gebhart/patrepeval huggingface dataset:
P3–125: Fat intake at midlife and cognitive impairment later in life: A population–based study (2006)

Lifestyle and vascular factors have been linked to cognitive decline and dementia, but the role of dietary fats for cognitive impairment is less clear. To investigate the association of midlife dietary fat intake to cognitive performance, and to the occurrence of clinical mild cognitive impairment (MCI) later in life in a non–demented population. Participants of the Cardiovascular risk factors, Aging and the Incidence of DEmentia (CAIDE) study (n=1409) were derived from random, population–based samples studied in midlife and re–examined in late–life (follow–up of 20.9 years). A wide variety of cognitive tests were conducted for assessing global cognitive function, episodic, semantic and prospective memory, psychomotor speed, and executive function. Altogether 82 (5.8%) subjects were diagnosed as having clinical MCI. The demented subjects (n=68) were excluded from the current analyses. Dietary information was collected with a structured questionnaire and an interview. Logistic regression analyses were used to calculate associations between dietary fat intake and the risk of clinical MCI. To analyze the effect of fat intake on cognition, analyses of covariance (ANCOVA) were applied in multivariate models. Abundant saturated fat (SFA) intake from milk products and spreads at midlife was associated with poorer global cognitive function and prospective memory and with an increased risk of clinical MCI (OR 2.36, 95% CI 1.17–4.74) after adjusting for demographic and vascular factors, other fats and ApoE. On the contrary, higher intake of polyunsaturated fatty acids (PUFA) was associated with better semantic memory. Also frequent fish consumption was associated with better global cognitive function and semantic memory. Further, higher PUFA–SFA ratio was associated with better psychomotor speed and executive function. Our data suggests that dietary fat intake at midlife affects cognitive performance and the occurrence of clinical MCI in late–life. Thus, dietary interventions may modify cognitive performance and the risk of clinical MCI.
Oligoamines as simple and efficient catalysts for RNA hydrolysis (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOligoamines as simple and efficient catalysts for RNA hydrolysisKoichi Yoshinari, Katsutoshi Yamazaki, and Makoto KomiyamaCite this: J. Am. Chem. Soc. 1991, 113, 15, 5899–5901Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/ja00015a075https://doi.org/10.1021/ja00015a075research-articleACS PublicationsRequest reuse permissionsArticle Views240Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Recruitment of Uterine NK Cells: Induction of CXC Chemokine Ligands 10 and 11 in Human Endometrium by Estradiol and Progesterone (2004)

Uterine NK (uNK) cells express a unique set of markers compared with blood NK cells. However, recent studies suggest that uNK cells may be derived from the recruitment of blood NK cells into the endometrium. In this study, we used an in vitro organ culture system to demonstrate that estradiol induces expression of chemokines CXCL10 and/or CXCL11 within human endometrium in 85% of patient samples tested. The average increase in gene expression after 10(-9) M estradiol treatment was 8.5-fold for CXCL10 and 7.7-fold for CXCL11 compared with medium alone. We observed that a specific estrogen receptor antagonist (ICI182780) was able to prevent chemokine gene induction, indicating that the effect of estradiol was receptor mediated. Moreover, our study showed that progesterone induced CXCL10 and CXCL11 expression in 83% of endometrial samples tested. We have also found that uNK cells and blood NK cells express the receptor for CXCL10 and CXCL11, CXCR3, with the highest expression found on uNK cells and CD56(bright) blood NK cells. These data indicate that sex hormones induce specific chemokines in nonpregnant human endometrium that can activate NK cell migration, and suggest that this mechanism may account for the increased NK cell numbers in endometrium during the menstrual cycle.
<title>Electron trapping: a new approach to rewritable optical data storage</title> (1990)

A new approach to rewritable optical data storage is under development which has the potential for satisfying all of the key requirements for a dynamic on-line data storage system including removability, high data density, high speed and long cycle life. The approach utilizes an electron-trapping (ETTM) storage media consisting of alkaline earth crystals doped with rare-earth elements. Thin crystalline films of these media deposited on disk substrates can store information in the form of trapped electrons. The information is written, read, and erased entirely.
Control of the Kistler K-1 first stage reorientation prior to entry (1999)

