gebhart/patrepeval huggingface dataset:
Leidenfrost Gas Ratchets Driven by Thermal Creep (2011)

We show that thermal creep is at the origin of the recently discovered Leidenfrost ratchet, where liquid droplets float on a vapor layer along a heated sawtooth surface and accelerate to velocities of up to 40 cm/s. As the active element, the asymmetric temperature profile at each ratchet summit rectifies the vapor flow in the boundary layer. This mechanism works at low Reynolds number and provides a novel tool for controlling gas flow at nanostructured surfaces.
Photoluminescent Metal−Organic Polymer Constructed from Trimetallic Clusters and Mixed Carboxylates (2003)

The solvothermal reaction of zinc acetate dihydrate with a mixture of benzene-1,4-dicarboxylic acid (H(2)BDC) and benzene-1,3,5-tricarboxylic acid (H(3)BTC) in a solution containing N,N'-dimethylformamide (DMF), absolute ethanol, and chlorobenzene gave rise to a metal-organic polymer, Zn(3).BDC.2BTC.2NH(CH(3))(2).2NH(2)(CH(3))(2). The structure of this polymer possesses a unique three-dimensional framework with tri-zinc clusters, and BDC and BTC units colinking the clusters. Moreover, this metal-organic polymer exhibits strong photoluminescence at room temperature, and the main emission band is at about 430 nm (lambda(ex) = 325 nm). Crystal data for this compound (C(17)H(20)N(2)O(8)Zn(1.5)): monoclinic, space group P2(1)/n, cell dimensions a = 11.6171(3) A, b = 14.2456(4) A, c = 12.6426(3) A, beta = 107.030(2) degrees, V = 2000.51(9) A(3), and Z = 4.
Supercritical drying for water-rinsed resist systems (2000)

Two methods of supercritical resist drying (SRD) using CO2 have been developed for water-rinsed resist patterns. The key to their effectiveness is the use of a surfactant. In indirect SRD, a solution of n-hexane, a CO2-philic liquid, and a surfactant, sorbitan fatty acid ether, first replaces the water, and is in turn replaced with liquid CO2 before SRD is performed. The addition of a compound with a high hydrophilic-lipophilic balance to the surfactant compensates for the poor miscibility of water in a solution of n-hexane and sorbitan fatty acid ether. In direct SRD, which does not require a CO2-philic liquid, the water is replaced directly with liquid CO2 containing a surfactant, fluoroether carboxylate, which makes water miscible in CO2; and then SRD is performed. The excellent results obtained by both methods demonstrate that there is no inherent barrier to the use of SRD on water-rinsed resist patterns.
Automated testing of graphics shader compilers (2017)

We present an automated technique for finding defects in compilers for graphics shading languages. key challenge in compiler testing is the lack of an oracle that classifies an output as correct or incorrect; this is particularly pertinent in graphics shader compilers where the output is a rendered image that is typically under-specified. Our method builds on recent successful techniques for compiler validation based on metamorphic testing, and leverages existing high-value graphics shaders to create sets of transformed shaders that should be semantically equivalent. Rendering mismatches are then indicative of shader compilation bugs. Deviant shaders are automatically minimized to identify, in each case, a minimal change to an original high-value shader that induces a shader compiler bug. We have implemented the approach as a tool, GLFuzz, targeting the OpenGL shading language, GLSL. Our experiments over a set of 17 GPU and driver configurations, spanning the main 7 GPU designers, have led to us finding and reporting more than 60 distinct bugs, covering all tested configurations. As well as defective rendering, these issues identify security-critical vulnerabilities that affect WebGL, including a significant remote information leak security bug where a malicious web page can capture the contents of other browser tabs, and a bug whereby visiting a malicious web page can lead to a ``blue screen of death'' under Windows 10. Our findings show that shader compiler defects are prevalent, and that metamorphic testing provides an effective means for detecting them automatically.
Poly(p-phenylene vinylene)/tris(8-hydroxy) quinoline aluminum heterostructure light emitting diode (1995)

