gebhart/patrepeval huggingface dataset:
Learning and Recognition of 3-D Objects from Brightness Images * (1993)

We address the problem of automatically learning object models for recognition and pose estimation. In contrast to the traditional approach, the recognition problem is formulated here as one of matching visual appearance rather than shape. The appearance of an object in a two-dimensional image depends on its shape, reflectance properties, pose in the scene, and the illumination conditions. While shape and reflectance are intrinsic properties and are constant for a rigid object, pose and illumination vary from scene to scene. We present a new compact representation of object appearance that is parametrized by pose and illumination. For each object of interest, a large set of images is obtained by automatically varying pose and illumination. This large image set is compressed to obtain a low-dimensional subspace, called the eigenspace, in which the object is represented as a hypersurface. Given an unknown input image, the recognition system projects the image onto the eigenspace. The object is recognized based on the hypersurface it lies on. The exact position of the projection on the hypersurface determines the object’s pose in the image.
Enabling location-based policies in a healthcare cloud computing environment (2014)

In a multi-stakeholder cloud computing environment, data access control is of essential importance. Nowadays, it is usually handled in and deployed by every single cloud service on its own which makes the configuration of fine-grained access privileges cumbersome and economically expensive. In this paper, we introduce a novel cloud ecosystem architecture featuring an overall lightweight data access control model. This model is enabling data access policies based on location information of service consumer devices. We apply our architecture in the sensitive healthcare domain, which itself comprises multiple parties with complex data access privileges. Here, we define high-level requirements driven from current data protection regulations and guidelines as well as practice requirements in this area, which we address in the design of our architecture. We implement and test the main components. The results demonstrate the feasibility of our architecture and the applicability of our approach even in the healthcare application domain.
Prognostic impact of VEGF, CD31, CD34, and CD105 expression and tumour vessel invasion after radical surgery for IB–IIA non-small cell lung cancer (2004)

High MVD by CD34 and tumour vessel invasion are more closely related to poor survival than the other neoangiogenetic factors in stage IB-IIA NSCLC. This may be because these factors are more closely related to the metastatic process.
The Ewing Family of Tumors -- A Subgroup of Small-Round-Cell Tumors Defined by Specific Chimeric Transcripts (1994)

A subgroup of small-round-cell tumors identified as belonging to the Ewing family of tumors can be defined according to a specific molecular genetic lesion that is detectable by a rapid, reliable, and efficient method. This approach can be applied to small specimens obtained by fine-needle biopsies.
Mesoporous carbon as a carrier for celecoxib: The improved inhibition effect on MDA-MB-231 cells migration and invasion (2014)

In the current study, mesoporous carbon (MC) with pore volume (1.53 cm3/g) and pore size (9.74 nm) was successfully prepared as a carrier for celecoxib (CEL). Celecoxib was loaded into the pore channels of MC using three different methods: solvent evaporation method, absorption method and physical mixing method. Solid-state characterization methods, such as SEM, TEM, BET, DSC and XRD were used to systematically investigate the process of the drug loading system. Dissolution tests were performed to examine the effects of MC on the release of CEL. Furthermore, the cytotoxicity, wound healing, migration and invasion experiments were carried out to measure the contribution of MC to the anti-tumor metastasis ability of celecoxib on MDA-MB-231 cells. The results showed that CEL could be kept in a non-crystalline state when they were incorporated into the MC using the solvent evaporation method or absorption method. The dissolution rate of CEL released from MCS (Mesoporous carbon – Celecoxib – Solvent evaporation method) and MCA (Mesoporous carbon – Celecoxib – Absorption evaporation method) was all significantly higher than that of pure CEL. The cumulative release for MCS within the 5 min was up to 51.86%. MCS enhanced the inhibitory effect of CEL on the migration and invasion of MDA-MB-231 cells.
Puberty: A Finishing School for Male Social Behavior (2003)

The classical view of steroid-dependent organization of brain and behavior holds that gonadal steroid hormones, acting during an early critical period of development, cause permanent structural changes in neural circuits that determine behavioral responses to hormones in adulthood. This classical view has been modified to incorporate evidence that organizational effects of steroids can occur outside of the established perinatal critical period and that multiple critical periods may exist during development. Experiments in this laboratory indicate that steroid-dependent organization of neural circuits underlying male social behaviors occurs during puberty. This work shows that adult-typical reproductive and flank marking behaviors cannot be activated by gonadal steroids in male Syrian hamsters prior to puberty, suggesting that developmentally timed processes during puberty render the nervous system responsive to activating effects of gonadal steroids in adulthood. Additional experiments demonstrate that the presence or absence of gonadal hormones during puberty is a major factor in the ability of steroids to activate reproductive and flank marking behavior in adult male hamsters and in androgen receptor expression within the neural circuit underlying these behaviors. Thus, gonadal hormones during puberty appear to exert long-lasting changes in neural circuits that are responsible for the programming of activational responses to steroids later in adulthood. A two-stage model for maturation of male social behaviors is proposed: a perinatal critical period for sexual differentiation of neural circuits, followed by the pubertal period, during which gonadal steroids further organize the circuits to enhance behavioral responsiveness to hormones in adulthood. Whether puberty is a critical period for the proposed second wave of steroid-dependent organization of behavioral circuits remains to be determined.
The use of yoked base-up and base-in prism for reducing eye strain at the computer. (1996)

