gebhart/patrepeval huggingface dataset:
Towards Modal Integration of Overhead and Underground Low-Voltage and Medium-Voltage Power Line Communication Channels in the Smart Grid Landscape: Model Expansion, Broadband Signal Transmission Characteristics, and Statistical Performance Metrics (Invited Paper) (2012)

The established statistical analysis, already used to treat overhead transmission power grid networks, is now implemented to examine the factors influencing modal transmission characteristics and modal statistical performance metrics of overhead and underground low-voltage/broadband over power lines (LV/BPL) and medium-voltage/broadband over power lines (MV/BPL) channels associated with power distribution in smart grid (SG) networks. The novelty of this paper is threefold. First, a refined multidimensional chain scattering matrix (TM2) method suitable for overhead and underground LV/BPL and MV/BPL modal channels is evaluated against other relative theoretical and experimental proven models. Second, applying TM2 method, the end-to-end modal channel attenuation of various LV/BPL and MV/BPL multiconductor transmission line (MTL) configurations is determined. The LV/BPL and MV/BPL transmission channels are investigated with regard to their spectral behavior and their end-to-end modal channel attenuation. It is found that the above features depend drastically on the frequency, the type of power grid, the mode considered, the MTL configuration, the physical properties of the cables used, the end-to-end distance, and the number, the electrical length, and the terminations of the branches encountered along the end-to-end BPL signal propagation. Third, the statistical properties of various overhead and underground LV/BPL and MV/BPL modal channels are investigated revealing the correlation between end-to-end modal channel attenuation and modal root-mean-square delay spread (RMS-DS). Already verified in the case of overhead high-voltage (HV) BPL systems, this fundamental property of several wireline systems is also modally validated against relevant sets of field measurements, numerical results, and recently proposed statistical channel models for various overhead and underground LV/BPL and MV/BPL channels. Based on this common inherent attribute of either transmission or distribution BPL networks, new unified regression trend line is proposed giving a further boost towards BPL system intraoperability. A consequence of this paper is that it aids in gaining a better understanding of the range and coverage that BPL solutions can achieve; a preliminary step toward the system symbiosis between BPL systems and other broadband technologies in an SG environment.
Cell Division Rates of Primary Human Precursor B Cells in Culture Reflect In Vivo Rates (2004)

Bone marrow stroma-based cultures provide a powerful model for studying cell division and apoptosis of primary human precursor B cells. Studies using this model are elucidating the mechanisms by which stromal cells inhibit apoptosis of cultured normal precursor B cells and have demonstrated that the apoptotic rate of cultured leukemic precursor B cells can predict clinical outcome in acute lymphoblastic leukemia. In contrast to apoptosis, cell division in this model has not been well characterized. In this study, we quantified the rates of cell division in cultured primary human normal and leukemic precursor B cells by labeling precursor B cells with the fluorescent dye carboxyfluorescein diacetate, succinimyl ester. Based on the rate of decreasing fluorescent signal over 3 weeks, normal CD19(+), CD10(+) precursor B cells divided once every 90.5 hours, a number that correlates well with the known in vivo rate of 65.5 hours. The division rates were similar among different cultures and constant throughout the 3 weeks of culture, suggesting that the variable expansions of precursor B cells seen among different samples and culture durations are not secondary to different cell division rates. Unlike normal cells, cultured leukemic B cells had a heterogeneous division rate that ranged from once every 26-240 hours. These rates correlated well with their respective in vivo proliferation index. These findings indicate that the stroma-based cultures faithfully replicate in vivo cell division rates and can be used to elucidate the pathways that regulate cell division of primary human precursor B cells.
The Jβ segment of the T cell receptor contributes to the Vβ‐specific T cell expansion caused by staphylococcal enterotoxin B and Urtica dioica superantigens (1996)

