gebhart/patrepeval huggingface dataset:
Automated Dynamic Analysis of Ransomware: Benefits, Limitations and use for Detection (2016)

Recent statistics show that in 2015 more than 140 millions new malware samples have been found. Among these, a large portion is due to ransomware, the class of malware whose specific goal is to render the victim's system unusable, in particular by encrypting important files, and then ask the user to pay a ransom to revert the damage. Several ransomware include sophisticated packing techniques, and are hence difficult to statically analyse. We present EldeRan, a machine learning approach for dynamically analysing and classifying ransomware. EldeRan monitors a set of actions performed by applications in their first phases of installation checking for characteristics signs of ransomware. Our tests over a dataset of 582 ransomware belonging to 11 families, and with 942 goodware applications, show that EldeRan achieves an area under the ROC curve of 0.995. Furthermore, EldeRan works without requiring that an entire ransomware family is available beforehand. These results suggest that dynamic analysis can support ransomware detection, since ransomware samples exhibit a set of characteristic features at run-time that are common across families, and that helps the early detection of new variants. We also outline some limitations of dynamic analysis for ransomware and propose possible solutions.
Phase II Multi-Institutional Trial of the Histone Deacetylase Inhibitor Romidepsin As Monotherapy for Patients With Cutaneous T-Cell Lymphoma (2009)

PURPOSE Romidepsin (depsipeptide or FK228) is a member of a new class of antineoplastic agents active in T-cell lymphoma, the histone deacetylase inhibitors. On the basis of observed responses in a phase I trial, a phase II trial of romidepsin in patients with T-cell lymphoma was initiated. PATIENTS AND METHODS The initial cohort was limited to patients with cutaneous T-cell lymphoma (CTCL), or subtypes mycosis fungoides or Sézary syndrome, who had received no more than two prior cytotoxic regimens. There were no limits on other types of therapy. Subsequently, the protocol was expanded to enroll patients who had received more than two prior cytotoxic regimens. Results Twenty-seven patients were enrolled onto the first cohort, and a total of 71 patients are included in this analysis. These patients had undergone a median of four prior treatments, and 62 patients (87%) had advanced-stage disease (stage IIB, n = 15; stage III, n= 6; or stage IV, n = 41). Toxicities included nausea, vomiting, fatigue, and transient thrombocytopenia and granulocytopenia. Pharmacokinetics were evaluated with the first administration of romidepsin. Complete responses were observed in four patients, and partial responses were observed in 20 patients for an overall response rate of 34% (95% CI, 23% to 46%). The median duration of response was 13.7 months. CONCLUSION The histone deacetylase inhibitor romidepsin has single-agent clinical activity with significant and durable responses in patients with CTCL.
Blood Flow Regulation by S -Nitrosohemoglobin in the Physiological Oxygen Gradient (1997)

The binding of oxygen to heme irons in hemoglobin promotes the binding of nitric oxide (NO) to cysteinebeta93, forming S-nitrosohemoglobin. Deoxygenation is accompanied by an allosteric transition in S-nitrosohemoglobin [from the R (oxygenated) to the T (deoxygenated) structure] that releases the NO group. S-nitrosohemoglobin contracts blood vessels and decreases cerebral perfusion in the R structure and relaxes vessels to improve blood flow in the T structure. By thus sensing the physiological oxygen gradient in tissues, hemoglobin exploits conformation-associated changes in the position of cysteinebeta93 SNO to bring local blood flow into line with oxygen requirements.
High-speed, photonic analog-to-digital conversion using phase modulation (2001)

Summary form only given. Photonic systems provide an attractive means for increasing the sampling rate and resolution of analog-to-digital converters (ADCs) through their high dynamic range, broadband sampling, and low-noise optical clocks. Many techniques have been introduced over the past 25 years utilizing parallel-channel optical modulation, wavelength-division multiplexing, time-division multiplexing, and time-stretching techniques. Here a new technique is presented utilizing a pipeline method of analog-to-digital conversion by using phase modulators. This technique borrows the idea of converting the data from analog to digital in the optical system from H.F. Taylor (1979). Taylor has chosen to process the data in parallel optical channels with Mach-Zehnder interferometers, whereas the phase modulation technique in this paper allows a pipeline scheme utilizing just one channel. This reduces the system's electrical signal power, optical components, and size.
Pyruvate dehydrogenase deficiency caused by deletion of a 7-bp repeat sequence in the E1 alpha gene. (1990)

