gebhart/patrepeval huggingface dataset:
An infrared study of the reaction of octadecyltrichlorosilane with silica (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn infrared study of the reaction of octadecyltrichlorosilane with silicaC. P. Tripp and M. L. HairCite this: Langmuir 1992, 8, 4, 1120–1126Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April 1992https://doi.org/10.1021/la00040a018Request reuse permissionsArticle Views1815Altmetric-Citations242LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alertsclose Get e-Alerts
Anti-inflammatory Drugs Protect Against Alzheimer Disease at Low Doses (2000)

This study does not support a high-dose anti-inflammatory action of nonsteroidal anti-inflammatory drugs or aspirin in AD. Potential mechanisms for the beneficial effects of these medications are discussed.
Resistance to HIV Integrase Strand Transfer Inhibitors Among Clinical Specimens in the United States, 2009–2012 (2013)

Approximately 1 in 6 US patients undergoing integrase GRT for clinical decision making harbors significant resistance, with Q148 and N155 pathways equally common. Dolutegravir is likely to have full or partial activity against most variants observed.
From Keyword Search to Exploration: How Result Visualization Aids Discovery on the Web (2008)

A key to the Web's success is the power of search. The elegant way in which search results are returned is usually remarkably effective. However, for exploratory search in which users need to learn, discover, and understand novel or complex topics, there is substantial room for improvement. Human computer interaction researchers and web browser designers have developed novel strategies to improve Web search by enabling users to conveniently visualize, manipulate, and organize their Web search results. This monograph offers fresh ways to think about search-related cognitive processes and describes innovative design approaches to browsers and related tools. For instance, while key word search presents users with results for specific information (e.g., what is the capitol of Peru), other methods may let users see and explore the contexts of their requests for information (related or previous work, conflicting information), or the properties that associate groups of information assets (group legal decisions by lead attorney). We also consider the both traditional and novel ways in which these strategies have been evaluated. From our review of cognitive processes, browser design, and evaluations, we reflect on the future opportunities and new paradigms for exploring and interacting with Web search results.
Singapore Social Work Students: Attitudes toward Older Adults (2000)

Using the Sanders, Montgomery, Pittman and Balkwell (1984) instrument, this study found that the attitudes of a sample of undergraduate Singaporean students (n = 201) toward older adults were in the neutral range. A small minority (5.6%) was planning a career in gerontology. Comparisons of the findings were made with an American sample. Implications for social work education and future research were discussed.
A Global Survey of Gene Regulation during Cold Acclimation in Arabidopsis thaliana (2005)

Many temperate plant species such as Arabidopsis thaliana are able to increase their freezing tolerance when exposed to low, nonfreezing temperatures in a process called cold acclimation. This process is accompanied by complex changes in gene expression. Previous studies have investigated these changes but have mainly focused on individual or small groups of genes. We present a comprehensive statistical analysis of the genome-wide changes of gene expression in response to 14 d of cold acclimation in Arabidopsis, and provide a large-scale validation of these data by comparing datasets obtained for the Affymetrix ATH1 Genechip and MWG 50-mer oligonucleotide whole-genome microarrays. We combine these datasets with existing published and publicly available data investigating Arabidopsis gene expression in response to low temperature. All data are integrated into a database detailing the cold responsiveness of 22,043 genes as a function of time of exposure at low temperature. We concentrate our functional analysis on global changes marking relevant pathways or functional groups of genes. These analyses provide a statistical basis for many previously reported changes, identify so far unreported changes, and show which processes predominate during different times of cold acclimation. This approach offers the fullest characterization of global changes in gene expression in response to low temperature available to date.
Quantitative assessment of the use of modified nucleoside triphosphates in expression profiling: differential effects on signal intensities and impacts on expression ratios (2002)

Incorporation of 2-aminoadenosine triphosphate into cRNA targets is a promising method for increasing signal detection in microarrays. Furthermore, this approach can be optimized to minimize impact on yield of amplified material and to increase the number of expression changes that can be detected.
Lymphocyte subsets and expression of differentiation markers in blood and lymphoid organs of rhesus monkeys (1997)

Rhesus macaques are invaluable experimental animals in biomedical research. Using three color flow cytometry, we screened anti-human antibodies for crossreactivity with macaque cells in order to determine the distribution of functionally important lymphocyte subsets in blood, lymph nodes (LN), and spleen. NK-cells are almost completely absent in LN. The percentage of B-cells expressing CD80, CD86, and the level of expression of CD20 is higher in blood than in LN. In contrast, a higher proportion of B-cells in LN stains positive for CD21 and CD35. Whereas the number of CD29hi expressing T-cells is lower, CD69 is expressed on more T-cells in LN than in blood. About one-third of CD8 + T-cells in blood are CD28-, a subset with a unique pattern of antigen expression which cannot be found in LN. In contrast to humans, a relatively high proportion of T-cells in blood also express the co-stimulatory molecules CD80 and CD86. With increasing age, the proportion of B-cells in blood declines, whereas the percentage of T-cells rises. In addition, the proportion of CD29hi expressing T-cells increases among both the CD4+ and CD8+ subsets. Cytometry 29:351–362, 1997. © 1997 Wiley-Liss, Inc.
A 1-D Photonic Band Gap Tunable Optical Filter in (110) Silicon (2007)

