gebhart/patrepeval huggingface dataset:
Probability grid: a location estimation scheme for wireless sensor networks (2005)

Location information is of paramount importance for wireless sensor networks (WSN). The accuracy of the collected data can significantly be affected by an imprecise positioning of the event of interest. Despite the importance of location information, real system implementations that do not use specialized hardware for localization purposes have not been successful. In this paper, we propose a location estimation scheme that uses a probabilistic approach for estimating the location of a node in a sensor network. Our localization scheme makes use of additional knowledge of topology deployment. We assume a sensor network is deployed in a controlled manner, where the goal of the deployment is to form a grid topology. We evaluate our localization scheme through simulations, showing localization errors as low as 3% of radio range. We outperform similar localization schemes by obtaining 50% less error in localization. We also evaluate our localization solution and the DV-hop scheme in a real implementation, obtaining an average error in location of 79% of radio range, outperforming DV-hop by approximately 40%. We analyze the significant differences in performance between simulations and a real implementation and stress the importance of further evaluations of real implementations. The result is an effective and realistic protocol that works in an actual implementation, under certain assumptions, because it exploits deployment information.
Constitutional WT1 mutations in Wilms' tumor patients. (1998)

Germline WT1 mutations in patients with WT are associated with genitourinary anomalies, especially cryptorchidism and/or hypospadias. Patients with WT and no genitourinary anomalies are at low risk for carrying a WT1 mutation. Constitutional WT1 mutations that encode truncated WT1 proteins may predispose to the development of cryptorchidism, hypospadias, and WTs.
A comparative study of behavior problems in children of schizophrenic patients (1999)

Objective The purpose of this study was to explore the differences of behavior problems andthe influential factors between children of schizophrenics and those of normal controls. Methods One hundred andeight children of schizophrenic patients and 108 children of normal parents were investigated using Achenbach ChildBehavior Check List (ACBL). The general information such as family rearing styes and school performances werealso collected. Results The rate of behavior problems among the children of schizophrenic patients was 32. 5 %,which was higher than that of normal controls (11. 1 % ). The average CBCL score in the children of schizophrenicpatients was 26.32±9.35, which was higher than that of normal contros (9.22±5.65; t =16.27, P＜0.01).The family rearing styles and school performances of children also showed significant differences between twogroups. Conclusions The child rearing style of schizophrnics families glays an important role in their children'behavior problems.
Adaptive ranging for optical coherence tomography (2004)

At present, optical coherence tomography systems have a limited imaging depth or axial scan range, making diagnosis of large diameter arterial vessels and hollow organs difficult. Adaptive ranging is a feedback technique where image data is utilized to adjust the coherence gate offset and range. In this paper, we demonstrate an adaptive optical coherence tomography system with a 7.0 mm range. By matching the imaging depth to the approximately 1.5 mm penetration depth in tissue, a 3 dB sensitivity improvement over conventional imaging systems with a 3.0 mm imaging depth was realized.
Gabriel Hanotaux dir. Histoire de la nation française, t. IV (1924)

Marcel Louis. Gabriel Hanotaux dir. Histoire de la nation française, t. IV. In: Revue d'histoire de l'Église de France, tome 10, n°49, 1924. pp. 514-516.
PREMIO MARÍA LAVALLE URBINA (2001)

GR FICA DE LA ENTREGA DEL PREMIO MARIA LAVALLE URBINA, QUE RECIBIERON GLORIA ORNELAS HALL Y RAQUEL GERSON CWILICH POR SU DESEMPENO EN LA INVESTIGACION Y TRATAMIENTO DEL SIDA Y C NCER, RESPECTIVAMENTE.
BINDING OF A PORPHYRIN CONJUGATE OF HOECHST 33258 TO DNA. II. NMR SPECTROSCOPIC STUDIES DETECT MULTIPLE BINDING MODES TO A 12-MER NONSELF-COMPLEMENTARY DUPLEX DNA (2001)

