gebhart/patrepeval huggingface dataset:
Approximations for Digital Computers (1955)

Numerical analysts and computer operators in all fields will welcome this publication in book form of Cecil Hastings' well-known approximations for digital computers, formerly issued in loose sheets and available only to a limited number of specialists. In a new method that combines judgment and intuition with mathematics, Mr. Hasting has evolved a set of approximations which far surpasses in simplicity earlier approximations developed by conventional methods. Part I of this book introduces the collection of useful and illustrative approximations, each of which is presented with a carefully drawn error curve in Part II. Originally published in 1955. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
A Skew Remedy Algorithm based on Searching the Main Direction (2005)

The paper presents an algorithm for skew remedy based on searching the main direction to acquire the parameters of the skew image. The algorithm computes the horizontal and vertical difference of the distorted image, and find the main direction which make the discriminate function to achieve maximum. Finally some smoothing procedures are used to erase the burrs of characters in the remedied image. The algorithm thoroughly utilizes the features of skew image and uses the optimal search strategy.
A Randomized Trial Comparing the Efficacy and Safety of Intravitreal Triamcinolone With Standard Care to Treat Vision Loss Associated With Macular Edema Secondary to Branch Retinal Vein Occlusion (2009)

Objective: To compare the efficacy and safety of 1-mg and 4-mg doses of preservative-free intravitreal triamcinolone with standard care (grid photocoagulation in eyes without dense macular hemorrhage and deferral of photocoagulation until hemorrhage clears in eyes with dense macular hemorrhage) for eyes with vision loss associated with macular edema secondary to branch retinal vein occlusion (BRVO).
Spectroscopy of alkali atoms and molecules in superfluid helium (1993)

We report on the first laser spectroscopy of alkali atoms (Cs and Rb) and molecules (${\mathrm{Na}}_{2}$ and ${\mathrm{Li}}_{2}$) in superfluid helium. General features of the observed spectra can be explained in terms of the spherical atomic bubble model. The excitation and emission spectra for the ${\mathit{D}}_{2}$- lines, however, have double peaked profiles, indicating the importance of the nonspherical density distribution of surrounding helium atoms. The emission spectra for the molecules show well-resolved vibrational structures in the electronic ground states.
Identification of Novel Biomarkers for Sepsis Prognosis via Urinary Proteomic Analysis Using iTRAQ Labeling and 2D-LC-MS/MS (2013)

ClinicalTrial.gov NCT01493492.
PCR based diagnosis in the presence of 8% (v/v) blood (1991)

Journal Article PCR based diagnosis in the presence of 8% (v/v) blood Get access Michael Panaccio, Michael Panaccio Victorian Institute of Animal Science475 Mickleham Rd, Attwood, Victoria 3049, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Andrew Lew Andrew Lew Victorian Institute of Animal Science475 Mickleham Rd, Attwood, Victoria 3049, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 5, 11 March 1991, Page 1151, https://doi.org/10.1093/nar/19.5.1151 Published: 11 March 1991 Article history Accepted: 17 January 1991 Published: 11 March 1991
Effects of Bubble Cooling On Performance and Properties of Hmw-Hdpe Film Resins (1990)

In the blown film process, bubble cooling significantly impacts the ori entation of the film and plays an intergral role in the physical perfomance of the finished product. This study describes the effects of cooling on the processing param eters and physical properties of HMW-HDPE film resins The effects of fabrication with internal bubble cooling (IBC) versus non-IBC at various neck heights are also explored. Physical properties as well as process information are provided which focus on film properties in both IBC and non-IBC configurations
Improved annotation of the blogosphere via autotagging and hierarchical clustering (2006)

Tags have recently become popular as a means of annotating and organizing Web pages and blog entries. Advocates of tagging argue that the use of tags produces a 'folksonomy', a system in which the meaning of a tag is determined by its use among the community as a whole. We analyze the effectiveness of tags for classifying blog entries by gathering the top 350 tags from Technorati and measuring the similarity of all articles that share a tag. We find that tags are useful for grouping articles into broad categories, but less effective in indicating the particular content of an article. We then show that automatically extracting words deemed to be highly relevant can produce a more focused categorization of articles. We also show that clustering algorithms can be used to reconstruct a topical hierarchy among tags, and suggest that these approaches may be used to address some of the weaknesses in current tagging systems.
Severe factor VII deficiency caused by mutations abolishing the cleavage site for activation and altering binding to tissue factor (1994)

Factor VII (F.VII) is a vitamin-K-dependent serine protease required in the early stages of blood coagulation. We describe here a patient with severe F.VII deficiency, with a normal plasma F.VII antigen level (452 ng/mL) and F.VII activity less than 1%, who is homozygous for two defects: a G-->A transition at nucleotide 6055 in exon 4, which results in an Arg-->Gln change at amino acid 79 (R79Q); and a G-->A transition at nucleotide 8961 in exon 6, which results in an Arg-->Gln substitution at amino acid 152 (R152Q). The R79Q mutation occurs in the first epidermal growth factor (EGF)-like domain, which has previously been implicated in binding to tissue factor. The R152Q mutation occurs at a site (Arg 152-Ile 153) that is normally cleaved to generate activated F.VII (F.VIIa). Analysis of purified F.VII from patient plasma shows that the material cannot be activated by F.Xa and cofactors. In addition, in an in vitro binding assay using relipidated recombinant tissue factor, patient plasma showed markedly reduced binding to tissue factor at all concentrations tested. In an effort to separate the contributions of the two mutations, three recombinant variants, wild-type, R79Q, and R152Q, were prepared and analyzed. The R152Q variant had markedly reduced activity in a clotting assay, whereas R79Q showed a milder, concentration-dependent reduction. The R152Q variant exhibited nearly normal binding in the tissue factor binding assay, whereas the R79Q variant had markedly reduced binding. The time course of activation of the R79Q variant was slowed compared with wild-type. Our results suggest that the first EGF-like domain is required for binding to tissue factor and that the F.VII zymogen lacks activity and requires activation for expression of biologic activity.
Unamplified cap analysis of gene expression on a single-molecule sequencer (2011)

We report the development of a simplified cap analysis of gene expression (CAGE) protocol adapted for single-molecule sequencers that avoids second strand synthesis, ligation, digestion, and PCR. HeliScopeCAGE directly sequences the 3' end of cap trapped first-strand cDNAs. As with previous versions of CAGE, we better define transcription start sites (TSS) than known models, identify novel regions of transcription and alternative promoters, and find two major classes of TSS signal, sharp peaks and broad regions. However, using this protocol, we observe reproducible evidence of regulation at the much finer level of individual TSS positions. The libraries are quantitative over 5 orders of magnitude and highly reproducible (Pearson's correlation coefficient of 0.987). We have also scaled down the sample requirement to 5 μg of total RNA for a standard HeliScopeCAGE library and 100 ng for a low-quantity version. When the same RNA was run as 5-μg and 100-ng versions, the 100 ng was still able to detect expression for ∼60% of the 13,468 loci detected by a 5-μg library using the same threshold, allowing comparative analysis of even rare cell populations. Testing the protocol for differential gene expression measurements on triplicate HeLa and THP-1 samples, we find that the log fold change compared to Illumina microarray measurements is highly correlated (0.871). In addition, HeliScopeCAGE finds differential expression for thousands more loci including those with probes on the array. Finally, although the majority of tags are 5' associated, we also observe a low level of signal on exons that is useful for defining gene structures.
Overexpression of the receptor for hyaluronan-mediated motility, correlates with expression of microtubule-associated protein in human oral squamous cell carcinomas (2009)

Receptor for hyaluronan-mediated motility (RHAMM) has previously been characterized as a cell surface receptor for hyaluronan and a microtubule-associated intracellular hyaluronan binding protein. We examined the expression of RHAMM mRNA in 43 oral squamous cell carcinomas (SCCs) and 7 normal gingivae by real-time RT-PCR. The expression level of RHAMM mRNA was significantly higher in oral SCCs than normal gingivae (P=0.0047). Forty out of 43 oral SCCs showed expression of RHAMM splice variant (48 bp deletion). We immunohistochemically confirmed the protein expression of RHAMM in oral SCCs with higher levels of RHAMM mRNA. Patients with oral SCC who had high RHAMM expression had shorter survival rates than patients with low expression. However, it was not statistically significant. It has been reported that RHAMM interacts with spindle assembly factors such as microtubule-associated protein (TPX2). To investigate the expression of microtubule-associated protein in oral SCCs, mRNA expression of TPX2 was also examined by real-time RT-PCR. The expression level of TPX2 mRNA was significantly higher in oral SCCs than normal gingivae (P=0.046). Furthermore, a significant correlation between the mRNA expression levels of TPX2 and RHAMM was recognized (P=0.011). The results indicate that there is a strong correlation between the mRNA expression levels of TPX2 and RHAMM in oral SCCs. Our observations suggest that the up-regulations of human RHAMM and TPX2 gene correlate with the malignant condition and might be linked to the increased or abnormal cell proliferation in human oral SCCs.
B7-H4–deficient mice display augmented neutrophil-mediated innate immunity (2008)

B7-H4 is an immunoglobulin superfamily molecule and shown to be inhibitory for T-cell responses. To explore physiologic roles of B7-H4, we created B7-H4-deficient (KO) mice by genetic targeting. B7-H4KO mice are healthy and their T- and B-cell responses to polyclonal antigens are in normal range. However, B7-H4KO mice are more resistant to infection by Listeria monocytogenes than their littermates. Within 3 days after infection, bacterial colonies in livers and spleens are significantly lower than the controls, suggesting a role of B7-H4 in enhancing innate immunity. Further studies demonstrate that neutrophils increase in peripheral organs of B7-H4KO mice more so than their littermates but their bactericidal functions remain unchanged. Augmented innate resistance is completely dependent on neutrophils, even in the absence of adaptive immunity. In vitro B7-H4 inhibits the growth of bone marrow-derived neutrophil progenitors, suggesting an inhibitory function of B7-H4 in neutrophil expansion. Our results identify B7-H4 as a negative regulator of the neutrophil response to infection and provide a new target for manipulation of innate immunity.
Data and computation transformations for multiprocessors (1995)

Effective memory hierarchy utilization is critical to the performance of modern multiprocessor architectures. We have developed the first compiler system that fully automatically parallelizes sequential programs and changes the original array layouts to improve memory system performance. Our optimization algorithm consists of two steps. The first step chooses the parallelization and computation assignment such that synchronization and data sharing are minimized. The second step then restructures the layout of the data in the shared address space with an algorithm that is based on a new data transformation framework. We ran our compiler on a set of application programs and measured their performance on the Stanford DASH multiprocessor. Our results show that the compiler can effectively optimize parallelism in conjunction with memory subsystem performance.
Keratinocyte growth factor-2 (FGF-10) promotes healing of experimental small intestinal ulceration in rats (2000)

Keratinocyte growth factor-2 (KGF-2, repifermin) is a homolog of KGF-1 with epithelial mitogenic activities. We investigated the therapeutic role of KGF-2 in intestinal ulceration and its mechanisms of protection. KGF-2 (0.3-5 mg/kg) was administered before or after induction of small intestinal ulceration by indomethacin (Indo) in prevention and treatment protocols. In acute studies, KGF-2 was injected for up to 7 days before or daily for 5 days after Indo. In a 15-day chronic study, KGF-2 was injected intravenously daily beginning before or 7 days after Indo. Injury was evaluated by blinded macroscopic and microscopic inflammatory scores, epithelial BrdU staining, tissue IL-1beta, PGE(2), and hydroxyproline concentrations, and collagen type I RNA expression. In vitro effects of KGF-2 were evaluated by epithelial cellular proliferation, restitution of wounded monolayers, PGE(2) secretion, and expression of COX-2 and collagen mRNA. Intravenous KGF-2 significantly decreased acute intestinal injury by all parameters and significantly decreased chronic ulceration. Pretreatment, daily infusion, and delayed treatment were effective. KGF-2 promoted in vitro epithelial restitution with only modest effects on epithelial cell proliferation, stimulated COX-2 expression in cultured epithelial cells, and upregulated in vitro and in vivo PGE(2) production. KGF-2 did not affect in vivo fibrosis, although it induced collagen expression in cultured intestinal myofibroblasts. These results suggest that KGF-2 inhibits intestinal inflammation by stimulating epithelial restitution and protective PGs.
Effect of the Modified Lapidus Procedure for Hallux Valgus on Foot Width (2019)

