gebhart/patrepeval huggingface dataset:
Substrate-site selective growth of aligned carbon nanotubes (2000)

We report highly substrate-site selective growth of carbon nanotubes by chemical vapor deposition from precursors of ferrocene and xylene mixtures. The technique allows us to grow well-aligned multiwalled carbon nanotubes preferentially on the SiO2 regions of patterned SiO2/Si substrates prepared by conventional lithography. This eliminates the catalyst predeposition step in the fabrication process. This simple approach may also be applied to build large-scale networks of organized nanotubes on planar substrates.
Innate Immune Mechanisms Dominate Elimination of Adenoviral Vectors Following In Vivo Administration (1997)

To evaluate the contribution of the innate immune component of host defense in clearing the genome of adenovirus (Ad) vectors following in vivo administration, the Ad vectors AdCMV.beta gal (expressing beta-galactosidase) or AdCMV.Null (expressing no gene) were administered intravenously to immunocompetent or immunodeficient mice, and the amount of vector genome was quantified in the liver. Strikingly, 90% of vector DNA was eliminated within 24 hr. There was no increase in vector DNA in other tissues over this period, suggesting that rapid clearance of vector genome resulted from local degradation. After 24 hr, vector elimination was slow, with only 9% of the initial amount of vector genome cleared over the subsequent 3 weeks. Importantly, early phase (0-24 hr) elimination of vector DNA was independent of the transgene and similar in immunocompetent and nude animals. These observations suggest two phases of Ad vector elimination: a previously recognized late, immune-related elimination, and the early, innate immune elimination described in the present study. The early phase of vector loss is, by far, the dominant mechanism, an observation that has implications in developing strategies to maintain persistent expression of the newly transferred gene following in vivo gene therapy.
Recent Advances in Inorganic Solid Electrolytes for Lithium Batteries (2014)

The review presents an overview of the recent advances in inorganic solid lithium ion conductors, which are of great interest as solid electrolytes in all-solid-state lithium batteries. It is focused on two major categories: crystalline electrolytes and glass-based electrolytes. Important systems such as thio-LISICON Li10SnP2S12, garnet Li7La3Zr2O12, perovskite Li3xLa(2/3)-xTiO3, NASICON Li1.3Al0.3Ti1.7(PO4)3 and glass-ceramic xLi2S•(1-x)P2S5 and their progress are described in great detail. Meanwhile, the review discusses different on-going strategies on enhancing conductivity, optimizing electrolyte/electrode interface and improving cell performance.
Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine. (1990)

smg p21A and -B are small GTP-binding proteins that share putative effector and consensus C-terminal sequences with ras p21 proteins. In the present report, we showed that human platelet smg p21B became labeled when intact platelets were incubated with exogenous [3H]mevalonolactone and when a purified preparation of smg p21B was incubated with bovine brain membranes and S-adenosyl-L-[methyl-3H]methionine. In addition, we demonstrated by gas chromatography/mass spectrometry that treatment of smg p21B with Raney nickel released a geranylgeranyl moiety in a molar ratio of about 1:1. In contrast, treatment of smg p21B with NH2OH or KOH yielded no evidence for the presence of a palmitoyl thioester. Extensive digestion of smg p21B with Achromobacter protease I yielded two C-terminal tripeptides that contained serine and cysteine in a molar ratio of 2:1. Both peptides were modified by a thioether-linked geranylgeranyl group. One of the peptides comigrated with a 3H-labeled proteolytic product of methylated smg p21B on reverse-phase HPLC and this peptide appeared at the same retention time as that of the other peptide after being treated with KOH. Since the cDNA-predicted C-terminal sequence of smg p21B contains a unique Ser-Ser-Cys peptide within its C-terminal domain, -Lys-Lys-Ser-Ser-Cys-Gln-Leu-Leu184, these results indicate that smg p21B is posttranslationally modified by geranylgeranylation of Cys-181 and suggest that further modifications cause proteolytic removal of the three predicted C-terminal amino acids followed by partial methylation of the cysteinyl carboxyl group.
Lessons from next-generation sequencing analysis in hematological malignancies (2013)

