gebhart/patrepeval huggingface dataset:
Inhibition of human immunodeficiency virus type 1 reverse transcriptase dimerization using synthetic peptides derived from the connection domain. (1994)

Based on presently available information on the structure of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase, peptides have been synthesized which correspond to the sequence of a particular region of the protein involved in formation of the active heterodimeric form of the enzyme. Several peptides that are 15-19 amino acids long and that are derived from the so-called connection domain of the reverse transcriptase are able to inhibit dimerization of the enzyme and thus inhibit development of its enzymatic activities. In particular, a tryptophan-rich 19-mer corresponding to residues 389-407 was relatively efficient, showing an apparent dissociation constant in the micromolar range for one or both of the subunits. The sequence of this region is identical for both subunits, since one (molecular mass of 51 kDa) is the proteolytic product of the other (molecular mass of 66 kDa). Dissociation of the preformed heterodimer could not be induced by the peptides, but increasing concentrations reduced the rate of dimerization in a concentration-dependent manner until it became immeasurable at high concentrations. The results suggest that inhibition of dimerization of reverse transcriptase is an attractive approach to chemotherapeutic intervention in HIV infection and that further development of peptide-based inhibition strategies is worth pursuing.
Clinical and Immunologic Characteristics of Vibrio cholerae O139 Bengal Infection in North American Volunteers (1995)

Vibrio cholerae O139 Bengal has recently emerged as a cause of epidemic cholera in Asia. To evaluate clinical and immunologic responses to infection, V. cholerae O139 Bengal AI1837 was administered to healthy adult North American volunteers. Two of 4 persons ingesting 10(4) cfu became ill (incubation period, 48 h; mean diarrheal stool, 1873 g), as did 7 of 9 persons receiving 10(6) cfu (incubation period, 28 h; mean diarrheal stool, 4548 g). Ill volunteers did not demonstrate a vibriocidal antibody response to the challenge strain or other V. cholerae. Three months later, volunteers were rechallenged with the homologous O139 Bengal strain. Only 1 of 6 persons who had been ill on initial challenge had diarrhea, compared with 11 of 13 controls (P = .01; protective efficacy = 80%). V. cholerae O139 Bengal can cause severe diarrhea typical of cholera, with clinical characteristics and a dose-response similar to those seen with V. cholerae O1 El Tor. A moderately high level of protection against subsequent disease is provided by initial clinical infection.
Simulating and Visualizing Real-Time Crowds on GPU Clusters (2015)

We present a set of algorithms for simulating and visualizing real-time crowds in GPU (Graphics Processing Units) clusters. First we will present crowd simulation and rendering techniques that take advantage of single GPU machines, then using as an example a wandering crowd behavior simulation algorithm, we explain how this kind of algorithms can be extended for their use in GPU cluster environments. We also present a visualization architecture that renders the simulation results using detailed 3D virtual characters. This architecture is adaptable in order to support the Barcelona Supercomputing Center (BSC) infrastructure. Results show that our algorithms are scalable in different hardware platforms including embedded systems, desktop GPUs and GPU clusters, in particular, the BSC's Minotauro cluster.
Hyper-CVAD Program in Burkitt's-Type Adult Acute Lymphoblastic Leukemia (1999)

Hyper-CVAD is effective in adult B-ALL. Identification of patients with high risk for relapse and improved methods to detect residual disease may result in risk-oriented approaches.
20 Years Advances in Preparation of Potassium Salts from Potassic Rocks: A Review (2015)

