gebhart/patrepeval huggingface dataset:
The Geometric Mechanics of Undulatory Robotic Locomotion (1998)

This paper uses geometric methods to study basic problems in the mechanics and control of locomotion. We consider in detail the case of "undulatory locomotion" in which net motion is generated by coupling internal shape changes with external nonholonomic con straints. Such locomotion problems have a natural geometric inter pretation as a connection on a principal fiber bundle. The properties of connections lead to simplified results for studying both dynamics and issues of controllability for locomotion systems. We demonstrate the utility of this approach using a novel "snakeboard" and a mul tisegmented serpentine robot that is modeled after Hirose's active cord mechanism.
The CHINDIA-Connection and its implications for the Transatlantic Partnership (2006)

"With the emergence of China and India the focus of international politics is shifting more and more to Asia. American and European experts therefore discussed in a two-day conference at the Center for Applied Policy Research (C·A·P) the 'Chindia Connection' and the implications for the transatlantic partnership. The 14th Transatlantic Roundtable of the Improving Responsiveness Program, dealing with this important topic, was organized in cooperation with the U.S.Consulate General in Munich. The 25 Participants analysed various security and economy related aspects concerning the current approach of the United States and the European Union towards China and India and the increasing cooperation between both emerging powers. The Center for Applied Policy Research would like to thank the German Marshall Fund of the United States for enabling this conference by the generous support of the Transatlantic Roundtable Program as part of a Key Institution Grant to the C·A·P." (author's abstract)
Effect of ultrasonic treatment on dispersibility of Fe3O4 nanoparticles and synthesis of multi-core Fe3O4/SiO2 core/shell nanoparticles (2005)

Ultrasonic treatment was employed to improve the dispersibility of the Fe3O4 nanoparticles dispersed in aqueous solutions. Electrophoresis and XPS spectra indicate that the ultrasonic treatment can induce the generation of chemisorbed hydroxyl groups and the oxidation of Fe2+ ions on the surface of the magnetic nanoparticles, thus resulting in improved dispersibility of the magnetic nanoparticles. After growth of silica protection layers on the Fe3O4 nanoparticles with different times of ultrasonic treatment, Fe3O4/SiO2 core/shell nanoparticles with different amounts of the magnetic cores were successfully prepared.
Structure–activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds (2005)

Structure-activity relationship studies on CXCR4 antagonists, which were previously found by using cyclic pentapeptide libraries, were performed to optimize side-chain functional groups, involving conformationally constrained analogues. In addition, a new lead of cyclic pentapeptides with the introduction of a novel pharmacophore was developed.
The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline (2019)

Tissue nicotinamide adenine dinucleotide (NAD<sup>+</sup>) decline has been implicated in aging. We have recently identified CD38 as a central regulator involved in tissue NAD<sup>+</sup> decline during the aging process. CD38 is an ecto-enzyme highly expressed in endothelial and inflammatory cells. To date, the mechanisms that regulate CD38 expression in aging tissues characterized by the presence of senescent cells is not completely understood. Cellular senescence has been described as a hallmark of the aging process and these cells are known to secrete several factors including cytokines and chemokines through their senescent associated secretory phenotype (SASP). Here we investigated if the cellular senescence phenotype is involved in the regulation of CD38 expression and its NADase activity. We observed that senescent cells do not have high expression of CD38. However, the SASP factors secreted by senescent cells induced CD38 mRNA and protein expression and increased CD38-NADase activity in non-senescent cells such as endothelial cells or bone marrow derived macrophages. Our data suggest a link between cellular senescence and NAD<sup>+</sup> decline in which SASP-mediated upregulation of CD38 can disrupt cellular NAD<sup>+</sup> homeostasis.
Quantitative evaluation of the octadecylamine-assisted bulk separation of semiconducting and metallic single-wall carbon nanotubes by resonance Raman spectroscopy (2004)

