gebhart/patrepeval huggingface dataset:
INFECTIOUS DISEASES IN CRITICAL CARE MEDICINE (1998)

GENERAL CONCEPTS. Infection Control Considerations: Isolation/Precaution. Fever in the Critical Care Unit. Sepsis and Mimics of Sepsis. CLINICAL SYNDROMES. Meningitis and Fever and the Mimics. Encephalitis and its Mimics. PostneurosurgicalInfections. Severe Community-Acquired Pneumonia. Nosocomial Pneumonia. Lung Abscess/Pleural Empyema. Acute Myocarditis and Acute Pericarditis. Infective Endocarditis and Mimics of Endocarditis.Central Intravascular Line Infections. Intra-Abdominal Surgical Infections and Mimics of Intra-Abdominal Infections. C. difficile Diarrhea/Colitis. Urosepsis. Severe Skin and Soft Tissue Infections. SPECIAL PROBLEM AREAS. Fever and Rash. Infections inReturning Travelers. Infections in AIDS Patients. Infections in Cirrhosis. Infections in Uremic Patients. Infections in Asplenics. Infected Multiple-System Trauma Patient. Bioterrorism. THERAPEUTIC CONSIDERATIONS. Antibiotic Selection in the IntensiveCare Unit. Antibiotic Resistance in the Intensive Care Unit. Antibiotic Dosing in Hepatic/Renal Insufficiency. Antibiotic Therapy in Penicillin-Allergic Patients. Antibiotic Side Effects
Full duplex backscatter (2013)

This paper asks the following question: could we transform the radios found in our personal gadgets into powerful multipurpose scanning devices that can detect and locate tumors, guns, buried human bodies, a la the Star Trek Tricoder? Our key insight is that if radios could measure the backscatter of their own transmissions (i.e. reflections from the environment of their transmissions), then Tricorder-style powerful object detection and localization algorithms could be realized. In this paper we focus specifically on backscatter measurement, we describe novel circuits and algorithms that can be added to existing radios to enable them to accurately and concurrently receive and disentangle their own transmissions' reflections and infer its properties.
Discrete alterations of the insulin-like growth factor I molecule which alter its affinity for insulin-like growth factor-binding proteins result in changes in bioactivity. (1990)

Insulin-like growth factor (IGF)-binding proteins (BPs) bind IGF-I and IGF-II with high affinity. They are present in extracellular fluids and modulate the interactions of their ligands with the type 1 IGF cell surface receptor. These studies utilized IGF-I analogs that have reduced binding affinity for either the type 1 IGF receptor or binding proteins to study the ligand specificity of IGF-BP-1 and the role of IGF-BP-1 in modulating the biological activity of IGF-I. The data indicate that the regions of IGF-I which are responsible for binding to IGF-BP-1 and to human serum-binding proteins are distinct but overlapping and are clearly distinct from the type I receptor binding sites. In the absence of exogenously added IGF-BP-1, the analogs with reduced affinity for IGF-BP-1 are more potent than IGF-I in stimulating DNA synthesis by porcine aortic smooth muscle cells. In contrast, when cells are concomitantly exposed to IGF-BP-1, two of the analogs with reduced affinity for binding protein give only 40-65% of the maximal IGF-I response. [Leu24, 1-62]IGF-I, which has a 100-fold reduced affinity for the type 1 IGF receptor, gave a value that was 62% of the maximal IGF-BP-1 potentiated response. A second biological response, that of stimulating binding protein secretion by IGF-I, was also examined. [Leu24, 1-62]IGF-I is more potent than IGF-I whereas the activity of the analogs with lower affinity for IGF-BP-1 is significantly reduced. Thus, the ability to activate DNA synthesis and binding protein secretion maximally in the presence of IGF-BP-1 is dependent on the affinity of IGFs for both type 1 receptors and binding proteins.
A Custom Designed Chip to Control an Implantable Stimulator and Telemetry System for Control of Paralyzed Muscles (1999)