In this paper, we describe an electrostatically tunable optical bandpass filter that is fabricated in (110) silicon. Deep reactive-ion etching is the main process that is used to fabricate the overall device structure. To create the highly parallel surfaces that are needed for the photonic band gap elements, electrochemical (KOH) etching of the vertical (111) planes is then used. Back etching is used to release the moving parts. Fiber pigtails are attached in etched alignment grooves, and fiber-fiber insertion loss below 11 dB was obtained. The measured passband width was 3 nm with a tuning range of 8 nm.
Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance (2012)

The substantial use of antibiotics in the clinic, combined with a dearth of new antibiotic classes, has led to a gradual increase in the resistance of bacterial pathogens to these compounds. Among the various mechanisms by which bacteria endure the action of antibiotics, those affecting influx and efflux are of particular importance, as they limit the interaction of the drug with its intracellular targets and, consequently, its deleterious effects on the cell. This review evaluates the impact of porins and efflux pumps on two major types of resistance, namely, mutational and adaptive types of resistance, both of which are regarded as key phenomena in the global rise of antibiotic resistance among pathogenic microorganisms. In particular, we explain how adaptive and mutational events can dramatically influence the outcome of antibiotic therapy by altering the mechanisms of influx and efflux of antibiotics. The identification of porins and pumps as major resistance markers has opened new possibilities for the development of novel therapeutic strategies directed specifically against these mechanisms.
Measurement of Mid-Calcaneal Length on Plain Radiographs (2011)

The authors present a new method to reliably measure the length of the mid-portion of the calcaneus. The authors defined the “mid-calcaneal length” as the line connecting the high point of the convex arc of the posterior subtalar joint facet and the low point of the concave arc of the calcaneocuboid joint. Statistical analysis of 810 measurements taken by 6 observers confirmed high intraobserver reliability, interobserver reliability, and internal consistency (Cronbach coefficient α = .98) and low error rate (Pearson correlation coefficient = .0001). The authors have used this measurement as a tool to determine the change in calcaneal length after osteotomy lengthening procedures and present it as a tool for clinical practice and research. Level of Evidence: Diagnostic, Level III
Myostatin Inhibits Myoblast Differentiation by Down-regulating MyoD Expression (2002)

Myostatin, a negative regulator of myogenesis, is shown to function by controlling the proliferation of myoblasts. In this study we show that myostatin is an inhibitor of myoblast differentiation and that this inhibition is mediated through Smad 3. In vitro, increasing concentrations of recombinant mature myostatin reversibly blocked the myogenic differentiation of myoblasts, cultured in low serum media. Western and Northern blot analysis indicated that addition of myostatin to the low serum culture media repressed the levels of MyoD, Myf5, myogenin, and p21 leading to the inhibition of myogenic differentiation. The transient transfection of C 2 C 12 myoblasts with MyoD expressing constructs did not rescue myostatin-inhibited myogenic differentiation. Myostatin signaling specifically induced Smad 3 phosphorylation and increased Smad 3MyoD association, suggesting that Smad 3 may mediate the myostatin signal by interfering with MyoD activity and expression. Consistent with this, the expression of dominant-negative Smad3 rescued the activity of a MyoD promoterreporter in C 2 C 12 myoblasts treated with myostatin. Taken together, these results suggest that myostatin inhibits MyoD activity and expression via Smad 3 resulting in the failure of the myoblasts to differentiate into myotubes. Thus we propose that myostatin plays a critical role in myogenic differentiation and that the muscular hyperplasia and hypertrophy seen in animals that lack functional myostatin is because of deregulated proliferation and differentiation of myoblasts.
20-O-Acylcamptothecin Derivatives:  Evidence for Lactone Stabilization (2000)

Convincing UV and NMR spectrophotometric evidence is presented which demonstrates that at physiological pH, 7.4, 20-O-acyl derivatives of camptothecin (CPT) are substantially more stable in the lactone form than the 20-OH parent. Additionally, it was determined by HPLC analysis that the lactone ring of a 20-O-ether derivative of CPT underwent endocyclic ring opening at pH > or =8.5, while the lactone ring of 20-O-acyl CPT derivatives remained unaffected. PEG (and other smaller alkyl) 20-O-acyl-CPT derivatives released native CPT at pH > 9.5, which arises from exocyclic cleavage, thus precluding isolation of any open CPT acyl PEG (or alkyl) carboxylate forms.
Primary Structure of a Base Non-Specific and Adenylic Acid Preferential Ribonuclease from Aspergillus saitoi (1990)

