gebhart/patrepeval huggingface dataset:
Synthesis of the Fjord-region cis- and trans-Amino Triol Derivatives of the Carcinogenic Hydrocarbon Benzo[g]chrysene and Utilization for the Synthesis of a Deoxyadenosine Adduct Linked to the N6-Amino Group (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of the Fjord-region cis- and trans-Amino Triol Derivatives of the Carcinogenic Hydrocarbon Benzo[g]chrysene and Utilization for the Synthesis of a Deoxyadenosine Adduct Linked to the N6-Amino GroupAlexander S. Kiselyov, Thomas Steinbrecher, and Ronald G. HarveyCite this: J. Org. Chem. 1995, 60, 19, 6129–6134Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/jo00124a027https://doi.org/10.1021/jo00124a027research-articleACS PublicationsRequest reuse permissionsArticle Views182Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Activation of coagulation factor VII during alimentary lipemia. (1994)

Dietary studies have established a connection between plasma lipoproteins and coagulation factor VII. The present study was undertaken to specifically examine whether factor VII is activated during alimentary lipemia and to investigate the relations of factor VII mass and activity state with fasting and postprandial lipoproteins and free fatty acids (FFAs). Factor VII levels were therefore determined in plasma samples taken before and after intake of a standardized, oral fat load of a mixed-meal type in 33 men (mean age +/- SD, 48.8 +/- 3.2 years) with a previous myocardial infarction at a young age and 10 healthy, age-matched control subjects. A panel of methods for factor VII determination was used to ensure that changes in all potentially existing forms of the factor during alimentary lipemia would be included. Substantial activation of factor VII was found to occur during alimentary lipemia, whereas the number of factor VII molecules remained constant or even appeared to decrease after the test meal. Activation of factor VII was more pronounced in control subjects than patients, and the proportion of activated factor VII molecules was higher in control subjects. Interestingly, factor VII activation, which correlated quantitatively with the degree of postprandial triglyceridemia, seemed to be related to FFA production during lipolysis of triglyceride-rich lipoproteins that were generated in response to fat intake. Postheparin plasma lipoprotein lipase activity was lower in patients, which could offer one explanation why factor VII activity was lower during alimentary lipemia in these subjects despite their exaggerated postprandial triglyceridemia. Thus, activation of coagulation factor VII during alimentary lipemia may result in a procoagulant state that is likely to promote the formation of a coronary thrombus in individuals with established coronary artery disease.
The Frog-leg Lateral Radiograph Accurately Visualized Hip Cam Impingement Abnormalities (2007)

Radiographic evaluation of the anterolateral femoral head-neck junction is essential in diagnosing cam femoroacetabular impingement. We hypothesized the frog-leg lateral radiograph can accurately assess femoral head-neck offset abnormalities associated with cam femoroacetabular impingement. We reviewed the radiographs of 61 hips treated for cam impingement and 24 asymptomatic control hips. To characterize the anatomy of the femoral head-neck junction, the femoral head sphericity, the alpha-angle of Nötzli et al, and head-neck offset were measured on all radiographs. Asphericity of the femoral head was detected more frequently in hips with impingement on all radiographic views when compared with control hips. The average alpha-angle was greater in hips with impingement on all views, with the greatest difference between hips with impingement and control hips seen on the frog-leg lateral view (65 degrees for hips with impingement versus 47 degrees for control hips). The average head-neck offset was decreased in hips with impingement on all views. The greatest difference between groups was seen on the frog-leg lateral view (6.6 mm for hips with impingement versus 9.3 mm for control hips). The frog-leg lateral radiograph provides accurate visualization of the femoral head-neck offset in patients being evaluated for femoroacetabular impingement.
A phase I, first-in-human study to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of IMGN853 in patients (Pts) with epithelial ovarian cancer (EOC) and other FOLR1-positive solid tumors. (2013)

