gebhart/patrepeval huggingface dataset:
Simulated Efficiency of Range Beef Production. III. Culling Strategies and Nontraditional Management Systems (1987)

A modified version of the Texas A&M Beef Cattle Production Model was used to simulate life-cycle biological and economic efficiency of various culling strategies and non-traditional management systems in a northern plains, range environment. Biological efficiency was defined as the ratio of TDN input (kg) to product output (kg), and economic efficiency was defined as the ratio of cost ($) to product output (100 kg), where products were live weight at weaning (LWW), empty body weight at slaughter (EBW) and fat-free weight at slaughter (FFW). Several economic scenarios were simulated. Culling cows at younger ages increased biological efficiency, but not necessarily economic efficiency. The simulated optimal age at culling was 8 yr, the same age at which simulated feed intake and milk production began to decline. Finishing young cows in the feedlot had little effect on biological efficiency and generally increased economic efficiency, although specific results depended on feed prices and relative values of cull cows vs fed animals. A simulated sex-controlled system in which only heifer calves were produced, while extremely biologically efficient for production of lean, resulted in relatively little output and was not economically efficient in most cases. Sex control combined with feeding of 2-yr-old cows was economically efficient, but not markedly more efficient than a conventional system. Results suggest that sex-controlled systems may be more appropriate where emphasis is on lean product and heifers can be bred at very early ages. General results indicate that producers should pay attention to relative values of cull cows and fed animals in choosing culling strategies and management systems.
[Antitumor activity of trewiasine in vitro and in vivo]. (1988)

Trewiasine (TWS) is a maytansinoid isolated from Trewia nudiflora seeds, a natural product from the Xishuangbanna area of China. This study demonstrates that TWS possesses a significant anti-tumor activity in vitro and in vivo. TWS 2.5-10 vg/(kg-d) x7 d ip prolonged the life-span of Ehrlich carcinoma and leukemia P388-bearing mice by 100-183% and 58-81%, respectively. The cure rate of TWS for leukemia P388-bearing mice was 56-75%. TWS lO-8-10-2 vg/ml inhibited the growth rate of P388 cultured cells remarkably. TWS inhibited the incorporation of [3H] leucine into cell protein with T/C% by 19-24%, but it had no significant effect on the incorporation of [3H]thymidine into DNA in cell culture.
Ablation of Undifferentiated Human Embryonic Stem Cells: Exploiting Innate Immunity Against the Gal α1-3Galβ1-4GlcNAc-R (α-Gal) Epitope (2006)

Although undifferentiated human embryonic stem cells (hESCs) are tumorigenic, this capacity is lost after differentiation, and hESCs are being widely investigated for applications in regenerative medicine. To engineer protection against the unintentional transplantation of undifferentiated cells, we generated hESCs carrying a construct in which the alpha1,3-galactosyltransferase (GalT) open reading frame was transcribed from the hTERT promoter (pmGT). Because the endogenous GalT gene is inactive, GalT expression was limited to undifferentiated cells. A second chimeric construct (pmfGT) differed by replacement of the GalT leader sequence for that of the fucosyltransferase gene. Two subclones containing stable integrations of pmGT and pmfGT (M2 and F11, respectively) were assessed for their response to human serum containing antibodies to the Galalpha1-3Galbeta1-4GlcNAc-R (alpha-gal) epitope. The low-variegation line, M2, and to a lesser extent the more variegated line F11, were sensitive to human serum when exposed in the undifferentiated state. However, M2 cells were largely insensitive after differentiation and retained both a normal karyotype and the ability to differentiate into derivatives of the three germ layers in severe combined immunodeficient mice. These data exemplify a method of protection against residual, undifferentiated hESCs prior to engraftment and may provide ongoing immune surveillance after engraftment against dedifferentiation or against de novo tumorigenesis involving hTERT reactivation. Untransfected H9 cells were not sensitive to the human serum used in this study. Hence, in our system, interactions of hESCs with other circulating antibodies, such as anti-Neu5Gc, were not observed.
Hypertension and Endothelial Dysfunction in Apolipoprotein E Knockout Mice (1999)

