gebhart/patrepeval huggingface dataset:
Polymorphonuclear neutrophils from human immunodeficiency virus- infected patients show enhanced activation, diminished fMLP-induced L- selectin shedding, and an impaired oxidative burst after cytokine priming (1994)

Impaired polymorphonuclear neutrophil (PMN) function may contribute to the onset of certain life-threatening bacterial and fungal infections in human immunodeficiency virus (HIV)-infected patients. Published data on PMN functional activity in HIV infection are controversial, possibly because most studies have involved PMNs isolated from their blood environment by means of various procedures that may differently affect surface receptor expression and thereby alter cellular responses. We therefore used flow cytometry to study the expression of adhesion molecules at the PMN surface, actin polymerization, and the oxidative burst of whole-blood polymorphonuclear neutrophils in 42 HIV-infected patients at different stages of the disease. These PMNs were activated in vivo, as demonstrated by increased expression of the adhesion molecule CD11b/CD18, reduced L-selectin antigen expression, increased actin polymerization, and increased H2O2 production. The alterations were present in asymptomatic patients with CD4+ cell counts greater than 500/microL and did not increase with the progression of the disease. Stimulation by bacterial N-formyl peptides showed dysregulation of L-selectin shedding and decreased H2O2 production after ex vivo priming with tumor necrosis factor alpha or interleukin-8 (IL-8). These latter impairments, which correlated with the decrease in CD4+ lymphocyte numbers and with IL-8 and IL-6 plasma levels, could contribute to the increased susceptibility of HIV-infected patients to bacterial infections.
Diketopiperazines from Marine Organisms (2010)

Diketopiperazines (DKPs), which are cyclic dipeptides, have been detected in a variety of natural resources. Recently, the interest in these compounds increased significantly because of their remarkable bioactivity. This review deals with the chemical structures, biosynthetic pathways, and biological activities of DKPs from marine microorganisms, sponges, sea stars, tunicates (ascidians), and red algae. The literature has been covered up to December 2008, and a total 124 DKPs from 104 publications have been discussed and reviewed. Some of these compounds have been found to possess various bioactivities including cytotoxicity, and antibacterial, antifungal, antifouling, plant-growth regulatory, and other activities.
Modifications chimiques des kératines : Application à la préparation de biomatériaux et étude de leurs propriétés physiques, physico-chimiques et biologiques (1992)

L'un des principaux obstacles rencontres dans la mise au point d'une peau artificielle pour le recouvrement precoce des brules consiste en la preparation d'une structure pseudo-epidermique. La mise au point d'un pseudo-epiderme acellulaire a structure membraneuse et l'etude de ses proprietes physiques, physico-chimiques et biologiques constituent l'essentiel des travaux presentes dans ce memoire. Des S-aminoethylkeratines, derives des keratines solubles en milieu acide, ont ete preparees par reduction des ponts disulfures et transformation chimique au niveau des fonctions thiols de ces proteines. Les films obtenus par evaporation des solutions a temperature controlee sont trans parents, insolubles dans l'eau et les liquides physiologiques, souples sous leur forme hydratee et suffisamment resistants pour etre manipules aisement. L'etude des proprietes physico-chimiques indique que les valeurs de transmission de la vapeur d'eau de ces films sont proches de celles de la peau humaine, qu'ils laissent passer les petites molecules hydrosolubles et les ions mais qu'ils 1 constituent une barriere contre les macromolecules et les agents infectieux. L'etude de leurs proprietes biologiques permet de montrer qu'ils sont biodegradables, faiblement immunogenes et cyto-compatibles vis-a-vis des fibroblastes et des keratinocytes. Les S-aminoethylkeratines peuvent egalement etre associees au collagene ou a d'autres polymeres biologiques pour l'elaboration de biomateriaux, par exemple des obturateurs femoraux a ciment.
Automated video protection, monitoring & detection (2003)