A 7-bp deletion in the X-chromosomal pyruvate dehydrogenase (PDH) E1 alpha gene was characterized in a female patient with the "cerebral" form of PDH deficiency. The mutation was localized using the chemical cleavage method and further characterized by application of the polymerase chain reaction and DNA sequencing. This 7-bp sequence is found in the normal gene as a direct tandem repeat. The deletion causes a change in the reading frame. Results have shown that the level of normal sized PDH E1 alpha in the fibroblast sample was approximately 30% of that of normal controls. This is consistent with normal transcription from the X chromosome carrying the nonmutated form of the E1 alpha subunit, as this chromosome is active in approximately 30% of this patient's cells. The severity of PDH E1 alpha deficiency in affected females is to a large extent dependent on the X-chromosome inactivation pattern in the brain. The clinical picture might therefore vary significantly between patients with the same mutation. We show that the 7-bp deletion must be a de novo mutation, because it is not present in the parent's X chromosomes. Furthermore, the deletion was not detected in chorionic villus samples in two subsequent pregnancies.
Role of the sar locus of Staphylococcus aureus in induction of endocarditis in rabbits (1994)

A regulatory locus on the Staphylococcus aureus chromosome, designated sar, is involved in the expression of cell wall proteins, some of which are potentially important in the pathogenesis of endocarditis. For instance, mutant 11D2 (sar::Tn917LTV1) was found to bind substantially less to matrix proteins (i.e., fibrinogen and fibronectin) than parent strain DB. Remarkably, these two strains did not differ in other phenotypes considered important in the initiation of endocarditis (e.g., binding to platelets and resistance to platelet-derived microbicidal proteins). The isogenic pair were compared for pathogenicity in a rabbit endocarditis model. There were significant differences in infectivity rates between the two strains (71 and 88% for DB versus 17 and 42% for mutant 11D2 at inocula of 10(3) and 10(4) CFU, respectively). In early adherence studies, parent DB adhered substantially better than the mutant to valvular vegetations at an inoculum of 10(6) CFU (P = 0.05). Southern blot analysis of colonies indicated that the location of the Tn917LTV1 insert in mutant 11D2 remained stable after animal passage. In vitro adherence assays revealed that mutant 11D2 was less adherent to cultured human endothelium than parent DB. These studies suggest that the sar locus is involved in the initial adherence of S. aureus to the fibrin-platelet-endothelium matrix on damaged valvular endothelium.
Exploring the Acceptor Substrate Recognition of the Human β-Galactoside α2,6-Sialyltransferase (2001)

Human beta1,4-galactoside alpha2,6-sialyltransferase I (ST6GalI) recognition of glycoprotein acceptors has been investigated using various soluble forms of the enzyme deleted to a variable extent in the N-terminal half of the polypeptide. Full-length and truncated forms of the enzyme have been investigated with respect to their specificity for a variety of desialylated glycoproteins of known complex glycans as well as related proteins with different carbohydrate chains. Differences in transfer efficiency have been observed between membrane and soluble enzymatic forms, indicating that deletion of the transmembrane fragment induces loss of acceptor preference. No difference in substrate recognition could be observed when soluble enzymes of similar peptide sequence were produced in yeast or mammalian cells, confirming that removal of the membrane anchor and heterologous expression do not alter enzyme folding and activity. When tested on free oligosaccharides, soluble ST6GalI displayed full ability to sialylate free N-glycans as well as various N-acetyllactosaminyl substrates. Progressive truncation of the N terminus demonstrated that the catalytic domain can proceed with sialic acid transfer with increased efficiency until 80 amino acids are deleted. Fusion of the ST6GalI catalytic domain to the N-terminal half of an unrelated transferase (core 2 beta1,6-N-acetylglucosaminyltransferase) further showed that a chimeric form of broad acceptor specificity and high activity could also be engineered in vivo. These findings therefore delineate a peptide region of approximately 50 amino acids within the ST6GalI stem region that governs both the preference for glycoprotein acceptors and catalytic activity, thereby suggesting that it may exert a steric control on the catalytic domain.
Role of blood pressure and the renin-angiotensin system in development of diabetic nephropathy (DN) in eNOS−/− db/db mice (2011)

