gebhart/patrepeval huggingface dataset:
General one-dimensional treatment of the layered piezoelectric resonator with two electrodes (1987)

A general transfer matrix description of arbitrarily oriented layered piezoelectric structures is presented. Except for the restriction to two electrodes, it is the most general one-dimensional treatment possible. The description is derived as an exact solution of the fundamental differential equations and the boundary conditions at the terminating surfaces and at the electrical port. It allows the calculation of the electrical admittance appearing between the electrodes for any frequency, as well as the determination of the entire resonance frequency spectrum using only simple matrix multiplications. It covers the general case of multimode excitations and its coupling results. Thus it is not restricted to a single displacement direction and can be used for the rigorous analysis of layered structures containing, e.g., doubly rotated Y-cut quartz crystals.
Smart Wireless Temperature Measurement System Based on Embedded Systems (2008)

For adapting to the modern industrial system,a temperature wireless measurement system based on the ARM7 processor core S3C44B0 and real-time embedded operating system μC/OS-Ⅱ,is designed,This system collects and transmit.On-the-spot temperature data measured in various environments to the monitoring center through GPRS network,thus realizing wireless collection and transmission of temperature data and meeting the requirement by modern industry for real-time monitoring of on-the-spot temperature.
Characterization of the lipid acyl hydrolase activity of the major potato (Solanum tuberosum) tuber protein, patatin, by cloning and abundant expression in a baculovirus vector (1988)

Patatin is a family of glycoproteins that accounts for 30-40% of the total soluble protein in potato (Solanum tuberosum) tubers. This protein has been reported not only to serve as a storage protein, but also to exhibit enzymic activity. By using a baculovirus system to express protein from the patatin cDNA clone pGM01, it was unambiguously shown that the patatin coded by this DNA has lipid acyl hydrolase and acyltransferase activities. The enzyme is active with phospholipids, monoacylglycerols and p-nitrophenyl esters, moderately active with galactolipids, but is apparently inactive with di- and tri-acylglycerols.
A flexible array format for large‐scale, rapid blood group DNA typing (2005)

It has been shown that microarray technology can be used to type DNA and detect new alleles in donor cohorts.
The Merck index (1998)

Presents over 10,000 monographs which detail chemicals, drugs and biologicals, and describe a single substance or small group of related compounds. This CD-ROM provides the tools to draw structures and then search for them. Users are able to access the data they need quickly with a choice of search options: text search, structure search, and sub-structure search. Text searching is possible for every field of the database: chemical, common, generic and brand names; molecular weights and formulae; physical and toxicity data; and citations to the scientific and patent literature. New with this release are organic name reactions available as a fully text searchable file, and 100 new monographs detailing the latest new drugs and compounds of recent interest. This CD-ROM should be of interest to medicinal chemists, pharmaceutical chemists, biochemists, environmentalists, medical practitioners, natural product chemists, biologists, food scientists, pharmacologists, clinical chemists, organic chemists, inorganic chemists, and information professionals.
Cone-Beam Reconstruction Using Filtered Backprojection (2001)

The art of medical computed tomography is constantly evolving and the last years have seen new ground breaking systems with multi-row detectors. These tomographs are able to increase both scanning speed and image quality compared to the single-row systems more commonly found in hospitals today. This thesis deals with three-dimensional image reconstruction algorithms to be used in future generations of tomographs with even more detector rows than found in currentmultirow systems. The first practical algorithm for three-dimensional reconstruction from conebeamprojections acquired from a circular source trajectory is the FDKmethod. We present a novel version of this algorithm that produces images of higher quality. We also formulate a version of the FDK method that performs the backprojection in O(N3 logN) steps instead of the O(N4) steps traditionally required. An efficient way to acquire volumetric patient data is to use a helical source trajectory together with a multi-row detector. We present an overview of existing reconstruction algorithms for this geometry. We also present a new family of algorithms, the PI methods, which seem to surpass other proposals in simplicity while delivering images of high quality. The detector used in the PI methods is limited to a window that exactly fits the cylindrical section between two consecutive turns of the helical source path. A rebinning to oblique parallel beams yields a geometry with many attractive properties. The key property behind the simplicity of the PI methods is that each object point to be reconstructed is illuminated by the source during a rotation of exactly half a turn. This allows for fast and simple reconstruction.
Wide distribution of homologs of Escherichia coli Kdp K+-ATPase among gram-negative bacteria (1989)

