gebhart/patrepeval huggingface dataset:
Moirae: History-Enhanced Monitoring. (2007)

In this paper, we present the benefits and challenges of integrating history into a near-real-time monitoring system. In particular, we address the specific problem of enhancing current events with historical information, by efficiently retrieving for each newly detected event similar past events (e.g., car accidents, network intrusions, server failures). We focus on applications where querying a historical log in its entirety would be too slow to meet application needs, and could potentially yield an overwhelming number of results. We propose a general purpose continuous monitoring system, called Moirae, that efficiently produces with each new event an approximate set of most similar recent events. We present the design of Moirae, show how our proposed architecture achieves the above goals, and discuss the applicability of the architecture to other types of integration between historical data and continuous monitoring. 1.
Evolution of codon usage patterns: the extent and nature of divergence betweenCandida albicansandSaccharomyces cerevisiae (1992)

Codon usage in a sample of 28 genes from the pathogenic yeast Candida albicans has been analysed using multivariate statistical analysis. A major trend among genes, correlated with gene expression level, was identified. We have focussed on the extent and nature of divergence between C.albicans and the closely related yeast Saccharomyces cerevisiae. It was recently suggested that significant differences exist between the subsets of preferred codons in these two species [Brown et al. (1991) Nucleic Acids Res. 19, 4293]. Overall, the genes of C.albicans are more A + T-rich, reflecting the lower genomic G + C content of that species, and presumably resulting from a different pattern of mutational bias. However, in both species highly expressed genes preferentially use the same subset of 'optimal' codons. A suggestion that the low frequency of NCG codons in both yeast species results from selection against the presence of codons that are potentially highly mutable is discounted. Codon usage in C.albicans, as in other unicellular species, can be interpreted as the result of a balance between the processes of mutational bias and translational selection. Codon usage in two related Candida species, C.maltosa and C.tropicalis, is briefly discussed.
Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX (2002)

Chronic lymphocytic leukemia (CLL) is associated with a variety of immunologic disturbances. Hypogammaglobulinemia and autoimmune phenomena are both often present in this disease. In contrast, humoral or cellular antitumor responses are rarely observed. It has been previously shown that antigens detected in patients with malignant diseases can provide information regarding intracellular molecules engaged in the transformation process and can identify tumor antigens that may be useful for development of immunotherapeutic strategies. Serologic identification by recombinant expression cloning (SEREX) has been demonstrated to be a useful method to detect tumor and tumor-associated antigens in a variety of malignancies. Although this approach is complicated in CLL, we used a modified SEREX approach and identified 14 antigens (KW-1 to KW-14) using this methodology. Several clones showed a restricted expression pattern in normal tissues. Moreover, distinctive expression of splice variants and aberrant gene expression in malignant tissue were detected. In this study, 6 antigens were detected exclusively in patients with CLL. Eight antigens were detected also in lymphoma patients. Healthy donors showed antibody responses against only 3 of the identified antigens. T cells with specific cytotoxicity against peptides derived from the 2 antigens tested could be generated from healthy donors. These findings demonstrate that humoral and cellular immune responses against CLL-associated antigens can be detected. Ongoing experiments investigate their potential for the development of immunotherapeutic strategies.
METABOLISM OF L-LYSINE BY BACTERIAL ENZYME (1960)

Journal Article METABOLISM OF L-LYSINE BY BACTERIAL ENZYME: II. L-LYSINE OXIDASE Get access HIROSHI HAGIHIRA, HIROSHI HAGIHIRA From the Department of Physiological Chemistiy, Medical School, and the Institute for Protein ResearchOsaka University, Osaka Search for other works by this author on: Oxford Academic PubMed Google Scholar HIDEYUKI HAYASHI, HIDEYUKI HAYASHI From the Department of Physiological Chemistiy, Medical School, and the Institute for Protein ResearchOsaka University, Osaka Search for other works by this author on: Oxford Academic PubMed Google Scholar AKIRA ICHIHARA, AKIRA ICHIHARA From the Department of Physiological Chemistiy, Medical School, and the Institute for Protein ResearchOsaka University, Osaka Search for other works by this author on: Oxford Academic PubMed Google Scholar MASAMI SUDA MASAMI SUDA From the Department of Physiological Chemistiy, Medical School, and the Institute for Protein ResearchOsaka University, Osaka Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 48, Issue 2, August 1960, Pages 267–276, https://doi.org/10.1093/oxfordjournals.jbchem.a127168 Published: 01 August 1960 Article history Received: 10 March 1960 Published: 01 August 1960
Direct Observation of Vapor−Liquid−Solid Nanowire Growth (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTDirect Observation of Vapor−Liquid−Solid Nanowire GrowthYiying Wu and Peidong YangView Author Information Materials Science Division Lawrence Berkeley National Laboratory Department of Chemistry University of California, Berkeley, California 94720 Cite this: J. Am. Chem. Soc. 2001, 123, 13, 3165–3166Publication Date (Web):March 13, 2001Publication History Received20 December 2000Published online13 March 2001Published inissue 1 April 2001https://pubs.acs.org/doi/10.1021/ja0059084https://doi.org/10.1021/ja0059084rapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views11573Altmetric-Citations917LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alloys,Crystallization,Gold,Metal clusters,Nanowires Get e-Alerts
Recent advances in nonalcoholic fatty liver disease (2010)