Results are presented from polymer/molecular organic heterostructure light emitting diodes composed of a layer of the conjugated conducting polymer poly(p-phenylene vinylene) (PPV), and a layer of fluorescent molecular compound tris(8-hydroxy) quinoline aluminum (Alq). The external quantum efficiency of these heterostructure LEDs is ∼0.1%, which is over one order of magnitude higher than that of simple PPV LEDs. The electroluminescence (EL) spectra indicate that both materials in the device emit comparable amounts of light. The dependence of the EL spectra on the layer thicknesses and its independence on bias suggest that neutral excitons are formed in the Alq, far from the PPV/Alq interface, and subsequently diffuse into the PPV layer.
Influenza vaccination in children with chronic rheumatic diseases and long-term immunosuppressive therapy. (2002)

The results of our study indicate that children with CRD receiving long-term immunosuppressive therapy at conventional doses respond to influenza vaccination similarly to healthy children without serious adverse reactions or disease flares regardless of their age, type of CRD or therapeutic regimen.
A 12.5 GHz-spaced optical frequency comb spanning &gt;400 nm for near-infrared astronomical spectrograph calibration (2010)

A 12.5 GHz-spaced optical frequency comb locked to a global positioning system disciplined oscillator for near-infrared (IR) spectrograph calibration is presented. The comb is generated via filtering a 250 MHz-spaced comb. Subsequent nonlinear broadening of the 12.5 GHz comb extends the wavelength range to cover 1380-1820 nm, providing complete coverage over the H-band transmission window of earth's atmosphere. Finite suppression of spurious sidemodes, optical linewidth, and instability of the comb has been examined to estimate potential wavelength biases in spectrograph calibration. Sidemode suppression varies between 20 and 45 dB, and the optical linewidth is approximately 350 kHz at 1550 nm. The comb frequency uncertainty is bounded by +/-30 kHz (corresponding to a radial velocity of +/-5 cm/s), limited by the global positioning system disciplined oscillator reference. These results indicate that this comb can readily support radial velocity measurements below 1 m/s in the near IR.
Extrapolation in variable RKHSs with application to the blood glucose reading (2011)

In this paper we present a new scheme of a kernel adaptive regularization algorithm, where the kernel and the regularization parameter are adaptively chosen within the regularization procedure. The construction of such a fully adaptive regularization algorithm is motivated by the problem of reading the blood glucose concentration of diabetic patients. We describe how the proposed scheme can be used for this purpose and report the results of numerical experiments with real clinical data.
High mutation frequency in DNA transfected into mammalian cells. (1983)

The lacI gene of Escherichia coli was used to score mutation in mammalian cells of simian virus 40-based recombinant DNA vectors that provide for replication and selection in both bacterial and mammalian cells. Plasmid DNA was introduced into COS7 simian cells by DEAE-dextran transfection, allowed to replicate in the mammalian cells, and then returned to E. coli for analysis. Mutants in lacI were observed at frequencies of one to several percent, compared with a spontaneous mutation rate in E. coli of less than 10(-5). The lesions include a large number of base substitutions, in addition to deletions, duplications, and more complex rearrangements, including insertion into the plasmid of sequences originating in the host genome. We discuss possible sources of the high mutation frequency and its implications for experiments involving DNA transfer.
Sub-operating systems (2002)

Users regularly exchange apparently innocuous data files using email and ftp. While the users view these data as passive, there are situations when they are interpreted as code by some system application. In that case the data become "active". Some examples of such data are Java, JavaScript and Microsoft Word attachments, each of which are executed within the security context of the user, allowing potentially arbitrary machine access. The structure of current operating systems and user applications makes solving this problem challenging.We propose a new protection mechanism to address active content, which applies fine-grained access controls at the level of individual data objects. All data objects arriving from remote sources are tagged with a non-removable identifier. This identifier dictates its permissions and privileges rather than the file owner's user ID. Since users possess many objects, the system provides far more precise access control policies to be enforced, and at a far finer granularity than previous designs.
Mining Web Graphs for Recommendations (2011)

As the exponential explosion of various contents generated on the Web, Recommendation techniques have become increasingly indispensable. Innumerable different kinds of recommendations are made on the Web every day, including movies, music, images, books recommendations, query suggestions, tags recommendations, etc. No matter what types of data sources are used for the recommendations, essentially these data sources can be modeled in the form of various types of graphs. In this paper, aiming at providing a general framework on mining Web graphs for recommendations, (1) we first propose a novel diffusion method which propagates similarities between different nodes and generates recommendations; (2) then we illustrate how to generalize different recommendation problems into our graph diffusion framework. The proposed framework can be utilized in many recommendation tasks on the World Wide Web, including query suggestions, tag recommendations, expert finding, image recommendations, image annotations, etc. The experimental analysis on large data sets shows the promising future of our work.
Patterns of Variant Polyadenylation Signal Usage in Human Genes (2000)

The formation of mature mRNAs in vertebrates involves the cleavage and polyadenylation of the pre-mRNA, 10-30 nt downstream of an AAUAAA or AUUAAA signal sequence. The extensive cDNA data now available shows that these hexamers are not strictly conserved. In order to identify variant polyadenylation signals on a large scale, we compared over 8700 human 3' untranslated sequences to 157,775 polyadenylated expressed sequence tags (ESTs), used as markers of actual mRNA 3' ends. About 5600 EST-supported putative mRNA 3' ends were collected and analyzed for significant hexameric sequences. Known polyadenylation signals were found in only 73% of the 3' fragments. Ten single-base variants of the AAUAAA sequence were identified with a highly significant occurrence rate, potentially representing 14.9% of the actual polyadenylation signals. Of the mRNAs, 28.6% displayed two or more polyadenylation sites. In these mRNAs, the poly(A) sites proximal to the coding sequence tend to use variant signals more often, while the 3'-most site tends to use a canonical signal. The average number of ESTs associated with each signal type suggests that variant signals (including the common AUUAAA) are processed less efficiently than the canonical signal and could therefore be selected for regulatory purposes. However, the position of the site in the untranslated region may also play a role in polyadenylation rate.
Human papillomavirus type 16 nucleoprotein E7 is a tumor rejection antigen. (1991)

It has been speculated that immunological mechanisms play an important role in the control of carcinomas associated with human papillomavirus (HPV), such as cervical cancers. We have now demonstrated that immunization of C3H/HeN mice by syngeneic nontumorigenic fibroblast-like cells that contain the transfected HPV-16 E7 gene conferred protection against transplanted cells from a HPV-16 E7-positive syngeneic tumor. This protection was HPV-16 E7-specific and was mediated by CD8+ lymphocytes, which presumably were cytotoxic T lymphocytes. These results indicate that tumor cells containing HPV-16 E7, either as a result of transfection, as in our studies, or naturally, as occurs in many human carcinomas, can induce a tumor-specific rejection response and serve as targets for such a response. The system described here provides an animal model to further study immune responses to HPV-associated malignancies and to test the efficacy of anti-HPV vaccines toward the therapy and prevention of such tumors.
Lactate and Acrylate Metabolism by Megasphaera elsdenii under Batch and Steady-State Conditions (2012)

The growth of Megasphaera elsdenii on lactate with acrylate and acrylate analogues was studied under batch and steady-state conditions. Under batch conditions, lactate was converted to acetate and propionate, and acrylate was converted into propionate. Acrylate analogues 2-methyl propenoate and 3-butenoate containing a terminal double bond were similarly converted into their respective saturated acids (isobutyrate and butyrate), while crotonate and lactate analogues 3-hydroxybutyrate and (R)-2-hydroxybutyrate were not metabolized. Under carbon-limited steady-state conditions, lactate was converted to acetate and butyrate with no propionate formed. As the acrylate concentration in the feed was increased, butyrate and hydrogen formation decreased and propionate was increasingly generated, while the calculated ATP yield was unchanged. M. elsdenii metabolism differs substantially under batch and steady-state conditions. The results support the conclusion that propionate is not formed during lactate-limited steady-state growth because of the absence of this substrate to drive the formation of lactyl coenzyme A (CoA) via propionyl-CoA transferase. Acrylate and acrylate analogues are reduced under both batch and steady-state growth conditions after first being converted to thioesters via propionyl-CoA transferase. Our findings demonstrate the central role that CoA transferase activity plays in the utilization of acids by M. elsdenii and allows us to propose a modified acrylate pathway for M. elsdenii.
Survive or die? An empirical study on Chinese ST firms (2012)

A number of listed firms that are experiencing financial distress have had a Special Treatment (ST) 'cap' imposed on them by the China Securities Regulatory Commission. The ST 'cap' can be removed if the firms survive financial distress by becoming profitable. Alternatively, a ST firm which goes bankrupt is delisted from the market. Using a sample of 441 ST firms tracked from 1998 to 2011, this paper employs Cox's proportional hazards model to predict turnaround probability for a distressed firm to remove the ST 'cap'. The predictor variables incorporate: (1) accounting-driven ratios, (2) market-driven variables, and (3) information on ownership structure and restructuring status throughout the process. Unlike prior distress studies, accounting variables alone are found to provide the highest prediction accuracy (of 82.2%). Given the uniqueness of the legislations surrounding the suspension and termination of ST firms, this paper adds important new empirical evidence to the current financial distress literature.
Anti-CD81 activates LFA-1 on T cells and promotes T cell-B cell collaboration (2001)

CD81 is expressed on human T cells at all stages of development. CD81 is physically associated with CD4 and CD8 and antibodies against CD81 generate signals which influence thymocyte adhesion and proliferation. Here we evaluate the function of CD81 on mature T cells. We employ a system in which B cells present superantigen to autologous T cells and find that anti-CD81 promotes T cell-B cell collaboration. Anti-CD81 induces T cell-B cell adhesion of peripheral blood lymphocytes which is partially mediated by LFA-1. CD81 engagement promotes LFA-1-dependent T cell activation, IL-2 production and proliferation. The antibody 5A6 was uniquely potent in exerting these effects compared to another antibody to CD81 or to antibodies that react with other tetraspanins expressed on T cells, anti-CD53 or anti-CD82. CD81-derived signals rapidly induce high-avidity LFA-1 as measured by cell binding to recombinant ICAM-3-coated fluorescent microspheres or by cell adhesion to ICAM-3-coated plastic. 5A6 activation of LFA-1 does not expose the high-affinity conformation epitope recognized by monoclonal antibody 24.
Swine Models of Type 2 Diabetes Mellitus: Insulin Resistance, Glucose Tolerance, and Cardiovascular Complications (2006)

In humans, diabetes mellitus (DM) is considered a heterogeneous metabolic disorder. Swine have been used as a model for many human conditions including type 1 (insulin-deficient) and type 2 (insulin-resistant) DM research because of their phenotypic similarities to humans including: cardiovascular anatomy and function, metabolism, lipoprotein profile, size, tendency to obesity, and omnivorous habits. There is phenotypic overlap between the two types of DM and pig models show characteristics and complications of both. Streptozotocin and alloxan have been used to create insulin deficient diabetes in pigs. One of the most unique and useful phenotypes is that these insulin-deficient pigs develop more severe coronary atherosclerosis than nondiabetic controls. It is not fully understood why patients with either type 1 or type 2 DM have increased severity and diffuseness of atherosclerosis compared with nondiabetic patients. The current human epidemic of type 2 DM and its attendant cardiovascular complications underscore the unmet need for creating a useful, readily available animal model of type 2 insulin resistant DM that also develops coronary artery atherosclerosis. The phenotypic susceptibility to coronary atherosclerosis makes pigs an attractive species to identify causative mechanisms. Suggested criteria for validation of an animal model of humanoid type 2 DM are described. The goal would be to develop a useful animal model for mechanistic studies as well as to develop and test novel therapeutics both for type 2 DM as well as its cardiovascular complications.
In Vivo Imaging Shows Abnormal Function of Vascular Endothelial Growth Factor-Induced Vasculature (2007)

