gebhart/patrepeval huggingface dataset:
Lateral extracavitary approach to traumatic lesions of the thoracic and lumbar spine (1976)

The lateral extracavitary approach to the spine was used for resection of displaced bpne and disc located anterior to the dura in 62 patients with traumatic lesions of the thoracic and lumbar spine. Fifty-two patients had closed vertebral fractures and 10 had gunshot wounds. The spinal cord was involved in 44 patients, and the cauda equina in 18. A spinal subarachnoid block was demonstrated in 17 of 57 preoperative gas myelograms. Evoked potential recordings, although related to preception of joint rotation, tended to reflect the overall neurological condition and had some prognostic value. Significant improvement followed surgery in 46 patients with incomplete neurological lesions, and one was transiently worse. Before operation 18 patients were able to walk; nine with assistance and nine without. After operation 47 patients were able to walk; 12 with assistance and 35 without. Adequate bladder function was present in 17 patients before surgery, and in 44 after surgery. A laminectomy had been done previously in 16 patients, 11 of whom improved significantly after anterior resection. Spine fusions were required in 26 patients, five of whom had a prior laminectomy. The major factor in the pathogenesis of the incomplete neurological deficit appeared to be distortion of the cord and roots by displaced bone and disc. Consequently, the primary object of treatment was the restoration and maintenance of normal anatomical relationships between the spinal cord or cauda equina and the spinal canal.
LHC Run 2: Results and Challenges (2016)

The first proton run of the LHC was very successful and resulted in important physics discoveries. It was followed by a two-year shutdown where a large number of improvements were carried out. In 2015, the LHC was restarted and this second run aims at further exploring the physics of the standard model and beyond at an increased beam energy. This article gives a review of the performance achieved so far and the limitations encountered, as well as the future challenges for the CERN accelerators to maximize the data delivered to the LHC experiments in Run 2. Furthermore, the status of the 2016 LHC run and commissioning is discussed.
Shaped Input Control of a System With Multiple Modes (1993)

This paper describes a method for limiting vibration in flexible systems that have more than one characteristic frequency and mode. It is only necessary to have knowledge of the component mode frequencies and damping ratios in order to be able to calculate the timing and magnitudes of the impulse sequence used in the shaping. Only two impulses, in the nonrobust case, or three impulses in a more robust case, are necessary regardless of the number of component frequencies. Simple tests are established to determine when this technique can be used and examples are presented.
Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels. (1998)

Sulfonylureas stimulate insulin secretion from pancreatic beta-cells by closing ATP-sensitive K+ (K(ATP)). The beta-cell and cardiac muscle K(ATP) channels have recently been cloned and shown to possess a common pore-forming subunit (Kir6.2) but different sulfonylurea receptor subunits (SUR1 and SUR2A, respectively). We examined the mechanism underlying the tissue specificity of the sulfonylureas tolbutamide and glibenclamide, and the benzamido-derivative meglitinide, using cloned beta-cell (Kir6.2/SUR1) and cardiac (Kir6.2/SUR2A) K(ATP) channels expressed in Xenopus oocytes. Tolbutamide inhibited Kir6.2/SUR1 (Ki approximately 5 micromol/l), but not Kir6.2/SUR2A, currents with high affinity. Meglitinide produced high-affinity inhibition of both Kir6.2/SUR1 and Kir6.2/SUR2A currents (Kis approximately 0.3 micromol/l and approximately 0.5 micromol/l, respectively). Glibenclamide also blocked Kir6.2/SUR1 and Kir6.2/SUR2A currents with high affinity (Kis approximately 4 nmol/l and approximately 27 nmol/l, respectively); however, only for cardiac-type K(ATP) channels was this block reversible. Physiological concentrations of MgADP (100 micromol/l) enhanced glibenclamide inhibition of Kir6.2/SUR1 currents but reduced that of Kir6.2/SUR2A currents. The results suggest that SUR1 may possess separate high-affinity binding sites for sulfonylurea and benzamido groups. SUR2A, however, either does not possess a binding site for the sulfonylurea group or is unable to translate the binding at this site into channel inhibition. Although MgADP reduces the inhibitory effect of glibenclamide on cardiac-type K(ATP) channels, drugs that bind to the common benzamido site have the potential to cause side effects on the heart.
Digital predistortion for hybrid precoding architecture in millimeter-wave massive mimo systems (2017)

