gebhart/patrepeval huggingface dataset:
Breaking the Silence: An Analysis of Police Questioning under Section 23(4) of the New Zealand Bill of Rights Act 1990 (2008)

This article examines section 23(4) of the New Zealand Bill of Rights Act 1990, which provides arrested and detained individuals with the right to refrain from making any statements. The article begins by undertaking a purposive analysis. It concludes that there are two purposes within the right. The first is to minimise State coercion experienced by individuals who are arrested or detained, in order to promote the objectives of autonomy, dignity, fairness and reliability of statements. Secondly, it upholds a wider purpose of ensuring the obligation of investigating and prosecuting crime is on the State. The article then examines the recent Court of Appeal decision of R v Ormsby which held that the police are not obliged to cease questioning when an individual asserts the right to pre-trial silence under section 23(4). It is argued that the Court based this decision on inappropriate case law and without proper examination of the purposes underlying section 23(4). Instead, an 'absolute approach' as applied in the United States appears to accord more with the purposes of section 23(4). Although the article stops short of advocating that the absolute approach should adopted, it does argue that the courts should immediately revisit the issue of continued police questioning, as the current approach does not appear to be consistent with the purposes of section 23(4). By comparison, the absolute approach may be more suitable.
The Coda Distributed File System (1998)

Carnegie Mellon University has developed an exciting file system. Mr. Braam, one of the developers, tells us all about it
Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo. (1997)

Coagulation proteases were tested in a rat model of acute inflammation. Subplantar injection of Factor Xa (10-30 microg) produced a time- and dose-dependent edema in the rat paw, and potentiated carrageenin-induced edema. In contrast, the homologous protease Factor IXa was ineffective. This inflammatory response was recapitulated by the Factor Xa sequence L83FTRKL88(G), which mediates ligand binding to effector cell protease receptor-1 (EPR-1), while a control scrambled peptide did not induce edema in vivo. Conversely, injection of the EPR-1-derived peptide S123PGKPGNQNSKNEPP137 (corresponding to the receptor binding site for Factor Xa) inhibited carrageenin-induced rat paw edema, while the adjacent EPR-1 sequence P136PKKRERERSSHCYP150 was without effect. EPR-1-Factor Xa-induced inflammation was characterized by fast onset and prominent perivascular accumulation of activated and degranulated mast cells, was inhibited by the histamine/serotonin antagonists cyproheptadine and methysergide, but was unaffected by the thrombin-specific inhibitor, Hirulog. These findings suggest that through its interaction with EPR-1, Factor Xa may function as a mediator of acute inflammation in vivo. This pathway may amplify both coagulation and inflammatory cascades, thus contributing to the pathogenesis of tissue injury in vivo.
MultiPath: Multiple Probabilistic Anchor Trajectory Hypotheses for Behavior Prediction (2019)

Predicting human behavior is a difficult and crucial task required for motion planning. It is challenging in large part due to the highly uncertain and multi-modal set of possible outcomes in real-world domains such as autonomous driving. Beyond single MAP trajectory prediction, obtaining an accurate probability distribution of the future is an area of active interest. We present MultiPath, which leverages a fixed set of future state-sequence anchors that correspond to modes of the trajectory distribution. At inference, our model predicts a discrete distribution over the anchors and, for each anchor, regresses offsets from anchor waypoints along with uncertainties, yielding a Gaussian mixture at each time step. Our model is efficient, requiring only one forward inference pass to obtain multi-modal future distributions, and the output is parametric, allowing compact communication and analytical probabilistic queries. We show on several datasets that our model achieves more accurate predictions, and compared to sampling baselines, does so with an order of magnitude fewer trajectories.
Targeted Elimination of Prostate Cancer by Genetically Directed Human T Lymphocytes (2005)

The genetic transfer of antigen receptors is a powerful approach to rapidly generate tumor-specific T lymphocytes. Unlike the physiologic T-cell receptor, chimeric antigen receptors (CARs) encompass immunoglobulin variable regions or receptor ligands as their antigen recognition moiety, thus permitting T cells to recognize tumor antigens in the absence of human leukocyte antigen expression. CARs encompassing the CD3zeta chain as their activating domain induce T-cell proliferation in vitro, but limited survival. The requirements for genetically targeted T cells to function in vivo are less well understood. We have, therefore, established animal models to assess the therapeutic efficacy of human peripheral blood T lymphocytes targeted to prostate-specific membrane antigen (PSMA), an antigen expressed in prostate cancer cells and the neovasculature of various solid tumors. In vivo specificity and antitumor activity were assessed in mice bearing established prostate adenocarcinomas, using serum prostate-secreted antigen, magnetic resonance, computed tomography, and bioluminescence imaging to investigate the response to therapy. In three tumor models, orthotopic, s.c., and pulmonary, we show that PSMA-targeted T cells effectively eliminate prostate cancer. Tumor eradication was directly proportional to the in vivo effector-to-tumor cell ratio. Serial imaging further reveals that the T cells must survive for at least 1 week to induce durable remissions. The eradication of xenogeneic tumors in a murine environment shows that the adoptively transferred T cells do not absolutely require in vivo costimulation to function. These results thus provide a strong rationale for undertaking phase I clinical studies to assess PSMA-targeted T cells in patients with metastatic prostate cancer.
A Note on the Solubilities of Calcium Soaps (1924)

