gebhart/patrepeval huggingface dataset:
Quasi-Recurrent Neural Networks (2016)

Recurrent neural networks are a powerful tool for modeling sequential data, but the dependence of each timestep's computation on the previous timestep's output limits parallelism and makes RNNs unwieldy for very long sequences. We introduce quasi-recurrent neural networks (QRNNs), an approach to neural sequence modeling that alternates convolutional layers, which apply in parallel across timesteps, and a minimalist recurrent pooling function that applies in parallel across channels. Despite lacking trainable recurrent layers, stacked QRNNs have better predictive accuracy than stacked LSTMs of the same hidden size. Due to their increased parallelism, they are up to 16 times faster at train and test time. Experiments on language modeling, sentiment classification, and character-level neural machine translation demonstrate these advantages and underline the viability of QRNNs as a basic building block for a variety of sequence tasks.
Membrane Accumulation of Influenza A Virus Hemagglutinin Triggers Nuclear Export of the Viral Genome via Protein Kinase Cα-mediated Activation of ERK Signaling (2006)

Replication and transcription of the influenza virus genome takes place exclusively within the nucleus of the infected cells. The viral RNA genome, polymerase subunits, and nucleoprotein form ribonucleoprotein (RNP) complexes. Late in the infectious cycle RNPs have to be exported from the nucleus to be enwrapped into budding progeny virions at the cell membrane. This process requires viral activation of the cellular Raf/MEK/ERK (mitogen-activated protein kinase (MAPK)) signaling cascade that is activated late in the infection cycle. Accordingly, block of the cascade results in retardation of RNP export and reduced titers of progeny virus. In the present study we have analyzed the importance of cell-membrane association of the viral hemagglutinin glycoprotein for viral MAPK activation. We show that hemagglutinin membrane accumulation and its tight association with lipid-raft domains trigger activation of the MAPK cascade via protein kinase Calpha activation and induces RNP export. This may represent an auto-regulative mechanism that coordinates timing of RNP export to a point when all viral components are ready for virus budding.
Comparative chracterization of Staphylococcus aureus isolates from throats and noses of healthy volunteers. (2004)

Staphylococcus aureus isolates in 2001 from the nose and the throat of an adult population were characterized for their incidence and type. The incidence was 51%, present in 80 out of 157 individuals examined, consisting of 34 nasal carriers, 24 throat carriers, and 22 who carried the isolates in both the nose and throat. Among these isolates, 2 and 5 from the nose and the throat, respectively, were identified as methicillin-resistant S. aureus. S. aureus from the nose and throat of the same individuals were characterized for identification. Examination of their phenotypes revealed that in 11 individuals the clone of S. aureus in the throat was different from the nasal clone. These results suggested that staphylococcal flora in the nose and the throat were independently formed, and that attention should also be directed to the carriers of S. aureus in the throat for the control of nosocomial infection.
Experimental realization of any discrete unitary operator (1994)

An algorithmic proof that any discrete finite-dimensional unitary operator can be constructed in the laboratory using optical devices is given. Our recursive algorithm factorizes any N\ifmmode\times\else\texttimes\fi{}N unitary matrix into a sequence of two-dimensional beam splitter transformations. The experiment is built from the corresponding devices. This also permits the measurement of the observable corresponding to any discrete Hermitian matrix. Thus optical experiments with any type of radiation (photons, atoms, etc.) exploring higher-dimensional discrete quantum systems become feasible.
Interleukin‐1 in multiple myeloma: producer cells and their role in the control of IL‐6 production (1998)

