gebhart/patrepeval huggingface dataset:
Microwave applicator for transurethral hyperthermia of benign prostatic hyperplasia (1989)

An applicator for heating the prostate gland using a transurethral approach is described. This technique uses three microwave antennas and a thermometry sensor attached to the outer surface of a balloon (Foley) type urological catheter. Each microwave antenna also includes a built-in thermistor to control temperature and balance power. The balloon catheter assures rapid and reproducible localization of the antennas in the prostatic urethra. The two-dimensional SAR and steady-state temperature distributions surrounding the applicator in tissue equivalent phantom are reported. Longitudinal temperature distributions measured in situ at the applicator-urethral interface and the longitudinal and radial temperature distributions measured in normal canine prostate are presented and discussed. The technique appears to be capable of elevating temperature to greater than 42 degrees C in a cylindrically symmetrical volume up to 5 cm length and 0.5 cm radial penetration surrounding the applicator.
Proteomic Analyses of Pancreatic Cyst Fluids (2009)

Two homologs of amylase, solubilized molecules of 4 mucins, 4 solubilized CEA-related cell adhesion molecules (CEACAMs), and 4 S100 homologs may be candidate biomarkers to facilitate future pancreatic cyst diagnosis and risk-stratification. This approach required less than 40 microL of cyst fluid per sample, offering the possibility to analyze cysts smaller than 1 cm in diameter.
A Cell for In Situ X‐Ray Diffraction Based on Coin Cell Hardware and Bellcore Plastic Electrode Technology (1997)

In situ x‐ray diffraction has been shown to be a powerful tool for the study of the crystallographic changes that occur in a material as intercalation proceeds. Here we report the development of an in situ cell based on coin cell hardware and Bellcore plastic electrode technology. The coin cell hardware makes construction very simple, the cells seal well and cycle just as regular coin cells do. Therefore extended in situ x‐ray studies as a function of cycle number are now possible. We demonstrate the new design with preliminary experiments on and .
<title>Guided-mode grating resonant filters for VCSEL applications</title> (1998)

A brief summary of both VCSEL technology and guided-mode grating resonant filters (GMGRFs) is presented. We then discuss benefits and issues of integrating the two technologies, emphasizing control of wavelength, polarization, and laser cavity modes. We present a GMGRF design suitable for a 980 nm InGaAs VCSEL and show that a significant loss (-4%) in reflectivity results from the slight loss associated with the minimum mirror conductivity required to inject current through the mirror. Experimental data are presented at 850 mm for gratings designed for and fabricated on fused silica substrates and illustrate that GMGRFs are also very sensitive to other forms of loss such as scatter caused by roughness in the grating lines. We suggest a hybrid approach of a GMGRF on a reduced distributed Bragg reflector stack as a means to circumvent the high sensitivity to loss in the GMGRF.
High Incidence of the Cardiac Variant of Fabry Disease Revealed by Newborn Screening in the Taiwan Chinese Population (2009)

We found an unexpected high prevalence of the cardiac variant Fabry mutation IVS4+919G-->A among both newborns (approximately 1 in 1600 males) and patients with idiopathic hypertrophic cardiomyopathy in the Taiwan Chinese population. The early identification of undiagnosed patients allows timely therapeutic intervention providing a better clinical outcome.
Lower body negative pressure to provide load bearing in space. (1991)

