gebhart/patrepeval huggingface dataset:
Effect of length, width, and mode on the mass detection sensitivity of piezoelectric unimorph cantilevers (2002)

We have investigated both experimentally and theoretically the resonance frequency change of a piezoelectric unimorph cantilever due to the mass loaded at the tip of the cantilever. The piezoelectric cantilever was composed of a lead zirconate titanate (PZT) layer and a stainless steel layer. The dependence of the resonance frequency shift, Δf, with respect to a loaded mass, Δm, on the cantilever length, L, width, w, and the resonance modes was examined. For Δm much smaller than the effective mass of the cantilever, we showed that Δf/Δm increased with an increasing eigen value, νn2, and decreasing length, L, and decreasing width, w, as Δfn/Δm=−(νn2/4π)(1/L3w)(1/0.23612ρ̃)Ẽ/ρ̃, where Ẽ and ρ̃ are the effective Young’s modulus and effective density of the unimorph cantilever that depends on the thickness fraction, Young’s modulus and density of each of the individual layers. Thus, given the same Ẽ and ρ̃ by maintaining the same layer thickness fractions of the individual layers, Δf/Δm is increased by a factor of α−4 when a cantilever is reduced in size by a factor α in proportion in all dimensions. We also showed that the same scaling relationship can be applied to a strip mass loaded at the tip as well as uniformly distributed mass on the cantilever surface provided that the uniformly distributed mass does not form a continuous solid film rigidly bonded to the cantilever surface.
Andrology: Insulin-like growth factor-I and 2-macroglobulin in seminal plasma correlate with semen quality (1996)

Insulin-like growth factor-I (IGF-I) and alpha 2-macroglobulin (alpha 2-M) are believed to be involved in the development of germ cells. IGF-I is mainly controlled by concentrations of human growth hormone (HGH), influences cell proliferation and differentiation and its action is mediated by insulin-like growth factor-binding proteins (IGFBP), placental protein 14 (PP14) and prostate-specific antigen (PSA). alpha 2-M acts as a broad spectrum proteinase inhibitor and a binding protein for many cytokines and hormones, e.g. inhibin and activin. This study was designed to identify concentrations of these molecules in seminal plasma in normal semen samples of healthy men, correlations with semen quality, the relationship of IGF-I and alpha 2-M with factors affecting male fertility, and whether vasectomy influences the concentrations of these molecules. Concentrations of IGF-I and alpha 2-M in human seminal plasma were related to semen quality, basal concentrations of HGH, testosterone, IGFBP-3, soluble fibronectin receptor (sFNR), PSA and PP14 in seminal plasma and to serum concentrations of luteinizing hormone (LH) and follicle stimulating hormone (FSH). Commercially available assays were used to analyse 69 semen samples of various quality and 11 post-vasectomy samples. IGF-I concentrations in seminal plasma were significantly correlated with the percentage of morphologically normal spermatozoa (r = 0.748, P = 0.00001) and sperm concentration (r = 0.301, P = 0.011), but negatively correlated with serum FSH (r = -0.506, P = 0.00006) and PSA in seminal plasma (r = -0.388, P = 0.00009). Total alpha 2-M was significantly correlated with sperm count (r = 0.423, P = 0.0005), percentage of progressively motile spermatozoa (r = 0.444, P = 0.00019), quality of motility (sperm motile efficiency, r = 802, P = 0.00001) and straight line velocity (r = 0.411, P = 0.0013). Correlation between the sperm concentration and HGH in seminal plasma was weak (r = 0.287, P = 0.015). Vasectomy reduced the concentration of total alpha 2-M (P = 0.00008) and HGH (P = 0.0068) in the seminal plasma; IGF-I was also reduced after vasectomy when the total ejaculate amount was considered. Thus IGF-I and alpha 2-M are significant for the germ cell development: IGF-I in the maturation of spermatozoa and alpha 2-M in progressive motility.
Transformative Power : Meeting the Challenge of Rural Electrification (2005)

