gebhart/patrepeval huggingface dataset:
Cache Management Method for Query Forwarding Optimization in the Grid Database (2007)

A cache is used for optimization of query forwarding in the Grid database. To decrease network transmission cost, frequently used data is cached from meta database. Existing cache management method has a unbalanced resource problem, because it doesn't manage replicated data in each node. Also, it increases network cost by cache misses. In the case of data modification, if cache is not updated, queries can be transferred to wrong nodes and it can be occurred others nodes which have same cache. Therefore, it is necessary to solve the problems of existing method that are using unbalanced resource of replica and increasing network cost by cache misses. In this paper, cache management method for query forwarding optimization is proposed. The proposed method manages caches through cache manager. To optimize query forwarding, the cache manager makes caching data from lower loaded replicated node. The query processing cost and the network cost will decrease for the reducing of wrong query forwarding. The performance evaluation shows that proposed method performs better than the existing method.
Defensive secretion: biosynthesis of hydrogen cyanide and benzaldehyde from phenylalanine by a millipede (1972)

The polydesmid millipede, Oxidus gracilis, is able to convert dietary phenylalanine into benzaldehyde and hydrogen cyanide, components of its defensive secretion. This was shown in tracer experiments employing specifically labeled 14 C-phenylalanine. It is presumed that mandelonitrile is a precursor of HCN and benzaldehyde as has been demonstrated in plants.
Optics of Zero Dimensional Semiconductor Systems (1991)

The optical spectra of semiconductor microcrystals grown in transparent matrix of oxide glass are investigated. The size of microcrystals was varied in a controlled manner from a few tens to a few hundreds of angstroms. The microcrystal embedded in wide gap matrix represents three-dimensional potential well for electrons, holes and excitons. The optical properties of such zero-dimensional semiconductor structures are shown to be governed by the structure of energy spectra of confined electron-hole pairs. The phenomenon of the microcrystals ionization at interband optical excitation is observed. The Auger process in microcrystals containing two nonequilibrium electron-hole pairs is proposed to be responsible for this effect. The experimental dependencies of the ionization rate as a function of excitation intensity and the microcrystal size are in a good agreement with the theoretical predictions of the Auger recombiantion model.
A chelate‐controlled route to disubstituted and tetrasubstituted γ‐lactones stereoselectivity in lewis acid promoted additions to chiral methyl β‐formylcarboxylates (1989)

Abstract On reaction with allyltrimethylsilane/TiCl 4 , chiral methyl β‐for‐mylcarboxylates 1a – 1h provide disubstituted and tetrasubstituted γ‐lactones 3a – 3h with moderate to excellent diastereoselectivities. Other Lewis acids are less selective. The formation of seven‐membered ring chelates 1 · TiCl 4 has been proven unambiguously by NMR spectroscopy in several cases. Trichloromethyltitanium displays a selectivity pattern similar to the reagen combination allylsilane/TiCl 4 . Aldehydes 1a – 1d , 1g , and 1h give primarily trans ‐γ‐lactones, whereas under appropriate conditions 1f affords an excess of cis ‐γ‐lactone 3f . These results are discussed with regard to the Felkin‐Anh model and to chelate formation. Model studies with simpler chiral aldehydes 5 and 7 as well as with acetals 9a / b and 11a / b are presented and discussed. They emphasize the importance of chelate control in additions to β‐formyl esters 1 .
Expression of a Variant of CD28 on a Subpopulation of Human NK Cells: Implications for B7-Mediated Stimulation of NK Cells (1999)

The ability of NK cells to kill tumor cells is controlled by a balance between activating and inhibitory signals transduced by distinct receptors. In murine tumor models, the costimulatory molecule B7.1 not only acts as a positive trigger for NK-mediated cytotoxicity but can also overcome negative signaling transduced by MHC class I molecules. In this study, we have evaluated the potential of human B7.1-CD28 interaction as an activating trigger for human blood NK cells. Using multiparameter flow cytometric analysis and a panel of different CD28 mAbs, we show that human peripheral blood NK cells (defined by CD56+, CD16+, and CD3- surface expression) express the CD28 costimulatory receptor, with its detection totally dependent on the mAb used. In addition, the level of CD28 varies among individuals and on different NK cell lines, irrespective of CD28 steady-state mRNA levels. By performing Ab binding studies on T cells, our data strongly suggest that binding of two of the anti-CD28 Abs (clones 9.3 and CD28.2) is to a different epitope to that recognized by clones L293 and YTH913.12, which is perhaps modified in the CD28 molecule expressed by the NK cells. We also show that B7.1 enhances the NK-mediated lysis of NK-sensitive but not of NK-resistant tumor cells and that this increased lysis is dependent on CD28-B7 interactions as shown by the ability of Abs to block this lysis. Coculture of the B7.1-positive NK-sensitive cells also led to the activation of the NK cells, as determined by the expression of CD69, CD25, and HLA class II.
A Chemosterilized Antigen-Extracted Autodigested Alloimplant for Bone Banks (1975)

Limited chemical extraction of hydrophobic glycopeptides and subtotal autodigestion of the donor's cells and plasma membranes in undemineralized cortical bone in vitro reduces the putative quantity of haptenic substances absorbed by the recipient. Iodoacetic acid and sodium azide or other sulfhydryl group enzyme inhibitors added to the buffer solutions during in vitro autodigestion and estraction of intracellular alloantigens protects the bone matrix morphogenetic property against enzymatic degradation. The delayed hypersensitivity reaction induced by aseptically collected freeze-dried bone and the destruction of the bone morphogenetic property caused by radiation-sterilization is avoidable by sequential chemodigestion and chemosterilization of bone that preserves the maximum morphogenetic potential while transferring a minimum quantity of alloantigen.
The advanced glycation end product Nepsilon-(carboxymethyl)lysine is increased in serum from children and adolescents with type 1 diabetes. (1998)

Serum levels of CML are increased in patients with type 1 diabetes. This increase precedes the development of micro- and macrovascular complications.
Hyponatremia (2000)

Hyponatremia is defined as a decrease in the serum sodium concentration to a level below 136 mmol per liter. Whereas hypernatremia always denotes hypertonicity, hyponatremia can be associated with low, normal, or high tonicity.1,2 Effective osmolality or tonicity refers to the contribution to osmolality of solutes, such as sodium and glucose, that cannot move freely across cell membranes, thereby inducing transcellular shifts in water.3 Dilutional hyponatremia, by far the most common form of the disorder, is caused by water retention. If water intake exceeds the capacity of the kidneys to excrete water, dilution of body solutes results, causing hypo-osmolality . . .
Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras (2000)

Histone deacetylase 4 (HDAC4) is a member of a family of enzymes that catalyze the removal of acetyl groups from core histones, resulting in a compact chromatin structure that is generally associated with repressed gene transcription. Protein phosphorylation has been implicated in the regulation of the corepressor activity of the deacetylase. Here we report that serine/threonine kinases are found in association with HDAC4 and phosphorylate HDAC4 in vitro, and HDAC4 is phosphorylated in cells. The extracellular signal-regulated kinases 1 and 2 (ERK1/2), also known as p44(MAPK) and p42(MAPK), respectively, are two of the kinases associated with HDAC4. ERK1/2 are components of the Ras-mitogen-activated protein kinase (MAPK) signal transduction pathway. Activation of the Ras-MAPK pathway by expression of oncogenic Ras or constitutively active MAPK/ERK kinase 1 results in an increased percentage of cells (from approximately 10% to approximately 70%) that express HDAC4 in the nucleus in C2C12 myoblast cells. In cells transfected with oncogenic Ras, nuclear HDAC4 is associated with kinase activity. Our results provide evidence that protein kinase activity is present in a protein complex with HDAC4 and directly links the Ras-MAPK signal transduction pathway to a mechanism for chromatin remodeling (i.e., histone deacetylation).
Comparison of the efficacies of amphotericin B, fluconazole, and itraconazole against a systemic Candida albicans infection in normal and neutropenic mice (1989)

