gebhart/patrepeval huggingface dataset:
Single‐cell analysis of intrathyroidal lymphocytes shows differential cytokine expression in Hashimoto's and Graves' disease (1997)

Most human organ-specific autoimmune diseases such as Hashimoto's thyroiditis (HT) are considered to be Th1 mediated, and a quantitative dominance of Th1 cells in thyroid infiltrates from both Graves' disease (GD) and HT affected glands has been reported. However, Th2 dominance would be expected in GD, where thyroid hyperfunction induced by stimulating antibodies predominates over tissue destruction. We have analyzed the interleukin-4 (IL-4), interferon-gamma (IFN-gamma) production by T cells at the single-cell level, both in infiltrating lymphocytes isolated from digested GD and HT thyroid glands and in derived T cell lines, by direct intracellular cytokine detection. Results showed a heterogeneous pattern of cytokine production in bulk GD infiltrates and derived T cell lines, and a similar pattern was observed in the much larger HT infiltrates. Both type 1 and type 2 cytokines were simultaneously produced by the infiltrating populations, and T cells with both patterns as well as intermediate patterns similar to Th0 cells could be detected ex vivo. However, the larger T lymphocytes, presumably activated and responsible for the autoimmune damage, predominantly produced IL-4 in GD and IFN-gamma in HT. The specificity of the Th2 responses in GD was suggested by the enrichment in IL-4 production after antigen-specific expansion of two oligoclonal T cell lines. These data show that both type 1 and type 2 cytokines are produced in the thyroid glands affected by autoimmunity and that the difference between diseases may be the effect of a functionally dominant population at a given time. This in vivo chronically activated antigen-specific population, producing type 1 or type 2 cytokines locally, may be responsible for the effect finally leading to one of the disease states.
Compilation of small ribosomal subunit RNA sequences (1988)

Footnotes to Table b) This column contains the following data, if specified by the authors:
Production of transforming growth factor beta 1 during repair of arterial injury. (1991)

Repair of arterial injury produced by balloon angioplasty leads to the formation of a neointima and a narrowing of the vascular lumen. In this study, we examined the possibility that smooth muscle cells (SMC) in injured rat carotid arteries are stimulated to produce type-1 transforming growth factor-beta (TGF-beta 1) during neointima formation in vivo. Levels of TGF-beta 1 transcripts (2.4 kb) were significantly increased within 6 h after carotid injury and reached a maximum (five to sevenfold) by 24 h. Regenerating left carotids had sustained increases in TGF-beta 1 mRNA levels (about fivefold) over the next 2 wk, during which time a substantial neointimal thickening was formed. No changes in basal TGF-beta 1 mRNA levels were found in contralateral uninjured carotids at any of the times examined. Immunohistochemical studies showed that a large majority of neointimal SMC were stained for TGF-beta 1 protein in an intracellular pattern, consistent with active TGF-beta 1 synthesis in this tissue. Neointima formation and TGF-beta 1 immunoreactivity were correlated with increases in fibronectin, collagen alpha 2(I), and collagen alpha 1(III) gene expression. Infusion of purified, recombinant TGF-beta 1 into rats with a preexisting neointima produced a significant stimulation of carotid neointimal SMC DNA synthesis. These results suggest that TGF-beta 1 plays an important role as an endogenous growth regulatory factor produced by neointimal SMC themselves during progressive neointimal thickening after balloon angioplasty.
Three-Dimensional Object Recognition Using N-Dimensional Chain Codes (1982)

Abstract : Recognition of class and aspect angle of a rigid three-dimensional object in free space is facilitated by using N-dimensional chain codes in feature space. In both radar and image recognition systems features have previously been described that are invariant to object rotation about the observer's line of sight to the object center of gravity. However, rotations about the remaining two orthogonal axes produce changes of the features and a full description of the object becomes a toroidal surface in N-dimensional feature space. N-dimensional chain codes are introduced in this paper to give a line approximation of such a surface that is easily used to identify an unknown object and to estimate its aspect angle.
Utilizing quantitative immunohistochemistry for relationship analysis of tumor microenvironment of head and neck cancer patients (2014)

