gebhart/patrepeval huggingface dataset:
Online Learning for Group Lasso (2010)

We develop a novel online learning algorithm for the group lasso in order to efficiently find the important explanatory factors in a grouped manner. Different from traditional batch-mode group lasso algorithms, which suffer from the inefficiency and poor scalability, our proposed algorithm performs in an online mode and scales well: at each iteration one can update the weight vector according to a closed-form solution based on the average of previous subgradients. Therefore, the proposed online algorithm can be very efficient and scalable. This is guaranteed by its low worst-case time complexity and memory cost both in the order of O(d), where d is the number of dimensions. Moreover, in order to achieve more sparsity in both the group level and the individual feature level, we successively extend our online system to efficiently solve a number of variants of sparse group lasso models. We also show that the online system is applicable to other group lasso models, such as the group lasso with overlap and graph lasso. Finally, we demonstrate the merits of our algorithm by experimenting with both synthetic and real-world datasets. 1.
The reactivity pattern of hemagglutinin-specific clonotypes from mice immunized as neonates or adults with naked DNA (1998)

In contrast to adult mice immunized with influenza A virus strain WSN and plasmid expressing WSN hemagglutinin (HA) gene which developed primary and secondary anti-HA antibody responses, mice immunized as neonates with virus failed to produce anti-HA antibodies while those immunized with plasmid developed weak primary but strong secondary responses. Analysis of the frequency of HA-specific B clonotypes as well as their reactivity pattern (RP) showed that viral or genetic immunization of adults increased the frequency of clonotypes which exhibit broad RP. The most striking observation of our study is that immunization of neonates with plasmid leads to increased synthesis of anti-HA antibodies as well as to an increased frequency of clonotypes exhibiting an adult-like RP. In contrast, neonatal immunization with virus caused a long-lasting unresponsiveness and the few clonotypes stimulated in vitro exhibited only a monoreactive pattern. Isotype patterns of mAb are also diversified in the case of mice immunized with plasmid as neonates. Rapid replacement of neonatal with adult clonotypes may explain the significant survival of the mice immunized with plasmid and challenged 1 or 3 months later with lethal doses of virus.
Estrogens, Progesterone, and Endometrial Cancer (1993)

We conducted a case-control study to evaluate the effect of replacement estrogen use alone, and the combined effect of estrogen and progesterone use, on the risk for endometrial cancer. We studied women age 50-64 years at Group Health Cooperative of Puget Sound. We identified 172 incident cases of endometrial cancer diagnosed during the years 1979-1989, and controls of similar age and duration of membership in the plan. Women who had used conjugated estrogens alone for 5 or more years were at increased risk for developing endometrial cancer compared with nonusers [adjusted rate ratio (RR) = 22.0; 95% confidence interval (CI) = 6.5-74.1]. Users of unopposed estrogens of 3-4 years' duration had a relative risk of 1.9 (95% CI = 0.4-8.7). Women who had used medroxyprogesterone acetate in combination with the estrogen therapy for 3 or more years had a risk near that of nonusers (adjusted RR = 1.3; 95% CI = 0.5-3.4) and that of users of unopposed estrogens for less than 5 years. There were insufficient women who used estrogen and progesterone together for 5 or more years to derive a separate risk estimate for these women.
Tumor necrosis factor production by human monocytes is a regulated event: induction of TNF-alpha-mediated cellular cytotoxicity by endotoxin. (1986)

