gebhart/patrepeval huggingface dataset:
Application of metal–organic frameworks with coordinatively unsaturated metal sites in storage and separation of methane and carbon dioxide (2009)

The metal–organic frameworks M2(dhtp)(H2O)2·8H2O (CPO-27-M, M = Ni, Mg) can be activated to give the empty framework compounds M2(dhtp) with a honeycomb analogous structure containing large micropores of 11–12 Å diameter and a high concentration of open metal sites. These sites play a major role in the adsorption of methane and carbon dioxide, which was studied at pressures up to 100 bar and 50 bar, respectively, and various temperatures in the range of 179 to 473 K. Both gases are taken up by the material in significant amounts. The maximum excess adsorption of CO2 observed at 298 K was 51 wt.% for Ni2(dhtp) and 63 wt.% for Mg2(dhtp). A surprisingly large amount of CO2, in the range 25–30 wt.%, was still adsorbed at 473 K. Up to 18 and 22 wt.% methane were adsorbed at 179 K in the nickel and the magnesium compound, respectively. Congruent with this result is the high isosteric heat of adsorption observed, which was found to be in the range 38–43 kJ mol−1 for CO2 and 20–22 kJ mol−1 for CH4, initially. The heat of adsorption decreases significantly after the open metal sites have been occupied, which also is reflected in the shape of the adsorption isotherms. The vacant coordination site at the metal atom also imparts favorable properties in respect to gas separation onto the material. Breakthrough experiments using Ni2(dhtp) and gas mixtures of CO2–N2 and CO2–CH4 demonstrate the ability of the material to separate these gases. It is shown that carbon dioxide is preferentially adsorbed over methane or nitrogen. In the case of CO2–N2, the retention is quantitative within the precision of the detection system.
High-Performance Transactions for Persistent Memories (2016)

Emerging non-volatile memory (NVRAM) technologies offer the durability of disk with the byte-addressability of DRAM. These devices will allow software to access persistent data structures directly in NVRAM using processor loads and stores, however, ensuring consistency of persistent data across power failures and crashes is difficult. Atomic, durable transactions are a widely used abstraction to enforce such consistency. Implementing transactions on NVRAM requires the ability to constrain the order of NVRAM writes, for example, to ensure that a transaction's log record is complete before it is marked committed. Since NVRAM write latencies are expected to be high, minimizing these ordering constraints is critical for achieving high performance. Recent work has proposed programming interfaces to express NVRAM write ordering constraints to hardware so that NVRAM writes may be coalesced and reordered while preserving necessary constraints. Unfortunately, a straightforward implementation of transactions under these interfaces imposes unnecessary constraints. We show how to remove these dependencies through a variety of techniques, notably, deferring commit until after locks are released. We present a comprehensive analysis contrasting two transaction designs across three NVRAM programming interfaces, demonstrating up to 2.5x speedup.
Striden om den korrekte diagnose og hegemoniet inden for et professionelt område: vetenskabsteoretiske og politiske aspekter (2011)

Abstract in Danish Denne artikel rejser spørgsmålet om grunderne til neuropsykiatriens dominans inden for feltet mentala forstyrrelser. I kapitlets første del søges orsagerne i neuropsykiatriens videnskablige inhold. Diskussionen vil især dreje sig om neuropsykiatrins klassifikations- og førklaringssystem. Det vil bland andet framgå, at neuropsykiatriens fenomenologisk baserede klassifikationer (DSM) er uforenlige med dens fysilogiske forklaringskrav, hvilket betyder, at det næppe er neuropsykiatriens videnskabelige meriter, der er forklaringen på dens dominans. I kapitlets anden del søges årsagerne til denne dominans derfor snarare i ikke-videnskabelige faktorer. Der findes en række ydre omstændigheder, som er særligt gunstige for det neurposykiatriske paradigme. I den forbindelse vil to faktorer blive diskuteret ingående: det almene kulturelle klima og medicinaindustriens optræden. Konklusionen er, at neuropsykiatrien idag udgør et starkt socio-kognitivt regime, et "sandhedsregime", som er bakket op af politiske og økonomiske intresser.
Sequence specific sorting of DNA molecules with FACS using 3dPCR (2017)

Genetic heterogeneity is an important feature of many biological systems, but introduces technical challenges to their characterization. Even with the best modern instruments, only a small fraction of DNA molecules present in a sample can be read, and they are recovered in the form of short, hundred-base reads. In this paper, we introduce 3dPCR, a method to sort DNA molecules with sequence specificity. 3dPCR allows heterogeneous populations of DNA to be sorted to recover long targets for deep sequencing. It is valuable whenever a target sequence is rare in a mixed population, such as for characterizing mutations in heterogeneous cancer cell populations or identifying cells containing a specific genetic sequence or infected with a target virus.
Stochastic inversion transduction grammars and bilingual parsing of parallel corpora (1997)

We introduce (1) a novel stochastic inversion transduction grammar formalism for bilingual language modeling of sentence-pairs, and (2) the concept of bilingual parsing with a variety of parallel corpus analysis applications. Aside from the bilingual orientation, three major features distinguish the formalism from the finite-state transducers more traditionally found in computational linguistics: it skips directly to a context-free rather than finite-state base, it permits a minimal extra degree of ordering flexibility, and its probabilistic formulation admits an efficient maximum-likelihood bilingual parsing algorithm. A convenient normal form is shown to exist. Analysis of the formalism&amp;apos;s expressiveness suggests that it is particularly well suited to modeling ordering shifts between languages, balancing needed flexibility against complexity constraints. We discuss a number of examples of how stochastic inversion transduction grammars bring bilingual constraints to bear upon problematic corpus analysis tasks such as segmentation, bracketing, phrasal alignment, and parsing.
Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation (2010)

In 192 young lone AF patients, we found three patients with suspected disease-causing non-synonymous mutations in SCN3B, indicating that mutations in this gene contribute to the mechanism of lone AF. The three mutations in SCN3B were investigated electrophysiologically and all led to loss of function in the sodium current, supporting the hypothesis that decreased sodium current enhances AF susceptibility.
Alprazolam Kinetics Following Sublingual and Oral Administration (1987)

Thirteen healthy volunteers received 1 mg of alprazolam, as the commercially available oral tablet, by sublingual and oral routes on two occasions in random sequence. Plasma alprazolam concentrations during 48 hours after each dose were measured by electron-capture gas-liquid chromatography. The peak plasma concentration after sublingual dosage was higher than after oral administration (17.3 vs. 14.9 ng/ml), and the time of peak concentration following sublingual administration was reached (1.17 vs. 1.73 hours after dose). However, these differences did not reach statistical significance. The mean total area under the plasma concentration curve for sublingual administration was slightly but not significantly larger than that following oral dosage (203.7 vs. 194.4 hr.ng/ml) and no significant differences between sublingual and oral dosage were found for elimination half-life (11.7 vs. 11.8 hours) or for clearance (86.4 vs. 92.4 ml/min). Thus, alprazolam absorption following sublingual administration is as rapid as after oral dosage on an empty stomach, and completeness of absorption is comparable. In clinical terms, sublingual and oral dosages of alprazolam are likely to be therapeutically equivalent. The sublingual route may be a useful alternative for panic disorder patients who cannot swallow pills or for those who do not have access to a liquid at the time of dosing.
Optical Switching of Ion−Dipole Interactions in a Gramicidin Channel Analogue (2000)

Optical control of ion channel gating could permit the functional manipulation of excitable cells. We wished to examine the feasibility of using optical switching of ion−dipole interactions as a means of switching ion flux in channels. We prepared an analogue of the ion channel gramicidin A in which an azobenzene side chain was substituted for a valine side chain at position 1. The dipole moment of the azobenzene group can be reversibly switched between approximately 3 and 0 D by cis−trans photoisomerization. The observed conductance properties of the modified channels can be understood in terms of (switchable) ion−dipole interactions that control the height of the central barrier for Cs+ and Na+ movement through the pore. The predictable behavior of the system implies that larger dipole changes or changes closer to the central axis of the pore might effect complete gating.
Hormonal Regulation of Free Intracellular Calcium Concentrations in Small and Large Ovine Luteal Cells1 (1989)

