gebhart/patrepeval huggingface dataset:
From structure to function: possible biological roles of a new widespread protein family binding hydrophobic ligands and displaying a nucleotide binding site (1995)

A cytosolic 21-23 kDa protein isolated from bovine brain was demonstrated to bind hydrophobic ligands, particularly phosphatidylethanolamine. The protein was encountered in numerous tissues of several species. High expression of the mRNA encoding the 21-23 kDa protein was found in rat testes. Immunohistochemical studies showed the presence of the 21-23 kDa protein in the elongated spermatids and epididymal fluid of rat testis and in brain oligodendrocytes of developing rats. As the bovine, human and rat brain 21-23 kDa proteins had only few sequence homologies with already know proteins, ti was concluded that they belong to a new protein family. In order to get additional information on the structural features of the 21-23 kDa protein, we built a molecular model which displayed a nucleotide binding site. The affinity of the bovine brain 21-23 kDa protein towards nucleotides as well as its association with cytosolic proteins and small GTP-binding proteins were demonstrated. Recently, significant sequence homologies were found with an antigen from Onchocerca volvulus, a fruit fly odorant-binding protein and the yeast protein TFS1 which is a dosage-dependent suppressor of CDC25 mutations. A positive regulation of RAS is carried out by CDC25 product which facilitates the GDP/GTP exchange on RAS proteins. These results imply that 21-23 kDa proteins function in oxidoreduction reactions and signal mechanisms during cell growth and maturation.
Deep Face Recognition (2015)

The goal of this paper is face recognition – from either a single photograph or from a set of faces tracked in a video. Recent progress in this area has been due to two factors: (i) end to end learning for the task using a convolutional neural network (CNN), and (ii) the availability of very large scale training datasets. We make two contributions: first, we show how a very large scale dataset (2.6M images, over 2.6K people) can be assembled by a combination of automation and human in the loop, and discuss the trade off between data purity and time; second, we traverse through the complexities of deep network training and face recognition to present methods and procedures to achieve comparable state of the art results on the standard LFW and YTF face benchmarks.
Determination of diffusion mechanisms in amorphous silicon (1992)

We have established experimentally and theoretically that transition metals in amorphous Si undergo direct interstitial diffusion that is retarded by temporary trapping at the defects intrinsic to the amorphous structure. The diffusion of Cu, Zn, Pd, Ag, Pt, and Au has been investigated by means of Rutherford-backscattering spectrometry and that of Au tracer atoms by neutron-activation and sputter-sectioning analysis. The data can be fitted using the foreign-atom interstitial diffusion coefficients in crystalline Si modified due to the presence of traps with concentrations between 0.2 and 1 at.% and trapping enthalpies of about 0.9 eV.
Reactivation of rheumatoid arthritis after pregnancy: Increased phagocyte and recurring lymphocyte gene activity (2008)

Our findings indicate that innate immune functions play an important role in postpartum reactivation of arthritis. However, this may depend not only on the monocyte itself, but also on the recurrence of lymphocyte functions postpartum and thus on a critical interaction between both arms of the immune system.
Iron-Based Catalysts with Improved Oxygen Reduction Activity in Polymer Electrolyte Fuel Cells (2009)

Iron-based catalysts for the oxygen-reduction reaction in polymer electrolyte membrane fuel cells have been poorly competitive with platinum catalysts, in part because they have a comparatively low number of active sites per unit volume. We produced microporous carbon-supported iron-based catalysts with active sites believed to contain iron cations coordinated by pyridinic nitrogen functionalities in the interstices of graphitic sheets within the micropores. We found that the greatest increase in site density was obtained when a mixture of carbon support, phenanthroline, and ferrous acetate was ball-milled and then pyrolyzed twice, first in argon, then in ammonia. The current density of a cathode made with the best iron-based electrocatalyst reported here can equal that of a platinum-based cathode with a loading of 0.4 milligram of platinum per square centimeter at a cell voltage of >/=0.9 volt.
Methylene Blue Reduced Abnormal Tau Accumulation in P301L Tau Transgenic Mice (2012)

