gebhart/patrepeval huggingface dataset:
Conducting Layered Organic-inorganic Halides Containing 〈110〉-Oriented Perovskite Sheets (1995)

Single crystals of the layered organic-inorganic perovskites, [NH(2)C(I=NH(2)](2)(CH(3)NH(3))m SnmI3m+2, were prepared by an aqueous solution growth technique. In contrast to the recently discovered family, (C(4)H(9)NH(3))(2)(CH(3)NH(3))n-1SnnI3n+1, which consists of (100)-terminated perovskite layers, structure determination reveals an unusual structural class with sets of m <110>-oriented CH(3)NH(3)SnI(3) perovskite sheets separated by iodoformamidinium cations. Whereas the m = 2 compound is semiconducting with a band gap of 0.33 +/- 0.05 electron volt, increasing m leads to more metallic character. The ability to control perovskite sheet orientation through the choice of organic cation demonstrates the flexibility provided by organic-inorganic perovskites and adds an important handle for tailoring and understanding lower dimensional transport in layered perovskites.
Influence of cardiac function and failure on sleep-disordered breathing: evidence for a causative role (2005)

Heart failure is an increasingly common public health problem that is strongly linked to both central and obstructive sleep apnea, collectively referred to as sleep-disordered breathing. Much attention has been given to the deleterious effects of sleep-disordered breathing on the failing heart and potential mechanisms by which treatment of sleep-disordered breathing may result in improved cardiac performance and long-term outcomes. However, there is compelling evidence that cardiac dysfunction may contribute to sleep-disordered breathing. Although there is recognized overlap between pathophysiological mechanisms in central sleep apnea and obstructive sleep apnea, data supporting the role of cardiac function are certain forms of central sleep apnea are well established, whereas investigation into the relationship with obstructive sleep apnea is less mature but continues to evolve. This review will examine experimental and observational data that explore possible pathophysiological mechanisms and potential targets for therapy in heart failure and sleep-disordered breathing.
Proteasome-dependent degradation of the human estrogen receptor (1999)

In eukaryotic cells, the ubiquitin-proteasome pathway is the major mechanism for the targeted degradation of proteins with short half-lives. The covalent attachment of ubiquitin to lysine residues of targeted proteins is a signal for the recognition and rapid degradation by the proteasome, a large multi-subunit protease. In this report, we demonstrate that the human estrogen receptor (ER) protein is rapidly degraded in mammalian cells in an estradiol-dependent manner. The treatment of mammalian cells with the proteasome inhibitor MG132 inhibits activity of the proteasome and blocks ER degradation, suggesting that ER protein is turned over through the ubiquitin-proteasome pathway. In addition, we show that in vitro ER degradation depends on ubiquitin-activating E1 enzyme (UBA) and ubiquitin-conjugating E2 enzymes (UBCs), and the proteasome inhibitors MG132 and lactacystin block ER protein degradation in vitro. Furthermore, the UBA/UBCs and proteasome inhibitors promote the accumulation of higher molecular weight forms of ER. The UBA and UBCs, which promote ER degradation in vitro, have no significant effect on human progesterone receptor and human thyroid hormone receptor beta proteins.
Scaling clustering algorithms to large databases (1998)

Practical clustering algorithms require multiple data scans to achieve convergence. For large databases, these scans become prohibitively expensive. We present a scalable clustering framework applicable to a wide class of iterative clustering. We require at most one scan of the database. In this work, the framework is instantiated and numerically justified with the popular K-Means clustering algorithm. The method is based on identifying regions of the data that are compressible, regions that must be maintained in memory, and regions that are discardable. The algorithm operates within the confines of a limited memory buffer. Empirical results demonstrate that the scalable scheme outperforms a sampling-based approach. In our scheme, data resolution is preserved to the extent possible based upon the size of the allocated memory buffer and the fit of current clustering model to the data. The framework is naturally extended to update multiple clustering models simultaneously. We empirically...
Chapter 17—Thermal Properties (1978)

