gebhart/patrepeval huggingface dataset:
Sulphonamides as Anti-Inflammatory Agents: Old Drugs for New Therapeutic Strategies in Neutrophilic Inflammation? (1995)

1. It is well known that neutrophils act as mediators of tissue injury in a variety of inflammatory diseases. Their histotoxic activity is presently thought to involve proteinases and oxidants, primarily hypochlorous acid (HOCl). This oxidant is also capable of inactivating the specific inhibitor of neutrophil elastase (alpha 1-antitrypsin), thereby favouring digestion of the connective matrix. 2. In the present work, we found that sulphanilamide and some sulphanilamide-related anti-inflammatory drugs such as dapsone, nimesulide and sulphapyridine reduce the availability of HOCl in the extracellular microenvironment of activated neutrophils and prevent the inactivation of alpha 1-antitrypsin by these cells in a dose-dependent manner. The ability of each drug to prevent alpha 1-antitrypsin from inactivation by neutrophils correlates significantly with its capacity to reduce the recovery of HOCl from neutrophils. Five other non-steroidal anti-inflammatory drugs were completely ineffective. 3. Therefore, sulphanilamide-related drugs, i.e. dapsone, nimesulide and sulphapyridine, have the potential to reduce the bioavailability of neutrophil-derived HOCl and, in turn, to favour the alpha 1-antitrypsin-dependent control of neutrophil elastolytic activity. These drugs appear as a well-defined group of agents which are particularly prone to attenuate neutrophil histotoxicity. They can also be viewed as a previously unrecognized starting point for the development of new compounds in order to plan rational therapeutic strategies for controlling tissue injury during neutrophilic inflammation.
Chromized/Siliconized Diffusion Coatings for Iron-Base Alloys by Pack Cementation (1991)

Abstract The codeposition of chromium and silicon into a 2.25Cr-1.0Mo-0.15C steel, Alloy 800, and 304 stainless steel has been achieved using the pack cementation process. The ferritic coating produced on the 2.25Cr-1.0Mo steel was approximately 225 microns (9 mils) thick, whereas the inward diffusion of chromium and silicon produced a two-phase structure of ferrite and austenite for the 304 stainless steel. Chromium and silicon were incorporated into the austenitic solid solution upon diffusion into Alloy 800. Ail of the coatings had approximately 25-35wt% Cr and 24% Si at the surface. Cyclic oxidation testing in air of the coated 2.25Cr-1.0Mo steel (T=700°C) and 304 stainless steel (T = 1035°C) showed a dramatic decrease in the oxidation kinetics compared to the original uncoated alloys. The cyclic oxidation of Alloy 800 was also improved.
VASOPRESSIN INFUSION IMPROVES HEMODYNAMIC PROFILE IN CHILDREN WITH CONGENITAL HEART DISEASE AND REFRACTORY VASODILATORY SHOCK (2005)

Translations: Abstracts from the Fifth International Symposium on Pediatric Cardiac Intensive Care: Oral Presentations
Design of rate-compatible protograph-based LDPC codes with mixed circulants (2010)

We propose a novel design of rate-compatible protograph-based low-density parity-check code families that can cover a wide range of code rates. In contrast to traditional method of lifting, our lifting method use a combination of different circulant matrix sizes for the base protograph and accumulator to increase the number of achievable rates. We apply this method to an existing code family called AR4JA, which can offer variable rates of R = n+1/n+2 by process of extension. The proposed codes namely mixed-circulant rate-compatible protograph code (MCRC-PC) can reduce the rate step within the AR4JA family. We show that the proposed codes can also retain many of the favorable properties of protograph codes such as a fast encoder and decoder implementation. A set of length k=1024 MCRC-PC codes is designed with decoding thresholds obtained from multi-edge type density evolution, and simulation results show that the rate compatible code family can achieve good performance under message passing decoding algorithm.
Antihuman factor VIII C2 domain antibodies in hemophilia A mice recognize a functionally complex continuous spectrum of epitopes dominated by inhibitors of factor VIII activation (2007)

