gebhart/patrepeval huggingface dataset:
Phosphatidylethanolamine Induces High Affinity Binding Sites for Factor VIII on Membranes Containing Phosphatidyl-L-serine (1995)

Synthetic membranes of phosphatidylcholine require inclusion of at least 5% phosphatidylserine (Ptd-L-Ser) to form binding sites for factor VIII. The relatively high requirement for Ptd-L-Ser suggests that stimulated platelets may contain another membrane constituent that enhances expression of factor VIII-binding sites. We report that phosphatidylethanolamine (PE), which is exposed in concert with Ptd-L-Ser in the course of platelet stimulation, induces high affinity binding sites for factor VIII on synthetic membranes containing 1-15% Ptd-L-Ser. The affinity of factor VIII for binding sites on membranes of Ptd-L-Ser/PE/phosphatidylcholine in a 4:20:76 ratio was 10.2 +/- 3.5 nM with 180 +/- 33 phospholipid molecules/site. PE did not induce binding sites on membranes of 4% Ptd-D-Ser, indicating that the induced binding sites require the correct stereochemistry of Ptd-L-Ser as well as PE. Egg PE and dimyristoyl-PE were equivalent for inducing factor VIII-binding sites, indicating that hexagonal phase-inducing properties of PE are not important. We conclude that PE induces high affinity factor VIII-binding sites on membranes with physiologic mole fractions of Ptd-L-Ser, possibly including those of stimulated platelets.
Clusterin Activates Survival through the Phosphatidylinositol 3-Kinase/Akt Pathway (2008)

Clusterin is, in its major form, a secreted heterodimeric disulfide-linked glycoprotein (75-80 kDa). It was first linked to cell death in the rat ventral prostate after androgen deprivation. Recent studies have demonstrated that overexpression of clusterin in prostatic cells protects them against tumor necrosis factor-alpha (TNFalpha)-induced apoptosis. However the details of this survival mechanism remain undefined. Here, we investigate how clusterin prevents cells from undergoing TNFalpha-induced apoptosis. We established a double-stable prostatic cell line for inducible clusterin by using the Tet-On gene expression system. We demonstrated that 50% of the cells overexpressing clusterin escaped from TNFalpha- and actinomycin D-induced cell death. Moreover we demonstrated that the incubation of MLL cells with conditioned medium containing the secreted clusterin or the supplementation of purified clusterin in the extracellular medium decreased the TNFalpha-induced apoptosis significantly. This extracellular action implicates megalin, the putative membrane receptor for clusterin to mediate survival. Indeed clusterin overexpression up-regulated the expression of megalin and induced its phosphorylation in a dose-dependent manner. We interestingly showed that clusterin overexpression is associated with the up-regulation of the phosphorylation of Akt. Activated Akt induced the phosphorylation of Bad and caused a decrease of cytochrome c release. These results enable us to pinpoint one mechanism by which secreted clusterin favors survival in androgen-independent prostate cancer cells, implicating its receptor megalin and Akt survival pathway.
Methicillin-Resistant S. aureus Infections among Patients in the Emergency Department (2006)

MRSA is the most common identifiable cause of skin and soft-tissue infections among patients presenting to emergency departments in 11 U.S. cities. When antimicrobial therapy is indicated for the treatment of skin and soft-tissue infections, clinicians should consider obtaining cultures and modifying empirical therapy to provide MRSA coverage.
Novel Markers of Subclinical Disease for Ewing Family Tumors from Gene Expression Profiling (2007)

This gene expression array-based approach identified novel markers that may be informative at diagnosis for risk group assessment. Their clinical utility needs to be tested in large patient cohorts.
A multi-strain Synbiotic may reduce viral respiratory infections in asthmatic children: a randomized controlled trial (2016)

This research was supported financially by the Research Council of Mashhad University of Medical Sciences (Grant Number: 911048).
Brief vs. Comprehensive Descriptions in Measuring Intentions to Purchase (1971)

