gebhart/patrepeval huggingface dataset:
miRNA in Circulating Microvesicles as Biomarkers for Age-Related Cognitive Decline (2017)

Community dwelling older individuals from the North Florida region were examined for health status and a comprehensive neuropsychological battery, including the Montreal Cognitive Assessment (MoCA), was performed on each participant. A subpopulation (58 females and 39 males) met the criteria for age (60-89) and no evidence of mild cognitive impairment, with a MoCA score ≥23. Despite the stringent criteria for participation, MoCA scores were negatively correlated within the limited age range. Extracellular microvesicles were isolated from the plasma and samples were found to be positive for the exosome marker CD63, with an enrichment of particles within the size range for exosomes. miRNA was extracted and examined using next generation sequencing with a stringent criterion (average of ≥10 counts per million reads) resulting in 117 miRNA for subsequent analysis. Characterization of expression confirmed pervious work concerning the relative abundance and overall pattern of expression of miRNA in plasma. Correlation analysis indicated that most of the miRNAs (74 miRNAs) were positively correlated with age (<i>p</i> <0.01). Multiple regression was employed to identify the relationship of miRNA expression and MoCA score, accounting for age. MoCA scores were negatively correlated with 13 miRNAs. The pattern of expression for cognition-related miRNA did not match that previously described for Alzheimer's disease. Enrichment analysis was employed to identify miRNA-gene interactions to reveal possible links to brain function.
Proposal for the Coma Aberration Dependent Overlay Error Compensation Technology (1998)

A new method for overlay accuracy improvement which compensates for the positional shifts of patterns due to coma aberrations, using the pattern placement error-corrected mask is proposed. Various types of resolution enhancement technologies such as modified illumination and phase shifting techniques significantly improve the resolution. The effects of residual aberrations in the lens system cannot be ignored because such resolution enhancement technologies emphasize the effects of the aberrations in the projected images. One of the key issues is the deterioration of the positional accuracy due to coma aberrations. As the positional shifts of patterns heavily depend on the spatial frequency of the pattern and the illumination conditions. 2.0-µm isolated line patterns and 0.3-µm line-and-space patterns are selected and their pattern shift examined. Two types of correction methods were investigated in this work using the pattern placement error-corrected mask, the absolute correction and the relative correction method. By the use of these correction methods, the overlay errors due to coma aberrations can be reduced to half of the error obtained without application of these correction methods.
Isolation, characterization, and serial propagation of a bovine group C rotavirus in a monkey kidney cell line (MA104) (1991)

A virus (designated the Shintoku strain) which was morphologically indistinguishable from group A rotaviruses was detected in the feces of adult cows with diarrhea in Japan. The virus contained 11 segments of double-stranded RNA and had an electrophoretic migration pattern in polyacrylamide gels similar to that of other group C rotaviruses (4-3-2-2). Feces containing the bovine virus reacted with antiserum to porcine group C rotavirus (Cowden strain) but not group A or B rotaviruses in immunoelectron microscopy. The virus was adapted to serial propagation in roller tube cultures of a rhesus monkey kidney cell line (MA104) by using high concentrations of trypsin. Evidence for viral replication in MA104 cell cultures was demonstrated by immunoelectron microscopy and indirect immunofluorescence by using antiserum to porcine group C rotavirus and by electrophoretic analysis of extracted viral double-stranded RNA. A significant antibody response against the isolate was detected in convalescent-phase sera of cows which excreted the virus: no increased antibody response to bovine group A rotavirus was observed. To our knowledge, this is the first isolation of a group C rotavirus from cattle.
Study on Aromatic Phosphines for Novel Fluorometry of Hydroperoxides (II) -The Determination of Lipid Hydroperoxides with Diphenyl-1-Pyrenylphosphine - (1987)

Abstract A new fluorometric determination of hydroperoxides was proposed. Non-fluorescent diphenyl-1-pyrenyl-phosphine (DPPP) was oxidized quantitatively by hydroperoxides to a strong fluorescent DPPP oxide. A sensitive assay for lipid hydroperoxides was developed based on the reaction. The reaction of lipid hydroperoxides with DPPP was conducted in the dark in the mixture of chloroform and methanol at 60°C within 60 min. The contents of hydroperoxides showed linear relation to the fluorescence intensities in a wide concentration range. The sensitivity was 10,000 times higher than conventional iodometry. The correlation constant between peroxide values obtained by iodometry and by this method was 0.9993 (n=10). The sample size was minimized to less than 3 mg per tube.
Nonablative neonatal marrow transplantation attenuates functional and physical defects of β-glucuronidase deficiency (2001)

The toxicity of preparative regimens render neonatal bone marrow transplantation (BMT) for progressive childhood diseases a controversial treatment. Ablative BMT in neonatal mice with or without the lysosomal storage disease mucopolysaccharidosis type VII (MPS VII) show high morbidity and developmental disruption of both brain and bone structure. In this investigation, BMT was performed with a high dose of congenic, normal bone marrow into nonablated newborn mice. Recipients had lifelong, multilineage, peripheral blood chimerism with the donor beta-glucuronidase-positive (GUS(+)) cells that was both well tolerated and therapeutic. Three daily injections of normal adult marrow increased the average life span by at least 6 months and corrected the functional breeding deficits typical of the MPS VII mice. Twelve months after injection, several structural features of femurs were more like that of normal mice than of untreated MPS VII mice. Periosteal circumference and bone cortical thickness were significantly improved in males and cortical density did not differ significantly from values in normal females. Significant reduction of lysosomal glycosaminoglycan storage corresponded directly with GUS enzyme activity and percentage of histochemically GUS(+) cells in visceral organs and hematopoietic tissues such as thymus, spleen, peripheral blood, and bone marrow. By all criteria tested, BMT into neonatal MPS VII mice in the absence of any preparative regimen is a successful therapy.
<title>Automatic generation of pictorial transcripts of video programs</title> (1995)

An automatic authoring system for the generation of pictorial transcripts of video programs which are accompanied by closed caption information is presented. A number of key frames, each of which represents the visual information in a segment of the video (i.e., a scene), are selected automatically by performing a content-based sampling of the video program. The textual information is recovered from the closed caption signal and is initially segmented based on its implied temporal relationship with the video segments. The text segmentation boundaries are then adjusted, based on lexical analysis and/or caption control information, to account for synchronization errors due to possible delays in the detection of scene boundaries or the transmission of the caption information. The closed caption text is further refined through linguistic processing for conversion to lower- case with correct capitalization. The key frames and the related text generate a compact multimedia presentation of the contents of the video program which lends itself to efficient storage and transmission. This compact representation can be viewed on a computer screen, or used to generate the input to a commercial text processing package to generate a printed version of the program.
The biologic effects of implant materials (1991)

Abstract The interaction between implant materials and the surrounding biological environment continues to be an area of intense research and clinical interest. This article presents the information presented in a symposium, held during the 36th Annual Meeting of the Orthopaedic Research Society, in which several important issues concerning the biologic effects of implant materials were discussed. These issues included the mechanisms by which implant materials are released to the surrounding tissues and the ways in which these tissues respond to implant materials. The problem of bone loss around cementless implants was discussed as a specific example of a biologic effect resulting in both bone remodelling and endosteal erosion.
Radiofrequency treatment of sacroiliac joint-related pain aimed at the first three sacral dorsal rami: a minimal approach (2004)

Abstract Background and objectives: The sacroiliac joint (SIJ) is a potential source of low back pain. Establishing the diagnosis of SIJ syndrome is difficult because there are no specific criteria to confirm this syndrome. SIJ-related pain can be treated by multiple intra-articular injections (with a local anesthetic combined with a long acting steroid) or with a radiofrequency (RF) denervation technique. Three RF techniques have already been described. In this paper the authors describe a new RF approach in denervating the SIJ under fluoroscopic guidance, with only 3 punctures, based on its innervation. Methods: Forty-three patients with a long history of low back pain and confirmed SIrelated SIJ pain were selected on basis of presence of tenderness over the SIJ region on palpation, elucidation of pain by provocation tests, and a temporary pain relief after intraarticular injection with local anesthetics. Results: We performed 49 procedures in 43 patients. After 12 weeks, 15 of the 49 RF SI procedures (34.9%) resulted in complete pain relief, while another 14 (32.6%) reported pain relief of 50% or more. This was respectively in 10 (26.3%) and 13 (34.2%) of the patients. One patient who was treated on both sides has complete relief on one side, and >50% pain relief at the other side. So, in total 63.2% claimed a 50% decrease of pain or more. One patient complained of increased pain. There were no other complications. Relatively more female patients reported pain relief after the treatment.Keywords: RADIOFREQUENCYSACROILIAC JOINTLOW BACK PAIN.
Primary structure of human alpha 2-antiplasmin, a serine protease inhibitor (serpin). (1987)

The plasma protein alpha 2-antiplasmin is the main physiological inhibitor of the serine protease plasmin, which is responsible for the dissolution of fibrin clots. We have determined the primary structure of mature human alpha 2-antiplasmin by DNA sequencing of overlapping cDNA fragments prepared from human liver mRNA. cDNA clones were identified by hybridization with a 48-base pair deoxyoligonucleotide probe deduced from the sequence of a 16-amino acid peptide of alpha 2-antiplasmin. Mature human alpha 2-antiplasmin contains 452 amino acids. It is homologous (23-28%) with five other proteins belonging to the serine protease inhibitor (serpin) superfamily. Its reactive site, i.e. the peptide bond cleaved by reaction with its primary target enzyme, plasmin, consists of Arg364-Met365. This dipeptide corresponds to the reactive site Met358-Ser359 of the archetypal serpin, alpha 1-antitrypsin.
Heterogeneity in opsonic requirements of Staphylococcus epidermidis: relative importance of surface hydrophobicity, capsules and slime. (1989)

The opsonic requirements of 65 strains of Staphylococcus epidermidis were compared in fresh and in heated normal human serum. The strains were isolated from patients with CAPD peritonitis (n = 26), neonatal septicaemia (n = 24) and nasal cultures (n = 15). A wide variation was observed in opsonic requirements between the different strains, both with fresh and with heated serum. Opsonization in heated serum proceeded less efficiently and higher concentrations (mean three-fold compared to fresh serum) were needed for adequate phagocytosis. However, a highly significant correlation was found between the minimal opsonic concentrations of fresh and of heated serum (r = 0.84, P less than 0.0005). In addition, S. epidermidis can become opsonized in agammaglobulinaemic serum. Thus, opsonization of S. epidermidis can be mediated by antibodies alone and by complement alone. Slime-producing strains and encapsulated strains did not require higher concentrations of serum to become opsonized. Opsonic requirements were highly significantly correlated with surface hydrophobicity. Enzymatic treatment rendered the strains more hydrophilic and decreased their opsonic requirements. Isolates from nasal cultures required significantly higher concentrations of both fresh and heated serum to become adequately phagocytozed, whereas isolates from CAPD peritonitis required higher concentrations of heated serum only compared to blood isolates. The uptake of S. epidermidis preopsonized in heated serum as determined in our direct phagocytosis assay did not result in a comparable chemiluminescence response.
Warm Compresses and the Risks of Elevated Corneal Temperature With Massage (2013)

These data show that WC use for lid warming, even when only minimal contact pressure is applied, also transfers significant heat to the cornea. Corneal temperatures reach peak temperature after about 8 minutes of WC application. Recent reports discussing the increased potential for transient and long-term corneal molding subsequent to the heat and pressure of WC application are briefly reviewed.
Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery (2015)