This brief is designed to illustrate in summary how a variety of countries have addressed the problems inherent in having successful rural electrification. By providing a snapshot of various programs and the many different ways in which these programs provide electricity to their rural populations, this note attempts to highlight best practices that should be emulated, and those factors that should be avoided.
Morphologic description of great cardiac vein in pigs compared to human hearts (2014)

The morphological and biometric characteristics of the great cardiac vein and its tributaries had not been reported in prior studies, and due to their similitude with those of the human heart, allows us to propose the pig model for procedural and hemodynamic applications.
Derivation of effective and efficient data set with subtractive clustering method and genetic algorithm (2005)

Success of any forecasting model depends heavily on reliable historical data, among others. Data are needed to calibrate, fine tune and verify any simulation model. However, data are very often contaminated with noise of different levels originating from different sources. This study proposes a scheme that extracts the most representative data from a raw data set. Subtractive Clustering Method (SCM) and Micro Genetic Algorithm (mGA) were used for this purpose. SCM does (a) remove outliers and (b) discard unnecessary or superfluous points while mGA, a search engine, determines the optimal values of the SCM's parameter set. The scheme was demonstrated in: (1) Bangladesh water level forecasting with Neural Network and Fuzzy Logic and (2) forecasting of two chaotic river flow series (Wabash River at Mt. Carmel and Mississippi River at Vicksburg) with the phase space prediction method. The scheme was able to significantly reduce the data set with which the forecasting models yield either equally high or higher prediction accuracy than models trained with the whole original data set. The resulting fuzzy logic model, for example, yields a smaller number of rules which are easier for human interpretation. In phase space prediction of chaotic time series, which is known to require a long data record, a data reduction of up to 40% almost does not affect the prediction accuracy.
VLA‐2 mediates the interaction of collagen with endothelium during in vitro vascular tube formation. (1994)

A confluent endothelial monolayer can be induced to form vascular tubes in response to collagen. We investigated possible mechanisms of collagen-induced tube formation by using antibodies to the VLA-2 integrin receptor and protein kinase C inhibitors. Pre-incubation of cells with anti-VLA-2 (which recognises both the alpha 2 and beta 1 chains) and AK7 (which recognises only the alpha 2 chain) showed a dose-dependent inhibition of tube formation. At 50 micrograms/ml, anti-VLA-2 completely inhibited collagen-induced tube formation, whereas AK7 caused only partial inhibition. Both chlorpromazine and trifluoperazine, at concentrations of 10 microM, prevented tube formation (> 40% inhibition). In summary, the VLA-2 integrin receptor plays a role in the induction of tube formation by type I collagen. Protein kinase C may be activated during this process.
A consistent pattern ofRIN1 rearrangements in oral squamous cell carcinoma cell lines supports a breakage-fusion-bridge cycle model for 11q13 amplification (2000)

Gene amplification is a common feature of tumors. Overexpression of some amplified genes plays a role in tumor progression. Gene amplification can occur either extrachromosomally as double-minute chromosomes (dmin) or intrachromosomally in the form of homogeneously staining regions (hsrs). Approximately one-half of our oral squamous cell carcinomas (OSCCs) are characterized by amplification of band 11q13, usually as an hsr located entopically (occurring or situated at the normal chromosomal site, as opposed to ectopically). Using chromosomal fluorescence in situ hybridization (FISH), we confirmed the amplification of the cyclin D1 (CCND1/PRAD1) and fibroblast growth factor types 3 and 4 (FGF3/INT2 and FGF4/HSTF1) genes within the 11q13 amplicon in our series of primary OSCCs and derived cell lines. The human RIN1 gene was isolated as an RAS interaction/interference protein in a genetic selection in yeast and has been described as a putative effector of both the RAS and ABL oncogenes. We mapped RIN1 to 11q13.2. FISH analysis of 10 11q13-amplified OSCC cell lines revealed high-level RIN1 amplification in two cell lines. Three additional cell lines have what appear to be duplications and/or low-level amplification of RIN1, visible in both interphase and metaphase cells. The hybridization pattern of RIN1 on the metaphase chromosomes is particularly revealing; RIN1 signals flank the 11q13 hsr, possibly as a result of an inverted duplication. The gene amplification model of Coquelle et al. (1997) predicted that gene amplification occurs by breakage-fusion-bridge (BFB) cycles involving fragile sites. Our data suggest that the pattern of gene amplification at 11q13 in OSCC cell lines is consistent with a BFB model. RIN1 appears to be a valuable probe for investigating the process of gene amplification in general and, specifically, 11q13 amplification in oral cancer.
Identification of the fibrinogen receptor on human platelets by photoaffinity labeling. (1982)

