gebhart/patrepeval huggingface dataset:
The Addition of Sulfhydryl Derivatives to 2-Methyl-1,4-naphthoquinone1 (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Addition of Sulfhydryl Derivatives to 2-Methyl-1,4-naphthoquinone1Louis F. Fieser and Richard B. TurnerCite this: J. Am. Chem. Soc. 1947, 69, 10, 2335–2338Publication Date (Print):October 1, 1947Publication History Published online1 May 2002Published inissue 1 October 1947https://pubs.acs.org/doi/10.1021/ja01202a025https://doi.org/10.1021/ja01202a025research-articleACS PublicationsRequest reuse permissionsArticle Views134Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A further analysis of memory loss in dementia and depression in the elderly (1981)

Groups of normal, depressed and dementing elderly subjects were investigated for their ability to remember serially presented words and pictures in an immediate free recall design. Both the clinical groups showed memory loss, the demented being the more severe. A qualitative analysis of serial position curves suggests that whilst in depression there is probably a suppression of otherwise normal memory processes in dementia there is a more fundamental breakdown in the process itself.
Silencing of gene expression: implications for design of retrovirus vectors (2001)

Transcriptional silencing of retroviruses poses a major obstacle to their use as gene therapy vectors. Silencing is most pronounced in stem cells which are desirable targets for therapeutic gene delivery. Many vector designs combat silencing through cis-modifications of retroviral vector sequences. These designs include mutations of known retroviral silencer elements, addition of positive regulatory elements and insulator elements to protect the transgene from negative position effects. Similar strategies are being applied to lentiviral vectors that readily infect non-dividing quiescent stem cells. Collectively these cis-modifications have significantly improved vector design but optimal expression may require additional intervention to escape completely the trans-factors that scan for foreign DNA, establish silencing in stem cells and maintain silencing in their progeny. Cytosine methylation of CpG sites was proposed to cause retroviral silencing over 20 years ago. However, several studies provide evidence that retrovirus silencing acts through methylase-independent mechanisms. We propose an alternative silencing mechanism initiated by a speculative stem cell-specific "somno-complex". Further understanding of retroviral silencing mechanisms will facilitate better gene therapy vector design and raise new strategies to block transcriptional silencing in transduced stem cells.
On the expected complexity of sphere decoding (2001)

The problem of finding the least-squares solution to a system of linear equations where the unknown vector is comprised of integers, but the matrix coefficient and given vector are comprised of real numbers, arises in many applications: communications, cryptography, GPS, to name a few. The problem is equivalent to finding the closest lattice point to a given point and is known to be NP-hard. In communications applications, however, the given vector is not arbitrary, but rather is an unknown lattice point that has been perturbed by an additive noise vector whose statistical properties are known. Therefore in this paper, rather than dwell on the worst-case complexity of the integer-least-squares problem, we study its expected complexity, averaged over the noise and over the lattice. For the "sphere decoding" algorithm of Fincke and Pohst (1995) we find a closed-form expression for the expected complexity and show that for a wide range of noise variances the expected complexity is polynomial, in fact often sub-cubic. Since many communications systems operate at noise levels for which the expected complexity turns out to be polynomial, this suggests that maximum-likelihood decoding, which was hitherto thought to be computationally intractable, can in fact be implemented in real-time-a result with many practical implications.
Bis-steroids as potential enzyme models: perylene solubilisation and dye spectral changes with aqueous solutions of some derivatives of conessine and cholic acid (1977)

Several bis-steroids derived from conessine or cholic acid solubilise perylene into aqueous solution without evidence of micelle formation, and cause spectral changes in aqueous pinacyanol iodide; mono-steroids examined show these effects (characteristic of hydrophobic interaction) only on micellisation or not at all.
TOCOLYTICS FOR PRETERM LABOR (1999)

