gebhart/patrepeval huggingface dataset:
The biological significance of nitric oxide formation from l-arginine (1989)

Conference Article| August 01 1989 The biological significance of nitric oxide formation from l-arginine SALVADOR MONCADA; SALVADOR MONCADA 1The Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar RICHARD M. J. PALMER; RICHARD M. J. PALMER 1The Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar E. ANNIE HIGGS E. ANNIE HIGGS 1The Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1989) 17 (4): 642–644. https://doi.org/10.1042/bst0170642 Article history Received: February 06 1989 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation SALVADOR MONCADA, RICHARD M. J. PALMER, E. ANNIE HIGGS; The biological significance of nitric oxide formation from l-arginine. Biochem Soc Trans 1 August 1989; 17 (4): 642–644. doi: https://doi.org/10.1042/bst0170642 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: EDRF, endothelium-derived relaxing factor, L-NMMA, NG-monomethyl L-arginine, ACh, acetylcholine, LPS, lipopolysaccharide, NMDA, N-methyl-D-aspartate, NO, nitric oxide This content is only available as a PDF. © 1989 Biochemical Society1989 Article PDF first page preview Close Modal You do not currently have access to this content.
Bilateral Carotid Endarterectomy with Attempted Preservation of Carotid Body Function (1972)

Hickey, Robert F. M.D.; Ehrenfeld, William K. M.D., F.F.C.S.; Hamilton, F. Norman M.D.; Labson, C. Philip Jr M.D. Author Information
Critical Care Management of a Severe Acute Respiratory Distress Syndrome COVID-19 Patient With Control Cesarean Section (2022)

We share our experience of one 29-year-old female, G2 P1, with acute respiratory distress syndrome (ARDS) and at 30 weeks of pregnancy. The 30-week gravid uterus in combination with a poor ventilation-perfusion ratio creates a restrictive lung pattern that may prove to be lethal for both the mother and baby. Due to her rapid deterioration and increased hemodynamic instability we opted for controlled delivery in the operating room with an ICU physician, a Neonatologist, and an Obstetric team. At 3.27 minutes from induction, the baby was born with Apgar scores of 7 and 8. The mother was placed on a RotoProne® bed, treated with remdesivir, steroids, and was subsequently extubated seven days later. The newborn was admitted to the Neonatal Intensive Care Unit (NICU) after delivery. We have reviewed the literature and provided a concise set of recommendations based on our field experience and current world literature review. Prompt delivery in a controlled environment with multiple resuscitating teams provided expeditious treatment of both patients, maintaining oxygenation and perfusion while keeping hemodynamic stability. The controlled environment and the proximity of all teams avoided deleterious consequences to the unborn baby. This is an example where the risk of keeping the baby in the womb outweighs the premature delivery into a NICU. Both mother and baby were downgraded from their respective Intensive Care Units (ICUs) and discharged home in one month.
On the geometry of differential privacy (2010)

We consider the noise complexity of differentially private mechanisms in the setting where the user asks d linear queries f:Rn -> R non-adaptively. Here, the database is represented by a vector in R and proximity between databases is measured in the l1-metric. We show that the noise complexity is determined by two geometric parameters associated with the set of queries. We use this connection to give tight upper and lower bounds on the noise complexity for any d ≤ n. We show that for d random linear queries of sensitivity 1, it is necessary and sufficient to add l2-error Θ(min d√d/ε,d√(log (n/d))/ε) to achieve ε-differential privacy. Assuming the truth of a deep conjecture from convex geometry, known as the Hyperplane conjecture, we can extend our results to arbitrary linear queries giving nearly matching upper and lower bounds.
<title>Model-based color image quantization</title> (1993)

In this paper, we propose a new technique for halftoning color images. Our technique parallels recent work in model-based halftoning for both monochrome and color images; we incorporate a human visual model that accounts for the difference in the responses of the human viewer to luminance and chrominance information. Thus, the RGB color space must be transformed to a luminance/chrominance based color space. The color transformation we use is a linearization of the uniform color space L<SUP>*</SUP>a<SUP>*</SUP> b<SUP>*</SUP> which also decouples changes between the luminance and chrominance components. After deriving a tractable expression for total- squared perceived error, we then apply the method of Iterated Conditional Modes (ICM) to iteratively toggle halftone values and exploit several degrees of freedom in reducing the perceived error as predicted by the model.
Visual teach and repeat for long‐range rover autonomy (2010)

