gebhart/patrepeval huggingface dataset:
Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis (1993)

Multiple sclerosis (MS) is thought to be an autoimmune disease mediated by T lymphocytes that recognize myelin components of the central nervous system. In a 1-year double-blind study, 30 individuals with relapsing-remitting MS received daily capsules of bovine myelin or a control protein to determine the effect of oral tolerization to myelin antigens on the disease. Six of 15 individuals in the myelin-treated group had at least one major exacerbation; 12 or 15 had an attack in the control group. T cells reactive with myelin basic protein were reduced in the myelin-treated group. No toxicity or side effects were noted. Although conclusions about efficacy cannot be drawn from these data, they open an area of investigation for MS and other autoimmune diseases.
Acute kidney injury in cirrhosis (2008)

Specific therapies of AKI depend on the most likely cause and mechanism. Vasoconstrictors are useful bridging therapies in HRS. Ultimately, liver transplantation is indicated in otherwise reasonable candidates in whom AKI does not resolve with specific therapy.
Recognition Properties of Peptides Hydropathically Complementary to Residues 356–375 of the c-raf Protein (1989)

Two peptides with hydropathic complementarity to residues 356-375 of the c-raf protein were synthesized to determine if they recognize the raf-(356-375) peptide as well as the entire protein. One peptide was deduced from the complementary mRNA for the raf protein corresponding to residues 356-375, whereas the other was deduced solely from the amino acid sequence of the 20-mer segment using a computer program able to generate peptide sequences with hydropathic complementarity to a given sequence. Specific binding of both peptides to the raf 20-mer segment was demonstrated when either the raf 20-mer peptide or the complementary peptides were immobilized on a column. Binding affinities were in the millimolar-micromolar range. Identical binding properties were observed with peptides synthesized with either all D- or all L-amino acids, suggesting a lack of conformational dependence. Binding was also unaffected by the presence of 8 M urea or detergents, was dependent on solvent characteristics of pH and ionic strength, and was abolished by the presence of competing peptides in the eluting buffer. Recognition between raf complementary peptides was accompanied by spectral changes in the far and near UV region, as monitored by circular dichroism. Proteolytic degradation was retarded by the binding of these peptides. Once immobilized on a column, these peptides proved useful for the isolation by affinity chromatography of a recombinant c-raf protein from an Escherichia coli crude cell extract.
Antibacterial Activity of Two Alkylamines Integrated an Indane Scaffold: Mimicry of a Complementary Unit on Magainin 2. (1997)

Based on the antibacterial activity of 9-phenylnonylamine (pC9a) against Escherichia coli (ATCC29522) and Staphylococcus aureus (ATCC25923), we have further tested the inhibitory ability of the growth of the bacteria by (+/-)1-(4-aminobutyl)-6-benzylindane (PM2) and (+/-)1-benzyl-6-(4-aminobutyl) indane (PM3), that is, two kinds of 1,6-disubstituted indanes. In an in vitro assay, they showed almost the same antibacterial activities against the bacteria as pC9a, as well as that of magainin 2 analogs (i.e., the peptides MSI-78 and 87-ISM), except in the case of 87-ISM against S. aureus. At the MIC (minimum inhibitory concentration) values, however, their killing rate of E. coli is actually quicker than pC9a. This indicates that an indane scaffold, used as a template to mimic a part of the alpha-helical structure of magainin 2, can accelerate the killing rate. At present, however, it is unknown whether either the hydrophobicity or the alpha-helical structure, or both, of the indane scaffold is involved in accelerating the rate. Moreover, these two indanes also showed stronger antibacterial activity against two strains of Helicobacter pylori (ATCC43526, ATCC43579) than either pC9a or magainin 2 related peptides.
Dual-channel lock-in magnetometer with a single spin in diamond (2013)

We present an experimental method to perform dual-channel lock-in magnetometry of time-dependent magnetic fields using a single spin associated with a nitrogen-vacancy color center in diamond. We incorporate multipulse quantum sensing sequences with phase estimation algorithms to achieve linearized field readout and constant, nearly decoherence-limited sensitivity over a wide dynamic range. Furthermore, we demonstrate unambiguous reconstruction of the amplitude and phase of the magnetic field. We show that our technique can be applied to measure random phase jumps in the magnetic field, as well as phase-sensitive readout of the frequency.
BCoR, a novel corepressor involved in BCL-6 repression (2000)

BCL-6 encodes a POZ/zinc finger transcriptional repressor that is required for germinal center formation and may influence apoptosis. Aberrant expression of BCL-6 due to chromosomal translocations is implicated in certain subtypes of non-Hodgkin's lymphoma. The POZ domains of BCL-6 and several other POZ proteins interact with corepressors N-CoR and SMRT. Here we identify and characterize a novel corepressor BCoR (BCL-6 interacting corepressor), which is expressed ubiquitously in human tissues. BCoR can function as a corepressor when tethered to DNA and, when overexpressed, can potentiate BCL-6 repression. Specific class I and II histone deacetylases (HDACs) interact in vivo with BCoR, suggesting that BCoR may functionally link these two classes of HDACs. Strikingly, BCoR interacts selectively with the POZ domain of BCL-6 but not with eight other POZ proteins tested, including PLZF. Additionally, interactions between the BCL-6 POZ domain and SMRT, N-CoR, and BCoR are mutually exclusive. The specificity of the BCL-6/BCoR interaction suggests that BCoR may have a role in BCL-6-associated lymphomas.
An improved two-stage camera calibration method based on evolution calculation (2008)

According to the calibration of binocular vision, an improved two-stages camera calibration method involved with multi-distortion coefficients is introduced in this paper. It takes the sum of distance in the world coordinate between ground truth 3D points and calculated 3D points as cost function which is optimized by evolution algorithm (EA). The 3D pointspsila coordinate are calculated by the imitated direct linear transformation (DLT) triangulation based on distortion compensation. This strategy can allow the two cameraspsila all parameters being optimized at the same time. Parameters optimization algorithms with genetic algorithm (GA) and particle swarm optimization (PSO) are introduced. Simulation and experiment are made under the same calibration data sets. A comparison for GA, PSO and Levenberg-Marquardt (LM) algorithms are made. The results show that the strategy of taking the 3D reconstruction errors as object function is feasible, the evolution algorithms have much higher calibration precision than that of the LM algorithm.
Adjoint-Based Well-Placement Optimization Under Production Constraints (2008)

Summary Determining the optimal location of wells with the aid of an automated search method can significantly increase a project's net present value (NPV) as modeled in a reservoir simulator. This paper has two main contributions: first, to determine the effect of production constraints on optimal well locations and, second, to determine optimal well locations using a gradient-based optimization method. Our approach is based on the concept of surrounding the wells whose locations have to be optimized by so-called pseudowells. These pseudowells produce or inject at a very low rate and, thus, have a negligible influence on the overall flow throughout the reservoir. The gradients of NPV over the lifespan of the reservoir with respect to flow rates in the pseudowells are computed using an adjoint method. These gradients are used subsequently to approximate improving directions (i.e., directions to move the wells to achieve an increase in NPV), on the basis of which improving well locations can be determined. The main advantage over previous approaches such as finite-difference or stochastic-perturbation methods is that the method computes improving directions for all wells in only one forward (reservoir) and one backward (adjoint) simulation. The process is repeated until no further improvements are obtained. The method is applied to three waterflooding examples.
Recent Developments in the Application of Section 46: Melway and Boral Considered (2001)

The purpose of the Trade Practices Act of 1974 (Cth), and s46 in Part IV and its relevance for Australians is highlighted. When read together it helps to encourage competition among traders. The cases of Melway Publishing Pty Ltd v Robert Hicks Pty Ltd and the Australian Competition and Consumer Commission v Boral Ltd illustrate the application of s46.
Benefit of Time-of-Flight in PET: Experimental and Clinical Results (2008)

TOF leads to a better contrast-versus-noise trade-off than non-TOF but one that is difficult to quantify in terms of a simple sensitivity gain improvement: A single gain factor for TOF improvement does not include the increased rate of convergence with TOF nor does it consider that TOF may converge to a different contrast than non-TOF. The experimental phantom results agree with those of prior simulations and help explain the improved image quality with TOF for patient oncology studies.
Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function. (1998)

Physiologic cell death via apoptosis occurs without inflammation or autoimmunity. Here, we investigated the outcome of the interaction of apoptotic cells with dendritic cells (DCs), which are potent professional APCs. DCs internalized apoptotic cells and processed them for presentation to both MHC class I- and class II-restricted T cells with an efficiency that was dependent upon the number of apoptotic cells. The latter event was accompanied by the autocrine/paracrine secretion of IL-1beta and TNF-alpha, with eventual DC maturation. High numbers of apoptotic cells, mimicking a failure of their in vivo clearance, are therefore sufficient to trigger DC maturation and the presentation of intracellular Ags from apoptotic cells, even in the absence of exogenous "danger" signals.
Silane reductions in acidic media. II. Reductions of aryl aldehydes and ketones by trialkylsilanes in trifluoroacetic acid. Selective method for converting the carbonyl group to methylene (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSilane reductions in acidic media. II. Reductions of aryl aldehydes and ketones by trialkylsilanes in trifluoroacetic acid. Selective method for converting the carbonyl group to methyleneCharles T. West, Stephen J. Donnelly, Dale A. Kooistra, and Michael P. DoyleCite this: J. Org. Chem. 1973, 38, 15, 2675–2681Publication Date (Print):July 1, 1973Publication History Published online1 May 2002Published inissue 1 July 1973https://pubs.acs.org/doi/10.1021/jo00955a022https://doi.org/10.1021/jo00955a022research-articleACS PublicationsRequest reuse permissionsArticle Views3384Altmetric-Citations195LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Exploiting space and location as a design framework for interactive mobile systems (2000)

This article considers the importance of context in mobile systems. It considers a range of context-related issues and focus on location as a key issue for mobile systems. A design framework is described consisting of taxonomies of location, mobility, population, and device awareness. The design framework inorms the construction of a semantic model of space for mobile systems. The semantic model is reflected in a computational model built on a distriuted platform that allows contextual information to be shared across a number of mobile devices. The framework support the design of interactive mobile systems while the platform supports their rapid development.
Phosphorothioate substrates for T4 RNA ligase (1982)

Stereochemical details of the T4 RNA ligase reaction mechanism have been delineated by examining the reactivity of phosphorothioate analogues in the adenosine 5'-triphosphate (ATP) dependent and ATP-independent RNA ligase reactions. Only the SP isomer of the diastereomeric dinucleoside thiopyrophosphate, App(s)I, was active as an activated donor substrate in the ATP-independent RNA ligase reaction. The thiophosphodiester linkage in the ligation product, ApApAp(s)I, that is formed by the reaction of App(s)I (SP) with the oligonucleotide acceptor, ApApA, was shown to have the RP configuration. This indicates that phosphodiester bond formation occurs by a direct, nucleophilic displacement of AMP from App(s)I by the 3'-hydroxyl group of ApApA with inversion of configuration at phosphorus. The adenylylated intermediate, App(s)Ap, that is formed from the phosphorothioate donor, p(s)Ap, in the ATP-dependent RNA ligase reaction was shown to have the same stereochemical configuration as is required for the ATP-independent RNA ligase reaction. These results indicate that RNA ligase maintains a preferred chirality at phosphorus through the adenylylation and ligation steps of the reaction mechanism. An unusual result is the accumulation of adenosine cyclic 2',3'-phosphate 5'-phosphorothioate in the ATP-dependent RNA ligase reaction employing the donor p(s)Ap when the acceptor ApApA is present. This observation suggests that there are two distinct but reactive modes for donor molecules.
Multiplex Assay for Comprehensive Genotyping of Genes Involved in Drug Metabolism, Excretion, and Transport (2007)

This assay generates a comprehensive assessment of a patient's metabolic genotype and is a tool that can provide a more thorough understanding of patient-to-patient variability in pharmacokinetic responses to drugs.
Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition (EMT) in zebrafish (2014)

// Ching-Hung Chen 1 , Dar-Shong Lin 2,3,4,5 , Chieh-Wen Cheng 6 , Chun-Ju Lin 1 , Yu-Kang Lo 6 , Chueh-Chuan Yen 7,8,9 , Alan Yueh-Luen Lee 6 and Chung-Der Hsiao 1,10 1 Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li, Taiwan 2 Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan 3 Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan 4 Mackay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan 5 Mackay Medical College, Taipei, Taiwan 6 National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan 7 Division of Hematology &amp; Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan 8 National Yang-Ming University School of Medicine, Taipei, Taiwan 9 Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan 10 Center for Nanotechnology, Chung Yuan Christian University, Chung-Li, Taiwan Correspondence: Alan Yueh-Luen Lee, email: // Chung-Der Hsiao, email: // Keywords : Cdc6/ c-Myc/ zebrafish /genomic instability/ epithelial to mesenchymal transition Received : May 24, 2014 Accepted : July 11, 2014 Published : July 11, 2014 Abstract Aberration in DNA replication is a major cause to genome instability that is a hallmark of cancer cells. Cell division cycle 6 (Cdc6) and c-Myc have a critical role in the initiation of DNA replication. However, whether their interaction induces epithelial-mesenchymal transition (EMT) and promotes tumorigenesis in in vivo animal model remains unclear. Since using zebrafish as a cancer model has been restricted by the late onset of tumorigenesis and extreme difficulty in transformation on skin, we tried to establish a novel non-melanoma skin model in zebrafish to study their role in tumorigenesis. A stable transgenic zebrafish was created by using tol2 transposon, in which cdc6 and c-myc were co-overexpressed in epidermis driven by a skin-specific krt4 promoter. Intriguingly, co-overexpression of cdc6 and c-myc in transgenic zebrafish skin triggered tumor-like transformation, apoptosis attenuation, genomic instability, and EMT, hallmarks of malignant tumorigenesis. Our findings and other characteristics of zebrafish, including optical clarity and small molecule treatment, provide the future utility of this model for easy and non-invasive detection and for identification of new anti-cancer drug.
Multicast security: a taxonomy and some efficient constructions (1999)

Multicast communication is becoming the basis for a growing number of applications. It is therefore critical to provide sound security mechanisms for multicast communication. Yet, existing security protocols for multicast offer only partial solutions. We first present a taxonomy of multicast scenarios on the Internet and point out relevant security concerns. Next we address two major security problems of multicast communication: source authentication, and key revocation. Maintaining authenticity in multicast protocols is a much more complex problem than for unicast; in particular, known solutions are prohibitively inefficient in many cases. We present a solution that is reasonable for a range of scenarios. This approach can be regarded as a 'midpoint' between traditional message authentication codes and digital signatures. We also present an improved solution to the key revocation problem.
Differential Induction of Adult and Fetal Globin Gene Expression in the Human CML Cell Subline KU-812F/33 (1994)

Various chemicals which are known to have positive effects on differentiation of some erythroid cell lines were tested on a human chronic myelogenous leukemia cell line, KU-812F. Succinic acid, 5-azacytidine, daunomycin, and hemin showed a positive effect. Among them, hemin and 5-azacytidine were the most effective inducers for erythroid differentiation of KU-812F cells. Dimethylsulfoxide, cytosine arabinofuranoside, and sodium n-butyrate showed no effect. In addition, subclone KU-812F/33 derived from the KU-812F cell line showed differential expression of the beta- and gamma-globin genes in the presence of either 2 microM 5-azacytidine or 40 microM hemin. Hemoglobin synthesis in differentiated KU-812F/33 cells was analyzed by isoelectric focusing gel electrophoresis, and S1 mapping analysis of beta- and gamma-globin mRNA was performed. After treatment with 5-azacytidine, the beta-globin gene expression was predominantly enhanced (18.75-fold higher level of beta-globin mRNA). After treatment with hemin, the most notable increase was in the gamma-globin gene expression (1.83-fold higher level of gamma-globin mRNA), while no increment of beta-globin was observed.
Bile Acid Diarrhea: Prevalence, Pathogenesis, and Therapy (2015)

Bile acid diarrhea (BAD) is usually seen in patients with ileal Crohn's disease or ileal resection. However, 25% to 50% of patients with functional diarrhea or diarrhea-predominant irritable bowel syndrome (IBS-D) also have evidence of BAD. It is estimated that 1% of the population may have BAD. The causes of BAD include a deficiency in fibroblast growth factor 19 (FGF-19), a hormone produced in enterocytes that regulates hepatic bile acid (BA) synthesis. Other potential causes include genetic variations that affect the proteins involved in BA enterohepatic circulation and synthesis or in the TGR5 receptor that mediates the actions of BA in colonic secretion and motility. BAs enhance mucosal permeability, induce water and electrolyte secretion, and accelerate colonic transit partly by stimulating propulsive high-amplitude colonic contractions. There is an increased proportion of primary BAs in the stool of patients with IBS-D, and some changes in the fecal microbiome have been described. There are several methods of diagnosing BAD, such as (75)selenium homotaurocholic acid test retention, serum C4, FGF-19, and fecal BA measurement; presently, therapeutic trials with BA sequestrants are most commonly used for diagnosis. Management involves the use of BA sequestrants including cholestyramine, colestipol, and colesevelam. FXR agonists such as obeticholic acid constitute a promising new approach to treating BAD.
Solar Nantenna Electromagnetic Collectors (2008)

This research explores a new efficient approach for producing electricity from the abundant energy of the sun. A nantenna electromagnetic collector (NEC) has been designed, prototyped, and tested. Proof of concept has been validated. The NEC devices target mid-infrared wavelengths, where conventional photovoltaic (PV) solar cells are inefficient and where there is an abundance of solar energy. The initial concept of designing NEC was based on scaling of radio frequency antenna theory. This approach has proven unsuccessful by many due to not fully understanding and accounting for the optical behavior of materials in the THz region. Also, until recent years the nanofabrication methods were not available to fabricate the optical antenna elements. We have addressed and overcome both technology barriers. Several factors were critical in successful implementation of NEC including: 1) frequency-dependent modeling of antenna elements; 2) selection of materials with proper THz properties; and 3) novel manufacturing methods that enable economical large-scale manufacturing. The work represents an important step toward the ultimate realization of a low-cost device that will collect, as well as convert this radiation into electricity, which will lead to a wide spectrum, high conversion efficiency, and low-cost solution to complement conventional PVs.
Study of nicotine demethylation in Nicotiana otophora (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudy of nicotine demethylation in Nicotiana otophoraRalph L. Chelvarajan, Franklin F. Fannin, and Lowell P. BushCite this: J. Agric. Food Chem. 1993, 41, 6, 858–862Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/jf00030a003https://doi.org/10.1021/jf00030a003research-articleACS PublicationsRequest reuse permissionsArticle Views178Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts