gebhart/patrepeval huggingface dataset:
Bupropion Augmentation in the Treatment of Chronic Fatigue Syndrome with Coexistent Major Depression Episode (2006)

While psychoeducational strategies and general support are always indicated for the treatment of chronic fatigue syndrome (CFS), pharmacological strategies are yet not well established. Antidepressants such as selective serotonin re-uptake inhibitors have been shown to influence positively symptoms and immunological parameters. However, a considerable part of CFS patients do not satisfactorily respond to them. Bupropion, a centrally acting catecholamine-transporter blocker without classic psycho-analeptic properties, shows theoretical potential to improve fatigue symptoms. In the reported case paroxetine was augmented with bupropion at high dosage, a strategy which consecutively led to a rapid relief of CFS-symptoms.
Intraindividual variability in cognitive performance in three groups of older adults: Cross-domain links to physical status and self-perceived affect and beliefs (2002)

Intraindividual variability of physical status and affect/beliefs as well as their relations with cognition were examined in 3 groups of older adults: healthy elderly, individuals with a nonneurological health-related disturbance (arthritis) and people with neurological compromise (dementia). The findings showed that greater inconsistency in physical performance was observed in groups characterized by central nervous system dysfunction. By contrast, fluctuations in affect appeared to reflect other more transient sources, such as pain. In general, increased inconsistency in non-cognitive domains was associated with poorer cognitive function. There were cross-domain links between inconsistency in physical functioning and fluctuations in cognitive performance, although the nature of the links depended largely upon the neurological status of the individuals. Considered together, the result indicated that measures of cognitive as well as physical variability are important behavioral markers of neurological integrity.
Ciliary resorption modulates G1length and cell cycle progression (2011)

Comment on: Li A, et al. Nat Cell Biol 2011; 13:402-11.
Dynamics of Gas−Surface Interactions:  Reaction of Atomic Oxygen with Chemisorbed Hydrogen on Tungsten (1997)

The reaction of gas-phase atomic oxygen with hydrogen atoms chemisorbed on a tungsten surface is studied by means of classical trajectory procedures. Flow of energy between the reaction zone and the bulk solid phase is treated in the generalized Langevin equation approach. Most reactive events occur in small-impact-parameter collisions, in which the incident gas atom undergoes only one impact with the adatom, producing vibrationally excited OH radicals on a subpicosecond scale via the Eley−Rideal mechanism. Short-time calculations show that, in these collisions, the formation of the OH bond and subsequent dissociation of the H−surface bond occur in ∼100 fs. A small fraction of reactive events occurs in a multiple-impact collision, forming a long-lived complex on the surface. As the impact parameter increases, both reaction probability and vibrational excitation decrease, thus producing a population inversion. The dissipation of reaction energy to the heat bath can be adequately described using a 10-atom chain with the chain end bound to the rest of the solid. The probability of OH(g) formation is not sensitive to the variation of surface temperatures between 0 and 300 K, whereas it rapidly rises with the gas temperature up to 1000 K, above which it remains nearly constant. A modified LEPS potential energy surface is used for the reaction zone interaction, whereas the framework of harmonic representation is used in modeling chain atoms.
The isolation and characterization of cDNA clones for human apolipoprotein CII. (1984)

Recombinant clones containing cDNA sequences coding for human apolipoprotein CII have been isolated from a human adult liver cDNA library. The clones were detected by hybridization with a mixed probe consisting of 96 different oligonucleotides 17 bases long, complementary to the mRNA coding for amino acids 66 to 71 of apolipoprotein CII. The largest cDNA insert is 439 nucleotides long and contains the complete sequence for the mature protein, the 3' untranslated sequence, and sequence coding for 17 amino acids of a signal peptide. The cDNA clone was used to detect apolipoprotein CII mRNA approximately 500 bases long in human liver and intestine RNA.
Scale-out NUMA (2014)

