gebhart/patrepeval huggingface dataset:
Comparing images using color coherence vectors (1996)

Article Free Access Share on Comparing images using color coherence vectors Authors: Greg Pass Computer Science Department, Cornell University, Ithaca, NY Computer Science Department, Cornell University, Ithaca, NYView Profile , Ramin Zabih Computer Science Department, Cornell University, Ithaca, NY Computer Science Department, Cornell University, Ithaca, NYView Profile , Justin Miller Computer Science Department, Cornell University, Ithaca, NY Computer Science Department, Cornell University, Ithaca, NYView Profile Authors Info & Claims MULTIMEDIA '96: Proceedings of the fourth ACM international conference on MultimediaFebruary 1997 Pages 65–73https://doi.org/10.1145/244130.244148Published:01 February 1997Publication History 444citation2,791DownloadsMetricsTotal Citations444Total Downloads2,791Last 12 Months324Last 6 weeks35 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Epidemiology, transmission dynamics and control of SARS: the 2002–2003 epidemic (2004)

This paper reviews current understanding of the epidemiology, transmission dynamics and control of the aetiological agent of severe acute respiratory syndrome (SARS). We present analyses of data on key parameters and distributions and discuss the processes of data capture, analysis and public health policy formulation during the SARS epidemic are discussed. The low transmissibility of the virus, combined with the onset of peak infectiousness following the onset of clinical symptoms of disease, transpired to make simple public health measures, such as isolating patients and quarantining their contacts, very effective in the control of the SARS epidemic. We conclude that we were lucky this time round, but may not be so with the next epidemic outbreak of a novel aetiological agent. We present analyses that help to further understanding of what intervention measures are likely to work best with infectious agents of defined biological and epidemiological properties. These lessons learnt from the SARS experience are presented in an epidemiological and public health context.
Endocytosis of Oxidized Low Density Lipoprotein through Scavenger Receptor CD36 Utilizes a Lipid Raft Pathway That Does Not Require Caveolin-1 (2003)

The scavenger receptor CD36 binds a diverse array of ligands, including thrombospondin-1, oxidized low density lipoprotein (OxLDL), fatty acids, anionic phospholipids, and apoptotic cells. CD36 has been reported to be present in lipid rafts/caveolae, but little is known about the membrane trafficking of this protein at baseline or following ligand binding. Here, we determined that expression of CD36 in Chinese hamster ovary (CHO) cells and endogenous expression of CD36 in C32 cells led to a homogeneous distribution of the protein on the plasma membrane, as judged by confocal fluorescence microscopy. This homogeneous pattern was observed both by anti-CD36 antibody staining and by live cell imaging of CHO cells expressing a chimeric CD36-green fluorescent protein construct. In contrast, caveolin-1 displayed its usual punctate surface distribution. Correspondingly, dual labeling of CD36 and caveolin-1 showed essentially no overlap, neither by immunofluorescence light microscopy nor by immunogold electron microscopy. Furthermore, isolation of lipid rafts by sucrose gradient ultracentrifugation of cold Triton X-100 cell lysates yielded both CD36 and caveolin-1, but immunoprecipitates of caveolin-1 did not contain CD36. Binding of Ox-LDL led to internalization of CD36 and OxLDL into endosomal structures that did not contain caveolin-1 or transferrin but that co-internalized the glycosyl-phosphatidylinositol-anchored protein decay accelerating factor, a lipid raft protein. Furthermore, expression of CD36 in the caveolin-1-negative KB cell line is sufficient for OxLDL-induced internalization of CD36, indicating that caveolin-1 is not required for this endocytic process. Taken together, these data demonstrate that at steady state, CD36 is localized in lipid rafts but not in caveolae, and that binding of OxLDL to CD36 leads to endocytosis through a lipid raft pathway that is distinct from the clathrin-mediated or caveolin internalization pathways.
Oral delivery of bioencapsulated exendin‐4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta‐TC6 cells (2012)