We used Southern blotting to screen a variety of bacterial genes for homology to the kdp genes of Escherichia coli, genes that encode an ATP-driven K+ transport system. We found that most enterobacteria have sequences homologous to those of the three kdp structural genes and the kdpD regulatory gene. A number of distantly related species, including some cyanobacteria, have sequences homologous to those of the structural genes but not the regulatory gene. In all cases only a single region of homology was found. These results suggest that ATP-driven transport systems similar to the Kdp system in structure and regulation are found in many enteric organisms. In other gram-negative organisms, the ATPase is more divergent, retaining good homology at the DNA level only to the highly conserved phosphorylated subunit of the ATPase.
Towards a visual modeling approach to designing microelectromechanical system transducers (1999)

In this paper, we address initial design capture and system conceptualization of microelectromechanical system transducers based on visual modeling and design. Visual modeling frames the task of generating hardware description language (analog and digital) component models in a manner similar to the task of generating software programming language applications. A structured topological design strategy is employed, whereby microelectromechanical foundry cell libraries are utilized to facilitate the design process of exploring candidate cells (topologies), varying key aspects of the transduction for each topology, and determining which topology best satisfies design requirements. Coupled-energy microelectromechanical system characterizations at a circuit level of abstraction are presented that are based on branch constitutive relations and an overall system of simultaneous differential and algebraic equations. The resulting design methodology is called visual integrated-microelectromechanical VHDL-AMS interactive design (VHDL-AMS is visual hardware design language for analog and mixed signal).
Hydrolysis chemistry of the metallocene dichlorides M(.eta.5-C5H5)2Cl2, M = titanium, vanadium, or zirconium. Aqueous kinetics, equilibria, and mechanistic implications for a new class of antitumor agents (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrolysis chemistry of the metallocene dichlorides M(.eta.5-C5H5)2Cl2, M = titanium, vanadium, or zirconium. Aqueous kinetics, equilibria, and mechanistic implications for a new class of antitumor agentsJeffrey H. Toney and Tobin J. MarksCite this: J. Am. Chem. Soc. 1985, 107, 4, 947–953Publication Date (Print):February 1, 1985Publication History Published online1 May 2002Published inissue 1 February 1985https://doi.org/10.1021/ja00290a033RIGHTS & PERMISSIONSArticle Views1000Altmetric-Citations271LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (956 KB) Get e-Alertsclose Get e-Alerts
Tomorrow's surgery: Micromotors and microrobots for minimally invasive procedures (1998)

Surgical procedures have changed radically over the last few years due to the arrival of new technology. What will technology bring us in the future? This paper examines a few of the forces whose timing is causing new ideas to congeal from the fields of artificial intelligence, robotics, micro-machining and smart materials. Intelligence systems for autonomous mobile robots can now enable simple, insect level, behaviors in small amounts of silicon. These software break-throughs, coupled with new techniques for micro-fabrication of miniature sensors and actuators from both silicon and ferroelectric families of materials, offer glimpses of the future where robots will be small, cheap and, potentially, very useful to surgeons. In this paper we relate our recent work with small mobile robots and in fabricating piezoelectric micromotors, in an effort to develop actuator technologies where brawn matches the scale of the brain. We discuss our experiments with thin film piezoelectric ultrasonic motors 2 mm in diameter and larger versions, machined from bulk ceramic, 8 mm in diameter. We also sketch possible applications in the surgical field and discuss larger-scale prototypes for intestine crawlers.
A Comparative Study of Two Regimens of Combination Chemotherapy in Acute Leukemia (1958)