Randomized clinical trials have clearly shown that inhibition of the renin-angiotensin system (RAS) will slow the rate of progression of diabetic nephropathy, but controversy remains about whether the observed beneficial effects result from more than control of blood pressure. Deletion of eNOS in a model of type II diabetes, db/db mice (eNOS(-/-) db/db), induces an accelerated nephropathy and provides an excellent model of human diabetic nephropathy. As is frequently seen in type II diabetes, blood pressure is moderately elevated in eNOS(-/-) db/db mice. To determine the role of elevated blood pressure per se vs. additional deleterious effects of the RAS in mediation of disease progression, 8-wk-old eNOS(-/-) db/db mice were randomly divided into three groups: vehicle, treatment with the angiotensin-converting enzyme inhibitor (ACEI) captopril, or treatment with "triple therapy" (hydralazine, resperine, hydrocholorothiazide), and the animals were euthanized after treatment for 12 wk. Blood pressure was reduced to comparable levels with ACE inhibition or triple therapy. Although both treatment regimens decreased development of diabetic nephropathy, ACE inhibition led to more profound reductions in albuminuria, glomerulosclerosis, markers of tubulointerstitial injury, macrophage infiltration, and markers of inflammation. Therefore, this animal model suggests that while there is an important role for blood pressure control, RAS blockade provides additional benefits in slowing the progression of diabetic nephropathy.
Analysis of a hydrogen-oxygen semi-closed rankine cycle propulsion plant for deep submersibles. (1972)

A semi-closed Rankine cycle propulsion plant for the propulsion of a small deep diving submersible vehicle is analyzed. The propulsion plant is fueled by cryogenic hydrogen and oxygen. Weights and volumes, efficiencies of various plant com-ponents are estimated, and the plant is compared with competi-tive propulsion plants for a 50 kw, 1000 kwh mission at depths of 8000 and 20,000 feet. Weight of the plant in air is about 5500 pounds heavier than a comparable Brayton cycle propulsion plant at the 20,000 foot depth and about twice the weight of a hydrogen-oxygen fuel cell plant. It is about half the weight of a comparable silver-zinc battery system. At the 8000 foot depth it is about 1000 pounds heavier than the Brayton cycle plant. A porous plug combustion chamber employing premixed hydro-gen, oxygen and steam is evaluated, and a novel three-four disk axial impulse re-entry turbine is designed using turbine inter-stage leakage equations developed. A computer analysis of film condensation with superheated steam in the presence of three non-condensable gases is presented for a horizontal tube and shell condenser.
Human bradykinin B2 receptors isolated by receptor-specific monoclonal antibodies are tyrosine phosphorylated. (1993)

We report the immunoaffinity isolation of bradykinin B2 receptors in a tyrosine-phosphorylated state from WI-38 human lung fibroblasts. We generated six monoclonal antibodies directed against B2 bradykinin receptor biologic activity mediating prostaglandin E2 production in WI-38. These cells express a repertoire of bradykinin receptor affinity forms with closely correlated biologic activity and [3H]bradykinin binding. Some of the monoclonal antibodies selectively recognize intermediate-affinity (Kd = 5.6 nM) or low-affinity (Kd = 42 nM) receptor forms, whereas others recognize epitopes common to both. The monoclonal antibodies block bradykinin binding and biologic activity. Immunoaffinity chromatography on an immobilized monoclonal antibody of intermediate- plus low-affinity specificity yields WI-38 B2 receptors with intact [3H]bradykinin binding activity and a molecular mass of 78 kDa. The same band is immunoblotted by all the monoclonal antibodies, indicating a similar molecular mass for receptor forms of different affinity. Anti-phosphotyrosine antibodies demonstrate that the receptors are tyrosine phosphorylated, with implications for receptor function and regulation. Genistein completely inhibits bradykinin-mediated prostaglandin E2 production with an IC50 of 8 microM, indicating that tyrosine kinase activity is critical for the signal transduction leading to arachidonic acid release.
Improved visual performance in letter perception through edge orientation encoding in a retinal prosthesis simulation (2014)