We studied the role of interleukin (IL)-1beta in patients with multiple myeloma. By in situ hybridization and immunochemistry, myeloid and megakaryocytic cells expressed high levels of the IL-1beta gene and produced IL-1beta. Myeloma cells less potently expressed the IL-1beta gene and IL-1beta protein. IL-1beta gene expression was not constitutive since it was detected in the bone marrow myeloma cells of two patients, unlike circulating tumoural cells. In addition, nine myeloma cell lines failed to express the IL-1beta gene and this expression could not be induced by 12 different cytokines. We demonstrated that IL-1 was mainly responsible for IL-6 production in the tumoural environment through a PGE2 loop. In fact, an IL-1 receptor antagonist (IL-1RA) blocked PGE2 synthesis and IL-6 production by 80%; this blockage could be reversed by adding synthetic PGE2. Similar findings were found with indomethacin, an inhibitor of cyclooxygenase that blocks PGE2 synthesis. Taken together, these data emphasize the possibility of blocking IL-1 by using IL-1RA or other antagonists in order to block IL-6 production, which is a major tumoural survival and proliferation factor.
Cognitive Effects of Pharmacotherapy for Major Depressive Disorder (2014)

Pharmacotherapy may have benefit in reducing cognitive impairment in MDD, with augmentation therapy being a potential approach for addressing cognitive deficits that persist after monotherapy has brought about clinical response or remission. However, given the wide variability in study design and treatment duration across studies, these findings should be interpreted cautiously. More definitive research is required before firm conclusions can be reached.
Progesterone Analogs Influence Germination of Clostridium sordellii and Clostridium difficile Spores In Vitro (2011)

Clostridium sordellii and Clostridium difficile are closely related anaerobic Gram-positive, spore-forming human pathogens. C. sordellii and C. difficile form spores that are believed to be the infectious form of these bacteria. These spores return to toxin-producing vegetative cells upon binding to small molecule germinants. The endogenous compounds that regulate clostridial spore germination are not fully understood. While C. sordellii spores require three structurally distinct amino acids to germinate, the occurrence of postpregnancy C. sordellii infections suggests that steroidal sex hormones might regulate its capacity to germinate. On the other hand, C. difficile spores require taurocholate (a bile salt) and glycine (an amino acid) to germinate. Bile salts and steroid hormones are biosynthesized from cholesterol, suggesting that the common sterane structure can affect the germination of both C. sordellii and C. difficile spores. Therefore, we tested the effect of sterane compounds on C. sordellii and C. difficile spore germination. Our results show that both steroid hormones and bile salts are able to increase C. sordellii spore germination rates. In contrast, a subset of steroid hormones acted as competitive inhibitors of C. difficile spore germination. Thus, even though C. sordellii and C. difficile are phylogenetically related, the two species' spores respond differently to steroidal compounds.
Liability for defective electronic information (1993)

article Free AccessLiability for defective electronic information Author: Pamela Samuelson View Profile Authors Info & Claims Communications of the ACMVolume 36Issue 1Jan. 1993 pp 21–26https://doi.org/10.1145/151233.151234Published:01 January 1993Publication History 13citation494DownloadsMetricsTotal Citations13Total Downloads494Last 12 Months31Last 6 weeks7 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
HPV DNA Testing of Self-collected Vaginal Samples Compared With Cytologic Screening to Detect Cervical Cancer (2000)

These results indicate that HPV testing of self-collected vaginal swabs is less specific than but as sensitive as Papanicolaou smears for detecting high-grade cervical disease in women aged 35 years and older, and HPV testing offers an important new way to increase screening in settings where cytology is not readily performed.
Optoelectronic system integration on silicon: waveguides, photodetectors, and VLSI CMOS circuits on one chip (1995)

Optical waveguides, photodetectors, and VLSI CMOS circuits are integrated monolithically in different ways: in a combined integration technique the light-guiding film is deposited and covered with a SiO/sub 2/ layer replacing standard PSG as the dielectric insulation of polysilicon and metallization. In a stacked method the waveguide fabrication starts after metallization and test of the CMOS circuits. Electrooptical coupling is performed by butt-, leaky wave-, or, mirror-coupling of waveguides and photodetectors. To fabricate the system, SWAMI LOCOS technique is applied for monolithic integration of both, integrated optical devices, and microelectronic circuits. This paper discusses the integration technology and the results of static and dynamic measurements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Zn2+-stimulated Sphingomyelinase Is Secreted by Many Cell Types and Is a Product of the Acid Sphingomyelinase Gene (1996)