Expression of cellular cytotoxicity by monocytes or macrophages has been conceived as an induced function secondary to collaboration in the immune response or to other agonists. However, a form of spontaneous cellular cytotoxicity by monocytes analyzed with unseparated human peripheral blood mononuclear cells (PBM) has been described by using the 6-hr 51Cr release from actinomycin D (ActD)-treated murine WEHI 164 cells, a target cell refractory to the cytotoxic effects of natural killer and cytolytic T cells. We observe that when cells are isolated under rigorously endotoxin-free conditions, there is no cytotoxicity. Inclusion of serum does not induce cellular cytotoxicity; however, cytotoxic activity is induced by the presence of as little as 1 pg/ml of bacterial lipopolysaccharide (LPS). PBM required 2 hr of preexposure to endotoxin in order to express full cytotoxic activity. We investigated the basis of the cytotoxicity of WEHI 164 cells and the effect of ActD. ActD-treated target cells are highly susceptible to the effects of TNF-alpha and TNF-beta (alpha-lymphotoxin), whereas untreated target cells were resistant. In contrast, ActD does not affect susceptibility to the cytotoxic effects of H2O2, and interleukin 1 is not cytotoxic to the target cells. With the use of a neutralizing monoclonal antibody specific for TNF-alpha, the cytotoxic activity induced by LPS greatly diminished and the amount of TNF-alpha neutralized is similar to that required for equivalent cytotoxicity. We conclude that monocytes present in human PBM are not "spontaneously" cytotoxic for ActD-treated WEHI 164 target cells, but that the reported cytotoxicity results from exposure to a level of endotoxin or endotoxin-like agonists to which the cells are exposed. The cytotoxicity is mediated mostly if not entirely by TNF-alpha, an established product of monocytes/macrophages. With the use of endotoxin-free conditions, PBM can be isolated in a cytotoxically latent state, suitable for analysis of the immunologic regulation of TNF-alpha-mediated monocyte cellular cytotoxicity.
Self-organized tantalum oxide nanopyramidal arrays for antireflective structure (2007)

A self-organized tantalum oxide nanopyramidal structure without tedious semiconductor processing is proposed in this letter. Construction of pyramid arrays with a close-packed periodicity of 200nm and a height of 200nm was achieved by the anodic alumina template method directly on the substrate. The tantalum oxide nanopyramidal structure was formed as the underlying tantalum film oxidized and localized precisely by the pore of alumina. The reflectance from the spectroscopic measurement suggests that the nanopyramidal array structures have more broadband antireflection (&amp;lt;2%) than the nanodot arrays and thin film structures.
锻造苏维埃天空的“铁幕”——记苏联防空军总司令巴季茨基 (2004)

巴维尔·巴季茨基空军元帅，是苏联著名的军事将领。曾长期担任防空军总司令。1910年6月27日。巴季茨基出生在哈尔科夫郊区的一个工人家庭。他从小身体健壮、勇敢好学，争强好胜，从不服输。1922年读完小学四年级后，巴季茨基进工厂当了钳工学徒，后来又在厂办的“镰刀和锤子”学校半工半读。
Analysis of the VMD2 Promoter and Implication of E-box Binding Factors in Its Regulation (2004)

The retinal pigment epithelium (RPE) is crucial for the normal development and function of retinal photo-receptors, and mutations in several genes that are preferentially expressed in the RPE have been shown to cause retinal degeneration. We analyzed the 5'-up-stream region of human VMD2, a gene that is preferentially expressed in the RPE and, when mutated, causes Best macular dystrophy. Transgenic mouse studies with VMD2 promoter/lacZ constructs demonstrated that a-253 to +38 bp fragment is sufficient to direct RPE-specific expression in the eye. Transient transfection assays using the D407 human RPE cell line with VMD2 promoter/luciferase reporter constructs identified two positive regulatory regions, -585 to -541 bp for high level expression and -56 to -42 bp for low level expression. Mutation of a canonical E-box located in the -56 to -42 bp region greatly diminished luciferase expression in D407 cells and abolished the bands shifted with bovine RPE nuclear extract in electrophoretic mobility shift assays. Independently a candidate approach was used to select microphthalmia-associated transcription factor (MITF) for testing because it is expressed in the RPE and associated with RPE abnormalities when mutated. MITF-M significantly increased luciferase expression in D407 cells in an E-box-dependent manner. These studies define the VMD2 promoter region sufficient to drive RPE-specific expression in the eye, identify positive regulatory regions in vitro, and suggest that MITF as well as other E-box binding factors may act as positive regulators of VMD2 expression.
Production of Microcellular Polycarbonate Using Carbon Dioxide for Bubble Nucleation (1994)