Presently, exercise protocols and equipment for spaceflight are unresolved, although recent calculations suggest that all exercise in space to date has lacked sufficient loads to maintain preflight musculoskeletal mass. We hypothesized that lower body negative pressure (LBNP) produces a footward force equal to the product of the pressure differential and body cross-sectional area at the waist seal. Twelve male volunteers weighing 67.6-86.9 kg were sealed at the superior iliac crest in upright and supine LBNP chambers. Neither configuration included a saddle, so that the force due to LBNP was transmitted to the feet of our subjects. Each subject was exposed to 10 mm Hg increments of LBNP up to 70 mm Hg (standing) or to 50-100 mm Hg (supine), depending upon individual tolerance. Static reaction force was measured at each LBNP level for approximately 1-2 min. An additional static force approximately equivalent to 1% Earth body weight was generated against the feet by each mm Hg of LBNP either during upright standing or supine posture. Furthermore, the forces measured during LBNP agreed well with forces calculated from the cross-sectional areas of our subjects' waists. These results indicate that exercise in microgravity against 100 mm Hg LBNP could produce static and inertial forces similar in magnitude to those occurring on Earth. This gravity-independent technique may help maintain the musculoskeletal and cardiovascular systems of crewmembers during prolonged exposure to microgravity.
Continuous reactions. Part II. The kinetics of steady state polymerisation (1947)

K. G. Denbigh, Trans. Faraday Soc., 1947, 43, 648 DOI: 10.1039/TF9474300648
The Importance of Diagnostic Cytogenetics on Outcome in AML: Analysis of 1,612 Patients Entered Into the MRC AML 10 Trial (1998)

Cytogenetics is considered one of the most valuable prognostic determinants in acute myeloid leukemia (AML). However, many studies on which this assertion is based were limited by relatively small sample sizes or varying treatment approach, leading to conflicting data regarding the prognostic implications of specific cytogenetic abnormalities. The Medical Research Council (MRC) AML 10 trial, which included children and adults up to 55 years of age, not only affords the opportunity to determine the independent prognostic significance of pretreatment cytogenetics in the context of large patient groups receiving comparable therapy, but also to address their impact on the outcome of subsequent transplantation procedures performed in first complete remission (CR). On the basis of response to induction treatment, relapse risk, and overall survival, three prognostic groups could be defined by cytogenetic abnormalities detected at presentation in comparison with the outcome of patients with normal karyotype. AML associated with t(8;21), t(15;17) or inv(16) predicted a relatively favorable outcome. Whereas in patients lacking these favorable changes, the presence of a complex karyotype, -5, del(5q), -7, or abnormalities of 3q defined a group with relatively poor prognosis. The remaining group of patients including those with 11q23 abnormalities, +8, +21, +22, del(9q), del(7q) or other miscellaneous structural or numerical defects not encompassed by the favorable or adverse risk groups were found to have an intermediate prognosis. The presence of additional cytogenetic abnormalities did not modify the outcome of patients with favorable cytogenetics. Subgroup analysis demonstrated that the three cytogenetically defined prognostic groups retained their predictive value in the context of secondary as well as de novo AML, within the pediatric age group and furthermore were found to be a key determinant of outcome from autologous or allogeneic bone marrow transplantation (BMT) in first CR. This study highlights the importance of diagnostic cytogenetics as an independent prognostic factor in AML, providing the framework for a stratified treatment approach of this disease, which has been adopted in the current MRC AML 12 trial.
High-quality multimedia conferencing through a long-haul packet network (1993)

Article High-quality multimedia conferencing through a long-haul packet network Share on Author: Chip Elliot View Profile Authors Info & Claims MULTIMEDIA '93: Proceedings of the first ACM international conference on MultimediaSeptember 1993 Pages 91–98https://doi.org/10.1145/166266.166276Online:01 September 1993Publication History 12citation659DownloadsMetricsTotal Citations12Total Downloads659Last 12 Months9Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Molecular therapy for the treatment of hepatocellular carcinoma (2008)

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Conventional cytotoxic chemotherapy has failed to show a substantial benefit for patients with HCC. Recently, a number of new drugs targeting molecular mechanisms involved in liver cell transformation have entered into clinical trials and led to encouraging results. In this review we summarise this data and point to a number of new compounds, which are currently being tested and can potentially broaden our therapeutic arsenal even further.
EGF induces cell cycle arrest of A431 human epidermoid carcinoma cells (1986)