We have probed by 1H NMR spectroscopy the molecular basis of the interaction between Hoechst 33258 conjugated to a des-metalloporphyrin and a non self-complementary duplex DNA sequence, designed on the known chemical nuclease selectivity of this system. The imino NMR spectra are consistent with two distinct families of structure, that is, PORHOE binding either way along the duplex. 2D spectral, T2, and linewidth data suggest multiple species within the two conformational families.
Fast query by example of environmental sounds via robust and efficient cluster-based indexing (2008)

There has been much recent progress in the technical infrastructure necessary to continuously characterize and archive all sounds, or more precisely auditory streams, that occur within a given space or human life. Efficient and intuitive access, however, remains a considerable challenge. In specifically musical domains, i.e., melody retrieval, query-by-example (QBE) has found considerable success in accessing music that matches a specific query. We propose an extension of the QBE paradigm to the broad class of natural and environmental sounds, which occur frequently in continuous recordings. We explore several cluster-based indexing approaches, namely non-negative matrix factorization (NMF) and spectral clustering to efficiently organize and quickly retrieve archived audio using the QBE paradigm. Experiments on a test database compare the performance of the different clustering algorithms in terms of recall, precision, and computational complexity. Initial results indicate significant improvements over both exhaustive search schemes and traditional K- means clustering, and excellent overall performance in the example-based retrieval of environmental sounds.
Reporter Affinity Labels:  An o-Phthalaldehyde Derivative of β-Naltrexamine as a Fluorogenic Ligand for Opioid Receptors (2000)

ADVERTISEMENT RETURN TO ISSUELetterNEXTReporter Affinity Labels: An o-Phthalaldehyde Derivative of β-Naltrexamine as a Fluorogenic Ligand for Opioid ReceptorsBertrand Le Bourdonnec, Rachid El Kouhen, Mary M. Lunzer, Ping Y. Law, Horace H. Loh, and Philip S. PortogheseView Author Information Department of Medicinal Chemistry, College of Pharmacy, and Department of Pharmacology, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55455 Cite this: J. Med. Chem. 2000, 43, 13, 2489–2492Publication Date (Web):June 10, 2000Publication History Received23 March 2000Published online10 June 2000Published inissue 1 June 2000https://pubs.acs.org/doi/10.1021/jm000138shttps://doi.org/10.1021/jm000138srapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views634Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Fluorescence,Ligands,Monomers,Peptides and proteins,Receptors Get e-Alerts
Lateral Hopping of Molecules Induced by Excitation of Internal Vibration Mode (2002)

We demonstrate electron-stimulated migration for carbon monoxide (CO) molecules adsorbed on the Pd(110) surface, which is initiated by the excitation of a high-frequency (HF) vibrational mode (C-O stretching mode) with inelastic tunneling electrons from the tip of scanning tunneling microscopy. The hopping phenomenon, however, cannot be detected for CO/Cu(110), even though the hopping barrier is lower than in the CO/Pd(110) case. A theoretical model, which is based on the anharmonic coupling between low-frequency modes (the hindered-translational mode related to the lateral hopping) and the HF mode combined with electron-hole pair excitation, can explain why the hopping of CO is observed on Pd(110) but not on Cu(110).
Modeling focus of attention for meeting indexing based on multiple cues (2002)

A user's focus of attention plays an important role in human-computer interaction applications, such as a ubiquitous computing environment and intelligent space, where the user's goal and intent have to be continuously monitored. We are interested in modeling people's focus of attention in a meeting situation. We propose to model participants' focus of attention from multiple cues. We have developed a system to estimate participants' focus of attention from gaze directions and sound sources. We employ an omnidirectional camera to simultaneously track participants' faces around a meeting table and use neural networks to estimate their head poses. In addition, we use microphones to detect who is speaking. The system predicts participants' focus of attention from acoustic and visual information separately. The system then combines the output of the audio- and video-based focus of attention predictors. We have evaluated the system using the data from three recorded meetings. The acoustic information has provided 8% relative error reduction on average compared to only using one modality. The focus of attention model can be used as an index for a multimedia meeting record. It can also be used for analyzing a meeting.
Evaluation of Adeno-Associated Viral Vectors for Liver-Directed Gene Transfer in Dogs (2011)