The second messengers mediating hormonal regulation of the corpus luteum are incompletely defined, particularly for the primary luteolytic hormone prostaglandin F2 alpha (PGF2 alpha). In this study, hormonally induced changes in free intracellular calcium concentrations were measured in individual small and large ovine luteal cells by using computer-assisted microscopic imaging of fura-2 fluorescence. This technique could readily detect transient increases in free calcium concentrations within both small and large luteal cells after treatment with 1 microM of the calcium ionophore, A23187. Treatment with PGF2 alpha (1 microM) caused a dramatic increase in free calcium concentrations in large (before = 73 +/- 2 nM; 2 min after PGF2 alpha = 370 +/- 21 nM; n = 33 cells) but not in small (before = 66 +/- 4 nM; 2 min after PGF2 alpha = 69 +/- 8 nM; n = 12 cells) luteal cells. The magnitude and timing of the calcium response was dose- and time-dependent. The PGF2 alpha-induced increase in free intracellular calcium is probably due to influx of extracellular calcium, since inclusion of inorganic calcium channel blockers (100 microM manganese or cobalt) attenuated the response to PGF2 alpha and removal of extracellular calcium eliminated the response. In contrast to PGF2 alpha, luteinizing hormone (LH) (100 ng/ml) caused no change in intracellular levels of free calcium in small or large luteal cells, even though this dose of LH stimulated (p less than 0.01) progesterone production by small luteal cells. Therefore, alterations in free calcium concentrations could be the intracellular second message mediating the luteolytic action of PGF2 alpha in the large ovine luteal cell.
Palladium-Catalyzed Cross-Coupling Reaction of Cyclopropylboronic Acids with Aryl Triflates (2000)

In the presence of appropriate base and NaBr, the Suzuki-type reaction of aryl triflates and trans-cyclopropylboronic acids proceed readily to give pure trans-cyclopropylarenes in good to high yields. For the reaction of general aryl triflates, the base KF · 2 H2O is efficient, but in the case of aryl triflates bearing electron donating groups, KF · 2 H2O as a base makes the unexpected phenyl-aryl exchange between the phenyl of Pd(PPh3)4 and the aryl of triflate to occur. The use of K3PO4 · 3 H2O instead of KF · 2 H2O can inhibit the unexpected phenyl-aryl exchange, but the yield of the product is somewhat decreased. The coupling reaction of aryl triflates with the optically active cyclopropylboronic acids, which were easily obtained in good yield and with good to excellent ee (up to 94%) by the asymmetric cyclopropanation of alkenylboronates with optically pure TMTA auxiliary, was also investigated. During the coupling reaction, the absolute configuration of the cyclopropyl group was retained. Thus, a novel method to prepare aryl-substituted cyclopropanes, including highly optically active cyclopropanes, from phenols or arylamines was provided.
Nestin Expression by Newly Formed Human Blood Vessels (2004)

Nestin is a type VI intermediate filament protein originally described in neural stem cells. Here we report that immature endothelial cells generated in the course of angiogenesis express nestin. Endothelial cells of embryonic capillaries destined to vascularize growing organs also express this intermediate filament protein. Whereas nestin was sporadically expressed in mature adult human endothelial cells sporadically express nestin, this protein was consistently expressed in adult angiogenic vasculature. Nestin expression was also detected in capillaries of the corpus luteum, which replenishes itself by angiogenesis. Nestin-immunoreactive vessels were also observed in the infarcted hearts where transient ischemia triggered regeneration accompanied with neovascularization of the myocardium. Nestinpositive endothelial cells lined vessels nourishing solid growing tumors, including melanoblastomas and glioblastomas. Our data provide definitive evidence that endothelial precursors express the neural stem cell marker nestin and that this protein participates in formation of the cytoskeleton of newly formed endothelial cells. Because nestin expression was recognized under all conditions of vascular development, nestin represents a novel and reliable marker of neovascularization.
Application of bioinformatics-coupled experimental analysis reveals a new transport-competent nuclear localization signal in the nucleoprotein of Influenza A virus strain (2008)

This report while not only establishing a new NLS in the influenza A virus strain, it also reinforces the idea that proper application of bioinformatics-coupled experimental analysis serves as a powerful tool in identifying new functional signals in proteins of interest.
Moving from rhetoric to reality: adapting Housing First for homeless individuals with mental illness from ethno-racial groups (2012)

Adapting Housing First with anti-racism/anti-oppression principles offers a promising approach to serving the diverse needs of homeless people from ethno-racial groups and strengthening the service systems developed to support them. The use of fidelity and implementation evaluations can be helpful in supporting successful adaptations of programs and services.
Synthesis, Single-Crystal X-ray Microdiffraction, and NMR Characterizations of the Giant Pore Metal-Organic Framework Aluminum Trimesate MIL-100 (2009)

