gebhart/patrepeval huggingface dataset:
Pulsed laser desorption with resonant two-photon ionization detection in supersonic beam mass spectrometry (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPulsed laser desorption with resonant two-photon ionization detection in supersonic beam mass spectrometryRoger. Tembreull and David M. LubmanCite this: Anal. Chem. 1986, 58, 7, 1299–1303Publication Date (Print):June 1, 1986Publication History Published online1 May 2002Published inissue 1 June 1986https://pubs.acs.org/doi/10.1021/ac00298a007https://doi.org/10.1021/ac00298a007research-articleACS PublicationsRequest reuse permissionsArticle Views248Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Stimulation of endothelial angiotensin-converting enzyme by morphine via non-opioid receptor mediated processes. (1998)

In this study, we examined the influence of morphine and naloxone on the enzymatic activity of different ecto-peptidases located on the surface of endothelial cells. Morphine increased in a concentration dependent manner the degradation of Leu-enkephalin in cultivated bovine aortic endothelial cells. Naloxone, a morphine antagonist, did not prevent this effect, but caused it as well. The enhanced Leu-enkephalin degradation was due to an increase in the activity of angiotensin-converting enzyme (ACE), whereas the activity of other ecto-peptidases (aminopeptidase N and neutral endopeptidase) was not influenced. Despite a high non-specific binding of [3H]-morphine, no specific opioid receptor binding on the endothelial cells could be detected. Autoradiographic investigations with native, cryostat-sectioned cells demonstrated that [3H]-morphine was nearly exclusively located within the nuclei. The present results suggests that the morphine effect concerning ACE activity is not mediated via opioid receptors but presumably by interactions within the cell nucleus.
Rebirth of the Phase Comparison Line Protection Principle (2006)

This paper presents a standard pilot phase comparison protective relaying scheme for transmission lines. It offers excellent sensitivity, very fast tripping, immunity to power swings, effective protection for long or short lines, and reduced need for setting calculations and settings maintenance. The performance is superior to that of pilot distance or directional comparison schemes. The proposed scheme meets the technical and management demands for protective relaying satisfying more stringent system security requirements.
Rizatriptan Vs. Rizatriptan Plus Trimebutine for the Acute Treatment of Migraine: A Double-Blind, Randomized, Cross-Over, Placebo-Controlled Study (2006)

Gastroparesis frequently happens during migraine attacks, postponing the onset of action of orally administered drugs. Furthermore, triptans seem to work better in the earlier phases of the migraine attacks. Therefore, associating a gastrokinetic drug with a triptan may translate into better efficacy and higher consistency of response. Trimebutine is an opioid derivative with exclusive action on receptors of the Meissner and Auerbach plexus throughout the digestive tube. It has no absorption or central penetration. Herein we contrast the combination of rizatriptan plus trimebutine with rizatriptan alone in the acute treatment of migraine. Forty patients with migraine consecutively seen in our clinic were randomized to treat two consecutive moderate or severe attacks with one tablet of 10 mg rizatriptan plus one capsule of 200 mg trimebutine and two attacks with the same triptan and placebo, in counterbalanced order. We collected information on the severity of the attack, as well as presence of nausea and photophobia at the time of drug intake, and after 1, 2 and 4 h. Recurrence and adverse events were also contrasted. Sixty-four attacks were treated with each drug regimen. At 1 h postdose, 30 (46.8%) of 64 attacks treated with the combination resolved completely, vs. eight (12.5%) of the rizatriptan-treated attacks, a difference of 34% (P < 0.01). At 2 h postdose, 47 (73.4%) attacks treated with the combination vs. 20 (31.2%) of those treated with rizatriptan alone resolved completely, a difference of 42% (95% confidence interval 26, 58, P < 0.001). Regarding nausea and photophobia, the combination was also associated with significantly better response. Recurrence was similar among the two drug regimens, as well as adverse events. The combination rizatriptan and trimebutine is more effective than rizatriptan alone. The combination does not increase adverse events or recurrence of pain.
A bispecific protein rG7S-MICA recruits natural killer cells and enhances NKG2D-mediated immunosurveillance against hepatocellular carcinoma (2016)

MHC class I-related chain A (MICA) is a principal immunoligand of the natural killer (NK) cell receptor NK group 2, member D (NKG2D) and plays a key role in NK cell-mediated immune recognition. Shedding of MICA from tumor cells leads to immunosuppression. To reconstitute the immunosurveilance function of NK cells, we constructed a fusion protein rG7S-MICA and explored its potential anti-tumor activity against hepatocellular carcinoma (HCC). rG7S-MICA consists of human MICA and a single-chain antibody fragment (scFv) targeting the tumor-associated antigen cluster of differentiation 24 (CD24). In vitro, rG7S-MICA engaged both NK cells and CD24(+) human HCC cells, and triggered NK cell-mediated cytolysis. Furthermore, in CD24(+) HCC-bearing nude mice, rG7S-MICA specifically targeted to the tumor tissue, where it effectively recruited NK cells and induced the release of cytokines, and showed superior anti-tumor activity. In conclusion, rG7S-MICA provides a new approach for HCC-targeting immunotherapy and has attracting potentials for clinical applications.
One step preparation of both human C‐reactive protein and CIt (1978)

Traditional information systems struggle with the requirement to provide flexibility and process support while still enforcing some degree of control. Accordingly, adaptive Process Management Systems (PMSs) have emerged that provide some flexibility by enabling dynamic process changes during runtime. Based on the assumption that these process changes are recorded explicitly, we present two techniques for mining change logs in adaptive PMSs; that is, we do not only analyse the execution logs of the operational processes, but also consider the adaptations made at the process instance level. The change processes discovered through process mining provide an aggregated overview of all changes that happened so far. Using process mining as an analysis tool we show in this paper how better support can be provided for truly flexible processes by understanding when and why process changes become necessary.
Epithelial cancer cell migration: a role for chemokine receptors? (2001)

We investigated the possibility that chemokine gradients influence migration of human ovarian epithelial tumor cells. Of 14 chemokine receptors investigated, only CXCR4 was expressed on ovarian cancer cells. CXCR4 mRNA localized to a subpopulation of tumor cells in ovarian cancer biopsies. Ovarian cancer cell lines and cells freshly isolated from ascites expressed CXCR4 protein. The CXCR4 ligand, CXCL12, was found in ascites from 63 patients. CXCL12 elicited intracellular calcium flux and directed migration and changes in integrin expression in ovarian cancer cells. CXCR4 may influence cell migration in the peritoneum, a major route for ovarian cancer spread, and could be a therapeutic target.
Built-In Testing of Memory Using an On-Chip Compact Testing Scheme (1986)

In this paper we study the problem of testing RAM. A new fault model, which encompasses the existing fault models, is proposed. We then propose a scheme of testing faults from the new fault model using built-in testing techniques. We introduce concept of p-hard and determine the complexity of the extra hardware required for built-in self-testing on our hardness scale. A novel approach using microcoded ROM for implementation of built-in testing is also proposed and its complexity is determined.
Heterojunction bipolar transistors using Si-Ge alloys (1989)

Advanced epitaxial growth techniques permit the use of pseudomorphic Si/sub 1-x/Ge/sub x/ alloys in silicon technology. The smaller bandgap of these alloys allows for a variety of novel band-engineered structures that promise to enhance silicon-based technology significantly. The authors discuss the growth and properties of pseudomorphic Si/sub 1-x/Ge/sub x/ structures and then focus on their applications, especially the Si/sub 1-x/Ge/sub x/-base heterojunction bipolar transistor (HBT). They show that HBTs in the Si/sub 1-x/Ge/sub x/ system allow for the decoupling of current gain and intrinsic base resistance. Such devices can be made by using a variety of techniques, including molecular-beam epitaxy and chemical vapor deposition. The authors describe the evolution of fabrication schemes for such HBTs and describe the DC and AC results obtained. They show that optimally designed HBTs coupled with advanced bipolar structures can provide performance leverage.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
EphA2 overexpression causes tumorigenesis of mammary epithelial cells. (2001)

Elevated levels of protein tyrosine phosphorylation contribute to a malignant phenotype, although the tyrosine kinases that are responsible for this signaling remain largely unknown. Here we report increased levels of the EphA2 (ECK) protein tyrosine kinase in clinical specimens and cell models of breast cancer. We also show that EphA2 overexpression is sufficient to confer malignant transformation and tumorigenic potential on nontransformed (MCF-10A) mammary epithelial cells. The transforming capacity of EphA2 is related to the failure of EphA2 to interact with its cell-attached ligands. Interestingly, stimulation of EphA2 reverses the malignant growth and invasiveness of EphA2-transformed cells. Taken together, these results identify EphA2 as a powerful oncoprotein in breast cancer.
Inkjet Deposition of Layer-by-Layer Assembled Films (2010)

