gebhart/patrepeval huggingface dataset:
Claus Arnold, Giacomo Losito, « Lamentabili sane exitu » (1907). Les documents préparatoires du Saint-Office. Rome, Libreria Editrice Vaticana, 2011, 546 p. (2013)

Le 8 juillet 1907, le Saint-Office condamne, par le decret Lamentabili sane exitu, 65 propositions tirees des œuvres d’Alfred Loisy (rappelons que cette meme annee, en septembre, ce dernier sera frappe par une autre condamnation : celle de l’encyclique Pascendi, du pape Pie X, « sur les erreurs du modernisme »). Grâce a l’ouverture des Archives de la Congregation pour la Doctrine de la Foi en 1998 (archives en cours d’edition et de publication), C. Arnold et G. Losito ont eu acces aux documen...
Design and implementation of AC-3 coders (1995)

AC-3 is the perceptual coding technology used for HDTV audio compression. This paper describes the design and implementation of AC-3 coders, focusing on issues relevant to minimum cost solutions. AC-3 coding technology has been adopted by the Advanced Television Systems Committee (ATSC) as the audio service standard for high definition television (HDTV) in the United States. The AC-3 audio data compression system is described, and an overview of encoding and decoding strategies is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Atrial Natriuretic Peptide Elevation in Congestive Heart Failure in the Human (1986)

A sensitive radioimmunoassay for atrial natriuretic peptide was used to examine the relation between circulating atrial natriuretic peptide and cardiac filling pressure in normal human subjects, in patients with cardiovascular disease and normal cardiac filling pressure, and in patients with cardiovascular disease and elevated cardiac filling pressure with and without congestive heart failure. The present studies establish a normal range for atrial natriuretic peptide in normal human subjects. These studies also establish that elevated cardiac filling pressure is associated with increased circulating concentrations of atrial natriuretic peptide and that congestive heart failure is not characterized by a deficiency in atrial natriuretic peptide, but with its elevation.
Flow cytometric enumeration of CD34+ hematopoietic stem and progenitor cells (1998)

The need for a rapid and reliable marker for the engraftment potential of hematopoietic stem and progenitor cell (HPC) transplants has led to the development of flow cytometric assays to quantitate such cells on the basis of their expression of CD34. The variability associated with enumeration of low-frequency cells (i.e., as low as 0.1% or 5 cells/microl) is exceedingly large, but recent developments have improved the accuracy and precision of the assay. Here, we review and compare the major techniques. Based on the current state of the art, we recommend 1) bright fluorochrome conjugates of class II or III monoclonal antibodies (mAbs) that detect all glycoforms of CD34, 2) use of a vital nucleic acid dye to exclude platelets, unlysed red cells, and debris or use of 7-amino actinomycin D to exclude dead cells during data acquisition, 3) counterstaining with CD45 mAb to be included in the definition of HPC, 4) during list mode data analysis, Boolean gating to resolve the CD34+ HPCs from irrelevant cell populations on the basis of the low levels of CD45 expression and low sideward light-scatter signals of HPCs, 5) inclusion of CD34dim and CD34bright populations in the CD34+ cell count, 6) omission of the negative control staining, and 7) for apheresis products, enumeration of at least 100 CD34+ cells to ensure a 10% precision. Unresolved technical questions are 1) the replacement of conventional dual-platform by single-platform assay formats, i.e., derivation of absolute CD34+ cell counts from a single flow cytometric assessment instead of from combined flow cytometer (percent CD34+) and hematology analyzer (absolute leukocyte count) data, 2) the cross-calibration of the available single-platform assays, and 3) the optimal method for sample preparation. An important clinical question to be addressed is the definition of the precise phenotypes and required numbers of HPCs responsible for short- and long-term recovery to optimize HPC transplant strategies.
Soft-error detection using control flow assertions (2003)