Purpose of review This review focuses on recent advances in the study of the epidemiology, pathogenesis, natural history and treatment of nonalcoholic fatty liver disease (NAFLD). Recent findings Study of hepatic lipid metabolism, insulin resistance, mitochondrial dysfunction and oxidative stress, genetic variants and predisposition to altered metabolism and cell injury have contributed to our current understanding of NAFLD. Differential expression of microRNA in fatty liver and its implication in disease pathogenesis and therapeutic potential have continued to advance over the year. The pathogenesis of hepatocellular carcinoma in steatohepatitis continues to be explored. The diagnostic utility of imaging and noninvasive markers seems promising in estimating the severity of steatosis and fibrosis. Liver biopsy remains the gold standard for accurately assessing NAFLD and steatohepatitis. Lifestyle modification and weight loss improve both metabolic profile and liver histology. Pharmacotherapy for the treatment of NAFLD remains lacking. Summary The underlying mechanism and pathogenesis of NAFLD remain elusive despite ongoing researches to make significant advances in the understanding of its natural history, pathogenesis and management. Pharmacotherapy has yet to indicate a promising therapeutic intervention. Current treatment focuses on managing underlying cardio-metabolic risks.
Long-term suspension cultures of human cord blood myeloid cells (1981)

A method is described that allows for the routine long-term (greater than 3 mo) growth of normal, immature human myeloid cells in liquid suspension culture. The techniques employ cell separation, utilization of special growth conditions (RPMI with hydrocortisone and vitamin D), and cord blood as the source of leukocytes. These cultures are composed predominantly of immature myeloid cells that have grown for over 3 mo in culture but eventually terminate as differentiated, mature granulocytes and monocyte-macrophages. Application of these techniques to other sources of fresh human leukocytes (bone marrow and adult peripheral blood) resulted in only short-term proliferation of myeloid cells. The techniques described can be used for the routine expansion of immature myeloid and monocytoid cell populations, particularly from newborns, and should be useful for systematic studies of normal myeloid- monocytoid cell growth and differentiation and providing normal control cells in studies employing human leukemic myeloid cells.
Prenatal Hypoxia Induced Dysfunction in Cerebral Arteries of Offspring Rats (2017)

Hypoxia in pregnancy could induce dysfunction in both contraction and dilation in the offspring MCA. AII-increased constriction in the prenatal-hypoxia group was not mainly dependent on the L-type and T-type calcium channels; it might predominantly rely on the AII receptors, IP<sub>3</sub>/ryanodine receptors, and the endoplasmic reticulum calcium store as well as calcium ATPase.
l-Tuple DNA Sequencing: Computer Analysis (1989)

A new method of DNA reading was proposed at the end of 1988 by Lysov et al. According to the authors' claims it has certain advantages as compared to the Maxam-Gilbert and Sanger methods, which are revealed by automation and rapidity of DNA sequencing. Nevertheless its employment is hampered by a number of biological and mathematical problems. The present study proposes an algorithm that allows to overcome the computational difficulties occurring in the course of the method during reconstruction of the DNA sequence by its l-tuple composition. It is shown also that the biochemical problems connected with the loss of information about the l-tuple DNA composition during hybridization are not crucial and can be overcome by finding the maximal flow of minimal cost in the special graph.
Special Edition Using Corel WordPerfect 9 (1999)

From the Publisher:
Discover the power of WordPerfect 9 and see what makes it one of the world's most popular word processing applications; learn the ins and outs of using the Writing Tools; master page layout formatting, styles, and templates; use lists and outlines to organize information; collaborate on WordPerfect 9 documents with others in your workgroup; master dozens of time-saving tricks; fax your documents from WordPerfect 9 or send as email attachments; add drawings, graphics, shapes, and images to your documents; customize graphic shapes and images; import data and work with other programs and applications; create and publish Web pages; and build interactive and multimedia documents.
Geminivirus-Mediated Delivery of Florigen Promotes Determinate Growth in Aerial Organs and Uncouples Flowering from Photoperiod in Cotton (2012)