Meeting abstracts Analysis of tumor-infiltrating immune cells using quantitative immunohistochemistry (IHC) has proved to be a powerful prognostic biomarker in colon cancer [[1][1], [2][2]]. Similar observations have been made in patients with oral, head and neck squamous cell carcinoma (OHNSCC),
Antibodies against a Synthetic Peptide of SagA Neutralize the Cytolytic Activity of Streptolysin S from Group A Streptococci (2002)

Virtually all group A streptococci (GAS) produce streptolysin S (SLS), a cytolytic toxin that is responsible for the beta-hemolysis surrounding colonies of the organisms grown on blood agar. SLS is an important virulence determinant of GAS, and recent studies have identified a nine-gene locus that is responsible for synthesis and transport of the toxin. SLS is not immunogenic; thus, no neutralizing antibodies are evoked during the course of natural infection. In the present study, we show that a synthetic peptide containing amino acid residues 10 to 30 of the putative SLS (SagA) propeptide [SLS(10-30)] coupled to keyhole limpet hemocyanin evoked antibodies in rabbits that completely neutralized the hemolytic activity of the toxin in vitro. Inhibition of hemolysis was reversed by preincubation of the immune serum with soluble, unconjugated peptide, indicating the specificity of the antibodies. In addition, antibodies that were affinity purified over an SLS(10-30) peptide column completely inhibited SLS-mediated hemolysis. The SLS(10-30) antisera did not opsonize group A streptococci; however, when combined with type-specific M protein antisera, the SLS antibodies significantly enhanced phagocytosis mediated by M protein antibodies. Thus, we have shown for the first time that it is possible to raise neutralizing antibodies against one of the most potent bacterial cytolytic toxins known. Our data also provide convincing evidence that the sagA gene actually encodes the SLS peptide of GAS. The synthetic peptide may prove to be an important component of vaccines designed to prevent GAS infections.
Intramuscular Pressure in the Leg and Thigh Related to Tensile Strap Force During Knee Brace Wear (1998)

The effects of a functional knee brace on intramuscular pressure in the leg and thigh were measured in eight subjects with a mean age of 32 years. Pressures in the tibialis anterior and rectus femoris muscles were recorded without a knee brace and with a brace applied with strap tensile force of 25 N, 50 N, and a force preferred by the subject. External compression caused by the brace significantly increased intramuscular pressures at rest and muscle relaxation pressure during exercise in the leg and thigh muscles. Pressure in the tibialis anterior muscle increased 3 to 10 times, to mean values between 17.5 and 41 mm Hg, depending on the tensile force of the straps used at brace application. Corresponding mean pressure values in the rectus femoris muscle were between 17.5 and 32.5 mm Hg. Mean pressures in the standing subject varied between 37 and 62 mm Hg. Our study showed that intramuscular pressure at rest and muscle relaxation pressure during exercise in the tibialis anterior and the rectus femoris muscles increased significantly in the braced limb. Local blood perfusion pressure in the supine subject decreased significantly, by 16% to 42%, in the compressed muscles.
Low-density open-cell foams in the NiTi system (2003)

It is shown that open-cell metallic foams having very low density, and that display martensite transformations required for shape memory and superelastic behavior, can be fabricated using a powder-metallurgy technique. Results are presented on experiments in which a polymeric precursor foam was coated with an equiatomic NiTi powder slurry and subsequently sintered to yield foams with relative densities as low as 0.039. Although contaminated with interstitial impurities, they displayed unambiguous calorimetric signature of the B2→B19′ transformation. The results are of considerable significance to potential applications requiring ultralightweight structures with the unusual dissipative and strain-recovery properties of NiTi shape-memory materials.
Reinforcement Learning in Continuous Time and Space (2000)