Although the angiogenic effect of vascular endothelial growth factor (VEGF) is widely recognized, a central question concerns whether the vessels formed on its overexpression effectively increase tissue perfusion in vivo. To explore this issue, here we exploit AAV vectors to obtain the prolonged expression of VEGF and angiopoietin-1 (Ang1) in rat skeletal muscle. Over a period of 6 months, muscle blood flow (MBF) and vascular permeability were measured by positron emission tomography and single-photon emission computed tomography, respectively. All measurements were performed under resting conditions and after electrically induced muscle exercise. Despite the potent angiogenic effect of VEGF, documented by vessel counting and intravascular volume assessment, the expression of this factor did not improve resting MBF, and it even decreased perfusion after exercise. This deleterious effect was related to the formation of leaky vascular lacunae, which accounted for the occurrence of arteriovenous shunts that excluded the downstream microcirculation. These effects were significantly counteracted by the coinjection of VEGF and Ang1, which determined a marked increase in resting MBF and, most notably, a significant improvement after exercise that persisted over time. Taken together, these results challenge the effectiveness of VEGF as a sole factor to induce angiogenesis and suggest the use of factor combinations to achieve competent vessel formation.
A VISION OF HELL (1986)

MIDAIR COLLISION OF AEROMEXICO FLIGHT 498 AND PRIVATE PLANE OVER CERRITOS, CALIF., AUG. 31, 1986
Immobilised cells and enzymes : a practical approach (1985)

Abbreviations Immobilised enzymes: absorption and covalent coupling Immobilisation of biocatalysts by metal link/chelation processes Immobilisation of cells and enzymes by gel entrapment Immobilisation of enzymes by microencapsulation Immobilised enzyme electrodes Electrochemical techniques with immobilised biological materials Immobilised cells: transformation of steroids Immobilised plant cells: preparation and biosynthetic capacity Immobilised mammalian cells in hormone detection and quantitation Index
The nature and action of granulocyte-macrophage colony stimulating factors (1980)

Granulocyte-macrophage colony stimulating factor (GM-CSF) stimulates the in vitro proliferation and differentiation of granulocytic and macrophage cells. This regulator is now known to act at other levels of hemopoietic regulation. The heterogeneity of GM-CSFs is not only related to the tissue of origin and the in vitro production method, but also to functional subclasses of the molecule that have distinct biologic specificities. Most adult mouse organs produce GM-CSF (mol wt 23,000), but a macrophage (M)-CSF has been detected in fetal conditioned medium (CM) and isolated from L-cell CM. Murine endotoxin serum appears to contain a M-CSF, GM-CSF, and G-CSF, the last of which cofractionates with a differentiation factor active on leukemic cells. Human GM-CSFs, G-CSF, and EO-CSFs active on human cells have been detected in a variety of CM, but as yet none have been purified. Again, there are subclasses of progenitor cells that respond to particular forms of human active CSFs. GM-CSF isolated from mouse lung CM stimulates multipotential progenitor cells, the initial proliferatin of progenitors in the erythroid, eosinophil, and megakaryocyte series, as well as mature cells in the GM series. While GM-CSF is also able to stimulate the differentiation of myeloid leukemic cells, other factors appear to be more potent in this respect. Information on the regulation of GM-CSF production, on the modulators of its action on specific target cells, and on its role in vivo will be required before the physiologic function of this molecule can be properly assessed.
Atherogenic concentrations of native low‐density lipoproteins down‐regulate nitric‐oxide‐synthase mRNA and protein levels in endothelial cells (1998)

The nitric oxide synthase family of proteins is the unique class of mammalian enzymes that metabolizes L-arginine to form nitric oxide (NO). The atherogenic action of low-density lipoproteins (LDL) may be mediated, in part, by its effects on endothelial-derived nitric oxide. To determine whether native LDL (nLDL), at atherogenic concentrations, are capable of modulating NO synthase expression, we treated human umbilical vein endothelial cells with increasing concentrations of human nLDL (0-240 mg cholesterol/dl) for various time periods (2-48 h). Northern and western blot analyses indicate that both endothelial NO-synthase mRNA and protein are down-regulated by atherogenic concentrations of nLDL (180 and 240 mg cholesterol/dl) after 48 h of incubation. Cycloheximide and actinomycin D experiments suggest that this down-regulation operates at a transcriptional level. Additionally, treatment of the cells with high-density lipoproteins, at human physiological concentrations (45 mg cholesterol/dl), does not appear to alter the expression of endothelial NO synthase which seems to indicate that nLDL affect the gene transcription rate by a specific and concentration-dependent mechanism. These findings may have important implications because they provide a novel mechanism by which hypercholesterolemia induces early changes on endothelial cells that could have pathophysiological significance in the atherosclerotic process.