gebhart/patrepeval huggingface dataset:
Expression of prostate-specific antigen (PSA) correlates with poor response to tamoxifen therapy in recurrent breast cancer (1999)

Prostate-specific antigen (PSA) is a serine protease which may play a role in a variety of cancer types, including breast cancer. In the present study, we evaluated whether the level of PSA in breast tumour cytosol could be associated with prognosis in primary breast cancer, or with response to tamoxifen therapy in recurrent disease. PSA levels were determined by enzyme-linked immunosorbent assay (ELISA) in breast tumour cytosols, and were correlated with prognosis in 1516 patients with primary breast cancer and with response to first-line tamoxifen therapy in 434 patients with recurrent disease. Relating the levels of PSA with classical prognostic factors, low levels were more often found in larger tumours, tumours of older and post-menopausal patients, and in steroid hormone receptor-negative tumours. There was no significant association between the levels of PSA with grade of differentiation or the number of involved lymph nodes. In patients with primary breast cancer, PSA was not significantly related to the rate of relapse, and a positive association of PSA with an improved survival could be attributed to its relationship to age. In patients with recurrent breast cancer, a high level of PSA was significantly related to a poor response to tamoxifen therapy, and a short progression-free and overall survival after start of treatment for recurrent disease. In Cox multivariate analyses for response to therapy and for (progression-free) survival, corrected for age/menopausal status, disease-free interval, site of relapse and steroid hormone receptor status, PSA was an independent variable of poor prognosis. It is concluded that the level of PSA in cytosols of primary breast tumours might be a marker to select breast cancer patients who may benefit from systemic tamoxifen therapy.
Photoconductivity in CdSe quantum dot solids (2000)

We report measurements of photoconductivity and electric field induced photoluminescence quenching in three-dimensional close-packed solids of colloidal CdSe quantum dots. Our measurements suggest that photoexcited, quantum confined excitons are ionized by the applied electric field with a rate that depends on both the size and surface passivation of the quantum dots. Separation of electron-hole pairs confined to the core of the quantum dot requires significantly more energy than separation of carriers trapped at the surface and occurs through tunneling processes. We present a simple resonant tunneling model for the initial charge separation step that qualitatively reproduces both the size and surface dependence of the photoconductivity as a function of applied field. We show that the charge generation efficiency increases with increasing temperature as nonradiative and radiative recombination pathways increasingly compete with charge separation.
Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study. (1999)

We evaluated 18,014 patients who underwent allogeneic bone marrow transplantation (BMT) at 235 centers worldwide to examine the incidence of and risk factors for posttransplant lymphoproliferative disorders (PTLD). PTLD developed in 78 recipients, with 64 cases occurring less than 1 year after transplantation. The cumulative incidence of PTLD was 1.0% +/- 0.3% at 10 years. Incidence was highest 1 to 5 months posttransplant (120 cases/10,000 patients/yr) followed by a steep decline to less than 5/10,000/yr among >/=1-year survivors. In multivariate analyses, risk of early-onset PTLD (<1 year) was strongly associated (P <.0001) with unrelated or human leukocyte antigen (HLA) mismatched related donor (relative risk [RR] = 4.1), T-cell depletion of donor marrow (RR = 12.7), and use of antithymocyte globulin (RR = 6.4) or anti-CD3 monoclonal antibody (RR = 43.2) for prophylaxis or treatment of acute graft-versus-host disease (GVHD). There was a weaker association with the occurrence of acute GVHD grades II to IV (RR = 1.9, P =.02) and with conditioning regimens that included radiation (RR = 2.9, P =.02). Methods of T-cell depletion that selectively targeted T cells or T plus natural killer (NK) cells were associated with markedly higher risks of PTLD than methods that removed both T and B cells, such as the CAMPATH-1 monoclonal antibody or elutriation (P =.009). The only risk factor identified for late-onset PTLD was extensive chronic GVHD (RR = 4.0, P =.01). Rates of PTLD among patients with 2 or >/=3 major risk factors were 8.0% +/- 2.9% and 22% +/- 17.9%, respectively. We conclude that factors associated with altered immunity and T-cell regulatory mechanisms are predictors of both early- and late-onset PTLD.
Quality: quantification improvement by converting lineshapes to the lorentzian type (1990)

A method of time domain deconvolution, QUALITY, is described for general use in quantitative NMR spectroscopy. By division of the experimental NMR time domain signal by a reference signal, which may be obtained either in a separate experiment or via inverse Fourier transformation of an isolated single resonance in the experimental spectrum, perfect Lorentzian lineshapes can be obtained regardless of the magnetic field inhomogeneity. Experiments, both in vivo using a surface coil and in vitro using a surface coil and a HR NMR probe, show excellent performance of the method.
Optimizing data aggregation for cluster-based internet services (2003)

Large-scale cluster-based Internet services often host partitioned datasets to provide incremental scalability. The aggregation of results produced from multiple partitions is a fundamental building block for the delivery of these services. This paper presents the design and implementation of a programming primitive -- Data Aggregation Call (DAC) -- to exploit partition parallelism for cluster-based Internet services. A DAC request specifies a local processing operator and a global reduction operator, and it aggregates the local processing results from participating nodes through the global reduction operator. Applications may allow a DAC request to return partial aggregation results as a tradeoff between quality and availability. Our architecture design aims at improving interactive responses with sustained throughput for typical cluster environments where platform heterogeneity and software/hardware failures are common. At the cluster level, our load-adaptive reduction tree construction algorithm balances processing and aggregation load across servers while exploiting partition parallelism. Inside each node, we employ an event-driven thread pool design that prevents slow nodes from adversely affecting system throughput under highly concurrent workload. We further devise a staged timeout scheme that eagerly prunes slow or unresponsive servers from the reduction tree to meet soft deadlines. We have used the DAC primitive to implement several applications: a search engine document retriever, a parallel protein sequence matcher, and an online parallel facial recognizer. Our experimental and simulation results validate the effectiveness of the proposed optimization techniques for reducing response time, improving throughput, and gracefully handling server unresponsiveness. We also demonstrate the ease-of use of the DAC primitive and the scalability of our architecture design.
Quality characteristics of West African shea butter (Vitellaria paradoxa) and approaches to extend shelf-life (2011)

Shea butter is a versatile plant fat extracted from kernels of shea nuts, seeds of shea trees (Vitellaria paradoxa). Shea butter has long been used in sub-Saharan Africa for medicinal, culinary, and other applications and serves as a cocoa butter equivalent in the manufacture of chocolate as well as an ingredient in cosmetics. Shea butter, rich in unsaturated fatty acids undergoes hydrolytic and oxidative degradation during post-harvest processing and storage, resulting in inconsistent and degraded quality and limited shelf-life. The objective of this study was to assess important quality characteristics of shea butter. Seven West African shea butters were analyzed to measure physicochemical parameters by wet chemical tests and to measure chemical composition by gas chromatographic analysis. Physical properties were consistent among samples and within the range of typical shea butter. The samples also shared similar chemical compositions, showing palmitic (3.36-4.44 % of total fatty acids), stearic (39.74-44.62 %), oleic (40.71-44.48 %), and linoleic acids (5.73-6.41 %) as the major fatty acids and α-amyrin having anti-inflammatory property (57.26-64.37 % of total sterols and triterpenes) as the major unsaponifiable matter. Moisture, insoluble impurities, free fatty acids, and peroxide values were needed to be controlled. Free fatty acid level was the most variable parameter, ranged from 1.07 to 8.56 %. Peroxide value was low enough except the one which was as high as 15.32 mEq/kg. Total unsaponifiable matters were measured lower (2.21-4.18 %) compared to the previous studies (4-11 %) but still higher than many other plant oils and fats (~2 %). This study also aimed at identifying the protective effect of selected synthetic (BHT) and natural (rosmarinic and gallic acids) antioxidants on shea butter from oxidation. Peroxide value, conjugated dienes, thiobarbituric acid reactive substances, and the amount of major fatty acids were measured as oxidative parameters at 0, 72 and 144 hours while the control and samples with 0.02 % of antioxidants were stored at 90 °C with air flow. The antioxidants were significantly effective in protecting shea butter from oxidation and no significant difference in the effect of synthetic and natural antioxidants was found.
A clinical study to evaluate the usefulness of the MAST test in diagnosing pre-labour rupture of membranes (1998)

An open study was performed to evaluate the efficiency of insulin-like growth factor binding protein-1 as a marker for the detection of pre-labour rupture of membranes and to assess whether it aided the subsequent clinical management. One hundred women between 24 and 42 weeks' gestation with a history suggestive of pre-labour rupture of membranes were studied. There were 11 false positive and no false negative results and the sensitivity and specificity were 100% and 89% respectively. The presence of infection, blood or semen did not interfere with the accuracy of the results.
400-Hz mechanical scanning optical delay line (1993)

We have developed a simple, high-speed, nearly vibration-free, mechanically scanned, optical delay line suitable for femtosecond time-resolved signal-averaging measurements. We demonstrate a 2-ps time window autocorrelator with a display updated at 400 Hz. The delay line uses a dithering planar mirror as a time-varying linear phase ramp in the spectral plane of a modified grating-lens femtosecond pulse shaper. The time delay is linearly proportional to the angular deviation of the mirror. The high speed and low vibration are a result of the extremely small angular changes required to generate a large time delay.
Backcalculation of Pavement Layer Properties (1989)

This was prepared for the symposium as a state-of-the-art paper. The paper summarizes the history and present use of nondestructive testing (NDT) and speculates on future developments and uses of NDT in backcalculating pavement layer properties. The paper concentrates on the backcalculation of the elastic stiffness of pavement layers. Measurement methods include a variety of methods of applying loads to the pavement and a number of sensors of the pavement response. Loading methods include static or slowly moving loads, vibration, near field impulse, and wave propagation which applies to far field measurements. A fundamental distinction is drawn between near field impulse loads which closely simulate traffic loads and far field impulse loads, the results of which must be corrected substantially to provide realistic pavement layer moduli. Analysis methods are surveyed, including some historical methods, microcomputer methods, impulse and response analysis methods, and systems identification methods. The historical methods include two-layer closed form and graphical methods, equivalent layer methods, and a closed-form multilayered method that searches for the best set of moduli to satisfy a leastsquares criterion. Microcomputer methods are described generically, noting all of their common features, including methods of dealing with both random and systematic errors in measuring and computing layer moduli. Random errors can be reduced by repeating the measurements. Systematic errors include the assumptions used in the backcalculation process, including nonlinearity. The results of an exercise conducted to estimate the size of systematic errors is reported. Impulse and response methods analyze the complete signals to determine a “transfer function” of the pavement from which the complex moduli of the layers can be backcalculated. Some speculation is offered on how this information may be used to determine fatigue and permanent deformation properties of pavement layers. A systems identification method of analyzing far field measurements is illustrated. Uses of nondestructive testing in the future are envisioned to include layer thickness, asphalt or water content, density, elastic stiffness, creep compliance, fracture, and permanent deformation properties. A strategic objective of NDT methods is for them to become the primary method of measuring pavement material properties.
Parallel photonic information processing at gigabyte per second data rates using transient states (2013)

The increasing demands on information processing require novel computational concepts and true parallelism. Nevertheless, hardware realizations of unconventional computing approaches never exceeded a marginal existence. While the application of optics in super-computing receives reawakened interest, new concepts, partly neuro-inspired, are being considered and developed. Here we experimentally demonstrate the potential of a simple photonic architecture to process information at unprecedented data rates, implementing a learning-based approach. A semiconductor laser subject to delayed self-feedback and optical data injection is employed to solve computationally hard tasks. We demonstrate simultaneous spoken digit and speaker recognition and chaotic time-series prediction at data rates beyond 1 Gbyte/s. We identify all digits with very low classification errors and perform chaotic time-series prediction with 10% error. Our approach bridges the areas of photonic information processing, cognitive and information science.
Novel Substrate Specificity of Designer 3-Isopropylmalate Dehydrogenase Derived from Thermus thermophilus HB8 (2001)

Redesigning of an enzyme for a new catalytic reaction and modified substrate specificity was exploited with 3-isopropylmalate dehydrogenase (IPMDH). Point-mutation on Gly-89, which is not in the catalytic site but near it, was done by changing it to Ala, Ser, Val, and Pro, and all the mutations changed the substrate specificity. The mutant enzymes showed higher catalytic efficiency (kcat/Km) than the native IPMDH when malate was used as a substrate instead of 3-isopropylmalate. More interestingly, an additional insertion of Gly between Gly-89 and Leu-90 significantly altered the substrate-specificity, although the overall catalytic activity was decreased. Particularly, this mutant turned out to efficiently accept D-lactic acid, which was not accepted as a substrate by wild-type IPMDH at all. These results demonstrate the opportunity for creating nove,enzymes by modification of amino acid residues that do not directly participate in catalysis, or by insertion of additional residues.
Cellular control of abscess formation: role of T cells in the regulation of abscesses formed in response to Bacteroides fragilis. (1986)

Although abscesses are a major sequela of infection, little is known about which cellular events initiate and which prevent this pathologic response. These studies are the first to indicate a role for T cells in the important pathogenic process of abscess development and also in immunity to abscesses induced by Bacteroides fragilis. We have shown that T cells initiate the formation of abscesses in mice after i.p. challenge with B. fragilis. These T cells bear both Ly-1 and Ly-2 surface markers. Nude mice (which have been shown by others to have T cell or T cell precursors) are also able to form abscesses. Cyclophosphamide-treated mice (with depressed T cell function) were not capable of developing abscesses. Reconstitution with normal or nude mouse spleen cells restored this ability. However, reconstitution with anti-Thy-1.2-treated, anti-Ly-1, or anti-Ly-2-treated spleen cells (or a mixture of the two cell populations) failed to allow abscess formation after bacterial challenge. Immunity to abscesses caused by B. fragilis requires two T cells. The first Ly-1-2+ T cell has an IJ surface marker and has been shown to release a small m.w. soluble factor (ITF) that is antigen specific. Immunity to abscesses, however, depends on the interaction of ITF with a second Ly-1-2+ T cell, demonstrated in reconstitution experiments with nude mice. The data presented document a critical role for T cells in abscess induction and suggest the existence of a suppressor-like T cell circuit in immunity to abscesses.
Designing high bandwidth on-chip caches (1997)

In this paper we evaluate the performance of high bandwidth caches that employ multiple ports, multiple cycle hit times, on-chip DRAM, and a line buffer to find the organization that provides the best processor performance. Processor performance is measured in execution time using a dynamic superscalar processor running realistic benchmarks that include operating system references. The results show that a large dual-ported multi-cycle pipelined SRAM cache with a line buffer maximizes processor performance. A large pipelined cache provides both a low miss rate and a high CPU clock frequency. Dual-porting the cache and the use of a line buffer provide the bandwidth needed by a dynamic superscalar processor. In addition, the line buffer makes the pipelined dual-ported cache the best option by increasing cache port bandwidth and hiding cache latency.
Mutans Streptococci and Non-mutans Streptococci Acidogenic at Low pH, and in vitro Acidogenic Potential of Dental Plaque in Two Different Areas of the Human Dentition (1991)

Samples of human dental plaque were obtained from sound tooth surfaces in the lower anterior and upper posterior areas of each of 11 subjects with various degrees of caries experience. Both types of plaque were compared for: (1) their pH-lowering potential [pH at 10 and 60 min after sugar addition and the pH drop between 0 and 10 min (delta pH)] with an in vitro method involving dispersed plaque suspensions and excess glucose supply; (2) the proportions of mutans streptococci; and (3) the distribution of the predominant non-mutans streptococci according to their final pH in glucose broth. Compared with plaque from the lower anterior area, plaque from the upper posterior area exhibited a significantly higher pH-lowering potential, i.e., a lower pH at 10 and 60 min and a greater delta pH and significantly higher levels of mutans streptococci. The final pH values for the non-mutans streptococci exhibited a wide range from about 4.4 to over 5.0. The proportions of such organisms designated as capable of acidogenesis at low pH (final pH less than 4.6), whether expressed as a percentage of the total non-mutans streptococci or of the total plaque flora, were significantly increased in plaque from the upper posterior area. The proportions of non-mutans streptococci capable of acidogenesis at low pH in plaque from the upper posterior area were also significantly increased, with decreasing pH values at 10 and 60 min.(ABSTRACT TRUNCATED AT 250 WORDS)
Chemical synthesis and properties of stereoregulated phosphorothioate RNAs (2007)

Stereoregulated oligoribonucleoside phosphorothioates were synthesized by the use of 2'-O-TBDMS-protected ribonucleoside 3'-O-oxazaphospholidine derivatives as monomers and N-(cyanomethyl)ammonium salts as activators. Diastereoselectivity of the condensation reaction was found to be highly dependent on the substituent groups of the oxazaphospholidine ring as well as the structure of the activators. By the use of the optimized oxazaphospholidine monomers and activators, stereoregulated oligoribonucleoside phosphorothioates containing four kinds of nucleobases were synthesized in good yields. Hybridization properties of thus obtained oligomers with the complementary RNAs were evaluated by the UV melting experiments.
Topical Delivery of Silver Nanoparticles Promotes Wound Healing (2006)

Wound healing is a complex process and has been the subject of intense research for a long time. The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. Nonetheless, the beneficial effects of silver nanoparticles on wound healing remain unknown. We investigated the wound-healing properties of silver nanoparticles in an animal model and found that rapid healing and improved cosmetic appearance occur in a dose-dependent manner. Furthermore, through quantitative PCR, immunohistochemistry, and proteomic studies, we showed that silver nanoparticles exert positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation of fibrogenic cytokines. These results have given insight into the actions of silver and have provided a novel therapeutic direction for wound treatment in clinical practice.
A control system for automatic electrical stimulation of abdominal muscles to assist respiratory function in tetraplegia (2006)

People with tetraplegia have poor respiratory function leading to limited tidal volume (V(T)) and reduced cough peak flow (CPF). These problems may cause respiratory failure during the initial admission or subsequent intercurrent illness. Electrical stimulation of the abdominal muscles during expiration can improve respiratory function by increasing V(T) and CPF. We developed a novel control system to automatically trigger muscle stimulation, synchronised with the subject's voluntary respiratory activity. The system was tested in four subjects with a functionally complete lesion at level C4 to C6, aged between 16 and 46 years, 3 months to 5 years post injury, who were breathing spontaneously. The algorithm delivered automatic stimulation patterns, detecting cough and quiet breathing while suppressing stimulation during other activities such as speaking. Marked increases in V(T) (between 9% and 71% of baseline) and CPF (between 31% and 54% of baseline) were observed, suggesting that the technique may have potential use in both acute and established tetraplegia to increase minute ventilation and to improve cough clearance of secretions.