Abstract This paper describes a system built to enable long‐range rover autonomy using a stereo camera as the only sensor. During a learning phase, the system builds a manifold map of overlapping submaps as it is piloted along a route. The map is then used for localization as the rover repeats the route autonomously. The use of local submaps allows the rover to faithfully repeat long routes without the need for an accurate global reconstruction. Path following over nonplanar terrain is handled by performing localization in three dimensions and then projecting this down to a local ground plane associated with the current submap to perform path tracking. We have tested this system in an urban area and in a planetary analog setting in the Canadian High Arctic. More than 32 km was covered—99.6% autonomously—with autonomous runs ranging from 45 m to 3.2 km, all without the use of the global positioning system (GPS). Because it enables long‐range autonomous behavior in a single command cycle, visual teach and repeat is well suited to planetary applications, such as Mars sample return, in which no GPS is available. © 2010 Wiley Periodicals, Inc.
Isolation of polymorphic DNA fragments from human chromosome 4 (1987)

A somatic cell hybrid line containing only human chromosome 21 on a mouse background has been used as the source of DNA for construction of a recombinant phage library. Individual phages containing human inserts have been identified. Repeat-free human DNA subclones have been prepared and used to screen for restriction fragment length polymorphisms to provide genetic markers on chromosome 21. Nine independently isolated clones used as probes identified a total of 11 new RFLPs. Four of the DNA probes recovered from the library have been mapped unequivocally to chromosome 21 using a panel of somatic cell hybrid lines. A fifth probe detected an RFLP on chromosome 21 as well as sequences on other chromosomes. This set of RFLPs may now form the basis for construction of a genetic linkage map of human chromosome 21.
Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles (2006)

In connection with an ongoing investigation of indenoisoquinoline topoisomerase I (Top1) inhibitors as potential therapeutic agents, the pharmacophore possessing di(methoxy) and methylenedioxy substituents was held constant, and new derivatives were synthesized with nitrogen heterocycles appended to the lactam side chain. Compounds were evaluated for Top1 inhibition and for cytotoxicity in the National Cancer Institute's human cancer cell screen. Some of the more potent derivatives were also screened for in vivo activity in a hollow fiber assay. The results of these studies indicate that lactam substituents possessing nitrogen heterocycles can provide highly cytotoxic compounds with potent Top1 inhibition. Molecular modeling of these compounds in complex with DNA and Top1 suggests that some of the lactam substituents are capable of interacting with the DNA base pairs above and below the site of intercalation and/or with Top1 amino acid residues, resulting in increased biological activity.
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design (2018)

The electronic properties and relatively small size of fluorine endow it with considerable versatility as a bioisostere and it has found application as a substitute for lone pairs of electrons, the hydrogen atom, and the methyl group while also acting as a functional mimetic of the carbonyl, carbinol, and nitrile moieties. In this context, fluorine substitution can influence the potency, conformation, metabolism, membrane permeability, and P-gp recognition of a molecule and temper inhibition of the hERG channel by basic amines. However, as a consequence of the unique properties of fluorine, it features prominently in the design of higher order structural metaphors that are more esoteric in their conception and which reflect a more sophisticated molecular construction that broadens biological mimesis. In this Perspective, applications of fluorine in the construction of bioisosteric elements designed to enhance the in vitro and in vivo properties of a molecule are summarized.
Notas a una obra inconclusa. Aproximación a Tientos de Tierra Llana, para guitarra. (2010)

espanolEste documento analiza la obra Tientos de Tierra Llana del maestro Samuel Bedoya (Medellin 1947 - Bogota 1994), coleccion de golpes llaneros tradicionales compuestos entre 1977 y 1978. Este trabajo es el fruto de la labor de investigacion en torno a las musicas regionales de Colombia, unido a su intencion didactica para difundir estos sonidos. El maestro buscaba la recopilacion, adaptacion y catalogacion de los golpes, concentrandose en sus aspectos formales, estructurales y estilisticos para enriquecer la literatura del instrumento y favorecer los procesos formativos de los nuevos guitarristas. A su vez, esta obra formaba parte de un extenso plan de produccion que no pudo culminar. EnglishThis article analyzes the piece Tientos de Tierra Llana, written by the musician Samuel Bedoya (Medellin 1947 - Bogota 1994). It is a collection of traditional golpes llaneros written in 1977 and 1978. This work is the result of the research about regional musics of Colombia, together with the didactic goal to difuse these sounds. The maestro Bedoya tried to enrich the available literature for guitar as well as to favour the formation processes of new guitar students by collecting, adapting and documenting the golpes, focusing on the formal, structural and stylistic forms. Unfortunately, this piece is part of a bigger production plan maestro Bedoya could not finish.
Stress-Dependent Permeability: Characterization and Modeling (1999)

Abstract During the production lifecycle of a reservoir, absolute permeability at any given location may change in response to an increase in the net effective stress and a concomitant decrease in the value of in-situ permeability. This paper focuses stress dependent permeability in unconsolidated, high porosity sand reservoirs (offshore turbidites) and consolidated reservoirs (tight gas sands). Specifically we address: i) fundamental controls on stress dependent permeability, as identified through analysis of core samples, ii) rock-based log modeling of stress dependent permeability in cored and non-cored wells, and iii) implications for production based on data from reservoir simulation. This work reveals a fundamental difference between the stress dependent permeability behavior of unconsolidated and consolidated sand reservoirs. In unconsolidated sand reservoirs, the greatest permeability reduction with stress occurs in the sands with the highest values of porosity and permeability. In cemented sandstone reservoirs, the opposite is the case: most of the reduction in permeability occurs in sandstones with the lowest values of porosity and permeability. This difference in behavior between unconsolidated and consolidated reservoir sands is controlled by pore geometry. We present a practical, rapid and cost efficient methodology to improve evaluation and enhance the productivity and management of stress-dependent reservoirs. The method is based fundamentally on the identification of ΑRock Types≅ (intervals of rock with unique pore geometry). Thin section evaluation, together with integrated nuclear magnetic resonance and SEM-based image analysis of core material is used to quantitatively identify various Rock Types. Rock Type data is integrated with measurements of permeability at various levels of stress. Results demonstrate that, within a particular field, some Rock Types lose &amp;lt;10% of original permeability while others lose &amp;gt;90% of original permeability as a function of increasing stress. Rock Types are then identified using routine suites of wireline logs, allowing for field-wide determination of the net footage and distribution of each Rock Type in all wells and the foot-by-foot calculation of permeability at any value of net effective stress. Based on geological input, the reservoirs are divided into flow units (hydrodynamically continuous layers) and grid blocks for simulation. Several cases are presented of a conceptual, single well model of an overpressured, tight gas sandstone reservoir that include stress dependent permeability. Results of simulation analyses for varying conditions of reservoir stress demonstrate the importance of stress dependent permeability in more accurate forecasting of reserves and predicting optimum well bore producing conditions.
A multi-fiber ring architecture for distributed lightwave networks (2003)

A lightwave packet network architecture suitable for local applications (office, campus, and metropolitan areas) is proposed and analyzed. In describing the architecture, careful distinction is made between the physical topology depicting the physical-link arrangement and the connectivity graph showing logical connections among various nodes. Also emphasized are the practicality of implementation, cost, and upward compatibility with future technology. The physical layout of the network is based on a multifiber ring whereby a cable consisting of multiple fibers is deployed as a passive interconnect fabric for the entire network. A node is connected into the network by intercepting three fibers in the cable and inserting it between the cut fibers. Packets received are examined for their destination addresses and judiciously routed to the appropriate outbound lines or the local exit. To support a network of N nodes, the number of fibers required in the bundle is only square root N+4. This is a result of employing a specific connectivity graph in which the N nodes are arranged in a square root N* square root N grid structure with both crossbar and criss-cross (diagonal) connections.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Evidence for Multiple Genetic Susceptibility Loci for Asthma (1997)

Genetic susceptibility to asthma is due to multiple genes that interact with each other and the environment. There are many known environmental influences, such as viral and other respiratory infections and exposure to allergens, air pollutants, and active or passive cigarette smoke (1). Genome-wide screens for asthma and atopy have been completed and show statistical evidence for linkage in different racial groups and population samples (4, 5). Some of these linkages have already been replicated in different studies, and most of them are in chromosomal regions containing relevant candidate genes that may regulate inflammatory processes including cytokine synthesis, T-cell responses, or other immune functions. These associations support the relevance of this genetic approach in understanding susceptibility to and expression of asthmatic and allergic phenotypes. Once specific sequence variants are identified, it will become important to test for gene-environment interaction in order to understand the significance and relative effect of each gene on the overall phenotype.
Detection of heat shock protein 70 (HSP70) and anti-HSP70 antibodies in the serum of normal individuals (1998)

