gebhart/patrepeval huggingface dataset:
Virtual Calibration for RSSI-Based Indoor Localization with IEEE 802.15.4 (2009)

Localization systems based on Received Signal Strength Indicator (RSSI) exploit fingerprinting (based on extensive signal strength measurements) to calibrate the system parameters. This procedure is very expensive in terms of time as it relies on human operators. In this paper we propose a virtual calibration procedure which only exploits the measurements of the RSSI between pairs of anchors. In particular, we propose two procedures for virtual calibration and we evaluate their performance with respect to an ad-hoc calibration campaign by performing measures in an indoor environment with an IEEE 802.15.4 sensor network.
[Effects of turtle egg powder mixture on serum lipids of experimental hyperlipidemia rats]. (2004)

Serum TC and TG levels were significantly decreased in the 5.0 g/kg BW group compared with the HF rats (P < 0.05), and at the same time, HDL-C level and its ratio to TC were not affected in groups fed high fat diet.
Sensor Fault Identification Using Autoregressive Models and the Mutual Information Concept (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Purification and properties of a nitrilase specific for the herbicide bromoxynil and corresponding nucleotide sequence analysis of the bxn gene. (1988)

A Klebsiella ozaenae nitrilase which converts the herbicide bromoxynil (3,5-dibromo-4-hydroxybenzonitrile) to 3,5-dibromo-4-hydroxybenzoic acid has been expressed at 5-10% of the total protein in Escherichia coli from a cloned K. ozaenae DNA segment and purified 10.3-fold to homogeneity. The purified polypeptide is molecular weight 37,000 in size, but the active form of the enzyme is composed of two identical subunits. The purified enzyme exhibits a pH optimum of 9.2 and a temperature optimum of 35 degrees C. The purified enzyme is also quite sensitive to thiol-specific reagents. The nitrilase is highly specific for bromoxynil as substrate with a Km of 0.31 mM and Vmax of 15 mumol of NH3 released/min/mg protein. Analysis of bromoxynil-related substrates indicates the enzyme exhibits preference for compounds containing two meta-positioned halogen atoms. Nucleotide sequence analysis of a 1,212-base pair PstI-HincII DNA segment containing the locus (bxn) encoding the bromoxynil-specific nitrilase reveals a single open reading frame encoding a polypeptide 349 amino acids in length. The predicted sequence of the purified enzyme was derived from the nucleotide sequence of the bxn gene.
Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma (2016)

Adoptive cell transfer can mediate durable complete regressions in 24% of patients with metastatic melanoma, with median survival > 3 years. Results were similar using chemotherapy preparative regimens with or without addition of TBI.
Activation of the first component of human complement, C1, by monoclonal antibodies directed against different domains of subcomponent C1q. (1986)

Two monoclonal antibodies directed against C1q, and their (Fab)2 and Fab fragments, were used to study the mechanism of C1 activation. Monoclonal antibody 2A10, an IgG2a, was digested by pepsin to yield fully immunoreactive (Fab')2. Monoclonal antibody 1H11, an IgG1, was digested by papain to yield fully immunoreactive, bivalent (Fab)2. Previously 1H11 had been shown to bind to the C1q "heads," whereas 2A10 bound to stalks. Activation of C1 was followed by the cleavage of 125I-C1s in the presence of C1 inhibitor (C1-Inh) at 37 degrees C. Spontaneous activation was minimal at inhibitor concentrations above 0.4 micron (1.3 X physiologic inhibitor concentration); all results were corrected for the spontaneous activation background. Heat-aggregated IgG activated completely in this system and was taken as 100% activation. Monoclonal antibody 2A10 caused precipitation of C1 and slow activation; neither the (Fab')2 nor the Fab' derived from 2A10-caused activation. Probably, aggregates of intact 2A10 and C1 were serving as immune complexes to activate other molecules of C1. In contrast, both 1H11 and its (Fab)2 activated completely and stoichiometrically; that is, maximal activation was achieved at a ratio of one C1q head to one antibody combining site. The monovalent Fab derived from 1H11 bound well to C1q, but no activation of C1 was observed. Thus, bivalent binding of this head-binding monoclonal is required for C1 activation, but not the presence of the antibody Fc portion. Neither 1H11 nor its (Fab)2 fragments caused C1 precipitation; however, the 1H11 did form complexes composed of two C1q cross-linked by multiple 1H11, which were visualized by electron microscopy. The presence of these dimeric complexes correlated well with activation. A model for C1 activation is proposed in which two C1q subcomponents are held together by multiple (Fab)2 bridging C1q heads. The model is roughly analogous to touching opposing pairs of fingers and thumb tips, the two hands representing the two C1q, forming a cage. C1-Inh, which probably binds to C1r through the open end of the C1 cone, is too long asymmetric to be included within the cage. Thus, according to this model, the dimers of C1 are released from the inhibitory action of C1-Inh, and activation proceeds spontaneously and rapidly at 37 degrees C.
One‐Pot Synthesis of CdTe Nanocrystals and Shape Control of Luminescent CdTe–Cystine Nanocomposites (2006)