Emerging datacenter applications operate on vast datasets that are kept in DRAM to minimize latency. The large number of servers needed to accommodate this massive memory footprint requires frequent server-to-server communication in applications such as key-value stores and graph-based applications that rely on large irregular data structures. The fine-grained nature of the accesses is a poor match to commodity networking technologies, including RDMA, which incur delays of 10-1000x over local DRAM operations. We introduce Scale-Out NUMA (soNUMA) -- an architecture, programming model, and communication protocol for low-latency, distributed in-memory processing. soNUMA layers an RDMA-inspired programming model directly on top of a NUMA memory fabric via a stateless messaging protocol. To facilitate interactions between the application, OS, and the fabric, soNUMA relies on the remote memory controller -- a new architecturally-exposed hardware block integrated into the node's local coherence hierarchy. Our results based on cycle-accurate full-system simulation show that soNUMA performs remote reads at latencies that are within 4x of local DRAM, can fully utilize the available memory bandwidth, and can issue up to 10M remote memory operations per second per core.
A novel sRNA component of the carbon storage regulatory system of Escherichia coli (2003)

Small untranslated RNAs (sRNAs) perform a variety of important functions in bacteria. The 245 nucleotide sRNA of Escherichia coli, CsrC, was discovered using a genetic screen for factors that regulate glycogen biosynthesis. CsrC RNA binds multiple copies of CsrA, a protein that post-transcriptionally regulates central carbon flux, biofilm formation and motility in E. coli. CsrC antagonizes the regulatory effects of CsrA, presumably by sequestering this protein. The discovery of CsrC is intriguing, in that a similar sRNA, CsrB, performs essentially the same function. Both sRNAs possess similar imperfect repeat sequences (18 in CsrB, nine in CsrC), primarily localized in the loops of predicted hairpins, which may serve as CsrA binding elements. Transcription of csrC increases as the culture approaches the stationary phase of growth and is indirectly activated by CsrA via the response regulator UvrY. Because CsrB and CsrC antagonize CsrA activity and depend on CsrA for their synthesis, a csrB null mutation causes a modest compensatory increase in CsrC levels and vice versa. Homologues of csrC are apparent in several Enterobacteriaceae. The regulatory and evolutionary implications of these findings are discussed.
Two signaling schemes for improving the error performance of frequency-division-duplex (FDD) transmission systems using transmitter antenna diversity (2002)

Two signaling schemes that exploit the availability of multiple (N) antennas at the transmitter to provide diversity benefit to the receiver are proposed. In the first scheme, a channel code of length N and minimum Hamming distance d/sub min/ /spl les/ N is used to encode a group of K information bits. The channel code symbol c/sub i/ is transmitted with the i/sup th/ antenna. At the receiver, a maximum likelihood decoder for the channel code provides a diversity of d/sub min/, as long as each transmitted code symbol is subjected to independent fading. The second scheme introduces deliberate resolvable multipath distortion by transmitting the data bearing signal with antenna 1, and N - 1 delayed versions of it with antennas 2 through N. The delays are unique to each antenna and are chosen to be multiples of the symbol interval. At the receiver, a maximum likelihood sequence estimator resolves the multipath in an optimal manner to realize a diversity benefit of N.
Isolation and characterization of two distinct forms of protein kinase C. (1987)

Protein kinase C (Ca2+- and phospholipid-dependent protein kinase) has been purified from rat brain by a three-step, 18-h procedure resulting in the isolation of milligram quantities of enzyme. Unlike previous preparations from published protocols, which yield a single polypeptide, this procedure yields a protein which consists of a 78/80-kDa doublet upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The two polypeptides have been characterized with respect to structure and function and are very similar in both regards. However, the two forms can be distinguished immunologically by polyclonal antisera generated against purified protein kinase C. The 78- and 80-kDa proteins do not appear to be related to one another by proteolytic cleavage or by differential phosphorylation, although the two purified proteins do contain stoichiometric amounts of phosphate. The 78- and 80-kDa polypeptides therefore appear to represent two distinct forms of protein kinase C, thus providing evidence for the existence of multiple isozymes of this key regulatory protein.
Stable supercontinuum generation in short lengths of conventional dispersion-shifted fiber (1999)

