gebhart/patrepeval huggingface dataset:
Measurement and modeling of HF channel directional spread characteristics for northerly paths (2006)

The northerly ionosphere is a dynamic propagation medium that causes HF signals reflected from this region to exhibit delay spreads and Doppler shifts and spreads that significantly exceed those observed over midlatitude paths. Since the ionosphere is not perfectly horizontally stratified, the signals associated with each propagation mode may arrive at the receiver over a range of angles in both azimuth and elevation. Such large directional spreads may have a severe impact on radio systems employing multielement antenna arrays and associated signal‐processing techniques since the signal environment does not comprise a small number of specular components as often assumed by the processing algorithms. In order to better understand the directional characteristics of HF signals reflected from the northerly ionosphere, prolonged measurements have recently been made over two paths: (1) from Svalbard to Kiruna, Sweden, and (2) from Kirkenes, Norway, to Kiruna. An analysis of these data is presented in this paper. The directional characteristics are summarized, and consideration is given to modeling the propagation effects in the form of a channel simulator suitable for the testing of new equipment and processing algorithms.
Resveratrol activates SIRT1 in a Lamin A-dependent manner (2013)

Human sirtuin1 (SIRT1), the closest homolog of the yeast sir2 protein, functions as an NAD+-dependent histone and non-histone protein deacetylase in several cellular processes, like energy metabolism, stress responses, aging, etc. In our recent study, we have shown that lamin A (a major nuclear matrix protein) directly binds with and activates SIRT1. Resveratrol, a natural phenol, has long been known as an activator of SIRT1. However, resveratrol's direct activation of SIRT1 has been refuted several times. In our study, we have provided a mechanistic explanation to this question, and have shown that resveratrol activates SIRT1 by increasing its binding with lamin A, thus aiding in the nuclear matrix (NM) localization of SIRT1. We have also shown that rescue of adult stem cell (ASC) decline in laminopathy-based premature aging mice by resveratrol is SIRT1-dependent. Further, resveratrol's ameliorating effects on progeria and its capacity to extend lifespan in progeria mice has been established. Here we have summarized these findings and their probable implications on other aspects, like chromatin remodeling, stem cell therapy, DNA damage responses, etc.
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs (2006)

Nicotine dependence is one of the world's leading causes of preventable death. To discover genetic variants that influence risk for nicotine dependence, we targeted over 300 candidate genes and analyzed 3713 single nucleotide polymorphisms (SNPs) in 1050 cases and 879 controls. The Fagerström test for nicotine dependence (FTND) was used to assess dependence, in which cases were required to have an FTND of 4 or more. The control criterion was strict: control subjects must have smoked at least 100 cigarettes in their lifetimes and had an FTND of 0 during the heaviest period of smoking. After correcting for multiple testing by controlling the false discovery rate, several cholinergic nicotinic receptor genes dominated the top signals. The strongest association was from an SNP representing CHRNB3, the beta3 nicotinic receptor subunit gene (P = 9.4 x 10(-5)). Biologically, the most compelling evidence for a risk variant came from a non-synonymous SNP in the alpha5 nicotinic receptor subunit gene CHRNA5 (P = 6.4 x 10(-4)). This SNP exhibited evidence of a recessive mode of inheritance, resulting in individuals having a 2-fold increase in risk of developing nicotine dependence once exposed to cigarette smoking. Other genes among the top signals were KCNJ6 and GABRA4. This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies.
Location systems for ubiquitous computing (2001)

This survey and taxonomy of location systems for mobile-computing applications describes a spectrum of current products and explores the latest in the field. To make sense of this domain, we have developed a taxonomy to help developers of location-aware applications better evaluate their options when choosing a location-sensing system. The taxonomy may also aid researchers in identifying opportunities for new location-sensing techniques.
Bioelectronic DNA detection of human papillomaviruses using eSensor™: a model system for detection of multiple pathogens (2003)

This model system demonstrates the potential of the eSensor platform for rapid and integrated detection of multiple pathogens.
<title>Efficient voxel lookup in nonuniformly spaced images using virtual uniform axes</title> (2001)