The complete primary structure of a base non-specific and adenylic acid preferential RNase (RNase M) from Aspergillus saitoi was determined. The sequence was determined by analysis of the peptides generated by digestion of heat-denatured RNase M with lysylendopeptidase, and the peptides generated from RCM RNase M by digestion with staphylococcal V8 protease or chemical cleavage with BrCN. It consisted of 238 amino acid residues and carbohydrate moiety attached to the 74th asparagine residue. The molecular weight of the protein moiety deduced from the sequence was 26,596. The locations of 10 half cystine residues are almost superimposable on those of RNase Rh from Rhizopus niveus and RNase T2 from Aspergillus oryzae which have similar base specificity. The homology between RNase M and RNase Rh and RNase T2 amounted to 97 and 160 amino acid residues, respectively. The amino acid sequences conserved in the three RNases are concentrated around the three histidine residues, which are supposed to form part of the active sites of these RNases.
Beyond Moran'sI: Testing for Spatial Dependence Based on the Spatial Autoregressive Model (2007)

The statistic known as Moran's I is widely used to test for the presence of spatial dependence in observations taken on a lattice. Under the null hypothesis that the data are independent and identically distributed normal random variates, the distribution of Moran's I is known, and hypothesis tests based on this statistic have been shown in the literature to have various optimality properties. Given its simplicity, Moran's I is also frequently used outside of the formal hypothesis‐testing setting in exploratory analyses of spatially referenced data; however, its limitations are not very well understood. To illustrate these limitations, we show that, for data generated according to the spatial autoregressive (SAR) model, Moran's I is only a good estimator of the SAR model's spatial‐dependence parameter when the parameter is close to 0. In this research, we develop an alternative closed‐form measure of spatial autocorrelation, which we call APLE , because it is an approximate profile‐likelihood estimator (APLE) of the SAR model's spatial‐dependence parameter. We show that APLE can be used as a test statistic for, and an estimator of, the strength of spatial autocorrelation. We include both theoretical and simulation‐based motivations (including comparison with the maximum‐likelihood estimator), for using APLE as an estimator. In conjunction, we propose the APLE scatterplot, an exploratory graphical tool that is analogous to the Moran scatterplot, and we demonstrate that the APLE scatterplot is a better visual tool for assessing the strength of spatial autocorrelation in the data than the Moran scatterplot. In addition, Monte Carlo tests based on both APLE and Moran's I are introduced and compared. Finally, we include an analysis of the well‐known Mercer and Hall wheat‐yield data to illustrate the difference between APLE and Moran's I when they are used in exploratory spatial data analysis.
Luminescence Resonance Energy Transfer (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLuminescence Resonance Energy TransferPaul R. Selvin, Tariq M. Rana, and John E. HearstCite this: J. Am. Chem. Soc. 1994, 116, 13, 6029–6030Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/ja00092a088https://doi.org/10.1021/ja00092a088research-articleACS PublicationsRequest reuse permissionsArticle Views1506Altmetric-Citations178LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Psychosomatic cofactors and psychiatric comorbidity in patients with chronic itch (2006)

As psychiatric comorbidity in dermatology inpatients suffering from chronic itch is high, dermatology departments should aim for an improvement of their psychosomatic consultation and liaison services.
Camelid Immunoglobulins and Their Importance for the New-Born - A Review (2001)

Camelid immunoglobulins differ from all other known antibodies and contradict all common theories on antibody diversity. It was demonstrated that up to 75% of all serum proteins are immunoglobulin G (IgG) molecules lacking light chains. IgG2 and IgG3, which only consist of heavy chains, have a low molecular weight which improves their biodistribution and allows a better tissue penetration. Of special importance is the long complementary determining region (CDR) loop which inserts deep into the active site of an enzyme. This binding property was only observed in experiments to gain structural data and to point out the extraordinary value of heavy chain antibodies as biochemical and pharmacological tools. The acquisition and absorption of adequate amounts of colostral immunoglobulins are essential to the health of the neonate. Pre-colostrum serum IgG levels in camelids are low, with concentrations of 0.26 +/- 10.23 mg/ml. Maximum IgG levels are reached after 24 h and kept at a plateau with concentrations of 24.52 +/- 8.8 mg/dl. IgG concentrations above 10 mg/ml indicate a successful passive transfer. IgG levels decline after 2-5 weeks and a marked increase is observed between 1 and 2 months, indicating that the immune system of the neonate has started to mature. A number of different tests are available for the assessment of IgG serum levels. Single radial immunodiffusion (SRID) is the only method that specifically measures serum IgG concentrations. It is a reliable assay to test failure of passive transfer (FPT). FPT is a major factor in neonatal mortality in camelids, but very little has been published so far. Therapeutic administration of colostrum will provide passive protection against infectious diseases for a 2-3-week period of risk, and the intravenous administration of 20-40 ml of camelid plasma helps to combat FPT.
Distribution of Albumin Nanoparticles in Animals Induced with the Experimental Allergic Encephalomyelitis (2000)

Experimental allergic encephalomyelitis (EAE) is an autoimmune disease characterised by a disruption of the blood-brain barrier (BBB), demyelination and a relevant inflammatory reaction with an intense infiltration of macrophages. These neurological disorders are similar to those observed in the multiple sclerosis (MS) disease. The use of different liposomes and adeno-associated virus has been proposed for improving the treatment of this pathogenesis. The aim of this work was to evaluate the potential and capacity of albumin nanoparticles to reach the central nervous system (CNS) in EAE-induced rats. For this purpose, the distribution of biotinylated nanoparticles within the CNS was studied. Albumin carriers were mainly found in the lumbar portion of the spinal cord, overlying the meningeal and perivascular areas. The optic chiasma, iris and the area of the Purkinje cells of the cerebellum revealed also an intense presence of these carriers. Finally, immunohistochemical studies also revealed that circulating macrophages (ED1), which migrate to damaged sites, and resident activated microglial cells (OX42) were involved in the distribution of albumin nanoparticles. In summary, the use of nanoparticles may be useful for the design of new pharmaceutical dosage forms able to target the lesions associated with alterations of the BBB.
High levels of tissue inhibitor of metalloproteinase‐1 predict poor outcome in patients with breast cancer (1999)

Studies from model systems suggest that matrix metalloproteinases (MMPs) are causally involved in tumor progression while tissue inhibitors of MMPs (TIMPs) prevent this progression. Here, we show that concentrations of TIMP-1 are significantly higher in breast carcinomas than in fibroadenomas. In primary breast cancers, TIMP-1 concentrations increased with increasing tumor size but showed an inverse relationship with estrogen receptor concentrations. In primary breast cancers also, TIMP-1 levels were weakly but significantly correlated with those for MMP-1, proMMP-2, active MMP-2, MMP-3 and proMMP-9. Contrary to what might be expected from published data on model systems, high concentrations of TIMP-1 predicted a poor outcome in patients with breast cancer. We conclude that in human breast cancer, endogenous TIMP-1 does not inhibit tumor progression but may enhance the process. Int. J. Cancer (Pred. Oncol.) 84:44–48, 1999. © 1999 Wiley-Liss, Inc.
Control of Action Potential-Induced Ca2+Signaling in the Soma of Hippocampal Neurons by Ca2+Release from Intracellular Stores (1997)

Stimulus-induced increases in neuronal Ca2+ concentration are important signaling events for transcriptional regulation and neuronal plasticity. Electrical inputs are thought to mediate Ca2+ responses in the soma by triggering action potentials, which in turn open voltage-gated Ca2+ channels in the somatic plasma membrane. It is not yet known to what extent internal Ca2+ amplification contributes to the somatic Ca2+ responses. Here we used fluorescent Ca2+ measurements in cultured hippocampal neurons and report that the amplitude of the somatic Ca2+ increase triggered by field stimulation is independent of the extracellular Ca2+ concentration as long as the concentration is greater than 50 microM. Furthermore, significantly more La3+ has to be added extracellularly for blocking Ca2+ responses, as predicted from the reported La3+ dependence of voltage-gated Ca2+ channels. These measurements suggest that field stimulation-induced somatic Ca2+ responses in hippocampal neurons are largely attributable to Ca2+ release from intracellular stores. Only a small number of Ca2+ ions have to enter across the plasma membrane for this intracellular Ca2+ amplification process to occur. Rapid fluorescence-imaging measurements showed that the internal Ca2+ amplification occurs over 10-15 msec and linearly increases intracellular Ca2+ concentrations for up to 40 action potentials. At a fixed number of field pulses, frequencies of 40 Hz were optimal for somatic Ca2+ increases. Our studies suggest that the opening of intracellular Ca2+ release channels plays a crucial part in shaping the action potential-induced neuronal Ca2+ response.
Extending Mathematical Understanding: EMU (2010)

The key aspects and features of the Extending Mathematical Understanding (EMU) program offered by the Australian Catholic University (ACU) is discussed. The course provides teachers with strategies to pinpoint weaknesses and help students move to the next growth point in their learning.