Mammalian sphingomyelinases have been implicated in many important physiological and pathophysiological processes. Although several mammalian sphingomyelinases have been identified and studied, one of these, an acidic Zn2+-stimulated sphingomyelinase (Zn-SMase) originally found in fetal bovine serum, has received little attention since its first and only report 7 years ago. We now show that Zn-SMase activity is secreted by human and murine macrophages, human skin fibroblasts, microglial cells, and several other cells in culture and is markedly up-regulated during differentiation of human monocytes to macrophages. Remarkably, peritoneal macrophages from mice in which the acid SMase gene had been disrupted by homologous recombination secreted no Zn-SMase activity, indicating that this enzyme and the intracellular lysosomal SMase, which is Zn-independent, arise from the same gene. Furthermore, skin fibroblasts from patients with types A and B Niemann-Pick disease, which are known to lack lysosomal SMase activity, also lack Zn-SMase activity in their conditioned media. Chinese hamster ovary cells stably transfected with a cDNA encoding lysosomal SMase massively overexpress both cellular lysosomal SMase and secreted Zn-SMase activities. Thus, Zn-SMase arises independently of alternative splicing, suggesting a post-translational process. In summary, a wide variety of cell types secrete Zn-SMase activity, which arises from the same gene as lysosomal SMase. This secreted enzyme may play roles in physiological and pathophysiological processes involving extracellular sphingomyelin hydrolysis.
Discrimination of bacteria on food using laser-induced bacterial autofluorescence (2000)

This paper updates progress on work1 in detecting bacterial auto-fluorescence against various food backgrounds using Laser-Induced Fluorescence (LIE). The fluorescence of bacteria and various meat products has been measured in order to find suitable excitation and detection wavelengths for discriminative imaging. The optical absorption of bacteria, meat and fish tissue was measured to provide a starting point for the fluorescence measurements. The bacteria measured was Escherichia Coli, and the food tissue products were, lamb, pork, chicken and fish. All absorption spectra have a peak around 400nm and most muscle tissue types have lower absorption around 325nm giving a good low contrast fluorescent background for the F. Coli. However, other tissue types such as fat, skin and bone skin have higher absorption levels and hence fluorescence. Three interference filters can be used to selectively sample the fluorescence spectra to generate a three point intensity ratio that can be used to discriminate between fluorescence of the various tissue types and E. Coli. The best fluorescence discrimination was achieved using the HeCd laser wavelength of 325nm. However in our current experimental setup there is not enough optical power at 325nm for direct laser imaging. We are currently working to increase UV laser excitation levels by using a dye laser to pump a frequency doubling crystal.
Next Generation Solar Array Technologies for Small Satellites (2002)

We describe the rare case of a 76-year-old man with left partial anomalous pulmonary venous connection with intact atrial septum. He experienced dyspnea due to significant aortic stenosis and mitral regurgitation, and required valve repair. Preoperative computed tomography revealed connection of the left upper pulmonary vein to the innominate vein. Although right heart overload was not recognized, we repaired the left partial anomalous pulmonary venous connection with concomitant aortic valve replacement and mitral annuloplasty, because of the potential for unpredictable harmful effects of a residual left-to-right shunt. The patient recovered well with no signs of left upper lung congestion.
Guanosine Tetra- and Pentaphosphate Promote Accumulation of Inorganic Polyphosphate in Escherichia coli (1997)

High levels of guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), generated in response to amino acid starvation in Escherichia coli, lead to massive accumulations of inorganic polyphosphate (polyP). Inasmuch as the activities of the principal enzymes that synthesize and degrade polyP fluctuate only slightly, the polyP accumulation can be attributed to a singular and profound inhibition by pppGpp and/or ppGpp of the hydrolytic breakdown of polyP by exopolyphosphatase, thereby blocking the dynamic turnover of polyP. The Ki values of 10 microM for pppGpp and 200 microM for ppGpp are far below the concentrations of these nucleotides in nutritionally stressed cells. In the complex metabolic network of pppGpp and ppGpp, the greater inhibitory effect of pppGpp (compared with ppGpp) leading to the accumulation of polyP, may have some significance in the relative roles played by these regulatory compounds.
In SituDeposition of Complement in Human Acute Brain Ischaemia (2009)

Experimental animal models indicate that complement contributes to tissue damage during brain ischaemia and stroke, but limited data are available for a role of the complement in human stroke. We, therefore, evaluated whether acute ischaemia leads to complement activation in human brain. Indirect immunohistochemical staining was performed on paraffin-embedded, formalin-fixed human brain from 10 patients and 10 controls. Complement components C1q, C3c and C4d were detected in all ischaemic lesions, suggesting activation via the classical pathway. C9, C-reactive protein and IgM were detected in necrotic zones. Marked CD59 and weak CD55 expression were found in normal brains, but these complement regulators were virtually absent in ischaemic lesions. Modest amounts of mannose-binding lectin (MBL), MBL-associated serine protease-2 and factor B were found in both ischaemic lesions and controls. These data suggest that increased deposition of complement components combined with decreased expression of complement regulators is a possible mechanism of tissue damage during ischaemia in human brain.
Non-invasive in vivo near-infrared optical measurement of the penetration depth in the neonatal head (1991)

The non-invasive optical technique of near-infrared spectroscopy (NIRS) was used to measure the depths of light penetration at four wavelengths in the NIR region. Near-infrared absorbance measurements were carried out on 10 preterm infants. The apparent absorbance data (in optical density units) collected at 775, 805, 845, and 904 nm were measured at different positions on the head. Linear relationships that satisfy the Lambert law were obtained when the apparent absorbance at a given wavelength was plotted against the inter-optrode distance. From the slopes of the resulting straight lines, the depth of penetration of the NIR light was calculated and found to be independent of the position of the probes on the head. Calculated average values of the depth of penetration of near-infrared light in the whole neonatal head ranged between 6.3 and 8.5 mm.
The dppA gene of Bacillus subtilis encodes a new d‐aminopeptidase (2000)

Different strains of Bacillus were screened for their ability to hydrolyse D-alanyl-p-nitroanilide. Activity was detected in Bacillus pumilus, Bacillus brevis, Bacillus licheniformis 749I and Bacillus subtilis 168. The last strain was the best producer and was selected for the production and purification of the enzyme. The determination of the N-terminal sequence identified the enzyme as the product of the dppA gene (previously named dciAA) belonging to the dipeptide ABC transport (dpp) operon expressed early during sporulation. Open reading frames (ORFs) encoding putative related proteins were found in the genomes of a variety of Archaea and both sporulating and non-sporulating bacteria. The enzyme behaves as a D-aminopeptidase and represents the prototype of a new peptidase family. Among the tested substrates, the highest activities were found with D-Ala-D-Ala and D-Ala-Gly-Gly. The active enzyme behaves as an octamer of identical 30 kDa subunits. It exhibits a broad pH optimum, extending between pH 9 and 11. It is reversibly inhibited in the presence of Zn2+ chelators, and the sequence comparisons highlight the conservation of potential Zn-binding residues. As it has been shown by others that null mutations in the dpp operon do not inhibit spore formation, the physiological role of DppA is probably an adaptation to nutrient deficiency.
My experiment with the Flipped Classroom Model (2012)

Results of a experiment with the flipped classroom model in a college Information Literacy class, where "face-to-face students work through the online course modules ahead of class time and then use the in-class time (50 minutes once a week throughout the semester) to participate in activities that would reinforce their learning and allow for more interaction and activity in the classroom."
Cochannel Interference Mitigation and Cooperative Processing in Downlink Multicell Multiuser MIMO Networks (2004)

