gebhart/patrepeval huggingface dataset:
Growing Concern Over Perfluorinated Chemicals (2001)

ADVERTISEMENT RETURN TO ISSUEPREVFeaturesNEXTGrowing Concern Over Perfluorinated ChemicalsEvidence of toxic effects and environmental impacts has sent researchers scrambling to obtain more data.Rebecca RennerCite this: Environ. Sci. Technol. 2001, 35, 7, 154A–160APublication Date (Web):April 1, 2001Publication History Published online1 April 2001Published inissue 1 April 2001https://pubs.acs.org/doi/10.1021/es012317khttps://doi.org/10.1021/es012317knewsACS Publications. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views5182Altmetric-Citations352LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (34 MB) Get e-Alertsclose Get e-Alerts
Adeno-associated virus-mediated delivery of antiangiogenic factors as an antitumor strategy. (1998)

Antiangiogenic tumor therapies have recently attracted intense interest for their broad-spectrum action, low toxicity, and, in the case of direct endothelial targeting, an absence of drug resistance. To promote tumor regression and to maintain dormancy, antiangiogenic agents need to be chronically administered. Gene therapy offers a potential way to achieve sustained therapeutic release of potent antiangiogenic substances. As a step toward this goal, we have generated recombinant adeno-associated virus (rAAV) vectors that carry genes coding for angiostatin, endostatin, and an antisense mRNA species against vascular endothelial growth factor (VEGF). These rAAVs efficiently transduced three human tumor cell lines tested. Transduction with an rAAV-encoding antisense VEGF mRNA inhibited the production of endogenous tumor cell VEGF. Conditioned media from cells transduced with this rAAV or with rAAV-expressing endostatin or angiostatin inhibited capillary endothelial cell proliferation in vitro. Antiangiogenic rAAVs may offer a novel gene therapy approach to undermining tumor neovascularization and cancer progression.
Electro-optic field mapping system utilizing external gallium arsenide probes (2000)

External electro-optic probes fabricated from two different crystal orientations of GaAs have been implemented in an electro-optic sampling system that is capable of mapping three independent orthogonal components of free-space electric fields. The results obtained for the radiated field from a microstrip patch antenna by the GaAs probes are compared with results on the same antenna obtained using bismuth silicate and lithium tantalate probes. An 8 μm spatial resolution has also been demonstrated for the electro-optic field-mapping system, and the capability for the system to measure field patterns at frequencies up to 100 GHz has been shown.
제1분과: 설계/시공 : 제천, 오창 폐기물 매립장 에어돔 구조설계 및 시공 (2007)

폐기물 매립장용 구조물중 에어돔 형식은 가장 경제적이고 효율적인 구조시스템이다. 본사에서 시공한 제천 및 오창 시공사례를 통해서 에어돔 형식에 대해서 알아보고자 한다. 앞으로는 설계·시공·기술적인 측면에서 좀 더 발전된 기술을 접목하여 환경적인 문제뿐만 아니라 미적인 면에서도 주민들과 함께 할 수 있는 구조물을 창출할 수 있는 노력이 필요하리라 생각된다.
Rope-Producing Strains of Bacillus spp. from Wheat Bread and Strategy for Their Control by Lactic Acid Bacteria (2003)

