gebhart/patrepeval huggingface dataset:
Anti-inflammatory effects of electronic signal treatment. (2009)

Inflammation often plays a key role in the perpetuation of pain. Chronic inflammatory conditions (e.g. osteoarthritis, immune system dysfunction, micro-circulatory disease, painful neuritis, and even heart disease) have increased as baby boomers age. Medicine's current anti-inflammatory choices are NSAIDs and steroids; the value in promoting cure and side effect risks of these medications are unclear and controversial, especially considering individual patient variations. Electricity has continuously been a powerful tool in medicine for thousands of years. All medical professionals are, to some degree, aware of electrotherapy; those who directly use electricity for treatment know of its anti-inflammatory effects. Electronic signal treatment (EST), as an extension of presently available technology, may reasonably have even more anti-inflammatory effects. EST is a digitally produced alternating current sinusoidal electronic signal with associated harmonics to produce theoretically reasonable and/or scientifically documented physiological effects when applied to the human body. These signals are produced by advanced electronics not possible even 10 to 15 years ago. The potential long-lasting anti-inflammatory effects of some electrical currents are based on basic physical and biochemical facts listed in the text below, namely that of stimulating and signaling effective and long-lasting anti-inflammatory effects in nerve and muscle cells. The safety of electrotherapeutic treatments in general and EST in particular has been established through extensive clinical use. The principles of physics have been largely de-emphasized in modern medicine in favor of chemistry. These electrical treatments, a familiar application of physics, thus represent powerful and appropriate elements of physicians' pain care armamentaria in the clinic and possibly for prescription for use at home to improve overall patient care and maintenance of quality of life via low-risk and potentially curative treatments.
An introduction to latent semantic analysis (1998)

Latent Semantic Analysis (LSA) is a theory and method for extracting and representing the contextual‐usage meaning of words by statistical computations applied to a large corpus of text (Landauer & Dumais, 1997). The underlying idea is that the aggregate of all the word contexts in which a given word does and does not appear provides a set of mutual constraints that largely determines the similarity of meaning of words and sets of words to each other. The adequacy of LSA's reflection of human knowledge has been established in a variety of ways. For example, its scores overlap those of humans on standard vocabulary and subject matter tests; it mimics human word sorting and category judgments; it simulates word‐word and passage‐word lexical priming data; and, as reported in 3 following articles in this issue, it accurately estimates passage coherence, learnability of passages by individual students, and the quality and quantity of knowledge contained in an essay.
Unsupervised Learning of Overlapping Image Components Using Divisive Input Modulation (2009)

This paper demonstrates that nonnegative matrix factorisation is mathematically related to a class of neural networks that employ negative feedback as a mechanism of competition. This observation inspires a novel learning algorithm which we call Divisive Input Modulation (DIM). The proposed algorithm provides a mathematically simple and computationally efficient method for the unsupervised learning of image components, even in conditions where these elementary features overlap considerably. To test the proposed algorithm, a novel artificial task is introduced which is similar to the frequently-used bars problem but employs squares rather than bars to increase the degree of overlap between components. Using this task, we investigate how the proposed method performs on the parsing of artificial images composed of overlapping features, given the correct representation of the individual components; and secondly, we investigate how well it can learn the elementary components from artificial training images. We compare the performance of the proposed algorithm with its predecessors including variations on these algorithms that have produced state-of-the-art performance on the bars problem. The proposed algorithm is more successful than its predecessors in dealing with overlap and occlusion in the artificial task that has been used to assess performance.
Age‐related changes in skin barrier function – Quantitative evaluation of 150 female subjects (2012)

The protection against water loss and the prevention of substances and bacteria penetrating into the body rank as the most important functions of the skin. This so-called 'skin barrier function' is the natural frontier between the inner organism and the environment, and is primarily formed by the epidermis. An impairment of the skin barrier function is often found in diseased and damaged skin. An influence of ageing on skin barrier function is widely accepted, but has not been conclusively evaluated yet. Therefore, the aim of this clinical study was to assess the potential influence of ageing on skin barrier function, including transepidermal water loss (TEWL), stratum corneum hydration, sebum content and pH value. One hundred and fifty healthy women aged 18-80, divided into five age groups with 30 subjects each, were evaluated in this study. TEWL, hydration level, sebum secretion and pH value of hydro-lipid acid film were measured with worldwide acknowledged biophysical measuring methods at cheek, neck, décolleté, volar forearm and dorsum of hand. Whereas TEWL and stratum corneum hydration showed only very low correlation with subject's age, the sebum production decreased significantly with age, resulting in the lowest skin surface lipids levels measured in subjects older than 70 years. The highest skin surface pH was measured in subjects between 50 and 60 years, whereas the eldest age group had the lowest mean pH. The dorsum of the hand was the location with the highest TEWL and lowest stratum corneum hydration in all age groups. The results show that only some parameters related to skin barrier function are influenced by ageing. Whereas sebum production decreases significantly over lifetime and skin surface pH is significantly increased in menopausal woman, TEWL and stratum corneum hydration show only minor variations with ageing.
Targeted gene editing restores regulated CD40L function in X-linked hyper-IgM syndrome (2016)

Loss of CD40 ligand (CD40L) expression or function results in X-linked hyper-immunoglobulin (Ig)M syndrome (X-HIGM), characterized by recurrent infections due to impaired immunoglobulin class-switching and somatic hypermutation. Previous attempts using retroviral gene transfer to correct murine CD40L expression restored immune function; however, treated mice developed lymphoproliferative disease, likely due to viral-promoter-dependent constitutive CD40L expression. These observations highlight the importance of preserving endogenous gene regulation in order to safely correct this disorder. Here, we report efficient, on-target, homology-directed repair (HDR) editing of the CD40LG locus in primary human T cells using a combination of a transcription activator-like effector nuclease-induced double-strand break and a donor template delivered by recombinant adeno-associated virus. HDR-mediated insertion of a coding sequence (green fluorescent protein or CD40L) upstream of the translation start site within exon 1 allowed transgene expression to be regulated by endogenous CD40LG promoter/enhancer elements. Additionally, inclusion of the CD40LG 3'-untranslated region in the transgene preserved posttranscriptional regulation. Expression kinetics of the transgene paralleled that of endogenous CD40L in unedited T cells, both at rest and in response to T-cell stimulation. The use of this method to edit X-HIGM patient T cells restored normal expression of CD40L and CD40-murine IgG Fc fusion protein (CD40-muIg) binding, and rescued IgG class switching of naive B cells in vitro. These results demonstrate the feasibility of engineered nuclease-directed gene repair to restore endogenously regulated CD40L, and the potential for its use in T-cell therapy for X-HIGM syndrome.
Polarisation-insensitive 980/1550 nm wavelength(de)multiplexer using MMI couplers (1997)

A polarisation-insensitive planar 980/1550 nm wavelength (de)multiplexing coupler based on multimode interference (MMI) effects is presented. The device is useful for integration with rare-earth doped waveguide amplifiers and lasers. The waveguide parameters and, in particular, the coupler width are chosen to optimise the device performance and obtain polarisation-insensitivity.
Dexlansoprazole in the Treatment of Esophagitis and Gastroesophageal Reflux Disease (2010)

Dexlansoprazole provides another treatment option for the management of EE and symptoms of heartburn. Considering that the cost of dexlansoprazole is not favorable, further studies evaluating potential advantages over other agents are necessary to define the role of dexlansoprazole in the treatment of these conditions.
The Prostate as an Endocrine Gland (1989)