2573 Background: IMGN853 is an antibody-drug conjugate (ADC) comprising a folate receptor 1 (FOLR1)-binding antibody and the potent maytansinoid, DM4. FOLR1 is over-expressed on many solid tumors, particularly EOC, endometrial cancer, non-small cell lung cancer (NSCLC), and clear-cell renal cell cancer. Methods: The primary study objectives are to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D). Secondary objectives include evaluation of safety, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy. In dose escalation, patients with any type of FOLR1-expressing, refractory solid tumor may be enrolled. Once the MTD is defined, 3 expansion cohorts will evaluate patients with (1) primary platinum refractory or resistant EOC; (2) relapsed/refractory EOC, amenable to biopsy, and (3) relapsed/refractory NSCLC. Cohorts 2 and 3 will have IMGN853 PD assessment by pre-and post-dose tumor biopsy and by FLT-PET imaging, respectively. IMGN853 is given intravenously (IV) on Day 1 of each 21-day cycle. During dose escalation, an accelerated titration design was used. Responses are assessed using RECIST and GCIG criteria (as appropriate). Results: Eleven patients have been enrolled across 6 dose levels ranging from 0.15 to 5.0 mg/kg: 7 patients with EOC and 4 patients with endometrial cancer. No study drug-related serious adverse events (SAEs) or dose-limiting toxicity (DLT) have been reported. Among these 11 patients, 3 patients reported adverse events (AEs) considered study drug related; these were mild or moderate. At the 3.3 mg/kg dose level, one patient with serous EOC had an 82% reduction in CA125 (confirmation pending). The other 2 patients at this dose level, one with EOC and one with endometrial cancer, have stable disease. Drug exposure has been measured in 8 patients and has been found to generally increase linearly, with a half life at 3.3 mg/kg (3 patients) of approximately 4 days. Conclusions: IMGN853 is well tolerated at doses up to 3.3 mg/kg. Safety evaluation continues at 5 mg/kg and dose escalation is ongoing. Clinical trial information: NCT01609556.
PAX genes in development and disease: the role of PAX2 in urogenital tract development (2002)

PAX genes play an important role in fetal development. Moreover, heterozygous mutations in several PAX genes cause human disease. Here we review the role of PAX2 in kidney development, focusing on the morphological effects of PAX2 mutations. We discuss the role of PAX2 in the context of an inhibitory field model of kidney branching morphogenesis and summarize recent progress in this area.
Monoclonal antibody-superantigen fusion proteins: tumor-specific agents for T-cell-based tumor therapy. (1994)

The bacterial superantigen staphylococcal enterotoxin A (SEA) is an extremely potent activator of T lymphocytes when presented on major histocompatibility complex (MHC) class II molecules. To develop a tumor-specific superantigen for cancer therapy, we have made a recombinant fusion protein of SEA and the Fab region of the C215 monoclonal antibody specific for human colon carcinoma cells. SEA as part of a fusion protein showed a > 10-fold reduction in MHC class II binding compared to native SEA, and accordingly, the affinity of the FabC215-SEA fusion protein for the C215 tumor antigen was approximately 100-fold stronger than to MHC class II molecules. The FabC215-SEA fusion protein efficiently targeted T cells to lyse C215+ MHC class II- human colon carcinoma cells, which demonstrates functional substitution of the MHC class II-dependent presentation of SEA with tumor specificity. Treatment of mice carrying B16 melanoma cells expressing a transfected C215 antigen resulted in 85-99% inhibition of tumor growth and allowed long-term survival of animals. The therapeutic effect was dependent on antigen-specific targeting of the FabC215-SEA fusion protein, since native SEA and an antigen-irrelevant FabC242-SEA fusion protein did not influence tumor growth. The results suggest that Fab-SEA fusion proteins convey superantigenicity on tumor cells, which evokes T cells to suppress tumor growth.
Automatic essay scoring with recurrent neural network (2019)

As deep learning has developed rapidly in recent years, the automatic essay scoring system, based on deep learning models, has become more reliable than previous feature-based systems. Recent researchers have developed an approach based on recurrent neural networks to learn the relationship between an essay and its assigned score, without any feature engineering. In this paper, we use an ASAP essay dataset, combining feature scoring and a recurrent neural network. The results show that we can compare the result of quadratic weighted Kappa of each experience to get the best model. GloVe significantly improves the results, and feature extraction can affect the result slightly. In future work, we will apply transfer learning, one-shot learning, and adversarial inputs in our model to get better performance.
Surface Characterization of Advanced Polymers (1993)

Spectroscopies for surface characterization electron induced vibrational spectrosocopy (HREELS) time-of-flight secondary ions mass spectrometry investigation of advanced polymers by ions scattering spectrosocopy (ISS) X-ray photoelectron spectroscopy analysis of conducting polymers chemical derivatization methods for enhancing the analytical capabilities of X-ray photoelectron spectroscopy and static secondary ion mass spectrometry data analysis and treatment in XPS.
Simple procedure of DNA isolation from human serum (1991)

Journal Article Simple procedure of DNA isolation from human serum Get access Masaki Ishizawa, Masaki Ishizawa Search for other works by this author on: Oxford Academic PubMed Google Scholar Y. Kobayashi, Y. Kobayashi * * To whome correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar T. Miyamura, T. Miyamura 1Department of Enteroviruses, national Institute of Healthat kamiosaki 2–10–35, Shinagawa-ku, Tokyo 141, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Matsura S. Matsura Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 20, 25 October 1991, Page 5792, https://doi.org/10.1093/nar/19.20.5792 Published: 25 October 1991 Article history Received: 13 August 1991 Published: 25 October 1991
Attainment of minimal biological variability and measurements of genotoxicity: production of homozygous diploid zebra fish. (1984)

Zebra fish (Brachydanio rerio) are particularly suited for carcinogenicity testing and for the establishment of quantitative dose-response relationships. They are small, prolific, have short generation times, and produce eggs which develop synchronously and can be treated at identical developmental stages. Clones of homozygotes with minimal genetic variability provide a reproducible biological test system. Rapid measurements of the frequency of induced somatic mosaicism (demonstrated with gamma radiation, ethyl methanesulfonate, and ethylnitrosourea) and induced germ-line recessive-lethal mutation provide indexes of exposure.
Molecular and Cellular Biology of Mast Cells and Basophils (1997)

In all mammalian species investigated so far, mast cells and basophils are the only cells that synthesize histamine and express plasma membrane receptors that bind IgE with high affinity (Fc epsilonRI). Human basophils and mast cells derive from distinct precursors that originate in the bone marrow and fetal liver and probably circulate in peripheral blood. There is extensive evidence that mast cells and basophils and their mediators are primary effectors of allergic inflammation. Immunologically activated human basophils release two cytokines: IL-4 and IL-13. Expression of several cytokines has been documented in a number of experimental models of human and rodent mast cells. However, to date few studies have analyzed the mechanisms of gene expression in human Fc epsilonRI+ cells. Some of these studies imply a role for NFAT and GATA family members in the IgE-mediated activation of cytokine gene transcription in basophils and mast cells. Studies of human basophils and mast cells isolated from different anatomic sites have established the different profiles of eicosanoids released by these cells. Recently, the characterization of arachidonic acid pools and the identification of novel enzymes involved in arachidonate remodeling and mobilization clarified in part how eicosanoid productions is regulated in mast cells and basophils. In addition to histamine, human mast cell secretory granules contain the neutral proteases tryptase, chymase and carboxypeptidase that possess several biochemical properties. In particular, tryptase may play a role as a fibrogenic factor and chymase might convert angiotensin I to angiotensin II. Mast cells are present in human heart and in human coronary arteries raising the possibility that local activation of cardiac mast cells might contribute to certain cardiovascular diseases. Recent evidence also suggests that mast cells and basophils can play a role during viral and bacterial infections. It is now evident that in man these two cells not only participate in inflammation associated with allergic disease, but also in chronic and fibrotic disorders affecting several organs and in host defense against bacterial and viral infections.
A Novel Isoenzyme of Ascorbate Peroxidase Localized on Glyoxysomal and Leaf Peroxisomal Membranes in Pumpkin (1995)

A novel isoenzyme of ascorbate peroxidase with molecular mass of 31 kDa was found to be localized on membranes of microbodies. Intact microbodies had no latent ascorbate peroxidase activity, an indication that the active site of the ascorbate peroxidase was exposed to the cytosol and the peroxidase would scavenge hydrogen peroxide leaked from microbodies.
Synthesis of the Quinolone ABT-492:  Crystallizations for Optimal Processing (2006)

ABT-492 has been under development at Abbott Laboratories as a quinolone antibiotic. A convergent syntheses was utilized to prepare the compound on a multi-kilogram scale. Difficulties in isolation of intermediates were overcome by developing control of the physical forms. Examples of controlling the agglomeration, crystal habit, and polymorphism of intermediates and the API are described.
Expression of retinoblastoma gene product (pRb) in mantle cell lymphomas. Correlation with cyclin D1 (PRAD1/CCND1) mRNA levels and proliferative activity. (1996)

Mantle cell lymphomas (MCLs) are molecularly characterized by bcl-1 rearrangement and constant cyclin D1 (PRAD-1/CCND1) gene overexpression. Cyclin D1 is a G1 cyclin that participates in the control of the cell cycle progression by interacting with the retinoblastoma gene product (pRb). Inactivation of the Rb tumor suppressor gene has been implicated in the development of different types of human tumors including some high grade non-Hodgkin's lymphomas. To determine the role of the retinoblastoma gene in the pathogenesis of MCLs and its possible interaction with cyclin D1, pRb expression was examined in 23 MCLs including 17 typical and 6 blastic variants by immunohistochemistry and Western blot. Rb gene structure was studied in 13 cases by Southern blot. Cytogenetic analysis was performed in 5 cases. The results were compared with the cyclin D1 mRNA levels examined by Northern analysis, and the proliferative activity of the tumors was measured by Ki-67 growth fraction and flow cytometry. pRb was expressed in all MCLs. The expression varied from case to case (mean, 14.1% of positive cells; range, 1.3 to 42%) with a significant correlation with the proliferative activity of the tumors (mitotic index r = 0.85; Ki-67 r = 0.7; S phase = 0.73). Blastic variants showed higher numbers of pRb-positive cells (mean, 29%) than the typical cases (10%; P < 0.005) by immunohistochemistry and, concordantly, higher levels of expression by Western blot. In addition, the blastic cases also had an increased expression of the phosphorylated protein. No alterations in Rb gene structure were observed by Southern blot analysis. Cyclin D1 mRNA levels were independent of pRb expression and the proliferative activity of the tumors. These findings suggest that pRb in MCLs is normally regulated in relation to the proliferative activity of the tumors. Cyclin D1 overexpression may play a role in the maintenance of cell proliferation by overcoming the suppressive growth control of pRb.
An additive reliability model for the analysis of modular software failure data (2002)

Most software reliability models are applicable to a single piece of software. For more complex systems, Markov models have been studied assuming that complete reliability information at the module level is available. We study an additive model which assumes that each subsystem or module undergoes independent testing and the reliability of the complete system has to be assessed. Subsystem reliabilities are estimated and the system reliability is assessed using the additive model. The approach is simple, but generic in a sense that existing models can be combined. An example is also presented based on the log-power-model, a model with simple graphical interpretation and it shows that the modular information should be used for system reliability assessment whenever such information is available.
Combinatorial algorithms for structural variation detection in high-throughput sequenced genomes (2009)

Recent studies show that along with single nucleotide polymorphisms and small indels, larger structural variants among human individuals are common. The Human Genome Structural Variation Project aims to identify and classify deletions, insertions, and inversions (>5 Kbp) in a small number of normal individuals with a fosmid-based paired-end sequencing approach using traditional sequencing technologies. The realization of new ultra-high-throughput sequencing platforms now makes it feasible to detect the full spectrum of genomic variation among many individual genomes, including cancer patients and others suffering from diseases of genomic origin. Unfortunately, existing algorithms for identifying structural variation (SV) among individuals have not been designed to handle the short read lengths and the errors implied by the "next-gen" sequencing (NGS) technologies. In this paper, we give combinatorial formulations for the SV detection between a reference genome sequence and a next-gen-based, paired-end, whole genome shotgun-sequenced individual. We describe efficient algorithms for each of the formulations we give, which all turn out to be fast and quite reliable; they are also applicable to all next-gen sequencing methods (Illumina, 454 Life Sciences [Roche], ABI SOLiD, etc.) and traditional capillary sequencing technology. We apply our algorithms to identify SV among individual genomes very recently sequenced by Illumina technology.
Varroa destructor changes its cuticular hydrocarbons to mimic new hosts (2015)

Varroa destructor (Vd) is a honeybee ectoparasite. Its original host is the Asian honeybee, Apis cerana, but it has also become a severe, global threat to the European honeybee, Apis mellifera. Previous studies have shown that Varroa can mimic a host's cuticular hydrocarbons (HC), enabling the parasite to escape the hygienic behaviour of the host honeybees. By transferring mites between the two honeybee species, we further demonstrate that Vd is able to mimic the cuticular HC of a novel host species when artificially transferred to this new host. Mites originally from A. cerana are more efficient than mites from A. mellifera in mimicking HC of both A. cerana and A. mellifera. This remarkable adaptability may explain their relatively recent host-shift from A. cerana to A. mellifera.
Reactivities of organolithium compounds in tetrahydrofuran. I. As vinyl polymerization initiators (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactivities of organolithium compounds in tetrahydrofuran. I. As vinyl polymerization initiatorsRichard Waack and Mary A. DoranCite this: J. Org. Chem. 1967, 32, 11, 3395–3399Publication Date (Print):November 1, 1967Publication History Published online1 May 2002Published inissue 1 November 1967https://pubs.acs.org/doi/10.1021/jo01286a026https://doi.org/10.1021/jo01286a026research-articleACS PublicationsRequest reuse permissionsArticle Views396Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High Catalytic Activities of Pseudoliquid Phase of Dodecatungstophosphoric Acid for Reactions of Polar Molecules (1991)

Abstract A solid H3PW12O40 exhibited very high catalytic activities for the reactions of polar molecules in the liquid phase, while it was much less active for the reactions of nonpolar molecules. It was confirmed that the pseudoliquid phase behavior of H3PW12O40 is responsible for the high activities.
Circulating Adiponectin Is Inversely Associated with Risk of Thyroid Cancer:In Vivoandin VitroStudies (2011)

Circulating adiponectin is independently and inversely associated with the risk of thyroid cancer. Human thyroid carcinomas and cell lines express adiponectin receptors. However, in the absence of a major direct effect of adiponectin on thyroid cancer cell lines in vitro, the negative association observed herein may be attributed to the metabolic effects of adiponectin.