Abstract Long‐term research on key techniques of clean utilization of potassic rocks from over twenty localities has been performed to settle the shortage of soluble potassium resources in China. The results show that K‐feldspar as the principal mineral enriched in potassium could be decomposed in the media of Ca(OH) 2 , NaOH, KOH‐H 2 O solution via hydrothermal treatment, into tobermorite, hydroxyl‐cancrinite, and kalsilite respectively. By further processing, these compounds are feasible for being as slow‐release carrier of potassium nitrate, extracting alumina, and preparing farm‐oriented fertilizers of potassium sulphate and nitrate. Correspondingly, the filtrate is KOH, (Na, K) 2 SiO 3 , and K 2 SiO 3 solution, from which potassium carbonate, sulphate, nitrate, and phosphate could be easily fabricated. As NaOH and KOH are recycled in the processing chains by causticizing sodium and/or potassium metasilicate solutions, the hydrothermal alkaline techniques as developed in this research have several advantages as lower consumption of disposable mineral resources and energy, maximized utilization of potassic mineral resources, as well as clean productions etc. Based on the approaches presented in this paper, the technical system of efficiently utilizing insoluble potassium resources has been established. The hydrothermal alkaline methods are feasible to be industrialized on a large scale, thus resulting in decreasing imports of potash fertilizers, improving the pattern of potassium fertilizer consumption, and enhancing the supplying guarantee of potassium resource in China.
Evaluation and Management of Traumatic Lacerations (1997)

Each year in the United States, more than 12 million traumatic wounds are treated in emergency departments.1 When nonemergency or elective incisions are included, approximately 90 million skin-suturing procedures are performed each year.2 Traumatic lacerations occur most often in young men, typically on the face, scalp, and hands.3 More than 50 percent of all lacerations are caused by blunt injury that produces shear forces, and most others by sharp objects, such as metal, glass, and wood.3,4 Only a minority of wounds are caused by mammalian or nonmammalian bites.3 The ultimate goals of wound management are to avoid infection and . . .
Abstract CT066: Global phase 3, randomized, double-blind, placebo-controlled study evaluating PEGylated recombinant human hyaluronidase PH20 (PEGPH20) plus nab-paclitaxel and gemcitabine in patients with previously untreated, hyaluronan (HA)-high, stage IV pancreatic ductal adenocarcinoma (2017)

Abstract Background: Poor outcome in pancreatic ductal adenocarcinoma (PDA) is associated partly with stromal hyaluronan (HA) accumulation, which may compromise chemotherapy access to tumors. In animal models, PEGPH20 degrades HA in tumors. Key endpoint data from a phase 2 study showed that PEGPH20 plus chemotherapy improved efficacy over chemotherapy alone in tumors retrospectively identified to accumulate HA (“HA-High”). The objectives of this phase 3 study are to compare efficacy and safety of standard-dose nab-paclitaxel (NAB) and gemcitabine (GEM) combined with either PEGPH20 or placebo in patients with HA-High, previously untreated, Stage IV PDA. Primary endpoints are progression-free survival (PFS) and overall survival (OS). Secondary endpoints are objective response rate, duration of response, and safety. Methods: 420 patients ≥18 years with untreated HA-High metastatic PDA, ECOG PS 0-1 will be randomized (stratified by geographic region: North America/Europe/Other) 2:1 to NAB 125 mg/m2 + GEM 1000 mg/m2 + PEGPH20 3.0 μg/kg or to placebo. Patients with HA-High tumors will be prospectively identified by the co-developed VENTANA HA RxDx Assay, which indicates HA in the extracellular matrix. HA-High status (indicating patients who may achieve clinical benefit) was determined by Halozyme to be ≥50% staining based on clinical outcome data from a phase 2 study. Treatment will be provided in 4 week cycles (Wk 13, Wk 4 rest) until disease progression, unacceptable toxicity, death, or consent withdrawal. PEGPH20 or placebo will be given twice weekly (Cycle 1) then weekly (Cycles 2+), NAB + GEM once weekly for all cycles. Dexamethasone will be given before and after PEGPH20 administrations to reduce treatment related musculoskeletal symptoms and enoxaparin will be given to minimize thromboembolic events. Tumor response will be assessed by an independent central imaging vendor using RECIST v1.1. Adverse events will be graded per NCI CTCAE v4.03. An independent Data Monitoring Committee will evaluate safety and data for PFS and OS. Trial initiated Q12016 (EudraCT 2015-004068-13; NCT02715804). Citation Format: Lei Zheng, Andrew E. Hendifar, Michele Reni, William P. Harris, Michel Ducreux, Andrea J. Bullock, Pippa G. Corrie, Tara Seery, Dimitrios Chondros, Eric Van Cutsem. Global phase 3, randomized, double-blind, placebo-controlled study evaluating PEGylated recombinant human hyaluronidase PH20 (PEGPH20) plus nab-paclitaxel and gemcitabine in patients with previously untreated, hyaluronan (HA)-high, stage IV pancreatic ductal adenocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr CT066. doi:10.1158/1538-7445.AM2017-CT066
Controversias científicas y repercusiones sociales de la paleontología humana (2008)

