gebhart/patrepeval huggingface dataset:
Receptor tyrosine kinase signaling in vascular development. (1997)

The formation and maintenance of the vascular circulatory system is of utmost importance during embryonic and postnatal life. The first organ system to develop is the cardiovascular network of endothelial cells that carry blood cells and metabolites throughout the embryo (1 , 2). Indeed, a functional vascular system is crucial for the rapid growth of postimplantation embryos. The vascular system is highly dynamic throughout life and is able to generate new capillary endothelial cell networks as required, such as in wound healing and in the cyclic neovascularization of the ovarian follicle (corpus luteum) and endometrium. Diseases of the cardiovascular system, including those of the heart and blood vessels, are a major cause of pathological conditions affecting humans. Moreover, many cancer cells secrete angiogenic factors that attract endothelial cells to neovascuIarize and divert blood flow into solid tumors (3, 4). Abnormal angiogenesis is also observed in nonneoplastic conditions, including diabetic retinopathy, rheumatoid arthritis, and psoriasis (4). Our ability to understand the biochemical mechanisms that govern and control vascular endothelial cells are thus essential to the development of new therapies to help combat such disorders. Endothelial cells must respond to a diverse array of p0tential signals and initiate downstream intracellular pathways that can affect their fate, proliferation, transcription, migration, adherence, and permeability. Some of these signals may be elicited by transmembrane RTKs,3 because a select group of these molecules are expressed at high levels primarily in cells ofthe endothelial lineage, including FIk-1/KDR, FIt-i , FIt-4, Tie-i , and Tie-2/Tek (5). Furthermore, a family of growth factors that act specifically on endothelial cells, VEGFs, have been identified as ligands capable of stimulating the tyrosine kinase activity of the FIk-1 , Fit-i , and FIt-4 receptors. In this review, we describe recent genetic studies in mice that directly implicate signaling pathways activated
Oxidative Stress Associated with Neuronal Apoptosis in Experimental Models of Epilepsy (2014)

Epilepsy is considered one of the most common neurological disorders worldwide. Oxidative stress produced by free radicals may play a role in the initiation and progression of epilepsy; the changes in the mitochondrial and the oxidative stress state can lead mechanism associated with neuronal death pathway. Bioenergetics state failure and impaired mitochondrial function include excessive free radical production with impaired synthesis of antioxidants. This review summarizes evidence that suggest what is the role of oxidative stress on induction of apoptosis in experimental models of epilepsy.
Off-line coupling of a microbore high-performance liquid chromatograph to a secondary ion time-of-flight mass spectrometer (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOff-line coupling of a microbore high-performance liquid chromatograph to a secondary ion time-of-flight mass spectrometerR. C. Beavis, W. Ens, D. E. Main, and K. G. StandingCite this: Anal. Chem. 1990, 62, 13, 1259–1264Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/ac00212a012https://doi.org/10.1021/ac00212a012research-articleACS PublicationsRequest reuse permissionsArticle Views35Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparing Containers versus Virtual Machines for Achieving High Availability (2015)

In recent decades, virtualization as an abstraction from physical hardware has become a popular solution to resource isolation and server consolidation. With the surge in adoption of virtualization technologies, ensuring High Availability (HA) for applications hosted in virtualized environments emerges as an important problem and has garnered substantial attention. In this paper, we present a brief comparison of virtualization technologies from a HA perspective. The state-of-the-art HA solutions in two mainstream types of virtualized platforms (i.e., hypervisor-based platform and container-based platform) are respectively investigated in terms of limitations and features such as live migration, failure detection, and checkpoint/ restore. One of our key findings is that, compared with hypervisor-based platforms, HA features in container-based platforms are far from enough. From a HA perspective, extensions on top of container technologies are required.
New high temperature stable positive photoresists based on hydroxy polyimides and polyamides containing the hexafluoroisopropylidene (6‐f) linking group (1989)