A process to produce a family of novel materials from polycarbonate, having a microcellular structure, is described. The process utilizes the high solubility of carbon dioxide in polycarbonate to nucleate a very large number of bubbles, on the order of 1 to 10 × 109 bubbles/cm3, at temperatures well below the glass transition temperature of the original, unsaturated polycarbonate. Microcellular polycarbonate foams with homogeneous microstructure and a wide range of densities have been produced. In this paper experimental results on solubility, bubble nucleation, and bubble growth in the polycarbonate-carbon dioxide system are presented, and the critical ranges of the key process parameters are established. It is shown that the bubble nucleation phenomenon in polycarbonate near the glass transition temperature is not described by classical nucleation theory.
Symbolic simulation techniques-state-of-the-art and applications (2002)

A number of different techniques of symbolic simulation in particular at the behavioral and structural rt-level are classified. The principles of the TUD Symbolic Simulator used for equivalence checking are briefly outlined. The application of the tool to property checking is demonstrated. Experimental results with input languages Esterel and C are given.
Anoxic and Ischemic Injury of Myelinated Axons in CNS White Matter: From Mechanistic Concepts to Therapeutics (1998)

White matter of the brain and spinal cord is susceptible to anoxia and ischemia. Irreversible injury to this tissue can have serious consequences for the overall function of the CNS through disruption of signal transmission. Myelinated axons of the CNS are critically dependent on a continuous supply of energy largely generated through oxidative phosphorylation. Anoxia and ischemia cause rapid energy depletion, failure of the Na(+)-K(+)-ATPase, and accumulation of axoplasmic Na+ through noninactivating Na+ channels, with concentrations approaching 100 mmol/L after 60 minutes of anoxia. Coupled with severe K+ depletion that results in large membrane depolarization, high [Na+]i stimulates reverse Na(+)-Ca2+ exchange and axonal Ca2+ overload. A component of Ca2+ entry occurs directly through Na+ channels. The excessive accumulation of Ca2+ in turn activates various Ca(2+)-dependent enzymes, such as calpain, phospholipases, and protein kinase C, resulting in irreversible injury. The latter enzyme may be involved in "autoprotection," triggered by release of endogenous gamma-aminobutyric acid and adenosine, by modulation of certain elements responsible for deregulation of ion homeostasis. Glycolytic block, in contrast to anoxia alone, appears to preferentially mobilize internal Ca2+ stores; as control of internal Ca2+ pools is lost, excessive release from this compartment may itself contribute to axonal damage. Reoxygenation paradoxically accelerates injury in many axons, possibly as a result of severe mitochondrial Ca2+ overload leading to a secondary failure of respiration. Although glia are relatively resistant to anoxia, oligodendrocytes and the myelin sheath may be damaged by glutamate released by reverse Na(+)-glutamate transport. Use-dependent Na+ channel blockers, particularly charged compounds such as QX-314, are highly neuroprotective in vitro, but only agents that exist partially in a neutral form, such as mexiletine and tocainide, are effective after systemic administration, because charged species cannot penetrate the blood-brain barrier easily. These concepts may also apply to other white matter disorders, such as spinal cord injury or diffuse axonal injury in brain trauma. Moreover, whereas many events are unique to white matter injury, a number of steps are common to both gray and white matter anoxia and ischemia. Optimal protection of the CNS as a whole will therefore require combination therapy aimed at unique steps in gray and white matter regions, or intervention at common points in the injury cascades.
Hormonal regulation of the bovine prolactin promoter in rat pituitary tumor cells. (1985)

A 1-kilobase DNA fragment containing the promoter of the bovine prolactin gene was fused to the chloramphenicol acetyltransferase gene and the activity of the promoter was assayed by transfection of the fusion gene into COS-1, HeLa, and GH3 cells. Transcription of the chloramphenicol acetyltransferase gene driven by the prolactin promoter was detected only in GH3 cells, a rat pituitary tumor cell line. Epidermal growth factor and thyroid releasing hormone produced a stimulation of transcription, and the synthetic glucocorticoid hormone dexamethasone effected an inhibition of transcription from the prolactin promoter. None of these factors significantly affected transcription of the chloramphenicol acetyltransferase gene fused to the Rous sarcoma virus promoter. Deletion of all but 250 base pairs of bovine prolactin 5'-flanking DNA had no effect, indicating that the signals sufficient for both stimulation and inhibition of transcription reside in close proximity to the promoter.
<i>In Vitro</i> Antimicrobial Activity of Stevia Rebaudiana Bertoni Leaves (2007)