In neurodegenerative disorders, abnormally hyperphosphorylated and aggregated tau accumulates intracellularly, a mechanism which is thought to induce neuronal cell death. Methylene blue, a type of phenothiazine, has been reported to inhibit tau aggregation in vitro. However, the effect of methylene blue in vivo has remained unknown. Therefore, we examined whether methylene blue suppresses abnormal tau accumulation using P301L tau transgenic mice. At 8 to 11 months of age, these mice were orally administered methylene blue for 5 months. Subsequent results of Western blotting analysis revealed that this agent reduced detergent-insoluble phospho-tau. Methylene blue may have potential as a drug candidate for the treatment of tauopathy.
Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours (2008)

The mutation cluster region (MCR) of adenomatous polyposis coli (APC) is located within the central part of the open reading frame, overlapping with the region encoding the 20 amino acid repeats (20R) that are beta-catenin-binding sites. Each mutation in the MCR leads to the synthesis of a truncated APC product expressed in a colorectal tumour. The MCR extends from the 3' border of the first 20R coding region to approximately the middle of the third 20R coding region, reflecting both positive and negative selections of the N- and C-terminal halves of the APC protein in colon cancer cells, respectively. In contrast, the second 20R escapes selection and can be either included or excluded from the truncated APC products found in colon cancer cells. To specify the functional outcome of the selection of the mutations, we investigated the beta-catenin binding capacity of the first three 20R in N-terminal APC fragments. We found in co-immunoprecipitation and intracellular co-localization experiments that the second 20R is lacking any beta-catenin binding activity. Similarly, we also show that the tumour-associated truncations abolish the interaction of beta-catenin with the third 20R. Thus, our data provide a functional definition of the MCR: the APC fragments typical of colon cancer are selected for the presence of a single functional 20R, the first one, and are therefore equivalent relative to beta-catenin binding.
DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge (2013)

We have previously shown that macaques vaccinated with DNA vectors expressing SIVmac239 antigens developed potent immune responses able to reduce viremia upon high-dose SIVmac251 challenge. To further improve vaccine-induced immunity and protection, we combined the SIVmac239 DNA vaccine with protein immunization using inactivated SIVmac239 viral particles as protein source. Twenty-six weeks after the last vaccination, the animals were challenged intrarectally at weekly intervals with a titrated dose of the heterologous SIVsmE660. Two of DNA-protein coimmunized macaques did not become infected after 14 challenges, but all controls were infected by 11 challenges. Vaccinated macaques showed modest protection from SIVsmE660 acquisition compared with naïve controls (P = 0.050; stratified for TRIM5α genotype). Vaccinees had significantly lower peak (1.6 log, P = 0.0048) and chronic phase viremia (P = 0.044), with 73% of the vaccinees suppressing viral replication to levels below assay detection during the 40-wk follow-up. Vaccine-induced immune responses associated significantly with virus control: binding antibody titers and the presence of rectal IgG to SIVsmE660 Env correlated with delayed SIVsmE660 acquisition; SIV-specific cytotoxic T cells, prechallenge CD4(+) effector memory, and postchallenge CD8(+) transitional memory cells correlated with control of viremia. Thus, SIVmac239 DNA and protein-based vaccine protocols were able to achieve high, persistent, broad, and effective cellular and humoral immune responses able to delay heterologous SIVsmE660 infection and to provide long-term control of viremia. These studies support a role of DNA and protein-based vaccines for development of an efficacious HIV/AIDS vaccine.
Two E2F Sites in the Arabidopsis MCM3 Promoter Have Different Roles in Cell Cycle Activation and Meristematic Expression (2002)

