gebhart/patrepeval huggingface dataset:
Composite Electrodes Containing Conducting Polymers and Li Alloys (1988)

Attractive charge capacities, reversibility, and mechanical stability have been demonstrated at ambient temperature by composite film anodes of polyacetylene or poly(p‐phenylene) with or alloys. The alloys were dispersed in finely divided form throughout the conducting polymer matrix in a configuration that minimized alloy degradation processes associated with exfoliation, surface passivation, and inefficient Li diffusion.
Silica encapsulated manganese perovskite nanoparticles for magnetically induced hyperthermia without the risk of overheating (2009)

Nanoparticles of manganese perovskite of the composition La(0.75)Sr(0.25)MnO(3) uniformly coated with silica were prepared by encapsulation of the magnetic cores (mean crystallite size 24 nm) using tetraethoxysilane followed by fractionation. The resulting hybrid particles form a stable suspension in an aqueous environment at physiological pH and possess a narrow hydrodynamic size distribution. Both calorimetric heating experiments and direct measurements of hysteresis loops in the alternating field revealed high specific power losses, further enhanced by the encapsulation procedure in the case of the coated particles. The corresponding results are discussed on the basis of complex characterization of the particles and especially detailed magnetic measurements. Moreover, the Curie temperature (335 K) of the selected magnetic cores resolves the risk of local overheating during hyperthermia treatment.
Genèse de l'innovation et culture technique (1986)

P f RANSFERTS technologiques , culture techni-1 que, autant d'expressions d'une gnralit trop B accueillante pour ne pas susciter quelque rserve : employs ensemble, ces piments du discours sur l'innovation risquent d'agacer le got du lecteur le mieux dispos.Essayer d'en prciser la composition et l'usage, c'est peut-tre prendre le risque de le dcourager dfinitivement, le praticien restant dubitatif quant l'intrt concret de ces notions -nous l'invitons aborder directement la seconde partie de l'article : Quelques exemples de transfert -et le thoricien de la connaissance pouvant s'effaroucher de la rusticit d'un transfert technique lorsqu'on le compare aux transferts de paradigmes et aux diverses formes de rductionnisme.Nanmoins, le transfert technique illustre quelques-uns des mcanismes gnraux de la progression des connaissances, et son observation peut contribuer une meilleure comprhension du fonctionnement de la communaut scientifique et des rapports science-socit.La notion de culture technique est aussi fconde qu'ambigu : elle dsigne tantt un savoir opratif, un mtier , oppos une culture savante, tantt le substrat thorique de ces savoirfaire (d'Iribarne) : la culture technique se trouve place au coeur des analyses de la qualification dans son rapport avec le change-
The Effect of Prostaglandins on the Dermal Microcirculation After Burning, and the Inhibition of the Effect by Specific Pharmacological Agents (1979)

The Effect of Prostaglandins on the Dermal Microcirculation After Burning, and the Inhibition of the Effect by Specific Pharmacological Agents: PDF Only
Overexpression of interleukin‐12 enables dendritic cells to activate NK cells and confer systemic antitumor immunity (2003)

Dendritic cells (DC) are initiators of T cell-mediated immunity. However, less is known about the relationship between DC and natural killer (NK) cells, and direct evidence of their interaction in vivo is scarce. Interleukin (IL)-12 is an activator of both DC and NK cells. We postulated that secretion of IL-12 by DC would enable them to activate NK cells. Bone marrow-derived DC propagated only in granulocyte macrophage colony-stimulating factor did not activate NK cells. In contrast, DC engineered to express IL-12 markedly stimulated NK cells as determined by coculture experiments in vitro, assays of NK cells isolated from treated animals, and survival experiments in a systemic tumor model. Activation depended on both DC-NK cellular interaction and secretion of IL-12. Adoptive transfer of DC expressing IL-12 to mice markedly increased NK cell interferon-gamma production and lytic activity in vivo. Treated mice were also protected against B16 melanoma hepatic metastases. The in vivo effects on NK cells were DC-specific. Administration of IL-12 protein alone or melanoma cells or fibroblasts engineered to secrete IL-12 were only weakly activating. Our findings demonstrate that IL-12 expression by DC enables them to activate NK cells and provide evidence for a substantial DC-NK relationship in vivo.
Identification and biological applications of rhegnylogically-organized cell penetrating peptides. (2007)

