gebhart/patrepeval huggingface dataset:
Evaluation of an Artificial Speech Bandwidth Extension Method in Three Languages (2008)

Quality and intelligibility of narrowband telephone speech can be improved by artificial bandwidth extension (ABE), which extends the speech bandwidth using only information available in the narrowband speech signal. This paper reports a three-language evaluation of an ABE method that has recently been launched in several of Nokia's mobile telephone models. The method extends the speech bandwidth to frequencies above the telephone band by first utilizing spectral folding and then modifying the magnitude spectrum of the extension band with spline curves. The performance of the method was evaluated by formal listening tests in American English, Russian, and Mandarin Chinese. The results of the listening tests indicate that ABE processing improved the subjective quality of coded narrowband speech in all these languages. Differences between bandwidth-extended American English test sentences and their original wideband counterparts were also evaluated using both an objective distance measure that simulates the characteristics of human hearing and a conventional spectral distortion measure. The average objective error was calculated for different categories of speech sounds. The error was found to be smallest in nasals and semivowels and largest in fricative sounds.
The cellular and molecular biology of skin aging. (1994)

The recent discovery of a structural change in the telomeric region of the genome with cellular aging and new insights into DNA damage checkpoint mechanisms offer new opportunities to uncover both the molecular mechanisms regulating cellular aging and possibly to devise new strategies to manipulate these molecular events for therapeutic effect.
Response of the Corneal Epithelium to Krf Excimer Laser Pulses (1981)

The response of the corneal epithelium of Dutch-belted rabbits to 50-nsec pulses of 248-nm KrF excimer laser radiation was studied with slit-lamp biomicroscopy. The corneal epithelium was examined at immediate, 1-, 2- and 24-hr postexposure times. At 24 hr, the observations were made with and without fluorescein staining. The damage endpoint (ED50) was the 50% probability of detecting an opacity or fluorescein uptake. Damage ED50 levels of 59 mJ/cm2 for 2-hr past-exposure and 3 mJ/cm2 for 24-hr postexposure (fluorescein uptake) were measured. In general, the damage response level of the cornea was within 20–100% of those values reported for long duration UV exposures. This indicates only a slight departure from reciprocity.
Molecular cloning of extensive sequences of the in vitro synthesized chicken ovalbumin structural gene (1977)

Double-stranded DNA molecules complementary to ovalbumin chicken messenger RNA were synthesized in vitro and integrated into the E. coli plasmid pCR1 using an oligodG-dc tailing procedure. The resultant hybrid plasmids, amplified by transfection of E. coli, were shown by hybridization and gel electrophoresis to contain extensive DNA sequences of the ovalbumin structural gene.
Refined linkage map of chromosome 7 in the region of the cystic fibrosis gene. (1988)

The genetic map in the region of human chromosome 7 that harbors the gene for cystic fibrosis (CF) has been refined by multilocus linkage studies in an expanded database including a large set of normal families. Six loci known to be linked to CF were examined: MET, an oncogene; COL1A2, collagen, TCRB, T-cell-receptor beta polypeptide; and three arbitrary loci--D7S8, D7S13, and D7S16--defined by probes pJ3.11, pB79a, and p7C22, respectively. The gene order with greatest statistical support is COL1A2-D7S13-D7S16-MET-D7S8-TCRB. Linkage analysis in families segregating for CF suggested that the most likely location of the CF gene on this map is between MET and D7S8.
An 8/9 rate time-varying trellis code for high density magnetic recording (1997)

A simple time-varying trellis code constraint is introduced which achieves 2.2 dB coding gain with the EEPR4 partial response target in additive white Gaussian noise. The capacity of this 'Tribit Mod 2' (TM2) constraint is 0.9163. A block code construction and a practical 8/9 rate block code of length 9 with an RLL k=11 constraint is detailed. Quasi-catastrophic events are described in NRZI space and are shown to be coded out of the 8/9 code. The TM2 code's effective minimum distance including noise coloration effects is analyzed, and shows that coding gain is achieved at high channel densities with the EPR4 partial response target as well as with the EEPR4 and maximum likelihood targets.
走进工厂，近距离接触25nm NAND闪存制造技术 (2010)

