gebhart/patrepeval huggingface dataset:
Gastric mucosal hydrophobicity and Helicobacter pylori: response to antimicrobial therapy. (1993)

The hydrophobic properties of the gastric mucosa are reduced by NSAIDs and by Helicobacter pylori infection. Our investigation was to determine whether this abnormality was due to the bacteria or to the inflammatory response. Contact angle measurements were made on gastric antral and corpus biopsies taken from 10 H. pylori-infected volunteers before eradication therapy, after 2 and 14 days of therapy, and 4 weeks after therapy. The contact angle improved steadily and statistically throughout the 2 weeks of therapy (for day 0, 3, 14, respectively) antral mucosa 54.2 +/- 2, 59.3 +/- 2, and 63.2 +/- 2; corpus mucosa 55 +/- 1, 57.8 +/- 3, and 66.6 +/- 1. After 2 days of therapy, H. pylori bacteria were no longer evident, and yet the contact angle continued to improve, suggesting that bacteria and bacterial products (e.g., lipases) may not be critical factors. H. pylori was eradicated in five and failed in five. One month after ending therapy, the contact angles of those with recrudescence of infection and those with eradication were similar and higher (p < 0.05) than before therapy (antrum: 69.8 +/- 1 vs. 71.1 +/- 2, corpus: 66.4 +/- 4 vs. 70.8 +/- 2) (p > 0.25 for both). We conclude that gastric surface hydrophobicity abnormalities do not appear to be directly related to the presence of H. pylori organisms or the histologic features of acute inflammation, but are responsive to antimicrobial therapy.
Efficient handling ofN-gram language models for statistical machine translation (2007)

Statistical machine translation, as well as other areas of human language processing, have recently pushed toward the use of large scale n-gram language models. This paper presents efficient algorithmic and architectural solutions which have been tested within the Moses decoder, an open source toolkit for statistical machine translation. Experiments are reported with a high performing baseline, trained on the Chinese-English NIST 2006 Evaluation task and running on a standard Linux 64-bit PC architecture. Comparative tests show that our representation halves the memory required by SRI LM Toolkit, at the cost of 44% slower translation speed. However, as it can take advantage of memory mapping on disk, the proposed implementation seems to scale-up much better to very large language models: decoding with a 289-million 5-gram language model runs in 2.1Gb of RAM.
Good results with an uncemented proximally HA-coated stem in hip revision surgery: 62 hips followed for 2–13 years (2008)

Uncemented revision with a short, proximally hydroxyapatite-coated prosthesis is a reliable procedure with encouraging results in the medium term if bone defects at revision are moderate.
Implementation of molecular replacement in AMoRe (2001)

An account is given of the molecular replacement method as implemented in the package AMoRe. The overall strategy of the method is presented and the main functions used in the package are described. The most important features of AMoRe are the quality of the fast rotation and translation functions and the facility of multiple inputs to translation and rigid-body refinement functions, which allow for a fast multiple exploration of crystal configurations with a high level of automation.
Treatment-Resistant Postictal Agitation After Electroconvulsive Therapy (ECT) Controlled With Dexmedetomidine (2013)

Emergence agitation is a common complication of electroconvulsive therapy. Standard supportive and pharmacological interventions are usually effective management strategies. We report a case of severe agitation after electroconvulsive therapy that was refractory to the usual treatments but was controlled with dexmedetomidine.
Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinsonʼs disease (1994)

Direct intracerebral gene transfer to neural cells has been demonstrated with recombinant adenovirus encoding beta-galactosidase. To explore the potential of recombinant adenovirus for the therapy of neurological disease we constructed a recombinant adenovirus encoding tyrosine hydroxylase and optimized intracerebral injection to express the gene in the striatum of unilaterally denervated rats. These animals have dopamine depletion in their lesioned striatum, causing a rotation asymmetry induced by apomorphine. One and two weeks after intracerebral injection this sensorimotor asymmetry was decreased by the adenovirus encoding tyrosine hydroxylase and not by a control adenovirus encoding beta-galactosidase. Histological analysis showed that tyrosine hydroxylase was preferentially expressed in astrocytes.
Citrullination of synovial proteins in murine models of rheumatoid arthritis (2003)

Citrullination of synovial antigens is an active process during joint inflammation in both mice and humans, but the induction of autoantibodies directed to these proteins is a more specific phenomenon, detectable only in human RA patients.
A generalized array manifold model for local scattering in wireless communications (2002)

In wireless communication scenarios, local scatterers in the vicinity of the mobile sources cause angular spreading. As a result, the spatial signatures will not belong to the conventional array manifold parameterized by direction of arrival (DOA) alone. A parameterized model for spatial signatures applicable in scenarios with local scattering is presented. Several algorithms that exploit this model are proposed, and the performance of signal waveform estimators using the model is investigated via simulations. It is demonstrated that considerable gain may result as compared with using the conventional plane wave model.
Risperidone in Children with Autism and Serious Behavioral Problems (2002)

