gebhart/patrepeval huggingface dataset:
Cognitive Eects on the Neurophysiology and Biomechanics of Stroke Recovery (2004)

Motor function recovery after stroke typically plateaus after six months. Case reports suggest that hypnosis has the potential to stimulate further recovery of function beyond this period. A pilot clinical investigation of hypnosis-aided recovery of motor function after stroke is presented. Baseline hand motor performance was quantified for six stroke subjects with a force-following task. Brain activity during the task was measured using functional magnetic resonance imaging (fMRI). After cognitive training with hypnosis for improved motor performance, subjects performed the task again. Reaction times and muscle contraction and relaxation rates improved significantly after hypnosis and changes persisted during follow up testing at two weeks. Hypnosis versus baseline fMRI results show increased activation extent in bilateral sensorimotor cortex with an ipsilateral shift in laterality. No significant differences were found in motor performance or fMRI results when the unaffected hand performed the task as a control condition. The autonomic physiology of hypnosis was studied by correlating heart rate variability (HRV) model parameters with hypnotic depth and motor performance changes. Modeling the low frequency (LF) and high frequency (HF) components in HRV as
Interconnection between gain spectrum and cavity mode in a quantum-dot vertical-cavity laser (1999)

The effect of self-adjustment of the cavity mode in vertical cavity surface-emitting lasers containing three-period InGaAs-GaAs vertically-coupled quantum dots has been observed. The effect originates from a strong modulation of the refractive index near the gain peak, caused by excitons in quantum dots. The possibility of single quantum dot lasing is demonstrated.
Glass micro‐fibers: A model system for study of early events in myelination (1990)

A system was developed to analyze early events in the process of myelination. Primary cultures of rat oligodendrocytes were maintained in the presence of glass micro-fibers which served as artificial axons. A culture chamber was constructed which allowed the close apposition of fibers and cells in a three-dimensional arrangement designed to resemble an in vivo environment. Cells cultured in the presence of glass micro-fibers coated with a glial cell matrix extract were induced to organize into clusters around the fibers. Examination of oligodendrocyte-fiber sandwiches by SEM revealed the presence of a number of cell contacts with the fibers. TEM images showed that, in most cases, fibers were surrounded by the cells and not multiply wrapped. Only occasionally was a loose wrapping of cell membrane observed around the fibers. Cells cultured in the presence of matrix-coated glass micro-fibers showed an increased production of sulfolipids that was at least partially dependent on the presence of the matrix coating. Coating of these "artificial axons" may aid in the identification of signal molecules produced by neurons which enable them to be myelinated.
Investigation of IPMSM's Position Estimation in Low Speed Region with DC Link Current Detection (2007)

This paper presents a new method to estimate the pole position of an interior permanent magnet synchronous machine, IPMSM. The proposed method uses the three phase triangular carrier waves for the PWM signal generation and measures only the current of the DC link of the inverter. The DC link current can be measured with an inexpensive current sensor such as a shunt resistor. The proposed method enables to estimate the pole position at low speeds and standstill. In this paper, first, authors verify the validity of the proposed method by the experiment, and compensate the position estimation. The proposed method needs the current detection at tops and bottoms of carrier waves, precisely. So, the method is investigated in this theory about the effect of the current detection timing delay. And the ways to compensate the timing delay is explored.
DNA Sequencing and Analysis of the Low-Ca2+-Response Plasmid pCD1 ofYersinia pestisKIM5 (1998)

The low-Ca2+-response (LCR) plasmid pCD1 of the plague agent Yersinia pestis KIM5 was sequenced and analyzed for its genetic structure. pCD1 (70,509 bp) has an IncFIIA-like replicon and a SopABC-like partition region. We have assigned 60 apparently intact open reading frames (ORFs) that are not contained within transposable elements. Of these, 47 are proven or possible members of the LCR, a major virulence property of human-pathogenic Yersinia spp., that had been identified previously in one or more of Y. pestis or the enteropathogenic yersiniae Yersinia enterocolitica and Yersinia pseudotuberculosis. Of these 47 LCR-related ORFs, 35 constitute a continuous LCR cluster. The other LCR-related ORFs are interspersed among three intact insertion sequence (IS) elements (IS100 and two new IS elements, IS1616 and IS1617) and numerous defective or partial transposable elements. Regional variations in percent GC content and among ORFs encoding effector proteins of the LCR are additional evidence of a complex history for this plasmid. Our analysis suggested the possible addition of a new Syc- and Yop-encoding operon to the LCR-related pCD1 genes and gave no support for the existence of YopL. YadA likely is not expressed, as was the case for Y. pestis EV76, and the gene for the lipoprotein YlpA found in Y. enterocolitica likely is a pseudogene in Y. pestis. The yopM gene is longer than previously thought (by a sequence encoding two leucine-rich repeats), the ORF upstream of ypkA-yopJ is discussed as a potential Syc gene, and a previously undescribed ORF downstream of yopE was identified as being potentially significant. Eight other ORFs not associated with IS elements were identified and deserve future investigation into their functions.
Some factors that influence EHF SATCOM systems (1979)

