gebhart/patrepeval huggingface dataset:
NDR1 , a Pathogen-Induced Component Required for Arabidopsis Disease Resistance (1997)

Plant disease resistance (R) genes confer an ability to resist infection by pathogens expressing specific corresponding avirulence genes. In Arabidopsis thaliana, resistance to both bacterial and fungal pathogens, mediated by several R gene products, requires the NDR1 gene. Positional cloning was used to isolate NDR1, which encodes a 660-base pair open reading frame. The predicted 219-amino acid sequence suggests that NDR1 may be associated with a membrane. NDR1 expression is induced in response to pathogen challenge and may function to integrate various pathogen recognition signals.
Comparison of a Broad Spectrum Anti-Aging Nutritional Supplement with and without the Addition of a DNA Repair Enhancing Cat's Claw Extract (2002)

Dietary supplements, designed to fortify the antioxidant status of human metabolism, are intended to provide nutritional support against the aging process. The strategy is based on the observation that environmental and metabolic sources of oxidatively generated free radicals damage key macromolecules, such as DNA, that in turn alter physiologic processes, and in turn may contribute to aging and age-related diseases such as cancer, as well as cardiovascular and immunologic disorders. This study investigates whether a commercially available, broad spectrum anti-oxidant formulation containing 12 vitamins, 8 minerals, 2 agents to provide "blood sugar/insulin support," 3 botanical antioxidants, one methylating factor, two "fat metabolizers," an "absorption enhancer," a "brain enhancer," a "whole food" ingredient, 2 "cellular energizers," a nucleotide precursor, 2 amino acids, a fatty acid complex, a "probiotic complex," and a digestive enzyme (formula one) could be improved through inclusion of an ingredient that enhances DNA repair (C-Med-100). The two formulations were compared using four intermediate endpoint biomarkers: 8-OH guanine DNA adducts, serum thiols, and Interleukins 1a and 1. Whereas both were shown to be effective at reducing DNA damage, the second, more inclusive formulation appeared to be more effective.
3D Printing Optical Engine for Controlling Material Microstructure (2016)

Controlling the cooling rate of alloy during melting and resolidification is the most commonly used method for varying the material microstructure and consequently the resuling property. However, the cooling rate of a selective laser melting (SLM) production is restricted by a preset optimal parameter of a good dense product. The head room for locally manipulating material property in a process is marginal. In this study, we invent an Optical Engine for locally controlling material microstructure in a SLM process. It develops an invovative method to control and adjust thermal history of the solidification process to gain desired material microstucture and consequently drastically improving the quality. Process parameters selected locally for specific materials requirement according to designed characteristics by using thermal dynamic principles of solidification process. It utilize a technique of complex laser beam shape of adaptive irradiation profile to permit local control of material characteristics as desired. This technology could be useful for industrial application of medical implant, aerospace and automobile industries.
Magnesia-Supported Tetrairidium Clusters Derived from [Ir4(CO)12] (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMagnesia-Supported Tetrairidium Clusters Derived from [Ir4(CO)12]N. D. Triantafillou and B. C. GatesCite this: J. Phys. Chem. 1994, 98, 34, 8431–8441Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/j100085a026https://doi.org/10.1021/j100085a026research-articleACS PublicationsRequest reuse permissionsArticle Views143Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Cellulase Inhibitor in Grape Leaves (1960)

1. A water-soluble substance in grape leaves which inhibits the enzymatic hydrolysis of soluble cellulose is reported. The mature leaves of six grape varieties of the Muscadine group (Vitis rotundifolia Michx.) were found to be good sources of the inhibitor. 2. The reduction in cellulase activity obtained was directly related to the concentration of inhibitor used. Cucumber-flower cellulase was more sensitive to inhibition by the grape-leaf substance than were the four commercial cellulases studied. 3. The grape-leaf extracts containing the inhibiting substance were stable to heat, to weak acid and alkali, and to such protein precipitating agents as trichloroacetic acid. The inhibitor was non-dialyzable through cellophane or collodion membranes against water or weakly buffered solutions (3 days). 4. The cellulase-inhibiting substance is not related in structure to carbohydrates or proteins and appears to be a high-molecular-weight organic constituent.
Albumin binding proteins are highly expressed in actively proliferating fetal and adult tissues. (1990)