Preface. Introduction. Part I. ANDROGENIC STEROIDS. Dihydrotestosterone. Part II. OTHER PARACRINE-ACTIVE AGENTS. Vasoactive Intestinal Peptide (VIP) and the Prostate. Plasminogen Activators. Part III. AUTOCRINE SECRETIONS. Oncogenes and the Prostate. Selective Osteoblastic Mitogens Extracted from Human Prostate Tissues. Polyamines and the Prostate. Studies of Prolactin-Prostate Interactions: Receptors, Receptor Regulation, Membrane Fluidity and Prolactin Processing. Part IV. REMOTE-ACTING SECRETIONS. Dihydrotestosterone: Origins and Spheres of Influence. Significance of Prostatic Inhibin Peptide (PIP) Thyrotropin-Releasing Hormone in Pathophysiology of Prostate. Immunobiological Implications of Select Bioactive Molecules in the Prostate with a Known and Unknown Target. Part V. PROSTATOTROPHIC HORMONES. Prolactin. Epithelial-Stromal Interactions and Cell Death in the Prostate.
Role of lung fluid volume in growth and maturation of the fetal sheep lung. (1990)

We studied the effects of alterations in lung fluid volume on growth and maturation of the fetal lung. In a chronic fetal sheep preparation, right fetal lung volume was decreased by drainage of lung fluid while the volume of the left lung was expanded by mainstem bronchus ligation leading to lung fluid retention. After an experimental period of 25 d (from 105 to 129 d of gestation, term = 145 d), the right (deflated) lung was significantly hypoplastic and contained less DNA than the controls; 175.15 +/- 55.18 vs. 346.77 +/- 61.97 mg, respectively; P less than 0.001. In contrast, the left (expanded) lung was significantly hyperplastic and contained more DNA than the controls; 390.74 +/- 103.53 vs. 238.85 +/- 33.32 mg, respectively; P = 0.001. Biochemical indices of lung maturation, including total phospholipids, phosphatidylcholine, and disaturated phosphatidylcholine content expressed per unit of tissue DNA, were no different when comparing the hypoplastic, hyperplastic, and control lungs. These findings demonstrate that fetal lung cell multiplication is influenced by local distension with lung fluid, while the biochemical maturation of fetal lung surfactant is under systemic control.
Prevention of ocular inflammation by matrine, prednisolone, and cyclooxygenase and lipoxygenase inhibitors. (1991)

Lens protein-induced ocular inflammation in rabbits was used to study the action mechanism of some anti-inflammatory agents. Indomethacin, a cyclooxygenase inhibitor, markedly reduced PGE2 and PGF2 alpha in the iris and ciliary body at 2 h but PGE2 only at 4 h. REV 5901, a lipoxygenase inhibitor, only significantly reduced PGE2 levels in the ciliary body at 4 h. PGF2 alpha levels were not affected by REV 5901. When indomethacin and REV 5901 were combined, both PGE2 and PGF2 alpha were suppressed at 2 and 4 h in both iris and ciliary body. Neither matrine nor prednisolone produced significant effects on the levels of PGE2 and PGF2 alpha. However, prednisolone exhibited the greatest reduction in chemotaxis of leukocytes followed by REV 5901. Indomethacin, on the contrary, produced a significant increase in chemotaxis of leukocytes. Matrine produced a decrease in leukocyte counts but was not statistically significant. These results indicate that indomethacin is effective in the early phase of inflammation to reduce PG's production whereas prednisolone and REV 5901 were more effective in the late phase of inflammation. Combined use of REV 5901 and indomethacin could become a drug of choice for the treatment of ocular inflammation without inducing corticosteroidal side effects.
Laparoscopic common bile duct exploration and removal of stones from a tiny choledochus: a report of 148 cases (2009)

Objective To summarize the experience in removal of stones from a tiny choledochus by laparoscopic common bile duct exploration (LCBDE). Methods From October 1993 to July 2008, there were 148 cases of cholelithiasis in tiny choledochus that common bile duct diameter was equal to 0. 4-0.8 cm undergoing LCBDE, involving choledochotomy, choledochoscopic exploration, electro-hydralic lithothipsy, ureteral catheter through cystic duct remnant for drainage of bile duct, T-tube drainage, the primary closure of duct incision. Results The procedure was successful in 116 out of the 148 cases and it was shifted to duodenoscopic papillotomy during the course of laparoscopy in 32 cases. No cases were shifted to open CBD exploration. No cases had residual stones. Bile leakage was cured with patent drainage in 7 cases. Three patients had slight pancreatitis postoperatively. Two pa-tients had bile duct stenosis of primary closure of duct incision. No cases had perforation of intestine and bile duct, bleeding, severe pancreatitis and death postoperatively. Conclusion If patients are suit-able, LCBDE is safe and effective in the hands of skilled endoscopiests.