Abstract In this paper we describe the synthesis, characterization, and lithographic evaluations of novel positive photoresists based on hydroxy polyimides and polyamides containing 6‐F linking groups. The polymers were synthesized using solution condensation techniques and characterized using solution viscosity, GPC, FTIR, NMR, UV, TGA, and DSC. T g 's of these polymers range from 250 to 300°C. Both polyimides and polyamides are soluble in a variety of solvents commonly utilized for photoresist applications. When formulated with diazonaphthoquinone sensitizers, these polymers provide an improved high‐temperature resistant, aqueous base developable positive photoresist system with good photospeed, contrast, and resolution characteristics. High resolution relief images were obtained which are comparable to 1300 Series AZ type photoresists. No thermal deformation, loss in resolution or defects were noticed when relief patterns were annealed to 250°C. Additionally, the hydroxy polyamide based resists, when thermally annealed to 300°C, provide a photoresist system with even higher thermal stability (400 to 450°C) and excellent resistance to solvents. Also, the photoresist formulations have excellent storage stability at room temperature and can be processed like conventional positive photoresists using broad band UV radiation sources.
Organization of Mouse Iroquois Homeobox Genes in Two Clusters Suggests a Conserved Regulation and Function in Vertebrate Development (2000)

Iroquois proteins comprise a conserved family of homeodomain-containing transcription factors involved in patterning and regionalization of embryonic tissues in both vertebrates and invertebrates. Earlier studies identified four murine Iroquois (Irx) genes. Here we report the isolation of two additional members of the murine gene family, Irx5 and Irx6. Phylogenetic analysis of the Irx gene family revealed distinct clades for fly and vertebrate genes, and vertebrate members themselves were classified into three pairs of cognate genes. Mapping of the murine Irx genes identified two gene clusters located on mouse chromosomes 8 and 13, respectively. Each gene cluster is represented by three Irx genes whose relative positions within both clusters are strictly conserved. Combined results from phylogenetic, linkage, and physical mapping studies provide evidence for the evolution of two Irx gene clusters by duplication of a larger chromosomal region and dispersion to two chromosomal locations. The maintenance of two cognate Irx gene clusters during vertebrate evolution suggests that their genomic organization is important for the regulation, expression, and function of Irx genes during embryonic development.
Knowledge of and attitude towards circumcision of adult Korean males by age (2004)

Aim : Circumcision is widely practised in Korea, but little is known regarding the public's attitude towards circumcision. This study was designed to evaluate the knowledge and the general opinion of Korean adult males towards circumcision. Methods : Fifteen hundred self‐completion questionnaires were distributed to adult males in five decadal age groups ranging from 10 to 59 y old. Questions concerning opinions regarding the necessity, reasons, potential benefits and disadvantages of circumcision, as well as the role of peer pressure upon the decision to circumcise were included. Completed questionnaires were collected and analysed statistically. Results : The achieved response rate was 62.7%. 73.1% believed that circumcision is necessary, while 7.1% believed it is not necessary. The principal reason for circumcision was to improve penile hygiene (77.9%). 68.7% did not prefer neonatal circumcision regardless of the respondent's age. The major reason was fear of pain (36.9%). Peer pressure was one of the most influential factors when deciding upon circumcision: 60.8% believed that they might be ridiculed by their peer group unless circumcised, and the younger the age of the respondent, the more frequently this opinion was held ( p &gt; 0.05). 62.7% thought that circumcision would prevent genital tract infection of the sexual partner. Respondents with older age tended to emphasize improved sexual potency ( p &gt; 0.05). Conclusions : This study indicates that common beliefs of adult males about circumcision in Korea are relatively homogeneous. Tailored education about circumcision is needed.
Nuclear transfer in rodents (2003)

Cloning is the asexual reproduction of an individual, such that the offspring have an essentially identical nuclear genome. Nuclear transfer and cloning have been achieved in a number of species, namely sheep, cows, goats, rabbits, cats and mice, but have been largely unsuccessful, so far, in dogs, primates and rats. Clearly, contributory factors which affect the outcome of successful cloning experiments are not universally applicable to all species. One theme common to all cloning experiments, however, is the overall inefficiency of the process, typically 0-4%. A number of factors contribute to nuclear transfer inefficiency, and we will review mouse cloning experiments, which address these problems, highlighting the importance of donor nucleus choice (somatic or ES cell, fetal or adult, quiescent or actively dividing). Finally, we will summarize the emerging principles which appear to govern nuclear reprogramming and production of clones, and will consider the application of nuclear transfer to the rat.
Induction of Interleukin-12 and Gamma Interferon Requires Tumor Necrosis Factor Alpha for Protective T1-Cell-Mediated Immunity to PulmonaryCryptococcus neoformansInfection (2002)

