gebhart/patrepeval huggingface dataset:
Razor: a low-power pipeline based on circuit-level timing speculation (2004)

With increasing clock frequencies and silicon integration, power aware computing has become a critical concern in the design of embedded processors and systems-on-chip. One of the more effective and widely used methods for power-aware computing is dynamic voltage scaling (DVS). In order to obtain the maximum power savings from DVS, it is essential to scale the supply voltage as low as possible while ensuring correct operation of the processor. The critical voltage is chosen such that under a worst-case scenario of process and environmental variations, the processor always operates correctly. However, this approach leads to a very conservative supply voltage since such a worst-case combination of different variabilities is very rare. In this paper, we propose a new approach to DVS, called Razor, based on dynamic detection and correction of circuit timing errors. The key idea of Razor is to tune the supply voltage by monitoring the error rate during circuit operation, thereby eliminating the need for voltage margins and exploiting the data dependence of circuit delay. A Razor flip-flop is introduced that double-samples pipeline stage values, once with a fast clock and again with a time-borrowing delayed clock. A metastability-tolerant comparator then validates latch values sampled with the fast clock. In the event of timing error, a modified pipeline mispeculation recovery mechanism restores correct program state. A prototype Razor pipeline was designed in a 0.18 /spl mu/m technology and was analyzed. Razor energy overhead during normal operation is limited to 3.1%. Analyses of a full-custom multiplier and a SPICE-level Kogge-Stone adder model reveal that substantial energy savings are possible for these devices (up to 64.2%) with little impact on performance due to error recovery (less than 3%).
Cubic electrodynamic levitation trap with transparent electrodes (1996)

An unconventional electrodynamic suspension system with transparent planar electrodes is described which stably levitates charged solid particles or liquid droplets without the need for feedback control. The system has been used with particles ranging from about 1 to 100 μm diam, under vacuum and within stationary and flowing gases. Operation within low conductivity liquids is possible in principle. The suspension system consists of six transparent conducting electrodes arranged as faces of a hollow cube. Four of these electrodes are driven by a variable-frequency two-phase ac source operating in the low audio frequency range. Advantages of this type of trap for aerosol studies include relatively wide-angle optical access and a geometry naturally suited to the use of three-axis dc crossfields for particle manipulation. Conditions for stable levitation are reviewed as well as methods for determining the radius, mass, charge, and density of a spherical levitated object.
Enhanced Intracellular Delivery and Chemotherapy for Glioma Rats by Transferrin-Conjugated Biodegradable Polymersomes Loaded with Doxorubicin (2011)

A brain drug delivery system for glioma chemotherapy based on transferrin-conjugated biodegradable polymersomes, Tf-PO-DOX, was made and evaluated with doxorubicin (DOX) as a model drug. Biodegradable polymersomes (PO) loaded with doxorubicin (DOX) were prepared by the nanoprecipitation method (PO-DOX) and then conjugated with transferrin (Tf) to yield Tf-PO-DOX with an average diameter of 107 nm and surface Tf molecule number per polymersome of approximately 35. Compared with PO-DOX and free DOX, Tf-PO-DOX demonstrated the strongest cytotoxicity against C6 glioma cells and the greatest intracellular delivery. It was shown in pharmacokinetic and brain distribution experiments that Tf-PO significantly enhanced brain delivery of DOX, especially the delivery of DOX into brain tumor cells. Pharmacodynamics results revealed a significant reduction of tumor volume and a significant increase of median survival time in the group of Tf-PO-DOX compared with those in saline control animals, animals treated with PO-DOX, and free DOX solution. By terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling, Tf-PO-DOX could extensively make tumor cell apoptosis. These results indicated that Tf-PO-DOX could significantly enhance the intracellular delivery of DOX in glioma and the chemotherapeutic effect of DOX for glioma rats.
Modulation of matrix gelatinases and metalloproteinase-activating process in acute kidney rejection. (2003)

