gebhart/patrepeval huggingface dataset:
Influence of mirror reflectivity on laser performance of very-low-threshold vertical-cavity surface-emitting lasers (1995)

The influeuce of mirror reflectivity on laser performance of InGaAs-GaAs vertical-cavity surface-emitting lasers fabricated by selective oxidation is investigated by the stepwise change of the number of pairs in top mirror stack after device fabrication. Devices with 18-pair stacks in the top mirror, which is the optimized number of pairs in this structure, show an output power over 1.9 mW and a slope efficiency of 55% while maintaining a low threshold current of 212 μA. The analysis of the threshold current and differential efficiency related to mirror reflectivity shows an internal quantum efficiency of 95%, an internal round-trip loss of 0.072, and a transparency current density of 71 A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Phonetic string matching (1996)

Article Free Access Share on Phonetic string matching: lessons from information retrieval Authors: Justin Zobel Department of Computer Science, RMIT, GPO Box 2476V, Melbourne, Australia 3001 Department of Computer Science, RMIT, GPO Box 2476V, Melbourne, Australia 3001View Profile , Philip Dart Department of Computer Science, The University of Melbourne, Parkville, Melbourne, Australia 3052 Department of Computer Science, The University of Melbourne, Parkville, Melbourne, Australia 3052View Profile Authors Info & Claims SIGIR '96: Proceedings of the 19th annual international ACM SIGIR conference on Research and development in information retrievalAugust 1996 Pages 166–172https://doi.org/10.1145/243199.243258Published:18 August 1996Publication History 109citation1,533DownloadsMetricsTotal Citations109Total Downloads1,533Last 12 Months185Last 6 weeks22 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Circular dichroism of some optically active 2,3-dichloromaleimides. (2001)

Optically active derivatives of 2,3-dichloromaleimide give bisignate exciton-coupled type Cotton effects in circular dichroism spectra which can be correlated with the absolute configuration of chiral non-racemic aryl amines, aryl alpha-amino acids, and amino alcohols. The presented data indicate that these experimentally observed Cotton effects originate from the pi-->pi* electronic transition of the maleimide chromophore and that this transition is polarized perpendicularly to the symmetry axis of the maleimide chromophore.
A Survey on Homomorphic Encryption Schemes: Theory and Implementation (2017)

Legacy encryption systems depend on sharing a key (public or private) among the peers involved in exchanging an encrypted message. However, this approach poses privacy concerns. Especially with popular cloud services, the control over the privacy of the sensitive data is lost. Even when the keys are not shared, the encrypted material is shared with a third party that does not necessarily need to access the content. Moreover, untrusted servers, providers, and cloud operators can keep identifying elements of users long after users end the relationship with the services. Indeed, Homomorphic Encryption (HE), a special kind of encryption scheme, can address these concerns as it allows any third party to operate on the encrypted data without decrypting it in advance. Although this extremely useful feature of the HE scheme has been known for over 30 years, the first plausible and achievable Fully Homomorphic Encryption (FHE) scheme, which allows any computable function to perform on the encrypted data, was introduced by Craig Gentry in 2009. Even though this was a major achievement, different implementations so far demonstrated that FHE still needs to be improved significantly to be practical on every platform. First, we present the basics of HE and the details of the well-known Partially Homomorphic Encryption (PHE) and Somewhat Homomorphic Encryption (SWHE), which are important pillars of achieving FHE. Then, the main FHE families, which have become the base for the other follow-up FHE schemes are presented. Furthermore, the implementations and recent improvements in Gentry-type FHE schemes are also surveyed. Finally, further research directions are discussed. This survey is intended to give a clear knowledge and foundation to researchers and practitioners interested in knowing, applying, as well as extending the state of the art HE, PHE, SWHE, and FHE systems.
Bit synchronization and timing sensitivity in adaptive Viterbi equalizers for narrowband-TDMA digital mobile radio systems (2003)

An adaptive Viterbi-MLSE equalizer for narrowband-TDMA (time-division multiple-access) digital mobile radio systems is presented which uses a straightforward channel sounding technique for fast periodic equalizer start-up. The equalizer is specifically tailored for the application with h=0.5 partial-response CPM (continuous-phase modulation) schemes such as GMSK or GTFM. Exploiting the features of the channel-sounding Viterbi equalizer, a simple sample timing and bit synchronization technique is developed which uses a free-running sampling clock. The timing sensitivity of a digital mobile radio receiver based on the presented equalization and synchronization concepts is studied by computer simulations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Biostimulant Seed Coating Treatments to Improve Cover Crop Germination and Seedling Growth (2020)

Biostimulant seed coating formulations were investigated in laboratory experiments for their potential to increase maximum germination, germination rate, germination uniformity, and seedling growth of red clover (Trifolium pratense L.) and perennial ryegrass (Lolium perenne L.) seeds. Red clover and perennial ryegrass seeds were coated with different combinations of soy flour, diatomaceous earth, micronized vermicompost, and concentrated vermicompost extract. Coated and non-coated seeds of red clover and perennial ryegrass were evaluated for germination and growth after 7 and 10 days, respectively. Red clover seed was maintained at a constant 20 °C with a 16/8 h photoperiod, whereas for perennial ryegrass seed, the germinator was maintained at 15/25 °C, with the same photoperiod as red clover. Coated treatments significantly improved germination rate and uniformity with no reduction in total germination, compared to the non-treated controls in red clover. In contrast, for perennial ryegrass, the total germination percentage of all coated seeds was reduced and displayed a delayed germination rate, compared with the non-treated controls. Shoot length, seedling vigor index, and dry weight of seedlings of coated seed treatments of both crops were significantly higher when compared to controls for both species. In addition to growth metrics, specific surface mechanical properties related to seed coating quality of seeds of both species were evaluated. Increasing the proportion of soy flour as a seed treatment binder in the coating blend increased the integrity and compressive strength of coated seeds, and the time for coatings to disintegrate. These data show that seed coating technologies incorporating nutritional materials and biostimulants can enhance seedling growth and have the potential to facilitate the establishment of cover crops in agriculture and land reclamation.
Millimetre-wave propagation through hydrocarbon flame (1987)

The propagation of microwave and millimetre-wave signals through flame has been investigated with reference to the reliability of future communications systems on deep-water oil production platforms. The results show that the 0.5 m thick flame investigated produced little attenuation,&gt;0.5 dB at frequencies between 37 and 210 GHz, but that scintillation effects were enhanced by the presence of flame, particularly at the higher frequencies, with ~4 dB peak-to-peak fluctuations at 210 GHz.
A protocol and server for a distributed digital technical report library (1994)

This paper describes {\bf Dienst} -- a Distributed Interactive Extensible Network Server for Techreports. The Dienst protocol is based on the World Wide Web protocol HTTP, and provides an object-oriented interface to a document model. The document model allows one to access the document as a whole or by named sub-parts and it supports multiple formats for the document. We have also implemented a gateway from a Web server that supports the Dienst protocol. Using a World Wide Web client (e.g. Mosaic), a user may search for documents at distributed sites, browse "thumbnail" (very small page) images, view the full documents, and print them.
Differential Responses of Human Regulatory T Cells (Treg) and Effector T Cells to Rapamycin (2009)

RAPA favors Treg expansion and survival by differentially regulating signaling, proliferation and sensitivity to apoptosis of human effector T cells and Treg after TCR/IL-2 activation.
Single‐Chain Antibodies in Pancreatic Cancer (1999)

Pancreatic cancer is a therapeutic challenge for surgical and medical oncology. Development of specific molecular tracers for the diagnosis and treatment of this lethal cancer has been one of our major goals. Monoclonal antibodies (MAbs) have been successfully used as selective carriers for delivering radionuclides, toxins or cytotoxic drugs to malignant cell populations; therefore, monoclonal antibody technology has led to a significant amount of research into optimizing targeted therapy. This targeted therapy results in the selective concentration of cytotoxic agents or radionuclides in tumors and should lessen the toxicity to normal tissues, which would normally limit the dosage and effectiveness of systemically administered drugs. The MAb CC49 reacts with a unique disaccharide, Sialyl-Tn, present on tumor-associated mucin (TAG-72) expressed by a majority of human adenocarcinomas. The unique Sialyl-Tn epitope has provided a potential target for immunotherapy of cancer. A single chain Fv (scFv) recombinant protein from CC49 MAb was prepared by engineering the DNA fragments for coding heavy-chain and light-chain variable regions with an appropriate oligonucleotide linker. scFv molecules, when compared to intact MAbs and the more conventional enzymatically derived F(ab')2 and Fab' fragments, offer several advantages as carriers for the selective delivery of radionuclides to tumors. The divalent antibody fragments (sc(Fv)2 or (scFv)2) display an affinity constant similar to that of the intact CC49 IgG and are stable with storage, and after radiolabeling. In preclinical studies, both the covalent and the non-covalent dimeric scFvs exhibit excellent tumor targeting properties with characteristics similar to those of the monomer, e.g., the rapid blood clearance, low kidney uptake and small size suitable for rapid penetration through tumor tissue. Increased tumor targeting of the dimers are probably due to their increased functional affinity attributable to valency, coupled with their higher molecular weight and fewer interactions with normal organs. These properties make these constructs superior to monovalent CC49 scFv. The relatively high tumor uptake, the in vitro and in vivo targeting specificity, and the stability in storage demonstrated by the dimeric CC49 sc(Fv)2 makes it a promising delivery vehicle for therapeutic applications in pancreatic cancer.
The involvement of lipid rafts in the regulation of integrin function (2002)

Integrin activity on cells such as T lymphocytes is tightly controlled. Here we demonstrate a key role for lipid rafts in regulating integrin function. Without stimulation integrin LFA-1 is excluded from lipid rafts, but following activation LFA-1 is mobilised to the lipid raft compartment. An LFA-1 construct from which the I domain has been deleted mimics activated integrin and is constitutively found in lipid rafts. This correlation between integrin activation and raft localisation extends to a second integrin, alpha4beta1, and the clustering of alpha4beta1 is also raft dependent. Both LFA-1 and alpha4beta1-mediated adhesion is dependent upon intact lipid rafts providing proof of the functional relevance of the lipid raft localisation. Finally we find that non-raft integrins are excluded from the rafts by cytoskeletal constraints. The presence of integrin in lipid rafts under stimulating conditions that activate these receptors strongly indicates that the rafts have a key role in positively regulating integrin activity.
NRZ operation at 40 Gb/s of a compact module containing an MQW electroabsorption modulator integrated with a DFB laser (1997)

NRZ operation at 40 Gb/s has been successfully performed using a very compact module of a multiple-quantum-well (MQW) electroabsorption modulator integrated with a distributed-feedback (DFB) laser. While the DFB laser is injected with a constant current, the integrated MQW electroabsorption modulator is driven with a 10-Gb/s electrical NRZ signal. A clearly opened eye diagram has been observed in the modulated light from the modulator. And a receiver sensitivity of -27.2 dBm at 10/sup -9/ has been experimentally confirmed in the bit-error-rate (BER) performance.
Cardiovascular Morbidity in Obstructive Sleep Apnea (2007)

Sleep-disordered breathing and obstructive sleep apnea (OSA) are highly prevalent disorders throughout the lifespan, which may affect up to 2-10% of the population, and have now been firmly associated with an increased risk for cardiovascular and neurobehavioral complications. Nevertheless, the overall pathophysiologic mechanisms mediating end-organ injury in OSA remain undefined, particularly due to the very frequent coexistence of other disease states, such as obesity, that clearly complicate the potential cause-effect relationships. Two major, and to some extent overlapping, mechanisms have been proposed to explain the morbid consequences of OSA, namely increased generation and propagation of reactive oxygen species and initiation and amplification of inflammatory processes. The evidence supporting the validity of these concepts as well as that detracting from such mechanisms will be critically reviewed in the context of clinical and laboratory-based approaches. In addition, some of the contradictory issues raised by such evaluation of the literature will be interpreted in the context of putative modifications of the individual responses to OSA, as determined by genetic variants among susceptibility-related genes, and also by potential environmental modulators of the phenotypic expression of any particular end-organ morbidity associated with OSA.
Cloning and characterization of the promoter for the liver isoform of the rat carnitine palmitoyltransferase I (L-CPT I) gene (1998)