Fibrinogen binding to receptors on stimulated platelets is a prerequisite for platelet aggregation. In order to identify the platelet fibrinogen receptor, we modified fibrinogen with the photoreactive, heterobifunctional cross-linking reagent methyl 4-azidobenzoimidate (MABI). MABI-fibrinogen was fully clottable and able to support platelet aggregation. To photoaffinity label the fibrinogen receptor, gel-filtered human platelets were incubated at 37 degrees C in the dark with 200 micrograms/ml of MABI-fibrinogen, 10 microM ADP, and 0.5 mM calcium. Irradiation of these platelets with ultraviolet light resulted in the incorporation of MABI-fibrinogen into the platelet surface. Incorporation could be prevented by excess native fibrinogen suggesting that MABI-fibrinogen had interacted with the fibrinogen receptor before photolysis. Examination of the irradiated platelets by sodium dodecyl sulfate polyacrylamide gel electrophoresis revealed that the photoactivated MABI-fibrinogen had been incorporated into a 105,000 molecular weight membrane polypeptide that also contained the PlA1 antigen. Thus, this polypeptide has the characteristics of the membrane glycoprotein IIIa. Previous studies have shown that thrombasthenic platelets lack this glycoprotein and fail to bind fibrinogen after stimulation by ADP. Consequently, our data suggest that glycoprotein IIIa constitutes at least one component of the platelet fibrinogen receptor.
Inhibitors of HCV NS5B Polymerase: Synthesis and Structure—Activity Relationships of N‐Alkyl‐4‐hydroxyquinolon‐3‐yl‐benzothiadiazine Sulfamides. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A novel Parallel Active Filter for Current Pulsation Smoothing on single stage grid-connected AC-PV modules (2007)

The newest technology on decentralised grid-connected PV systems is the "AC-PV Module", which is characterised by a number of clear advantages over conventional large PV systems. Single stage topologies seem to be a rather attractive solution, for these applications, since in generally they are characterised by high efficiency, low cost and simple structure with high reliability due to reduced components count. On the other hand in single-phase AC-PV Module inverters, the power that is transferred to the power network has a large amount of power pulsation at twice line frequency. So a large ripple of voltage and current appears at the PV module output. Taking into account that there is a close correspondence between the power that flows from a PV module and the point of operation, this fact leads to reduced PV power generation. In order to overcome this defect, this paper presents a novel current pulsation smoothing parallel active filter (CPS-PAF) which is independent from the inverter topology and his operation mode. Purpose of the proposed CPS-PAF is the elimination of the low frequency PV current ripple. So the PV module can be operated close enough to the maximum power point and consequently the PV generated electricity power is maximised. The CPS-PAF conception, control and effectiveness are validated by PSpice simulation and experimental results accomplished on a laboratory prototype.
Densely Connected Convolutional Networks (2016)

Recent work has shown that convolutional networks can be substantially deeper, more accurate, and efficient to train if they contain shorter connections between layers close to the input and those close to the output. In this paper, we embrace this observation and introduce the Dense Convolutional Network (DenseNet), which connects each layer to every other layer in a feed-forward fashion. Whereas traditional convolutional networks with L layers have L connections - one between each layer and its subsequent layer - our network has L(L+1)/2 direct connections. For each layer, the feature-maps of all preceding layers are used as inputs, and its own feature-maps are used as inputs into all subsequent layers. DenseNets have several compelling advantages: they alleviate the vanishing-gradient problem, strengthen feature propagation, encourage feature reuse, and substantially reduce the number of parameters. We evaluate our proposed architecture on four highly competitive object recognition benchmark tasks (CIFAR-10, CIFAR-100, SVHN, and ImageNet). DenseNets obtain significant improvements over the state-of-the-art on most of them, whilst requiring less computation to achieve high performance. Code and pre-trained models are available at https://github.com/liuzhuang13/DenseNet .
Effect of Eculizumab on Hemolysis and Transfusion Requirements in Patients with Paroxysmal Nocturnal Hemoglobinuria (2004)