Over the last few years, an increasing number of safety-critical tasks have been demanded of computer systems. In this paper, a software-based approach for developing safety-critical applications is analyzed. The technique is based on the introduction of additional executable assertions to check the correct execution of the program control flow. By applying the proposed technique, several benchmark applications have been hardened against transient errors. Fault injection campaigns have been performed to evaluate the fault detection capability of the proposed technique in comparison with state-of-the-art alternative assertion-based methods. Experimental results show that the proposed approach is far more effective than the other considered techniques in terms of fault detection capability, at the cost of a limited increase in memory requirements and in performance overhead.
Dendritic Cells: Origin and Differentiation (1996)

Dendritic cells (DC) are bone marrow-derived cells that are specialized to take up, process and present antigen, and have the capacity to stimulate resting T cells in the primary immune response. DC are a unique population that is likely to derive from a myeloid precursor cell. DC differentiation from bone marrow precursors in enhanced by the cytokines GM-CSF and tumor necrosis factor-alpha. In contrast, it has been proposed that thymic DC and T cells arise from a common stem cell, and that these DC play a specific role in the negative selection of thymic T cells. A number of post-bone marrow differentiation stages can be defined phenotypically and functionally. Undifferentiated DC have very active endocytic pathways, including receptor-mediated endocytosis involving a mannose/beta glucan receptor, and macropinocytosis of soluble antigen. In contrast, later stages of maturation are associated with a decreased ability to take up and process antigen, and increasing expression of major histocompatibility complex, adhesion and costimulatory molecules. Finally, activation of DC for full antigen-presenting cell function can be identified by the expression of CD28 ligands. The inflammatory site in rheumatoid arthritis is a human model of DC differentiation in response to a chronic antigenic stimulus. The features of this DC model are discussed.
Safe and Convenient Procedure for Solvent Purification (1996)

This contribution describes a general method for the purification of solvents for use with air and moisture sensitive reactions. This procedure provides a nonhazardous alternative to distillations and vacuum transfers and does not require undue supervision or cooling, yet allows for the rapid collection of large quantities of extremely pure solvents on demand. Solvents are rigorously degassed in 18 L reservoirs and passed through two sequential purification columns. Protic contaminants are removed with activated alumina, while a supported copper catalyst is used to remove trace oxygen from hydrocarbons. The purification system is interfaced with either a glove box or Schlenk manifold for the anhydrous/anaerobic collection of solvents. Solvents purified by this method and tested with stock solutions of sodium benzophenone ketyl or titanocene dichloride/zinc dust are free of oxygen at least to the ppm level. Furthermore, this system may be used for the in-line purification of gases and is easily scaled down to provide a convenient method for the purification of deuterated solvents or other reagents.
Layer-3 switching using virtual network ports (2003)

Switching techniques are capable of providing scalable forwarding performance, traffic engineering and quality of service, which are necessary for the next-generation Internet. Switching techniques achieve this by forwarding packets below the network layer, setting up aggregated flows, and laying explicit routes. The proposed framework improves on the current switching techniques. A virtual network port provides a conduit below layer-3 to network ports on remote nodes. It eliminates the need for explicit stack operations and packet fragmentation. It has active controls that allow processing of packets flowing through. We feel that it is conceptually simpler and has better semantics than the other techniques. In this paper we describe an implementation of the framework.
Effect of Tetrahydropyrimidine Derivatives on Protein-Nucleic Acids Interaction (1999)

2-Methyl-4-carboxy,5-hydroxy-3,4,5,6-tetrahydropyri- midine (THP(A) or hydroxyectoine) and 2-methyl,4-carboxy-3,4,5, 6-tetrahydropyrimidine (THP(B) or ectoine) are now recognized as ubiquitous bacterial osmoprotectants. To evaluate the impact of tetrahydropyrimidine derivatives (THPs) on protein-DNA interaction and on restriction-modification systems, we have examined their effect on the cleavage of plasmid DNA by 10 type II restriction endonucleases. THP(A) completely arrested the cleavage of plasmid and bacteriophage lambda DNA by EcoRI endonuclease at 0.4 mM and the oligonucleotide (d(CGCGAATTCGCG))2 at about 4.0 mM. THP(B) was 10-fold less effective than THP(A), whereas for betaine and proline, a notable inhibition was observed only at 100 mM. Similar effects of THP(A) were observed for all tested restriction endonucleases, except for SmaI and PvuII, which were inhibited only partially at 50 mM THP(A). No effect of THP(A) on the activity of DNase I, RNase A, and Taq DNA polymerase was noticed. Gel-shift assays showed that THP(A) inhibited the EcoRI-(d(CGCGAATTCGCG))2 complex formation, whereas facilitated diffusion of EcoRI along the DNA was not affected. Methylation of the carboxy group significantly decreased the activity of THPs, suggesting that their zwitterionic character is essential for the inhibition effect. Possible mechanisms of inhibition, the role of THPs in the modulation of the protein-DNA interaction, and the in vivo relevance of the observed phenomena are discussed.
Improved HBT linearity with a "post-distortion"-type collector linearizer (2003)

An HBT amplifier with a "post-distortion"-type linearizer utilizing a base-collector junction diode shows more than 8-dB improvement of adjacent channel power ratio, and the collector linearizer comprising a reverse biased base-collector junction diode requires no additional dc power consumption and has no deterioration of RF performance. The linearization technique of post-distortion compensates the nonlinearity of HBTs, which arises from the C/sub bc/ variation due to a large-signal swing.
Expression of Interleukin-1alpha, Interleukin-6, and Basic Fibroblast Growth Factor by Cultured Skin Substitutes before and after Grafting to Full-Thickness Wounds in Athymic Mice (1996)

The sequence of cytokine synthesis in the wounds (i.e., rapid IL-1alpha increase followed by IL-6 expression) parallels serum levels reported after a septic challenge. These findings support the hypothesis that the wound is a source of systemic cytokines.
Preparation of Highly Functionalized Imidazoles from α-Azidoacetonitrile: X-ray Crystal Structure of 4-Methoxy-2-methylamino-5-methylthiocarbamoylimidazole (1995)

The Pinner salt 2 derived from α-azidoacetonitrile by sequential treatment with triethylamine, triphenylphosphine and acyl chlorides or isothiocyanates was converted into the corresponding imidazole 5 or 6, respectively. The crystal structure of 6a has been determined by X-ray diffraction methods. Dimers of centrosymmetrically related molecules, linked by N-H...N bonds, join together to infinite chains through N-H...S=C halogen interactions.
Characterization of six new capsular types (23 through 28) of Streptococcus suis (1991)

Six new capsular types of Streptococcus suis (types 23 to 28) are described. All reference strains were isolated from diseased pigs and were morphologically and biochemically similar to previously described capsular types 1 to 22. Clear and specific reactions were obtained for each of the new capsular types with three different typing techniques; no cross-reactions were detected among them or with other S. suis capsular types. Their capsular material presented similar ultrastructural characteristics, as shown by electron microscopy, and fimbriae similar to those described for other capsular types of S. suis were observed. When untypeable field isolates were tested with antisera raised against the six new capsular types, capsular type 23 appeared to be the most prevalent, representing more than 50% of all these isolates. Most isolates were recovered from cases of pneumonia, septicemia, and meningitis. Presumptive biochemical identification described for S. suis capsular types 1 to 22 may also be used for capsular types 23 to 28.
Assessment of high-heat-flux thermal management schemes (2001)

This paper explores the recent research developments in high-heat-flux thermal management. Cooling schemes such as pool boiling, detachable heat sinks, channel flow boiling, microchannel and mini-channel heat sinks, jet-impingement, and sprays, are discussed and compared relative to heat dissipation potential, reliability, and packaging concerns. It is demonstrated that, while different cooling options can be tailored to the specific needs of individual applications, system considerations always play a paramount role in determining the most suitable cooling scheme. It is also shown that extensive fundamental electronic cooling knowledge has been amassed over the past two decades. Yet there is now a growing need for hardware innovations rather than perturbations to those fundamental studies. An example of these innovations is the cooling of military avionics, where research findings from the electronic cooling literature have made possible the development of a new generation of cooling hardware which promise order of magnitude increases in heat dissipation compared to today's cutting edge avionics cooling schemes.
Antifungal properties in a novel series of triazino[5,6-b]indoles (1993)

