encode either growth factors or their receptors. The wild-type epidermal growth factor receptor has a molecular weight of 170 kD and is over expressed on gliomas, bladder tumors, squamous cells carcinomas and breast carcinomas. Another growth factor oncogene, c-erbB-2, encodes a 185-kD glycoprotein found on the surface of gliomas, breast and ovarian cancers as well as other carcinomas of epithelial origin. In addition to causing over expression, oncogenic transformation also can result in genomic re-arrangements. An important example from the perspective of targeting is EGFRvIII, a deletion mutant which lacks amino acids 6-273 in the extracellular domain of the epidermal growth factor receptor. The EGFRvIII molecule (145 kD) may be of great value for targeting because it appears to be tumor-specific. Antibodies have been developed with specific reactivity with these growth factor receptors. Since these antibodies are internalized into the cell after receptor binding, it is necessary to use radiolabeling methods which residualize the radioactivity in the tumor cell after intracellular catabolism. To investigate this problem, we have evaluated the effect of radioiodination method on the in vitro and in vivo properties of an anti-EGFRvIII antibody. Methods studied were Iodogen, tyramine-cellobiose, and N-succinimidyl 5-iodo-3-pyridine-carboxylate with the last offering optimal localization in a human xenograft model.
Automatic correction to misspelled names (1987)

Using an information theoretic likeness measure defined as an inner product on a data space created from a table of valid names, this 4GL procedure searches the database space for the nearest correctly spelled name.
Practitioner research and literacy studies: Toward more dialogic methodologies (2012)

This article examines the potential of practitioner research to contribute to understandings of critical and transformative literacy theories. Drawing upon the work of intellectual historian Dominick LaCapra (2004), we investigate how practitioner research can reconcile theories proliferated from universities with those generated by practitioners, who e literacy from their work with students in classrooms and communities. Following a review of scholarship by literacy teachers, we examine examples of practitioner inquiry conducted in a graduate literacy course to discuss the following: What happens when school- and community-based practitioners are in dialogue with academic literature in the field of literacy? How can practitioner research encourage educators to develop their own working theories of literacy practice? And what can the broader field of literacy learn from activist practitioner researchers? In conclusion, we suggest several interconnected ways that practitioner research methodologies can inform more dialectical understandings of literacy practice and theory.
HIV gp41 C-terminal Heptad Repeat Contains Multifunctional Domains (2007)

T20 (Fuzeon), a novel anti-human immunodeficiency virus (HIV) drug, is a peptide derived from HIV-1 gp41 C-terminal heptad repeat (CHR). Its mechanism of action has not yet been defined. We applied Pepscan strategy to determine the relationship between functional domains and mechanisms of action of five 36-mer overlapping peptides with a shift of five amino acids (aa): CHR-1 (aa 623-658), C36 (aa 628-663), CHR-3 (aa 633-668), T20 (aa 638-673), and CHR-5 (aa 643-678). C36 is a peptide with addition of two aa to the N terminus of C34. Peptides CHR-1 and C36 contain N-terminal heptad repeat (NHR)- and pocket-binding domains. They inhibited HIV-1 fusion by interacting with gp41 NHR, forming stable six-helix bundles and blocking gp41 core formation. Peptide T20 containing partial NHR- and lipid-binding domains, but lacking pocket-binding domain, blocked viral fusion by binding its N- and C-terminal sequences with gp41 NHR and cell membrane, respectively. Peptide CHR-3, which is located in the middle between C36 and T20, overlaps >86% of the sequences of these two peptides, and lacks pocket- and lipid-binding domains, exhibited marginal anti-HIV-1 activity. These results suggest that T20 and C36 contain different functional domains, through which they inhibit HIV-1 entry with distinct mechanisms of action. The multiple functional domains in gp41 CHR and their binding partners may serve as targets for rational design of new anti-HIV-1 drugs and vaccines.
Human low-dosage parenteral methotrexate therapy. A controlled toxicity study. (1966)

