gebhart/patrepeval huggingface dataset:
4G, LTE-Advanced Pro and The Road to 5G Ed. 3 (2016)

The upcoming 5G specifications from 3GPP, to be available in 2018, will include LTE-Advanced Pro as well as a new 5G radio-access technology. This practical and very successful book, written by engineers working closely with 3GPP, gives insight into the newest technologies and standards adopted by 3GPP, with detailed explanations of the specific solutions chosen and their implementation in LTE, LTE-Advanced, and LTE-Advanced Pro, as well as providing a detailed description of the path to 5G and the associated underlying technologies. This edition has been thoroughly revised and updated to reflect the large extensions to LTE as introduced in 3GPP Releases 12 and 13 and the role of LTE in the upcoming 5G era. New to this edition includes updated content on: 4G and 5G Radio Access Spectrum for 4G and 5G Machine-Type Communication Device-to-Device Communication License-assisted Access Full-dimension MIMOSmall-cell enhancements, eIMTA, FDD+TDD aggregation, dual connectivity Requirements on and general structure of 5G wireless access, addressing the existing and new usage scenarios for 5GTechnical solutions for the new 5G radio-access technology The authors of this book all work at Ericsson Research and have been deeply involved in 3G and 4G development and standardization. They are leading experts in the field and are today actively contributing to the standardization of 4G and 5G within 3GPP.The leading book on 3GPP specifications for LTE, LTE-Advanced, and LTE-Advanced Pro covering up to and including Release 13, written by Ericsson engineers who are heavily involved in the development of 3GPP specificationsTen new chapters and coverage of all major features introduced with Release 12 and 13Two completely new chapters on 5G wireless access including a detailed description of the key technology components under development by 3GPP
Constitutive Activation of the DNA Damage Signaling Pathway in Acute Myeloid Leukemia with Complex Karyotype: Potential Importance for Checkpoint Targeting Therapy (2009)

Genomic instability in solid tumors participates in the oncogenetic process and is associated with the activation of the DNA damage response pathway. Here, we report the activation of the constitutive DNA damage and checkpoint pathway associated with complex karyotypes in samples from patients with acute myeloid leukemia (AML). We show that antagonizing CHK1 kinase with a small inhibitory compound or by RNA interference strongly reduces the clonogenic properties of high-DNA damage level AML samples, particularly those with complex karyotypes. Moreover, we observe a beneficial effect of CHK1 inhibition in high-DNA damage level AML samples treated with 1-beta-d-arabinofuranosylcytosine. In contrast, CHK1 inhibition has no effect on the clonogenic properties of normal hematopoietic progenitors. All together, our results indicate that CHK1 inhibition may represent an attractive therapeutic opportunity in AML with complex karyotype.
Rapid Infant Weight Gain Predicts Childhood Overweight (2006)

Among this contemporary, multi-ethnic cohort, rapid infant weight gain was associated with increased risk of being overweight at 4 years of age, independently of potential confounders. Identification of the risk factors contributing to rapid weight gain during infancy might improve early recognition and guide strategies for optimal nutrition to prevent the development of childhood overweight.
Combination benefit of treatment with the cytokine inhibitors interleukin-1 receptor antagonist and PEGylated soluble tumor necrosis factor receptor type I in animal models of rheumatoid arthritis (2000)

The results provide preclinical support for the hypothesis that IL-1Ra administered in combination with PEG sTNFRI might provide substantially more clinical benefit to RA patients than either agent alone at blood levels that are currently achievable in patients.
Support vector machine learning for interdependent and structured output spaces (2004)

Learning general functional dependencies is one of the main goals in machine learning. Recent progress in kernel-based methods has focused on designing flexible and powerful input representations. This paper addresses the complementary issue of problems involving complex outputs such as multiple dependent output variables and structured output spaces. We propose to generalize multiclass Support Vector Machine learning in a formulation that involves features extracted jointly from inputs and outputs. The resulting optimization problem is solved efficiently by a cutting plane algorithm that exploits the sparseness and structural decomposition of the problem. We demonstrate the versatility and effectiveness of our method on problems ranging from supervised grammar learning and named-entity recognition, to taxonomic text classification and sequence alignment.
Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1 (2016)

Evidence suggests that specific mutations of isocitrate dehydrogenases 1 and 2 (IDH1/2) are critical for the initiation and maintenance of certain tumor types and that inhibiting these mutant enzymes with small molecules may be therapeutically beneficial. In order to discover mutant allele-selective IDH1 inhibitors with chemical features distinct from existing probes, we screened a collection of small molecules derived from diversity-oriented synthesis. The assay identified compounds that inhibit the IDH1-R132H mutant allele commonly found in glioma. Here, we report the discovery of a potent (IC<sub>50</sub> = 50 nM) series of IDH1-R132H inhibitors having 8-membered ring sulfonamides as exemplified by the compound BRD2879. The inhibitors suppress (<i>R</i>)-2-hydroxyglutarate production in cells without apparent toxicity. Although the solubility and pharmacokinetic properties of the specific inhibitor BRD2879 prevent its use <i>in vivo</i>, the scaffold presents a validated starting point for the synthesis of future IDH1-R132H inhibitors having improved pharmacological properties.
Peripheral Blood Mononuclear Cells (2015)

Numerous cell types are involved in maintenance of the intestinal tissue. However, the main players are cells of the epithelial lining and the immune system. Human peripheral blood mononuclear cells (PBMCs) are used to investigate the effect of food bioactives on various immune cells. These cells are easily isolated from blood of healthy donors or buffy coats (leukocyte concentrates, a by-product from hospital Blood Banks in the manufacturing of red blood cell and thrombocyte concentrates from anti-coagulated whole blood). PBMCs have a different composition, phenotype and activation status than cells found in intestinal tissue. However, this is a useful test system for investigation of immune modulatory effects of food bioactive compounds. Methods for the isolation of PBMCs and how they are used to investigate effects of bioactive components are discussed in this chapter.
TRIM/RBCC, a novel class of ‘single protein RING finger’ E3 ubiquitin ligases (2005)

The TRIM/RBCC proteins are defined by the presence of the tripartite motif composed of a RING domain, one or two B-box motifs and a coiled-coil region. These proteins are involved in a plethora of cellular processes such as apoptosis, cell cycle regulation and viral response. Consistently, their alteration results in many diverse pathological conditions. The highly conserved modular structure of these proteins suggests that a common biochemical function may underlie their assorted cellular roles. Here, we review recent data indicating that some TRIM/RBCC proteins are implicated in ubiquitination and propose that this large protein family represents a novel class of 'single protein RING finger' ubiquitin E3 ligases.
ChemInform Abstract: Ring‐Closing Metathesis and Related Processes in Organic Synthesis (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Percutaneous Stabilization of U-Shaped Sacral Fractures Using Iliosacral Screws: Technique and Early Results (2001)

These sacral fractures are rare and occur after significant spinal axial loading. A paradoxic inlet view of the upper sacrum on the anteroposterior plain pelvic radiograph heralds the diagnosis. Delayed diagnosis is avoided by a high clinical suspicion, early lateral sacral radiographs, and pelvic computed tomography scans. Surgical stabilization may assist in early mobilization of the patient from recumbency and prevents progressive deformity with associated nerve root injury. Percutaneous fixation diminishes potential blood loss and operative times, yet still allows subsequent sacral decompression of the local neural elements using open techniques when necessary. Early percutaneous iliosacral screw fixation is effective treatment for these injuries.
Reactions of hydroxymethylene ketones. Part II. Other routes for the preparation of isoxazoles and pyrazoles (1968)

The reactions of cinnamoylacetaldehydes with acetyl chloride, ammonia, o-phenylenediamine, and semicarbazide have been studied, and the compounds obtained therefrom have been converted into styryl-isoxazoles and -pyrazoles.
Respiratory Syncytial Virus Infection and G and/or SH Protein Expression Contribute to Substance P, Which Mediates Inflammation and Enhanced Pulmonary Disease in BALB/c Mice (2000)

A distinct clinical presentation of respiratory syncytial virus (RSV) infection of humans is bronchiolitis, which has clinical features similar to those of asthma. Substance P (SP), a tachykinin neuropeptide, has been associated with neurogenic inflammation and asthma; therefore, we chose to examine SP-induced inflammation with RSV infection. In this study, we examined the production of pulmonary SP associated with RSV infection of BALB/c mice and the effect of anti-SP F(ab)(2) antibodies on the pulmonary inflammatory response. The peak production of pulmonary SP occurred between days 3 and 5 following primary RSV infection and day 1 after secondary infection. Treatment of RSV-infected mice with anti-SP F(ab)(2) antibodies suggested that SP may alter the natural killer cell response to primary and secondary infection. In mice challenged after formalin-inactivated RSV vaccination, SP appears to markedly enhance pulmonary eosinophilia as well as increase polymorphonuclear cell trafficking to the lung. Based on studies with a strain of RSV that lacks the G and SH genes, the SP response to RSV infection appears to be associated with G and/or SH protein expression. These data suggest that SP may be an important contributor to the inflammatory response to RSV infection and that anti-SP F(ab)(2) antibodies might be used to ameliorate RSV-associated disease.
The First Synthesis of a Thioglycoside Analogue of the Immunostimulant KRN7000 (2008)