Purpose: The aim of the present study was to investigate antimicrobial activity of the various extracts of Stevia rebaudiana leaves. Method: Stevia rebaudiana Bertoni leaves were extracted in water, methanol, ethyl acetate and hexane and their antimicrobial activities were examined against few selected microorganisms including B. subtilis, S. aureus, M. luteus, S. marcenscens, P. aeruginosa, B. megaterium, E. coli, P. vulgaris, Yeast, A. niger and R. oligoporus using cup plate method. Results: Water extract of Stevia leaf showed activity against B. subtilis and S. aureus only. Methanol extract gave the highest zone of inhibition against P. aeruginosa whereas minimum zone of inhibition was found against S. aureus and yeast. B. megaterium and yeast were found to be highly susceptible towards ethyl acetate and hexane extracts, respectively whereas A. niger and B. subtilis were found to be least susceptible against ethyl acetate and hexane extracts, respectively. Hexane extract showed the highest activity against yeast among the tested microorganisms. Conclusion: The study confirms the possible antimicrobial potentiality of the leaf extract of Stevia rebaudiana. Keywords: Stevia rebaudiana, antimicrobial activity, leaf extracts > Tropical Journal of Pharmaceutical Research Vol. 5 (1) 2006: pp. 557-560
Review of the evidence that pH is a determinant of nicotine dosage from oral use of smokeless tobacco (1997)

Although other factors could influence the rate of nicotine absorption from oral tobacco, manipulating tobacco pH appears to be the primary means by which the speed of nicotine absorption is determined in moist-snuff products.
Phase I Clinical Evaluation of a Neutralizing Monoclonal Antibody Against Epidermal Growth Factor Receptor in Advanced Brain Tumor Patients: Preliminary Study (2001)

High levels of growth factors and their receptors have been demonstrated in human tumors. Gliomas and meningiomas are characterized by overexpression of epidermal growth factor receptor (EGF-R). Ior egf/r3, is a neutralizing murine monoclonal antibody (MAb) against EGF-R, and was generated at the Cuban Institute of Oncology. The antibody recognizes EGF-R with high affinity, inhibiting tyrosine kinase activation. A clinical trial was conducted in brain tumor patients to evaluate toxicity, immunogenicity, and clinical benefit of escalating doses of the antibody. Nine patients with histologically confirmed gliomas or meningiomas, who had active or recurrent disease after receiving conventional treatment, received four intravenous doses of ior egf/r3. Total dosages ranged from 160 to 480 mg. As inclusion criteria, radioimmunoscintigraphy with the same MAb labeled with 99mTechnetium (99mTc) was performed. Immune response against the murine antibody was also evaluated. After four doses of ior egf/r3 MAb, no significant toxicity was found, except in one patient who developed a grade 4 allergic adverse event. This reaction was probably related with previous sensitization to the same MAb and the development of human anti-mouse antibodies (HAMA) response. Despite no major objective antitumor responses, eight patients had stable disease on the 6-month evaluation, and two patients remain alive after four years of MAb therapy.
PROLONGATION OF CARDIAC XENOGRAFT SURVIVAL BY DEPLETION OF COMPLEMENT (1993)