Next-generation sequencing has led to a revolution in the study of hematological malignancies with a substantial number of publications and discoveries in the last few years. Significant discoveries associated with disease diagnosis, risk stratification, clonal evolution and therapeutic intervention have been generated by this powerful technology. As part of the post-genomic era, sequencing analysis will likely become part of routine clinical testing and the challenge will ultimately be successfully transitioning from gene discovery to preventive and therapeutic intervention as part of individualized medicine strategies. In this report, we review recent advances in the understanding of hematological malignancies derived through genome-wide sequence analysis.
Design and realization of an all d-wave dc π-superconducting quantum interference device (2000)

The predominantly dx2−y2-pairing symmetry in most high-Tc superconductors provides the opportunity to fabricate Josephson junction circuits in which part of the junctions are biased by a phase difference of the superconducting order parameter of π. We present fabrication and measurements of an all high-Tc dc superconducting quantum interference device (dc SQUID) realized with thin-film technology, of which the Josephson junctions consist of one standard junction and one junction with a π-phase shift. The characteristics of the π-SQUID are compared with the properties of a standard high-Tc SQUID.
Enzymic Production of Sweet Stevioside Derivatives: Transglucosylation by Glucosidases. (1991)

For the purpose of improving sweetness and a further study on the structure-sweetness relationship of steviol glycosides, transglycosylation of stevioside by a variety of commercial glucosidases was investigated. It was revealed that two a-glucosidases gave glucosylated products. Transglucosylation of stevioside by Pullulanase and pullulan exclusively afforded three products, 13-0-[/J-maltotriosyl-(1 -2)-^-D-glucosyl]-19-O-i?-D-glucosyl-steviol (1), 13-0-[j?-maltosyl-(l -2)-/?-D-glucosyl>19-O-j?-
Recognition of guanine and adenine in DNA by cytosine and thymine containing peptide nucleic acids (PNA) (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRecognition of guanine and adenine in DNA by cytosine and thymine containing peptide nucleic acids (PNA)Michael Egholm, Peter E. Nielsen, Ole Buchardt, and Rolf H. BergCite this: J. Am. Chem. Soc. 1992, 114, 24, 9677–9678Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/ja00050a068https://doi.org/10.1021/ja00050a068research-articleACS PublicationsRequest reuse permissionsArticle Views1179Altmetric-Citations224LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
VSD2014: A dataset for violent scenes detection in hollywood movies and web videos (2015)

In this paper, we introduce a violent scenes and violence-related concept detection dataset named VSD2014. It contains annotations as well as auditory and visual features of Hollywood movies and user-generated footage shared on the web. The dataset is the result of a joint annotation endeavor of different research institutions and responds to the real-world use case of parental guidance in selecting appropriate content for children. The dataset has been validated during the Violent Scenes Detection (VSD) task at the MediaEval benchmarking initiative for multimedia evaluation.
Purification and properties of a megakaryocyte stimulatory factor present both in the serum-free conditioned medium of human embryonic kidney cells and in thrombocytopenic plasma. (1987)

Megakaryocyte stimulatory factor (MSF) has been purified to homogeneity (7.5 X 10(5)-fold) from serum-free conditioned medium obtained from cultured human embryonic kidney cells and to near homogeneity (1.44 X 10(7)-fold) from thrombocytopenic rabbit plasma. MSF activity from either source was assayed by its ability to enhance the rate of synthesis of platelet factor 4-like proteins in a rat promegakaryoblast cell line. The 125I-labeled factor prepared from human embryonic kidney cell conditioned medium is homogeneous as judged by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and isoelectric focusing in the presence of 9.2 M urea. MSF obtained from the above source is an acidic protein (pI = 5.1) with an Mr = 15,000 which stimulates platelet factor 4-like protein synthesis in rat promegakaryoblast cells by as much as 7-fold, and exhibits half-maximal activity at a concentration of 0.8 pM. MSF was also purified from thrombocytopenic rabbit plasma by a nearly identical isolation procedure, and 125I-labeled factor prepared from this source also possessed an Mr = 15,000. MSF exhibited no biologic activity corresponding to other known hemopoietic growth factors, and appears to be specific for the megakaryocyte lineage.
Correlation of leukemogenic potential of murine retroviruses with transcriptional tissue preference of the viral long terminal repeats (1987)

Recombination studies have established that retroviral long terminal repeats (LTRs) are important genetic determinants of the viral capacity to induce hematopoietic tumors and to specify the type of cell making up the tumor. Plasmids containing LTRs of several murine leukemia viruses linked to the chloramphenicol acetyltransferase gene were tested in transient assays to measure relative rates of transcriptional activity in different types of hematopoietic cells. LTRs of the thymomagenic viruses SL3-3, Moloney leukemia virus, and a Moloney mink cell focus-forming virus all expressed to higher levels than other LTRs in T-lymphocyte cell lines. Conversely, the LTRs of Friend leukemia virus and a polycythemic spleen focus-forming virus expressed to higher levels than other LTRs in erythroleukemia cells. The LTR of nonleukemogenic Akv virus induced a relatively low level of activity compared with the others in all cells tested. Thus the relative level of LTR-driven expression in various types of cells corresponds to the type of tumor caused by the intact virus in vivo. These results provide direct evidence that the tissue specificity of the transcriptional activity of LTRs plays a critical role in determining the target cell for retroviral oncogenesis.
Correction for partial volume effects in PET: principle and validation. (1998)

The PVC algorithm allows the correction for PVEs simultaneously in all identified brain regions, independent of tracer levels.
Catalytic Subunit of Protein Kinase A Caged at the Activating Phosphothreonine (2002)

Caged reagents are photoactivatable molecules with applications in biological research. While a great deal of work has been carried out on small caged molecules, less has been done on caged macromolecules, such as proteins. Caged proteins would be especially useful in signal transduction research. Since most proteins involved in cell signaling are regulated by phosphorylation, a means to cage phosphorylated proteins would be generally applicable. Here we show that the catalytic subunit of protein kinase A can be activated by thiophosphorylation at Thr-197. The modified protein can then be caged with 4-hydroxyphenacyl bromide to yield a derivative with a specific catalytic activity that is reduced by approximately 17-fold. Upon photolysis at near UV wavelengths, an approximately 15-fold increase in activity is observed, representing an approximately 85-90% yield of uncaged product with a quantum yield phi(P) = 0.21. Because protein kinases belong to a superfamily with structurally related catalytic domains, the protein chemistry demonstrated here should be applicable to a wide range of signaling proteins.
Small dual-frequency microstrip antenna with crossslot (1997)

A new design of single-feed, reduced-size dual-frequency rectangular microstrip antenna with a cross slot of equal length is presented. The frequency ratio of the two operating frequencies is mainly determined by the aspect ratio of the rectangular patch, and the reduction in the two operating frequencies is achieved by cutting a cross slot in the microstrip patch. Details of the experimental results for such a design are presented and discussed.
Alpha-helix stabilization by natural and unnatural amino acids with alkyl side chains. (1991)

Knowledge of the role of individual side chains in forming different secondary structures such as the alpha-helix would be useful for prediction of protein structure from sequence or de novo protein design. Experimental and theoretical studies on natural and synthetic peptides and proteins indicate that individual side chains differ in their helix-forming potential. Four aliphatic side chains occur in the standard complement of amino acids: alanine and leucine are helix stabilizing, whereas isoleucine and valine are weakly destabilizing. We have synthesized a series of helical peptides containing unnatural aliphatic side chains having two to four carbons to explore some of the factors involved in alpha-helix stabilization and the basis for selection of the natural set. We find that linear side chains with two, three, or four carbons are as strongly helix stabilizing as the single methyl in alanine and that all linear side chains are stronger helix promoters than leucine. In addition, a t-butyl side chain is significantly more helix destabilizing than the sec-butyl side chain of isoleucine, the isopropyl side chain of valine, or even the unrestricted side chain of glycine. These results provide experimental evidence that restriction in conformational freedom of a side chain imposed by alpha-helix formation is a major component of the role of a side chain in stabilizing helical structure.
Concise dictionary of biomedicine and molecular biology (1997)

Rapid advances in science, medicine, and molecular biology have created a large amount of new information on biomedicine and molecular biology. Keeping up with the latest information can become a cumbersome task for professionals and students working in these fields. Updated to include new terminology and accurate characterizations of previously ex
Product review on the JE vaccine IXIARO (2015)

Japanese encephalitis virus, as the most important vaccine-preventable cause of viral encephalitis in Asia, is estimated to cause over 68,000 clinical cases yearly. In endemic areas, most Japanese encephalitis infections occur in children younger than 10 y and clinical manifestation of this disease is critical, because there is no effective treatment available. As JEV infections are regarded as one of the most serious viral causes of encephalitis and mass immunization programmes are generally recommended for residents in endemic areas, a safe and effective JEV vaccine was needed to protect them as well as others at risk. Due to the safety concerns with the mouse brain derived vaccine, second generation vaccines against JE produced in cell culture like Vero cells were developed. IXIARO® is a purified, inactivated aluminum-adjuvanted JE vaccine, based on the SA14-14-2 virus strain, and is available in North America, Europe, Canada, Switzerland, Singapore, Hong Kong and Israel as well as in Australia & New Zealand (as JESPECT®).The safety, tolerability and immunogenicity profile of IXIARO® is well established through a number of clinical studies comparing IXIARO® with placebo as well as mouse brain derived vaccine. Recent data show that the global incidence of JE remains substantial, especially young children in endemic areas are most susceptible. As vaccination is the most feasible, reliable and cost effective tool for JE control, IXIARO® with confirmed excellent safety profile is highly recommendable, in particular for vaccination of children at risk. The European Commission as well as the FDA approved the extension of indication of IXIARO® to the pediatric segment (2 months of age and older) based on these data.
High Prevalence ofDemodexin Eyelashes with Cylindrical Dandruff (2005)

The modified sampling and counting method showed that the prior controversy regarding Demodex has resulted from miscounting and confirmed that lashes with CD are pathognomonic for ocular Demodex infestation. Lid hygiene with shampoo reduces Demodex counts but does not eradicate the mites.
Cooperative Transport of Brownian Particles (1995)

We consider the collective motion of finite-sized, overdamped Brownian particles (e.g., motor proteins) in a periodic potential. Simulations of our model have revealed a number of novel cooperative transport phenomena, including (i) the reversal of direction of the net current as the particle density is increased and (ii) a very strong and complex dependence of the average velocity on both the size and the average distance of the particles.
Cytokines levels, Severity of acute mucositis and the need of PEG tube installation during chemo-radiation for head and neck cancer - a prospective pilot study (2010)

These preliminary results, indicating a correlation between IL-6 and IL-8 serum levels and severity of mucositis and a need for a PEG tube installation, justify a large scale study.
Laser production of supersonic metal cluster beams (1981)

Cold beams of metal clusters are produced by combining a laser vaporization technique with pulsed supersonic nozzle technology. (AIP)
青梅煮酒，英雄是谁？——国产四天王VS国外四名机 (2001)

外形 Ｖ９９８＋是摩托罗拉的一款经典机型。尽管出道已久，依然有众多的痴迷者。而作为波导广告代言人的ＣｏＣｏ李玟，倾情演绎“新视窗，新生活”，将Ｓ１０００的卖点诠释得相当经典，深入人心。 Ｖ９９８＋继承了Ｖ９９８轻巧、折叠的特点，圆润的流线，环绕的金属光边露出盈盈笑意，让人不知不觉沉醉其中；Ｓ１０００少了几分Ｖ９８８＋的妩媚，银白色的外壳，浓烈的金属感，平添了一分阳刚之气。 Ｖ９９８＋独特的翻盖式显示屏，信息查阅方便；而Ｓ１０００通过新视窗直接观看屏幕，结合两个快捷键，不用翻盖就查阅短消息，让你享受精明快捷之感。Ｖ９８８＋按键稍硬，且无背光灯设计；Ｓ１０００按键柔滑，弹性适中，指感较好。同时黄色
Intrapulmonary Delivery of Tumor Necrosis Factor Agonist Peptide Augments Host Defense in Murine Gram-Negative Bacterial Pneumonia (1998)