We have used a new polymerase chain reaction-based technique to analyze at the clonal level the CDR3 diversity and the J beta usage associated with the V beta-dependent T cell receptor (TCR) recognition of two superantigens: the staphylococcal enterotoxin B and the Urtica dioica agglutinin. Our results show that subset of J beta elements is preferentially expanded in a given V beta family, independently of the nature of the superantigen. By contrast, the CDR3 loop does not contribute significantly to the T cell expansion induced by the superantigens. We conclude that the J beta segment of the TCR beta chain, but not the CDR3 region, participates in superantigen binding, presumably by influencing the quaternary structure of the TCR beta chain.
Near-Optimal Worst-Case Throughput Routing for Two-Dimensional Mesh Networks (2005)

Minimizing latency and maximizing throughput are important goals in the design of routing algorithms for interconnection networks. Ideally, we would like a routing algorithm to (a) route packets using the minimal number of hops to reduce latency and preserve communication locality, (b) deliver good worst-case and average-case throughput and (c) enable low-complexity (and hence, low latency) router implementation. In this paper, we focus on routing algorithms for an important class of interconnection networks: two dimensional (2D) mesh networks. Existing routing algorithms for mesh networks fail to satisfy one or more of design goals mentioned above. Variously, the routing algorithms suffer from poor worst case throughput (ROMM [13], DOR [23]), poor latency due to increased packet hops (VALIANT [31]) or increased latency due to hardware complexity (minimaladaptive [7, 30]). The major contribution of this paper is the design of an oblivious routing algorithm - O1TURN - with provable near-optimal worst-case throughput, good average-case throughput, low design complexity and minimal number of network hops for 2D-mesh networks, thus satisfying all the stated design goals. O1TURN offers optimal worst-case throughput when the network radix (k in a kxk network) is even. When the network radix is odd, O1TURN is within a 1/k2 factor of optimal worst-case throughput. O1TURN achieves superior or comparable average-case throughput with global traffic as well as local traffic. For example, O1TURN achieves 18.8%, 0.7% and 13.6% higher average-case throughput than DOR, ROMM and VALIANT routing, respectively when averaged over one million random traffic patterns on an 8x8 network. Finally, we demonstrate that O1TURN is well suited for a partitioned router implementation that is of similar delay complexity as a simple dimension-ordered router. Our implementation incurs a marginal increase in switch arbitration delay that is completely hidden in pipelined routers as it is not on the clock-critical path.
A low-power analog sampled-data VLSI architecture for equalization and FDTS/DF detection (1995)

The design philosophy behind a low-power integrated circuit architecture for implementing an FDTS/DF magnetic recording channel is presented. The goal of this philosophy is to achieve high clock speed, moderate power consumption, and relatively small die area. The principle components that are considered are a programmable FIR sampled-data analog equalizer and an analog sampled-data FDTS/DF detector. These blocks are implemented using sampled-data analog signal processing circuitry to avoid the need for a high-speed high-power analog-to-digital converter. Novel features of the FIR equalizer architecture include sampling of current rather than voltage, which allows extremely high sampling bandwidth; and, analog multiplication using MOS devices in their linear region which achieves a power dissipation on the order of 5 mW/tap at 100 MS/s.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Diet and Estrogen Status: The Cruciferous Connection (1998)

Cruciferous vegetables, such as cabbage, cauliflower, and broccoli, have been cultivated since antiquity as medicinal plants. Once ingested, the Cruciferae release unique phytochemical constituents able to modify the activity of cellular enzymes effecting carcinogen clearance and estrogen metabolism. The most active of these phytochemicals with regard to estrogen is the dietary indole, diindolylmethane. Understanding the dietary influences of cruciferous phytochemicals on estrogen status provides a basis for nutritional approaches to estrogen-related concerns that accompany aging in women and men.
Biosynthesis of Poly[(R)-3-hydroxyalkanoate] Copolymers with Controlled Repeating Unit Compositions and Physical Properties (2012)

As applications for biodegradable and biologically produced poly[(R)-3-hydroxyalkanoates] (PHAs) grow into more specialized areas, the need to precisely control the repeating unit composition and consequently the physical properties of these polymers has become essential. A previous study reported our development of Escherichia coli LSBJ in order to produce PHA polymers composed of single repeating units ranging from 4 to 12 carbon atoms. This investigation expands the scope of our effort toward controlling the repeating unit composition of a variety of PHA copolymers. The sizes for the repeating units within the copolymers were modulated by feeding specific ratios of fatty acids with defined carbon lengths to E. coli LSBJ, which resulted in defined mole ratios for the repeating units. Various physical properties of the copolymers (including the Young's modulus, elongation to break, and glass-transition temperature) were shown to be strongly dependent upon the mole ratios of repeating units. This work demonstrates that copolymers of PHAs with repeating units from 4 to 12 carbons can be incorporated accurately to obtain any desired mole ratio within the PHA copolymers. Our methodology may thus be extended to generate tailor-made PHA copolymers with prescribed values for key sets of physical properties.
Comparison of induced resistance activated by benzothiadiazole, (2R,3R)‐butanediol and an isoparaffin mixture against anthracnose of Nicotiana benthamiana (2010)

Resistance in Nicotiana benthamiana against anthracnose caused by the hemibiotrophic fungus Colletotrichum orbiculare was activated by benzothiadiazole (BTH), (2R,3R)­butanediol or PC1, an isoparaffin‐based mixture. In inoculation experiments, BTH, (2R,3R)­butanediol and PC1 reduced the number of lesions per leaf area caused by C . orbiculare by 98%, 77% and 81%, respectively. Foliar application of BTH induced expression of genes for the acidic pathogenesis‐related (PR) proteins, NbPR‐1a , NbPR‐ 3 Q and acidic NbPR‐ 5. In contrast, soil application of (2R,3R)­butanediol or PC1 primed expression of genes for the basic PR proteins, NbPRb‐1b , basic NbPR‐2 and NbPR‐5dB . These results are consistent with the activation of salicylic‐acid‐dependent systemic acquired resistance (SAR) by BTH and that of jasmonate/ethylene‐dependent induced systemic resistance (ISR) by (2R,3R)­butanediol or PC1, and show that (2R,3R)­butanediol and PC1 can affect gene expression similarly to plant growth‐promoting rhizobacteria. However, the effects of (2R,3R)‐butanediol and PC1 were not identical. In addition to priming, (2R,3R)‐butanediol induced expression of basic NbPR‐2 , whereas PC1 treatment induced expression of both NbPRb‐1b and basic NbPR‐2 . Although a number of microbial products, such as (2R,3R)­butanediol, have been shown to produce ISR, this is the first demonstration that an isoparaffin‐based mixture, not derived from a microorganism, can produce ISR.
Near-Edge X-Ray Absorption Fine-Structure Investigation of Graphene (2008)

We report the near-edge x-ray absorption fine-structure (NEXAFS) spectrum of a single layer of graphite (graphene) obtained by micromechanical cleavage of highly ordered pyrolytic graphite on a ${\mathrm{SiO}}_{2}$ substrate. We utilized a photoemission electron microscope to separately study single-, double-, and few-layers graphene samples. In single-layer graphene we observe a splitting of the ${\ensuremath{\pi}}^{*}$ resonance and a clear signature of the predicted interlayer state. The NEXAFS data illustrate the rapid evolution of the electronic structure with the increased number of layers.
The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study (2009)

Energy metabolism in the human brain is not fully understood. Classically, glucose is regarded as the major energy substrate. However, lactate (conventionally a product of anaerobic metabolism) has been proposed to act as an energy source, yet whether this occurs in man is not known. Here we show that the human brain can indeed utilize lactate as an energy source via the tricarboxylic acid cycle. We used a novel combination of (13)C-labelled cerebral microdialysis both to deliver (13)C substrates into the brain and recover (13)C metabolites from the brain, and high-resolution (13)C nuclear magnetic resonance. Microdialysis catheters were placed in the vicinity of focal lesions and in relatively less injured regions of brain, in patients with traumatic brain injury. Infusion with 2-(13)C-acetate or 3-(13)C-lactate produced (13)C signals for glutamine C4, C3 and C2, indicating tricarboxylic acid cycle operation followed by conversion of glutamate to glutamine. This is the first direct demonstration of brain utilization of lactate as an energy source in humans.
Principles for designing proteins with cavities formed by curved β sheets (2017)

Active sites and ligand-binding cavities in native proteins are often formed by curved β sheets, and the ability to control β-sheet curvature would allow design of binding proteins with cavities customized to specific ligands. Toward this end, we investigated the mechanisms controlling β-sheet curvature by studying the geometry of β sheets in naturally occurring protein structures and folding simulations. The principles emerging from this analysis were used to design, de novo, a series of proteins with curved β sheets topped with α helices. Nuclear magnetic resonance and crystal structures of the designs closely match the computational models, showing that β-sheet curvature can be controlled with atomic-level accuracy. Our approach enables the design of proteins with cavities and provides a route to custom design ligand-binding and catalytic sites.
Disulfide Folding Pathways of Cystine Knot Proteins (2003)

The plant cyclotides are a fascinating family of circular proteins that contain a cyclic cystine knot motif. The knotted topology and cyclic nature of the cyclotides pose interesting questions about folding mechanisms and how the knotted arrangement of disulfide bonds is formed. In the current study we have examined the oxidative refolding and reductive unfolding of the prototypic cyclotide, kalata B1. A stable two-disulfide intermediate accumulated during oxidative refolding but not in reductive unfolding. Mass spectrometry and NMR spectroscopy were used to show that the intermediate contained a native-like structure with two native disulfide bonds topologically similar to the intermediate isolated for the related cystine knot protein EETI-II (Le-Nguyen, D., Heitz, A., Chiche, L., El Hajji, M., and Castro B. (1993) Protein Sci. 2, 165-174). However, the folding intermediate observed for kalata B1 is not the immediate precursor of the three-disulfide native peptide and does not accumulate in the reductive unfolding process, in contrast to the intermediate observed for EETI-II. These alternative pathways of linear and cyclic cystine knot proteins appear to be related to the constraints imposed by the cyclic backbone of kalata B1 and the different ring size of the cystine knot. The three-dimensional structure of a synthetic version of the two-disulfide intermediate of kalata B1 in which Ala residues replace the reduced Cys residues provides a structural insight into why the two-disulfide intermediate is a kinetic trap on the folding pathway.
Tardive dyskinesia and new antipsychotics (2008)

Current evidence supports a lower tardive dyskinesia risk for second-generation antipsychotics than for first-generation antipsychotics. Tardive dyskinesia incidence was higher with second-generation antipsychotics than previously reported, possibly due to recent studies with relatively short mean durations and use of nonstandard tardive dyskinesia definitions.
Effects of Nitrogen, Methane, and Oxygen on Structure and Electrical Properties of Thin Tantalum Films (1964)

An investigation was made of tantalum films sputtered in argon containing individual small amounts of nitrogen, methane, and oxygen. With argon alone, 1000-Å bcc tantalum films deposited on glass substrates heated to 400°C had a specific resistivity four times the bulk value, with the increase attributable to a reactive gas residual pressure of 10−6 to 10−5 Torr. The mixed argon-nitrogen experiments produced initially hcp Ta2N, and at higher pressures an fcc phase attributed to a new TaN structure. With methane only fcc TaC was obtained, while with oxygen an amorphous phase began to grow initially, and at higher pressures was dominant with a structure identical to anodically formed Ta2O5. The nitrides and carbide have specific resistivities from 200–300×10−6 Ω cm, and temperature coefficients between +3×10−4 and −2×10−4 deg−1. With increasing oxygen content, the specific resistivity increases approximately exponentially; the positive temperature coefficient decreases, becomes zero before the precipitation of Ta2O5, and then increases negatively at a rapid rate at the appearance of Ta2O5.
Moving beyond Molecules:  Patterning Solid-State Features via Dip-Pen Nanolithography with Sol-Based Inks (2002)