Acknowledgments: We are extremely grateful to Ülo Langel (Stockholm) who provided access to the CPP prediction algorithm. This work also benefited from collaborations with Shant Kumar (Manchester) and Matjaž Zorko (Ljubljana). These investigations were financially supported in part by the Samantha Dickson Brain Tumour Trust.
54. Measurement of uptake of radiopharmaceuticals in bone marrow with intraoperative bone marrow sampling (1992)

Oyen, W. J.G.; van Kampen, A.; Buijs, W. C.A.M.; Claessens, R. A.M.J.; Koenders, E. B.; Corstens, F. H.M. Author Information
Sorting of LPXTG Peptides by Archetypal Sortase A: Role of Invariant Substrate Residues in Modulating the Enzyme Dynamics and Conformational Signature of a Productive Substrate (2014)

Transpeptidase sortase catalyzes the covalent anchoring of surface proteins to the cell wall in Gram-positive bacteria. Sortase A (SrtA) of Staphylococcus aureus is a prototype enzyme and considered a bona fide drug target because several substrate proteins are virulence-related and implicated in pathogenesis. Besides, SrtA also works as a versatile tool in protein engineering. Surface proteins destined for cell wall anchoring contain a LPXTG sequence located in their C-terminus which serves as a substrate recognition motif for SrtA. Recent studies have implicated substrate-induced conformational dynamics in SrtA. In the present work, we have explored the roles of invariant Leu and Pro residues of the substrate in modulating the enzyme dynamics with a view to understand the selection process of a catalytically competent substrate. Overall results of molecular dynamics simulations and experiments carried out with noncanonical substrates and site-directed mutagenesis reveal that the kinked conformation due to Pro in LPXTG is obligatory for productive binding but does not per se control the enzyme dynamics. The Leu residue of the substrate appears to play the crucial role of an anchor to the beta6-beta7 loop directing the conformational transition of the enzyme from an "open" to a "closed" state subsequent to which the Pro residue facilitates the consummation of binding through predominant engagement of the loop and catalytic motif residues in hydrophobic interactions. Collectively, our study provides insights about specificity, tolerance, and conformational sorting of substrate by SrtA. These results have important implications in designing newer substrates and inhibitors for this multifaceted enzyme.
Magnetic properties of α‐Fe 2 O 3 nanopallets (2017)

Abstract It is the result of a systemic study about uniform hematite nanopallets with length of about 100 nm, width of about 30 nm, and thickness of less than 10 nm. The sample has superparamagnetic (SPM) properties above the blocking temperature of ~16 K. The temperature dependence of magnetization was well fitted by Bloch T 3/2 law considering the dipolar interaction of the particles. The field dependence of magnetization was fitted with revised Langevin equation. The magnetization of the weak ferromagnetic (WF) canted spins contributes to the linear portion in the high field region; the surface uncompensated spins and the parasitic ferromagnetic moments due to the canted spins both contribute to the particle moments and the superparamagnetic behavior.
The antibacterial activity of meropenem in combination with gentamicin or vancomycin (1989)

The kinetics of bacterial killing by meropenem alone and in combination with gentamicin (for Pseudomonas aeruginosa) and vancomycin (for Staphylococcus aureus) were studied for two strains of each species. Against the two strains of P. aeruginosa, meropenem at concentrations up to 4 x MIC was rapidly bactericidal--but regrowth occurred by 24 h. The addition of half the MIC of gentamicin to the MIC of meropenem led to a more rapid decline of the colony count and to the prevention of regrowth of the strain which was gentamicin-susceptible. Similar results were obtained for a methicillin-susceptible strain of S. aureus when vancomycin was added at a concentration of half the MIC. A methicillin-resistant strain also was killed by a combination of vancomycin at half the MIC plus meropenem at the MIC. The study showed that the killing action of meropenem against P. aeruginosa and staphylococci is enhanced by the addition of gentamicin or vancomycin respectively.
Optimizing the Trade-off between Single-Stage and Two-Stage Object Detectors using Image Difficulty Prediction (2018)

There are mainly two types of state-of-the-art object detectors. On one hand, we have two-stage detectors, such as Faster R-CNN (Region-based Convolutional Neural Networks) or Mask R-CNN, that (i) use a Region Proposal Network to generate regions of interests in the first stage and (ii) send the region proposals down the pipeline for object classification and bounding-box regression. Such models reach the highest accuracy rates, but are typically slower. On the other hand, we have single-stage detectors, such as YOLO (You Only Look Once) and SSD (Singe Shot MultiBox Detector), that treat object detection as a simple regression problem by taking an input image and learning the class probabilities and bounding box coordinates. Such models reach lower accuracy rates, but are much faster than two-stage object detectors. In this paper, we propose to use an image difficulty predictor to achieve an optimal trade-off between accuracy and speed in object detection. The image difficulty predictor is applied on the test images to split them into easy versus hard images. Once separated, the easy images are sent to the faster single-stage detector, while the hard images are sent to the more accurate two-stage detector. Our experiments on PASCAL VOC 2007 show that using image difficulty compares favorably to a random split of the images. Our method is flexible, in that it allows to choose a desired threshold for splitting the images into easy versus hard.
Imaging objects hidden in scattering media using a fluorescence–absorption technique (1991)

A novel imaging technique is introduced to enhance the quality of an image of an object hidden in a highly scattering medium. In this technique, the object is made luminous, and its luminescent light is selected for imaging while the illuminating light is filtered out. The quality of the image can be further improved by selecting the portion of the luminescence spectrum that is strongly absorbed by the random medium.
Development and Testing of Mathematical Algorithms for Source andStreamer Positioning during Marine Seismic Exploration (1995)

In order to analyse 3D offshore seismic data and utilise the final geophysical product it is necessary to know the position of each gun and hydrophone in the spread for each shot. In recent years the problem has become extremely complex, mainly due to an expansion of the type and quantity of survey data collected. Moreover it has become increasingly common for clients to require proof (often in real time) that the survey &apos;quality&apos; specifications are being met. Hence there is today a real need to develop a completely general (for flexibility purposes), rigorous and integrated (for error propagation, and therefore QA/QC purposes) approach to the positioning of guns and hydrophones during seismic exploration and this paper is an attempt to address that need. It describes the mathematical basis and implementation of a Kalman filter that can, in principle, handle any number of vessels, streamers and guns and any set of observations to produce either realtime or post-processed positions and quality (precision and reliability) measures - a filter that can also be used prior to data collection to test the suitability of a proposed set of measurements to meet the positioning quality specifications. The paper also describes tests that were conducted using a real set of marine seismic positioning data.
New Bayesian Discriminator for Detection of Atrial Tachyarrhythmias (2002)

This new Bayesian discriminator algorithm, based on Bayes decision of multiple features of atrial electrograms, allows rapid on-line and accurate (98%) detection of AF with robust anti-noise performance.
Radiation-Enhanced Vascular Targeting of Human Lung Cancers in Mice with a Monoclonal Antibody That Binds Anionic Phospholipids (2007)

These results suggest that 2aG4 enhances the antitumor effects of radiation therapy by increasing antibody-dependent cell-mediated cytotoxicity toward tumor vessels with externalized phosphatidylserine. Bavituximab, a chimeric version of 2aG4 in clinical trials, has the potential to enhance the therapeutic efficacy of radiation therapy in lung cancer patients.
Blue-Enriched White Light Improves Performance but Not Subjective Alertness and Circadian Adaptation During Three Consecutive Simulated Night Shifts (2020)

Use of blue-enriched light has received increasing interest regarding its activating and performance sustaining effects. However, studies assessing effects of such light during night work are few, and novel strategies for lighting using light emitting diode (LED) technology need to be researched. In a counterbalanced crossover design, we investigated the effects of a standard polychromatic blue-enriched white light (7000 K; ∼200 lx) compared to a warm white light (2500 K), of similar photon density (∼1.6 × 10<sup>14</sup> photons/cm<sup>2</sup>/s), during three consecutive simulated night shifts. A total of 30 healthy participants [10 males, mean age 23.3 (<i>SD</i> = 2.9) years] were included in the study. Dependent variables comprised subjective alertness using the Karolinska Sleepiness Scale, a psychomotor vigilance task (PVT) and a digit symbol substitution test (DSST), all administered at five time points throughout each night shift. We also assessed dim-light melatonin onset (DLMO) before and after the night shifts, as well as participants' opinion of the light conditions. Subjective alertness and performance on the PVT and DSST deteriorated during the night shifts, but 7000 K light was more beneficial for performance, mainly in terms of fewer errors on the PVT, at the end of the first- and second- night shift, compared to 2500 K light. Blue-enriched light only had a minor impact on PVT response times (RTs), as only the fastest 10% of the RTs were significantly improved in 7000 K compared to 2500 K light. In both 7000 and 2500 K light, the DLMO was delayed in those participants with valid assessment of this parameter [<i>n</i> = 20 (69.0%) in 7000 K light, <i>n</i> = 22 (78.6%) in 2500 K light], with a mean of 2:34 (<i>SE</i> = 0:14) and 2:12 (<i>SE</i> = 0:14) hours, respectively, which was not significantly different between the light conditions. Both light conditions were positively rated, although participants found 7000 K to be more suitable for work yet evaluated 2500 K light as more pleasant. The data indicate minor, but beneficial, effects of 7000 K light compared to 2500 K light on performance during night work. Circadian adaptation did not differ significantly between light conditions, though caution should be taken when interpreting these findings due to missing data. Field studies are needed to investigate similar light interventions in real-life settings, to develop recommendations regarding illumination for night workers. <b>Clinical Trial Registration:</b> www.ClinicalTrials.gov, identifier NCT03203538.
Surface Binding Affinity Measurements from Order Transitions of Lipid Membrane-Coated Colloidal Particles (2005)

Lipid bilayers can be assembled onto the surface of colloidal silica particles to form a continuous and fluid supported membrane coating. In this configuration, the collective behavior of the colloidal dispersion is governed by interactions between particles and exhibits a sensitive dependency on chemical features of the membrane surface. Protein binding to membrane surface receptors can trigger macroscopic changes in the colloidal order, which provides a label-free readout of such binding events. Here, the relationship between order in the colloidal dispersion and the surface concentration of bound protein is characterized quantitatively in terms of the radial pair distribution function. Using parallel fluorescence measurements for comparison, we construct a scalar measure of the distribution function that exhibits linear proportionality with surface protein binding. This is used to determine binding affinity based only on observations of the colloidal distribution.
Clinical investigation on the development of dependence during oral therapy with tramadol. (1985)

In a multicenter study 153 in- and outpatients suffering from severe pain were treated for three weeks with capsules containing 50 mg 1-(m-methoxyphenyl)-2-(dimethylaminomethyl)-cyclohexan-1-ol (tramadol, Tramal). The daily dosage was limited to 400 mg. At the end of the third week the patients received in a randomized double-blind manner 1.6 mg naloxone or saline (both i.m.) to evaluate the risk of developing dependence during the 3-week tramadol treatment (precipitation test). A total of 109 patients completed the trial. Development of tolerance was not observed as was evident from a constant daily tramadol dose associated with constant analgesia. The median net withdrawal scores for the naloxone treated group (mean = 0, Xmin = 0, Xmax = 13) and for the saline treated group (mean = 0, Xmin = 0, Xmax = 5) indicate absence of dependence. The outcome of the study thus suggests that tramadol under the conditions described does not induce dependence.
Ultrastructural Study of the Osteointegration of Bioceramics (Whitlockite and Composite β-TCP + Collagen) in Rabbit Bone (1996)

Study examines the osteointegration of two porous ceramic implants, beta-tricalcium phosphate (beta-TCP) and a composite (beta-TCP-collagen), in femur and tibias of 20 New Zealand white rabbits, which were sacrificed 1 week and 1, 4, and 12 months postimplant so that radiological, optical microscopic, and ultrastructural studies could be carried out. The results show a progressive degradation and resorption of both implant materials by means of a macrophagic reaction, which is at its most intense 1 month postimplant. The materials are substituted by newly formed bone tissue starting at the host bone-implant interface, the substitution being almost total by the end of the study, although less completely and earlier than in the case of the composite. Both materials can be considered as potential substitutes for bone tissue since they are biocompatible, bioreabsorbable, and osteogenic.
INTERNALIZATION OF BACTERIA BY OSTEOBLASTS IN A PATIENT WITH RECURRENT, LONG-TERM OSTEOMYELITIS (2005)

1 Department of Orthopaedic Surgery, Carolinas Medical Center, P.O. Box 32861, Charlotte, NC 28232. E-mail address for H.E. Gruber: [email protected] 2 Health Research Group, P.O. Box 146, Rockbridge Baths, VA 24473
Evidence for a Sexually Transmitted Cofactor for AIDS-Related Kaposiʼs Sarcoma in a Cohort of Homosexual Men (1992)

We examined factors associated with the subsequent development of AIDS-related Kaposi's sarcoma in a cohort of 353 homosexual men infected with human immunodeficiency virus (HIV). Cumulative incidence curves for the development of Kaposi's sarcoma and opportunistic infection were stratified over a wide range of variables at enrollment, including those related to demographics, sexual behavior, illicit drug use, and medical history. We found no strong associations between any of these variables and the development of opportunistic infection, but two were related to Kaposi's sarcoma: use of nitrite inhalants (relative risk, 2.3; 95% confidence interval, 1.0-5.0) and high numbers of sexual contacts during the period 1978-1982 in the AIDS epidemic centers of San Francisco, Los Angeles, and/or New York (relative risk, 3.5; 95% confidence interval, 1.6-7.6). The latter variables remained independently associated with risk of Kaposi's sarcoma even after multivariate adjustment for a number of classical HIV risk factors. These results are consistent with the hypothesis that Kaposi's sarcoma is caused by a sexually transmitted cofactor that has remained more prevalent in the original epidemic centers. The effect of nitrites could be due to an independent biological mechanism or to enhancement of transmission of the cofactor.
Synergistic role of fission yeast Alp16GCP6and Mzt1MOZART1in γ-tubulin complex recruitment to mitotic spindle pole bodies and spindle assembly (2016)

In fission yeast, γ-tubulin ring complex (γTuRC)-specific components Gfh1(GCP4), Mod21(GCP5), and Alp16(GCP6) are nonessential for cell growth. Of these deletion mutants, only alp16Δ shows synthetic lethality with temperature-sensitive mutants of Mzt1(MOZART1), a component of the γTuRC required for recruitment of the complex to microtubule-organizing centers. γ-Tubulin small complex levels at mitotic spindle pole bodies (SPBs, the centrosome equivalent in fungi) and microtubule levels for preanaphase spindles are significantly reduced in alp16Δ cells but not in gfh1Δ or mod21Δ cells. Furthermore, alp16Δ cells often form monopolar spindles and frequently lose a minichromosome when the spindle assembly checkpoint is inactivated. Alp16(GCP6) promotes Mzt1-dependent γTuRC recruitment to mitotic SPBs and enhances spindle microtubule assembly in a manner dependent on its expression levels. Gfh1(GCP4) and Mod21(GCP5) are not required for Alp16(GCP6)-dependent γTuRC recruitment. Mzt1 has an additional role in the activation of the γTuRC for spindle microtubule assembly. The ratio of Mzt1 to γTuRC levels for preanaphase spindles is higher than at other stages of the cell cycle. Mzt1 overproduction enhances spindle microtubule assembly without affecting γTuRC levels at mitotic SPBs. We propose that Alp16(GCP6) and Mzt1 act synergistically for efficient bipolar spindle assembly to ensure faithful chromosome segregation.
Use of a purified outer membrane protein F (porin) preparation of Pseudomonas aeruginosa as a protective vaccine in mice (1984)

The outer membrane protein F (porin) from the PAO1 strain of Pseudomonas aeruginosa was purified by two different methods. One procedure involved separation by column chromatography of proteins extracted from isolated outer membranes, whereas the other involved extraction from gels after slab polyacrylamide gel electrophoresis of proteins extracted from cell envelopes. Both procedures yielded protein F preparations which successfully immunized mice from subsequent challenge with the PAO1 strain. The protein F preparations contained small quantities of lipopolysaccharide (LPS). This level of LPS contamination protected immunized mice from challenge with the homologous LPS serotype strain. However, immunization of mice with protein F preparations from the PAO1 strain also afforded protection against challenge with two different LPS serotype strains. This protective ability was lost when the protein F preparation was treated with papain before use as a vaccine. These observations support the conclusion that protein F has protective ability, which is not due to LPS contamination, when given as a vaccine. After immunization with the protein F preparation, mice showed an increase in antibody titer to the purified protein F preparation by enzyme-linked immunosorbent assay. Mice were protected passively by administration of rabbit antisera raised to the protein F preparation. These results indicate that the protein F preparation elicits a specific humoral antibody response in immunized animals. Our results suggest that purified protein F has potential as an effective vaccine for P. aeruginosa.