gebhart/patrepeval huggingface dataset:
Updating Data Warehouses with Temporal Data (2008)

There has been a growing trend to use temporal data in a data warehouse for making strategic and tactical decisions. The key idea of temporal data management is to make data available at the right time with different time intervals. The temporal data storing enables this by making all the different time slices of data available to whoever needs it. Users with different data latency needs can all be accommodated. Data can be âfrozenâ via a view on the proper time slice. Data as of a point in time can be obtained across multiple tables or multiple subject areas, resolving consistency and synchronization issues. This paper will discuss implementations such as temporal data updates, coexistence of load and query against the same table, performance of load and report queries, and maintenance of views against the tables with temporal data.
Easy calculations of lod scores and genetic risks on small computers. (1984)

A computer program that calculates lod scores and genetic risks for a wide variety of both qualitative and quantitative genetic traits is discussed. An illustration is given of the joint use of a genetic marker, affection status, and quantitative information in counseling situations regarding Duchenne muscular dystrophy.
Interfacial Activity Assisted Surface Functionalization: A Novel Approach To Incorporate Maleimide Functional Groups and cRGD Peptide on Polymeric Nanoparticles for Targeted Drug Delivery (2010)

Nanoparticles formulated using poly(d,l-lactide-co-glycolide) (PLGA) copolymer have emerged as promising carriers for targeted delivery of a wide variety of payloads. However, an important drawback with PLGA nanoparticles is the limited types of functional groups available on the surface for conjugation to targeting ligands. In the current report, we demonstrate that the interfacial activity assisted surface functionalization (IAASF) technique can be used to incorporate reactive functional groups such as maleimide onto the surface of PLGA nanoparticles. The surface maleimide groups were used to conjugate cRGD peptide to nanoparticles. The cRGD peptide targets alpha(v)beta(3) integrins overexpressed on tumor vasculature and some tumor cells, and was used as model targeting ligand in this study. Incorporation of biologically active cRGD peptide on the surface of nanoparticles was confirmed by in vitro cell uptake studies and in vivo tumor accumulation studies. Functionalization of nanoparticles with cRGD peptide increased the cellular uptake of nanoparticles 2-3-fold, and this enhancement in uptake was substantially reduced by the presence of excess cRGD molecules. In a syngeneic mouse 4T1 tumor model, cRGD functionalization resulted in increased accumulation and retention of nanoparticles in the tumor tissue (nearly 2-fold greater area under the curve), confirming the in vivo activity of cRGD functionalized nanoparticles. In conclusion, the IAASF technique enabled the incorporation of reactive maleimide groups on PLGA nanoparticles, which in turn permitted efficient conjugation of biologically active cRGD peptide to the surface of PLGA nanoparticles.
Magnetic Resonance of 2-Hydroxyglutarate in IDH1 -Mutated Low-Grade Gliomas (2012)

Recent studies have indicated that a significant survival advantage is conferred to patients with gliomas whose lesions harbor mutations in the genes isocitrate dehydrogenase 1 and 2 (IDH1/2). IDH1/2 mutations result in aberrant enzymatic production of the potential oncometabolite D-2-hydroxyglutarate (2HG). Here, we report on the ex vivo detection of 2HG in IDH1-mutated tissue samples from patients with recurrent low-grade gliomas using the nuclear magnetic resonance technique of proton high-resolution magic angle spinning spectroscopy. Relative 2HG levels from pathologically confirmed mutant IDH1 tissues correlated with levels of other ex vivo metabolites and histopathology parameters associated with increases in mitotic activity, relative tumor content, and cellularity. Ex vivo spectroscopic measurements of choline-containing species and in vivo magnetic resonance measurements of diffusion parameters were also correlated with 2HG levels. These data provide extensive characterization of mutant IDH1 lesions while confirming the potential diagnostic value of 2HG as a surrogate marker of patient survival. Such information may augment the ability of clinicians to monitor therapeutic response and provide criteria for stratifying patients to specific treatment regimens.
Immunotherapy for myasthenia gravis: a murine model. (1986)