A custom designed chip has been developed for the control of paralyzed muscles. The system is capable of fulfilling the stimulus and telemetry needs of advanced functional neuromuscular stimulation (FNS) applications requiring multiple channels of stimulation and multiple channels for sensor or biopotential sensing. An inductive radiofrequency link provides power to the implant device as well as 2 way transcutaneous communication. An application specific integrated circuit (ASIC) decodes the commands and provides functional control within the implant, and modular circuitry provides specific implant functions. The ASIC chip provides up to 32 independent channels of stimulation with independent control of stimulus pulse duration, pulse amplitude, interphase delay, recharge phase duration, and pulse interval. It can also control up to 8 independent back telemetry analog channels with independent control of sampling rate and pulse powering parameters (amplitude and duration). The mixed analog digital chip has been fabricated in 1.2 microm n-well CMOS technology.
Endovascular treatment of extracranial vertebral artery stenosis (2012)

Percutaneous angioplasty and stenting for the treatment of extracranial vertebral artery (VA) stenosis seems a safe, effective and useful technique for resolving symptoms and improving blood flow to the posterior circulation, with a low complication rate and good long-term results. In patients with severe tortuosity of the vessel, stent placement is a real challenge. The new coronary balloon-expandable stents may be preferred. A large variability of restenosis rates has been reported. Drug-eluting stents may be the solution. After a comprehensive review of the literature, it can be concluded that percutaneous angioplasty and stenting of extracranial VA stenosis is technically feasible, but there is insufficient evidence from randomized trials to demonstrate that endovascular management is superior to best medical management.
AGM-1470 Inhibits the Growth of Human Glioblastoma Cells in Vitro and in Vivo (1994)

GLIOBLASTOMA IS THE most malignant primary brain tumor. Inhibition of angiogenesis is one potential strategy for treating this fatal hypervascular tumor. AGM-1470 (also called TNP-470), a novel, potent, fungus-derived inhibitor of angiogenesis, was tested on the growth of human glioblastoma cells in culture and on the growth of the tumor in nude mice. In nude mice with subrenally implanted U-87 MG glioblastomas, AGM-1470 significantly inhibited tumor growth (P < 0.01), and in nude mice with intracranial U-87 MG glioblastomas, AGM-1470 prolonged survival. In addition to its expected action as an angiogenesis inhibitor, AGM-1470 also directly inhibited U-87 MG cells in culture at concentrations similar to those that inhibited endothelial cells. The combined inhibition of glioblastoma cell mitosis and of glioblastoma-induced neovascularization suggests that AGM-1470 should be considered for further investigation in the treatment of this fatal tumor.
Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice (1997)

To compare the function of the tumor necrosis factor (TNF) and lymphotoxin (LT)alpha/beta systems in the mature immune system, these two pathways were blocked with soluble receptor-immunoglobulin (R-Ig) fusion proteins in normal adult mice. Inhibition of LT alpha/beta signaling using LT betaR-Ig or a blocking monoclonal antibody against murine LT beta had profound effects. The spleen lacked discrete B cell follicles and the marginal zone was altered. Less marked changes were detected in lymph nodes. LT alpha/beta inhibition also prevented germinal center formation in the spleen and impaired Ig production in response to sheep red blood cells (SRBC) immunization. These results show that the LT alpha/beta system is required for the maintenance of splenic architecture and normal immune responses, and not simply for the development of peripheral immune organs during ontogeny. In contrast, inhibition of the TNF/LT alpha pathway with TNF-R55-Ig did not affect the splenic architecture or the anti-SRBC response. Splenic defects and impaired antibody responses are seen in TNF-deficient mice, suggesting that TNF is important during development. Therefore relative to TNF, the LT system has the dominant influence on splenic organization and anti-SRBC Ig formation in the adult mouse.
Exploiting Topographical Texture To Impart Icephobicity (2010)