Eye strain continues to be one of the chief complaints of people working at video display terminals. The increase in extorsion observed on elevation of gaze at near point may induce binocular disruption and strain. Binocular base-up and base-in prism might mitigate some of the visual complaints of computer users because they decrease the elevation and convergence required. A double blind study of 30 computer users indicates a significantly greater preference for a lens combining prism and plus power than for plus lenses having no prism.
Acquiring Structural Information on Virus Particles with Charge Detection Mass Spectrometry (2016)

Charge detection mass spectrometry (CDMS) is a single-molecule technique particularly well-suited to measuring the mass and charge distributions of heterogeneous, MDa-sized ions. In this work, CDMS has been used to analyze the assembly products of two coat protein variants of bacteriophage P22. The assembly products show broad mass distributions extending from 5 to 15 MDa for A285Y and 5 to 25 MDa for A285T coat protein variants. Because the charge of large ions generated by electrospray ionization depends on their size, the charge can be used to distinguish hollow shells from more compact structures. A285T was found to form T = 4 and T = 7 procapsids, and A285Y makes a small number of T = 3 and T = 4 procapsids. Owing to the decreased stability of the A285Y and A285T particles, chemical cross-linking was required to stabilize them for electrospray CDMS.Graphical Abstract.
Etoposide phosphate: what, why, where, and how? (1996)

The podophyllotoxin derivatives etoposide and teniposide are active in the treatment of a variety of malignant conditions. Both represent chemical modifications of podophyllin, an extract of Podophyllum peltatum (May apple, mandrake, Indian apple, wild lemon, or duck's foot), a plant long used as a folk remedy and recognized in the 19th century to be effective in the treatment of cancer. While etoposide is active in the treatment of many cancers and is widely used, it has a number of limitations due to its lack of water solubility. Etoposide phosphate (Etopophos; Bristol-Myers Squibb Company, Princeton, NJ) is a water-soluble prodrug of etoposide that is rapidly and completely converted to the parent compound after intravenous dosing. The pharmacokinetic profile of etoposide after treatment with either etoposide or etoposide phosphate is identical. Toxicity and clinical activity also are the same. Because etoposide phosphate is water soluble and can be made up to a concentration of 20 mg/mL, however, it can be given as a 5-minute bolus, in high doses in small volumes, and as a continuous infusion. Furthermore, it is not formulated with polyethylene glycol, polysorbate 80 (Tween; ICI Americas, Wilmington, DE), and ethanol, and does not cause acidosis when given at high doses. The easier-to-use etoposide phosphate represents an improved formulation of etoposide.
Are animal models useful for understanding the pathophysiology of lysosomal storage disease? (2003)

Spontaneously occurring genetic lysosomal storage diseases are as rare in other mammalian species as in man. However, the advent of gene targeting technology has revolutionized the state of animal models of genetic diseases. Nearly all lysosomal storage diseases known in man have been duplicated in the mouse. The technology now allows, not only complete inactivation of endogenous genes, but also the introduction of essentially any type of mutation. These animal models can overcome many of the limitations inherent in studies of human patients - rarity of the disease, extremely complex genetic background and logistical and ethical constraints in the design and execution of experiments with human subjects. For example, genetic manipulations of germ cells or cross-breeding experiments between two mutants are readily feasible with animal models. Two major areas of the utility of animal models are the clarification of the pathophysiology/pathogenetic mechanism of disease and the exploration of therapeutic approaches. Examples of experiments using animal models of lysosomal storage disease are presented, primarily from studies undertaken in our own laboratory. Conclusion: Animal models have proved invaluable in extending our knowledge of the lysosomal storage diseases and exploring potential therapies.
Larotaxel with Cisplatin in the First-Line Treatment of Locally Advanced/Metastatic Urothelial Tract or Bladder Cancer: A Randomized, Active-Controlled, Phase III Trial (CILAB) (2013)