By propagating 500-fs pulses through 2.5 m of standard fiber followed by 2 m of dispersion-shifted fiber, we generated >200 nm of spectral continuum between 1430 and 1630 nm, which is flat to less than ?0.5 dB over more than 60 nm. Pulses obtained by filtering the continuum show no increase in timing jitter over the source laser and are pedestal free to >28 dB, indicating excellent stability and coherence. We show that the second- and third-order dispersions of the continuum fiber and self-phase modulation are primarily responsible for the continuum generation and spectral shaping and found close agreement between simulations and experiments.
Rapid and effective labeling of brain tissue using TAT-conjugated CdS∶Mn/ZnS quantum dots (2005)

TAT (a cell penetrating peptide)-conjugated CdSratioMn/ZnS quantum dots (Qdots), intra-arterially delivered to a rat brain, rapidly (within a few minutes) labeled the brain tissue without manipulating the blood-brain-barrier (BBB). Qdot loading was sufficiently high that it allowed a gross fluorescent visualization of the whole rat brain using a low power hand-held UV lamp. Histological data clearly showed that TAT-conjugated Qdots migrated beyond the endothelial cell line and reached the brain parenchyma. Qdots without TAT did not label the brain tissue confirming the fact that TAT peptide was necessary to overcome the BBB. The present study clearly demonstrated the possibility of delivering a large amount of Qdot-based imaging agents to the brain tissue.
Liquid deposition photolithography for submicrometer resolution three-dimensional index structuring with large throughput (2013)

Photonic devices increasingly require three-dimensional control of refractive index, but existing fabrication methods such as femtosecond micromachining, multilayer lithography and bulk diffusion can only address a select scale range, are often limited in complexity or thickness and have low throughput. We introduce a new fabrication method and polymeric material that can efficiently create mm3 optical devices with programmable, gradient index of refraction with arbitrary feature size. Index contrast of 0.1 is demonstrated, which is 100 times larger than femtosecond micromachining, and 20 times larger than commercial holographic photopolymers. This is achieved by repetitive microfluidic layering of a self-developing photopolymer structured by projection lithography. The process has the unusual property that total fabrication time for a fixed thickness decreases with the number of layers, enabling fabrication 105 faster than femtosecond micromachining. We demonstrate the process by sequentially writing 100 layers to fabricate a mm thick waveguide array. A photolithography scheme for making polymer-based photonic circuitry can be used to create complex 3D devices with large refractive index contrasts. Adam Urness and co-workers from the University of the USA say that their ‘liquid deposition photolithography’ approach can rapidly create millimetre-scale structures with submicrometre resolution and refractive index contrasts of up to 0.1. The scheme works by projecting a pattern of ultraviolet (365 nm) light onto a layer of a liquid photosensitive polymer that solidifies into a gel upon exposure. Regions that receive greater light intensity have a higher density and refractive index. The process can be repeated with many layers to create large, complex structures. For example, the team has used their approach to fabricate miniature logos, waveguide arrays and photonic crystal fibres.
α-Dialkylamino acid transaminase from Pseudomonas cepacia. Purification, crystallization, physical, and kinetic properties (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTα-Dialkylamino acid transaminase from Pseudomonas cepacia. Purification, crystallization, physical, and kinetic propertiesC. A. Lamartiniere, Hajime Itoh, and Walter B. DempseyCite this: Biochemistry 1971, 10, 25, 4783–4788Publication Date (Print):December 7, 1971Publication History Published online1 May 2002Published inissue 7 December 1971https://pubs.acs.org/doi/10.1021/bi00801a028https://doi.org/10.1021/bi00801a028research-articleACS PublicationsRequest reuse permissionsArticle Views51Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Immunomodulatory Effects of <i>Lactobacillus</i> and <i>Bifidobacterium </i>on Both Murine and Human Mitogen-Activated T Cells (2011)

Dose selection is an important issue for probiotic studies. Our results indicated that probiotics have beneficial effects on regulating T cell-mediated immune responses by attenuating mitogen-induced overactive immune responses and promoting Th1 immune responses.
Fidelity of the reverse transcriptase of human immunodeficiency virus type 2 (1992)