This study eximines “An Analysis of Meaning in English Menu as a Strategy in Shaping the Brand Image at TONES No. 6 Café.” It focuses on two aspects: (1) the contribution of English menu naming to brand image formation, and (2) the extent to which consumers understand or misinterpret those menu names. Using a descriptive qualitative method, data were gathered through interviews, observations, and documentation involving three visitors, a barista, and the café’s operational manager. Data validity was ensured through source and technique triangulation. The findings show that English menu naming is intentionally aligned with the café’s vintage music theme, helping to build a modern, international brand image, especially appealing to young urban audiences. This strategy reflects Heller’s (2010) theory of language as a symbolic resource that shapes identity and market value in globalization. The creative English menu names function not only as branding tools but also as triggers of curiosity and interaction, enhancing customer experience. However, some customers face initial confusion due to unfamiliar terms, prompting them to ask staff for clarification. While this fosters social interaction, it also shows the need for clearer descriptions. Overall, the strategy effectively supports branding and creates a distinct identity, but it requires a balance between creativity and accessibility to ensure all visitors can engage with the brand. This research is expected to contribute to a better understanding of how language can influence the business Keywords: English menu naming, brand image, café branding strategy, customer understanding
Hypochlorhydria induced by a proton pump inhibitor leads to intragastric microbial production of acetaldehyde from ethanol (2000)

Treatment with proton pump inhibitors leads to hypochlorhydria, which associates with intragastric overgrowth of aerobic bacteria and microbially-mediated acetaldehyde production from ethanol. Since acetaldehyde is a local carcinogen in the concentrations found in this study, long-term use of gastric acid secretory inhibitors is a potential risk-factor for gastric and cardiac cancers.
Boolean analysis identifies CD38 as a biomarker of aggressive localized prostate cancer (2018)

The introduction of serum Prostate Specific Antigen (PSA) testing nearly 30 years ago has been associated with a significant shift towards localized disease and decreased deaths due to prostate cancer. Recognition that PSA testing has caused over diagnosis and over treatment of prostate cancer has generated considerable controversy over its value, and has spurred efforts to identify prognostic biomarkers to distinguish patients who need treatment from those that can be observed. Recent studies show that cancer is heterogeneous and forms a hierarchy of tumor cell populations. We developed a method of identifying prostate cancer differentiation states related to androgen signaling using Boolean logic. Using gene expression data, we identified two markers, CD38 and ARG2, that group prostate cancer into three differentiation states. Cancers with CD38-, ARG2- expression patterns, corresponding to an undifferentiated state, had significantly lower 10-year recurrence-free survival compared to the most differentiated group (CD38+ARG2+). We carried out immunohistochemical (IHC) staining for these two markers in a single institution (Stanford; <i>n =</i> 234) and multi-institution (Canary; <i>n =</i> 1326) cohorts. IHC staining for CD38 and ARG2 in the Stanford cohort demonstrated that combined expression of CD38 and ARG2 was prognostic. In the Canary cohort, low CD38 protein expression by IHC was significantly associated with recurrence-free survival (RFS), seminal vesicle invasion (SVI), extra-capsular extension (ECE) in univariable analysis. In multivariable analysis, ARG2 and CD38 IHC staining results were not independently associated with RFS, overall survival, or disease-specific survival after adjusting for other factors including SVI, ECE, Gleason score, pre-operative PSA, and surgical margins.
Hyperlipidemia of diuretic therapy. (1998)

Hyperlipidemia is a widely acknowledged side effect of thiazide diuretic therapy, but it is often dismissed as a short-term effect of high-dose therapy. Large clinical trials usually show no lipid change during late follow-up. These large trials use intention-to-treat analysis which masks the lipid effect. On-treatment analysis regularly reveals the persistence of hyperlipidemia during 4-5 years of treatment. Studies of low-dose thiazide therapy give conflicting results. Meta-analysis of these studies reveals hyperlipidemia of a milder degree than with high-dose thiazide treatment. However, a trade-off of effects is apparent because systolic blood pressure is lowered less well with low doses. Thus, thiazide effects on blood pressure and lipids are dose-dependent. Similar meta-analysis of indapamide 2.5 mg daily shows no adverse lipid effect and a lowering of blood pressure equivalent to 50 mg of hydrochlorothiazide. Regarding clinical events, low-dose thiazide treatment exerts primary prevention of coronary heart disease but provides less benefit against stroke and congestive heart failure than does high-dose therapy. Thus, an evidence-based therapeutic strategy for further reducing cardiovascular risk is as follows: initiate antihypertensive therapy with low-dose diuretics. Add beta-blockers and dihydropyridine-type calcium channel blockers for further antihypertensive effect, if needed. Hypertension resistant to a 3-drug regimen should be treated with high-dose thiazides. Lipids should be monitored at each step and treated with diet and statin drugs to maintain lipid goals. Risk factor control is an old concept that has yet to be effectively implemented.
Lead-free organic–inorganic tin halide perovskites for photovoltaic applications (2014)

