gebhart/patrepeval huggingface dataset:
Catalytic C−H Bond Amination from High-Spin Iron Imido Complexes (2011)

Dipyrromethene ligand scaffolds were synthesized bearing large aryl (2,4,6-Ph(3)C(6)H(2), abbreviated Ar) or alkyl ((t)Bu, adamantyl) flanking groups to afford three new disubstituted ligands ((R)L, 1,9-R(2)-5-mesityldipyrromethene, R=aryl, alkyl). While high-spin (S=2), four-coordinate iron complexes of the type ((R)L)FeCl(solv) were obtained with the alkyl-substituted ligand varieties (for R=(t)Bu, Ad and solv=THF, OEt(2)), use of the sterically encumbered aryl-substituted ligand precluded binding of solvent and cleanly afforded a high-spin (S=2), three-coordinate complex of the type ((Ar)L)FeCl. Reaction of ((Ad)L)FeCl(OEt(2)) with alkyl azides resulted in the catalytic amination of C-H bonds or olefin aziridination at room temperature. Using a 5% catalyst loading, 12 turnovers were obtained for the amination of toluene as a substrate, while greater than 85% of alkyl azide was converted to the corresponding aziridine employing styrene as a substrate. A primary kinetic isotope effect of 12.8(5) was obtained for the reaction of ((Ad)L)FeCl(OEt(2)) with adamantyl azide in an equimolar toluene/toluene-d(8) mixture, consistent with the amination proceeding through a hydrogen atom abstraction, radical rebound type mechanism. Reaction of p-(t)BuC(6)H(4)N(3) with ((Ar)L)FeCl permitted isolation of a high-spin (S=2) iron complex featuring a terminal imido ligand, ((Ar)L)FeCl(N(p-(t)BuC(6)H(4))), as determined by (1)H NMR, X-ray crystallography, and (57)Fe Mössbauer spectroscopy. The measured Fe-N(imide) bond distance (1.768(2) Å) is the longest reported for Fe(imido) complexes in any geometry or spin state, and the disruption of the bond metrics within the imido aryl substituent suggests delocalization of a radical throughout the aryl ring. Zero-field (57)Fe Mössbauer parameters obtained for ((Ar)L)FeCl(N(p-(t)BuC(6)H(4))) suggest a Fe(III) formulation and are nearly identical with those observed for a structurally similar, high-spin Fe(III) complex bearing the same dipyrromethene framework. Theoretical analyses of ((Ar)L)FeCl(N(p-(t)BuC(6)H(4))) suggest a formulation for this reactive species to be a high-spin Fe(III) center antiferromagnetically coupled to an imido-based radical (J = -673 cm(-1)). The terminal imido complex was effective for delivering the nitrene moiety to both C-H bond substrates (42% yield) as well as styrene (76% yield). Furthermore, a primary kinetic isotope effect of 24(3) was obtained for the reaction of ((Ar)L)FeCl(N(p-(t)BuC(6)H(4))) with an equimolar toluene/toluene-d(8) mixture, consistent with the values obtained in the catalytic reaction. This commonality suggests the isolated high-spin Fe(III) imido radical is a viable intermediate in the catalytic reaction pathway. Given the breadth of iron imido complexes spanning several oxidation states (Fe(II)-Fe(V)) and several spin states (S=0→(3)/(2)), we propose the unusual electronic structure of the described high-spin iron imido complexes contributes to the observed catalytic reactivity.
Genetic elimination of field-cage populations of Mediterranean fruit flies (2014)