The human carcinoma cell line A431 is unusual in that physiologic concentrations of epidermal growth factor (EGF) inhibit proliferation. In the presence of 5-10 nM EGF proliferation of A431 cells is abruptly and markedly decreased compared to the untreated control cultures, with little loss of cell viability over a 4-day period. This study was initiated to examine how EGF affects the progression of A431 cells through the cell cycle. Flow cytometric analysis of DNA in EGF-treated cells reveals a marked change in the cell cycle distribution. The percentage of cells in late S/G2 increases and early S phase is nearly depleted. Since addition of the mitotic inhibitor vinblastine causes accumulation of cells in mitosis and prevents reentry of cells into G1, it is possible to distinguish between slow progression through G1 and G2 and blocks in those phases. When control cells, not treated with EGF, are exposed to vinblastine, the cells accumulate mitotic figures, as expected, and show progression into S, thus diminishing the number of cells in G1. In contrast, no mitotic figures are found among the EGF-treated cells in the presence or absence of vinblastine, and progression from G1 into S is not observed, as the number of cells in G1 remains constant. These results suggest that there are two EGF-induced blocks in cell cycle transversal; one is in late S and/or G2, blocking entry into mitosis, and the other is in G1, blocking entry into S phase. After 24 hours of EGF treatment, DNA synthesis is reduced to less than 10% compared to untreated controls as measured by the incorporation of [3H]thymidine or BrdU. In contrast, protein synthesis is inhibited by about twofold. Although inhibition of protein synthesis is less extensive, it occurs 6 hours prior to an equivalent inhibition of DNA synthesis. The rapid decrease in protein synthesis may result in the subsequent cell cycle arrest which occurs several hours later.
Developmentally regulated gene expression of thrombomodulin in postimplantation mouse embryos (1996)

Embryonic lethality of thrombomodulin-deficient mice has indicated an essential role for this regulator of blood coagulation in murine development. Here, the embryonic expression pattern of thrombomodulin was defined by surveying beta-galactosidase activity in a mouse strain in which the reporter gene was placed under the regulatory control of the endogenous thrombomodulin promoter via homologous recombination in embryonic stem cells. The murine trophoblast was identified as a previously unrecognized anatomical site where TM expression is conserved between humans and mice and may exert a critical function during postimplantation development. Targeted reporter gene expression in mesodermal precursors of the endothelial cell lineage defined thrombomodulin as an early marker of vascular differentiation. Analysis of the thrombomodulin promoter in differentiating ES cells and in transgenic mice provided evidence for a disparate and cell type-specific gene regulatory control mechanism in the parietal yolk sac. The thrombomodulin promoter as defined in this study will allow the targeting of gene expression to the parietal yolk sac of transgenic mice and the initiation of investigations into the role of parietal endoderm in placental function.
Evolution of Diaschisis in a Focal Stroke Model (2004)

Focal stroke produces ipsilateral diaschisis in connected cortical regions that is clearly distant from subtotal damage and may play a role in poststroke neuroplasticity.
IL-7 is critical for homeostatic proliferation and survival of naïve T cells (2001)

In T cell-deficient conditions, naive T cells undergo spontaneous "homeostatic" proliferation in response to contact with self-MHC/peptide ligands. With the aid of an in vitro system, we show here that homeostatic proliferation is also cytokine-dependent. The cytokines IL-4, IL-7, and IL-15 enhanced homeostatic proliferation of naive T cells in vitro. Of these cytokines, only IL-7 was found to be critical; thus, naive T cells underwent homeostatic proliferation in IL-4(-) and IL-15(-) hosts but proliferated minimally in IL-7(-) hosts. In addition to homeostatic proliferation, the prolonged survival of naive T cells requires IL-7. Thus, naïve T cells disappeared gradually over a 1-month period upon adoptive transfer into IL-7(-) hosts. These findings indicate that naive T cells depend on IL-7 for survival and homeostatic proliferation.
Animation of Mapped Photo Collections for Storytelling (2008)

