gebhart/patrepeval huggingface dataset:
Sound equalization in enclosures using modal reconstruction (1995)

The equalization of complex sound pressure in an enclosure is investigated in this paper. The sound field in the enclosure is modeled with the sum of a series of modes. This sound field is controlled by multiple sources distributed in the enclosure so that a certain region in the enclosure has a desired complex sound pressure. First, the optimum solution which minimizes the average potential energy of the error pressure over the region is derived, where the error is defined as the difference between the desired sound pressure and the sound pressure caused by the sources. By using the optimum solution, the achievable best performance can be known for the given region and the source distribution. The optimum solution can also be a useful tool for finding an effective source distribution since the performance of the optimum solution depends only on the source distribution. Furthermore, the eigenvalues of the source coupling matrix, which appears in the derivation of the optimum solution, indicates the effectiveness of the source distribution. The effectiveness of source distribution is discussed with nine examples of source distributions in a two-dimensional enclosure. The multipoint equalization method to approximate the optimum solution is also discussed for the practical use.
Screening for methicillin resistance in Staphylococcus aureus and coagulase-negative staphylococci: an evaluation of three selective media and Mastalex-MRSA latex agglutination (2003)

Laboratory confirmation of MRSA is important for the implementation of infection control; conventional screening culture methods take up to five days for confirmation. The purpose of this study is to ascertain the efficiency of three selective media for growth of methicillin-resistant Staphylococcus aureus (MRSA) before and after enrichment in salt broth, and to evaluate the Mastalex-MRSA latex agglutination kit for detection of methicillin resistance. Screening swabs were collected from 63 patients, yielding 125 S. aureus isolates and 40 coagulase-negative staphylococcus (CNS) isolates. Selective media used were mannitol salt agar (MSA), Baird-Parker agar with ciprofloxacin (BPC) and bromocresol purple (BCPA). Polymerase chain reaction (PCR) for mecA gene detection was used as the reference standard for evaluation of the Mastalex-MRSA assay, which was also evaluated on colonies of S. aureus from the selective media. No significant difference was found in efficiency of MRSA isolation among the selective media. Pre-enrichment in the salt broth did not enhance isolation of MRSA. Methicillin-sensitive S. aureus and CNS were significantly inhibited in all selective media (P<0.05). Only BPC significantly selected out methicillin-resistant CNS (P<0.01). Mastalex-MRSA was 97% specific and sensitive for the detection of MRSA. It was 65% sensitive and 100% specific in detecting methicillin resistance in CNS. In conclusion, all selective media performed equally well (MRSA isolation rate of approximately 80%). Mastalex-MRSA provided rapid and reliable detection of MRSA from selective media, reducing the time required for confirmation of this organism.
Analysis of circulating biomarkers of sunitinib malate in patients with unresectable neuroendocrine tumors (NET): VEGF, IL-8, and soluble VEGF receptors 2 and 3 (2006)

