gebhart/patrepeval huggingface dataset:
iMobile: An Agent-Based Platform for Mobile Services. (2001)

iMobile is a platform that addresses the research issues in building mobile services. iMobile acts as a message gateway that allows mobile devices using various protocols on different access networks to relay messages to each other. It also allows these thin clients to access resources and information on the internet and various networks. iMobile implements three key abstractions: devlet, infolet, and applet. A devlet is a driver attached to iMobile that receives and sends messages through a particular protocol for mobile devices. An infolet hosted on iMobile uses a particular access method to provide an abstract view of an information space. An applet implements service or application logic by processing information from various infolets. The foundation of iMobile, the let engine, implements the basic framework for maintaining applets, devlets and infolets, supports user and device profiles for personalization and transcoding, and invokes proper applets and infolets to answer requests from a devlet. The iMobile architecture allows new access devices and protocols to be added to its framework without changes in the service logic. iMobile effectively provides a personal agent on the network that enables a user to have mobile access to the information and services available, without being limited by where the user is or whatever communication or device protocol is available.
Induction of Human Papillomavirus-Specific CD4+and CD8+Lymphocytes by E7-Pulsed Autologous Dendritic Cells in Patients with Human Papillomavirus Type 16- and 18-Positive Cervical Cancer (1999)

Human papillomavirus (HPV) type 16 (HPV 16) and HPV type 18 (HPV 18) are implicated in the induction and progression of the majority of cervical cancers. Since the E6 and E7 oncoproteins of these viruses are expressed in these lesions, such proteins might be potential tumor-specific targets for immunotherapy. In this report, we demonstrate that recombinant, full-length E7-pulsed autologous dendritic cells (DC) can elicit a specific CD8(+) cytotoxic T-lymphocyte (CTL) response against autologous tumor target cells in three patients with HPV 16- or HPV 18-positive cervical cancer. E7-specific CTL populations expressed strong cytolytic activity against autologous tumor cells, did not lyse autologous concanavalin A-treated lymphoblasts or autologous Epstein-Barr virus-transformed lymphoblastoid cell lines (LCL), and showed low levels of cytotoxicity against natural killer cell-sensitive K562 cells. Cytotoxicity against autologous tumor cells could be significantly blocked by anti-HLA class I (W6/32) and anti-CD11a/LFA-1 antibodies. Phenotypically, all CTL populations were CD3(+)/CD8(+), with variable levels of CD56 expression. CTL induced by E7-pulsed DC were also highly cytotoxic against an allogeneic HLA-A2(+) HPV 16-positive matched cell line (CaSki). In addition, we show that specific lymphoproliferative responses by autologous CD4(+) T cells can also be induced by E7-pulsed autologus DC. E7-specific CD4(+) T cells proliferated in response to E7-pulsed LCL but not unpulsed LCL, and this response could be blocked by anti-HLA class II antibody. Finally, with two-color flow cytometric analysis of intracellular cytokine expression at the single-cell level, a marked Th1-like bias (as determined by the frequency of gamma interferon- and interleukin 4-expressing cells) was observable for both CD8(+) and CD4(+) E7-specific lymphocyte populations. Taken together, these data demonstrate that full-length E7-pulsed DC can induce both E7-specific CD4(+) T-cell proliferative responses and strong CD8(+) CTL responses capable of lysing autologous naturally HPV-infected cancer cells in patients with cervical cancer. These results may have important implications for the treatment of cervical cancer patients with active or adoptive immunotherapy.
Closed loop task space control of an interleaved continuum-rigid manipulator (2015)