目前．限制SSD普及的门槛依然是昂贵的价格和较小的容量，而各大闪存制造厂商也在为SSD的普及．积极地研制新制程技术．以期望带来更具性价比的产品。显然，英特尔和美光的合作，使两家公司在技术和创新上走在了其他公司的前面。
cw Brillouin laser (1976)

The observation of efficient continuous-wave Brillouin laser action in an optical-fiber ring resonator is reported. Internal laser conversion efficiencies of 50% and a Brillouin-shifted output of 20 mW have been achieved.
Regulatory T-cells are essential to promote proper CD4 T-cell priming upon mucosal infection (2016)

Abstract Regulatory T-cells (Tregs) limit autoimmunity and immunopathology using a variety of suppressive mechanisms, but their roles during pathogen-directed immune responses remain unclear. Following Herpes Simplex virus-2 (HSV-2) infection, mice lacking Tregs fail to control viral replication, pointing to a role for Tregs in facilitating productive immune responses. Using adoptive transfer of TCR transgenic CD4 T-cells into Treg-sufficient or Treg-depleted mice prior to HSV-2 infection, we found that Tregs are required for timely accumulation of HSV-2-specific CD4 T-cells within the infected tissues. Further, Tregs are critical for appropriate trafficking of dendritic cells (DCs) from the vaginal mucosa to the dLN, which results in fully effective CD4 T-cell priming, activation, and ultimately migration to the infected tissues. Using CTLA-4 conditional knockout mice, we demonstrate that Tregs impact DC migration through a CTLA-4-mediated mechanism. Together, our data highlight the critical role of Tregs in proper potentiation of adaptive immune responses to microbial infection.
Antipsychotics : treating psychosis, mania and depression (2010)

1. Neurobiology of schizophrenia and mood disorders 2. Multifunctionality of antipsychotics 3. Side effects of antipsychotics: metabolic issues and sedation 4. Individual antipsychotic drugs 5. Schizophrenia pharmacy and switching strategies.
Ganglioside GM3: an acidic membrane component that increases during macrophage-like cell differentiation can induce monocytic differentiation of human myeloid and monocytoid leukemic cell lines HL-60 and U937. (1986)

When human myeloid and monocytoid leukemic cell lines HL-60 and U937, respectively, were treated with an exogenous sialoglycosphingolipid, ganglioside GM3, in serum-free medium, cell growth was markedly inhibited, and their morphological maturation along a monocytic lineage was observed. In addition to a significant increase in phagocytic and nonspecific esterase activities, marked increase of monocyte-specific surface antigens detectable with monoclonal antibodies such as OKM1 and OKM5 was observed in GM3-fed cells. Other sialoglycosphingolipids with the carbohydrate structure belonging to ganglio-series oligosaccharide, ganglioside GM1 and a brain ganglioside mixture, had no effect on the cell differentiation, showing instead stimulatory actions on the growth of these cell lines. We recently demonstrated that the ganglio-series ganglioside GM3 characteristically increased during macrophage-like cell differentiation of these cell lines. The present results indicate that ganglioside molecular species that specifically increase during monocytic cell differentiation of human myeloid and monocytoid leukemic cell lines may play, in turn, an important role in the differentiation-induction of these cell lines along a monocytic cell lineage.
Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine. (1994)

Hypercholesterolemia enhances the adhesiveness of aortic endothelium for monocytes; this effect is attenuated by dietary L-arginine. Conversely, inhibition of NO synthesis enhances monocyte binding. The results suggest that endothelium-derived NO plays an important role in regulating the endothelial adhesiveness for monocytes. Alterations in NO activity may play a critical role in atherogenesis.
Interacting with audio streams for entertainment and communication (2003)

We present a new model of interactive audio for entertainment and communication. A new device called the DJammer and its associated technologies are described. The DJammer introduces the idea of provisioning mobile users to interact cooperatively with digital audio streams. Users can augment the audio in real time and communicate the result in several ways resulting in a new form of multimedia communication across diverse devices and multiple networks. This paper describes the technologies incorporated into the DJammer, and discusses the actual implementation of the prototype DJammer. Future enhancements are also described.
An overview of third-generation wireless personal communications: a European perspective (1998)