Research Article| January 01 1924 A Note on the Solubilities of Calcium Soaps Geoffrey Arthur Harrison Geoffrey Arthur Harrison 1The Biochemical Department, The Hospital for Sick Children, Great Ormond Street Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1924) 18 (6): 1222–1223. https://doi.org/10.1042/bj0181222 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Geoffrey Arthur Harrison; A Note on the Solubilities of Calcium Soaps. Biochem J 1 January 1924; 18 (6): 1222–1223. doi: https://doi.org/10.1042/bj0181222 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1924 CAMBRIDGE UNIVERSITY PRESS1924 Article PDF first page preview Close Modal You do not currently have access to this content.
High‐frequency Oscillations after Status Epilepticus: Epileptogenesis and Seizure Genesis (2004)

A strong correlation was found between a decreased time to detection of HFOs and an increased rate of spontaneous seizures, as well as with a decrease in the duration of the latent period between KA injection and the detection of spontaneous seizures. Two types of HFOs were found after KA injection, one in the frequency range of 100 to 200 Hz, and the other, in the frequency range of 200 to 500 Hz, and both should be considered pathological, suggesting that both are epileptogenic.
Map-Aided Evidential Grids for Driving Scene Understanding (2015)

Evidential grids have recently been shown to have interesting properties for mobile object perception. Possessing only partial information is a frequent situation when driving in complex urban areas, and by making use of the Dempster-Shafer framework, evidential grids are able to handle partial information efficiently. This article deals with a lidar perception scheme that is enhanced by geo-referenced maps used as an additional source of information in a multi-grid fusion framework. The paper looks at the key stages of such a data fusion process and presents an adaptation of the conjunctive combination rule for refining the analysis of conflicting information. This method relies on temporal accumulation to distinguish between stationary and moving objects, and applies contextual discounting for modeling information obsolescence. As a result, the method is able to better characterize the state of the occupied cells by differentiating moving objects, parked cars, urban infrastructure and buildings. Another advantage of this approach is its ability to separate the drivable from the non-drivable free space. Experiments carried out in real traffic conditions with a specially equipped car illustrate the performance of this approach.
Optical properties of small-bore hollow glass waveguides (1995)

Hollow glass waveguides with a 250-µm i.d. have been fabricated with a liquid-phase deposition technique that uses silica tubing as a base material. The losses of the 250-µm-bore guide measured at CO(2) laser wavelengths are as low as 2.0 dB/m. The straight losses for the hollow guides are in good agreement with theoretically predicted losses as a result of the nearly ideal structure of the guides. It is also shown that the guides have low bending losses, a nearly pure-mode delivery, and good high-power laser transmission. By proper design of the dielectric thickness, the guide is also able to deliver Er:YAG laser energy with a low loss of 1.2 dB/m for the 320-µm-bore waveguide. Because the hollow glass waveguide is very flexible and robust, it is quite suitable for medical applications.
Synthesis, Self-Assembly, and Charge Transporting Property of Contorted Tetrabenzocoronenes (2010)

A facile route has been developed for the preparation of a new family of contorted 1.2,3.4,7.8,9.10-tetrabenzocoronenes (TBCs). A two-step cyclization reaction, i.e., oxidative photocyclization followed by FeCl(3)-mediated intramolecular cyclodehydrogenation, was carried out on the olefin precursors to obtain the final TBC compounds. These new TBC molecules have contorted conformation due to steric overcrowding as disclosed by single-crystal crystallographic analysis. Nevertheless, they showed extended π-conjugation compared with coronene and exhibited strong aggregation in solution. The thermal behavior and self-assembly of TBC-C8 in solid were studied by a combination of thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), scanning electron microscope (SEM), and transmission electron microscope (TEM). Compound TBC-C8 showed very good thermal and photostability and exhibited long-range ordered π-stacking in the bulk state. Moreover, uniform nanofibers with tens of micrometer length are formed in the drop-casted thin films. TBC-C8 also possesses a desirable HOMO energy level (-5.10 eV), which allows efficient charge injection from electrodes such as gold electrode. The charge carrier mobilities were determined by using the space-charge limited-current (SCLC) technique and high average hole mobility of 0.61 cm(2) V(-1) s(-1) was obtained for TBC-C8.
Evaluation of an enzymatic method for determining creatinine in plasma. (1988)

An enzymatic kit method for the determination of plasma creatinine was optimised for use with a centrifugal analyser and its performance characteristics and practicability compared with an end point and a kinetic Jaffé-based method. The enzymatic method exhibited several advantages over Jaffé-based methods--namely, smaller sample size, rapid sample throughput (200 per hour), and improved specificity. Glucose, acetoacetate, and cefoxitin did not interfere with the enzymatic method, although bilirubin did cause a negative interference which depended on both creatinine and bilirubin concentrations. The enzymatic method has particular clinical application in neonates, diabetic ketotic patients, and those receiving cephalosporins.
STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing (2009)

Signal transducer and activator of transcription (STAT) 3 is a pleiotropic transcription factor with important functions in cytokine signaling in a variety of tissues. However, the role of STAT3 in the intestinal epithelium is not well understood. We demonstrate that development of colonic inflammation is associated with the induction of STAT3 activity in intestinal epithelial cells (IECs). Studies in genetically engineered mice showed that epithelial STAT3 activation in dextran sodium sulfate colitis is dependent on interleukin (IL)-22 rather than IL-6. IL-22 was secreted by colonic CD11c(+) cells in response to Toll-like receptor stimulation. Conditional knockout mice with an IEC-specific deletion of STAT3 activity were highly susceptible to experimental colitis, indicating that epithelial STAT3 regulates gut homeostasis. STAT3(IEC-KO) mice, upon induction of colitis, showed a striking defect of epithelial restitution. Gene chip analysis indicated that STAT3 regulates the cellular stress response, apoptosis, and pathways associated with wound healing in IECs. Consistently, both IL-22 and epithelial STAT3 were found to be important in wound-healing experiments in vivo. In summary, our data suggest that intestinal epithelial STAT3 activation regulates immune homeostasis in the gut by promoting IL-22-dependent mucosal wound healing.
Purification of 4S-limonene synthase, a monoterpene cyclase from the glandular trichomes of peppermint (Mentha x piperita) and spearmint (Mentha spicata). (1992)

The p-menthane monoterpenes of the Mentha species are biosynthesized from geranyl pyrophosphate via the monocyclic olefin 4S-limonene. A monoterpene cyclase was isolated from both Mentha x piperita (peppermint) and Mentha spicata (spearmint) that catalyzes the cyclization of geranyl pyrophosphate to 4S-limonene. This enzyme, 4S-limonene synthase, was purified to apparent homogeneity by dye ligand, anion exchange, and hydrophobic interaction chromatography. Since the monoterpenes of Mentha are synthesized and secreted in modified epidermal hairs called glandular trichomes, an extract of isolated glandular trichome cells was used as the source of this enzyme. A combination of gel permeation chromatography and sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that purified 4S-limonene synthase had a native molecular weight of 56,000 and was monomeric. The principal product of the enzyme was enantiomerically pure (-)-4S-limonene, and a catalytic constant of 0.3/s was determined. The basic properties of 4S-limonene synthase from both M. x piperita and M. spicata are identical and, in general, are similar to those of other monoterpene, sesquiterpene, and diterpene cyclases isolated from microorganisms and higher plants.
Synergistic Electrochemical CO2 Reduction and Water Oxidation with a Bipolar Membrane (2016)

The electrochemical conversion of CO2 and water to value-added products still suffers from low efficiency, high costs, and high sensitivity to electrolyte, pH, and contaminants. Here, we present a strategy for this reaction using a silver catalyst for CO2 reduction in a neutral catholyte, separated by a bipolar membrane from a nickel iron hydroxide oxygen evolution catalyst in a basic anolyte. This combination of electrolytes provides a favorable environment for both catalysts and shows the effective use of bicarbonate and KOH to obtain low cell voltages. This architecture brings down the total cell voltage by more than 1 V compared to that with conventional use of a Pt counter electrode and monopolar membranes, and at the same time, it reduces contamination and improves stability at the cathode.
Addition-Fragmentation Chain Transfer in Free Radical Styrene Polymerization in the Presence of 2,4-Diphenyl-4-methyl-1-pentene (1993)

Abstract Thermal polymerization of styrene in the presence of 2,4-diphenyl-4-methyl-1-pentene (α-MSD) gave a low molecular weight polymer having a terminal double bond and a cumyl moiety without lowering the polymerization rate. A chain transfer mechanism through addition-fragmentation reaction is presented.
NERVOUS CONTROL OF MICTURITION (1989)

