gebhart/patrepeval huggingface dataset:
Chronic Unloading by Left Ventricular Assist Device Reverses Contractile Dysfunction and Alters Gene Expression in End-Stage Heart Failure (2000)

LVAD support can improve contractile strength of intact myocardium and reverse the negative FFR associated with end-stage heart failure. The expression of genes encoding for proteins involved in Ca(2+) cycling is upregulated (reverse molecular remodeling), but only the protein content of SERCA2a is increased.
Baculovirus Induces an Innate Immune Response and Confers Protection from Lethal Influenza Virus Infection in Mice (2003)

A recombinant baculovirus expressing the hemagglutinin gene of the influenza virus, A/PR/8/34 (H1N1), under the control of the chicken beta-actin promoter, was constructed. To determine the induction of protective immunity in vivo, mice were inoculated with the recombinant baculovirus by intramuscular, intradermal, i.p., and intranasal routes and then were challenged with a lethal dose of the influenza virus. Intramuscular or i.p. immunization with the recombinant baculovirus elicited higher titers of antihemagglutinin Ab than intradermal or intranasal administration. However, protection from a lethal challenge of the influenza virus was only achieved by intranasal immunization of the recombinant baculovirus. Surprisingly, sufficient protection from the lethal influenza challenge was also observed in mice inoculated intranasally with a wild-type baculovirus, as evaluated by reductions in the virus titer, inflammatory cytokine production, and pulmonary consolidations. These results indicate that intranasal inoculation with a wild-type baculovirus induces a strong innate immune response, which protects mice from a lethal challenge of influenza virus.
Space-Time-Doppler coding over time-selective fading channels with maximum diversity and coding gains (2002)

We rely on a Basis Expansion Model (BEM) for the channel, to design three Space-Time-Doppler (SID) codecs that enable maximum diversity gains, when block transmissions undergo time-selective fading effects. Within the constraints of each maximum-diversity design, it is also possible to achieve maximum coding gain, at least when the BEM parameters are i.i.d. The theoretical results are corroborated by simulation results and the BEM is validated.
Predicting Transition Temperatures of Elastin-Like Polypeptide Fusion Proteins (2013)

Elastin-like polypeptides (ELPs) are thermally sensitive peptide polymers that undergo thermally triggered phase separation and this behavior is imparted to soluble proteins when they are fused to an ELP. The transition temperature of the ELP fusion protein is observed to be different than that of a free ELP, indicating that the surface properties of the fused protein modulate the thermal behavior of ELPs. Understanding this effect is important for the rational design of applications that exploit the phase transition behavior of ELP fusion proteins. We had previously developed a biophysical model that explained the effect of hydrophobic proteins on depressing the transition temperature of ELP fusion proteins relative to free ELP. Here, we extend the model to elucidate the effect of hydrophilic proteins on the thermal behavior of ELP fusion proteins. A linear correlation was found between overall residue composition of accessible protein surface weighted by a characteristic transition temperature for each residue and the difference in transition temperatures between the ELP protein fusion and the corresponding free ELP. In breaking down the contribution of residues to polar, nonpolar, and charged, the model revealed that charged residues are the most important parameter in altering the transition temperature of an ELP fusion relative to the free ELP.
M-Face: An Appearance-Based Photorealistic Model for Multiple Facial Attributes Rendering (2006)

A novel framework for appearance-based photorealistic facial modeling, called Merging Face (M-Face), is presented and applied to generate emotional facial attributes in rotated views. Assuming that human faces belong to both the linear object class and the Lambertian object class, we span the face space and attribute space, respectively, by using groups of prototypes and merging ratio image (MRI). The MRI is defined as the seamless blend of individual expression ratio image, aging ratio image, and illumination ratio image (quotient image). The M-Face integrates the view space projection, shape caricaturing, and texture MRI-mapping techniques. Derived from the average face, the caricatured shape is reshaped to be more distinct by exaggerating individual distinctiveness, while the rerendered texture multiplies the MRI information during the caricaturing. Based on the M-Face model, the expression morphing, chronological aging or rejuvenating, and illumination variance can be merged seamlessly in a photorealistic style on desired view-rotated faces yielded by view morphing. This framework has the following advantages. First, 3-D reconstruction is avoided without weakening photorealistic effects. Second, the integration of shape caricaturing and texture MRI-mapping proves by experiments to be an efficient and computational inexpensive strategy for realistic face synthesis. Finally, the M-Face is a 2-D parameter-driven model, which highly simplifies user manipulations. The potential applications of M-Face are in various fields like virtual human face, speech-driven talking head, digital painting, film-making, and low-bit-rate communication
Better optical triangulation through spacetime analysis (2002)