Carnitine palmitoyltransferase I (CPTI) catalyses the transfer of long chain fatty acids to carnitine for translocation across the mitochondrial inner membrane. The cDNAs of two isoforms of CPT I, termed the hepatic and muscle isoforms, have been cloned. Expression of the hepatic CPT I gene (L-CPT I) is subject to developmental, hormonal and tissue specific regulation. We have cloned the promoter of the L-CPTI gene from a rat genomic library. In the L-CPTI gene, there are two exons 5' to the exon containing the ATG that initiates translation. Exon 1 and the 5' end of exon 2 contain sequences that were not previously described in the rat L-CPTI cDNA. There is an alternatively spliced form of the L-CPTI mRNA in which exon 2 is skipped. The proximal promoter of the L-CPTI gene is extremely GC rich and does not contain a TATA box. There are several putative Sp1 binding sites near the transcriptional start site. A 190 base pair fragment of the promoter can efficiently drive transcription of luciferase and CAT (chloramphenicol acetyltransferase) reporter genes transiently transfected into HepG2 cells. Sequences in both the first intron and the promoter contribute to basal expression. Our results provide the foundation for further studies into the regulation of L-CPTI gene expression.
Noninvasive Surface Measurement of Corrosion Impedance of Reinforcing Bar in Concrete— Part 3: Effect of Geometry and Material Properties (2004)

The authors’ laboratory experiments have shown that valuable information on the corrosion of reinforced concrete can be obtained by placing four electrodes parallel to the reinforcing bar on the concrete surface and measuring impedance. Mathematical modeling has confirmed that any change in the interfacial impedance at the reinforcing bar/concrete interface can be captured from the measured impedance on the concrete surface. For the four-electrode configuration, both the electrical capacitance and resistance of the measured impedance become geometry dependent and it depends on the interfacial impedance, the measurement geometry, and the concrete material property. To illustrate this dependence, the paper presents both experimental results and numerical simulations to show how the geometry and the concrete property affect the surface-measured impedance for a constant interfacial impedance. The considered variables include the relative direction between the electrode array and the reinforcing bar, the ratio of the electrode distance to the concrete cover, and the concrete resistivity. The model in another study by three of the authors has been used to simulate the impedance responses from the constant interfacial impedance as a function of the aforementioned variables. The study of the geometric effect can help to interpret measured data and optimize the measurement setup, and it can also derive the embedded reinforcing bar’s position and the depth of concrete cover.
Molecular Cloning of a New Interferon-induced Factor That Represses Human Immunodeficiency Virus Type 1 Long Terminal Repeat Expression (1995)

Transcriptional induction of genes is an essential part of the cellular response to interferons. To isolate yet unidentified IFN-regulated genes we have performed a differential screening on a cDNA library prepared from human lymphoblastoid Daudi cells treated for 16 h with human alpha/beta interferon (Hu-alpha/beta IFN). In the course of these studies we have isolated a human cDNA which codes for a protein sharing homology with the mouse Rpt-1 gene; it will be referred as Staf-50 for Stimulated Trans-Acting Factor of 50 kDa. Amino acid sequence analysis revealed that Staf-50 is a member of the Ring finger family and contains all the features of a transcriptional regulator able to initiate a second cascade of gene induction (secondary response). Staf-50 is induced by both type I and type II IFN in various cell lines and down-regulates the transcription directed by the long terminal repeat promoter region of human immunodeficiency virus type 1 in transfected cells. These data are consistent with a role of Staf-50 in the mechanism of transduction of the IFN antiviral action.
Strategies for Covalent Attachment of Doxorubicin to Poly(PEG-Lys), a New Water-Soluble Poly(ether urethane (1994)

