gebhart/patrepeval huggingface dataset:
The Flux OS Toolkit: reusable components for OS implementation (2002)

To an unappreciated degree, research both in operating systems (OSs) and their programming languages has been severely hampered by the lack of cleanly reusable code providing mundane low-level OS infrastructure such as bootstrap code and device drivers. The Flux OS Toolkit solves this problem by providing a set of clean, well-documented components. These components can be used as basic building blocks both for operating systems and for booting language run-time systems directly on the hardware. The toolkit's implementation itself embodies reuse techniques by incorporating components such as device drivers, file systems and networking code, unchanged, from other sources. We believe the kit also makes feasible the production of highly assured embedded and operating systems: by enabling reuse of low-level code, the high cost of detailed verification of that code can be amortized over many systems for critical environments. The OS toolkit is already heavily used in several different OS and programming language projects, and has already catalyzed research and development that would otherwise never have been attempted.
Growth regulation of mouse DNA methyltransferase gene expression (1991)

The steady state level of DNA methyltransferase mRNA is markedly increased as growth-arrested Balb/c 3T3 cells progress into the S phase of the cell cycle. mRNA abundance is reduced to the basal level before termination of DNA synthesis activity. Maintenance DNA methylation activity in nuclear extracts follows a similar pattern with two exceptions. (a) A small peak of DNA methylation activity is detected in early G1 phase. (b) The extinction of DNA methylation activity lags behind the termination of DNA synthesis. Nuclear runon experiments demonstrate that the gene is transcribed in growth-arrested cells, and expression of the gene is post-transcriptionally regulated. We suggest that this mode of regulation of the DNA methyltransferase gene might play an important role in determining and maintaining DNA methylation patterns.
Unconventional Multiple Fracture Treatments Using Dynamic Diversion and Downhole Mixing (2002)

Abstract This paper reviews a unique, relatively new stimulation process that uses dynamic fluid energy (instead of mechanical methods) to isolate treatment fluid flow to a specific fracture point along the wellbore. A process of hydrajet-fracturing has been developed by merging four existing technologies: hydrajetting, hydraulic fracturing, jet pump technology, and dual-path fluid injection. These have been meshed to create a method whereby a wellbore is perforated (if necessary) and a fracture is initiated and placed accurately at a specific location, and then soon repeated at another chosen location uphole, or closer to the heel when in a lateral wellbore. The process was later expanded as a hydrojet-squeeze stimulation method also, even to the point of applying both of these applications while stimulating a single wellbore. This process employs two independent fluid streams: one in the treating string and another in the annulus. As these fluid paths will be supplied with separate pumping equipment, we have the option to instantaneously alter the downhole mixture that is being used to treat the formation at the current location of the jetting tool. An additional use of this two-stream feature is the capability to pump two different fluids that can be mixed downhole with a tremendously high energy to form a homogenous mixture at the fracture entry point, even creating foamed fluids insitu for some applications. This technique has been used to stimulate more than 50 horizontal or highly deviated wells (and a few vertical wells) as of the preparation of this paper, both proppant-laden fractures and fracture acidizing treatments. On average, more than 7 fractures were placed along a typical horizontal wellbore, typically several hundred feet apart without the use of mechanical sealing equipment. Additionally, numerous horizontal wells with higher permeabilities have been stimulated using the hydrajet-squeeze process alone. The diversion process follows a dynamic isolation approach that uses a high-velocity, high-energy jetted fluid. The process was originally developed for its unique stimulation capabilities in openhole horizontal wells, but has been extended to wells that have cemented or non-cemented liners, whether vertical, deviated, or horizontal and even to multilateral completions (or recompletions). This paper offers insight into many of these treatments, including the different well situations, design considerations, operations, and available results of the treatments. Possible unconventional approaches using this concept and a unique implementation in the field are also discussed.
Phase II study of imatinib in patients with small cell lung cancer. (2003)