Taking shape: Highly fluorescent CdTe nanocrystals were obtained in a one-pot aqueous synthesis with air-stable Na2TeO3 as the Te source. Luminescent 1D nanowires (see confocal image) and 3D microhexagonal columns of CdTe–cystine nanocomposites were also prepared. The composites have the optical properties of the CdTe nanocrystals incorporated in the cystine matrices. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2296/2006/z500346_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Erythropoietin production in human renal carcinoma cells passaged in nude mice and in tissue culture. (1983)

Renal cell carcinoma tissues from two patients, one with and one without erythrocytosis, were successfully transplanted into athymic nude mice. Transplantations of the erythrocytic tumor through six successive generations of nude mice produced a significant (P less than 0.001) elevation in mean hematocrit from 36.5 +/- 2.1% (range 32-42%) to 53.7 +/- 5.1% (range 40-63%), in comparison with a non-erythrocytic tumor which showed a progressive fall in hematocrit from 46.5 +/- 2.0% (range 41-50%) to 36.8 +/- 1.6% (range 33-40%). Non-grafted control nude mice maintained stable hematocrit levels from an initial level of 45 +/- 0.5% to 46.5 +/- 1.2% when studied over the same time interval. Similarly red cell mass values in the mice transplanted with the erythrocytic tumor (5.04 +/- 1.85 ml/100 g) were considerably higher than in both the non-grafted nude mice (3.39 +/- 0.81 ml/100 g) and the non-erythrocytic tumor-grafted mice (3.8 +/- 0.3 ml/100 g) after 6 generations of transplants. Plasma erythropoietin levels in the erythrocytic tumor-grafted mice (169.4 +/- 83.1 mU/ml) were significantly (P less than 0.02) higher than in the non-grafted controls (22.2 +/- 9.5 mU/ml), and furthermore the erythropoietin levels in the tumor extracts were significantly (P less than 0.02) higher in the tumors from erythrocytic mice (range 54.7 to 234.6 mU/g tumor) than in the tumors from non-erythrocytic mice (range 0.3 to 1.9 mU/g tumor). In vitro monolayer cultures of these tumors confirmed the higher erythropoietin levels in the erythrocytic renal carcinoma (138 mU/ml) as compared with culture media of non-erythrocytic tumors (15-91 mU/ml) using the fetal mouse liver assay (59Fe incorp. into heme). The present studies indicate autonomous erythropoietin production by human renal cell carcinomas both in vivo in nude mice and in vitro in tissue cultures.
Mechanism of Radiosensitization by the Chk1/2 Inhibitor AZD7762 Involves Abrogation of the G2 Checkpoint and Inhibition of Homologous Recombinational DNA Repair (2010)