Our research goal is to facilitate the sharing of stories with digital photographs. Some map websites now collect stories associated with peoples' relationships to places. Users map collections of places and include their intangible emotional associations with each location along with photographs, videos, etc. Though this framework of mapping stories is important, it is not sufficiently expressive to communicate stories in a narrative fashion. For example, when the number of the mapped collections of places is particularly large, it is neither easy for viewers to interpret the map nor is it easy for the creator to express a story as a series of events in the real world. This is because each narrative, in the form of a sequence of textual narratives, a sequence of photographs, a movie, or audio is mapped to just one point. As a result, it is up to the viewer to decide which points on the map must be read, and in what order. The conventional framework is fairly suitable for mapping and expressing fragments or snapshots of a whole story and not for conveying the whole story as a narrative using the entire map as the setting. We therefore propose a new framework, Spatial Slideshow, for mapping personal photo collections and representing them as stories such as route guidances, sightseeing guidances, historical topics, fieldwork records, personal diaries, and so on. It is a fusion of personal photo mapping and photo storytelling. Each story is conveyed through a sequence of mapped photographs, presented as a synchronized animation of a map and an enhanced photo slideshow. The main technical novelty of this paper is a method for creating three-dimensional animations of photographs that induce the visual effect of motion from photo to photo. We believe that the proposed framework may have considerable significance in facilitating the grassroots development of spatial content driven by visual communication concerning real-world locations or events.
Broadband, Miniaturized Stacked-Patch Antennas for L-Band Operation Based on Magneto-Dielectric Substrates (2010)

Design of stacked-patch antennas using magneto-dielectric substrates was investigated. In particular, special types of substrates with identical relative permittivity and permeability were considered. The optimal design parameters were determined using a genetic algorithm. It will be shown that by employing these matched magneto-dielectric substrates, a significant miniaturization of up to 60% can be achieved while providing a large operating bandwidth (20%). Several design examples were considered and their performance was evaluated using a full-wave analysis technique based on the method of moments. The tradeoff between antenna gain and degree of miniaturization for a fixed bandwidth was also investigated. A fabrication methodology for obtaining the required matched magneto-dielectric substrate materials is also proposed.
Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2α kinase (1999)

In eukaryotic cells, protein synthesis is regulated in response to various environmental stresses by phosphorylating the alpha subunit of the eukaryotic initiation factor 2 (eIF2alpha). Three different eIF2alpha kinases have been identified in mammalian cells, the heme-regulated inhibitor (HRI), the interferon-inducible RNA-dependent kinase (PKR) and the endoplasmic reticulum-resident kinase (PERK). A fourth eIF2alpha kinase, termed GCN2, was previously characterized from Saccharomyces cerevisiae, Drosophila melanogaster and Neurospora crassa. Here we describe the cloning of a mouse GCN2 cDNA (MGCN2), which represents the first mammalian GCN2 homolog. MGCN2 has a conserved motif, N-terminal to the kinase subdomain V, and a large insert of 139 amino acids located between subdomains IV and V that are characteristic of the known eIF2alpha kinases. Furthermore, MGCN2 contains a class II aminoacyl-tRNA synthetase domain and a degenerate kinase segment, downstream and upstream of the eIF2alpha kinase domain, respectively, and both are singular features of GCN2 protein kinases. MGCN2 mRNA is expressed as a single message of approximately 5.5 kb in a wide range of different tissues, with the highest levels in the liver and the brain. Specific polyclonal anti-(MGCN2) immunoprecipitated an eIF2alpha kinase activity and recognized a 190 kDa phosphoprotein in Western blots from either mouse liver or MGCN2-transfected 293 cell extracts. Interestingly, serum starvation increased eIF2alpha phosphorylation in MGCN2-transfected human 293T cells. This finding provides evidence that GCN2 is the unique eIF2alpha kinase present in all eukaryotes from yeast to mammals and underscores the role of MGCN2 kinase in translational control and its potential physiological significance.
The EMBL-EBI bioinformatics web and programmatic tools framework (2015)