Mice lacking ApoE (Apoe(-/-)) develop initially hypercholesterolemia and lastly atherosclerosis. This study examined hemodynamics and endothelial function in 6-week-old Apoe(-/-) mice with hypercholesterolemia only, 7.5-months-old Apoe(-/-) mice with both hypercholesterolemia and atherosclerosis, and age matched controls. One day after implantation of catheters into the carotid artery, arterial pressure was measured in conscious, unrestrained mice. Compared with the respective controls, there was a significant increase in arterial pressure and the ratio of left ventricular weight to body weight in 7.5-month-old Apoe(-/-) mice but not in 6-week-old Apoe(-/-) mice. Histopathological analysis demonstrated significant renal artery disease in the form of extensive atheromatous plaques only in 7.5-month-old Apoe(-/-) mice, whereas no atherosclerotic lesions were found in 6-week-old Apoe(-/-) mice. For evaluation of endothelial function, a laser Doppler perfusion imager with a computer-controlled optical scanner was used to measure cutaneous blood perfusion on the dorsal side of one hind paw before and after topical application of mustard oil, which is known to induce nitric oxide-mediated vasodilation. The mustard oil treatment elicited a substantial increase in blood perfusion (P<0.01), which was similar between 6-week-old Apoe(-/-) mice and controls but significantly blunted in 7.5-month-old Apoe(-/-) mice versus control mice, suggesting nitric oxide-mediated vasodilation is diminished in 7.5-month-old Apoe(-/-) mice but not in 6-week-old Apoe(-/-) mice. In contrast, the increase in blood perfusion induced by topical administration of cilostazol, which induces vasodilation via cyclic adenosine monophosphate, was not different between 7.5-month-old Apoe(-/-) mice and controls. Thus hypertension and endothelial dysfunction observed in 7.5-month-old Apoe(-/-) mice may be due mainly to atherosclerosis.
Second-line therapy with paclitaxel and carboplatin for recurrent disease following first-line therapy with paclitaxel and platinum in ovarian or peritoneal carcinoma. (1998)

The use of this combination, in this sensitive population, has a high response rate and long progression-free interval. In a chemotherapy-sensitive population, the activity of alternative second-line agents must be interpreted with this perspective.
The application of AdaBoost for distributed, scalable and on-line learning (1999)

We propose to use AdaBoost to efficiently learn classifiers over very large and possibly distributed data sets that cannot fit into main memory, as well as on-line learning where new data become available periodically. We propose two new ways to apply AdaBoost. The first allows the use of a small sample of the weighted training set to compute a weak hypothesis. The second approach involves using AdaBoost as a means to re-weight classifiers in an ensemble, and thus to reuse previously computed classifiers along with new classifier computed on a new increment of data. These two techniques of using AdaBoost provide scalable, distributed and on-line learning. We discuss these methods and their implementation in JAM, an agent-based learning system. Empirical studies on four real world and artifical data sets have shown results that are either comparable to or better than learning classifiers over the complete training set and, in some cases, are comparable to boosting on the complete data set. However, our algorithms use much smaller samples of the training set and require much less memory.
Bcl-2 inhibits retinoic acid-induced apoptosis during the neural differentiation of embryonal stem cells. (1996)

We report here that all trans-retinoic acid (RA), a classical morphogen, induces apoptosis during the neural differentiation of the embryonic stem cell line P19. The apoptotic cells showed, in addition to DNA cleavage, typical morphological changes including chromatin condensation, nuclear fragmentation, and cytoplasmic vacuolation. These apoptotic changes became obvious by 12 h after the addition of RA. The endogenous expression of bcl-2 in surviving cells was down-regulated during this process, and the compelled expression of bcl-2 by retroviral vectors reduced the number of apoptotic cells. Apoptosis was partially inhibited by adding antisense oligonucleotides against RA receptors (RARs) simultaneously or by transfecting a plasmid vector flanked with a RA-responsive element. Antisense oligonucleotides against retinoid X receptors (RXRs), the receptors for 9 cis-RA, did not inhibit apoptosis induced by all trans-RA. Cycloheximide and actinomycin D, inhibitors of protein and RNA syntheses, respectively, suppressed apoptosis. No changes were seen in the expression of tumor necrosis factors, their receptors, Fas, FasL, p53, or c-myc, molecules which have been suggested to participate in the apoptotic process. Addition of neurotrophins to the culture medium did not affect apoptosis. These findings suggest that the signals themselves, promote expression of molecules essential for apoptosis. Furthermore, we observed that RA induced apoptosis of cerebral neurons from murine embryos in primary culture, which suggests that RA might participate in cell death which occurs during neural development.
<title>Diamond-based field emission displays</title> (1995)