An overview of third-generation wireless personal communications is presented, and the challenges to meet its demands are examined. At the ITU level, the third generation is known as IMT-2000. In Europe, the third generation of wireless personal communications is known as UMTS. Special attention has been paid in giving a brief description of the research and development, standardization, and regulatory activities. The UMTS terrestrial radio access (UTRA) concept is presented. The different ACTS projects involved in making UMTS a success are introduced.
Hepatic Steatosis and Normothermic Perfusion—Preliminary Experiments in a Porcine Model (2011)

This study suggests that steatotic livers can be successfully preserved using normothermic preservation for prolonged periods and that normothermic preservation facilitates a reduction in hepatic steatosis. Further studies are now needed including transplantation of steatotic livers after normothermic preservation.
Electromagnetic tracking system for minimal invasive interventions using a C-arm system with CT option: first clinical results (2008)

To ensure precise needle placement in soft tissue of a patient for e.g. biopsies, the intervention is normally carried out image-guided. Whereas there are several imaging modalities such as computed tomography, magnetic resonance tomography, ultrasound, or C-arm X-ray systems with CT-option, navigation systems for such minimally invasive interventions are still quite rare. However, prototypes and also first commercial products of optical and electromagnetic tracking systems demonstrated excellent clinical results. Such systems provide a reduction of control scans, a reduction of intervention time, and an improved needle positioning accuracy specially for deep and double oblique access. Our novel navigation system CAPPA IRAD EMT with electromagnetic tracking for minimally invasive needle applications is connected to a C-arm imaging system with CT-option. The navigation system was investigated in clinical interventions by different physicians and with different clinical applications. First clinical results demonstrated a high accuracy during needle placement and a reduction of control scans.
Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti–IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease (2008)

Interleukin-6 (IL-6) plays pathologic roles in immune-inflammatory diseases such as rheumatoid arthritis (RA) and Castleman disease. By inhibiting IL-6 receptors (IL-6Rs), tocilizumab (a humanized anti-IL-6R antibody) ameliorates the symptoms of these diseases and normalizes acute-phase proteins, including C-reactive protein (CRP). We found that tocilizumab treatment increased serum levels of IL-6 and soluble IL-6R (sIL-6R). To investigate the pathologic significance of these increases, we analyzed the kinetics of serum IL-6 and sIL-6R and the proportion of sIL-6R saturated with tocilizumab after tocilizumab administration in patients with RA and Castleman disease and then compared the results with the CRP values. Serum IL-6 and sIL-6R markedly increased after tocilizumab administration in both RA and Castleman disease. As long as free tocilizumab was detectable, sIL-6R was saturated with tocilizumab and IL-6 signaling was completely inhibited. We concluded that it is likely that sIL-6R increased because its elimination half-life was prolonged by the formation of tocilizumab/sIL-6R immune complex, and that free serum IL-6 increased because IL-6R-mediated consumption of IL-6 was inhibited by the unavailability of tocilizumab-free IL-6R. We also concluded that the increased level of free IL-6 during tocilizumab treatment closely reflects the actual endogenous IL-6 production and true disease activity.
Light-Induced Biocidal Action of Conjugated Polyelectrolytes Supported on Colloids (2008)

A series of water soluble, cationic conjugated polyelectrolytes (CPEs) with backbones based on a poly(phenylene ethynylene) repeat unit structure and tetraakylammonium side groups exhibit a profound light-induced biocidal effect. The present study examines the biocidal activity of the CPEs, correlating this activity with the photophysical properties of the polymers. The photophysical properties of the CPEs are studied in solution, and the results demonstrate that direct excitation produces a triplet excited-state in moderate yield, and the triplet is shown to be effective at sensitizing the production of singlet oxygen. Using the polymers in a format where they are physisorbed or covalently grafted to the surface of colloidal silica particles (5 and 30 microm diameter), we demonstrate that they exhibit light-activated biocidal activity, effectively killing Cobetia marina and Pseudomonas aeruginosa. The light-induced biocidal activity is also correlated with a requirement for oxygen suggesting that interfacial generation of singlet oxygen is the crucial step in the light-induced biocidal activity.
First example of the atom transfer radical polymerisation of an acidic monomer: direct synthesis of methacrylic acid copolymers in aqueous media (1999)