The expression of albumin binding proteins (ABP, 31 and 18 kDa peptides) in various organs as a function of their ontogenic development was investigated in fetuses (20 days old), neonates (1 day old) and adult rabbits. At each of these stages, tissue extracts of brain, lung, thymus, heart, skeletal muscle and liver as well as whole embryos (11 days old) were examined by ligand blotting and quantitative immunoblot assays. Blots were either incubated with [125I]albumin followed by autoradiography and radioassay or exposed to a radioiodinated antibody raised against affinity-isolated 31 kDa peptide. Anti-31 kDa IgG cross-reacted with both 31 and 18 kDa peptides. Both methods used revealed that ABP are well expressed in embryos and in all fetal organs investigated. By comparison, in neonates, the ABP expression was diminished (by approximately 2-fold) in brain, heart and skeletal muscle. These changes were even more pronounced in the adult rabbit brain, heart, skeletal muscle and liver; no significant modification was detected in the lung. Prompted by these results, which inferred a high level of ABP in actively proliferating/differentiating tissues, we checked for the presence of ABP in other adult cells and tissues. In bone marrow cells, thymocytes and splenocytes, the 31 and 18 kDa peptides represented the major sodium dodecyl sulfate-urea extracted proteins, whereas in mature circulating white blood cells they were moderately expressed. The results indicate that ABP 1) are present early in embryogenesis, 2) are particularly well expressed in organs (fetal or adult) and cells characterized by active proliferation and differentiation, and 3) are not tissue specific.(ABSTRACT TRUNCATED AT 250 WORDS)
v-maf, a viral oncogene that encodes a "leucine zipper" motif. (1989)

We have molecularly cloned the provirus of the avian musculoaponeurotic fibrosarcoma virus AS42. Nucleotide sequence analysis of a biologically active clone of AS42 showed that this virus encodes a viral oncogene, maf. The deduced amino acid sequence of the v-maf gene product contains a "leucine zipper" motif similar to that found in a number of DNA binding proteins, including the gene products of the fos, jun, and myc oncogenes. However, unlike these oncogenes, the cellular maf gene was not transcriptionally activated by growth stimulation of cultured cells.
Serotonin and Migraine (1990)

Migraine has long been considered as a "vascular headache" but clearly neurological mechanisms are involved. The pathophysiology appears to somehow involve serotonin, both peripherally and centrally, but its involvement may be just epiphenomenal. Adding to the enigma it is apparent that many of the presently available drugs for the treatment of migraine interact in one way or another with serotonin receptors. However, they tend to have a number of other unrelated actions and they are only of limited clinical value. Interestingly a promising new drug for the treatment of the acute attack, sumatriptan, has a very selective action as an agonist at a specific 5-HT1-like receptor sub-type, mediating vasoconstriction, which is localized on cranial blood vessels. Its action may, or may not, be independent of any involvement of serotonin in the genesis of migraine. Hopefully though, current attempts to determine sumatriptan's mechanism of action will shed further light on the pathology of migraine itself and the putative involvement of serotonin.
Development of Sandwich HPLC Microcolumns for Analyte Adsorption on the Millisecond Time Scale (2001)