Changes in matrix metalloproteinase (MMP) activities would contribute to the accumulation of extracellular matrix during acute kidney allograft rejection. MMP-2 and MMP-9 and other gelatinolytic activities were examined in the rejected graft and the urine of a rat model of acute kidney rejection (orthotopic allotransplantation from a Buffalo donor to a Wistar-Furth recipient) by either zymography or fluorescence assay. MMP-2, membrane type 1 (MT1)-MMP, and tissue inhibitor of metalloproteinase (TIMP)-2 were also examined by immunodetection. The proMMP-2 activity and protein level increased in the graft during rejection when compared with normal Buffalo kidney, whereas activated MMP-2 decreased. TIMP-2 protein levels were markedly decreased and MT1-MMP proteolytic fragments (44-40 kDa) were undetectable. This suggests an altered MT1-MMP-dependent processing of proMMP-2 into active MMP-2 due to a diminished TIMP-2 level in acute kidney rejection. In the urine the overall gelatinolytic activity decreased considerably, although activity associated with an as yet unidentified 78-kDa protein appeared 6 days after transplantation.
Practical parallel algorithms for dynamic data redistribution, median finding, and selection (2002)

A common statistical problem is that of finding the median element in a set of data. This paper presents a fast and portable parallel algorithm for finding the median given a set of elements distributed across a parallel machine. In fact, our algorithm solves the general selection problem that requires the determination of the element of rank i, for an arbitrarily given integer i. Practical algorithms needed by our selection algorithm for the dynamic redistribution of data are also discussed. Our general framework is a distributed memory programming model enhanced by a set of communication primitives. We use efficient techniques for distributing, coalescing, and load balancing data as well as efficient combinations of task and data parallelism. The algorithms have been coded in SPLIT-C and run on a variety of platforms, including the Thinking Machines CM-5, IBM SP-1 and SP-2, Gray Research T3D, Meiko Scientific CS-2, Intel Paragon, and workstation clusters. Our experimental results illustrate the scalability and efficiency of our algorithms across different platforms and improve upon all the related experimental results known to the authors.
Impact of Polymers on Crystal Growth Rate of Structurally Diverse Compounds from Aqueous Solution (2013)

The presence of an effective crystal growth inhibitor in solution is desirable to prolong supersaturation since residual crystalline material in an amorphous formulation resulting from the manufacturing process or formed during storage or dissolution can potentially have a significant impact on the extent and duration of supersaturation. In this study, the effectiveness of a group of chemically diverse polymers, including several recently synthesized cellulose derivatives, on solution crystal growth of three structurally diverse compounds (celecoxib, efavirenz, and ritonavir) was quantified at different extents of supersaturation and compared. Despite the different chemical properties and structures of the model compounds, nonspecific hydrophobic drug–polymer interactions appeared to be important in determining the impact of a given polymer on crystal growth for of all these drug compounds. Specific intermolecular interactions were also found to be important for crystal growth inhibition of celecoxib and efavirenz by the hydrophilic polymer, PVPVA. These interactive forces—hydrophobicity and specific intermolecular interactions—are likely to promote adsorption of the polymer onto the surface of the crystalline drugs, thus influencing crystal growth. The effectiveness of the polymers also depended on the rate of crystallization of the drug molecules. At a similar supersaturation ratio of ∼1.2, ritonavir and celecoxib had slower normalized crystal growth rates (0.20 and 0.91 mg min–1 m–2, respectively), while the normalized crystal growth rate of efavirenz was significantly higher (2.97 mg min–1 m–2), resulting in lower levels of crystal growth inhibition by the polymers for efavirenz.
Distinct Pathways of Mannan-Binding Lectin (MBL)- and C1-Complex Autoactivation Revealed by Reconstitution of MBL with Recombinant MBL-Associated Serine Protease-2 (2000)

Mannan-binding lectin (MBL) plays a pivotal role in innate immunity by activating complement after binding carbohydrate moieties on pathogenic bacteria and viruses. Structural similarities shared by MBL and C1 complexes and by the MBL- and C1q-associated serine proteases, MBL-associated serine protease (MASP)-1 and MASP-2, and C1r and C1s, respectively, have led to the expectation that the pathways of complement activation by MBL and C1 complexes are likely to be very similar. We have expressed rMASP-2 and show that, whereas C1 complex autoactivation proceeds via a two-step mechanism requiring proteolytic activation of both C1r and C1s, reconstitution with MASP-2 alone is sufficient for complement activation by MBL. The results suggest that the catalytic activities of MASP-2 split between the two proteases of the C1 complex during the course of vertebrate complement evolution.
Convergence of Calcium Signaling Pathways of Pathogenic Elicitors and Abscisic Acid in Arabidopsis Guard Cells (2002)

A variety of stimuli, such as abscisic acid (ABA), reactive oxygen species (ROS), and elicitors of plant defense reactions, have been shown to induce stomatal closure. Our study addresses commonalities in the signaling pathways that these stimuli trigger. A recent report showed that both ABA and ROS stimulate an NADPH-dependent, hyperpolarization-activated Ca(2+) influx current in Arabidopsis guard cells termed "I(Ca)" (Z.M. Pei, Y. Murata, G. Benning, S. Thomine, B. Klüsener, G.J. Allen, E. Grill, J.I. Schroeder, Nature [2002] 406: 731-734). We found that yeast (Saccharomyces cerevisiae) elicitor and chitosan, both elicitors of plant defense responses, also activate this current and activation requires cytosolic NAD(P)H. These elicitors also induced elevations in the concentration of free cytosolic calcium ([Ca(2+)](cyt)) and stomatal closure in guard cells. ABA and ROS elicited [Ca(2+)](cyt) oscillations in guard cells only when extracellular Ca(2+) was present. In a 5 mM KCl extracellular buffer, 45% of guard cells exhibited spontaneous [Ca(2+)](cyt) oscillations that differed in their kinetic properties from ABA-induced Ca(2+) increases. These spontaneous [Ca(2+)](cyt) oscillations also required the availability of extracellular Ca(2+) and depended on the extracellular potassium concentration. Interestingly, when ABA was applied to spontaneously oscillating cells, ABA caused cessation of [Ca(2+)](cyt) elevations in 62 of 101 cells, revealing a new mode of ABA signaling. These data show that fungal elicitors activate a shared branch with ABA in the stress signal transduction pathway in guard cells that activates plasma membrane I(Ca) channels and support a requirement for extracellular Ca(2+) for elicitor and ABA signaling, as well as for cellular [Ca(2+)](cyt) oscillation maintenance.
The Transcription Profile of the Bocavirus Bovine Parvovirus Is Unlike Those of Previously Characterized Parvoviruses (2007)

The Bocavirus bovine parvovirus generated a single pre-mRNA from a promoter at its left-hand end; however, the pattern of its alternative polyadenylation and splicing was different from that of other parvoviruses. A large left-hand-end open reading frame (ORF) encoded a nonstructural protein of approximately 95 kDa. An abundant, spliced, internally polyadenylated transcript encoded the viral NP1 protein from an ORF in the center of the genome. Transcripts encoding the capsid proteins were polyadenylated in the right-hand terminal palindrome. This is the first published transcription map of a member of the Bocavirus genus of the Parvovirinae.
Sorafenib, a systemic therapy for hepatocellular carcinoma (2008)

Hepatocellular carcinoma is a lethal disease that requires a multidisciplinary approach and management. Surgical therapy offers long-term survival; however, few patients are candidates. There has been no accepted systemic therapy for this disease until recently. This article briefly discusses the role of RAS/RAF/MEK/ERK signaling pathway in the pathogenesis of the disease and the promising role of sorafenib for advanced disease.
Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes. (1995)