Objective. Stimulation strategies for retinal prostheses predominately seek to directly encode image brightness values rather than edge orientations. Recent work suggests that the generation of oriented elliptical phosphenes may be possible by controlling interactions between neighboring electrodes. Based on this, we propose a novel stimulation strategy for prosthetic vision that extracts edge orientation information from the intensity image and encodes it as oriented elliptical phosphenes. We test the hypothesis that encoding edge orientation via oriented elliptical phosphenes leads to better alphabetic letter recognition than standard intensity-based encoding. Approach. We conduct a psychophysical study with simulated phosphene vision with 12 normal-sighted volunteers. The two stimulation strategies were compared with variations of letter size, electrode drop-out and spatial offsets of phosphenes. Main results. Mean letter recognition accuracy was significantly better with the new proposed stimulation strategy (65%) compared to direct grayscale encoding (47%). All examined parameters-stimulus size, phosphene dropout, and location shift-were found to influence the performance, with significant two-way interactions between phosphene dropout and stimulus size as well as between phosphene dropout and phosphene location shift. The analysis delivers a model of perception performance. Significance. Displaying available directional information to an implant user may improve their visual performance. We present a model for designing a stimulation strategy under the constraints of existing retinal prostheses that can be exploited by retinal implant developers to strategically employ oriented phosphenes.
Dimethyl fumarate for treating relapsing multiple sclerosis (2014)

DMF is generally safe and well tolerated. Flushing and gastrointestinal side effects are relatively common for the approved DMF dose but are ordinarily mild and self-limited. No increase in malignancies has been reported despite theoretical concerns. Although progressive multifocal encephalopathy has been reported anecdotally in 5 of > 196,000 patient-years of experience with fumaric acid esters, none of the 65,000 DMF MS patients treated in the first year has been affected. Appendix to the abstract: Subsequent to the acceptance of this article for publication, the manufacturer has notified physicians of the death of one patient from PML complicating use of DMF in the DEFINE study extension (ENDORSE). This does not alter the expert opinion rendered regarding the safety of DMF. We await the outcomes and recommendations from the ongoing investigation into this case.
Description of Thermus thermophilus (Yoshida and Oshima) comb. nov., a Nonsporulating Thermophilic Bacterium from a Japanese Thermal Spa (1974)

The properties of an extremely thermophilic bacterium isolated from water at a Japanese hot spring and previously named Flavobacterium thermophilum are described. The cells are gram-negative, nonsporulating, aerobic rods containing yellow pigment. The optimum temperature for growth is between 65 and 72 C, the maximum being 85 C and the minimum being 47 C. The guanine plus cytosine content of the deoxyribonucleic acid of the thermophile is 69 mol %. This microorganism is sensitive to various antibiotics including those which are known to be rather ineffective against gram-negative bacteria. Spheroplast-like bodies are formed upon treating intact cells with egg-white lysozyme at 60 C. The spheres are osmotically more stable than mesophile protoplasts, and their rupture under hypotonic conditions is not complete unless 0.5% Brij 58 is added to the suspension. Bulk protein extracted from this thermophile is much more stable to heat than mesophile proteins, and only about 10% of the total protein is denatured by heating at 110 C for 5 min. Nevertheless, the amino acid composition of the bulk protein is similar to that of mesophile proteins. As the properties of this organism are similar to those of Thermus aquaticus (Brock and Freeze) and inasmuch as Flavobacterium is a poorly defined genus, this thermophilic microorganism is transferred to the genus Thermus as T. thermophilus (Yoshida and Oshima) comb. nov. The type strain is HB8 (=ATCC 27634).
Expression of Sry, the mouse sex determining gene (1995)