Appropriately structured topographical features that are found in nature (e.g,, the lotus leaf) or that are produced synthetically (e.g., via lithography) can impart superhydrophobic properties to surfaces. Water beads up and readily rolls off of such surfaces, making them self-cleaning. Within the past few years, scientists and engineers have begun exploring the utility of these surfaces in mitigating the icing problem prevalent in the operation of critical infrastructure such as airplanes, ships, power lines, and telecommunications equipment. An article in this issue advances our fundamental knowledge in this area by examining the dynamic impact of water droplets on both smooth and topographically structured supercooled substrates. The results illustrate that, under at least some environmental conditions, superhydrophobic surfaces can minimize or even eliminate ice formation by repelling impinging water drops before they can freeze. Subsequent research will build on these results, possibly leading to the fabrication of commercially viable and durable icephobic surfaces that mitigate the icing problem under all environmental conditions.
Impact of Backreflections on Single-fiber Bidirectional Wavelength-Division-Multiplexing Passive Optical Networks (WDM-PONs) (2013)

With increased demand for bandwidth-hungry applications such as video-on-demand, wavelength-division-multiplexing passive optical network (WDM-PON) has become a strong contender in overcoming the last mile bottle neck. However, the wide-scale deployment of WDM-PONs has been delayed mainly due to the high cost of wavelength-specific optical components. To realize cost-effective WDM-PONs, various wavelength-independent, so called colorless architectures, have been developed so that all the subscribers can have identical optical network units (ONUs). In such WDM-PONs, however, single-fiber bidirectional transmission results in degradation of system performance caused by interference between the signals and backreflections. This thesis investigates the impact of backreflections on single-fiber bidirectional WDM-PONs. A WDM-PON with various optical line terminals (OLTs) and colorless ONU configurations is presented. The dependence of the power penalty, caused by backreflections, on a variety of parameters is investigated. This includes parameters such as the source linewidths, receiver bandwidth, transmission line loss (TLL), ONU gain, chirp effect at the ONU and optical return loss (ORL), in various WDM-PON configurations. The WDM-PON with continuous wave (CW) seed light and remodulation schemes are both presented and studied experimentally. The impacts of the backreflections on the single-fiber bidirectional WDM-PON with various OLT and ONU configurations are compared and analyzed accordingly.
Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission (2014)

Significance A growing body of evidence has determined that somatic mutations in acute myeloid leukemia (AML) accumulate in self-renewing hematopoietic stem cells (HSCs). Thus, at the time of diagnosis, AML patients harbor preleukemic HSCs containing some, but not all, of the mutations in the downstream leukemia. Despite these findings, common patterns of preleukemic clonal evolution have not been determined, nor has the response of preleukemic HSCs to standard therapy been identified. This report addresses both of these questions determining that there are common patterns of preleukemic clonal evolution in AML, and that these preleukemic HSCs often survive standard induction chemotherapy. This study is of interest to the AML field, and broadly in cancer genomics as the principle that stem cells acquire initial cancer-initiating mutations is likely to extend beyond AML.
HIV Receptors and Cellular Tropism (2002)

Viruses use specific cell surface receptors to bind to and subsequently gain entry into their host cells. Some retroviruses such as HIV-1 and HIV-2 utilize one receptor for high-affinity binding (CD4), and a separate coreceptor to mediate fusion of the viral envelope with the cell membrane (CCR5 or CXCR4). The identification of these receptors explains the cellular tropism of HIV, and hence its pathogenesis leading to immune deficiency (T-helper cell depletion), the wasting syndrome (macrophage infection), and dementia (microglia infection). HIV can infect cells by membrane fusion at the cell surface and by receptor-mediated endocytosis. Knowledge of the HIV receptors has led to practical developments such as inhibitory drugs, reasons for genetic resistance to infection, and should inform the judicious choice of candidate vaccines.
Anti‐Ro (SS‐A) and Anti‐La (SS‐B) in patients with Sjögren's syndrome (1986)