This article presents a reinforcement learning framework for continuous-time dynamical systems without a priori discretization of time, state, and action. Based on the Hamilton-Jacobi-Bellman (HJB) equation for infinite-horizon, discounted reward problems, we derive algorithms for estimating value functions and improving policies with the use of function approximators. The process of value function estimation is formulated as the minimization of a continuous-time form of the temporal difference (TD) error. Update methods based on backward Euler approximation and exponential eligibility traces are derived, and their correspondences with the conventional residual gradient, TD(0), and TD(lambda) algorithms are shown. For policy improvement, two methods-a continuous actor-critic method and a value-gradient-based greedy policy-are formulated. As a special case of the latter, a nonlinear feedback control law using the value gradient and the model of the input gain is derived. The advantage updating, a model-free algorithm derived previously, is also formulated in the HJB-based framework. The performance of the proposed algorithms is first tested in a nonlinear control task of swinging a pendulum up with limited torque. It is shown in the simulations that (1) the task is accomplished by the continuous actor-critic method in a number of trials several times fewer than by the conventional discrete actor-critic method; (2) among the continuous policy update methods, the value-gradient-based policy with a known or learned dynamic model performs several times better than the actor-critic method; and (3) a value function update using exponential eligibility traces is more efficient and stable than that based on Euler approximation. The algorithms are then tested in a higher-dimensional task: cart-pole swing-up. This task is accomplished in several hundred trials using the value-gradient-based policy with a learned dynamic model.
Poly(ethylene glycol)-based thiol-ene hydrogels evaluated for their potential as antifouling coatings: Field studies and mechanical properties (2010)

Poly(ethylene glycol)-based thiol-ene hydrogels evaluated for their potential as antifouling coatings: Field studies and mechanical properties
Multiemployer Pension Plan Withdrawal Liability: Limitations without Limits (1992)

Congress enacted the Multiemployer Pension Plan Amendments Act of 1980 ("MPPAA ") to provide greater financial security for pension
Osteomielitis aguda hematógena en menores de un año, República de Mali 2003-2009 (2014)

Objetivo:Evaluar el comportamiento clinico, los microrganismos responsables y el manejo y seguimiento de la osteo-mielitis aguda hematogena en el paciente menor de un ano. Metodo:Se realizo un estudio descriptivo prospectivo de corte longitudinal en 124 lactantes con edades hasta un ano, que acudieron con un sindrome febril agudo al Servicio de Ortopedia de los hospitales Fousseyni Daou de Kayes y Nacional de Kati, entre enero de 2003 y enero de 2009, y a los que se les diagnostico una osteomielitis aguda he-matogena. Resultados: El hallazgo clinico mas frecuente fue la aparicion repentina de dolor de intensidad progresiva en el miem-bro afectado (95,1%), con predileccion por la metafisis de los huesos largos de los miembros inferiores (87,8%). Las infecciones atribuidas a la madre como punto de partida del embolo bacteriano, ocurrieron en el primer trimestre de vida, de ellas, la sepsis puerperal (13,7%) fue la causa etiologica mas frecuente. Staphylococcus aureusfue el germen predominante en estos casos (58,8%). Necesitaron reintervencion quirurgica 59 pacientes (47,5%). Despues de los 18 meses de evolucion el 2,4% de los casos paso a la cronicidad. Conclusiones:La precocidad en el diagnostico de la osteomielitis aguda hematogena y la aplicacion de una terapeu-tica eficaz, en periodos no avanzados de la enfermedad, son los pilares de que depende una evolucion favorable de los pacientes.
Death Prompts a Review of Gene Therapy Vector (2007)

The death last week of a patient receiving experimental gene therapy for arthritis has triggered a federal review of all trials using the same vector. Few details have been made public; if it turns out that the therapy is to blame, it would be another blow to the field's image. Within 8 years, one patient has died as a result of gene therapy and three have acquired leukemia. This would be the first fatality in a trial not studying a life-threatening disease.
Visualizing Statistical Mix Effects and Simpson's Paradox (2014)

We discuss how "mix effects" can surprise users of visualizations and potentially lead them to incorrect conclusions. This statistical issue (also known as "omitted variable bias" or, in extreme cases, as "Simpson's paradox") is widespread and can affect any visualization in which the quantity of interest is an aggregated value such as a weighted sum or average. Our first contribution is to document how mix effects can be a serious issue for visualizations, and we analyze how mix effects can cause problems in a variety of popular visualization techniques, from bar charts to treemaps. Our second contribution is a new technique, the "comet chart," that is meant to ameliorate some of these issues.
From bijels to Pickering emulsions: A lattice Boltzmann study (2011)