Herein, we described a new dip-pen nanolithography (DPN)-based method for the direct patterning of organic/inorganic composite nanostructures on silicon and oxidized silicon substrates. The approach works by the hydrolysis of metal precursors in the meniscus between an AFM tip and a surface according to the reaction 2MCln + nH2O --> M2On + 2nHCl; M = Al, Si, and Sn. The inks are hybrid composites of inorganic salts with amphiphilic block copolymer surfactants. Three proof-of-concept systems involving Al2O3, SiO2, and SnO2 nanostructures on silicon and silicon oxide surfaces have been studied. Arrays of dots and lines can be written easily with control over feature size and shape on the sub-200 nm level. The structures have been characterized by atomic force microscopy, scanning electron microscopy, transmission electron microscopy, and energy-dispersive X-ray analysis. This work is important because it opens up the opportunity for using DPN to deposit solid-state materials rather than simple organic molecules onto surfaces with the resolution of an AFM without the need for a driving force other than chemisorption (e.g., applied fields).
Efficacy of a Dengue Vaccine Candidate (TAK-003) in Healthy Children and Adolescents 2 Years after Vaccination (2020)

TAK-003 demonstrated continued benefit independent of baseline serostatus in reducing dengue with some decline in efficacy during the second year. Three-year data will be important to see if efficacy stabilizes or declines further.Clinical Trials Registration. NCT02747927.Takeda's tetravalent dengue vaccine (TAK-003) continued to demonstrate benefit in reducing dengue independent of baseline serostatus up to 2 years after completing vaccination with some decline in efficacy during the second year in 4-16 year olds in dengue-endemic countries.
Effects of antiepidermal growth factor receptor antibody 528 on the proliferation and differentiation of head and neck cancer (1994)

Antibodies directed against the epidermal growth factor receptor may impede proliferation and induce differentiation of head and neck squamous cell carcinoma. To test this hypothesis, we examined the effect of monoclonal antibody 528 directed against epidermal growth factor receptor on the proliferation and differentiation of monolayer cells and multicenter tumor spheroids from three head and neck squamous cell carcinoma cell lines (1483, MDA 686Ln, and MDA 886Ln) and the epidermal growth factor-responsive vulvar carcinoma A431. All head and neck squamous cell carcinoma lines were shown to express high levels of epidermal growth factor receptor by Scatchard analyses. Epidermal growth factor inhibited the growth of monolayer cells but stimulated the growth of 886 and A431 multicellular tumor spheroids. Epidermal growth factor modulated the differentiation of A431 and 686 with respect to involucrin immunohistochemistry and cornified enveloped competency. Monoclonal antibody 528 directed against epidermal growth factor receptor inhibited cellular proliferation as measured by cell number, thymidine incorporation, and multicellular tumor spheroid volume. A mild promotion of differentiation was observed in the epidermal growth factor-responsive cells. In conclusion, monoclonal antibody 528 directed against epidermal growth factor receptor inhibits growth of head and neck squamous cell carcinoma cells bearing high levels of epidermal growth factor receptors and promotes differentiation in some tumors. The use of a multicellular tumor spheroid model to evaluate growth factor responsiveness and inhibition of proliferation may more accurately reflect in vivo tumor growth than monolayer cells. Antibodies against epidermal growth factor receptor may prove effective in modulating disease progression in patients with head and neck squamous cell carcinoma.
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells (2003)

Although the existence of mammary stem cells has been suggested by serial transplantation studies in mice, their identification has been hindered by the lack of specific surface markers, and by the absence of suitable in vitro assays for testing stem cell properties: self-renewal and ability to generate differentiated progeny. We have developed an in vitro cultivation system that allows for propagation of human mammary epithelial cells (HMECs) in an undifferentiated state, based on their ability to proliferate in suspension, as nonadherent mammospheres. We demonstrate that nonadherent mammospheres are enriched in early progenitor/stem cells and able to differentiate along all three mammary epithelial lineages and to clonally generate complex functional structures in reconstituted 3D culture systems. Gene expression analysis of cells isolated from nonadherent mammospheres revealed overlapping genetic programs with other stem and progenitor cells and identified new markers that may be useful in the identification of mammary stem cells. The isolation and characterization of these stem cells should help elucidate the molecular pathways that govern normal mammary development and carcinogenesis.