The latest generation of computer vision technology is revolutionizing concepts, applications, and products in video surveillance and CCTV. This is of prime relevance to security for large outdoor facilities such as commercial airfields, refineries, power plants, and office/industrial campuses. Most airfields, for example, have open (unfenced) perimeters, high volume heterogeneous traffic, are easily accessed on foot or by water, and exist in areas where regulations providing a safety buffer are difficult to legislate or enforce. And all airfields require 24/7 outdoor monitoring - snow, fog, rain, or shine. Likewise, most high-value facilities appealing to criminals and terrorists are in close proximity to public areas (roads, residences, city, etc.). The appeal of automated real-time surveillance is obvious $maximizing efficiency and effectiveness of security personnel and resources while increasing the probability of preventing a serious security breach. Computer vision based solutions have the potential for very discriminating detection and very low false alarms. The bottom line is that applied computer vision has the potential for the greatest return on investment (ROI), both short-term and long-term.
Obesity (2006)

The prevalence of obesity is growing at an alarming rate. Thus, investigation into the etiology, comorbidities, and treatment of obesity has burgeoned in recent years. While novel therapies--both behavioral and pharmacological--have been developed and tested, the mean weight losses achieved with nonsurgical approaches have remained virtually unchanged over the past 20 years. Fortunately, the modest weight losses achieved with these methods are associated with significant reductions in obesity-related health problems. With the most intensive available treatment (i.e., bariatric surgery), many patients achieve remission of comorbid conditions. This article defines obesity and provides an overview of the disease conditions associated with excess weight. Treatment options and outcomes are reviewed and future steps-including efforts to prevent obesity--are identified. Finally, the literature on the relationship between obesity and depression is examined.
Prognosis of node-positive colon cancer (1991)

The most recent American Joint Committee on Cancer/International Union Against Cancer (AJCC/UICC) staging system subgroups patients into one to three and four or more positive nodes. However, the Gastrointestinal Study Group and the National Surgical Adjuvant Breast and Bowel Project divides node-positive patients into one to four and five or greater. A Cox multi-variate retrospective analysis was done of the overall survival of node-positive colon cancer patients with the specific objective of determining the most appropriate subcategorization. Data on 306 patients with node-positive colon cancer who underwent potentially curative surgery from 1970 to 1984 were analyzed retrospectively. No patient received adjuvant chemotherapy. Also excluded were patients with synchronous resected metastatic disease or those with rectal primaries. The median follow-up was 6 years, and the median survival for the entire group was 8.6 years. By univariate analysis, the following were significant prognostic features: number of positive nodes (P less than 0.0001), degree of differentiation (P less than 0.0001), colon primary site (P = 0.009), tumor stage (P = 0.001), and tumor size (P less than 0.0001). Lymphatic/blood vessel invasion and a mucinous histology were not significant. By Cox multivariate analysis the number of positive lymph nodes remained the best discriminant of survival (P = 0.0001). The number of positive nodes was related inversely to prognosis with the optimal dichotomization between one to three (66% 5-year survival) and four or greater nodes (37% 5-year survival).
INTRODUCTION: FACILITY LOCATION MODELING (1992)

Papers in Regional ScienceVolume 71, Issue 3 p. 193-197 INTRODUCTION: FACILITY LOCATION MODELING John Current, John Current Academic Faculty of Management Sciences301 Hagerty Hall1775 College RoadColumbus, Ohio 43210-1399USASearch for more papers by this authorSamuel Ratick, Samuel Ratick Center for Technology, Environment, and DevelopmentClark University950 Main StreetWorcester, Massachusetts 01610-1477USASearch for more papers by this author John Current, John Current Academic Faculty of Management Sciences301 Hagerty Hall1775 College RoadColumbus, Ohio 43210-1399USASearch for more papers by this authorSamuel Ratick, Samuel Ratick Center for Technology, Environment, and DevelopmentClark University950 Main StreetWorcester, Massachusetts 01610-1477USASearch for more papers by this author First published: July 1992 https://doi.org/10.1111/j.1435-5597.1992.tb01842.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume71, Issue3July 1992Pages 193-197 RelatedInformation
Regulation of the central glycolytic genes in Bacillus subtilis: binding of the repressor CggR to its single DNA target sequence is modulated by fructose‐1,6‐bisphosphate (2003)

Glycolysis is one of the best and widely conserved general metabolic pathways. Bacillus subtilis enzymes catalysing the central part of glycolysis, gathering the steps of interconversion of the triose phosphates from dihydroxyacetone-phosphate to phosphoenolpyruvate, are encoded by five genes, gapA, pgk, tpi, pgm and eno. They are transcribed in a hexacistronic operon together with cggR, the first cistron, encoding the repressor of this gapA operon. Using deletion analysis, we have localized the CggR operator between the promoter and the first gene of the operon. CggR was purified and used in gel mobility shift assays and DNase I footprinting experiments to delimit its target sequence. Site-directed mutagenesis and in vivo tests demonstrated that it consists of two direct-repeats (CGGGACN6TGTCN4CGGGACN6TG TC). Sequence analysis and transcriptome comparison of a wild-type and a cggR mutant strain strongly suggested that CggR regulates only the gapA operon. The presence of glycolytic carbon sources induces expression of the gapA operon. Genetic experiments allowed us to identify the metabolic steps required for the formation of the CggR effector. In vitro experiments with the suggested candidates allowed us to demonstrate that fructose-1,6-biphosphate (FBP) acts as an inhibitor of CggR DNA-binding activity (10 mM for full inhibition). FBP is thus the major signal for both CcpA-dependent catabolite repression (or activation) and activation of the central glycolytic genes. Genomic sequence comparisons suggest that these results can apply to numerous low-G+C, Gram-positive bacterial species.
CARD10 Is a Novel Caspase Recruitment Domain/Membrane-associated Guanylate Kinase Family Member That Interacts with BCL10 and Activates NF-κB (2001)

BCL10 belongs to the caspase recruitment domain (CARD) family of proteins that regulate apoptosis and NF-kappaB signaling pathways. Analysis of BCL10-deficient mice has revealed that BCL10 mediates NF-kappaB activation by antigen receptors in B and T cells. We recently identified a subclass of CARD proteins (CARD9, CARD11, and CARD14) that may function to connect BCL10 to multiple upstream signaling pathways. We report here that CARD10 is a novel BCL10 interactor that belongs to the membrane-associated guanylate kinase family, a class of proteins that function to organize signaling complexes at plasma membranes. When expressed in cells, CARD10 binds to BCL10 and signals the activation of NF-kappaB through its N-terminal effector CARD domain. We propose that CARD10 functions as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB.
Swelling of articular cartilage and other connective tissues: Electromechanochemical forces (1985)

Abstract We have measured the relationship between tissue swelling stress and consolidation for bovine articular cartilage and corneal stroma in uniaxial confined compression as a function of bath ionic strength. Our experimental protocol and results clearly demonstrate that two concentration‐dependent material properties are necessary to describe the chemical dependence of tissue swelling stress in uniaxial compression over the range of deformations and concentrations explored. A general electromechanochemical model for the swelling stress of charged connective tissues is developed. The model focuses on the role of charged matrix macromolecules in determining the mechanical behavior of the tissue. A constitutive relation for the swelling stress in uniaxial confined compression in formulated and the concentration dependence of the material properties of articular cartilage and corneal stroma is determined. The associated free swelling behavior of cartilage and cornea specimens is computed from these results and is found to compare favorably with data from the literature.
Prediction of magnetically induced electric fields in biological tissue (1991)

There are many potential medical applications in which it is desirable to noninvasively induce electric fields. One such application that serves as the backdrop of this work is that of stimulating neurons in the brain. The magnetic fields necessary must be quite high in magnitude, and fluctuate rapidly in time to induce the internal electric fields necessary for stimulation. Attention is focused on the calculation of the induced electric fields commensurate with rapidly changing magnetic fields in biological tissue. The problem is not a true eddy current problem in that the magnetic fields induced do not influence the source fields. Two techniques are introduced for numerically predicting the fields, each employing a different gauge for the potentials used to represent the electric field. The first method employs a current vector potential (analogous to A in classical magnetic field theory where DEL x A = B) and is best suited to two-dimensional (2-D) models. The second represents the electric field as the sum of a vector plus the gradient of a scalar field; because the vector can be determined quickly using Biot Savart (which for circular coils degenerates to an efficient evaluation employing elliptic integrals), the numerical model is a scalar problem even in the most complicated three dimensional geometry. These two models are solved for the case of a circular current carrying coil near a conducting body with sharp corners.
IMMUNOASSAY OF BOVINE AND HUMAN PARATHYROID HORMONE (1963)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Iron Depletion by Phlebotomy Improves Insulin Resistance in Patients With Nonalcoholic Fatty Liver Disease and Hyperferritinemia: Evidence from a Case-Control Study (2007)

Given that phlebotomy reduces insulin resistance, which is associated with liver tissue damage, future studies should evaluate the effect of iron depletion on liver histology and cardiovascular end points.
Thermal Reshaping of Gold Nanorods in Micelles (1998)

Gold nanorods are prepared in aqueous solution by an electrochemical method and are shape controlled by using capping micelles as described by Yu et al. (J. Phys. Chem. B 1997, 101 (34), 6661). Transmission electron microscopic (TEM) images are determined for these gold nanorods, taken from solutions heated to various temperatures in the range of 25−160 °C. Size and shape analysis of their TEM images showed that the mean aspect ratio of the nanorods in solution decreases with increasing temperature, mostly as a result of reduction in their length. Heating the dried nanorods themselves on a TEM slide to much higher temperatures does not produce any shape changes. This suggests that the observed relative instability of the longer nanorods in the micellar solutions is attributed to the relative instability of the micelles capping the longer gold nanorods. Following the change with time of the longitudinal surface plasmon absorption band of the gold nanorods at five different temperatures, the activation energy for the thermal decomposition of the micelles is found to be 21.0 ± 1.0 K cal mol-1. The most stable rod-shaped micelle is found to have an aspect ratio of 2.0. The craft decomposition (dissolution) temperature of these micelles is found to be ∼155 °C. This study offers a new method in which the thermal stability of micelles of various shapes is used to change the size distribution of metal nanorods in solution. On the other hand, TEM or the absorption maximum of the longitudinal plasmon resonance of gold nanorods can be used as a sensitive monitor in studying the physical properties of the host micelles themselves.
Levels of TGF-α and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival (1998)

Quantitation of EGFR and TGF-alpha protein levels in primary head and neck squamous cell carcinomas may be useful in identifying subgroups of patients at high risk of tumor recurrence and in guiding therapy.
Molecular Characterization of AceB, a Gene Encoding Malate Synthase in Corynebacterium glutamicum (1994)

The aceB gene, encoding for malate synthase, one of the key enzymes of glyoxylate bypass, was isolated from a pMT1-based Corynebacterium glutamicum gene library via complementation of an Escherichia coli aceB mutant on an acetate minimal medium. The aceB gene was closely linked to aceA, separated by 598 base pairs, and transcribed in divergent direction. The aceB expressed a protein product of Mr 83, 000 in Corynebacterium glutamicum which was unusually large compared with those of other malate synthases. A DNA-sequence analysis of the cloned DNA identified an open-reading frame of 2, 217 base pairs which encodes a protein with the molecular weight of 82, 311 comprising 739 aminoo acids. The putative protein product showed only limited amino acid-sequence homology to its counteliparts in other organisms. The N-terminal region of the protein, which shows no apparent homology with the known sequences of other malate synthases, appeared to be responsible for the protein s unusually large size. A potential calciumbinding domain of EF-hand structure found among eukaryotes was detected in the N-terminal region of the deduced protein.
Identification of Sola l 4 as Bet v 1 homologous pathogenesis related-10 allergen in tomato fruits (2014)

Sola l 4, a novel pathogenesis related-10 protein, qualifies as major allergen in tomato fruits. Data suggest Sola l 4 as class II allergen. IgE-testing using Sola l 4 showed low clinical specificity, but high sensitivity in tomato allergic patients and will further improve component-resolved allergy diagnosis.
The KDEL Receptor Modulates the Endoplasmic Reticulum Stress Response through Mitogen-activated Protein Kinase Signaling Cascades (2003)

The accumulation of misfolded proteins in the endoplasmic reticulum (ER) evokes the ER stress response. The resultant outcomes are cytoprotective but also proapoptotic. ER chaperones and misfolded proteins exit to the secretory pathway and are retrieved to the ER, during which process the KDEL receptor plays a significant role. Using an expression of a mutant KDEL receptor that lacks the ability for ligand recognition, we show that the impairment of retrieval by the KDEL receptor led to a mis-sorting of the immunoglobulin-binding protein BiP, an ER chaperone that has a retrieval signal from the early secretory pathway, which induced intense ER stress response and an increase in susceptibility to ER stress in HeLa cells. Furthermore, we show that the ER stress response accompanied the activation of p38 mitogen-activated protein (MAP) kinases and c-Jun amino-terminal kinases (JNKs) and that the expression of the mutant KDEL receptor suppressed the activation of p38 and JNK1 but not JNK2. The effect of the expression of the mutant KDEL receptor was consistent with the effect of a specific inhibitor for p38 MAP kinases, because the inhibitor sensitized HeLa cells to ER stress. We also found that activation of the KDEL receptor by the ligand induced the phosphorylation of p38 MAP kinases. These results indicate that the KDEL receptor participates in the ER stress response not only by its retrieval ability but also by modulating MAP kinase signaling, which may affect the outcomes of the mammalian ER stress response.
Mechanisms of Immune Injury in Rheumatoid Arthritis: Evidence for the Involvement of T Cells and Heat‐Shock Protein (1990)

Evidence for the involvement of T cells, especially CD4+ T cells, in the pathogenesis of RA is substantial and includes 1) the correlation between prolonged CD4+ T-cell depletion and improvement in joint disease in the absence of observable changes in the levels of autoantibodies (rheumatoid factors) in the blood and joints, 2) the infiltration of the inflamed synovial tissues with T cells and, 3) the increased susceptibility of individuals to RA with certain HLA-DR haplotypes. The most direct evidence for the involvement of CD4+ T cells is provided by recent studies which demonstrate rapid improvement in the joint disease manifestations of RA following the infusion of anti-CD4 monoclonal antibodies (Herzog et al. 1989, Walker et al. 1989). It is unlikely that T cells alone are responsible for the joint injury in RA. Autoantibodies (rheumatoid factors) in the joint which contribute to the release of complement breakdown products, and to the secretion of cytokines such as IL-1 by macrophages must also play an important role. Indeed, depletion of CD4+ cells after TLI or therapy with monoclonal antibody reduces, but does not eliminate, joint disease activity. The residual joint disease activity is probably influenced by the continued contribution of autoantibodies to joint injury. Production of these autoantibodies may not be dependent on help from CD4+ cells, since little change is observed in autoantibody levels after CD4+ cell depletion. The mechanisms by which T cells mediate to the joint disease in RA are not clear. Little or no direct evidence of cytotoxic effects of T cells on autologous joint cells has been reported. Considerable evidence suggests that at least some T-cell cytokines (i.e., TNF alpha, IL-6) can contribute to the proliferation of synovial lining cells which results in the marked build-up of inflammatory tissue (pannus) in the joints of patients with RA (Firestein et al. 1990). In addition, T cells may recruit other joint cells, such as macrophages, to secrete cytokines (i.e., IL-1) which both contribute to synovial cell proliferation, and cartilage and bone degeneration. The marked reduction in the spontaneous secretion of IL-1 by synovial biopsies, and improvement in disease activity after TLI support this notion. Interestingly, the CD4+ T-cell lymphokines, IL-2 and IFN-gamma, were not spontaneously secreted in detectable quantities by synovial biopsies. This suggests that the pattern of lymphokines secreted by T cells in the joint in RA are not typical of that in delayed-type hypersensitivity reactions.(ABSTRACT TRUNCATED AT 400 WORDS)