Prostate Specific Antigen in the Diagnosis and Treatment of Adenocarcinoma of the Prostate. II. Radiation Treated Patients (1989)

No AccessJournal of Urology1 May 1989Prostate Specific Antigen in the Diagnosis and Treatment of Adenocarcinoma of the Prostate. II. Radiation Treated Patients Thomas A. Stamey, John N. Kabalin, and Michelle Ferrari Thomas A. StameyThomas A. Stamey More articles by this author , John N. KabalinJohn N. Kabalin More articles by this author , and Michelle FerrariMichelle Ferrari More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)41176-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Serum prostate specific antigen was determined (Yang polyclonal radioimmunoassay) in 183 men after radiation therapy for adenocarcinoma of the prostate. A total of 163 men had received 7,000 rad external beam radiotherapy and 20 had been implanted with 125iodine seeds. Only 11 per cent of these 183 patients had undetectable prostate specific antigen levels at a mean interval of 5 years since completion of radiotherapy. Prostate specific antigen levels after radiotherapy were directly related to initial clinical stage and Gleason score before treatment. Multiple prostate specific antigen determinations were performed with time in 124 of 183 patients. During year 1 after radiotherapy prostate specific antigen levels were decreasing in 82 per cent of the patients but only 8 per cent continued to decrease beyond year 1. Of 80 patients observed greater than 1 year after completion of radiotherapy 51 per cent had increasing values and 41 per cent had stable values. Increasing prostate specific antigen values after radiotherapy were correlated with progression to metastastic disease and residual cancer on prostate biopsy. Total serum acid phosphatase levels were poorly related to prostate specific antigen levels, were less effective in discriminating patients with metastatic disease and provided no additional information beyond that provided by prostate specific antigen. © 1989 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByLILJA H, HAESE A, BJÖRK T, FRIEDRICH M, PIIRONEN T, PETTERSSON K, HULAND E and HULAND H (2018) SIGNIFICANCE AND METABOLISM OF COMPLEXED AND NONCOMPLEXED PROSTATE SPECIFIC ANTIGEN FORMS, AND HUMAN GLANDULAR KALLIKREIN 2 IN CLINICALLY LOCALIZED PROSTATE CANCER BEFORE AND AFTER RADICAL PROSTATECTOMYJournal of Urology, VOL. 162, NO. 6, (2029-2035), Online publication date: 1-Dec-1999.BOCHNER B, FIGUEROA A, SKINNER E, LIESKOVSKY G, PETROVICH Z, BOYD S and SKINNER D (2018) SALVAGE RADICAL CYSTOPROSTATECTOMY AND ORTHOTOPIC URINARY DIVERSION FOLLOWING RADIATION FAILUREJournal of Urology, VOL. 160, NO. 1, (29-33), Online publication date: 1-Jul-1998.Noldus J and Stamey T (2018) Histological Characteristics of Radical Prostatectomy Specimens in Men with a Serum Prostate Specific Antigen of 4 ng./ml. or LessJournal of Urology, VOL. 155, NO. 2, (441-443), Online publication date: 1-Feb-1996.McKenzie M (2018) Re: The Value of Serial Prostate Specific Antigen Determinations 5 Years After RadiotherapyJournal of Urology, VOL. 153, NO. 6, (1953-1954), Online publication date: 1-Jun-1995.Kaye K, Olson D and Payne J (2018) Original Articles: Prostate Cancer: Detailed Preliminary Analysis of Iodine-125 Implantation for Localized Prostate Cancer Using Percutaneous ApproachJournal of Urology, VOL. 153, NO. 3S, (1020-1025), Online publication date: 1-Mar-1995.Rogers E, Ohori M, Kassabian V, Wheeler T and Scardino P (2018) Salvage Radical Prostatectomy: Outcome Measured by Serum Prostate Specific Antigen LevelsJournal of Urology, VOL. 153, NO. 1, (104-110), Online publication date: 1-Jan-1995.Benson M (2018) Editorial: Prostate Specific AntigenJournal of Urology, VOL. 152, NO. 6 Part 1, (2046-2048), Online publication date: 1-Dec-1994.Trapasso J, Dekernion J, Smith R and Dorey F (2018) The Incidence and Significance of Detectable Levels of Serum Prostate Specific Antigen After Radical ProstatectomyJournal of Urology, VOL. 152, NO. 5 Part 2, (1821-1825), Online publication date: 1-Nov-1994.Partin A and Oesterling J (2018) The Clinical Usefulness of Prostate Specific Antigen: Update 1994Journal of Urology, VOL. 152, NO. 5 Part 1, (1358-1368), Online publication date: 1-Nov-1994.Stamey T, Ferrari M and Schmid H (2018) The Value of Serial Prostate Specific Antigen Determinations 5 Years after Radiotherapy: Steeply Increasing Values Characterize 80% of PatientsJournal of Urology, VOL. 150, NO. 6, (1856-1859), Online publication date: 1-Dec-1993.Brendler C (2018) Editorial: Prostate CancerJournal of Urology, VOL. 150, NO. 6, (1865-1866), Online publication date: 1-Dec-1993.Kaplan I, Cox R and Bagshaw M (2018) Prostate Specific Antigen after External Beam Radiotherapy for Prostatic Cancer: FollowupJournal of Urology, VOL. 149, NO. 3, (519-522), Online publication date: 1-Mar-1993.Yuan J, Coplen D, Petros J, Figenshau R, Ratliff T, Smith D and Catalona W (2018) Effects of Rectal Examination, Prostatic Massage, Ultrasonography and Needle Biopsy on Serum Prostate Specific Antigen LevelsJournal of Urology, VOL. 147, NO. 3 Part 2, (810-814), Online publication date: 1-Mar-1992.Benson M, Seong Whang I, Olsson C, Mcmahon D and Cooner W (2018) The Use of Prostate Specific Antigen Density to Enhance the Predictive Value of Intermediate Levels of Serum Prostate Specific AntigenJournal of Urology, VOL. 147, NO. 3 Part 2, (817-821), Online publication date: 1-Mar-1992.Brawer M, Chetner M, Beatie J, Buchner D, Vessella R and Lange P (2018) Screening for Prostatic Carcinoma with Prostate Specific AntigenJournal of Urology, VOL. 147, NO. 3 Part 2, (841-845), Online publication date: 1-Mar-1992.Russell K, Dunatov C, Hafermann M, Griffeth J, Polissar L, Pelton J, Cole S, Taylor E, Wiens L, Koh W, Austin-Seymour M, Griffin B, Russell A, Laramore G and Griffin T (2018) Prostate Specific Antigen in the Management of Patients with Localized Adenocarcinoma of the Prostate Treated with Primary Radiation TherapyJournal of Urology, VOL. 146, NO. 4, (1046-1052), Online publication date: 1-Oct-1991.Gottesman J, Tesh D and Weissman W (2018) Failure of Open Radioactive 125Iodine Implantation to Control Localized Prostate Cancer: A Study of 41 PatientsJournal of Urology, VOL. 146, NO. 5, (1317-1319), Online publication date: 1-Nov-1991.Oesterling J (2018) Prostate Specific Antigen: A Critical Assessment of the Most Useful Tumor Marker for Adenocarcinoma of the ProstateJournal of Urology, VOL. 145, NO. 5, (907-923), Online publication date: 1-May-1991.Schellhammer P, Schlossberg S, El-Mahdi A, Wright G and Brassil D (2018) Prostate Specific Antigen Levels after Definitive Irradiation for Carcinoma of the ProstateJournal of Urology, VOL. 145, NO. 5, (1008-1010), Online publication date: 1-May-1991.Stamey T (2018) Editorial CommentsJournal of Urology, VOL. 145, NO. 5, (1010-1011), Online publication date: 1-May-1991.Lange P, Lightner D, Medini E, Reddy P and Vessella R (2018) The Effect of Radiation Therapy after Radical Prostatectomy in Patients with Elevated Prostate Specific Antigen LevelsJournal of Urology, VOL. 144, NO. 4, (927-932), Online publication date: 1-Oct-1990.Lindner A, Siegel Y and Korczak D (2018) Serum Prostate Specific Antigen Levels During Hyperthermia Treatment of Benign Prostatic HyperplasiaJournal of Urology, VOL. 144, NO. 6, (1388-1389), Online publication date: 1-Dec-1990.Arai Y, Yoshiki T and Yoshida O (2018) Prognostic Significance of Prostate Specific Antigen in Endocrine Treatment for Prostatic CancerJournal of Urology, VOL. 144, NO. 6, (1415-1419), Online publication date: 1-Dec-1990.Graves H, Kamarei M and Stamey T (2018) Identity of Prostate Specific Antigen and the Semen Protein P30 Purified by a Rapid Chromatography TechniqueJournal of Urology, VOL. 144, NO. 6, (1510-1515), Online publication date: 1-Dec-1990.Graves H, Wehner N and Stamey T (2018) Comparison of a Polyclonal and Monoclonal Immunoassay for PSA: Need for an International Antigen StandardJournal of Urology, VOL. 144, NO. 6, (1516-1522), Online publication date: 1-Dec-1990.Catalona W (2018) Editorial CommentsJournal of Urology, VOL. 144, NO. 5, (1175-1175), Online publication date: 1-Nov-1990.Kabalin J, Hodge K, McNeal J, Freiha F and Stamey T (2018) Identification of Residual Cancer in the Prostate Following Radiation Therapy: Role of Transrectal Ultrasound Guided Biopsy and Prostate Specific AntigenJournal of Urology, VOL. 142, NO. 2 Part 1, (326-331), Online publication date: 1-Aug-1989.Stamey T, Kabalin J, Ferrari M and Yang N (2018) Prostate Specific Antigen in the Diagnosis and Treatment of Adenocarcinoma of the Prostate. IV. Anti-Androgen Treated PatientsJournal of Urology, VOL. 141, NO. 5, (1088-1090), Online publication date: 1-May-1989. Volume 141Issue 5May 1989Page: 1084-1087 Advertisement Copyright & Permissions© 1989 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Thomas A. Stamey More articles by this author John N. Kabalin More articles by this author Michelle Ferrari More articles by this author Expand All Advertisement Loading ...