gebhart/patrepeval huggingface dataset:
Cetuximab, bevacizumab, and irinotecan for patients with primary glioblastoma and progression after radiation therapy and temozolomide: a phase II trial (2010)

The aim of this clinical trial was to investigate safety and efficacy when combining cetuximab with bevacizumab and irinotecan in patients with recurrent primary glioblastoma multiforme (GBM). Patients were included with recurrent primary GBM and progression within 6 months of ending standard treatment (radiotherapy and temozolomide). Bevacizumab and irinotecan were administered IV every 2 weeks. The first 10 patients received bevacizumab 5 mg/kg, but this was increased to 10 mg/kg after interim safety analysis. Irinotecan dose was based on whether patients were taking enzyme-inducing antiepileptic drugs or not: 340 and 125 mg/m(2), respectively. Cetuximab 400 mg/m(2) as loading dose followed by 250 mg/m(2) weekly was administered IV. Forty-three patients were enrolled in the trial, of which 32 were available for response. Radiographic responses were noted in 34%, of which 2 patients had complete responses and 9 patients had partial responses. The 6-month progression-free survival probability was 30% and median overall survival was 29 weeks (95% CI: 23-37 weeks). One patient had lacunar infarction, 1 patient had multiple pulmonary embolisms, and 3 patients had grade 3 skin toxicity, for which 1 patient needed plastic surgery. One patient was excluded due to suspicion of interstitial lung disease. Three patients had deep-vein thrombosis; all continued on study after adequate treatment. Cetuximab in combination with bevacizumab and irinotecan in recurrent GBM is well tolerated except for skin toxicity, with an encouraging response rate. However, the efficacy data do not seem to be superior compared with results with bevacizumab and irinotecan alone.
Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation (2017)

In summary, our findings suggest that residual function of BSEP as well as substrate specificity influence the therapeutic effectiveness of PEBD in progressive familial intrahepatic cholestasis type 2 (PFIC-2).
Intratumoral injection of Clostridium novyi -NT spores induces antitumor responses (2014)

Species of Clostridium bacteria are notable for their ability to lyse tumor cells growing in hypoxic environments. We show that an attenuated strain of Clostridium novyi (C. novyi-NT) induces a microscopically precise, tumor-localized response in a rat orthotopic brain tumor model after intratumoral injection. It is well known, however, that experimental models often do not reliably predict the responses of human patients to therapeutic agents. We therefore used naturally occurring canine tumors as a translational bridge to human trials. Canine tumors are more like those of humans because they occur in animals with heterogeneous genetic backgrounds, are of host origin, and are due to spontaneous rather than engineered mutations. We found that intratumoral injection of C. novyi-NT spores was well tolerated in companion dogs bearing spontaneous solid tumors, with the most common toxicities being the expected symptoms associated with bacterial infections. Objective responses were observed in 6 of 16 dogs (37.5%), with three complete and three partial responses. On the basis of these encouraging results, we treated a human patient who had an advanced leiomyosarcoma with an intratumoral injection of C. novyi-NT spores. This treatment reduced the tumor within and surrounding the bone. Together, these results show that C. novyi-NT can precisely eradicate neoplastic tissues and suggest that further clinical trials of this agent in selected patients are warranted.
Depth of Field Analysis for Multilayer Automultiscopic Displays (2013)

With the re-emergence of stereoscopic displays, through polarized glasses for theatrical presentations and shuttered liquid crystal eyewear in the home, automultiscopic displays have received increased attention. Commercial efforts have predominantly focused on parallax barrier and lenticular architectures applied to LCD panels. Such designs suffer from reduced resolution and brightness. Recently, multilayer LCDs have emerged as an alternative supporting full-resolution imagery with enhanced brightness and depth of field. We present a signal-processing framework for comparing the depth of field for conventional automultiscopic displays and emerging architectures comprising multiple light-attenuating layers. We derive upper bounds for the depths of field, indicating the potential of multilayer configurations to significantly enhance resolution and depth of field, relative to conventional designs.
Electrophysiological study of vocal‐fold mobility disorders using a magnetic stimulator (2002)