In Brief Objective To examine the effectiveness of any tocolytic compared with a placebo or no tocolytic for preterm labor. Data Sources We checked MEDLINE (1966–1998) and the Cochrane Controlled Trials Register for articles, using the search terms “randomized controlled trial” (RCT), “preterm labor,” “tocolysis,” “betamimetics,” “ritodrine,” “terbutaline,” “hexaprenaline,” “isoxuprine,” “prostaglandin synthetase inhibitors,” “indomethacin,” “sulindac,” “calcium channel blockers,” “nifedipine,” “oxytocin receptor blockers,” “atosiban,” “nitroglceride,” and “magnesium sulfate.” Methods of Study Selection We included all RCTs that compared effect of a tocolytic with a placebo or no tocolytic in women in preterm labor, and reported perinatal, neonatal, or maternal outcomes. Studies were excluded if loss to follow-up exceeded 20% of those originally enrolled, or if data were not reported on a per-patient-treated basis. Eighteen of 76 articles retrieved met the inclusion criteria. Tabulation, Integration, and Results Two authors independently reviewed the articles and abstracted the data. Discrepancies were resolved by consensus. Meta-analyses (odds ratio [OR] and 95% confidence interval [CI]) were done for each outcome for all trials and for specific types of tocolytic therapy when possible. Tocolytics decreased the risk of delivery within 7 days (OR 0.60, 95% CI 0.38, 0.95). Betamimetics, indomethacin, atosiban, and ethanol, but not magnesium sulfate, were associated with significant prolongations in pregnancy. Tocolytics were not associated with improved perinatal outcomes. Maternal side effects significantly associated with tocolytic use were palpitations, nausea, tremor, chorioamnionitis, hyperglycemia, hypokalemia, and need to discontinue treatment. Conclusion Although tocolytics prolong pregnancy, they have not been shown to improve perinatal or neonatal outcomes and have adverse effects on women in preterm labor. Tocolytics for preterm labor prolong pregnancy but do not improve perinatal or neonatal outcomes.
Comparative analysis of NFAT (nuclear factor of activated T cells) complex in human T and B lymphocytes (1993)

Nuclear factor of activated T cells (NFAT) is a transcriptional activator that binds to sequences in the interleukin-2 (IL-2) promoter and is thought to be largely responsible for the T cell-specific inducibility of IL-2 expression. Electrophoretic mobility shift assays (EMSA) showed that specific NFAT binding activity could also be induced in human B cells. The B cell NFAT complex, however, was not functional, since it failed to activate transcription from an NFAT-driven chloramphenicol acetyltransferase (CAT) construct. Competition with an AP-1 motif or with anti-Jun and anti-Fos antibodies abolished binding to the NFAT motif in both T and B cells, indicating that Jun and Fos are critical for NFAT complex formation in both cell types. Purified recombinant Jun and Fos proteins failed to bind directly to the NFAT motif. However, when combined with unstimulated B or T cell extracts, full-length, but not truncated, Jun/Fos heterodimers were able to form an NFAT complex, indicating the presence of a constitutively expressed nuclear factor(s) in B and T cells necessary for the formation of the NFAT complex in both cell types. An NFAT oligonucleotide carrying mutations in the 5' purine-rich part of the NFAT sequence failed to form a complex and to compete with the wild type motif for NFAT complex formation in both T and B cells. We therefore propose a model whereby a core NFAT complex consisting of Jun, Fos, and a constitutive nuclear factor is formed in both T and B cells, but an additional factor and/or post-translational modification of a factor, missing in B cells, might be required for transactivation by NFAT.
An arcing fault detection technique using low frequency current components-performance evaluation using recorded field data (1988)

Several low frequencies of the current waveform in distribution feeders exhibit modified behavior under fault conditions. Two frequencies, 180 Hz and 210 Hz, were selected for study owing to the strong magnitude variations associated with arcing faults at these frequencies. A hierarchical algorithm with adaptive characteristics is presented along with the performance results for its application at these low frequencies. The various parameters that affect the sensitivity of the algorithm are discussed. The results of tests using recorded field data are given, and the effects of using a digital filter front end for the algorithm are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Acoustic microscopy of red blood cells. (1988)

We used a scanning acoustic microscope to image normal and outdated red blood cells, cells with different hemoglobin content, red cell ghosts, and cells treated with various drugs that induce echinocyte-stomatocyte transformation. Images were obtained at different planes of focus within the cells, corresponding to maxima and minima of signal intensity. Digitization and gray scale amplitude mapping were used to create axonometric plots that display signal amplitude variations within the cells. The images of red cells contain features produced by differences in topology, density, elasticity, and absorption. Both hemoglobin content and the cell cytoskeleton contribute to image features, and various deformations, characterized by the formation of blebs and vacuoles, are displayed in cells undergoing echinocyte-stomatocyte transformation. These preliminary findings, although mainly descriptive, indicate that acoustic microscopy may be a useful new method for evaluating red cell deformation and associated changes in mechanical properties.
Local Exchange and Trading Systems: A New Source of Work and Credit for the Poor and Unemployed? (1996)

In this paper the aim is to evaluate critically the potential of local exchange and trading systems (LETS) as a new source of work and credit for the poor and unemployed. LETS are local associations whose members list their offers of and requests for goods and services in a directory and then exchange them priced in a local unit of currency. From the results of a national survey of LETS, it is found that LETS are growing rapidly and that a high proportion of the national membership are poor and unemployed. With use of a membership survey of Manchester LETS, it is then revealed that, although the poor and unemployed are capitalising on LETS to gain access to work and credit, it is utilised mainly by what can be called the ‘disenfranchised middle class’. In this paper it is advocated that, for a wider cross-section of the poor and unemployed to become involved, changes are needed not only in the internal operating environment of LETS but also in the approach of the government towards benefit claimants working on such systems.
Transport Properties of Ions in Gases (1988)

Presents thorough coverage of the transport properties of ions in gases. Starts from first principles, making this book useful to those new to the field as well as to experts. Describes the motions of ions in gases in electric fields, methods for measuring mobilities and diffusion coefficients, and pitfalls in measuring these quantities. Provides a detailed development of the theory of transport processes in the context of the kinetic theory of gases. Includes relevant experimental techniques and an index to experimental data.
Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas (2011)

Olesen UH, Hastrup N, Sehested M. Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas. APMIS 2011; 119: 296–303. The purpose of the study was to determine in human malignant lymphomas the expression patterns of nicotinamide phosphoribosyltransferase (NAMPT) and nicotinic acid phosphoribosyltransferase (NAPRT), the primary, rate‐limiting enzymes in the synthesis of NAD+. NAMPT is a potential biomarker for sensitivity to NAMPT inhibitors and NAPRT is a biomarker for the use of nicotinic acid as a chemoprotectant in treatment with NAMPT inhibitors. The NAMPT inhibitor, APO866, is currently in clinical phase II trials in lymphomas. The expression of NAMPT and NAPRT was investigated in 53 samples of malignant lymphomas (diffuse large B‐cell lymphoma, follicular B‐cell lymphoma, Hodgkin’s lymphoma and peripheral T‐cell lymphoma). The expression of NAMPT was generally high in the more aggressive malignant lymphomas, with &gt;80% strong expression, whereas the expression in the more indolent follicular lymphoma (FL) was significantly lower (&gt;75% moderate or low expression, p = 0.0002). NAMPT was very highly expressed in Hodgkin Reed‐Sternberg cells in Hodgkin’s lymphoma. NAPRT expression was more varied (p &gt; 0.0001) with 30–50% low expression except for Hodgkin’s lymphoma where 85% displayed low expression (p = 0.0024). In conclusion, FL are a promising target for NAMPT inhibitors whereas substantial subsets of malignant lymphomas especially in Hodgkin lymphoma may be suitable for a combination treatment with nicotinic acid and NAMPT inhibitors.
A precompetitive consortium on wide-band all-optical networks (1993)

The technical core of a precompetitive consortium formed by AT&T, DEC, and MIT to study the technology, architecture and applications of wideband all-optical networks of local to national (or international) extent is described. A general introduction to all-optical networks is given, and some proposed applications are discussed. The architecture, technology and testbed portions of this effort are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
SCL, the gene implicated in human T-cell leukaemia, is oncogenic in a murine T-lymphocyte cell line. (1993)

SCL (TAL-1) is implicated in the generation of human T-cell acute lymphoblastic leukaemia. To directly examine the role of this putative oncogene, an SCL retrovirus was constructed and used to infect a v-ABL transformed T-lymphocyte cell line. Thirteen independent SCL-infected and four control cell lines were established and injected subcutaneously into syngeneic mice. Mice injected with SCL-infected clonal cell lines died significantly more rapidly than control animals. By day 200 46% (40/87) of animals injected with SCL-infected cell lines had died due to disseminated transplantable lymphoid tumours. In contrast only 22% of control mice were dead by day 200 (P < 0.0015). Of possible relevance to the enhanced tumourigenesis, some SCL-infected cell lines displayed increased clonogenicity in agar. Increased cell growth was even more striking when ex-vivo tumour-derived cell lines were studied. Thus, SCL can co-operate with v-ABL to hasten T-cell tumourigenesis. This is the first direct evidence demonstrating that SCL can behave as an oncogene.
Desorption Ionization of Biomolecules on Metals (2008)

Direct desorption ionization of various types of biomolecules on metal substrates without the need of matrices was observed by a time-of-flight mass spectrometer. It provides a new convenient method for detection of small biomolecules without the confusion of ion peaks from matrix compounds. Simple commercial Al foil can be used as the substrate to obtain mass spectra of biomolecules without the need of an etching process to produce a porous surface such as with direct ionization on silicon (DIOS). The desorption and ionization mechanism is also discussed.
Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics (2016)

A main challenge in realizing the full potential of nucleic acid therapeutics is efficient delivery of them into targeted tissues and cells. N-acetylgalactosamine (GalNAc) is a well-defined liver-targeted moiety benefiting from its high affinity with asialoglycoprotein receptor (ASGPR). By conjugating it directly to the oligonucleotides or decorating it to a certain delivery system as a targeting moiety, GalNAc has achieved compelling successes in the development of nucleic acid therapeutics in recent years. Several oligonucleotide modalities are undergoing pivotal clinical studies, followed by a blooming pipeline in the preclinical stage. This review covers the progress of GalNAc-decorated oligonucleotide drugs, including siRNAs, anti-miRs, and ASOs, which provides a panorama for this field.
Amifostine pretreatment for protection against cyclophosphamide-induced and cisplatin-induced toxicities: results of a randomized control trial in patients with advanced ovarian cancer. (1996)

Pretreatment with amifostine reduces the cumulative hematologic, renal, and neurologic toxicities associated with the CP regimen, with no reduction in antitumor efficacy.
Pathogenesis of psoriatic arthritis (2005)

Purpose of review Heterogeneity in clinical presentation and disease course has hindered understanding of disease mechanisms in psoriatic arthritis, but recent studies have provided insights into pathogenesis. This review examines relevant animal models and genetic factors implicated in disease susceptibility. Also, recent reports on mechanisms related to synovial and entheseal inflammation are discussed. Recent findings Two transgenic mouse models (amphiregulin, STAT-3) were reported that have features of psoriatic arthritis and psoriasis respectively. Genetic studies did not find associations between psoriatic arthritis and several class I major histocompatibility complex alleles, the caspase-activating recruitment domain 15 domain, or the major histocompatibility complex class I chain-related gene A9 allele, in sharp contrast to previous reports. The striking association of psoriatic arthritis with mutations in the killer immunoglobulin receptors on natural killer cells is particularly exciting but needs further study. Psoriatic arthritis has histopathologic features that are more characteristic of other forms of spondyloarthritis than rheumatoid arthritis. Moreover, several of these features correlate with clinical disease activity. Matrix metalloproteinases are strongly expressed in psoriatic arthritis synovium, and serum matrix metalloproteinases-3 may be a reliable biomarker for monitoring disease response. Finally, the concept of an ‘enthesis organ’ may explain the magnetic resonance imaging findings and clinical signs of psoriatic enthesitis and dactylitis. Summary Recent findings highlight the importance of innate immune mechanisms in disease pathogenesis. Moreover, psoriatic arthritis and rheumatoid arthritis synovium have divergent histopathologic features that indicate distinct disease mechanisms. The generation of appropriate animal models coupled with reliable biomarkers will result in a deeper understanding of disease pathogenesis and will facilitate the identification of new therapeutic targets.
Rapid Antidepressant Effect of Ketamine Anesthesia During Electroconvulsive Therapy of Treatment-Resistant Depression (2010)

The results suggested that it is possible to improve symptoms of depression earlier by using ketamine anesthesia.
Progress in Developments of Triplex-Based Strategies (1997)

Recognition of B-DNA by oligonucleotides that form triple helices is a unique method to specifically recognize sequences of double-stranded DNA. Recently, some significant limitations of the triple-based applications have been overcome. Stable intermolecular triplexes can be formed under physiologic conditions. Binding affinities of modified oligonucleotides to their target sequence due to Hoogsteen or reverse Hoogsteen hydrogen bonding interactions are now in the range of those obtained for duplex formation via Watson-Crick hydrogen bonding interactions even if the kinetics may be quite different. Progress has been made toward developing general procedures to determine the molecular mechanisms of action of triplex-forming oligonucleotides (TFO) administered to cultured cells to provide a rational proof-of-concept for antigene strategies. The antigene strategy has reached a point where TFOs can be used to interfere with several biologic progresses (replication, transcription, recombination, repair) in relevant systems both in vitro and ex vivo.
Microsurgical Anatomy of the Venous Drainage into the Superior Sagittal Sinus (1989)

Ten unfixed human brains were examined under an operating microscope to evaluate the feasibility of reimplanting the parasagittal veins into the superior sagittal sinus. On average, there were 6.5 veins draining the surface of each hemisphere in the anterior frontal region, 3 veins draining each posterior frontal region, 4 veins draining each parietal region, and 1 vein draining each occipital region. The veins were most frequently 0.1 to 1.0 mm in diameter, but were as large as 3.0 mm in the anterior frontal and occipital regions, 3.5 mm in the parietal region, and 5.0 mm in the posterior frontal region. The mean vein length between the superior sagittal sinus and the first lateral attachment was 3.0 to 7.4 mm; individual veins were as long as 30.0 mm. The 20 hemispheres contained a total of 5 veins in the anterior frontal region, 7 veins in the posterior frontal region, and 8 veins in the parietal region that appeared to have an adequate diameter and length for microsurgical reimplantation into the superior sagittal sinus. The superior sagittal sinus had a mean width of 4.3 mm and depth of 3.6 mm in the midanterior frontal region and enlarged to a mean width of 9.9 mm and depth of 6.8 mm in the midoccipital region. In all sites, the sinus appeared to be structurally compatible with vein reimplantation. In 3 cases, veins 2.8 to 4.6 mm in diameter were reimplanted microsurgically into the sinus; in each case, the anastomosis was technically satisfactory and patient.(ABSTRACT TRUNCATED AT 250 WORDS)
The cause of the Chinese sofa/chair dermatitis epidemic is likely to be contact allergy to dimethylfumarate, a novel potent contact sensitizer (2008)

The cause of the Chinese sofa/chair dermatitis epidemic is likely to be contact allergy to dimethylfumarate, a novel potent contact sensitizer.