Glucagon-like peptide (GLP-1) increases insulin secretion but is rapidly degraded (half-life: 2 min in circulation). GLP-1 analogue, exenatide (Byetta) has a longer half-life (3.3-4 h) with potent insulinotropic effects but requires cold storage, daily abdominal injections with short shelf life. Because patients with diabetes take >60 000 injections in their life time, alternative delivery methods are highly desired. Exenatide is ideal for oral delivery because insulinotropism is glucose dependent, with reduced risk of hypoglycaemia even at higher doses. Therefore, exendin-4 (EX4) was expressed as a cholera toxin B subunit (CTB)-fusion protein in tobacco chloroplasts to facilitate bioencapsulation within plant cells and transmucosal delivery in the gut via GM1 receptors present in the intestinal epithelium. The transgene integration was confirmed by PCR and Southern blot analysis. Expression level of CTB-EX4 reached up to 14.3% of total leaf protein (TLP). Lyophilization of leaf material increased therapeutic protein concentration by 12- to 24-fold, extended their shelf life up to 15 months when stored at room temperature and eliminated microbes present in fresh leaves. The pentameric structure, disulphide bonds and functionality of CTB-EX4 were well preserved in lyophilized materials. Chloroplast-derived CTB-EX4 showed increased insulin secretion similar to the commercial EX4 in beta-TC6, a mouse pancreatic cell line. Even when 5000-fold excess dose of CTB-EX4 was orally delivered, it stimulated insulin secretion similar to the intraperitoneal injection of commercial EX4 but did not cause hypoglycaemia in mice. Oral delivery of the bioencapsulated EX4 should eliminate injections, increase patient compliance/convenience and significantly lower their cost.
<title>Head tracking relative to a moving vehicle or simulator platform using differential inertial sensors</title> (2000)

Inertial trackers have been successfully applied to a wide range of HMD applications including virtual environment training, VR gaining and even fixed-base vehicle simulation, in which they have gained widespread acceptance due to their superior resolution and low latency. Until now, it has been impossible to use inertial trackers in applications which require tracking motion relative to a moving platform, such as motion-base simulators, virtual environment trainers deployed on board ships, and live vehicular applications including helmet-mounted cueing systems and enhanced vision or situational awareness displays. This paper describes a new technique which makes it possible to use inertial head- tracking systems on-board moving platforms by computing the motion of a `tracking' Inertial Measurement Unit (IMU) mounted on the HMD relative to a `reference' IMU rigidly attached to the moving platform. Detailed kinematic equations are derived, and simulation results are provided for the particular case of an inertial tracker with drift correction by means of ultrasonic ranging sensors, but the conclusions can be applied to hybrid inertial trackers involving optical, magnetic, or RF drift correction as well.
Handbook of Epoxy Resins (1967)

Synthese de resines epoxydes type glycidyl; synthese a partir d'olefines et chloroacetyls; Caracterisation de resines epoxydes non vulcanisees; Mecanisme de vulcanisation. Caracterisation d'agents de vulcanisation (amines aliphatiques primaires, aromatiques primaires, secondaires et tertiaires, amides et composes nitrogenes, acides anhydride-acide); Diluants pour resine epoxyde. Modificateurs resinaux; Assouplissants et plastifiants pour resines epoxydes, coulage et encapsulation par les resines epoxydes. Les resines epoxydes dans l'outillage; Mousse, composes de moulage et de revetement, adhesifs, composites; Methodes de manipulation et precautions de securite.
A Highly Selective Cc Chemokine Receptor (Ccr)8 Antagonist Encoded by the Poxvirus Molluscum Contagiosum (2000)

The MC148 CC chemokine from the human poxvirus molluscum contagiosum (MCV) was probed in parallel with viral macrophage inflammatory protein (vMIP)-II encoded by human herpesvirus 8 (HHV8) in 16 classified human chemokine receptors. In competition binding using radiolabeled endogenous chemokines as well as radiolabeled MC148, MC148 bound with high affinity only to CCR8. In calcium mobilization assays, MC148 had no effect on its own on any of the chemokine receptors, but in a dose-dependent manner blocked the stimulatory effect of the endogenous I-309 chemokine on CCR8 without affecting chemokine-induced signaling of any other receptor. In contrast, vMIP-II acted as an antagonist on 10 of the 16 chemokine receptors, covering all four classes: XCR, CCR, CXCR, and CX(3)CR. In chemotaxis assays, MC148 specifically blocked the I-309-induced response but, for example, not stromal cell-derived factor 1alpha, monocyte chemoattractant protein 1, or interleukin 8-induced chemotaxis. We thus concluded that the two viruses choose two different ways to block the chemokine system: HHV8 encodes the broad-spectrum chemokine antagonist vMIP-II, whereas MCV encodes a highly selective CCR8 antagonist, MC148, conceivably to interfere with monocyte invasion and dendritic cell function. Because of its pharmacological selectivity, the MC148 protein could be a useful tool in the delineation of the role played by CCR8 and its endogenous ligand, I-309.
A MEMS sensor array for explosive particle detection (2005)

In this work, a micro-electro-mechanical system (MEMS) sensor array which is capable of detecting explosive particles has been designed and fabricated. The array consists of 12 silicon beams, on each beam there are a heater and a temperature sensor. AH silicon beams can be heated up to melting point of particular kind of explosive by the heaters, while each sensor is used to measure the temperature change of each beam caused by heat absorption of the explosive particles when they melt Experimental results show that the array is capable of detecting trinitrotoluene (TNT) and cyclotrimethylenetrinitramine (RDX) samples as little as 1/spl mu/g.
New synthesis of 3-alkyl-2-cyclopenten-2-ol-1-ones (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew synthesis of 3-alkyl-2-cyclopenten-2-ol-1-onesCharles M. LeirCite this: J. Org. Chem. 1970, 35, 10, 3203–3205Publication Date (Print):October 1, 1970Publication History Published online1 May 2002Published inissue 1 October 1970https://doi.org/10.1021/jo00835a001RIGHTS & PERMISSIONSArticle Views170Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (395 KB) Get e-Alertsclose Get e-Alerts
Evaluation of 45S5 Bioactive Glass Combined as a Bone Substitute in the Reconstruction of Critical Size Calvarial Defects in Rabbits (2005)

Biomaterial research and tissue engineering have guided new developments in bone replacement. In this study, the osteoconductive and osteoinductive properties of 45S5 Bioglass (Novabone-C/M, Porex Surg., Newnan, GA), granules as a bone replacement material for large calvarial defects were evaluated. Rabbit periosteal cells were expanded in culture and used in vivo. Alkaline-phosphatase assay, collagen type I, and calcium expression were applied to confirm osteoblast phenotype. In the in vivo phase, a 15-mm diameter critical size calvarial defect was created in rabbits (n = 14). The defect was reconstructed according to four treatment groups: autogenous bone (n = 2), Bioglass alone (n = 2), Bioglass + bone (n = 5), Bioglass + periosteal cells (n = 5). The animals were killed 12 weeks after surgery, and the samples were analyzed. Periosteal cells grew successfully in vitro. Because of their fast proliferation and potential to differentiate into osteoblasts, they were an excellent source of cells for bone tissue engineering. The best ossification was seen when autogenous bone was used (79.4% ossified), whereas only 8.2% of the defect in the Bioglass group showed ossification. Addition of bone or cells to the Bioglass increased the area of ossification to 42.7% and 30.2%, respectively. Defects replaced with Bioglass showed varying degrees of inflammatory reaction because of the intense cell-mediated biodegradation process. Based on these findings, the use of Bioglass granules to repair large craniofacial defects cannot be advised.
Irritation Induced Bladder Overactivity is Suppressed by Tibial Nerve Stimulation in Cats (2011)

Activation of somatic afferents in the tibial nerve of cats can partially reverse the bladder overactivity induced by intravesical administration of a chemical irritant that activates C-fiber afferent nerves. These data are consistent with clinical studies showing that tibial nerve neuromodulation is effective treatment for overactive bladder symptoms.
An integrated system for navigation and positioning of an ROV for scientific exploration (2002)

The NOAA Vents program and Canada's Pacific Geoscience Centre and Institute of Ocean Sciences have recently collaborated in an effort to utilize Canada's HYSUB 5000 ROV in the study of hydrothermal venting and seafloor processes along a mid-ocean ridge. A navigation system has been developed to geodetically position the ROV over rough terrain in deep water using a long baseline acoustic net, differential GPS and software tailored to the needs of the operators and scientists. Ship positioning and station-keeping is a vital part of successful ROV operations and special considerations were given for operation from a non-dynamically positioned research vessel. With the growing acceptance of remotely operated vehicles for performing tasks previously allocated to manned submersibles, the demands on the navigation system have increased. To date, the navigation system has produced good geodetic results while the ROV has successfully sampled hot water vents, connected to a deeply moored instrument package for data retreival, collected biological samples and photographed large areas of the seafloor-all tasks previously performed by ALVIN in the VENTS and RIDGE research programs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Immunological issues in vaccine trials: T-cell responses. (1998)

T-cell responses are both extremely diverse and dependent on the MHC of the immunized (or infected) individual. Apart from T-cell proliferation assays, the most informative functional T-cell assays are still difficult to perform. Antibody measurements provide a very indirect assessment of the helper arm of the T-cell response. On the other hand, measuring cytolytic T cells (CTL) remains a difficult task, which has precluded the evaluation of CTL responses in vaccine efficacy trials. Accordingly, even though there are reasons to suspect that CTL are important to clear certain infections and to vaccinate against certain diseases, particularly chronic viral infections such as that caused infection by HIV, the data to support these claims are largely missing in humans. Improving and automating CTL assays would have a significant impact on vaccine design. The Immunoscope technology is a PCR based approach which describes the T cell repertoire by several thousands of measurements. This allows the detection of clonal expansions and to evaluate the oligoclonality of pathological T cell infiltrates in humans. In the mouse, it has allowed us to establish the concept of public T-cell responses which are recurrent in individual animals sharing the same MHC. This concept can occasionally apply to humans since we found a public T-cell expansion in DR2a patients at the onset of multiple sclerosis. Single chain class I MHC molecules have been produced, purified, homogeneously loaded with an antigenic peptide, and coated on to beads. This formulation appears to be efficient for induction of primary CTL in vitro . A similar approach can be used to purify peptide specific T cells, and its coupling with the Immunoscope technology is being considered. The potential of these new approaches for T-cell analyses will be discussed.
Folding in vivo of a newly translated yeast cytosolic enzyme is mediated by the SSA class of cytosolic yeast Hsp70 proteins (1998)