Patients diagnosed with acute lumbar disc herniation and severe stenosis due to OYL who present with acute CES warrant emergent surgical decompression to avoid permanent postoperative neurological sequelae.
FORMATION OF HIGHER ALCOHOLS BY VARIOUS YEASTS (1968)

The formation of higher alcohols by various yeasts has been studied as a function of the nitrogen level of the medium. Two types of substrate were used. In one ammonium sulphate was the sole nitrogen source and in the other a complex amino acid mixture simulating that present in brewery wort was used. In the former medium, the patterns exhibited by the yeasts were all very much alike, indicating that the formation of higher alcohols through the biosynthetic activities of yeasts is always basically similar. In the medium containing a complex mixture of amino acids, where the higher alcohols can be formed partly or entirely from the exogenous amino acids through Ehrlich's mechanism, widely different patterns were observed, indicating that the utilization of exogenous amino acids as a source of nitrogen and the extent of regulation of biosynthetic pathways vary with species and strain. All the brewery strains seem to be rather similar and no distinct differences between top and bottom fermentation strains could be observed.
Gene Signature in Melanoma Associated With Clinical Activity (2010)

Immunotherapeutic approaches for melanoma and other cancers can impart profound clinical benefit but only for a subset of patients. Interpatient heterogeneity could, in principle, be due to somatic differences in the tumor between individuals or alternatively be accounted for distinct germline polymorphisms in immunoregulatory genes of the host. Analysis of these possibilities has been initiated by investigating gene expression profiling of the tumor microenvironment in the context of clinical trials of cancer vaccines. Distinct gene expression profiles have been identified on pretreatment biopsies that are associated with a positive or negative clinical outcome. These observations suggest that such profiling might be useful as a predictive biomarker for clinical benefit from vaccines and other immunotherapy approaches, and analysis of specific gene products has begun to suggest new therapeutic interventions to overcome mechanisms of tumor resistance.
Noncompetitive ELISA for human serum insulin-like growth factor-I (1996)

Measurement of serum insulin-like growth factor I (IGF-I) is important in assessing the growth hormone/IGF axis. Competitive immunoassay methods for IGF-I are complicated by substantial interference from IGF-binding proteins (IGFBPs) due to the relatively low ratio of specific antibody to IGFBPs in the sample, even after standard acid-ethanol sample extraction. We report of development of a noncompetitive ELISA for human IGF-I that avoids this problem by utilizing excess amounts of capture and detection antibodies. Serum samples were prepared by using an abbreviated acid-ethanol extraction method. Neutralized supernatant was added to microwells coated with IGF-I capture antibody; horseradish peroxidase-labeled detection antibody was then added, incubated for 2 h, and then developed. Compared with the "gold standard" method of acid-column chromatography, the simplified acid-ethanol extraction yields a mean +/- SD recovery of 103% +/- 5.5% despite the presence of residual IGFBPs in the extracted sample. Comparisons with a centrifugal filtration sample extraction method are also shown. The ELISA is specific for IGF-I with an absolute sensitivity of 0.03 microgram/L and inter- and intraassay CVs of 3.9-8.8% and 2.6-6.7%, respectively. The availability of a rapid IGF-I ELISA combined with a simple and reliable sample preparation procedure should facilitate clinical and research studies of this important growth factor.
Simple, rapid, and accurate determination of deletion mutations by automated dna sequencing of heteroduplex fragments of the adenomatous polyposis coli (APC) gene generated by PCR amplification (1993)

Germline mutations in patients with familial adenomatous polyposis were analyzed by polymerase chain reaction (PCR) amplification of the adenomatous polyposis coli gene. PCR products from heterozygous patients for deletions of this gene formed four distinct bands on polyacrylamide gel electrophoresis. The four fragments were subsequently purified and both strands of each fragment were directly sequenced, using an automated DNA sequencer and the same primers as those for PCR amplification. It was found that the two slower migrating fragments were "bulge" heteroduplexes, while the other two were homoduplexes made up of two wild-type strands and two deletion-mutant strands, respectively. The sites of deletions in the adenomatous polyposis coli gene could be exactly determined in four of the five patients. In an attempt to identify deletion-carriers of familial adenomatous polyposis at the presymptomatic stage, a family study was also carried out, and two children were found to have the same mutations as those of their affected parents. The direct sequencing of heteroduplex fragments generated during PCR amplification is a potentially useful method for detecting mutations of not only the adenomatous polyposis coli gene but also many other genes of genetic diseases.
Visualization of shared system call sequence relationships in large malware corpora (2012)

We present a novel system for automatically discovering and interactively visualizing shared system call sequence relationships within large malware datasets. Our system's pipeline begins with the application of a novel heuristic algorithm for extracting variable length, semantically meaningful system call sequences from malware system call behavior logs. Then, based on the occurrence of these semantic sequences, we construct a Boolean vector representation of the malware sample corpus. Finally we compute Jaccard indices pairwise over sample vectors to obtain a sample similarity matrix. Our graphical user interface links two visualizations within an interactive display. Our first view is a map-like visualization of similarity among the samples based on a reduced dimensional projection of our similarity matrix.
Human high molecular weight-melanoma associated antigen mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: modulation of the immunogenicity in patients with malignant melanoma. (1995)

The mouse anti-idiotypic (anti-id) mAb MK2-23 bears the mirror image of the antigenic determinant defined by antihuman high molecular weight-melanoma associated antigen (HMW-MAA) mAb 763.74. The purpose of this study was to evaluate the effect of conjugation to a carrier and administration with an adjuvant and cyclophosphamide (CTX) on the immunogenicity of anti-id mAb MK2-23 in patients with malignant melanoma and to analyze the relationship between development of humoral immunity and survival time of patients. Fifty-eight patients were sequentially entered into four immunization protocols which included administration of mAb MK2-23, mAb MK2-23 conjugated to keyhole limpet hemocyanin (KLH) and mixed with Bacillus Calmette-Guérin (BCG), mAb MK2-23 and CTX, and mAb MK2-23 conjugated to KLH and mixed with BCG and CTX. Six patients could not be evaluated since they withdrew from the clinical trial after the first immunization. Sera were tested for the development of anti-anti-id antibodies, including those reacting with HMW-MAA. Testing of sera for development of antimouse Ig antibodies was used to monitor the immune competence of patients. Conjugation to KLH and administration with BCG markedly enhanced the ability of mAb MK2-23 to induce anti-anti-id antibodies, including those reacting with HMW-MAA. In contrast, pretreatment with CTX had no detectable effect on the ability of mAb MK2-23 to elicit a humoral anti-anti-id response. Kaplan-Meier survival analysis showed that the performance status of patients, anti-anti-id antibody level, and development of anti-HMW-MAA antibodies had an effect on survival time. This effect was found when the survival time was calculated both from the day of the first immunization and from 4 weeks after the first immunization to the end of the study. A multivariate analysis by Cox regression showed that the development of anti-HMW-MAA antibodies was the most important variable for predicting survival, and that performance status was the only variable that significantly added to the prediction of survival. These data have to be interpreted with caution because of the retrospective nature of the analysis. Nevertheless, the present study suggests that mAb MK2-23 represents a useful immunogen to implement active, specific immunotherapy in patients with malignant melanoma.
Cutting Edge: A Novel Chemokine Ligand for CCR10 And CCR3 Expressed by Epithelial Cells in Mucosal Tissues (2000)

Mucosae-associated epithelial chemokine (MEC) is a novel chemokine whose mRNA is most abundant in salivary gland, with strong expression in other mucosal sites, including colon, trachea, and mammary gland. MEC is constitutively expressed by epithelial cells; MEC mRNA is detected in cultured bronchial and mammary gland epithelial cell lines and in epithelia isolated from salivary gland and colon using laser capture microdissection, but not in the endothelial, hemolymphoid, or fibroblastic cell lines tested. Although MEC is poorly expressed in skin, its closest homologue is the keratinocyte-expressed cutaneous T cell-attracting chemokine (CTACK; CCL27), and MEC supports chemotaxis of transfected lymphoid cells expressing CCR10, a known CTACK receptor. In contrast to CTACK, however, MEC also supports migration through CCR3. Consistent with this, MEC attracts eosinophils in addition to memory lymphocyte subsets. These results suggest an important role for MEC in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs.
Multicolor digital holography with an achromatic phase shifter (2002)

Multiwavelength recording and reconstruction of a three-dimensional object are realized by use of phase-shifting digital holography. Red, green, and blue lines emitted from a white-light He-Cd laser are used for one-step recording of the complex amplitude of the object with a color CCD camera, in which a phase shift is introduced with an achromatic phase shifter based on the geometric phase. Three color images are reconstructed and successfully combined in a computer by use of Fresnel transformation based on a convolution.
Type-directed completion of partial expressions (2012)

Modern programming frameworks provide enormous libraries arranged in complex structures, so much so that a large part of modern programming is searching for APIs that surely exist" somewhere in an unfamiliar part of the framework. We present a novel way of phrasing a search for an unknown API: the programmer simply writes an expression leaving holes for the parts they do not know. We call these expressions partial expressions. We present an efficient algorithm that produces likely completions ordered by a ranking scheme based primarily on the similarity of the types of the APIs suggested to the types of the known expressions. This gives a powerful language for both API discovery and code completion with a small impedance mismatch from writing code. In an automated experiment on mature C# projects, we show our algorithm can place the intended expression in the top 10 choices over 80% of the time.
Nanofibers from Natural and Inorganic Polymers via Electrospinning (2005)

In the present work the formation of nanofibre webs from natural polymers accessible from waste materials and SiO 2 -precursors was studied at environmentally acceptable electro-spinning conditions, thus excluding the use of hazardous organic solvents for the preparation of spinning solutions. For these purposes water-based solutions of S-sulfo-kerateins isolated from wool, chitosan and precondensated tertraethyl orthosilicate were investigated with special regard to their propensity in nanofibre formation.
Prediction of Clothing Thermal Insulation and Moisture Vapour Resistance of the Clothed Body Walking in Wind (2006)

Clothing thermal insulation and moisture vapour resistance are the two most important parameters in thermal environmental engineering, functional clothing design and end use of clothing ensembles. In this study, clothing thermal insulation and moisture vapour resistance of various types of clothing ensembles were measured using the walking-able sweating manikin, Walter, under various environmental conditions and walking speeds. Based on an extensive experimental investigation and an improved understanding of the effects of body activities and environmental conditions, a simple but effective direct regression model has been established, for predicting the clothing thermal insulation and moisture vapour resistance under wind and walking motion, from those when the manikin was standing in still air. The model has been validated by using experimental data reported in the previous literature. It has shown that the new models have advantages and provide very accurate prediction.
Retardation of Brain Aging by Chronic Treatment with Melatonin (2004)

Slowing the functional decline in the aging brain is not only relevant to nonpathological senescence but also to a broad range of neurodegenerative diseases. Although disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD) are not found in the young adult, they gradually manifest with increasing age. AD, in particular, is an increasing major public health concern as the population ages; therapies that delay disease onset will markedly reduce overall disease prevalence. Aging of the brain has been repeatedly associated with cumulative oxidative damage to macromolecules and to abnormal levels of inflammatory activity. Melatonin has attained increasing prominence as a candidate for ameliorating these changes occurring during senescence. Recent research has focused on supplementation with dietary melatonin designed to elucidate the specific key intracellular targets of age-related inflammatory events, and the optimal means of affording protection of these targets. This report summarizes the progress made in this area.