The relatively low fidelity of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) was implicated as a major factor that contributes to the genetic variability of the virus. Extension of mismatched 3' termini of the primer DNA was shown to be a major determinant of the infidelity of HIV-1 RT. Human immunodeficiency virus type 2 (HIV-2) also shows extensive genetic variations. Therefore, we have analyzed the fidelity of the DNA-dependent DNA polymerase activity of HIV-2 RT and compared it with those of RTs of HIV-1 and murine leukemia virus (MLV). Like other retroviral RTs, the HIV-2 RT was shown to lack a 3'----5' exonuclease activity. The ability of HIV-2 RT to extend preformed 3'-terminal A:A, A:C and A:G mispairs was examined by quantitating the amount and length of extended primers. The results demonstrate a relatively efficient mispair extension by HIV-2 RT with a specificity of A:C much greater than A:A greater than A:G. The mispair extension appears to be affected mainly by the increase of apparent Km values rather than by the change in Vmax values. The relative extension frequencies from all mispairs with HIV-1 and HIV-2 RTs was 6- to 9-fold greater than that of MLV RT, suggesting that the HIV enzymes are substantially more error-prone than MLV RT.
Evaluating Humidity Recovery Efficiency of Currently Available Heat and Moisture Exchangers: A Respiratory System Model Study (2009)

Our data indicate that heat and moisture exchangers are more efficient when used with low tidal volume ventilation. The roles of flow and respiratory rate were of lesser importance, suggesting that their adjustment has a less significant effect on the performance of heat and moisture exchangers.
Interferon-a2b Reduces Neo-Microvascular Density in the ‘Normal’ Urothelium Adjacent to the Tumor after Transurethral Resection of Superficial Bladder Carcinoma (2003)

Our results show that the intravesical administration of IFN-a2b after TUR significantly decreases the angiogenic potential of the 'healthy' urothelium adjacent to the tumor in patients with TCC. This observation could possibly explain, to a certain extent, the mechanism by which IFN-a2b reduces the recurrence rate of primary TCC.
Can Dementia Be Prevented? Brain Aging in a Population-Based Context (2004)

As a consequence of global aging of the human population, the occurrence of cognitive impairment and dementia is rapidly becoming a significant burden for medical care and public health systems. By the year 2020, the WHO predicts there will be nearly 29 million demented people in both developed and developing countries. Primary and secondary prevention of dementia through individual and population-level interventions could reduce this imminent risk. Vascular risk factors such as type 2 diabetes, hypertension, dietary fat intake, high cholesterol, and obesity have emerged as important influences on the risk of both vascular and Alzheimer's dementia. Understanding the reasons for differences between populations in genetic vulnerability and environmental exposures may help to identify modifiable risk factors that may lead to effective prevention of vascular and Alzheimer's dementia.
Listeria monocytogenes bile salt hydrolase is a PrfA‐regulated virulence factor involved in the intestinal and hepatic phases of listeriosis (2002)

Listeria monocytogenes is a bacterial pathogen causing severe food-borne infections in humans and animals. It can sense and adapt to a variety of harsh microenvironments outside as well as inside the host. Once ingested by a mammalian host, the bacterial pathogen reaches the intestinal lumen, where it encounters bile salts which, in addition to their role in digestion, have antimicrobial activity. Comparison of the L. monocytogenes and Listeria innocua genomes has revealed the presence of an L. monocytogenes-specific putative gene encoding a bile salt hydrolase (BSH). Here, we show that the bsh gene encodes a functional intracellular enzyme in all pathogenic Listeria species. The bsh gene is positively regulated by PrfA, the transcriptional activator of known L. monocytogenes virulence genes. Moreover, BSH activity increases at low oxygen concentration. Deletion of bsh results in decreased resistance to bile in vitro, reduced bacterial faecal carriage after oral infection of the guinea-pigs, reduced virulence and liver colonization after intravenous inoculation of mice. Taken together, these results demonstrate that BSH is a novel PrfA-regulated L. monocytogenes virulence factor involved in the intestinal and hepatic phases of listeriosis.
Identification of CCR6, the Specific Receptor for a Novel Lymphocyte-directed CC Chemokine LARC (1997)