With the advent of portable electronics and HDTV, there has been much activity in the development of flat panel displays. Flat panel displays are a key component and product differentiator for a variety of electronic products including portables, instrumentation, computers, and entertainment. They are frequently the most visible, costly, and difficult to obtain product component. Currently, the high performance flat panel display industry is dominated by Japanese manufacturers of active matrix liquid crystal displays (AM-LCD). In AM-LCDs, a thin-film transistor is fabricated underneath each pixel to control it more efficiently. The performance is thus improved, but at the expense of an increase in display complexity. Micron-size lithography and alignment capabilities similar to those used for integrated circuits are needed over large display areas. As a consequence AM-LCD manufacturing requires a large capital investment for the VLSI-type equipment that is needed and yields have been increasing only at a slow pace, thus keeping the display costs high. In addition, LCDs are a non-emissive display technology requiring a backlight. This entails an inefficient power use and brightness limitations. Only a small percentage of the emitted light actually makes it through the LCD. Due to these problems, even the most aggressive forecasts do not project AM-LCDs larger than about 18".
Single-Step Solubilization and Folding of IGF-1 Aggregates from Escherichia coli (1993)

A significant amount of IGF-1 can be expressed using the LamB signal sequence in E. coli (1 ). However, more than 90% of the IGF-1 protein forms insoluble protein aggregates (refractile particles), presumably in the periplasm. These protein aggregates are not detected by IGF-1 radioimmunoassay (RIA) and exhibit no appreciable bio-activity. A very simple, one step protein folding protocol was developed for the aggregated IGF-1. The inactive protein is solubilized using low concentrations of urea and DTT in an alkaline buffer. The protein is solubilized and folded in the same solution. Therefore, a denaturant removal or dilution step is not required. Recovery of correctly folded, active protein is dramatically affected by protein concentration and solvent conditions.
Self-Critical Sequence Training for Image Captioning (2017)

Recently it has been shown that policy-gradient methods for reinforcement learning can be utilized to train deep end-to-end systems directly on non-differentiable metrics for the task at hand. In this paper we consider the problem of optimizing image captioning systems using reinforcement learning, and show that by carefully optimizing our systems using the test metrics of the MSCOCO task, significant gains in performance can be realized. Our systems are built using a new optimization approach that we call self-critical sequence training (SCST). SCST is a form of the popular REINFORCE algorithm that, rather than estimating a baseline to normalize the rewards and reduce variance, utilizes the output of its own test-time inference algorithm to normalize the rewards it experiences. Using this approach, estimating the reward signal (as actor-critic methods must do) and estimating normalization (as REINFORCE algorithms typically do) is avoided, while at the same time harmonizing the model with respect to its test-time inference procedure. Empirically we find that directly optimizing the CIDEr metric with SCST and greedy decoding at test-time is highly effective. Our results on the MSCOCO evaluation sever establish a new state-of-the-art on the task, improving the best result in terms of CIDEr from 104.9 to 114.7.
Glucagon-Like Peptide 1-Based Therapies for Type 2 Diabetes: A Focus on Exenatide (2005)

IN BRIEF Therapies based on the incretin hormone glucagon-like peptide 1 are novel treatment options for type 2 diabetes that act through a variety of complementary mechanisms. Exenatide, which will likely become the first application to reach the market, has shown promise in phase III trials in reducing hemoglobin A1c without causing significant hypoglycemia or weight gain.
Antisense inhibition of laminin-8 expression reduces invasion of human gliomas in vitro. (2003)

