gebhart/patrepeval huggingface dataset:
Increased EEG power and slowed dominant frequency in patients with neurogenic pain (2005)

To study the mechanisms of chronic neurogenic pain, we compared the power spectra of the resting EEG of patients (n = 15, 38-75 years, median 64 years, 6 women) and healthy controls (n = 15, 41-71 years, median 60 years, 8 women). On an average, the patient group exhibited higher spectral power over the frequency range of 2-25 Hz, and the dominant peak was shifted towards lower frequencies. Maximal differences appeared in the 7-9 Hz band in all electrodes. Frontal electrodes contributed most to this difference in the 13-15 Hz band. Bicoherence analysis suggests an enhanced coupling between theta (4-9 Hz) and beta (12-25 Hz) frequencies in patients. The subgroup of six patients free from centrally acting medication showed higher spectral power in the 2-18 Hz frequency range. On an individual basis, the combination of peak height and peak frequency discriminated between patient and control groups: discriminant analysis classified 87% of all subjects correctly. After a therapeutic lesion in the thalamus (central lateral thalamotomy, CLT) we carried out follow-up for a subgroup of seven patients. Median pain relief was 70 and 95% after 3 and 12 months, respectively. The average EEG power of all seven patients gradually decreased in the theta band and approached normal values only after 12 months. The excess theta EEG power in patients and its decrease after thalamic surgery suggests that both EEG and neurogenic pain are determined by tightly coupled thalamocortical loops. The small therapeutic CLT lesion is thought to initiate a progressive normalization in the affected thalamocortical system, which is reflected in both decrease of EEG power and pain relief.
Dutch translation and cross-cultural adaptation of the PROMIS® physical function item bank and cognitive pre-test in Dutch arthritis patients (2012)

Results suggest that the translated version of the PROMIS physical function item bank is semantically and conceptually equivalent to the original. Future work will be directed at creating a Dutch-Flemish final version of the item bank to be used in research with Dutch speaking populations.
Solution Properties (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolution PropertiesF. E. Bailey, George M. Powell, and Keith L. SmithCite this: Ind. Eng. Chem. 1958, 50, 1, 8–11Publication Date (Print):January 1, 1958Publication History Published online1 May 2002Published inissue 1 January 1958https://pubs.acs.org/doi/10.1021/ie50577a023https://doi.org/10.1021/ie50577a023research-articleACS PublicationsRequest reuse permissionsArticle Views192Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Bowel dysfunction in cystic fibrosis: Importance of breath testing (1998)

Bacterial overgrowth and carbohydrate malabsorption, particularly of sucrose, should be considered when assessing children with CF and abnormal stool patterns.
The Contribution of α2-Noradrenergic Mechanisms to Prefrontal Cortical Cognitive Function (1996)

This article aims to review research in nonhuman primates demonstrating that norepinephrine can enhance the cognitive functioning of the prefrontal cortex through actions at alpha 2 A-adrenergic receptors postjunctional to noradrenergic terminals. As prefrontal cortex cognitive deficits are prominent in several psychiatric disorders, including attention-deficit hyperactivity disorder, these basic findings may have relevance for the development of novel pharmacotherapies.
Genetic variation in porcine reproductive and respiratory syndrome virus isolates in the midwestern United States (1996)

The nucleotide sequence of a 3266 bp region encompassing open reading frames (ORFs) 2 through 7 of the porcine reproductive and respiratory syndrome virus (PRRSV) was determined for 10 isolates recovered from the midwestern United States. Pairwise comparisons showed that genetic distances between isolates ranged from 2.5% to 7.9% (mean 5.8% +/- 0.2%) whereas the Lelystad strain from Europe was, on average, 34.8% divergent from US clones. Thus, US and European PRRSV isolates represent genetically distinct clusters of the same virus. ORF 5, which encodes the envelope glycoprotein, was the most polymorphic [total nucleotide diversity (pi) = 0.097 +/- 0.007] and ORF 6, encoding the viral M protein, was the most conserved (pi = 0.038 +/- 0.003). The substantial differences in nucleotide diversity among ORFs suggests that the virus is evolving by processes other than simple accumulation of random neutral mutations. In support of this hypothesis, statistical analyses of the nucleotide sequence provided strong evidence for intragenic recombination or gene conversion in ORFs 2, 3, 4, 5 and 7, but not in ORF 6. An excess of synonymous (silent) substitutions was observed in all six ORFs, indicating an evolutionary pressure to conserve amino acid sequences. Taken together, the data indicate that despite intragenic recombination among extant PRRSV isolates, purifying selection has acted to maintain the primary structure of individual ORFs.
Use of pioglitazone in the treatment of diabetes: effect on cardiovascular risk (2013)

Pioglitazone and other thiazolidinediones (TZDs) initially showed great promise as unique receptor-mediated oral therapy for type 2 diabetes, but a host of serious side effects, primarily cardiovascular, have limited their utility. It is crucial at this point to perform a risk- benefit analysis to determine what role pioglitazone should play in our current treatment of type 2 diabetes and where the future of this class of drugs is headed. This review provides a comprehensive overview of the present literature. Clinical data currently available indicate that pioglitazone is an effective and generally well-tolerated treatment option for use in patients with type 2 diabetes. Pioglitazone can still reduce adverse cardiovascular risk.
Pattern Registration Between Spherical Block‐Copolymer Domains and Topographical Templates (2006)

Pattern registration is achieved in thin films of self-assembling block copolymers by using a topographical template to guide the positions of the polymer domains. The placement accuracy of the polymer domains is related to the edge roughness of the topographical template, and the ultimate placement accuracy is assessed (see Figure). For a block copolymer with spherical morphology, a registered polymer array is achieved by using a two-dimensional template.
Multi‐Perspective Modelling, Rendering and Imaging (2009)

Abstract A perspective image represents the spatial relationships of objects in a scene as they appear from a single viewpoint. In contrast, a multi‐perspective image combines what is seen from several viewpoints into a single image. Despite their incongruity of view, effective multi‐perspective images are able to preserve spatial coherence and can depict, within a single context, details of a scene that are simultaneously inaccessible from a single view, yet easily interpretable by a viewer. In computer vision, multi‐perspective images have been used for analysing structure revealed via motion and generating panoramic images with a wide field‐of‐view using mirrors. In this STAR, we provide a practical guide on topics in multi‐perspective modelling and rendering methods and multi‐perspective imaging systems. We start with a brief review of multi‐perspective image techniques frequently employed by artists such as the visual paradoxes of Escher, the Cubism of Picasso and Braque and multi‐perspective panoramas in cel animations. We then characterize existing multi‐perspective camera models, with an emphasis on their underlying geometry and image properties. We demonstrate how to use these camera models for creating specific multi‐perspective rendering effects. Furthermore, we show that many of these cameras satisfy the multi‐perspective stereo constraints and we demonstrate several multi‐perspective imaging systems for extracting 3D geometry for computer vision. The participants learn about topics in multi‐perspective modelling and rendering for generating compelling pictures for computer graphics and in multi‐perspective imaging for extracting 3D geometry for computer vision. We hope to provide enough fundamentals to satisfy the technical specialist without intimidating curious digital artists interested in multi‐perspective images. The intended audience includes digital artists, photographers and computer graphics and computer vision researchers using or building multi‐perspective cameras. They will learn about multi‐perspective modelling and rendering, along with many real world multi‐perspective imaging systems.
Embryonic Stem Cell Research (2002)

To the Editor —

I see that the American Academy of Pediatrics (AAP) has endorsed the destruction of human embryos for stem cell research. 1 Although the second paragraph of the position statement from the Committee on Pediatric Research and the Committee on Bioethics contains a brief but well-written summary of the objections of those who oppose embryonic stem cell research, these objections are not answered but merely ignored in the rest of the statement. But even if you accept human embryonic stem cell research, the statement is inconsistent.

The statement says, “The use of embryos may require special considerations to limit the research to important issues that cannot be addressed in other ways … ” 1(p813) What about research on stem cells from sources that do not require the killing of the donor such as umbilical cords/placentas and adult sources such as skin, fat, and bone marrow? Has research on these sources progressed to the point where we can say they are unable to provide treatments for “spinal cord and bone injuries, diabetes, primary or acquired immunodeficiencies, cancer, metabolic and genetic disorders, and a variety of birth defects … toxicities of drug treatment and environmental pollutants … fetal alcohol syndrome?” 1(p814) Not from the reports that I have read. We are nowhere near the limit of the benefits available from research on stem cells from nonethically controversial sources, and we cannot say that they cannot provide the above benefits. Although certain issues involving development and teratogenesis could be better studied using the whole embryo rather than cell lines of either embryonic or postnatal sources, I do not see how this can be studied without going beyond the 14-day limit that the …
Identification of Major Histocompatibility Complex Class II-Restricted Antigens and Epitopes of the Epstein-Barr Virus by a Novel Bacterial Expression Cloning Approach (2006)