Sodium methacrylate is polymerised directly via atom transfer radical polymerisation (ATRP) in aqueous media using a poly(ethylene oxide)-based macro-initiator; the resulting poly(ethylene oxide-block-sodium methacrylate) copolymers were obtained in good yield and have narrow molecular weight distributions as evidenced by aqueous GPC.
Pharmacokinetic study of metopimazine by oral route in children (2015)

Metopimazine (MPZ) is an antiemetic considered as a currently used drug. In France, it has become the leading antiemetic mediator due to its good tolerance, however, its pharmacokinetics has never previously been studied in children. MPZ was administered by oral route to 8 children with a single dose of 0.33 mg/kg during an endocrine exploration using stimuli well known for its adverse emetic effects. We used biological remnants from sera following an hGH test in order to obtain the MPZ pharmacokinetics. Plasmatic concentrations of MPZ and the active acid metabolite AMPZ, were quantified by HPLC-MS/MS during a 270 min test period. MPZ is quickly absorbed with a median C max of 17.2 ng/mL at one hour and its half-life is 2.18 h. The plasmatic concentrations of AMPZ were higher than MPZ with a median C max of 76.3 ng/mL, a T max to 150 min and its concentration was approximately maintained at 50 ng/mL from 1 to 4 h. The plasmatic concentrations in children are similar to those observed in adults. No adverse effects, nausea or vomiting occurred during the trial. Therefore, these results confirm the MPZ dosage that should be used in children under 15 kg administered as 0.33 mg/kg up to 3 times a day.
DNA sequence analysis by hybridization with oligonucleotide microchips: MALDI mass spectrometry identification of 5mers contiguously stacked to microchip oligonucleotides (2000)

Matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) has been applied to increase the informational output from DNA sequence analysis. It has been used to analyze DNA by hybridization with microarrays of gel-immobilized oligonucleotides extended with stacked 5mers. In model experiments, a 28 nt long DNA fragment was hybridized with 10 immobilized, overlapping 8mers. Then, in a second round of hybridization DNA-8mer duplexes were hybridized with a mixture of 10 5mers. The stability of the 5mer complex with DNA was increased to raise the melting temperature of the duplex by 10-15 degrees C as a result of stacking interaction with 8mers. Contiguous 13 bp duplexes containing an internal break were formed. MALDI MS identified one or, in some cases, two 5mers contiguously stacked to each DNA-8mer duplex formed on the microchip. Incorporating a mass label into 5mers optimized MALDI MS monitoring. This procedure enabled us to reconstitute the sequence of a model DNA fragment and identify polymorphic nucleotides. The application of MALDI MS identification of contiguously stacked 5mers to increase the length of DNA for sequence analysis is discussed.
Extractive Summarization as Text Matching (2020)

This paper creates a paradigm shift with regard to the way we build neural extractive summarization systems. Instead of following the commonly used framework of extracting sentences individually and modeling the relationship between sentences, we formulate the extractive summarization task as a semantic text matching problem, in which a source document and candidate summaries will be (extracted from the original text) matched in a semantic space. Notably, this paradigm shift to semantic matching framework is well-grounded in our comprehensive analysis of the inherent gap between sentence-level and summary-level extractors based on the property of the dataset. Besides, even instantiating the framework with a simple form of a matching model, we have driven the state-of-the-art extractive result on CNN/DailyMail to a new level (44.41 in ROUGE-1). Experiments on the other five datasets also show the effectiveness of the matching framework. We believe the power of this matching-based summarization framework has not been fully exploited. To encourage more instantiations in the future, we have released our codes, processed dataset, as well as generated summaries in https://github.com/maszhongming/MatchSum.
Identification, synthesis, and modifications of simian rotavirus SA11 polypeptides in infected cells (1982)

The synthesis and processing of simian rotavirus SA11 polypeptides was investigated after infection of MA104 cells. [35S]methionine- or 3H-amino acid-labeled cell extracts were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Viral protein synthesis was maximal 3 to 5 h postinfection, and 12 major viral polypeptides were detected. Immunoprecipitation and peptide mapping experiments, demonstrated five viral structural proteins (125,000 daltons [125K], 94K, 88K, 41K, and 38K). Three proteins (53K, 35K, and 34K) were identified as nonstructural by comparison of their partial proteolysis maps with those from polypeptides of similar molecular weight synthesized in vitro from viral RNA transcripts. Assignment as to structural or nonstructural status of two other primary gene products (26K and 20K) remains tentative. Pulse-chase experiments and tunicamycin blockage of glycosylation revealed cotranslational or post-translational modifications (or both) and precursor-product relationships of several of the polypeptides. Tunicamycin inhibition of glycosylation identified a 35.5K polypeptide which was proven to be the precursor to the 38K structural glycoprotein by immunoprecipitation and peptide mapping analyses. Tunicamycin treatment of infected cells also resulted in the disappearance of other glycoprotein species (23K to 29K) and in the concomitant build-up of an unglycosylated 20K polypeptide, suggesting a precursor-product relationship between those polypeptides. Labeling with [3H]glucosamine or [3H]mannose suggested that the rotavirus glycoproteins contained high mannose oligosaccharides. The effects of amino acid analogs on rotavirus polypeptide synthesis and processing were also investigated.
A tale of three next generation sequencing platforms: comparison of Ion torrent, pacific biosciences and illumina MiSeq sequencers (2012)

Next generation sequencing (NGS) technology has revolutionized genomic and genetic research. The pace of change in this area is rapid with three major new sequencing platforms having been released in 2011: Ion Torrent’s PGM, Pacific Biosciences’ RS and the Illumina MiSeq. Here we compare the results obtained with those platforms to the performance of the Illumina HiSeq, the current market leader. In order to compare these platforms, and get sufficient coverage depth to allow meaningful analysis, we have sequenced a set of 4 microbial genomes with mean GC content ranging from 19.3 to 67.7%. Together, these represent a comprehensive range of genome content. Here we report our analysis of that sequence data in terms of coverage distribution, bias, GC distribution, variant detection and accuracy. Sequence generated by Ion Torrent, MiSeq and Pacific Biosciences technologies displays near perfect coverage behaviour on GC-rich, neutral and moderately AT-rich genomes, but a profound bias was observed upon sequencing the extremely AT-rich genome of Plasmodium falciparum on the PGM, resulting in no coverage for approximately 30% of the genome. We analysed the ability to call variants from each platform and found that we could call slightly more variants from Ion Torrent data compared to MiSeq data, but at the expense of a higher false positive rate. Variant calling from Pacific Biosciences data was possible but higher coverage depth was required. Context specific errors were observed in both PGM and MiSeq data, but not in that from the Pacific Biosciences platform. All three fast turnaround sequencers evaluated here were able to generate usable sequence. However there are key differences between the quality of that data and the applications it will support.
Fidelity of human immunodeficiency virus type I reverse transcriptase in copying natural DNA (1989)

Reverse transcriptase from the human immunodeficiency virus type I (HIV-1) was expressed in E. coli and purified to near homogeneity. The enzyme was shown to contain reverse transcriptase, DNA polymerase and ribonuclease H activities. The DNA polymerase activity converted singly-primed phi X174 (+) DNA into the double-stranded form. Two third of the replication product is ligatable to covalently closed circular DNA (RFIV-form DNA) indicating that DNA synthesis by HIV reverse transcriptase can proceed until the enzyme matches the 5'-end of a pre-existing primer molecule. The in vitro accuracy of HIV reverse transcriptase was measured with the phi X174am16 reversion assay to be 1/7,400. Reversion rates for the individual mispairs were determined from pool bias studies to be 1/8,000 for the dGMP:T template mismatch, 1/35,000 for the dGMP:A template mismatch, 1/45,000 for the dAMP:G template mismatch, 1/73,000 for the dCMP:T template mispair, 1/140,000 for the dCMP:A template mispair, and 1/180,000 for the dGMP:G template mismatch. The dTMP:T template mispair was below the detection limit of the assay indicating a reversion rate of less than 1/300,000 for this particular mispair.