The median survival for patients with locally advanced pancreatic cancer treated with gemcitabine and radiation is approximately 1 year. To develop improved treatment, we have combined a Chk1/2-targeted agent, AZD7762, currently in phase I clinical trials, with gemcitabine and ionizing radiation in preclinical pancreatic tumor models. We found that in vitro AZD7762 alone or in combination with gemcitabine significantly sensitized MiaPaCa-2 cells to radiation. AZD7762 inhibited Chk1 autophosphorylation (S296 Chk1), stabilized Cdc25A, and increased ATR/ATM-mediated Chk1 phosphorylation (S345 Chk1). Radiosensitization by AZD7762 was associated with abrogation of the G(2) checkpoint as well as with inhibition of Rad51 focus formation, inhibition of homologous recombination repair, and persistent gamma-H2AX expression. AZD7762 was also a radiation sensitizer in multiple tumor xenograft models. In both MiaPaCa-2- and patient-derived xenografts, AZD7762 significantly prolonged the median time required for tumor volume doubling in response to gemcitabine and radiation. Together, our findings suggest that G(2) checkpoint abrogation and homologous recombination repair inhibition both contribute to sensitization by Chk1 inhibition. Furthermore, they support the clinical use of AZD7762 in combination with gemcitabine and radiation for patients with locally advanced pancreatic cancer.
Pathway for Polyarginine Entry into Mammalian Cells (2004)

Cationic peptides known as protein transduction domains (PTDs) provide a means to deliver molecules into mammalian cells. Here, nonaarginine (R(9)), the most efficacious of known PTDs, is used to elucidate the pathway for PTD internalization. Although R(9) is found in the cytosol as well as the nucleolus when cells are fixed, this peptide is observed only in the endocytic vesicles of live cells. Colocalization studies with vesicular markers confirm that PTDs are internalized by endocytosis rather than by crossing the plasma membrane. The inability of R(9) to enter living cells deficient in heparan sulfate (HS) suggests that binding to HS is necessary for PTD internalization. This finding is consistent with the high affinity of R(9) for heparin (K(d) = 109 nM). Finally, R(9) is shown to promote the leakage of liposomes but only at high peptide:lipid ratios. These and other data indicate that the PTD-mediated delivery of molecules into live mammalian cells involves (1) binding to cell surface HS, (2) uptake by endocytosis, (3) release upon HS degradation, and (4) leakage from endocytic vesicles.
Los criterios de adjudicación sujetos a juicios de valor: consideraciones prácticas sobre su aplicación y evaluación (2016)

El presente trabajo tiene como principal finalidad poner de manifiesto, por un lado, la relevancia que para la seleccion de la oferta economicamente mas ventajosa, supone la correcta identificacion, ponderacion y evaluacion de los criterios de adjudicacion sujetos a un juicio de valor y, por otro lado, las dificultades de indole practico que supone trasladar esa necesidad a un expediente en concreto al tener que identificar adecuadamente que criterios son los optimos para conseguir nuestros fines publicos y como llevar a cabo la tarea de valoracion de los mismos.
A Potent, Selective Inhibitor of Matrix Metalloproteinase-3 for the Topical Treatment of Chronic Dermal Ulcers (2003)