Clinical, serologic, and genetic findings in Sjögren's syndrome patients were correlated with quantitative determinations for antibody against Ro (SS-A), La (SS-B), and nRNP (Sm) using newly developed, sensitive solid-phase assays. In 86 Sjögren's syndrome patient sera, more than 96% had anti-Ro (SS-A), and 87% had anti-La (SS-B), spanning a 4.8 log10 range of autoantibody concentration, whereas only 95% of the patients had anti-nRNP (Sm). Low levels of anti-Ro (SS-A) and anti-La (SS-B) were found in 10% and 12.5%, respectively, of the 40 normal control sera. In Sjögren's syndrome patients, the level of anti-Ro (SS-A) correlated strongly with that of anti-La (SS-B) (r = 0.80; P less than 0.0001) but not with the level of anti-nRNP (Sm). We found much higher levels of anti-Ro (SS-A) and anti-La (SS-B) in patients with purpura, leukopenia, lymphopenia, and increased polyclonal gamma globulins than in those without these conditions (between 4.3-fold and 17-fold higher; P less than 0.001 to P less than 0.05). Anti-Ro (SS-A) and anti-La (SS-B) levels correlated with the rheumatoid factor titer and with the concentrations of total globulin, IgG, and IgA, but not with the IgM concentration. The association of rheumatoid factor titer with levels of anti-Ro (SS-A) and anti-La (SS-B) occurred only in patients with primary Sjögren's syndrome. Antinuclear antibody titers correlated with levels of anti-Ro (SS-A) and anti-nRNP (Sm). HLA-DR3-positive patients had higher levels of anti-Ro (SS-A) and anti-La (SS-B).
Electrophysiological Properties of Mutant Na v 1.7 Sodium Channels in a Painful Inherited Neuropathy (2004)

Although the physiological basis of erythermalgia, an autosomal dominant painful neuropathy characterized by redness of the skin and intermittent burning sensation of extremities, is not known, two mutations of Na(v)1.7, a sodium channel that produces a tetrodotoxin-sensitive, fast-inactivating current that is preferentially expressed in dorsal root ganglia (DRG) and sympathetic ganglia neurons, have recently been identified in patients with primary erythermalgia. Na(v)1.7 is preferentially expressed in small-diameter DRG neurons, most of which are nociceptors, and is characterized by slow recovery from inactivation and by slow closed-state inactivation that results in relatively large responses to small, subthreshold depolarizations. Here we show that these mutations in Na(v)1.7 produce a hyperpolarizing shift in activation and slow deactivation. We also show that these mutations cause an increase in amplitude of the current produced by Na(v)1.7 in response to slow, small depolarizations. These observations provide the first demonstration of altered sodium channel function associated with an inherited painful neuropathy and suggest that these physiological changes, which confer hyperexcitability on peripheral sensory and sympathetic neurons, contribute to symptom production in hereditary erythermalgia.
Origin of Seeded Endothelial Cells (1989)

This study proposes to evaluate the effectiveness of porcine endothelial cell seeding on the patency rate and the cellular lining of healed grafts. Nonseeded grafts were implanted in a series of 8 dogs while porcine endothelial cell-seeded grafts were used in 15 animals. Aspirin (325 mg) was given daily to all animals. The thirty-two-day patency rate was 25% (2/8) versus 67% (10/15) respectively for the control and seeded grafts (p &lt; .01). All patent grafts were lined with an endothelial surface. Cultures of the thirty-two-day old seeded grafts grew a combination of canine and porcine cells at a ratio of 5/1. The authors conclude that allograft cell seeding increases the patency rate of vena cava grafts and may stimulate growth of host canine cells. No clinical adverse reactions were noted with allograft cell seeding in the present study.
Reciprocation, square root, inverse square root, and some elementary functions using small multipliers (2000)

This paper deals with the computation of reciprocals, square roots, inverse square roots, and some elementary functions using small tables, small multipliers, and, for some functions, a final "large" (almost full-length) multiplication. We propose a method, based on argument reduction and series expansion, that allows fast evaluation of these functions in high precision. The strength of this method is that the same scheme allows the computation of all these functions. We estimate the delay, the size/number of tables, and the size/number of multipliers and compare with other related methods.
Energy-Preserving Ambisonic Decoding (2011)