The normal micturition depends on a highly elaborate control system that comprises central and peripheral nerves. The recent research on the nervous control of micturition has been markedly progressing. This paper reviews the latest understanding of 1) the functional anatomy of lower urinary tract, 2) the peripheral nervous system and nuclei in the spinal cord, 3) the neurotransmitters and receptors, 4) nervous reflex mechanism of micturition, 5) pontine micturition center, 6) pontine urine storage center and 7) neural connections between pons, higher centers and lower centers.
Ultrastable PbSe Nanocrystal Quantum Dots via in Situ Formation of Atomically Thin Halide Adlayers on PbSe(100) (2014)

The fast degradation of lead selenide (PbSe) nanocrystal quantum dots (NQDs) in ambient conditions impedes widespread deployment of the highly excitonic, thus versatile, colloidal NQDs. Here we report a simple in situ post-synthetic halide salt treatment that results in size-independent air stability of PbSe NQDs without significantly altering their optoelectronic characteristics. From TEM, NMR, and XPS results and DFT calculations, we propose that the unprecedented size-independent air stability of the PbSe NQDs can be attributed to the successful passivation of under-coordinated PbSe(100) facets with atomically thin PbX2 (X = Cl, Br, I) adlayers. Conductive films made of halide-treated ultrastable PbSe NQDs exhibit markedly improved air stability and behave as an n-type channel in a field-effect transistor. Our simple in situ wet-chemical passivation scheme will enable broader utilization of PbSe NQDs in ambient conditions in many optoelectronic applications.
Conversion of nicotine to nornicotine in Nicotiana tabacum is mediated by CYP82E4, a cytochrome P450 monooxygenase (2005)

Nornicotine is a secondary tobacco alkaloid that is produced by the N-demethylation of nicotine. Nornicotine production and accumulation in tobacco are undesirable because nornicotine serves as the precursor in the synthesis of the well characterized carcinogen N'-nitrosonornicotine during the curing and processing of tobacco. Although nornicotine is typically a minor alkaloid in tobacco plants, in many tobacco populations a high percentage of individuals can be found that convert a substantial proportion of the nicotine to nornicotine during leaf senescence and curing. We used a microarray-based strategy to identify genes that are differentially regulated between closely related tobacco lines that accumulate either nicotine (nonconverters) or nornicotine (converters) as the predominant alkaloid in the cured leaf. These experiments led to the identification of a small number of closely related cytochrome P450 genes, designated the CYP82E2 family, whose collective transcript levels were consistently higher in converter versus nonconverter tobacco lines. RNA interference-induced silencing of the CYP82E2 gene family suppressed the synthesis of nornicotine in strong converter plants to levels similar to that observed in nonconverter individuals. Although each of the six identified members of the P450 family share >90% nucleotide sequence identity, sense expression of three selected isoforms revealed that only one (CYP82E4v1) was involved in the conversion of nicotine to nornicotine. Yeast expression analysis revealed that CYP82E4v1 functions as a nicotine demethylase. Identification of the gene(s) responsible for nicotine demethylation provides a potentially powerful tool toward efforts to minimize nornicotine levels, and thereby N'-nitrosonornicotine formation, in tobacco products.
The analysis of mock DNA sequencing reactions using matrix‐assisted laser desorption/ionization mass spectrometry (1993)

Abstract A mock sequencing experiment is described in which matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry is used to analyze mixtures of synthetic oligodeoxynucleotides chosen to match the first 24 DNA fragments generated in typical sequencing reactions using a standard M13mp19 template and primer. The experiments permitted the evaluation of important issues relating to resolution, sensitivity, multiple charging, and adduct formation. Mass resolutions (full width at half maximum) were between 100 and 200, and it was relatively straightforward to assign bases in the sequencing simulation using subpicomolar quantities of material. These results demonstrate the potential of MALDI mass spectrometry in DNA sequence analysis.
A Study of Aliphatic Sulfonyl Compounds. VIII. The Thermal Decomposition of Trimethylmethanesulfonyl Chloride1 (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Study of Aliphatic Sulfonyl Compounds. VIII. The Thermal Decomposition of Trimethylmethanesulfonyl Chloride1Robert T. van Aller, Robert B. Scott Jr., and Edmund L. BrockelbankCite this: J. Org. Chem. 1966, 31, 7, 2357–2365Publication Date (Print):July 1, 1966Publication History Published online1 May 2002Published inissue 1 July 1966https://pubs.acs.org/doi/10.1021/jo01345a066https://doi.org/10.1021/jo01345a066research-articleACS PublicationsRequest reuse permissionsArticle Views365Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts