gebhart/patrepeval huggingface dataset:
Multi-frequency characterization of speed of sound for longitudinal transmission on freshly excised human skulls (2010)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Samuel Pichardo, Kullervo Hynynen; Multi‐frequency characterization of speed of sound for longitudinal transmission on freshly excised human skulls. AIP Conf. Proc. 9 March 2010; 1215 (1): 282–284. https://doi.org/10.1063/1.3367161 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
A Growth Factor Phenotype Map for Ovine Preimplantation Development1 (1994)

The reverse transcription-polymerase chain reaction (RT-PCR) was used to determine the patterns of expression for several growth factor ligand and receptor genes during ovine preimplantation development. Transcripts for insulin-like growth factor (IGF)-I, IGF-II, and the receptors for insulin and IGF-I were detected throughout ovine preimplantation development from the 1-cell to the blastocyst stage. Transforming growth factor alpha (TGF alpha) transcripts were also detected throughout ovine preimplantation development. The mRNAs encoding basic fibroblast growth factor (bFGF) were detected in all stages of the ovine preimplantation embryo, although the relative abundance of this transcript consistently decreased from the 1-cell to the blastocyst stage, suggesting that it may represent a maternal transcript in early sheep embryos. Transcripts encoding ovine trophoblast protein (oTP) were detected only within blastocyst-stage embryos. Primary ovine oviduct cell cultures express the transcripts for IGF-II, IGF-I, TGF alpha, bFGF, TGF beta 1, and the receptors for insulin and IGF-I, suggesting that paracrine growth factor circuits may exist between the oviduct epithelium and the early ovine embryo. Transcripts for insulin, epidermal growth factor (EGF), and nerve growth factor (NGF) were not detected in any stage of the ovine preimplantation embryo or within the oviduct cell preparations. The expression of growth factor transcripts very early in mammalian development would predict that these molecules fulfil a necessary role(s) in supporting the progression of early embryos through the preimplantation interval. Our future efforts will be directed to understanding the nature of these putative regulatory pathways.
Placement Control of Nanomaterial Arrays on Surface-Reconstructed Block Copolymer Thin Films (2009)

We present a control strategy for the facile placement of densely packed nanomaterial arrays (&lt;i&gt;i.e.&lt;/i&gt;, nanoparticles and nanorods) on surface reconstructed polystyrene-&lt;i&gt;block&lt;/i&gt;-poly(methyl methacrylate) thin film patterns. The surface reconstruction of perpendicularly oriented block copolymer thin films, which were produced by a treatment with selective solvent vapors for both blocks, created the topographical nanopatterns with enough height contrast for nanoparticle deposition without the need for additional selective etching of a single block domain. The deposition method of nanomaterials was also optimized, and densely packed one- and two-dimensional nanomaterials arrays in the grooves of the block copolymer film patterns were fabricated efficiently. Then, we demonstrated that height contrast of the surface reconstructed block copolymer films could be reversed by electron beam irradiation resulting in nanomaterial arrays placed at the mesa phase of the nanopatterns. On the basis of this nanomaterial placement control strategy, dual nanomaterial arrays on a single block copolymer pattern were also realized.
Membrane topology of the integral membrane components, OppB and OppC, of the oligopeptide permease of Salmonella typhimurium (1992)

The oligopeptide permease of Salmonella typhimurium is a periplasmic binding protein-dependent transport system. Five gene products, OppABCDF, are required for the functioning of this transporter, two of which (OppB and OppC) are highly hydrophobic, integral membrane proteins and are responsible for mediating passage of peptides across the cytoplasmic membrane. OppB and OppC are each predicted, from their sequences, to span the membrane many times. In this paper we describe experimental evidence confirming these predictions using a combination of biochemical, immunological and genetic procedures. Each of these two proteins is shown to span the membrane six times, with the N- and C-termini both being located at the cytoplasmic face of the membrane. Opp is apparently a typical member of the ABC (ATP-binding cassette) superfamily of transporters. These findings, therefore, have general implications for the organization and function of other ABC transporters, including the human multidrug resistance protein and the product of the cystic fibrosis gene.
A novel testis-specific gene, SPAG4, whose product interacts specifically with outer dense fiber protein ODF27, maps to human chromosome 20q11.2 (1998)

The product of the spermatid-specific rat SPAG4 gene interacts specifically with the major 27-kDa outer dense fiber protein ODF27 in elongating spermatids. In this study we isolated the human homolog of the spermatid-specific rat SPAG4 gene and mapped it by fluorescence in situ hybridization to chromosome 20q11.2.
Human T cells from autoimmune and normal individuals can produce tumor necrosis factor (1987)

T cell clones derived from patients with autoimmune diseases were found to be capable of producing tumor necrosis factor (TNF). This was demonstrated by stimulating the clones, in the absence of accessory cells, with antibodies against the Ti/T3 complex and with recombinant interleukin 2 (IL2). Analysis of RNA extracted from these clones showed that TNF mRNA was more abundant than lymphotoxin (LT) mRNA. We also found that TNF protein in the supernatants of these clones was generally more abundant than LT as assessed by using the murine L929 cell assay. TNF production was not limited to T cells from autoimmune individuals, since the T cell tumor HUT78 and T cells purified from the peripheral blood of healthy individuals also made TNF. Unlike the T cell clones, HUT78 produced greater amounts of LT mRNA than TNF mRNA. Induction of TNF mRNA in T cells from healthy individuals displayed a two-signal requirement (phorbol myristate 13-acetate and phytohemagglutinin or OKT3 and phorbol myristate 13-acetate), similar to that described for the induction of the T cell lymphokines IL 2 and interferon-gamma (IFN-gamma). Additionally we found that IL2 alone was sufficient to induce TNF in these cells when they had been precultured with phytohemagglutinin for 7 days to express IL 2 receptors. The cloned T cells we have characterized also produce IFN-gamma which was detected in the supernatants of the clones using a radioimmunoassay. The evidence suggests that T cells can produce TNF and have the potential to deliver by themselves the dual and synergistic signals of TNF/LT and IFN-gamma to target cells, a process which may be of importance in the pathogenesis of human autoimmunity.
Fate of Dispersants Associated with the Deepwater Horizon Oil Spill (2011)

Response actions to the Deepwater Horizon oil spill included the injection of ∼771,000 gallons (2,900,000 L) of chemical dispersant into the flow of oil near the seafloor. Prior to this incident, no deepwater applications of dispersant had been conducted, and thus no data exist on the environmental fate of dispersants in deepwater. We used ultrahigh resolution mass spectrometry and liquid chromatography with tandem mass spectrometry (LC/MS/MS) to identify and quantify one key ingredient of the dispersant, the anionic surfactant DOSS (dioctyl sodium sulfosuccinate), in the Gulf of Mexico deepwater during active flow and again after flow had ceased. Here we show that DOSS was sequestered in deepwater hydrocarbon plumes at 1000-1200 m water depth and did not intermingle with surface dispersant applications. Further, its concentration distribution was consistent with conservative transport and dilution at depth and it persisted up to 300 km from the well, 64 days after deepwater dispersant applications ceased. We conclude that DOSS was selectively associated with the oil and gas phases in the deepwater plume, yet underwent negligible, or slow, rates of biodegradation in the affected waters. These results provide important constraints on accurate modeling of the deepwater plume and critical geochemical contexts for future toxicological studies.
The Urological Application of Electrosurgery (1991)

No AccessJournal of UrologyReview Article1 Sep 1991The Urological Application of Electrosurgery Eugene V. Kramolowsky, and Robert D. Tucker Eugene V. KramolowskyEugene V. Kramolowsky , and Robert D. TuckerRobert D. Tucker View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)37890-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1991 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByHakim L, Kulaksizoglu H, Hamill B, Udelson D and Goldstein I (2018) A Guide to Safe Corporotomy Incisions in the Presence of Underlying Inflatable Penile Cylinders: Results of In Vitro and In Vivo StudiesJournal of Urology, VOL. 155, NO. 3, (918-923), Online publication date: 1-Mar-1996.Kaplan S and Te A (2018) A Comparative Study of Transurethral Resection of the Prostate Using a Modified Electro-Vaporizing Loop and Transurethral Laser Vaporization of the ProstateJournal of Urology, VOL. 154, NO. 5, (1785-1790), Online publication date: 1-Nov-1995.Secrest C, Jordan G, Winslow B, Horton C, McCraw J, Gilbert D and Devine C (2018) Repair of the Complications of Hypospadias SurgeryJournal of Urology, VOL. 150, NO. 5 Part 1, (1415-1418), Online publication date: 1-Nov-1993. Volume 146Issue 3September 1991Page: 669-674 Advertisement Copyright & Permissions© 1991 by The American Urological Association Education and Research, Inc.KeywordselectrocoagulationcauteryMetricsAuthor Information Eugene V. Kramolowsky More articles by this author Robert D. Tucker More articles by this author Expand All Advertisement PDF DownloadLoading ...
Monooxygenase enzyme activity in alcoholics with varying degrees of liver damage. (1979)

Monooxygenase enzymes are involved in the biotransformation of drugs and of environmental carcinogens. The activity of 7-ethoxycoumarin 0-deethylase and associated NADPH-cytochrome c reductase was determined in 9000 g supernatant from bioptically obtained liver specimens from patients with various liver diseases in order to study in vitro drug metabolising capacity. Monooxygenase and reductase activity was significantly higher in the livers of 21 patients with alcoholic liver disease (fatty liver, alcoholic hepatitis, cirrhosis of the liver) than in 22 normal controls or in six patients with chronic active hepatitis. The raised activity of drug-metabolising enzymes obtained from alcoholics with liver damage differs from normal values found in five alcoholics without liver disease. Both groups were comparable in respect to the amount of alcohol consumed and duration of abuse. A strikingly low monooxygenase activity was observed in eight patients with cirrhosis of the liver and ascites, with, however, no apparent effect on reductase activity. The results show that alcoholic liver disease is associated with enhanced monooxygenase and reductase activity, but alcoholism, per se, is not. This rise of drug-metabolising enzyme activity could lead to selectively increased rates of biotransformation in patients with alcoholic liver damage.
Four dierent tricks to bypass StackShield and StackGuard protection (2002)

Stack shielding technologies have been developed to protect programs against exploitation of stack based buer overflows . Among dierent types of protections, we can separate two mayor groups. Those that modify the environment where applications are executed, for example PaX now integrated into the OpenWall project[4], and those that alter the way programs are compiled. We will focus on the last groups, specially in StackGuard, StackShield, and Microsoft’s new stack smashing protection. Techniques that exploit stack based buer overflows on protected programs and environment have been presented in the past in [3], [2] and [15]. Here we’ll describe how the studied protections work, and then we’ll present four more tricks to bypass stack smashing protections, some of which are extentions of older techniques, and some we think are novel.
Large-field-of-view, high-gain, compact diode-pumped Nd:YAG amplifier (1997)

We present a compact diode-end-pumped Nd:YAG amplifier with a FWHM angular bandwidth of 100 degrees . Using a 1.064-microm probe beam, we measured a 2-pass gain of 23 (13.6dB) and a 4-pass gain of 420 (26.2dB). High-gain image amplification with such a laser amplifier is also demonstrated.
Introduction on dynamic motion of opposite and parallel steering for electric vehicle (2013)

As car manufacturers progress in creating electric based transportation, demand on the research of stability, controllability and feasibility on electric vehicle increases. The conversion of mechanical to electric does not limit to the driving propulsion, but also to the drivetrain of an electric vehicle. The electric powered and by-wire control technology allow for manufacturers to build an independent four wheels steering (i4WS) of an all-wheel drive small in wheel electric vehicle. These i4WS provides extra mobility compared to conventional vehicle such as opposite steering, parallel steering, and zero-radius steering. However before any control can be applied, a basic knowledge and specification of every modes are needed. Thus in this paper, a research solely on the introduction of dynamic motion for opposite steering and parallel steering is addressed. A simulation was done to determine the steering characteristic for opposite steering and parallel steering during steady state cornering and lane changing. The negative steer angle indicates the wheel steer at a clockwise direction while positive angle indicates rotation at counter-clockwise. Results show that opposite steering increase the yaw rotation speed while decreasing the turning radius. However, parallel steering decrease the yaw rotational speed and increase the turning radius.
A novel humidity sensor based on alumina nanowire films (2012)

Abstract Alumina nanowire (ANW) films were prepared by etching porous anodic aluminium oxide (AAO), and then humidity sensors with coplanar interdigitated electrodes based on ANWs were fabricated. The ANWs not only present tremendous surface area for water molecule adsorption but also provide efficient sites for attracting water molecules at low relative humidity (RH) levels. The sensors based on the particular morphology of ANWs with large open voids show high sensitivity and small hysteresis, and have fast response and recovery time to humidity. The capacitance rises slowly at a lower RH and increases rapidly after 70% RH, which is associated with the humidity mechanism of chemisorption at lower RH and physisorption at higher RH levels. The impendence analysis suggests that the ANWs are the main factor for sensing humidity, and AAO also contributes to humidity sensing. This study demonstrates that ANWs have promising applications in humidity monitoring.
Silver-Coated Alumina as a New Medium for Surfaced-Enhanced Raman Scattering Analysis (1989)

A new and simple substrate for inducing surface-enhanced Raman scattering (SERS) was investigated. This new SERS substrate consists of a solid support, such as a microscope slide, coated with alumina and then covered with silver. The alumina used in this work is an agglomerate-free type available in several submicron nominal particle diameters and is widely used as polishing powders. Several substrate conditions, such as the silver thickness used to coat the alumina, the amount of alumina deposited on the glass support, and the particle size of the alumina, were investigated extensively to determine the optimal experimental conditions for obtaining the SERS enhancement. In addition, it was also shown that the SERS enhancement obtained from the silver-coated alumina substrate was comparable to—or even better than—that obtained with previously used substrates. The analytical figures of merit, such as spectral features, signal reproducibility, linear dynamic range, and limits of detection, were investigated to demonstrate the analytical potential of this new substrate.
BODY TEMPERATURE REGULATION AND THERMONEUTRALITY IN RATS (1977)

Various concepts of thermoneutrality were considered for a proposed study of the role of hypothalamic amines in temperature regulation of rats. The classic definition, the ambient temperature over which metabolic rate is minimum and constant, gave a range of approximately 28 to 32°C. However, within this temperature range rats were inactive, the inactivity apparently representing a behavioural response to heat stress and itself responsible for the reduced metabolic rate; certain thermoregulatory effectors were also activated to increase heat loss. Therefore an alternative range, 18·0±1·9 (mean ± S.D.) to 28·1±1·°C, was defined in which rats displayed normal activity, behavioural thermoregulation being absent.
Rapid intestinal ischaemia-reperfusion injury is suppressed in genetically mast cell-deficient Ws/Ws rats (1999)

Ws/Ws rats have a small deletion of the c-kit gene, and are deficient in both mucosal and connective tissue-type mast cells. In this study, the role of mucosal type mast cells (MMC) in the development of intestinal ischaemia-reperfusion injury was investigated in Ws/Ws rats. Autoperfused segments of the jejunum were exposed to 60 min of ischaemia, followed by reperfusion for various time periods. The epithelial permeability was then assessed by the 51Cr-EDTA clearance rate. In the control (+/+) rats, the maximal increase in mucosal permeability was achieved at 45 min of reperfusion. In contrast, this increase was significantly and potently attenuated in the Ws/Ws rats. Mucosal alkaline phosphatase activity decreased in the control (+/+) rats, but was not altered in the Ws/Ws rats. There were no differences in mucosal myeloperoxidase activity, indicating that granulocytes did not contribute to tissue injury. These results provide direct evidence for the role of mast cells in the pathogenesis of intestinal ischaemia-reperfusion injury.
Antibodies to the vitronectin receptor (integrin alpha V beta 3) inhibit binding and infection of foot-and-mouth disease virus to cultured cells (1995)

The amino acid sequence Arg-Gly-Asp (RGD) is highly conserved on the VP1 proteins of different serotypes and subtypes of foot-and-mouth disease virus (FMDV) and is essential for cell attachment. This sequence is also found in certain extracellular matrix proteins that bind to a family of cell surface receptors called integrins. Within the Picornaviridae family, enterovirus coxsackievirus A9 also has an RGD motif on its VP1 capsid protein and has recently been shown to utilize the vitronectin receptor integrin alpha V beta 3 as a receptor on monkey kidney cells. Competition binding experiments between type A12 FMDV and coxsackievirus A9 using BHK-21 and LLC-MK2 cells revealed shared receptor specificity between these two viruses. Polyclonal anti-serum to the vitronectin receptor and a monoclonal antibody to the alpha V subunit inhibited both FMDV binding and plaque formation, while a monoclonal antibody to the beta 3 subunit inhibited virus binding. In contrast, antibodies to the fibronectin receptor (alpha 5 beta 1) or to the integrin (alpha V beta 5) had no effect on either binding or plaque formation. These data demonstrate that the alpha V beta 3 vitronectin receptor can function as a receptor for FMDV.
Damping of inter-area oscillations using energy storage (2013)

Low frequency inter-area oscillations have been identified as a significant problem in utility systems due to the potential for system damage and the resulting restrictions on power transmission over select lines. Previous research has identified real power injection by energy storage based damping control nodes as a promising approach to mitigate inter-area oscillations. In this paper, a candidate energy storage system based on UltraCapacitor technology is evaluated for damping control applications in the Western Electric Coordinating Council (WECC), and an analytical method for ensuring proper stability margins is also presented for inclusion in a future supervisory control algorithm. Dynamic simulations of the WECC were performed to validate the expected system performance. Finally, the Nyquist stability criteria was employed to derive safe operating regions in the gain, time delay space for a simple two-area system to provide guaranteed margins of stability.
GRAFT-VERSUS-LEUKEMIA EFFECT IN MHC-COMPATIBLE AND -INCOMPATIBLE ALLOGENEIC BONE MARROW TRANSPLANTATION OF RADIATION-INDUCED, LEUKEMIA-BEARING MICE (1991)

Manifestation of graft-versus-leukemia (GVL) effect in MHC-compatible and -incompatible, allogeneic bone marrow transplantation and the roles of T cell subsets contaminated in the donor bone marrow were studied using radiation-induced leukemia-bearing C3H mice maintained under specific-pathogen-free (SPF) condition. The results indicated that BMT from MHC-incompatible allogeneic (B10) donor significantly improved the survival of the treated mice as compared with that from syngeneic (C3H) donor. When donor (B10) bone marrow cells were treated with either anti-Thy 1.2 or anti-Lyt 2.2 antibody plus complement prior to BMT, a beneficial GVL effect was completely abolished. On the other hand, BMT from MHC-compatible allogeneic donors (B10.BR, CBA, AKR) failed to show an improvement in survival. However, intentional enhancement of GVH reaction by preimmunization of B10.BR donor mice with a relatively small number (10(4) approximately 10(5] of C3H spleen cells or by an addition of B10.BR lymph node cells to the donor bone marrow resulted in a significant improvement in survival. The depletion of all T cells completely abrogated the GVL effect, while the depletion of either Lyt 2+ or L3T4+ T cells from donor (B10.BR) bone marrow resulted in only partial, if any, abrogation of GVL effect. The results indicate that GVL effect observed in leukemic mice treated with allogeneic BMT from MHC-compatible (B10.BR) and -incompatible (B10) donors was totally dependent on T cells contaminated in the donor bone marrow, and suggest that the roles of T cell subsets in the induction of GVL effect were different between MHC-compatible (B10.BR) and -incompatible (B10), allogeneic BMT.
Efficient allelic exchange and transposon mutagenesis in Mycobacterium tuberculosis (1997)

A better understanding of Mycobacterium tuberculosis virulence mechanisms is highly dependent on the design of efficient mutagenesis systems. A system enabling the positive selection of insertional mutants having lost the delivery vector was developed. It uses ts-sacB vectors, which combine the counterselective properties of the sacB gene and a mycobacterial thermosensitive origin of replication and can therefore be efficiently counterselected on sucrose at 39 degrees C. This methodology allowed the construction of M. tuberculosis transposition mutant libraries. Greater than 10(6) mutants were obtained, far exceeding the number theoretically required to obtain at least one insertion in every nonessential gene. This system is also efficient for gene exchange mutagenesis as demonstrated with the purC gene: 100% of the selected clones were allelic exchange mutants. Therefore, a single, simple methodology has enabled us to develop powerful mutagenesis systems, the lack of which was a major obstacle to the genetic characterization of M. tuberculosis.