gebhart/patrepeval huggingface dataset:
Suppression of Melanoma-Associated Neoangiogenesis by Bevacizumab (2008)

Intraocular administration of the anti-VEGF drug bevacizumab causes immediate and complete regression of melanoma-associated angiogenesis. The rationale for the therapeutic strategy in our patient was an elevated level of VEGF in the vitreous cavity. Because we could not demonstrate a direct antiproliferative effect of bevacizumab on melanoma metastasis, bevacizumab seems most promising if evaluated in combination with antiproliferative agents.
Mechanism of Development of Pigment Value in Zinc Sulfide (1933)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism of Development of Pigment Value in Zinc SulfideLincoln T. Work and I. Herbert OdellCite this: Ind. Eng. Chem. 1933, 25, 5, 543–549Publication Date (Print):May 1, 1933Publication History Published online1 May 2002Published inissue 1 May 1933https://pubs.acs.org/doi/10.1021/ie50281a019https://doi.org/10.1021/ie50281a019research-articleACS PublicationsRequest reuse permissionsArticle Views44Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Prevalence of Age-Related Maculopathy in Older Europeans (2006)

Age-specific prevalences of age-related maculopathy in the European Eye Study (EUREYE) are similar to other population-based studies in Western populations.
Nitrogenase promoter-lacZ fusion studies of essential nitrogen fixation genes in Bradyrhizobium japonicum I110 (1986)

DNA fragments containing either the nifD or nifH promoter and 5' structural gene sequences from Bradyrhizobium japonicum I110 were fused in frame to the lacZ gene. Stable integration of these nif promoter-lacZ fusions by homologous double reciprocal crossover into a symbiotically nonessential region of the B. japonicum chromosome provided an easy assay for the effects of potential nif regulatory mutants. The level of beta-galactosidase activity expressed from these two nif promoter-lacZ fusions was assayed in bacteroids of B. japonicum I110 wild type and Fix mutants generated by transposon Tn5 mutagenesis and identified in the accompanying paper. No nif-positive regulatory mutants were identified from among an array of Fix- mutants in which Tn5 was inserted 9 kilobase pairs upstream of the nifDK operon and within the 18-kilobase-pair region separating the nifDK and nifH operons. This result indicates that there are no genes in these regions involved in the regulation of nitrogenase structural gene expression. Interestingly, the level of beta-galactosidase activity expressed from the nifH promoter was twice that expressed from the nifD promoter, suggesting that the normal cellular level of the nifH gene product in bacteroids is in a 2:1 ratio with the nifD gene product instead of in the 1:1 stoichiometry of the nitrogenase enzyme complex.
The rational design and construction of a cuboidal iron–sulfur protein (1997)

Rational protein design is an emerging approach for testing general theories of protein chemistry through the creation of new structures and functions. Here we present the first successful introduction by rational design of a [Fe4S4] cuboidal cluster into the hydrophobic core of Escherichia coli thioredoxin, a protein normally devoid of metal centers. Cuboidal [Fe4S4] is one of the stable forms of self-assembled iron-sulfur clusters that are thought to represent some of the earliest evolved biological redox centers. [Fe4S4] clusters have been recruited for use in a variety of proteins whose functions are central to many of the major biochemical processes ranging from simple soluble electron-transfer agents, to membrane-bound components of electron-transfer chains, to electron reservoirs in complex metalloenzymes such as nitrogenase. By situating an [Fe4S4] cluster into a protein environment not previously adapted by evolution we can explore the factors by which their activity is modulated by the protein matrix.
Methane oxidation at room temperature and atmospheric pressure activated by light via polytungstate dispersed on titania (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMethane oxidation at room temperature and atmospheric pressure activated by light via polytungstate dispersed on titaniaM. Graetzel, K. R. Thampi, and J. KiwiCite this: J. Phys. Chem. 1989, 93, 10, 4128–4132Publication Date (Print):May 1, 1989Publication History Published online1 May 2002Published inissue 1 May 1989https://pubs.acs.org/doi/10.1021/j100347a050https://doi.org/10.1021/j100347a050research-articleACS PublicationsRequest reuse permissionsArticle Views445Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Developing Defined Culture Systems for Human Pluripotent Stem Cells (2011)