The standard methods for extracting range data from optical triangulation scanners are accurate only for planar objects of uniform reflectance illuminated by an incoherent source. Using these methods, curved surfaces, discontinuous surfaces, and surfaces of varying reflectance cause systematic distortions of the range data. Coherent light sources such as lasers introduce speckle artifacts that further degrade the data. We present a new ranging method based on analyzing the time evolution of the structured light reflections. Using our spacetime analysis, we can correct for each of these artifacts, thereby attaining significantly higher accuracy using existing technology. We present results that demonstrate the validity of our method using a commercial laser stripe triangulation scanner.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Surface Plasmon Resonance Scattering and Absorption of anti-EGFR Antibody Conjugated Gold Nanoparticles in Cancer Diagnostics:  Applications in Oral Cancer (2005)

Gold nanoparticles with unique optical properties may be useful as biosensors in living whole cells. Using a simple and inexpensive technique, we recorded surface plasmon resonance (SPR) scattering images and SPR absorption spectra from both colloidal gold nanoparticles and from gold nanoparticles conjugated to monoclonal anti-epidermal growth factor receptor (anti-EGFR) antibodies after incubation in cell cultures with a nonmalignant epithelial cell line (HaCaT) and two malignant oral epithelial cell lines (HOC 313 clone 8 and HSC 3). Colloidal gold nanoparticles are found in dispersed and aggregated forms within the cell cytoplasm and provide anatomic labeling information, but their uptake is nonspecific for malignant cells. The anti-EGFR antibody conjugated nanoparticles specifically and homogeneously bind to the surface of the cancer type cells with 600% greater affinity than to the noncancerous cells. This specific and homogeneous binding is found to give a relatively sharper SPR absorption band with a red shifted maximum compared to that observed when added to the noncancerous cells. These results suggest that SPR scattering imaging or SPR absorption spectroscopy generated from antibody conjugated gold nanoparticles can be useful in molecular biosensor techniques for the diagnosis and investigation of oral epithelial living cancer cells in vivo and in vitro.
Potential-Dependent Electron Injection in Nanoporous Colloidal ZnO Films (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotential-Dependent Electron Injection in Nanoporous Colloidal ZnO FilmsP. Hoyer and H. WellerCite this: J. Phys. Chem. 1995, 99, 38, 14096–14100Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/j100038a048https://doi.org/10.1021/j100038a048research-articleACS PublicationsRequest reuse permissionsArticle Views828Altmetric-Citations154LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon. (1995)

The CD44 cell surface glycoprotein is expressed on a broad range of different tissues as multiple isoforms containing from one to ten alternatively spliced exons v1-v10 inserted within the extracellular domain. Differential glycosylation generates still further variability, yielding both N- and O-glycan-modified forms of CD44 in addition to proteoglycan-like variants containing chondroitin sulphate and heparan sulphate. These high molecular mass proteoglycan-like variants, previously identified in lymphocytes, melanomas, and keratinocytes have been implicated in cell-matrix adhesion, cell motility, and invasiveness. More recently, monocyte CD44 molecules presumed to carry glycosaminoglycan chains were shown to bind the chemokine MIP-1 beta (Tanaka, Y.,D. H. Adams, S. Hubscher, H. Hirano, U. Siebenlist, and S. Shaw. 1993. Nature (Lond). 361:79-82.) raising the intriguing possibility that proteoglycan-like CD44 variants might play a role in regulating inflammatory responses. Here we have investigated the molecular identity of these proteoglycan-like CD44 variants by generating a panel of recombinant CD44 isoforms using a novel cassette cloning strategy. We show that both chondroitin and heparan sulphate modifications are associated specifically with isoforms (CD44v3-10 and CD44v3,8-10) containing the v3 alternative exon which encodes a consensus motif SGXG for GAG addition. Other isoforms (CD44v10, CD44v8-10, CD44v7-10, and CD44v6-10) are shown to lack these GAG chains but to carry extensive O-glycan modifications, most likely within the mucin-like alternative exon inserts. We also demonstrate that the majority of endogenous GAG-modified CD44 isoforms present in epithelial cells constitute v3 isoforms thus establishing that in these cells the majority of proteoglycan-like CD44 variants are generated by alternative splicing. Finally we present evidence using transfected B lymphoma cells that the GAG-modified CD44 isoforms CD44v3-10 and CD44v3,8-10, unlike CD44H, bind only weakly to hyaluronan. Together with the demonstration in the accompanying paper (Bennett, K., D. G. Jackson, J.C. Simon, E. Tanczos, R. Peach, B. Modrell, I. Stamenkovic, G. Plowman, and A. Aruffo. 1995. J. Cell Biol. 128:687-698.), that CD44 molecules containing the v3 exon bind growth factors, these results highlight a new and potentially important role for CD44 alternative splicing in the control of cell-surface proteoglycan expression.
A HECT Domain E3 Enzyme Assembles Novel Polyubiquitin Chains (2001)

Although polyubiquitin chains linked through Lys(29) of ubiquitin have been implicated in the targeting of certain substrates to proteasomes, the signaling properties of these chains are poorly understood. We previously described a ubiquitin-protein isopeptide ligase (E3) from erythroid cells that assembles polyubiquitin chains through either Lys(29) or Lys(48) of ubiquitin (Mastrandrea, L. D., You, J., Niles, E. G., and Pickart, C. M. (1999) J. Biol. Chem. 274, 27299-27306). Here we describe the purification of this E3 based on its affinity for a linear fusion of ubiquitin to the ubiquitin-conjugating enzyme UbcH5A. Among five major polypeptides in the affinity column eluate, the activity of interest was assigned to the product of a previously cloned human cDNA known as KIAA10 (Nomura, N., Miyajima, N., Sazuka, T., Tanaka, A., Kawarabayasi, Y., Sato, S., Nagase, T., Seki, N., Ishikawa, K., and Tabata, S. (1994) DNA Res. 1, 27-35). The KIAA10 protein is a member of the HECT (homologous to E6-AP carboxyl terminus) domain family of E3s. These E3s share a conserved C-terminal (HECT) domain that functions in the catalysis of ubiquitination, while their divergent N-terminal domains function in cognate substrate binding (Huibregtse, J. M., Scheffner, M., Beaudenon, S., and Howley, P. M. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 2563-2567). Recombinant KIAA10 catalyzed the assembly of both Lys(29)- and Lys(48)-linked polyubiquitin chains. Surprisingly, the C-terminal 428 residues of KIAA10 were both necessary and sufficient for this activity, suggesting that the ability to assemble polyubiquitin chains may be a general property of HECT domains. The N-terminal domain of KIAA10 interacted in vitro with purified 26 S proteasomes and with the isolated S2/Rpn1 subunit of the proteasome's 19 S regulatory complex, suggesting that the N-terminal domains of HECT E3s may function in proteasome binding as well as substrate binding.
High power, high efficiency window buried heterostructure GaAlAs superluminescent diode with an integrated absorber (1987)

A superluminescent diode (SLD) based on a proven high power, high efficiency ‘‘window-’’ type index-guided buried heterostructure laser is demonstrated. Lasing is suppressed for SLD operation by antireflection coating and by incorporating an unpumped absorber section. The resulting device emits high optical power (14 mW) in the SLD mode at very low injection current (50 mA). The spectral modulation depth is below 14% over the entire emission spectral bandwidth of 20 nm, with a symmetrical beam divergence (20°×40°) and a stable transverse mode.
Promotion of incisional wound repair by human mesenchymal stem cell transplantation (2008)

The purpose of this study was to determine the effect of transplanted human mesenchymal stem cells (hMSCs) on wound healing. In this model, full-thickness cutaneous wounds were created by incision in the skin of adult New Zealand white rabbits and treated by transplanted hMSCs into the wounds. Wound healing was evaluated by histological analysis and tensiometry over time. A total of 15 New Zealand white rabbits with 10 wounds per animal were examined in this study. Animals were treated with hMSCs and euthanised at 3, 7, 14, 21 and 80 days after manipulation. The hMSCs were labelled with a fluorescent dye (CM-DiI), suspended in phosphate-buffered saline and used to treat full-thickness incisional wounds in rabbit skin. Tensiometry and histology were used to characterise the wound-healing rate of the incisional wounds. These results showed that transplanted hMSCs significantly inhibited scar formation and increased the tensile strength of the wounds. Importantly, MSCs from genetically unrelated donors did not appear to induce an immunologic response. In conclusion, human mesenchymal stem cell therapy is a viable approach to significantly affect the course of normal cutaneous wound healing and significantly increase the tensile strength.
ShakeDrop regularization (2018)

This paper proposes a powerful regularization method named \textit{ShakeDrop regularization}. ShakeDrop is inspired by Shake-Shake regularization that decreases error rates by disturbing learning. While Shake-Shake can be applied to only ResNeXt which has multiple branches, ShakeDrop can be applied to not only ResNeXt but also ResNet, Wide ResNet and PyramidNet in a memory efficient way. Important and interesting feature of ShakeDrop is that it strongly disturbs learning by multiplying even a negative factor to the output of a convolutional layer in the forward training pass. The effectiveness of ShakeDrop is confirmed by experiments on CIFAR-10/100 and Tiny ImageNet datasets.
Prefractionation of protein samples prior to two‐dimensional electrophoresis (1997)

Thousands of proteins may be visualised on a two-dimensional (2-D) gel, but only hundreds are present at levels sufficient for chemical analysis. Therefore, prefractionation of protein samples prior to 2-D polyacrylamide gel electrophoresis (PAGE) will be important for the investigation of proteins that are present at sub-picogram levels in physiological samples. We describe an approach to prefractionate protein samples prior to 2-D PAGE using the Gradiflow, which is a new (preparative) electrokinetic membrane apparatus designed to fractionate proteins in a number of different ways. We have fractionated human serum under nonreducing conditions using the 'reflux' mode, in which proteins are fractionated according to their relative mobility under controlled electrophoretic conditions, where the current is periodically reversed. We describe how fractionation occurs and present examples of enrichment of specific proteins.
Dynamic Viscoelasticity of Poly(butyl acrylate) Elastomers Containing Dangling Chains with Controlled Lengths (2011)

We demonstrate that the poly(butyl acrylate) (PBA) elastomers containing considerable amounts of dangling chains with uniform lengths exhibit pronounced viscoelastic relaxation (tan δ > 1) at characteristic frequencies. The elastomers are obtained by the copolymerization of monoacryloyl- and diacryloyl-terminated precursor PBA with narrow size distributions. The molecular weights of the precursors are smaller than the critical molecular weight for the onset of entanglement coupling. The relaxation time of the elastomers (τD) is proportional to the square of the molecular weight of the dangling chains equivalent to the monofunctional PBA (MD), and τD is about 2.5 times larger than the relaxation time of the corresponding free guest chains in the elastomers (τG). These observations are close to the expectations from the Rouse-chain dynamics without entanglement effect (τD ∼ MD2 and τD = 4τG). These results provide an important basis for the understanding of the dynamics of the unentangled chains whose one end is tethered to the permanent networks. The results also offer a route of molecular control of characteristic frequency and strength of mechanical damping of elastomers.
Neuromuscular Organization of the Superior Longitudinalis Muscle in the Human Tongue (2005)

Proper tongue function is essential for respiration and mastication, yet we lack basic information on the anatomical organization underlying human tongue movement. Here we use microdissection, acetylcholinesterase histochemistry, silver staining of nerves, alpha bungarotoxin binding and immunohistochemistry to describe muscle fiber architecture and motor endplate (MEP) distribution of the human superior longitudinalis muscle (SL). The human SL extends from tongue base to tongue tip and is composed of fiber bundles that range from 2.8 to 15.7 mm in length. Individual muscle fibers of the SL range from 1.2 to 17.3 mm in length (1.3-18.2% of muscle length). Seventy-one percent of SL fibers have blunt-blunt terminations; the remainder have blunt-taper terminations. Multiple MEPs are present along SL length and dual MEPs are present on some muscle fibers. These data demonstrate that the human SL is a muscle of "in-series" design. We suggest that SL motor units are organized to innervate specific regions of the tongue body and that activation of SL motor units according to anteroposterior location is one strategy employed by the nervous system to control tongue shape and tongue movement.
The Decca Navigator system for ship and aircraft use (1958)

The paper discusses the present use of the Decca Navigator radio position-fixing system as a marine and aircraft navigational aid. The permanent navigational service currently comprises 12 chains and some 4000 ship and aircraft installations; in addition, mobile chains are used for surveying and exploration. The absence of modulation permits close spacing of the chain frequencies. The receivers contain a reference system giving a common phase datum for all users.The system is a c.w. hyperbolic one in which, in ships, the fixing co-ordinates are normally indicated as phase-meter (Decometer) readings. Aircraft normally use an automatic plotter driven from the receiver by an impulse-motor servo system. There are several different types of airborne receiver, and for certain airborne applications a servo system imparting an inertial characteristic to the displayed data is employed. The system can be combined with a navigational aid of the Doppler type to form the Dian system, and the Dectra long-range aid, also part of Dian, has common ground and airborne equipment with the parent Decca Navigator system. A recent development includes a zone-identification facility and employs a new form of transmission that substantially increases the range at which lane identification is effective at night.
Electrostatic Formation of Liquid Drop in Pin-to-Plate Discharge System (2004)

A preliminary investigation was conducted on electrostatic formation of a liquid drop. High voltage was applied between an insulative capillary tube filled with water and a metal plate electrode. Formation of a water drop was observed at the dark discharge under conditions of appropriate voltage application and water level. Although the electrostatic attractive Coulomb force is small, in the order of 10 μN at the voltage lower than the corona onset, it is large enough to separate the water drop to the capillary tube against surface tension at certain conditions. The diameter of the drop was about one millimeter. At the beginning of corona discharge, however, water mist was dispersed at wide angle from the tip of the tube due to the Coulomb repulsive force of charged mist. When the applied voltage was further icreased, water mist became to be dispersed like spray, because the ionic wind prevented the separation and spread of the droplet. Application of adjusted pulse voltage can form a droplet of which formation is synchronized with the pulse. The diameter of the droplet depended on the applied voltage and the tube diameter. The droplet volume was in the order of several hundred picoliters. Preliminary inkjet printing on a paper was also demonstrated. This phenomenon is expected to be utilized for a new inkjet print head.