We compared the efficacies of the new triazole antifungal drugs fluconazole and itraconazole with that of amphotericin B in vitro and in an animal model of systemic candidiasis in normal and neutropenic mice. Antifungal treatment with fluconazole (2.5 to 20 mg/kg orally twice daily), itraconazole (10 to 40 mg/kg orally twice daily), or amphotericin B (0.1 to 4 mg/kg intraperitoneally once daily) was started 1 day after intravenous injection of 10(4) Candida albicans into normal mice or 10(3) C. albicans into neutropenic mice; the drugs were administered for 2 days. In normal mice the efficacy of treatment, which was assessed on the basis of the number of C. albicans cultured from the kidney, was greater for amphotericin B than for the triazoles. Fluconazole was more potent than itraconazole on the basis of equivalent doses, although itraconazole was more potent on the basis of the amount of free drug that was available. In neutropenic mice amphotericin B was less effective than it was in normal mice, whereas the triazoles were equally effective in normal and neutropenic mice. This was not expected, since in vitro data showed that amphotericin B was highly fungicidal, whereas both fluconazole and itraconazole had only a minimal effect on the growth of C. albicans in vitro.
Inducers of interferon and host resistance, IV. Double-stranded replicative form RNA (MS2-Ff-RNA) from E. coli infected with MS2 coliphage. (1967)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
A review of fracturing fluid systems used for hydraulic fracturing of oil and gas wells (2014)

ABSTRACT Hydraulic fracturing has been used by the oil and gas industry as a way to boost hydrocarbon production since 1947. Recent advances in fracturing technologies, such as multistage fracturing in horizontal wells, are responsible for the latest hydrocarbon production boom in the US. Linear or crosslinked guars are the most commonly used fluids in traditional fracturing operations. The main functions of these fluids are to open/propagate the fractures and transport proppants into the fractures. Proppants are usually applied to form a thin layer between fracture faces to prop the fractures open at the end of the fracturing process. Chemical breakers are used to break the polymers at the end of the fracturing process so as to provide highly conductive fractures. Concerns over fracture conductivity damage by viscous fluids in ultra‐tight formations found in unconventional reservoirs prompted the industry to develop an alternative fracturing fluid called “slickwater”. It consists mainly of water with a very low concentration of linear polymer. The low concentration polymer serves primarily to reduce the friction loss along the flow lines. Proppant‐carrying capability of this type of fluids is still a subject of debate among industry experts. Constraints on local water availability and the potential for damage to formations have led the industry to develop other types of fracturing fluids such as viscoelastic surfactants and energized fluids. This article reviews both the traditional viscous fluids used in conventional hydraulic fracturing operations as well as the new family of fluids being developed for both traditional and unconventional reservoirs. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40735.
Stabilizing unstable species through single-site isolation: a catalytically active TaV trialkyl in a porous organic polymer (2013)

A catechol-functionalized porous organic polymer (POP) has been successfully metallated with a TaV trialkyl and remains thermally and structurally robust. The resulting POP-supported (catecholato)TaV trialkyl sites remain accessible to small molecules and can undergo reactions to yield stable, monomeric complexes that are quite different from those observed with the homogeneous analogues. Using a combination of reactivity studies, high-resolution solid-state NMR spectroscopy, and X-ray absorption spectroscopy (XAS), we are able to precisely determine the functionality and coordination environment of the active (catecholato)TaV trialkyl site and its products in reactions with Brønsted acids. Additionally, the Ta-metallated POP was found to have enhanced catalytic activity in the hydrogenation of cyclohexene and toluene relative to a homogeneous analogue.
High temporal and spatial resolution 4D MRA using spiral data sampling and sliding window reconstruction (2004)

Contrast-enhanced magnetic resonance angiography (CE-MRA) requires high spatial resolution to demonstrate detailed vasculature and high temporal resolution to capture the contrast bolus. Sparse bright voxels in MRA permit substantial undersampling in MRI data acquisition, allowing simultaneous high temporal and spatial resolution. We developed a time-resolved 3D MRA technique using the efficient spiral sampling trajectory, and performed off-resonance corrections using inhomogeneity field maps. View sharing and sliding window reconstruction were utilized to generate high temporal resolution. High-resolution 3D angiograms were generated at 1-2 s per frame, with a 5-8 ml gadolinium dose, in patients with vascular disease.
[Model of aberrant DNA methylation patterns and its applications in epithelial ovarian cancer.]. (2009)

The aberrant DNA methylation pattern of epithelial ovarian cancer is important for finding new cancer related genes. The promoter CGI of gene LSM2, EGFLAM and CDKN2A may be novel candidate for ovarian cancer-specific hypomethylated tumor markers.
Occurrence of Taurine in Plants (1986)

(1986). Occurrence of Taurine in Plants. Agricultural and Biological Chemistry: Vol. 50, No. 7, pp. 1887-1888.
Schaum's outline of theory and problems of numerical analysis (1988)

What Is Numerical Analysis? The Collocation Polynomial. Finite Differences. Factorial Polynomials. Summation. The Newton Formula. Operators and Collocation Polynomials. Unequally-Spaced Arguments. Splines. Osculating Polynomials. The Taylor Polynomial. Interpolation. Numerical Differentiation. Numerical Integration. Gaussian Integration. Singular Integrals. Sums and Series. Difference Equations. Differential Equations. Differential Problems of Higher Order. Least-Squares Polynomial Approximation. Min-Max Polynomial Approximation. Approximation By Rational Functions. Trigonometric Approximation. Nonlinear Algebra. Linear Systems. Linear Programming. Overdetermined Systems. Boundary Value Problems. Monte Carlo Methods.
Inhibition of Cystine Uptake Disrupts the Growth of Primary Brain Tumors (2005)

Glial cells play an important role in sequestering neuronally released glutamate via Na+-dependent transporters. Surprisingly, these transporters are not operational in glial-derived tumors (gliomas). Instead, gliomas release glutamate, causing excitotoxic death of neurons in the vicinity of the tumor. We now show that glutamate release from glioma cells is an obligatory by-product of cellular cystine uptake via system xc-, an electroneutral cystine-glutamate exchanger. Cystine is an essential precursor for the biosynthesis of glutathione, a major redox regulatory molecule that protects cells from endogenously produced reactive oxygen species (ROS). Glioma cells, but not neurons or astrocytes, rely primarily on cystine uptake via system xc- for their glutathione synthesis. Inhibition of system xc- causes a rapid depletion of glutathione, and the resulting loss of ROS defense causes caspase-mediated apoptosis. Glioma cells can be rescued if glutathione status is experimentally restored or if glutathione is substituted by alternate cellular antioxidants, confirming that ROS are indeed mediators of cell death. We describe two potent drugs that permit pharmacological inhibition of system xc-. One of these drugs, sulfasalazine, is clinically used to treat inflammatory bowel disease and rheumatoid arthritis. Sulfasalazine was able to reduce glutathione levels in tumor tissue and slow tumor growth in vivo in a commonly used intracranial xenograft animal model for human gliomas when administered by intraperitoneal injection. These data suggest that inhibition of cystine uptake into glioma cells through the pharmacological inhibition of system xc- may be a viable therapeutic strategy with a Food and Drug Administration-approved drug already in hand.
Postprandial hypergastrinaemia in patients with colorectal cancer. (1991)

Gastrin is trophic to colon cancers that possess gastrin receptors. Whether fasting serum gastrin concentrations are high in patients with colon cancer is controversial. We therefore studied the effect of food on serum gastrin concentrations in patients with colon cancer and control subjects. Fasting serum gastrin was greater, though not significantly so, in patients with colon cancer before surgery (mean (SD) 17.4 (3.6) pmol/l, n = 16) compared with control subjects (12.6 (1.9) pmol/l, n = 14). Postprandial increases in serum gastrin were significantly and persistently higher than normal in the cancer patients. These increases were due to a subset of six patients with serum gastrin concentrations greater than the control mean + 2 SD at 20 and 40 minutes (62 pmol/l-146 pmol/l). Four of the six patients had intra-abdominal metastases. The extent of the increase may well correlate with that of the disease. Surgical resection of the tumour resulted in a fall in serum gastrin values and probably reflects the cause of the hypergastrinaemia. Hypergastrinaemia may, therefore, be an important aetiological factor in colon carcinogenesis.
Williams-Beuren syndrome:genes and mechanisms (1999)

Williams-Beuren syndrome (WBS; OMIM 194050) is caused by heterozygous deletions of approximately 1.6 Mb of chromosomal sub-band 7q11.23. The deletions are rather uniform in size as they arise spontaneously by inter- or intrachromosomal crossover events within misaligned duplicated regions of high sequence identity that flank the typical deletion. This review will discuss the status of the molecular characterization of the deletion and flanking regions, the genes identified in the deletion region and their possible roles in generating the complex multi-system clinical phenotype.
Detecting Supercritical CO2in Brine at Sequestration Pressure with an Optical Fiber Sensor (2012)

Monitoring of sequestered carbon is essential to establishing the environmental safety and the efficacy of geological carbon sequestration. Sequestration in saline aquifers requires the detection of supercritical CO(2) and CO(2)-saturated brine as distinct from the native reservoir brine. Here we demonstrate an all-optical approach to detect both supercritical CO(2), and saturated brine under sequestration conditions. The method employs a long-period grating written on an optical fiber with a resonance wavelength that is sensitive to local refractive index within a pressure- and temperature-controlled apparatus at 40 °C and 1400 psi (9.65 MPa). The supercritical CO(2) and brine are clearly distinguished by a wavelength shift of 1.149 nm (refractive index difference of 0.2371). The CO(2)-saturated brine is also detectable relative to brine, with a resonance wavelength shift of 0.192 nm (refractive index difference of 0.0396). Importantly, these findings indicate the potential for distributed, all-optical monitoring of CO(2) sequestration in saline aquifers.
Encapsulated, Genetically Engineered Cells, Secreting Glucagon‐like Peptide‐1 for the Treatment of Non‐insulin‐dependent Diabetes Mellitus (1999)

Non-insulin-dependent, or type II, diabetes mellitus is characterized by a progressive impairment of glucose-induced insulin secretion by pancreatic beta cells and by a relative decreased sensitivity of target tissues to the action of this hormone. About one third of type II diabetic patients are treated with oral hypoglycemic agents to stimulate insulin secretion. These drugs however risk inducing hypoglycemia and, over time, lose their efficacy. An alternative treatment is the use of glucagon-like peptide-1 (GLP-1), a gut peptidic hormone with a strong insulinotropic activity. Its activity depends of the presence of normal blood glucose concentrations and therefore does not risk inducing hypoglycemia. GLP-1 can correct hyperglycemia in diabetic patients, even in those no longer responding to hypoglycemic agents. Because it is a peptide, GLP-1 must be administered by injection; this may prevent its wide therapeutic use. Here we propose to use cell lines genetically engineered to secrete a mutant form of GLP-1 which has a longer half-life in vivo but which is as potent as the wild-type peptide. The genetically engineered cells are then encapsulated in semi-permeable hollow fibers for implantation in diabetic hosts for constant, long-term, in situ delivery of the peptide. This approach may be a novel therapy for type II diabetes.
Switching Amino-terminal Cytoplasmic Domains of α(1,2)Fucosyltransferase and α(1,3)Galactosyltransferase Alters the Expression of H Substance and Galα(1,3)Gal (1996)

When alpha(1,2)fucosyltransferase cDNA is expressed in cells that normally express large amounts of the terminal carbohydrate Galalpha(1,3)Gal, and therefore the alpha(1,3)galactosyltransferase (GT), the Galalpha(1,3)Gal almost disappears, indicating that the presence of the alpha(1,2)fucosyltransferase (HT) gene/enzyme alters the synthesis of Galalpha(1,3)Gal. A possible mechanism to account for these findings is enzyme location within the Golgi apparatus. We examined the effect of Golgi localization by exchanging the cytoplasmic tails of HT and GT; if Golgi targeting signals are contained within the cytoplasmic tail sequences of these enzymes then a "tail switch" would permit GT first access to the substrate and thereby reverse the observed dominance of HT. Two chimeric glycosyltransferase proteins were constructed and compared with the normal glycosyltransferases after transfection into COS cells. The chimeric enzymes showed Km values and cell surface carbohydrate expression comparable with normal glycosyltransferases. Co-expression of the two chimeric glycosyltransferases resulted in cell surface expression of Galalpha(1,3)Gal, and virtually no HT product was expressed. Thus the cytoplasmic tail of HT determines the temporal order of action, and therefore dominance, of these two enzymes.
Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways (2001)

PGs were initially discovered in human seminal fluid and originate from the seminal vesicles. Semen contains PGs derived from the three fatty acids, dihomogammalinoleic, arachidonic, and eicosapentaenoic acids. The two most abundant PGs are 19R-hydroxy-PGE 1 and 19R-hydroxy-1482