gebhart/patrepeval huggingface dataset:
Capacitive Sensing of Glucose in Electrolytes Using Graphene Quantum Capacitance Varactors (2017)

A novel graphene-based variable capacitor (varactor) that senses glucose based on the quantum capacitance effect was successfully developed. The sensor utilizes a metal-oxide-graphene varactor device structure that is inherently compatible with passive wireless sensing, a key advantage for in vivo glucose sensing. The graphene varactors were functionalized with pyrene-1-boronic acid (PBA) by self-assembly driven by π-π interactions. Successful surface functionalization was confirmed by both Raman spectroscopy and capacitance-voltage characterization of the devices. Through glucose binding to the PBA, the glucose concentration in the buffer solutions modulates the level of electrostatic doping of the graphene surface to different degrees, which leads to capacitance changes and Dirac voltage shifts. These responses to the glucose concentration were shown to be reproducible and reversible over multiple measurement cycles, suggesting promise for eventual use in wireless glucose monitoring.
Design of VCO for 2.4GHz Wireless Applications Using Transmission Line Resonators (2007)

A voltage-controlled oscillator (VCO) employing on-chip coplanar waveguide (CPW) resonator is proposed for 2.4GHz wireless applications and comparative study between the proposed VCO and a conventional VCO which is composed of LC-tank resonator (LC-VCO), is carried out. By comparing the measured results on the fabricated chip on TSMC 0.35 mum BiCMOS technology, it has noted that the VCO employing on-chip CPW resonator is smaller in size by about 30% and frequency-tuning range is higher than LC-VCO. Phase noise is comparable but power consumption is deteriorated.
Degradable metallic biomaterials: Design and development of Fe–Mn alloys for stents (2009)

Designing materials having suitable mechanical properties and targeted degradation behavior is the key for the development of biodegradable materials for medical applications, including stents. A series of Fe-Mn alloys was developed with the objective to obtain mechanical properties similar to those of stainless steel 316L and degradation behavior more suited than pure iron. Four alloys with Mn content ranging between 20 and 35 wt % were compared in this study. Their microstructure, mechanical properties, magnetic properties as well as degradation behavior were carefully investigated. Results show that their microstructure is mainly composed of gamma phase with the appearance of epsilon phase in alloys having a lower Mn content. The yield strength and elongation of alloys was comprised between 234 MPa and 32% for Fe-35%Mn alloy to 421 MPa and 7.5% for the Fe-20%Mn alloy. All alloys show similar magnetic susceptibility ( approximately 1.8 x 10(-7) m(3)/kg) in the quenched condition. This magnetic susceptibility remains constant after plastic deformation for all the tested alloys except for the Fe-20%Mn alloy. The corrosion rate was higher than pure iron. Among the alloys studied in this work, the Fe-35%Mn alloy shows mechanical properties and degradation behavior closely approaching those required for biodegradable stents application.
Formation and Growth of Semiconductor PbTe Nanocrystals in a Borosilicate Glass Matrix (1997)

Pb- and Te-doped borosilicate glasses are transformed by appropriate heat treatment into a composite material consisting of a vitreous matrix in which semiconductor PbTe nanocrystals are embedded. This composite exhibits interesting non-linear optical properties in the infrared region, in the range 10–20 000 Å. The shape and size distribution of the nanocrystals and the kinetics of their growth were studied by small-angle X-ray scattering (SAXS) during in situ isothermal treatment at 923 K. The experimental results indicate that nanocrystals are nearly spherical and have an average radius increasing from 16 to 33 Å after 2 h at 923 K, the relative size dispersion being time-invariant and approximately equal to 8%. This investigation demonstrates that the kinetics of nanocrystal growth are governed by the classic mechanism of atomic diffusion. The radius of nanocrystals, deduced by applying the simple Efros &amp; Efros [ Sov. Phys. Semicond. (1982), 16 , 772–775] model using the energy values corresponding to the exciton peaks of optical absorption spectra, does not agree with the average radius determined by SAXS.
Microfluidic Printheads for Multimaterial 3D Printing of Viscoelastic Inks (2015)

Multimaterial 3D printing using microfluidic printheads specifically designed for seamless switching between two visco-elastic materials "on-the-fly" during fabrication is demonstrated. This approach opens new avenues for the digital assembly of functional matter with controlled compositional and property gradients at the microscale.
Fresh small-fragment osteochondral allografts. Long-term follow-up study on first 100 cases. (1985)

Of 100 patients receiving fresh osteochondral fragment allografts, 95 had replacement of the weight-bearing portion of the knee. The allografts excised under sterile conditions were stored in Ringer's lactate at 4 degrees and transplanted into recipients within 24 hours. The average follow-up time was 3.8 years. One-half of the patients had allografts because of traumatic injury, and the best results (75% success) were obtained in this group of patients. The overall results were not encouraging for patients with osteoarthritis or spontaneous osteonecrosis.
PHARMACOLOGICAL REGULATION OF CALMODULIN* (1980)

A number of psychotropic drugs, particularly the phenothiazines and related antipsychotic compounds, inhibit a variety of calmodulin-dependent enzymes. The mechanism by which these compounds inhibit the activity of calmodulin is through a selective calcium-dependent binding to this protein. With the notable exception of certain stereoisomers, compounds that are clinically effective antipsychotic agents showed the greatest degree of binding to calmodulin. Other classes of pharmacological agents, including aminergic agonists and antagonists, and nonspecific central nervous system depressants and stimulants, showed little or no binding to calmodulin. In fact, the specificity with which antipsychotic drugs bind to calmodulin suggests the possibility of screening for new and clinically more effective antipsychotic agents based on their selective binding to calmodulin. Certain neuropeptides that produce behavioral effects in animals also were found to inhibit the activity of calmodulin, suggesting that there may be endogenous psychotogens or antipsychotic peptides that interact with calmodulin. Although under ordinary conditions the binding of antipsychotics to calmodulin is reversible, the binding of phenothiazine antipsychotics to calmodulin can be made irreversible either photochemically by ultraviolet irradiation, or enzymatically by a hydrogen peroxide-peroxidase system. Such a labeling technique should prove to be a useful tool to study the localization and turnover of calmodulin. These results indicate that several of the diverse biochemical actions of antipsychotic agents can be explained by a common mechanism, namely, by their binding to and inhibition of calmodulin, and raise the possibility that calmodulin may serve as one of the cellular receptors for certain antipsychotic compounds. However, further studies must be completed before we can state with any degree of certainty that these in vitro biochemical findings can explain the pharmacological and clinical actions of the antipsychotics.
Reflective waveguide array demultiplexer in LiNbO/sub 3/ (1996)

Wavelength demultiplexer fabricated on electrooptic LiNbO/sub 3/ is demonstrated. Reflection structure was employed to halve the device length. The full width at half maximum of the transmission peak was around 1 nm. The crosstalk was -12 to -25 dB. Polarization independence was attained using a reflective quarter-wave plate.
Elevated cytokine concentrations in the nasopharyngeal and tracheal secretions of children with respiratory syncytial virus disease (1999)

The presence of cytokines in NW and TA samples of children with RSV infection suggests that they have a role in mediating the respiratory tract inflammation induced by RSV. These observations could have implications for designing new therapeutic strategies directed at immunomodulation of RSV disease.
Anthrax toxin fusion proteins for intracellular delivery of macromolecules (1999)

The dominant role played by the anthrax toxin in Bacillus anthracis pathogenesis shows that the toxin has evolved to be an efficient system for delivering its two catalytic protein components, oedema factor and lethal factor (LF), into the cytosol of host cells. This system involves binding of the protective antigen (PA) toxin component to a ubiquitous (and still unidentified) receptor, proteolytic activation at the cell surface, internalization by endocytosis and translocation through an early endosome membrane to the cytosol (Leppla 1995). We and colleagues showed that the system can be exploited to deliver heterologous polypeptides to the cytosol (Arora et al. 1992; Milne et al. 1995). This work used the catalytic domains of other toxins which are normally translocated across membranes (Arora & Leppla 1994). Immunity to intracellular pathogens depends on the cytosolic processing of antigens to produce peptides that are presented on the cell surface bound to MHC Class I molecules. The anthrax toxin delivery system provides a way to mimic this process. We made a fusion protein containing the (non-catalytic) amino terminal domain of LF and the gp120 envelope glycoprotein of HIV-1. Administration of this recombinant protein along with PA to antigen-presenting cells sensitized them to cytolysis by cytotoxic T-cells specific to gp120 peptides (Goletz et al. 1997). Further exploitation of the anthrax toxin system as a cell-targeting reagent would be facilitated by achieving cell type specificity. The recent determination of the PA structure (Petosa et al. 1997) allows rational engineering to modify or replace the receptor-binding domain with specific ligand structures. A model system was produced by fusing a c-Myc peptide to the carboxyl terminus of PA so as to target hybridoma cells expressing cell surface antibodies to this peptide. Killing of the hybridoma cells was shown to be specific by competition with the peptide and with non-toxic mutants of PA (Varughese et al. 1998).
The Genetics of alcoholism (1995)

PART I: Genetic Epidemiology 1: V.M. Hesselbrook: The Genetic Epidemiology of Alcoholism 2: M.N. Hesselbrook: Genetic Determinants of Alcoholic Subtypes 3: R.J. Cadoret: Familial Transmission of Psychiatric Disorders Associated with Alcoholism 4: A.C. Heath: Genetic Influences on Drinking Behavior in Humans 5: J.R. Wilson and E. Laffan: Alcohol Metabolism, Sensitivity and Tolerance: Testing for Genetic Influences PART II: Laboratory Studies in Animals and Humans of Genetic Influences in Alcoholism 6: R.A. Deitrich and R.C. Baker: Genetic Influences on Alcohol Metabolism and Sensitivity to Alcohol in Animals 7: L. Lumeng et al.: Genetic Influences on Alcohol Preference in Rodents 8: D.W. Crabb et al.: Genetic Factors that Reduce Risk for Developing Alcoholism 9: A.E. Kosobud and J.C. Crabbe: Genetic Influences on the Development of Alcohol Physical Dependence and Withdrawal PART III: Strategies for Genetic Research in Alcoholism 10: I. Diamond and A. Gordon: Biochemical Markers for Genetic Alcoholism 11: H. Begleiter and B. Porjesz: Phenotypic Markers for the Development of Alcoholism 12: R. Tarter, H.E. Moss and M.M. Vanyukov: Behavior Genetics and the Etiology of Alcoholism 13: G.E. McClearn and R. Plonim: Strategies for the Search for Genetic Influences in Alcohol-Related Phenotypes 14: A.F. Wilson and R.C. Elston: Linkage Analysis in the Study of the Genetics of Alcoholsim
Enzyme‐modified proteins from corn gluten meal: Preparation and functional properties (1992)

Functional properties of proteins in corn gluten meal (CGM) can be improved by enzyme hydrolysis combined with membrane technology. CGM was treated with a protease (Alcalase), resulting in 30–50% of the proteins being converted to soluble peptides. Conversions were higher when CGM was pretreated with cysteine or sulfite. Solubility and clarity of the enzyme‐modified proteins were better at higher degrees of hydrolysis (DH). Higher DH increased initial foam volume but decreased foam stability. Membrane filtration of the hydrolyzed CGM reaction mixture resulted in two peptide fractions, as determined by size‐exclusion high‐performance liquid chromatography. Protein solubility of the membrane‐permeable fraction was 90–99% compared with 8% for unmodified proteins. Larger‐pore membranes improved foaming but decreased solubility and clarity. Moisture sorption at a water activity of 0.97 was 3.75 g water per gram of enzyme‐modified/ultrafiltered CGM, compared with 0.2 g/g for the unmodified CGM.
Gene Transfer of Stromal Cell–Derived Factor-1α Enhances Ischemic Vasculogenesis and Angiogenesis via Vascular Endothelial Growth Factor/Endothelial Nitric Oxide Synthase–Related Pathway (2004)