Using gene array technology, we recently observed for the first time an up-regulation of laminin alpha4 chain in human gliomas. The data were validated by semiquantitative reverse transcription-PCR for RNA expression and immunohistochemistry for protein expression. Moreover, increase of the alpha4 chain-containing laminin-8 correlated with poor prognosis for patients with brain gliomas. Therefore, we hypothesized that inhibition of laminin-8 expression by a new generation of highly specific and stable antisense oligonucleotides (Morpholino) against chains of laminin-8 could slow or stop the spread of glioma and its recurrence and thus might be a promising approach for glioma therapy. We next sought to establish an in vitro model to test the feasibility of this approach and to optimize conditions for Morpholino treatment. To develop a model, we used human glioblastoma multiforme cell lines M059K and U-87MG cocultured with normal human brain microvascular endothelial cells (HBMVEC). Using Western blot analysis and immunohistochemistry, we confirmed that antisense treatment effectively blocked laminin-8 protein synthesis. Antisense oligonucleotides against both alpha4 and beta1 chains of laminin-8 were able to block significantly the invasion of cocultures through Matrigel. On average, the invasion was blocked by 62% in cocultures of U-87MG with HBMVEC and by 53% in cocultures of M059K with HBMVEC. The results show that laminin-8 may contribute to glioma progression and recurrence not only as part of the neovascularization process but also by directly increasing the invasive potential of tumor cells.
Constructing and Reasoning about Alternative Frames of Discernment (2010)

Abstract⎯We construct alternative frames of discernment from input belief functions. We assume that the core of each belief function is a subset of a so far unconstructed frame of discernment. The alternative frames are constructed as different cross products of unions of different cores. With the frames constructed the belief functions are combined for each alternative frame. The appropriateness of each frame is evaluated in two ways: (i) we measure the aggregated uncertainty (an entropy measure) of the combined belief functions for that frame to find if the belief functions are interacting in interesting ways, (ii) we measure the conflict in Dempster’s rule when combining the belief functions to make sure they do not exhibit too much internal conflict. A small frame typically yields a small aggregated uncertainty but a large conflict, and vice versa. The most appropriate frame of discernment is that which minimizes a probabilistic sum of the conflict and a normalized aggregated uncertainty of all combined belief functions for that frame of discernment. Keywords: Dempster-Shafer theory, belief function, representation, frame of discernment, induction. I.
Comparative impact of treatment on patient reported outcomes (PROs) in patients with glioblastoma (GBM) enrolled in RTOG 0825. (2013)

2003 Background: RTOG 0825 tested if adding bevicizumab (BEV) to standard chemoradiation improves survival (OS) or progression free survival (PFS) in newly diagnosed GBM. While OS was equivalent, PFS was longer with Bev (Arm 2) than with placebo (Arm 1). Patients completed quality of life and symptom PROs to evaluate clinical benefit. Methods: The M.D. Anderson Symptom Inventory-Brain Tumor Module (MDASI-BT) and the EORTC core Quality of life Questionnaire and brain tumor module (EORTC QLQ-C30/BN20), were completed by pts at baseline (B) and longitudinally (wk 6, 10, 22, 34, and 46) while on study. The difference between treatment arms were compared from B with evaluation in subsequent weeks in those pts without disease progression; and early change (EC) (baseline to wk 10) between those with and without progression as predictors for OS and PFS. Results: 542pts consented to participate on this trial, and 507 randomized pts participated, with completion of forms by 94% at baseline, 75% at wk 10, 61% at wk 22, and 58% at wk 34. There was a trend for all MDASI-BT symptom groupings to be worse in Arm 2, with significant findings in treatment symptoms at wk 22 and wk 34; both affective and generalized disease symptoms were also significantly worse. For EORTCQLQ30/BN20, differential effects varied at each time point, with no persistent differences. For the MDASI-BT, B neurologic symptom grouping and EC in cognitive symptoms were prognostic for both OS and PFS. For the EORTC QLQ30/BN20, global QOL and motor dysfunction at B as well as EC in communication and leg weakness were prognostic for OS; whereas physical function at B and EC in headaches, seizures, and weak legs were prognostic for PFS. Conclusions: The longitudinal collection of PROs in this phase III trial revealed important treatment-related differences as there was overall more deterioration in symptoms and QOL in Arm 2 as compared to Arm 1, with persistent significant differences in treatment associated symptoms. B and EC tumor associated symptoms on both PRO tools were prognostic for OS and PFS. Longitudinal modeling is ongoing to further assess for differential impact of treatment on symptoms and QOL. Support: U10 CA21661, U10 CA37422 and Genentech, Inc. Clinical trial information: NCT00884741.
Mortality from coronary heart disease and stroke in relation to degree of glycaemia: the Whitehall study. (1983)