These findings extend our understanding of FT as a general growth hormone that regulates shoot architecture by advancing organ-specific and age-related determinate growth. Judicious manipulation of FT could benefit cotton architecture to improve crop management.
New Insights into Sequential Infiltration Synthesis (2015)

Sequential infiltration synthesis (SIS) is a process derived from ALD in which a polymer is infused with inorganic material using sequential, self-limiting exposures to gaseous precursors. SIS can be used in lithography to harden polymer resists rendering them more robust towards subsequent etching, and this permits deeper and higher-resolution patterning of substrates such as silicon. Herein we describe recent investigations of a model system: Al<sub>2</sub>O<sub>3</sub> SIS using trimethyl aluminum (TMA) and H<sub>2</sub>O within the diblock copolymer, poly(styrene-block-methyl methacrylate) (PS-b-PMMA). Combining in-situ Fourier transform infrared absorption spectroscopy, quartz-crystal microbalance, and synchrotron grazing incidence small angle X-ray scattering with high resolution scanning transmission electron microscope tomography, we elucidate important details of the SIS process: 1) TMA adsorption in PMMA occurs through a weakly-bound intermediate; 2) the SIS kinetics are diffusion-limited, with desorption 10× slower than adsorption; 3) dynamic structural changes occur during the individual precursor exposures. These findings have important implications for applications such as SIS lithography.
A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms (2005)

Pseudomonas aeruginosa produces extracellular DNA which functions as a cell-to-cell interconnecting matrix component in biofilms. Comparison of extracellular DNA and chromosomal DNA by the use of polymerase chain reaction and Southern analysis suggested that the extracellular DNA is similar to whole-genome DNA. Evidence that the extracellular DNA in P. aeruginosa biofilms and cultures is generated via lysis of a subpopulation of the bacteria was obtained through experiments where extracellular beta-galactosidase released from lacZ-containing P. aeruginosa strains was assessed. Experiments with the wild type and lasIrhlI, pqsA, pqsL and fliMpilA mutants indicated that the extracellular DNA is generated via a mechanism which is dependent on acyl homoserine lactone and Pseudomonas quinolone signalling, as well as on flagella and type IV pili. Microscopic investigation of flow chamber-grown wild-type P. aeruginosa biofilms stained with different DNA stains suggested that the extracellular DNA is located primarily in the stalks of mushroom-shaped multicellular structures, with a high concentration especially in the outer part of the stalks forming a border between the stalk-forming bacteria and the cap-forming bacteria. Biofilms formed by lasIrhlI, pqsA and fliMpilA mutants contained less extracellular DNA than biofilms formed by the wild type, and the mutant biofilms were more susceptible to treatment with sodium dodecyl sulphate than the wild-type biofilm.
2-Decenoic acid ethyl ester possesses neurotrophin-like activities to facilitate intracellular signals and increase synapse-specific proteins in neurons cultured from embryonic rat brain (2010)

We presently found that medium-chain fatty acids (MCFAs) with 8-12 carbons and their esters facilitated activation (phosphorylation) of mitogen-activated protein kinases (MAPK)/extracellular signal-regulated kinases (ERK) 1/2 of cultured embryonic cortical/hippocampal neurons. In particular, trans-2-decenoic acid ethyl ester (DAEE) had the most potent activity. Additionally, DAEE activated phosphatidylinositol 3-kinase and cAMP-response element binding protein (CREB), suggesting that DAEE generates similar intracellular signal as neurotrophins. Therefore, details of the signal elicited by DAEE were examined in comparison with those of a neurotrophin, brain-derived neurotrophic factor (BDNF). We found that 1) DAEE phosphorylated MAPK/ERK1/2 via MEK activation without the involvement of tyrosine kinases of neurotrophin Trk receptors; 2) DAEE activated CREB predominantly through MAPK/ERK1/2 activation, not through other pathways such as cAMP/protein kinase A; and 3) DAEE increased the expression of RNAs of BDNF and neurotrophin-3 and the protein content of synapse-specific proteins such as synaptophysin, synapsin-1, and syntaxin. Based on these observations we propose that DAEE and some other derivatives of MCFAs having neurotrophin-like neurotrophic activities may become therapeutic tools for certain neurological or psychiatric disorders.
Adaptivity to background noise spatial coherence for high resolution passive methods (2005)

Researchs directed towards improvement of underwater passive listening techniques have led to high resolution methods which are based on the eigenvalues eigen vectors decomposition of the spectral density matrix of the signals received on the sensors of the array. These methods require the knowledge of the spatial coherence of sources and background noise. It is shown in this paper that if the spatial coherence of the background noise is not exactly known but can be modelized by a function which depends on some parameters, these parameters can be estimated and the high resolution method carried out.
Halocarbons as Halon Replacements. Volume 1. Technology Review and Initiation (1991)