The control design for the Kistler K1 First Stage reorientation maneuver is presented. The reorientation maneuver follows the main engine burn that places the first stage on a trajectory to return it to the landing site. The design takes advantage of the available aerodynamic moment to accelerate the first stage in the direction of the desired orientation for entry. The maneuver takes place near the apex of the first stage return trajectory, a region of low dynamic pressure. Small Attitude Control System (ACS) thrusters are used to stabilize the vehicle during the maneuver. The maneuver must therefore, complete prior to re-entry. This paper also presents a method for incorporating this time constraint into the design.
Highly nonlinear fiber with dispersive characteristic invariant to fabrication fluctuations (2012)

New class of highly nonlinear fibers possessing dispersive characteristics invariant to transverse geometry fluctuations is described. The sensitivity to stochastic core fluctuations is reduced by order of magnitude while maintaining the fiber nonlinear coefficient. The effectiveness of the new highly nonlinear fiber type is demonstrated on stochastically perturbed distant-band mixer that could not be previously constructed with high-confinement fiber. The new fiber design offers a unique platform for ideally phase matched parametric exchange with significantly increased Brillouin threshold.
Nota Bene: Pain-Killer Genes (1999)

Traumatic injuries are often followed by chronic nerve pain that remains long after the original injury has healed. Drugs to treat such neuropathic pain are often ineffective and can be associated with severe side effects. Wilson (1), Iadarola (2), and their colleagues now report two similar strategies for treating chronic pain, using viruses to deliver genes encoding pain-killer proteins to the central nervous system. Unlike analgesic drugs that are administered systemically, targeted delivery of a therapeutic pain-killer gene ensures that its protein product will be secreted in the vicinity of the nerves that conduct pain impulses.
Electroless deposition and characterization of Fe/FeOx nanoparticles on porous carbon microspheres: structure and surface reactivity (2013)

There has been great interest in synthetic methods that yield supported iron and iron oxide nanoparticles in order to prevent aggregation and improve their transport properties, handling and surface reactivity. In this work we report on the use of electroless deposition methods for the synthesis of carbon-supported iron/iron-oxide (Fe/FeOx) nanoparticles. We have used carbon porous microspheres synthesized via ultraspray pyrolysis as carbon scaffolds for the nucleation and growth of iron nanoparticles. The reported electroless deposition approach results in composite Fe/FeOx/carbon microspheres of narrowly dispersed size. A combination of X-ray powder diffraction (XRD) and X-ray absorption spectroscopies (EXAFS and XANES) was used in order to determine the structure and composition of the Fe/FeOx/carbon microspheres. Microspheres were found to display (14 ± 1)% iron content (w/w), whereby (12 ± 3)% of iron atoms were present as metallic iron and the remaining as maghemite (Fe2O3). Finally, we show that the removal capacity of Fe/FeOx/carbon microspheres for Cr(VI) is (20 ± 2) mg g−1 and that the maximum surface density for Cr adsorbates is (60 ± 6) μg m−2, thus suggesting that these are promising materials for the removal of water pollutants from aqueous solution.
Person De-Identification in Videos (2011)

Advances in cameras and web technology have made it easy to capture and share large amounts of video data over to a large number of people. A large number of cameras oversee public and semi-public spaces today. These raise concerns on the unintentional and unwarranted invasion of the privacy of individuals caught in the videos. To address these concerns, automated methods to de-identify individuals in these videos are necessary. De-identification does not aim at destroying all information involving the individuals. Its ideal goals are to obscure the identity of the actor without obscuring the action. This paper outlines the scenarios in which de-identification is required and the issues brought out by those. We also present an approach to de-identify individuals from videos. Our approach involves tracking and segmenting individuals in a conservative voxel space involving x, y , and time. A de-identification transformation is applied per frame using these voxels to obscure the identity. Face, silhouette, gait, and other characteristics need to be obscured, ideally. We show results of our scheme on a number of videos and for several variations of the transformations. We present the results of applying algorithmic identification on the transformed videos. We also present the results of a user-study to evaluate how well humans can identify individuals from the transformed videos.
Anti-VEGF single-chain antibody GLAF-1 encoded by oncolytic vaccinia virus significantly enhances antitumor therapy (2009)

We previously reported that the replication-competent vaccinia virus (VACV) GLV-1h68 shows remarkable oncolytic activity and efficacy in different animal models as a single treatment modality and also in combination with chemotherapy [Yu YA, et al. (2009) Mol Cancer Ther 8:141-151]. Here, we report the construction of 3 VACV strains encoding GLAF-1, a previously undescribed engineered single-chain antibody (scAb). This unique scAb is transcribed from 3 vaccinia promoters (synthetic early, early/late, and late) and directed against both human and murine VEGFs. The expression of GLAF-1 was demonstrated in cell cultures. Also, the replication efficiency of all GLAF-1-expressing VACV strains in cell culture was similar to that of the parental GLV-1h68 virus. Successful tumor-specific delivery and continued production of functional scAb derived from individual VACV strains were obtained in tumor xenografts following a single intravenous injection of the virus. The VACV strains expressing the scAb exhibited significantly enhanced therapeutic efficacy in comparison to treatment of human tumor xenografts with the parental virus GLV-1h68. This enhanced efficacy was comparable to the concomitant treatment of tumors with a one-time i.v. injection of GLV-1h68 and multiple i.p. injections of Avastin. Taken together, the VACV-mediated delivery and production of immunotherapeutic anti-VEGF scAb in colonized tumors may open the way for a unique therapy concept: tumor-specific, locally amplified drug therapy in humans.
Polyfunctional T cell responses are a hallmark of HIV‐2 infection (2008)

HIV-2 is distinguished clinically and immunologically from HIV-1 infection by delayed disease progression and maintenance of HIV-specific CD4(+) T cell help in most infected subjects. Thus, HIV-2 provides a unique natural human model in which to investigate correlates of immune protection against HIV disease progression. Here, we report a detailed assessment of the HIV-2-specific CD4(+) and CD8(+) T cell response compared to HIV-1, using polychromatic flow cytometry to assess the quality of the HIV-specific T cell response by measuring IFN-gamma, IL-2, TNF-alpha, MIP-1beta, and CD107a mobilization (degranulation) simultaneously following Gag peptide stimulation. We find that HIV-2-specific CD4(+) and CD8(+) T cells are more polyfunctional that those specific for HIV-1 and that polyfunctional HIV-2-specific T cells produce more IFN-gamma and TNF-alpha on a per-cell basis than monofunctional T cells. Polyfunctional HIV-2-specific CD4(+) T cells were generally more differentiated and expressed CD57, while there was no association between function and phenotype in the CD8(+) T cell fraction. Polyfunctional HIV-specific T cell responses are a hallmark of non-progressive HIV-2 infection and may be related to good clinical outcome in this setting.
Ministries (1975)

The following list contains all holders of paid and political ministerial offices since 1900. It leaves out some office-holders, since various offices in the Royal Household have during the past century ceased to be political appointments. The list also omits some politicians with governmental posts, since various other offices such as the Church Estates Commissioners are at times filled by M.P.s who are not regarded as part of the Ministry. Assistant Government Whips were unpaid until the 1964 Parliament and are not listed until then. Parliamentary Private Secretaries are also unlisted.KeywordsFamily BusinessCivil AviationCoalition GovernmentLabour GovernmentConservative GovernmentThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
A Modular Fuel Cell, Modular DC-DC Converter Concept for High Performance and Enhanced Reliability (2007)

Fuel cell stacks produce a DC output with a 2:1 variation in output voltage from no load to full load. The output voltage of each fuel cell is about 0.4 V at full load and several of them are connected in series to construct a stack. An example 100 V fuel cell stack consists of 250 cells in series and to produce 300 V at full load requires 750 cells stacked in series. Since fuel cells actively convert the supplied fuel to electricity, each cell requires proper distribution of fuel, humidification, coupled with water/thermal management needs. With this added complexity stacking more cells in series decreases the reliability of the system. For example, in the presence of bad or mal-performing cell/cells in a stack, uneven heating coupled with variations in cell voltages may occur. Continuous operation under these conditions may not be possible or the overall stack output power is severely limited. In this paper a modular fuel cell powered by a modular DC-DC converter is proposed. The proposed concept electrically divides the fuel cell stack into various sections, each powered by a DC-DC converter. The proposed modular fuel cell powered by modular DC-DC converter eliminates many of these disadvantages, resulting in a fault tolerant system. A design example is presented for a 150 W, three section fuel cell stack and DC-DC converter topology. Experimental results obtained on a 150 W, three section PEM fuel cell stack powered by a modular DC-DC converter are discussed.
Hematopoietic stem cell fate is established by the Notch–Runx pathway (2005)

Identifying the molecular pathways regulating hematopoietic stem cell (HSC) specification, self-renewal, and expansion remains a fundamental goal of both basic and clinical biology. Here, we analyzed the effects of Notch signaling on HSC number during zebrafish development and adulthood, defining a critical pathway for stem cell specification. The Notch signaling mutant mind bomb displays normal embryonic hematopoiesis but fails to specify adult HSCs. Surprisingly, transient Notch activation during embryogenesis via an inducible transgenic system led to a Runx1-dependent expansion of HSCs in the aorta-gonad-mesonephros (AGM) region. In irradiated adults, Notch activity induced runx1 gene expression and increased multilineage hematopoietic precursor cells approximately threefold in the marrow. This increase was followed by the accelerated recovery of all the mature blood cell lineages. These data define the Notch-Runx pathway as critical for the developmental specification of HSC fate and the subsequent homeostasis of HSC number, thus providing a mechanism for amplifying stem cells in vivo.
Citron, a Rho-Target, Interacts with PSD-95/SAP-90 at Glutamatergic Synapses in the Thalamus (1999)

Proteins of the membrane-associated guanylate kinase family play an important role in the anchoring and clustering of neurotransmitter receptors in the postsynaptic density (PSD) at many central synapses. However, relatively little is known about how these multifunctional scaffold proteins might provide a privileged site for activity- and cell type-dependent specification of the postsynaptic signaling machinery. Rho signaling pathway has classically been implicated in mechanisms of axonal outgrowth, dendrogenesis, and cell migration during neural development, but its contribution remains unclear at the synapses in the mature CNS. Here, we present evidence that Citron, a Rho-effector in the brain, is enriched in the PSD fraction and interacts with PSD-95/synapse-associated protein (SAP)-90 both in vivo and in vitro. Citron colocalization with PSD-95 occurred, not exclusively but certainly, at glutamatergic synapses in a limited set of neurons, such as the thalamic excitatory neurons; Citron expression, however, could not be detected in the principal neurons of the hippocampus and the cerebellum in the adult mouse brain. In a heterologous system, Citron was shown to form a heteromeric complex not only with PSD-95 but also with NMDA receptors. Thus, Citron-PSD-95/SAP-90 interaction may provide a region- and cell type-specific link between the Rho signaling cascade and the synaptic NMDA receptor complex.
Applied Nonlinear Control (1991)

Covers in a progressive fashion a number of analysis tools and design techniques directly applicable to nonlinear control problems in high performance systems (in aerospace, robotics and automotive areas).
Non-Alzheimer's Disease Dementias: Anatomic, Clinical, and Molecular Correlates (2004)

The unique cognitive and behavioural manifestations of the non-AD dementias can be mistaken for psychiatric disorders. Improved detection of tauopathies and synucleinopathies and their differentiation from AD is possible.
A newTaqlBO variant detected with the p49 probe on the human Y chromosome (1988)