The commitment to DNA replication is a key step in cell division control. The Arabidopsis MCM3 homologue forms part of the mini chromosome maintenance (MCM) complex involved in the initiation of DNA replication at the transition G(1)/S. Consistent with its role at the G(1)/S transition we show that the AtMCM3 gene is transcriptionally regulated at S phase. The 5' region of this gene contains several E2F consensus binding sites, two of which match the human consensus closely and whose roles have been studied here. The identity of the two sequences as E2F binding sites has been confirmed by electrophoretic mobility shift assay analyses. Furthermore the promoter is activated by AtE2F-a and AtDP-a factors in transient expression studies. One of the E2F binding sites is shown to be responsible for the G(2)-specific repression of the promoter in synchronized cell suspension cultures. In contrast, the second E2F binding site has a role in meristem-specific expression in planta as deletion of this site eliminates the expression of a reporter gene in root and apical meristems. Thus two highly similar E2F binding sites in the promoter of the MCM3 gene are responsible for different cell cycle regulation or developmental expression patterns depending on the cellular environment.
Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent (2010)

Idiopathic pulmonary fibrosis (IPF) is a destructive inflammatory disease with limited therapeutic options. To better understand the inflammatory responses that precede and concur with collagen deposition, we used three models of pulmonary fibrosis and identify a critical mechanistic role for IL-17A. After exposure to bleomycin (BLM), but not Schistosoma mansoni eggs, IL-17A produced by CD4(+) and gammadelta(+) T cells induced significant neutrophilia and pulmonary fibrosis. Studies conducted with C57BL/6 il17a(-/-) mice confirmed an essential role for IL-17A. Mechanistically, using ifngamma(-/-), il10(-/-), il10(-/-)il12p40(-/-), and il10(-/-)il17a(-/-) mice and TGF-beta blockade, we demonstrate that IL-17A-driven fibrosis is suppressed by IL-10 and facilitated by IFN-gamma and IL-12/23p40. BLM-induced IL-17A production was also TGF-beta dependent, and recombinant IL-17A-mediated fibrosis required TGF-beta, suggesting cooperative roles for IL-17A and TGF-beta in the development of fibrosis. Finally, we show that fibrosis induced by IL-1beta, which mimics BLM-induced fibrosis, is also highly dependent on IL-17A. IL-17A and IL-1beta were also increased in the bronchoalveolar lavage fluid of patients with IPF. Together, these studies identify a critical role for IL-17A in fibrosis, illustrating the potential utility of targeting IL-17A in the treatment of drug and inflammation-induced fibrosis.
Estimating the entropy of a signal with applications (2000)

We present a new estimator of the entropy of continuous signals. We model the unknown probability density of data in the form of an AR spectrum density and use regularized long-AR models to identify the AR parameters. We then derive both an analytical expression and a practical procedure for estimating the entropy from sample data. We indicate how to incorporate recursive and adaptive features in the procedure. We evaluate and compare the new estimator with other estimators based on histograms, kernel density models, and order statistics. Finally, we give several examples of applications. An adaptive version of our entropy estimator is applied to detection of law changes, blind deconvolution, and source separation.
Quantum systems with finite Hilbert space (2004)

Quantum systems with finite Hilbert space are considered, and phase-space methods like the Heisenberg–Weyl group, symplectic transformations and Wigner and Weyl functions are discussed. A factorization of such systems in terms of smaller subsystems, based on the Chinese remainder theorem, is studied. The general formalism is applied to the case of angular momentum. In this context, SU(2) coherent states are used for analytic representations. Links between the theory of finite quantum systems and other fields of research are discussed.
Essential Oil of Some Halophyle and Subhalophyle Taxa Artemisia L. from the Central European Mediterranean (2000)