In the Whitehall study of 18 403 male civil servants aged 40-64 years the 10 year mortality rates from coronary heart disease and stroke showed a non-linear relation to two hour blood glucose values, with a significantly increased risk for glucose intolerant subjects with concentrations above the 95th centile point (5.4-11.0 mmol/l; 96-199 mg/100 ml) and for diabetics (blood glucose greater than or equal to 11.1 mmol/l; greater than or equal to 200 mg/100 ml). Multiple logistic analysis showed that between one half and three quarters of the relative risks for deaths from coronary heart disease and stroke were "unexplained" by between group differences in risk factors such as age, blood pressure, obesity, smoking, cholesterol concentration, and electrocardiographic abnormalities. Within the glucose intolerant and diabetic groups the risk factors most strongly related to subsequent death from coronary heart disease were age and blood pressure, with less consistent relations for smoking, cholesterol concentration, and obesity. This study confirms the importance of hypertension as a cardiovascular risk factor in groups with glucose intolerance and diabetes, and this may have important preventive implications.
Pulsatile delivery of amoxicillin against Streptococcus pneumoniae (2004)

Pulsatile dosing, which involves administration of the total daily dose over the first 6 h of the day, may represent a unique and alternative strategy for dosing beta-lactam antimicrobials.
Desempeño del personal docente y asignación de estímulos económicos en las Universidades Públicas Estatales (UPE) en México (2013)

Resumen
Este estudio aborda el tema del Programa de Estimulos al Desempeno Docente en las Universidades Publicas Estatales (UPE) en Mexico. El diseno de la investigacion es cuantitativo, no experimental de tipo transeccional. La poblacion de analisis son las Universidades Publicas Estatales en Mexico y las categorias de analisis consideradas son: Profesores de Tiempo Completo (PTC), PTC con perfil Promep y PTC que pertenecen al Sistema Nacional de Investigadores ( SIN); los datos se han analizado en un sistema electronico y la tecnica de analisis aplicada es descriptiva. La investigacion parte del supuesto de que el apoyo de estimulos al desempeno academico incide en el incremento de la produccion cientifica del profesorado, y tiene como proposito describir la produccion cientifica derivada de los apoyos economicos recibidos por el programa. En el reporte se abordan aspectos sobre el Programa de Estimulos al Desempeno Docente en su contexto nacional, antecedentes, lineamientos generales para la operacion del programa, los resultados, y por ultimo las conclusiones derivadas del estudio.
 Palabras clave: Desempeno docente, educacion superior.
Erythrocyte P Antigen: Cellular Receptor for B19 Parvovirus (1993)

The pathogenic human parvovirus B19 replicates only in erythroid progenitor cells. This virus was shown to bind to blood-group P antigen, as measured by hemagglutination. Erythrocytes lacking P antigen were not agglutinated with B19. Purified P antigen (globoside) blocked the binding of the virus to erythroid cells and the infectivity of the virus in a hematopoietic colony assay. Target cells were protected from infection by preincubation with monoclonal antibody to globoside. Knowledge of a parvovirus receptor has implications for understanding the pathogenesis of parvovirus infections and for the use of parvoviruses in gene therapy.
Affinity for Dopamine D2, D3, and D4Receptors of 2-Aminotetralins. Relevance of D2Agonist Binding for Determination of Receptor Subtype Selectivity (1996)

A series of 2-aminotetralins, substituted with a methoxy or a hydroxy group on the 5- or 7-position, and with varying N-alkyl or N-arylalkyl substituents, were prepared and evaluated in binding assays for human dopamine (DA) D2, D3, and D4 receptors. Some members of this series were prepared in former studies, but were never tested in vitro with single receptor subtypes, and these were examined again. None of the tested 2-aminotetralins showed high affinity for the dopamine D4 receptor. However, a number of the 2-aminotetralins showed high affinity for both the D2 and the D3 DA receptors, as exemplified by compounds 11-15 and 21-26, while some had a reasonable selectivity for the DA D3 receptors. The affinities of the 2-aminotetralins for the D21, receptor depended on the type of radioligand (agonist or antagonist) used. The agonist affinity data, obtained by using the agonist ligand [3H]N-0437, are thought to be more relevant for calculating DA receptor subtype selectivity.