Layer-by-layer assembly (LBL) can create advanced composites with exceptional properties unavailable by other means, but the laborious deposition process and multiple dipping cycles hamper their utilization in microtechnologies and electronics. Multiple rinse steps provide both structural control and thermodynamic stability to LBL multilayers, but they significantly limit their practical applications and contribute significantly to the processing time and waste. Here we demonstrate that by employing inkjet technology one can deliver the necessary quantities of LBL components required for film buildup without excess, eliminating the need for repetitive rinsing steps. This feature differentiates this approach from all other recognized LBL modalities. Using a model system of negatively charged gold nanoparticles and positively charged poly(diallyldimethylammonium) chloride, the material stability, nanoscale control over thickness, and particle coverage offered by the inkjet LBL technique are shown to be equal or better than the case of multilayers made with traditional dipping cycles. The opportunity for fast deposition of complex metallic patterns using a simple inkjet printer is also shown. The additive nature of LBL deposition based on the formation of insoluble nanoparticle-polyelectrolyte complexes of various compositions provides an excellent opportunity for versatile, multicomponent, and noncontact patterning for the simple production of stratified patterns that are much needed in advanced devices.
An integrated free space optical bus (2003)

As integrated circuit linewidths are reduced, single-chip system functionality and speed increase. Conventional electronic chip input/output does not follow this trend: bonding pad sizes and off chip capacitive loads remain essentially constant. Shortage of chip interconnect capability has become critical. Integrated free-space optical interconnect has the potential to overcome this problem by providing a large number of high-speed connections between chips. A description is given of the application of free-space optics, quantum-well modulators, and CMOS photodetectors to this task.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Efficient Dynamic Provable Possession of Remote Data via Update Trees. (2012)

The emergence and wide availability of remote storage service providers prompted work in the security community that allows a client to verify integrity and availability of the data that she outsourced to an untrusted remove storage server at a relatively low cost. Most recent solutions to this problem allow the client to read and update (i.e., insert, modify, or delete) stored data blocks while trying to lower the overhead associated with verifying the integrity of the stored data. In this work we develop a novel scheme, performance of which favorably compares with the existing solutions. Our solution enjoys a number of new features such as a natural support for operations on ranges of blocks, revision control, and support for multiple user access to shared content. The performance guarantees that we achieve stem from a novel data structure termed a balanced update tree and removing the need to verify update operations. 1
Multimedia Clip Generation From Documents for Browsing on Mobile Devices (2008)

Small displays on mobile handheld devices, such as personal digital assistants (PDAs) and cellular phones, are the bottlenecks for usability of most content browsing applications. Generally, conventional content such as documents and Web pages need to be modified for effective presentation on mobile devices. This paper proposes a novel visualization for documents, called multimedia thumbnails, which consists of text and image content converted into playable multimedia clips. A multimedia thumbnail utilizes visual and audio channels of small portable devices as well as both spatial and time dimensions to communicate text and image information of a single document. The proposed algorithm for generating multimedia thumbnails includes 1) a semantic document analysis step, where salient content from a source document is extracted; 2) an optimization step, where a subset of this extracted content is selected based on time, display, and application constraints; and 3) a composition step, where the selected visual and audible document content is combined into a multimedia thumbnail. Scalability of MMNails that allows generation of multimedia clips of various lengths is also described. A user study is presented that evaluates the effectiveness of the proposed multimedia thumbnail visualization.
Depth distributions of sulfur implanted into silicon as a function of ion energy, ion fluence, and anneal temperature (1984)

Depth distributions for sulfur (S) implanted in (100) and (111) silicon (Si) measured by secondary ion mass spectrometry are reported for S ion energies from 40 to 600 keV and ion fluences from 4×1012 to 4×1016 cm−2. The results of Pearson IV fits are tabulated for the energy and fluence series; the range parameters given are peak depth (Rm) and μ(Rp), σ(ΔRp), γ1, β2, and β′2 for both the peak of the distribution and the full curve (including the influence of the channeling tail). The S densities are measured from a maximum of 1021 down to &amp;lt;1015 cm−3 where the detection limit is probably caused by background oxygen (mass 32). Sulfur profiles are shown for annealing temperatures from 100 to 950 °C in (100) and (111) Si orientations. Sulfur is retained in the region of damage for densities above about 1018 cm−3, until an annealing temperature of 900 or 950 °C is reached, when the S is largely rejected from the Si crystal; the remaining S density is &amp;lt;1015 cm−3, in agreement with solid solubility.
Prevalence, genotypes, and an isolate (HC‐C2) of hepatitis C virus in Chinese patients with liver disease (1993)