Millimeter-wave (mmWave) systems require massive antennas at both transmitter and receiver to reach desirable link budget. Analog-digital hybrid beamforming is a promising architecture since it significantly reduces the hardware cost while approaches the performance of digital beamforming. However, the nonlinear power amplifier (PA) introduces intermodulation interference and degrades the spectral efficiency. In this work, we use memory polynomial model for modelling mmWave PA and study the inter-beam and inter-symbol interference in hybrid precoding architecture. We also propose a digital predistortion (DPD) algorithm to mitigate interference. The proposed DPD reduces interference power by an order of magnitude and compared with system without predistortion, the proposed system can achieve up to 60% spectral efficiency.
Effect of Candida colonization on human ulcerative colitis and the healing of inflammatory changes of the colon in the experimental model of colitis ulcerosa. (2009)

The influence of fungal colonization on the course of ulcerative colitis (UC) has not been thoroughly studied. We determined the activity of the disease using clinical, endoscopic and histological index (IACH) criteria in UC patients with fungal colonization and the healing process of UC induced by an intrarectal administration of trinitrobenzene sulfonic acid (TNBS) in rats infected with Candida, without and with antifungal (fluconazole) or probiotic (lacidofil) treatment. The intensity of the healing of the colonic lesions was assessed by macro- and microscopic criteria as well as functional alterations in colonic blood flow (CBF). Myeloperoxidase (MPO) content and plasma proinflammatory cytokines IL-1beta and TNF-alpha levels were evaluated. Candida more frequently colonized patients with a history of UC within a 5-year period, when compared with those of shorter duration of IBS. Among Candida strains colonizing intestinal mucosa, Candida albicans was identified in 91% of cases. Significant inhibition of the UC activity index as reflected by clinical, endoscopical and histological criteria was observed in the Candida group treated with fluconazole, when compared to that without antifungal treatment. In the animal model, Candida infection significantly delayed the healing of TNBS-induced UC, decreased the CBF and raised the plasma IL-1beta and TNF-alpha levels, with these effects reversed by fluconazole or lacidofil treatment. We conclude that 1) Candida delays healing of UC in both humans and that induced by TNBS in rats, and 2) antifungal therapy and probiotic treatment during Candida infection could be beneficial in the restoration and healing of colonic damage in UC.
Use of specific endonuclease cleavage in RNA sequencing (1977)

Nonradioactive RNA fragments may be sequenced by incorporation of (3H)-label into 3'-terminal positions, controlled digestion with specific ribonucleases, and separation according to size of the digestion products on polyethyleneimine- (PEI-) cellulose thin layers. This combination of techniques allows one to measure accurately distances of specific cleavage sites from the labeled terminal positions. The cleavage specificities of RNases T1, U2, and A are utilized to identify the positions of G, A, and pyrimidine residues respectively. C and U may be distinguished by mobility differences on PEI-cellulose thin layers at ph 2.6. The procedure is simple, rapid, and highly sensitive; as little as 0.5 - 1 microgram of a RNA of the size of tRNA will be needed to sequence all fragments in a complete RNase digest.
Real‐Time Consensus‐Based Scene Reconstruction Using Commodity Graphics Hardware† (2003)

Abstract We present a novel use of commodity graphics hardware that effectively combines a plane‐sweeping algorithm with view synthesis for real‐time, online 3D scene acquisition and view synthesis. Using real‐time imagery from a few calibrated cameras, our method can generate new images from nearby viewpoints, estimate a dense depth map from the current viewpoint, or create a textured triangular mesh. We can do each of these without any prior geometric information or requiring any user interaction, in real time and online. The heart of our method is to use programmable Pixel Shader technology to square intensity differences between reference image pixels, and then to choose final colors (or depths) that correspond to the minimum difference, i.e. the most consistent color. In this paper we describe the method, place it in the context of related work in computer graphics and computer vision, and present some results. ACM CSS: I.3.3 Computer Graphics— Bitmap and framebuffer operations , I.4.8 Image Processing and Computer Vision— Depth cues, Stereo
Regulation of Ovarian Steroid Biosynthesis by Estrogen during Proestrus in the Rat* (1991)