In vivo therapy with monoclonal antibody (mAb) GK1.5, which recognizes a glycoprotein antigen designated L3T4 on murine helper T lymphocytes, either prevented or suppressed the development of murine lupus, autoimmune encephalomyelitis, and collagen arthritis. The L3T4 antigen in the mouse is analogous to the human Leu-3/T4 antigen expressed on helper T lymphocytes, because they both participate in the T cell response to class II major histocompatibility complex (MHC) antigens. Class II MHC genes and I-A antigens mediate murine experimental autoimmune myasthenia gravis (EAMG) induced by acetylcholine receptor (AChR) autoimmunity. We studied the efficacy of mAb GK1.5 as an immunotherapeutic agent for murine EAMG. Therapy with mAb GK1.5 not only suppressed established autoimmunity to AChR but also prevented loss of muscle AChR in mice with EAMG. Moreover, permanent remission of clinical muscle weakness was induced if mAb GK1.5 therapy was initiated after the onset of clinical disease. Because the function of the Leu-3/T4 determinant on human helper T lymphocytes is analogous to the murine L3T4 determinant, use of antibody to the Leu-3/T4 determinant as an immunotherapeutic agent may provide a way to control the progression of human MG.
Preparation of active Langmuir-Blodgett films of glucose oxidase (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of active Langmuir-Blodgett films of glucose oxidaseSongcheng Sun, Phuoc Hoa Ho-Si, and D. Jed HarrisonCite this: Langmuir 1991, 7, 4, 727–737Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/la00052a022https://doi.org/10.1021/la00052a022research-articleACS PublicationsRequest reuse permissionsArticle Views302Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Potentially Life-Threatening Phosphate Diabetes Induced by Ferric Carboxymaltose Injection: A Case Report and Review of the Literature (2014)

We report the case of a 45-year-old female patient who developed phosphate diabetes after administration of ferric carboxymaltose. Ten days after the second dose, she complained of intense fatigue and blood analysis showed a phosphate plasma level of 0.93 mg/dL with phosphate excretion rate of 23%. She received phosphate supplementation which resulted in phosphate clearance improvement which persisted for two months. We reviewed other cases described in the literature and would draw attention to this rare but potentially life-threatening side effect.
Engineered films for display technologies (2003)

Flexible displays and flexible electronics is an area generating considerable interest at present. This article will discuss the requirements of a base substrate for flexible displays and contrast the plastic films that are being developed for this application. The review will cover how the surfaces and properties of the films are being engineered to make them suitable for laying down barrier coatings and for laying down thin film transistor arrays. The barrier technologies that are being developed and the issues facing the development of a “flexible glass” will be discussed.
SOCP Approach for Reducing PAPR for MIMO-OFDM Via Tone Reservation (2011)

A combination of multiple-input multiple-output with orthogonal frequency division multiplexing has become a promising candidate for wireless communications.However, like OFDM, a serious disadvantage of the MIMO-OFDM system is the high Peak to Average Power Ratio (PAPR), which may severely affected the power efficiency of RF power amplifiers.In this paper, we proposed a novel method to reduce the PAPR based on the use of unused subcarriers.Accordingly, we formulated the reduction of the PAPR problem as space-time block codes approach (convex optimization).The reduction method is originally based on a particular case of Tone Reservation approach which uses the unused carriers of standards.Indeed, this approach does not degrade the bit-error-rate or the data rate and no side information is required.Besides, our approach is relatively simple, robust and precise and it achieved significant reduction in PAPR.In fact, we validated our approach on the WiMax systems and we compared our results with those found in the literature.Consequently, our proposed approach improved a PAPR reduction about 5 dB at the 10 -3 probability level.In addition, and precisely when using CCDF of signal technique optimized with constraint mean power vs.ߛ, the PAPR was reduced about 6dB.However and with previously works, a PAPR reduction has been obtained about 2.5 dB.
Technology for minimal access surgery (1999)

One of the important changes in medical practice over the past two decades has been the reduction in traumatic insult inherent in surgical interventions. The new surgical and interventional approaches are usually referred to as minimally invasive. However, this terminology is inappropriate for two reasons. Firstly, it carries connotations of increased safety, which is not the case. Secondly, it is semantically incorrect since to invade is absolute, and indeed such interventions are as invasive as open surgery in terms of reach of the various organs and tissues. The hallmark of the new approaches is the reduction in the trauma of access. Hence, a more appropriate generic term is minimal access therapy.1 

#### Summary points

Minimal access therapy comprises minimal access surgery, interventional flexible endoscopy, and percutaneous interventional radiology

The main advantage is reduced trauma of access, which allows more rapid recovery

Imaging systems which allow surgeons to look down on the operating field help overcome mapping problems and improve performance

New instruments are being developed that give surgeons greater freedom of movement

Operating theatres need to be specially designed to cope with the new equipment

Minimal access therapy comprises several approaches, involves various disciplines, and cuts across the various specialties within these disciplines. In essence, however, it has three arms: minimal access surgery, interventional flexible endoscopy, and percutaneous interventional radiology. These therapeutic approaches are largely complementary, and increasingly they are used together to treat individual cases. The advent of minimal access therapy has emphasised the need to regroup existing specialists from different disciplines to form multidisciplinary disease related treatment groups—for example, gastrointestinal, cardiovascular, or musculoskeletal groups. Such groups would facilitate real progress and efficiency in management and treatment of many diseases.

Minimal access therapy aims to minimise the traumatic insult to the patient without compromising the safety and efficacy of the treatment …
Renal xanthine oxidoreductase activity during development of hypertension in spontaneously hypertensive rats (2004)

Renal XOR induction in SHRs does not precede the development of hypertension, but progress concomitantly with an increase in SBP. The results indicate a role for locally synthesized XOR in the development of hypertension-associated end-organ damage, but no major role in the development of hypertension.
Atomic layer deposition of Y2O3 films using heteroleptic liquid (iPrCp)2Y(iPr-amd) precursor (2014)

The Y<sub>2</sub>O<sub>3</sub> films grown with a new and heteroleptic liquid Y precursor, (iPrCp)<sub>2</sub>Y(iPr-amd), have been investigated with chemical properties of precursor, atomic layer deposition process, and material characterization of the deposited film and its non-volatile resistive switching behaviour.
Universal commands for telephony-based spoken language systems (2000)

article Universal commands for telephony-based spoken language systems Share on Author: Mike Cohen View Profile Authors Info & Claims ACM SIGCHI BulletinVolume 32Issue 2April 2000 pp 25–29https://doi.org/10.1145/360405.360432Online:01 April 2000Publication History 4citation56DownloadsMetricsTotal Citations4Total Downloads56Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Beta-adrenergic receptor blockers. Adverse effects and drug interactions. (1988)

Adverse effects of beta-adrenergic receptor blocking drugs can be divided into two categories: 1) those that result from known pharmacological consequences of beta-adrenergic receptor blockade; and 2) other reactions that do not appear to result from beta-adrenergic receptor blockade. Adverse effects of the first type include bronchospasm, heart failure, prolonged hypoglycemia, bradycardia, heart block, intermittent claudication, and Raynaud's phenomenon. Neurological reactions include depression, fatigue, and nightmares. It is not yet proven whether the beta 1-selective adrenergic blockers or those with partial agonist activity reduce the overall frequency of adverse reactions seen with propranolol. Patient age does not appear, in itself, to be associated with more beta-blocker side effects. Side effects of the second category are rare. They include an unusual oculomucocutaneous reaction and the possibility of oncogenesis. There are also many drugs that interact with beta-blockers, which may increase toxicity. Finally, there are specific patient characteristics where one beta-blocker may be more effective and safer than another.
Sialoadhesin-Deficient Mice Exhibit Subtle Changes in B- and T-Cell Populations and Reduced Immunoglobulin M Levels (2006)

Sialoadhesin (Sn, also called Siglec-1 or CD169) is a transmembrane receptor and the prototypic member of the Siglec family of sialic acid binding immunoglobulin-like lectins. It is expressed on specialized subsets of resident macrophages in hematopoietic and lymphoid tissues and on inflammatory macrophages. In order to investigate its function, we generated Sn-deficient mice and confirmed that these mice are true nulls by fluorescence-activated cell sorter analysis and immunohistochemistry. Mice deficient in Sn were viable and fertile and showed no developmental abnormalities. Analysis of cell populations revealed no differences in bone marrow, peritoneal cavity, and thymus, but there was a small increase in CD8 T cells and a decrease in B220-positive cells in spleens and lymph nodes of Sn-deficient mice. Furthermore, in spleen there was a slight decrease in follicular B cells with an increase in numbers of marginal zone B cells. B- and T-cell maturation as well as responses to stimulation with thioglycolate were only slightly affected by Sn deficiency. Immunoglobulin titers in Sn-deficient mice were significantly decreased for immunoglobulin M (IgM) but similar for IgG subclasses. These results suggest a role for sialoadhesin in regulating cells of the immune system rather than in influencing steady-state hematopoiesis.
A functional screen for recovery of 4′‐phosphopantetheinyl transferase and associated natural product biosynthesis genes from metagenome libraries (2012)

The single-module non-ribosomal peptide synthetase BpsA from Streptomyces lavendulae has the unique ability to autonomously synthesize a coloured product (indigoidine) from a single substrate (l-glutamine), conditional upon activation by a 4'-phosphopantetheinyl transferase (PPTase) partner. We show that bpsA can be expressed in an entD PPTase gene deleted mutant of Escherichia coli to yield a sensitive reporter strain for recovery of PPTase genes from metagenome libraries. We also show that recombinant bpsA constructs, generated by substitution of the native peptidyl carrier protein domain followed by directed evolution to restore function, can be used to increase the diversity of PPTase genes recovered from a sample. As PPTases are essential for activation of non-ribosomal peptide synthetase and polyketide synthase enzymes, they are frequently associated with secondary metabolite gene clusters. Nearly half of the PPTases recovered in our screening of two small-insert soil metagenome libraries were genetically linked to recognizable secondary metabolite biosynthetic genes, demonstrating that PPTase-targeting functional screens can be used for efficient recovery of natural product gene clusters from metagenome libraries. The plasticity and portability of bpsA reporter genes can potentially be exploited to maximize recovery and expression of PPTase-bearing clones in a wide range of hosts.
Effect of the Growth Temperature on the Diameter Distribution and Chirality of Single-Wall Carbon Nanotubes (1998)

Pulsed laser vaporization of a heated, Fe/Ni or Co/Ni catalyzed, carbon target in argon gas has been used to synthesize single-wall carbon nanotubes (SWNTs). Electron microscopy, x-ray diffraction, and Raman spectroscopy were all used to study the effect of the catalyst on the tube yield, and the evolution of the tube diameter distribution with increasing growth environment temperature $T$. By controlling the temperature in the range $780&lt;T&lt;1050\ifmmode^\circ\else\textdegree\fi{}\mathrm{C}$, we have been able to tune the diameter of the tubules from $\ensuremath{\sim}0.81$ to $\ensuremath{\sim}1.51\mathrm{nm}$. The threshold temperature for significant SWNT production was found to be $\ensuremath{\sim}850\ifmmode^\circ\else\textdegree\fi{}\mathrm{C}$.
Fabrication of Ordered Uniform Porous Carbon Networks and Their Application to a Catalyst Supporter (2002)

Ordered uniform porous carbon frameworks showing interesting morphology variations were synthesized against removable colloidal silica crystalline templates through simply altering acid catalyst sites for acid-catalyzed polymerization. These highly ordered uniform porous carbons as a catalyst supporter resulted in much improved catalytic activity for methanol oxidation in a fuel cell.
Ashing of Ion-Implanted Resist Layer (1989)

The stripping method of high-dose ion-implanted resist layers was studied on the basis of the chemical structure of carbonized layers formed by ion implantation and that of residues remaining on the wafer surface after O 2 plasma ashing. The chemical structure of the carbonized layer was observed with solid NMR and that of residues was analyzed with XPS. A decrease in the etching rate of the high-dose ion-implanted resist was caused by carbonization of polymers of the resist. Residues were mainly formed during O 2 plasma ashing by chemical reaction between oxygen and implanted species, i.e., the main component of residues was oxide of the implanted species. On the basis of these results, to remove the high dose ion implanted resist without damage, we developed a two-step ashing process which was composed of H 2 RIE and downstream ashing, and achieved the purpose.
Increased Circulating Nitrogen Oxides After Human Tumor Immunotherapy: Correlation With Toxic Hemodynamic Changes (1992)

Since .N = O synthesis can be competitively inhibited by L-arginine analogues, a possible pharmacologic modulation of .N = O production could potentially contribute to better management of toxic side effects seen in IL-2 cancer therapies.
In Situ Genetic Correction of the Sickle Cell Anemia Mutation in Human Induced Pluripotent Stem Cells Using Engineered Zinc Finger Nucleases (2011)

The combination of induced pluripotent stem cell (iPSC) technology and targeted gene modification by homologous recombination (HR) represents a promising new approach to generate genetically corrected, patient-derived cells that could be used for autologous transplantation therapies. This strategy has several potential advantages over conventional gene therapy including eliminating the need for immunosuppression, avoiding the risk of insertional mutagenesis by therapeutic vectors, and maintaining expression of the corrected gene by endogenous control elements rather than a constitutive promoter. However, gene targeting in human pluripotent cells has remained challenging and inefficient. Recently, engineered zinc finger nucleases (ZFNs) have been shown to substantially increase HR frequencies in human iPSCs, raising the prospect of using this technology to correct disease causing mutations. Here, we describe the generation of iPSC lines from sickle cell anemia patients and in situ correction of the disease causing mutation using three ZFN pairs made by the publicly available oligomerized pool engineering method (OPEN). Gene-corrected cells retained full pluripotency and a normal karyotype following removal of reprogramming factor and drug-resistance genes. By testing various conditions, we also demonstrated that HR events in human iPSCs can occur as far as 82 bps from a ZFN-induced break. Our approach delineates a roadmap for using ZFNs made by an open-source method to achieve efficient, transgene-free correction of monogenic disease mutations in patient-derived iPSCs. Our results provide an important proof of principle that ZFNs can be used to produce gene-corrected human iPSCs that could be used for therapeutic applications.