gebhart/patrepeval huggingface dataset:
Ultra Low Power Composite Free Layer Spin-Orbit Torque MRAM (2018)

Spin-transfer torque MRAM (STT-MRAM) serves as a promising candidate for next generation memory. However, STT-MRAM suffers from tunnel barrier degradation under rapid operations and a poor spin polarization. In contrast, spin-orbit torque MRAM (SOT-MRAM) utilizes spin-orbit interaction at the interface of heavy metal (HM) and ferromagnetic (FM) layers via mechanisms such as the Rashba effect and spin Hall effect (SHE <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1 2</sup> . Since current only flows through the heavy metal in SOT-MRAM, device performance is no longer limited by insulator breakdown. Because no charge current through the FM layer is needed in SOT devices, the other unrecognized benefit of SOT is its compatibility with low-damping magnetic insulators (MI). SOT experiments with YIG/Pt, YIG/Ta, and YIG/W have demonstrated the potential for ultra-low damped switching of YIG in SOT systems <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3 4</sup> . SOT switching has also been demonstrated in TmIG based system <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> . Here, we propose a composite free layer SOT-MRAM (Fig. 1a). The MTJ is a cylinder structure with a diameter D. The free layer consists of an easily switched YIG layer and a thermally stable high anisotropy (K <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">u</sub> ~ 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7</sup> ergs/cc) L1 <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> - FePt or L1 <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> -FePd layer. These two layers are ferromagnetically coupled through the RKKY exchange provided by the Pd layer. It has been shown that exchange coupling between magnetic soft and hard layers can reduce the critical current <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> . Current CoFeB based devices necessitate larger diameters due to the low anisotropy. By adopting FePt or FePd, we can reduce the device area, which is favorable for high density applications. We optimized our device by running micromagnetic simulations in the macrospin approximation. A device of small diameter (D <; 30 nm) with low write energy ( E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">w</sub> <; 1 fJ) can be achieved for 1 ns switching while maintaining thermal stability Δ =60 <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">B</sub> T at room temperature.
Urokinase Receptor and Vascular Endothelial Growth Factor Are Synergistically Associated with the Liver Metastasis of Colorectal Cancer (2001)

Considering recent findings that the urokinase plasminogen activation (PA) system is involved in invasion and vascular endothelial growth factor (VEGF) is involved in angiogenesis of colorectal cancer, we evaluated these factors in the liver metastasis of primary colorectal cancer. Cancer tissues from 71 colorectal cancer patients were assayed quantitatively for antigen levels of urokinase type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor-1 and -2 (PAI-1, PAI-2), and were also assayed immunohistochemically for expression of VEGF protein. Among the PA system factors, both the levels of uPAR and PAI-1 were significantly higher in larger tumors than in smaller ones, and were also significantly higher in tumors that invaded subserosa, serosa or adjacent organs than in mucosal, submucosal tumors or in tumors that invaded the muscle layer. The uPAR levels were significantly higher in tumors with liver metastasis than in those without. VEGF overexpression was significantly more frequent in tumors with lymph node involvement or liver metastasis than in those without. Among the PA system factors, the uPAR levels were significantly higher in tumors with VEGF overexpression and a multivariate analysis revealed that high uPA level and VEGF overexpression were independent risk factors for liver metastasis. The combination of high uPAR level and overexpression of VEGF was associated with the worst prognosis in patients with colorectal cancer. These results suggest that uPAR and VEGF might contribute synergistically to the liver metastasis of colorectal cancer.
Relationship between Tobacco-Specific Nitrosamines and Nitrite from Different Air-Cured Tobacco Varieties (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRelationship between Tobacco-Specific Nitrosamines and Nitrite from Different Air-Cured Tobacco VarietiesHarold R. Burton, Naewanna K. Dye, and Lowell P. BushCite this: J. Agric. Food Chem. 1994, 42, 9, 2007–2011Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/jf00045a033https://doi.org/10.1021/jf00045a033research-articleACS PublicationsRequest reuse permissionsArticle Views400Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
In Situ Cytotoxic and Memory T Cells Predict Outcome in Patients With Early-Stage Colorectal Cancer (2009)

The combined analysis of CD8(+) plus CD45RO(+) cells in specific tumor regions could provide a useful criterion for the prediction of tumor recurrence and survival in patients with early-stage colorectal cancer.
Magnetic force microscopy with 25 nm resolution (1989)

We describe a refined technique for magnetic force microscopy (MFM) which makes possible magnetic imaging with 25 nm resolution. Previous MFM work has relied on a servo system which used the amplitude of the response of an electropolished iron wire cantilever tip to an applied, near-resonance excitation to maintain a constant force gradient between tip and sample. The present results have been obtained with a redesigned instrument which uses a fast lock-in detector to servo on the phase, as opposed to the amplitude of the tip response. With these changes and the use of sharp electrochemically etched Ni tips, it is possible to servo stably on the very weak force gradients encountered in MFM, within 20 nm of the sample surface, and thus obtain 25 nm resolution.
Synthetic carbohydrate-based anticancer vaccines: the Memorial Sloan-Kettering experience (2009)

Malignantly transformed cells can express aberrant cell surface glycosylation patterns, which serve to distinguish them from normal cells. This phenotype provides an opportunity for the development of carbohydrate-based vaccines for cancer immunotherapy. Synthetic carbohydrate-based vaccines, properly introduced through vaccination of a subject with a suitable construct, should be recognized by the immune system. Antibodies induced against these carbohydrate antigens could then participate in the eradication of carbohydrate-displaying tumor cells. Advances in carbohydrate synthetic capabilities have allowed us to efficiently prepare a range of complex, synthetic anticancer vaccine candidates. We describe herein the progression of our longstanding carbohydrate-based anticancer vaccine program, which is now at the threshold of clinical evaluation in several contexts. Our carbohydrate-based anticancer vaccine program has evolved through a number of stages: monomeric vaccines, monomeric clustered vaccines, unimolecular multi-antigenic vaccines and dual-acting vaccines. This account will focus on our recently developed unimolecular multi-antigenic constructs and potential dual-acting constructs, which contain clusters of both carbohydrate and peptide epitopes.
Effect of moisture content on immobilized lipase‐catalyzed triacylglycerol hydrolysis under supercritical carbon dioxide flow in a tubular fixed‐bed reactor (1999)

Abstract Surplus fats and oils were reacted with several lipases under supercritical fluid conditions for the purpose of obtaining value‐added products. Lipases, however, require sufficient moisture content to act as effective biocatalysts. An immobilized lipase from Candida antarctica was chosen to examine the rate of enzyme moisture loss under laboratory ambient conditions and also under supercritical fluid conditions. A more important aspect was to determine the effect of lipase moisture content on the hydrolysis of triacylglycerols under the same supercritical fluid conditions. Under ambient conditions at constant air flow, the immobilized lipase lost water at the rate of 4 to 5%/h, from 48.3% moisture to a final moisture content of 0.2%. Water is known not to be very soluble in supercritical carbon dioxide (SC‐CO 2 ). Nevertheless, under supercritical fluid conditions of 60°C, 4000 psi, and carbon dioxide flow rates of 0.5 or 1 L/min measured as expanded gas, the enzyme moisture loss was approximately 2 to 6%/h. To determine the effect of moisture loss on enzymatic hydrolysis, lipase beds in a tubular reactor with moisture contents of 1.5 to 23.5% were reacted with tripalmitin under supercritical conditions. A lipase with an initial moisture content of 1.5% gave little evidence of hydrolysis whereas those containing 5.4 to 23.5% moisture content resulted in products that contained only palmitic acid and unreacted tripalmitin. Thus, optimal parameters for continuous lipase hydrolysis of tripalmitin require: enough enzyme moisture to compensate for complete substrate hydrolysis; sufficient enzyme moisture for losses due to water solubility in SC‐CO 2 ; temperature and pressure sufficient to solubilize the tripalmitin; high carbon dioxide total flow to solubilize all the tripalmitin; and a relatively large enzyme bed volume to increase the solubilized substrate contact time with the enzyme.
Sialic acid binding immunoglobulin‐like lectins may regulate innate immune responses by modulating the life span of granulocytes (2006)

The regulation of cell death is a key element in building up and maintaining both innate and adaptive immunity. A critical role in this process plays the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor family of death receptors. Recent work suggests that sialic acid binding immunoglobulin (Ig) -like lectins (Siglecs) are also empowered to transmit death signals, at least into myeloid cells. Strikingly, death induction by Siglecs is enhanced when cells are exposed to proinflammatory survival cytokines. Based on these recent insights, we hypothesize that at least some members of the Siglec family regulate immune responses via the activation of caspase-dependent and caspase-independent cell death pathways.
Synthesis and physical and physiological properties of 4'-thioRNA: application to post-modification of RNA aptamer toward NF- B (2004)

We report herein full details of the preparation of 4'-thiouridine, -cytidine, -adenosine and -guanosine phosphoramidites based on our synthetic protocol via the Pummerer reaction. Fully modified 4'-thioRNAs containing four kinds of 4'-thioribonucleoside units were prepared according to the standard RNA synthesis. The T(m) values and thermodynamic parameters of a series of duplexes were determined by UV melting and differential scanning calorimetry (DSC) measurements. The resulting overall order of thermal stabilities for the duplexes was 4'-thioRNA:4'-thioRNA >> 4'-thioRNA:RNA > RNA:RNA > RNA:DNA > 4'-thioRNA:DNA. In addition, it was shown that the dominant factor in the stability of the duplexes consisting of 4'-thioRNA was enthalpic in character. The CD spectra of not only 4'-thioRNA:RNA and 4'-thioRNA:4'-thioRNA but also 4'-thioRNA:DNA were all similar to those of duplexes in the A-conformation. The stability of 4'-thioRNA in human serum was 600 times greater than that of natural RNA. Neither the RNA:RNA nor the 4'-thioRNA:4'-thioRNA duplexes were digested under the same conditions. The first example of a post-modification of an RNA aptamer by 4'-thioribonucleoside units was demonstrated. Full modification of the aptamer thioRNA3 resulted in complete loss of binding activity. In contrast, modifications at positions other than the binding site were tolerated without loss of binding activity. The post-modified RNA aptamer thioRNA5 was thermally stabilized and resistant toward nuclease digestion. The results presented in this paper will, it is hoped, contribute to the development of 4'-thioRNA as a new generation of artificial RNA.
Replication and Transcription of Vertebrate Mitochondrial DNA (1991)

Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary ...Read More
[Granulocyte-macrophage precursor cells in umbilical cord blood]. (1986)

Authors study growth patterns of granulocytic-macrophagic progenitors in umbilical cord blood of 21 full-term newborns, using collagen gel culture method. Predominantly they obtain pure macrophagic colonies or mixed granulocytic colonies. After 7 days of incubation mean and SD of clusters in 103.22 +/- 75.88, and mean and SD of colonies is 34.26 +/- 23.1. After 14 days clusters falls down until 47.2 +/- 30.48, but colonies goes up to 74.2 +/- 32.78. Lineal regression analysis shows a correlation coefficient of 0.809 between 7 days and 14 days colonies. These results demonstrate the different behaviour between myelopoietic progenitor from umbilical cord blood and same progenitor from adult blood and are probably related to different nature of both progenitors.
A computer screening approach to immunoglobulin superfamily structures and interactions: Discovery of small non-peptidic CD4 inhibitors as novel immunotherapeutics (1997)

The interaction between CD4 and major histocompatibility complex (MHC) class II proteins is critical for the activation of CD4+ T cells, which are involved in transplantation reactions and a number of autoimmune diseases. In this study we have identified a CD4 surface pocket as a functional epitope implicated in CD4-MHC class II interaction and T-cell activation. A computer-based strategy has been used to screen approximately 150,000 non-peptidic organic compounds in a molecular data base and to identify a group of compounds as ligands of the proposed CD4 surface pocket. These small organic compounds have been shown to specifically block stable CD4-MHC class II binding, and exhibit significant inhibition of immune responses in animal models of autoimmune disease and allograft transplant rejection, suggesting their potential as novel immunosuppressants. This structure-based computer screening approach may have general implications for studying many immunoglobulin-like structures and interactions that share similar structural features. Furthermore, the results from this study have demonstrated that the rational design of small non-peptidic inhibitors of large protein-protein interfaces may indeed be an achievable goal.
The monoclonal gammopathies (1994)

Each monoclonal protein (M-protein, or myeloma protein) consists of two heavy polypeptide chains of the same class and subclass and two light polypeptide chains of the same type. Electrophoresis on cellulose acetate membranes is satisfactory for screening, although agarose electrophoresis is more sensitive for detecting small M-proteins. Immunoelectrophoresis should be performed when myeloma, macroglobulinemia, amyloidosis, or a related disorder is suspected. Immunofixation is useful when results of immunoelectrophoresis are equivocal. The recognition of a Bence Jones protein depends on the demonstration of a monoclonal light chain by immunoelectrophoresis or immunofixation of an adequately concentrated urine specimen. The differential diagnosis of an M-protein includes monoclonal gammopathy of undetermined significance (benign monoclonal gammopathy), multiple myeloma, solitary plasmacytoma of bone or extramedullary plasmacytoma, macroglobulinemia, lymphoma, chronic lymphocytic leukemia, and primary systemic amyloidosis.
An Introduction to Light Interaction with Human Skin (2004)

Despite the notable progress in physically-based rendering, there is still a long way to go before one can automatically generate predictable images of organic materials such as human skin. In this tutorial, the main physical and biological aspects involved in the processes of propagation and absorption of light by skin tissues are examined. These processes affect not only skin appearance, but also its health. For this reason, they have also been the object of study in biomedical research. The models of light interaction with human skin developed by the biomedical community are mainly aimed at the simulation of skin spectral properties which are used to determine the concentration and distribution of various substances. In computer graphics, the focus has been on the simulation of light scattering properties that affect skin appearance. Computer models used to simulate these spectral and scattering properties are described in this tutorial, and their strengths and limitations discussed. Keywords: natural phenomena, biologically and physically-based rendering.
Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing (2012)

Mint adaptor proteins bind to the amyloid precursor protein (APP) and regulate APP processing associated with Alzheimer's disease; however, the molecular mechanisms underlying Mint regulation in APP binding and processing remain unclear. Biochemical, biophysical, and cellular experiments now show that the Mint1 phosphotyrosine binding (PTB) domain that binds to APP is intramolecularly inhibited by the adjacent C-terminal linker region. The crystal structure of a C-terminally extended Mint1 PTB fragment reveals that the linker region forms a short α-helix that folds back onto the PTB domain and sterically hinders APP binding. This intramolecular interaction is disrupted by mutation of Tyr633 within the Mint1 autoinhibitory helix leading to enhanced APP binding and β-amyloid production. Our findings suggest that an autoinhibitory mechanism in Mint1 is important for regulating APP processing and may provide novel therapies for Alzheimer's disease.
Elementary gates for quantum computation (1995)

We show that a set of gates that consists of all one-bit quantum gates [U(2)] and the two-bit exclusive-OR gate [that maps Boolean values (x,y) to (x,x\ensuremath{\bigoplus}y)] is universal in the sense that all unitary operations on arbitrarily many bits n [U(${2}^{\mathit{n}}$)] can be expressed as compositions of these gates. We investigate the number of the above gates required to implement other gates, such as generalized Deutsch-Toffoli gates, that apply a specific U(2) transformation to one input bit if and only if the logical and of all remaining input bits is satisfied. These gates play a central role in many proposed constructions of quantum computational networks. We derive upper and lower bounds on the exact number of elementary gates required to build up a variety of two- and three-bit quantum gates, the asymptotic number required for n-bit Deutsch-Toffoli gates, and make some observations about the number required for arbitrary n-bit unitary operations.
Efficient Aldolase Catalytic Antibodies That Use the Enamine Mechanism of Natural Enzymes (1995)

Antibodies that catalyze the aldol reaction, a basic carbon-carbon bond-forming reaction, have been generated. The mechanism for antibody catalysis of this reaction mimics that used by natural class I aldolase enzymes. Immunization with a reactive compound covalently trapped a Lys residue in the binding pocket of the antibody by formation of a stable vinylogous amide. The reaction mechanism for the formation of the covalent antibody-hapten complex was recruited to catalyze the aldol reaction. The antibodies use the ε-amino group of Lys to form an enamine with ketone substrates and use this enamine as a nascent carbon nucleophile to attack the second substrate, an aldehyde, to form a new carbon-carbon bond. The antibodies control the diastereofacial selectivity of the reaction in both Cram-Felkin and anti-Cram-Felkin directions.
Religious and Political Liberalism among Catholics (1967)

This study treats the social correlates of religious liberalism and the relation between religious and political liberalism among students at a Catholic University. Concerning the first question it was found that religious liberals tend to have the attributes of central and elite members of the Catholic college community. Concerning the second it was found that, while religious and political liberalism are related, the relationship is strongest among the priests and nuns in the sample and relatively weak among the lay students. It is only in matters of civil rights and civil liberties that a fairly strong correlation between the two liberalisms appears among the laity as well as priests and nuns.
Electromagnetic band-gap structures for multiband mitigation of resonant modes in parallel-plate waveguides (2004)

A novel electromagnetic band-gap structure (EBG), whose surface impedance is primarily controlled by its inductance per unit area, is presented. This EBG, which exhibits two wide forbidden band-gaps at very low frequencies, is applied to mitigating resonant modes in parallel-plate waveguides. It is shown that the two forbidden band-gaps can either be controlled independently by varying the physical separation between adjacent patches or simultaneously by varying the number of turns of the spiral inductor used in the patch of the unit cell.
ChemInform Abstract: Natural Products to Drugs: Natural Product Derived Compounds in Clinical Trials (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.