This contribution deals with the hydrothermal synthesis of the metal-organic framework aluminum trimesate, analogous to the MIL-100-type, previously reported with chromium(III) and iron(III). MIL-100(Al) crystallizes within a very narrow pH range (0.5−0.7) after heating a mixture of aluminum nitrate, trimethyl 1,3,5-benzenetricarboxylate (Me3btc), nitric acid, and water at 210 °C for 3.5 h. The resulting product consists of tiny octahedral shaped crystals of 2 μm size, which have been used for the atomic structure determination. It was carried out by means of single crystal using the microdiffraction setup together with microfocalized synchrotron radiation at station ID13 (ESRF, France). Solid-state NMR characterization was fully consistent with XRD structure but with higher local symmetry. The three-dimensional open framework obtained from direct methods calculations reveals the arrangement of supertetrahedral (ST) building blocks based on the MTN topology (related to the zeolite ZSM-39). Each ST motif is built up from four μ3-oxo-centered trinuclear unit (Al3O) located at each corner and linked to the four btc ligands located on each face of the tetrahedron. MIL-100 (Al) exhibits BET and Langmuir surface area of 2152(39) m2 g−1 and 2919(44) m2 g−1, respectively (pore volume: 0.82 cm3 g−1).
Efficient adenoviral infection with IκBα reveals that macrophage tumor necrosis factor α production in rheumatoid arthritis is NF-κB dependent (1998)

Tumor necrosis factor (TNF) alpha has been shown to be a major therapeutic target in rheumatoid arthritis with the success of anti-TNFalpha antibody clinical trials. Although signaling pathways leading to TNFalpha expression have been studied in some detail, there is evidence for considerable differences between individual cell types. This prompted us to investigate the intracellular signaling pathways that result in increased TNFalpha synthesis from macrophages in the diseased synovial joint tissue. Using an adenoviral system in vitro we report the successful delivery of genes to more than 95% of normal human macrophages. This permitted us to show, by using adenoviral transfer of IkappaB alpha, the natural inhibitor of NF-kappaB, that induction of TNFalpha in normal human macrophages by lipopolysaccharide, but not by some other stimuli, was inhibited by 80%. Furthermore the spontaneous production of TNFalpha from human rheumatoid joint cell cultures was inhibited by 75%, indicating that the NF-kappaB pathway is an essential step for TNFalpha synthesis in synovial macrophages and demonstrating that NF-kappaB should be an effective therapeutic target in this disease.
Design and implementation of an RSVP-based quality of service architecture for integrated services Internet (2002)

The paper presents the design and implementation of a quality of service architecture for the Internet. The architecture is based on the emerging standards for resource reservation in the Internet, namely the RSVP protocol and the associated service specifications defined by the Internet Engineering Task Force. Our architecture represents a major functional enhancement to the traditional sockets based communication subsystem, while preserving application programming interface and binary compatibility with existing applications. It is scalable and supports a variety of network interfaces ranging from legacy LAN interfaces, such as token ring and Ethernet, to high speed ATM interfaces. We also describe our initial experiences with the implementation of this architecture on the IBM AIX platform.
Zr(iv) and Hf(iv) based metal–organic frameworks with reo-topology (2012)

Zr and Hf based MOFs with enhanced pore accessibility for large molecules and good hydrothermal stability were obtained using a bent dithienothiophene dicarboxylate and Zr(4+) or Hf(4+) source. A modulator (benzoic acid) facilitates formation of an eight-connecting cluster leading to a new framework which adopts reo topology.
Efficient Screening and Library Generation in Parallel C–C Coupling Reactions Mediated by Organosilica SiliaCat Palladium Catalysts (2011)

Organosilica SiliaCat palladium catalysts applied to the conversion of widely different substrates in Suzuki, Sonogashira, and Heck coupling reactions run in a parallel synthesizer enable quick screening of the reaction system with identification of the best reaction conditions and rapid library generation.
Transferrin-Conjugated Liposome Targeting of Photosensitizer AlPcS4 to Rat Bladder Carcinoma Cells (2004)

Transferrin-mediated liposomal targeting of photosensitizing drugs is a promising potential tool for photodynamic therapy of superficial bladder tumors.
IMS Crash Course (2006)

An Introduction to This Innovative and Revolutionary Next-Generation Communication Solution

The IP Multimedia Subsystem (IMS) is a powerful, emerging technology that will change the way we live, work, and communicate. Through convergence of fixed and wireless networks, IMS delivers seamless roaming to multimedia devices regardless of location or access modality. This much-needed resource gives you an easy-to-understand overview of the development, evolving standards, and excitingly imminent future of IMS.

Expand Your Understanding of IMS

Written by a renowned professional author and educator with 25 years of experience in the telecommunications industry, IMS Crash Course gives you a broad perspective on why IMS evolved, how the technology works, its system requirements, and potential regulatory issues—all in one convenient package. If you are looking to make sense of this breakthrough technology, its benefits, and its real-world implementations, read this book first.