Frequency management problems, scarcity of orbital position assignment, and resistance to interfering signals are projected to become serious problems for satellite communication (SATCOM) systems operating below about 15 GHz. International frequency allocations in the 15-50 GHz range permit SATCOM system operation with increased frequency bandwidth and hence may eliminate significant frequency management problems. This paper addresses some of the salient factors that influence SATCOM systems operating over the range 7-50 GHz. Propagation losses, frequency variation of a terminal's EIRP, spatial discrimination, and band-width available for spread spectrum AJ are presented as a guide to choosing the operating frequency of an EHF SATCOM system.
Measuring the end-to-end performance of digital video systems (1997)

Significant research and development efforts by industry and government laboratories were brought to fruition in 1996 with the approval of the American National Standard (ANSI) T1.801.03 entitled "American National Standard for Telecommunications-Digital Transport of One-Way Video Signals-Parameters for Objective Performance Assessment." This standard provides a set of objective parameters that have consistently demonstrated high correlation levels with subjective evaluations of digital video impairments. The parameters are technology-independent and may be used to measure the performance of a wide range of digital video compression, storage, and transmission systems. This paper presents an overview of the ANSI T1.801.03 parameters and summarizes other relevant standards activities and contributions.
Tropism of human adenovirus type 5-based vectors in swine and their ability to protect against transmissible gastroenteritis coronavirus (1996)

The infection of epithelia] swine testicle and intestinal porcine epithelial (IPEC-1) cell lines by adenovirus type 5 (Ad5) has been studied in vitro by using an Ad5-luciferase recombinant containing the firefly luciferase gene as a reporter. Porcine cell lines supported Ad5 replication, showing virus titers, kinetics of virus production, and luciferase expression levels similar to those obtained in human 293 cells, which constitutively express the 5'-end 11% of the Ad5 genome. The tropism of Ad5-based vectors in swine and its ability to induce an efficient immune response against heterologous antigens expressed by foreign genes inserted in these vectors has been determined. Ad5 vectors replicate and express heterologous antigens in porcine lungs and mediastinal and mesenteric lymph nodes. Significant levels of heterologous antigen expression were also demonstrated in the small intestine (jejunum and ileum), but Ad5 replication in this organ was very poor, suggesting that Ad vectors undergo an abortive replication in the porcine small intestine. The tissues infected by Ad5 were dependent on the inoculation route. The oronasal route appeared to be best for inoculation of bronchus-associated lymphoid tissue infection, while the intraperitoneal route was best for gut-associated lymphoid tissue infection. Epithelial cells of bronchioles, macrophages, type II pneumocytes, and follicular dendritic cells were identified as targets for Ad5, while epithelial cells of the intestine were not infected by Ad5. Viruses with a deletion from 79.5 to 84.8 map units in the E3 region, with or without heterologous inserted genes, replicated to lower levels in porcine tissues than did wild-type Ad5. It was also shown that an Ad5 recombinant expressing the four antigenic sites (A, B, C, and D) of transmissible gastroenteritis coronavirus (TGEV) spike protein induced in swine immune responses which neutralized TGEV infectivity. In addition, porcine serum from Ad-TGEV-immune animals provide passive protection when mixed with fully virulent TGEV and orally administered to highly susceptible newborn piglets. These results taken together indicate that swine may be a good animal model for human Ad5 lung infection to aid in the evaluation of candidate adenovirus vaccines and that Ad5 may be suitable as a recombinant viral vaccine or for other applications in swine.
Constituent boundary parsing for example-based machine translation (1994)

This paper proposes an effective parsing method for example-based machine translation. In this method, an input string is parsed by the top-down application of linguistic patterns consisting of variables and constituent boundaries. A constituent boundary is expressed by either a functional word or a part-of-speech bigram. When structural ambiguity occurs, the most plausible structure is selected using the total values of distance calculations in the example-based framework. Transfer-Driven Machine Translation (TDMT) achieves efficient and robust translation within the example-based framework by adopting this parsing method. Using bidirectional translation between Japanese and English, the effectiveness of this method in TDMT is also shown.
DNA Nanoparticles and Development of DNA Delivery Vehicles for Gene Therapy (2002)

DNA transport through the cell membrane is an essential requirement for gene therapy, which utilizes oligonucleotides and plasmid DNA. However, membrane transport of DNA is an inefficient process, and the mechanism(s) by which this process occurs is not clear. Although viral vectors are effective in gene therapy, the immune response elicited by viral proteins poses a major problem. Therefore, several laboratories are involved in the development of nonviral DNA delivery vehicles. These vehicles include polyamines, polycationic lipids, and neutral polymers, capable of condensing DNA to nanoparticles with radii of 20-100 nm. Although the structural and energetic forces involved in DNA condensation have been studied by physical biochemists for the past 25 years, this area has experienced a resurgence of interest in recent years because of the influx of biotechnologists involved in developing gene therapy protocols to combat a variety of human diseases. Despite an intense effort to study the mechanism(s) of DNA condensation using a variety of microscopic, light scattering, fluorescence, and calorimetric techniques, the precise details of the energetics of DNA nanoparticle formation and their packing assembly are not known at present. Future studies aimed at defining the mechanism(s) of DNA compaction and structural features of DNA nanoparticles might aid in the development of novel gene delivery vehicles.
Visible red and infrared light alters gene expression in human marrow stromal fibroblast cells (2015)

These studies demonstrate differential gene expression with different wavelengths, energy densities and cell types. These differences in gene expression have the potential to be exploited for therapeutic purposes and can help explain contradictory results in the literature when wavelengths, energy densities and cell types differ.
Engineering three-dimensional bone tissuein vitro using biodegradable scaffolds: Investigating initial cell-seeding density and culture period (2000)

New three-dimensional (3D) scaffolds for bone tissue engineering have been developed throughout which bone cells grow, differentiate, and produce mineralized matrix. In this study, the percentage of cells anchoring to our polymer scaffolds as a function of initial cell seeding density was established; we then investigated bone tissue formation throughout our scaffolds as a function of initial cell seeding density and time in culture. Initial cell seeding densities ranging from 0.5 to 10 x 10(6) cells/cm(3) were seeded onto 3D scaffolds. After 1 h in culture, we determined that 25% of initial seeded cells had adhered to the scaffolds in static culture conditions. The cell-seeded scaffolds remained in culture for 3 and 6 weeks, to investigate the effect of initial cell seeding density on bone tissue formation in vitro. Further cultures using 1 x 10(6) cells/cm(3) were maintained for 1 h and 1, 2, 4, and 6 weeks to study bone tissue formation as a function of culture period. After 3 and 6 weeks in culture, scaffolds seeded with 1 x 10(6) cells/cm(3) showed similar tissue formation as those seeded with higher initial cell seeding densities. When initial cell seeding densities of 1 x 10(6) cells/cm(3) were used, osteocalcin immunolabeling indicative of osteoblast differentiation was seen throughout the scaffolds after only 2 weeks of culture. Von Kossa and tetracycline labeling, indicative of mineralization, occurred after 3 weeks. These results demonstrated that differentiated bone tissue was formed throughout 3D scaffolds after 2 weeks in culture using an optimized initial cell density, whereas mineralization of the tissue only occurred after 3 weeks. Furthermore, after 6 weeks in culture, newly formed bone tissue had replaced degrading polymer.
Formation of acridine from the reaction of dibenz[b,f]azepine with silver(I); formation of an aromatic nitrenium ion? (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation of acridine from the reaction of dibenz[b,f]azepine with silver(I); formation of an aromatic nitrenium ion?Michael C. CannCite this: J. Org. Chem. 1988, 53, 5, 1112–1113Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/jo00240a040https://doi.org/10.1021/jo00240a040research-articleACS PublicationsRequest reuse permissionsArticle Views190Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Reversible Inhibitors of LSD1 as Therapeutic Agents in Acute Myeloid Leukemia: Clinical Significance and Progress to Date (2014)

In the 10 years since the discovery of lysine-specific demethylase 1 (LSD1), this epigenetic eraser has emerged as an important target of interest in oncology. More specifically, research has demonstrated that it plays an essential role in the self-renewal of leukemic stem cells in acute myeloid leukemia (AML). This review will cover clinical aspects of AML, the role of epigenetics in the disease, and discuss the research that led to the first irreversible inhibitors of LSD1 entering clinical trials for the treatment of AML in 2014. We also review recent achievements and progress in the development of potent and selective reversible inhibitors of LSD1. These compounds differ in their mode of action from tranylcypromine derivatives and could facilitate novel biochemical studies to probe the pathways mediated by LSD1. In this review, we will critically evaluate the strengths and weaknesses of published series of reversible LSD1 inhibitors. Overall, while the development of reversible inhibitors to date has been less fruitful than that of irreversible inhibitors, there is still the possibility for their use to facilitate further research into the roles and functions of LSD1 and to expand the therapeutic applications of LSD1 inhibitors in the clinic.
Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats (2010)

This study focuses on the effect of 'Diashis', a polyherbal formulation composed of eight medicinal plants for the management of streptozotocin (STZ)-induced diabetes in rats. As oxidative stress is one of the consequences of diabetes, the activities of hepatic antioxidant enzymes and metabolic enzymes were evaluated. Treatment with 'Diashis' in STZ-induced diabetic rats resulted in a significant (P < 0.01) recovery in the activities of hepatic hexokinase, glucose-6-phosphate dehydrogenase, and glucose-6-phosphatase along with correction in the levels of fasting blood glucose, glycated hemoglobin, and liver and skeletal muscle glycogen. The oxidative stress status in the liver was corrected by 'Diashis' which was highlighted by the recovery in the activities of catalase, peroxidase, and glutathione-S-transferase along with the correction in the quantity of thiobarbituric acid-reactive substances and conjugated diene. 'Diashis' was not found to have any metabolic toxicity. The antidiabetic effects of 'Diashis' were compared with those of the antidiabetic drug, 'Glibenclamide'.
Cold adaptation of proteins. Purification, characterization, and sequence of the heat-labile subtilisin from the antarctic psychrophile Bacillus TA41 (1994)

The gene of subtilisin S41, an alkaline protease secreted by the psychrophile Bacillus TA41, encodes for a preproenzyme of 419 amino acids residues. The nucleotide sequence and NH2- and COOH-terminal amino acid sequencing of the purified enzyme indicate that the mature subtilisin S41 is composed of 309 residues with a predicted M(r) = 31,224. Subtilisin S41 shares most of its properties with mesophilic subtilisins (structure of the precursor, 52% amino acid sequence identity, alkaline pH optimum, broad specificity, Ca2+ binding) but is characterized by a higher specific activity on macromolecular substrate, by a shift of the optimum of activity toward low temperatures, and by a low thermal stability. The enzyme also differs by an acidic pI (5.3) and the presence of one disulfide bond. It is proposed that the psychrophilic enzyme possesses a more flexible molecular structure when compared to mesophilic and thermophilic subtilases in order to compensate for the reduction of reaction rates at low temperatures. The model of subtilisin S41 indeed reveals several features able to induce a more flexible, heat-labile conformation: the occurrence of four extended surface loops, a very hydrophilic surface through 11 extra Asp residues, and the lack of several salt bridges and aromatic-aromatic interactions. The low affinity of the Ca1 calcium binding site (Kd(app) = 10(-6) M), resulting possibly from one chelating side chain substitution and the stacking of Gly residues, also reflect a less compact conformation. The difference of free energy of stabilization between subtilisin S41 and a mesophilic subtilisin suggests that the balance of exo- and endothermically formed weak bonds is critical for the enzyme flexibility.
Adapting multimedia Internet content for universal access (1999)

Content delivery over the Internet needs to address both the multimedia nature of the content and the capabilities of the diverse client platforms the content is being delivered to. We present a system that adapts multimedia Web documents to optimally match the capabilities of the client device requesting it. This system has two key components. 1) A representation scheme called the InfoPyramid that provides a multimodal, multiresolution representation hierarchy for multimedia. 2) A customizer that selects the best content representation to meet the client capabilities while delivering the most value. We model the selection process as a resource allocation problem in a generalized rate distortion framework. In this framework, we address the issue of both multiple media types in a Web document and multiple resource types at the client. We extend this framework to allow prioritization on the content items in a Web document. We illustrate our content adaptation technique with a web server that adapts multimedia news stories to clients as diverse as workstations, PDA's and cellular phones.
Content-independent task-focused recommendation (2001)

A technique that correlates database items to a task adds content-independent context to a recommender system based solely on user interest ratings. In this article, we present a task-focused approach to recommendation that is entirely independent of the type of content involved. The approach leverages robust, high-performance, commercial software. We have implemented it in a live movie recommendation site and validated it with empirical results from user studies.
No. 4 ESS: Mass Announcement Capability (1981)

We describe the mass announcement capability that has been introduced in No. 4 ESS beginning with the 4E5 generic. This capability allows various sponsors to provide services in which a large volume of callers can dial advertised numbers to listen to Public Announcement Service announcements, register their opinions via telephone calls, or participate in call-ins whereby randomly selected callers are connected to a celebrity for a live answer. Although these kinds of services are not new, they have usually been offered on a limited, individually engineered basis at high administrative cost to the telephone network. Mass announcement capability provides a general means to accommodate sponsor-provided announcement-related services which can be offered on a local, regional, or national basis.