gebhart/patrepeval huggingface dataset:
Radiolabeled antibody targeting of the HER-2/neu oncoprotein. (1992)

The HER-2/neu oncogene encodes a Mr 185,000 transmembrane phosphoglycoprotein which is overexpressed in 25-35% of breast and ovarian neoplasms and portends a poor prognosis. We have studied the feasibility of targeting this oncoprotein, designated p185, with radioiodinated murine monoclonal antibodies (muMABs) 4D5 and 7C2, which recognize distinct epitopes on its extracellular domain. The rates of internalization and catabolism of these antibodies were analyzed by cellular radioimmunoassay and electron microscopy. After binding to NIH3T3 HER-2/neu cells, which show high surface expression of p185, the muMABs were endocytosed via coated pits, routed to lysosomes, and degraded. Approximately 44% of 125I-4D5 and 39% of 125I-7C2 were catabolized by tumor cells after 24 h. The biodistribution of radiolabeled 4D5 and 7C2 were evaluated in beige/nude mice bearing s.c. NIH3T3 HER-2/neu grafts. A high specificity of localization was seen with tumor:organ ratios of activity generally ranging from 5:1 to 30:1. However, the percentage injected dose of radioactivity per gram of tumor declined sharply from 25% at 24 h to 5% at 120 h postinjection. Treating the animals with 400-700 muCi 131I-4D5 caused a marked inhibition of tumor growth, although no mice were cured. Unlabeled 4D5 had no effect on tumor progression in this model, but administering 400-700 muCi of 131I-DA4-4, an isotype-matched irrelevant muMAB, resulted in an intermediate degree of growth retardation. Analysis of kinetic blood data and whole-body time-activity curves indicated that the irrelevant conjugate remained in the body 2-3 times longer than 131I-4D5. Radioiodinated anti-HER-2/neu muMABs are attractive agents for radioimmunodiagnosis and radioimmunotherapy of aggressive HER-2/neu-positive breast and ovarian carcinomas, but effective strategies for retarding intratumoral catabolism may be necessary to optimize their clinical utility.
Gold(I)-Catalyzed Regioselective Inter-/Intramolecular Addition Cascade of Di- and Triynes for Direct Construction of Substituted Naphthalenes (2012)

The gold-catalyzed cascade intermolecular addition-intramolecular carbocyclization reaction of dialkynylbenzenes was developed. In this reaction, regioselective addition of an external nucleophile toward the terminal alkyne and subsequent 6-endo-dig cyclization proceeded to give the 1,3-disubstituted naphthalenes in good yields. The direct synthesis of disubstituted chrysenes via a gold-catalyzed addition and double cyclization cascade using a triyne-type substrate was also achieved.
Nucleotide sequence of crystal protein gene isolated from B.thuringiensis subspecies entomocidus 60.5 coding for a toxin highly active against Spodoptera species (1988)

Journal Article Nucleotide sequence of crystal protein gene isolated from B.thuringiensis subspecies entomocidus 60.5 coding for a toxin highly active against Spodoptera species Get access Guy Honée, Guy Honée Research Institute ItalPO Box 48, 6700 AA Wageningen, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar Theo Van der Salm, Theo Van der Salm Research Institute ItalPO Box 48, 6700 AA Wageningen, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar Bert Visser Bert Visser Research Institute ItalPO Box 48, 6700 AA Wageningen, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 13, 11 July 1988, Page 6240, https://doi.org/10.1093/nar/16.13.6240 Published: 11 July 1988 Article history Received: 13 May 1988 Published: 11 July 1988
Multi-region reduced field testing (RFT) for matrix thinning (1996)

The reduced field testing (RFT) method has been proposed recently as a means to generate a sparse matrix for surface formulation within the method of moments (MoM). The method is based on the distinction between near field and far field interactions, where the far field interactions are treated in a more economical way than near field interactions by relying on the difference in sampling rates between the near and far field interaction regions. It is formulated directly in the spatial domain unlike the spectral domain FMM, and it provides a single, explicit sparse matrix invertible by either direct or iterative methods. The original version of the RFT was based on the division of space into two such regions, whereas in the context of this work we show a multi-region arrangement, as well as documentation of substantial saving in running times. The performance of the method for two dimensional cases is demonstrated.
Neuropsychiatric symptoms in Alzheimer's disease (2011)