Journal Article A new Taql BO variant detected with the p49 probe on the human Y chromosome Get access Patrick Guérin, Patrick Guérin Laboratory of Molecular GeneticsINTS, 6 rue Alexandre Cabanel, Paris 15ème, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Philippe Rouger, Philippe Rouger Laboratory of Molecular GeneticsINTS, 6 rue Alexandre Cabanel, Paris 15ème, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Gérard Lucotte Gérard Lucotte * Laboratory of Molecular GeneticsINTS, 6 rue Alexandre Cabanel, Paris 15ème, France *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 15, 11 August 1988, Page 7759, https://doi.org/10.1093/nar/16.15.7759 Published: 11 August 1988
CRYSTAL STRUCTURE OF THE SH3 DOMAIN IN HUMAN FYN; COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF SH3 DOMAINS IN TYROSINE KINASES AND SPECTRIN (1993)

The Src-homology 3 (SH3) region is a protein domain consisting of approximately 60 residues. It occurs in a large number of eukaryotic proteins involved in signal transduction, cell polarization and membrane--cytoskeleton interactions. The function is unknown, but it is probably involved in specific protein--protein interactions. Here we report the crystal structure of the SH3 domain of Fyn (a Src family tyrosine kinase) at 1.9 A resolution. The crystals have two SH3 molecules per asymmetric unit. These two Fyn SH3 domains are not related by a local twofold axis. The crystal structures of spectrin and Fyn SH3 domains as well as the solution structure of the Src SH3 domain show that these all have the same basic fold. A protein domain which has the same topology as SH3 is present in the prokaryotic regulatory enzyme BirA. The comparison between the crystal structures of Fyn and spectrin SH3 domains shows that a conserved surface patch, consisting mainly of aromatic residues, is flanked by two hairpin-like loops (residues 94-104 and 114-118 in Fyn). These loops are different in tyrosine kinase and spectrin SH3 domains. They could modulate the binding properties of the aromatic surface.
Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: basis for radiosensitivity of white spotting and steel mutant mice. (1994)

The receptor tyrosine kinase Kit and its cognate ligand KL/steel factor are encoded at the white spotting (W) and Steel (Sl) loci of the mouse, respectively. Mutations at both the W and the Sl loci affect hematopoiesis including the stem cell hierarchy, erythropoiesis, and mast cells, as well as gametogenesis and melanogenesis. In addition, mutant mice display an increased sensitivity to lethal doses of irradiation. The role of KL/c-kit in cell proliferation and survival under conditions of growth factor-deprivation and gamma-irradiation was studied by using bone marrow-derived mast cells (BMMC) as a model. Whereas apoptosis induced by growth factor deprivation in BMMC is a stochastic process and follows zero order kinetics, gamma-irradiation-induced apoptosis is an inductive process and follows higher order kinetics. In agreement with these results, gamma-irradiation-induced apoptosis in BMMC was shown to be dependent on p53 whereas apoptosis induced by deprivation is partly dependent on p53, implying that there are other mechanisms mediating apoptosis in KL-deprived BMMC. In the presence and in the absence of serum, KL stimulated proliferation by promoting cell cycle progression. The presence of KL was required only during the early part of the G1 phase for entry into the S phase. At concentrations lower than those required for proliferation, KL suppressed apoptosis induced by both growth factor-deprivation and gamma-irradiation, and internucleosomal DNA fragmentation characteristic of apoptosis. The ability of KL to suppress apoptosis was independent of the phase of the cell cycle in which the cells were irradiated and suppression of apoptosis was a prerequisite for subsequent cell cycle progression. Moreover, addition of KL to gamma-irradiated and growth factor-deprived cells could be delayed for up to 1 h after irradiation or removal of growth factors when cells became irreversibly committed to apoptosis. KL and IL-3 induce suppression of apoptosis in mast cells by different mechanisms based on the observations of induction of bcl-2 gene expression by IL-3 but not by KL. It is proposed that the increased sensitivity of W and Sl mutant mice to lethal irradiation results from paucity of the apoptosis suppressing and proliferative effects of KL.