Abstract A comparative clinical trial of two regimens of combination chemotherapy has been accomplished in acute leukemia by four separate medical and pediatric services. Sixty-five patients were allocated at random to one of two treatment programs. Daily administration of methotrexate with daily 6-mercaptopurine has been compared to methotrexate every third day in the same total dose with daily 6-mercaptopurine. No difference in frequency of remission, extent of remission or toxicity was observed between the two groups. Among those patients who attained remission status, however, duration of remission (P = .05-.10) and of survival (P = &lt;.05) was longer for the continuous group. All remissions in children occurred in acute lymphocytic leukemia, whereas all remission in adults were observed in acute myelocytic leukemia. The duration of remissions was somewhat shorter for children with acute lymphocytic leukemia than for adults with acute myelocytic leukemia. The frequency of remission, either partial or complete, was higher in children, however (36 per cent), than in adults (19 per cent), although the confidence limits for each figure overlap. The duration of acute leukemia in previously untreated patients did not influence response to therapy from the two antimetabolite regimens in this study. In patients who had had prior antimetabolite therapy, however, complete remissions were attained less often than in previously untreated patients. The toxic manifestations encountered during the administration of these antimetabolites are described. Seventeen deaths occurred during this study, of which 8 occurred in the first 10 days, presumably from leukemia and not drug toxicity. Five patients died with hypoplastic marrows ascribed to drug toxicity. The toxic manifestations were qualitatively and proportionately the same in patients who attained remission status, and in those patients who failed to remit, but who lived long enough to recognize the onset of remission if it were going to occur. No indication was obtained, therefore, that patients who attained remission were subjected to a greater toxic hazard, in order to achieve the therapeutic benefits observed, than those who did not remit. The median survival of patients who achieved remission was longer (p &lt;.05) than for patients who did not remit. Since the survival time of remitters from relapse to death was almost identical with the survival time of nonremitters from onset of treatment to death, this difference can be accounted for by the time spent in remission and getting to remission. The median survival time from symptomatic onset for all children in this study was 12 months, and for adults, 7 months. The median in children is similar to that reported from other clinics. This is evidence that a comparative therapeutic trial in acute leukemia can be accomplished without recognizable compromise of patient welfare.
Touch and go: tying TonB to transport (2003)

The TonB system of Gram-negative bacteria appears to exist for the purpose of transducing the protonmotive force energy from the cytoplasmic membrane, where it is generated, to the outer membrane, where it is needed for active transport of iron siderophores, vitamin B12 and, in pathogens, iron from host-binding proteins. In this review, we bring the reader up to date on the developments in the field since the authors each wrote reviews in this journal in 1990.
Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells (2002)

Lipoxygenase metabolites of arachidonic acid can act as growth promoting factors for various cancer cell lines. Here we demonstrate that the 5-lipoxygenase inhibitor nordihydroguaiaretic acid potently inhibits anchorage-independent growth of human pancreatic and cervical cancer cells in soft agar and delays growth of pancreatic and cervical tumours established in athymic mice. Furthermore, nordihydroguaiaretic acid induces apoptosis of these cancer cells in vitro and in vivo. Potential mechanisms mediating these effects of nordihydroguaiaretic acid were examined. Nordihydroguaiaretic acid had no inhibitory effect on growth and survival signals such as tyrosine phosphorylation of the epidermal growth factor receptor or basal and growth factor-stimulated activities of extracellular signal-regulated kinase 1/2, p70(s6k) and AKT but selectively inhibited expression of cyclin D1 in the cancer cells. In addition, treatment with nordihydroguaiaretic acid lead to a disruption of the filamentous actin cytoskeleton in human pancreatic and cervical cancer cells which was accompanied by the activation of Jun-NH(2)-terminal kinase and p38(mapk). Similar effects were obtained by treatment of the cancer cells with cytochalasin D. These results suggest that nordihydroguaiaretic acid induces anoikis-like apoptosis as a result of disruption of the actin cytoskeleton in association with the activation of stress activated protein kinases. In conclusion, nordihydroguaiaretic acid could constitute a lead compound in the development of novel therapeutic agents for various types of cancer.
Antimyeloperoxidase-associated proliferative glomerulonephritis: an animal model. (1993)

