gebhart/patrepeval huggingface dataset:
Polycythemia vera (1990)

<h3>CASE PRESENTATION</h3> —Peter White, Jr, MD A 64-YEAR-OLD retired truck driver was brought to The Johns Hopkins Hospital after a transient episode of unresponsiveness. Ten days before admission, when he entered another hospital for treatment of acute polyarticular gout, he appeared plethoric and had an enlarged spleen. The hematocrit was 0.71, red blood cell volume was 81 mL/kg (normal, 25 to 35 mL/kg), and plasma volume was 33 mL/kg (normal, 30 to 45 mL/kg). Bone marrow was hypercellular without fibrosis. He was treated for gout and polycythemia vera. Within a week 1200 mL of blood was withdrawn and he was discharged. On the following day, he was found to be unresponsive, with twitching movements of his hands and feet. The episode resolved within a few minutes, but he was promptly brought to the emergency department, where results of neurological examination and a cranial computed tomographic scan were normal. The patient
Differential Effects of Interleukin-1 Receptor Antagonist and Tumor Necrosis Factor Binding Protein on Fatty-Streak Formation in Apolipoprotein E–Deficient Mice (1998)

IL-1 plays a crucial role in the initial step of the atherosclerotic process in this animal model, and blocking the activity of this cytokine should be considered as a therapeutic possibility.
Block Copolymer Surface Reconstuction: A Reversible Route to Nanoporous Films (2003)

Abstract Thin films of block copolymers have been used as templates and scaffolds for the fabrication of arrays of nanostructured materials. In general, a chemical modification of the film or the removal of one of the components by photodegradative methods is required to produce a nanoporous film that serves as a template or scaffold. Here, however, the preferential interaction of one of the components with a solvent is shown to produce a reconstruction of the block copolymer film that, upon drying, leads to the generation of a nanoporous template. The area density of the pores is identical to that of the original copolymer thin film. Since no chemical reactions occurr, the process is fully reversible. Upon heating the copolymer film above its glass‐transition temperature, mobility is imparted to the copolymer and the original copolymer film with oriented domains is recovered. The film reconstruction significantly simplifies the generation of nanoporous templates.
Laser desorption/ionization time‐of‐flight mass spectrometry of squalene in oil samples (2005)

Letter to the Editor. No abstract available
Fas ligand‐induced murine pulmonary inflammation is reduced by a stable decoy receptor 3 analogue (2003)

Fas ligand (FasL)-induced lung inflammation has recently been suggested to play an important role in the pathogenesis of acute respiratory disease syndrome (ARDS). In order to further explore this connection, we established a FasL-induced murine model of pulmonary inflammation. Instillation of recombinant FasL (rFasL) into the lung induced neutrophil infiltration and increased pulmonary permeability, as evidenced by increased total protein in the airspace; both occur in patients with ARDS. These effects were accompanied with a rapid induction of proinflammatory mediators: cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) and the chemokines macrophage inflammatory protein-2 (MIP-2) and KC. Pretreatment with a FasL antagonist, a decoy receptor 3 analogue (DcR3 analogue), reduced neutrophil infiltration into the airspace and resulted in a highly significant reduction in the levels of GM-CSF, MIP-2 and KC in bronchoalveolar lavage (BAL) fluid. We postulate that rFasL may be responsible for induction of proinflammatory chemokines and cytokines in the lung, which in turn attract neutrophil infiltration into the airspace. This proinflammatory process and the associated pulmonary permeability may, in part, explain the association of FasL with severe pulmonary inflammation, such as ARDS, and shed new light on FasL and its role in lung injury.
Estimators for pairwise relatedness and individual inbreeding coefficients (1996)