A new manipulation approach, referred to as interleaved continuum-rigid manipulation, which combines inherently safe, flexible actuated segments with more precise embedded rigid-link joints has recently been introduced [1], [2]. The redundantly actuated manipulator possesses the safety characteristics inherent in flexible segment devices while gaining some of the performance attributes of rigid-link joint systems. In this paper, we describe a general controller developed for an interleaved manipulator. The controller is implemented on a clinically-relevant prototype, the results of which demonstrate the advantages of an interleaved manipulator. We also consider kinematic drivers of the interleaved manipulator workspace, showing that careful kinematic considerations can substantially improve manipulator workspace and task accuracy.
Hydroxyl Radical-Mediated Modification of Proteins as Probes for Structural Proteomics (2007)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydroxyl Radical-Mediated Modification of Proteins as Probes for Structural ProteomicsGuozhong Xu and Mark R. ChanceView Author Information Center for Proteomics, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106 Cite this: Chem. Rev. 2007, 107, 8, 3514–3543Publication Date (Web):August 8, 2007Publication History Received15 February 2007Published online8 August 2007Published inissue 1 August 2007https://pubs.acs.org/doi/10.1021/cr0682047https://doi.org/10.1021/cr0682047research-articleACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views7435Altmetric-Citations567LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Crystal cleavage,Hydroxyls,Monomers,Oxidation,Peptides and proteins Get e-Alerts
Single-Molecule LATE-PCR Analysis of Human Mitochondrial Genomic Sequence Variations (2009)

It is thought that changes in mitochondrial DNA are associated with many degenerative diseases, including Alzheimer's and diabetes. Much of the evidence, however, depends on correlating disease states with changing levels of heteroplasmy within populations of mitochondrial genomes, rather than individual mitochondrial genomes. Thus these measurements are likely to either overestimate the extent of heteroplasmy due to technical artifacts, or underestimate the actual level of heteroplasmy because only the most abundant changes are observable. In contrast, Single Molecule (SM) LATE-PCR analysis achieves efficient amplification of single-stranded amplicons from single target molecules. The product molecules, in turn, can be accurately sequenced using a convenient Dilute-'N'-Go protocol, as shown here. Using these novel technologies we have rigorously analyzed levels of mitochondrial genome heteroplasmy found in single hair shafts of healthy adult individuals. Two of the single molecule sequences (7% of the samples) were found to contain mutations. Most of the mtDNA sequence changes, however, were due to the presence of laboratory contaminants. Amplification and sequencing errors did not result in mis-identification of mutations. We conclude that SM-LATE-PCR in combination with Dilute-'N'-Go Sequencing are convenient technologies for detecting infrequent mutations in mitochondrial genomes, provided great care is taken to control and document contamination. We plan to use these technologies in the future to look for age, drug, and disease related mitochondrial genome changes in model systems and clinical samples.
Challenges for protein chemical synthesis in the 21st century: Bridging genomics and proteomics (2000)

The Human Genome Project and other major sequencing projects have rapidly provided a vast array of new protein sequences. In the postgenomic era, the physical form of many of these gene-encoded sequences will be vital for biomedical research and drug development. In this epoch, the advantages of protein chemical synthesis will complement recombinant-DNA methods, and will be used to provide rapid access to small proteins or functional receptor domains. In this review the key methodological advances that have made the synthesis of long peptides and small proteins more effective will be presented. Focus is given to the issues and goals of contemporary chemical protein synthesis, including (1) the rapid chain assembly of tailored peptide segments for use in ligation strategies, and (2) development of highly efficient and universal chemoselective ligation strategies. Biopolymers (Pept Sci) 55: 217-226, 2000
ON THE BEHAVIOR OF A CAPILLARY SURFACE IN A WEDGE (1969)

Estimates above and below are obtained for the height of the equilibrium-free surface of a liquid when the liquid partially fills a cylindrical container whose cross section contains a corner with interior angle 2alpha. The surface is characterized by the condition that its mean curvature be proportional to its height above a reference plane (or, in the case of zero gravity, that the mean curvature be constant), and by the requirement that it meet the container wall with prescribed contact angle gamma. It turns out that the qualitative behavior of such a surface near the vertex changes markedly, according as alpha + gamma < (1/2)pi, or alpha + gamma >/= (1/2)pi. In the former case, the surface is either unbounded or fails to exist, while in the latter case every such surface is bounded. Some experimental comparisons are indicated, and an application to the problem of describing the mechanism of water rise in trees is discussed.The above results describe a limiting case among corresponding properties that hold for surfaces defined over domains with smooth boundaries. This extension is indicated, as well as a formal extension to n-dimensional surfaces; here the interest centers on the fact that it is the mean curvature of an (n-1)-dimensional boundary element that controls the local behavior of the n-dimensional solution surface.
[Immunotherapy of metastatic renal cell carcinoma: report of 28 cases]. (2004)

The three-drugs combination described in this study demonstrates activity. Based on the present data, combined biochemotherapy may be a promising new approach to the therapy of the metastatic renal cell carcinoma.
Tumor cell expression of programmed cell death‐1 ligand 1 is a prognostic factor for malignant melanoma (2010)

