gebhart/patrepeval huggingface dataset:
Antioxidant Status in Persons With and Without Senile Cataract (1988)

The relationship between biochemical markers of antioxidant status and senile cataract was examined in 112 subjects aged 40 to 70 years. Seventy-seven of these subjects had a cataract in at least one lens. Antioxidant status was measured using erythrocyte superoxide dismutase, glutathione peroxidase, and glucose-6-phosphate dehydrogenase activity, and indexes that included these enzymes plus plasma levels of vitamin E, vitamin C, and carotenoids. Subjects were grouped by level (low, moderate, or high) of the enzymes and antioxidant indexes. Results suggest that subjects with high levels of at least two of the three vitamins (vitamin E, vitamin C, or carotenoids) are at reduced risk of cataract relative to subjects with low levels of one or more of these vitamins (odds ratio, 0.2). The erythrocyte enzymes, either individually or in combination, did not appear to differ between subjects with and without cataract.
Effect of Cyclin D1 Overexpression on Drug Sensitivity in a Human Fibrosarcoma Cell Line (1996)

These results indicate that alterations in cell cycle genes may differ in their effects on cytotoxicity. It will be important to determine the effects of alterations of other cell cycle regulatory genes on the responses of cells to specific classes of drugs. Tumors with overexpression of cyclin D1 may be relatively refractory to methotrexate treatment.
DEAMON: Energy-efficient Sensor Monitoring (2009)

In people-centric opportunistic sensing, people offer their mobile nodes (such as smart phones) as platforms for collecting sensor data. A sensing application distributes sensing 'tasks', which specify what sensor data to collect and under what conditions to report the data back to the application. To perform a task, mobile nodes may use on-board sensors, a body-area network of personal sensors, or sensors from neighboring nodes that volunteer to contribute their sensing resources. In all three cases, continuous sensor monitoring can drain a node's battery. We propose DEAMON (Distributed Energy-Aware MONitoring), an energy-efficient distributed algorithm for long-term sensor monitoring. Our approach assumes only that mobile nodes are tasked to report sensor data under conditions specified by a Boolean expression, and that a network of nearby sensor nodes contribute to monitoring subsets of the task's sensors. Our algorithm to select sensor nodes and to monitor the sensing condition conserves energy of all nodes by limiting sensing and communication operations. We evaluate DEAMON with a stochastic analysis and with simulation results, and show that it should significantly reduce energy consumption.
On the chemistry of binding sites VII. Enantioselective binding using chiral boronic acids (1990)

Abstract For the construction of chiral binding sites in chromatography, various phenylboronic acids have been prepared as model substances carrying, in the ortho ( 3a‐d ) or ortho, ortho position ( 4a‐d ), optically active side‐groups containing basic nitrogen atoms. The compound carrying two prolyl residues shows the highest selectivity in chiral recognition of racemic diols (separation factor α between 1.70‐2.25). Separation occurs via the formation of a cyclic boronic diester of the diol. The thermodynamic properties of this esterification reaction are well suited to chromatography and furthermore the reaction seems to be adequately rapid.
Senescence-associated lncRNAs: senescence-associated long noncoding RNAs (2013)

Noncoding RNAs include small transcripts, such as microRNAs and piwi-interacting RNAs, and a wide range of long noncoding RNAs (lncRNAs). Although many lncRNAs have been identified, only a small number of lncRNAs have been characterized functionally. Here, we sought to identify lncRNAs differentially expressed during replicative senescence. We compared lncRNAs expressed in proliferating, early-passage, 'young' human diploid WI-38 fibroblasts [population doubling (PDL) 20] with those expressed in senescent, late-passage, 'old' fibroblasts (PDL 52) by RNA sequencing (RNA-Seq). Numerous transcripts in all lncRNA groups (antisense lncRNAs, pseudogene-encoded lncRNAs, previously described lncRNAs and novel lncRNAs) were validated using reverse transcription (RT) and real-time, quantitative (q)PCR. Among the novel senescence-associated lncRNAs (SAL-RNAs) showing lower abundance in senescent cells, SAL-RNA1 (XLOC_023166) was found to delay senescence, because reducing SAL-RNA1 levels enhanced the appearance of phenotypic traits of senescence, including an enlarged morphology, positive β-galactosidase activity, and heightened p53 levels. Our results reveal that the expression of known and novel lncRNAs changes with senescence and suggests that SAL-RNAs play direct regulatory roles in this important cellular process.
WearTrack: a self-referenced head and hand tracker for wearable computers and portable VR (2002)

