gebhart/patrepeval huggingface dataset:
Fuzzy querying of incomplete, imprecise, and heterogeneously structured data in the relational model using ontologies and rules (2005)

In this paper, we present a new method, called multiview fuzzy querying, which permits to query incomplete, imprecise and heterogeneously structured data stored in a relational database. This method has been implemented in the MIEL software. MIEL is used to query the Sym'Previus database which gathers information about the behavior of pathogenic germs in food products. In this database, data are incomplete because information about all possible food products and all possible germs is not available; data are heterogeneous because they come from various sources (scientific bibliography, industrial data, etc); data may be imprecise because of the complexity of the underlying biological processes that are involved. To deal with heterogeneity, MIEL queries the database through several views simultaneously. To query incomplete data, MIEL proposes to use a fuzzy set, expressing the query preferences of the user. Fuzzy sets may be defined on a hierarchized domain of values, called an ontology (values of the domain are connected using the a kind of semantic link). MIEL also proposes two optional functionalities to help the user query the database: i) MIEL can use the ontology to enlarge the querying in order to retrieve the nearest data corresponding to the selection criteria; and ii) MIEL proposes fuzzy completion rules to help the user formulate his/her query. To query imprecise data stored in the database with fuzzy selection criteria, MIEL uses fuzzy pattern matching.
Fine Needle Aspiration Biopsy with Adjunct Immunohistochemistry in Intraocular Tumor Management (2005)

FNAB is a safe, sensitive and specific method of establishing a tissue diagnosis in a subset of patients with solid intraocular tumors. The routine use of immunohistochemical stain ing increases the diagnostic utility of the technique and may change clinical management.
Clinical and Genetic Findings of Turkish Hypophosphatasia Cases (2017)

Because of the respiratory problems, especially the lung hypoplasia, the clinical course is poor in cases with the perinatal lethal form of HPP. Some minor abnormalities such as mild short stature and osteopenia could be observed in asymptomatic heterozygote carriers. Laboratory findings were normal in these cases.
CD133: a stem cell biomarker and beyond (2013)

Cancer stem cells (CSCs) or tumor initiating cells (TICs) contribute to tumorigenesis, metastasis, recurrence and chemoresistance. CD133, a pentaspan membrane glycoprotein, has been used as a stem cell biomarker for isolation of stem-like cells from a variety of normal and pathological tissues as well as cell lines since its discovery in 1999. Recent studies are focusing on the functionality of CD133. In this review, we summarize new insights into CD133 regulation and the involvement of CD133 in cell self-renewal, tumorigenesis, metastasis, resistance, metabolism, differentiation, autophagy, apoptosis, and regeneration.
L1CAM expression in endometrial carcinomas is regulated by usage of two different promoter regions (2010)

Our results, for the first time, provide evidence that the L1CAM gene has two functionally active promoter sites that are used in a cell-type specific manner. Slug and β-catenin are involved L1CAM transcriptional regulation. Nevertheless, Slug rather than β-catenin levels are correlated with L1CAM expression in EC cell lines. Our findings suggest that the L1CAM transcriptional regulation is more complex than anticipated and this study provides the basis for a better understanding of L1CAM regulation in non-neuronal/tumor cells.
Glycogen Synthase Kinase 3β Regulates Cell Death Induced by Synthetic Triterpenoids (2008)

The induction of programmed cell death in premalignant or malignant cancer cells by chemopreventive agents could be a valuable tool to control prostate cancer initiation and progression. In this work, we present evidence that the C-28 methyl ester of the synthetic oleanane triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO-Me) induces cell death in androgen-responsive and unresponsive human prostate cancer cell lines at nanomolar and low micromolar concentrations. CDDO-Me induced caspase-3, caspase-8, and caspase-9 activation; poly(ADP-ribose) polymerase cleavage; internucleosomal DNA fragmentation; and loss of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction in PC3 and DU145 cells. However, caspase-3 and caspase-8 inhibition by Z-DEVD-fmk and Z-IETD-fmk, respectively, or general caspase inhibition by BOC-D-fmk or Z-VAD-fmk did not rescue loss of cell viability induced by CDDO-Me, suggesting the activation of additional caspase-independent mechanisms. Interestingly, CDDO-Me induced inactivating phosphorylation at Ser(9) of glycogen synthase kinase 3beta (GSK3beta), a multifunctional kinase that mediates essential events promoting prostate cancer development and acquisition of androgen independence. The GSK3 inhibitor lithium chloride and, more effectively, GSK3 gene silencing sensitized PC3 and DU145 prostate cancer cells to CDDO-Me cytotoxicity. These data suggest that modulation of GSK3beta activation is involved in the cell death pathway engaged by CDDO-Me in prostate cancer cells.
Terlipressin Continuous Infusion: Please Mind the Solvent! (2009)

Full text available
Myeloproliferative Neoplasm (MPN) Symptom Assessment Form Total Symptom Score: Prospective International Assessment of an Abbreviated Symptom Burden Scoring System Among Patients With MPNs (2012)

The MPN-SAF TSS is a concise, valid, and accurate assessment of MPN symptom burden with demonstrated clinical utility in the largest prospective MPN symptom study to date. This new prospective scoring method may be used to assess MPN symptom burden in both clinical practice and trial settings.
The purification and properties of butyryl-coenzyme A dehydrogenase from Peptostreptococcus elsdenii (1971)

Butyryl-CoA dehydrogenase prepared by a simple procedure from Peptostreptococcus elsdenii has a molecular weight of approx. 150000. The enzyme has FAD as its prosthetic group. The amino acid analysis is reported. This enzyme, like most of the corresponding mammalian ones, is green. The absorption band at 710nm can be abolished irreversibly by dithionite reduction and air reoxidation; it can be abolished reversibly by phenylmercuric acetate or potassium bromide. The enzyme as isolated appears to be a mixture of a green and a yellow form, both of which are active. This view is supported by the variable ;greenness' of different preparations and the biphasic curve obtained in anaerobic spectrophotometric titrations with dithionite. It can be calculated from the titration results that fully green enzyme would have a peak-to-peak absorption ratio (E(710)/E(430)) as great as 0.54. The green form is much less rapidly reduced by dithionite than the yellow form, but is nevertheless much more readily reduced by dithionite than the enzyme from pig liver. It is also more readily reoxidized by air and shows less tendency to form a semiquinone. Treatment with sodium borohydride produces an unusual reduced species that is probably the 3,4-dihydroflavin.
Vitamin D and Hypertension (2009)

Early experimental studies have suggested that vitamin D may be involved in the regulation of blood pressure (BP) and the pathogenesis of hypertension through its effects on calcium homeostasis, vascular smooth muscle cells and endothelial cells, and activity of the renin-angiotensin system (RAS). Human studies have shown a possible link between inadequate vitamin D status and elevated BP or higher prevalence of hypertension.  Due to limited data from well-designed prospective studies, it remains unsettled whether low vitamin D status leads to future risk of hypertension. The BP-lowering efficacy of high-dose vitamin D supplementation for hypertension prevention must be tested in future randomized clinical trials.
Optimization-based transistor sizing (1988)

A combined heuristic and mathematical programming approach to transistor sizing is presented. A fast heuristic algorithm is used to obtain an initial sizing of the circuit and convert the transistor sizing problem into a nonlinear optimization problem. The problem is then solved, in spaces of reduced dimensionality, by mathematical programming techniques. To cope with the nondifferentiability of the circuit delays, the concept of generalized gradients is proposed to compute the delay sensitivities. Experiments justify the use of this sensitivity computation technique and show that the approach is a good compromise between the speed of the heuristic algorithm and the power of mathematical programming.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
AN IMPROVED METHOD FOR ISOLATION OF MOUSE PANCREATIC ISLETS (1985)

GOTOH, MITSUKAZU; MAKI, TAKASHI; KIYOIZUMI, TAKASHI; SATOMI, SUSUMU; MONACO, ANTHONY P. Author Information
ChemInform Abstract: Synthesis of 3‐(3‐Pyridyl)‐ and 3‐(3‐Benzo(b)thienyl)‐D‐alanine. (1987)

Abstract Coupling of the chloromethylhetarenes (I) with the acetaminomalonate (II), followed by partial saponification and decarboxylation, yields the racemic amino acid esters (IV).
The adaptation of bhk cells to a non‐ammoniagenic glutamate‐based culture medium (1999)

Although glutamine is a major carbon source for mammalian cells in culture, its chemical decomposition or cellular metabolism leads to an undesirable excess of ammonia. This limits the shelflife of glutamine-supplemented media and may reduce the cell yield under certain conditions. We have attempted to develop a less ammoniagenic medium for the growth of BHK-21 cells by a mole-to-mole substitution of glutamine by glutamate. This results in a medium that is thermally stable but unable to support an equivalent growth yield. However, supplementation of the glutamate-based medium with asparagine (3 mM) and a minimal level of glutamine (0.5 mM) restored the original growth capacity of the cultures. Substitution of the low level of glutamine with the glutamine dipeptides, ala-gln (1 mM), or gly-gln (3 mM) resulted in an equivalent cell yield and in a thermally stable medium. The ammonia accumulation in cultures with glutamate-based medium was reduced significantly (>60%). Factors mediating growth and adaptation in medium substituted with glutamate were also investigated. The maximum growth capacity of the BHK-21 cells in glutamate-based medium (without glutamine) was achieved after a period of adaptation of 5 culture passages from growth in glutamine-based cultures. Adaptation was not influenced by increases in glutamate uptake which was constitutively high in BHK cells. Adaptation was associated with changes in the activities of enzymes involved in glutamate or glutamine metabolism. The activities of glutamine synthetase (GS) and alanine aminotransferase (ALT) increased significantly and the activity of phosphate-activated glutaminase (PAG) decreased significantly. The activity of glutamate dehydrogenase (GDH) showed no significant change after adaptation to glutamate. These changes resulted in an altered metabolic profile which included a reduced ammonia production but an increased alanine production. Alanine production is suspected of being an alternative route for removal of excess nitrogen. © 1999 John Wiley & Sons, Inc. Biotechnol Bioeng 64: 298–309, 1999.
Rehabilitation After Amputation (2001)

The principles of amputee rehabilitation, from preamputation to reintegration into the work force and community, are reviewed. The authors discuss exercise techniques, training programs, and environmental modifications that have been found to be helpful in the rehabilitation of the amputee. The exercise programs presented here are divided into four main components: flexibility, muscle strength, cardiovascular training, and balance and gait. The programs include interventions by the physical, occupational, and recreational therapist under the supervision and guidance of a physician.
Pharmacokinetics of pantoprazole in man. (1996)

The proton pump inhibitor pantoprazole is a substituted benzimidazole sulphoxide for the treatment of acid-related gastrointestinal diseases such as reflux esophagitis, duodenal and gastric ulcers. Pantoprazole, administered as a 40 mg enteric coated tablet, is quantitatively absorbed. Its absolute bioavailability is 77% and does not change upon multiple dosing. Following a single oral dose of 40 mg, Cmax is approximately 2.5 mg/l, with a tmax of 2-3 h. The AUC(0,inf.) is approximately 5 mgxh/l. Pantoprazole shows linear pharmacokinetics after both i.v. and oral administration. Pantoprazole is extensively metabolized in the liver, has a total serum clearance of 0.1 l/h/kg, a serum elimination half-life of about 1.1 h, and an apparent volume of distribution of 0.15 l/kg. 98% of pantoprazole is bound to serum proteins. Elimination half-life, clearance and volume of distribution are independent of the dose. The main serum metabolite is formed by demethylation at the 4-position of the pyridine ring, followed by conjugation with sulphate. Almost 80% of an oral or intravenous dose is excreted as metabolites in urine; the remainder is found in feces and originates from biliary secretion. The pharmacokinetics of pantoprazole are unaltered in patients with renal failure. In patients with severe liver cirrhosis, the decreased rate of metabolism results in a half-life of 7-9 h. The clearance of pantoprazole is only slightly affected by age, its half-life being approximately 1.25 h in the elderly. Concomitant intake of food had no influence on the bioavailability of pantoprazole. Pantoprazole showed lack of cytochrome P450 interaction with concomitantly administered drugs in any of the studies conducted to date. Lack of interaction was also demonstrated with a coadministered antacid. The absence of inductive effects on metabolism after chronic administration was first shown by using antipyrine as a probe for mixed functional oxidative cytochrome P450 enzymes. Absence of CYP1A2 induction was confirmed using the specific probe caffeine. As sensitive probes for CYP3A enzyme induction, urinary excretion of D-glucaric acid and 6 beta-hydroxycortisol were also unchanged.
THE GENETICS OF CAENORHABDITIS ELEGANS (1974)

Methods are described for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm. About 300 EMS-induced mutants affecting behavior and morphology have been characterized and about one hundred genes have been defined. Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large.
A Longitudinal Study of Varicella-Zoster Virus Infections in Renal Transplant Recipients (1977)

A serum bank maintained for renal transplant recipients allowed for a longitudinal study of antibody responses before and after herpes zoster. Renal transplant recipients without herpes zoster served as controls. Antibody responses to varicella-zoster virus, herpes simplex virus type 1, and cytomegalovirus were measured. The serological responses following herpes zoster were prompt and sustained (in the majority of cases), transient, or not present at all. Zoster without an eruption occurred (apparent only on retrospective chart review) and furnished an explanation for unexplained unilateral pain syndromes in these patients. Asymptomatic rises in titer of antibody to varicella-zoster virus not explained by rises in antibody to herpes simplex virus occurred in both groups. This latter finding points to an unstable relation between virus and host and supports and hypothesis of Hope-Simpson that subclinical release of virus with resulting antigenic stimulation may maintain immunity to varicella-zoster virus. Patients with herpes zoster and controls did not differ in several humoral immune parameters that might have explained the occurrence of herpes zoster. There was no evidence that herpes zoster precipitated renal graft rejection.
Effect of a Fish Oil-Enriched Nutritional Supplement on Metabolic Mediators in Patients With Pancreatic Cancer Cachexia (2001)

Weight loss in advanced cancer patients is refractory to conventional nutritional support. This may be due to metabolic changes mediated by proinflammatory cytokines, hormones, and tumor-derived products. We previously showed that a nutritional supplement enriched with fish oil will reverse weight loss in patients with pancreatic cancer cachexia. The present study examines the effect of this supplement on a number of mediators thought to play a role in cancer cachexia. Twenty weight-losing patients with pancreatic cancer were asked to consume a nutritional supplement providing 600 kcal and 2 g of eicosapentaenoic acid per day. At baseline and after 3 wk, patients were weighed and samples were collected to measure serum concentrations of interleukin (IL)-6 and its soluble receptor tumor necrosis factor receptors I and II, cortisol, insulin, and leptin, peripheral blood mononuclear cell production of IL-1 beta, IL-6, and tumor necrosis factor, and urinary excretion of proteolysis inducing factor. After 3 wk of consumption of the fish oil-enriched nutritional supplement, there was a significant fall in production of IL-6 (from median 16.5 to 13.7 ng/ml, P = 0.015), a rise in serum insulin concentration (from 3.3 to 5.0 mU/l, P = 0.0064), a fall in the cortisol-to-insulin ratio (P = 0.0084), and a fall in the proportion of patients excreting proteolysis inducing factor (from 88% to 40%, P = 0.008). These changes occurred in association with weight gain (median 1 kg, P = 0.024). Various mediators of catabolism in cachexia are modulated by administration of a fish oil-enriched nutritional supplement in pancreatic cancer patients. This may account for the reversal of weight loss in patients consuming this supplement.
Reduced activity of plastid protoporphyrinogen oxidase causes attenuated photodynamic damage during high‐light compared to low‐light exposure (2006)

Summary Protoporphyrinogen oxidase (EC 1.3.3.4, PPOX) is the last enzyme in the branched tetrapyrrole biosynthetic pathway, before its substrate protoporphyrin is directed to the Mg and Fe branches for chlorophyll and haem biosynthesis, respectively. The enzyme exists in many plants in two similar isoforms, which are either exclusively located in plastids (PPOX I) or in mitochondria and plastids (PPOX II). Antisense RNA expression inhibited the formation of PPOX I in transgenic tobacco plants, which showed reduced growth rate and necrotic leaf damage. The cytotoxic effect is attributed to accumulation of photodynamically acting protoporphyrin. The expression levels of PPOX I mRNA and protein and the cellular enzyme activities were reduced to similar extents in transgenic plants grown under low‐ or high‐light conditions (70 and 530 μ mol photons m −2 sec −1 ). More necrotic leaf lesions were surprisingly generated under low‐ than under high‐light exposure. Several reasons were explored to explain this paradox and the intriguing necrotic phenotype of PPOX‐deficient plants under both light intensity growth conditions. The same reduction of PPOX expression and activity under both light conditions led to similar initial protoporphyrin, but to faster decrease in protoporphyrin content during high light. It is likely that a light intensity‐dependent degradation of reduced and oxidized porphyrins prevents severe photodynamic leaf damage. Moreover, under high‐light conditions, elevated contents of reduced and total low‐molecular‐weight antioxidants contribute to the protection against photosensitizing porphyrins. These reducing conditions stabilize protoporphyrinogen in plastids and allow their redirection into the metabolic pathway.
A pictorial query language for querying geographic databases using positional and OLAP operators (2002)

The authors propose a declarative Pictorial Query Language (called PQL) that is able to express queries on an Object-Oriented geographic database drawing the features which form the query. These features refer to the classic ones of a geographic environment (geo-null, geo-points, geo-polyline, and geo-region) and define the alphabet of the above mentioned language. This language, extended with respect to a previous one, considers twelve positional operators and a set of their specifications. Moreover, the possibility to use the mentioned language to query multidimensional databases is discussed. Finally, the characteristic of the mentioned language by a query example is shown.
Robust image based face recognition (2002)

In face recognition literature, 2D image based approaches are possibly the most promising ones. However, the 2D images/patterns can change dramatically in practice. We first study the performance degradation due to 2D distortions and illumination variations on the input images. We then propose several methods to improve the system performance. Finally experiments are carried out using FERET and other face databases to demonstrate the improvement of one particular system-the subspace LDA system.
Assessment tools in psoriatic arthritis. (2008)

A key objective of the assessment working group of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) was to identify, develop, evaluate, and validate outcome measures for use in clinical trials of psoriatic arthritis (PsA) and in clinical practice. In plenary and breakout sessions at the GRAPPA annual meeting (Boston, September 2007), the current status of measures used in clinical trials was reviewed, and development of simplified measures for use in various types of clinical practice (rheumatology, dermatology, and general practice) was discussed. We present a review of those discussions.
Initiating and Intensifying Insulin Therapy for Type 2 Diabetes: Why, When, and How (2009)

With the exception of insulin, all diabetes medications have limited glucose-lowering capacity. Therefore, as type 2 diabetes progresses, insulin is often needed to achieve near-normal glycemic targets and avoid complications. Concerns about the initiation of insulin by both clinicians and patients play a major role in poor glycemic control. This article discusses current guidelines for treating type 2 diabetes, exploring when and how insulin therapy should be initiated and intensified, and how barriers to insulin use may be overcome. Advances include the development of novel long-acting, premixed, and rapid-acting insulin analogues and delivery devices. These agents have near-physiological time-action profiles that allow safer, flexible, and more convenient dosing. Many patients find using an insulin pen device easier, more convenient, and more discreet than using a vial and syringe. Nurses and medical assistants can be trained to understand the glucose-lowering capacities and limitations of each class of diabetes medications, including recognizing when insulin therapy is necessary. In addition, by showing patients how easy insulin pens are to use, clinic staff can help empower, educate, and encourage patients with type 2 diabetes to optimize their glycemic control with insulin once oral antidiabetic agents alone have become inadequate.
연구 논문 : 아연 착화합물 입자형성에 미치는 금속염 및 다가알코올 첨가의 영향 (2012)

본 연구에서는 프린터 토너의 대전량 제어제로 사용되는 아연 착화합물 제조시 금속염과 다가알코올을 첨가함에 따라 변화되는 입자 형태와 평균 입도에 대해 고찰하였다. 아연 착화합물을 제조하기 위해 염화아연과 3,5-di-tert-butyl salicylic acid를 사용하였다. 다가알코올을 첨가함에 따른 입자형태 변화를 확인하기 위해 아연 착화합물 제조시 polyethylene glycol (PEG-300), glycerin 및 ethylene glycol을 첨가하였고, 금속염인 지르코늄 옥시클로라이드를 첨가함으로써 변화되는 입자크기를 확인하였다. 또한 금속염과 다가알코올을 동시에 첨가하여 입도변화를 확인한 결과, 각각 단독으로 첨가했을 때보다 아연 착화합물의 평균 입도가 더 많이 감소하는 것을 확인할 수 있었다. 특히, 지르코늄 착화합물의 함유량이 30 wt%이고 염화아연에 대한 PEG-300의 몰비를 3으로 하였을 때 아연 착화합물의 평균 입도가 1.84 μm로 순수한 아연 착화합물의 평균 입도(5.28 μm)의 34.9%로 가장 많이 감소한 것을 알 수 있었다.