4045 Background: Sunitinib malate (SU11248) is a multitargeted tyrosine kinase inhibitor with antitumor and antiangiogenic activity that specifically inhibits VEGFR, PDGFR, KIT, RET, and FLT3. In a phase II trial of 109 patients with metastatic neuroendocrine tumors (NET), sunitinib treatment was associated with ORR and high rates of SD in patients with carcinoid and pancreatic islet cell tumors (Kulke et al, ASCO 2005). To characterize potential biomarkers of biological response to sunitinib, we analyzed plasma levels of a panel of soluble proteins from patients in this trial. Methods: Patients received sunitinib in 6-week cycles comprised of 50 mg/day for 4 weeks followed by 2 weeks off treatment. Pre-dose plasma samples from 106 patients were obtained on days 1 and 28 of multiple cycles. Plasma levels of VEGF, soluble VEGF receptor 2 (sVEGFR-2), interleukin-8 (IL-8), and a novel biomarker, sVEGFR-3, were measured via ELISA analysis. Results: Plasma levels of each protein were frequently modulated during the course of treatment. At the end of cycle 1, VEGF levels were increased more than 3-fold over baseline in ∼50% of all patients. Average baseline VEGF levels were higher in the islet cell group (62 vs. 40 pg/ml, P = 0.06). In cycle 1, sVEGFR-2 and sVEGFR-3 levels were significantly decreased by ≥30% in ∼60% and 70% of all patients, respectively (P &lt; 0.0001). Levels tended to return to near-baseline after 2 weeks off treatment. The reduction in sVEGFR-3 levels in cycle 1 was, on average, greater in the subset of patients with PR (n=11) compared to others (45% vs. 38%). Overall, there was a 2.2-fold average increase in IL-8 levels by the end of cycle 1, and a larger proportional increase in IL-8 levels in patients exhibiting decreases in tumor size, patients who also tended to have lower baseline IL-8 levels. Further analysis of correlations with pharmacokinetic and clinical parameters is ongoing. Conclusions: Our results suggest that this panel of circulating proteins may be of utility as pharmacodynamic biomarkers of sunitinib activity in patients with advanced NET. sVEGFR-3 may be a novel biomarker of the biological activity of sunitinib in NET, and IL-8 may be of particular interest as a potential predictor of response. [Table: see text]
Bactericidal effects of 310 nm ultraviolet light-emitting diode irradiation on oral bacteria (2017)

Narrowband UVB-LED irradiation exhibited a weak bactericidal effect on oral bacteria but showed low toxicity to gingival epithelial cells. Its irradiation also induces the production of ROS from oral epithelial cells and may enhance bactericidal activity to specific periodontopathic bacteria. It may be useful as a new adjunctive therapy for periodontitis.
High-Breakdown Enhancement-Mode AlGaN/GaN HEMTs with Integrated Slant Field-Plate (2006)

Enhancement-mode (E-mode) AlGaN/GaN high-electron mobility transistors (HEMTs) with integrated slant field-plates were developed for high breakdown voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">BD</sub> ) and low on-resistance (R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</sub> ). Combination of the self-aligned slant field-plate technology for high VBD and self-aligned CF4 plasma treatment for E-mode operation yielded high-performance device with a V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">BD</sub> of 1400V, which is one of the highest reported VBD value among GaN-based E-mode HEMTs. Using the active area of the device, the R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</sub> was calculated to be below 3mOmegamiddotcm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup>
The biological basis of schizophrenia: new directions. (1997)

The desire to understand the pathophysiology of schizophrenia has inspired an explosion in research over the past decade. This review highlights some key studies that have led to fundamental changes in our understanding of this disorder, focusing on the search for genes in schizophrenia, as well as several recent alternatives to the original dopamine hypothesis of schizophrenia. Advances in genetic methodology have allowed schizophrenia researchers to conduct genome-wide searches for susceptibility genes. Although these studies have identified several regions that demonstrate potential linkage with schizophrenia, a definitive genetic cause has not yet been proved. Recent neurochemical hypotheses have focused on the cortical amino acid neurotransmitter systems (i.e., glutamate and GABA), while anatomical studies suggesting abnormal brain development and premorbid functional deficits have led some researchers to propose a neurodevelopmental origin for schizophrenia. A sizable database can be marshaled in support of each of these ideas, but none as yet fully explain the biological basis of schizophrenia.
Nanoarchitectures. 1. Controlled synthesis of phenylacetylene sequences (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNanoarchitectures. 1. Controlled synthesis of phenylacetylene sequencesJinshan Zhang, Jeffrey S. Moore, Zhifu Xu, and Ryan A. AguirreCite this: J. Am. Chem. Soc. 1992, 114, 6, 2273–2274Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/ja00032a060https://doi.org/10.1021/ja00032a060research-articleACS PublicationsRequest reuse permissionsArticle Views859Altmetric-Citations114LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
The nine ages of herpes simplex virus. (2001)