This paper presents a new tracking technique which is essentially "sourceless" in that it can be used anywhere with no set-up, yet it enables a much wider range of virtual environment-style navigation and interaction techniques than does a simple head-orientation tracker. The new system is based on the very simple idea of combining a sourceless head orientation tracker with a head-worn tracking device that tracks a hand-mounted 3D beacon relative to the head. Because the seen graphical representation of the pointer accurately matches the felt hand position despite any errors in the orientation tracker, the system encourages use of intuitive interaction techniques which exploit proprioception. We describe a prototype of the tracking system, and discuss and demonstrate its application in a portable VR system and in a wearable computer user interface.
Amino acid sequence elucidation of human acrosin‐trypsin inhibitor (HUSI‐II) reveals that Kazal‐type proteinase inhibitors are structurally related to β‐subunits of glycoprotein hormones (1990)

The amino acid sequence of the acrosin-trypsin inhibitor HUSI-II from human seminal plasma is presented which unequivocally identifies HUSI-II as being of Kazal-type. In addition, the HUSI-II sequence shows a striking similarity to the middle part of glycoprotein hormone beta-subunits thus revealing a hitherto unknown structural and evolutionary relationship between Kazal-type inhibitors and glycoprotein hormones.
Temporal Trends in Ischemic Heart Disease Mortality in 21 World Regions, 1980 to 2010 (2014)

In most world regions, particularly in high-income regions, age-standardized IHD mortality rates have declined significantly since 1980. High age-standardized IHD mortality in Eastern Europe, Central Asia, and South Asia point to the need to prevent and control established risk factors in those regions and to research the unique behavioral and environmental determinants of higher IHD mortality.
CLONING AND INDUCED DIFFERENTIATION OF ADULT GOAT SKIN STEM CELLS IN VITRO (2003)

Objective To establish a good method and culture system to isolate skin stem cell and expand it in vitro so as to lay a foundation for exploring the proliferation and differentiation mechanism of skin stem cell. Methods Skin stem cells were obtained by explant culture and identified by using alkaline phosphatase(ALP) staining and differentiating experiment in vitro. Stem cell was induced by the cocktail of conditional medium with cell growth factor (insulin like growth factor and epidermal growth factor). Results Skin stem cell colonies were derived from ear skin tissues of adult dairy goats. The colonies had some characteristics of embryonic stem cells, such as the ability to be continuously passaged (Passage 5) and the morphology nest like. They continued to be ALP positive and had the capacity of forming embryoid bodies. These cells were pluripotent and stem like cells. In vitro these stem cell can be induced to be Follicle like structure, Astrocyte like cells, osteoblast like cell. Conclusion Explant culture is a good method to isolate skin stem cell, which can be induced to be committed differentiation and trans differentiation.
[Tamoxifen in the treatment of breast cancer]. (1994)

Tamoxifen is the most often prescribed non steroidal antioestrogenic agent in the world for breast cancer. Worldwide collaboration. has centralized the results, of different trials throughout the world on oral adjuvant therapy in the early stages of breast cancer. A significative regression of the tumour was observed in most cases. Moreover, recent epidemiological studies suggest that tamoxifen could prevent new contralateral primary tumours. The risk of the disease should thus be reduced by the prophylactic use of antioestrogens such as tamoxifen. Investigations using a variety of models have evaluated the effect of tamoxifen on tumour promotion and cell growth. Tamoxifen-induced growth inhibition is associated with major changes in biochemical events in cultured human breast cancer cells including cell proliferation or growth factor production. Growth inhibition of oestrogen-responsive human breast cancer cells is associated with an induced secretion of autoinhibitory polypeptides (TGF beta) and an antagonistic effect on the synthesis of proliferative proteins (TGF alpha,...). The first step in the mechanism of action of the drug is binding of tamoxifen to the oestrogen receptors. Development of resistance to tamoxifen treatment is a great problem in treatment of breast cancer patients and the mechanism of resistance will require further study: under the influence of the drug, tumours could become remodelled as selected subpopulations emerge resistant-tamoxifen. The fact that some breast cancers which are oestrogen receptor-negative respond to antioestrogen suggests that parallel but separate pathways for oestrogen and antioestrogen action may exist. This paper summarizes the results of the most recent studies concerning this promising drug.
Inhibition of protein synthesis blocks long-term enhancement of generator potentials produced by one-trial in vivo conditioning in Hermissenda. (1990)

A one-trial in vivo conditioning procedure produces short- and long-term cellular changes that can be detected in identified sensory neurons of the pathway mediating the conditioned stimulus. The memory of the associative experience in the conditioned stimulus pathway is expressed by short- and long-term enhancement of light-evoked generator potentials recorded from identified lateral and medial type B photoreceptors within the eyes of Hermissenda. To identify mechanisms of the induction and expression of short- and long-term enhancement in identified photoreceptors, we have investigated the effects of inhibiting protein synthesis during the application of the one-trial in vivo conditioning procedure. Anisomycin (1 microM) present during and after the conditioning trial blocked long-term enhancement without affecting the induction or expression of short-term enhancement. Application of a control compound, deacetylanisomycin (1 microM), or delaying the application of anisomycin until 1 hr after the conditioning trial did not block either long- or short-term enhancement. These results indicate that synthesis of proteins during or shortly after training may be a critical step in the formation of long-term memory of the associative experience.
Nonlabeled Quartz Crystal Microbalance Biosensor for Bacterial Detection Using Carbohydrate and Lectin Recognitions (2007)

High percentages of harmful microbes or their secreting toxins bind to specific carbohydrate sequences on human cells at the recognition and attachment sites. A number of studies also show that lectins react with specific structures of bacteria and fungi. In this report, we take advantage of the fact that a high percentage of microorganisms have both carbohydrate and lectin binding pockets at their surface. We demonstrate here for the first time that a carbohydrate nonlabeled mass sensor in combination with lectin-bacterial O-antigen recognition can be used for detection of high molecular weight bacterial targets with remarkably high sensitivity and enhanced specificity. A functional mannose self-assembled monolayer in combination with lectin concanavalin A (Con A) was used as molecular recognition elements for the detection of Escherichia coli W1485 using a quartz crytsal microbalance (QCM) as a transducer. The multivalent binding of Con A to the E. coli surface O-antigen favors the strong adhesion of E. coli to the mannose-modified QCM surface by forming bridges between these two. As a result, the contact area between cell and QCM surface that increases leads to rigid and strong attachment. Therefore, it enhances the binding between E. coli and the mannose. Our results show a significant improvement of the sensitivity and specificity of the carbohydrate QCM biosensor with a experimental detection limit of a few hundred bacterial cells. The linear range is from 7.5 x 10(2) to 7.5 x 10(7) cells/mL, which is four decades wider than the mannose-alone QCM sensor. The change of damping resistances for E. coli adhesion experiments was no more than 1.4%, suggesting that the bacterial attachment was rigid, rather than a viscoelastic behavior. Little nonspecific binding was observed for Staphylococcus aureus and other proteins (fetal bovine serum, Erythrina cristagalli lectin). Our approach not only overcomes the challenges of applying QCM technology for bacterial detection but also increases the binding of bacteria to their carbohydrate receptor through bacterial surface binding lectins that significantly enhanced specificity and sensitivity of QCM biosensors. Combining carbohydrate and lectin recognition events with an appropriate QCM transducer can yield sensor devices highly suitable for the fast, reversible, and straightforward on-line screening and detection of bacteria in food, water, and clinical and biodefense areas.
Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets. (1985)

The ability of exogenous sn-1,2-diacylglycerols and analogs to function as bioregulators of protein kinase C in human platelets was investigated. The activation of protein kinase C in platelets is indicated by specific phosphorylation of a 40,000-dalton protein. Dihexanoylglycerol, dioctanoylglycerol (diC8), didecanoylglycerol, and sn-1-oleoyl-2-acetylglycerol were active in stimulating 40,000-dalton protein phosphorylation. Only a trace of phosphorylation was elicited by dibutyrylglycerol. Phosphorylation was not induced by analogs of diC8 in which an -H, -SH, or -Cl group replaced the free -OH, nor by monoacylglycerols or long chain diacylglycerols. Maximum phosphorylation was induced by dihexanoylglycerol, diC8, and didecanoylglycerol at concentrations from 5 to 20 microM and between 5 and 30 S after exposure of platelets to these diacylglycerols. Under conditions of maximal phosphorylation of the 40,000-dalton protein, these diacylglycerols did not induce phosphatidylinositol turnover, or platelet aggregation, or stimulate release of ATP or serotonin. A small degree of aggregation was evident with platelets isolated in the absence of prostacyclin, and release of serotonin was observed when 1 mM Ca2+ or submaximal concentrations of ionophore A23187 were included. These results are consistent with a model in which platelet activation requires the simultaneous formation of two intracellular signals, diacylglycerols and Ca2+. These diacylglycerols and diacylglycerol analogs provide useful tools to investigate the function of diacylglycerols as bioregulators in intact cells.
A Fully Monolithic 1.25ghz cmos Frequency Synthesizer (2005)

A fully monolithic frcqucncy synthesizer PLL circuit implcmented in a 0.45pm CMOS tcchnology is prcscntcd. ?’lie test cliip consumcs 27omw at 1.25GIIz from a 3.3V supply. 1 he rms jitter of the gcnerated clock is 1.4~s. No external componcnts are uscd except supply dccoupling capacitois.
Development of a New Light Stratified-Charge DISI Combustion System for a Family of Engines With Upfront CFD Coupling With Thermal and Optical Engine Experiments (2004)

&lt;div class="htmlview paragraph"&gt;A new Light Stratified-Charge Direct Injection (LSC DI) spark ignition combustion system concept was developed at Ford. One of the new features of the LSC DI concept is to use a ‘light’ stratified-charge operation window ranging from the idle operation to low speed and low load. A dual independent variable cam timing (DiVCT) mechanism is used to increase the internal dilution for emissions control and to improve engine thermal efficiency. The LSC DI concept allows a large relaxation in the requirement for the lean after-treatment system, but still enables significant fuel economy gains over the PFI base design, delivering high technology value to the customer. In addition, the reduced stratified-charge window permits a simple, shallow piston bowl design that not only benefits engine wide-open throttle performance, but also reduces design compromises due to compression ratio, DiVCT range and piston bowl shape constraints.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The design, analysis, and experimental testing efforts in developing the combustion system are reported in this paper. A combustion system development methodology was developed and adopted. The methodology features vehicle target cascading, upfront CFD-based design optimization and single-cylinder thermodynamic and optically accessible engine testing for design validation and verification. Application of the methodology allowed a significant reduction of hardware iterations, reducing development time and cost. The LSC DI combustion systems were developed for a family of Ford engines with displacement variants of 0.5, 0.42 and 0.38 liter per cylinder. The systems retained substantial design and component commonality between the DI and PFI variants and among the displacement variants. Significant gains in engine output and fuel economy were demonstrated over the baseline PFI design.&lt;/div&gt;
Anthracene heme cyclophanes. Steric effects in carbon monoxide, molecular oxygen, and RNC binding (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnthracene heme cyclophanes. Steric effects in carbon monoxide, molecular oxygen, and RNC bindingT. G. Traylor, Shinji Tsuchiya, Dwane Campbell, Michael Mitchell, Dennis Stynes, and Noboru KogaCite this: J. Am. Chem. Soc. 1985, 107, 3, 604–614Publication Date (Print):February 1, 1985Publication History Published online1 May 2002Published inissue 1 February 1985https://pubs.acs.org/doi/10.1021/ja00289a012https://doi.org/10.1021/ja00289a012research-articleACS PublicationsRequest reuse permissionsArticle Views271Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fractional cointegration between nominal interest rates and inflation: A re-examination of the Fisher relationship in the G7 countries (2003)

International audience
Diagnosability of discrete-event systems (1995)

Fault detection and isolation is a crucial and challenging task in the automatic control of large complex systems. We propose a discrete-event system (DES) approach to the problem of failure diagnosis. We introduce two related notions of diagnosability of DES's in the framework of formal languages and compare diagnosability with the related notions of observability and invertibility. We present a systematic procedure for detection and isolation of failure events using diagnosers and provide necessary and sufficient conditions for a language to be diagnosable. The diagnoser performs diagnostics using online observations of the system behavior; it is also used to state and verify off-line the necessary and sufficient conditions for diagnosability. These conditions are stated on the diagnoser or variations thereof. The approach to failure diagnosis presented in this paper is applicable to systems that fall naturally in the class of DES's; moreover, for the purpose of diagnosis, most continuous variable dynamic systems can be viewed as DES's at a higher level of abstraction.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Effect of Pioglitazone Compared with Metformin on Glycemic Control and Indicators of Insulin Sensitivity in Recently Diagnosed Patients with Type 2 Diabetes (2003)

Pioglitazone, a thiazolidinedione, improves glycemic control primarily by increasing peripheral insulin sensitivity in patients with type 2 diabetes, whereas metformin, a biguanide, exerts its effect primarily by decreasing hepatic glucose output. In the first head-to-head, double-blind clinical trial comparing these two oral antihyperglycemic medications (OAMs), we studied the effect of 32-wk monotherapy on glycemic control and insulin sensitivity in 205 patients with recently diagnosed type 2 diabetes who were naive to OAM therapy. Subjects were randomized to either 30 mg pioglitazone or 850 mg metformin daily with titrations upward to 45 mg (77% of pioglitazone patients) and 2550 mg (73% of metformin patients), as indicated, to achieve fasting plasma glucose levels of less than 7.0 mmol/liter (126 mg/dl). Pioglitazone was comparable to metformin in improving glycemic control as measured by hemoglobin A1C and fasting plasma glucose. At endpoint, pioglitazone was significantly more effective than metformin in improving indicators of insulin sensitivity, as determined by reduction of fasting serum insulin (P = 0.003) and by analysis of homeostasis model assessment for insulin sensitivity (HOMA-S; P = 0.002). Both OAM therapies were well tolerated. Therefore, pioglitazone and metformin are equally efficacious in regard to glycemic control, but they exert significantly different effects on insulin sensitivity due to differing mechanisms of action. The more pronounced improvement in indicators of insulin sensitivity by pioglitazone, as compared with metformin monotherapy in patients recently diagnosed with type 2 diabetes who are OAM-naive, may be of interest for further clinical evaluation.
Observations on Interference Screw Morphologies (2000)

Summary: Interference screws are frequently used for fixation of anterior cruciate ligament grafts. When revision surgery is necessary, it is important for the surgeon to recognize variations in interference screw morphology to reduce the potential difficulties in screw removal. The purpose of this observational study is to review the variety of metallic and nonmetallic absorbable interference screws commonly available and to provide a review of their characteristics, dimensions available, and the type and size of screwdriver that would be required in the event that removal is necessary. Key Words: ACL reconstruction—Interference screw fixation—Screw variation.