Medical image data is usually represented by a uniformly spaced grid of voxels. However, CT scanners for example are capable of producing non-uniformly spaced slice images. This is desirable when for a particular patient some regions (lesions) need to be imaged with a high resolution, while a lower resolution would be sufficient in other areas. Such an adaptive slice spacing can significantly reduce X-ray dose, thus directly benefitting the patient. Unfortunately, computational handling of the resulting volume data is far less efficient than that of uniformly spaced images. To deal with this problem, the present paper introduces a novel data structure for non-uniformly spaced image coordinates, the so-called virtual uniform axes. By a generalization of Euclid's greatest common divider (GCD) algorithm, a table of virtual voxels on a uniform grid is produced. Each of the uniform voxels in the virtual grid holds a pointer to the corresponding voxel in the original, non-uniform grid. Finding a voxel in the virtual uniform image can be done in constant time as compared to logarithmic time for finding a voxel in a non-uniform image. This is achieved with significantly less additional storage than by resampling the image data itself to a uniform grid. Interpolation artifacts are also completely avoided.
Software security checklist for the software life cycle (2004)

A formal approach to security in the software life cycle is essential to protect corporate resources. However, little thought has been given to this aspect of software development. Traditionally, software security has been treated as an afterthought leading to a cycle of 'penetrate and patch.' Due to its criticality, security should be integrated as a formal approach in the software life cycle. Both a software security checklist and assessment tools should be incorporated into this life cycle process. The current research at JPL addresses both of these areas through the development of a Software Security Assessment Instrument (SSAI). This paper focuses on the development of a Software Security Checklist (SSC) for the life cycle. It includes the critical areas of requirements gathering and specification, design and code issues, and maintenance and decommissioning of software and systems.
Haemophilus influenzae adheres to and enters cultured human epithelial cells (1990)

Haemophilus influenzae is a common commensal organism of the human respiratory tract that initiates infection by colonizing the nasopharyngeal epithelium. In some individuals, colonization is followed by localized respiratory tract or systemic disease. To gain insight into the mechanisms by which H. influenzae attaches to and persists within the nasopharynx, we examined the interactions between a nonpiliated clinical isolate of H. influenzae and human epithelial cells. We noted substantial adherence that occurred independently of pili and required viable bacteria capable of de novo protein synthesis. Comparison of profiles of outer membrane proteins synthesized during incubation with epithelial cells for adherent and nonadherent bacteria identified several candidate adhesin molecules. In addition, a small number of adherent bacteria were capable of entering epithelial cells in a process that was inhibited by cytochalasin D and colchicine. The suggestion from our studies is that one or more of several newly synthesized nonpilus bacterial proteins are required for maximal in vitro adherence and invasion. We speculate that H. influenzae entry into epithelial cells may provide a mechanism for evasion of host defenses, thereby allowing persistence in the nasopharynx.
Microarray Profiling of DNA Extracted from FFPE Tissues Using SNP 6.0 Affymetrix Platform (2011)

High-density oligonucleotide microarrays are commonly used for GWAS studies as well as for tumor genome alteration identifications. The recent Affymetrix Genome-Wide SNP 6.0 microarray generation has two major advantages: (1) showing high genome coverage and (2) starting with very small amount of DNA material. The hybridization protocol needs to be standardized and highly reproducible, as DNA is first digested by restriction enzymes and then PCR-amplified to reduce genome complexity. Especially the restriction digestion step is highly sensitive to degradation of the initial material. The stronger the sample is degraded, the lower the number of restriction sites still present in the genome, and hence the less-efficient amplification step.Paraffin-embedded material generally only allows to extract partially degraded DNA, and therefore is difficult to analyze using SNP array technology. We and others (Jacobs et al., Cancer Res 67:2544-2551, 2007; Tuefferd et al., Genes Chromosomes Cancer 47:957-964, 2008) have shown that target preparation protocol can be adjusted to improve hybridization performances. The final in silico data analysis procedure should be modified accordingly to extract most of the biological information from the signal measured. By optimizing these crucial steps, it is possible to use Affymetrix SNP array 6.0 -technology in the context of genome variation, even for FFPE partially degraded material. This opens a lot of potential for large retrospective series of samples.
Protective effects of ellagic acid and other plant phenols on benzo[a]pyrene-induced neoplasia in mice (1983)

The inhibitory effects of three phenolic compounds (ferulic, chlorogenic and ellagic acids) on benzo[a]pyrene- and 7,12-dimethylbenz[a]anthracene-induced neoplasia have been investigated in mice. Ellagic acid was the most potent antagonist of tumorigenesis since this compound is active, by i.p. administration or added in the diet, on benzo[a]pyrene-induced pulmonary adenoma formation in A/J mice and, after topical application, on 7,12-dimethylbenz[a]anthracene-induced skin tumorigenesis in NMRI Swiss mice. If ellagic acid has little or no effect on the number of tumor bearing animals, the incidence of pulmonary tumors per animal is decreased by greater than 50%. Ferulic acid and chlorogenic acid (5 X 100 mg/kg, by i.p. route) were also active, but less than ellagic acid, against the lung carcinogenesis by benzo[a]-pyrene (100 mg/kg, i.p.) but were totally ineffective against the formation of skin tumors by 7,12-dimethylbenz[a]anthracene. These results remarkably paralleled the in vitro antimutagenic effects of these compounds shown by Wood et al. on benzo[a]pyrene. It must be noted that ellagic acid only exerted, by i.p. route, a severe toxicity after four injections of 100 mg/kg, in oil suspension, whereas the oral administration in the diet (a daily dose of 100 mg/kg during 15 days) did not cause any toxicity.
High syndecan‐1 expression in breast carcinoma is related to an aggressive phenotype and to poorer prognosis (2003)

Syndecan-1 is expressed at high levels in a significant percentage of breast carcinomas and is related to an aggressive phenotype and poor clinical behavior.
Roots of Clinical Resistance to STI-571 Cancer Therapy (2001)

STI-571, a new Abl tyrosine kinase inhibitor recently approved by the Food and Drug Administration, is highly effective in treating the early stages of chronic myeloid leukemia (CML), but remissions induced in advanced phases tend to be relatively short-lived, an observation that suggests the
EL PSICOANÁLISIS FREUDIANO: UN ACONTECIMIENTO EN LA PSICOLOGÍA (2009)

En este ensayo se analiza la repercusion que segun Foucault tuvo la “violencia soberana” que ejercio Sigmund Freud en la psicologia del siglo XX; el texto se basa fundamentalmente en las consideraciones que realiza el filosofo frances en sus primeros textos publicados, especialmente en los articulos de 1957 “La psicologia de 1850 a 1950” y “La Investigacion cientifica y la psicologia”. Se observara que para Foucault, la transcendencia del psicoanalisis freudiano en la psicologia resulta absolutamente incuestionable y determinante. En la parte final del texto, se mencionan algunas de las tesis que Foucault elaboro para explicar el poder de influencia que segun el tuvo el psicoanalisis freudiano sobre el saber psicologico y las ciencias humanas en general. 

Abstract
In this sumary is analized the repercusion that Foucault said have had the “supreme violence”, that Sigmund Freud developed in the psychology of xx century; The text is fundamentally based in the considerations performed for the french philosopher in his first texts publishied, specially in the articles from 1957 “Psychology from 1850 to 1950’’ and the “scientific investigation and the psychology”. It will notice that for Foucault, the transcendencia from psychoanalysis freudiano in the psychology is absolutely inquestionable and determining. In the last part of the text, is mentioned some of the tesis that Foucault developed for explain the power of the influence according to him, had the psychoanalysis freudiano, about psychological knowledge and the humanity sciences in general.
Up regulation in gene expression of chromatin remodelling factors in cervical intraepithelial neoplasia (2008)

We have created a valuable publically available resource for the study of gene expression in precancerous cervical lesions. Our results indicate deregulation of the chromatin remodelling complex components and its influencing factors occur in the development of CIN lesions. The increase in SWI/SNF stabilizing molecule SMARCC1 and other novel genes has not been previously illustrated as events in the early stages of dysplasia development and thus not only provides novel candidate markers for screening but a biological function for targeting treatment.
In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity (1988)