In the mouse, Sry is expressed by germ cells in the adult testis and by somatic cells in the genital ridge. Transcripts in the former exist as circular RNA molecules of 1.23 kb, which are unlikely to be efficiently translated. We have used RNase protection to map the extent of the less abundant Sry transcript in the developing gonad. We demonstrate that it is a linear mRNA derived from a single exon. This begins in the unique region 5' of the protein coding region and extends several kilobases into the 3' arm of the large inverted repeat which bounds the Sry genomic locus. Knowledge of this transcript, which is very different from that of the human SRY gene, allows us to predict its protein product and reveals several features which may be involved in translational control. Our data is also consistent with there being two promoters for the Sry gene, a proximal one that gives functional transcripts in the genital ridge and a distal promoter used in germ cells in the adult testis. As RNase protection is a quantitative technique, a detailed timecourse of Sry expression was carried out using accurately staged samples. Sry transcripts are first detectable just after 10.5 days post coitum, they reach a peak at 11.5 days and then decline sharply so that none are detected 24 hours later. This was compared with anti-Müllerian hormone gene expression, an early marker of Sertoli cells and the first known downstream gene of Sry. Amh expression begins 20 hours after the onset of Sry expression at a time when Sry transcripts are at their peak. While this result does not prove a direct interaction between the two genes, it defines the critical period during which Sry must act to initiate Sertoli cell differentiation.
Novel architecture for a high performance full custom graphics processor (2003)

The design and architectural features of a 32-b microprogrammed graphics processor are discussed. A description is given of the application of datapath elements and the exploitation of VRAM hardware, to achieve state-of-the-art processor performance levels. The host interface is discussed, along with video control, screen refresh control, and emulation and testability.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Genome reorganization in Nicotiana asymmetric somatic hybrids analysed by in situ hybridization (1992)

In situ hybridization was used to examine genome reorganization in asymmetric somatic hybrids between Nicotiana plumbaginifolia and Nicotiana sylvestris obtained by fusion of gamma-irradiated protoplasts from one of the parents (donor) with non-irradiated protoplasts from the other (recipient). Probing with biotinylated total genomic DNA from either the donor or the recipient species unequivocally identified genetic material from both parents in 31 regenerant plants, each originating from a different nuclear hybrid colony. This method, termed genomic in situ hybridization (GISH), allowed intergenomic translocations containing chromosome segments from both species to be recognized in four regenerants. A probe homologous to the consensus sequence of the Arabidopsis thaliana telomeric repeat (5'-TTTAGGG-3')n, identified telomeres on all chromosomes, including 'mini-chromosomes' originating from the irradiated donor genome. Genomic in situ hybridization to plant chromosomes provides a rapid and reliable means of screening for recombinant genotypes in asymmetric somatic hybrids. Used in combination with other DNA probes, it also contributes to a greater understanding of the events responsible for genomic recovery and restabilization following genetic manipulation in vitro.
Erbium emission from porous silicon one-dimensional photonic band gap structures (2000)

We report tunable, narrow, directional, and enhanced erbium emission from one-dimensional photonic band gap structures. The structures are prepared by anodic etching of crystalline silicon and consist of two highly reflecting porous silicon Bragg reflectors sandwiching an active layer. The cavities are doped by cathodic electromigration of the erbium ions into the porous silicon matrix, followed by high temperature oxidation. By controlling the oxidation temperature of the structure, the position of the erbium emission near 1.5 μm is tuned to regions where the natural erbium spectrum is very weak. The erbium emission from the cavity is narrowed to a full width at half maximum of 12 nm with a quality factor Q of 130, highly directional with a 20° emission cone around the normal axis, and enhanced by more than one order of magnitude.
Update: Clinically Significant Cytochrome P‐450 Drug Interactions (1998)

Recent technologies have resulted in an explosion of information concerning the cytochrome P-450 isoenzymes and increased awareness of life-threatening interactions with such commonly prescribed drugs as cisapride and some antihistamines. Knowledge of the substrates, inhibitors, and inducers of these enzymes assists in predicting clinically significant drug interactions. In addition to inhibition and induction, microsomal drug metabolism is affected by genetic polymorphisms, age, nutrition, hepatic disease, and endogenous chemicals. Of the more than 30 human isoenzymes identified to date, the major ones responsible for drug metabolism include CYP3A4, CYP2D6, CYP1A2, and the CYP2C subfamily.
Detection of aberrant p16 methylation in the serum of colorectal cancer patients. (2002)

This assay offers a potential means for the serum-based detection and/or monitoring of CRC patients.