Summary Method-of-moments estimators (MMEs) for the two-gene coefficients of relationship and inbreeding, and for thxe four-gene Cotterman coefficients, are described. These estimators, which use co-dominant genetic markers, are most appropriate for estimating pairwise relatedness or individual inbreeding coefficients, as opposed to their mean values in a group. This is because, compared to the maximum likelihood estimate (MLE), they show reduced small-sample bias and lack distributional assumptions. The ‘efficient’ MME is an optimally weighted average of estimates given by each allele at each locus. Generally, weights must be computed numerically, but if true coefficients are assumed zero, simplifiedestimators are obtained whose relative efficiencies are quite high. Population gene frequency is assumed to be assayed ina larger, ‘reference population’ sample, and the biases introduced by small reference samples and/or genetic drift of the reference population are discussed. Individual-level estimates of relatedness or inbreeding, while displaying high variance, are useful in several applications as a covariate in population studies.
Cross protection between a strain of Staphylococcus epidermidis and eight other species of coagulase-negative staphylococci (1988)

Passive protective activity of rabbit antiserum prepared by a representative capsular type II strain of Staphylococcus epidermidis in mice was absorbed out with homologous capsular type strains of S. simulans, S. cohnii, S. xylosus, S. hominis, S. capitis, S. hyicus, S. haemolyticus, and S. saprophyticus in addition to the homologous strain. The minimum amount of the strains required for absorption differed greatly, depending upon the strain. No absorption of the activity was shown with a strain of capsular type I and III of S. epidermidis, S. simulans, and S. cohnii, and a strain of capsular type III of S. hominis. These results suggest a possible capsular type specificity in the cross protection between strains of S. epidermidis and other species of coagulase-negative staphylococci.
Automatic Chinese food identification and quantity estimation (2012)

Computer-aided food identification and quantity estimation have caught more attention in recent years because of the growing concern of our health. The identification problem is usually defined as an image categorization or classification problem and several researches have been proposed. In this paper, we address the issues of feature descriptors in the food identification problem and introduce a preliminary approach for the quantity estimation using depth information. Sparse coding is utilized in the SIFT and Local binary pattern feature descriptors, and these features combined with gabor and color features are used to represent food items. A multi-label SVM classifier is trained for each feature, and these classifiers are combined with multi-class Adaboost algorithm. For evaluation, 50 categories of worldwide food are used, and each category contains 100 photographs from different sources, such as manually taken or from Internet web albums. An overall accuracy of 68.3% is achieved, and success at top-N candidates achieved 80.6%, 84.8%, and 90.9% accuracy accordingly when N equals 2, 3, and 5, thus making mobile application practical. The experimental results show that the proposed methods greatly improve the performance of original SIFT and LBP feature descriptors. On the other hand, for quantity estimation using depth information, a straight forward method is proposed for certain food, while transparent food ingredients such as pure water and cooked rice are temporarily excluded.
Linear filter analysis of methods for ultrashort-pulse-shape measurements (1995)

We analyze the properties required of a linear interferometer composed of time-stationary and time-nonstationary filters and a square-law, integrating detector in order that it may be used for the complete characterization of ultrashort optical pulses. Some general conditions for measurements are formulated for various schemes, and, in particular, time-nonstationary filtering is shown always to be necessary. The roles of both phase-only time nonstationarity and amplitude time gating are investigated in the context of known measurement schemes, and the known nonlinear schemes are shown to be members of a larger class of methods that use amplitude time-nonstationary filters.
In the light of directed evolution: Pathways of adaptive protein evolution (2009)

Directed evolution is a widely-used engineering strategy for improving the stabilities or biochemical functions of proteins by repeated rounds of mutation and selection. These experiments offer empirical lessons about how proteins evolve in the face of clearly-defined laboratory selection pressures. Directed evolution has revealed that single amino acid mutations can enhance properties such as catalytic activity or stability and that adaptation can often occur through pathways consisting of sequential beneficial mutations. When there are no single mutations that improve a particular protein property experiments always find a wealth of mutations that are neutral with respect to the laboratory-defined measure of fitness. These neutral mutations can open new adaptive pathways by at least 2 different mechanisms. Functionally-neutral mutations can enhance a protein's stability, thereby increasing its tolerance for subsequent functionally beneficial but destabilizing mutations. They can also lead to changes in "promiscuous" functions that are not currently under selective pressure, but can subsequently become the starting points for the adaptive evolution of new functions. These lessons about the coupling between adaptive and neutral protein evolution in the laboratory offer insight into the evolution of proteins in nature.
On-Line New Event Detection and Tracking (2017)