Eculizumab is safe and well tolerated in patients with PNH. This antibody against terminal complement protein C5 reduces intravascular hemolysis, hemoglobinuria, and the need for transfusion, with an associated improvement in the quality of life in patients with PNH.
Glass temperature of copolymers (1959)

Abstract According to a recent theory of the glassy state, chain stiffness is the main determinant of the glass transition. In this paper the theory is applied to the problem of predicting the glass temperatures of copolymers of varying composition and therefore varying chain stiffness. It is found that a simplified treatment leads to an equation which is identical in form to the Gordon–Taylor equation but whose coefficients have a different physical significance. Evaluation of these coefficients requires knowledge of only the structures of the homopolymers. This simplified treatment can be applied to various types of copolymer systems but amounts to more of an approximation in the case of random copolymers of the addition (vinyl) type than in the case of random copolymers of the condensation type. The glass temperatures of the condensation copolymer system polyethylene adipate/terephthalate are predicted within experimental error. The average per cent deviation between theory and experiment for 10 well‐characterized vinyl type copolymer systems is found to be 6.4%. In order to illustrate the applicability of the equation to systems not normally considered as copolymeric, the glass temperatures of the polymer system poly‐ n ‐alkyl methyl methacrylate (varying n ) are correlated.
Thermodynamic analysis of cation incorporation during molecular beam epitaxy of nitride films using metal-rich growth conditions (2007)

The conventional approach to growth of the nitride films GaN, AlN, InN, and their alloys by rf plasma molecular beam epitaxy uses metal-rich surface conditions due to improved material quality compared to nitrogen-rich conditions. The surface metal may incorporate into the growing film, act as a surfactant, and/or react with the underlying film or substrate. Using a simple chemical exchange reaction model and tabulated thermodynamic data at molecular beam epitaxy growth temperatures the predicted preferential incorporation series on the column III site under metal-rich conditions is found to be Al&amp;gt;B,Be,Si, Mg&amp;gt;Ga&amp;gt;In,Fe. This series is consistent with the observed ternary growth behavior and surfactant order. The series is also consistent with silicon migration in AlN but not GaN, sharper beryllium transitions in GaN than AlN, the significant migration of iron in GaN, and the reactivity of AlN nucleation layers with SiC surfaces. The model is used to predict boron incorporation under metal-rich conditions in BGaN and BAlN and should prove useful as a tool in predicting the incorporation behavior of other cations during metal-rich epitaxial growth of nitride films and possibly other materials.
Multi-level phase change memory using slow-quench operation: GST vs. GSST (2009)

In this paper, we demonstrate the use of a slow-quench waveform for multi-level phase change memory operation and compare the use of Ge <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">21</inf> Sn <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</inf> Sb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">15</inf> Te <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">54</inf> (GSST) and Ge <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> Sb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> Te <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</inf> (GST). A faster multilevel operation is possible with the use of GSST, owing to its faster crystallization speed
Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma (2004)

We have previously shown that dysregulation of fibroblast growth factor receptor 3 (FGFR3) by the t(4;14) translocation is a primary event in multiple myeloma (MM) and that activating mutations of FGFR3 are acquired in some cases. We describe here inhibition of wild-type (WT) and constitutively activated mutant FGFR3 autophosphorylation by the small molecule inhibitor, PD173074. Inhibition of FGFR3 in human myeloma cell lines was associated with decreased viability and tumor cell growth arrest. Further, morphologic, phenotypic, and functional changes typical of plasma cell (PC) differentiation, including increase in light-chain secretion and expression of CD31, were observed and this was followed by apoptosis. Finally, using a mouse model of FGFR3 myeloma, we demonstrate a delay in tumor progression and prolonged survival of mice treated with PD173074. These results indicate that inhibition of FGFR3, even in advanced disease associated with multiple genetic changes, may allow the cell to complete its developmental program and render it sensitive to apoptotic signals. In addition, this represents the validation of a therapeutic target in MM that may benefit patients who have a very poor prognosis with currently available treatments.
Transcriptional regulation in pluripotent stem cells by methyl CpG-binding protein 2 (MeCP2) (2013)

