gebhart/patrepeval huggingface dataset:
Differential expression of cytokeratin mRNA and protein in normal prostate, prostatic intraepithelial neoplasia, and invasive carcinoma. (1997)

The expression of cytokeratin (CK) mRNA for CK5, -8, -14, -16, and -19 was investigated in normal prostate, prostatic intraepithelial neoplasia (PIN) lesions, and invasive carcinoma using in situ hybridization. Protein localization was carried out in adjacent sections using immunohistochemistry and correlated with mRNA expression. Snap-frozen human prostate samples including 22 examples of normal glands, 20 cases of PIN lesions, and 12 cases of invasive carcinoma were examined. CK5 and -14 mRNA and protein were prominently expressed only in the basal cells of normal glands and PIN lesions. CK14 mRNA was absent in the luminal cells of the most of the PIN lesions but was seen at a low level in some PIN lesions. CK14 protein was not detected in any PIN lesion, suggesting that, if the cell that makes up the PIN lesions is derived from a basal cell, CK14 translation is depressed although a low level of CK14 mRNA may persist. CK8 mRNA and protein were constitutively expressed in all epithelia of normal and abnormal prostate tissues. CK19 mRNA and protein were persistently expressed in both basal and luminal cells of the tubular portion of normal glands as well as PIN lesions, but were expressed heterogeneously in both basal and luminal cells of normal alveoli. CK16 mRNA was expressed in a similar pattern as CK19, but CK16 protein was not detected either in normal or in abnormal prostate tissues. In conclusion, the expression of CK19 in PIN lesions is similar to its tubular expression and would support an origin of PIN lesions from this structure rather than the alveolar portion of the glands. The similar cytokeratin expression between PIN lesions and invasive carcinoma further supports the concept that PIN is a precursor lesion of invasive carcinoma.
Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiscodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissolutaSarath P. Gunasekera, Malika Gunasekera, Ross E. Longley, and Gayle K. SchulteCite this: J. Org. Chem. 1990, 55, 16, 4912–4915Publication Date (Print):August 1, 1990Publication History Published online1 May 2002Published inissue 1 August 1990https://pubs.acs.org/doi/10.1021/jo00303a029https://doi.org/10.1021/jo00303a029research-articleACS PublicationsRequest reuse permissionsArticle Views1350Altmetric-Citations306LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Anti-CD137 monoclonal antibody promotes the direct anti-tumor effect mediated by peripheral blood-derived human dendritic cells in vitro. (2004)

CD137, a costimulatory factor of TNFR family, is expressed on activated T cells and freshly isolated mouse dendritic cells (DCs). To date, there are only limited data dealing with the expression and the effect of CD137 on human DCs. We report in this work that CD137 can coexpress with CD137L on immature peripheral blood-derived human DCs (9.77%). The mature DCs stimulated by LPS showed a much higher level of CD137 expression (36.06%). Ligation of CD137 on the surface of DCs with anti-CD137 monoclonal antibody (mAb) could enhance the direct anti-tumor effect mediated by human DCs in vitro. The agonistic anti-CD137 mAb was able to elevate by about 20% of the DC-mediated inhibition of tumor growth in five tumor cell lines. These results indicate that the appliance of anti-CD137 mAb might be used as a new strategy for tumor immunotherapy.
Women's body image: the nurse's role in promotion of self-acceptance. (1993)

Women face criticism regarding their bodies from childhood to old age. Overt and covert messages demand that all women seek the ever-changing "ideal" body through a variety of costly, ineffective, and often dangerous means. As these demands are internalized, healthy women may develop a negative body image and a damaged sense of self. Nurses can promote peace between mind and body through the nursing process, role modeling, and community involvement. Body image should be assessed, particularly during vulnerable periods, such as adolescence, pregnancy, postpartum, and menopause. Planning, intervention, and evaluation should focus on self-acceptance and emotional and physical well-being, rather than on changing one's appearance.
GCN-GAN: A Non-linear Temporal Link Prediction Model for Weighted Dynamic Networks (2019)