The objective of this overall project is to develop one or more alternative clean halocarbon fire extinguishing streaming agents to replace Halon 1211. In this effort a technology review was conducted and an experimental plan was prepared. Screening criteria are presented with discussions and approaches to meeting the following criteria: cleanliness, toxicity, fire suppression, ozone depletion potentials (ODPs), global warming potentials (GWPs) , physical properties, availability/manufacturability, cost, materials compatibility, and chemical stability. Lists of near-, medium-, and far-term candidate agents are presented. An algorithm was developed that enables prediction of atmospheric lifetimes of hydrogen-containing one-and two-carbon haloalkanes containing fluorine and/or chlorine. Relationships are examined among C-H bond strength, activation energy for hydrogen abstraction by OH, reaction rate constants, tropospheric lifetimes, and ODPs. A review of existing and emerging technologies for the destruction of halocarbons is included.
Evidential Multisensor Fusion and Erroneous Management of Lanes for Autonomous Driving (2019)

Lane information is essential for safe autonomous driving. In this article, we present a multisensor fusion framework for ego and adjacent lanes with a novel fusion quality measure and dynamic lane mode strategies for erroneous management. The framework fuses road marking lines based on Dempster-Shafer theory and tracks lanes with a particle filter. Then, a quality measure for each line is computed, integrating sensor coherence, availability as well as temporal continuity. This quality is essential to deploy different lane management strategies in order to avoid integrating erroneous data. The proposed framework was evaluated in a lateral control architecture with autonomous driving on open roads and proved its robustness and availability.
Identification of Volatile Flavor Compounds with High Aroma Values from Shallow-Fried Beef (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIdentification of Volatile Flavor Compounds with High Aroma Values from Shallow-Fried BeefK. Specht and Werner BaltesCite this: J. Agric. Food Chem. 1994, 42, 10, 2246–2253Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/jf00046a031https://doi.org/10.1021/jf00046a031research-articleACS PublicationsRequest reuse permissionsArticle Views866Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability (2012)

The CXC chemokine receptor-4 (CXCR4) plays a critical role in cancer by positively regulating cancer cell metastasis and survival. We previously showed that high concentrations of the CXCR4 ligand, wild-type CXCL12 (wtCXCL12), could inhibit colorectal cancer metastasis in vivo, and we have hypothesized that wtCXCL12 dimerizes at high concentration to become a potent antagonist of CXCR4. To address this hypothesis, we engineered a covalently locked, dimeric variant of CXCL12 (CXCL122). Herein, we show that CXCL122 can not only inhibit implantation of lung metastasis of CXCR4-B16-F10 melanoma cells more effectively than AMD3100, but that CXCL122 also blocks the growth of established pulmonary tumors. To identify a basis for the in vivo efficacy of CXCL122, we conducted Western blot analysis and ELISA analyses, which revealed that CXCL122 was stable for at least 12 hours in serum, whereas wtCXCL12 was quickly degraded. CXCL122 also maintained its antagonist properties in in vitro chemotaxis assays for up to 24 hours in serum, whereas wtCXCL12 was ineffective after 6 hours. Heat-inactivation of serum prolonged the stability and function of wtCXCL12 by more than 6 hours, suggesting enzymatic degradation as a possible mechanism for wtCXCL12 inactivation. In vitro analysis of amino-terminal cleavage by enzymes dipeptidylpeptidase IV (DPPIV/CD26) and matrix metalloproteinase-2 (MMP-2) resulted in 25-fold and 2-fold slower degradation rates, respectively, of CXCL122 compared with wtCXCL12. In summary, our results suggest CXCL122 possesses greater potential as an antimetastatic drug as compared with AMD3100 or wtCXCL12, potentially due to enhanced serum stability in the presence of N-terminal degrading enzymes.
Measurement of the thickness and refractive index of very thin films and the optical properties of surfaces by ellipsometry (1963)

The use of the ellipsometer for the measurement of the thickness and refractive index of very thin films is reviewed. The Poincaré sphere representation of the state of polarization of light is developed and used to describe the reflection process. Details of the operation of the ellipsometer are examined critically. A computational method is presented by which the thickness of a film of known refractive index on a reflecting substrate of known optical constants may be calculated directly from the ellipsometer readings. A method for computing both the refractive index and thickness of an unknown film is also developed. These methods have been applied to the determination of the thickness of an adsorbed water layer on chromium ferrotype plates and on gold surfaces. In the former case the thickness was 23 to 27 Å, and in the latter was 2 to 5 Å. The measurement of the thickness and refractive index of barium fluoride films evaporated on chromium ferrotype surfaces is used as an illustration of the simultaneous determination of these two quantities.