gebhart/patrepeval huggingface dataset:
Effect of hyaluronidase on experimental cerebral infarct size and mortality. (1982)

The goal of this investigation was to determine whether hyaluronidase administration can alter the size, morbidity, and mortality of experimental acute cerebral infarctions. Accordingly, the left common carotid artery was occluded in 1205 ether-anesthetized Mongolian gerbils. The gerbils were randomized into hyaluronidase-treated (4000 National Formulary units per kg., intravenously, 5 minutes after occlusion) or control groups. All were examined for clinical signs of cerebrovascular accident three times during the 24 hours and then decapitated, and each hemibrain was analyzed for its total creatine kinase activity. In the control group, 90 of 601 gerbils died, whereas in the hyaluronidase-treated group only 61 of 604 gerbils died. This reduction in mortality was highly significant (chi 2 = 6.53, p less than 0.02). In the surviving gerbils with cerebrovascular accidents, infarct size was calculated by creatine kinase depletion (normal right hemibrain creatine kinase minus infarcted left hemibrain creatine kinase divided by right hemibrain creatine kinase and corrected for "residual" (nondepletable) creatine kinase). In controls, infarct size was 36.5 +/- 1.8 per cent (n = 105), and in the hyaluronidase-treated gerbils it was significantly lower, 31.4 +/- 1.7 per cent (n = 117, p less than 0.05). Thus, in gerbils with experimental cerebrovascular accidents, hyaluronidase significantly reduced mortality (by one-third) and reduced "enzymatic" infarct size by 14.0 +/- 4.6 per cent (p less than 0.01).
Acute Treatment of Intractable Migraine With Sphenopalatine Ganglion Electrical Stimulation (2009)

This study suggests a possible role for SPG stimulation in the treatment of refractory migraine headaches.
Human corneal and conjunctival epithelia produce a mucin-like glycoprotein for the apical surface. (1995)

Human corneal and conjunctival epithelia produce a molecule, similar in size, cellular localization, and distribution to the mucin-like glycoprotein of rat ocular surface epithelium. These data suggest that the entire ocular surface epithelium produces mucins for the tear film.
Is hypovitaminosis D one of the environmental risk factors for multiple sclerosis? (2010)

The role of hypovitaminosis D as a possible risk factor for multiple sclerosis is reviewed. First, it is emphasized that hypovitaminosis D could be only one of the risk factors for multiple sclerosis and that numerous other environmental and genetic risk factors appear to interact and combine to trigger the disease. Secondly, the classical physiological notions about vitamin D have recently been challenged and the main new findings are summarized. This vitamin could have an important immunological role involving a number of organs and pathologies, including autoimmune diseases and multiple sclerosis. Furthermore, human requirements for this vitamin are much higher than previously thought, and in medium- or high-latitude countries, they might not be met in the majority of the general population due to a lack of sunshine and an increasingly urbanized lifestyle. Thereafter, the different types of studies that have helped to implicate hypovitaminosis D as a risk factor for multiple sclerosis are reviewed. In experimental autoimmune encephalomyelitis, vitamin D has been shown to play a significant immunological role. Diverse epidemiological studies suggest that a direct chain of causality exists in the general population between latitude, exposure to the sun, vitamin D status and the risk of multiple sclerosis. New epidemiological analyses from France support the existence of this chain of links. Recently reported immunological findings in patients with multiple sclerosis have consistently shown that vitamin D significantly influences regulatory T lymphocyte cells, whose role is well known in the pathogenesis of the disease. Lastly, in a number of studies on serum levels of vitamin D in multiple sclerosis, an insufficiency was observed in the great majority of patients, including at the earliest stages of the disease. The questionable specificity and significance of such results is detailed here. Based on a final global analysis of the cumulative significance of these different types of findings, it would appear likely that hypovitaminosis D is one of the risk factors for multiple sclerosis.
Cell Adhesion Molecules and Cancer Metastasis (1997)

The adhesive interaction between tumor cells and host cells or the extracellular matrix plays a crucial role in metastasis formation. Therefore, understanding the mechanism controlling metastasis may assist in the development of antimetastatic therapy. We have used synthetic or recombinant polypeptide analogues containing the Arg-Gly-Asp (RGD) sequence found in the functional domains of fibronectin, such as poly(RGD) or CH-271, to regulate the mechanisms involved in cell adhesion during the metastatic process. Poly(RGD) inhibited experimental lung and liver metastasis effectively when coinjected i.v. with various types of tumors. In a model of spontaneous lung metastasis using the B16-BL6 melanoma, repeated administration of this polypeptide before or after surgical excision of the primary tumor resulted in a significant inhibition of tumor metastasis without affecting the growth of the primary tumor and substantially prolonged the survival time of mice. The mechanism responsible for the inhibition of tumor metastasis by the polypeptides is at least partly associated with the ability to interfere with cellular functions such as adhesiveness, motility and invasiveness in the process of metastasis. Combined treatment of the CH-271 fusion polypeptide and anticancer drugs, i.e., anti-adhesion therapy combined with chemotherapy, caused a marked inhibition of lung and liver metastasis of tumors as compared with either treatment alone or with the control. In contrast, the promotion of tumor cell interaction with immune cells via cell adhesion molecules, which differs from the anti-adhesive mechanism, may lead to the induction of anti-tumor immune responses and, consequently, to the inhibition of tumor metastasis. The transfection of the gene of the B7-1 adhesion molecule into tumor cells (B16-BL6 or K1735-M2 melanoma) resulted in the remarkable reduction of lung metastasis caused by the i.v. injection into mice. Immunization of B7-transfected tumor was effective as a tumor vaccine for preventing the metastasis of B7 negative original tumor cells. Thus, the regulation of the adhesive interaction with tumor cells may provide a new and promising approach for the control and prevention of cancer metastasis.
Fabrication of Gold Microtubes and Microwires in High Aspect Ratio Capillary Arrays (2004)

In this communication, we describe the sequential deposition of materials in capillaries as a means to produce self-assembled three-dimensional gold microtubes, hollow gold microwires, and microtube and microwire arrays with unprecedented aspect ratios. The initial application of this technique is the fabrication of an array of microwires within a silica capillary array. The physical characteristics of these microwires are characterized via SEM, electrochemistry, and electrogenerated chemiluminescence emission.
Accuracy of dual-source CT in the characterisation of non-calcified plaque: use of a colour-coded analysis compared with virtual histology intravascular ultrasound (2009)

Non-invasive assessment of plaque volume and composition is important for risk stratification and long-term studies of plaque stabilisation. Our aim was to evaluate dual-source computed tomography (DSCT) and colour-coded analysis in the quantification and classification of coronary atheroma. DSCT and virtual histology intravascular ultrasound (IVUS-VH) were prospectively performed in 14 patients. 22 lesions were compared in terms of plaque volume, maximal per cent vessel stenosis and percentages of fatty, fibrous or calcified components. Plaque characterisation was performed with software that automatically segments luminal or outer vessel boundaries and uses CT attenuation for a colour-coded plaque analysis. Good correlation was found for per cent vessel stenosis in DSCT (53+/-13%) and IVUS (51+/-14%; r(2) = 0.70). Mean volumes for entire plaque and non-calcified atheroma were 68.5+/-33 mm(3) and 56.7+/-30 mm(3), respectively, in DSCT and 60.8+/-29 mm(3) and 55.8+/-26 mm(3), respectively, in IVUS. Mean percentages of fatty, fibrous or calcified components were 28.2+/-6%, 53.2+/-9% and 18.7+/-13%, respectively, in DSCT and 29.9+/-5%, 55.3+/-12% and 14.4+/-9%, respectively, in IVUS-VH. Significant overestimation was present for the entire plaque and the volume of calcified plaque (p = 0.03; p = 0.0004). Although good correlation with IVUS was obtained for the entire plaque (r(2) = 0.76) and non-calcified plaque volume (r(2) = 0.84), correlation proved very poor and insignificant for percentage plaque composition. Interclass correlation coefficients for non-calcified plaque volume and percentages of fatty, fibrous or calcified components were 0.99, 0.99, 0.95 and 0.98, respectively, and intraclass coefficients were 0.98, 0.93, 0.98 and 0.99, respectively. We found that using Hounsfield unit-based analysis, DSCT allows for accurate quantification of non-calcified plaque. Although percentage plaque composition proves highly reproducible, it is not correlated with IVUS-VH.
Identification of Apo B-100 segments mediating the interaction of low density lipoproteins with arterial proteoglycans. (1988)

The interactions of low density lipoprotein (LDL) and apolipoprotein (apo) B-100 segments with chondroitin-6-SO4 rich aortic proteoglycans aggregate (CSPG) were studied by using quantitative frontal elution affinity chromatography. The affinity of the agarose-CSPG was higher for LDL than for very low density lipoprotein and high density lipoprotein was not bound. LDL from different individuals had dissociation coefficients (Kd) from 28 to 179 nM. Experiments with tryptic hydrolysates of apo B suggested that the capacity of LDL to bind with CSPG resides in the protein. Nine apo B-100 hydrophilic peptides, 12 to 26 amino acids long, were selected, and three were found to interact with the agarose-bound CSPG: apo B P-1 (LRKHKLIDVISMYRELLKDLSKEA, residues 4230 to 4254), apo B P-2 (RLTRKRGLKLATALSLSNK, residues 3359 to 3377), and apo B P-11 (RQVSHAKEKLTALTKK, residues 2106 to 2121). These peptides competed with LDL for binding to the agarose-bound and soluble CSPG; apo B P-2 was the most effective. This correlates with Kd values: 63, 86, and 82 microM for apo B P-2, P-1, and P-11, respectively. The peptides shared an excess of positive-charged side chains. Apo B P-2 belongs to the lys- and arg-rich, LDL-receptor domain. Apo E also binds to the agarose-proteoglycan. The results suggest that apo B regions with sequences and charge distributions analogous to those of residues 3359 to 3377, 4230 to 4254, and 2106 and 2121 are among those responsible for the interaction of LDL with intima-media CSPG.
Comparison of Ultrathin X-Ray Window Designs (1994)

In order to fabricate entrance windows for soft x-ray detectors, various technologies have been developed. Depending on the x-ray-detector type and the environment in which the windows are used, entrance windows must meet several, often contradictory, requirements: while good pressure tolerance and durability as well as gas tightness require thicker structures, good x-ray transmission can only be achieved with thin membranes. In this paper, the suitability of different window types for various applications is discussed. The applicability discussion is based on the results of tests performed on prototype windows, as well as on calculated and measured x-ray transmission properties. A comparative study of endurance vs transmission properties of some candidate membrane materials is also presented. Test results include pressure tolerance and leakage rates as well as some measurements of radiation damage to the window materials. The window technologies presented include coated polyimide membranes with two different supporting schemes as well as submicrometer beryllium membranes.
Bioactivity of marine organisms. Part 3. Screening of marine algae of Indian coast for biological activity (1991)

Ethanolic extracts from Indian marine algae have been tested for anti-viral, anti-bacterial, anti-fungal, anti-fertility, hypoglycaemic and a wide range of pharmacological activities. Of 34 species investigated 17 appeared biologically active. Six were diuretic, 3 hypoglycaemic, 3 hypotensive, 4 exhibited anti-implantation activity, cytokinin activity was observed in one and one showed adrenergic blocking action. The extracts neither, had anti-bacterial, anti-fungal and anti-viral activities nor were toxic
A perceptron network for functional identification and control of nonlinear systems (1993)

Tracking control of a general class of nonlinear systems using a perceptron neural network (PNN) is presented. The basic structure of the PNN and its training law are first derived. A novel discrete-time control strategy is introduced that employs the PNN for direct online estimation of the required feedforward control input. The developed controller can be applied to both discrete- and continuous-time plants. Unlike most of the existing direct adaptive or learning schemes, the nonlinear plant is not assumed to be feedback linearizable. The stability of the neural controller under ideal conditions and its robust stability to inexact modeling information are rigorously analyzed.
Epidemiology of Community-AssociatedClostridium difficileInfection, 2009 Through 2011 (2013)

Most patients with community-associated CDI had recent outpatient health care exposure, and up to 36% would not be prevented by reduction of antibiotic use only. Our data support evaluation of additional strategies, including further examination of C difficile transmission in outpatient and household settings and reduction of proton pump inhibitor use.
Constellation (1998)

Article Constellation: a wide-range wireless motion-tracking system for augmented reality and virtual set applications Share on Authors: Eric Foxlin InterSense Inc. InterSense Inc.View Profile , Michael Harrington InterSense Inc. InterSense Inc.View Profile , George Pfeifer InterSense Inc. InterSense Inc.View Profile Authors Info & Claims SIGGRAPH '98: Proceedings of the 25th annual conference on Computer graphics and interactive techniquesJuly 1998 Pages 371–378https://doi.org/10.1145/280814.280937Online:24 July 1998Publication History 107citation2,308DownloadsMetricsTotal Citations107Total Downloads2,308Last 12 Months61Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
QuickDraw (2012)

We present QuickDraw, a prototype sketch-based drawing tool, that facilitates drawing of precise geometry diagrams that are often drawn by students and academics in several scientific disciplines. Quickdraw can recognize sketched diagrams containing components such as line segments and circles, infer geometric constraints relating recognized components, and use this information to beautify the sketched diagram. Beautification is based on a novel algorithm that iteratively computes various sub-components of the components using an extensible set of deductive rules. We conducted a user study comparing QuickDraw with four state-of-the-art diagramming tools: Microsoft PowerPoint, Cabri II Plus, Geometry Expressions and Geometer's SketchPad. Our study demonstrates a strong interest among participants for the use of sketch-based software for drawing geometric diagrams. We also found that QuickDraw enables users to draw precise diagrams faster than the majority of existing tools in some cases, while having them make fewer corrections.
SET8 expression is associated with overall survival in gastric cancer (2015)

SET8, a member of the SET domain-containing methyl-transferase, has been implicated in various biological processes. In this study, SET8 was immunostained in 100 samples of gastric cancer tissues and semi-quantified using the HSCORE method to determine the predictive value of SET8 expression levels for gastric cancer outcome. The relationship between SET8 expression and the 5-year survival rate of gastric cancer patients was assessed. High expression of SET8 was associated with a shorter survival time in gastric cancer patients, and the level of SET8 expression was found to be an independent predictor of gastric cancer outcome (relative risk = 1.939; 95% confidence interval = 1.025-3.668; P = 0.042). Analysis of SET8 levels may help in the identification of patient subgroups that are at high risk for poor disease outcomes.
Slow aggregation of colloidal silica (1987)

We report the results of elastic and quasielastic light scattering measurements on dilute aggregates of colloidal silica. The elastic scattering measurements indicate a fractal dimension of 2.05\ifmmode\pm\else\textpm\fi{}0.06, in agreement with previous results, but the quasielastic measurements demonstrate several novel characteristics. First, it is found that the linewidth \ensuremath{\Gamma} scales as a fractional power, \ensuremath{\Gamma}\ensuremath{\sim}${q}^{2.7}$, of the momentum transfer q. Second, the inverse average relaxation time, defined as the integral of the field autocorrelation function, does not scale with the same power of q as the linewidth, implying that the autocorrelation functions cannot be scaled by a single nondimensioned time. Third, ``stretched'' exponential behavior is found for the long-time behavior of the autocorrelation function. These observations are interpreted in terms of a power-law polydisperse ensemble of aggregate clusters, with a number distribution of the form N(m)\ensuremath{\sim}${m}^{\mathrm{\ensuremath{-}}\ensuremath{\tau}}$, where \ensuremath{\tau}=1.9--2. Finally, the kinetics of growth are studied and the average radius is found to grow exponentially with time. These results are shown to be consistent, in part, with the predictions of the Smoluchowski equation and with simulations of aggregation.
Human TROP-2 is a tumor-associated calcium signal transducer (1998)

Trop-2/EGP-1/GA733-1 is a recently identified cell surface glycoprotein highly expressed by human carcinomas. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Thus, we investigated whether Trop-2 might be a functional signaling molecule. Using the fluorescent probe Fura-2, we assayed the cytoplasmic calcium levels in human cancer cells stimulated with anti-Trop-2 or control antibodies. Three anti-Trop-2 MAbs, Rs7-7G11, MOv16 and 162-46.2 specifically induced a transient intracellular calcium level increment in up to 40% of the experiments performed. Polyclonal antisera recognizing recombinant Trop-2 molecules possessed a much lower stimulation efficiency. The average latency of antibody-induced Ca2+ rise for OvCa-432 cells was 64+/-26 sec. Internal Ca2+ concentrations reached peaks of 190+/-24 nM vs. basal levels of 61+/-4 nM and returned to baseline within 193+/-37 sec. Similar values were obtained in MCF-7 cells. For comparison, stimulation of P2-purinergic receptors on MCF-7 and OvCa-432 cells induced a Ca2+ rise in most cases, leading to average internal Ca2+ concentrations of 297+/-41 and 391+/-39 nM, respectively. Our findings show that Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand.
Differential roles of VLA‐4(CD49d/CD29) and LFA‐1(CD11a/CD18) integrins and E‐ and P‐selectin during developing and established active or adoptively transferred adjuvant arthritis in the rat (2003)

The role of the integrins VLA-4 and LFA-1 and of the selectin adhesion molecules in autoimmune arthritis was investigated. Adjuvant arthritis was induced in Lewis rats by active immunization (s.c.) with Mycobacterium butyricum or by adoptive transfer of immune T cells. With active adjuvant arthritis, Lewis rats develop maximal polyarticular joint inflammation and migration of radiolabelled (111In and 51Cr) blood neutrophils and monocytes to the joints 14 days post Mycobacterium butyricum immunization. Using blocking monoclonal antibodies we osbserved that at this stage monocyte recruitment was dependent (85%) on P-selectin plus VLA-4 (alpha4B1) and neutrophil recruitment depended (> 80%) on P-selectin plus LFA-1 (CD11a/CD18). E-selectin played a minimal role in inflammatory cell recruitment to the already inflamed joint. In contrast, during the development of active adjuvant arthritis, blockade of P-selectin beginning at day 5 post-immunization had no effect on subsequent arthritis. However, E-selectin blockade at this stage reduced arthritic scores by 70% (P < 0.01) and combined E-selectin plus VLA-4 blockade prevented development of arthritis. Either treatment nearly abolished neutrophil and monocyte recruitment to joints at day 14 and prevented cartilage damage. VLA-4 blockade alone was less effective. Adoptive T-cell transfer of adjuvant arthritis to naive rats employed spleen/lymph node lymphocytes from Mycobacterium butyricum immunized rats stimulated with Concanavalin A in vitro (48 h). E-selectin +/- P-selectin blockade had no effect on the development of adoptive arthritis. However, VLA-4 integrin blockade inhibited adoptive arthritis severity by 55% (P < 0.01). LFA-1 blockade had no effect. In adoptive adjuvant arthritis, inhibition of arthritis clinically and by histology was essentially complete (> 90%) when E- and P-selectin blockade was combined with VLA-4 blockade. Thus, in the development of actively induced arthritis E-selectin plays an important role, likely mediating early antigen reactive T-cell recruitment to joints. In contrast, VLA-4 and multiple selectin mechanisms are involved in arthritis induction by ex vivo restimulated arthritogenic T cells. Furthermore, in actively induced adjuvant arthritis, P- and E-selectin and VLA-4 are differently important in the initiation of arthritis, and at the time of fully developed joint inflammation.
Plant Embryo Culture (2011)

A great fascination for biologists, the study of embryo development provides indispensable information concerning the origins of the various forms and structures that make up an organism, and our ever