Perovskite solar cells based on abundant low cost materials promise to compete on performance with mainstream PV. Here we demonstrate lead-free perovskite solar cells, removing a potential barrier to widespread deployment.
N-methylated dioxopiperazines (1972)

A. B. Mauger, R. B. Desai, I. Rittner and W. J. Rzeszotarski, J. Chem. Soc., Perkin Trans. 1, 1972, 2146 DOI: 10.1039/P19720002146
Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers (2011)

PACAP38-induced headache is associated with prolonged dilatation of the MMA but not of the MCA. Sumatriptan relieves headache in parallel with contraction of the MMA but not of the MCA.
Exchange of Aspartate and Alanine (1996)

We examined the idea that aspartate metabolism by Lactobacillus subsp. M3 is organized as a proton-motive metabolic cycle by using reconstitution to monitor the activity of the carrier, termed AspT, expected to carry out the electrogenic exchange of precursor (aspartate) and product (alanine). Membranes of Lactobacillus subsp. M3 were extracted with 1.25% octyl glucoside in the presence of 0. 4% Escherichia coli phospholipid and 20% glycerol. The extracts were then used to prepare proteoliposomes loaded with either aspartate or alanine. Aspartate-loaded proteoliposomes accumulated external [3H]aspartate by exchange with internal substrate; this homologous self-exchange (Kt = 0.4 mm) was insensitive to potassium or proton ionophores and was unaffected by the presence or absence of Na+, K+, or Mg2+. Alanine-loaded proteoliposomes also took up [3H]aspartate in a heterologous antiport reaction that was stimulated or inhibited by an inside-positive or inside-negative membrane potential, respectively. Several lines of evidence suggest that these homologous and heterologous exchange reactions were catalyzed by the same functional unit. Thus, [3H]aspartate taken up by AspT during self-exchange was released by a delayed addition of alanine. In addition, the spontaneous loss of AspT activity that occurs when a detergent extract is held at 37 degrees C prior to reconstitution was prevented by the presence of either aspartate (KD(aspartate) = 0.3 mm) or alanine (KD(alanine) > or = 10 mm), indicating that both substrates interact directly with AspT. These findings are consistent with operation of a proton-motive metabolic cycle during aspartate metabolism by Lactobacillus subsp. M3.
Evaluation of relationship between myocardial contractile state and left ventricular function in patients with aortic regurgitation. (1985)

We studied the relationship between myocardial contractile state and left ventricular functional response to exercise in 14 asymptomatic patients with isolated moderate-to-severe aortic regurgitation and six control subjects. The slope of the systolic blood pressure-left ventricular end-systolic volume (pressure-volume) relationship determined by radionuclide ventriculography during angiotensin infusion was used as an indirect measure of myocardial contractility and was compared with left ventricular ejection fraction at rest and during both isometric handgrip and dynamic bicycle exercise. The slope of the pressure-volume relationship was significantly lower in patients with aortic regurgitation than in the control subjects (1.75 +/- 0.57 vs 2.78 +/- 0.42, p less than 0.01). The slope correlated exponentially with resting ejection fraction and was linearly related to changes in left ventricular ejection fraction during both handgrip and bicycle exercise. In patients with aortic regurgitation, resting ejection fraction may overestimate myocardial function. The slope of the pressure-volume relationship measured during afterload stress and left ventricular ejection fraction response to exercise intervention more reliably reflect the degree of left ventricular dysfunction.
Targeted disruption of p70s6kdefines its role in protein synthesis and rapamycin sensitivity (1998)

