gebhart/patrepeval huggingface dataset:
Development of a Novel Cam-based Infinitely Variable Transmission (2009)

An infinitely variable transmission (IVT) is a transmission that can smoothly and continuously vary the speed ratio between an input and output from zero to some other positive or negative ratio; they are a subset of continuously variable transmissions (CVTs), which themselves do not have the ability to produce a zero gear ratio. In this thesis, the operation, analysis, and development of a novel, highly configurable, Cam-based Infinitely Variable Transmission of the ratcheting drive type is presented. There are several categories of CVTs in existence today, including traction, belt, and ratcheting types. Drives of these types, their attributes, and associated design challenges are discussed to frame the development of the Cam-based IVT. The operation of this transmission is kinematically similar to a planetary gearset, and therefore, its operation is described with that in mind including a description of the six major components of the transmission, those being the cam, followers, carriers, planet gears, sun gears, and one way clutches. The kinematic equation describing its motion is derived based on the similarities it shares with a planetary gearset. Additionally, the equations for the cam design are developed here as the operation of the CVT is highly dependent on the shape of the cam. There are six simple inversions of this device and each inversion has special characteristics and limitations, for example, the available gear range. A method was developed to select the most suitable inversion, gearing, and follower velocity for a given application. The contact stress between the rollers and cam is the limiting stress within the transmission. A parametric study is used to quantify the relationship between this stress and the transmission parameters. Based off those results, two optimization strategies and their results are discussed. The first is an iterative brute force type numerical search and the second is a genetic algorithm. The optimization results are shown to be similar and successfully reduced the contact stress by 40%. To further improve the transmission performance, several mechanisms were developed for this unique transmission. These include a compact and lightweight differential mechanism based on a cord and pulley system to reduce the contact force on the rollers. In addition, a unique external/inverted cam topology was developed to improve the contact geometry between the rollers and said cam. A prototype was built based on both the optimization strategies and these mechanisms and is described within. Finally, a Prony brake dynamometer with cradled motor was constructed to test the transmission; the results of those tests show the Cam-based IVT to be 93% efficient at low input torque levels.
Making high-affinity T-cell receptors: a new class of targeted therapeutics. (2006)

The last two decades have seen the development of an expanding array of monoclonal antibodies, which are proving to be effective treatments for both cancer and autoimmune disease. A related protein, the human T-cell receptor (TCR), is able to access a new range of targets for which antibodies are unsuitable, and is being developed as a new class of protein therapeutics. Similar to antibodies, TCRs have a specific target and therefore a limited potential for side effects; however, a possible drawback with these receptors is that their natural affinity is low. This problem has recently been overcome using phage display to increase TCR affinity up to a million-fold.
Stereo-Assist: Top-down stereo for driver assistance systems (2010)

This paper presents a top-down approach to stereo for use in driver assistance systems. We introduce an asymmetric configuration where monocular object detection and range estimation is performed in the primary camera and then that image patch is aligned and matched in the secondary camera. The stereo distance measure from the matching assists in target verification and improved distance measurements. This approach, Stereo-Assist, shows significant advantages over the classical bottom-up stereo approach which relies on first computing a dense depth map and then using the depth map for object detection. The new approach can provide increased object detection range, reduced computational load, greater flexibility in camera configurations (we are no longer limited to side-by-side stereo configurations), greater robustness to obstructions in part of the image and mixed camera modalities FIR/VIS can be used. We show results with two novel configurations and illustrate how monocular object detection allows for simple online calibration of the stereo rig.
Prophylaxis of graft-versus-host disease by administration of the murine anti-IL-2 receptor antibody 2A3. (1991)

The efficacy of murine monoclonal IgG1 antibody 2A3 specific for the 55 kD chain of the human IL-2 receptor (CD25) was evaluated for prophylaxis of acute GVHD in patients with advanced leukemia transplanted with unmodified bone marrow from related HLA-haploidentical donors incompatible for two or three HLA loci of the nonshared haplotype. As GVHD prophylaxis, 36 patients (control) received standard cyclosporine and methotrexate (C + M) whereas 11 patients (study) received C + M plus antibody 2A3, 1.0 mg/kg on day -1, and 0.5 mg/kg daily from day 0 through day +19. Antibody administration was not associated with appreciable toxicity and did not adversely affect engraftment. During treatment, circulating CD25+ cells appeared saturated by the infused antibody. Patients receiving antibody 2A3 tolerated more cyclosporine than controls (p less than 0.001) with lower increase of serum creatinine (p less than 0.05) during the first month. Seven of 10 (70%) evaluable study patients developed acute GVHD of grade II-IV with onset at a median of 20 days compared to 27 of 31 (87%) control patients with onset at a median of 13 days (p = 0.11). Trough serum levels of antibody 2A3 ranged from 7.2 to 68.8 mg/l, and lower values correlated with occurrence of acute GVHD. A human anti-mouse immunoglobulin antibody response was detected in four patients but was not associated with lower levels of antibody 2A3 in the serum. Two study patients and two controls have survived more than 1 year (p = 0.92). These findings suggest that administration of antibody 2A3 suppressed and delayed activation of alloantigen-specific T cells but did not result in their elimination.
Automatic Processing of Document Annotations (1998)

A common authoring technique involves making annotations on a printed draft and then typing the corrections into a computer at a later date. In this paper, we describe a system that goes some way towards automating this process. The author simply passes the annotated documents through a sheetfeed scanner and then brings up the electronic document in a text editor. The system then works out where the annotated words are and allows the author to skip from one annotation to the next at the touch of a key. At the heart of the system lies a procedure for reliably establishing correspondences between printed words and their electronic counterparts, without performing optical character recognition. This procedure might have interesting applications in document database retrieval, since it allows an electronic document to be indexed by a printed version of itself.
Defect structure in selectively grown GaN films with low threading dislocation density (1997)

We have characterized by transmission electron microscopy (TEM) defect structures in GaN films grown selectively in hydride vapor-phase epitaxy (HVPE). In this experiment, growth was achieved on SiO2-stripe-patterned GaN layers that had been grown by metalorganic vapor-phase epitaxy (MOVPE) on sapphire substrates. Cross-sectional TEM revealed unambiguously that most of the dislocations, which originated from threading dislocations vertically aligned in the MOVPE-grown layer, propagated laterally around the SiO2 mask in the HVPE-grown film before the film thickness amounted to about 5 μm. This change of the propagation direction prevented the dislocations from crossing the film to the surface region and thus principally led to a drastic reduction in the threading dislocation density in thicker films.
Photonic reservoir computer with output feedback for chaotic time series prediction (2017)

Reservoir Computing is a bio-inspired computing paradigm for processing time dependent signals. It can be easily implemented in hardware. The performance of these analogue devices matches digital algorithms on a series of benchmark tasks. Their capacities could be extended by feeding the output signal back into the reservoir, which would allow them to be applied to various signal generation tasks. In practice, this requires a high-speed readout layer for real-time output computation. Here we achieve this by means of an FPGA chip, and demonstrate the first photonic reservoir computer with output feedback. We test our setup on the Mackey-Glass chaotic time series generation task and obtain interesting prediction horizons, comparable to numerical simulations, with ample room for further improvement. Our work thus demonstrates the potential offered by the output feedback and opens a new area of novel applications for photonic reservoir computing.
Synthesis of an amino‐terminated hyperbranched polymer and its application in reactive dyeing on cotton as a salt‐free dyeing auxiliary (2007)

A water‐soluble amino‐terminated hyperbranched polymer was synthesised from methyl acrylate and diethylene triamine by melt polycondensation. Its molecular weight and possible structure were characterised by gel permeation chromatography, Fourier transform infrared spectrophotometry and nuclear magnetic resonance spectroscopy. The zeta potential of cotton fabrics treated with the aqueous solution of the amino‐terminated hyperbranched polymer (6 g dm −3 ) in the presence of citric acid (2 g dm −3 ) and sodium hypophosphite (3 g dm −3 ) of the liquid phase is positive at pHs lower than 7.5. Dyed with reactive dyes, the treated cotton fabric displayed a markedly enhanced colour strength, even when dyeing had been carried out in the absence of the electrolyte. The washing fastness, rubbing fastness and levelling properties of the dyed, treated cotton fabrics were also good compared with that obtained by conventional dyeing. The dyeing behaviour of Reactive Brilliant Yellow A‐4GLN on treated cotton fabric was examined and found to follow a Langmuir‐type adsorption curve. It is concluded that the amino‐terminated hyperbranched polymer can be used as a salt‐free auxiliary in reactive dyeing on cotton.
Myocardial perfusion imaging with technetium-99m-sestamibi: comparative analysis of available imaging protocols. (1994)

Several protocols for rest and stress myocardial perfusion imaging with 99mTc-sestamibi have been developed, each with distinct advantages and disadvantages. The various approaches have similar sensitivities and specificities for detection of coronary artery disease (CAD), but differ mainly in their ability to identify defect reversibility. The dual-isotope approach, with a rest 201Tl study and a stress 99mTc-sestamibi study, permits optimal evaluation of both stress perfusion and defect reversibility. Gated SPECT may be added to any of the protocols and aids in identifying artifacts, defining regional wall thickening and assessing ventricular function. First-pass 99mTc-sestamibi radionuclide angiography can add exercise ventricular function data to the study. Clinical trials have shown that the various protocols for 99mTc-sestamibi provide diagnostic and prognostic information comparable to that derived from traditional 201Tl imaging, with the added advantage of higher quality images and increased certainty in interpretation.
Abstract P019: Exosomes from Human CD34+ Cells: Critical Mediators of Proangiogenic Paracrine Effect of EPCs (2011)

Local transplantation of human CD34+ hematopoietic stem cells has been shown to promote neovascularization in pre-clinical studies in models of myocardial and limb ischemia. In early phase clinical trials, transplantation of CD34+ cells has been associated with reduced angina, improved exercise time and reduced amputation rates. Several studies have suggested that paracrine effects by these pro-angiogenic cells mediate the effects induced by cell transplantation. We hypothesized that CD34+ cells secrete exosomes (Exo), which mediate at least a part of the therapeutic function of the cells. Methods and Results: We isolated Exo from the conditioned media of adult human peripheral blood (PB) CD34+ cells. The angiogenic and therapeutic potency of CD34+ Exo was compared with the intact CD34+ cells and also with PB mononuclear cell (MNC) Exo. Exo from both CD34+ cells and MNC are 50–90nm in size, have cup shaped morphology, and carry known Exo-marker proteins such as CD63, TSG101 and Annexin V as shown by electron microscopy, Western blot and flow cytometry. Compared to CD34+ cells or MNC Exo, CD34+ Exo significantly induces in vitro angiogenic activities such as viability, proliferation and tube formation of HUVECs on matrigel- in a dose dependent manner. In vivo, CD34+ Exo stimulated significant neovascularization in mouse corneal angiogenesis assay (14±4 mm v MNC Exo, 4±1 mm, p&lt;0.01) and incorporation of endothelial (CD31+) cells in mouse matrigel-plug assay (6±1.7% v CD34+ cells, 2±0.8%, p&lt;0.01). Finally, in a mouse model of hind limb ischemia (HLI), CD34+ Exo significantly improved perfusion (ratio: 1.01±0.04 v 0.57±0.1, P&lt;0.05), increased capillary density (1.8±0.3/HPF v 0.9±0.1/HPF, p&lt;0.001) and prevented ischemic leg amputation (16% v 100%), as compared with MNC Exo. Conclusions: These data demonstrate that CD34+ Exo induce angiogenic activity and ischemic tissue repair in the absence of CD34+ cells, and suggest that Exo represent important mediators of the therapeutic effects associated with CD34+ cell therapy. We speculate that Exo derived from CD34+ cells may represent a significant component of the paracrine effect of progenitor-cell transplantation for therapeutic angiogenesis.
Analysis of biochemical genetic data on Jewish populations: II. Results and interpretations of heterogeneity indices and distance measures with respect to standards. (1979)

A nonparametric statistical methodology is used for the analysis of biochemical frequency data observed on a series of nine Jewish and six non-Jewish populations. Two categories of statistics are used: heterogeneity indices and various distance measures with respect to a standard. The latter are more discriminating in exploiting historical, geographical and culturally relevant information. A number of partial orderings and distance relationships among the populations are determined. Our concern in this study is to analyze similarities and differences among the Jewish populations, in terms of the gene frequency distributions for a number of genetic markers. Typical questions discussed are as follows: These Jewish populations differ in certain morphological and anthropometric traits. Are there corresponding differences in biochemical genetic constitution? How can we assess the extent of heterogeneity between and within groupings? Which class of markers (blood typings or protein loci) discriminates better among the separate populations? The results are quite surprising. For example, we found the Ashkenazi, Sephardi and Iraqi Jewish populations to be consistently close in genetic constitution and distant from all the other populations, namely the Yemenite and Cochin Jews, the Arabs, and the non-Jewish German and Russian populations. We found the Polish Jewish community the most heterogeneous among all Jewish populations. The blood loci discriminate better than the protein loci. A number of possible interpretations and hypotheses for these and other results are offered. The method devised for this analysis should prove useful in studying similarities and differences for other groups of populations for which substantial biochemical polymorphic data are available.
Usability testing with total-effort metrics (2009)

Usability testing activities have numerous benefits in theory, yet they are often overlooked or disregarded in practice. A testing paradigm which yields objective, quantitative results would likely lead to more widespread adoption of usability evaluation activities. Total-effort metrics is such a novel framework. This paper describes a usability study conducted using a total-effort metrics approach. In this study, subjects interact with three interfaces which have varying element layout proximities. The time and effort measures of time-on-task, total keystrokes, correctional keystrokes, saccade amplitude (point-to-point eye movement) and gaze-path traversal are recorded and analyzed. The findings of the study demonstrate a correlation between the intrinsic effort of an interface and its usability as predicted by extant interface layout guidelines.
Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit. (1994)

We show here that the class I human cytoplasmic isoleucyl-tRNA synthetase is an exceptionally large polypeptide (1266 aa) which, unlike its homologues in lower eukaryotes and prokaryotes, has a third domain of two repeats of an approximately 90-aa sequence appended to its C-terminal end. While extracts of Escherichia coli do not aminoacrylate mammalian tRNA with isoleucine, expression of the cloned human gene in E. coli results in charging of the mammalian tRNA substrate. The appended third domain is dispensable for detection of this aminoacylation activity and may be needed for assembly of a multisynthetase complex in mammalian cells. Alignment of the sequences of the remaining two domains shared by isoleucyl-tRNA synthetases from E. coli to human reveals a much greater selective pressure on the domain needed for tRNA acceptor helix interactions and catalysis than on the domain needed for interactions with the anticodon. This result may have implications for the historical development of an operational RNA code for amino acids.
Tunable microwave TM010 mode cavity of simple construction with improved performance for gas breakdown and materials investigation (1982)

The paper describes the construction of a tunable microwave (2.45 GHz) TM010 mode cylindrical cavity which has improved features in the measurement of gas discharge phenomena and properties of materials. Theoretical work, supported by experiment, demonstrates that during controlled end-wall deformation tuning ranges of at least ± 40 MHz are achieved, for which there is negligible change in the electric field at the cavity axis. An additional feature is that a linear law relates the deformation depth to the resulting frequency change, over the useful tuning range. The cavity can be fabricated simply, and with relaxed tolerances. Accurately made tuning stubs are not required, and their absence ensures a gas-tight structure.
Comparison of three tonometers for measuring intraocular pressure in rabbits. (1996)

The Tono-pen XL is the tonometer of choice for measuring IOP in rabbits within the range of IOP 3 to 30 mm Hg. All tonometers were less accurate when the IOP was elevated markedly.
Effective anti‐metastatic melanoma vaccination with tumor cells transfected with MHC genes and/or infected with newcastle disease virus (NDV) (1994)

The therapeutic efficacy of active immunization with B16-F10.9 melanoma cells transfected with syngeneic major histocompatibility complex (MHC) class-I genes, modified by infection with Newcastle Disease virus (NDV) or modified by both treatments, was compared. B16-F10.9 tumor-bearing mice were treated at various stages of tumor growth and metastasis with irradiated, modified tumor-cell vaccines. Irradiated tumor cells and H-2Db transfectants did not stimulate anti-tumor immunity while H-2Kb transfectants and NDV-modified F10.9 cells showing low and high expression of MHC class-I genes efficiently prevented metastasis of small established tumors. NDV-modified parental-cell vaccines functioned optimally and improved overall survival by about 60%, also at early stages of metastasis establishment. A synergistic effect of H-2Kb expression and virus modification on rejection of micrometastases was observed in mice bearing advanced tumors. Postoperative vaccination of mice carrying multiple metastases with NDV-modified vaccines caused significant, but incomplete, reduction of metastatic tumor load. The therapeutic effect of NDV-modified tumor vaccines was dependent on multiple immune mechanisms. Depletion of CD8, CD4 or NK cells by in vivo treatment with monoclonal antibodies reversed the immunotherapeutic effects of the vaccine. Thus, tumor xenogenization and gene modification may act synergistically to vaccinate against advanced tumors, while single modalities can effectively vaccinate against metastasis at early stages of tumor growth.
Complete trisomy 17p a relatively new syndrome. (1988)

A patient with a de novo duplication of 17p is described. A comparison with five other published cases indicates several features in common that seem characteristic of the syndrome. Primary features include, low birth weight, small size, severe mental and motor retardation, heart defect, failure to thrive and peculiar facial traits. The prominent facial features are, a tendency for round and flat mid face, small palpebral fissures, hypertelorism, microcephaly and low set prominent ears.
Aspirin: Dissolution Rates of Two Polymorphic Forms (1968)

Two polymorphic forms of aspirin were characterized; the rates of dissolution of single crystals and of tablets were studied. One forms dissolves 50 percent faster than the other.
QT dispersion and late potentials during doxorubicin therapy for non‐Hodgkin’s lymphoma (1999)

Prolongation of QTc, increased QT dispersion and development of late potentials are indicative of doxorubicin-induced abnormal ventricular depolarization and repolarization. QT dispersion and late potentials are both known to be associated with increased risk of serious ventricular dysrhythmias and sudden death in various cardiac diseases. Thus, follow-up of these parameters might also be useful in assessing the risk of late cardiovascular events in cancer patients treated with anthracyclines.
Intrathecal, but Not Intravenous, Clonidine Reduces Experimental Thermal or Capsaicin-Induced Pain and Hyperalgesia in Normal Volunteers (1998)

To the extent that the experimental pain conditions used in this study reflect those in patients with acute and chronic pain, these data support the spinal rather than IV injection of clonidine for analgesia.
Large-area nanopatterned graphene for ultrasensitive gas sensing (2014)

Chemical vapor deposited (CVD) graphene is nanopatterned using a spherical block copolymer etch mask. The use of spherical rather than cylindrical block copolymers allows homogeneous patterning of cm-scale areas without any substrate surface treatment. Raman spectroscopy was used to study the controlled generation of point defects in the graphene lattice with increasing etching time, confirming that alongside the nanomesh patterning, the nanopatterned CVD graphene presents a high defect density between the mesh holes. The nanopatterned samples showed sensitivities for NO2 of more than one order of magnitude higher than for non-patterned graphene. NO2 concentrations as low as 300 ppt were detected with an ultimate detection limit of tens of ppt. This is the smallest value reported so far for non-UV illuminated graphene chemiresistive NO2 gas sensors. The dramatic improvement in the gas sensitivity is believed to be due to the high adsorption site density, thanks to the combination of edge sites and point defect sites. This work opens the possibility of large area fabrication of nanopatterned graphene with extremely high densities of adsorption sites for sensing applications.