The development of T1-cell-mediated immunity is required to clear a pulmonary Cryptococcus neoformans infection. The objective of these studies was to determine the mechanism by which tumor necrosis factor alpha (TNF-alpha) augments the development of pulmonary T1 immunity to C. neoformans infection. TNF-alpha expression was detected in lavage sample cells at days 2, 3, and 7 following C. neoformans infection. The numbers of CFU in the lung were not different between control and anti-TNF-alpha-treated mice at any time point examined during the afferent phase of the response (days 0 to 7). However, neutralization of TNF-alpha prevented the initiation of pulmonary clearance during the efferent phase of the response (day 14). Administration of anti-TNF-alpha monoclonal antibody (day 0) diminished the lung levels of TNF-alpha, interleukin-12 (IL-12), and gamma interferon (IFN-gamma) induced by C. neoformans at day 7 postinfection. Neutralization of TNF-alpha (day 0) also altered the IFN-gamma/IL-4 ratio in the lung-associated lymph nodes at day 7 following C. neoformans infection. Anti-TNF-alpha-treated mice developed a pulmonary eosinophilia at day 14 postinfection. Consistent with the pulmonary eosinophilia, anti-TNF-alpha-treated mice exhibited elevated serum immunoglobulin E and inhibition of the anticryptococcal delayed-type hypersensitivity response, indicating a shift toward a T2 response. Neutralization of IL-12 also prevented lung leukocyte production of IFN-gamma in response to the infection. These findings demonstrate that afferent-phase TNF-alpha production is essential for the induction of IL-12 and IFN-gamma and neutralization of early TNF-alpha results in a T2 shift of the T1/T2 balance of antifungal immunity.
Issues in data embedding and synchronization for digital television (2002)

As digital television matures, applications which utilize data embedded in the broadcast television signal are likely to be an important feature of the new medium. The paper explores some of the issues involved in the implementation of systems for the utilization of data which accompanies digital television's video and audio content. Chief among these issues are those which pertain to: (i) how data can be embedded into the television signal in ways which utilize bandwidth and buffer space efficiently; (ii) how the embedded data can be synchronized with its associated video and audio content.
Functional Roles of STAT Family Proteins: Lessons from Knockout Mice (1999)

STAT (signal transducers and activators of transcription) proteins are activated in response to a large number of cytokines, growth factors, and hormones. Upon activation following the binding of ligands to their receptors, STAT proteins dimerize, translocate to the nucleus, and bind to the promoters of specific target genes. To date, seven mammalian members of the STAT family have been identified. Although some cytokines and growth factors can activate multiple STAT proteins, some STATs are activated with considerable specificity. The physiological role of each individual STAT protein is now being examined through the study of "knockout" mice, harboring a null allele for the particular gene. STAT1-deficient mice exhibit a selective signaling defect in response to interferons. STAT4 and STAT6 are essential for Thl-and Th2-responses, respectively. STAT5a-deficient mice exhibit defective mammary gland development. A study of STAT5b-deficient mice indicates that STAT5b mediates the sexually dimorphic effects of growth hormone in the liver. STAT5a and 5b also play different biological roles in the immune system. STAT3-deficient mice die during early embryogenesis, but the role of STAT3 in adult tissues can be assessed by utilizing the CreloxP recombination system to ablate the gene later in life. Analyses of tissue-specific STAT3-deficient mice indicate that STAT3 plays a crucial role in a variety of biological functions, including cell growth, suppression of apoptosis, and cell motility.
Simple Chemical Transformation of Lignocellulosic Biomass into Furans for Fuels and Chemicals (2009)