: The current results indicated that there is a correlation between the degree of PD-L1 expression and the vertical growth of primary tumors in melanoma. Multivariate analysis demonstrated that PD-L1 expression is an independent prognostic factor for melanoma. Cancer 2010. (c) 2010 American Cancer Society.
Benign adrenocortical masses: diagnosis with chemical shift MR imaging. (1992)

Benign adrenocortical masses often contain lipid; metastases and pheochromocytomas do not. Standard and lipid-sensitive (chemical shift) magnetic resonance (MR) images of the adrenal glands in 31 patients with 45 adrenal masses were reviewed to determine if simple visual analysis of these images would increase diagnostic specificity. Lipid was considered present if signal intensity of the adrenal mass relative to other tissues decreased on chemical shift images relative to comparable standard images. Both myelolipomas and 26 of 27 benign cortical masses displayed a loss of signal intensity on at least one chemical shift image; all 12 metastases, the three hemorrhages, and a cyst did not. Opposed-phase images were slightly more sensitive than fat-suppressed images in depicting lipid within benign cortical masses. All masses had higher signal intensity than that of the liver on standard T2-weighted MR images. Chemical shift MR imaging can demonstrate lipid within benign adrenocortical masses and thus increase specificity, potentially obviating biopsy and aggressive follow-up.
Sliding Block Decoding of Convolutional Codes (1981)

It is shown that a convolutional code can be decoded with a sliding-block decoder, a time-invariant nonlinear digital filter with finite memory and delay. If the memory and delay are small, then the sliding-block decoder can be implemented as a table lookup procedure in ROM, resulting in a low cost, high speed, and high reliability decoder.
Oligonucleotide Probes That Detect Quantitatively Significant Groups of Butyrate-Producing Bacteria in Human Feces (2003)

16S rRNA-targeted oligonucleotide probes were designed for butyrate-producing bacteria from human feces. Three new cluster-specific probes detected bacteria related to Roseburia intestinalis, Faecalibacterium prausnitzii, and Eubacterium hallii at mean populations of 2.3, 3.8, and 0.6%, respectively, in samples from 10 individuals. Additional species-level probes accounted for no more than 1%, with a mean of 7.7%, of the total human fecal microbiota identified as butyrate producers in this study. Bacteria related to E. hallii and the genera Roseburia and Faecalibacterium are therefore among the most abundant known butyrate-producing bacteria in human feces.
Oxidation and reduction of hemoproteins by trioxodinitrate(II). The role of nitrosyl hydride and nitrite (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation and reduction of hemoproteins by trioxodinitrate(II). The role of nitrosyl hydride and nitriteMichael P. Doyle, Surendra N. Mahapatro, Richard D. Broene, and Judith K. GuyCite this: J. Am. Chem. Soc. 1988, 110, 2, 593–599Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/ja00210a047https://doi.org/10.1021/ja00210a047research-articleACS PublicationsRequest reuse permissionsArticle Views568Altmetric-Citations186LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparison of the activities of variant forms of eIF-4D. The requirement for hypusine or deoxyhypusine (1991)