Studies were performed to test the hypothesis that the rapid decline in estradiol (E2) levels on proestrus before ovulation was due to a reduction in androgen substrate for aromatase, and that this decline in androgen was regulated by an estrogen receptor-mediated mechanism. Aromatase activity, concentrations of E2, androstenedione (A), testosterone (T), and progesterone (P4) in follicular, corpora lutea, and ovarian homogenates as well as peripheral E2, A, P4, and LH were measured in cycling rats from 1400-2000 h on proestrus. These parameters were also recorded after the expected E2 surge in animals treated at 1900 h on diestrous day 2 with the antiestrogen keoxifene (20 mg/kg), with or without an ovulatory dose of PMSG at 1600 h on proestrus. In a second experiment, P-450-17 alpha-hydroxylase/C17,20-lyase (P-450(17 alpha] activity was measured in a group of control rats at 1500, 1700, and 1900 h. Aromatase activity remained unchanged, even though serum and ovarian E2 levels were reduced from peak values at 1500 h to basal values at 1800 h (P less than 0.01). Peripheral A as well as ovarian androgens (specifically follicular but not luteal) A and T were also reduced over this time period (P less than 0.01). Although total ovarian P4 remained unchanged, follicular levels rose from 1400-2000 h (P less than 0.01). These reductions in androgens and E2 levels coincided with a marked reduction in follicular P-450(17 alpha) activity. Treatment with keoxifene with or without PMSG prevented the fall in peripheral E2 and A and the increase in peripheral P4 seen in controls. Ovarian and follicular E2, A, and to a lesser extent T were also remained at values similar to those during the E2 surge. Follicular P4 was reduced by both treatments. Neither treatment had any effect on aromatase. These results indicate that the fall in peripheral and ovarian E2 levels before ovulation was due to a decline in aromatizable androgen, through an inhibition of follicular P-450(17 alpha) enzyme activity, which appears to be mediated by an estrogen receptor-regulated mechanism.
DETERMINATION OF ELECTRICAL PROPERTIES OF THE GROUND AT SHALLOW DEPTH WITH AN ELECTROSTATIC QUADRUPOLE: FIELD TRIALS ON ARCHAEOLOGICAL SITES1 (1993)

A bstract Knowledge of both the electrical resistivity ρ and the dielectric permittivity ɛ of the ground is important for the determination of characteristics such as granularity, porosity, moisture and salt content. Whereas the measurement of ρ is very common and can be achieved using either the d.c. resistivity method or a wide variety of EM devices, ɛ remains practically unknown in the low‐frequency domain between the IP domain and the high‐frequency domain. Following the principle of the quadrupole technique used in d.c. prospecting and of the quadrupolar probe for measuring the complex permittivity of the ionosphere, we propose a new approach which does not require any galvanic contact between the poles and the ground. The transfer impedance can be evaluated using the quasi‐static approximation for low frequency or the full EM theory for higher frequencies. The conditions under which both calculations apply are discussed. At low frequencies and for low resistivity ground, the electrostatic quadrupole measures ρ exactly as with the d.c. technique; for higher resistivities or frequencies the simultaneous measurement of both properties becomes possible. Examples in archaeological prospecting are presented and checked against independent d.c. resistivity measurements or excavation analyses.
RNAi As a Treatment for HIV-1 Infection (2006)

Human immunodeficiency virus type 1 (HIV-1) was the first primate virus shown to be inhibited by RNA interference (RNAi). Early studies used both synthetic and promoter expressed small interfering RNAs (siRNAs) or expressed short hairpin RNAs (shRNAs) to demonstrate that this virus was susceptible to RNAi. In addition to targeting the virus itself RNAi-mediated down-regulation of cellular targets that encode receptors required for viral entry also proved to be effective. The power of RNAi as an anti-HIV agent has propelled development of RNAi-based gene therapy approaches for the treatment of HIV infection in humans. Nevertheless, extensive in vitro experimentation has revealed potential problems of viral escape mutants and other toxicities caused by the si/shRNAs. This review covers the progress and problems in the development of RNAi for the treatment of HIV infection. Potential modalities for clinical application of RNAi in the treatment of HIV-1 infection are also described.
The effect of high‐pressure food processing on the sorption behaviour of selected packaging materials (2004)

Abstract The sorption behaviour and flavour‐scalping potential of selected packaging films in contact with food simulant liquids (FSLs) (ethanol and acetic acid solutions) were evaluated after high‐pressure processing (HPP). The films used were monolayer polypropylene (PP), a multilayer (polyethylene/nylon/ethylene vinyl alcohol/polyethylene: PE/nylon/EVOH/PE), film and a metallized (polyethylene terephthalate/ethylene–vinyl acetate/linear low‐density polyethylene: metallized PET/EVA/LLDPE) material. D‐limonene was used as the sorbate and was added to each of the FSLs. After HPP treatment at 800 MPa, 10 min, 60°C, the amount of D‐limonene sorbed by the packaging materials and the amount remaining in the FSL was measured. Untreated controls (1 atm, 60°C and 40°C) were also prepared. Extraction of the D‐limonene from the films was performed using a purge/trap method. D‐limonene was quantified in both the films and the FSL, using gas chromatography (GC). The results showed that D‐limonene concentration, in both the films and the food simulants, was not significantly affected by HPP, except for the metallized PET/EVA/LLDPE. Significant differences in D‐limonene sorption were found in comparison with the control pouches. The results also showed that changes in temperature significantly affected the sorption behaviour of all films. Copyright © 2004 John Wiley &amp; Sons, Ltd.
Improved Conditions for Solid Phase Synthesis of Oligonucleotides on PS-PEG Copolymers (1995)

Polystyrene-polyethylene glycol (PS-PEG) tentacle polymers with loadings of up to 60/&lt;μmol/g were used for standard oligonucleotide synthesis. As these resins are easy to handle and stable under reaction and cleavage conditions they may be used alternatively to controlled pore glass (CPG) as the most commonly used solid support for oligonucleotide synthesis. However, structural and chemical properties of the PS-PEG resins require modified conditions to guarantee syntheses with high coupling efficiencies. Oligonucleotides (ODN ) of various sequences and lengths have successfully been synthesized using HPLC and capillary electrophoresis (CE) for purity control. Additionally, electrospray mass spectrometry (ES-MS) was used for product identification.
A Wideband Wireless Micro-Stimulating AISC for Cochlear Implant (2006)

This paper presents a wireless micro-stimulating ASIC for cochlear prosthesis application, to restore auditory function in profoundly deaf individuals. A new wideband frequency-shift keying (FSK) demodulator is designed to guarantee the high bandwidth of the digital data transmission chain. The demodulator circuit derives a constant frequency clock from FSK carrier directly, and uses this clock to sample the data bits. The circuit is experimentally tested at the stimulus rate up to 75k pulses per second with transmission speed of 2.5Mbps while receiving a 5M/10MHz FSK carrier signal. The whole circuit occupies 7.5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> in a 0.6 μm, 2M/2P, standard CMOS process, and consumes 12.5mW at 5V.
Optimized piezoelectric energy harvesting circuit using step-down converter in discontinuous conduction mode (2003)

An optimized method of harvesting vibrational energy with a piezoelectric element using a step-down DC-DC converter is presented. In this configuration, the converter regulates the power flow from the piezoelectric element to the desired electronic load. Analysis of the converter in discontinuous current conduction mode results in an expression for the duty cycle-power relationship. Using parameters of the mechanical system, the piezoelectric element, and the converter an optimal duty cycle can be determined where the harvested power is maximized for a given frequency of mechanical excitation. It is shown that, as the magnitude of the excitation increases, the optimal duty cycle becomes essentially constant, greatly simplifying the control of the step-down converter. The expression is validated with experimental data showing that the optimal duty cycle can be accurately determined and maximum energy harvesting attained. A circuit is proposed which implements this relationship, and experimental results show that the converter increases the harvested power by approximately 325%.
Alkaline decontamination of sputum specimens adversely affects stability of mycobacterial mRNA (1996)

Reverse transcriptase PCR (RT-PCR) is an important tool for Mycobacterium tuberculosis research and diagnostics. A standard procedure using N-acetyl-L-cysteine (NALC) and NaOH has been widely adopted for digestion and decontamination of sputum specimens for mycobacterial culture. The objective of this study was to determine the compatibility of this method with the recovery of RNA for RT-PCR assays. Nineteen sputum specimens were collected from smear-positive, pretreatment tuberculosis patients. After homogenization with NALC and glass beads, specimens were further processed by the addition of either NaOH, as per the standard decontamination protocol, or phosphate buffer. RNA was prepared by using a modified guanidine-phenol extraction method developed specifically for sputum sediments. DNA was isolated from the same specimens. Reverse transcriptions of alpha antigen (85B protein) mRNA and 16S rRNA were performed together, and aliquots were removed for separate PCRs. In all specimens, the 85B mRNA target was greatly diminished by treatment with NaOH; however, the 16S rRNA target remained unaffected. Storing sputum specimens for 48 h at 4 degrees C before processing did not seem to affect the integrity or yield of RNA; however, some degradation occurred by 72 h. Data suggest that the NaOH-NALC method for processing sputum samples is not suitable for detecting mRNA targets in RT-PCR assays.
Chronic Vitamin E Administration Improves Brachial Reactivity and Increases Intracellular Magnesium Concentration in Type II Diabetic Patients (2000)

Vascular disease accounts for the majority of the clinical complications in diabetes mellitus. As an exaggerated oxidative stress degree has been postulated as the link between diabetes mellitus and endothelial function, a possible positive effect of plasma vitamin E (Vit.E) administration on brachial reactivity could be postulated. Our study aims at investigating the possible effect of chronic Vit.E administration on brachial reactivity, oxidative stress indexes, and intracellular magnesium and calcium content in type II diabetic patients free of diabetic complications. Forty adult, type II diabetic patients were enrolled in the study, which was deigned as a double blind, randomized vs. placebo trial. At baseline all patients underwent the following tests: 1) anthropometric and metabolic examinations, 2) evaluation of oxidative stress indexes, 3) intracellular magnesium and calcium measurements, and 4) determination of arterial compliance and distensibility. Then, all patients were randomly assigned to Vit.E treatment at a dose of 600 mg/day (Evion Forte; n = 20) or placebo (n = 20) over 8 weeks. At the end of this treatment period, a complete reevaluation of the patients was made. Vit.E treatment was associated with a significant improvement in the percent change in brachial artery diameter (P<0.03) and oxidative stress indexes (P< 0.005). In the Vit.E group, the percent change in brachial artery diameter correlated positively with the percent change in oxidative stress indexes (oxidized/reduced glutathione, Trolox-equivalent antioxidant capacity, thiobarbituric acid reaction products, lipid peroxides) and intracellular cation content (magnesium and calcium). After adjustment for age, sex, body mass index, and wait/hip ratio, all of these correlations remained significant (P<0.03 for all). Furthermore, adjusting for glycosylated hemoglobin, plasma total cholesterol, and homeostatic model index, brachial artery diameter was still correlated with the percent change in oxidative stress indexes (P<0.04 for all). Nevertheless, the relationship between the percent change in brachial artery diameter and oxidative stress indexes was no longer significant after adjustment for intracellular Mg and Ca2+. In conclusion, our study demonstrates that chronic administration of Vit.E improves brachial artery reactivity in patients with type II diabetes mellitus. Such an effect seems mediated by a reduction in oxidative stress and a regulation of intracellular calcium and magnesium contents.
The use of surgical sympathectomy in the treatment of chronic renal pain (1997)

Renal denervation cures severe intractable pain in about 25% of patients. Recurrence of pain could be prevented in more patients if there was a way of preventing re-innervation.
Enabling Focus Cues in Head-Mounted Displays (2017)

Developing head-mounted displays (HMDs) that offer uncompromised optical pathways to both digital and physical worlds without encumbrance and discomfort confronts many grand challenges, both from technological perspectives and human factors. Among the many challenges, minimizing visual discomfort is one of the key obstacles. One of the key contributing factors to visual discomfort is the lack of the ability to render proper focus cues in HMDs to stimulate natural eye accommodation responses, which leads to the wellknown problem of vergence-accommodation conflict. This paper provides a comprehensive summary of various technical approaches toward enabling focus cues in HMDs for both virtual reality (VR) and augmented reality (AR) applications.