To develop an animal model for antimyeloperoxidase (MPO)-associated necrotizing crescentic glomerulonephritis (NCGN), we immunized Brown Norway rats with MPO and localized a neutrophil lysosomal enzyme extract, primarily consisting of MPO and elastinolytic enzymes, plus H2O2, the substrate of MPO, to the glomerular basement membrane (GBM). Upon immunization rats developed antibodies and positive skin tests to MPO. After unilateral perfusion of the left kidney with the lysosomal enzyme extract and H2O2, MPO and immunoglobulin (Ig)G localized transiently along the GMB. At the time of maximal inflammation, at 4 and 10 d after perfusion, MPO, IgG, and C3 could not be detected anymore. MPO-immunized rats perfused with the lysosomal enzyme extract and H2O2, in contrast to control-immunized and/or control-perfused rats, developed a proliferative GN characterized by intra- and extracapillary cell proliferation, ruptured Bowman's capsule, periglomerular granulomatous inflammation, and formation of giant cells. Monocytes, polymorphonuclear leukocytes (PMN), and to a far lesser extent T cells were found in the glomeruli. Interstitial infiltrates consisted of monocytes, PMN, and T cells. Granulomatous vasculitis of small vessels was found at 10 d after perfusion. The proliferative NCGN in this rat model closely resembles human anti-MPO-associated pauci-immune NCGN, and enables the study of the pathophysiology of anti-MPO-associated NCGN.
Essential contribution of Ets‐1 to constitutive Pim‐3 expression in human pancreatic cancer cells (2008)

We previously demonstrated that the proto-oncogene Pim-3 with serine/threonine kinase activity was aberrantly expressed in cancer cells but not in the normal cells of the pancreas. In order to elucidate the molecular mechanism underlying aberrant Pim-3 expression in pancreatic cancer cells, we constructed luciferase expression vectors linked to 5'-flanking deletion mutants of the human Pim-3 gene and transfected human pancreatic cancer cells with the resultant vectors. The region up to -264 bp was essential for constitutive Pim-3 gene expression, and the mutation in the Ets-1 binding site (between -216 and -211 bp) reduced luciferase activities. Moreover, Ets-1 mRNA and protein were constitutively expressed together with Pim-3 in human pancreatic cancer cell lines. Chromatin immunoprecipitation assay demonstrated constitutive binding of Ets-1 to the 5'-flanking region of human Pim-3 gene between -249 and -183 bp. Pim-3 promoter activity and its protein expression were induced by transfection with wild type-Ets-1 and were reduced by transfection with dominant negative-Ets-1 or Ets-1 small-interfering RNA (siRNA). Furthermore, dominant negative-Ets-1 and Ets-1 siRNA reduced the amount of Bad phosphorylated at its Ser(112) and induced apoptosis, when they were transfected into human pancreatic cancer cells. Finally, Pim-3 cDNA transfection reversed Ets-1 siRNA-induced increase in apoptosis and decrease in Bad phosphorylation at its Ser(112). These observations would indicate that the transcription factor Ets-1 can induce aberrant Pim-3 expression and subsequently prevent apoptosis in human pancreatic cancer cells.
Evaluation of a new electromagnetic tracking system using a standardized assessment protocol (2006)