column Share on On-Line New Event Detection and Tracking Authors: James Allan University of Massachusetts, Amherst, MA University of Massachusetts, Amherst, MAView Profile , Ron Papka University of Massachusetts, Amherst, MA University of Massachusetts, Amherst, MAView Profile , Victor Lavrenko University of Massachusetts, Amherst, MA University of Massachusetts, Amherst, MAView Profile Authors Info & Claims ACM SIGIR ForumVolume 51Issue 2July 2017 pp 185–193https://doi.org/10.1145/3130348.3130366Published:02 August 2017Publication History 11citation192DownloadsMetricsTotal Citations11Total Downloads192Last 12 Months7Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Hemispatial neglect (2004)

The neglect syndrome per se, rather than overall stroke severity, predicts poor outcome in right hemisphere stroke. Dissociations between tasks assessing neglect subtypes support the existence of these subtypes. Finally, neglect results from lesions at various loci within a distributed system mediating several aspects of attention and spatiomotor performance.
Serum levels of the regulatory cytokines transforming growth factor-β and interleukin-10 are reduced in patients with discoid lupus erythematosus (2011)

T-lymphocytes are believed to play an important role in the pathogenesis of discoid lupus erythematosus (DLE). However, the reasons that lead to loss of tolerance and to development of autoimmunity in DLE remain unclear. In the present paper, we investigated serum levels of the regulatory cytokines transforming growth factor (TGF)-β and interleukin (IL)-10 in 25 newly diagnosed patients with DLE, 15 with systemic lupus erythematosus (SLE), 10 with psoriasis, 10 with atopic dermatitis (AD) and 20 healthy controls (HC). TGF-β serum levels were significantly lower in patients with DLE compared with patients with psoriasis and HC, while no differences were found between DLE, SLE and AD (medians: DLE: 28.49 ng/ml; psoriasis: 42.77 ng/ml; HC: 43.71 ng/ml; DLE vs. psoriasis: p < 0.05; DLE vs. HC: p < 0.05). IL-10 concentrations were reduced in DLE serum samples with respect to SLE, psoriasis, AD and HC (medians: DLE: 46.42 pg/ml; SLE: 127.64 pg/ml; psoriasis: 109.3 pg/ml; AD: 76.3 pg/ml; HC: 114.71 pg/ml; DLE vs. SLE: p < 0.05; DLE vs. psoriasis: p < 0.05; DLE vs. AD: p < 0.05; DLE vs. HC: p < 0.05). The downregulation of TGF-β and IL-10 in DLE may lead to defective immune suppression and thus to the generation of the tissue injury that is found in lupus patients.
pH dependence of the reversible and irreversible thermal denaturation of .gamma. interferons (1989)

Heated at pH 6.0 and at 50 degrees C, human interferon gamma (HuIFN-gamma) is inactivated via the formation of insoluble aggregates. At pH 6.0, the aggregation rate increases with temperature from 40 to 65 degrees C. There is a temperature-dependent time lag to aggregate formation observed in the generation of light-scattering particles at pH 6.0, and this correlates with the fast phase observed in the kinetics of reversible thermal unfolding. In addition, the dependence of aggregation kinetics on temperature closely follows the reversible melting curve. These observations suggest that at pH 6.0 irreversible thermal denaturation and aggregation depend on partial or complete unfolding of the molecule. At pH 5.0, also at 50 degrees C, the molecule is stable to irreversible aggregation. In reversible unfolding in 0.25 M guanidine hydrochloride, the Tm for HuIFN-gamma increases from 30.5 degrees C at pH 4.75 to 41.8 degrees C at pH 6.25, in analogy to the behavior of other globular proteins. These observations suggest that the relative instability of HuIFN-gamma to irreversible denaturation via aggregation at pH 6.0 compared to pH 5.0 is not due to an increased stability toward unfolding at the lower pH. Alternatively, stability at pH 5.0 must be due either to the improved solution properties of the unfolded state or to the improved solubility/decreased kinetic lifetime of an unfolding intermediate. Aggregation of HuIFN-gamma at 50 degrees C is half-maximal at pH 5.7, suggesting that protonation of one or both of the histidine residues may be involved in this stabilization.(ABSTRACT TRUNCATED AT 250 WORDS)
START: System Testability Analysis and Research Tool (2002)