Abstract An analysis is presented of the essential oil of various populations of four similar taxa of the Artemisia L. genus, which colonize salty and subsalty lands [A. caerulescens L. subsp. caerulescens, A. caerulescens L. subsp. cretacea (Fiori) Brilli-Catt. et Gubell., A. densiflora Viv. and A. gallica Willd.]. Their variation was assessed, regarding the systematic similarities as well, which were interpreted in various ways. GC and GC/MS analyses of the oils revealed the constant presence of α and β-thujone and camphor; these results substantially confirm the most recent systematic interpretation, highlighting a notable similarity between the two A. caerulescens subspecies and between A. densiflora and A. gallica.
Surgically induced intracranial contrast enhancement: potential source of diagnostic error in intraoperative MR imaging. (1999)

Surgically induced contrast enhancement is a potential source of error in intraoperative MR imaging. Careful analysis of the location, configuration, and time course of intraoperatively observed intracranial enhancement is critical to avoid confusing surgically induced contrast enhancement with contrast-enhancing, residual tumor.
A hybrid 6H-SiC temperature sensor operational from 25°C to 500°C (1996)

6H-SiC buried-gate n-channel depletion-mode junction field-effect transistors (JFETs) were characterized from 25/spl deg/C to 350/spl deg/C in terms of transconductance (g/sub m/), pinchoff voltage (V/sub P/), output resistance (r/sub o/), input resistance (R/sub in/), drain-to-source current at zero gate-to-source voltage (I/sub DSS/), gate-to-source reverse biased leakage current (I/sub GSS/), off-state drain-to-source current (I/sub DSS(off)/), and noise power spectral density (S/sub V/). The 6H-SiC JFET's were used in a hybrid temperature monitoring circuit (tested from -196/spl deg/C to 500/spl deg/C) fabricated at Auburn University for use in numerous industrial applications. Simulation program with integrated circuit emphasis (SPICE) simulations of the temperature monitoring circuit's output voltage corresponded well with measured data as a function of temperature. Linear regression (LR) analysis of measured data revealed a notably sensitive (/spl sim/2.3 mV//spl deg/), and an eminently linear (correlation coefficient =-0.0996...over 25/spl deg/C to 500/spl deg/C range) relationship between the measured output voltage and temperature. Below -50/spl deg/C, the output became nonlinear, presumably from carrier freeze-out effects. To the best of our knowledge, this represents the first successful implementation of SiC active devices into a temperature sensor which demonstrated stable operation up to 500/spl deg/C.
Effects of GLUT4 expression on insulin resistance in patients with advanced liver cirrhosis (2011)

Decreased glucose tolerance and diabetes are frequently observed in advanced liver cirrhosis patients and may be related to insulin resistance. Glucose transporter-4 (GLUT4), one of the most important glucose transporters, plays a key role in the development of type 2 diabetes. In order to study the mechanism of insulin resistance in liver cirrhosis patients, we measured the insulin sensitivity index and determined the GLUT4 protein and mRNA contents of skeletal muscle by Western blotting and reverse transcription-polymerase chain reaction (RT-PCR), respectively, in normal people and liver cirrhosis patients. The results showed that the levels of glucose, insulin, and C-peptide in two liver cirrhosis groups were higher and the insulin sensitivity index lower than those of the normal control group. The sensitivity of insulin may decrease with the decline of liver function. However, the contents of GLUT4 protein and mRNA in patients with advanced liver cirrhosis were similar to those of normal controls. In conclusion, insulin resistance is observed in patients with advanced liver cirrhosis but may not be correlated with the skeletal contents of GLUT4 protein and mRNA.
2-(1,3-Benzothiazol-2-yl)ethanethioamides in Heterocyclic Synthesis: Novel Synthesis of Pyridine, Pyrido[2,3-d]pyrimidine, Coumarin, Thiazolone and Triazole Derivatives (1998)

M. A. A. Elneairy, T. M. Abdel-Rahman and A. M. Hammad, J. Chem. Res. (S), 1998, 684 DOI: 10.1039/A800137E
Myopathy with hypophosphatasia. (1990)