Site-specific mutagenesis was used to introduce amino acid substitutions at the asparagine codons of four conserved potential N-linked glycosylation sites within the gp120 envelope protein of human immunodeficiency virus (HIV). One of these alterations resulted in the production of noninfectious virus particles. The amino acid substitution did not interfere with the synthesis, processing, and stability of the env gene polypeptides gp120 and gp41 or the binding of gp120 to its cellular receptor, the CD4 (T4) molecule. Vaccinia virus recombinants containing wild-type or mutant HIV env genes readily induced syncytia in CD4+ HeLa cells. These results suggest that alterations involving the second conserved domain of the HIV gp120 may interfere with an essential early step in the virus replication cycle other than binding to the CD4 receptor. In long-term cocultures of a T4+ lymphocyte cell line and colon carcinoma cells producing the mutant virus, revertant infectious virions were detected. Molecular characterization of two revertant proviral clones revealed the presence of the original mutation as well as a compensatory amino acid change in another region of HIV gp120.
Cloning, expression and characterization of the Fv fragments of the anti-carbohydrate mAbs Bl and B5 as single-chain immunotoxins (1994)

The mAbs B1 (IgG1 kappa) and B5 (IgM kappa) recognize carbohydrate epitopes on human carcinoma cells. The Fv regions of these antibodies were separately cloned from hybridoma RNA using reverse transcription and PCR with oligonucleotide primers designed according to the amino acid sequences of the N-termini. The Fv regions also provide sequences for translation initiation in Escherichia coli (Fr1 oligos) and sequences of the constant region of the heavy and light domains (CH1 or C-kappa oligos). Following the determination of the DNA sequence of the Fvs, primers were designed according to the 3' ends of the VH and VL domains. These also provided for a peptide linker at the C-terminus of the VH and a short connector at the C-terminus of the VL (Fr4 oligos). The VH and VL were then each PCR-amplified using their corresponding Fr1 and phosphorylated Fr4 oligos. The resulting PCR products were annealed as 'mutagenic primers' to a uracil-containing single-stranded template obtained from an expression plasmid encoding a single-chain immunotoxin in which the B3 single-chain Fv is fused to a truncated form of Pseudomonas exotoxin (PE). Thus, the B1 and B5 variable domains replaced their corresponding B3 domains in the expression plasmid by 'variable domain shuffling' without subcloning. The resulting B1(Fv)-PE38 and B5(Fv)-PE38 were expressed in E. coli and purified to near homogeneity. Both show specific cytotoxicities to human carcinoma cell lines, but B1(Fv)-PE38 is much more active, reflecting its higher affinity to the target cells.
Isolation and characterization of an immortalized mouse urogenital sinus mesenchyme cell line (2006)

UGSM-2 is a urogenital sinus mesenchyme cell line that can be used to study stromal-epithelial interactions that are important in prostate biology.
Risk of non-Hodgkin lymphoma subtypes in HIV-infected people during the HAART era (2014)

HIV-infected people in the HAART era continue to have elevated risk of AIDS-defining NHL subtypes, highlighting the contribution of moderate and severe immunosuppression to their cause. Whereas non-AIDS-defining subtypes are much less common, immunosuppression or other dysregulated immune states likely play a role in the cause of some T-cell lymphomas, marginal zone lymphoma, lymphoplasmacytic lymphoma/Waldenström macroglobulinemia, and acute lymphoblastic leukemia/lymphoma.
The cyclooxygenase 2-selective inhibitor NS398 inhibits proliferation of oral carcinoma cell lines by mechanisms dependent and independent of reduced prostaglandin E2 synthesis. (2003)

NS398 inhibits the growth of OSCC cells by mechanisms that are dependent and independent of suppression of PGE(2) synthesis. Molecular targeting of COX-2, PGE(2) synthase, or PGE(2) receptors may be useful as a chemopreventive or therapeutic strategy for oral cancer.
Synthetic factor VIII peptides with amino acid sequences contained within the C2 domain of factor VIII inhibit factor VIII binding to phosphatidylserine (1990)

The effective activation of factor X by factor IXa requires the co-factor activity of activated factor VIII (FVIII). Factor Xa formation is also dependent on the presence of negatively charged phospholipid. A phospholipid binding domain of FVIII has been reported to be present on the FVIII light chain. Recent observations on a subset of human FVIII inhibitors have implicated the carboxyl-terminal C2 domain of FVIII as containing a possible phospholipid binding site. The purpose of this study was to investigate directly the role of the C2 domain in phospholipid binding. Twenty-six overlapping peptides, which span the entire C2 domain of FVIII, were synthesized. The ability of these peptides to inhibit the binding of purified human FVIII to immobilized phosphatidylserine was evaluated in an enzyme-linked immunosorbent assay. Three overlapping synthetic FVIII peptides, 2303-2317, 2305-2332, and 2308-2322, inhibited FVIII binding to phosphatidylserine by greater than 90% when tested at a concentration of 100 mumols/L. A fourth partially overlapping peptide, 2318-2332, inhibited FVIII binding by 65%. These results suggest that the area described by these peptides, residues 2303 to 2332, may play an important role in the mediation of FVIII binding to phospholipid.
Molecular Assemblies on Silicon Surfaces via Si−O Linkages (2000)

Monolayer assemblies on silicon surfaces are of interest for a number of technological reasons. Here, we present a novel, two-step strategy for assembly formation directly on silicon surfaces. In the first step, a H-terminated Si(100) or Si(111) surface reacts with Cl2 to give a Cl-capped surface. In the second step, the Cl−Si surface is immersed in an alcohol/isooctane solution for monolayer formation via Si−O linkages, with the removal of surface Cl likely in the form of HCl. This reaction mechanism is confirmed by X-ray photoelectron spectroscopy. X-ray reflectivity measurement shows that the thickness of the monolayer film is close to molecular dimension and the density is about 85% of that in crystalline paraffine. Fourier transform infrared spectroscopy and water contact angle measurements suggest that the alkyl chains within the monolayer possess, to a limited degree, conformational order. Atomic force microscopy image with molecular lattice resolution shows intermolecular distance corresponding to close packing of alkyl chains. The monolayer coatings show both chemical and mechanical stability. The possible mechanism for monolayer assembly formation on covalent Si surfaces is discussed.
Journalism says goodbye to ‘Redskins’ (2014)

The article lists U.S. journalistic outlets and journalists who have stopped using the name of the Washington, D.C. football team Redskins, including journalist Bill Simmons and the newspapers Orange County Register and Washington City Paper.
Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? (2006)

Recent molecular analyses of leukemic blasts from pretreatment marrow or blood of patients with acute myeloid leukemia (AML) and a normal karyotype, the largest cytogenetic subset (ie, 40%-49%) of AML, have revealed a striking heterogeneity with regard to the presence of acquired gene mutations and changes in gene expression. Multiple submicroscopic genetic alterations with prognostic significance have been discovered, including internal tandem duplication of the FLT3 gene, mutations in the NPM1 gene, partial tandem duplication of the MLL gene, high expression of the BAALC gene, and mutations in the CEBPA gene. Application of gene-expression profiling has also identified a gene-expression signature that appears to separate cytogenetically normal AML patients into prognostic subgroups, although gene-expression signature-based classifiers predicting outcome for individual patients with greater accuracy are needed. These and similar future findings are likely to have a major impact on the clinical management of cytogenetically normal AML not only in prognostication but also in selection of appropriate treatment, since many of the identified genetic alterations already constitute or will potentially become targets for specific therapeutic intervention. In this report, we review prognostic genetic findings in karyotypically normal AML and discuss their clinical implications.
Age but Not Diagnosis Is the Main Predictor of Plasma Amyloid β-Protein Levels (2003)

Plasma Abeta measures increase with age, but, in contrast to reports on familial AD, plasma Abeta measures were neither sensitive nor specific for the clinical diagnosis of mild cognitive impairment or sporadic AD.