The pathology of chronic dermal ulcers is characterized by excessive proteolytic activity which degrades extracellular matrix (required for cell migration) and growth factors and their receptors. The overexpression of MMP-3 (stromelysin-1) and MMP-13 (collagenase-3) is associated with nonhealing wounds, whereas active MMPs-1, -2, -9, and -14 are required for normal wound healing to occur. We describe the synthesis and enzyme inhibition profile of (3R)-3-[([(1S)-2,2-dimethyl-1-(([(1S)-2-methoxy-1-phenylethyl]amino)carbonyl)propyl]amino)carbonyl]-6-(3-methyl-4-phenylphenyl)hexanoic acid (UK-370,106, 7), which is a potent inhibitor of MMP-3 (IC(50) = 23 nM) with >1200-fold weaker potency vs MMP-1, -2, -9, and -14. MMP-13, which may also contribute to the pathology of chronic wounds, was inhibited about 100-fold less potently by compound 7. Compound 7 potently inhibited cleavage of [(3)H]-fibronectin by MMP-3 (IC(50) = 320 nM) but not cleavage of [(3)H]-gelatin by either MMP-2 or -9 (up to 100 microM). Compound 7 had little effect, at MMP-3 selective concentrations, on keratinocyte migration over a collagen matrix in vitro, which is a model of the re-epithelialization process. Following iv (rat) or topical administration to dermal wounds (rabbit), compound 7 was cleared rapidly (t(1/2) = 23 min) from plasma, but slowly (t(1/2) approximately 3 days) from dermal tissue. In a model of chronic dermal ulcers, topical administration of compound 7 for 6 days substantially inhibited MMP-3 ex vivo. These data suggest compound 7 is sufficiently potent to inhibit MMP-3-mediated matrix degradation while leaving unaffected cellular migration mediated by MMPs 1, 2, and 9. These properties make compound 7 a suitable candidate for progression to clinical trials in human chronic dermal wounds, such as venous ulcers.
Teicoplanin, antibiotics from Actinoplanes teichomyceticus nov. sp. VII Preparation and NMR characteristics of the aglycone of teicoplanin. (1986)

Several hydrolytic reactions that transform teicoplanin or its pseudo-aglycones into the aglycone with good yields are described. The most interesting approach is hydrolytic removal of the sugars in benzyl alcohol with the formation of the aglycone benzyl ester which is then submitted to hydrogenolysis. A detailed description of the 1H and 13C NMR spectra of the teicoplanin aglycone hydrochloride is presented. All the signals were attributed to the hydrogen and carbon atoms using homo and heteronuclear COSY. The relevant interactions through space between the hydrogen atoms were obtained by NOE. The structural aspects are discussed in terms of the well-known mechanism of action of the glycopeptide antibiotics.
General teleportation channel, singlet fraction, and quasidistillation (1999)

We prove a theorem on direct relation between the optimal fidelity ${f}_{\mathrm{max}}$ of teleportation and the maximal singlet fraction ${F}_{\mathrm{max}}$ attainable by means of trace-preserving local quantum and classical communication (LQCC) action. For a given bipartite state acting on ${C}^{d}\ensuremath{\bigotimes}{C}^{d}$ we have ${f}_{\mathrm{max}}{=(F}_{\mathrm{max}}d+1)/(d+1)$. We assume completely general teleportation scheme (trace preserving LQCC action over the pair and the third particle in unknown state). The proof involves the isomorphism between quantum channels and a class of bipartite states. We also exploit the technique of $U\ensuremath{\bigotimes}{U}^{*}$ twirling states (random application of unitary transformation of the above form) and the introduced analogous twirling of channels. We illustrate the power of the theorem by showing that any bound entangled state does not provide better fidelity of teleportation than for the purely classical channel. Subsequently, we apply our tools to the problem of the so-called conclusive teleportation, then reduced to the question of optimal conclusive increasing of singlet fraction. We provide an example of state for which Alice and Bob have no chance to obtain perfect singlet by LQCC action, but still singlet fraction arbitrarily close to unity can be obtained with nonzero probability. We show that a slight modification of the state has a threshold for singlet fraction, which cannot be exceeded anymore.
Generation of human induced pluripotent stem cells from osteoarthritis patient-derived synovial cells (2011)

Our findings indicate that patient-derived synovial cells are an attractive source of MSCs as well as induced PSCs and have the potential to advance cartilage tissue engineering and cell-based models of cartilage defects.
The influence of VLSI technology evolution on radiation-induced latchup in space systems (1996)

Changes in technology and device scaling have generally increased the sensitivity of VLSI devices to latchup from single interactions of heavy particles in space. This paper discusses latchup mechanisms, comparing latchup from heavy particles in space with electrically induced latchup, which has been more widely studied. The effects of technology changes and device scaling on latchup susceptibility are discussed as well. Test methods and the interpretation of latchup results are also included, along with predictions of the effects of device evolution and scaling on latchup susceptibility in space.
Anticalins as an alternative to antibody technology (2005)

Anticalins are a class of engineered ligand-binding proteins that are based on the lipocalin scaffold. The lipocalin protein architecture is characterised by a compact, rigid beta-barrel that supports four structurally hypervariable loops. These loops form a pocket for the specific complexation of differing target molecules. Natural lipocalins occur in human plasma and body fluids, where they usually function in the transport of vitamins, steroids or metabolic compounds. Using targeted mutagenesis of the loop region and biochemical selection techniques, variants with novel ligand specificities, both for low-molecular weight substances and for macromolecular protein targets, can be generated. Due to their small size, typically between 160 and 180 residues, robust tertiary structure and composition of a single polypeptide chain, such 'anticalins' provide several advantages over antibodies concerning economy of production, stability during storage, faster pharmacokinetics and better tissue penetration. At present, anticalins offer three major mechanisms for therapeutic application: (i) as antidotes, by quickly removing toxic or otherwise irritating compounds from the human body; (ii) as antagonists, for example, by binding to cellular receptors and blocking them from interaction with their natural signalling molecules; (iii) as tissue-targeting vehicles, by addressing toxic molecules or enzymes to disease-related cell surface proteins.
Data Compression for a Source with Markov Characteristics (1987)

The entropy of an information source gives a lower limit to the data compression, measured as the average code/source ratio, which can be achieved without loss of information when transmitting or storing data from that source. The Huffman method for the design of a coding transformation guarantees optimum compression for a finite approximation to the source, i.e. a fixed number of source symbols (or symbol groups) and their respective probabilities. By taking sufficiently large groups, the code/source ratio can de decreased arbitrarily near to the limiting entropy. The method to be presented in this paper takes a contrary approach and guarantees optimum compression for a preselected number of available code symbols (or symbol groups) and takes into account the statistical structure of the source in an optimum way. The use of finite state models provides a formal representation of the resulting encoding transformation, from which encoders and decoders can be designed. The method is further extended to allow for exclusion of source strings with zero probability, but loses the absolute guarantee of optimum data compression for the given number of available code symbols.
A triple-band internal antenna for mobile hand-held terminals (2003)

A novel multi-band internal antenna is introduced. The antenna operates in the AMPS (824-894 MHz), GSM (880-960 MHz), and PCS (1850-1990 MHz) bands within a VSWR of 2.5:1. The size of the antenna is 50 mm by 10 mm by 6 mm. The radiation pattern of the antenna is nearly uniform with some directional properties in the high frequency band.
End-Functionalization of Poly(2,7-fluorene):  A Key Step toward Novel Luminescent Rod−Coil Block Copolymers (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTEnd-Functionalization of Poly(2,7-fluorene): A Key Step toward Novel Luminescent Rod−Coil Block CopolymersD. Marsitzky, M. Klapper, and K. MüllenView Author Information Max-Planck-Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany Cite this: Macromolecules 1999, 32, 25, 8685–8688Publication Date (Web):November 24, 1999Publication History Received22 July 1999Revised1 October 1999Published online24 November 1999Published inissue 1 December 1999https://doi.org/10.1021/ma991216sCopyright © 1999 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1402Altmetric-Citations153LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (92 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Conjugated polymers,Copolymers,Fluorescence,Luminescence,Oxides Get e-Alerts
Symposium:Bovine Immune System (1971)

The objectives of the symposium were threefold: to provide a candid exchange of current information among those studying the bovine immune system; to reach agreement on nomen-
The NAFLD fibrosis score (2007)

a simple scoring system accurately separates patients with NAFLD with and without advanced fibrosis, rendering liver biopsy for identification of advanced fibrosis unnecessary in a substantial proportion of patients.