gebhart/patrepeval huggingface dataset:
High-density lipoprotein cholesterol and premature coronary heart disease in urban Japanese men. (1994)

BACKGROUNDThe objective of this study was to examine the relation of high-density lipoprotein cholesterol (HDL-C) to coronary heart disease in Japanese men whose serum total cholesterol is low by Western standards.METHODS AND RESULTSA prospective, observational study based on 7.7 years of follow-up for incidence of coronary heart disease and stroke was conducted. The subjects were 6408 middle-aged male workers aged 40 to 59 years at baseline in urban companies in Osaka, Japan, whose mean serum total cholesterol was 5.10 mmol/L. Mean HDL-C adjusted for age, total cholesterol, systolic blood pressure, alcohol intake, cigarette smoking, and body mass index was 1.27 to 1.28 mmol/L for men who developed coronary heart disease (n = 46) or definite myocardial infarction (n = 21) compared with 1.46 mmol/L for those free of cardiovascular disease (n = 6256; difference, P < .01). There was no significant difference in mean HDL-C between stroke cases (n = 33) and those free of cardiovascular disease. The incidence r...
Thalidomide Therapy:An Open Trial (1985)

ABSTRACT: In an open trial, 35 patients suffering from a variety of dermatologic conditions were treated with thalidomide. The drug was shown to be a valuable addition to the therapeutic armamentarium; however, the occurrence of a peripheral neuropathy will limit its use just as its teratogenic side effects have done for many years.
Molgramostim (GM-CSF) Associated With Antibiotic Treatment in Nontraumatic Abdominal Sepsis (2006)

Addition of molgramostim to antibiotic therapy reduces the rate of infectious complications, the length of hospitalization, and costs in patients with nontraumatic abdominal sepsis.
Characterization of lipid miscibility in liquid-expanded monolayers at the gas-liquid interface (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of lipid miscibility in liquid-expanded monolayers at the gas-liquid interfaceJ. M. Smaby and H. L. BrockmanCite this: Langmuir 1992, 8, 2, 563–570Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/la00038a042https://doi.org/10.1021/la00038a042research-articleACS PublicationsRequest reuse permissionsArticle Views145Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Civilian and Detainee Orthopaedic Surgical Care at an Air Force Theater Hospital (2007)

This study is a retrospective analysis of the orthopaedic care rendered to Iraqi citizens, both military and civilian, and detainees in Balad, Iraq, at an Air Force theater hospital. Defining the scope of care for this patient group and emphasizing the differences in care provided for the endemic population in contrast to the rapidly air-evacuated Coalition injured combatant are the primary focus of the study. Approximately 50% of more than 1600 trauma/combat-related injury admissions to Air Force Theater Hospital in Balad, Iraq, from the period of September 2, 2005 through January 18, 2006, were Iraqi citizens and detainees. The care rendered to this population differed from the care given to a rapidly air-evacuated patient in that definitive care of all combat wounds, including fracture care and soft tissue management, was the responsibility of the deployed surgeons. Open reduction and internal fixation, definitive debridement, Wound VAC placement (Vacuum-Assisted Closure Device; KCI International, San Antonio, Tex), and final soft tissue management were performed at Air Force Theater Hospital. All patients were treated according to their injuries, including detainees, who received the same level of care as any other injured patient. This article will depict examples of the civilian and detainee orthopaedic care available and performed in a war zone and how that care differed from that rendered to a rapidly evacuated American combatant. Injured Coalition combatants received high-level damage control orthopaedic care and initial debridements, with external fixation as the single most common means of long-bone fracture stabilization. Civilians and detainees seen at Balad received the same high-level care and much, if not all, of their definitive care while at Air Force Theater Hospital. The care rendered to Iraqi citizens and detainees at an Air Force theater hospital is described, with multiple case examples that reflect a high level of definitive care offered in a war zone.
Gelation Mechanism of Tetra-armed Poly(ethylene glycol) in Aprotic Ionic Liquid Containing Nonvolatile Proton Source, Protic Ionic Liquid (2015)

We report the gelation mechanism of tetra-armed prepolymer chains in typical aprotic ionic liquid (aIL), i.e., A-B type cross-end coupling reaction of tetra-armed poly(ethylene glycol)s with amine and activated ester terminals (TetraPEG-NH2 and TetraPEG-NHS, respectively) in 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)amide ([C2mIm][TFSA]). In the ion gel system, we focused on the pH (or H(+) concentration) dependence of the gelation reaction. We thus applied the protic ionic liquid (pIL), 1-ethylimidazolium TFSA ([C2ImH][TFSA]), as a nonvolatile H(+) source, and added it into the solvent aIL. It was found that the gelation time of TetraPEG ion gel can be successfully controlled from 1 min to 3 h depending on the concentration of pIL (cpIL = 0-3 mM). This suggests that the acid-base properties of TetraPEG-NH2 showing acid-base equilibrium (-NH2 + H(+) ⇆ -NH3(+)) in the solutions play a key role in the gelation process. The acid dissociation constants, pKa's of TetraPEG-NH3(+) and C2ImH(+) (cation of pIL) in aIL were directly determined by potentiometric titration to be 16.4 and 13.7, respectively. This indicates that most of the H(+) ions bind to TetraPEG-NH2 and then C2ImH(+) exists as neutral C2Im. The reaction efficiency of amide bond (cross-linked point) systematically decreased with increasing cpIL, which was reflected to the mechanical strength of the ion gels. From these results, we discuss the gelation mechanism of TetraPEG in aIL to point out the relationship between polymer network structure and [H(+)] in the solutions.
Long‐term testosterone therapy in hypogonadal men ameliorates elements of the metabolic syndrome: an observational, long‐term registry study (2013)

Long-term T therapy, at physiological levels, ameliorates MetS components. These findings strongly suggest that T therapy in hypogonadal men may prove useful in reducing the risk of cardiometabolic diseases.
Hobbes' Internet Timeline (1997)

This document presents a history of the Internet in timeline fashion,
highlighting some of the key events and technologies which helped
shape the Internet as we know it today. A growth summary of the
Internet and some associated technologies is also included. This memo
provides information for the Internet community. It does not specify
an Internet standard of any kind.
Oxidation of D-lactate and L-lactate by Neisseria meningitidis: purification and cloning of meningococcal D-lactate dehydrogenase (1993)

Neisseria meningitidis was found to contain at least two lactate-oxidizing enzymes. One of these was purified 460-fold from spheroplast membranes and found to be specific primarily for D-lactate, with low-affinity activity for L-lactate. The gene for this enzyme (dld) was cloned, and a dld mutant was constructed by insertional inactivation of the gene. The mutant was unable to grow on D-lactate but retained the ability to grow on L-lactate, providing evidence for a second lactate-oxidizing enzyme with specificity for L-lactate. High-affinity L-lactate-oxidizing activity was detected in intact bacteria of both the dld+ and dld mutant strains. This L-lactate-oxidizing activity was also seen in sonicated bacteria but was reduced substantially on detergent solubilization or on preparation of spheroplast membranes.
Practical phase-shifting mask technology for 0.3 μm large scale integrations (1994)

An i-line phase-shifting mask technology intended for practical use has been developed. The new technology can provide defect-free phase-shifting masks and can produce 0.3 μm large scale integration with large lithographic latitudes. The phase-shifting masks manufactured here apply the following two major techniques. The first technique is to form phase-shifting patterns on the chrome mask. This technique features single-layer shifters using an organic spin on glass (SOG), a simple patterning process of the SOG, and a focused ion beam gas-assisted etching repair process of shifter defects. The second technique is to create half-micron chrome patterns using a high-accuracy e-beam writing system ‘‘EB-MX’’ and high-resolution chemically amplified e-beam resist ‘‘PSR’’.
Creating Speech and Language Data With Amazon's Mechanical Turk (2010)

In this paper we give an introduction to using Amazon’s Mechanical Turk crowdsourcing platform for the purpose of collecting data for human language technologies. We survey the papers published in the NAACL-2010 Workshop. 24 researchers participated in the workshop’s shared task to create data for speech and language applications with $100.
Insertion, expression and physiology of growth-regulating genes in ruminants. (1990)