Three children with hypophosphatasia also had muscle pains, stiffness, and symptoms of proximal lower limb muscle weakness that occurred early in the disorder and were the presenting features in two. A non-progressive myopathy may be an important sign of hypophosphatasia.
The role of ferric carboxymaltose in the treatment of iron deficiency anemia in patients with gastrointestinal disease (2015)

Iron deficiency anemia (IDA) is the most common form of nutritional anemia worldwide. Iron plays a pivotal role in vital functioning of almost every organ system. IDA affects both physical and psychological functioning of humans. Oral iron is considered as first-line therapy for the treatment of IDA due to low cost, good safety profile and ease of administration. However, the absorption of oral iron is affected by several factors and incidence of gastrointestinal side effects can lead to lack of adherence to therapy as well as poor efficacy. This has led to the emergence of intravenous iron therapy which is clearly superior to oral iron with higher increment of hemoglobin levels and rapid replenishment of iron stores. Ferric carboxymaltose (FCM) is a novel non-dextran intravenous iron form which has been approved for use in patients with iron deficiency who have had inadequate response to oral iron therapy, intolerance to oral iron, or nondialysis-dependent chronic kidney disease. The safety and efficacy of using FCM for the treatment of IDA has been demonstrated in several clinical trials. One dose can provide a large amount of iron and has a very short infusion time. It should be considered as first-line therapy in patients with active inflammation like inflammatory bowel disease when gastrointestinal absorption of oral iron may be compromised. It should also be given to patients who have inadequate response to oral iron therapy. It has been shown to be noninferior to other intravenous iron formulations with a good safety profile and produced fewer anaphylactic reactions.
Pairing symmetry in cuprate superconductors (2000)

Pairing symmetry in the cuprate superconductors is an important and controversial topic. The recent development of phase-sensitive tests, combined with the refinement of several other symmetry-sensitive techniques, has for the most part settled this controversy in favor of predominantly $d$-wave symmetry for a number of optimally hole- and electron-doped cuprates. This paper begins by reviewing the concepts of the order parameter, symmetry breaking, and symmetry classification in the context of the cuprates. After a brief survey of some of the key non-phase-sensitive tests of pairing symmetry, the authors extensively review the phase-sensitive methods, which use the half-integer flux-quantum effect as an unambiguous signature for $d$-wave pairing symmetry. A number of related symmetry-sensitive experiments are described. The paper concludes with a brief discussion of the implications, both fundamental and applied, of the predominantly $d$-wave pairing symmetry in the cuprates.
Band-edge exciton in quantum dots of semiconductors with a degenerate valence band: Dark and bright exciton states (1996)

We present a theoretical analysis of the band-edge exciton structure in nanometer-size crystallites of direct semiconductors with a cubic lattice structure or a hexagonal lattice structure which can be described within the framework of a quasicubic model. The lowest energy exciton, eightfold degenerate in spherically symmetric dots, is split into five levels by the crystal shape asymmetry, the intrinsic crystal field (in hexagonal lattice structures), and the electron-hole exchange interaction. Transition oscillator strengths and the size dependence of the splittings have been calculated. Two of the five states, including the ground state, are optically passive (dark excitons). The oscillator strengths of the other three levels (bright excitons) depend strongly on crystal size, shape, and energy band parameters. The relative ordering of the energy levels is also heavily influenced by these parameters. The distance between the first optically active state and the optically forbidden ground exciton state increases with decreasing size, leading to an increase of the Stokes shift in the luminescence. Our results are in good agreement with the size dependence of Stokes shifts obtained in fluorescence line narrowing and photoluminescence experiments in CdSe nanocrystals. Mixing of the dark and bright excitons in an external magnetic field allows the direct optical recombination of the dark exciton ground state. The observed shortening of the luminescence decay time in CdSe nanoncrystals in a magnetic field is also in excellent agreement with the theory, giving further support to the validity of our model. \textcopyright{} 1996 The American Physical Society.