Human pluripotent stem cells hold promising potential in many therapeutics applications including regenerative medicine and drug discovery. Over the past three decades, embryonic stem cell research has illustrated that embryonic stem cells possess two important and distinct properties: the ability to continuously self-renew and the ability to differentiate into all specialized cell types. In this article, we will discuss the continuing evolution of human pluripotent stem cell culture by examining requirements needed for the maintenance of self-renewal in vitro. We will also elaborate on the future direction of the field toward generating a robust and completely defined culture system, which has brought forth collaborations amongst biologists and engineers. As human pluripotent stem cell research progresses towards identifying solutions for debilitating diseases, it will be critical to establish a defined, reproducible and scalable culture system to meet the requirements of these clinical applications.
Effect of Pexelizumab, an Anti-C5 Complement Antibody, as Adjunctive Therapy to Fibrinolysis in Acute Myocardial Infarction (2003)

When used adjunctively with fibrinolysis, pexelizumab blocked complement activity but reduced neither infarct size by creatine kinase-MB assessment nor adverse clinical outcomes.
A Disease Resistance Gene in Arabidopsis with Specificity for Two Different Pathogen Avirulence Genes (1994)

Sherryl R. Bisgrove, Michael T. Simonich, Nadine M. Smith, Airlie Sattler, Roger W. Innes, A Disease Resistance Gene in Arabidopsis with Specificity for Two Different Pathogen Avirulence Genes, The Plant Cell, Vol. 6, No. 7 (Jul., 1994), pp. 927-933
Strategy and Choice (1991)

From the coalition's desert showdown with Saddam Hussein to the dieter's duel with himself in the midnight kitchen, strategic choices determine destinies. These essays by wellknown scholars - economists, psychologists, philosophers, and political scientists, inspired by master strategist Thomas Schelling - present the most significant recent advances in strategic choice theory. In activities ranging from gift giving to political wheeling and dealing, men and women strive ingeniously - though sometimes counterproductively - to secure desired outcomes. But as this book makes clear' the fundamental questions for strategy continually reappear: What factors motivate individuals' values and actions? What principles guide effective bargaining? How can incentives and decision processes be structured to yield desirable collective outcomes? In three parts, the book addresses many-player, fewplayer, and one-player situations. The first takes up questions such as: What outcomes result when an individual's welfare depends on comparisons with the situation of others? Under what circumstances do we expect many-player outcomes to at least resemble participants' desired outcomes? The second asks how we can build trust, distinguish between gifts and bribes, make commitments credible, or employ third parties to improve our bargaining position. The final part of the book focuses on the struggle of the individual decision maker. How does the recollected past influence one's evaluation of the present? How can we cope with errors in decision making? When should we rely on rules and principles, as opposed to the careful weighing of alternatives prescribed by the theory of rational choice? And - the most ethically challenging question - how shall we value human life?
The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species (2001)

Cytoplasmic protein-tyrosine kinases (PTKs) are enzymes involved in transducing a vast number of signals in metazoans. The importance of the Tec family of kinases was immediately recognized when, in 1993, mutations in the gene encoding Bruton's tyrosine kinase (Btk) were reported to cause the human disease X-linked agammaglobulinemia (XLA). Since then, additional kinases belonging to this family have been isolated, and the availability of full genome sequences allows identification of all members in selected species enabling phylogenetic considerations. Tec kinases are endowed with Pleckstrin homology (PH) and Tec homology (TH) domains and are involved in diverse biological processes related to the control of survival and differentiation fate. Membrane translocation resulting in the activation of Tec kinases with subsequent Ca2+ release seems to be a general feature. However, nuclear translocation may also be of importance. The purpose of this essay is to characterize members of the Tec family and discuss their involvement in signaling. The three-dimensional structure, expression pattern and evolutionary aspects will also be considered.
Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers (1987)

Fibroblast colonies (clones) were obtained by explantation of bone marrow single-cell suspensions and were used to establish multicolony and single-colony derived fibroblast cultures by successive passaging of either pooled or individual colonies. When transplanted in diffusion chambers after 20-30 cell doublings in vitro, the descendants of fibroblast colony-forming cells (FCFC), whether grown from single or pooled colonies, retained the ability for bone and cartilage formation. The content of osteogenic precursors in the cultured progeny significantly outnumbered the initiating FCFC. Thus the high proliferative potential of bone marrow FCFC and their ability to serve as common precursors of bone and cartilage-forming cells makes them probable candidates for the role of osteogenic stem cells.
Anticonvulsant drug antagonism of delta9tetrahydrocannabinol-induced seizures in rabbits. (1977)

A population of New Zealand White rabbits exhibit behavioral convulsions when given low doses of psychoactive cannabinoids of marijuana. Carbamazepine, diazepam and phenytoin were most effective in blocking these convulsions caused by delta9tetrahydrocannabinol (delta9THC). Phenobarbital and ethosuximide also blocked convulsions but only at toxic doses. Cannabidiol was effective in blocking convulsions when given concurrently with, but not prior to delta9THC.
Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer (2012)

The inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the intestine. The prevalence in the United States is greater than 200 cases per 100,000, with the total number of IBD patients between 1 and 1.5 million. CD may affect all parts of the gastrointestinal tract, from mouth to anus, but most commonly involves the distal part of the small intestine or ileum, and colon. UC results in colonic inflammation that can affect the rectum only, or can progress proximally to involve part of or the entire colon. Clinical symptoms include diarrhea, abdominal pain, gastrointestinal bleeding, and weight loss. A serious long-term complication of chronic inflammation is the development of colorectal cancer. A genetic basis for IBD had long been recognized based on the increased familial risk. However, significant discordance for CD in twins, and a much less robust phenotypic concordance for UC, suggested additional factors play a role in disease pathogenesis, including environmental factors. In the past several years, progress in understanding the molecular basis of IBD has accelerated, beginning with the generation of animal models of colitis and progressing to the identification of specific genetic markers from candidate gene, gene linkage, and genome-wide association analyses. Genetic studies have also resulted in the recognition of the importance of environmental factors, particularly the crucial role of the gut microbiota in CD and UC. Altered immune responses to the normal intestinal flora are key factors in IBD pathogenesis. In this research topic, the genetic basis of IBD, the genetic and cellular alterations associated with colitis-associated colon cancer, and the emerging role of the intestinal microbiota and other environmental factors will be reviewed.
Protein-tyrosine Kinase Activation Is Required for Lipopolysaccharide Induction of Interleukin 1β and NFκB Activation, but Not NFκB Nuclear Translocation (1996)

In human monocytes, interleukin 1beta protein production and steady state mRNA levels are increased in response to lipopolysaccharide, predominantly as a result of increased transcription of the interleukin 1beta gene. Expression of interleukin 1beta and other cytokines, such as interleukin 6 and tumor necrosis factor alpha, has been shown to be dependent on the activation of the transcription factor, NFkappaB. Since recent studies have shown that lipopolysaccharide-induced tyrosine kinase activation is not required for NFkappaB nuclear translocation, we sought to determine whether NFkappaB translocated in the absence of tyrosine kinase activity was active in stimulating transcription. We have found that, in the human pro-monocytic cell line, THP-1, the lipopolysaccharide-induced expression of interleukin 1beta is dependent on tyrosine kinase activation. Tyrosine kinases are not required for lipopolysaccharide-mediated nuclear translocation of NFkappaB. However, in the absence of tyrosine kinase activity, the ability of NFkappaB to stimulate transcription is impaired. This inhibition of transcription is specific for NFkappaB; in the absence of tyrosine kinase activity, AP-1-dependent transcription is enhanced. These results suggest that, while lipopolysaccharide-induced expression of inflammatory mediators requires tyrosine kinase activity, tyrosine kinase activity is not obligatory for lipopolysaccharide signal transduction.
Methanogenic bacteria in human vaginal samples (1990)

Twelve vaginal samples were collected from separate patients, processed anaerobically, and added to methanogenic enrichment medium. Methanogenic activity was detected in two samples, both of which were from patients with bacterial vaginosis. None of the samples from healthy patients yielded positive methanogen cultures. One sample from a patient with bacterial vaginosis did not show any detectable methanogenic activity. Two methanogen isolates were obtained from one of the methanogen-positive samples, and both were identified as Methanobrevibacter smithii on the basis of morphological, cultural, and immunological features.
The lower boundary of the hydrogen concentration required for enhancing oxygen diffusion and thermal donor formation in Czochralski silicon (2005)

Hydrogen-enhanced thermal donor formation is achieved in p-type Czochralski silicon after exposure to hydrogen plasma and posthydrogenation annealing. Hydrogen diffusivities for the temperatures between 350 and 450 °C are determined based on spreading resistance probe measurement. The hydrogen diffusion is found to be trap limited. Two relationships (for different temperature ranges) are established to describe the lower boundary of the hydrogen concentration required for enhancing oxygen diffusion and thermal donor formation in silicon. The result reveals that hydrogen atoms both in free and in trapped states can enhance the oxygen diffusion.
Flexible, wide-area storage for distributed systems with WheelFS (2009)

WheelFS is a wide-area distributed storage system intended to help multi-site applications share data and gain fault tolerance. WheelFS takes the form of a distributed file system with a familiar POSIXinterface. Its design allows applications to adjust the tradeoff between prompt visibility of updates from other sites and the ability for sites to operate independently despite failures and long delays. WheelFS allows these adjustments via semantic cues, which provide application control over consistency, failure handling, and file and replica placement. WheelFS is implemented as a user-level file system and is deployed on PlanetLab and Emulab. Three applications (a distributed Web cache, an email service and large file distribution) demonstrate that WheelFS’s file system interface simplifies construction of distributed applications by allowing reuse of existing software. These applications would perform poorly with the strict semantics implied by a traditional file system interface, but by providing cues to WheelFS they are able to achieve good performance. Measurements show that applications built on WheelFS deliver comparable performance to services such as CoralCDN and BitTorrent that use specialized wide-area storage systems. 1
Analyzing Market-Based Resource Allocation Strategies for the Computational Grid (2001)

In this paper, the authors investigate G-commerce—computational economies for controlling resource allocation in computational Grid settings. They define hypothetical resource consumers (representing users and Grid-aware applications) and resource producers (representing resource owners who “sell” their resources to the Grid). The authors then measure the efficiency of resource allocation under two different market conditions—commodities markets and auctions—and compare both market strategies in terms of price stability, market equilibrium, consumer efficiency, and producer efficiency. The results indicate that commodities markets are a better choice for controlling Grid resources than previously defined auction strategies.
Simultaneous Measurements of Glucose, Glutamine, Ammonia, Lactate, and Glutamate in Aqueous Solutions by Near-Infrared Spectroscopy (1996)

Calibration models are generated and evaluated for the measurement of five different components in synthetic mixtures prepared in aqueous solutions. Mixtures of glucose, glutamine, ammonia, lactate, and glutamate were prepared to simulate concentration levels expected during routine bioreactor fermentation processes. Near-IR spectra were collected from these solutions over the spectral range from 5000 to 4000 cm −1 . This spectral information was used to build individual multivariate calibration models for each analyte. Models were constructed on the basis of partial least-squares regression of raw and Fourier filtered absorbance spectra. Each analyte could be detected selectively with mean percent errors of prediction ranging from 4 to 8%.
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes (1995)

We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte differentiation. Acrp30 is structurally similar to complement factor C1q and to a hibernation-specific protein isolated from the plasma of Siberian chipmunks; it forms large homo-oligomers that undergo a series of post-translational modifications. Like adipsin, secretion of Acrp30 is enhanced by insulin, and Acrp30 is an abundant serum protein. Acrp30 may be a factor that participates in the delicately balanced system of energy homeostasis involving food intake and carbohydrate and lipid catabolism. Our experiments also further corroborate the existence of an insulin-regulated secretory pathway in adipocytes.
Use of Adeno-Associated Virus Vector for Cardiac Gene Delivery in Large-Animal Surgical Models of Heart Failure (2017)

The advancement of gene therapy-based approaches to treat heart disease represents a need for clinically relevant animal models with characteristics equivalent to human pathologies. Rodent models of cardiac disease do not precisely reproduce heart failure phenotype and molecular defects. This has motivated researchers to use large animals whose heart size and physiological processes more similar and comparable to those of humans. Today, adeno-associated viruses (AAV)-based vectors are undoubtedly among the most promising DNA delivery vehicles. Here, AAV biology and technology are reviewed and discussed in the context of their use and efficacy for cardiac gene delivery in large-animal models of heart failure, using different surgical approaches. The remaining challenges and opportunities for the use of AAV-based vector delivery for gene therapy applications in the clinic are also highlighted.
Effects of low-power light therapy on wound healing: LASER x LED (2014)

Several studies demonstrate the benefits of low-power light therapy on wound healing. However, the use of LED as a therapeutic resource remains controversial. There are questions regarding the equality or not of biological effects promoted by LED and LASER. One objective of this review was to determine the biological effects that support the use of LED on wound healing. Another objective was to identify LED´s parameters for the treatment of wounds. The biological effects and parameters of LED will be compared to those of LASER. Literature was obtained from online databases such as Medline, PubMed, Science Direct and Scielo. The search was restricted to studies published in English and Portuguese from 1992 to 2012. Sixty-eight studies in vitro and in animals were analyzed. LED and LASER promote similar biological effects, such as decrease of inflammatory cells, increased fibroblast proliferation, stimulation of angiogenesis, granulation tissue formation and increased synthesis of collagen. The irradiation parameters are also similar between LED and LASER. The biological effects are dependent on irradiation parameters, mainly wavelength and dose. This review elucidates the importance of defining parameters for the use of light devices.