Particle stabilized emulsions are ubiquitous in the food and cosmetics industry, but our understanding of the influence of microscopic fluid-particle and particle-particle interactions on the macroscopic rheology is still limited. In this paper we present a simulation algorithm based on a multicomponent lattice Boltzmann model to describe the solvents combined with a molecular dynamics solver for the description of the solved particles. It is shown that the model allows a wide variation of fluid properties and arbitrary contact angles on the particle surfaces. We demonstrate its applicability by studying the transition from a "bicontinuous interfacially jammed emulsion gel" (bijel) to a "Pickering emulsion" in dependence on the contact angle, the particle concentration, and the ratio of the solvents.
Fractal image compression using iterative transforms: applications to DTED (2003)

A review of iterated transformation image compression is presented. Generalization of simple iterated function system fractal generating algorithms to an automated iterated transformation algorithm used to compress gray-scale images is reviewed. Compressed images from the Digital Terrain Elevation Database (DTED) are presented and are compared with encodings using adaptive discrete cosine transformations and mean residual vector quantization image compression techniques.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Semantics-aware malware detection (2005)

A malware detector is a system that attempts to determine whether a program has malicious intent. In order to evade detection, malware writers (hackers) frequently use obfuscation to morph malware. Malware detectors that use a pattern-matching approach (such as commercial virus scanners) are susceptible to obfuscations used by hackers. The fundamental deficiency in the pattern-matching approach to malware detection is that it is purely syntactic and ignores the semantics of instructions. In this paper, we present a malware-detection algorithm that addresses this deficiency by incorporating instruction semantics to detect malicious program traits. Experimental evaluation demonstrates that our malware-detection algorithm can detect variants of malware with a relatively low run-time overhead. Moreover our semantics-aware malware detection algorithm is resilient to common obfuscations used by hackers.
HIF2α–arginase axis is essential for the development of pulmonary hypertension (2016)

Hypoxic pulmonary vasoconstriction is correlated with pulmonary vascular remodeling. The hypoxia-inducible transcription factors (HIFs) HIF-1α and HIF-2α are known to contribute to the process of hypoxic pulmonary vascular remodeling; however, the specific role of pulmonary endothelial HIF expression in this process, and in the physiological process of vasoconstriction in response to hypoxia, remains unclear. Here we show that pulmonary endothelial HIF-2α is a critical regulator of hypoxia-induced pulmonary arterial hypertension. The rise in right ventricular systolic pressure (RVSP) normally observed following chronic hypoxic exposure was absent in mice with pulmonary endothelial HIF-2α deletion. The RVSP of mice lacking HIF-2α in pulmonary endothelium after exposure to hypoxia was not significantly different from normoxic WT mice and much lower than the RVSP values seen in WT littermate controls and mice with pulmonary endothelial deletion of HIF-1α exposed to hypoxia. Endothelial HIF-2α deletion also protected mice from hypoxia remodeling. Pulmonary endothelial deletion of arginase-1, a downstream target of HIF-2α, likewise attenuated many of the pathophysiological symptoms associated with hypoxic pulmonary hypertension. We propose a mechanism whereby chronic hypoxia enhances HIF-2α stability, which causes increased arginase expression and dysregulates normal vascular NO homeostasis. These data offer new insight into the role of pulmonary endothelial HIF-2α in regulating the pulmonary vascular response to hypoxia.
Single event upset in avionics (1993)

Data from military/experimental flights and laboratory testing indicate that typical non-radiation-hardened 64 K and 256 K static random access memories (SRAMs) can experience a significant soft upset rate at aircraft altitudes due to energetic neutrons created by cosmic ray interactions in the atmosphere. It is suggested that error detection and correction circuitry be considered for all avionics designs containing large amounts of semiconductor memory.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Tumour suppressor p53 and Rb genes in human hepatocellular carcinoma. (1996)

Aberrations of the p53 and Rb tumour suppressor genes were examined in 12 human hepatocellular carcinoma (HCC)-derived cell lines from different geographic areas and 9 local HCCs by restriction fragment length polymorphisms (RFLP), polymerase chain reaction-single-strand conformation polymorphisms (PCR-SSCP) and DNA sequencing. The relationships between genetic changes and hepatitis B virus (HBV) DNA integration in samples were compared. None of the cell lines and tumours showed structural changes in the Rb gene, while 6 cell lines and 2 tumours had mutation or deletion in exons 5 to 8 of p53. Mutations include an AGG --> AGT (Arg --> Ser) transversion at codon 249 in PLC/PRF/5 and Mahlavu, an AAT --> AAA (Asn --> Cys) transversion at codon 200 in TONG/HCC, an AAG --> GAG (Lys --> Glu) transition at codon 139 in HCC-T, a CAT --> CGT (His --> Arg) transition at codon 214 in SC4, and a CCC --> CTC (Pro --> Leu) transition at codon 250 in SC8. In Huh4, an 18-bp deletion from codon 264 to 270 resulted in loss of Leu-Gly-Arg-Asn-Ser-Phe from the amino acid sequences 265 to 270, whereas Hep3B had a 7-kb deletion after exon 7 of p53. Our data indicate that whereas Rb may not have pleiotropic effects on HCC, p53 aberrations are frequently involved in hepatocarcinogenesis. Further, HBV infection appears to be unrelated to the micro-genetic changes of p53. The G to T codon-249-mutation is consistent with HCCs arising from areas at high risk for both aflatoxin B1 (AFB1) exposure and HBV infection.
Anti‐rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen‐induced arthritis in rodents (2007)

This study strongly supported HDACi as an innovative therapeutic strategy for RA.
Phase I Study of Alvocidib Followed by 7+3 (Cytarabine + Daunorubicin) in Newly Diagnosed Acute Myeloid Leukemia (2020)

Alvocidib can be safely administered prior to 7+3 induction with encouraging clinical activity. These findings warrant further investigation of alvocidib combinations in newly diagnosed AML. This study was registered at clinicaltrials.gov identifier NCT03298984.
Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets (1974)

Arachidonic acid incubated with human platelets was converted into three compounds, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid, 12L-hydroxy-5,8,10-heptadecatrienoic acid, and the hemiacetal derivative of 8-(1-hydroxy-3-oxopropyl)-9,12L-dihydroxy-5,10-heptadecadienoic acid. The formation of the two latter compounds from arachidonic acid proceeded by pathways involving the enzyme, fatty acid cyclo-oxygenase, in the initial step and with the prostaglandin endoperoxide, PGG(2), as an intermediate. The first mentioned compound was formed from 12L-hydroperoxy-5,8,10,14-eicosatetraenoic acid, which in turn was formed from arachidonic acid by the action of a novel lipoxygenase. Aspirin and indomethacin inhibited the fatty acid cyclo-oxygenase but not the lipoxygenase, whereas 5,8,11,14-eicosatetraynoic acid inhibited both enzymes. The almost exclusive transformation of the endoperoxide structure into non-prostaglandin derivatives supports the hypothesis that the endoperoxides can participate directly and not by way of the classical prostaglandins in regulation of cell functions. The observed transformations of arachidonic acid in platelets also explain the aggregating effect of this acid.
1-Carbamoyl- and 1-aminomethyl-1,4-dihydropyrrolo[3,4-b]indole derivatives. Indole formation by fragmentation of strain-barrier stabilized 2-aminoindoline derivatives (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1-Carbamoyl- and 1-aminomethyl-1,4-dihydropyrrolo[3,4-b]indole derivatives. Indole formation by fragmentation of strain-barrier stabilized 2-aminoindoline derivativesPhilip L. Southwick, Julius A. Vida, Berenice M. Fitzgerald, and Sung Ki LeeCite this: J. Org. Chem. 1968, 33, 5, 2051–2056Publication Date (Print):May 1, 1968Publication History Published online1 May 2002Published inissue 1 May 1968https://pubs.acs.org/doi/10.1021/jo01269a073https://doi.org/10.1021/jo01269a073research-articleACS PublicationsRequest reuse permissionsArticle Views145Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts