Ophthalmic drug delivery system: Challenges and approaches (2010)

Promising management of eye ailments take off effective concentration of drug at the eye for sufficient period of time. Ocular drug delivery is hampered by the barriers protecting the eye. The bioavailability of the active drug substance is often the major hurdle to overcome. Conventional ocular dosage form, including eye drops, are no longer sufficient to combat ocular diseases. This article reviews the constraints with conventional ocular therapy, essential factors in ocular pharmacokinetics, and explores various approaches like eye ointments, gel, viscosity enhancers, prodrug, penetration enhancers, microparticles, liposomes, niosomes, ocular inserts, implants, intravitreal injections, nanoparticles, nanosuspension, microemulsion, in situ-forming gel, iontophoresis, and periocular injections to improve the ocular bioavailability of drug and provide continuous and controlled release of the drug to the anterior and posterior chamber of the eye and selected pharmacological future challenges in ophthalmology. In near future, a great deal of attention will be paid to develop noninvasive sustained drug release for both anterior and posterior segment eye disorders. Current momentum in the invention of new drug delivery systems hold a promise toward much improved therapies for the treatment of visionthreatening disorders.




	
		
			How to Cite this Article
		
		
			Pubmed Style
			
			Patel PB, Shastri DH, Shelat PK, Shukla AK. Drug Delivery System: Challenges and SRP. 2010; 1(2): 114-120. doi:10.4103/0975-8453.75042
			
			Web Style
			
			Patel PB, Shastri DH, Shelat PK, Shukla AK. Drug Delivery System: Challenges and http://www.sysrevpharm.org/?mno=302644614 [Access: March 28, 2021]. doi:10.4103/0975-8453.75042

			
			AMA (American Medical Association) Style

			Patel PB, Shastri DH, Shelat PK, Shukla AK. Drug Delivery System: Challenges and SRP. 2010; 1(2): 114-120. doi:10.4103/0975-8453.75042

			
			Vancouver/ICMJE Style

			Patel PB, Shastri DH, Shelat PK, Shukla AK. Drug Delivery System: Challenges and SRP. (2010), [cited March 28, 2021]; 1(2): 114-120. doi:10.4103/0975-8453.75042

			
			Harvard Style

			Patel PB, Shastri DH, Shelat PK, Shukla AK (2010) Drug Delivery System: Challenges and SRP, 1 (2), 114-120. doi:10.4103/0975-8453.75042

			
			Turabian Style

			Patel PB, Shastri DH, Shelat PK, Shukla AK. 2010. Drug Delivery System: Challenges and Systematic Reviews in Pharmacy, 1 (2), 114-120. doi:10.4103/0975-8453.75042

			
			Chicago Style

			Patel PB, Shastri DH, Shelat PK, Shukla AK. Ophthalmic Drug Delivery System: Challenges and Approaches. Systematic Reviews in Pharmacy 1 (2010), 114-120. doi:10.4103/0975-8453.75042

			
			MLA (The Modern Language Association) Style

			Patel PB, Shastri DH, Shelat PK, Shukla AK. Ophthalmic Drug Delivery System: Challenges and Approaches. Systematic Reviews in Pharmacy 1.2 (2010), 114-120. Print. doi:10.4103/0975-8453.75042

			
			APA (American Psychological Association) Style

			Patel PB, Shastri DH, Shelat PK, Shukla AK (2010) Drug Delivery System: Challenges and Systematic Reviews in Pharmacy, 1 (2), 114-120. doi:10.4103/0975-8453.75042