Methotrexate was administered intramuscularly to ten patients with severe psoriasis and one patient with a generalized erythroderma. All patients were observed carefully for toxicity by the use of a number of laboratory procedures. Clinical improvement was compared with a control group receiving placebo injections and standard dermatologic topical therapy. The results indicate that methotrexate administered intramuscularly is a therapeutically beneficial drug; however, it is a potentially toxic drug, unless precautions are observed.
Prostate Antigen: A Marker for Human Prostate Epithelial Cells<xref ref-type="fn" rid="fn2">2</xref> (1981)

Specificity of a previously reported prostate antigen (PA) was assessed by several immunologic procedures. This antigen, restricted in distribution to the prostate gland, was detected within ductal epithelial cells. Continuous established cell lines LNCaP and PC-3 of malignant prostate origin retained the expression of PA. Tumor cells released the antigen in vitro into the culture fluid and also in vivo into the circulation of nude mice preinoculated with LNCaP cells. Prostate cells in culture also specifically accreted immunoglobulin fragments of PA antiserum.
Outflow resistance of enucleated human eyes at two different perfusion pressures and different extents of trabeculotomy (1989)

Aqueous outflow resistance of enucleated human eyes was measured at 7 and 25 mm Hg before and after partial and complete (12 clock hours) internal trabeculotomy. Following complete trabeculotomy, 71% of the resistance was eliminated at 25 mm Hg while only 49% was eliminated at 7 mm Hg. In contrast to published findings in eyes with intact trabecular meshwork where the resistance increased with increasing IOP (1), following complete trabeculotomy, the resistance decreased 2% per mm Hg with increasing IOP. Experiments with trabeculotomy limited to part of the circumference showed that a one hour trabeculotomy produced 41% (25 mm Hg) to 60% (7 mm Hg) of the effect of a twelve hour trabeculotomy. The results indicate that a surprisingly high fraction of aqueous outflow resistance resides in the distal aspects of the outflow system at normal IOP, and that this distal resistance drops as IOP is increased.
Activation of Tumor-Promoting Type 2 Macrophages by EGFR-Targeting Antibody Cetuximab (2011)

These results suggest that tumor-promoting M2 macrophages are activated by the therapeutic mAb cetuximab in the local tumor microenvironment and argue that this immune mechanism should be taken into account for the application of therapeutic antibodies.
Crosslinking of hydroxamic acid copolymers through iron chelation (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrosslinking of hydroxamic acid copolymers through iron chelationJ. W. Rosthauser and A. WinstonCite this: Macromolecules 1981, 14, 3, 538–543Publication Date (Print):May 1, 1981Publication History Published online1 May 2002Published inissue 1 May 1981https://pubs.acs.org/doi/10.1021/ma50004a015https://doi.org/10.1021/ma50004a015research-articleACS PublicationsRequest reuse permissionsArticle Views220Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention (2011)

Phospholipases represent one of the earliest enzyme activities to be identified and studied, and the phospholipase A2 superfamily traces its roots to the identification of lytic actions of snake venom at the end of the 19th century. Both electrostatic and hydrophobic interactions contribute to the interfacial binding of sPLA2 to anionic phospholipid membranes. The interaction between basic residues on the binding surface with anionic vesicles plays an important role in interfacial binding. The major functions will be summarized below and include the ability to kill Gram-positive and Gram-negative bacteria, thereby affecting host defense against bacterial infections. sPLA2 may be involved in the pathogensis of inflammatory bowel disease including Crohn's disease and ulcerative colitis. GIIA sPLA2 protein and mRNA were detected in Paneth cells of the small intestinal mucosa in the intestine in Crohn's disease patients.
Exploring trust building processes in the face of conflict (2009)

This paper presents an investigation of the processes by which trust can be built in the face of interpersonal workplace conflict. Using grounded theory approach, we analysed the qualitative data collected from 45 team leaders and members in two organisations employing semi-structure interviews. Data analysis revealed the complex nature of the relationship between conflict and trust. While employees have various perceptions of values, shared values (team and personal values) were revealed to be critical in trust building when there is conflict. Additionally, participants agreed that a climate of honest and open communication as pivotal for building trust in the face of conflict. Implications for theory and practice are discussed.