Complement (C) activation is thought to be critical for the hyperacute rejection of xenografts. We investigated the role of C in the rejection of discordant cardiac xenografts by studying outcome in recipients depleted of C, using a highly purified form of cobra venom factor (CVF) in both a small (guinea pig [GP]-to-rat) and large (pig-to-baboon) animal model. A single dose of 30 or 60 units CVF given i.v. to rats completely abrogated hemolytic C activity for up to 72 hr. The lack of hemolytic C activity correlated with nearly undetectable serum levels of C3. Doses of 30 U/kg daily or 60 U/kg every other day over a 7-day period sustained C depletion without morbidity or mortality. Rats receiving GP cardiac xenografts during CVF therapy had significantly prolonged xenograft survival (88 +/- 10 hr in CVF-treated rats vs. 18.6 +/- 7.2 min in control rats, P < 0.001). Rats that rejected GP xenografts at 4 days posttransplant had higher levels of anti-GP antibodies than control rats, without hemolytic C activity at rejection. This rise in xenoreactive Ig reflected an increase in circulating IgG and IgM against GP antigens recognized before transplantation. Histologic analysis of GP cardiac xenografts taken from CVF-treated rats revealed leukocyte and monocyte margination along blood vessels, beginning at 12 hr posttransplant. Progressive cell infiltration, interstitial hemorrhage, and necrosis were observed over the next 72 hr. Rejected GP xenografts showed diffuse deposition of IgM and fibrin within blood vessels but no evidence of C3 deposition. A nonspecific pattern of IgG deposition was noted. CVF was tested in baboons. Complete C depletion was achieved with a dose of 60 U/kg, and was not associated with any morbidity or mortality. Xenotransplantation of a pig heart was performed in one baboon receiving CVF, 60 U/kg/day, for 2 consecutive days. Xenograft survival was prolonged to 68 hr, compared with 90 +/- 30 min in control baboons. Lack of hemolytic activity was noted during engraftment and at rejection. Histology showed evidence of vascular rejection. Immunopathology showed diffuse deposition of IgM, fibrin, and C4, and absence of C3 or membrane attack complex. We conclude that highly purified CVF can achieve marked C depletion with minimal morbidity and no associated fatalities. CVF alone can significantly prolong discordant cardiac xenograft survival. In the GP-to-rat model, the improvement in graft survival achieved with CVF was better than with conventional immunosuppression or isolated acute antibody depletion.(ABSTRACT TRUNCATED AT 400 WORDS)
Cannabidiol in vivo blunts β‐amyloid induced neuroinflammation by suppressing IL‐1β and iNOS expression (2007)

The results of the present study confirm in vivo anti-inflammatory actions of CBD, emphasizing the importance of this compound as a novel promising pharmacological tool capable of attenuating Abeta evoked neuroinflammatory responses.
Whole-Inactivated Influenza Virus Is a Potent Adjuvant for Influenza Peptides Containing CD8+ T Cell Epitopes (2018)

Influenza peptide antigens coding for conserved T cell epitopes have the capacity to induce cross-protective influenza-specific immunity. Short peptide antigens used as a vaccine, however, often show poor immunogenicity. In this study, we demonstrate that whole-inactivated influenza virus (WIV) acts as an adjuvant for influenza peptide antigens, as shown by the induction of peptide-specific CD8<sup>+</sup> T cells in HLA-A2.1 transgenic mice upon vaccination with the influenza-M1-derived GILGFVFTL peptide (GIL), formulated with WIV. By screening various concentrations of GIL and WIV, we found that both components contributed to the GIL-specific T cell response. Whereas co-localization of the peptide antigen and WIV adjuvant was found to be important, neither physical association between peptide and WIV nor fusogenic activity of WIV were relevant for the adjuvant effect of WIV. We furthermore show that WIV may adjuvate T cell responses to a variety of peptides, using pools of either conserved wild-type influenza peptides or chemically altered peptide ligands. This study shows the potential of WIV as an adjuvant for influenza peptides. The simple formulation process and the solid safety record of WIV make this an attractive adjuvant for T cell peptides, and may also be used for non-influenza antigens.
Performance Testing of the Ratio Ground Relay on a Four-Wire Distribution Feeder (1983)

Digital fault investigations on six Pennsylvania Power and Light 12 kV distribution feeders led to the development of a prototype Ratio Ground Relay to theoretically provide better detection of broken conductor faults. Further assessment of the relay's performance was provided through analog computer tests followed by staged fault testing on an operating distribution feeder. Performance tests are described and documented. These positive test results provided the incentive to monitor the performance of the Ratio Ground Relay on several PP&L distribution feeders.
Superhydrophobic and Superoleophilic PVDF Membranes for Effective Separation of Water‐in‐Oil Emulsions with High Flux (2013)

A superhydrophobic-superoleophilic PVDF membrane is fabricated via an inert solvent-induced phase inversion for effective separation of both micrometer and nanometer-sized surfactant-free and surfactant-stabilized water-in-oil emulsions solely driven by gravity, with high separation efficiency (oil purity in filtrate after separation > 99.95 wt%) and high flux, which is several times higher than those of commercial filtration membranes and reported materials with similar permeation properties.