The diversity of factor VIII (fVIII) C2 domain antibody epitopes was investigated by competition enzyme-linked immunosorbent assay (ELISA) using a panel of 56 antibodies. The overlap patterns produced 5 groups of monoclonal antibodies (MAbs), designated A, AB, B, BC, and C, and yielded a set of 18 distinct epitopes. Group-specific loss of antigenicity was associated with mutations at the Met2199/Phe2200 phospholipid binding beta-hairpin (group AB MAbs) and at Lys2227 (group BC MAbs), which allowed orientation of the epitope structure as a continuum that covers one face of the C2 beta-sandwich. MAbs from groups A, AB, and B inhibit the binding of fVIIIa to phospholipid membranes. Group BC was the most common group and displayed the highest specific fVIII inhibitor activities. MAbs in this group are type II inhibitors that inhibit the activation of fVIII by either thrombin or factor Xa and poorly inhibit the binding of fVIII to phospholipid membranes or von Willebrand factor (VWF). Group BC MAbs are epitopically and mechanistically distinct from the extensively studied group C MAb, ESH8. These results reveal the structural and functional complexity of the anti-C2 domain antibody response and indicate that interference with fVIII activation is a major attribute of the inhibitor landscape.
Enhancement of Two‐Dimensional Electron‐Gas Properties by Zn Polar ZnMgO/MgO/ZnO Structure Grown by Radical‐Source Laser Molecular Beam Epitaxy (2015)

A Zn polar ZnMgO/MgO/ZnO structure with low Mg composition Zn 1− x Mg x O layer ( x = 0.05) grown on a‐plane (11–20) sapphire by radical‐source laser molecular beam epitaxy was reported. The insertion of a thin (1 nm) MgO layer between ZnMgO and ZnO layers in the ZnMgO/ZnO 2DEG structures results in an increase of 2DEG sheet density and affects electron mobility slightly. The carrier concentration reached a value as high as 1.1 × 10 13 cm −2 , which was confirmed by C ‐ V measurements. A high Hall mobility of 3090 cm 2 /Vs at 10 K and 332 cm 2 /Vs at RT was observed from Zn 0.95 Mg 0.05 O/MgO/ZnO heterostructure. The choice of the thickness of MgO was discussed. The dependence of carrier sheet density of 2DEG on ZnMgO layer thickness was calculated in theory and the theoretical prediction and experimental results agreed well.
REVIEWS OF BOOKS (1994)

Journal Article REVIEWS OF BOOKS Get access Guglielmo Ebreo of Pesaro: ‘Depratica seu arte tripudii’ (‘On the Practice or Art of Dancing’). Ed. & trans. by Barbara Sparti. Poems trans, by Michael Sullivan. pp. xvi + 269. ( Clarendon Press, Oxford, 1993, £40. ISBN 0-19-816233-2.) D. R. WILSON D. R. WILSON Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume 75, Issue 4, November 1994, Pages 586–587, https://doi.org/10.1093/ml/75.4.586 Published: 01 November 1994
Neurosteroid Analogues. 16. A New Explanation for the Lack of Anesthetic Effects of Δ16-Alphaxalone and Identification of a Δ17(20) Analogue with Potent Anesthetic Activity (2011)

This study addresses the hypothesis that the lack of anesthetic activity for (3α,5α)-3-hydroxypregn-16-ene-11,20-dione (Δ(16)-alphaxalone) is explained by the steroid Δ(16) double bond constraining the steroid 20-carbonyl group to a position that prevents it from favorably interacting with γ-aminobutyric acid type A (GABA(A)) receptors. A series of Δ(16) and Δ(17(20)) analogues of Δ(16)-alphaxalone was prepared to evaluate this hypothesis in binding, electrophysiological, and tadpole anesthesia experiments. The results obtained failed to support the hypothesis. Instead, the results indicate that it is the presence of the C-21 methyl group in Δ(16)-alphaxalone, not the location of the constrained C-20 carbonyl group, that prevents Δ(16)-alphaxalone from interacting strongly with the GABA(A) receptor and having anesthetic activity. Consistent with this conclusion, a Δ(17(20)) analogue of Δ(16)-alphaxalone without a C-21 methyl group was found to be very similar to the anesthetic steroid (3α,5α)-3-hydroxypregnane-11,20-dione (alphaxalone) with regard to time of onset and rate of recovery from anesthesia when administered to mice by tail vein injection.
Smart SoftPhone Device for Networked Audio- Visual QoS/QoE Discovery &amp; Measurement (2008)

Today Multimedia over IP (MoIP) service is provided through the various access networks to Internet, allowing users to get service anytime and anywhere. To control many resources for QoS/QoE guaranteed services over converged networks, developing smart devices and applications applying pervasive network and computing are one of the hot research issues today. The ISO 8402 vocabulary defines quality as the totality of features and characteristics of a product or services that bear on its ability to satisfy stated and implied needs. Quality of Service (QoS) is the collective effect of service performance which determines the degree of satisfaction of the user of the service (from ITU-T E.8001). And then, Quality of Experience (QoE) is a term to allow for subjective as well as objective measures of QoS, performance and all aspects of the interaction (experience) with the service or product (from SLA management handbook). Both QoS and QoE are described very well with networked multimedia application services such as MoIP, IPTV, and mobile IPTV from most recently research Due to the shared nature of current network structures, guaranteeing the QoS/QoE of Internet applica t i o n s f r o m a n e n d -t o -e n d i s s o m e t i m e s difficult and then it has been requested to develop smart devices which have multi-modal functionality for ubiquitous network and computing environment. There are two different aspects, i.e. 'network' and 'multimedia' that are both closely coupled in many critical issues such as QoS, QoE, etc., for MoIP services. An important problem is to provide realtime QoS/QoE-guaranteed multimedia services over packet-based networks. The problem is still unsolved because there are many parameters affecting quality between network and multimedia. In order to solve the problem, a study on QoS/QoE parameters discovery and measurement is necessary. IP networks are on a steep slope of innovation that will make them the long-term carrier of all types of traffic, including multimedia services in the Next Generation Network (NGN) environment today. However, such networks are not designed for QoS/QoE guaranteed realtime multimedia communication because their variable characteristics (e.g. due to bandwidth, packet loss, delay, etc.) lead to a deterioration in voice/video quality. A major challenge in such networks is how to measure voice/video quality accurately and efficiently considering network resources that provide QoS/QoE-guaranteed services. In this chapter, we design smart SoftPhone device for guaranteeing human perceived_QoS/QoE which can discover and measure various network parameters during www.intechopen.com
DNA Methylation in Colorectal cancer—Impact on Screening and Therapy Monitoring Modalities? (2007)

Colorectal cancer (CRC) is a common malignancy. It arises from benign neoplasms and evolves into adenocarcinomas through a stepwise histological progression sequence, proceeding from either adenomas or hyperplastic polyps/serrated adenomas. Genetic alterations have been associated with specific steps in this adenoma-carcinoma sequence and are believed to drive the histological progression of CRC. Recently, epigenetic alterations (especially DNA methylation) have been shown to occur in colon polyps and CRC. The aberrant methylation of genes appears to act together with genetic alterations to drive the initiation and progression of colon polyps to CRC. DNA methylation changes have been recognized as one of the most common molecular alterations in human tumors, including CRC. Because of the ubiquity of DNA methylation changes and the ability to detect methylated DNA in several body fluids (blood, stool), this specifically altered DNA may serve, on the one hand, as a possible new screening marker for CRC and, on the other hand, as a tool for therapy monitoring in patients having had neoplastic disease of the colorectum. As many CRC patients present with advanced disease, early detection seems to be one of the most important approaches to reduce mortality. Therefore, an effective screening test would have substantial clinical benefits. Furthermore, early detection of progression of disease in patients having had CRC permits immediate commencement of specific treatment regimens (e.g. curative resection of liver and lung metastases) and probably longer survival and better quality of life.
Activating Mutations In Fyn Kinase In Peripheral T-Cell Lymphomas (2013)

Abstract Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of aggressive non Hodgkin lymphomas with poor prognosis. Molecular and cytogenetic studies have shown a prominent role for kinase fusion oncogenes, mostly NPM-ALK, in ALK+ anaplastic large cell lymphomas (ALCLs) and ITK-SYK kinase in unspecified PTCLs. To gain further insight on the genetics and pathogenic mechanisms of aggressive PTCLs we performed an integrated mutation analysis using whole exome sequencing (n=12) and RNAseq (n=35) data. This analysis identified 288 candidate coding somatic mutations in 268 genes including known recurrent mutations in the TET2, DNMT3A and IDH2 epigenetic factor genes and pointed to the FYN kinase gene as a new recurrently mutated oncogene in T-cell transformation. The FYN tyrosine kinase is, with LCK, the predominant SRC family kinase found in T lymphocytes and plays an important role in T-cell activation upon T-cell receptor (TCR) stimulation. FYN mutations in PTCL included a FYN L174R mutation detected in one AITL patient sample, a FYN R176C allele recurrently found in two PTCL NOS cases and a FYN Y531H mutation present in a PTCL NOS sample. Notably, each of these alleles are predicted to specifically disrupt the inhibition of FYN kinase activity by the C terminal SRC kinase (CSK). Thus, structure analysis of FYN and FYN mutant proteins predicted that FYN L174R and, most prominently, FYN R176C and FYN Y531H can disrupt the inhibitory interaction of the FYN SH2 domain with the CSK-phosphorylated Y531. Consistently, pull down assays using GST-FYN-SH2 recombinant proteins and biotinylated C-terminal FYN peptides encompassing Y531 showed abrogation of the interaction between FYN-SH2 and P-Y531 in each of these mutants. In agreement with these results, expression of FYN L174R, FYN R176C and FYN Y531H resulted in increased levels of FYN activation. Moreover, CSK expression effectively inhibited wild type FYN, but failed to abrogate FYN L174R, FYN R176C or FYN Y531H activation. In contrast, pharmacologic kinase inhibition with dasatinib, a multikinase inhibitor which blocks ABL1 and SRC kinases, effectively abrogated the activity of FYN L174R, FYN R176C and FYN Y531H mutant proteins and suppressed the growth of cells transformed via expression of activated FYN mutant alleles. Overall these results support an oncogenic role for FYN activating mutations in the pathogenesis of PTCL and support a role for SRC kinase inhibitors for the treatment of this disease. Disclosures: No relevant conflicts of interest to declare.
Stasis: flexible transactional storage (2006)

An increasing range of applications requires robust support for atomic, durable and concurrent transactions. Databases provide the default solution, but force applications to interact via SQL and to forfeit control over data layout and access mechanisms. We argue there is a gap between DBMSs and file systems that limits designers of data-oriented applications.Stasis is a storage framework that incorporates ideas from traditional write-ahead logging algorithms and file systems. It provides applications with flexible control over data structures, data layout, robustness, and performance. Stasis enables the development of unforeseen variants on transactional storage by generalizing write-ahead logging algorithms. Our partial implementation of these ideas already provides specialized (and cleaner) semantics to applications.We evaluate the performance of a traditional transactional storage system based on Stasis, and show that it performs favorably relative to existing systems. We present examples that make use of custom access methods, modified buffer manager semantics, direct log file manipulation, and LSN-free pages. These examples facilitate sophisticated performance optimizations such as zero-copy I/O. These extensions are composable, easy to implement and significantly improve performance.
Purification of two high molecular weight proteases from rabbit reticulocyte lysate. (1987)

We have purified two high molecular weight proteases approximately 400-fold from rabbit reticulocyte lysate. Both enzymes hydrolyze 125I-alpha-casein and 4-methylcoumaryl-7-amide peptides with tyrosine, phenylalanine, or arginine at the P1 position. Both are inhibited by hemin, thiol reagents, chymostatin, and leupeptin. They differ, however, by other criteria. Degradation of 125I-lysozyme-ubiquitin conjugates and succinyl-Leu-Leu-Val-Tyr-4-methylcoumaryl-7-amide by the larger 26 S protease is stimulated by ATP. Based on sedimentation, gel filtration, and nondenaturing polyacrylamide gel electrophoresis, the ATP-dependent protease has a molecular weight of 1,000,000 +/- 100,000 and is a multisubunit complex. The smaller 20 S protease has a molecular weight of 700,000 +/- 20,000 and is composed of 8-10 separate subunits with Mr values between 21,000 and 32,000. It does not require nucleotides for degradation of protein or peptide substrates. This smaller enzyme is similar, if not identical, to the "multicatalytic proteinase complex" first described by Wilk and Orlowski (Wilk, S., and Orlowski, M. (1983) J. Neurochem. 40, 842-849).
SCID repopulating cells derived from unmobilised adult human peripheral blood (2003)

Severe combined immunodeficient (SCID)-repopulating cells (termed SRC) with lymphohaematopoietic differentiation potential reside at an extremely low frequency in unmobilised adult human peripheral blood. Recently, an ex vivo method of increasing the relative numbers of at least four distinct human stem cell classes, that include CD34+ haematopoietic progenitor cells, in mononuclear cells (MNC) obtained from unmobilised adult human peripheral blood has been described. This process is triggered by a monoclonal antibody (mAb) against the human monomorphic region of the beta chain of HLA-DP, DQ and DR (clone CR3/43). Herein, we assess the ability of human male donor-derived MNC, following ex vivo culturing for 3 hr in haematopoietic-conducive conditions (HCC) (3-hr MNC/HCC), to form SRC in female non-obese diabetic/severe combined immunodeficient (NOD/SCID) mice. All 3-hr MNC/HCC-recipient animals exhibited significant levels (> 0.5%) of human cell engraftment in the bone marrow, thymus and spleen when compared to animals receiving MNC cultured in the absence of CR3/43. Phenotypic characterisation of the bone marrow cell populations of engrafted mice demonstrated significant levels of human lymphohaematopoietic cell lineages, comprised of T lymphocytes, monocytes, erythrocytes and megakaryocytes, including platelets. In addition, significant levels of clonogenic human CD34+ cells were also detected by in vitro surrogate assay. The thymi of engrafted animals contained maturating human thymocytes, while the spleen consisted mainly of T lymphocytes. Fluorescence in situ hybridisation (FISH) further identified the presence of human male X and Y chromosomes at engrafted sites, whilst the human origin of the cells was confirmed by a specific PCR assay for the human Cart-1 gene. In conclusion, the conversion of MNC to SRC in response to treatment with CR3/43 for 3 hr could have far-reaching clinical implications especially where time and donor-histocompatibility are limiting factors.
Packet Broadcast Networks&#8212;A Performance Analysis of the R-ALOHA Protocol (1980)

In packet broadcast networks, users are interconnected via a broadcast channel. The key problem is multiple access of the shared broadcast channel. The performance of the R-ALOHA protocol for multiple access is studied in this paper. Two user models with Poisson message arrivals are analyzed; each message consists of a group of packets with a general probability distribution for group size. In the first model, each user handles one message at a time. In the second model, each user has infinite buffering capacity for queueing. Analytic models are developed for characterizing message delay and channel utilization. Bounds on channel throughput are established for two slightly different protocols. Numerical results from both analysis and simulation are presented to illustrate the accuracy of the analytic models as well as performance characteristics of the R-ALOHA protocol.
Effect of novel rinsing material and surfactant treatment on the resist pattern performance (2007)

Surfactant treatments, with SCR101 and EX01, were applied to both line-space and hole patterns in this report. 10% Reduction of line-width roughness and the raise of normalized aspect ratio were observed in line-space patterns after surfactant treatments, compared with those only treated with DI water. From top-view and cross-section images of hole patterns, it was found that bottom scum was eliminated and the contact-edge roughness (CER) was also improved after surfactant treatments. Although 1 to 5% shrinkage of patterns appeared, the depth of focus (DOF) of hole patterns was still increased due to removal of bottom scum. By applying the surfactant treatment, we were able to improve not only line width roughness and collapse margin of line-space patterns, but also CER and DOF of hole patterns.
Abstract 4220: A cell-penetrating nucleolytic lupus autoantibody damages DNA and is toxic to BRCA2-deficient cancer cells (2014)

Abstract Identification of therapeutic agents that are more toxic to malignant cells than normal cells is a key goal in cancer research. Many tumor cells harbor genetic defects that distinguish them from normal cells, and some of these defects have the potential to be exploited in the development of targeted therapies for cancer. Cancer cells with defects in DNA repair are highly susceptible to DNA-damaging agents, but delivery of therapeutic agents into cell nuclei can be challenging. A subset of lupus autoantibodies is associated with nucleolytic activity, and some of these antibodies are capable of nuclear penetration. We hypothesized that such antibodies might be capable of damaging DNA in cell nuclei and therefore have potential as therapeutic agents targeted towards DNA repair-deficient malignancies, such as tumors that are BRCA2-deficient. To test this hypothesis we screened a panel of cell-penetrating lupus autoantibodies for nucleolytic activity, and we identified 5C6 as an antibody of interest. 5C6 catalyzes degradation of single and double-stranded DNA in vitro and induces phospho-H2AX formation in BRCA2-deficient cells. When tested on a matched pair of BRCA2-proficient and deficient cancer cells, 5C6 selectively suppressed the growth of and was significantly more toxic to the BRCA2-deficient cells. These findings demonstrate the potential utility of 5C6 in targeted therapy for DNA repair-deficient malignancies and strengthen the rationale for studies of additional lupus autoantibodies in order to identify the best candidates for development as therapeutic agents. In addition, the toxicity of 5C6 for BRCA2-deficient cells provides further support for the hypothesis that some lupus autoantibodies contribute to the unusual cancer risk profile associated with systemic lupus erythematosus. Citation Format: Philip W. Noble, Melissa R. Young, Richard H. Weisbart, James E. Hansen. A cell-penetrating nucleolytic lupus autoantibody damages DNA and is toxic to BRCA2-deficient cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4220. doi:10.1158/1538-7445.AM2014-4220