Ambisonics with height is a three-dimensional sound field reproduction technique for spherical loudspeaker arrangements surrounding the reproduction area. It employs spherical harmonics up to a given order to expand incident sound fields with a limited angular resolution. The expansion coefficients describe the spatial sound scene. For reproduction, these coefficients are decoded to a set of surrounding loudspeakers. Common decoding approaches either sample the spherical harmonic excitation at the loudspeaker positions or match the excitation modes of a continuous sound field to those of the loudspeakers. For well-designed spherical loudspeaker arrays, both decoding approaches achieve good perceptual localization of virtual sound sources. However, both approaches perform unsatisfactorily with non-uniformly arranged arrays. Sounds from directions with only sparse loudspeaker coverage appear with altered loudness levels. This distracting effect results from variations in the decoded energy. The present article demonstrates an improved decoding technique, which preserves the decoded energy. Using available objective estimators, the localization qualities of these energy-preserving decoders are shown to lie between both common decoding approaches.
An erbium-doped multimode optical fiber amplifier (1991)

The authors describe the first experimental study of an erbium-doped multimode fiber amplifier. The focus has been to characterize an intermediate core erbium-doped optical fiber, a fiber that is capable of propagating many guided modes at both the signal and pump wavelengths, and to determine the feasibility of using such an active fiber as a multimode fiber amplifier, by measuring its gain, noise, and pump power requirements. For a 2-m length of a 13- mu m-core erbium-doped fiber, the authors measured gain as high as 16 dB at a signal wavelength of 1543 nm, with approximately 100 mW pump power (980 nm). For these same test conditions, the smallest excess noise factor beta was 42.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Stereoselective addition reactions with chalcogen electrophiles (2006)

The addition of chalcogen electrophiles to alkenes is investigated using sulfur and tellurium electrophiles. These reagents have been prepared in analogy to the known and well-investigated selenium counterparts.
Morphine clearance in children: Does race or genetics matter? (2012)

Race of the child is an important factor in perioperative intravenous morphine's clearance and its potential role in personalizing analgesia with morphine needs further investigation.
Genome replication engineering assisted continuous evolution (GREACE) to improve microbial tolerance for biofuels production (2013)

We developed a novel GREACE method using "Mutagenesis coupled-with Selection" as core principle. Successful isolation of E. coli strains with improved n-butanol and acetate tolerances demonstrated the potential of GREACE as a promising method for strain improvement in biofuels production.
Replicon-based vectors of positive strand RNA viruses. (2000)

Vectors based on self-replicating RNAs (replicons) of positive strand RNA viruses are becoming powerful tools for gene expression in mammalian cells and for the development of novel antiviral and anticancer vaccines. A relatively small genome size and simple procedure allow rapid generation of recombinants. Cytoplasmic RNA amplification eliminates nuclear involvement and leads to extremely high levels of gene expression, and continuous synthesis of double stranded RNA results in induction of enhanced immune responses, making these vectors unique among other gene expression systems. Both cytopathic replicon vectors allowing short-term transient expression, and non-cytopathic replicon vectors allowing long-term stable expression, are now available with the choice of vector depending on particular applications.
Long-term Neurobehavioral Effects of Mild Poisonings with Organophosphate and n-Methyl Carbamate Pesticides among Banana Workers (2002)

Organophosphate poisoning has been associated with chronic neurobehavioral dysfunction, but no epidemiologic data exist with regard to long-term consequences from carbamate poisoning. This cross-sectional study evaluated the neurobehavioral performances of 81 banana workers who, on average 27 months earlier, had received medical attention not requiring hospitalization for mild occupational poisoning by either an organophosphate or a carbamate pesticide. These performances were compared with those of 130 banana workers who had never sought medical attention for pesticide poisoning. Poisoned subjects did less well than controls on tests measuring psychomotor and visuomotor skills, language function, and affect, the differences being significant for coding skills on the Digit-Symbol test and two tests of neuropsychiatric symptoms. These deficits, in particular a marked increase of neuropsychiatric symptoms, occurred among the organophosphate-poisoned subjects, but small deficits in performance were also seen in the carbamate-poisoned subjects. The performances of the previously poisoned subjects who had had contact with cholinesterase inhibitors within three months before testing were particularly poor. These findings in workers with mild poisoning are consistent with previous findings of persistent damage to the central nervous system from organophosphate poisoning. The possibility of persistent neurobehavioral effects associated with poisonings by nmethyl carbamate insecticides cannot be excluded. Workers with histories of poisoning may be more susceptible to neurobehavioral effects with subsequent exposures.