gebhart/patrepeval huggingface dataset:
The design of high power, external antennas for radio frequency multicusp ion sources (2004)

The ion source for the Spallation Neutron Source (SNS) is a radio-frequency, multicusp source designed to deliver H− beam pulses of 45 mA to the SNS accelerator, with a pulse length of 1 ms and a repetition rate of 60 Hz. In order to achieve this performance the source must operate with both high peak rf power, ∼45 kW, and high average rf power, ∼3 kW, over an operational run period of 3 weeks. The most critical source component in this respect is the plasma-immersed, porcelain coated rf antenna which can be susceptible to damage during high power operation. The DESY group has developed an external antenna configuration utilizing an Al2O3 plasma chamber which has demonstrated a very long operational period exceeding 25 000 h. Their source operates with peak rf powers comparable to the SNS source but with greatly reduced average rf powers, ∼50 W. In order to explore the applicability of this external antenna concept to high average power ion sources like the SNS source, we have performed thermal, mechanical, and electromagnetic analyses of the Al2O3 plasma chamber. This article discusses the final design which has resulted from these studies as well as estimates of the power limitations of such devices.
Phase II Study of Carboplatin and Paclitaxel in Advanced Thymoma and Thymic Carcinoma (2011)

Carboplatin plus paclitaxel has moderate clinical activity for patients with thymic malignancies, but this seems less than expected with anthracycline-based therapy. Patients with thymic carcinoma have poorer PFS and overall survival than patients with thymoma.
Other Types of MCM (2001)

The big problem with DMT and OFDM—and any other MCM system that uses rectangular pulsing of sinusoidal carriers (“tones”)—is the sidelobes. In summary, the high-level sidelobes of DMT: 1 Increase the sensitivity to channel distortion. 2 Increase noise enhancement in all linear equalizers and therefore make a guard period essential. 3 Make the problem of digital RFI cancellation (see Section 10.3) much harder. 4 Increase ICI and ISI at the band edges of an FDD system (this is really another manifestation of effect 1: for the wideband DMT signals, the sharp cutoff of the filters is an extreme form of channel distortion). 5 Increase the sensitivity to frequency offset [Armstrong, 1998]; this is not important in DSL systems, but it is very important in broadcast wireless systems, which use unmatched up and down conversion stages. A guard period—and its most common form, the cyclic prefix—does not reduce the sidelobes in any way, but it does ameliorate their effects; it helps with effects 1, 2, and 4, and a shaped cyclic prefix helps a little with RFI cancellation. Most of the (non-DMT) systems discussed in this chapter use one or more of the following methods to reduce the sidelobes: Frequency-domain spreading (i.e., modulating each symbol onto a weighted sum of tones, which then constitute a “subcarrier”); this is often described as maintaining orthogonality on a distorted channel. Filtering of the separate parallel constellation-encoded symbols by means of a weighted sum over several intervals. Time-domain shaping of each symbol.
Signal transduction via the MAP kinases: proceed at your own RSK. (1993)

An explosion of new information linking activation of cell surface signal initiators to changes in gene expression has recently emerged. The focus of much of this information has centered around the agonist-dependent activation of the mitogen-activated protein (MAP) kinases. Although this intracellular signal transduction pathway is extremely complex, conservation of many of its components has been observed in yeast, nematodes, Drosophila, and mammals. Thus, these signaling proteins may participate in the regulation of a variety of cellular processes.
Human prostatic adenocarcinoma: Some characteristics of a serially transplantable line in nude mice (PC 82) (1980)

Transplantation of tissue from a cribriform human prostatic carcinoma resulted in a serially transplantable tumor line in nude mice, PC 82. During 2 1/2 years the tumor has not changed its histological appearance and remained a moderately differentiated adenocarcinoma. The cells contain large amounts of prostatic acid phosphatase. It has a slow rate of growth and regresses after castration and estrogen treatment. This preliminary information suggests that the PC 82 tumor line may be suitable model for hormone-dependent human prostatic cancer.
Intraventricular Immunotoxin Therapy for Leptomeningeal Neoplasia (1997)

Tumoricidal concentrations of the immunotoxin 454A12-rRA can be attained safely in the CSF of patients with leptomeningeal tumor spread.
Synthesis and Photolysis Properties of a Photolabile Linker Based on 3‘-Methoxybenzoin (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSynthesis and Photolysis Properties of a Photolabile Linker Based on 3'-Methoxybenzoin†Ronald S. Rock and Sunney I. ChanView Author Information Arthur Amos Noyes Laboratory of Chemical Physics, 127-72 California Institute of Technology, Pasadena, California 91125 Cite this: J. Org. Chem. 1996, 61, 4, 1526–1529Publication Date (Web):February 23, 1996Publication History Received2 May 1995Revised6 December 1995Published online23 February 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo950822shttps://doi.org/10.1021/jo950822sbrief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views703Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Functional groups,Light,Organic compounds,Peptides and proteins,Photodissociation Get e-Alerts
The interactive performance of SLIM (1999)

Taking the concept of thin clients to the limit, this paper proposes that desktop machines should just be simple, stateless I/O devices (display, keyboard, mouse, etc.) that access a shared pool of computational resources over a dedicated interconnection fabric --- much in the same way as a building's telephone services are accessed by a collection of handset devices. The stateless desktop design provides a useful mobility model in which users can transparently resume their work on any desktop console.This paper examines the fundamental premise in this system design that modern, off-the-shelf interconnection technology can support the quality-of-service required by today's graphical and multimedia applications. We devised a methodology for analyzing the interactive performance of modern systems, and we characterized the I/O properties of common, real-life applications (e.g. Netscape, streaming video, and Quake) executing in thin-client environments. We have conducted a series of experiments on the Sun Ray&trade; 1 implementation of this new system architecture, and our results indicate that it provides an effective means of delivering computational services to a workgroup.We have found that response times over a dedicated network are so low that interactive performance is indistinguishable from a dedicated workstation. A simple pixel encoding protocol requires only modest network resources (as little as a 1Mbps home connection) and is quite competitive with the X protocol. Tens of users running interactive applications can share a processor without any noticeable degradation, and many more can share the network. The simple protocol over a 100Mbps interconnection fabric can support streaming video and Quake at display rates and resolutions which provide a high-fidelity user experience.
Topology-aware navigation in large networks (2009)

Applications supporting navigation in large networks are used every days by millions of people. They include road map navigators, flight route visualization systems, and network visualization systems using node-link diagrams. These applications currently provide generic interaction methods for navigation: pan-and-zoom and sometimes bird's eye views.
A NEW MAPPING METHOD EMPLOYING A MEIOTIC REC- MUTANT OF YEAST (1982)

A rapid new mapping method has been developed for localizing a dominant or recessive mutation to a particular chromosome of yeast. The procedure utilizes the ability of strains homozygous for the spo11-1 mutation to undergo chromosome segregation without appreciable recombination during sporulation. The level of sporulation in spo11-1/spo11-1 diploids is reduced and asci are often immature or abnormal in appearance; spore viability is less than 1%. The first step of the mapping procedure is the construction of a haploid spo11-1 strain carrying a recessive drug-resistance marker and the unmapped mutation(s). This strain is crossed to a set of three spo11-1 mapping tester strains containing, among them, a recessive marker on each chromosome. The resulting spo11-1/spo11-1 diploids are sporulated and plated on drug-containing medium. Viable meiotic products that express the drug-resistance marker due to chromosome haploidization are selectively recovered. These meiotic products are haploid for most, but generally not all, chromosomes. The level of disomy for individual chromosomes averages 19%. Each of the recessive chromosomal markers is expressed in approximately a third of the drug-resistant segregants. Ninety-eight percent of these segregants show no evidence of intergenic recombination. Thus, two markers located on the same chromosome, but on different homologs, are virtually never expressed in the same drug-resistant clone. The utility of this mapping procedure is demonstrated by confirming the chromosomal location of seven known markers, as well as by the assignment of a previously unmapped mutation, spo12-1, to chromosome VIII. In addition, the analysis of the products of spo11-1 meiosis indicates that several markers previously assigned to either chromosome XIV or chromosome XVII are actually on the same chromosome.
Follicular vascularity--the predictive value of transvaginal power Doppler ultrasonography in an in-vitro fertilization programme: a preliminary study (1997)

The aim of this prospective study was to investigate the ability of transvaginal power Doppler ultrasonography to assess the relationship between follicular vascularity and outcome in women undergoing in-vitro fertilization. Each of 38 subjects underwent a single transvaginal power Doppler ultrasound scan on the day of oocyte collection, where the vascularity of individual ovarian follicles was assessed, using a subjective system, and graded 1 to 4. In addition, conventional pulsatility indices (PI) of the uterine and intra-ovarian (stromal) arteries were calculated, which showed no significant differences between the pregnant and non-pregnant groups. Using power Doppler ultrasonography, a total of 188 follicles was studied. The follicular vascularity grade was found to be independent of follicular size and there was no significant difference in fertilization rates with different degrees of vascularity, although there was a trend towards higher fertilization rates with higher grade vascularity. There were 10 pregnancies, giving a pregnancy rate of 26.3% per embryo transfer. Pregnancies were confined to those women whose embryos were derived from follicles with grade 3 and 4 vascularity (pregnancy rates per embryo transfer of 12.5 and 61.5% respectively), with only those from grade 4 follicles resulting in livebirths. This preliminary study suggested that high grade follicular vascularity is associated with increased pregnancy rate and that there is a possible link between follicular vascularity and implantation potential.
Polymer@MOF@MOF: “grafting from” atom transfer radical polymerization for the synthesis of hybrid porous solids (2015)

The application of a core-shell architecture allows the formation of a polymer-coated metal-organic framework (MOF) maintaining high surface area (2289-2857 m(2) g(-1)). The growth of a MOF shell from a MOF core was used to spatially localize initiators by post-synthetic modification. The confinement of initiators ensures that polymerization is restricted to the outer shell of the MOF.
VLSI Architectures for Layered Decoding for Irregular LDPC Codes of WiMax (2007)

We present a new multi-rate architecture for decoding irregular LDPC codes in IEEE 802.16e WiMax standard. The proposed architecture utilizes the value-reuse property of offset min-sum, block-serial scheduling of computations and turbo decoding message passing algorithm. The decoder has the following advantages: 55% savings in memory, reduction of routers by 50%, and increase of throughput by 2times when compared to the recent state-of-the-art decoder architectures.
Inactivation of a GFP retrovirus occurs at multiple levels in long-term repopulating stem cells and their differentiated progeny (2000)

Hematopoietic stem cell gene therapy holds promise for the treatment of many hematologic disorders. One major variable that has limited the overall success of gene therapy to date is the lack of sustained gene expression from viral vectors in transduced stem cell populations. To understand the basis for reduced gene expression at a single-cell level, we have used a murine retroviral vector, MFG, that expresses the green fluorescent protein (GFP) to transduce purified populations of long-term self-renewing hematopoietic stem cells (LT-HSC) isolated using the fluorescence-activated cell sorter. Limiting dilution reconstitution of lethally irradiated recipient mice with 100% transduced, GFP(+) LT-HSC showed that silencing of gene expression occurred rapidly in most integration events at the LT-HSC level, irrespective of the initial levels of GFP expression. When inactivation occurred at the LT-HSC level, there was no GFP expression in any hematopoietic lineage clonally derived from silenced LT-HSC. Inactivation downstream of LT-HSC that stably expressed GFP( )in long-term reconstituted animals was restricted primarily to lymphoid cells. These observations suggest at least 2 distinct mechanisms of silencing retrovirally expressed genes in hematopoietic cells.
Near-infrared electroluminescent devices based on colloidal HgTe quantum dot arrays (2005)

Crystalline 4.6 nm HgTe quantum dots, stabilized by 1-thioglycerol ligands, were synthesized by wet chemical methods. Room-temperature photoluminescence spectra of the dots, both in solution and as solid arrays, exhibited near-infrared emission. Light-emitting devices were fabricated by deposition of quantum dot layers onto glass∕indium tin oxide (ITO)∕3,4-polyethylene-dioxythiophene-polystyrene sulfonate (PEDOT) substrates followed by top contacting with evaporated aluminum. Room-temperature near-infrared electroluminescence from 1mm2 ITO∕PEDOT∕HgTe∕Al devices, centered at ∼1600nm, with an external quantum efficiency of 0.02% and brightness of 150nW∕mm2 at 50 mA and 2.5 V was achieved.
OmpF-Lpp signal sequence mutants with varying charge hydrophobicity ratios provide evidence for a phosphatidylglycerol-signal sequence interaction during protein translocation across the Escherichia coli inner membrane (1993)

Using inverted Escherichia coli inner membrane vesicles we have analyzed the phosphatidylglycerol dependence of translocation of an OmpF-Lpp fusion protein carrying a signal sequence with varying positive charge at the N terminus and a hydrophobic core of varying length. It is shown that there is a direct relationship between the phosphatidylglycerol requirement of translocation and the requirement within the translocation process for positive charges on the signal sequence. This provides further evidence that the negative head group of the lipid is required for functional interaction with the positively charged N terminus of the signal sequence.
Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators (2006)

DNA sequencing by synthesis (SBS) on a solid surface during polymerase reaction offers a paradigm to decipher DNA sequences. We report here the construction of such a DNA sequencing system using molecular engineering approaches. In this approach, four nucleotides (A, C, G, T) are modified as reversible terminators by attaching a cleavable fluorophore to the base and capping the 3'-OH group with a small chemically reversible moiety so that they are still recognized by DNA polymerase as substrates. We found that an allyl moiety can be used successfully as a linker to tether a fluorophore to 3'-O-allyl-modified nucleotides, forming chemically cleavable fluorescent nucleotide reversible terminators, 3'-O-allyl-dNTPs-allyl-fluorophore, for application in SBS. The fluorophore and the 3'-O-allyl group on a DNA extension product, which is generated by incorporating 3'-O-allyl-dNTPs-allyl-fluorophore in a polymerase reaction, are removed simultaneously in 30 s by Pd-catalyzed deallylation in aqueous buffer solution. This one-step dual-deallylation reaction thus allows the reinitiation of the polymerase reaction and increases the SBS efficiency. DNA templates consisting of homopolymer regions were accurately sequenced by using this class of fluorescent nucleotide analogues on a DNA chip and a four-color fluorescent scanner.
Interaction of L‐cysteine with a human excitatory amino acid transporter. (1996)