Risperidone was effective and well tolerated for the treatment of tantrums, aggression, or self-injurious behavior in children with autistic disorder. The short period of this trial limits inferences about adverse effects such as tardive dyskinesia.
Molecular Limit of a Bulk Semiconductor:  Size Dependence of the “Band Gap” in CdSe Cluster Molecules (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTMolecular Limit of a Bulk Semiconductor: Size Dependence of the "Band Gap" in CdSe Cluster MoleculesV. N. Soloviev, A. Eichhöfer, D. Fenske, and U. BaninView Author Information Department of Physical Chemistry and the Farkas Center for Light Induced Processes The Hebrew University, Givat Ram Jerusalem 91904, Israel Institut für Nanotechnologie, Forschungszentrum Karlsruhe, Postfach 3640, 76021 Karlsruhe, Germany Institut für Anorganische Chemie der Universität Karlsruhe, Engesserstrasse Geb. 30.45 D-76128 Karlsruhe, Germany Cite this: J. Am. Chem. Soc. 2000, 122, 11, 2673–2674Publication Date (Web):March 22, 2000Publication History Received17 November 1999Published online22 March 2000Published inissue 1 March 2000https://pubs.acs.org/doi/10.1021/ja9940367https://doi.org/10.1021/ja9940367rapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views5829Altmetric-Citations258LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Absorption,Cadmium selenide,Cluster chemistry,Electrical conductivity,Molecules Get e-Alerts
Catalytic Conversion of Used Oil to Hydrocarbon Fuels in a Fractionating Pyrolysis Reactor (1998)

Pyrolysis of used sunflower oil was carried out in the presence of different amounts of HZSM-5 at 400 and 420 °C in a reactor equipped with a fractionating packed column, the length of which was varied. The products consisted of gaseous and liquid hydrocarbons, acids, CO, CO2, water, and coke. The compositions of the gaseous and liquid products were studied by gas chromatography. The product yields and compositions were affected by catalyst content, temperature, and column length. Nearly complete conversion (96.6%) of the used oil and the maximum liquid hydrocarbon yield (33%) were obtained at the highest temperature (420 °C), highest catalyst content (20%), and the lowest column length (180 mm) employed. The aromatic hydrocarbon contents of the liquid hydrocarbon products, which consisted of hydrocarbons of gasoline range, were in general lower than those obtained using fixed bed reactors but increased parallel to the increase in catalyst content. Additional thermal reactions taking place in this type of reactor increased with the increase in column length. Although the total conversion and total liquid hydrocarbon yields were influenced adversely by these reactions, liquid products with higher isomeric hydrocarbon contents were obtained with longer columns.
Using information technology to reduce rates of medication errors in hospitals (2000)

Data continue to show that medication errors are frequent and that adverse drug events, or injuries due to drugs, occur more often than necessary.1–4 In fact, the frequency and consequences of iatrogenic injuries seems to dwarf the frequency of other types of injuries that have received more public attention, such as aeroplane and automobile crashes.2 A recent meta-analysis reported an overall incidence of 6.7% for serious adverse drug reactions (a term that excludes events associated with errors) in hospitals.4 Between 28% and 56% of adverse drug events are preventable. 3 5–7

Though the reasons this issue has received so little attention are complex, the reasons that medical injuries occur with some frequency are perhaps less so; medicine is more or less a cottage industry, with little standardisation and relatively few safeguards in comparison to, say, manufacturing. In fact, most of the systems in place in medicine were never formally designed, and this holds for the entire process of giving drugs.

#### Summary points

Although information technologies are widely used in hospitals, relatively few data are available regarding their impact on the safety of the process of giving drugs

Exceptions are computerised physician order entry and computerised physician decision support, which have been found to improve drug safety

Other innovations, including using robots to fill prescriptions, bar coding, automateddispensing devices, and computerisation of the medication administration record, though less studied, should all eventually reduce error rates

The medication system of the future will include these and other technologies, all electronically linked

Take, for example, the allergy detection process used in our hospital several years ago, which was similar to that used in most hospitals at the time. Physicians, medical students, and nurses all asked patients what their allergies were. This information was recorded at several sites in …
A Study of the Ion Beam Intensity and Divergence Obtained from a Single Aperture Three Electrode Extraction System (1973)

Experimental results are given for the perveance and beam divergence of a single aperture three electrode extraction system using helium ions at energies between 10 and 30 keV. The aperture radii, the electrode thicknesses, and the spacings were varied and from the results a preferred design was obtained for use in a multiaperture array. The most critical parameter was the ratio (S) of the radius of the first aperture to the distance between the first and second electrodes, the highest current density being obtained at values of this ratio less than 0.5. The optimum beam divergence observed corresponded to a Gaussian beam profile with a width (ω) of ± 1.2° at 2 m from the source. The measured perveance at small values of S and at minimum ω lay between 75% and 90% of the value predicted on the basis of a simple model using the Langmuir-Blodgett formula for the spherical diode.
[The clinical efficacy of treating patients with nonspecific lung diseases using low-energy laser irradiation and intrapulmonary drug administration]. (1991)

Intrapulmonary administration of glucocorticosteroids and antibiotics combined with low-energy laser radiation was employed in the treatment of patients with infection-dependent bronchial asthma in the phase of exacerbation and frequent asphyxia attacks, long medical history and of patients with lung abscesses. The purpose of the work was to study and compare the clinical effectiveness of the method in the gravest group of patients suffering from nonspecific pulmonary diseases: suppurative (acute lung abscess) and infectious allergic (infection-dependent bronchial asthma of medium gravity with frequent attacks, long medical history, tendency towards aggravation of the status and low efficacy of broncholytics). The results of the treatment and follow-up have shown that the use of the combined treatment suggested is most optimal in patients with acute lung abscesses (the percentage of the cured is 94.1). In patients with infection-dependent bronchial asthma, the use of laser therapy combined with intrapulmonary administration of steroids also noticeably improved the clinical, functional and immunological characteristics, prolonged the phase of remission.
Pulmonary afferent activity recorded from sympathetic nerves (1975)

This study in mongrel dogs, anesthetized with sodium pentobarbital, verified the existence of pulmonary receptors whose afferents traverse the right and left upper thoracic white rami communicantes. These receptors responded to lung inflation as well as pinching of the lung parenchyma and were nonadapting in nature. In some fibers, increases in afferent activity were also observed when the pulmonary artery and veins were mechanically stimulated by probing. Conduction velocities of these afferents were measured in single-fiber preparations and were of the Adelta fiber type.
High Methane Storage Capacity in Aluminum Metal–Organic Frameworks (2014)

The use of porous materials to store natural gas in vehicles requires large amounts of methane per unit of volume. Here we report the synthesis, crystal structure and methane adsorption properties of two new aluminum metal-organic frameworks, MOF-519 and MOF-520. Both materials exhibit permanent porosity and high methane volumetric storage capacity: MOF-519 has a volumetric capacity of 200 and 279 cm(3) cm(-3) at 298 K and 35 and 80 bar, respectively, and MOF-520 has a volumetric capacity of 162 and 231 cm(3) cm(-3) under the same conditions. Furthermore, MOF-519 exhibits an exceptional working capacity, being able to deliver a large amount of methane at pressures between 5 and 35 bar, 151 cm(3) cm(-3), and between 5 and 80 bar, 230 cm(3) cm(-3).
Self-referenced Doppler optical coherence tomography (2002)

Doppler optical coherence tomography (DOCT) allows simultaneous micrometer-scale resolution cross-sectional imaging of tissue structure and blood flow. We demonstrate a fiber-optic polarization-diversity-based differential phase contrast DOCT system as a method to perform self-referenced velocimetry in highly scattering media. Using this strategy, we reduced common-mode interferometer noise to <1 Hz and improved Doppler estimates in a scattering flow phantom by a factor of 5.
Anti‐IL‐6 receptor mAb eliminates myeloid‐derived suppressor cells and inhibits tumor growth by enhancing T‐cell responses (2012)

CD11b(+) Gr-1(+) immature myeloid cells (ImCs), which are abnormally increased in tumor-bearing mice, were classified into three different subsets according to their phenotypic and morphological characteristics: Gr-1(low) F4/80(+) macrophages (MΦ-ImCs), Gr-1(mid) stab neutrophils (Neut(stab)-ImCs), and Gr-1(high) segmented neutrophils (Neut(seg)-ImCs). In the spleen, only MΦ-ImCs but not Neut(stab)-ImCs and Neut(seg)-ImCs exhibited a significant immunosuppressive activity in MLR. In contrast, tumor-infiltrating leukocytes (TILs) contained only two ImC subsets, MΦ-ImCs and Neut(seg)-ImC, both of which exhibited stronger inhibitory activity against T cells compared with spleen-MΦ-ImCs. Thus, we concluded that tumor-infiltrating MΦ-ImCs and Neut(seg)-ImCs were fully differentiated myeloid-derived suppressor cells (MDSCs) with stronger T-cell inhibitory activity. Indeed, spleen MΦ-ImCs were converted into stronger MΦ-MDSCs by tumor-derived factor (TDF). Moreover, both spleen Neut(stab)-ImCs and Neut(seg)-ImCs differentiated into Neut(seg)-MDSCs with suppressive activity after culture with TDF. We first demonstrated that administration of anti-IL-6R mAb could downregulate the accumulation of MΦ-MDSCs and Neut(seg)-MDSCs in tumor-bearing mice. The elimination of those MDSCs caused subsequent enhancement of antitumor T-cell responses, including IFN-γ-production. The therapeutic effect of anti-IL-6R mAb was further enhanced by combination with gemcitabine (GEM). Thus, we propose that anti-IL-6R mAb could become a novel tool for the downmodulation of MDSCs to enhance antitumor T-cell responses in tumor-bearing hosts.
Genome wide transcriptional profiling in breast cancer cells reveals distinct changes in hormone receptor target genes and chromatin modifying enzymes after proteasome inhibition (2008)

Steroid hormone receptors, like glucocorticoid (GR) and estrogen receptors (ER), are master regulators of genes that control many biological processes implicated in health and disease. Gene expression is dependent on receptor levels which are tightly regulated by the ubiquitin-proteasome system. Previous studies have shown that proteasome inhibition increases GR, but decreases ER-mediated gene expression. At the gene expression level this divergent role of the proteasome in receptor-dependent transcriptional regulation is not well understood. We have used a genomic approach to examine the impact of proteasome activity on GR- and ER-mediated gene expression in MCF-7 breast cancer cells treated with dexamethasone (DEX) or 17beta-estradiol (E2), the proteasome inhibitor MG132 (MG) or MG132 and either hormone (MD or ME2) for 24 h. Transcript profiling reveals that inhibiting proteasome activity modulates gene expression by GR and ER in a similar manner in that several GR and ER target genes are upregulated and downregulated after proteasome inhibition. In addition, proteasome inhibition modulates receptor-dependent genes involved in the etiology of a number of human pathological states, including multiple myeloma, leukemia, breast/prostate cancer, HIV/AIDS, and neurodegenerative disorders. Importantly, our analysis reveals that a number of transcripts encoding histone and DNA modifying enzymes, prominently histone/DNA methyltransferases and demethylases, are altered after proteasome inhibition. As proteasome inhibitors are currently in clinical trials as therapy for multiple myeloma, HIV/AIDS and leukemia, the possibility that some of the target molecules are hormone regulated and chromatin modifying enzymes is intriguing in this era of epigenetic therapy.
Development of laser-arc hybrid welding (2002)

Laser-arc hybrid welding combines the laser and arc welding processes to provide advantages not found in either. This process can weld lapped steel sheets that have a larger gap than is possible with laser welding. Blowholes form when lap-welding zinc-coated steel sheets because of the zinc that is vaporized. The laser-arc hybrid welding process can lap-weld zinc-coated steel sheets without causing blowholes. The welding speed of laser-arc hybrid welding is nearly equivalent to that of laser welding. Laser-arc hybrid welding produces high-quality lap joints and is ideal for assembly welding of automotive parts.
Sequential One‐Pot Reactions Using the Concept of “Site Isolation” (2006)

Acidic and basic sites can be isolated by incorporation in the core of star-shaped polymers (see picture). Fréchet, Hawker, and co-workers have used these polymer-based catalysts for homogeneous-phase one-pot multistep reactions. Similarly, Kaneda et al. have demonstrated the site-isolation concept in heterogeneous systems by use of different types of layered clays.
Plasmin-induced Migration of Endothelial Cells (2002)

Angiostatin, a plasminogen fragment containing 3-4 N-terminal kringle domains, is a potent inhibitor of tumor-induced angiogenesis, but its mechanism of action is unclear. Angiostatin is a ligand for integrin alphavbeta(3) but does not induce stress fiber formation upon integrin binding, suggesting that angiostatin is a potential integrin antagonist. Plasmin, the parent molecule of angiostatin and a major extracellular protease, induces platelet aggregation, migration of peripheral blood monocytes, and release of arachidonate and leukotriene from several cell types. In the current study, we found that plasmin specifically bound to alphavbeta(3) through the kringle domains and induced migration of endothelial cells. In contrast, angiostatin did not induce cell migration. Notably, angiostatin, anti-alphavbeta(3) antibodies, RGD-peptide, and a serine protease inhibitor effectively blocked plasmin-induced cell migration. These results suggest that plasmin-induced migration of endothelial cells requires alphavbeta(3) and the catalytic activity of plasmin and that this process is a potential target for the inhibitory activity of angiostatin.
394. Chloroboration and allied reactions of unsaturated compounds. Part III. Aminoboration and alkoxyboration of isocyanates and isothiocyanates (1964)

R. H. Cragg, M. F. Lappert and B. P. Tilley, J. Chem. Soc., 1964, 2108 DOI: 10.1039/JR9640002108