A brief overview of the Systems Testability Analysis and Research Tool (START) software package for automatic test sequencing and testability analysis of complex hierarchically described modular systems is presented. It consists of algorithms based on information theory, heuristic search, and graph theory to solve various facets of the test sequencing and testability analysis problems. A system is modeled in the failure space as a hierarchical directed graph with nodes denoting modules and test points and AND nodes denoting redundancy. Interconnections among the nodes denote their immediate functional dependencies. START supports hierarchical testing in accordance with the maintenance strategy; a failure source may be isolated to a component or a module at any level, e.g. LRU (line replaceable unit), SRU (shop replaceable unit), etc. Other practical features include options to integrate diagnosis with repair (after partial diagnosis) and to optimize test time, test cost, or test and repair cost. An interactive menu-mouse graphical interface serves as a high-level front end to these algorithms and enables the user to graphically enter and modify hierarchical functional models of systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
RLSESN‐based PID adaptive control for a novel wearable rehabilitation robotic hand driven by PM‐TS actuators (2012)

Purpose The purpose of this paper is to develop a novel wearable rehabilitation robotic hand driven by Pneumatic Muscle‐Torsion Spring (PM‐TS) for finger therapy. PM has complex nonlinear dynamics, which makes PM modelling difficult. To realize high‐accurate tracking for the robotic hand, an Echo State Network (ESN)‐based PID adaptive controller is proposed, even though the plant model is unknown. Design/methodology/approach To drive a single joint of rehabilitation robotic hand, the paper proposes a new PM‐TS actuator comprising a Pneumatic Muscle (PM) and a Torsion Spring (TS). Based on the novel actuator, a wearable robotic hand is designed. By employing the model‐free approximation capability of ESN, the RLSESN based PID adaptive controller is presented for improving the trajectory tracking performance of the rehabilitation robotic hand. An ESN together with Recursive Least Square (RLS) is called a RLSESN, where the ESN output weight matrix is updated by the online RLS learning algorithm. Findings Practical experiments demonstrate the validity of the PM‐TS actuator and indicate that the performance of the RLSESN based PID adaptive controller is better than that of the conventional PID controller. In addition, they also verify the effectiveness of the proposed rehabilitation robotic hand. Originality/value A new PM‐TS actuator configuration that uses a PM and a torsion spring for bi‐directional movement of joint is presented. By utilizing the new PM‐TS actuator, a novel wearable rehabilitation robotic hand for finger therapy is designed. Based on the unknown plant model, the RLSESN_PID controller is proposed to attain satisfactory performance.
Intra-articular injections for osteoarthritis of the knee. (2006)

If usual medical measures fail to control the pain of knee osteoarthritis and allow the patient to cope with its symptoms, intra-articular injections of a corticosteroid, a hyaluronan, or both can be tried.
A newly designed anticancer tumor immunity drug delivery system. (1992)

The authors used a fibrin clot (FC) as a carrier of an anti-cancer drug (AD) to achieve sustained release of the drug. Adriamycin (ADM) and cis-platinum (CDDP) were individually encapsulated into an FC, and the profile of release of each AD from the FC-AD was examined in vitro. The FC-AD was placed intra-abdominally in ascites hepatoma AH130-bearing rats, and ADM or CDDP solution was intraperitoneally injected (IP) into other cancer bearing rats. The survival time was recorded, and related oncolytic mechanisms were investigated. The release of AD from the FC continued for over 15 days. Sixty-eight percent of the rats treated with FC-AD survived for more than 200 days and evidence of malignancy disappeared. Almost all of the IP rats and non-treated rats died within 20 days; these animals had massive ascites and extensive metastases. Immunologic studies confirmed that various tumor immunoresponses were induced in the rats treated with FC-AD. The FC-AD system warrants further study for possible antineoplastic activities in vivo.
Sleep and epileptic activity. (1991)