This study evaluated six adeno-associated viral (AAV) vectors expressing green fluorescent protein (GFP) from the liver-specific thyroid hormone-binding globulin (TBG) promoter made with novel capsids in canine liver-directed gene transfer. Studies in 1.5-month-old dogs, which were administered vector through a peripheral vein, showed that AAV8 capsid vectors had the most favorable performance profiles. Interestingly, the absolute levels of hepatocyte transduction achieved with AAV8 were lower in dogs compared with what had been achieved in mice and nonhuman primates. Additional studies were performed with AAV8 delivered into the hepatic artery in adult dogs, with higher doses of vector used to assess potential dose-limiting toxicities. These studies showed good transduction on day 7 in one dog that apparently was lost by day 28 in another dog through the generation of GFP-specific T cells. Each adult dog was carefully monitored for any hemodynamic changes associated with vector infusion. Both animals demonstrated mild to moderate hypotension and bradycardia, which appeared to be anesthesia-related, making it difficult to evaluate contributions of the vector.
Enhancement of Sindbis Virus Self-Replicating RNA Vaccine Potency by Linkage of Herpes Simplex Virus Type 1 VP22 Protein to Antigen (2001)

Recently, self-replicating and self-limiting RNA vaccines (RNA replicons) have emerged as an important form of nucleic acid vaccines. Self-replicating RNA eventually causes lysis of transfected cells and does not raise the concern associated with naked DNA vaccines of integration into the host genome. This is particularly important for development of vaccines targeting proteins that are potentially oncogenic. However, the potency of RNA replicons is significantly limited by their lack of intrinsic ability to spread in vivo. The herpes simplex virus type 1 protein VP22 has demonstrated the remarkable property of intercellular transport and provides the opportunity to enhance RNA replicon vaccine potency. We therefore created a novel fusion of VP22 with a model tumor antigen, human papillomavirus type 16 E7, in a Sindbis virus RNA replicon vector. The linkage of VP22 with E7 resulted in a significant enhancement of E7-specific CD8+ T-cell activities in vaccinated mice and converted a less effective RNA replicon vaccine into one with significant potency against E7-expressing tumors. These results indicate that fusion of VP22 to an antigen gene may greatly enhance the potency of RNA replicon vaccines.
Solubility and Solubilization in Aqueous Media (1999)

This book aims to provide the reader with a working knowledge of the various means of controlling the solubility or dissolution rate of a drug or other solute in an aqueous medium. The book begins with the factors which govern solubility in general and then looks at aqueous solubility in particular, including the properties of liquid mixtures and the thermodynamics of solutions formed from mixing two components. The bulk of the book is then devoted to techniques for altering solubility and dissolution rate of organic compounds in aqueous media. It discusses in detail the most commonly used solubility enhancers: buffers, co-solvents, surfactants, and complexants. Each chapter is self-contained and emphasizes the details for applying the techniques.
Breeding behaviour of a stallion at pasture with 20 mares in synchronized oestrus. (1982)

A 6-year-old stallion was placed in a pasture for 9 days with 20 mares in which oestrus was synchronized with two treatments of PGF-2 alpha given 15 days apart. Breeding and observation began 3 days after the second treatment. Observations were carried out during the daylight hours (05:00 to 21:30 h). Eighteen mares showed oestrus and mated an average of 4.56 times each (range 1-12). There were 1.74 mounts per mating. The maximum number of matings by the stallion during 1 day was 16 on Day 2. The overall mean interval between matings was 72.8 min, ranging from 34.5 min on Day 1 to 128.7 on Day 6. The mares were mated at irregular intervals during oestrus but 16 of 18 (88.9%) mares mated at least once during the 3 days preceding the last day of oestrus. Only 5 mares mated on the last day of oestrus. Of the 20 mares, 17 (85%) were pregnant when examined 38 days after the end of the experiment. The results suggest that a stallion will indulge in significantly more mating activity at pasture than is currently expected with hand mating and still achieve a high first oestrus conception rate.
RNA Splicing Manipulation: Strategies to Modify Gene Expression for a Variety of Therapeutic Outcomes (2005)

Antisense oligomers initially showed promise as compounds to modify gene expression, primarily through RNaseH induced degradation of the target transcript. Expansion of the field has led to new chemistries capable of invoking different mechanisms, including suppression of protein synthesis by translational blockade and gene silencing using short interfering RNAs. It is now apparent that the majority of the eukaryotic genome is transcribed and non-protein coding RNAs have been implicated in the regulation of gene expression at many levels. This review considers potential therapeutic applications of antisense oligomers to modify gene expression, primarily by interfering with the process of exon recognition and intron removal during gene transcript splicing. While suppression of gene expression will be necessary to address some conditions, it is likely that antisense oligomer splice modification will have extensive clinical application. Pre-mRNA splicing is a tightly co-ordinated, multifactorial process that can be disrupted by antisense oligomers in a highly specific manner to suppress aberrant splicing, remove exons to by-pass nonsense or frame-shifting mutations or influence exon selection to alter spliceoform ratios. Manipulation of splicing patterns has been applied to a diverse range of conditions, including b-thalassemia, Duchenne muscular dystrophy, spinal muscular atrophy and certain cancers. Alternative exon usage has been identified as a major mechanism for generating diversity from a limited repertoire of genes in higher eukaryotes. Considering that the majority of all human primary gene transcripts are reportedly alternatively spliced, intervention at the level of pre-mRNA processing is likely to become increasingly significant in the fight against genetic and acquired disorders.
Temperature control of growth and productivity in mutant Chinese hamster ovary cells synthesizing a recombinant protein (1993)

The use of a temperature switch to control the growth and productivity of temperature-sensitive (ts) mutants was investigated to extend the productive life span of recombinant Chinese hamster ovary (CHO) cells in batch culture. Bromodeoxyuridine was used at 39 degrees C to select mutagenized CHO-K1 cells, which resulted in the isolation of 31 temperature-sensitive mutants that were growth inhibited at 39 degrees C. Two of these mutants were successfully transfected with the gene for tissue inhibitor of metalloproteinases (TIMP) using glutamine synthetase amplification, and a permanent recombinant cell line established (5G1-B1) that maintains the ts phenotype.Continuous exposure to the nonpermissive temperature (npt) of 39 degrees C led to a rapid decline in cell viability. However, a temperature regime using alternating incubations at 34 degrees C and 39 degrees C arrested the 5G1-B1 cells while retaining a high cell viability for up to 170 h in culture. The specific production rate of the growth-arrested cells was 3-4 times that of control cultures maintained at a constant 34 degrees C over the crucial 72-130-h period of culture, which resulted in a 35% increase in the maximum product yield. Glucose uptake and lactate production both decreased in arrested cells. Flow cytometric analysis indicated that 5G1-B1 cells arrested in the G(1) or G(0) phase of the cell cycle, and no major structural damage was caused to these cells by the alternating temperature regime.These results demonstrate that growth-arrested ts CHO cells have increased productivity compared to growing cultures and maintain viability for longer periods. The system offers the prospect of enhancing the productivity of recombinant mammalian cells grown in simple batch fermentors.
Systemic Capillary Leak Syndrome as an Initial Presentation of ALK-Negative Anaplastic Large Cell Lymphoma (2012)