The Mediterranean fruit fly (medfly, Ceratitis capitata Wiedemann) is a pest of over 300 fruits, vegetables and nuts. The sterile insect technique (SIT) is a control measure used to reduce the reproductive potential of populations through the mass release of sterilized male insects that mate with wild females. However, SIT flies can display poor field performance, due to the effects of mass-rearing and of the irradiation process used for sterilization. The development of female-lethal RIDL (release of insects carrying a dominant lethal) strains for medfly can overcome many of the problems of SIT associated with irradiation. Here, we present life-history characterizations for two medfly RIDL strains, OX3864A and OX3647Q. Our results show (i) full functionality of RIDL, (ii) equivalency of RIDL and wild-type strains for life-history characteristics, and (iii) a high level of sexual competitiveness against both wild-type and wild-derived males. We also present the first proof-of-principle experiment on the use of RIDL to eliminate medfly populations. Weekly releases of OX3864A males into stable populations of wild-type medfly caused a successive decline in numbers, leading to eradication. The results show that genetic control can provide an effective alternative to SIT for the control of pest insects.
Psoriasis and interleukin-1. A translation. (1993)

Dans le cadre de l'analyse des lesions dermatologiques, la recherche d'indicateurs physiologiques des maladies est courante. Le polymorphisme de l'antagoniste du recepteur de l'interleukine-1, semble etre un marqueur genetique du psoriasis.
Heterogeneity of Major Proteins in Lyme Disease Borreliae: A Molecular Analysis of North American and European Isolates (1985)

We examined 46 isolates of Borrelia burgdorferi, the etiologic agent of Lyme disease and related disorders, with polyacrylamide gel electrophoresis and monoclonal antibodies. Our attention was on the OspA proteins, which are major proteins of the spirochete. There were at least four discernible phenotypes of the OspA protein. While 25 North American isolates were, with one exception, homogeneous in the type of OspA protein that they produced, 21 European isolates were heterogeneous in the types of OspA proteins represented. Only three European strains resembled North American strains in their OspA phenotype. Application of a deoxyribonucleic acid probe for an ospA gene demonstrated that the arrangement of ospA-associated sequences in the DNA differed between isolates.
Structural and conformational basis of the resistance of .beta.-lactoglobulin to peptic and chymotryptic digestion (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural and conformational basis of the resistance of .beta.-lactoglobulin to peptic and chymotryptic digestionI. Mohan Reddy, Navin K. D. Kella, and John E. KinsellaCite this: J. Agric. Food Chem. 1988, 36, 4, 737–741Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/jf00082a015https://doi.org/10.1021/jf00082a015research-articleACS PublicationsRequest reuse permissionsArticle Views997Altmetric-Citations270LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Gustatory sensitivities in neurons of the hamster nucleus tractus solitarius. (1979)

Theodore Roosevelt introduces Judge Hotchkiss to Reverend Mortensen, who is the President of the Society of Inner Mission and Rescue Work as well as a member of the General Synod of the Lutheran Church of America. Roosevelt asks that Hotchkiss meet with Mortensen to find out how Mortensen may help their campaign.
Study Of Comparative Effects Of Oral Clonidine Vs Oral Diazepam Pre-Medication On The Extent And Duration Of Sensory Blockade In Patients Undergoing Vaginal Hysterectomy Under Spinal Anaesthesia (2009)

Clonidine stimulates alpha 2 adrenergic inhibitory neurons in medullary vasomotor centre which decreases sympathetic outflow. Decreased sympathetic nervous system activity is manifested as decreases in systemic blood pressure, heart rate and cardiac output. Our results show that there was significant difference in the time of onset of anaesthesia, which coincides with the study done by Herbhej singh, George, Y .Gaines and Paul .F.White, in which they concluded that oral Clonidine shortened the onset time of tetracaine’s sensory block & prolonged the duration of sensory & motor block. There are more studies, which also show that oral clonidine premedication prolong the sensory as well as motor blockade from Lignocaine & Tetracaine spinal anaesthesia. The antinociceptive effect produced by the orally administered 2adrenergic agonist is mainly caused by direct spinal activation due to spread of the drug via the systemic circulation into the spinal cord. Neuraxial Clonidine inhibits spinal substance P release and nociceptive neuron firing produced by noxious stimuli. Clonidine modifies function of K channels in the CNS causing cell membrane hyperpolarization which decreases anaesthetic requirements.
Stomatal Constraints May Affect Emission of Oxygenated Monoterpenoids from the Foliage of Pinus pinea (2002)