Poly(PEG-Lys) is a new, water soluble poly(ether urethane) that has shown promise as an injectable drug carrier. To evaluate the possible use of this drug carrier in chemotherapy, three different approaches for the covalent attachment of doxorubicin to the pendent carboxylic acid groups of poly(PEG- Lys) were developed. In one approach, the pendent carboxylic acid groups of poly(PEG-Lys) were converted to N-hydroxysuccinimide active esters, which spontaneously formed hydrolytically stable amide bonds upon reaction with the amino group located on the daunosamine ring of doxorubicin. The amount of amide-bound doxorubicin was about 7.3 mg/100 mg of conjugate. In a second approach, the degradable hydrazone linkage was formed by reaction of the polymeric hydrazide derivative of poly(PEG-Lys), designated as poly(PEG-Lys hydrazide), with the 13-keto group of doxorubicin. After purification, the amount of carrier-bound doxorubicin was 13.5 mg/100 mg of conjugate. In the third approach, the conjugation of doxorubicin via secondary amine linkages was explored. In this approach, the aldehyde derivative of poly(PEG Lys), desig nated as poly(PEG-Lys-aldehyde), was reacted with doxorubicin, followed by re duction of the intermediate Schiff base with sodium cyanoborohydride. After extensive purification of the carrier, the amount of bound doxorubicin was 10 mg/100 mg of conjugate. All conjugates were characterized by UV/Vis and FTIR spectroscopy and by thin layer chromatography. The conjugates were free of de tectable contamination by unbound drug.
Eukaryotic Translation Initiation Factor 4E (eIF4E) Binding Site and the Middle One-Third of eIF4GI Constitute the Core Domain for Cap-Dependent Translation, and the C-Terminal One-Third Functions as a Modulatory Region (2000)

The mammalian eukaryotic initiation factor 4GI (eIF4GI) may be divided into three roughly equal regions; an amino-terminal one-third (amino acids [aa] 1 to 634), which contains the poly(A) binding protein (PABP) and eIF4E binding sites; a middle third (aa 635 to 1039), which binds eIF4A and eIF3; and a carboxy-terminal third (aa 1040 to 1560), which harbors a second eIF4A binding site and a docking sequence for the Ser/Thr kinase Mnk1. Previous reports demonstrated that the middle one-third of eIF4GI is sufficient for cap-independent translation. To delineate the eIF4GI core sequence required for cap-dependent translation, various truncated versions of eIF4GI were examined in an in vitro ribosome binding assay with beta-globin mRNA. A sequence of 540 aa encompassing aa 550 to 1090, which contains the eIF4E binding site and the middle region of eIF4GI, is the minimal sequence required for cap-dependent translation. In agreement with this, a point mutation in eIF4GI which abolished eIF4A binding in the middle region completely inhibited ribosomal binding. However, the eIF4GI C-terminal third region, which does not have a counterpart in yeast, modulates the activity of the core sequence. When the eIF4A binding site in the C-terminal region of eIF4GI was mutated, ribosome binding was decreased three- to fourfold. These data indicate that the interaction of eIF4A with the middle region of eIF4GI is necessary for translation, whereas the interaction of eIF4A with the C-terminal region plays a modulatory role.
A DNA Sequence Recognition Loop on APOBEC3A Controls Substrate Specificity (2014)

APOBEC3A (A3A), one of the seven-member APOBEC3 family of cytidine deaminases, lacks strong antiviral activity against lentiviruses but is a potent inhibitor of adeno-associated virus and endogenous retroelements. In this report, we characterize the biochemical properties of mammalian cell-produced and catalytically active E. coli-produced A3A. The enzyme binds to single-stranded DNA with a Kd of 150 nM and forms dimeric and monomeric fractions. A3A, unlike APOBEC3G (A3G), deaminates DNA substrates nonprocessively. Using a panel of oligonucleotides that contained all possible trinucleotide contexts, we identified the preferred target sequence as TC (A/G). Based on a three-dimensional model of A3A, we identified a putative binding groove that contains residues with the potential to bind substrate DNA and to influence target sequence specificity. Taking advantage of the sequence similarity to the catalytic domain of A3G, we generated A3A/A3G chimeric proteins and analyzed their target site preference. We identified a recognition loop that altered A3A sequence specificity, broadening its target sequence preference. Mutation of amino acids in the predicted DNA binding groove prevented substrate binding, confirming the role of this groove in substrate binding. These findings shed light on how APOBEC3 proteins bind their substrate and determine which sites to deaminate.