SDF-1alpha gene transfer enhanced ischemia-induced vasculogenesis and angiogenesis in vivo through a VEGF/eNOS-related pathway. This strategy might become a novel chemokine therapy for next generation therapeutic neovascularization.
Hypomethylation Promotes Autonomous Endosperm Development and Rescues Postfertilization Lethality in fie Mutants (2000)

Rinke Vinkenoog, Melissa Spielman, Sally Adams, Robert L. Fischer, Hugh G. Dickinson, Rod J. Scott, Hypomethylation Promotes Autonomous Endosperm Development and Rescues Postfertilization Lethality in fie Mutants, The Plant Cell, Vol. 12, No. 11 (Nov., 2000), pp. 2271-2282
Antitumor bisdioxopiperazines inhibit yeast DNAtopoisomerase II by trapping the enzyme in the form of a closed proteinclamp. (1994)

The mechanism of inhibition of eukaryotic DNA topoisomerase II [DNA topoisomerase (ATP-hydrolyzing), EC 5.99.1.3] by a member of the bisdioxopiperazine family of anticancer drugs, ICRF-193, was investigated by using purified yeast DNA topoisomerase II. In the absence of ATP, ICRF-193 has little effect on the binding of the enzyme to various forms of DNA. In the presence of ATP, the drug converts the enzyme to a form incapable of binding circular DNA. Incubation of a preformed circular DNA-enzyme complex with ICRF-193 and ATP converts the complex to a form stable in molar concentrations of salt. These results can be interpreted in terms of the ATP-modulated protein-clamp model of type II DNA topoisomerases [Roca, J. & Wang, J. C. (1992) Cell 71, 833-840]; ICRF-193 can bind to the closed-clamp form of the enzyme and prevents its conversion to the open-clamp form. This interpretation is further supported by the finding that whereas both ATP and the drug are needed to form the salt-stable circular DNA-enzyme complex, ATP is not needed for maintaining this complex; furthermore, a signature of the closed-clamp form of the enzyme, Staphylococcus aureus strain V8 endoproteinase cleavage site at Glu-680, is observed if the enzyme is incubated with both ATP and ICRF-193. Inhibition of interconversion between the open- and closed-clamp forms of type II DNA topoisomerases offers a new mechanism in the selection and design of therapeutics targeting this class of enzymes.
Antiphosphatidylethanolamine antibodies as the only antiphospholipid antibodies detected by ELISA. II. Kininogen reactivity. (1996)

In the 18 patients, kininogens and/or HMWK binding proteins served as a "cofactor" significantly more often for aPE IgG than for aPE IgM (p = 0.007). Kininogen dependent aPE Ig were observed more often in patients with LR with or without TEE (6/8) than in those with SLE or primary APS (0/4) but this difference merely tended to significance (p = 0.06). In 2 patients, one with TEE, the other with primary APS, the IgM aPE was dependent on a serum "cofactor" that was not kininogen.
Non-ablative fractional resurfacing of surgical and post-traumatic scars. (2009)

These data illustrate the safety and efficacy of the 1540 nm erbium:glass fractional laser in the treatment of surgical and post-traumatic scars. Practitioners can vary energy and microbeam density in order to tailor the treatment to reflect the individual scar characteristics.
Classless Inter-domain Routing (CIDR): The Internet Address Assignment and Aggregation Plan (2006)

This memo discusses the strategy for address assignment of the
existing 32-bit IPv4 address space with a view toward conserving the
address space and limiting the growth rate of global routing state.
This document obsoletes the original Classless Inter-domain Routing
(CIDR) spec in RFC 1519, with changes made both to clarify the
concepts it introduced and, after more than twelve years, to update
the Internet community on the results of deploying the technology
described. This document specifies an Internet Best Current Practices
for the Internet Community, and requests discussion and suggestions
for improvements.
Cancer‐associated changes in glycosylation of fibronectin (1992)