Key words: 
Common bile duct diseases; Laparoscopy; Cholelithiasis
Therapeutic Applications of Imino Sugars in Lysosomal Storage Disorders (2003)

The N-alkylated imino sugars have inhibitory activity against the first enzyme in the pathway for glucosylating sphingolipid in eukaryotic cells, ceramide-specific glucosyltransferase. A therapeutic approach termed 'substrate deprivation' or 'substrate reduction therapy' (SRT) aims to reduce biosynthetic capability in the cell to match the reduced lysosomal catalytic activity seen in lysosomal storage disorders. The use of N-alkylated imino sugars to establish this therapeutic strategy is described in cell culture and gene knockout mouse disease models. One imino sugar, N-butyl-DNJ (NB-DNJ) has been in clinical trials for type 1 Gaucher disease and has shown to be an effective therapy for this disorder.
Prognostic Factors and Outcome of Core Binding Factor Acute Myeloid Leukemia Patients With t(8;21) Differ From Those of Patients With inv(16): A Cancer and Leukemia Group B Study (2005)

When the prognostic impact of race, secondary cytogenetic abnormalities, sex, and response to salvage treatment is considered, t(8;21) and inv(16) AMLs seem to be distinct clinical entities and should be stratified and reported separately.
Transport Properties of the Human Cartilage Endplate in Relation to Its Composition and Calcification (1996)

The proteoglycans normally found in the endplate regulate movement of solutes into and out of the disc. It has been shown previously that removal of proteoglycans from the endplate accelerates the loss of proteoglycans from the nucleus. Hence, a major function of the cartilage endplate may be to prevent fragments of osmotically active proteoglycans from leaving the disc.
A Bit of Progress in Language Modeling Extended Version (2001)

1.1 Overview Language modeling is the art of determining the probability of a sequence of words. This is useful in a large variety of areas including speech recognition,
Learning to rank social update streams (2012)

As online social media further integrates deeper into our lives, we spend more time consuming social update streams that come from our online connections. Although social update streams provide a tremendous opportunity for us to access information on-the-fly, we often complain about its relevance. Some of us are flooded with a steady stream of information and simply cannot process it in full. Ranking the incoming content becomes the only solution for the overwhelmed users. For some others, in contrast, the incoming information stream is pretty weak, and they have to actively search for relevant information which is quite tedious. For these users, augmenting their incoming content flow with relevant information from outside their first-degree network would be a viable solution. In that case, the problem of relevance becomes even more prominent. In this paper, we start an open discussion on how to build effective systems for ranking social updates from a unique perspective of LinkedIn -- the largest professional network in the world. More specifically, we address this problem as an intersection of learning to rank, collaborative filtering, and clickthrough modeling, while leveraging ideas from information retrieval and recommender systems. We propose a novel probabilistic latent factor model with regressions on explicit features and compare it with a number of non-trivial baselines. In addition to demonstrating superior performance of our model, we shed some light on the nature of social updates on LinkedIn and how users interact with them, which might be applicable to social update streams in general.
Free jets in vacuum technologies (2001)

The interest in jets expanding into a vacuum or a low-density background is raised by the appearance of new technological methods and growing requirements of high technology development. The use of free jets for vacuum technology, including space applications, has a number of aspects. One of the important achievements of the previous investigations is an understanding of jet structures in a variety of gas dynamic conditions. The accumulated knowledge on radial expansion into a vacuum, on the expansion of jets behind axially symmetric and flat sonic, and supersonic nozzles into a vacuum and background from the literature can be used for approximate evaluations. At present, more detailed data can be obtained as the result of computational modeling by continuum and kinetic approaches. Modern gas dynamics has at its disposal effective theoretical methods that open wide possibilities for vacuum technology development. The present article reflects the accumulated knowledge on the structure of jets, calculation of jet parameters, and modern trends in the analysis of low density jets.
External compression increases forearm perfusion (2005)