The selective stabilization of octadecylamine (ODA) on semiconducting (S) single-wall carbon nanotubes (SWNTs) has been reported to provide a means for the bulk separation of S from metallic (M) SWNTs. Utilizing resonance Raman spectroscopy and, in particular, the relative changes in the integrated intensities of the radial-breathing mode region, a generic method has been developed to provide quantitative evaluation of the separation efficiency between M and S SWNTs along with diameter separation. The ODA-assisted separation is shown to provide S enrichment by a factor of 5 for SWNTs prepared by high pressure CO decomposition and greater S enrichment for SWNTs with diameters below 1nm.
A Phase I Trial and Pharmacokinetic Study of Aflibercept (VEGF Trap) in Children with Refractory Solid Tumors: A Children's Oncology Group Phase I Consortium Report (2012)

The aflibercept MTD in children of 2.5 mg/kg/dose every 14 days is lower than the adult recommended dose of 4.0 mg/kg. This dose achieves, but does not sustain, free aflibercept concentrations in excess of bound. Tumor pain and hemorrhage may be evidence of antitumor activity but were dose-limiting.
Overview of the genes of watermelon. (2008)

Watermelon (Citrullus lanatus (Thunb.) Matsum. &amp; Nakai) has 59\nmorphological and resistance gene mutants. The genes control traits that can be\ngrouped into seed and seedling traits, vine traits, flower traits, fruit traits, and\nresistance traits. This article includes a review of traits that result from these genes\nand their interaction, as well as future research needed.
Novel design principles enable specific targeting of imaging and therapeutic agents to necrotic domains in breast tumors (2010)

Non-covalent association to SA and covalent binding to c(RGDfK), synergistically enable the accumulation and prolonged retention of Bchl-Ds in the necrotic regions of tumors. These findings provide novel guidelines and strategy for imaging and treatment of necrotic tumors.
High throughput solution-based measurement of antibody-antigen affinity and epitope binning (2013)

Advances in human antibody discovery have allowed for the selection of hundreds of high affinity antibodies against many therapeutically relevant targets. This has necessitated the development of reproducible, high throughput analytical techniques to characterize the output from these selections. Among these characterizations, epitopic coverage and affinity are among the most critical properties for lead identification. Biolayer interferometry (BLI) is an attractive technique for epitope binning due to its speed and low antigen consumption. While surface-based methods such as BLI and surface plasmon resonance (SPR) are commonly used for affinity determinations, sensor chemistry and surface related artifacts can limit the accuracy of high affinity measurements. When comparing BLI and solution equilibrium based kinetic exclusion assays, significant differences in measured affinity (10-fold and above) were observed. KinExA direct association (k(a)) rate constant measurements suggest that this is mainly caused by inaccurate k(a) measurements associated with BLI related surface phenomena. Based on the kinetic exclusion assay principle used for KinExA, we developed a high throughput 96-well plate format assay, using a Meso Scale Discovery (MSD) instrument, to measure solution equilibrium affinity. This improved method combines the accuracy of solution-based methods with the throughput formerly only achievable with surface-based methods.
Composition, Secondary Structure, and Self-Assembly of Oat Protein Isolate (2009)

The amino acid compositions, secondary structure, and self-assembly of oat protein isolate (OPI), which was purified from the high-protein Chinese oat, have been investigated by using a combination of amino acid analysis, Fourier transform infrared spectroscopy (FTIR), and tapping mode atomic force microscopy (TP-AFM). OPI, with molecular weights ranging from 14.0 kDa to 66.0 kDa, was rich in essential amino acids and contained 24.7% glutamic acid and 8.1% leucine. The amino acid contents of OPI are 4.5-8.7 times higher than those of oat flour. The secondary structures of OPI have been quantified by the deconvolution of the amide I band of the FTIR spectrum of OPI, which were found to contain approximately 7% beta-turn, 19% alpha-helix, and 74% beta-sheet. Tapping mode AFM results further suggest that the oat protein isolate has two major types of shapes, ellipsoidal and disk-like. At protein concentrations below 0.5 mg/mL, most of the OPI molecules are in the isolated form. However, when the concentration of OPI reaches 1.0 mg/mL, some of the OPI molecules self-assembled into large and heterogeneous protein aggregates.
Kystes synoviaux intraspinaux lombaires: imagerie et traitement par infiltration. (2000)