Hippocrates was the first to describe lesions that could have been caused by herpes simplex virus (HSV), but the clinical conditions caused by this virus have only been described in more detail over the past 3 centuries. Most of the key findings relating to HSV infection and treatment have been made since the early 20th Century. These range from discovering some of the mechanisms behind virus latency and reactivation, to the development of the drug aciclovir, which was the first selective inhibitor of HSV replication. This review provides an evolutionary understanding of HSV, but HSV research is still in its golden age. New facts continue to emerge about HSV, and manipulation of the virus is providing much information. Genetic engineering of this virus is likely to have a most significant impact on future medical therapies, which could extend to specialties beyond virology.
Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets (1996)

The involvement of platelets and the c-mpl receptor in the regulation of thrombopoietin (TPO) plasma concentrations and tissue mRNA levels was investigated in both normal mice and mice defective in c-mpl (c-mpl-/-). Although c-mpl-/- mice have fewer platelets and higher plasma TPO activity than normal mice, there was no increase in TPO mRNA levels as measured by an S1 nuclease protection assay. After the intravenous injection of 125I-TPO, specific uptake of radioactivity by the spleen and blood cells was present in the normal mice, but absent in the c-mpl-/- mice. Platelet-rich plasma (PRP) from normal mice was able to bind and internalize 125I-TPO, whereas PRP from c-mpl-/- mice lacked this ability. Analysis of 125I-TPO binding to normal PRP indicated that binding was specific and saturable, with an approximate affinity of 560 pmol/L and 220 receptors per platelet. PRP from normal mice was also able to degrade 125I-TPO into lower molecular weight fragments. After the intravenous injections, c-mpl-/- mice cleared a dose of 125I-TPO at a much slower rate than did normal mice. Injection of washed platelets from normal mice into c-mpl-/- mice resulted in a dramatic, but transient, decrease in plasma TPO levels. These data provide evidence that platelets regulate plasma TPO levels via binding to the c-mpl receptor on circulating platelets.
Application of 3D EMF simulation for development and optimization of alternating phase-shifting masks (2001)

Besides halftone phase shifting masks (HTPSM) in combination with off-axis illumination alternating phase shifting masks (altPSM) are becoming more and more an important resolution enhancement technique. Their obvious benefits can only yield profit in production if certain mask properties like intensity and phase balance are controlled to a requisite extent. In order to achieve production capable masks within a reasonable time and cost frame simulation tools are of essential importance for mask development and manufacturing. Four our studies we employed solid-CM<SUP>TM</SUP>, a 3D EMF (electro magnetic field) simulator that handles arbitrary topographical masks. It is demonstrated by examples that these capabilities are mandatory for altPSM development. In this paper we discuss the effects of various issues relevant for development and manufacturing of altPSM on a basis of systematic 3D EMF simulations. For different balancing options sensitivity to phase errors, mask CD errors and pitch/feature size were investigated. Comparisons to 2D simulation are made for further illustration. We show the influence of certain mask errors on process window and draw conclusions for optimizing altPSM manufacturing.
Retrograde transport from the Golgi complex to the ER of both Shiga toxin and the nontoxic Shiga B-fragment is regulated by butyric acid and cAMP. (1994)

Endocytosed Shiga toxin is transported from the Golgi complex to the endoplasmic reticulum in butyric acid-treated A431 cells. We here examine the extent of this retrograde transport and its regulation. The short B fragment of Shiga toxin is sufficient for transport to the ER. The B fragment of cholera toxin, which also binds to glycolipids, is transported to all the Golgi cisterns, but cannot be localized in the ER even after butyric acid treatment. Under all conditions the toxic protein ricin was found predominantly in the trans-Golgi network. There is no transport of endocytosed fluid to the Golgi apparatus or to the ER even after butyric acid treatment and in the presence of Shiga toxin, indicating that transport to the ER, through the trans-Golgi network and the cisterns of the Golgi apparatus, involves several sorting stations. Since Shiga toxin receptors (Gb3) in butyric acid-treated A431 cells seem to have a ceramide moiety with longer fatty acids than in untreated cells, the possibility exists that fatty acid composition of the receptor is important for sorting to the ER. Both retrograde transport and intoxication with Shiga toxin can also be induced by cAMP, supporting the idea that retrograde transport from the Golgi to the ER is required for intoxication. The data suggest that transport to the ER in cells in situ may depend on fatty acid composition and is regulated by physiological signals.
Inhibitory monoclonal antibodies to human cytochrome P450 1A2: analysis of phenacetin O-deethylation in human liver (1998)

Human cytochrome P450 1A2 metabolizes a large number of common drugs and engages in carcinogen metabolism and activation. Baculovirus-expressed 1A2 was used to immunize mice producing hybridomas yielding monoclonal antibodies (MAbs). Three of 2050 clones assayed yielded the MAbs, MAb 26-7-5, MAb 951-5-1, MAb 1812-2-4, which were specific for 1A2 as assessed by enzyme-linked immunosorbent assay and immunoblots. The three MAbs inhibited 1A2-catalysed metabolism of phenacetin, 7-ethoxycoumarin, chlorzoxazone and phenanthrene by more than 85%. The MAbs were highly specific to 1A2 and did not inhibit 11 other human P450s. The phenancetin O-deethylation activity varied from 0.44-2.49 nmol/min/nmol P450 in eight human liver microsomes samples. MAb 26-7-5 inhibited 1A2-dependent phenacetin O-deethylation in these samples by 64-84% indicating the amount of 1A2 contribution to this reaction and in addition a role for other P450s in the O-deethylation. Independent analysis of recombinant human P450s showed that 1A1, 1A2, 2A6 and 2C19 exhibited phenacetin O-deethylation activity, with 1A1 and 1A2 being the most active followed by 2C19 and 2A6. Eight other P450s were inactive towards phenacetin O-deethylation. The role of different P450 in eight liver samples was analysed with specific individual inhibitory MAbs. Inhibitory antibodies to 1A2, 2C8/9/18/19, 2A6, 2D6, 2E1, and 1A1 were combinatorially added to the microsomes. The O-deethylation activity was inhibited by antibodies to 1A2 (64-84%), to 2C19 (4.6-20%) and to 2A6 (0-8.8%). The total activity inhibited by antibodies to P450 2E1, 2D6 and 1A1 was less than 4.5%, indicating a minor role for these P450s in phenancetin metabolism in human liver microsomes. Thus, 1A2, 2C 9 and 2A6 are the dominant P450s for phenacetin O-deethylation. These studies demonstrate the use of inhibitory MAbs to P450s for a simple and precise assessment of the quantitative role of each P450 in the metabolism of substrates, including drugs, carcinogens, mutagens, environmental chemicals and endobiotics.
Bioassay for homogeneous parasporal crystal of Bacillus thuringiensis using the tobacco hornworm, Manduca sexta (1977)

A method for determining the toxicity of Bacillus thuringiensis subsp. kurstaki parasporal crystal to the tabocco hornworm, Manduca sexta, is described. The use of both mortality and weight loss data have provided a highly sensitive and reproducible bioassay that can be used to compare relative toxicities of crystals from other subspecies as well as toxic components contained therein.
Multifrequency erbium-doped fiber ring lasers anchored on the ITU frequency grid (2003)

Multifrequency erbium-doped fiber lasers anchored on the ITU frequency grid and using periodic filters are presented. The multifrequency operation is obtained by adding a frequency shifter in the ring cavity.
Smart optical receiver with automatic decision threshold setting and retiming phase alignment (1989)

The requirements for a smart optical receiver are discussed, and a design architecture suitable for introducing ICs based on automatic decision threshold setting and retiming phase alignment using digital/analog signal processing feedback is proposed. With the proposed architecture, the decision threshold level and the retiming clock phase of received data in the decision circuit are automatically adjusted to the optimum position. This obviates the need for decision threshold level and retiming clock phase adjustments in production testing, and it reduces the power penalty (receiver sensitivity degradation) on the received optical waveform variation. The power penalty caused by temperature and supply-voltage variations and aging in installation is also reduced. The performance of the proposed architecture is estimated; the power penalty as compared with the manual optimum adjustment is less than 0.4 dB, and the robustness to avalanche photodiode multiplication factor variations and crosstalk are improved.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Dykes on Bikes and the long road to Mardi Gras (2015)

The Sydney Gay and Lesbian Mardi Gras festival is here again. The festival's pinnacle and most attended event, the Parade, will see hundreds of thousands flocking to Sydney's Oxford Street this Saturday for a mix of politics, revealing costumes, buffed bodies, flamboyance and celebration. As is tradition, the sounds of more than 100 Dykes on Bikes revving their engines and blasting their horns will mark the beginning of the party. For the Queensland Dykes on Bikes, however, Mardi Gras is about more than leading the parade and attending parties. Much interest in Mardi Gras is given to its historical legacy, to commodification and to questions of political identity. Seeking to build on these conversations, for the past three years I have been documenting the personal stories of those who travel vast distances each year to attend this event. As part of this research, in a new article, published in Australian Geographer, I sought to examine the complex relations between the Queensland Dykes on Bikes and the Mardi Gras Parade.
Effects of GM1 ganglioside treatment on pre- and postsynaptic dopaminergic markers in the striatum of parkinsonian monkeys (2000)

GM1 ganglioside administration has previously been shown to increase striatal dopamine levels and to enhance the density of tyrosine hydroxylase-positive fibers in the striatum of monkeys made parkinsonian by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The present study examined the extent to which GM1 administration promotes recovery of dopamine terminals and reverses lesion-induced changes in postsynaptic receptors in the striatum of MPTP-treated monkeys. All MPTP-treated animals developed severe parkinsonism. GM1-treated monkeys exhibited significant functional recovery after 6 weeks of treatment, whereas saline-treated controls remained parkinsonian over the same time period. MPTP exposure resulted in profound decreases in [(3)H]-mazindol binding to dopamine transporters in the caudate and putamen and increased D1 and D2 receptor binding in several striatal regions. GM1 treatment resulted in significant increases in striatal [(3)H]-mazindol binding and decreases in D1 binding compared to control animals in many striatal regions. GM1 treatment did not significantly affect D2 binding. These results show that GM1 treatment can partially restore striatal dopaminergic terminals and partially reverse postsynaptic changes in dopamine receptors in a nonhuman primate model of parkinsonism.
Costimulation Blockade-Induced Cardiac Allograft Tolerance: Inhibition of T Cell Expansion and Accumulation of Intragraft cD4+Foxp3+ T Cells (2006)

These results indicate that T-cell derived IL-10 is not essential for induction of graft acceptance in mice treated with costimulation blockade, but that treatment limits T-cell expansion in the recipients. The results further indicate that tolerance is maintained by intragraft CD4(+)Foxp3(+) T cells.
Nucleophilic Aromatic Substitution on Tricarbonylchromium-complexed Haloarenes: Synthesis ofO-Aryloximes and Their Cyclization to Benzofurans (1987)

A series of O-aryloximes have been prepared from tricarbonylchromium-complexed haloarenes in mild conditions. Title compounds are starting materials for benzofuran synthesis.
Estimation of intra-abdominal pressure by bladder pressure mesurement (2011)

Povecanje intraabdominalnof tlaka odnosno intraabdominalna hipertenzija najcesce se javlja kod bolesnika s opstrukcijom crijeva, krvarenjem, masivnim ascitesom, upalnim promjenama u trbuhu te kod traumatskih ozljeda trbusnih organa i jedan je od glavnih uzroka povecanog morbiditeta i mortaliteta bolesnika u jedinicama intenzivnog lijecenja. Buduci da je izravno mjerenje intraabdominalnog tlaka (IAT) vrlo neprakticno, mjerenje intravezikalnof tlaka (IVT) cesto se koristi kao neizravna metoda procjene IAT. Cilj ovog preliminarnog istraživanja je utvrditi povezanost između IAT i IVT. U istraživanje smo ukljucili 14 bolesnika predviđenih za laparoskopsko odstranjenje žucnjaka. Pratili smo promjene tlaka mokracnog mjehura kod postepenog povecanja intraabdominalnog tlaka od 0, 5, 10 i 15 mmHg. Dobiveni rezultati su pokazali da postoji statisticki znacajna pozitivna međuovisnost između IAT i IVT (0, 9757 ; p<0.000).