Application of compression stockings to the lower extremities is a widely used therapeutic intervention to improve venous return, but there is little information about the effects of compression on local arterial perfusion. Therefore, we tested the hypothesis that a positive external pressure increases forearm perfusion. The relation of increasing external pressure induced by standardized compression to the arterial inflow and arterial flow reserve of the forearm was critically evaluated in a group of healthy young men (n = 9). Flow was measured with venous occlusion plethysmography after a 10-min application of six different stockings with compression pressure increasing from 13 to 23 mmHg. During compression, the arterial inflow increased significantly from 3.7 +/- 0.85 to 8.8 +/- 2.01 ml.min(-1).100 ml tissue(-1) (P < 0.001) and the arterial flow reserve increased from 17.7 +/- 4.7 to 28.3 +/- 7.0 ml.min(-1).100 ml tissue(-1). The flow increase was persistent after 3 h of constant application of external pressure and also during simultaneous low-intensity hand grip. Similar results obtained with occlusion plethysmography were seen with MRI. During the interventions, forearm temperature was unchanged, and the volunteers reported no discomfort. In conclusion, 1) arterial perfusion of the human forearm increases more than twofold during application of external compression over a pressure range of 13-23 mmHg, and 2) the result is interpreted as an autoregulatory response following the decrease of the vascular transmural pressure gradient.
Novel 1,4‐diketo‐3,6‐diphenyl pyrrolo[3,4‐c]pyrrole (DPP)‐based copolymers with large Stokes shift (2008)

Abstract Two novel alternating π‐conjugated copolymers, named PDPPDOPV and PDPPDOPE, constituted of 1,4‐diketo‐3,6‐diphenyl pyrrolo[3,4‐c]pyrrole (DPP) with 2,5‐dioctyloxy‐1,4‐phenylenevinylene (DOPV) or 2,5‐dioctyloxy‐1,4‐phenyleneethynylene (DOPE), respectively, were synthesized and characterized by UV‐vis, FT‐IR, and photoluminescence spectroscopy. They are dark red solid readily soluble in various common organic solvents including THF and chloroform. The UV‐vis absorption spectra of the polymers show strong absorption bands, which correspond to the π‐π* transition of π‐conjugated segments. Photoluminescence (PL) spectra show that both polymer films and solution have large Stokes shifts. From their fluorescence behavior, Stokes shifts of 173 nm and 199 nm are derived for the films of PDPPDOPV and PDPPDOPE, respectively, which are the largest two values ever reported for DPP‐containing polymers. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Immersion lithography at 157 nm (2001)

We present a preliminary study on the feasibility of immersion lithography at 157 nm for patterning below 70 nm. This technology can enable an enhancement in resolution of ∼40% without radical changes in lasers, optics, or resist technology. We have identified a class of commercially available liquids, perfluoropolyethers, which are good candidates for use as immersion liquids. They are transparent (α≈10−3 μm−1 base 10), optically clean, chemically inert, and compatible with at least some current resist materials and with the semiconductor manufacturing environment. We have also constructed a high-resolution lensless interference immersion lithography system, preserving much of the design of a previous nonimmersion interference system. With this immersion interference tool, we have patterned resist with 30 nm dense features.
Analizador de redes eléctricas (2003)

El proyecto Analizador de redes electricas se encarga de medir la mayoria de los parametros de la potencia electrica, como son: armonicas de voltaje, corriente, potencia aparente, factor de potencia, potencia activa y distorsion armonica. Cuenta con un microcontrolador de la familia Microchip, el cual ya tiene integrado un convertidor analogo digital de 10 bits. La programacion se hace en lenguaje ensamblador para el muestreo del voltaje y la corriente y se envia en forma serial a una computadora en donde se realizan todos los calculos de los parametros de la energia electrica, el programa desarrollado es en lenguaje delphi.