A new class of columns is reported that uses only microgram quantities of active support and that provides for the retention of biological compounds and other analytes on the millisecond time scale. This was accomplished by packing standard HPLC supports into layers as small as 60 microm in length and using only 90 microg of support material. This provided columns with effective residence times in the millisecond time range when routine HPLC flow rates and pressures were used. The retention of analytes by such columns was examined under both adsorption- and diffusion-limited conditions. The RPLC adsorption of hemoglobin (a system with diffusion-limited retention) was found to give 95% binding in as little as 4 ms. The adsorption of fluorescein by an anti-fluorescein antibody column (an adsorption-limited system) gave 95% retention in 100-120 ms. One application examined for these columns was their use in a chromatographic-based competitive binding immunoassay. This used bovine serum albumin (BSA) as the model analyte, and fluorescein-labeled BSA was used for detection. The resulting approach had a contact time of 180 ms between the sample and an anti-BSA immunoaffinity microcolumn and provided a signal within 5-25 s after sample injection. The columns developed in this work should also be useful in other situations that involve a small amount of a stationary phase or that require short column residence times.
Altered Antigen Expression Predicts Outcome in Squamous Cell Carcinoma of the Head and Neck (1990)

Monoclonal antibody UM-A9 identifies an antigen found on the basal surface of epithelial cells and expressed on all of the squamous cell carcinomas (SCC) that we have tested. In a previous study, we showed that cell lines from metastatic or recurrent SCC exhibit stronger expression of the A9 cell membrane antigen than cell lines from the primary tumor of the same donors, suggesting that this marker is associated with tumor progression. Loss of expression in tumor tissue of normal A, B, and H (ABH) blood group antigens has also been linked to clinical behavior in some epithelial cancers. To determine the prognostic significance of these antigen markers, we prospectively evaluated tissue specimens for expression of these markers in a group of 82 consecutive, previously untreated patients with SCC of the head and neck. Three patterns corresponding to strong (pattern 1), intermediate (pattern 2), or weak (pattern 3) A9 antigen expression were observed. Fifty-eight percent of the patients whose tumors had pattern 1 A9 antigen expression and 78% of the patients with loss of blood group antigen had early relapse, compared with only 34% of those with A9 antigen pattern 2 or 3 (P = .042) and 37% of those whose tumors expressed the mature ABH blood group antigen (P = .012). The combination of A9 pattern and ABH blood group antigen expression in tumor tissue was the variable most strongly associated with duration of disease-free survival, even after adjustment for the traditional prognostic factors of tumor site, stage, and TNM classification. Loss of blood group was the most significant single variable associated with early recurrence, but among patients whose tumors retained ABH blood group antigen expression, the A9 pattern distinguished good and poor prognostic groups. To our knowledge, our study is the first to demonstrate that differences in blood group antigen expression are significantly correlated with disease-free survival in SCC of the head and neck. We have initiated a study (a) to determine the relationship of the A9 antigen and the blood group antigens with clinical response of the tumors and (b) to determine whether these markers should be used as prognostic indicators.
Membrane voltage initiates Ca 2+ waves and potentiates Ca 2+ increases with abscisic acid in stomatal guard cells (1998)

In higher plants changes and oscillations in cytosolic free Ca2+ concentration ([Ca2+]i) are central to hormonal physiology, including that of abscisic acid (ABA), which signals conditions of water stress and alters ion channel activities in guard cells of higher-plant leaves. Such changes in [Ca2+]i are thought to encode for cellular responses to different stimuli, but their origins and functions are poorly understood. Because transients and oscillations in membrane voltage also occur in guard cells and are elicited by hormones, including ABA, we suspected a coupling of [Ca2+]i to voltage and its interaction with ABA. We recorded [Ca2+]i by Fura2 fluorescence ratio imaging and photometry while bringing membrane voltage under experimental control with a two-electrode voltage clamp in intact Vicia guard cells. Free-running oscillations between voltages near -50 mV and -200 mV were associated with oscillations in [Ca2+]i, and, under voltage clamp, equivalent membrane hyperpolarizations caused [Ca2+]i to increase, often in excess of 1 microM, from resting values near 100 nM. Image analysis showed that the voltage stimulus evoked a wave of high [Ca2+]i that spread centripetally from the peripheral cytoplasm within 5-10 s and relaxed over 40-60 s thereafter. The [Ca2+]i increases showed a voltage threshold near -120 mV and were sensitive to external Ca2+ concentration. Substituting Mn2+ for Ca2+ to quench Fura2 fluorescence showed that membrane hyperpolarization triggered a divalent influx. ABA affected the voltage threshold for the [Ca2+]i rise, its amplitude, and its duration. In turn, membrane voltage determined the ability of ABA to raise [Ca2+]i. These results demonstrate a capacity for voltage to evoke [Ca2+]i increases, they point to a dual interaction with ABA in triggering and propagating [Ca2+]i increases, and they implicate a role for voltage in "conditioning" [Ca2+]i signals that regulate ion channels for stomatal function.
Guidelines for nasal provocations with aspects on nasal patency, airflow, and airflow resistance. International Committee on Objective Assessment of the Nasal Airways, International Rhinologic Society. (2000)

Under the auspices of the International Rhinologic Society (IRS) there is an 'International Committee on Objective Assessment of the Nasal Airways'. In 1984 Rhinology published the Committee's recommendations regarding rhinomanometry (Clement, 1984). During the last Congresses of the European Rhinologic Society (ERS) a subcommittee within that committee has discussed nasal provocations and the value of measuring nasal patency, airflow and airflow resistance to evaluate such provocations. The following is an effort to a consensus of indications and techniques for nasal provocation and to a critical analysis of methods to measure the effects. Only the most known methods will be discussed, i.e. acoustic rhinometry, rhinostereometry, nasal peak airflow and rhinomanometry with its different techniques. For graded responses after provocations the use of such methods is of clinical value only in combination with scores from symptoms such as sneezes and secretion, as allergic rhinitis symptoms consist of obstruction, sneezing, itching and concomitant symptoms of the neighbouring organs. For research all methods can be recommended to be used and their respective value is depending on the specific scientific purposes.
Fences and Synchronisation Idioms in Weak Memory Models (2009)

We present an axiomatic framework, implemented in the Coq proof assistant, to define weak memory models in terms of several parameters: local reorderings of reads and writes, and visibility of inter and intra processor communications through memory, including full store atomicity relaxation. Thereby, we give a formal hierarchy of weak memory models, in which we provide a formal study of what should be the action and placement of fences to restore a given model such as SC from a weaker one. Finally, we provide formal requirements for abstract locks that guarantee SC semantics to data race free programs, and show that a particular implementation of locks matches these requirements.
High performance compilers for parallel computing (1996)

1. High Performance Systems. An Example Program: Matrix Multiplication. Structure of a Compiler. 2. Programming Language Features. Languages for High Performance. Sequential and Parallel Loops. Roundoff Error. 3. Basic Graph Concepts. Sets, Tuples, Logic. Graphs. Control Dependence. 4. Review of Linear Algebra. Real Vectors and Matrices. Integer Matrices and Lattices. Linear System of Equations. System of Integer Equations. Systems of Linear Inequalities. Systems of Integer Linear Inequalities. Extreme Values of Affine Functions. 5. Data Dependence. Data Dependence in Loops. Data Dependence in Conditionals. Data Dependence in Parallel Loops. Program Dependence Graph. 6. Scalar Analysis with Factored Use-Def Chains. Constructing Factored Use-Def Chains. FUD Chains for Arrays. Finding All Reaching Definitions. Implicit References in FUD Chains. InductionVariables Using FUD Chains. Constant Propagation with FUD Chains. Data Dependence for Scalars. 7. Data Dependence Analysis for Arrays. Building the Dependence System. Dependence System Solvers. General Solver. Summary of Solvers. Complications. Run-time Dependence Testing. 8. Other Dependence Problems. Array Region Analysis. Pointer Analysis. I/O Dependence. Procedure Calls. Interprocedural Analysis. 9. Loop Restructuring. Simpile Transformations. Loop Fusion. Loop Fission. Loop Reversal. Loop Interchanging. Loop Skewing. Linear Loop Transformations. Strip-Mining. Loop Tiling. Other Loop Transformations. Interprocedural Transformations. 10. Optimizing for Locality. Single Reference to Each Array. Multiple References. General Tiling. Fission and Fusion for Locality. 11. Concurrency Analysis. Code for Concurrent Loops. Concurrency from Sequential Loops. Concurrency from Parallel Loops. Nested Loops. Roundoff Error. Exceptions and Debuggers. 12. Vector Analysis. Vector Code. Vector Code from Sequential Loops. Vector Code from Forall Loops. Nested Loops. Roundoff Error, Exceptions, and Debuggers. Multivector Computers. 13. Message-Passing Machines. SIMD Machines. MIMD Machines. Data Layout. Parallel Code for Array Assignment. Remote Data Access. Automatic Data Layout. Multiple Array Assignments. Other Topics. 14. Scalable Shared-Memory Machines. Global Cache Coherence. Local Cache Coherence. Latency Tolerant Machines. Glossary. References. Author Index. Index. 0805327304T04062001
Two-Dimensional Arrays of Self-Assembled Gold and Sulfur-Containing Fullerene Nanoparticles (2002)

Two-dimensional (2D) arrays of gold nanoparticles with sulfur-containing fullerene nanoparticles were self-assembled through the formation of Au−S covalent bonds. Disulfide functional groups were introduced into the C60 molecule by reacting propyl 2-aminoethyl disulfide with C60. The 2D arrays were formed at the interface of the aqueous phase of gold particles and organic phase of fullerene particles as a blue transparent film. Transmission electronic microscope images showed that the fullerene spacing between adjacent Au (∼10 nm) particles was about 2.1 ± 0.4 nm, which was consistent with the result of 2.18 nm by molecular molding calculations (MM+). The UV−visible spectrum of this film showed a red shift and increased bandwidth due to the small spacing between gold nanoparticles. The arrays were deposited on the top of pairs of gold electrodes to form 2D colloidal single electron devices. The electrode pairs were made by electron beam lithographic techniques, and the separation between tips of the two electrodes in a pair was about 100 nm. Electron transport measurements at low temperatures exhibited Coulomb blockade type current−voltage characteristics due to the charge effects. The assembled arrays have potential applications as nanoelectronics.
131 W 220 fs fiber laser system (2005)

We report on an ytterbium-doped photonic-crystal-fiber-based chirped-pulse amplification system delivering 131 W average power 220 fs pulses at 1040 nm center wavelength in a diffraction-limited beam. The pulse repetition rate is 73 MHz, corresponding to a pulse energy of 1.8 microJ and a peak power as high as 8.2 MW.
Study on the Synthesis, Characterization and Bioactivities of 3-Methyl-9’-fluorenespiro-5-hydantoin (2016)

This work describes a method for synthesis, as well as in vitro antiproliferative and antibacterial investigation of 3-methyl-9'-fluorenespiro-5-hydantoin. The structure of the substituted fluorenylspirohydantoin derivative was verified by UV-Vis, FT-IR, Raman, (1)H-NMR and (13)C-NMR spectroscopy, and by using a combination of 2D NMR experiments, which included (1)H-(1)H COSY, HMQC and HMBC sequences. The geometry of the compound was optimized by the B3LYP density functional with 6-31G(d) basis set and the (1)H and (13)C NMR spectra were predicted with the HF/6-31G(d) calculations at the optimized geometry. The anticancer activity of the 3-methyl-9'-fluorenespiro-5-hydantoin was determined in suspension cell lines originating from tumors in humans (WERI-Rb-1). The cytotoxic effect was evaluated by WST-assay (Roche Applied Science). The antimicrobial effect of the compound against Gram-negative, Gram-positive bacteria and the yeast Candida albicans was investigated.
Progress in Technology of Flue Gas Desulfurization for Thermal Power Plants (2003)

Progress in technology of flue gas desulfurization at home and abroad is analyzed. The flue gas desulfurization project in China from thermal power plants and industrial boilers by using foreign technology and equipment is introduced.