There was no observed antitumor activity in this limited Phase II trial of patients with SCLC, of which only a few tumors showed expression of the imatinib target. The results of this trial are, thus, inconclusive about the antitumor activity of imatinib against SCLC with the targeted KIT receptor (CD117). Further testing of imatinib in patients with SCLC will focus on demonstration of KIT expression in the setting of confirmed SCLC histology.
Electrolytic Corrosion of Gold and the Formation of Au2 (  SO 4 ) 3 in Concentrated Sulfuric Acid (1985)

Etude des reactions d'electrodes ayant lieu lors de l'electrolyse de l'or dans H 2 SO 4 concentre, afin de mieux comprendre les reactions chimiques. Oxydation anodique directe de l'or avec formation de soufre a la cathode et de O 3 et Au 2 (SO 4 ) 3 a l'anode. Formation d'or trivalent par corrosion electrolytique de l'or
The Immunophenotype of Adult Acute Myeloid Leukemia:High Frequency of Lymphoid Antigen Expression and Comparison of Immunophenotype, French-American-British Classification, and Karyotypic Abnormalities (1998)

Immunophenotyping has become common in the diagnosis and classification of acute leukemias and is particularly important in the proper identification of cases of minimally differentiated acute myeloid leukemia (AML-M0). To evaluate the immunophenotype of adult AML, 106 cases were studied by cytochemical analysis and by flow cytometry with a panel of 22 antibodies. The results were compared with the French-American-British (FAB) Cooperative Group classification, as well as with available cytogenetic data on each case. CD45, CD33, and CD13 were the most commonly expressed antigens (97.2%, 95.3%, and 94.3%, respectively). Lymphoid-associated antigens were expressed in 48.1% of cases. CD20 was the most commonly expressed lymphoid antigen (17%), although often expressed in only a subpopulation of leukemic cells, followed by CD7 (16%), CD19 (9.8%), CD2 (7.5%), CD3 (6.7%), CD5 (4.8%), and CD10 (2.9%). Some immunophenotypes correlated with FAB type, including increased frequency of CD2 expression in AML-M3; lack of CD4, CD11c, CD36, CD117, and HLA-DR expression in AML-M3; increased frequency of CD20 and CD36 expression and lack of CD34 expression in AML-M5; increased frequency of CD5 expression in AML-M5a; and increased frequency of CD14 expression in AML-M5b, when compared with all other AMLs (P < .05). When compared with AML-M5b, AML-M5a demonstrated a lack of CD4 expression and a high frequency of CD117 expression. Complete morphologic and cytogenetic agreement between AML-M3 and t(15;17) was present, and four of five cases of AML-M4Eo demonstrated inv(16). The remaining case of M4Eo was characterized by a 6;9 translocation, and two other inv(16) cases were not classified as M4Eo. Expression of CD2 was present in two t(15;17) cases and in one inv(16) case, but expression of this antigen was not restricted to AML cases with these karyotypic abnormalities. Similarly, expression of CD19 was not specific for t(8;21) AML. All t(8;21) leukemias demonstrated M2 morphology. With the exception of M3, M4Eo, and a subgroup of M2 leukemias, the FAB classification does not appear to define cytogenetically distinct disease groups in adult AML. Immunophenotypically distinct profiles were identified in the M3 and M5 morphologic groups of the FAB classification. Immunophenotyping studies are helpful in the determination of myeloid lineage. In general, however, they are not sufficiently specific alone to be useful in precisely identifying either FAB or cytogenetically defined disease subtypes.
Volume holographic data storage (2000)

article Free Access Share on Volume holographic data storage Author: Sergei S. Orlov Stanford Univ., Stanford, CA Stanford Univ., Stanford, CAView Profile Authors Info & Claims Communications of the ACMVolume 43Issue 11Nov. 2000 pp 46–54https://doi.org/10.1145/353360.353363Published:01 November 2000Publication History 13citation2,072DownloadsMetricsTotal Citations13Total Downloads2,072Last 12 Months93Last 6 weeks7 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteView all FormatsPDF
Inter-surface mapping (2004)

We consider the problem of creating a map between two arbitrary triangle meshes. Whereas previous approaches compose parametrizations over a simpler intermediate domain, we directly create and optimize a continuous map between the meshes. Map distortion is measured with a new symmetric metric, and is minimized during interleaved coarse-to-fine refinement of both meshes. By explicitly favoring low inter-surface distortion, we obtain maps that naturally align corresponding shape elements. Typically, the user need only specify a handful of feature correspondences for initial registration, and even these constraints can be removed during optimization. Our method robustly satisfies hard constraints if desired. Inter-surface mapping is shown using geometric and attribute morphs. Our general framework can also be applied to parametrize surfaces onto simplicial domains, such as coarse meshes (for semi-regular remeshing), and octahedron and toroidal domains (for geometry image remeshing). In these settings, we obtain better parametrizations than with previous specialized techniques, thanks to our fine-grain optimization.
Nucleotide sequence of HIV-2D194;, an isolate from a Gambian case of ‘Neuro-AIDS’, which showed excellent growth in macrophages (1990)

Journal Article Nucleotide sequence of HIV-2D194;, an isolate from a Gambian case of ‘Neuro-AIDS’, which showed excellent growth in macrophages Get access H. Kühnel, H. Kühnel * Chemotherapeutisches Forschungsinstitut Georg-Speyer-HausPaul-Ehrlich-Straβe 42–44, 6000 Frankfurt am Main 70, FRG *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Kreutz, R. Kreutz Chemotherapeutisches Forschungsinstitut Georg-Speyer-HausPaul-Ehrlich-Straβe 42–44, 6000 Frankfurt am Main 70, FRG Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Rübsamen-Waigmann H. Rübsamen-Waigmann Chemotherapeutisches Forschungsinstitut Georg-Speyer-HausPaul-Ehrlich-Straβe 42–44, 6000 Frankfurt am Main 70, FRG Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 18, Issue 20, 25 October 1990, Page 6142, https://doi.org/10.1093/nar/18.20.6142 Published: 25 October 1990 Article history Received: 28 August 1990 Published: 25 October 1990
CodY is required for nutritional repression of Bacillus subtilis genetic competence (1996)

The acquisition of genetic competence by Bacillus subtilis is repressed when the growth medium contains Casamino Acids. This repression was shown to be exerted at the level of expression from the promoters of the competence-regulatory genes srfA and comK and was relieved in strains carrying a null mutation in the codY gene. DNase I footprinting experiments showed that purified CodY binds directly to the srfA and comK promoter regions.
Tumor Cell Growth Arrest Caused by Subchromosomal Transferable DNA Fragments from Chromosome 11 (1993)

A fundamental problem in the identification and isolation of tumor suppressor and other growth-inhibiting genes is the loss of power of genetic complementation at the subchromosomal level. A direct genetic strategy was developed to isolate subchromosomal transferable fragments (STFs) from any chromosome, each containing a selectable marker within the human DNA, that could be transferred to any mammalian cell. As a test of the method, several overlapping STFs from 11p15 were shown to cause in vitro growth arrest of rhabdomyosarcoma cells. This activity mapped between the beta-globin and insulin genes.
Antineoplastic Mechanisms of Niclosamide in Acute Myelogenous Leukemia Stem Cells: Inactivation of the NF-κB Pathway and Generation of Reactive Oxygen Species (2010)

NF-kappaB may be a potential therapeutic target for acute myelogenous leukemia (AML) because NF-kappaB activation is found in primitive human AML blast cells. In this report, we initially discovered that the potent antineoplastic effect of niclosamide, a Food and Drug Administration-approved antihelminthic agent, was through inhibition of the NF-kappaB pathway in AML cells. Niclosamide inhibited the transcription and DNA binding of NF-kappaB. It blocked tumor necrosis factor-induced IkappaBalpha phosphorylation, translocation of p65, and expression of NF-kappaB-regulated genes. Niclosamide inhibited the steps TAK1-->IkappaB kinase (IKK) and IKK-->IkappaBalpha. Niclosamide also increased the levels of reactive oxygen species (ROS) in AML cells. Quenching ROS by the glutathione precursor N-acetylcysteine attenuated niclosamide-induced apoptosis. Our results together suggest that niclosamide inhibited the NF-kappaB pathway and increased ROS levels to induce apoptosis in AML cells. On translational study of the efficacy of niclosamide against AML, niclosamide killed progenitor/stem cells from AML patients but spared those from normal bone marrow. Niclosamide was synergistic with the frontline chemotherapeutic agents cytarabine, etoposide, and daunorubicin. It potently inhibited the growth of AML cells in vitro and in nude mice. Our results support further investigation of niclosamide in clinical trials of AML patients.
High resolution time-domain fluorescence lifetime imaging for biomedical applications (1999)

Abstract We report the development of a whole-field fluorescence lifetime imaging (FLIM) system with high temporal resolution based on a time-gated image intensifier. The optimized temporal gate width is < 100 ps, and changes in the environment of a fluorescent phantom, causing lifetime differences less than 10 ps, have been imaged. The versatility of this FLIM system has been demonstrated by measuring both the temporal and spectral profiles of multiple fluorescent samples in a single acquisition. Initial fluorescence lifetime images suggest that this technique can provide a means of distinguishing between different tissue constituents.
A Novel Lytic Peptide Composed of dl-Amino Acids Selectively Kills Cancer Cells in Culture and in Mice (2003)

The high toxicity of most chemotherapeutic drugs and their inactivation by multidrug resistance phenotypes motivated extensive search for drugs with new modes of action. We designed a short cationic diastereomeric peptide composed of d- and l-leucines, lysines, and arginines that has selective toxicity toward cancer cells and significantly inhibits lung metastasis formation in mice (86%) with no detectable side effects. Its ability to depolarize the transmembrane potential of cancer cells at the same rate (within minutes) and concentration (3 micro m), at which it shows biological activity, suggests a killing mechanism that involves plasma membrane perturbation. Confocal microscopy experiments verified that the cells died as a result of acute injury, swelling, and bursting, suggesting necrosis. Biosensor binding experiments and attenuated total reflectance-Fourier transform infrared spectroscopy using model membranes have substantiated its high selectivity toward cancer cells. Although this is an initial study that looked at tumor formation rather than the ability of the peptides to reduce established tumors, the simple sequence of the peptide, its high solubility, substantial resistance to degradation, and inactivation by serum components might make it a good candidate for future anticancer treatment.
Ribbons and groups: a thin rod theory for catheters and filaments (1999)

We use the rotation group and its algebra to provide a novel description of deformations of special Cosserat rods or thin rods that have negligible shear. Our treatment was motivated by the problem of the simulation of catheter navigation in a network of blood vessels, where this description is directly useful. In this context, we derive the Euler differential equations that characterize equilibrium configurations of stretch-free thin rods. We apply perturbation methods, used in time-dependent quantum theory, to the thin rod equations to describe incremental deformations of partially constrained rods. Further, our formalism leads naturally to a new and efficient finite element method valid for arbitrary deformations of thin rods with negligible stretch. Associated computational algorithms are developed and applied to the simulation of catheter motion inside an artery network.
Quantitative measure of .alpha.-silyl carbanion stabilization. The electron affinity of (trimethylsilyl)methyl radical (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitative measure of .alpha.-silyl carbanion stabilization. The electron affinity of (trimethylsilyl)methyl radicalDonna M. Wetzel and John I. BraumanCite this: J. Am. Chem. Soc. 1988, 110, 25, 8333–8336Publication Date (Print):December 1, 1988Publication History Published online1 May 2002Published inissue 1 December 1988https://pubs.acs.org/doi/10.1021/ja00233a008https://doi.org/10.1021/ja00233a008research-articleACS PublicationsRequest reuse permissionsArticle Views759Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hepatic Expression Patterns of Inflammatory and Immune Response Genes Associated with Obesity and NASH in Morbidly Obese Patients (2010)