The thermal characteristics of concrete covered in this chapter are: thermal conductivity, specific heat, thermal expansion (or contraction), thermal diffusivity, and heat of hydration of cementitious materials. This last property is included because of its significant influence on the thermal and physical behavior of concrete in most of its uses.
Characterization of β-R1, a Gene That Is Selectively Induced by Interferon β (IFN-β) Compared with IFN-α (1996)

We report preliminary characterization of a gene designated beta-R1, which is selectively expressed in response to interferon beta (IFN-beta) compared with IFN-alpha. In human astrocytoma cells, beta-R1 was induced to an equivalent extent by 10 IU/mL IFN-beta or 2500 IU/mL IFN-alpha2. To address the mechanism of this differential response, we analyzed induction of the beta-R1 gene in fibrosarcoma cells and derivative mutant cells lacking components required for signaling by type I IFNs. beta-R1 was readily induced by IFN-beta in the parental 2fTGH cell line, but not by recombinant IFN-alpha2, IFN-alpha Con1, or a mixture of IFN-alpha subtypes. IFN-alpha8 induced beta-R1 weakly. beta-R1 was not induced by IFN-beta in mutant cell lines U2A, U3A, U4A, and U6A, which lack, respectively, p48, STAT1, JAK1, and STAT2. U5A cells, which lack the Ifnar 2.2 component of the IFN-alpha and -beta receptor, also failed to express beta-R1. U1A cells are partially responsive to IFN-beta and IFN-alpha8 but lacked beta-R1 expression, indicating that TYK2 protein is essential for induction of this gene. Taken together, these results suggest that the expression of beta-R1 in response to type I IFN requires IFN-stimulated gene factor 3 plus an additional component, which is more efficiently formed on induction by IFN-beta compared with IFN-alpha.
Biliary cancer: Utility of next‐generation sequencing for clinical management (2016)

This is the largest clinically annotated data set of BTC cases with CGP and indicates the potential of CGP for improving outcomes. CGP should be strongly considered in the management of BTC patients. Cancer 2016;122:3838-3847. © 2016 American Cancer Society.
p53 is a suppressor of inflammatory response in mice (2005)

Chronic inflammation is known to promote cancer, suggesting that negative regulation of inflammation is likely to be tumor suppressive. We found that p53 is a general inhibitor of inflammation that acts as an antagonist of nuclear factor kappaB (NFkappaB). We first observed striking similarities in global gene expression profiles in human prostate cancer cells LNCaP transduced with p53 inhibitory genetic element or treated with TNF, suggesting that p53 inhibits transcription of TNF-inducible genes that are largely regulated by NFkappaB. Consistently, ectopically expressed p53 acts as an inhibitor of transcription of NFkappaB-dependent promoters. Furthermore, suppression of inflammatory response by p53 was observed in vivo in mice by comparing wild-type and p53 null animals at molecular (inhibition of transcription of genes encoding cytokines and chemokines, reducing accumulation of reactive oxygen species and protein oxidation products), cellular (activation of macrophages and neutrophil clearance) and organismal (high levels of metabolic markers of inflammation in tissues of p53-deficient mice and their hypersensitivity to LPS) levels. These observations indicate that p53, acting through suppression of NFkappaB, plays the role of a general "buffer" of innate immune response in vivo that is well consistent with its tumor suppressor function and frequent constitutive activation of NFkappaB in tumors.
Saddle-like, π-conjugated, cyclooctatetrathiophene-based, hole-transporting material for perovskite solar cells (2019)

A new HTM incorporating a saddle-like, thiophene-rich core endowed with four triphenylamine units is proposed. The new HTM leads to PSCs reaching efficiencies up to 16.3%.
Sulfasalazine in early rheumatoid arthritis. A 48‐week double‐blind, prospective, placebo‐controlled study (1993)

SSZ is effective in the treatment of RA, and its onset of action is rapid. The results support the view that SSZ retards the development of joint erosions. However, like other conventional disease-modifying antirheumatic drugs, its remission-inducing ability is insufficient.
Expression of HOXA Genes in Patients with Multiple Myeloma (2004)

Multiple Myeloma (MM) is an incurable B-cell malignancy characterized by uncontrolled growth of plasma cells (PCs) in the bone marrow. The pathogenesis of MM is complex and still not fully understood. The HOX genes encode a family of homeodomain containing transcription factors which are crucial for embryonic development and differentiation. The HOX genes are also involved in hematopoiesis and have been shown to be dysregulated in leukemia suggesting a role in leukemogenesis. We hypothesized that expression of the HOX genes might also be of importance in MM. We screened FACS-sorted malignant PCs from a panel of 32 MM patients for the expression of HOXA 2, 3, 4, 7, 9, 10, and 11 genes by RT-PCR assays specific for each gene. We found that 9.4% (3/32) of the MM patients expressed the tested HOX genes in their PCs suggesting that HOXA genes are frequently dysregulated and might have an oncogenic potential in MM.
Human cord blood-derived cells attain neuronal and glial features in vitro (2002)

Neural stem cells are clonogenic, self-renewing cells with the potential to differentiate into brain-specific cell lines. Our study demonstrates that a neural-stem-cell-like subpopulation can be selected and expanded in vitro by the use of human umbilical cord blood cells, which are a relatively easily available starting material. Through a combination of antigen-driven magnetic cell sorting and subfractionation according to cell surface adhesive properties, we have isolated a clonogenic fraction devoid of hematopoietic or angiogenetic properties but with relatively high self-renewal potency. The resulting clones express nestin, a neurofilament protein that is one of the most specific markers of multipotent neural stem cells. In the presence of selected growth factors or in the rat brain co-culture system, the progeny of these cells can be oriented towards the three main neural phenotypes: neurons, astroglia and oligodendroglia. The cells show high commitment (about 30% and 40% of the population) to neuronal and astrocytic fate, respectively. Interestingly, upon differentiation, the neural-type precursor cells of cord blood origin also give rise to a relatively high proportion of oligodendrocytes - 11% of the total population of differentiating cells.
Development of an in vitro model to assess wound-healing response and biocompatibility of intraocular biomaterials (2014)

Macrophages are master regulators of inflammation, fibrosis and wound-healing throughout the body. However, little work to date has examined their role in the inflammatory and fibrotic diseases of the eye. Mounting evidence for macrophage participation in the failure of intraocular implants (called posterior capsule opacification or PCO), and the well-established role of dysfunctional macrophage behaviour during diabetes motivated this investigation. &#13;\nA novel in vitro model of macrophages and lens epithelial cells in co-culture was developed and first used to investigate the macrophage response to common intraocular lens materials, and the possible effect of this response on lens epithelial cells. We observed significant inflammatory macrophage activation and reduced macrophage adhesion by hydrophilic implant surfaces compared to hydrophobic ones. However, the macrophage response to both materials induced the same degree of inflammation in lens epithelial cells. In agreement with previous studies, we conclude that macrophage adhesion and activation are inversely related, and that net inflammatory effect is a function of the degree of macrophage activation and the number of activated cells.&#13;\nThe in vitro model was next used to explore the development of diabetic cataract. During hyperglycemic conditions a significant disruption of macrophage protein expression and delayed macrophage cell-death were observed, which may explain adverse inflammation in diabetes. Lens epithelial cell phenotype remained unchanged, though results from our in vitro model also suggest that lens epithelial cell death as a result of hyperglycemia occurs through a mechanism other than apoptosis, in agreement with the literature. We therefore provide additional evidence to the hypothesis that diabetic cataracts are a product of accumulated oxidative stress during hyperglycemia. Our findings provide a new method of inquiry into macrophage biocompatibility testing of intraocular materials, specifically through quantification of macrophage cell-surface markers and lens epithelial cell cytoskeletal elements.
Building a Web-Features Taxonomy for Structuring Web Design Guidelines (2003)

This paper proposes a framework for structuring web design guidelines that incorporates the hierarchies of web features and their semantic relationships with HTML and CSS. It is argued that this approach will be synchronous with the mental model of web designers, thus making the guidelines more usable. In addition, this approach embraces both external and internal aspects of web design, so there is little compromise on the coverage of web design issues. An experiment was conducted to compare the relative effectiveness of the proposed framework with other guideline structures (e.g., principle-oriented and a mixture of principle and feature-oriented). There was evidence that the principle-oriented guidelines performed worse than the other structures, but the analyses failed to establish that the proposed framework as the most effective. The experiment showed promising results but it suffered from small sample size. In spite of this, it is believed that the proposed taxonomy and framework has laid the groundwork for future research.
Intrathecal Baclofen for Severe Spinal Spasticity (1989)

We studied the effect of the intrathecal infusion of baclofen, an agonist of gamma-aminobutyric acid, on abnormal muscle tone and spasms associated with spinal spasticity, in a randomized double-blind crossover study. Twenty patients with spinal spasticity caused by multiple sclerosis or spinal-cord injury who had had no response to treatment with oral baclofen received an intrathecal infusion of baclofen or saline for three days. The infusions were administered by means of a programmable pump implanted in the lumbar subarachnoid space. Muscle tone decreased in all 20 patients (mean [+/- SD] Ashworth score for rigidity, from 4.0 +/- 1.0 to 1.2 +/- 0.4; P less than 0.0001), and spasms were decreased in 18 of the 19 patients who had spasms (mean [+/- SD] score for spasm frequency, from 3.3 +/- 1.2 to 0.4 +/- 0.8; P less than 0.0005). Tests for motor function, neurologic examination, and assessments by the patients correctly indicated when baclofen was being infused in all cases. All patients were then entered in an open long-term trial of continuous infusion of intrathecal baclofen. During a mean follow-up period of 19.2 months (range, 10 to 33), muscle tone has been maintained within the normal range (mean Ashworth score, 1.0 +/- 0.1) and spasms have been reduced to a level that does not interfere with activities of daily living (mean spasm score, 0.3 +/- 0.6). No drowsiness or confusion occurred, one pump failed, and two catheters became dislodged and had to be replaced. No infections were observed. Our observations suggest that intrathecal baclofen is an effective long-term treatment for spinal spasticity that has not responded to oral baclofen.
Role of virion M2 protein in influenza virus uncoating: specific reduction in the rate of membrane fusion between virus and liposomes by amantadine (1994)

The anti-influenza virus drug amantadine was shown to reduce the rate of fusion of liposomes with influenza A viruses whose replication is inhibited by this drug. The fusion with amantadine-resistant viruses was unaffected. Experiments with reassortant and mutant viruses showed that this effect was linked to the M2 protein and not to the haemagglutinin of the virus. The proton ionophore monensin, on the other hand, substantially increased the rate of fusion of the viruses tested. These results indicate that the kinetics of virus-liposome fusion can be modulated by the virus M2 protein, the target of amantadine action, and it is postulated that the M2 ion channel functions by transporting protons into the virion interior and facilitating virus uncoating.
The Control of Chemotherapy-Induced Emesis (1981)

Nausea and vomiting are frequent and serious toxicities of cancer chemotherapy that have been largely ignored in the past. Recently there has been renewed interest in this significant problem, with important advances in understanding the physiology of vomiting and a burgeoning number of clinical trials that use newer classes of antiemetics. At present phenothiazines are the only class of antiemetics that have shown both efficacy and safety in large numbers of cancer patients, but they are inadequate against strongly emetic agents such as cisplatin. New agents and new approaches have shown promise but need additional testing before they can be recommended for routine use.
4-sensor camera calibration for image representation invariant to shading, shadows, lighting, and specularities (2002)

Most lighting can be accurately modeled using a simplified Planckian function. If we form logarithms of color ratios of camera sensor values, then in a Lambertian plus specular two-lobe model of reflection the temperature-dependent term is separate and is seen as a straight line: i.e., changing lighting amounts to changing each pixel value in a straight line, for a given camera. Here we use a 4-sensor camera. In this case, forming color ratios reduces the dimensionality to 3. Applying logarithms and projecting onto the plane in the 3D color space orthogonal to the light-change direction results in an image representation that is invariant to illumination change. For a given camera, the position of the specular point in the 2D plane is always the same, independent of the lighting. Thus a camera calibration produces illumination invariance at a single pixel. In the plane, matte surfaces reduce to points and specularities are almost straight lines. Extending each pixel value back to the matte position, postulated to be the maximum radius from the fixed specular point, at any angle in the 2D plane, removes specularity. Thus images are independent of shading (by forming ratios), independent of shadows (by making them independent of illumination temperature) and independent of specularities. The method is examined by forming 4D images from hyperspectral images, using real camera sensors, with encouraging results.
A stilbene synthase from Japanese red pine ( Pinus densiflora ): Implications for phytoalexin accumulation and down-regulation of flavonoid biosynthesis (2002)

Stilbene synthase (STS) and chalcone synthase (CHS) are plant-specific polyketide synthases that play key roles in the stilbenoid and flavonoid biosyntheses, respectively. We have recently isolated from Pinus densiflora three STS cDNAs (PDSTS1, PDSTS2, and PDSTS3) and one CHS cDNA (PDCHSX). We then heterologously expressed these cDNAs in Escherichia coli and characterized their properties. An unusual STS isozyme, PDSTS3, lacks the common C-terminal extension of STS because of a frame-shift mutation and shows the highest pinosylvin-forming activity among the STSs tested. Pinosylvin was shown to be a potent inhibitor of PDCHSX (K(i) = 6 microM) as well as PDSTS2 (K(i) = 13 microM), which presumably maintains the balance between the stilbenoid and flavonoid biosyntheses. PDSTS3 was insensitive to product inhibition. We identified PDSTS3 in the pine seedlings as well as full-length STS. The data provide evidence that PDSTS3 is involved in the potential regulation of the stilbenoid and flavonoid biosynthetic pathways in pine trees.
The Electronic Purse: An Overview of Recent Developments and Policy Issues (2021)

Futurists have been speculating about the prospects for a cashless society for many years, and such predictions became more frequent following the introduction of "smart" cards - cards containing a computer chip - in the mid-1970s. One smart-card application of particular interest to central banks is the electronic purse or wallet, which carries a preloaded monetary value and can be used as a means of payment for multiple small-value purchases. This report provides an overview of current major electronic purse projects and other prepaid card applications around the world and examines selected policy issues. It is possible that electronic purses will be used to reduce the cost of small-value transactions. Although implementation of the innovation has been slow because of high start-up costs and uncertainty regarding acceptability of the device to the average consumer, a large number of purse trials are under way around the world. The soundness of both electronic purse products and their issuers could be a matter of interest to central banks and other financial regulatory bodies. Furthermore, national governments may stand to lose a substantial amount of revenue associated with the issuance of coinage and paper currency. The magnitude of such revenue losses would be difficult to estimate, however, both because of limited quantitative understanding of the various current uses of bank notes and because of uncertainty as to the relative attractiveness of electronic purses to consumers and merchants. While it is doubtful that physical currency will fall into disuse in the foreseeable future, growing familiarity with smart-card technology and the substantial reductions in the unit production costs of smart cards in recent years have nevertheless improved the prospects for a feasible electronic replacement for cash. The report concludes that over the next few years, the use of smart-card technology for single-purpose prepaid cards and for debit and credit cards is likely to become more widespread in Canada. Electronic purses may take somewhat longer to come into general use, given that substantial changes will be required both in the payments habits of consumers and in the payments infrastructure of financial institutions and retailers.
Peter Schreiner, Texte zur spätbyzantinischen Finanz- und Wirtschaftsgeschichte in Handschriften der Biblioteca Vaticana. (1995)

Morrisson Cécile. Peter Schreiner, Texte zur spätbyzantinischen Finanz- und Wirtschaftsgeschichte in Handschriften der Biblioteca Vaticana.. In: Revue numismatique, 6e série - Tome 150, année 1995 pp. 292-296.