China has not been extensively investigated for the prevalence of hepatitis C virus (HCV) infection among people with or without liver disease. We analyzed serum from 2,177 liver disease patients from 7 cities in different areas of China. Of 435 acute hepatitis patients, only 11% were positive for HCV RNA, while hepatitis B surface antigen (HBsAg) was detected in 33%. Of 1,668 patients with chronic liver disease, 14% and 74% were positive for HCV RNA and HBsAg, respectively. Nearly 80% of non-B chronic liver disease were negative for HCV RNA. The frequency of HCV RNA in chronic liver disease was significantly higher in Hami (32%) and Shenyang (30%) than in other cities (6-12%). The HCV genotype distribution varied by region. Genotype III was detected in 46-70% of HCV infections in Hami, Shenyang, and Lanzhou, while more than 90% of patients from southern cities (Nanjing, Nanning, and Chengdu) had genotype II. No evidence for genotype I or IV infections was found. A full-length HCV genome sequence (HC-C2) derived from a Beijing patient with genotype II was closely related to previous isolates from Japanese and Taiwanese patients. These results suggest that HCV prevalence and genotype distribution vary from region to region in China, and that the HCV now predominant in China may have evolved epidemiologically with infections in Japan and Taiwan. The study identified a high frequency of non-B, non-C chronic liver disease in China, suggesting possibly a new agent or infections with extreme variants of HCV.
Effect of beta-hydroxybutyrate on whole-body leucine kinetics and fractional mixed skeletal muscle protein synthesis in humans. (1988)

Because intravenous infusion of beta-hydroxybutyrate (beta-OHB) has been reported to decrease urinary nitrogen excretion, we investigated in vivo metabolism of leucine, an essential amino acid, using L-[1-13C]leucine as a tracer during beta-OHB infusion. Leucine flux during beta-OHB infusion did not differ from leucine flux during normal saline infusion in nine normal subjects, whereas leucine oxidation decreased 18-41% (mean = 30%) from 18.1 +/- 1.1 mumol.kg-1.h-1 (P less than 0.01), and incorporation of leucine into skeletal muscle protein increased 5-17% (mean = 10%) from 0.048 + 0.003%/h (P less than 0.02). Since blood pH during beta-OHB infusion was higher than the pH during saline infusion, we performed separate experiments to study the effect of increased blood pH on leucine kinetics by infusing sodium bicarbonate intravenously. Blood pH during sodium bicarbonate infusion was similar to that observed during the beta-OHB infusion, but bicarbonate infusion had no effect on leucine flux or leucine oxidation. We conclude that beta-OHB decreases leucine oxidation and promotes protein synthesis in human beings.
Hamlet on the holodeck: the future of narrative in cyberspace (1997)

Stories define how we think, the way we play, and the way we understand our lives. And just as Gutenberg made possible the stories that ushered in the Modem Era, so is the computer having a profound effect on the stories of the late 20th century. Today we are confronting the limits of books themselves -- anticipating the end of storytelling as we know it -- even as we witness the advent of a brave new world of cyberdramas. Computer technology of the late twentieth century is astonishing, thrilling, and strange, and no one is better qualified than Janet Murray to offer a breathtaking tour of how it is reshaping the stories we live by. Can we imagine a world in which Homer's Iyre and Gutenberg's press have given way to virtual reality environments like the Star Trek ® holodeck? Murray sees the harbingers of such a world in the fiction of Borges and Calvino, movies like Groundhog Day, and the videogames and Web sites of the 1990s. Where is our map for this new frontier, and what can we hope to find in it? What will it be like to step into our own stories for the first time, to change our vantage point at will, to construct our own worlds or change the outcome of a compelling adventure, be it a murder mystery or a torrid romance? Taking up where Marshall McLuhan left off, Murray offers profound and provocative answers to these and other questions. She discusses the unique properties and pleasures of digital environments and connects them with the traditional satisfactions of narrative. She analyzes the state of immersion, of participating in a text to such an extent that you literally get lost in a story and obliterate the outside world from your awareness. Shedissects the titillating effect of cyber-narratives in which stories never climax and never end, because everything is morphable, and there are always infinite possibilities for the next scene. And she introduces us to enchanted landscapes populated by witty automated characters and inventive role-playing interactors, who together make up a new kind of commedia dell'arte. Equal parts daydream and how-to, Hamlet on the Holodeck is a brilliant blend of imagination and techno-wizardry that will provoke readers and guide writers for years to come.
Micro-programming and the design of the control circuits in an electronic digital computer (1953)

Experience has shown that the sections of an electronic digital computer which are easiest to maintain are those which have a simple logical structure. Not only can this structure be readily borne in mind by a maintenance engineer when looking for a fault, but it makes it possible to use fault-locating programmes and to test the equipment without the use of elaborate test gear. It is in the control section of electronic computers that the greatest degree of complexity generally arises. This is particularly so if the machine has a comprehensive order code designed to make it simple and fast in operation. In general, for each different order in the code some special equipment must be provided, and the more complicated the function of the order the more complex this equipment. In the past, fear of complicating unduly the control circuits of the machines has prevented the designers of electronic machines from providing such facilities as orders for floating-point operations, although experience with relay machines and with interpretive subroutines has shown how valuable such orders are.