Heat shock or stress proteins (Hsp) are typically regarded as being intracellular proteins that have a range of functions including the maintenance of cellular integrity. Members of the Hsp70 family of molecules have been implicated in the processing and presentation of antigen and the cross reactivity of lymphocytes specific for pathogen-derived heat shock proteins with self Hsp70 has been suggested to be an underlying cause of certain autoimmune diseases. This study reports the presence of soluble Hsp70 in the peripheral circulation of normal individuals. Concentrations of soluble Hsp70 in females were approximately twice those in males. Circulating anti-Hsp70 antibodies were detected in all individuals assessed, but there were no differences between males and females. However, there was a significant correlation between soluble Hsp70 concentration and antibody levels in males, but not females. The physiological role for circulating heat shock proteins is intriguing, but currently unknown. These findings extend our previous observations that Hsp60 is present in the peripheral circulation and support the proposition that soluble heat shock proteins may play a regulatory role in either the prevention or protection of pathophysiological processes involving inadvertent immunorecognition or cross-recognition of heat shock proteins.
Bacterial cell wall-induced hepatic granulomas. An in vivo model of T cell-dependent fibrosis. (1986)

In vitro studies implicate a molecular link between inflammatory mononuclear cells and alterations in fibroblast growth and function. We have extended these observations in an experimental animal model in which we document the T cell-dependence of fibrosis that occurs after activation of the cell-mediated immune system by specific antigen. Chronic granulomatous lesions were induced in the livers of susceptible rats by the intraperitoneal injection of group A streptococcal cell walls (SCW). The development of granulomas that are composed primarily of lymphocytes and macrophages was associated with the recruitment and proliferation of connective tissue cells. Furthermore, this expanded population of fibroblasts generated a collagenous structure consisting primarily of types I and III collagen around the granuloma. The progression of these chronic inflammatory lesions leads to the formation of fibrotic nodules throughout the livers of the treated animals. Intact granulomas, as well as mononuclear cells derived from the granulomas, spontaneously elaborated a soluble factor(s) that stimulates fibroblast proliferation. Physicochemical analysis revealed that the primary granuloma-derived peak of fibroblast growth activity corresponded to an apparent Mr of 40,000, which is consistent with a previously described T lymphocyte--derived fibroblast-activating factor (FAF) in guinea pig and human. Furthermore, the fibrosis that occurs in the granuloma is apparently T cell--dependent, since no fibrotic lesions developed in SCW-injected athymic nude rats nor in SCW-injected animals treated with the T cell inhibitor, cyclosporin A (CsA). Mononuclear cells from neither of these functionally T cell--deficient animals could generate FAF activity. These data show a role for T lymphocyte--derived cytokines in the development of hepatic fibrosis in SCW-injected rats.
Communication systems using bundle conductor overhead power lines (1975)

The main properties of power line carrier (p.l.c.) systems, used conventionally for internal communication purposes in electricity supply undertakings, are examined, and an alternative method for use on bundle-conductor lines is proposed. Earlier work, departing from the use of conventional phase-ground or interphase carrier, proposed the electrical separation of the subconductors of a bundle for signal frequencies, but retained the remaining aspects of conventional p.l.c. These include particularly the expensive filter components required to limit the signal, as far as possible, to the desired parts of the power network, together with the frequency and bandwidth limitation imposed on the signal by these filters. The intrabundle communication system proposed uses a simple, inexpensive but highly efficient broadband coupling method which permits signal-isolation between subconductors without inserting additional impedance at power frequency or reducing the power transmission capability of the line. The signal characteristics of the new system are such that interference is reduced by orders of magnitude in comparison to p.l.c., avoiding need for frequency assignment even between adjacent phases. A bandwidth of 1.6 MHz is available. This may be exploited in a variety of ways, including the transmission of data at faster rates, to enhance the reliability and speed of protection signalling, or to provide up to 180 duplex voice channels. Even where one voice channel only is required, the cost of an intrabundle communication system is estimated to be less than that of a p.l.c, system for route lengths of at least 29 km, and allows subsequent increase in the voice channel numbers at low extra cost.