Tumor necrosis factor alpha (TNF) has been shown to be an essential cytokine mediator of innate immunity in Klebsiella pneumonia. Recently, a TNF agonist peptide consisting of the 11-amino-acid TNF binding site (TNF70-80) has been shown to possess many of the leukocyte-activating properties of TNF without the associated toxicity when administered locally or systemically. Given the beneficial effects of TNF in gram-negative pneumonia, we hypothesize that the intratracheal (i.t.) administration of TNF70-80 would augment lung innate immunity in mice challenged with intrapulmonary Klebsiella pneumoniae. The administration of TNF70-80 i.t. to CBA/J mice 7 days prior to, but not concomitantly with, the i.t. delivery of 3 x 10(3) CFU of K. pneumoniae resulted in a marked increase in survival compared to that of animals receiving a control peptide i.t. In addition, pretreatment with TNF70-80 resulted in improved bacterial clearance, which occurred in association with enhanced lung myeloperoxidase activity (as a measure of lung polymorphonuclear leukocyte influx), and increased expression of the important activating cytokines TNF, macrophage inflammatory protein-2, interleukin-12, and gamma interferon compared that for animals receiving control peptide. Finally, the administration of TNF70-80 intraperitoneally resulted in enhanced rather than decreased lethality of Klebsiella pneumonia compared to that for animals receiving either TNF70-80 or control peptide i.t. Our studies suggest that the intrapulmonary, but not systemic, administration of the TNF agonist peptide may serve as an important immunoadjuvant in the treatment of murine Klebsiella pneumonia.
Imaging mid-ocean ridge transitions with satellite gravity (1994)

Research Article| February 01, 1994 Imaging mid-ocean ridge transitions with satellite gravity Christopher Small; Christopher Small 1Scripps Institution of Oceanography, La Jolla, California 92093 Search for other works by this author on: GSW Google Scholar David T. Sandwell David T. Sandwell 1Scripps Institution of Oceanography, La Jolla, California 92093 Search for other works by this author on: GSW Google Scholar Author and Article Information Christopher Small 1Scripps Institution of Oceanography, La Jolla, California 92093 David T. Sandwell 1Scripps Institution of Oceanography, La Jolla, California 92093 Publisher: Geological Society of America First Online: 02 Jun 2017 Online ISSN: 1943-2682 Print ISSN: 0091-7613 Geological Society of America Geology (1994) 22 (2): 123–126. https://doi.org/10.1130/0091-7613(1994)022<0123:IMORTW>2.3.CO;2 Article history First Online: 02 Jun 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Search Site Citation Christopher Small, David T. Sandwell; Imaging mid-ocean ridge transitions with satellite gravity. Geology 1994;; 22 (2): 123–126. doi: https://doi.org/10.1130/0091-7613(1994)022<0123:IMORTW>2.3.CO;2 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyGeology Search Advanced Search Abstract Gravity maps derived from satellite altimeter measurements provide unprecedented me. Dium-resolution coverage of sparsely surveyed mid-ocean ridges in the southern oceans. A spectral analysis of 76 000 km of coincident shipboard and satellite gravity measurements shows that satellite altimeters can accurately resolve features with half-wavelengths as short as 13 km. The coverage and resolution of these gravity data allow us to determine accurately both the location of poorly charted ridge axes and the variation in axial anomaly character along the ridge axis, although their detailed morphology is not resolved. The results of this study support earlier studies that showed a transition from spreading-rate-dependent axial gravity lows to rate-independent axial highs with increasing spreading rate. Four such transitions are imaged on the Southeast Indian Ridge and Pacific Antarctic Ridge. We expect that these transitions are the result of a temperature-sensitive threshold phenomenon and may be influenced by nearby hot spots. This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not have access to this content, please speak to your institutional administrator if you feel you should have access.