Lumbar intraspinal synovial cysts: imaging and treatment by percutaneous injection. Report of thirteen cases Purpose. The CT and MR imaging findings in 13 patients with lumbar intra-spinal synovial cysts were retrospectively analysed and the results of facet corticosteroid injection were evaluated. Patients and methods. Over a 7 year period, 13 patients with radicular pain were identified as having lumbar intra-spinal synovial cysts. They ranged from 42 to 87 years of age. All patients were evaluated by CT without contrast material and underwent facet arthrography associated with corticosteroid injection and CT arthrography. MR imaging was performed in all patients either before or after percutaneous treatment. CT scans and MR images were reviewed and patient outcome was evaluated at 1-and 6-month follow-up. Results. CT scan revealed a cystic structure adjacent to a degenerated facet joint in 9 patients (69% sensitivity). MRI showed more accurately the cyst on T2 weighted and/or axial images. Complete or good relief of radicular pain and functional restrictions were achieved in 9 patients (69%) at 1 month follow-up, still to be found in 6 patients (46%) at 6 months. Conclusion. In patients with radiculopathy and facet degenerative changes, intra-spinal synovial cysts must be looked for. Facet corticosteroid injection is a useful alternative to surgical removal.
A Novel Androgen Receptor Splice Variant Is Up-regulated during Prostate Cancer Progression and Promotes Androgen Depletion–Resistant Growth (2009)

The androgen receptor (AR) plays a key role in progression to incurable androgen ablation-resistant prostate cancer (PCA). We have identified three novel AR splice variants lacking the ligand-binding domain (designated as AR3, AR4, and AR5) in hormone-insensitive PCA cells. AR3, one of the major splice variants expressed in human prostate tissues, is constitutively active, and its transcriptional activity is not regulated by androgens or antiandrogens. Immunohistochemistry analysis on tissue microarrays containing 429 human prostate tissue samples shows that AR3 is significantly up-regulated during PCA progression and AR3 expression level is correlated with the risk of tumor recurrence after radical prostatectomy. Overexpression of AR3 confers ablation-independent growth of PCA cells, whereas specific knockdown of AR3 expression (without altering AR level) in hormone-resistant PCA cells attenuates their growth under androgen-depleted conditions in both cell culture and xenograft models, suggesting an indispensable role of AR3 in ablation-independent growth of PCA cells. Furthermore, AR3 may play a distinct, yet essential, role in ablation-independent growth through the regulation of a unique set of genes, including AKT1, which are not regulated by the prototype AR. Our data suggest that aberrant expression of AR splice variants may be a novel mechanism underlying ablation independence during PCA progression, and AR3 may serve as a prognostic marker to predict patient outcome in response to hormonal therapy. Given that these novel AR splice variants are not inhibited by currently available antiandrogen drugs, development of new drugs targeting these AR isoforms may potentially be effective for treatment of ablation-resistant PCA.
Ipratropium bromide nasal spray in non‐allergic rhinitis: efficacy, nasal cytological response and patient evaluation on quality of life (1994)

Intranasal fluorocarbon anticholinergic agents have been used to treat the nasal hypersecretion of perennial non-allergic rhinitis, but chronic use has been restricted either due to the potential for systemic anticholinergic adverse events or due to the irritating properties of the fluorocarbon metered dose formulations. This study evaluates a new aqueous nasal formulation of ipratropium bromide (Atrovent Nasal Spray 0.03%) in subjects with perennial non-allergic rhinitis in a double-blind, placebo-controlled trial. Two hundred and twenty-eight patients were randomized to receive two sprays per nostril of either ipratropium bromide (42 micrograms/nostril) or placebo-administered three times a day as an aqueous nasal spray over an 8-week interval. Patients were evaluated bi-weekly and maintained daily diaries for duration and severity of nasal symptoms. Ipratropium bromide reduced the mean severity and duration of rhinorrhoea within the first week and throughout the 8 weeks of active treatment compared with placebo (P < 0.05). Secondary endpoints of efficacy (patient and physician global assessments and a quality of life assessment) also supported the use of ipratropium bromide nasal spray for rhinitis symptom control. With the reduction in rhinorrhoea by the ipratropium bromide nasal spray, patients reported a marked improvement in daily moods vs placebo (P < 0.01). Both placebo and ipratropium bromide nasal spray induced a modest reduction of nasal congestion, sneezing and postnasal drip. This improvement in these other nasal symptoms was consistent with the known soothing effects of a nasal saline vehicle. There were no drug-related serious or systemic anticholinergic adverse events.(ABSTRACT TRUNCATED AT 250 WORDS)
QUANTUM YIELDS OF THE LUMINOL CHEMILUMINESCENCE REACTION IN AQUEOUS AND APROTIC SOLVENTS* (1972)

Abstract— Quantum yields for luminol (3‐aminophthalic hydrazide) chemiluminescence reactions fall into two classes depending on oxidizing conditions. In aprotic solvents the quantum yield is high and the excitation yield which allows for the fluorescence quantum yield of the product, is 0·09 and is unaffected by changes in solution temperature or polarity, or the presence of quenchers. In aqueous solution under optimum pH conditions (11–13), hydrogen peroxide oxidation results in a high chemiluminescence quantum yield with an excitation yield of 0·04 again unaffected by temperature, viscosity or quenchers. Other oxidizing conditions produce lower quantum yields probably by the introduction of competing chemical pathways. The luminol chemiluminescence light standard has been used to calibrate a spectrofluoro‐meter with results in good agreement with the quantum yields of the ferrioxalate actinometer and the fluorescence of quinine sulfate and diphenylanthracene.
Studies on c-Kit and c-Met in Lung Cancer With Similarities to Stem Cells (2005)

Extract HTML view is not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button. Extended abstract of a paper presented at Microscopy and Microanalysis 2005 in Honolulu, Hawaii, USA, July 31--August 4, 2005
The relationship between MTHFR gene polymorphisms, plasma homocysteine levels and diabetic retinopathy in type 2 diabetes mellitus. (2003)

MTHFR gene C677T mutation associated with a predisposition to increased plasma homocysteine levels may be considered as a genetic risk factor for diabetic microangiopathy (such as DR) in Chinese patients with type 2 diabetes mellitus.
JAVA APPLICATION SERVER SECURITY USING CAPABILITIES (2000)

The Internet has fostered rapid growth in the use of application servers. Previously inaccessible outside private Intranets, application servers are increasingly appearing as the middle layer of three-tiered network applications. A GUI executing on a desktop establishes a session with an application server that implements product features on top of a third tier of legacy systems or databases. Supported by growing customer access to the Internet, the application server allows a business to rapidly deploy information products, and services. Java catalyzes the process by speeding the development of both the GUI and server software as well as making the GUI platform-independent.
Understanding how interactive television set-top box works. . .and what it will mean to the customer (1995)

A hybrid analog and digital basic set-top converter box that includes near video-on-demand and program guide service is currently being developed and deployed by cable TV operators. However, a more complex set-top will be required that will include a wide-range of interactive services and high-end graphic capabilities. Both the basic and the interactive set-top box are very cost sensitive applications with aggressive price targets. In a digital set-top, the cost of the semiconductor content represents a larger portion of the bill of materials. In order toparticipate in this market, semiconductor manufacturers are driven to develop ICs with a high level of functional integration. The requirements to achieve this integration include a complete portfolio of the intellectual property necessary to engage in this market: demodulation, error correction, transport stream demultiplexing, MPEG and AC3 audio, and MPEG2 and Digicipher II video, and a process technology that enables a cost-effective high level of integration. >
Serum Immunoglobulin Profiles of Dairy Cows Chronically Treated with Recombinant Bovine Somatotropin (1991)

The objective of this study was to determine the effects of exogenous somatotropin on blood profiles of the major bovine Ig isotypes. Holsteins were treated with either 0, 10.3, or 20.6 mg recombinant bST/d. Subcutaneous injections were started between wk 4 and 5 of lactation and continued for 266 d. Blood samples were collected by coccygeal venipuncture throughout lactation for serum IgG, G1, G2, A, and M concentration determination. Cows treated with 10.3 mg of bST/d exhibited modest increases in mean blood concentrations of IgG (12.4%) and IgG2 (18.4%) relative to the other groups of cows. In addition, treated cows had 10.1% higher average concentration of IgA than controls. Somatotropin did not influence average lactational concentrations of IgG1 or IgM, although the group receiving 10.3 mg/d had higher late lactation concentrations of IgG1 than did the other two groups. However, treatment mean isotype concentrations were always within normal ranges, except for IgG2 from the 10.3 mg/d group, which were higher. The practical significance of elevated serum Ig concentrations observed in the present study is not known. However, the present data do show that bST administered at doses that increased milk yield had no apparent detrimental effect on humoral immunity as measured by blood concentrations of Ig.
A Bi-Directional Message Passing Model for Salient Object Detection (2018)

Recent progress on salient object detection is beneficial from Fully Convolutional Neural Network (FCN). The saliency cues contained in multi-level convolutional features are complementary for detecting salient objects. How to integrate multi-level features becomes an open problem in saliency detection. In this paper, we propose a novel bi-directional message passing model to integrate multi-level features for salient object detection. At first, we adopt a Multi-scale Context-aware Feature Extraction Module (MCFEM) for multi-level feature maps to capture rich context information. Then a bi-directional structure is designed to pass messages between multi-level features, and a gate function is exploited to control the message passing rate. We use the features after message passing, which simultaneously encode semantic information and spatial details, to predict saliency maps. Finally, the predicted results are efficiently combined to generate the final saliency map. Quantitative and qualitative experiments on five benchmark datasets demonstrate that our proposed model performs favorably against the state-of-the-art methods under different evaluation metrics.
Platelet Activation Determines Angiopoietin-1 and VEGF Levels in Malaria: Implications for Their Use as Biomarkers (2013)

In contrast to previous studies, we found elevated plasma levels of Ang-1 and VEGF in patients with malaria resulting from in vivo platelet activation. Ang-1 release from platelets may be important to dampen the disturbing effects of Ang-2 on the endothelium. Evaluation of plasma levels of these angiogenic proteins requires close adherence to a stringent protocol to minimize ex vivo platelet activation.
Human Immunodeficiency Virus Type 1 Incorporated with Fusion Proteins Consisting of Integrase and the Designed Polydactyl Zinc Finger Protein E2C Can Bias Integration of Viral DNA into a Predetermined Chromosomal Region in Human Cells (2006)

In vitro studies using fusion proteins consisting of human immunodeficiency virus type 1 integrase (IN) and a synthetic polydactyl zinc finger protein E2C, a sequence-specific DNA-binding protein, showed that integration of retroviral DNA can be biased towards a contiguous 18-bp E2C-recognition site. To determine whether the fusion protein strategy can achieve site-specific integration in vivo, viruses were prepared by cotransfection and various IN-E2C fusion proteins were packaged in trans into virions. The resulting viruses incorporated with the IN-E2C fusion proteins were functional and capable of performing integration at a level ranging from 1 to 24% of that of viruses containing wild-type (WT) IN. Two of the more infectious viruses, which contained E2C fused to either the N (E2C/IN) or to the C (IN/E2C) terminus of IN, were tested for their ability to direct integration into a unique E2C-binding site present within the 5' untranslated region of erbB-2 gene on human chromosome 17. The copy number of proviral DNA was measured using a quantitative real-time nested-PCR assay, and the specificity of directed integration was determined by comparing the number of proviruses within the vicinity of the E2C-binding site to that in the whole genome. Viruses containing IN/E2C fusion proteins had sevenfold higher preference for integrating near the E2C-binding site than those viruses containing WT IN, whereas viruses containing E2C/IN had 10-fold higher preference. The results indicated that the IN-E2C fusion protein strategy is capable of directing integration of retroviral DNA into a predetermined chromosomal region in the human genome.
Probing the Probes (2002)

Ethnographic studies of technology have focused on trying to understand the socially organised, naturally occurring uses of technological artifacts in socio-technical systems. This paper describes the design work of two separate research groups utilising as a mode of participatory design for domestic settings. The first group created specially designed probes to analyse the motivations that shape life, to inspire future designs. The second group used a cultural probe derivative as an adjunct to an ethnographic study of a home setting - a sheltered housing complex - and used them for information rather than inspiration. The paper outlines an innovative evaluation of the production, use and methods that inform the use of probes for a participatory design and explore the ways in which cultural probes and probes hybrids might present alternative strategies for exploring sensitive settings.