In the field of neurolaryngology, there has been a great interest in neurophysiological studies, such as neurography, for the assessment of the integrity of the laryngeal neural pathway. Such tools provide an indication about the site and the nature of the nerve lesion. We have tried to use a magnetically evoked potential to assess the corticolaryngeal pathway in order to provide normative data on laryngeal nerve conductivity and to evaluate the integrity of the laryngeal neural system in patients with vocal-fold mobility disorders. This study was conducted on 26 subjects (10 normal volunteers and 16 patients with vocal-fold immobility) who were primarily selected on the basis of a comprehensive laryngeal evaluation including laryngo-videostroboscopy assessment. Transcranial (cortical) and mastoid (peripheral) magnetic stimulations were performed to evoke muscle action potentials of the thyro-arytenoid (TA) and cricothyroid muscles (CT). In normal volunteers, cortical stimulation leads to contralateral responses (cortical latency) after 10.9 and 11.3 ms and ipsilateral responses after 8.3 and 9.4 ms for right CT and TA muscles, respectively. There was a significant prolongation of cortical latency of the left TA compared with the right TA muscle, whilst no such significant difference was observed in the CT muscles. Peripheral stimulation evoked response (peripheral latency) after 2.8 and 2.7 ms in the right CT and TA, respectively, with the same significant prolongation of the left TA response compared with the right side. Amongst the patient groups, variable patterns of laryngeal muscle response latencies occurred, including normal response latency, lack of response of CT and TA muscles, prolonged peripheral latency with secondary prolonged cortical latency and prolonged cortical latency with normal peripheral latency. The results indicate that the magnetically evoked potential of laryngeal muscles offers an easy, non-invasive technique and could have a role in the assessment of the integrity of corticolaryngeal pathways.
Monoclonal antibodies directed to chemically synthesized lactogangliotetraosylceramide, a leukemia-associated antigen having a novel branching structure. (1987)

Murine leukemia cells (M1), in their undifferentiated state, have been characterized by the presence of cancer-associated lactoganglio-series glycolipids, one of which was identified as lactogangliotetraosylceramide (LcGg4) having a novel branching at the II-Gal of lactosylceramide through GlcNAc beta 1----3 and GalNAc beta 1----4 linkage, as shown below (Kannagi, R., Levery, S.B., and Hakomori, S. (1984) J. Biol. Chem., 259, 8444-8451): GalNAc beta 1----4 Gal beta 1----4Glc beta 1----1Cer GlcNac beta 1----3 Since this glycolipid is a very minor component, it has been difficult to obtain enough of the purified glycolipid for the preparation of a monoclonal antibody. We developed a method to chemically synthesize this glycolipid using a lactose unit, a ceramide unit, and two hexosamine donors as synthons and made the synthetic glycolipid available as an immunogen. The two monoclonal antibodies we obtained (YI328-18 and YI328-51, both IgG3) specifically recognized the novel branching structure and had no cross-reactivity with gangliotriaosylceramide or lactotriaosylceramide. Thus, the antibodies were found to be useful probes to detect lactogangliotetraosylceramide expressed in undifferentiated M1 leukemia cells, which disappears on induced differentiation. The results of this study indicate a new strategy to establish monoclonal antibody directed to novel minor glycolipid markers or their artificially designed analogs, employing chemically synthesized glycolipid antigens.
FUNDAMENTALS OF EEG MEASUREMENT (2002)

Electroencephalographic measurements are commonly used in medical and research areas. This review article presents an introduction into EEG measurement. Its purpose is to help with orientation in EEG field and with building basic knowledge for performing EEG recordings. The article is divided into two parts. In the first part, background of the subject, a brief historical overview, and some EEG related research areas are given. The second part explains EEG recording.
Transformation Systems of non- Saccharomyces Yeasts (2001)

This review describes the transformation systems including vectors, replicons, genetic markers, transformation methods, vector stability, and copy numbers of 13 genera and 31 species of non-Saccharomyces yeasts. Schizosaccharomyces pombe was the first non-Saccharomyces yeast studied for transformation and genetics. The replicons of non-Saccharomyces yeast vectors are from native plasmids, chromosomal DNA, and mitochondrial DNA of Saccharomyces cerevisiae, non-Saccharomyces yeasts, protozoan, plant, and animal. Vectors such as YAC, YCp, YEp, YIp, and YRp were developed for non-Saccharomyces yeasts. Forty-two types of genes from bacteria, yeasts, fungi, and plant were used as genetic markers that could be classified into biosynthetic, dominant, and colored groups to construct non-Saccharomyces yeasts vectors. The LEU2 gene and G418 resistance gene are the two most popular markers used in the yeast transformation. All known transformation methods such as spheroplast-mediating method, alkaline ion treatment method, electroporation, trans-kingdom conjugation, and biolistics have been developed successfully for non-Saccharomyces yeasts, among which the first three are most widely used. The highest copy number detected from non-Saccharomyces yeasts is 60 copies in Kluyveromyces lactis. No general rule is known to illustrate the transformation efficiency, vector stability, and copy number, although factors such as vector composition, host strain, transformation method, and selective pressure might influence them.
Randomized, controlled trial of recombinant human interleukin‐11 in patients with active Crohn's disease (2002)

Weekly subcutaneous injection with rhIL-11 15 microg/kg is safe and effective in inducing remission in a subset of patients with active Crohn's disease.
The enigma of multiple sclerosis: inflammation and neurodegeneration cause heterogeneous dysfunction and damage (2003)

Oligodendrocyte precursors are abundant in multiple sclerosis lesions, but fail to remyelinate. Oligodendrocyte growth and regeneration are probably compromised by the action of growth inhibitory signals and lack of growth stimuli. Inflammatory cells and mediators induce axonal loss as well as demyelination. The degenerative response is therefore an integral and early component of multiple sclerosis.
Whole‐heart coronary MRA with 100% respiratory gating efficiency: Self‐navigated three‐dimensional retrospective image‐based motion correction (TRIM) (2013)

We have developed a new respiratory motion correction technique for coronary MRA that enables 1 mm(3) isotropic resolution and whole-heart coverage with 7 min of scan time. Further tests on patient population are needed to determine its clinical usage.
Characterization of the affinities of insulin-like growth factor (IGF)-binding proteins 1-4 for IGF-I, IGF-II, IGF-I/insulin hybrid, and IGF-I analogs. (1993)

Insulin-like growth factor (IGF)-binding proteins (BPs) bind IGF-I and IGF-II with high affinity and modify the activity of IGF peptides in a complex manner. We have characterized the affinities of IGFBP-1-4 for IGF-I and -II by employing 1) purified IGFBP preparations, 2) both [125I]IGF-I and [125I]IGF-II as radioligands, and 3) multiple IGF analogs designed to have altered affinities for IGFBPs. To this end, human (h) IGFBP-1, hIGFBP-2, and rat (r) IGFBP-4 have been purified to homogeneity from human amniotic fluid, human prostate epithelial cell culture, and B104 rat neuroblastoma cells; for human IGFBP-3, the glycosylated recombinant form (rec-hIGFBP-3), produced in Chinese hamster ovary cells, was employed. The IC50 values of IGF-I for hIGFBP-1, hIGFBP-2, rec-hIGFBP-3, rIGFBP-4, and human serum IGFBPs were 0.05 +/- 0.01, 5.0 +/- 0.01, 0.25 +/- 0.20, 0.6 +/- 0.4, and 0.1 +/- 0.01 ng/ml, respectively. While hIGFBP-1 and rIGFBP-4 had virtually equivalent affinities for IGF-I and IGF-II, hIGFBP-2 and rec-hIGFBP-3 demonstrated 2- to 5-fold higher affinities for IGF-II than for IGF-I. Studies with [Gln3,Ala4,Tyr15,Leu16]IGF-I and Des-(1-3)-IGF-I indicate that specific residues in the first 16 amino acids of the B domain of IGF-I appear to be critical for binding to all of the IGFBPs tested, but not to IGF receptors. However, severe modifications in the B domain disrupt binding affinity, not only for IGFBPs, but also for receptors (IGF-I/insulin hybrid and B-chain mutant). Interestingly, modifications in the A domain of IGF-I, which is believed to contain residues critical for binding to IGF-I and insulin receptors, show differential effects on binding affinity to BPs. [Thr49,Ser50,Ile51]IGF-I, which has normal affinity for the type I IGF receptor, shows at least a 500-fold decreased affinity for hIGFBP-1 and recombinant hIGFBP-3, in contrast to 50- to 100-fold reduced affinity for hIGFBP-2 and rIGFBP-4, and 5- to 10-fold reduced affinity for purified human serum IGFBP-3. More significantly, [1-27,Gly4,38-70]IGF-I shows a 30-fold decreased affinity for the type I IGF receptor and 10- and 2.5-fold reduced affinities for hIGFBP-1 and rec-hIGFBP-3, respectively, but no reduction in affinity for hIGFBP-2 or rIGFBP-4.(ABSTRACT TRUNCATED AT 400 WORDS)
Organic Richness and Productivity Index Relationship in Dual Porosity Flow-System of Gas and Condensate Kerogen Reservoirs of Najmah Formation, North Kuwait (2009)

Abstract The Najmah formation of Jurassic age has been tested and found to be a prolific source-rock as well as a producer of gas, condensate and light oil in different wells discovered from various fields of North Kuwait. The challenges of this unconventional reservoir are its dual porosity nature and its relation to the flow controlling system in view of very low porosity and the dependency on natural fracture network system as flowing mechanism. The drill stem test (DST) results at some wells were quite successful without any stimulation, while at other wells the DSTs were unsuccessful in spite of advanced and repeated stimulations, thus categorizing the Najmah as a geologically-complex, naturally-fractured tight gas and condensate reservoir. Pressure transient analysis and flow regime interpretation of the successfully run Drill Stem Tested (DST) wells confirm the dual porosity flow-system and the fractured nature of the reservoir. In this paper, the authors will point out the relationship between organic richness (Total Organic Content, TOC) of lower Najmah sub-unit and Productivity Index (PI). The term "matrix-dominated" is used to represent units with some dual-pore systems showing a typical profile with initial fracture flow and stabilized matrix support. The term "fracture-dominated" is used for units flowing through a fracture network but with limited matrix support. The cross-plot shows that PI increases with higher values of TOC, up to 2.45% which is the upper limit of TOC window, within which Najmah has been successfully tested as dual pore-system, matrix-dominated Kerogen reservoir, while fracture-dominated dual pore-flow system lie as outliers. The authors strongly feel that this finding will tremendously change the current understanding of the prospectivity and predictive estimation of productivity of the Najmah formation in other fields in Kuwait as well as in other regions.
Diode-triggered SCR (DTSCR) for RF-ESD protection of BiCMOS SiGe HBTs and CMOS ultra-thin gate oxides (2004)

A novel diode-triggered SCR (DTSCR) ESD protection element is introduced for low-voltage application (signal, supply voltage /spl les/1.8 V) and extremely narrow ESD design margins. Trigger voltage engineering in conjunction with fast and efficient SCR voltage clamping is applied for the protection of ultra-sensitive circuit nodes, such as SiGe HBT bases (e.g. f/sub Tmax/=45 GHz in BiCMOS-0.35 /spl mu/m LNA input) and thin gate-oxides (e.g. tox=1.7 nm in CMOS-0.09 /spl mu/m input). SCR integration is possible based on CMOS devices or can alternatively be formed by high-speed SiGe HBTs.
Lymphatic Neoangiogenesis in Human Kidney Transplants Is Associated with Immunologically Active Lymphocytic Infiltrates (2004)

Renal transplant rejection is caused by a lymphocyte-rich inflammatory infiltrate that attacks cortical tubules and endothelial cells. Immunosuppressive therapy reduces the number of infiltrating cells; however, their exit routes are not known. Here a >50-fold increase of lymphatic vessel density over normal kidneys in grafts with nodular mononuclear infiltrates is demonstrated by immunohistochemistry on human renal transplant biopsies using antibodies to the lymphatic endothelial marker protein podoplanin. Nodular infiltrates are constantly associated with newly formed, Ki-67-expressing lymphatic vessels and contain the entire repertoire of T and B lymphocytes to provide specific cellular and humoral alloantigenic immune responses, including Ki-67(+) CD4(+) and CD8(+) T lymphocytes, S100(+) dendritic cells, and Ki-67(+)CD20(+) B lymphocytes and lambda- and kappa-chain-expressing plasmacytoid cells. Numerous chemokine receptor CCR7(+) cells within the nodular infiltrates seemed to be attracted by secondary lymphatic chemokine (SLC/CCL21) that is produced and released by lymphatic endothelial cells in a complex with podoplanin. From these results, it is speculated that lymphatic neoangiogenesis not only contributes to the export of the rejection infiltrate but also is involved in the maintenance of a potentially detrimental alloreactive immune response in renal transplants and provides a novel therapeutic target.
Elevated plasma levels of IgE in Plasmodium falciparum-primed individuals reflect an increased ratio of IL-4 to interferon-gamma (IFN-γ)-producing cells (1997)

People living in Plasmodium falciparum-endemic areas frequently have elevated levels of total as well as P. falciparum-specific serum IgE. This study aimed at investigating whether the elevated serum IgE levels reflect a shift in the balance between CD4+ T helper 1 (Th1) and T helper 2 (Th2) cells in individuals naturally exposed to the P. falciparum parasite. To investigate the role of Th1 and Th2 cells in the human P. falciparum system we used the ELISPOT assay to determine the ratio of IFN-gamma- and IL-4-producing cells after specific antigen or mitogen activation in vitro. The donors were individuals who had acquired immunity through natural exposure to the parasite. In response to the specific malaria antigens, very few IL-4-producing cells were seen. However, in the response of individual donors to the polyclonal T cell activator, leucoagglutinin (La), the anti-malarial IgE levels in plasma were correlated with an increased ratio of IL-4/IFN-gamma producing cells. Thus, donors with ratios of IL-4/IFN-gamma > 1 exhibited mean plasma anti-malarial IgE levels significantly greater than those with ratios < 1. In individuals not living in P. falciparum-endemic areas the ratio of IL-4/IFN-gamma was always < 1. Taken together, our data suggest a shift in the balance between Th1 and Th2 cells in naturally P. falciparum-primed individuals, associated with elevated anti-P. falciparum plasma IgE levels. The role and biological significance of IgE (Th2-type immune response) for protection against P. falciparum and/or pathogenesis of malaria require further study.
Substituent effects in the electroreduction of porphyrins and metalloporphyrins (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstituent effects in the electroreduction of porphyrins and metalloporphyrinsA. Giraudeau, H. J. Callot, Joseph Jordan, I. Ezhar, and Maurice GrossCite this: J. Am. Chem. Soc. 1979, 101, 14, 3857–3862Publication Date (Print):July 1, 1979Publication History Published online1 May 2002Published inissue 1 July 1979https://pubs.acs.org/doi/10.1021/ja00508a024https://doi.org/10.1021/ja00508a024research-articleACS PublicationsRequest reuse permissionsArticle Views1584Altmetric-Citations190LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Weighted rational transductions and their application to human language processing (1994)

We present the concepts of weighted language, transduction and automaton from algebraic automata theory as a general framework for describing and implementing decoding cascades in speech and language processing. This generality allows us to represent uniformly such information sources as pronunciation dictionaries, language models and lattices, and to use uniform algorithms for building decoding stages and for optimizing and combining them. In particular, a single automata join algorithm can be used either to combine information sources such as a pronunciation dictionary and a context-dependency model during the construction of a decoder, or dynamically during the operation of the decoder. Applications to speech recognition and to Chinese text segmentation will be discussed.