In this paper, we generally formulate the dynamics prediction problem of various network systems (e.g., the prediction of mobility, traffic and topology) as the temporal link prediction task. Different from conventional techniques of temporal link prediction that ignore the potential non-linear characteristics and the informative link weights in the dynamic network, we introduce a novel non-linear model GCN-GAN to tackle the challenging temporal link prediction task of weighted dynamic networks. The proposed model leverages the benefits of the graph convolutional network (GCN), long short-term memory (LSTM) as well as the generative adversarial network (GAN). Thus, the dynamics, topology structure and evolutionary patterns of weighted dynamic networks can be fully exploited to improve the temporal link prediction performance. Concretely, we first utilize GCN to explore the local topological characteristics of each single snapshot and then employ LSTM to characterize the evolving features of the dynamic networks. Moreover, GAN is used to enhance the ability of the model to generate the next weighted network snapshot, which can effectively tackle the sparsity and the wide-value-range problem of edge weights in real-life dynamic networks. To verify the model's effectiveness, we conduct extensive experiments on four datasets of different network systems and application scenarios. The experimental results demonstrate that our model achieves impressive results compared to the state-of-the-art competitors.
[The role of fibrinogen in the pathogenesis of artherosclerosis and the mechanisms of its action]. (1996)

On rabbit artherosclerosis (AS) model induced by feeding high-cholesterol, we found that the level of plasma fibrinogen (Fg) was increased early. There was a positive correlation between the level of plasma Fg and cholesterol. By means of immunohistology analysis in vascular AS plaque, it was found that Fg and its degradation products were diffusely distributed beneath endothelium and in vascular matrix. Fg itself and its soluble metabolic products did not stimulate the proliferation of cultured vascular smooth muscle cell (SMC), but insoluble fibrin (Fb) converted from Fg stimulated SMC growth, collegen synthesis, intracellular cholesterol accumulation and endothelin release in a dose-dependent manner. In addition, Fg inhibited NO synthesis. The results suggest that Fb is an important pathogenetic factor of AS. Our studies also showed that the effect of Fb on SMC growth was dependent on extracellular Ca2+ and was mediated by protein kinase C pathway.
Time-Related Differences in the Physical Property Profiles of Oral Drugs (2004)

Comparisons of the calculated physicochemical properties of oral drugs launched prior to 1983 (864 drugs) and between 1983 and 2002 (329 drugs) show that mean values of lipophilicity, percent polar surface area and H-bond donor count are the same, suggesting that these are the most important oral druglike physical properties. In contrast, mean values of molecular weight and the numbers of O + N atoms, H-bond acceptors, and rotatable bonds and rings have increased in 1983-2002 drugs (by 13-29%). Analysis of the 1983-2002 oral drugs by therapy area shows that antiinfectives and nervous system drugs have the most extreme physical property profiles. Cardiovascular drugs show increasing molecular weight with year of publication, primarily a consequence of focusing on clinically proven mechanisms, with limited chemical diversity. Drug classes other than antiinfectives show comparable distributions of lipophilicity, suggesting that this property in oral drugs is important irrespective of the drug's target. The results suggest that the balance between polar and nonpolar drug properties is an important, unchanging feature of oral drug molecules.
Staphylococcal nuclease domain containing‐1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling (2014)

Staphylococcal nuclease domain containing-1 (SND1) is overexpressed in human hepatocellular carcinoma (HCC) patients and promotes tumorigenesis by human HCC cells. We now document that SND1 increases angiotensin II type 1 receptor (AT1R) levels by increasing AT1R mRNA stability. This results in activation of ERK, Smad2 and subsequently the TGFβ signaling pathway, promoting epithelial-mesenchymal transition (EMT) and migration and invasion by human HCC cells. A positive correlation was observed between SND1 and AT1R expression levels in human HCC patients. Small molecule inhibitors of SND1, alone or in combination with AT1R blockers, might be an effective therapeutic strategy for late-stage aggressive HCC.
Genome sequence of Yersinia pestis, the causative agent of plague (2001)