Since 2009 the EMBL-EBI Job Dispatcher framework has provided free access to a range of mainstream sequence analysis applications. These include sequence similarity search services (https://www.ebi. ac.uk/Tools/sss/) such as BLAST, FASTA and PSI-Search, multiple sequence alignment tools (https: //www.ebi.ac.uk/Tools/msa/) such as Clustal Omega, MAFFT and T-Coffee, and other sequence analysis tools (https://www.ebi.ac.uk/Tools/pfa/) such as InterProScan. Through these services users can search mainstream sequence databases such as ENA, UniProt and Ensembl Genomes, utilising a uniform web interface or systematically through Web Services interfaces (https://www.ebi.ac. uk/Tools/webservices/) using common programming languages, and obtain enriched results with novel visualisations. Integration with EBI Search (https: //www.ebi.ac.uk/ebisearch/) and the dbfetch retrieval service (https://www.ebi.ac.uk/Tools/dbfetch/) further expands the usefulness of the framework. New tools and updates such as NCBI BLAST+, Inter-ProScan 5 and PfamScan, new categories such as RNA analysis tools (https://www.ebi.ac.uk/Tools/ rna/), new databases such as ENA non-coding, WormBase ParaSite, Pfam and Rfam, and new workflow methods, together with the retirement of depreciated services, ensure that the framework remains relevant to today's biological community.
Structural and Functional Characterization of Potent Antithrombotic Oligonucleotides Possessing Both Quadruplex and Duplex Motifs (1995)

We report the results of a selection for single-stranded DNA oligonucleotide ligands to the serine protease thrombin using recently developed methods. This selection yielded a family of DNA sequences that conform to a consensus structure comprised of a unimolecular quadruplex motif and complementary flanking sequences capable of forming an additional Watson-Crick duplex motif. This novel quadruplex/duplex structure was not reported in a previous selection for DNA molecules which bind to thrombin [Bock et al. (1992) Nature 355, 564-566]. All quadruplex/duplex molecules tested bound to thrombin with higher affinity than quadruplex structures lacking the duplex structure. However, binding affinities did not always correlate with inhibitory potency since some molecules with high affinity were not potent inhibitors in vitro. 1H NMR spectroscopy studies demonstrated that the complementarity of bases in the duplex portion of a selected sequence allows it to form multimolecular structures. Constraining these molecules to the unimolecular quadruplex/duplex structure by bridging the 5' and 3' ends of the duplex motif with either triethylene glycol or disulfide bonds improved their thrombin inhibitory activity. All bridged quadruplex/duplex molecules were more potent inhibitors than molecules with only a quadruplex motif. Bridging the ends of these structures not only increased thrombin inhibition but also improved resistance to nucleases in serum more than 40-fold over the unbridged quadruplex. In addition, we have found that both the length and sequence of the duplex motif are important for inhibition.
The Consequences of Uncontrolled Epilepsy (2004)

The consequences of epilepsy can be quite severe and include shortened lifespan, excessive bodily injury, neuropsychological and psychiatric impairment, and social disability. There is evidence that seizures cause brain injury, including neuronal death and physiological dysfunction. Mortality rates are 4-7 times higher in people with medically refractory seizures, and injury rates are substantial, ranging from one per 20 person-years to as much as one per 3 person-years. Quality of life is impaired in epilepsy, and relates to seizure control. Psychosocial disabilities, including lower social interaction with reduced marriage rates and reduced employment levels, are more common in people with refractory seizures. Complete seizure control is desirable, since seizures potentially constitute a serious threat to health and well-being. Therefore, satisfactory seizure control should be defined as having no seizures. Treatment should be directed to preventing seizures whenever possible and achieving control early in the course of illness. The risks of uncontrolled seizures outweigh the risks of aggressive medical or surgical therapy.