Here, we disrupted the p70 S6 kinase (p70(s6k)) gene in murine embryonic stem cells to determine the role of this kinase in cell growth, protein synthesis, and rapamycin sensitivity. p70(s6k-/-) cells proliferated at a slower rate than parental cells, suggesting that p70(s6k) has a positive influence on cell proliferation but is not essential. In addition, rapamycin inhibited proliferation of p70(s6k-/-) cells, indicating that other events inhibited by the drug, independent of p70(s6k), also are important for both cell proliferation and the action of rapamycin. In p70(s6k-/-) cells, which exhibited no ribosomal S6 phosphorylation, translation of mRNA encoding ribosomal proteins was not increased by serum nor specifically inhibited by rapamycin. In contrast, rapamycin inhibited phosphorylation of initiation factor 4E-binding protein 1 (4E-BP1), general mRNA translation, and overall protein synthesis in p70(s6k-/-) cells, indicating that these events proceed independently of p70(s6k) activity. This study localizes the function of p70(s6k) to ribosomal biogenesis by regulating ribosomal protein synthesis at the level of mRNA translation.
MIPS: analysis and annotation of proteins from whole genomes (2003)

The Munich Information Center for Protein Sequences (MIPS-GSF), Neuherberg, Germany, provides protein sequence-related information based on whole-genome analysis. The main focus of the work is directed toward the systematic organization of sequence-related attributes as gathered by a variety of algorithms, primary information from experimental data together with information compiled from the scientific literature. MIPS maintains automatically generated and manually annotated genome-specific databases, develops systematic classification schemes for the functional annotation of protein sequences and provides tools for the comprehensive analysis of protein sequences. This report updates the information on the yeast genome (CYGD), the Neurospora crassa genome (MNCDB), the database of complete cDNAs (German Human Genome Project, NGFN), the database of mammalian protein-protein interactions (MPPI), the database of FASTA homologies (SIMAP), and the interface for the fast retrieval of protein-associated information (QUIPOS). The Arabidopsis thaliana database, the rice database, the plant EST databases (MATDB, MOsDB, SPUTNIK), as well as the databases for the comprehensive set of genomes (PEDANT genomes) are described elsewhere in the 2003 and 2004 NAR database issues, respectively. All databases described, and the detailed descriptions of our projects can be accessed through the MIPS web server (http://mips.gsf.de).
Permeation Through the Cftr Chloride Channel (2000)

The cystic fibrosis transmembrane conductance regulator (CFTR) protein forms a Cl(-) channel found in the plasma membranes of many epithelial cells, including those of the kidney, gut and conducting airways. Mutation of the gene encoding CFTR is the primary defect in cystic fibrosis, a disease that affects approximately 30 000 individuals in the United States alone. Alteration of CFTR function also plays an important role in the pathophysiology of secretory diarrhea and polycystic kidney disease. The basic mechanisms of permeation in this channel are not well understood. It is not known which portions of the protein contribute to forming the pore or which amino acid residues in those domains are involved in the biophysical processes of ion permeation. In this review, I will discuss (i) the present understanding of ion transport processes in the wild-type CFTR channel, (ii) the experimental approaches currently being applied to investigate the pore, and (iii) a proposed structure that takes into account the present data on mechanisms of ion selectivity in the CFTR channel and on blockade of the pore by open-channel blockers.
Grid-search-based hybrid TOA/AOA location techniques for NLOS environments (2009)

For geometrically based single bounce circular model (GBSBCM), a new grid-search based technique is proposed to solve the constraint, nonlinear, underdetermined equations for wireless location in non-lineof- sight (NLOS) environments. Under the assumption of relatively small measurement errors of angle of arrival (AOA) and time of arrival (TOA), more accurate location results than those of existing methods can be achieved by searching in the feasible area.
Determination of earthquake energy release and ML using TERRAscope (1993)

We estimated the energy radiated by earthquakes in southern California using on-scale very broadband recordings from TERRAscope. The method we used involves time integration of the squared ground-motion velocity and empirical determination of the distance attenuation function and the station corrections. The time integral is typically taken over a duration of 2 min after the P-wave arrival. The attenuation curve for the energy integral we obtained is given by q(r) = cr^(−n)exp(−kr)(r^2 = Δ^2 + h_(ref)^2) with c = 0.49710, n = 1.0322, k = 0.0035 km^(−1), and h_(ref) = 8 km, where Δ is the epicentral distance. A similar method was used to determine M_L using TERRAscope data. The station corrections for M_L are determined such that the M_L values determined from TERRAscope agree with those from the traditional optical Wood-Anderson seismographs. For 1.5 6.5, M_L saturates. The ratio E_S/M_0 (M_0: seismic moment), a measure of the average stress drop, for six earthquakes, the 1989 Montebello earthquake (M_L = 4.6), the 1989 Pasadena earthquake (M_L = 4.9), the 1990 Upland earthquake (M_L = 5.2), the 1991 Sierra Madre earthquake (M_L = 5.8), the 1992 Joshua Tree earthquake (M_L = 6.1), and the 1992 Landers earthquake (M_w = 7.3), are about 10 times larger than those of the others that include the aftershocks of the 1987 Whittier Narrows earthquake, the Sierra Madre earthquake, the Joshua Tree earthquake, and the two earthquakes on the San Jacinto fault. The difference in the stress drop between the mainshock and their large aftershocks may be similar to that between earthquakes on a fault with long and short repeat times. The aftershocks, which occurred on the fault plane where the mainshock slippage occurred, had a very short time to heal, hence a low stress drop. The repeat time of the major earthquakes on the frontal fault systems in the Transverse Ranges in southern California is believed to be very long, a few thousand years. Hence, the events in the Transverse Ranges may have higher stress drops than those of the events occurring on faults with shorter repeat times, such as the San Andreas fault and the San Jacinto fault. The observation that very high stress-drop events occur in the Transverse Ranges and the Los Angeles Basin has important implications for the regional seismic potential. The occurrence of these high stress-drop events near the bottom of the seismogenic zone strongly suggests that these fault systems are capable of supporting high stress that will eventually be released in major seismic events. Characterization of earthquakes in terms of the E_S/M_0 ratio using broadband data will help delineate the spatial distribution of seismogenic stresses in the Los Angeles basin and the Transverse Ranges.
Enrichment of sequencing targets from the human genome by solution hybridization (2009)

To exploit fully the potential of current sequencing technologies for population-based studies, one must enrich for loci from the human genome. Here we evaluate the hybridization-based approach by using oligonucleotide capture probes in solution to enrich for approximately 3.9 Mb of sequence target. We demonstrate that the tiling probe frequency is important for generating sequence data with high uniform coverage of targets. We obtained 93% sensitivity to detect SNPs, with a calling accuracy greater than 99%.
Asfotase Alfa Treatment Improves Survival for Perinatal and Infantile Hypophosphatasia (2015)

Asfotase alfa mineralizes the HPP skeleton, including the ribs, and improves respiratory function and survival in life-threatening perinatal and infantile HPP.
Angry Arthur (2003)

Follow Arthur's uncontrollable rage to the bitter end. Children can use this book as a model for their own writing and a way of discussing difficult emotions. By Tara Hart, English co-ordinator at St. John the Divine Primary School, London.
Proposal For An Improvement Of NMR-Imaging By Low-Temperature-squid- Detection Towards Molecular Kinetic Measurements Localized To A Small Sub-Region Of The Sample (1981)

Proposal For An Improvement Of NMR-Imaging By Low-Temperature-squid- Detection Towards Molecular Kinetic Measurements Localized To A Small Sub-Region Of The Sample was published in Biomagnetism on page 535.
Negative Response Elements in Keratin Genes Mediate Transcriptional Repression and the Cross-talk among Nuclear Receptors (2001)

Very little is known about the mechanisms responsible for the findings that binding of nuclear receptors (NR) to some promoter elements leads to transcriptional activation, whereas binding to others leads to repression. Case in point is the group of epidermal keratin genes and their DNA sequences responsible for repression by NR. Keratin response elements (KREs) interact with receptors for retinoic acid, thyroid hormone, and glucocorticoids. KREs, by their structure and sequence, direct the binding of retinoic acid and thyroid hormone as homodimers and glucocorticoids as monomers. Such specific DNA-receptor interactions are crucial for the repression signal of transcription. In this paper we have analyzed the interactions between the KREs and NR that lead to such repression. We have found that KREs are promoter-independent. They not only provide a docking platform for the receptors, but also play a key role in directing the receptors to bind into particular configurations and coordinating the interactions among different receptors. Both an intact KRE and an intact receptor DNA-binding domain are necessary for the regulation to occur, which emphasizes the importance of interaction between the DNA and NR for proper signaling. Furthermore, KREs allow simultaneous binding of multiple receptors, thus providing fine-tuning of transcriptional regulation. The DNA/DNA-binding domain interactions in keratin promoters exemplify tissue and gene specificity of hormone action.