Dependence of monoterpenoid emission and fractional composition on stomatal conductance (G(V)) was studied in Mediterranean conifer Pinus pinea, which primarily emits limonene and trans-beta-ocimene but also large fractions of oxygenated monoterpenoids linalool and 1,8-cineole. Strong decreases in G(V) attributable to diurnal water stress were accompanied by a significant reduction in total monoterpenoid emission rate in midday. However, various monoterpenoids responded differently to the reduction in G(V), with the emission rates of limonene and trans-beta-ocimene being unaffected but those of linalool and 1,8-cineole closely following diurnal variability in G(V). A dynamic emission model indicated that stomatal sensitivity of emissions was associated with monoterpenoid Henry's law constant (H, gas/liquid phase partition coefficient). Monoterpenoids with a large H such as trans-beta-ocimene sustain higher intercellular partial pressure for a certain liquid phase concentration, and stomatal closure is balanced by a nearly immediate increase in monoterpene diffusion gradient from intercellular air-space to ambient air. The partial pressure rises also in compounds with a low H, but more than 1,000-fold higher liquid phase concentrations of linalool and 1,8-cineole are necessary to increase intercellular partial pressure high enough to balance stomatal closure. The system response is accordingly slower, and the emission rates may be transiently suppressed by low G(V). Simulations further suggested that linalool and 1,8-cineole synthesis rates also decreased with decreasing G(V), possibly as the result of selective inhibition of various monoterpene synthases by stomata. We conclude that physicochemical characteristics of volatiles not only affect total emission but also alter the fractional composition of emitted monoterpenoids.
ISOLATION OF MUMPS VIRUS FROM HUMAN BEINGS WITH INDUCED APPARENT OR INAPPARENT INFECTIONS (1948)

Exposure of fifteen children to mumps virus of fifth amniotic passage in chick embryos led to involvement of the salivary glands in six, orchitis in the absence of other manifestations of mumps in one, and to no signs of illness in eight. Attempts to isolate virus from the saliva of these individuals gave the following results: 1. All patients with involvement of the salivary glands excreted virus beginning on the 11th to 15th day after exposure, 2 to 6 days prior to onset of clinical signs of disease and extending up to the 4th day of illness. 2. The patient with primary orchitis without any recognized involvement of the salivary glands excreted virus for 2 days, beginning on the 15th day after exposure and 10 days prior to his illness. 3. Six of the eight children classified as having inapparent infections because of their serologic response in the absence of clinical signs of illness, began to excrete virus on the 15th to 16th day after exposure for from 1 to 9 or more days. The epidemiologic significance of these data is discussed.
Time Domain Fluorescent Diffuse Optical Tomography: analytical expressions (2005)

Light propagation in tissue is known to be favored in the Near Infrared spectral range. Capitalizing on this fact, new classes of molecular contrast agents are engineered to fluoresce in the Near Infrared. The potential of these new agents is vast as it allows tracking non-invasively and quantitatively specific molecular events in-vivo. However, to monitor the bio-distribution of such compounds in thick tissue proper physical models of light propagation are necessary. To recover 3D concentrations of the compound distribution, it is necessary to perform a model based inverse problem: Diffuse Optical Tomography. In this work, we focus on Fluorescent Diffuse Optical Tomography expressed within the normalized Born approach. More precisely, we investigate the performance of Fluorescent Diffuse Optical Tomography in the case of time resolved measurements. The different moments of the time point spread function were analytically derived to construct the forward model. The derivation was performed from the zero order moment to the second order moment. This new forward model approach was validated with simulations based on relevant configurations. Enhanced performance of Fluorescent Diffuse Optical Tomography was achieved using these new analytical solutions when compared to the current formulations.
Mouse actin messenger RNAs. Construction and characterization of a recombinant plasmid molecule containing a complementary DNA transcript of mouse alpha-actin mRNA. (1981)