Full coverage of IMS including:

An early history of IMS Converging wireless and wireline Network, software, and signaling requirements IMS regulatory issues IMS’s future
Interference with ATF5 function enhances the sensitivity of human pancreatic cancer cells to paclitaxel-induced apoptosis. (2012)

ATF5 is highly expressed in pancreatic cancer cells. Targeting ATF5 significantly enhances paclitaxel-induced apoptosis in human pancreatic cancer cells. ATF5 could be an important therapeutic target for pancreatic cancer treatment.
Establishment of a temperature-dependent cell line from rat endometrium by retroviral infection. (1991)

We have established a cell line, RENTts3.1, by infection of primary rat endometrial cells with a retrovirus carrying a temperature-sensitive mutant of SV40 large T-antigen. These cells show a temperature-dependent phenotype with respect to morphology, growth and expression of macrophage colony-stimulating factor 1 (CSF-1) mRNA. At the permissive temperature, the cells grow with a doubling time of 24 h and exhibit an elongated, fibroblast-like morphology. They express vimentin and type III collagen mRNA. At the non-permissive temperature, the cells stop growing and exhibit an epitheloid morphology with flat enlarged cytoplasm. At the higher temperature, the cells continue to express type III collagen, but also express CSF-1 mRNA, and the cellular content of this transcript is influenced by glucocorticoid treatment. No expression of the epithelial markers cytokeratin, uteroglobin, beta-endorphin or preproenkephalin was detected, suggesting a stromal origin of the cell line. Electron microscopic data of cells cultivated on different substrates also support this conclusion. This cell line may be useful for the study of the molecular processes involved in decidual transformation of the endometrial mucosa.
스포츠생리학 / 규칙적인 수영운동이 여성들의 운동빈도별 순환 능력 , 체력 및 혈청 지질수준에 미치는 효과 (2000)

30-40대 수영참가 여성들의 운동빈도별 순환능력, 체력 및 혈청 지질의 변화를 살펴보기 위하여 초보 수영교실반 여성을 대상으로 12주간의 수영 운동빈도(주 3회군 7명, 주 6회군 10명, 통제군 10명)에 따라 처치기간별 각 변인등을 측정 분석한 결과 운동 빈도별 3회 및 6회군의 처치기간별 심박수와 수축기 혈압은 운동전에는 유의한 변화가 없었으나,12주 운동후 유의하게(p<0.0001, p<0.0204) 높은 감소를 나타냈으며, 12주 운동후 각 그룹간 주 6회군의 감소, 3회군의 증가 순으로 유의한(p<0.024, p<0.0376) 변화를 나타냈다. 그러나 통제군의 경우 각 기간별 일부 경미한 변화는 있었지만 유의한 차는 없었다. 최대 산소섭취량의 변화는 각 기간별 유의하게(p<0.0001) 높은 증가를 나타냈으며, 그룹간의 차에서는 주 6회군, 3회군 순으로 유의한 증가를 나타냈다(p<0.0001). 통제군의 경우 유의한 차는 없었다. 처치기간별 체력의 변화는 배근력, 순발력 및 평행성에서 유의하게(p<0.0001) 높은 증가를 나타냈으며, 각 그룹간 유의한 차이는 없었다. 3회 및 6회군의 처치기간별 혈청지질의 변화의 경우 운동전반에 걸쳐 총 콜레스테롤 및 중성지방의 감소와 고밀도 지단백 콜레스테롤의 증가 및 총 콜레스테롤에 대한 고밀도 지단백질 분획치의 감소에 따라 유의한 (p＜0.0001, p＜0.0001, p＜0.0001, p<0.0031) 차이를 나타냈다. 통제군은 일부 증감의 현산은 있었지만 유의한 차는 없었다. 그룹간의 총 콜레스테롤, 중성지방 및 총 콜레스테롤/고밀도 지단백질 분획치의 경우도 유의한(p<0.0319) 차를 나타냈다. 이상의 결과로 볼 때 운동 빈도별 규칙적인 수영운동은 전반적인 순환능력 및 체력의 일부요인에 영향을 미치는 것으로 생각할 수 있으며, 특히 지질의 경우 운동빈도가 적은 주 3회군에서 변화정도에서 운동량이 많은 주 6회군보다 긍정적인 효과를 가져온 것으로 보아 추후 수영운동의 빈도 및 강도의 선택폭을 넓혀 적용해야할 것으로 사료된다.