Transgenic sheep with elevated concentrations of circulating growth hormone (GH) were produced by microinjecting recombinant DNA into pronuclei of zygotes. The transgenes were fusion genes of non-GH promoters with coding sequences of various growth hormone genes including human, ovine or bovine. In addition, sheep transgenic with the human growth hormone releasing factor gene were produced. Non-GH promoters for fusion genes allowed novel regulation of GH production in ectopic tissues, including the kidney, liver and gut. Elevated levels of GH profoundly altered plasma IGF-1 without significantly altering rate of growth or feed efficiency. Carcass composition was altered with reduced fat. Elevated GH induced diabetes, resulting in death by 1 year of age. These studies indicate the need for improved regulation of inserted genes or investigation of alternative systems, such as GH receptors, to improve growth using the transgenic approach in ruminants.
A PROBABLE NEW HUMAN PICORNAVIRUS ASSOCIATED WITH RESPIRATORY DISEASE1 (1967)

Journal Article A PROBABLE NEW HUMAN PICORNAVIRUS ASSOCIATED WITH RESPIRATORY DISEASE Get access JACK H. SCHIEBLE, JACK H. SCHIEBLE Search for other works by this author on: Oxford Academic PubMed Google Scholar VIRGINIA L. FOX, VIRGINIA L. FOX Search for other works by this author on: Oxford Academic PubMed Google Scholar EDWIN H. LENNETTE EDWIN H. LENNETTE Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 85, Issue 2, March 1967, Pages 297–310, https://doi.org/10.1093/oxfordjournals.aje.a120693 Published: 01 March 1967 Article history Received: 15 July 1966 Published: 01 March 1967
The structure based design of dual HDAC/BET inhibitors as novel epigenetic probes (2014)

DUAL946 (1) inhibits BET and HDAC proteins in chemoproteomic cell lysate experiments and in immune and cancer cells.
In Vivo Evaluation of Autologous Cartilage Fragment-Loaded Scaffolds Implanted into Equine Articular Defects and Compared with Autologous Chondrocyte Implantation (2009)

Given these results with the CAIS procedure, testing in human patients is the next logical step (a phase 1 human clinical study has proceeded from this work).
Eribulin Induces Irreversible Mitotic Blockade: Implications of Cell-Based Pharmacodynamics for In vivo Efficacy under Intermittent Dosing Conditions (2010)

Eribulin (E7389), a mechanistically unique microtubule inhibitor in phase III clinical trials for cancer, exhibits superior efficacy in vivo relative to the more potent compound ER-076349, a fact not explained by different pharmacokinetic properties. A cell-based pharmacodynamic explanation was suggested by observations that mitotic blockade induced by eribulin, but not ER-076349, is irreversible as measured by a flow cytometric mitotic block reversibility assay employing full dose/response treatment. Cell viability 5 days after drug washout established relationships between mitotic block reversibility and long-term cell survival. Similar results occurred in U937, Jurkat, HL-60, and HeLa cells, ruling out cell type-specific effects. Studies with other tubulin agents suggest that mitotic block reversibility is a quantifiable, compound-specific characteristic of antimitotic agents in general. Bcl-2 phosphorylation patterns parallel eribulin and ER-076349 mitotic block reversibility patterns, suggesting persistent Bcl-2 phosphorylation contributes to long-term cell-viability loss after eribulin's irreversible blockade. Drug uptake and washout/retention studies show that [3H]eribulin accumulates to lower intracellular levels than [3H]ER-076349, yet is retained longer and at higher levels. Similar findings occurred with irreversible vincristine and reversible vinblastine, pointing to persistent cellular retention as a component of irreversibility. Our results suggest that eribulin's in vivo superiority derives from its ability to induce irreversible mitotic blockade, which appears related to persistent drug retention and sustained Bcl-2 phosphorylation. More broadly, our results suggest that compound-specific reversibility characteristics of antimitotic agents contribute to interactions between cell-based pharmacodynamics and in vivo pharmacokinetics that define antitumor efficacy under intermittent dosing conditions.
Diffusion-Enhanced Fluorescence Energy Transfer (1982)

Many bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated (Cas) systems employ the dual RNA–guided DNA endonuclease Cas9 to defend against invading phages and conjugative plasmids by introducing site-specific ...Read More
Immunohistochemical analysis of cytokeratin #8 as a prognostic factor in invasive breast carcinoma. (1995)

Cytokeratin #8 (CK8) was analysed by immunohistochemistry using a monoclonal antibody in 101 operable invasive breast carcinomas (IBCs). The immunohistochemical staining pattern, and its correlations with patient characteristics and prognosis were studied. Sixty-five (65%) out of 101 patients had CK8 positive tumors. The incidence of CK8 positivity in patients with estrogen receptor (ER) positive tumors was significantly higher than that in patients with ER negative tumors. The same tendency was seen between the CK8 positivity and progesterone receptor (PR) status; however, no statistical significance was found. Furthermore, the incidence of CK8 positivity in premenopausal patients was lower than that in postmenopausal patients with no statistical significance. Relapse-free survival (RFS) for patients with CK8 positive tumors was significantly better than that for patients with CK8 negative tumors. The multivariate analysis of factors related to RFS showed that CK8 staining positivity was an independent prognostic indicator of IBCs. These results suggest that CK8 expression may be one of the prognostic factors of IBCs.
Sildenafil Effects on Exercise, Neurohormonal Activation, and Erectile Dysfunction in Congestive Heart Failure (2002)

Sildenafil was tolerated and effective for ED treatment in CHF, and improved the exercise capacity. The reduction of HR during exercise with sildenafil could theoretically decrease the myocardial oxygen consumption during sexual activity.
A facile route to hollow nanospheres of mesoporous silica with tunable size (2008)

Hollow mesoporous silica nanospheres (HMSNs) with tunable sizes of both sphere diameter (around 100 nm) and shell thickness have been successfully fabricated.
Rapid Generation of Cytomegalovirus Specific T Lymphocytes Using Commercially Available CMV pp65 Peptides. (2006)

Abstract Adoptive immunotherapy with cytomegalovirus (CMV) specific cytotoxic T lymphocytes (CTL) can result in resolution of viremia and reconstiution of CMV specific immunity following allogeneic stem cell transplantation. Most recipients of allogeneic transplants who develop CMV reactivation are successfully treated with anti-viral agents, however some have persistent viremia or develop CMV disease despite these medications. In these situations the development of CMV specific T cells may be impractical due to time contraints or institutional limitations. We have expanded CMV pp65 specific CTL from 5/6 normal blood donors of diverse HLA backgrounds in 10–15 days using adherent cells (monocytes) as antigen presenting cells, pulsed with a commercially available source of CMV pp65 peptides, which includes 138 CMV pp65 15mers. These pulsed monocytes are incubated at a 1:5 ratio with non-adherent peripheral blood lymphocytes, resulting in a population of CD4 and CD8+ CMV pp65 specific T cells after 2 weekly stimulations. While &amp;gt;80% of these cells were CD3+, 29–78% were CD4+, and 15–55% were CD8+. These CTL have specific cytotoxicity against CMV pp65, and intracellular cytokine analysis showed specific interferon-gamma production in response to CMV pp65 target cells. Table I depicts the phenotype as well as interferon-gamma production and specific cytotoxicity in response to stimulation with B lymphoblastoid cell lines (BLCL) expressing pp65. There was no reactivity to allogeneic targets by cytokine analysis or in chromium release assays. CTL sufficient for a dose of 30–50 × 106 CTL were routinely generated from 40–50 cc of whole blood. Considering the short time frame and relative ease with which these CTL can be expanded, this methodology could be readily adopted in clinical situations of persistent or therapy refractory CMV infections in allogeneic stem cell transplant patients as an adjuvant to anti-viral therapy. Characteristics of CMVpp65 CTL Interferon production Cytotoxicity Donor CD4 CD8 BLCL-pp65 BLCL Allo BLCL 1 1% 23% 57% 1% 1% 2 2% 3% 75% 22% 6% 3 6% 1% 31% 7% 7% 4 9% 29% 47% 0% 0% 5 7% 15% 69% 1% 5% 6 24% 3% 10% 1% 6%
Pelvic Ring Disruptions: Prediction of Associated Injuries, Transfusion Requirement, Pelvic Arteriography, Complications, and Mortality (2002)

Shock on arrival and the Revised Trauma Score are useful predictors of mortality and transfusion requirements, Injury Severity Score, and Abbreviated Injury Scores for the head and neck, face, chest, abdomen, and extremities. In addition, the Revised Trauma Score predicts the use of pelvic arteriography and later complications. Age predicted transfusion requirement, Injury Severity Score, the chest and skin Abbreviated Injury Scores, use of arteriography, and death.
Microseismic Imaging of Hydraulic Fracture Complexity in the Barnett Shale (2002)

Abstract Microseismic monitoring has been used to image hydraulic fracture growth in the Barnett Shale. The Barnett is a naturally fractured shale reservoir, which causes significant complexity in fracture growth during well stimulation operations. Several Barnett treatments have been successfully imaged between March 2000 and December 2001. In this paper, examples will be given to illustrate the complexity and variability which is developed during the treatment as the slurry interacts with the pre-existing fracture sets. The microseismic images explain why the stimulations occasionally grow at an angle to the assumed fracture orientation and into neighboring wells. Differences in production rates from various wells could also be related to the fracture geometry. The implications of the images to reservoir management highlight the benefit of imaging individual fracture networks to avoid overlapping and for targeting potential new well locations.
Speed of Movement under Two Conditions of Response-Initiation in Retardates (1972)

The speed of performing a simple ballistic movement under two conditions of response-initiation, stimulus-cued and self-cued, was studied with 24 educable retardates. Also, the effects of stimulus intensity (50 and 70 db re threshold) and sex were examined using a 2 × 2 × 2 factorial design. All main effects, but no interactions, were significant. The slower ballistic speed observed under the self-cued condition was attributed to a deficient capacity for self-arousal.
Enzymatic Preparation of Metabolic Intermediates, 3-Dehydroquinate and 3-Dehydroshikimate, in the Shikimate Pathway (2006)

A method for enzymatic preparation of 3-dehydroquinate and 3-dehydroshikimate in the shikimate pathway was established by controlling the enzyme activity of 3-dehydroquinate dehydratase. When quinate was incubated with the membrane fraction of acetic acid bacteria at pH 5.0, 3-dehydroquinate was formed as the predominant product. 3-Dehydroshikimate was the sole product when incubated at pH 8.0. Mutual separation of the metabolic intermediates was also exemplified.
The Insulin-Like Growth Factor I Receptor as a Physiologically Relevant Target of p53 in Apoptosis Caused by Interleukin-3 Withdrawal (1997)

The wild-type p53 protein is known to modulate apoptosis induced in 32D murine hemopoietic cells by interleukin-3 withdrawal. In 32D cells and in 32D cells constitutively expressing a temperature-sensitive mutant of p53 (32Dtsp53), overexpression of a wild-type (but not a mutant) insulin-like growth factor I receptor (IGF-IR) protects these cells from apoptosis. A tsp53 in its wild-type conformation causes a decrease in the levels of IGF-IRs, and this decrease is accompanied by increased sensitivity of these cells to apoptosis. However, when the expression of the IGF-IR cDNA is regulated by a viral promoter, IGF-IR levels are not decreased by a wild-type p53, and apoptosis does not occur. These findings show that, in 32Dtsp53 cells, the IGF-IR is a physiologically relevant target of p53 in the process of apoptosis.
VHS VCR with Index and Address Search Systems (1987)

Newly developed, highly useful random access features have been incorporated into a recently introduced VHS Format video cassette recorder. Two types of random access are provided. One is for locating the start of a desired program ("Index"), while the other is capable of locating specific points throughout the length of the tape ("Address").
Two-step Atomic Layer Deposition for Tantalum Nitride by Nitridation of Tantalum with Ammonia (2006)

Abstract not Available.
The appearance and characteristics of early pregnancy factor in the pig (1983)

The occurrence of early pregnancy factor in the pig has been established by the rosette inhibition test and by the criteria that gel filtration of serum resulted in a number of peaks of activity similar to those observed in other species. In the pig EPF is present virtually to the end of pregnancy, with a biphasic production in which the titres of EPF decline markedly in mid-pregnancy. Free EPF-A appears concurrently with EPF in the first 3 weeks of pregnancy in some but not all pigs. The presence of excess EPF-A has an inhibitory effect in the rosette inhibition test and modifications, including an initial serum dialysis step, have been introduced into the test to take account of this inhibitory effect.