Roux-en-Y gastric bypass (RYGB) is highly effective in reversing obesity and associated diabetes. Recent observations in humans suggest a contributing role of increased circulating bile acids in mediating such effects. Here we use a diet-induced obesity (DIO) mouse model and compare metabolic remission when bile flow is diverted through a gallbladder anastomosis to jejunum, ileum or duodenum (sham control). We find that only bile diversion to the ileum results in physiologic changes similar to RYGB, including sustained improvements in weight, glucose tolerance and hepatic steatosis despite differential effects on hepatic gene expression. Circulating free fatty acids and triglycerides decrease while bile acids increase, particularly conjugated tauro-β-muricholic acid, an FXR antagonist. Activity of the hepatic FXR/FGF15 signalling axis is reduced and associated with altered gut microbiota. Thus bile diversion, independent of surgical rearrangement of the gastrointestinal tract, imparts significant weight loss accompanied by improved glucose and lipid homeostasis that are hallmarks of RYGB.
Nuclear Induction (1946)

The magnetic moments of nuclei in normal matter will result in a nuclear paramagnetic polarization upon establishment of equilibrium in a constant magnetic field. It is shown that a radiofrequency field at right angles to the constant field causes a forced precession of the total polarization around the constant field with decreasing latitude as the Larmor frequency approaches adiabatically the frequency of the r-f field. Thus there results a component of the nuclear polarization at right angles to both the constant and the r-f field and it is shown that under normal laboratory conditions this component can induce observable voltages. In Section 3 we discuss this nuclear induction, considering the effect of external fields only, while in Section 4 those modifications are described which originate from internal fields and finite relaxation times.
Mass production worthy HfO/sub 2/-Al/sub 2/O/sub 3/ laminate capacitor technology using Hf liquid precursor for sub-100 nm DRAMs (2003)

For the first time, we successfully demonstrated MIS capacitor with ALD (Atomic Layer Deposition) grown HfO/sub 2/-Al/sub 2/O/sub 3/ laminate film using Hf liquid precursor (Hf(NEtMe)/sub 4/) with EOT of 22.5 /spl Aring/ and acceptable leakage currents (1.0 fA/cell at 1.65 V) which is comparable to the smallest reported value. Advantages of Hf(NEtMe)/sub 4/ liquid precursor for DRAM capacitor dielectric are excellent step coverage (94% on high aspect ratio(>40:1)) and reasonable throughput (over two times higher than that of HfCl/sub 4/ solid precursor). This study will provide practical solution for chip-making industry in terms of mass production worthy process for sub-100 nm DRAM capacitor.
Carabametallic Boron Hydride Derivatives. III. The π-C5H5Fe(π-B9C2H11) System (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarabametallic Boron Hydride Derivatives. III. The π-C5H5Fe(π-B9C2H11) SystemM. Frederick Hawthorne and Richard L. PillingCite this: J. Am. Chem. Soc. 1965, 87, 17, 3987–3988Publication Date (Print):September 1, 1965Publication History Published online1 May 2002Published inissue 1 September 1965https://pubs.acs.org/doi/10.1021/ja01095a040https://doi.org/10.1021/ja01095a040research-articleACS PublicationsRequest reuse permissionsArticle Views128Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
AEOL-10150 (Aeolus). (2006)

AEOL-10150, a small-molecule antioxidant analogous to the catalytic site of superoxide dismutase, is under development by Aeolus (formerly Incara) as a potential subcutaneous treatment for amyotrophic lateral sclerosis (ALS), stroke, spinal cord injury, lung inflammation and mucositis. The compound is currently undergoing a phase I clinical trial for ALS. In October 2005, the company had applied for Fast Track status, and planned to submit a special protocol assessment for a pivotal phase II/III trial.
A Nanoporous Metal–Organic Framework Based on Bulky Phosphane Ligands We thank the McClay Trust and the EPSRC for funding, and are grateful to the referees for their suggestions. (2002)

No interpenetration: The use of bulky phosphane ligands allows the preparation of a non-interpenetrating two-dimensional nanoporous structure with hexagonal channels (see picture). In the as-synthesized polymer these channels are saturated with solvent, however, this solvent can be exchanged for other solvents which in turn can be removed by heating under vacuum without collapse of the structure.
Site-directed ligand discovery (2000)

