gebhart/patrepeval huggingface dataset:
Casing centralization calculation in horizontal wells using PC's (1991)

In this paper the three-moments-equation method is used to calculate casing deflection and centralizer spacing in horizontal wells. This method, when used with a PC, makes it possible to study in detail the deflection of a casing string as a continuous beam in a horizontal wellbore. In particular, this approach makes it possible to study the near-end effect of the casing shoe on the deflection of the other spans in the casing string. Casing deflection in the transition zone where the centralizer spacing changes from one value to another and the casing deflection for an overhang at the casing shoe can also be studied. Examples are presented.
Kalman-Filter-Based Orientation Determination Using Inertial/Magnetic Sensors: Observability Analysis and Performance Evaluation (2011)

In this paper we present a quaternion-based Extended Kalman Filter (EKF) for estimating the three-dimensional orientation of a rigid body. The EKF exploits the measurements from an Inertial Measurement Unit (IMU) that is integrated with a tri-axial magnetic sensor. Magnetic disturbances and gyro bias errors are modeled and compensated by including them in the filter state vector. We employ the observability rank criterion based on Lie derivatives to verify the conditions under which the nonlinear system that describes the process of motion tracking by the IMU is observable, namely it may provide sufficient information for performing the estimation task with bounded estimation errors. The observability conditions are that the magnetic field, perturbed by first-order Gauss-Markov magnetic variations, and the gravity vector are not collinear and that the IMU is subject to some angular motions. Computer simulations and experimental testing are presented to evaluate the algorithm performance, including when the observability conditions are critical.
General Catalysts for the Suzuki–Miyaura and Sonogashira Coupling Reactions of Aryl Chlorides and for the Coupling of Challenging Substrate Combinations in Water (2005)

Amphiphilic phosphine ligands (see structures; Cy=cyclohexyl) were prepared and utilized in palladium-catalyzed Suzuki–Miyaura and Sonogashira coupling reactions in water or water/organic biphasic solvents, providing excellent yields of functionalized biaryls and aryl alkynes, respectively. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z502017_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Development of pressure-driven micro active catheter using membrane micro emboss following excimer laser ablation (MeME-X) process (2009)

The world's smallest micro active catheter of φ∼300µm was successfully fabricated using membrane micro emboss following excimer laser ablation (MeME-X) process. The catheter has a one-sided hollow bellows at the tip made of thin polymer membrane. The bellows is composed of a series of folded micro-chambers and microchannels connecting the micro-chambers. The folded-chambers expand on one side by increasing inner water pressure using a syringe, thus the whole bellows bends toward one direction within 0 to 180 degree. This micro active catheter should be useful for safe intravascular surgery in narrow and complicated blood vessels. Moreover, the nonelectrical actuation mechanism of this catheter can be widely applied to micro-actuators and micro-robots which need high safety.
Cooperation between 4-1BB and ICOS in the Immune Response to Influenza Virus Revealed by Studies of CD28/ICOS-Deficient Mice (2005)

CD28, ICOS, and 4-1BB each play distinct roles in the CD8 T cell response to influenza virus. CD28-/- mice are severely impaired in primary CD8 T cell expansion and fail to mount a secondary response to influenza. Influenza-specific CD8 T cells expand normally in ICOS-/- mice, with only a small and transient defect late in the primary response and an unimpaired secondary response. Conversely, 4-1BB/4-1BBL interaction is dispensable for the primary CD8 T cell response to influenza, but maintains CD8 T cell survival and controls the size of the secondary response. Previous results showed that a single dose of agonistic anti-4-1BB Ab at priming allowed partial restoration of primary CD8 T cell expansion and full recovery of the secondary CD8 T cell responses to influenza in CD28-/- mice. In this study we show that anti-4-1BB fails to correct the CD8 T cell defect in CD28-/-ICOS-/- mice, suggesting that ICOS partially compensates for CD28 in this model. In support of this hypothesis, we found that anti-4-1BB enhances ICOS expression on both T cell subsets and that anti-4-1BB and anti-ICOS can synergistically activate CD4 and CD8 T cells. Furthermore, ICOS and 4-1BB can cooperate to directly stimulate isolated CD28-/- CD8 T cells. These results reveal a novel interaction between the ICOS and 4-1BB costimulatory pathways as well as unexpected redundancy between CD28 and ICOS in primary CD8 T cell expansion. These findings have implications for costimulation of human T cell responses in diseases such as AIDS or rheumatoid arthritis, in which CD28- T cells accumulate.
Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent (1996)

We have recently reported that a 16-amino acid long polypeptide corresponding to the third helix of the DNA binding domain (homeodomain) of Antennapedia, a Drosophila transcription factor, is internalized by cells in culture (Derossi, D., Joliot, A. H., Chassaing, G., and Prochiantz, A.(1994) J. Biol. Chem. 269, 10444-10450). The capture of the homeodomain and of its third helix at temperatures below 10 degrees C raised the problem of the mechanism of internalization. The present demonstration, that a reverse helix and a helix composed of D-enantiomers still translocate across biological membranes at 4 and 37 degrees C strongly suggests that the third helix of the homeodomain is internalized by a receptor-independent mechanism. The finding that introducing 1 or 3 prolines in the structure does not hamper internalization also demonstrates that the alpha-helical structure is not necessary. The data presented are compatible with a translocation process based on the establishment of direct interactions with the membrane phospholipids. The third helix of the homeodomain has been used successfully to address biologically active substances to the cytoplasm and nucleus of cells in culture (Théodore, L., Derossi, D., Chassaing, G., Llirbat, B., Kubes, M., Jordan, P., Chneiweiss, H., Godement, P., and Prochiantz, A.(1995) J. Neurosci. 15, 7158-7167). Therefore, in addition to their physiological implications (Prochiantz, A., and Théodore, L.(1995) BioEssays 17, 39-45), the present results open the way to the molecular design of cellular vectors.
An empirical investigation of proposals in collaborative dialogues (1998)

We describe a corpus-based investigation of proposals in dialogue. First, we describe our DRI compliant coding scheme and report our inter-coder reliability results. Next, we test several hypotheses about what constitutes a well-formed proposal.
Laron syndrome due to a post-receptor defect: response to IGF-I treatment. (1993)

Three siblings with Laron syndrome (LS) and normal serum growth hormone binding protein (GHBP) are described. Basal serum levels of hGH were high and IGF-1 low, and in contradistinction to the classical form of the disease serum GHBP and IGFBP-3 were normal in these patients. After 7 days of human growth hormone administration serum IGFBP-3 levels as well as the number of red blood cell IGF receptor sites increased. After short- and long-term IGF-1 administration the IGF-1 receptor binding capacity as well as the number of IGF receptor sites decreased to levels found in control subjects. One year treatment with IGF-1 increased the growth velocity by 47-96% in the two older children. It is concluded that the findings described are compatible with a normal GH receptor and normal signal transmission for IGFBP-3 synthesis but a defect exists in the post-GH receptor mechanism for the generation of IGF-1. This is the first description of this type of defect leading to a variant of Laron syndrome.
Near-infrared phosphorescence: materials and applications (2013)

Room-temperature phosphorescent materials that emit light in the visible (red, green, and blue; from 400 to 700 nm) have been a major focus of research and development during the past decades, due to their applications in organic light-emitting diodes (OLEDs), light-emitting electrochemical cells, photovoltaic cells, chemical sensors, and bio-imaging. In recent years, near-infrared (NIR) phosphorescence beyond the visible region (700-2500 nm) has emerged as a new, promising, and challenging research field with potential applications toward NIR OLEDs, telecommunications, night vision-readable displays. Moreover, NIR phosphorescence holds promise for in vivo imaging, because cells and tissues exhibit little absorption and auto-fluorescence in this spectral region. This review describes the overall progress made in the past ten years on NIR phosphorescent transition-metal complexes including Cu(I), Cu(II), Cr(III), Re(I), Re(III), Ru(II), Os(II), Ir(III), Pt(II), Pd(II), Au(I), and Au(III) complexes, with a primary focus on material design complemented with a selection of optical, electronic, sensory, and biologic applications. A critical comparison of various NIR phosphorescent materials reported in the literature and a blueprint for future development in this field are also provided.
A Diversity-Promoting Objective Function for Neural Conversation Models (2016)

Jiwei Li, Michel Galley, Chris Brockett, Jianfeng Gao, Bill Dolan. Proceedings of the 2016 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies. 2016.
O2‐05‐05: Results of the first‐in‐man study with the active Aβ Immunotherapy CAD106 in Alzheimer patients (2009)

CAD106 is an immunotherapeutic vaccine comprising the Aß1-6 peptide coupled to the Qß virus-like particle. In animals, CAD106 induced Aß-antibody titers without activating Aß-reactive T-cells. Administration of CAD106 to APP transgenic mice showed a reduction of amyloid accumulation in the brain. Safety, tolerability and immunogenicity of CAD106 was assessed in a first-in-man study CCAD106A2101, a 52-week, two-center, randomized, double-blind, placebo-controlled, parallel group study in patients with mild to moderate AD in Sweden. Patients were administered 50ug CAD106/placebo at weeks 0/6/18 in Cohort I, and 150ug CAD106/placebo at weeks 0/2/6 in Cohort II. 58 Caucasians (30m, 28f) with MMSE 16-26 were randomized in two semi-overlapping cohorts. Results of Cohort I were presented previously. The mean age was 69.3 and 68 years in Cohort I and II, respectively. One Cohort II patient discontinued the study due to withdrawal of consent at week 26. No cases of meningoencephalitis were detected clinically, and no relevant concerns were raised by the repeated CSF and MRI assessments. Adverse events were predominantly mild. Between the cohorts, an increase in injection-related reactions was observed in patients receiving CAD106, with the most common reaction being injection-site erythema (CAD106 Cohort I: 4%; vs CAD106 Cohort II: 64%). Serious adverse events were reported in Cohort I for 4/24 (17%) patients on CAD106 and 1/7 (14%) on placebo, and in Cohort II for 4/22 (18%) patients on CAD106 and none on placebo. All SAEs were considered unrelated to the study medication by the investigator and the DSMB. CAD106 induced a measurable specific antibody response against Aß in 16/24 Cohort I patients and in 18/22 Cohort II patients. Peak mean Aß IgG antibody titers were observed at week 8 in both cohorts with a 2-fold increase observed in Cohort II. Exploratory outcome measures (clinical, CSF and MRI) did not differ significantly in either treatment group or cohort. Overall, the results of this study support further development of CAD106. In the two ongoing studies in Europe and the US, further data on safety, tolerability and immunogenicity of CAD106 150 ug administered at 0/6/12 or 0/2/6 weeks are being gathered.
A novel single-device DC method for extraction of the effective mobility and source-drain resistances of fresh and hot-carrier degraded drain-engineered MOSFET's (1998)