Two types of white wheat bread (high- and low-type loaves) were investigated for rope spoilage. Thirty of the 56 breads tested developed rope spoilage within 5 days; the high-type loaves were affected by rope spoilage more than the low-type loaves. Sixty-one Bacillus strains were isolated from ropy breads and were characterized on the basis of their phenotypic and genotypic traits. All of the isolates were identified as Bacillus subtilis by biochemical tests, but molecular assays (randomly amplified polymorphic DNA PCR assay, denaturing gradient gel electrophoresis analysis, and sequencing of the V3 region of 16S ribosomal DNA) revealed greater Bacillus species variety in ropy breads. In fact, besides strains of B. subtilis, Bacillus licheniformis, Bacillus cereus, and isolates of Bacillus clausii and Bacillus firmus were also identified. All of the ropy Bacillus isolates exhibited amylase activity, whereas only 32.4% of these isolates were able to produce ropiness in bread slices after treatment at 96 degrees C for 10 min. Strains of lactic acid bacteria previously isolated from sourdough were first selected for antirope activity on bread slices and then used as starters for bread-making experiments. Prevention of growth of approximately 10(4) rope-producing B. subtilis G1 spores per cm(2) on bread slices for more than 15 days was observed when heat-treated cultures of Lactobacillus plantarum E5 and Leuconostoc mesenteroides A27 were added. Growth of B. subtilis G1 occurred after 7 days in breads started with Saccharomyces cerevisiae T22, L. plantarum E5, and L. mesenteroides A27.
Conserved Wat1/Pop3 WD-repeat protein of fission yeast secures genome stability through microtubule integrity and may be involved in mRNA maturation (2001)

Accurate chromosome segregation is dependent upon the integrity of mitotic spindles, which pull each pair of sister chromatids towards opposite poles. In this study, we have characterised fission yeast pop3-5235, a diploidising mutant that is impaired in genome stability. Pop3 is the same as Wat1, a conserved protein containing 7 WD repeats. Pop3/Wat1 has also been isolated from a two-hybrid screen as a binding partner to Prp2, the large subunit of the essential splicing factor U2AF. In wat1 mutants, the cellular amount of alpha-tubulin is decreased to very low levels, which results in compromised microtubules and spindles, consequently leading to unequal chromosome separation. Further analysis shows that, in spite of the binding between Wat1 and Prp2, Wat1 may not be involved directly in splicing reactions per se. Instead, we find that Wat1 is required for the maintenance of alpha-tubulin mRNA levels; moreover, transcript levels of genes other than the alpha-tubulin gene are also equally decreased in this mutant. Wild-type Wat1, but not the mutant protein, forms a large complex in the cell with several other proteins, suggesting that Wat1 functions as a structural linker in the complex. The results suggest that Wat1 plays a role in mRNA maturation as a coupling protein between splicing and synthesis and/or stabilisation.
Stereophonic CELP coding using cross channel prediction (2002)

One step towards more realistic speech communication is the move from monophonic to stereophonic sound transmission. Stereophonic speech coding has been explored in the past with the use of cross-channel "cancellation" prediction combined with ADPCM. While this solution and other multi-channel audio techniques can be applied to speech coding there are some fundamental reasons that may limit their use in newer speech coding technologies. This paper investigates the application of cross-channel prediction in the framework of stereophonic code excited linear predictive (CELP) coding.
Interaction Between Pain, Movement, and Physical Activity (2014)

Movement is changed in pain. This presents across a spectrum from subtle changes in the manner in which a task is completed to complete avoidance of a function and could be both a cause and effect of pain/nociceptive input and/or injury. Movement, in a variety of forms, is also recommended as a component of treatment to aid the recovery in many pain syndromes. Some argue it may not be sufficient to simply increase activity, whereas others defend a necessity to consider how a person moves. There is unlikely to be a simple relationship between pain and movement, as both too little and too much movement could be suboptimal for the health of the tissues. The interaction between pain, (re)injury, and movement is surprisingly unclear. Traditional theories to explain adaptation in the motor system in pain are unable to account for the variability observed in laboratory and clinical practice. New theories are required. Treatments that focus on physical activity and exercise are the cornerstone of management of many pain conditions, but the effect sizes are modest. There is limited consensus when, if, and how interventions may be individualized and combined. The aim of this narrative review was to present current understanding of the interaction between movement and pain; as a cause or effect of pain, and in terms of the role of movement (physical activity and exercise) in recovery of pain and restoration of function.
Notas sobre el régimen de transparencia fiscal (2001)

Aparecido con ocasion de la reforma tributaria que tuvo lugar en los anos 1977-1978, el regimen de transparencia fiscal ha sufrido sucesivas mutaciones que, junto con la evolucion del sistema tributario desde aquellas fechas hasta nuestros dias, le han hecho perder su primitiva justificacion y razon de ser. En los momentos actuales no parece tener mas amparo teorico que su potencialidad recaudatoria y, aun esta, se ve mermada en la practica. En consecuencia se considera que este regimen deberia ser objeto de reestructuracion, limitando su aplicacion a aquellos casos en que pueda detectarse una autentica situacion de abuso de la personalidad juridica societaria para eludir el pago del tributo mediante actuaciones fraudulentas.
Intramuscular injection of testosterone undecanoate for the treatment of male hypogonadism: phase I studies (1999)

The longer half-life and the smaller injection volume make TU in castor oil a strong candidate for further applications in substitution therapy and in trials for male contraception.
Ion Channels — Molecular Divining Rods Hit Their Clinical Mark (1997)

Two interesting papers on ion channels appear in this issue of the Journal. In the first, Splawski et al.1 describe the clinical manifestations of a mutation in an ion-channel gene in an extended family. A young girl with congenital hearing loss and severe cardiac dysrhythmia was found to have lost a specific potassium channel (she was homozygous for mutations in KVLQT1), whereas many of her family members had mild prolongation of the QT interval on the electrocardiogram and were heterozygous carriers of the same mutant gene. In the second article, Ackerman and Clapham2 provide a review of ion-channel structure . . .
Curcumin, a component of turmeric: From farm to pharmacy (2013)

Curcumin, an active polyphenol of the golden spice turmeric, is a highly pleiotropic molecule with the potential to modulate the biological activity of a number of signaling molecules. Traditionally, this polyphenol has been used in Asian countries to treat such human ailments as acne, psoriasis, dermatitis, and rash. Recent studies have indicated that curcumin can target newly identified signaling pathways including those associated with microRNA, cancer stem cells, and autophagy. Extensive research from preclinical and clinical studies has delineated the molecular basis for the pharmaceutical uses of this polyphenol against cancer, pulmonary diseases, neurological diseases, liver diseases, metabolic diseases, autoimmune diseases, cardiovascular diseases, and numerous other chronic diseases. Multiple studies have indicated the safety and efficacy of curcumin in numerous animals including rodents, monkeys, horses, rabbits, and cats and have provided a solid basis for evaluating its safety and efficacy in humans. To date, more than 65 human clinical trials of curcumin, which included more than 1000 patients, have been completed, and as many as 35 clinical trials are underway. Curcumin is now used as a supplement in several countries including the United States, India, Japan, Korea, Thailand, China, Turkey, South Africa, Nepal, and Pakistan. In this review, we provide evidence for the pharmaceutical uses of curcumin for various diseases.
Estimating the Number of Clusters in a Data Set Via the Gap Statistic (2001)

Summary We propose a method (the ‘gap statistic’) for estimating the number of clusters (groups) in a set of data. The technique uses the output of any clustering algorithm (e.g. K-means or hierarchical), comparing the change in within-cluster dispersion with that expected under an appropriate reference null distribution. Some theory is developed for the proposal and a simulation study shows that the gap statistic usually outperforms other methods that have been proposed in the literature.
Production of Human Monoclonal Antibodies in Dialysis Tubing (1991)

Human x mouse hybridoma cells were grown in dialysis tubing (DT) to obtain large quantities of human monoclonal antibodies (MAb). Hybridoma cells were grown inside the DT, which was placed in a tissue culture flask containing medium. The medium inside the DT was supplemented with different additives which may be selected depending on the intended use of the MAb. About 10-50 times higher concentrations of immunoglobulin (Ig) were obtained after cultivation in DT compared to conventional tissue culture (CTC) for 2 days. The purity of the MAb was high which facilitated further antibody purification. Production of human MAb in DT proved to be excellent for evaluation studies in laboratory scale. It does not require expensive equipment and several hybridomas can be grown simultaneously.
Directed openings of 2,3-epoxy alcohols via reactions with isocyanates: synthesis of (+)-erythro-dihydrosphingosine (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirected openings of 2,3-epoxy alcohols via reactions with isocyanates: synthesis of (+)-erythro-dihydrosphingosineWilliam R. Roush and Michael A. AdamCite this: J. Org. Chem. 1985, 50, 20, 3752–3757Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://pubs.acs.org/doi/10.1021/jo00220a015https://doi.org/10.1021/jo00220a015research-articleACS PublicationsRequest reuse permissionsArticle Views942Altmetric-Citations129LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparison of clinical outcomes in patients with acute ischemic strokes treated with mechanical thrombectomy using either Solumbra or ADAPT techniques (2015)

In our cohort, the ADAPT technique was associated with significantly higher good clinical outcomes at 90 days in patients with acute ischemic stroke due to anterior circulation ELVOs treated with mechanical thrombectomy.
Evaluation of five temperature‐sensitive mutants of respiratory syncytial virus in primates: I. Viral shedding, immunologic response, and associated illness (1978)

Abstract Approximately 10 4 plaque‐forming units (pfu) of five temperature‐sensitive ( ts ) mutants of respiratory syncytial (RS) virus were administered intranasally to seronegative chimpanzees to evaluate their level of attenuation. When the ts ‐1 mutant was given to two chimpanzees, the pattern of viral growth and illness (rhinorrhea) was similar to that seen during wild‐type RS virus infection. Two further defective subclones of ts ‐1, ts ‐1 NG‐1 and ts ‐1 NG‐16, appeared more attenuated than ts ‐1 with respect to severity of rhinorrhea. The ts ‐7 mutant infected the one animal tested; illness was similar to that induced by ts ‐1 or wild‐type virus. 10 4 pfu of the ts ‐2 mutant failed to infect two chimpanzees; virus was not isolated, a serum antibody response was not detected, and unlike chimpanzees given the other ts mutants, these animals were not resistant to challenge with wild‐type virus. A 40‐fold larger inoculum of ts ‐2, 10 5, 6 pfu, infected each of four chimpanzees, but the peak quantity of virus shed was approximately 500‐fold lower than during wild‐type virus infection. Significantly, the ts ‐2 infected chimpanzees did not become ill, but infection did stimulate the development of RS virus serum neutralizing antibodies. The one chimpanzee given 10 7, 6 pfu of the ts ‐2 mutant shed as much virus as the chimpanzees infected with wild‐type virus; however, there were no signs of upper respiratory tract illness. Owl monkeys resembled chimpanzees in shedding s large amount of virus and developing rhinorrhea following administration of wild‐type virus or the ts ‐1 mutant. Significantly, 10 5, 3 pfu of ts ‐2 infected only one of two owl monkeys tested, but a small quantity of virus (&gt;10 pfu/ml) was shed. These observations suggested that the ts ‐2 mutant was the most attenuated vaccine cadidate strain tested, and that extent of infection with rs ‐2 appeared to be related to the quantity of virus administered.
Profiling and quantitative evaluation of three Nickel-Coated magnetic matrices for purification of recombinant proteins: helpful hints for the optimized nanomagnetisable matrix preparation (2011)

Taken together, functionality of different types of nanomagnetic matrices vary considerably. This variability may not only be dependent upon the structure and surface chemistry of the matrix which in turn determine the affinity of interaction, but, is also influenced to a lesser extent by the physical properties of the protein itself. Although the results of the present study may not be fully applied for all nanomagnetic matrices, but provide a framework which could be used to profiling and quantitative evaluation of other magnetisable matrices and also provide helpful hints for those researchers facing same challenge.
Language model adaptation using mixtures and an exponentially decaying cache (2002)

Presents two techniques for language model adaptation. The first is based on the use of mixtures of language models: the training text is partitioned according to topic, a language model is constructed for each component and, at recognition time, appropriate weightings are assigned to each component to model the observed style of language. The second technique is based on augmenting the standard trigram model with a cache component in which the words' recurrence probabilities decay exponentially over time. Both techniques yield a significant reduction in perplexity over the baseline trigram language model when faced with a multi-domain test text, the mixture-based model giving a 24% reduction and the cache-based model giving a 14% reduction. The two techniques attack the problem of adaptation at different scales, and as a result can be used in parallel to give a total perplexity reduction of 30%.
Los servicios a las familias como motores del crecimiento económico (2000)

En este trabajo se estudia el consumo de servicios realizados por los hogares españoles a partir de las Encuestas de Presupuestos Familiares realizadas durante el periodo 1980-96. Se pretende conocer cuál es la importancia que el consumo en cada uno de los grupos de servicios tiene dentro del presupuesto familiar y analizar en qué medida este consumo está determinado por características socioeconómicas del hogar.
NANOGP8 is a retrogene expressed in cancers (2006)

Nanog is a transcription factor that plays key roles in the self-renewal and maintenance of pluripotency in human embryonic stem (ES) cells. Among Nanog's 11 pseudogenes, NANOGP8 theoretically could be a retrogene, but was considered unlikely as it has not been identified in any expressed sequence tags (ESTs). In this study, we found that NANOGP8 was expressed in several cancer cell lines and in all cancer tissues tested. The complete coding sequence was cloned and the sequence is highly homologous to that of Nanog. We were also able to detect its protein expression using anti-Nanog antibody in recombinant Escherichia coli and some cancer cell lines tested. In addition, expression of NANOGP8 in NIH3T3 cells can promote cell proliferation. The expression of NANOGP8 in cancer cell lines and cancer tissues suggests that NANOGP8 may play important roles in tumorigenesis. This work not only has potential significance in stem cell and cancer research, but it also raises the possibility that some of the human pseudogenes may have regulatory functions.
Biomaterials in Vascular Surgery (1996)

The development of materials to replace or bypass diseased arterial segments has facilitated substantial advances in vascular surgery over the last 40 yr. Porous cloth tubes were first introduced as an arterial substitute in 1952 by Voorhees and colleagues (1). Five years later Edwards and Tapp fabricated bifurcated aortic grafts of braided nylon that were crimped to prevent kinking (2). Newer synthetic prostheses have enabled successful reconstructions in large-diameter, high-flow vessels, such as the aorta and its primary intrathoracic and abdominal branches. In medium-sized (<6mm diameter) and small-diameter arteries (<4mm) bypass or replacement with long segments of textile grafts have results in unacceptable lower long-term patency rates. Small vessel reconstructions presently rely on the use of autogenous veins for coronary artery and below-knee femoropopliteal lesions and for microvascular repair of digital and cerebral vessels. Better determination of the characteristics influencing biomaterial function will allow development of low-flow prostheses for small diameter arteries and venous reconstruction.
Molecular cloning of sequence-specific DNA binding proteins using recognition site probes. (1989)

Genes encoding sequence-specific DNA binding proteins can be isolated by screening lambda gt11 expression libraries with recognition site DNAs. This strategy is derived from that developed for the isolation of genes using antibody probes. Many different genes encoding transcriptional regulatory proteins have been cloned using this strategy. The DNA binding domains of these regulatory proteins contain different structural motifs including the helix-turn-helix, the "zinc finger" and the "leucine zipper". Various aspects of the screening strategy are evaluated and a detailed protocol is provided. In addition to binding site DNAs, protein and nucleotide probes have been successfully used to screen expression libraries. Therefore ligand based expression screening may be quite general in scope.