Epstein-Barr virus (EBV)-specific T cells have been successfully used to treat or prevent EBV-positive lymphoproliferative disease in hematopoietic stem cell transplant recipients, but the antigens recognized by the infused CD4+ T cells have remained unknown. Here, we describe a simple procedure that permits the identification of viral T-helper (TH)-cell antigens and epitopes. This direct antigen identification method is based on the random expression of viral polypeptides fused to chloramphenicol acetyltransferase (CAT) in bacteria, which are subsequently fed to major histocompatibility complex class II+ antigen-presenting cells and probed with antigen-specific T cells. The fusion of antigenic fragments to CAT offers several advantages. First, chloramphenicol treatment allows the selection of bacteria expressing antigen-CAT fusion proteins in frame, which greatly reduces the number of colonies to be screened. Second, antigenic fragments fused to CAT are expressed at high levels, even when derived from proteins that are toxic to bacteria. Third, the uniformly high expression level of antigen-CAT fusion proteins permits the establishment of large and representative pool sizes. Finally, antigen identification does not require knowledge of the restriction element and often leads directly to the identification of the T-cell epitope. Using this approach, the BALF4 and BNRF1 proteins were identified as targets of the EBV-specific T-helper-cell response, demonstrating that lytic cycle antigens are a relevant component of the EBV-specific TH-cell response.
Prediction of Long-Term Exposure to Indoor Air Pollutants Using Short-Term Measurements (1989)

The Canadian federal and provincial health ministers released a document in 1987 entitled “Exposure Guidelines for Residential Indoor Air Quality.” These guidelines establish the maximum recommended concentrations of nine pollutants (or pollutant groups) and a range of relative humidities, often with short-term and long-term levels separately identified. No simple measurement can determine whether a residence does and will continue to meet the guidelines. An analysis protocol is needed to predict concentration peaks and averages under conditions that are different from those that occurred during the test. To perform these analyses, many measurements and observations other than the simple point-in-time concentrations must be made. They include: instantaneous air change rates, taken at the same time and point as the pollutant concentrations; envelope leakage and effective ventilation areas; the weather during the test; and a definition of the exposure classification of the residence. This paper develops the logic for, and presents, a proposed protocol and subsidiary measurements and observations that could serve as a first attempt at meeting the needs of such a prediction technique. It is based on the single-cell model of Wadden and Scheff, plus the averaging techniques of Yuill, in addition to a few concepts developed by the author. Research needs include a better definition of non-ventilation removal mechanisms and source variability, as well as verification that the method adequately predicts both long-term average concentrations and critical short-term peaks.
Fatty acid composition of erythrocyte, platelet, and serum lipids in strict vegans (1995)

The fatty acid composition of erythrocytes, platelets, and serum lipids was compared between subjects who had been eating a strict uncooked vegan diet ("living food") for years and omnivore controls. The vegan diet contains equal amounts of fat but more monounsaturated and polyunsaturated and less saturated fatty acids than the mixed diet of the control group. In vegans, the proportion of linoleic acid was greater in all lipid fractions studied. Also, the levels of other n-6 fatty acids were greater, with the exception of arachidonic acid levels, which were similar in most fractions. In erythrocytes, platelets and serum phospholipid fractions, this increase was mainly at the expense of the n-3 fatty acids. The proportions of eicosapentaenoic and docosahexaenoic acid were only 29-36% and 49-52% of those in controls, respectively. In vegans the ratio of n-3 to n-6 fatty acids was only about half that in omnivores. In addition to the lower levels of n-3 fatty acids, the proportions of palmitic and stearic acids were lower in serum cholesteryl esters, triglycerides and free fatty acids of vegans. The proportion of oleic acid was slightly lower only in serum cholesteryl esters and erythrocyte phosphatidylserine. The results show that, in the long term, the vegan diet has little effect on the proportions of oleic and arachidonic acids, whereas the levels of n-3 fatty acids are depressed to very low levels with prolonged consumption of the high linoleic and oleic acid components of this diet.
Chapter 12 Methods for Myoblast Transplantation (1997)

This chapter focuses on the techniques of transplanting myoblasts derived from primary cultures of mouse muscle. Myoblast transplantation provides a unique means to effect in vivo gene transfer because of the ability of implanted myoblasts to fuse with host myofibers. Among the limitations to more widespread use of myoblast transplantation is the time required for growth, purification, and labeling of cells and for detailed transplant analysis. For most applications of myoblast transplantation, it is essential to have a method of differentiating the donor cells from the host cells, whether to determine the fate of the transplanted cells, to assess the effect on host fibers of the incorporation of donor cells, or simply to assess the efficiency of the transplantation procedure. Retroviral-mediated gene transfer offers a rapid and efficient method of introducing a hereditable marker into dividing cells.
Access ordering and memory-conscious cache utilization (2002)

As processor speeds increase relative to memory speeds, memory bandwidth is rapidly becoming the limiting performance, factor for many applications. Several approaches to bridging this performance gap have been suggested. This paper examines one approach, access ordering, and pushes its limits to determine bounds on memory performance. We present several access-ordering schemes, and compare their performance, developing analytic models and partially validating these with benchmark timings on the Intel i860XR.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Formulation, characterization, and expression of a recombinant MOMP Chlamydia trachomatis DNA vaccine encapsulated in chitosan nanoparticles (2013)

Chlamydia trachomatis is a bacterial sexually transmitted infection affecting millions of people worldwide. Previous vaccination attempts have employed the recombinant major outer membrane protein (MOMP) of C. trachomatis nonetheless, with limited success, perhaps, due to stability, degradation, and delivery issues. In this study we cloned C. trachomatis recombinant MOMP DNA (DMOMP) and encapsulated it in chitosan nanoparticles (DMCNP) using the complex coacervation technique. Physiochemical characterizations of DMCNP included transmission and scanning electron microcopy, Fourier transform infrared and ultraviolet-visible spectroscopy, and zeta potential. Encapsulated DMOMP was 167-250 nm, with a uniform spherical shape and homogenous morphology, and an encapsulation efficiency > 90%. A slow release pattern of encapsulated DMOMP, especially in acidic solution, was observed over 7 days. The zeta potential of DMCNP was ~8.80 mV, which indicated that it was highly stable. Toxicity studies of DMCNP (25-400 μg/mL) to Cos-7 cells using the MTT assay revealed minimal toxicity over 24-72 hours with >90% viable cells. Ultra-violet visible (UV-vis) spectra indicated encapsulated DMOMP protection by chitosan, whereas agarose gel electrophoresis verified its protection from enzymatic degradation. Expression of MOMP protein in DMCNP-transfected Cos-7 cells was demonstrated via Western blotting and immunofluorescence microscopy. Significantly, intramuscular injection of BALB/c mice with DMCNP confirmed the delivery of encapsulated DMOMP, and expression of the MOMP gene transcript in thigh muscles and spleens. Our data show that encapsulation of DMOMP in biodegradable chitosan nanoparticles imparts stability and protection from enzymatic digestion, and enhances delivery and expression of DMOMP in vitro and in mice. Further investigations of the nanoencapsulated DMCNP vaccine formulation against C. trachomatis in mice are warranted.
Helicobacter infection decreases reproductive performance of IL10-deficient mice. (2008)

Infections with a variety of Helicobacter species have been documented in rodent research facilities, with variable effects on rodent health. Helicobacter typhlonius has been reported to cause enteric disease in immunodeficient and IL10(-/-) mice, whereas H. rodentium has only been reported to cause disease in immunodeficient mice coinfected with other Helicobacter species. The effect of Helicobacter infections on murine reproduction has not been well studied. The reproductive performance of C57BL/6 IL10(-/-) female mice intentionally infected with H. typhlonius, H. rodentium, or both was compared with that of age-matched uninfected controls or similarly infected mice that received antihelicobacter therapy. The presence of Helicobacter organisms in stool and relevant tissues was detected by PCR assays. Helicobacter infection of IL10(-/-) female mice markedly decreased pregnancy rates and pup survival. The number of pups surviving to weaning was greatest in noninfected mice and decreased for H. rodentium > H. typhlonius >> H. rodentium and H. typhlonius coinfected mice. Helicobacter organisms were detected by semiquantitative real-time PCR in the reproductive organs of a subset of infected mice. Treatment of infected mice with a 4-drug regimen consisting of amoxicillin, clarithromycin, metronidazole, and omeprazole increased pregnancy rates, and pup survival and dam fecundity improved. We conclude that infection with H. typhlonius, H. rodentium, or both decreased the reproductive performance of IL10(-/-) mice. In addition, antihelicobacter therapy improved fecundity and enhanced pup survival.
Kinetics of swelling and shrinking of gels (1990)

The kinetics of swelling and shrinking of gels is theoretically generalized and experimentally studied. A new relation, in addition to the differential equation developed by Tanaka and Fillmore, is formulated to solve the kinetics of gels having arbitrary shape. Using our new theory, we provide explicit solutions for long cylinder and large disk gels. These solutions predict that the effective diffusion constants of long cylinder and large disk gels are 1.5 and 3 times smaller than that of a spherical gel. The relaxation times of long cylinder and large disk gels with small shear modulus μ are approximately 2.0 and 5.7 times longer than that of a sphere, where the diameters of the cylinder and the sphere and the thickness of the disk are the same. The theory also concludes that the experimentally measured kinetics of a long cylinder and disk gels along the z axis and the radial axis are the same. The results have been excellently confirmed by the experiments.