The nature of chaperone action in the eukaryotic cytosol that assists newly translated cytosolic proteins to reach the native state has remained poorly defined. Actin, tubulin, and Galpha transducin are assisted by the cytosolic chaperonin, CCT, but many other proteins, for example, ornithine transcarbamoylase (OTC), a cytosolic homotrimeric enzyme of yeast, do not require CCT action. Here, we observe that yeast cytosolic OTC is assisted to its native state by the SSA class of yeast cytosolic Hsp70 proteins. In vitro, refolding of OTC diluted from denaturant was assisted by crude yeast cytosol and ATP and found to be directed by SSA1/2. In vivo, when OTC was induced in a temperature-sensitive SSA-deficient strain, it exhibited reduced specific activity, and nonnative subunits were detected in the soluble fraction. These findings indicate that, in vivo, the Hsp70 system assists in folding at least some newly translated cytosolic enzymes, most likely functioning in a posttranslational manner.
Antiinflammatory 3,4-dihydro-2-alkyl-3-oxo-2H-1,2-benzothiazine-4-carboxamide 1,1-dioxides (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntiinflammatory 3,4-dihydro-2-alkyl-3-oxo-2H-1,2-benzothiazine-4-carboxamide 1,1-dioxidesJoseph G. Lombardino and Edward H. WisemanCite this: J. Med. Chem. 1971, 14, 10, 973–977Publication Date (Print):October 1, 1971Publication History Published online1 May 2002Published inissue 1 October 1971https://pubs.acs.org/doi/10.1021/jm00292a022https://doi.org/10.1021/jm00292a022research-articleACS PublicationsRequest reuse permissionsArticle Views209Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Flexible Sand Barrier (FSB): A Novel Sand Control System (1989)

ABSTRACT A series of experiments were conducted to determine the utility of a Flexible Sand Barrier (FSB) (helically wound flexible metal tubing) as a permeable casing within horizontal boreholes. These experiments focused on its production capacity and filtering capability. A test cell was developed which allowed testing over a range of pressure drops with or without a gravel pack. Laboratory in flow tests indicated 0.10 to 0.21 m3/d per meter (0.2 to 0.4 bbl/d per foot) of FSB in a 30 psi (0.21 MPa) reservoir with 1.0 Pa s (1000 cp) oil. Several configurations of the product from various manufacturers were compared and a suitable candidate was chosen for field testing which is underway.
Steroids. LXXIII.1a The Direct Oppenauer Oxidation of Steroidal Formate Esters. A New Synthesis of 17α-Hydroxyprogesterone1b (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteroids. LXXIII.1a The Direct Oppenauer Oxidation of Steroidal Formate Esters. A New Synthesis of 17α-Hydroxyprogesterone1bH. J. Ringold, Bjarte Löken, G. Rosenkranz, and Franz SondheimerCite this: J. Am. Chem. Soc. 1956, 78, 4, 816–819Publication Date (Print):February 1, 1956Publication History Published online1 May 2002Published inissue 1 February 1956https://doi.org/10.1021/ja01585a030RIGHTS & PERMISSIONSArticle Views533Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (516 KB) Get e-Alerts Get e-Alerts
Bromodomain inhibitors reduce proliferation and increase apoptosis of human neuroendocrine tumour cells (2014)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Application of Nano-lignocellulose for Removal of Nickel Ions from Aqueous Solutions (2016)

Nickel is one of the toxin heavy metals in surface waters. Developing new approaches aimed at removing heavy metals from aqueous solutions that are simultaneously economical and environmentally friendly is of great importance. The purpose of this study will be using Nano-lignocellulose adsorbent as a natural material to remove nickel heavy metal. In this study, several important environmental parameters were studied such as: pH, adsorbent concentration, duration of exposure, concentration and temperature on the uptake, as well as adsorption and Kinetic isotherms. The maximum adsorption efficiency (99.5%) occurred at pH=6. Optimum contact time was measured 30 minutes, which reflects the short duration of the analysis. Results of researches in the field of adsorption isotherm shown that, the best fit of the experimental data corresponds to the Langmuir isotherm model. Kinetic studies revealed that the process of elimination well matches with pseudo-second-order kinetic model. So, the Nano-lignocellulose has high ability to remove nickel from aqueous solutions and as a new adsorbent could be used in different industrial effluents.