Neuropsychiatric symptoms (NPS) are core features of Alzheimer's disease and related dementias. Once thought to emerge primarily in people with late-stage disease, these symptoms are currently known to manifest commonly in very early disease and in prodromal phases, such as mild cognitive impairment. Despite decades of research, reliable treatments for dementia-associated NPS have not been found, and those that are in widespread use present notable risks for people using these medications. An Alzheimer's Association Research Roundtable was convened in the spring of 2010 to review what is known about NPS in Alzheimer's disease, to discuss classification and underlying neuropathogenesis and vulnerabilities, and to formulate recommendations for new approaches to tailored therapeutics.
Photolysis of alkyl 4-nitrobenzenesulfenates. A new and versatile method for the generation of free radicals (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotolysis of alkyl 4-nitrobenzenesulfenates. A new and versatile method for the generation of free radicalsDaniel J. Pasto and Gael L'HermineCite this: J. Org. Chem. 1990, 55, 23, 5815–5816Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/jo00310a008https://doi.org/10.1021/jo00310a008research-articleACS PublicationsRequest reuse permissionsArticle Views168Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Low-Temperature Solution Route to Macroscopic Amounts of Hydrogen Terminated Silicon Nanoparticles (2006)

A new solution route for preparing gram-scale, hydrogen terminated silicon nanoparticles is presented. Dimethoxyethane and diocytl ether have been used to prepare silicon nanoparticles via a solution reaction between sodium silicide and ammonium bromide. The reaction products are isolated as a clear yellow-orange solution and a dark black powder. Both the solution and the powder have been characterized.
Controlling the porosity of fibrous scaffolds by modulating the fiber diameter and packing density (2011)

Porosity has been shown to be a key determinant of the success of tissue engineered scaffolds. A high degree of porosity and an appropriate pore size are necessary to provide adequate space for cell spreading and migration as well as to allow for proper exchange of nutrients and waste between the scaffold and the surrounding environment. Electrospun scaffolds offer an attractive approach for mimicking the natural extracellular matrix (ECM) for tissue engineering applications. The efficacy of electrospinning is likely to depend on the interaction between cells and the geometric features and physicochemical composition of the scaffold. A major problem in electrospinning is the tendency of fibers to accumulate densely, resulting in poor porosity and small pore size. The porosity and pore sizes in the electrospun scaffolds are mainly dependent on the fiber diameter and their packing density. Here we report a method of modulating porosity in three dimensional (3D) scaffolds by simultaneously tuning the fiber diameter and the fiber packing density. Nonwoven poly(ε-caprolactone) mats were formed by electrospinning under various conditions to generate sparse or highly dense micro- and nanofibrous scaffolds and characterized for their physicochemical and biological properties. We found that microfibers with low packing density resulted in improved cell viability, proliferation and infiltration compared to tightly packed scaffolds.
Enterovirus Déjà Vu (2007)

More than 90 human enterovirus serotypes have now been identified in three distinct waves of discovery. The three poliovirus serotypes were first isolated from nonhuman primates in the course of painstaking experiments performed during the first half of the 20th century. The use of small laboratory animals and the advent of cell culture in midcentury led to the description of 61 more enteroviruses that we know as coxsackieviruses, echoviruses, and the “newer” enteroviruses. The application of polymerase chain reaction and genomic sequencing has recently permitted characterization of approximately 30 previously unidentified enterovirus serotypes and undoubtedly will uncover more.Enterovirus 71 . . .
Post-stroke cognitive impairment: epidemiology, mechanisms and management. (2014)

Post-stroke cognitive impairment occurs frequently in the patients with stroke. The prevalence of post-stroke cognitive impairment ranges from 20% to 80%, which varies for the difference between the countries, the races, and the diagnostic criteria. The risk of post-stroke cognitive impairment is related to both the demographic factors like age, education and occupation and vascular factors. The underlying mechanisms of post-stroke cognitive impairment are not known in detail. However, the neuroanatomical lesions caused by the stroke on strategic areas such as the hippocampus and the white matter lesions (WMLs), the cerebral microbleeds (CMBs) due to the small cerebrovascular diseases and the mixed AD with stroke, alone or in combination, contribute to the pathogenesis of post-stroke cognitive impairment. The treatment of post-stroke cognitive impairment may benefit not only from the anti-dementia drugs, but also the manage measures on cerebrovascular diseases. In this review, we will describe the epidemiological features and the mechanisms of post-stroke cognitive impairment, and discuss the promising management strategies for these patients.
Efficient breakout routing in printed circuit boards (1997)

Article Efficient breakout routing in printed circuit boards Share on Authors: John Hershberger Mentor Graphics, 1001 Ridder Park Drive, San Jose, CA Mentor Graphics, 1001 Ridder Park Drive, San Jose, CAView Profile , Subhash Suri Department of Computer Science, Washington University, St. Louis, MO Department of Computer Science, Washington University, St. Louis, MOView Profile Authors Info & Claims SCG '97: Proceedings of the thirteenth annual symposium on Computational geometryAugust 1997 Pages 460–462https://doi.org/10.1145/262839.263082Online:01 August 1997Publication History 9citation256DownloadsMetricsTotal Citations9Total Downloads256Last 12 Months5Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Supercoil-induced extrusion of a regulatory DNA hairpin (1997)

Bacteriophage N4 virion RNA polymerase (N4 vRNAP) promoters contain inverted repeats, which form a 5- to 7-base-pair stem, 3-base loop hairpin that is required for vRNAP recognition. We show that, contrary to certain theoretical predictions, hairpin extrusion can occur at physiological superhelical densities in a Mg2+-dependent manner. Specific sequences on the template strand are required for hairpin extrusion. These sequences define stable DNA hairpins that are relatively unreactive to single strand-specific probes. In addition, a specific stable hairpin-inducing sequence can regulate transcription in vivo. Thus, a DNA structure, in its natural environment, is involved in transcriptional regulation.
Ofatumumab: A Novel Anti-CD20 Monoclonal Antibody for the Treatment of Chronic Lymphocytic Leukemia (2012)

Chronic lymphocytic leukemia (CLL) is a heterogeneous disease arising from monoclonal proliferation of B lymphocytes. In the absence of poor risk features, CLL is characterized by an indolent clinical course but in 2012 it is still considered an incurable malignancy. Treatment of CLL is highly individualized and the majority of patients do not require treatment at the time of diagnosis. Therapy is, however, indicated for patients with advanced stage disease, high tumor burden, severe disease-related &amp;quot;B&amp;quot; symptoms, cytopenias, poor-risk cytogenetic features or repeated infections. Rituximab, a monoclonal antibody that targets the cell-surface molecule CD20 expressed on B-lymphocytes, is not widely used as a mono-therapy for CLL. Commonly employed first-line treatment regimens do include chlorambucil in conjunction with corticosteroids, fludarabine and cyclophosphamide or pentostatin and cyclophosphamide in conjunction with rituximab and, most recently, bendamustine and rituximab. While there have been substantial strides in finding aggressive combination chemo-immunotherapy regimens that have significant activity in the front-line setting, treatment options for patients with relapsed, poor risk, or refractory CLL are limited. Alemtuzumab, a monoclonal antibody targeting CD52 is increasingly becoming a part of the Oncologists’ armamentarium to combat for poor–risk CLL associated with adverse cytogenetic aberrations or recurrent or progressive CLL, but its use has been limited due to concerns for infectious complications. Ofatumumab (Arzerra™) is a novel, fully humanized anti-CD20 monoclonal antibody that binds to both small and large extracellular loops of CD20, has increased complement dependent cytotoxicity (CDC) and antibody dependent cytotoxicity (ADCC) compared to rituximab. Based on the results of a pivotal phase II study (Hx-CD20-406), which showed clinically meaningful and durable overall response rates, Ofatumumab was granted accelerated approval in October 2009 by U.S. Food and Drug administration for treatment of patients with fludarabine and alemtuzumab-refractory CLL. Several randomized trials are underway investigating its clinical benefit in CLL and other non-Hodgkin’s lymphomas.
Polymerized ragweed antigen E. I. Preparation and immunologic studies. (1973)

Glutaraldehyde treatment of partially purified ragweed AgE was done to provide cross-linked proteins of this material. The ragweed preparation contained a high concentration of antigen E. The glutaraldehyde treatment produced aggregates of ragweed antigen E that were fractionated through Sepharose 6B, 4B and Sephadex G-200 to prepare polymers of two molecular weight ranges, the first approximately 0.2 to 4 million and the second 4 to 20 million. These materials reacted completely with antibody against ragweed antigen E but required higher concentrations to neutralize antibody as the molecular weight of polymerized ragweed increased. The polymerized ragweed did not show antigenic deletion nor were new antigenic determinants definitively shown. The polymerized ragweed was at least as antigenic in animal studies as ragweed antigen E and the polymerized ragweed antigen with a molecular weight range of approximately 0.2 to 4 million showed evidence of possibly greater antigenicity than the monomeric ragweed antigen E.
Optimum Dosage of Quicklime to Livestock Wastes in Organic Fertilizer Process (2001)

The optimum dosage of quicklime in producing organic fertilizer using livestock wastes with a greater than 80% water content was analysed. After one day had elapsed to allow for the organic fertilizer to dry, the quicklime dosage and the composition of the organic fertilizer were analysed. Any from done to the organic fertilizer was also assessed. The amount of the quicklime required to stabilize livestock wastes was determined by water content of livestock wastes. For J farm(slurry style) of which livestock wastes have 94.6% of water concentration, less than 3% of total amount of livestock wastes, for H farm(scraper style) of which livestock wastes have 85% of water concentration, less then 4% of total livestock wastes and Y farm(traditional style) of which livestock wastes have 80% of water concentration, less then 5% of total livestock wastes. Generally, in order to pack the organic fertilizer, water containing quicklime-stabilized livestock wastes should be less than 35%. It takes 9 days to keep this water content for the wastes from H and Y farms(less than 85% in water content), and 12days for the wastes from J farm(94.6% in water content). According to the classification standard for compost constitution by Higgins, the crude fertilizers from all 3 farms had high grade K_2O and CaO, the middle grade T-N and middle or low grade P_2O_5. Stabilization by quicklime is known to inhibit bacterial decomposition of organic matter and the activity of pathogenic organisms. In this study, more than 99.99% of coliform group, fecal group and viable cell count were reduced. Our results indicate that livestock wastes of greater 80% water content could be used to produce organic fertilizer without the addition of a material for moisture control.
Path sharing and predicate evaluation for high-performance XML filtering (2003)

XML filtering systems aim to provide fast, on-the-fly matching of XML-encoded data to large numbers of query specifications containing constraints on both structure and content. It is now well accepted that approaches using event-based parsing and Finite State Machines (FSMs) can provide the basis for highly scalable structure-oriented XML filtering systems. The XFilter system [Altinel and Franklin 2000] was the first published FSM-based XML filtering approach. XFilter used a separate FSM per path query and a novel indexing mechanism to allow all of the FSMs to be executed simultaneously during the processing of a document. Building on the insights of the XFilter work, we describe a new method, called "YFilter" that combines all of the path queries into a single Nondeterministic Finite Automaton (NFA). YFilter exploits commonality among queries by merging common prefixes of the query paths such that they are processed at most once. The resulting shared processing provides tremendous improvements in structure matching performance but complicates the handling of value-based predicates.In this article, we first describe the XFilter and YFilter approaches and present results of a detailed performance comparison of structure matching for these algorithms as well as a hybrid approach. The results show that the path sharing employed by YFilter can provide order-of-magnitude performance benefits. We then propose two alternative techniques for extending YFilter's shared structure matching with support for value-based predicates, and compare the performance of these two techniques. The results of this latter study demonstrate some key differences between shared XML filtering and traditional database query processing. Finally, we describe how the YFilter approach is extended to handle more complicated queries containing nested path expressions.
Improved tracking capability and efficient radar allocation through the fusion of radar and infrared search-and-track observations (2000)

The benchmark problem addresses the efficient allocation of an agile-beam radar in the presence of highly maneuverable targets and radar ECM. The multisensor benchmark tracking solution is aided by the presence of a scanning infrared search-and-track (IRST) system. This paper presents methods for applying a tracker with interacting multiple- model (IMM) filtering and multiple-hypothesis tracking (MHT) data asso- ciation to this multiple-sensor tracking and resource allocation problem. It presents a hybrid multisensor tracking architecture in which an IMM- MHT tracker operating on IRST data provides the global IMM-MHT tracker with selected observations. Simulation results quantify the poten- tial improvement from the use of advanced tracking methods and IRST data to enhance agile-beam radar tracker capability. © 2000 Society of Photo-Optical Instrumentation Engineers. (S0091-3286(00)03205-0)
Nanowires for High-Efficiency, Low-Cost Solar Photovoltaics (2019)

Solar energy is abundant, clean, and renewable, making it an ideal energy source. Solar cells are a good option to harvest this energy. However, it is difficult to balance the cost and efficiency of traditional thin-film solar cells, whereas nanowires (NW) are far superior in making high-efficiency low-cost solar cells. Therefore, the NW solar cell has attracted great attention in recent years and is developing rapidly. Here, we review the great advantages, recent breakthroughs, novel designs, and remaining challenges of NW solar cells. Special attention is given to (but not limited to) the popular semiconductor NWs for solar cells, in particular, Si, GaAs(P), and InP.
Automation of Ocean Product Metrics (2008)

Abstract : A continual requirement exists to quickly and frequently evaluate the validity and accuracy of oceanographic data, models, algorithms, and products with comprehensible performance metrics that are meaningful and applicable to the supported mission. Results from these evaluations will help make performance improvements to the model and products, better assess the MetOc battle space environment, and provide decision makers with an improved perspective on the MetOc environment and the products.
Triaminocyclopropenium salts as ionic liquids (2011)

Salts of the charge-delocalised cations of the triaminocyclopropenium (tac) family bearing alkyl substituents have been prepared and shown to be air- and water-stable ionic liquids.