A new DC technique, the drain current-conductance method (DCCM), has been developed to extract the gate bias dependent effective channel mobility (/spl mu//sub eff/), and source and drain series resistance (R/sub s/ and R/sub d/) of drain-engineered MOSFET's. The extraction of /spl mu//sub eff/, R/sub e/, and R/sub d/ by DCCM is based on the DC measurements of drain current and conductance of a single device. The negligible difference between the measured and modeled (using the extracted parameters) linear drain current showed that the DCCM is accurate and effective for devices with different graded junction structures and channel lengths. Asymmetry between R/sub s/ and R/sub d/ for LDD p-MOSFET's was found to be more significant than for LATID n-MOSFET's. This asymmetry has invalidated many methods which utilized the assumptions of R/sub d/=R/sub s/ for the extraction of device parameters. The DCCM was further applied to devices with nonuniform hot-carrier degradation. The /spl mu//sub eff/, R/sub s/, and R/sub d/ of LATID n-MOSFET's degraded under different hot-carrier stress conditions were extracted. The increase in R/sub d/ is found to dominate the initial phase of hot-carrier degradation while the decrease in /spl mu//sub eff/ intensifies as the stress duration increases. The extracted parameters have provided physical insight into the asymmetries of graded junctions and degradation mechanisms of hot-carrier stressed MOSFET's, The DCCM is especially useful for the extraction of SPICE parameters that are usable in circuit and reliability simulation.
Protecting American Software in Japan, 8 Computer L.J. 111 (1988) (1988)

The development of a Japanese software market has captured the interest of American software makers. 1 For American manufacturers seeking exports to Japan, the Japanese software market looks lucrative.According to a 1985 survey, Japanese software sales were growing more than twenty per cent annually, and fourteen top Japanese companies grossed more than Y10 billion. 2 Also, the top twenty software firms grossed an average profit of 6.0 percent.The average gross profit for all the listed Japanese companies was 3.1 percent during this period-indicating that the net profits of the top software companies rose as well. 3 Additionally, because of the expected increased demand for bank online systems and telecommunications projects, the future looks optimistic.4 Consequently, a place exists for American software firms in Japan especially since these firms are ahead of their Japanese competitors in software technology.
Frontiers of robotic endoscopic capsules: a review (2016)

Digestive diseases are a major burden for society and healthcare systems, and with an aging population, the importance of their effective management will become critical. Healthcare systems worldwide already struggle to insure quality and affordability of healthcare delivery and this will be a significant challenge in the midterm future. Wireless capsule endoscopy (WCE), introduced in 2000 by Given Imaging Ltd., is an example of disruptive technology and represents an attractive alternative to traditional diagnostic techniques. WCE overcomes conventional endoscopy enabling inspection of the digestive system without discomfort or the need for sedation. Thus, it has the advantage of encouraging patients to undergo gastrointestinal (GI) tract examinations and of facilitating mass screening programmes. With the integration of further capabilities based on microrobotics, e.g. active locomotion and embedded therapeutic modules, WCE could become the key-technology for GI diagnosis and treatment. This review presents a research update on WCE and describes the state-of-the-art of current endoscopic devices with a focus on research-oriented robotic capsule endoscopes enabled by microsystem technologies. The article also presents a visionary perspective on WCE potential for screening, diagnostic and therapeutic endoscopic procedures.
Synthesis and Biological Activity of Novel Epothilone Aziridines (2001)

[reaction: see text]. A series of 12alpha,13alpha-aziridinyl epothilone derivatives were synthesized in an efficient manner from epothilone A. The final semisynthetic route involves a formal double-inversion of stereochemistry at both the C12 and C13 positions. All aziridine analogues were tested for effects on tubulin binding polymerization and cytotoxicity. The results indicate that the aziridine moiety is a viable isosteric replacement for the epoxide in the case of epothilones.
A minimum squared-error framework for generalized sampling (2006)

We treat the problem of reconstructing a signal from its nonideal samples where the sampling and reconstruction spaces as well as the class of input signals can be arbitrary subspaces of a Hilbert space. Our formulation is general, and includes as special cases reconstruction from finitely many samples as well as uniform-sampling of continuous-time signals, which are not necessarily bandlimited. To obtain a good approximation of the signal in the reconstruction space from its samples, we suggest two design strategies that attempt to minimize the squared-norm error between the signal and its reconstruction. The approaches we propose differ in their assumptions on the input signal: If the signal is known to lie in an appropriately chosen subspace, then we propose a method that achieves the minimal squared error. On the other hand, when the signal is not restricted, we show that the minimal-norm reconstruction cannot generally be obtained. Instead, we suggest minimizing the worst-case squared error between the reconstructed signal, and the best possible (but usually unattainable) approximation of the signal within the reconstruction space. We demonstrate both theoretically and through simulations that the suggested methods can outperform the consistent reconstruction approach previously proposed for this problem.
Fab Chains As an Efficient Heterodimerization Scaffold for the Production of Recombinant Bispecific and Trispecific Antibody Derivatives (2000)

Due to their multispecificity and versatility, bispecific Abs (BsAbs) are promising therapeutic tools in tomorrow's medicine. Especially intermediate-sized BsAbs that combine body retention with tissue penetration are valuable for therapy but necessitate expression systems that favor heterodimerization of the binding sites for large-scale application. To identify heterodimerization domains to which single-chain variable fragments (scFv) can be fused, we compared the efficiency of heterodimerization of CL and CH1 constant domains with complete L and Fd chains in mammalian cells. We found that the isolated CL:CH1 domain interaction was inefficient for secretion of heterodimers. However, when the complete L and Fd chains were used, secretion of L:Fd heterodimers was highly successful. Because these Fab chains contribute a binding moiety, C-terminal fusion of a scFv molecule to the L and/or Fd chains generated BsAbs or trispecific Abs (TsAbs) of intermediate size (75-100 kDa). These disulfide-stabilized bispecific Fab-scFv ("bibody") and trispecific Fab-(scFv)(2) ("tribody") heterodimers represent up to 90% of all secreted Ab fragments in the mammalian expression system and possess fully functional binding moieties. Furthermore, both molecules recruit and activate T cells in a tumor cell-dependent way, whereby the trispecific derivative can exert this activity to two different tumor cells. Thus we propose the use of the disulfide-stabilized L:Fd heterodimer as an efficient platform for production of intermediate-sized BsAbs and TsAbs in mammalian expression systems.
Increasing TCP's Initial Window (2013)

This document proposes an experiment to increase the permitted TCP initial window (IW) from between 2 and 4 segments, as specified in RFC 3390, to 10 segments with a fallback to the existing recommendation when performance issues are detected.It discusses the motivation behind the increase, the advantages and disadvantages of the higher initial window, and presents results from several large-scale experiments showing that the higher initial window improves the overall performance of many web services without resulting in a congestion collapse.The document closes with a discussion of usage and deployment for further experimental purposes recommended by the IETF TCP Maintenance and Minor Extensions (TCPM) working group.
Effects of 420‐nm intense pulsed light in an acne animal model (2012)

A 420-nm intense pulsed light may exert its beneficial effects on inflammatory acne by reducing the levels of P. acnes and secondarily reducing inflammation induced by the bacteria.
Telomestatin, a Novel Telomerase Inhibitor from Streptomyces anulatus (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTelomestatin, a Novel Telomerase Inhibitor from Streptomyces anulatusKazuo Shin-ya, Konstanty Wierzba, Ken-ichi Matsuo, Toshio Ohtani, Yuji Yamada, Kazuo Furihata, Yoichi Hayakawa, and Haruo SetoView Author Information Institute of Molecular and Cellular Biosciences The University of Tokyo Bunkyo-ku, Tokyo 113-0032, Japan Graduate School of Agricultural and Life Sciences The University of Tokyo Bunkyo-ku, Tokyo 113-8657, Japan Cite this: J. Am. Chem. Soc. 2001, 123, 6, 1262–1263Publication Date (Web):January 20, 2001Publication History Received11 November 2000Published online20 January 2001Published inissue 1 February 2001https://pubs.acs.org/doi/10.1021/ja005780qhttps://doi.org/10.1021/ja005780qrapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views4338Altmetric-Citations424LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Carbon,Chemical structure,Coupling reactions,Inhibitors,Peptides and proteins Get e-Alerts