The Gram-negative bacterium Yersinia pestis is the causative agent of the systemic invasive infectious disease classically referred to as plague, and has been responsible for three human pandemics: the Justinian plague (sixth to eighth centuries), the Black Death (fourteenth to nineteenth centuries) and modern plague (nineteenth century to the present day). The recent identification of strains resistant to multiple drugs and the potential use of Y. pestis as an agent of biological warfare mean that plague still poses a threat to human health. Here we report the complete genome sequence of Y. pestis strain CO92, consisting of a 4.65-megabase (Mb) chromosome and three plasmids of 96.2 kilobases (kb), 70.3 kb and 9.6 kb. The genome is unusually rich in insertion sequences and displays anomalies in GC base-composition bias, indicating frequent intragenomic recombination. Many genes seem to have been acquired from other bacteria and viruses (including adhesins, secretion systems and insecticidal toxins). The genome contains around 150 pseudogenes, many of which are remnants of a redundant enteropathogenic lifestyle. The evidence of ongoing genome fluidity, expansion and decay suggests Y. pestis is a pathogen that has undergone large-scale genetic flux and provides a unique insight into the ways in which new and highly virulent pathogens evolve.
Electromagnetic Energy Transmission and Radiation (1960)

This book develops a consistent macroscopic theory of electromagnetism and discusses the relation between circuit theory and filed theory. The theory is developed in successive steps from the Lorentz force, the integral form of Maxwell's equations in free space, and suitable macroscopic models of polarized and magnetized matter. It covers the electromagnetism of moving bodies and the process of electromechanical energy conversion; introduces a power-series technique for analyzing quasi-static fields and quasi-stationary systems; it emphasizes the synthesis of fields as opposed to the analysis of fields. Presented in an appendix, the reader will also find, the four-dimensional relativistic formulation of macroscopic electrodynamics.
Color Atlas of Clinical Hematology, Third Edition (2001)

The third edition of the Color Atlas of Clinical Hematology, authored by Drs. A. Victor Hoffbrand and John E. Pettit, contains 19 chapters covering the entire spectrum of hematology, including normal hematopoiesis, benign and malignant
Identification of Bruton’s tyrosine kinase as a therapeutic target in acute myeloid leukemia (2013)

Bruton's tyrosine kinase (BTK) is a cytoplasmic protein found in all hematopoietic cell lineages except for T cells. BTK mediates signaling downstream of a number of receptors. Pharmacologic targeting of BTK using ibrutinib (previously PCI-32765) has recently shown encouraging clinical activity in a range of lymphoid malignancies. This study reports for the first time that ibrutinib inhibits blast proliferation from human acute myeloid leukemia (AML) and that treatment with ibrutinib significantly augmented cytotoxic activities of standard AML chemotherapy cytarabine or daunorubicin. Here we describe that BTK is constitutively phosphorylated in the majority of AML samples tested, with BTK phosphorylation correlating highly with the cell's cytotoxic sensitivity toward ibrutinib. BTK-targeted RNAi knockdown reduced colony-forming capacity of primary AML blasts and proliferation of AML cell lines. We showed that ibrutinib binds at nanomolar range to BTK. Furthermore, we showed ibrutinib's antiproliferative effects in AML are mediated via an inhibitory effect on downstream nuclear factor-κB survival pathways. Moreover, ibrutinib inhibited AML cell adhesion to bone marrow stroma. Furthermore, these effects of ibrutinib in AML were seen at comparable concentrations efficacious in chronic lymphocytic leukemia. These results provide a biological rationale for clinical evaluation of BTK inhibition in AML patients.
High-field (5 T) pulsed superconducting dipole magnet (1974)