Systemic capillary leak syndrome (SCLS) is a rare disease characterized by third spacing of plasma into the extravascular compartment, leading to anasarca, hemoconcentration, and hypovolemic shock. It has been rarely associated with lymphomas, and reports usually indicate that it occurs after antineoplastic treatment. We present the case of a patient with ALK-negative anaplastic large cell lymphoma who presented with SCLS as the initial manifestation of her lymphoma. The SCLS resolved with treatment of the malignancy with steroids and chemotherapy.
Ratiometric Optical PEBBLE Nanosensors for Real-Time Magnesium Ion Concentrations Inside Viable Cells (2003)

This paper presents the development and characterization of a highly selective magnesium fluorescent optical nanosensor, made possible by PEBBLE (probe encapsulated by biologically localized embedding) technology. A ratiometric sensor has been developed by co-immobilizing a dye that is sensitive to and highly selective for magnesium, with a reference dye in a matrix. The sensors are prepared via a microemulsion polymerization process, which entraps the sensing components inside a polymer matrix. The resultant spherical sensors are approximately 40 nm in diameter. The Coumarin 343 (C343) dye, which by itself does not enter the cell, when immobilized in a PEBBLE is used as the magnesium-selective agent that provides the high and necessary selectivity over other intracellular ions, such as Ca2+, Na+, and K+. The dynamic range of these sensors was 1-30 mM, with a linear range from 1 to 10 mM, with a response time of <4 s. In contrast to free dye, these nano-optodes are not perturbed by proteins. They are fully reversible and exhibit minimal leaching and photobleaching over extended periods of time. In vitro intracellular changes in Mg2+ concentration were monitored in C6 glioma cells, which remained viable after PEBBLE delivery via gene gun injection. The selectivity for Mg2+ along with the biocompatibility of the matrix provides a new and reliable tool for intracellular magnesium measurements.
Beyond Fitts' law (1997)

As a developing discipline, research results in the field of human computer interaction (HCI) tends to be "soft". Many workers in the field have argued that the advancement of HCI lies in "hardening" the field with quantitative and robust models. In reality, few theoretical, quantitative tools are available in user interface research and development. A rare exception to this is Fitts' law. Extending information theory to human perceptual-motor system, Paul Fitts (1954) found a logarithmic relationship that models speed accuracy tradeoffs in aimed movements. A great number of studies have verified and / or applied Fitts' law to HCI problems, such as pointing performance on a screen, making Fitts' law one of the most intensively studied topic in the HCI literature.
Photoelectrochemistry of Films of Quantum Size Lead Sulfide Particles Incorporated in Self-Assembled Monolayers on Gold (1997)

Films of AOT-capped (AOT = dioctyl sulfosuccinate) lead sulfide nanoparticles (Q-PbS) were prepared by incorporation into a self-assembled monolayer of hexanethiol on Au. The Q-PbS particles showed either cathodic or anodic photocurrents, depending on the existence of a hole scavenger or an electron scavenger in the contacting solution, on the state of the surface, and on the electrode potential. The electrochemistry of Q-PbS indicated that the anodic dissolution of Q-PbS occurred at about 0.25 V vs SCE and was not particle size dependent, while the cathodic corrosion potentials of Q-PbS ranged from −1.1 V vs SCE to beyond the hydrogen evolution potential and depended on the size of the Q-PbS particles.
Certificate Management Messages over CMS (2000)

This document defines a Certificate Management protocol using CMS (CMC).This protocol addresses two immediate needs within the Internet PKI community:1.The need for an interface to public key certification products and services based on [CMS] and [PKCS10], and 2. The need in [SMIMEV3] for a certificate enrollment protocol for DSA-signed certificates with Diffie-Hellman public keys.A small number of additional services are defined to supplement the core certificate request service.Throughout this specification the term CMS is used to refer to both [CMS] and [PKCS7].For both signedData and envelopedData, CMS is a superset of the PKCS7.In general, the use of PKCS7 in this document is aligned to the Cryptographic Message Syntax [CMS] that provides a superset of the PKCS7 syntax.The term CMC refers to this specification.