gebhart/patrepeval huggingface dataset:
Fluoro- vs hydrocarbon surfactants: Why do they differ in wetting performance? (2014)

Fluorosurfactants are the most effective compounds to lower the surface tension of aqueous solutions, but their wetting properties as related to low energy hydrocarbon solids are inferior to hydrocarbon trisiloxane surfactants, although the latter demonstrate higher surface tension in aqueous solutions. To explain this inconsistency available data on the adsorption of fluorosurfactants on liquid/vapour, solid/liquid and solid/vapour interfaces are discussed in comparison to those of hydrocarbon surfactants. The low free energy of adsorption of fluorosurfactants on hydrocarbon solid/water interface should be of a substantial importance for their wetting properties.
Animal models of Parkinson’s disease (2012)

Animal models of Parkinson's disease (PD) have been widely used in the past four decades to investigate the pathogenesis and pathophysiology of this neurodegenerative disorder. These models have been classically based on the systemic or local (intracerebral) administration of neutoxins that are able to replicate most of the pathological and phenotypic features of PD in mammals (i.e. rodents or primates). In the last decade, the advent of the 'genetic era' of PD has provided a phenomenal enrichment of the research possibilities in this field, with the development of various mammalian (mice and, more recently, rats) and non-mammalian transgenic models that replicate most of the disease-causing mutations identified for monogenic forms of familial PD. Both toxic and transgenic classes of animal PD models have their own specificities and limitations, which must be carefully taken into consideration when choosing the model to be used. If a substantial and reproducible nigrostriatal lesion is required (e.g. for testing therapeutic interventions aimed at counteracting PD-related cell death), a classic toxic model such as one based on the administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or 6-hydroxydopamine will adequately serve the purpose. On the other hand, if selected molecular mechanisms of PD pathogenesis must be investigated, transgenic models will offer invaluable insights. Therefore, until the 'perfect' model is developed, indications to use one model or another will depend on the specific objectives that are being pursued.
Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor‐α‐mediated shock (1997)

Cell surface components of pathogens, such as lipopolysaccharide (LPS), are an important signal for receptor-mediated activation of immune cells. Here we demonstrate that DNA of gram-positive and gram-negative bacteria or certain synthetic oligonucleotides displaying unmethylated CpG-motifs can trigger macrophages in vitro to induce nuclear translocation of nuclear factor-kappa B, accumulate tumor necrosis factor (TNF)-alpha mRNA and release large amounts of TNF-alpha. In vivo these events culminate in acute cytokine-release syndrome which includes systemic but transient accumulation of TNF-alpha. D-Galactosamine (DGalN)-sensitized mice succumb to lethal toxic shock due to macrophage-derived TNF-alpha resulting in fulminant apoptosis of liver cells. LPS and a specific oligonucleotide synergized in vivo as measured by TNF-alpha-release, suggesting that macrophages integrate the respective signals. The ability of macrophages to discriminate and to respond to bacterial DNA with acute release of pro-inflammatory cytokines may point out an important and as yet unappreciated sensing mechanism for foreign DNA.
Pharmacokinetics of Treprostinil Sodium Administered by 28‐Day Chronic Continuous Subcutaneous Infusion (2004)

The objective of this study was to assess the pharmacokinetics and safety of treprostinil sodium administered as a 28-day continuous subcutaneous infusion at escalating infusion rates of 2.5 to 15 ng/kg/min in normal subjects. Fourteen healthy adult volunteers received a 28-day continuous sub-cutaneous infusion of treprostinil at escalating infusion rates of 2.5, 5, 10, and 15 ng/kg/min. Doses were escalated every 7 days with no washouts between escalations. Serial plasma samples were collected predosing, during dosing, and postdosing. Samples were also collected every 3 hours on Day 7 of each dosing period to evaluate diurnal variation over a 24-hour steady-state interval. Plasma treprostinil concentration was measured by a validated liquid chromatography atmospheric pressure ionization tandem mass spectrometry (LC/MS/MS) method with a lower limit of quantitation (LLOQ) of 25 pg/mL. Distinct steady states were achieved for each of the four treprostinil doses. Linear regression analysis of mean steady-state treprostinil concentration versus targeted dose yielded a fitted line with an r(2) of 0.92. Variation in apparent plasma clearance for the four doses was small (i.e., 9.77-10.4 mL/kg/min). Consistent diurnal cycles of two peak and two trough treprostinil concentrations were observed over a 24-hour steady-state interval for each dose with peak levels 20% to 30% higher than trough levels. The terminal half-life of treprostinil was 2.93 hours. Intersubject variability for mean pharmacokinetic parameters was small (coefficients of variation ranging from 13.6%-25.5%). At clinically relevant doses, the pharmacokinetics of treprostinil were linear and dose independent with modest, consistent diurnal cycles consisting of two daily peaks and two daily troughs observed for all four doses. In addition, the elimination half-life was about 3 hours.
Determination of pharmaceutical compounds in skin by imaging matrix‐assisted laser desorption/ionisation mass spectrometry (2004)

Matrix-assisted laser desorption/ionisation (MALDI) quadrupole time-of-flight mass spectrometry (Q-TOFMS) has been used to detect and image the distribution of a xenobiotic substance in skin. Porcine epidermal tissue was treated with 'Nizoral', a medicated shampoo containing ketoconazole (+/-)-1-acetyl-4-[p-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine) as active ingredient. Following incubation for 1 h at 37 degrees C all excess formulation was washed from the surface. A cross-section of the drug-treated tissue was then blotted onto a cellulose membrane, precoated in matrix (alpha-cyano-4-hydroxycinnamic acid (CHCA)), by airspray deposition. In separate experiments the tissue surface was treated with Nizoral within a triangular former, and subsequently blotted onto a matrix-coated membrane. Sample membranes were then mounted into the recess of specialised MALDI targets with adhesive tape. All samples were analysed by MALDI-TOFMS using an Applied Biosystem 'Q-star Pulsar i' hybrid Q-TOF mass spectrometer fitted with an orthagonal MALDI ion source and imaging software. Detection of the protonated molecule was readily achievable by this technique. Treatment of the tissue within a template gave rise to images depicting the expected distribution of the drug, demonstrating that this technique is capable of producing spatially useful data. Ion images demonstrating the permeation of the applied compound into the skin were achieved by imaging a cross-sectional imprint of treated tissue. A calibration graph for the determination of ketoconazole was prepared using the sodium adduct of the matrix ion as an internal standard. This enabled construction of a quantitative profile of drug in skin. Conventional haematoxylin and eosin staining and microscopy methods were employed to obtain a histological image of the porcine epidermal tissue. Superimposing the mass spectrometric and histological images appeared to indicate drug permeation into the dermal tissue layer.
The Internet Key Exchange (IKE) (1998)

Роботу виконано на кафедрі кібербезпеки Тернопільського національного технічного університету імені Івана Пулюя Керівник роботи: кандидат технічних наук, зав. кафедри кібербезпеки Загородна Наталія Володимирівна Тернопільський національний технічний університет імені Івана Пулюя, Рецензент: д.к.н., професор Кунанець Наталія Едуардівна, Тернопільський національний технічний університет імені Івана Пулюя, кафедра комп'ютерних наук, доцент. Захист відбудеться 23 грудня 2019 р. о 9.00 годині на засіданні екзаменаційної комісії №32 у Тернопільському національному технічному університеті імені Івана Пулюя за адресою: 46001, м. Тернопіль, вул. Руська, 56, навчальний корпус №1, ауд. 806.
Epidermal growth factor and fibroblast growth factor accelerate proliferation of human hair bulb papilla cells and root sheath tibroblasts cultured in vitro (1987)

Journal Article Epidermal growth factor and fibroblast growth factor accelerate proliferation of human hair bulb papilla cells and root sheath tibroblasts cultured in vitro Get access K. Katsuoka, K. Katsuoka Department of Dermatology, University of Erlangen‐Nuernberg, Hartmannstrasse 14, D‐8520 Erlangen, F.R.G. Search for other works by this author on: Oxford Academic Google Scholar H. Schell, H. Schell Department of Dermatology, University of Erlangen‐Nuernberg, Hartmannstrasse 14, D‐8520 Erlangen, F.R.G. Search for other works by this author on: Oxford Academic Google Scholar O.P. Hornstein, O.P. Hornstein Department of Dermatology, University of Erlangen‐Nuernberg, Hartmannstrasse 14, D‐8520 Erlangen, F.R.G. Search for other works by this author on: Oxford Academic Google Scholar B. Wessel B. Wessel Department of Dermatology, University of Erlangen‐Nuernberg, Hartmannstrasse 14, D‐8520 Erlangen, F.R.G. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 116, Issue 3, 1 March 1987, Pages 464–465, https://doi.org/10.1111/j.1365-2133.1987.tb05861.x Published: 01 March 1987
Rule-base structure identification in an adaptive-network-based fuzzy inference system (1994)

We summarize Jang's architecture of employing an adaptive network and the Kalman filtering algorithm to identify the system parameters. Given a surface structure, the adaptively adjusted inference system performs well on a number of interpolation problems. We generalize Jang's basic model so that it can be used to solve classification problems by employing parameterized t-norms. We also enhance the model to include weights of importance so that feature selection becomes a component of the modeling scheme. Next, we discuss two ways of identifying system structures based on Jang's architecture: the top-down approach, and the bottom-up approach. We introduce a data structure, called a fuzzy binary boxtree, to organize rules so that the rule base can be matched against input signals with logarithmic efficiency. To preserve the advantage of parallel processing assumed in fuzzy rule-based inference systems, we give a parallel algorithm for pattern matching with a linear speedup. Moreover, as we consider the communication and storage cost of an interpolation model. We propose a rule combination mechanism to build a simplified version of the original rule base according to a given focus set. This scheme can be used in various situations of pattern representation or data compression, such as in image coding or in hierarchical pattern recognition.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Frequency stabilized 622-Mb/s 16-channel optical FDM system and its performance in 1.3/1.55-μm zero-dispersion fiber transmission (1995)

A study has been conducted on a densely multiplexed 16-channel optical FDM system. A transmitter contains 16 two-section MQW DFB-LD's and a star coupler. An automatic optical multi-frequency controller stabilizes each LD of 10 GHz spacing within /spl plusmn/100-MHz accuracy. A receiver consists of heterodyne-delay-demodulators using a polarization diversity. Any desired channel can be tuned by a novel frequency discriminator with no insensitive frequency region. The system has successfully transmitted 622 Mb/s-16-channel HDTV signals through 110 km long 1.3 /spl mu/m-zero-dispersion fiber. We have also studied error rate degradation due to four-wave mixing in a 1.55 /spl mu/m-dispersion-shifted-fiber. Experimental results have revealed the allowable total input power to be +2 dBm for dispersion-shifted fibers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A prospective, randomized clinical study on the effects of an amine fluoride/stannous fluoride toothpaste/mouthrinse on plaque, gingivitis and initial caries lesion development in orthodontic patients (2005)

The aim of this study was to examine the effect of combined use of a toothpaste/mouthrinse containing amine fluoride/stannous fluoride (AmF/SnF2; meridol) on the development of white spot lesions, plaque, and gingivitis on maxillary anterior teeth in orthodontic patients. A prospective, randomized, double-blind study with 115 orthodontic patients (42 males and 73 females, average age 14.4 years, drop outs 18) was designed. Group A (50) brushed twice daily with an AmF/SnF2 toothpaste (1400 ppm F) and rinsed every evening with an AmF/SnF2 solution (250 ppm F). Group B (47) brushed twice daily with a sodium fluoride (NaF) toothpaste (1400 ppm F) and rinsed every evening with a NaF solution (250 ppm F). Visible plaque index (VPI), gingival bleeding index (GBI) and white spot lesion index (WSL) were recorded on the six maxillary anterior teeth at bonding and after debonding, and evaluated with t tests. In group A no significant differences between bonding and debonding were recorded for WSL (1.02 +/- 0.08 versus 1.05 +/- 0.13, P = 0.14), VPI (0.10 +/- 0.21 versus 0.12 +/- 0.21, P = 0.66) or GBI (0.13 +/- 0.21 versus 0.16 +/- 0.22, P = 0.47), whereas statistically significant differences were found in group B between bonding and debonding for WSL (1.00 +/- 0.02 versus 1.08 +/- 0.17, P = 0.01), VPI (0.06 +/- 0.13 versus 0.17 +/- 0.25, P = 0.01) and GBI (0.06 +/- 0.12 versus 0.16 +/- 0.21, P = 0.01). The increase in lesions on the upper anterior teeth was 4.3 per cent in group A and 7.2 per cent in group B. It was concluded that the combined use of an AmF/SnF2 toothpaste/mouthrinse had a slightly more inhibitory effect on white spot lesion development, plaque and gingivitis on maxillary anterior teeth during fixed orthodontic treatment compared with NaF.
Synthesis of Cyclopentadiene Ligands with Fluorinated Substituents by Reaction of Cobaltocene with Fluoroalkenes (2014)

Abstract The hitherto difficult introduction of fluorinated and perfluorinated substituents onto cyclopentadienes is possible by the simple reaction of cobaltocene with fluorinated olefins(CF 2 =CFX; X = I, Br, Cl, CF 3 ). Two structurally different products, that is, a mononuclear complex and a dinuclear complex, are formed. Reaction of cobaltocene with iodotrifluoroethene yields η 5 ‐cyclopentadienyl‐η 4 ‐trifluorovinylcyclopentadienecobalt and cobaltocenium iodide. Reaction of cobaltocenium salts with hexafluoropropene and trifluorovinyllithium represents an alternative high‐yielding synthesis of the corresponding compounds. The molecular structures of three compounds were elucidated by using single‐crystal X‐ray diffraction.
High dielectric constant oxides (2004)

The scaling of complementary metal oxide semiconductor (CMOS) transistors has led to the silicon dioxide layer used as a gate dielectric becoming so thin (1.4 nm) that its leakage current is too large. It is necessary to replace the SiO2 with a physically thicker layer of oxides of higher dielectric constant (κ) or ‘high K’ gate oxides such as hafnium oxide and hafnium silicate. Little was known about such oxides, and it was soon found that in many respects they have inferior electronic properties to SiO2, such as a tendency to crystallise and a high concentration of electronic defects. Intensive research is underway to develop these oxides into new high quality electronic materials. This review covers the choice of oxides, their structural and metallurgical behaviour, atomic diffusion, their deposition, interface structure and reactions, their electronic structure, bonding, band offsets, mobility degradation, flat band voltage shifts and electronic defects. The use of high K oxides in capacitors of dynamic random access memories is also covered.
Multicast Tree Generation in Networks with Asymmetric Links (1996)

We formulate the problem of multicast tree generation as one of computing a directed Steiner tree of minimal cost. In this context, we present a polynomial-time algorithm that provides for tradeoff selection, using a single parameter , between the tree-cost (Steiner cost) and the runtime efficiency. Further, the same algorithm may be used for delay optimization or tree-cost minimization simply by configuring the value of appropriately. We present theoretical and experimental analysis characterizing the problem and the performance of our algorithm. Theoretically, we (1) show that it is highly unlikely that there exists a polynomial-time algorithm with a performance guarantee of constant times optimum cost, (2) introduce metrics for measuring the asymmetry of graphs, and (3) show that the worst-case cost of the tree produced by our algorithm is at most twice the optimum cost times the asymmetry, for two of these asymmetry metrics. For graphs with bounded asymmetry, this gives constant ...
A newt ribozyme: a catalytic activity in search of a function. (1992)

We analyzed the cleavage properties and the transcription regulation of the newt (Triturus vulgaris meridionalis) self-cleaving RNA. In vitro self-cleavage of model oligoribonucleotides occurs within a double hammerhead structure. In addition, an entire ribozyme molecule, as well as its catalytic domain, "trans-cleaves" in vitro appropriate oligoribonucleotide substrates. Signals encoded within the ribozyme DNA sequences regulate the ribozyme transcription, which is RNA polymerase II dependent. Finally, the deduced secondary structure of the self-cleaving RNA appears to be conserved in evolutionarily distant newt species. These features suggest that the newt ribozyme could play some role in the cell, possibly related to its cleavage properties.
Anorganic bovine bone and analogs of bone mineral as implants for craniofacial surgery: a literature review. (1998)

Hydroxyapatite compounds and a new anorganic bovine bone mineral are materials that offer an alternative to autologous bone grafting. Ceramic hydroxyapatite implants are limited in their usefulness due to difficulty in contouring the cortical form and the tendency for the granular form to exist outside the reconstruction site. These limitations have been overcome by the advent of a hydroxyapatite cement paste exhibiting good biocompatibility, contour manipulation, implant stability and osseoinduction. Preliminary studies indicate that a new resorbable anorganic bovine bone mineral with a chemical composition and structure similar to human bone promotes initial bony healing more readily than its synthetic hydroxyapatite counterpart, and therefore may serve as an excellent alternative for craniofacial reconstruction.
Reconstitution of the Entry Point of Plant Phenylpropanoid Metabolism in Yeast (Saccharomyces cerevisiae) (2004)

Phenylalanine ammonia lyase (PAL), cinnamate 4-hydroxylase (C4H), and the C4H redox partner cytochrome p450 reductase (CPR) are important in allocating significant amounts of carbon from phenylalanine into phenylpropanoid biosynthesis in plants. It has been proposed that multienzyme complexes (MECs) containing PAL and C4H are functionally important at this entry point into phenylpropanoid metabolism. To evaluate the MEC model, two poplar PAL isoforms presumed to be involved in either flavonoid (PAL2) or in lignin biosynthesis (PAL4) were independently expressed together with C4H and CPR in Saccharomyces cerevisiae, creating two yeast strains expressing either PAL2, C4H and CPR or PAL4, C4H and CPR. When [(3)H]Phe was fed, the majority of metabolized [(3)H]Phe was incorporated into p-[(3)H]coumarate, and Phe metabolism was highly reduced by inhibiting C4H activity. PAL alone expressers metabolized very little phenylalanine into cinnamic acid. To test for intermediate channeling between PAL and C4H, we fed [(3)H]Phe and [(14)C]cinnamate simultaneously to the triple expressers, but found no evidence for channeling of the endogenously synthesized [(3)H]cinnamate into p-coumarate. Therefore, efficient carbon flux from Phe to p-coumarate via reactions catalyzed by PAL and C4H does not appear to require channeling through a MEC in yeast, and instead biochemical coupling of PAL and C4H is sufficient to drive carbon flux into the phenylpropanoid pathway. This may be the primary mechanism by which carbon allocation into phenylpropanoid metabolism is controlled in plants.
Evaluations of biomarkers associated with 5-FU sensitivity for non-small-cell lung cancer patients postoperatively treated with UFT (2006)

The sensitivity to 5-fluorouracil (5-FU) has been reported to be associated with target molecule thymidylate synthase (TS), fluoropyrimidine-metabolising enzymes such as orotate phosphoribosyltransferase (OPRT), and dihydropyrimidine dehydrogenase (DPD). We performed an immunohistochemical study on the clinical significance of TS, OPRT, and DPD expression using 151 resected non-small-cell lung cancer (NSCLC) patients postoperatively treated with a combination of tegafur and uracil (UFT). Eighty-two carcinomas were TS-positive, 105 carcinomas were OPRT-positive, 68 carcinomas were DPD-positive. No correlation was observed in the HSCORE between the TS and OPRT expression (r=0.203), between the TS and DPD expression (r=0.098), or between the OPRT and DPD expression (r=0.074). Regarding the survival of NSCLC patients treated with UFT, the 5-year survival rate of patients with TS-negative tumours was significantly higher than that with TS-positive tumours (P=0.0133). The 5-year survival rate of patients with OPRT-positive stage II to III tumours was significantly higher than that with OPRT-negative stage II to III tumours (P=0.0145). In addition, the 5-year survival rate of patients with DPD-negative tumours was also significantly higher than that with DPD-positive tumours (P=0.0004). A Cox multivariate regression analysis revealed the TS status (hazard ratio 2.663; P=0.0003), OPRT status (hazard ratio 2.543; P=0.0005), and DPD status (hazard ratio 2.840; P<0.0001) to all be significant prognostic factors for the survival of resected NSCLC patients postoperatively treated with UFT.
Metallization of Polymers Using Plasma‐Enhanced Chemical Vapor Deposited Titanium Nitride as Interlayer (1997)

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