Thirteen patients suffering from severe partial epilepsy and potential candidates for surgical treatment were investigated with stereotactically implanted intracerebral electrodes during nocturnal physiological sleep. The recorded electrocerebral activity was automatically analyzed to gain information on interictal epileptic events during wakefulness and the phases of sleep. The interictal epileptic activity shows: (1) great variability in the different subjects, and intra-individually, variability according to the explored cerebral regions; (2) is not influenced by the location of the recorded epileptic events; and (3) is affected by the local level of epileptogenicity. The latter was determined by the assessment of the capacity to give origin to ictal discharges and the disappearance of seizures following surgical removal. The interictal rate of spiking from the most epileptogenic cerebral zone is characterized by a relative stability during the night and by a relatively high degree during REM sleep.
SLLP1, A Unique, Intra-acrosomal, Non-bacteriolytic, c Lysozyme-Like Protein of Human Spermatozoa1 (2003)

We report the presence of a unique, non-bacteriolytic, c (chicken or conventional type) lysozyme-like protein, SLLP1, in the acrosome of human sperm. C lysozymes are bacteriolytic and can also bind to N-acetylglucosamines linked by beta-1,4 glycosidic bonds. Most of the invariant residues (17 out of 20), including all the cysteines, were conserved in SLLP1, but the two catalytic residues E35 and D52 of c lysozymes were replaced with T and N, respectively. The full-length cDNA encodes a protein of 215 aa with a predicted protease cleavage site between A87 and K88. The processed form of SLLP1, which showed an exon-intron organization similar to human c lysozyme, was the major isoform in the acrosome of ejaculated sperm. As expected, based on its sequence, the mature protein secreted from yeast showed no bacteriolytic activity. A significant decrease (54%, P < or = 0.001) in the number of sperm bound to zona-free hamster eggs was observed in the presence of antisera to recombinant SLLP1. SLLP1 mRNA (size, approximately 1 kb) appeared to be expressed only in the testis and in the Burkitt lymphoma Raji cell line. The gene SPACA3 encodes SLLP1 and contains five exons at locus 17q11.2. Because of its typical c lysozyme-like sequence, genomic organization, conservation of putative substrate-binding sites even in the absence of catalytic residues, and localization in the acrosomal matrix, we hypothesize that, after acrosome reaction, SLLP1 could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane, within the perivitelline space, pores of zona pellucida, and cumulus layers.
Acute Fibrinolysis Shutdown after Injury Occurs Frequently and Increases Mortality: A Multicenter Evaluation of 2,540 Severely Injured Patients (2016)

Fibrinolysis shutdown is the most common phenotype on admission and is associated with increased mortality. These data provide additional evidence of distinct phenotypes of coagulation impairment and that individualized hemostatic therapy may be required.
Understanding the effects of leakage in superconducting quantum error detection circuits (2013)

The majority of quantum error detection and correction protocols assume that the population in a qubit does not leak outside of its computational subspace. For many existing approaches, however, the physical qubits do possess more than two energy levels and consequently are prone to such leakage events. Analyzing the effects of leakage is therefore essential to devise optimal protocols for quantum gates, measurement, and error correction. In this work, we present a detailed study of leakage in a two-qubit superconducting stabilizer measurement circuit. We simulate the repeated ancilla-assisted measurement of a single $σ^z$ operator for a data qubit, record the outcome at the end of each measurement cycle, and explore the signature of leakage events in the obtained readout statistics. An analytic model is also developed that closely approximates the results of our numerical simulations. We find that leakage leads to destructive features in the quantum error detection scheme, making additional hardware and software protocols necessary.
Frequency-bin entangled comb of photon pairs from a Silicon-on-Insulator micro-resonator (2011)

We present a quantum-mechanical theory to describe narrowband photon-pair generation via four-wave mixing in a Silicon-on-Insulator (SOI) micro-resonator. We also provide design principles for efficient photon-pair generation in an SOI micro-resonator through extensive numerical simulations. Microring cavities are shown to have a much wider dispersion-compensated frequency range than straight cavities. A microring with an inner radius of 8 μm can output an entangled photon comb of 21 pairwise-correlated peaks (42 comb lines) spanning from 1.3 μm to 1.8 μm. Such on-chip quantum photonic devices offer a path toward future integrated quantum photonics and quantum integrated circuits.