The extracellular matrix adhesion molecule fibronectin exhibits different isoforms derived by alternative splicing as well as recently demonstrated variation in O-glycosylation. Although fibronectin is widely distributed in normal tissues, the individual isoforms have been found to show restricted tissue distribution and association with malignancies. The monoclonal antibody FDC-6 defines a cancer-associated de novo glycosylation of a specific threonine residue in the C-terminal region of the fibronectin molecule termed oncofetal fibronectin. Here we report an immunohistological study of oral squamous cell carcinomas (n = 33), premalignant lesions (n = 15), and normal oral mucosa (n = 10) using the FDC-6 antibody. A selective expression of the oncofetal fibronectin epitope was demonstrated in close relation to the invading carcinoma, whereas no staining was observed in premalignant lesions without epithelial dysplasia, or in normal epithelium. Furthermore, we attempted to identify additional carbohydrate-related epitopes distinguishing fibronectin of human hepatoma cell line HUH-7 from plasma fibronectin. No novel epitopes were identified, as all generated monoclonal antibodies lacking reactivity with plasma fibronectin showed the same specificity as FDC-6. Previous studies have indicated that the de novo glycosylation is induced by a novel transferase activity only found in fetal and carcinoma cell lines, placenta and hepatoma tissues. Here we provide further evidence that a purified UDP-GalNAc:peptide N-acetylgalactosaminyltransferase from normal bovine thymus and human placentae is incapable of utilizing the hexapeptide VTHPGY as a substrate. The results demonstrate that oncofetal fibronectin is highly associated with malignancy, and appears to be induced by expression of a unique glycosyltransferase or modification of the specificity of the normally expressed transferase.
Band-Selective Measurements of Electron Dynamics inVO2Using Femtosecond Near-Edge X-Ray Absorption (2005)

We report on the first demonstration of femtosecond x-ray absorption spectroscopy, made uniquely possible by the use of broadly tunable bending-magnet radiation from "laser-sliced" electron bunches within a synchrotron storage ring. We measure the femtosecond electronic rearrangements that occur during the photoinduced insulator-metal phase transition in VO2. Symmetry- and element-specific x-ray absorption from V2p and O1s core levels (near 500 eV) separately measures the filling dynamics of differently hybridized V3d-O2p electronic bands near the Fermi level.
Design and Pharmacological Activity of Phosphinic Acid Based NAALADase Inhibitors (2001)

A novel series of phosphinic acid based inhibitors of the neuropeptidase NAALADase are described in this work. This series of compounds is the most potent series of inhibitors of the enzyme described to date. In addition, we have shown that these compounds are protective in animal models of neurodegeneration. Compound 34 significantly prevented neurodegeneration in a middle cerebral artery occlusion model of cerebral ischemia. In addition, in the chronic constrictive model of neuropathic pain, compound 34 significantly attenuated the hypersensitivity observed with saline-treated animals. These data suggest that NAALADase inhibition may provide a new approach for the treatment of both neurodegenerative disorders and peripheral neuropathies.
Molecular Evidence of Endogenous Reactivation ofMycobacterium tuberculosisafter 33 Years of Latent Infection (2002)

Since Robert Koch described the cause of tuberculosis in 1882, the natural history of the disease after primary infection has been subject to debate. Only approximately 10% of infected individuals develop active disease, which may appear years to decades after infection. Late onset has been attributed to the endogenous reactivation of dormant bacteria. However, this has not been documented by molecular means for latencies of more than a few years. In Denmark, we have recently recultured 205 freeze-dried Mycobacterium tuberculosis strains obtained from 1961 through 1967. These "historical" strains are analyzed by DNA restriction fragment-length polymorphism testing, and their DNA patterns are compared with those of 4008 recently obtained clinical specimens. This has, surprisingly, yielded molecular evidence of M. tuberculosis reactivation after 33 years of latent infection. A father and son who developed tuberculosis in 1961 and in 1994, respectively, were the only patients infected with strains that share an identical DNA pattern.
Multiple quantum filters for elucidating NMR coupling networks (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple quantum filters for elucidating NMR coupling networksU. Piantini, O. W. Sorensen, and Richard R. ErnstCite this: J. Am. Chem. Soc. 1982, 104, 24, 6800–6801Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/ja00388a062https://doi.org/10.1021/ja00388a062research-articleACS PublicationsRequest reuse permissionsArticle Views1282Altmetric-Citations1508LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts