gebhart/patrepeval huggingface dataset:
Fast and Stable Color Balancing for Images and Augmented Reality (2012)

This paper addresses the problem of globally balancing colors between images. The input to our algorithm is a sparse set of desired color correspondences between a source and a target image. The global color space transformation problem is then solved by computing a smooth vector field in CIE Lab color space that maps the gamut of the source to that of the target. We employ normalized radial basis functions for which we compute optimized shape parameters based on the input images, allowing for more faithful and flexible color matching compared to existing RBF-, regression- or histogram-based techniques. Furthermore, we show how the basic per-image matching can be efficiently and robustly extended to the temporal domain using RANSAC-based correspondence classification. Besides interactive color balancing for images, these properties render our method extremely useful for automatic, consistent embedding of synthetic graphics in video, as required by applications such as augmented reality.
Supramolecular assemblies, a crystal structure, and a polymer of N-diacetylenic gluconamides (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSupramolecular assemblies, a crystal structure, and a polymer of N-diacetylenic gluconamidesJuergen Hinrich Fuhrhop, Peter Blumtritt, Christian Lehmann, and Peter LugerCite this: J. Am. Chem. Soc. 1991, 113, 19, 7437–7439Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/ja00019a060https://doi.org/10.1021/ja00019a060research-articleACS PublicationsRequest reuse permissionsArticle Views337Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
An Introduction to Contingent (Closed-Loop) Brain Electrical Stimulation for Seizure Blockage, to Ultra-short-term Clinical Trials, and to Multidimensional Statistical Analysis of Therapeutic Efficacy (2001)

Automated seizure blockage is a top research priority of the American Epilepsy Society. This delivery modality (referred to herein as contingent or closed loop) requires for implementation a seizure detection algorithm for control of delivery of therapy via a suitable device. The authors address the many potential advantages of this modality over conventional alternatives (periodic or continuous), and the challenges it poses in the design and analysis of trials to assess efficacy and safety-in the particular context of direct delivery of electrical stimulation to brain tissue. The experimental designs of closed-loop therapies are currently limited by ethical, technical, medical, and practical considerations. One type of design that has been used successfully in an in-hospital "closed-loop" trial using subjects undergoing epilepsy surgery evaluation as their own controls is discussed in detail. This design performs a two-way comparison of seizure intensity, duration, and extent of spread between the control (surgery evaluation) versus the experimental phase, and, within the experimental phase, between treated versus untreated seizures. The proposed statistical analysis is based on a linear model that accounts for possible circadian effects, changes in treatment protocols, and other important factors such as change in seizure probability. The analysis is illustrated using seizure intensity as one of several possible end points from one of the subjects who participated in this trial. In-hospital ultra-short-term trials to assess safety and efficacy of closed-loop delivery of electrical stimulation for seizure blockage are both feasible and valuable.
Development and evaluation of a safe and effective sugar‐free herbal lollipop that kills cavity‐causing bacteria (2011)

Dental caries (tooth decay) is caused by a specific group of cariogenic bacteria, like Streptococcus mutans, which convert dietary sugars into acids that dissolve the mineral in tooth structure. Killing cariogenic bacteria is an effective way to control or prevent tooth decay. In a previous study, we discovered a novel compound (Glycyrrhizol A), from the extraction of licorice roots, with strong antimicrobial activity against cariogenic bacteria. In the current study, we developed a method to produce these specific herbal extracts in large quantities, and then used these extracts to develop a sugar-free lollipop that effectively kills cariogenic bacteria like Streptococcus mutans. Further studies showed that these sugar-free lollipops are safe and their antimicrobial activity is stable. Two pilot human studies indicate that a brief application of these lollipops (twice a day for ten days) led to a marked reduction of cariogenic bacteria in oral cavity among most human subjects tested. This herbal lollipop could be a novel tool to promote oral health through functional foods.
Internal coordination at tin promotes selective alkyl transfer in the Stille coupling reaction (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInternal coordination at tin promotes selective alkyl transfer in the Stille coupling reactionEdwin Vedejs, Anthony R. Haight, and William O. MossCite this: J. Am. Chem. Soc. 1992, 114, 16, 6556–6558Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/ja00042a044https://doi.org/10.1021/ja00042a044research-articleACS PublicationsRequest reuse permissionsArticle Views1839Altmetric-Citations139LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Indoor geolocation science and technology (2002)