The paper is an account of the design, construction and testing of a pulsed superconducting dipole magnet of novel design known as AC4. It represents a stage in the development of very-high-field magnets for possible use in a super-high-energy proton synchrotron. Though the magnet does not quite attain the necessary field homogeneity, the extensive tests reported here provide confidence and much relevant information for future designs using saturated iron. From electrical measurements of total losses for unidirectional and bidi rectional pulsing, an estimate can be made of the contribution from the iron yoke and shows that the hysteretic losses in the superconductor are about as expected.
Wireless LAN location-sensing for security applications (2003)

This paper considers the problem of using wireless LAN location-sensing for security applications. Recently, Bayesian methods have been successfully used to determine location from wireless LAN signals, but such methods have the drawback that a model must first be built from training data. The introduction of model error can drastically reduce the robustness of the location estimates and such errors can be actively induced by malicious users intent on hiding their location. This paper provides a technique for increasing robustness in the face of model error and experimentally validates this technique by testing against unmodeled hardware, modulation of power levels, and the placement of devices outside the trained workspace. Our results have interesting ramifications for location privacy in wireless networks.
The bonding of protective films of amorphic diamond to titanium (1992)

Films of amorphic diamond can be deposited from laser plasma ions without the use of catalysts such as hydrogen or fluorine. Prepared without columnar patterns of growth, the layers of this material have been reported to have ‘‘bulk’’ values of mechanical properties that have suggested their usage as protective coatings for metals. Described here is a study of the bonding and properties realized in one such example, the deposition of amorphic diamond on titanium. Measurements with Rutherford backscattering spectrometry and transmission electron microscopy showed that the diamond coatings deposited from laser plasmas were chemically bonded to Ti substrates in 100–200-Å-thick interfacial layers containing some crystalline precipitates of TiC. Resistance to wear was estimated with a modified sand blaster and in all cases the coating was worn away without any rupture or deterioration of the bonding layer. Such wear was greatly reduced and lifetimes of the coated samples were increased by a factor of better than 300 with only 2.7 μm of amorphic diamond.
Implementing a STARI chip (2002)

STARI is a high-speed signaling technique that uses both synchronous and self-timed circuits. To demonstrate STARI, a chip has been fabricated using the MOSIS 2/spl mu/ CMOS process. In a simple test fixture, it operates at data rates of 120 Mbits/sec over a pair of wires. Because STARl uses both synchronous and self-timed circuits, it provides an opportunity to compare these two design methods. The synchronous circuits of the STARI chip achieve rates of operation two to three times those of the self-timed circuits. However, the self-timed FIFO in the receiver provides robust compensation for clock skew that could not be achieved with synchronous circuitry alone. Thus, the STARI chip demonstrates advantages of combining these two design techniques.
Proceedings of the 18th annual ACM symposium on User interface software and technology (2005)

It is our pleasure to welcome you to Seattle for UIST 2005, the Eighteenth Annual ACM Symposium on User Interface Software and Technology. UIST 2005 continues in the tradition of being the premier forum for presentation of research innovations in the software and technology of human-computer interfaces. Sponsored by ACM's special interest groups on computer-human interaction (SIGCHI) and computer graphics (SIGGRAPH), UIST brings together researchers and practitioners from diverse areas that include traditional graphical & web user interfaces, tangible & ubiquitous computing, virtual & augmented reality, multimedia, new input & output devices, and CSCW. The intimate size, the single track, and comfortable surroundings make this symposium an ideal opportunity to exchange research results and implementation experiences.The call for papers attracted 158 full paper and TechNote submissions from 14 countries. The program committee accepted 30 of them (19%) that cover a variety of exciting topics, including mobile, physical, and voice interfaces, mouse & touch screen interaction, customization, and projector-based systems. In addition, the program includes a keynote from Gary Starkweather on personal computing in the 21st Century and two invited surveys by Susan Dray and Ken Goldberg on ethnography and the design of networked, interactive artworks, respectively. Posters, demos, and our third annual Doctoral Consortium will complete the program. You can find these contributions in the UIST conference companion, which is distributed at the conference. The UIST proceedings continue to be prepared in color and we hope that they serve as a valuable resource for researchers and practitioners. We have supplemented the proceedings with a DVD containing videos as appropriate for the papers, TechNotes, posters and demonstrations.
Creating molecular barriers to acute platelet deposition on damaged arteries with reactive polyethylene glycol (1998)

We report here a novel method for blocking acute platelet deposition at the site of vessel injury by molecularly masking thrombogenic vascular wall proteins with covalently attached polyethylene glycol (PEG). To evaluate this technique, blood containing 111In-labeled platelets was perfused over damaged human placental arteries for 2 min at a wall shear rate of 200 s-1. Denuded vessel segments were incubated for 30, 15, 5, and 1 min with a solution of either reactive PEG-diisocyanate (PEG-ISO) or nonreactive PEG-dihydroxyl (PEG-OH). Vessels treated with PEG-ISO for 1 min exhibited 87 +/- 12% less platelet deposition (p < 0.01) than untreated control vessels, and this reduction did not vary significantly among treatment times, indicating that this reaction occurs rapidly enough to be clinically applicable. To investigate the duration of this thrombotic barrier, denuded pig carotid arteries were treated with reactive PEG-ISO for 1 min, perfused with plasma for 30 min, and then perfused with blood containing radiolabeled platelets. PEG-ISO-treated arteries exhibited 84 +/- 9% less platelet deposition (p < 0.05) than untreated controls. These data demonstrate that damaged arterial surfaces can be rendered resistant to platelet deposition after short contact periods with reactive PEG. Molecular PEG barriers ultimately might find application following vascular procedures to sterically inhibit blood cell interaction with damaged vascular surfaces.
An efficient gradient method based on perturbation analysis and the batch means method (1993)

Abstract In this study, we want to develop an efficient optimization algorithm based on Perturbation Analysis (PA) and compare the performance of PA with the traditional Finite Difference (FD) gradient method. While the FD estimate is a very time‐consuming gradient method, PA is a very promising algorithm in terms of the computational time. This is the major advantage of PA over FD. In this study, we use the property that PA only requires one simulation run to obtain other advantages of PA as a gradient method. First, we deal with the problem of initialization bias for the estimate of gradients of system performance. Second, we compare the efficiency of PA and FFD (which represents FD) in introducing the control variates variance reduction technique. Third, we propose a new method for determining the simulation run length at each iteration in an optimization algorithm. In the above three areas, we show that PA is better than FD. Finally, we combine PA and BM (batch means method) to obtain a more efficient gradient method, PA‐BM.
Toward HIV Eradication or Remission: The Tasks Ahead (1998)

Recent advances in the understanding of viral kinetics and drug therapies have led to the real possibility that HIV can be kept under tight control or that an infected person can be rendered totally free of virus. There are major hurdles in the way of these goals, and David Ho discusses some of the strategies being considered.
Inhibition of the Non-Mevalonate 1-Deoxy-ᴅ-xylulose-5-phosphate Pathway of Plant Isoprenoid Biosynthesis by Fosmidomycin (1998)

Abstract Various bacterial and plastidic plant terpenoids are synthesized via the non-mevalonate1-deoxy-ᴅ-xylulose-5-phosphate (DOXP) pathway. The antibiotic and herbicidal compound fosmidomycin is known to inhibit growth of several bacteria and plants, but so far its mode of action was unknown. Here we present data which demonstrate that the DOXP pathway of isoprenoid biosynthesis is efficiently blocked by fosmidomycin. The results point to the DOXP reductoisom erase as the probable target enzyme of fosmidomycin.