Liver and activation-regulated chemokine (LARC) is a recently identified CC chemokine that is expressed mainly in the liver. LARC functions as a selective chemoattractant for lymphocytes that express a class of receptors specifically binding to LARC with high affinity. To identifiy the receptor for LARC, we examined LARC-induced calcium mobilization in cells stably expressing five CC chemokine receptors (CCR1-CCR5) and five orphan seven-transmembrane receptors. LARC specifically induced calcium flux in K562 cells as well as 293/EBNA-1 cells stably expressing an orphan receptor GPR-CY4. LARC induced migration in 293/EBNA-1 cells stably expressing GPR-CY4 with a bi-modal dose-response curve. LARC fused with secreted alkaline phosphatase (LARC-SEAP) bound specifically to Raji cells stably expressing GPR-CY4 with a Kd of 0.9 nM. Only LARC but not five other CC chemokines (MCP-1, RANTES, MIP-1alpha, MIP-1beta, and TARC) competed with LARC-SEAP for binding to GPR-CY4. By Northern blot analysis, GPR-CY4 mRNA was expressed mainly in spleen, lymph nodes, Appendix, and fetal liver among various human tissues. Among various leukocyte subsets, GPR-CY4 mRNA was detected in lymphocytes (CD4(+) and CD8(+) T cells and B cells) but not in natural killer cells, monocytes, or granulocytes. Expression of GPR-CY4 mRNA in CD4(+) and CD8(+) T cells was strongly up-regulated by IL-2. Taken together, GPR-CY4 is the specific receptor for LARC expressed selectively on lymphocytes, and LARC is a unique functional ligand for GPR-CY4. We propose GPR-CY4 to be designated as CCR6.
Miniature fiber-optic pressure sensor with a polymer diaphragm (2005)

The fabrication and experimental investigation of a miniature optical fiber pressure sensor for biomedical and industrial applications are described. The sensor measures only 125 microm in diameter. The essential element is a thin polymer diaphragm that is positioned inside the hollow end of an optical fiber. The cavity at the fiber end is made by a simple and effective micromachining process based on wet etching in diluted HF acid. Thus a Fabry-Perot interferometer is formed between the inner fiber-cavity interface and the diaphragm. The fabrication technique is described in detail. Different sensor prototypes were fabricated upon 125 microm-diameter optical fiber that demonstrated pressure ranges from 0 to 40 and from 0 to 1200 kPa. A resolution of less than 10 Pa was demonstrated in practice. The fabrication technique presented facilitates production of simple and low-cost disposable pressure sensors by use of materials with that ensure the required biocompatibility.
A Downlink Max-SINR Precoding for Massive MIMO System (2014)

To acquire the maximal array gain and mitigate the impact of pilot contamination, the downlink precoding algorithm on Max-SINR criterion was investigated and improved for Massive MIMO system. The objective function assured to maximize the utilization rate of the transmission power under the condition that SINR is not lower than the desired threshold. The Lagrangian function was deduced according to the objective function. Further SINR computation counted the channel estimation error caused by pilot contamination and its computational complexity was reduced by utilizing the character of Massive MIMO channel. At last the optimal downlink precoding matrix was obtained by KKT conditions. When base station configured 100 antennas and the pilot contamination was severe, numerical results proved that the spectrum efficiency of the proposed algorithm was 1.9 times higher than the popular Massive MIMO precoding ---MF algorithm. The proposed algorithm can effectively mitigate the impact of pilot contamination and achieve high throughput with maximizing gain, and is valuable to Massive MIMO system.
Monkey bone matrix induces bone formation in the athymic rat, but not in adult monkeys (1991)

Abstract Demineralized bone matrix from young and adult monkeys was implanted intramuscularly for 6 weeks in athymic rats and adult monkeys. Cartilage and bone induction was evaluated by histology and calcium content. In the athymic rat, most implants induced cartilage or bone. In the monkeys, cartilage was formed only on rare occasions and there was no sign of bone formation. We conclude that (a) adult monkey bone matrix contains bone inductive properties; (b) these properties are not sufficient to induce bone formation in adult monkey muscle sites.