There was no difference in OS. Although the trial was closed prematurely, PFS appeared worse with larotaxel/cisplatin, suggesting that larotaxel/cisplatin does not improve outcomes versus cisplatin/gemcitabine.
High-performance 19 GHz-band GaAs FET switches using LOXI (Layered-Oxide-Isolation)-MESFETs (2002)

19 GHz-band GaAs MESFET switch ICs have been demonstrated, intended for use in high-speed wireless LAN systems. The FET channel is fabricated on a SiO/sub 2/ insulator in order to reduce parasitic FET drain-source capacitance (Cds) which acts as off-state capacitance (Coff) in switches. The LOXI (Layered-Oxide-Isolation)-MESFET has enough DC and RF performance for use as an active device. On-state FET resistance (Ron) remains the same as that of conventional MESFETs white Coff is reduced. This allows the use of larger gate-width switch FETs, which yield low insertion loss. The measured simple SPST (single-pole, single-throw) switch has low insertion loss of 0.5 dB and high isolation of 23 dB at 19 GHz. The measured simple SPDT (single-pole, double throw) switch also has good characteristics, 0.8 dB insertion loss and 17 dB isolation at 19 GHz.
Enhanced multi-threshold (MTCMOS) circuits using variable well bias (2002)

Advanced CMOS technology can enable high levels of performance with reduced active power at the expense of increased standby leakage, MTCMOS has previously been described as a method of reducing leakage in standby modes, by addition of a power supply interrupt switch. Enhancements using variable well bias and layout techniques are described and demonstrate increased performance and reduced leakage over conventional MTCMOS circuits.
Orientational order in polyethylene foils: A polarized Raman spectroscopic study (1993)

Abstract Polarized Raman spectroscopy was used to determine the order parameters of the orientational distribution function for a series of stretched polyethylene foils with a relatively low degree of molecular orientational order. By combining measurements of the foil under stduy and of an isotropic polyethylene foil, simple backscattering experiments are sufficient to determine the orientation order parameters of the foil with molecular orientation. Practical considerations for obtaining polarized Raman spectra are discussed. The results are in good agreement with the order parameters obtained by IR dichroism and wide‐angle x‐ray diffraction. Differences between the various methods are discussed. The Raman method proves to be a relatively rapid method for obtaining information concerning the molecular orientation in polyethylene films.
The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells (1993)

Mast cells release the mediators of the immediate hypersensitivity reaction. Adenosine is known to modulate this process, but the receptor responsible for this is not the classical A1 or A2 adenosine receptors. This study was undertaken to determine whether the unique adenosine receptor (AR) previously postulated in a cultured mast cell line (RBL-2H3 cells) is the recently cloned A3AR. The receptors were quantitated by the agonist 125I-labeled APNEA (aminophenylethyladenosine), an A3AR agonist, which yielded Bmax and Kd values of 826 fmol/mg protein and 34 nM, respectively. A variety of adenosine analogs competed for 125I-APNEA binding sites with the following potency series: (R)-phenylisopropyladenosine = 5'-N-ethylcarboxamide adenosine > (S)-phenylisopropyladenosine. 125I-APNEA binding was relatively insensitive to the xanthine amine congener (XAC, 1 microM), a selective antagonist for the A1AR. Functionally, activation of these A3AR stimulated the production of inositol 1,4,5-triphosphate, leading to an increase in the level of intracellular Ca2+. Furthermore, while activation of these receptors alone produced little secretory response in RBL-2H3 cells, it enhanced antigen-induced secretion by 2-2.5-fold. Northern blotting studies using poly(A+) RNA from RBL-2H3 cells detected two transcripts of 2.0 and 3.5 kilobases, which hybridized to an A3AR cDNA but not to the A1 or A2AR cDNA probes. These data indicate that the unique AR that potentiates the secretory response to antigen in RBL-2H3 cells is exclusively the A3AR.
Routine DNA Sequencing of 1000 Bases in Less Than One Hour by Capillary Electrophoresis with Replaceable Linear Polyacrylamide Solutions (1998)

Long, accurate reads are an important factor for high-throughput de novo DNA sequencing. In previous work from this laboratory, a separation matrix of high-weight-average molecular mass (HMM) linear polyacrylamide (LPA) at a concentration of 2% (w/w) was used to separate 1000 bases of DNA sequence in 80 min with an accuracy close to 97% (Carrilho, E.; et al. Anal. Chem. 1996, 68, 3305-3313). In the present work, significantly improved speed and sequencing accuracy have been achieved by further optimization of factors affecting electrophoretic separation and data processing. A replaceable matrix containing a mixture of 2.0% (w/w) HMM (9 MDa) and 0.5% (w/w) low-weight-average molecular mass (50 kDa) LPA was employed to enhance the separation of DNA sequencing fragments in CE. Experimental conditions, such as electric field strength and column temperature, as well as internal diameter of the capillary column, have been optimized for this mixed separation matrix. Under these conditions, in combination with energy-transfer (BigDye) dye-labeled primers for high signal-to-noise ratio and a newly developed expert system for base calling, the electrophoretic separation of 1000 DNA sequencing fragments of both standard (M13mp18) and cloned single-stranded templates from human chromosome 17 could be routinely achieved in less than 55 min, with a base-calling accuracy between 98 and 99%. Identical read length, accuracy, and migration time were achieved in more than 300 consecutive runs in a single column.
Two-dimensional single-cell patterning with one cell per well driven by surface acoustic waves (2015)

In single-cell analysis, cellular activity and parameters are assayed on an individual, rather than population-average basis. Essential to observing the activity of these cells over time is the ability to trap, pattern and retain them, for which previous single-cell-patterning work has principally made use of mechanical methods. While successful as a long-term cell-patterning strategy, these devices remain essentially single use. Here we introduce a new method for the patterning of multiple spatially separated single particles and cells using high-frequency acoustic fields with one cell per acoustic well. We characterize and demonstrate patterning for both a range of particle sizes and the capture and patterning of cells, including human lymphocytes and red blood cells infected by the malarial parasite Plasmodium falciparum. This ability is made possible by a hitherto unexplored regime where the acoustic wavelength is on the same order as the cell dimensions.
Amplification of electrical signals with molecule-based transistors: power amplification up to a kilohertz frequency and factors limiting higher frequency operation (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAmplification of electrical signals with molecule-based transistors: power amplification up to a kilohertz frequency and factors limiting higher frequency operationElizabeth Paul Lofton, James W. Thackeray, and Mark S. WrightonCite this: J. Phys. Chem. 1986, 90, 23, 6080–6083Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://pubs.acs.org/doi/10.1021/j100281a007https://doi.org/10.1021/j100281a007research-articleACS PublicationsRequest reuse permissionsArticle Views86Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia (2001)

This study characterizes an animal model of persistent mechanical hyperalgesia induced by repeated intramuscular injections of low pH saline. Saline at pH 4, 5, 6, or 7.2 was injected twice, 2 to 10 days apart, into the gastrocnemius muscle of rats. To quantify hyperalgesia, paw withdrawal latency to radiant heat (heat hyperalgesia) and withdrawal threshold to mechanical stimuli (mechanical hyperalgesia) were measured. Two unilateral injections of low pH saline, 5 days apart, caused a pH-dependent bilateral mechanical, but not heat, hyperalgesia that lasted 30 days. Injections given 2 and 5 days apart produced a significantly greater mechanical hyperalgesia than injections given 10 days apart. Lidocaine injection into the gastrocnemius muscle or unilateral dorsal rhizotomy, 24 h after the second injection (pH 4), had no effect on the contralateral mechanical hyperalgesia. Minimal histopathology was observed in the injected muscle, and changes were similar between groups injected with pH 4 and pH 7.2. Thus, this new model of widespread, chronic muscle-induced pain is unrelated to tissue damage and is not maintained by continued primary afferent input from the site of injury.
Endogenous and exogenous vasopressin in shock (2007)

Vasopressin administration is very effective in restoring arterial pressure in many forms of shock and this appears to be due, at least in part, to deficiency of endogenous hormone. Generation of mice lacking vasopressin V1a receptor open new and exciting avenues of inquiry to clarify the role of the hormone in cardiovascular homeostasis.
Effects of doxycycline on progression of osteoarthritis: Results of a randomized, placebo‐controlled, double‐blind trial (2005)

Doxycycline slowed the rate of JSN in knees with established OA. Its lack of effect on JSN in the contralateral knee suggests that pathogenetic mechanisms in that joint were different from those in the index knee.
Microvoltammetric techniques and sensors for monitoring neurochemical dynamics in vivo. A review (1994)

The first page of this article is displayed as the abstract.
HMAC-MD5 IP Authentication with Replay Prevention (1997)

This document describes a keyed-MD5 transform to be used in conjunction with the IP Authentication Header [RFC-1826]. The particular transform is based on [HMAC-MD5]. An option is also specified to guard against replay attacks.
The body as a communication medium (2009)

Body sensor networks are currently not very intuitive and not very reliable. In the last couple of years body coupled communications has been rediscovered after a period of disinterest. In this paper an overview of recent research into body coupled communications is given. This research into body coupled communications shows that body sensor networks are not the only ubiquitous computing application where it could be useful. From recent research a number of guidelines for using body coupled communications are developed to help future research in ubiquitous computing.