Recently, the remarkable capacity potential of multiple-input multiple-output (MIMO) wireless communication systems was unveiled. The predicted enormous capacity gain of MIMO is nonetheless significantly limited by cochannel interference (CCI) in realistic cellular environments. The previously proposed advanced receiver technique improves the system performance at the cost of increased receiver complexity, and the achieved system capacity is still significantly away from the interference-free capacity upper bound, especially in environments with strong CCI. In this paper, base station cooperative processing is explored to address the CCI mitigation problem in downlink multicell multiuser MIMO networks, and is shown to dramatically increase the capacity with strong CCI. Both information-theoretic dirty paper coding approach and several more practical joint transmission schemes are studied with pooled and practical per-base power constraints, respectively. Besides the CCI mitigation potential, other advantages of cooperative processing including the power gain, channel rank/conditioning advantage, and macrodiversity protection are also addressed. The potential of our proposed joint transmission schemes is verified with both heuristic and realistic cellular MIMO settings.
Charter School Accessibility For Historically Disadvantaged Students: The Experience in New Jersey (2012)

pdf.Additionally, much of the debate over statewide systems of school funding has been predicated on the concern that historically discriminated students have not been receiving equal or adequate educational funding.These cases have typically focused on students in low-income urban districts districts in which students of racial and ethnic minorities comprise a disproportionate percentage of the enrollment.See
Pathological studies of chickens experimentally infected with two highly pathogenic avian influenza viruses (1996)

Lesions of chickens inoculated with two highly pathogenic avian influenza virus strains, A/turkey/England/50-92/91 (H5N1) and A/chicken/Victoria/1/85 (H7N7) were examined histologically and immunohistochemically. Birds of both treatment groups died within 5 days post-inoculation. The most significant lesions induced by these two viruses consisted of swelling of the microvascular endothelium, systemic congestion, multifocal haemorrhages, perivascular mononuclear cell infiltration, and thrombosis associated with viral antigen in the vascular endothelium and/or perivascular parenchymatous cells. Viral antigen in the cardiac myocytes was consistently detected in all birds. In addition, severe pulmonary congestion and oedema was found in A/turkey/England/50-92/91 virus-inoculated birds that died within 1 day post-inoculation. The other chickens of both groups showed necrotic and inflammatory changes associated with viral antigen in various organs and tissues. These findings suggested that cardiovascular system involvement played an important role in the pathogenesis of these virus infections.
Impact of double Rayleigh scattering noise in distributed higher order Raman pumping schemes (2003)

We analyze the equivalent optical noise figure (NF) performances and double Rayleigh-scattering-induced noise characteristics of distributed Raman amplifiers based on higher order pumping schemes. We confirm that higher order counterpumping configurations improve the amplifier equivalent NF but also increase multipath interference noise, inducing system penalties at high ON-OFF Raman gain. A Q-factor analysis allows a quantitative evaluation of the real benefits provided by higher order pumping schemes.
Ionizing radiation activates transcription of the EGR1 gene via CArG elements. (1992)

The present studies have examined the effects of ionizing radiation on control of the early growth response 1 (EGR1) gene. Exposure of human HL-525 cells to x-rays was associated with increases in EGR1 mRNA levels. Nuclear run-on assays showed that this effect is related at least in part to activation of EGR1 gene transcription. Sequences responsive to ionizing radiation-induced signals were determined by deletion analysis of the EGR1 promoter. The results demonstrate that x-ray inducibility of the EGR1 gene is conferred by a region containing six serum response or CC(A+T-rich)6GG (CArG) motifs. Further analysis confirmed that the region encompassing the three distal or upstream CArG elements is functional in the x-ray response. Moreover, this region conferred x-ray inducibility to a minimal thymidine kinase gene promoter. Taken together, these results indicate that ionizing radiation induces EGR1 transcription through CArG elements.