1. The interaction of L-cysteine with three excitatory amino acid transporter subtypes cloned from human brain (EAAT1-3) was examined by measuring transporter-mediated electrical currents and radiolabelled amino acid flux in voltage-clamped Xenopus oocytes expressing the transporters. 2. L-Cysteine was transported by the neuronal subtype EAAT3 (EAAC1) with an affinity constant of 190 microM and a maximal rate of flux similar to that of L-glutamate; the relative efficacies (Vmax/K(m)) of the EAAT1 and EAAT2 subtypes for transporting L-cysteine were 10- to 20-fold lower. 3. Changing the ionization state of L-cysteine by raising the external pH did not significantly change the apparent affinity, transport rate, or magnitude of currents induced by L-cysteine, suggesting that both the neutral zwitterionic and anionic forms of the amino acid are transported with the same net charge stoichiometry. 4. In addition to competing with L-glutamate for uptake by the neuronal carrier, L-cysteine caused transporter-mediated release of transmitter by heteroexchange; both actions would elevate extracellular glutamate concentrations and may thus contribute to the known excitotoxic actions of L-cysteine in the brain. 5. Because the EAAT3 transporter is also expressed in tissues including kidney and intestine, the results suggest the possibility of a heretofore unrecognized mechanism of L-cysteine uptake in peripheral tissues as well as in brain.
Managed care interventions for improving outcomes in acute heart failure syndromes. (2008)

Acute heart failure syndromes (AHFS) are characterized by a gradual or rapid progression of the signs and symptoms of heart failure (HF), resulting in a need for urgent therapy. Patients with AHFS comprise approximately 20% of all HF patients and represent the most severely ill and undermanaged subpopulation of patients with HF. Despite the rising prevalence and costs associated with AHFS, the disease remains largely undermanaged, partially as a result of a failure to initiate treatment with proven therapies, such as beta-blockers, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers, during hospitalization or soon after discharge. Although professional organizations have been striving to improve the state of care for AHFS by providing at least some level of consensus and evidence-based treatment recommendations, the gap between the clinical evidence and actual practice is growing. Appropriate disease assessment, followed by the implementation of life-saving therapies, is the key to improving outcomes. Managed care initiatives, such as improved quality measures, disease management programs, patient education efforts, hospital discharge checklists, and pharmacy-led interventions to enhance medication compliance, provide potential solutions for combating the alarming rise of morbidity, mortality, and costs associated with this disease.
Differentiation of human T-lymphoid leukemia cells into cells that have a suppressor phenotype is induced by phorbol 12-myristate 13-acetate. (1982)

Treatment of cultured human T-lymphoid (CEM) leukemia cells with nanomolar concentrations of phorbol 12-myristate 13-acetate (PMA) resulted in a reduction in cell growth and in the acquisition of a surface antigenic pattern that is common to both suppressor and cytotoxic T lymphocytes. This antigenic pattern was detected by OKT monoclonal antibodies. PMA treatment did not cause the expression of a cytotoxic function but rather induced the expression of a suppressor cell marker. This marker was characterized by the ability of the treated CEM cells to suppress [3H]thymidine incorporation into phytohemagglutinin-activated peripheral blood lymphocytes. After 4 days of treatment of CEM cells from either cloned or the parental cell population with 16 nM PMA, 71-98% of the cells expressed reactivity with OKT3 and OKT8 antibodies whereas reactivity with OKT4 and OKT6 was detected in less than or equal to 1-8% of the cells. The CEM cells can be divided into five groups based on the antigenic patterns of cells from randomly isolated clones. The cells from four of these groups were characterized by either low or high reactivity with each of the four OKT antibodies. The antigenic pattern of the fifth group resembled that of the parent CEM cells. The acquisition of reactivity with the OKT3 antibody in the CEM cells after PMA treatment was dependent on both time and dose and did not require cell replication. Acquisition of reactivity with OKT3 antibody also occurred after treatment with phorbol 12,13-dibutyrate but not after treatment with phorbol 13-monoacetate, phorbol 12,13-diacetate, or dimethyl sulfoxide. These results indicate that treatment of CEM cells with PMA and related agents can cause the cells to express a phenotype that resembles that of a mature suppressor T lymphocyte.