Eukaryotic protein synthesis initiation factor 4D (eIF-4D) (current nomenclature, eIF-5A) contains the unique amino acid hypusine (N epsilon-(4-amino-2-hydroxybutyl)lysine). The first step in hypusine biosynthesis, i.e. the formation of the intermediate, deoxyhypusine (N epsilon-(4-aminobutyl)lysine), was carried out in vitro using spermidine, deoxyhypusine synthase, and ec-eIF-4D(Lys), an eIF-4D precursor prepared by over-expression of human eIF-4D cDNA in Escherichia coli. In a parallel reaction, using N-(3-aminopropyl)cadaverine in place of spermidine, a variant form of eIF-4D containing homodeoxyhypusine (N epsilon-(5-aminopentyl)lysine) was prepared. Evidence that N-(3-aminopropyl)cadaverine can also act as the amine substrate for deoxyhypusine synthase in intact cells was obtained by incubating putrescine- and spermidine-depleted Chinese hamster ovary cells with [3H]cadaverine. In these cells, in which [3H]cadaverine is readily converted to N-(3-aminopropyl) [3H]cadaverine, small amounts of [3H]homodeoxyhypusine and another 3H-labeled compound, presumed to be N epsilon-(5-amino-2-hydroxy[3H]pentyl)lysine, were found. eIF-4D stimulates methionyl-puromycin synthesis, an in vitro model assay for translation initiation. Whereas the unmodified precursor ec-eIF-4D(Lys) appeared inactive, the deoxyhypusine-containing form provided a significant degree of stimulation. The variant form containing homodeoxyhypusine, on the other hand, showed little or no activity. These findings emphasize the importance of hypusine or deoxyhypusine for the biological activity of eIF-4D and demonstrate the influence of both the length and chemical nature of its amino alkyl side chain.
Chemical nucleases (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical nucleasesDavid S. Sigman, Abhijit Mazumder, and David M. PerrinCite this: Chem. Rev. 1993, 93, 6, 2295–2316Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/cr00022a011https://doi.org/10.1021/cr00022a011research-articleACS PublicationsRequest reuse permissionsArticle Views2512Altmetric-Citations875LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Haemodynamics in microvascular complications in type 1 diabetes (2002)

Type 1 diabetes is commonly associated with microvascular complications. Most of the microvascular blood vessels are involved but those in the kidney, retina and large nerves exhibit the more significant pathology. Haemodynamic and metabolic factors both alone and through the activation of a common pathway contribute to the characteristic dysfunction observed in diabetic vasculopathy. The haemodynamic abnormalities in type 1 diabetes are characterized by increased systemic blood pressure and altered blood flow with subsequent activation of various vasoactive factors, which can contribute to the maintenance of the haemodynamic alterations and to the development and progression of the microvascular complications. These vasoactive factors include vasoconstrictors such as angiotensin II, and endothelin, as well as vasodilators such as nitric oxide (NO). Systemic hypertension and vasoactive factors independently and in interaction with the metabolic pathway activate intracellular second messengers, nuclear transcription factors and various growth factors which lead to the typical functional and structural alterations of diabetic microvascular complications. Therapeutic strategies involved in the management and prevention of diabetic complications currently include antihypertensive agents, particularly those that interrupt the renin-angiotensin system. Further understanding of the interactions among the vasoactive factors, the intracellular second messengers and the growth factors may help to identify novel strategies to influence the action of the vasoactive factors. These novel therapies, together with specific inhibitors of the metabolic pathway or the common pathway, may provide the possibility of preventing or even reversing the progression of diabetic microvascular complications.
A calibration-free gaze tracking technique (2002)

We propose a novel method to estimate and track the 3D line of sight of a person based on 3D computer vision techniques. Most of the existing nonintrusive gaze tracking methods share a common drawback that users have to perform certain experiments in calibrating the user-dependent parameters before using the gaze tracking systems. These parameters are functions of the radius of the cornea, the position of the pupil, the position of user's head, etc. Our approach, in contrast, employs multiple cameras and multiple point light sources to estimate the light of sight without using any of the user-dependent parameters. As a consequence, the users can avoid the inconvenient calibration process which may produce possible calibration errors. Computer simulations were performed to confirm the proposed method.
Effect of Carrier Protein Priming on Antibody Responses to Haemophilus influenzae Type b Conjugate Vaccines in Infants (1994)

Vaccination with DT at 1 month of age increases the magnitude of the anti-PRP antibody responses to conjugate vaccination. With HbOC, the effect of carrier priming was present for up to 6 months of age, whereas in infants vaccinated with PRP-T, enhanced immunity was present for at least 12 months.
Development of Frameless Slice image Overlay system for Surgery (2006)

Medical information including medical images are used for surgical navigation system, however, surgeon often encounter the difficulties to obtain a precise registration between pre-operative information and the patient. In this paper, we propose to apply “augmented reality system” with a simple display device. It's comprised of a 5.6inch LCD, a half mirror, and a frameless positioning maker system. Through the half mirror, surgeon can observe the real patient and reflected image of the LCD, on which the navigation image are shown simultaneously at the right position floating inside the patient body to perform minimally invasive surgery. System precision including human perception error are evaluated using phantom experiments and the total result are 1.96±1.28mm and the pilot trial in the operating room are performed toward clinical use.
Mouse Genome Informatics: Mapping/Homology Data (2002)

This article has no abstract.