This note uses a published protocol to evaluate a newly released 6 degrees of freedom electromagnetic tracking system (Aurora, Northern Digital Inc.). A practice for performance monitoring over time is also proposed. The protocol uses a machined base plate to measure relative error in position and orientation as well as the influence of metallic objects in the operating volume. Positional jitter (E(RMS)) was found to be 0.17 mm +/- 0.19 mm. A relative positional error of 0.25 mm +/- 0.22 mm at 50 mm offsets and 0.97 mm +/- 1.01 mm at 300 mm offsets was found. The mean of the relative rotation error was found to be 0.20 degrees +/- 0.14 degrees with respect to the axial and 0.91 degrees +/- 0.68 degrees for the longitudinal rotation. The most significant distortion caused by metallic objects is caused by 400-series stainless steel. A 9.4 mm maximum error occurred when the rod was closest to the emitter, 10 mm away. The improvement compared to older generations of the Aurora with respect to accuracy is substantial.
THE METABOLISM OF [1,2-3H]17α-METHYLTESTOSTERONE IN HUMAN SUBJECTS (1967)

SUMMARY The metabolism of [1,2- 3 H] 17α-methyltestosterone (MeT) has been studied in adult human subjects, most of whom had cancer of the breast. The rates of disappearance of MeT from plasma and of the appearance of metabolites of MeT in plasma have been measured after intravenous injection of [1,2- 3 H]MeT. In addition, the rate of appearance of [1,2- 3 H]MeT and of metabolites of MeT in urine and in faeces has been measured after intravenous injection of [1,2- 3 H]MeT and in urine after oral administration of the steroid. The results show that MeT is metabolized more slowly than testosterone. Identification of metabolites of MeT which were isolated from the urine of patients to whom this steroid was administered has been attempted. Three compounds, 17α-methyl-5β-androstane-3α,17β-diol (tetrahydro-MeT), 17α-methyl-5α-androstane-3α,17β-diol (allotetrahydro-MeT) and unchanged MeT have been identified, three other compounds have been partially characterized and several others have been isolated. The most abundant metabolites of MeT are hydroxylated compounds reduced in ring A.
Clinical evaluation and reproducibility of the Pastorex Aspergillus antigen latex agglutination test for diagnosing invasive aspergillosis. (1995)

The Pastorex Aspergillus test is too insensitive to diagnose invasive aspergillosis in an early stage, but may contribute to the diagnosis when cultures remain negative and serial samples are obtained. To maintain a good reproducibility, serum samples should be stored at -70 degrees C when the period of storage exceeds six months.
Characterization of cell–cell fusion mediated by herpes simplex virus 2 glycoproteins gB, gD, gH and gL in transfected cells (2000)

The mechanisms by which herpes simplex viruses (HSV) mediate fusion between their envelope and the plasma membrane during entry into cells, and between the plasma membranes of adjacent infected and uninfected cells to form multinucleated giant cells, are poorly understood. Four viral glycoproteins (gB, gD, gH and gL) are required for virus–cell fusion, whereas these plus several others are required for cell–cell fusion (syncytium formation). A better understanding would be aided by the availability of a model system, whereby fusion could be induced with a minimal set of proteins, in the absence of infection. A suitable system has now been developed for HSV-2, using transfected COS7, 293 or HEp-2 cells. Insofar as the minimal set of HSV-2 proteins required to cause cell–cell fusion in this system is gB, gD, gH and gL, it would appear to resemble virus–cell fusion rather than syncytium formation. However, the ability of a mutation in gB to enhance the fusion of both transfected cells and infected cells, while having no effect on virus–cell fusion, points to the opposite conclusion. The differential effects of a panel of anti-HSV antibodies, and of the fusion-inhibitor cyclosporin A, confirm that the fusion of transfected cells shares some properties with virus–cell fusion and others with syncytium formation. It may therefore prove useful for determining how these processes differ, and for testing the hypothesis that some viral proteins prevent membrane fusion until the appropriate point in the virus life-cycle, with other proteins then overcoming this block.