Lignocellulosic biomass is a plentiful and renewable resource for fuels and chemicals. Despite this potential, nearly all renewable fuels and chemicals are now produced from edible resources, such as starch, sugars, and oils; the challenges imposed by notoriously recalcitrant and heterogeneous lignocellulosic feedstocks have made their production from nonfood biomass inefficient and uneconomical. Here, we report that N,N-dimethylacetamide (DMA) containing lithium chloride (LiCl) is a privileged solvent that enables the synthesis of the renewable platform chemical 5-hydroxymethylfurfural (HMF) in a single step and unprecedented yield from untreated lignocellulosic biomass, as well as from purified cellulose, glucose, and fructose. The conversion of cellulose into HMF is unabated by the presence of other biomass components, such as lignin and protein. Mechanistic analyses reveal that loosely ion-paired halide ions in DMA-LiCl are critical for the remarkable rapidity (1-5 h) and yield (up to 92%) of this low-temperature (<or=140 degrees C) process. The simplicity of this chemical transformation of lignocellulose contrasts markedly with the complexity of extant bioprocesses and provides a new paradigm for the use of biomass as a raw material for a renewable energy and chemical industries.
Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteinsRichard D. Cramer, David E. Patterson, and Jeffrey D. BunceCite this: J. Am. Chem. Soc. 1988, 110, 18, 5959–5967Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/ja00226a005https://doi.org/10.1021/ja00226a005research-articleACS PublicationsRequest reuse permissionsArticle Views4288Altmetric-Citations3342LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Structure and physiological function of calpains (1997)

For a long time now, two ubiquitously expressed mammalian calpain isoenzymes have been used to explore the structure and function of calpain. Although these two calpains, mu- and m-calpains, still attract intensive interest because of their unique characteristics, various distinct homologues to the protease domain of mu- and m-calpains have been identified in a variety of organisms. Some of these 'novel' calpain homologues are involved in important biological functions. For example, p94 (also called calpain 3), a mammalian calpain homologue predominantly expressed in skeletal muscle, is genetically proved to be responsible for limb-girdle muscular dystrophy type 2A. Tra-3, a calpain homologue in nematodes, is involved in the sex determination cascade during early development. PalB, a key gene product involved in the alkaline adaptation of Aspergillus nidulans, is the first example of a calpain homologue present in fungi. These findings indicate various important functional roles for intracellular proteases belonging to the calpain superfamily.
The kallikrein-kinin system as mediator in vasogenic brain edema (1984)

Plasma and bradykinin were perfused into the ventricular system of mongrel dogs to investigate whether either or both induce brain edema. Formation of cerebral edema was determined by measurement of cerebral water and electrolytes in periventricular white matter, cerebral cortex, and caudate nucleus. The response of cerebral tissue to exposure to bradykinin or to plasma, as a carrier of kininogens, was analyzed by assessment of the perfusate composition after ventricle passage. The authors report that cerebral administration of bradykinin induces cerebral edema. Ventricular perfusion with plasma also led to an increase of cerebral water content which was restricted to the white matter, but involved all brain tissue areas, if bradykinin was used. Ventricular perfusion with plasma was associated with consumption of the kinin precursor (kininogens) indicative of formation of kinins. Significant consumption of the precursor was found in five out of nine animals subjected to plasma perfusion of the ventricular system. In these animals a close correlation between the increase of white matter water content and kininogen-consumption as a measure of kinin-formation was obtained. Marked kinin-degrading activity was observed during ventricular perfusion with bradykinin as concluded from a considerable decrease of bradykinin concentration in the cisternal effluent compared to the inflowing perfusate concentration. Ventricular perfusion with plasma was associated with a decrease of K+ clearance capacity with continued duration, and in two animals with a release of glutamate into the plasma perfusate, suggesting an involvement of cytotoxic mechanisms. These findings provide support for the hypothesis of a mediator function of the kallikrein-kinin (KK) system in vasogenic brain edema. The next question that needs to be answered to complete the picture--does spontaneous activation of the KK system occur in conditions leading to vasogenic edema?--is studied in a subsequent report.
Characterization of a pseudorabies virus glycoprotein gene with homology to herpes simplex virus type 1 and type 2 glycoprotein C (1986)

A pseudorabies virus (Becker strain) glycoprotein gene was located in the UL region at map position 0.40. The gene was identified by using open reading frame Escherichia coli plasmid expression vectors and specific antibody reagents. A 1.55-kilobase unspliced transcript from the gene was detected in pseudorabies virus-infected tissue culture cells. The DNA sequence revealed a single open reading frame of 1,437 base pairs encoding 479 amino acids. The predicted primary translation product has a molecular weight of 50,860 and contains features of a typical herpesvirus glycoprotein. An E. coli expression plasmid was constructed that contained essentially all of the open reading frame for this gene. Antibodies raised in rabbits against the protein expressed in bacteria by this plasmid immunoprecipitated pseudorabies virus-specific glycoproteins of 92,000 and 74,000 daltons from infected cell extracts. It is likely that these two forms represent different glycosylation states of the protein.