Level III, comparative series.
Efficacy of Coenzyme Q10 for Improved Tolerability of Cancer Treatments: A Systematic Review (2004)

Suggestions that CoQ10 might reduce the toxicity of cancer treatments have not been tested by rigorous trials. Further investigations are necessary to determine whether CoQ10 can improve the tolerability of cancer treatments.
Commercially available blood storage containers (2013)

Plastic blood bags improve the safety and effectiveness of blood component separation and storage. Progress towards optimal storage systems is driven by medical, scientific, business and environmental concerns and is limited by available materials, consumer acceptance and manufacturing and regulatory concerns. Blood bag manufacturers were invited to submit lists of the bags they manufacture. The lists were combined and sorted by planned use. The lists were analysed by experts to assess the degree to which the products attend to scientific problems. Specific issues addressed included the use of di-ethylhexyl phthalate (DEHP) as plasticizer for polyvinyl chloride (PVC) blood bags, the size, material and thickness of platelet bags, and the fracture resistance of plasma bags. Alternatives to DEHP for red blood cell (RBC) storage exist, but are mostly in a developmental stage. Plastic bags (DEHP-free, PVC-free) for platelet storage with better gas diffusion capabilities are widely available. Alternatives for plasma storage with better fracture resistance at low temperatures exist. Most RBC products are stored in DEHP-plasticized PVC as no fully satisfactory alternative exists that ensures adequate storage with low haemolysis. A variety of alternative platelet storage systems are available, but their significance - other than improved oxygen transport - is poorly understood. The necessity to remove DEHP from blood bags still needs to be determined.
Antibody-based targeting of interferon-alpha to the tumor neovasculature: a critical evaluation (2011)

The antibody-mediated targeted delivery of cytokines, growth factors and immunomodulators offers great potential for the therapy of cancer and other serious conditions. Interferon-alpha has long been used in the clinic for the treatment of patients with certain malignancies or with viral disease. Promising anticancer activity has recently been reported for two fusion proteins consisting of immunoglobulins bearing the interferon-alpha polypeptide at the C-terminal end of the molecule. Here we describe the design, production and characterization of a novel immunocytokine, in which murine interferon-alpha2 was sequentially fused with the tumor-targeting antibody fragment scFv(F8), specific to the alternatively-spliced EDA domain of fibronectin. The resulting fusion protein (F8-IFNa) could be produced to homogeneity and was shown to retain both antigen binding activity and interferon-alpha activity. Biodistribution studies in tumor-bearing mice with radioiodinated protein preparations confirmed the ability of F8-IFNa to selectively localize at the tumor site. However, using two different murine models of cancer (F9 teratocarcinomas and Cloudman S91 melanomas in immunocompetent mice), we could not detect a striking superiority for the therapeutic performance of F8-IFNa as compared to KSF-IFNa, a fusion protein of irrelevant specificity in the mouse which was used as negative control. In the paper, we present hypotheses why the antibody-based pharmacodelivery of interferon-alpha fails to eradicate tumors, in contrast to the situation observed by our group for other immunocytokines, which benefit from a selective localization at the tumor site.
At-speed BIST for interposer wires supporting on-the-spot diagnosis (2013)

Testing the speed of post-bond interposer wires in a 2.5-D stacked IC is essential for silicon debugging, yield learning, and even for fault tolerance. In this paper, we present a novel at-speed test technique called Pulse-Vanishing test (PV-test), in which a short-duration pulse signal is applied to an interposer wire under test at the d river end. If the pulse signal can successfully propagate through the interposer wire and reach the other end, then the interposer wire is considered fault-free. Otherwise, it indicates the presence of a delay fault. This new test technique has several technical merits. For example, the Design-for-Testability (DfT) circuit for an interposer wire is similar to the boundary scan cell and can be controlled through scan chain. Also, it can be easily adapted to perform at-speed Built-In Self-Test (BIST) supporting on-the-spot diagnosis.
Bioactive Microbial Products: Focus Upon Mechanism Of Action (1990)

Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly pathogenic HCoVs: severe acute respiratory syndrome coronavirus (SARS-CoV) and ...Read More
Improving the toxicity of irinotecan/5-FU/leucovorin: a 21-day schedule. (2003)

Irinotecan (CPT-11, Camptosar) is one of the new generation of chemotherapeutic agents that has activity in advanced colorectal cancer. It has antitumor efficacy as a single agent, and also has been combined with fluorouracil (5-FU) and leucovorin (IFL) to treat these patients. Randomized studies have confirmed the superiority of IFL to 5-FU and leucovorin alone with regard to patient survival, time to progression, and tumor response rate. The optimal schedule for combining these agents remains uncertain, but in the United States, the schedule of IFL weekly for 4 consecutive weeks repeated every 6 weeks, according to the schedule reported by Saltz et al, has been widely used, although with some toxicity (especially myelosuppression and diarrhea). In an attempt to improve the tolerability of IFL, some have advocated modifying the schedule of IFL to weekly for 2 weeks, with repeated cycles every 21 days. Twenty-three patients with advanced colorectal cancer have been treated on this schedule at a single institution. Therapy was well tolerated, with 35% of patients experiencing grade 3/4 neutropenia, two of whom had episodes of febrile neutropenia, and 9% with grade 3/4 diarrhea. The median relative dose intensity of irinotecan administered in the first 18 patients treated with this regimen was 94%. These data support the hypothesis that modifying the schedule of administration of IFL improves the tolerability and ability to deliver the regimen, but must be confirmed by randomized prospective studies, which may also attempt to evaluate the role of bolus 5-FU in the treatment of advanced colorectal cancer.
Multiple retinoid-responsive receptors in a single cell: families of retinoid "X" receptors and retinoic acid receptors in the Xenopus egg. (1992)

In a search for nuclear hormone receptors expressed in early development we found that Xenopus laevis eggs contain mRNAs from two retinoic acid receptor genes (xRAR alpha and xRAR gamma) and two retinoid "X" receptor genes (xRXR alpha and xRXR gamma). We also show that RXRs are members of a family of at least three genes, thus expanding the number of genes encoding retinoic acid-responsive transcription factors to six. With the exception of xRXR gamma, these maternal mRNAs are degraded before gastrulation. The RXRs isolated are differentially activated by retinoic acid and by 3,4-didehydroretinoic acid. Considered together, these four receptors provide a molecular basis for the pleiotropic effects of retinoic acid on early development, and their pattern of expression suggests a role for retinoic acid at the earliest stages of embryonic determination.
Interpretation and Classification of Microvolt T Wave Alternans Tests (2002)

Measurement of microvolt-level T wave alternans (TWA) during routine exercise stress testing now is possible as a result of sophisticated noise reduction techniques and analytic methods that have become commercially available. Even though this technology is new, the available data suggest that microvolt TWA is a potent predictor of arrhythmia risk in diverse disease states. As this technology becomes more widely available, physicians will be called upon to interpret microvolt TWA tracings. This review seeks to establish uniform standards for the clinical interpretation of microvolt TWA tracings.
Self-deployable current sources fabricated from edible materials (2013)

Flexible biodegradable electronics have the potential to serve as the centerpiece for temporary electronically active medical implants. Biodegradable electronics may exhibit many advantages over traditional chronic implants. Two important long-term goals for biodegradable electronics are (1) supplying sufficient power and (2) reducing the invasiveness of device deployment. Edible electronic devices are capable of addressing both challenges. Here, we introduce electrochemical electronic power sources that are compatible with non-invasive deployment strategies and are composed entirely of edible materials and naturally occurring precursors that are consumed in common diets. The current sources developed herein are powered by onboard sodium ion electrochemical cells. Potentials up to 0.6 V and currents in the range of 5-20 μA can be generated routinely. These devices could serve as an enabling platform technology for edible electronics used in non-invasive sensing and stimulation of tissues within the human body.