This article presents an overview of the technical aspects of the existing technologies for wireless indoor location systems. The two major challenges for accurate location finding in indoor areas are the complexity of radio propagation and the ad hoc nature of the deployed infrastructure in these areas. Because of these difficulties a variety of signaling techniques, overall system architectures, and location finding algorithms are emerging for this application. This article provides a fundamental understanding of the issues related to indoor geolocation science that are needed for design and performance evaluation of emerging indoor geolocation systems.
Fiber optic broadband ultrasonic probe (2008)

An ultrasonic probe was developed by using, in conjunction, opto-acoustic and acousto-optic devices based on fiber optic technology. The intrinsic high frequency and wide bandwidth associated both to the opto-acoustic source and to the interferometric acousto-optic element could open a way towards a ldquovirtual biopsyrdquo of the biological tissue by means of appropriate signal processing techniques to investigate frequency-selective responses in tissue. Extreme miniaturization, which can be obtained by fiber optic technology, permits the positioning of the probe in the close proximity of the focal lesion, avoiding the reduction of the penetration depth imposed by the strong attenuation at high frequency.
Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation (2007)

Platelets play an important role in hemostasis, with inappropriate platelet activation being a major contributor to debilitating and often fatal thrombosis by causing myocardial infarction and stroke. Although current antithrombotic treatment is generally well tolerated and effective, many patients still experience cardiovascular problems, which may reflect the existence of alternative underlying regulatory mechanisms in platelets to those targeted by existing drugs. In this study, we define a role for peripherally distributed members of the tachykinin family of peptides, namely substance P and the newly discovered endokinins A and B that are present in platelets, in the activation of platelet function and thrombus formation. We have reported previously that the preferred pharmacologically characterized receptor for these peptides, the NK1 receptor, is present on platelets. Inhibition or deficiency of the NK1 receptor, or SP agonist activity, resulted in substantially reduced thrombus formation in vitro under arterial flow conditions, increased bleeding time in mice, and a decrease in experimentally induced thromboembolism. Inhibition of the NK1 receptor may therefore provide benefit in patients vulnerable to thrombosis and may offer an alternative therapeutic target.
Evaluation of Representative Smart Grid Investment Project Technologies: Demand Response (2012)

This document is one of a series of reports estimating the benefits of deploying technologies similar to those implemented on the Smart Grid Investment Grant (SGIG) projects. Four technical reports cover the various types of technologies deployed in the SGIG projects, distribution automation, demand response, energy storage, and renewables integration. A fifth report in the series examines the benefits of deploying these technologies on a national level. This technical report examines the impacts of a limited number of demand response technologies and implementations deployed in the SGIG projects.
Isolation of Tunichrome B-1, a Reducing Blood Pigment of the Sea Squirt, Ascidia nigra (1986)

The tunicates, or sea squirts, are common marine organisms that selectively accumulate metals such as V, Fe, Mo, Nb, in their blood cells. Despite the more than 70 years of interest in the compounds responsible for this accumulation, their extreme lability has eluded attempts to isolate and characterize them. The isolation and structure of the first of these blood pigments tunichrome B-1 from the Ascidia nigra is reported.
Functionalized Nanoporous Gold Leaf Electrode Films for the Immobilization of Photosystem I (2008)

Plants and some types of bacteria demonstrate an elegant means to capitalize on the superabundance of solar energy that reaches our planet with their energy conversion process called photosynthesis. Seeking to harness Nature's optimization of this process, we have devised a biomimetic photonic energy conversion system that makes use of the photoactive protein complex Photosystem I, immobilized on the surface of nanoporous gold leaf (NPGL) electrodes, to drive a photoinduced electric current through an electrochemical cell. The intent of this study is to further the understanding of how the useful functionality of these naturally mass-produced, biological light-harvesting complexes can be integrated with nonbiological materials. Here, we show that the protein complexes retain their photonic energy conversion functionality after attachment to the nanoporous electrode surface and, further, that the additional PSI/electrode interfacial area provided by the NPGL allows for an increase in PSI-mediated electron transfer with respect to an analogous 2D system if the pores are sufficiently enlarged by dealloying. This increase of interfacial area is pertinent for other applications involving electron transfer between phases; thus, we also report on the widely accessible and scalable method by which the NPGL electrode films used in this study are fabricated and attached to glass and Au/Si supports and demonstrate their adaptability by modification with various self-assembled monolayers. Finally, we demonstrate that the magnitude of the PSI-catalyzed photocurrents provided by the NPGL electrode films is dependent upon the intensity of the light used to irradiate the electrodes.
Effects of Combined Chemotherapy on Sarcoma 180, With Special Reference to Food Intake, Body-Weight Changes, and Survival Time<xref ref-type="fn" rid="fn1">2</xref> (1954)

Effects of Combined Chemotherapy on Sarcoma 180, With Special Reference to Food Intake, Body-Weight Changes, and Survival Time Louis Barvick, Louis Barvick Chemistry Research Division, Midwest Research Institute, Kansas City, Mo. Search for other works by this author on: Oxford Academic PubMed Google Scholar Louis H. Goodson Louis H. Goodson Chemistry Research Division, Midwest Research Institute, Kansas City, Mo. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 1, August 1954, Pages 177–189, https://doi.org/10.1093/jnci/15.1.177 Published: 01 August 1954 Article history Received: 19 April 1954 Published: 01 August 1954
Evaluating storage, retention, and retrieval in disordered memory and learning (1974)

Two simple methods that are clinically useful for analyzing impaired memory and learning are selective reminding or restricted reminding. These new methods provide simultaneous analysis of storage, retention, and retrieval during verbal learning because they let the patient show learning by spontaneous retrieval without csnfounding by continual presentation. Because selective reminding and restricted reminding let the patient show consistent retrieval without any further presentation, they also distinguish list learning from item learning, so that impaired memory and learning can be analyzed further in terms of two stages of learning (item and list).
Hyperspectral imaging: comparison of acousto-optic and liquid crystal tunable filters (2018)

In this work, we report a performance comparison of an acousto-optic tunable filter (AOTF), and a liquid crystal tunable filter (LCTF) based on a novel dual-arm hyperspectral imaging (HSI) configuration. The main purpose of this work is to highlight the leverage points of each tunable filter, in order to facilitate filter choice in HSI design. Three main parameters are experimentally examined: spectral resolution, out-of-band suppression, and image quality in the sense of spatial resolution. The experimental results, using wideband illumination, laser lines, and a spatial test target (USAF-1951) emphasized the superiority of AOTF in spectral resolution, out-of –band suppression and random switching speed between wavelengths. The same experiments demonstrated LCTF to have better performance in terms of the spatial image resolution, both horizontal and vertical, and high definition quality. In conclusion, the efficient design of an HSI system is application-dependent. For medical applications, for instance, if the tissue of interest has undefined optical properties, or contains close spectral features, AOTF might be the better option. Otherwise, LCTF is more convenient and simpler to use, especially if the tissue chromophore’s spatial mapping is needed.
Prediction of Therapeutic Responses to Tocilizumab in Patients With Rheumatoid Arthritis: Biomarkers Identified by Analysis of Gene Expression in Peripheral Blood Mononuclear Cells Using Genome‐Wide DNA Microarray (2014)

Using genome-wide DNA microarray analyses, we identified candidate biomarkers that can be used to predict therapeutic responses to tocilizumab in patients with RA. These findings suggest that type I interferon signaling and metallothioneins are involved in the pathophysiology of RA.
Protein and caloric or macronutrient metabolic management of the critically ill patient (1979)

Aggressive and early use of nutritional support therapies in critically ill patients represents a major advance in critical care medicine. The net protein catabolism and erosion of protein stores which is characteristic of the metabolic response to injury results in significant added morbidity and mortality in critical care units. The early administration of appropriate protein and energy in support of enhanced demands will maintain host defense and preserve organ function, thus, allowing time for stabilization of clinical status while life support strategies are implemented. In all circumstances, protein, vitamins, minerals, and nonprotein calories must be provided within fluid and electrolyte restrictions and in conjunction with optimal hemodynamic and pulmonary support.
A Correlation of Ring-Shaped Chromosomes with Variegation in Zea Mays (1932)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
High-speed dynamic 3D photoacoustic imaging of sentinel lymph node in a murine model using an ultrasound array (2009)

Noninvasive photoacoustic sentinel lymph node (SLN) mapping with high spatial resolution has the potential to improve the false negative rate and eliminate the use of radioactive tracers in SLN identification. In addition, the demonstrated high spatial resolution may enable physicians to replace SLN biopsy with fine needle aspiration biopsy, and thus reduce the risk of associated morbidity. The primary goal of this study is to demonstrate the feasibility of high-speed 3D photoacoustic imaging of the uptake and clearance dynamics of Evans blue dye in SLNs. The photoacoustic imaging system was developed with a 30 MHz ultrasound array and a kHz repetition rate laser system. It acquires one 3D photoacoustic image of 166 B-scan frames in 1 s, with axial, lateral, and elevational resolutions of 25, 70, and 200 microm, respectively. With optic-fiber based light delivery, the entire system is compact and is convenient to use. Upon injection of Evans blue, a blue dye currently used in clinical SLN biopsy, SLNs in mice and rats were accurately and noninvasively mapped in vivo using our imaging system. In our experiments, the SLNs were found to be located at approximately 0.65 mm below the skin surface in mice and approximately 1.2 mm in rats. In some cases, lymph vessels and lymphatic valves were also imaged. The dye dynamics--accumulation and clearance--in SLNs were quantitatively monitored by sequential 3D imaging with temporal resolution of as high as approximately 6 s. The demonstrated capability suggests that high-speed 3D photoacoustic imaging should facilitate the understanding of the dynamics of various dyes in SLNs and potentially help identify SLNs with high accuracy.
Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. (1995)

Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder primarily involving motoneurons. A subset of individuals with familial autosomal dominant forms of the disease have mutations of the copper/zinc superoxide dismutase (Cu/Zn SOD, SOD-1) gene, which encodes a ubiquitously expressed enzyme that plays a key role in oxygen free radical scavenging. This observation suggests that altered or reduced SOD-1 activity may play a role in the neurodegenerative process. To explore this possibility further, we have introduced a mutation into the mouse SOD-1 gene that corresponds to one of the changes found in the human gene in familial amyotrophic lateral sclerosis. Integration and expression of this mouse gene in transgenic mice was identified by the presence of a unique restriction enzyme site in the transgene coding sequence generated by introduction of the mutation. We report here that high expression of this altered gene in the central nervous systems of transgenic mice is associated with an age-related rapidly progressive decline of motor function accompanied by degenerative changes of motoneurons within the spinal cord, brain stem, and neocortex. These findings indicate a causative relationship between altered SOD activity and motoneuron degeneration. Moreover, biochemical studies indicate normal levels of total SOD activity in transgenic mouse tissues, results that indicate that the neurodegenerative disorder does not result from a diminution of activity and, as such, represents a dominant "gain of function" mutation.
Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome? (1997)

In human pregnancy, placental cytotrophoblasts that invade the uterus downregulate the expression of adhesion receptors that are characteristic of their epithelial origin, and upregulate the expression of adhesion receptors that are expressed by vascular cells. We suggest that this transformation could be critical to endovascular invasion, the process whereby cytotrophoblasts invade the uterine spiral arterioles and line their walls (Zhou et al. J. Clin. Invest. 1997. 99: 2139-2151.). To better understand the in vivo significance of these findings, we tested the hypothesis that in preeclampsia, an important disease of pregnancy in which endovascular invasion is abrogated, cytotrophoblasts fail to adopt a vascular adhesion phenotype. In experiments described here we stained placental bed biopsy specimens from age-matched control pregnancies and from those complicated by preeclampsia with antibodies that recognize adhesion molecules that are normally modulated during this transformation. In preeclampsia, differentiating/invading cytotrophoblasts fail to express properly many of these molecules, including integrin, cadherin, and Ig superfamily members. These results suggest that preeclampsia is associated with failure of cytotrophoblasts to mimic a vascular adhesion phenotype. The functional consequences of this abnormality are unknown, but are likely to affect negatively cytotrophoblast endovascular invasion and uterine arteriole remodeling, thereby compromising blood flow to the maternal-fetal interface.