1. Simultaneous fluorescence and whole-cell current measurements using the calcium indicator dye fura-2 were made in HEK 293 cells expressing recombinant glutamate receptor (GluR) channels, and fractional Ca2+ currents (the proportion of whole-cell current carried by Ca2+; Pf) were determined. 2. Cells expressing N-methyl-D-aspartate receptor (NMDAR) channels showed glutamate activated Ca2+ inflow in the voltage range -60 to 40 mV in normal extracellular solution. Ca2+ inflow decreased in a voltage-dependent manner at membrane potentials more negative than -30 mV due to Mg2+ block. Voltage dependence of block at negative potentials was stronger in cells expressing the NR1-NR2A as compared with cells expressing NR1-NR2C subunits. 3. Fractional Ca2+ currents through NMDARs were independent of extracellular Mg2+ and varied between 8.2% (NR1-NR2C subunits) and 11% (NR1-NR2A subunits) in normal extracellular solution (1.8 mM Ca2+) at -60 mV membrane potential. Pf values increased with increasing [Ca2+]o in the range of 0.5-10mM [Ca2+]o in a saturating fashion. 4. In cells expressing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR) subunits which were unedited at the Q/R site of the putative transmembrane segment TM2 (Q-form), or in cells coexpressing unedited and edited subunits (R-form), the glutamate-evoked Ca2+ inflow increased from 20 to -80 mV in an almost linear way. 5. Fractional Ca2+ currents through AMPAR channels depended on subunit composition. Pf values of Q-form homomeric channels at -60 mV and 1.8 mM [Ca2+]o were between 3.2 and 3.9%. They were slightly voltage dependent and increased with [Ca2+]o in the range 1.8-10mM. Pf values in cells co-expressing Q- and R-form subunits were almost one order of magnitude smaller (0.54%). 6. Relative concentrations of Q-form and R-form GluR-B subunit-specific cDNAs used for cell transfection determined the expression of functionally different heteromeric AMPARS. Pf decreased with increasing relative concentration of R-form encoding CDNAs from 3.4 to 1.4%, demonstrating that editing of the Q/R site of GluR-B subunits decreases Ca2+ inflow through heteromeric AMPARs. 7. Cells expressing the GluR-6 subunit of the kainate receptor (KAR) family were characterized by Pf values which depended on the editing in the TM1 and TM2 segments. Pf values were largest for the Q-form (1.55-2.0%) and lowest for R-form channels (< 0.2%), suggesting that Q/R site editing also decreases Ca2+ inflow through KAR channels. Cells co-expressing both subunit forms showed an intermediate value (0.58%).(ABSTRACT TRUNCATED AT 400 WORDS)
Transfection Activity of Polyamidoamine Dendrimers Having Hydrophobic Amino Acid Residues in the Periphery (2004)

We designed poly(amidoamine) dendrimers with phenylalanine or leucine residues at their chain ends. Thereby, we achieved efficient gene transfection of cells through synergy of the proton sponge effect, which is induced by the internal tertiary amines of the dendrimer, and hydrophobic interaction by the hydrophobic amino acid residues in the dendrimer periphery. Dendrimers having 16, 29, 46, and 64 terminal phenylalanine residues were prepared by the reaction of the amine-terminated poly(amidoamine) G4 dendrimer and L-phenylalanine using condensing reagent 1,3-dicyclohexylcarbodiimide. Transfection activity of these phenylalanine-modified dendrimers for CV1 cells, an African green monkey kidney cell line, increased concomitant with the increasing number of the terminal phenylalanine residues, except for the dendrimer with 64 phenylalanine residues, which showed poor water solubility and hardly formed a complex with DNA at neutral pH. However, under weakly acidic conditions, the dendrimer with 64 phenylalanine residues formed a complex with DNA, thereby achieving highly efficient transfection. In contrast, the attachment of L-leucine residues was unable to improve the transfection activity of the parent dendrimer, probably because of the relatively lower hydrophobicity of this amino acid. The phenylalanine-modified dendrimer exhibited a higher transfection activity and a lower cytotoxicity than some widely used transfection reagents. For that reason, the phenylalanine-modified dendrimers are considered to be promising gene carriers.
A Sequential Sampling Strategy to Improve Reliability-Based Design Optimization With Implicit Constraint Functions (2012)

Reliability-based design optimization (RBDO) has a probabilistic constraint that is used for evaluating the reliability or safety of the system. In modern engineering design, this task is often performed by a computer simulation tool such as finite element method (FEM). This type of computer simulation or computer experiment can be treated a black box, as its analytical function is implicit. This paper presents an efficient sampling strategy on learning the probabilistic constraint function under the design optimization framework. The method is a sequential experimentation around the approximate most probable point (MPP) at each step of optimization process. Our method is compared with the methods of MPP-based sampling, lifted surrogate function, and nonsequential random sampling. We demonstrate it through examples.
Theory and experiment on microstrip antennas (1979)