GR99060 and GR99062 are representatives of a series of 1,2,4-triazino[5,6-b]indole compounds. This series possessed broad-spectrum antifungal activity in vitro. The MIC ranges of the two compounds were as follows: 0.25 to 4 micrograms/ml for Candida albicans, 0.25 to 16 micrograms/ml for Candida sp., 1 to 8 micrograms/ml for Aspergillus spp., and 0.25 to 16 micrograms/ml for Cryptococcus neoformans. GR99062 was metabolized in vitro by a mouse liver microsomal preparation, while GR99060 was stable. GR99060 was efficacious in a murine model of systemic candidiasis by oral or parenteral administration, although no clear dose-response was achieved, suggesting that other factors adversely affected the compound's in vivo activity.
Aligned microcontact printing of micrometer-scale poly-L-Lysine structures for controlled growth of cultured neurons on planar microelectrode arrays (2000)

We describe a method for producing high-resolution chemical patterns on surfaces to control the attachment and growth of cultured neurons. Microcontact printing has been extended to allow the printing of /spl mu/m-scale protein lines aligned to an underlying pattern of planar microelectrodes. Poly-L-lysine (PL) lines have been printed on the electrode array for electrical studies on cultured neural networks. Rat hippocampal neurons showed degree of attachment selectivity to the PL and produced neurites that faithfully grew onto the electrode recording sites.
Layer‐by‐Layer Platform Technology for Small‐Molecule Delivery (2009)

Flexible delivery vehicle: Layer-by-layer assembly and supramolecular chemistry were used to create an ultrathin-film platform technology for small-molecule delivery using a hydrolytically degradable polyion (see picture, blue waves) and a polymeric cyclodextrin (see picture, red cups).
Phase I/II Pilot Study of Intravesical Apaziquone (EO9) for Superficial Bladder Cancer (2006)

Intravesical administration of 4 mg/40 ml apaziquone was well tolerated and had ablative activity against superficial bladder cancer marker lesions.
Characterization of a Domain of a Human Type I Interferon Receptor Protein Involved in Ligand Binding (1995)

Two monoclonal antibodies that recognize different epitopes of the extracellular domain of one of the proteins that constitute the type I interferon receptor were used to delineate the interferon binding site. Antibody 64G12 both inhibits the binding of radiolabeled interferon-alpha 2 and IFN-alpha 8 to their cell surface receptors and neutralizes the antiviral and antiproliferative actions of all the type I interferons tested, including IFN-beta, IFN-omega, and human leukocyte IFN, a mixture of different interferon-alpha isotypes. Antibody 34F10 recognizes the type I interferon receptor with an affinity similar to that of the MAb 64G12 but does not inhibit either the binding or the biologic activity of any of the type I interferons tested. Both antibodies recognize a protein of 105 +/- 5 kD from either Daudi or Ly28 cells. Immunoprecipitation following surface iodination demonstrated that the neutralizing MAb recognizes a protein of 105 kD and the nonneutralizing MAb a protein of 110 kD in extracts of Daudi cells. A second less intense band was also detected by both antibodies. Cross-linking of IFN-alpha 2 to its receptor before immunoprecipitation prevented the neutralizing antibody from immunoprecipitating the receptor protein, but the nonneutralizing MAb was still able to recognize a 140 kD protein corresponding to the cross-linked interferon-receptor protein complex. Thus, an interferon binding domain appears to be localized in a region between amino acids 23 and 229 of the extracellular domain of a transmembrane protein that forms part of the type I interferon receptor complex containing the epitopes recognized by each antibody.
A scanned beam THz imaging system for medical applications (2011)

THz medical imaging has been a topic of increased interest recently due largely to improvements in source and detector technology and the identification of suitable applications. One aspect of THz medical imaging research not often adequately addressed is pixel acquisition rate and phenomenology. The majority of active THz imaging systems use translation stages to raster scan a sample beneath a fixed THz beam. While these techniques have produced high resolution images of characterization targets and animal models they do not scale well to human imaging where clinicians are unwilling to place patients on large translation stages. This paper presents a scanned beam THz imaging system that can acquire a 1 cm<sup>2</sup> area with 1 mm<sup>2</sup> pixels and a per-pixel SNR of 40 dB in less than 5 seconds. The system translates a focused THz beam across a stationary target using a spinning polygonal mirror and HDPE objective lens. The illumination is centered at 525 GHz with ~ 125 GHz of response normalized bandwidth and the component layout is designed to optically co-locate the stationary source and detector ensuring normal incidence across a 50 mm &times; 50 mm field of view at standoff of 190 mm. Component characterization and images of a test target are presented. These results are some of the first ever reported for a short standoff, high resolution, scanned beam THz imaging system and represent an important step forward for practical integration of THz medical imaging where fast image acquisition times and stationary targets (patients) are requisite.
Radiation sensitisation by nitric oxide releasing agents. (1996)

Previous studies have shown that nitric oxide (NO) sensitises hypoxic cells to ionising radiation. In the present study, four different nitric oxide (NO) donor agents were evaluated for both NO release and hypoxic radiosensitisation. The S-nitrosothiol NO donor agents, S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylpenicillamine (SNAP), were shown to release sustained NO concentrations (microM) and significantly radiosensitise hypoxic cells. The extent of hypoxic radiosensitisation by both of these agents at 1.0 mM concentration was similar to that obtained with molecular oxygen. In contrast, neither 3-morpholinosydnonimine (SIN-1) nor sodium nitroprusside (SNP) released detectable NO concentrations and neither agent enhanced the hypoxic radiation response to the extent of that observed for GSNO or SNAP. NO-mediated hypoxic cell radiosensitisation by NO donor drugs may offer a new approach for clinical consideration, particularly if such agents can be selectively delivered to hypoxic cells.
Osteoprotegerin diminishes advanced bone cancer pain. (2001)

Bone cancer pain most commonly occurs when tumors originating in breast, prostate, or lung metastasize to long bones, spinal vertebrae, and/or pelvis. Primary and metastatic cancers involving bone account for approximately 400,000 new cancer cases per year in the United States alone, and >70% of patients with advanced breast or prostate cancer have skeletal metastases. Whereas pain resulting from bone cancer can dramatically impact an individual's quality of life, very little is known about the mechanisms that generate and maintain this pain. To begin to define the mechanisms that give rise to advanced bone cancer pain, osteolytic 2472 sarcoma cells or media were injected into the intramedullary space of the femur of C3H/HeJ mice, and the injection hole was sealed using dental amalgam, confining the tumor cells to the bone. Twelve days after injection of 2472 tumor cells, animals showed advanced tumor-induced bone destruction of the injected femur, bone cancer pain, and a stereotypic set of neurochemical changes in the spinal cord dorsal horn that receives sensory inputs from the affected femur. Administration of osteoprotegerin, a naturally secreted decoy receptor that inhibits osteoclast maturation and activity and induces osteoclast apoptosis, or vehicle was begun at 12 days, when significant bone destruction had already occurred, and administration was continued daily until day 21. Ongoing pain behaviors, movement-evoked pain behaviors, and bone destruction were assessed on days 10, 12, 14, 17, and 21. The neurochemistry of the spinal cord was evaluated at days 12 and 21. Results indicated that osteoprotegerin treatment halted further bone destruction, reduced ongoing and movement-evoked pain, and reversed several aspects of the neurochemical reorganization of the spinal cord. Thus, even in advanced stages of bone cancer, ongoing osteoclast activity appears to be involved in the generation and maintenance of ongoing and movement-evoked pain. Blockade of ongoing osteoclast activity appears to have the potential to reduce bone cancer pain in patients with advanced tumor-induced bone destruction.