The liver of obese patients without histological abnormalities already displayed a low-grade inflammation and could be more responsive to activators of the TLR pathway. NASH was then characterized by a specific gene signature. These findings help to identify new potential actors of the pathogenesis of NAFLD.
Automatic determination of scene changes in MPEG compressed video (2002)

This paper presents a peak-detection algorithm based on the median filter. When used with difference or correlation measures between contiguous video frames, this algorithm can determine significant peaks at "abrupt scene changes" in MPEG compressed video. Experimental data shows the algorithm is effective even for video with significant motion or sudden light changes such as in action movies, or sports video.
Thermodynamics and kinetics of adsorption of Cu(II) from aqueous solutions onto multi-walled carbon nanotubes (2011)

Release of heavy metals into water as a result of industrial activities may pose a serious threat to the environment. The objective of this study is to assess the uptake of Cu2+ from aqueous solutions onto multi-walled carbon nanotubes (MWCNT). The potential of the t-MWCNT to remove Cu2+ cations from aqueous solutions was investigated in batch reactor under different experimental conditions. The processing parameters such as initial concentration of Cu2+ ions, temperature, and adsorbent mass were also investigated. Copper uptake was quantitatively evaluated using the Langmuir, Freundlich and Dubinin–Kaganer–Radushkevich (DKR) models. In addition, the adsorption equilibrium was described well by the Langmuir isotherm model with maximum adsorption capacity of 12.34 mg/g of Cu2+ cations on t-MWCNT. Various thermodynamic parameters, such as ΔG0, ΔH0 and ΔS0 were calculated. The thermodynamics of Cu2+ cations adsorption onto t-MWCNT system pointed at spontaneous and endothermic nature of the process. Using the second-order kinetic constants, the activation energy of adsorption (Ea) was determined as 27.187 kJ/mol according to the Arrhenius equation.
The load, capacity and availability of quorum systems (2002)

A quorum system is a collection of sets (quorums) every two of which have a nonempty intersection. Quorum systems have been used for a number of applications in the area of distributed systems. We investigate the load, capacity and availability of quorum systems. We present four novel constructions of quorum system, all featuring optimal or near optimal load, and high availability. These desirable properties of the constructions translate into improvements of any protocol using them: a low work load on the processors and a high resilience to processor failures. The best construction, based on paths in a grid, has a load of O(1//spl radic/n), and a failure probability of exp(-O(/spl radic/n)) when the elements fail with probability p< 1/2 . Moreover, even in the presence of faults, with exponentially high probability the load of this system is still O(1//spl radic/n). The analysis of this scheme is based on Percolation Theory.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Dextromethorphan attenuates and reverses analgesic tolerance to morphine (1994)

Tolerance to the antinociceptive (analgesic) effect of morphine, a mu-opioid agonist, was developed in male CD-1 mice as assessed by a shift to the right of the analgesic (tail-flick) dose-response curves and an increase in the ED50 values. Administration of dextromethorphan at 30 mg/kg s.c., but not saline, 30 min prior to an escalating 3 times per day (t.i.d.) morphine dosing schedule prevented a 5-fold increase in the morphine ED50 value observed on treatment day 4. Concurrent administration of dextromethorphan at 12 mg/kg/24 h by s.c. infusion prevented the 6-fold increase in the morphine ED50 value that was observed in control mice that received morphine at 30 mg/kg/24 h by s.c. infusion. Implantation of two 25 mg morphine pellets resulted in a 10-fold increase in the morphine ED50 value on treatment day 4. Administration of dextromethorphan at 30 mg/kg s.c. t.i.d., but not saline, resulted in a reversal of morphine tolerance with the almost complete return of the morphine ED50 value to the control (opioid naive) value. These results demonstrate that dextromethorphan, an NMDA receptor antagonist can modulate morphine (mu-receptor)-mediated tolerance.