A simple theory based on the cavity model is developed to analyze microstrip antennas. Formulas for numerous canonical shapes are given. In general the theoretically predicted radiation patterns and impedance loci closely agree with those measured for many antennas of various shapes and dimensions investigated thus far. In fact, this theory enables the computation of both patterns and impedance loci with little effort. The input admittance locus generally follows a circle of nearly constant conductance, but its center is shifted to the inductive region in the Smith chart plot. Peculiar properties for the case with degenerate or slightly degenerate eigenvalues are discussed. An accurate formula for determining the resonant frequency of a rectangular microstrip antenna is also given.
IFN-alpha induces homotypic adhesion and Leu-13 expression in human B lymphoid cells (1993)

IFN-alpha influences the recirculation and growth of normal and malignant B lymphocytes, although the mechanisms involved are not currently known. Lymphocyte recirculation is fundamentally dependent on cell-to-cell interactions that are mediated by cell surface adhesion molecules. In this report, we examined the relationship between the effect of IFN-alpha on cell-to-cell adhesion processes and induction of the Leu-13 cell surface protein in established human Daudi B lymphoid cell lines that are either sensitive or resistant to the antiproliferative activity of IFN-alpha. IFN-alpha directly triggered homotypic adhesion of IFN-sensitive Daudi B cells in a time- and dose-dependent manner. In contrast, IFN-alpha had no effect on the cell-to-cell adhesion of IFN-resistant Daudi B cells. The capacity of IFN-alpha to trigger homotypic aggregation correlated directly with the level of induction of the cell surface protein Leu-13 and could be potentiated by anti-Leu-13 mAb. Other cytokines also known to influence the proliferation, differentiation, or recirculation of B lymphocytes such as IFN-gamma, IL-2, IL-4, IL-6, TNF-alpha, and low molecular weight B cell growth factor did not induce either Leu-13 expression or homotypic aggregation of Daudi B cells. The adhesion pathway triggered by the IFN-inducible protein Leu-13 required metabolic energy and an intact cytoskeleton but was not dependent on: 1) new protein synthesis; 2) protein kinase C, protein kinase A, or tyrosine kinase activities; or 3) the function of known adhesion molecules including LFA-1, ICAM-1, CD44, or VLA-4. Taken together, these studies demonstrate a fundamental role for IFN-alpha and the IFN-inducible protein Leu-13 in regulating a novel homotypic adhesion pathway in B lymphocytes, and provide insight into the possible mechanisms by which IFN-alpha regulates biologic processes including recirculation.
A General Framework for Tracking Multiple People from a Moving Camera (2012)

In this paper, we present a general framework for tracking multiple, possibly interacting, people from a mobile vision platform. To determine all of the trajectories robustly and in a 3D coordinate system, we estimate both the camera's ego-motion and the people's paths within a single coherent framework. The tracking problem is framed as finding the MAP solution of a posterior probability, and is solved using the reversible jump Markov chain Monte Carlo (RJ-MCMC) particle filtering method. We evaluate our system on challenging datasets taken from moving cameras, including an outdoor street scene video dataset, as well as an indoor RGB-D dataset collected in an office. Experimental evidence shows that the proposed method can robustly estimate a camera's motion from dynamic scenes and stably track people who are moving independently or interacting.
Understanding the impact of video quality on user engagement (2011)

As the distribution of the video over the Internet becomes main- stream and its consumption moves from the computer to the TV screen, user expectation for high quality is constantly increasing. In this context, it is crucial for content providers to understand if and how video quality affects user engagement and how to best invest their resources to optimize video quality. This paper is a first step towards addressing these questions. We use a unique dataset that spans different content types, including short video on demand (VoD), long VoD, and live content from popular video con- tent providers. Using client-side instrumentation, we measure quality metrics such as the join time, buffering ratio, average bitrate, rendering quality, and rate of buffering events.
Toxicity study of uracil in dogs (1985)

Uracil was administered to male and female dogs for 3 months and to male dogs for 12 months at dose levels of 0, 210, 420, 840 and 1680 mg uracil per kg body weight per day by gavage. While there were minor differences seen in food consumption, water consumption and erythroid parameters between the 3-month and the 12-month studies, it was concluded that there were no adverse effects seen on these parameters nor on body weight, EKG, clinical laboratory studies and organ weights. Pathological observations did not show treatment-related effects.