An RNA fraction enriched in a-actin mRNA (isolated by sucrose-gradient fractionation of mouse skeletal muscle poly(A+) RNA) was used to synthesize doublestranded complementary DNA.Transcripts more than 900 nucleotides in length were inserted into the Pst I site of plasmid pBR 322 using poly(dC).poly(dG)tailing, and these molecules were used to transform Escherichia coli C 600. Transformant clones were hybridized in situ with complementary DNA transcribed from the actin-enriched muscle RNA, and those containing DNA sequences complementary to RNAs abundant in this population were selected.DNA was extracted from these clones, fixed to diazobenzyloxymethyl paper, and used to select the complementary RNA sequence.In this way, clone 91 was shown to contain an inserted sequence complementary to muscle and nonmuscle actin mRNAs.Comparison of the nucleotide sequence of part of the inserted DNA with the published amino acid sequences for mammalian actins showed that in four positions (278,286,296, and 298) the sequenced region encodes amino acids specific to a-actin.Sizing on agarose gels of the Pst I digest of this clone showed that it contains an inserted sequence of approximately 1350 base-pairs.This represents approximately 90% of the coding sequence for a-actin plus about 300 nucleotides of 3' noncoding sequence.Hybridization of the labeled plasmid DNA to RNA, separated on agarose gels and transferred to diazobenzyloxymethyl-paper, showed that mouse skeletal muscle and nonmuscle actin mRNAs have lengths of 1650 and 2100 nucleotides, respectively.A 200-nucleotide fragment of the plasmid, corresponding to the 3' noncoding region of the mRNA, hybridized specifically to the muscle actin mRNA.Proliferating cultures of a mouse myogenic cell line contained, in addition to the nonmuscle actin mRNAs, an actin mRNA slightly smaller than 1650 nucleotides which did not hybridize to the 200-nucleotide fragment of the plasmid.This
High Response Piezoelectric and Piezoresistive Materials for Fast, Low Voltage Switching: Simulation and Theory of Transduction Physics at the Nanometer‐Scale (2012)

Field effect transistors are reaching the limits imposed by the scaling of materials and the electrostatic gating physics underlying the device. In this Communication, a new type of switch based on different physics, which combines known piezoelectric and piezoresistive materials, is described and is shown by theory and simulation to achieve gigahertz digital switching at low voltage (0.1 V).
Synthesis of (+)-obafluorin, a .beta.-lactone antibiotic (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of (+)-obafluorin, a .beta.-lactone antibioticChristopher Lowe, Yunlong Pu, and John C. VederasCite this: J. Org. Chem. 1992, 57, 1, 10–11Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/jo00027a006https://doi.org/10.1021/jo00027a006research-articleACS PublicationsRequest reuse permissionsArticle Views477Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Evaluating Genome-Wide Association Study-Identified Breast Cancer Risk Variants in African-American Women (2013)

Genome-wide association studies (GWAS), conducted mostly in European or Asian descendants, have identified approximately 67 genetic susceptibility loci for breast cancer. Given the large differences in genetic architecture between the African-ancestry genome and genomes of Asians and Europeans, it is important to investigate these loci in African-ancestry populations. We evaluated index SNPs in all 67 breast cancer susceptibility loci identified to date in our study including up to 3,300 African-American women (1,231 cases and 2,069 controls), recruited in the Southern Community Cohort Study (SCCS) and the Nashville Breast Health Study (NBHS). Seven SNPs were statistically significant (P ≤ 0.05) with the risk of overall breast cancer in the same direction as previously reported: rs10069690 (5p15/TERT), rs999737 (14q24/RAD51L1), rs13387042 (2q35/TNP1), rs1219648 (10q26/FGFR2), rs8170 (19p13/BABAM1), rs17817449 (16q12/FTO), and rs13329835 (16q23/DYL2). A marginally significant association (P<0.10) was found for three additional SNPs: rs1045485 (2q33/CASP8), rs4849887 (2q14/INHBB), and rs4808801 (19p13/ELL). Three additional SNPs, including rs1011970 (9p21/CDKN2A/2B), rs941764 (14q32/CCDC88C), and rs17529111 (6q14/FAM46A), showed a significant association in analyses conducted by breast cancer subtype. The risk of breast cancer was elevated with an increasing number of risk variants, as measured by quintile of the genetic risk score, from 1.00 (reference), to 1.75 (1.30-2.37), 1.56 (1.15-2.11), 2.02 (1.50-2.74) and 2.63 (1.96-3.52), respectively, (P = 7.8 × 10(-10)). Results from this study highlight the need for large genetic studies in AAs to identify risk variants impacting this population.
RobustFill: Neural Program Learning under Noisy I/O (2017)

The problem of automatically generating a computer program from some specification has been studied since the early days of AI. Recently, two competing approaches for automatic program learning have received significant attention: (1) neural program synthesis, where a neural network is conditioned on input/output (I/O) examples and learns to generate a program, and (2) neural program induction, where a neural network generates new outputs directly using a latent program representation. Here, for the first time, we directly compare both approaches on a large-scale, real-world learning task. We additionally contrast to rule-based program synthesis, which uses hand-crafted semantics to guide the program generation. Our neural models use a modified attention RNN to allow encoding of variable-sized sets of I/O pairs. Our best synthesis model achieves 92% accuracy on a real-world test set, compared to the 34% accuracy of the previous best neural synthesis approach. The synthesis model also outperforms a comparable induction model on this task, but we more importantly demonstrate that the strength of each approach is highly dependent on the evaluation metric and end-user application. Finally, we show that we can train our neural models to remain very robust to the type of noise expected in real-world data (e.g., typos), while a highly-engineered rule-based system fails entirely.
Nocturnal periodic breathing in primary pulmonary hypertension (2002)

Cheyne-Stokes respiration is frequently observed in congestive heart failure. Among other factors, prolongation of circulation time, hypocapnia and hypoxia are thought to underlie this sleep-related breathing disorder. Primary pulmonary hypertension (PPH) is also characterized by reduced cardiac output and blood gas alterations. Therefore, the aim of the present study was to determine whether a nocturnal periodic breathing (PB) occurs in PPH. A total of 20 consecutive patients with PPH who had been admitted for pharmacological investigation of pulmonary vasoreactivity were investigated by lung function testing, right heart catheterization and full-night attended polysomnography. PB was detected in six patients (30%) (mean +/- SEM: apnoea/hypopnoea index 37 +/- 5 h(-1); arterial oxygen saturation was <90% during 56 +/- 6.5% of total sleep time). The patients with PB had more severe haemodynamic impairment than those without. They also had a more marked reduction in the pulmonary diffusion capacity and greater arterial hypoxia. PB was markedly improved or even eradicated by nasal oxygen during the night. Periodic breathing occurs in patients with advanced primary pulmonary hypertension and can be reversed by nocturnal nasal oxygen. The clinical and prognostic significance of periodic breathing in primary pulmonary hypertension needs to be determined by further studies.
Generalized Phase-Space Distribution Functions (1966)

A set of quasi-probability distribution functions which give the correct quantum mechanical marginal distributions of position and momentum is studied. The phase-space distribution does not have to be bilinear in the state function. The Wigner distribution is a special case. A general relationship between the phase-space distribution functions and the rule of associating classical quantities to quantum mechanical operators is derived. This allows the writing of correspondence rules at will,of which the ones presently known are particular cases. The dynamics and other properties of the generalized phase-space distribution are considered.
IntelŴVirtualization Technology for Directed I/O (2006)

Intel ® Virtualization Technology Δ for Directed I/O (VT-d) is the next important step toward comprehensive hardware support for the virtualization of Intel ® platforms. VT-d extends Intel's Virtualization Technology (VT) roadmap from existing support for IA-32 (VT-x) (1) and Itanium ® processor (VT-i) (2) virtualization to include new support for I/O-device virtualization. This paper surveys a variety of established and emerging techniques for I/O virtualization and outlines their associated problems and challenges. We then detail the architecture of VT-d and describe how it enables the industry to meet the future challenges of I/O virtualization.