We report a strategy (called "tethering") to discover low molecular weight ligands ( approximately 250 Da) that bind weakly to targeted sites on proteins through an intermediary disulfide tether. A native or engineered cysteine in a protein is allowed to react reversibly with a small library of disulfide-containing molecules ( approximately 1,200 compounds) at concentrations typically used in drug screening (10 to 200 microM). The cysteine-captured ligands, which are readily identified by MS, are among the most stable complexes, even though in the absence of the covalent tether the ligands may bind very weakly. This method was applied to generate a potent inhibitor for thymidylate synthase, an essential enzyme in pyrimidine metabolism with therapeutic applications in cancer and infectious diseases. The affinity of the untethered ligand (K(i) approximately 1 mM) was improved 3,000-fold by synthesis of a small set of analogs with the aid of crystallographic structures of the tethered complex. Such site-directed ligand discovery allows one to nucleate drug design from a spatially targeted lead fragment.
Disability and Mortality in a Cohort of Multiple Sclerosis Patients: A Reappraisal (2005)

The aim of the study was to evaluate how the natural history of multiple sclerosis (MS) had changed over a 15-year period. We compared disability and mortality in a cohort of 83 MS patients hospitalised in the Neurological Institute of Pavia, northern Italy, from January 1, 1990, to December 31, 1991, with a similar cohort of 52 patients analysed in the past. After the follow-up, an unfavourable course (death or relevant disability) was observed in 41% of the patients in the new cohort, compared to 63.5% of the patients in the old one. The percentage of deceased patients was reduced from 25 to 6%. The analysis of the pooled data of the two cohorts indicates a recent tendency of firstly hospitalised patients having a shorter disease duration and a lower disability level, which could explain the relevant decrease both in mortality and disability. Finally, our findings confirmed that age at onset, early disability and a short interval between onset and secondary progression increase the risk of an unfavourable course.
Depth Error Elimination for RGB-D Cameras (2015)

The rapid spreading of RGB-D cameras has led to wide applications of 3D videos in both academia and industry, such as 3D entertainment and 3D visual understanding. Under these circumstances, extensive research efforts have been dedicated to RGB-D camera--oriented topics. In these topics, quality promotion of depth videos with the temporal characteristic is emerging and important. Due to the limited exposure time of RGB-D cameras, object movement can easily lead to motion blurs in intensive images, which can further result in obvious artifacts (holes or fake boundaries) in the corresponding depth frames. With regard to this problem, we propose a depth error elimination method based on time series analysis to remove the artifacts in depth images. In this method, we first locate the regions with erroneous depths in intensive images by using motion blur detection based on a time series analysis model. This is based on the fact that the depth image is calculated by intensive color images that are captured synchronously by RGB-D cameras. Then, the artifacts, such as holes or fake boundaries, are fixed by a depth error elimination method. To evaluate the performance of the proposed method, we conducted experiments on 250 images. Experimental results demonstrate that the proposed method can locate the error regions correctly and eliminate these artifacts effectively. The quality of depth video can be improved significantly by using the proposed method.
Microarray Analysis and Description of Smr1 Gene in Rat Penis in a Post-Radical Prostatectomy Model of Erectile Dysfunction (2003)

Impressive and previously unrecognized genetic changes are being intensely investigated as they are being unmasked by GeneChip technology. We have identified and begun the investigation of 1 interesting family of genes, namely submandibular gland proteins. The role of SMR as a clinically relevant change in penile and/or urethral function following cavernous nerve injury is speculative.
Application of a Ring Closing Metathesis Based Linker to the Solid Phase Synthesis of Oligosaccharides (1999)

A linker allowing a ring closing metathesis mediated cleavage of resin bound oligosaccharides in the form of their 1-O-allyl derivatives was designed. This new linker system for the solid phase synthesis of oligosaccharides via the trichloroacetimidate approach demonstrated highly promising results.