Rett syndrome (RTT) is one of the most prevalent female mental disorders. De novo mutations in methyl CpG-binding protein 2 (MeCP2) are a major cause of RTT. MeCP2 regulates gene expression as a transcription regulator as well as through long-range chromatin interaction. Because MeCP2 is present on the X chromosome, RTT is manifested in an X-linked dominant manner. Investigation using murine MeCP2 null models and post-mortem human brain tissues has contributed to understanding the molecular and physiological function of MeCP2. In addition, RTT models using human induced pluripotent stem cells derived from RTT patients (RTT-iPSCs) provide novel resources to elucidate the regulatory mechanism of MeCP2. Previously, we obtained clones of female RTT-iPSCs that express either wild-type or mutant MECP2 due to the inactivation of one X chromosome. Reactivation of the X chromosome also allowed us to have RTT-iPSCs that express both wild-type and mutant MECP2. Using these unique pluripotent stem cells, we investigated the regulation of gene expression by MeCP2 in pluripotent stem cells by transcriptome analysis. We found that MeCP2 regulates genes encoding mitochondrial membrane proteins. In addition, loss of function in MeCP2 results in de-repression of genes on the inactive X chromosome. Furthermore, we showed that each mutation in MECP2 affects a partly different set of genes. These studies suggest that fundamental cellular physiology is affected by mutations in MECP2 from early development, and that a therapeutic approach targeting to unique forms of mutant MeCP2 is needed.
Wearable key: device for personalizing nearby environment (2002)

This paper describes a system that allows users who obtain a "wearable ID key" to personalize dynamically ubiquitous computers by simply touching them. We call the concept of providing personalized service by touch "Active Personalization". For active personalization, users only have to wear a digital key and do not have to carry around other computers. When users touch ubiquitous computers with their wearable key, the keyholes of the ubiquitous computers recognize their IDs and can personalize the computers. We developed a new network technology between keys and keyholes that enables digital information to be carried through a person's body based on a near-field technology we call TouchNet.
Calcium, Magnesium, and Zinc Supplementation and Perinatal Outcome (1991)

The overall importance of nutrition to favorable perinatal outcome is only beginning to be fully appreciated. Although nutritional status can be linked to such things as socioeconomic class and education, it is nutrition directly that exerts a biologic effect. This review has attempted to look at three elements and their relationship to maternal and fetal outcome. At the present time, there does not seem to be a role for routine magnesium supplementation during pregnancy. Magnesium deficiency, as an isolated nutritional deficiency, is rare, and the evidence is, at best, weak that magnesium supplementation reduces the risk of poor perinatal outcome. Zinc deficiency is also a very rare isolated nutritional finding. Our ability to measure zinc accurately, be it in leukocytes or serum, is improving, but the routine use of zinc supplements during pregnancy cannot be recommended at this time. It may be that zinc will be a useful diagnostic marker, rather than a therapeutic intervention. There is substantial evidence that the average American diet does not contain sufficient calcium. An expansive literature continues to grow in the areas of calcium and colon cancer, calcium and breast cancer, calcium and hypertension, and calcium and osteoporosis. Is it possible that our susceptibilities to these problems begin in utero? Obviously, the answer is unknown. What is known is that supplemental calcium to some degree is needed in the diets of most Americans and in about two thirds of pregnant women. Calcium supplementation seems to affect blood pressure favorably and, pending confirmation with larger trials, may significantly reduce prematurity and preeclampsia risk, thus improving perinatal outcome for a large number of our high-risk patients.