The first total synthesis of a thioglycoside analogue of KRN7000, a potential immunostimulant, is described. Two key intermediates are alpha-galactosyl thiol 4 and phytosphingosine derivative 5, which were both prepared from D-galactose.
Increases in Anthropogenic Gadolinium Anomalies and Rare Earth Element Concentrations in San Francisco Bay over a 20 Year Record (2016)

We evaluated both the spatial distribution of gadolinium (Gd) and other rare earth elements (REE) in surface waters collected in a transect of San Francisco Bay (SFB) and their temporal variations within the Bay over two decades. The REE were preconcentrated using the NOBIAS PA-1 resin prior to analysis by high-resolution inductively coupled plasma mass spectrometry. Measurements revealed a temporal increase in the Gd anomaly in SFB from the early 1990s to the present. The highest Gd anomalies were observed in the southern reach of SFB, which is surrounded by several hospitals and research centers that use Gd-based contrast agents for magnetic resonance imaging. Recent increases in that usage presumably contributed to the order of magnitude increase in anthropogenic Gd concentrations in SFB, from 8.27 to 112 pmol kg(-1) over the past two decades, and reach the northeast Pacific coastal waters. These measurements (i) show that "exotic" trace elements used in new high-tech applications, such as Gd, are emerging contaminants in San Francisco Bay and that anthropogenic Gd concentrations increased substantially over a 20 year period; (ii) substantiate proposals that REE may be used as tracers of wastewater discharges and hydrological processes; and (iii) suggest that new public policies and the development of more effective treatment technologies may be necessary to control sources and minimize future contamination by REE that are critical for the development of new technologies, which now overwhelm natural REE anomalies.
Novel determinant of PKC-ε anchoring at cardiac Z-lines (2005)

The Z-line represents a critical link between the transverse tubule network and cytoskeleton of cardiac cells with a role in anchoring structural proteins, ion channels, and signaling molecules. Protein kinase C-epsilon (PKC-epsilon) regulates cardiac excitability, cardioprotection, and growth, possibly as a consequence of translocation to the Z-line/T tubule region. To investigate the mechanism of PKC-epsilon translocation, fragments of its NH2-terminal 144-amino acid variable domain, epsilonV1, were fused with green fluorescent protein and evaluated by quantitative Fourier image analysis of decorated myocytes. Deletion of 23 amino acids from the NH2-terminus of epsilonV1, including an EAVSLKPT motif important for binding to a receptor for activated C kinase (RACK2), reduced but did not abolish Z-line binding. Further deletions of up to 84 amino acids from the NH2-terminus of epsilonV1 also did not prevent Z-line decoration. However, deletions of residues 85-144 from the COOH-terminus strongly reduced Z-line binding. COOH-terminal deletions caused 2.5-fold greater loss of binding energy (deltadeltaG) than did NH2-terminal deletions. Synthetic peptides derived from these regions modulated epsilonV1 binding and cardiac myocyte function, but also revealed considerable heterogeneity within populations of adult cardiac myocytes. The COOH-terminal subdomain important for Z-line anchoring maps to a surface in the epsilonV1 crystal structure that complements the eight-amino acid RACK2 binding site and two previously identified membrane docking motifs. PKC-epsilon anchoring at the cardiac Z-line/T tubule appears to rely on multiple points of contact probably involving protein-lipid and protein-protein interactions.
Gene expression signatures differentiate ovarian/peritoneal serous carcinoma from breast carcinoma in effusions (2010)

Ovarian/primary peritoneal carcinoma and breast carcinoma are the gynaecological cancers that most frequently involve the serosal cavities.With the objective of improving on the limited diagnostic panel currently available for the differential diagnosis of these two malignancies,as well as to define tumour-specific biological targets, we compared their global gene expression patterns. Gene expression profiles of 10 serous ovarian/peritoneal and eight ductal breast carcinoma effusions were analysed using the HumanRef-8 BeadChip from Illumina.Differentially expressed candidate genes were validated using quantitative real-time PCR and immunohistochemistry. Unsupervised hierarchical clustering using all 54,675 genes in the array separated ovarian from breast carcinoma samples. We identified 288 unique probes that were significantly differentially expressed in the two cancers by greater than 3.5-fold, of which 81 and 207 were overexpressed in breast and ovarian/peritoneal carcinoma, respectively. SAM analysis identified 1078 differentially expressed probes with false discovery rate less than 0.05. Genes overexpressed in breast carcinoma included TFF1, TFF3, FOXA1, CA12, GATA3, SDC1, PITX1, TH, EHFD1, EFEMP1, TOB1 and KLF2. Genes overexpressed in ovarian/peritoneal carcinoma included SPON1, RBP1, MFGE8, TM4SF12, MMP7, KLK5/6/7, FOLR1/3,PAX8, APOL2 and NRCAM. The differential expression of 14 genes was validated by quantitative real-time PCR, and differences in 5 gene products were confirmed by immunohistochemistry. Expression profiling distinguishes ovarian/peritoneal carcinoma from breast carcinoma and identifies genes that are differentially expressed in these two tumour types. The molecular signatures unique to these cancers may facilitate their differential diagnosis and may provide a molecular basis for therapeutic target discovery.
Integrin receptors on tumor cells facilitate NK cell‐mediated antibody‐dependent cytotoxicity (2014)

NK cells that mediate ADCC play an important role in tumor-specific immunity. We have examined factors limiting specific lysis of tumor cells by CD16.NK-92 cells induced by CNTO 95LF antibodies recognizing αV integrins that are overexpressed on many tumor cells. Although all tested tumor cells were killed by CD16.NK-92 effectors in the presence of the antibodies, the killing of target cells with a low level of ICAM-1 expression revealed a dramatic decrease in their specific lysis at high antibody concentration, revealing a dose limiting effect. A similar effect was also observed with primary human NK cells. The effect was erased after IFN-γ treatment of tumor cells resulting in upregulation of ICAM-1. Furthermore, killing of the same tumor cells induced by Herceptin antibody was significantly impaired in the presence of CNTO 95Ala-Ala antibody variant that blocks αV integrins but is incapable of binding to CD16. These data suggest that αV integrins on tumor cells could compensate for the loss of ICAM-1 molecules, thereby facilitating ADCC by NK cells. Thus, NK cells could exercise cytolytic activity against ICAM-1 deficient tumor cells in the absence of proinflammatory cytokines, emphasizing the importance of NK cells in tumor-specific immunity at early stages of cancer.
The synthesis of aldose sugars from half-protected dialdehydes using rabbit muscle aldolase (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe synthesis of aldose sugars from half-protected dialdehydes using rabbit muscle aldolaseChristopher W. Borysenko, Andreas Spaltenstein, Julie Ann Straub, and George M. WhitesidesCite this: J. Am. Chem. Soc. 1989, 111, 26, 9275–9276Publication Date (Print):December 1, 1989Publication History Published online1 May 2002Published inissue 1 December 1989https://pubs.acs.org/doi/10.1021/ja00208a046https://doi.org/10.1021/ja00208a046research-articleACS PublicationsRequest reuse permissionsArticle Views410Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Pivotal role of interleukin-8 in the acute respiratory distress syndrome and cerebral reperfusion injury (1997)

Neutrophil recruitment is one of the hallmarks of acute inflammation. A potent neutrophil chemotactic and activating factor, interleukin-8 (IL-8), has been demonstrated to be elevated in body fluids in various human diseases and experimental animal models. Recent investigations on animal disease models using blocking antibodies to IL-8 have revealed the essential involvement of IL-8 in acute inflammation. We previously reported that the administration of a neutralizing antibody against IL-8 prevented the neutrophil infiltration and neutrophil-mediated tissue injury in several animal studies. In addition, we have recently demonstrated that anti-IL-8 treatment is also effective in prevention of two models that are very relevant to clinical situations: cerebral reperfusion injury and endotoxemia-induced acute respiratory distress syndrome-like lung injury. These results further support the hypothesis that IL-8 has a pivotal role and is a novel target for therapeutic intervention in neutrophil-mediated injury.
Renal sympathetic denervation as second‐line therapy in mild resistant hypertension: A pilot study (2012)

As in patients with severe treatment-resistant hypertension, CRD is a safe and effective treatment for patients with milder drug-resistant hypertension.
A strategy for flexible channel assignment in mobile communication systems (1988)

Design concepts and procedure for flexible channel assignment in large-scale mobile radio systems are proposed and discussed. The procedures consist of the analysis process for offered traffic distribution and the transmitter/receiver (TRX) allocation process. The algorithm for the TRX allocation process significantly reduces the total number of TRXs necessary for carrying offered traffic. The number of radio channels necessary for the whole system is derived using these algorithms. In these design procedures, the formidable combinatorics problem of allocation is reduced to a comparatively simple optimization problem. Simple examples applying these algorithms are used for explanation. These algorithms are also effective for the scheduled channel assignment scheme, which is efficient for traffic distributions whose transitions can be definitely estimated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Interactive Broad-Band Dialogue Systems in the Integrated Services Digital Network (ISDN) (1983)

In the integrated services digital network of the future, Which will also have broad-band capacity, it will be possible to offer information services with multimedia presentation (e.g., with support of audiovisual material). For easy use, dialogue structures must be developed which lower the barrier of access for casual users. Offering information in a variety of applications at any place, a technical system consisting of different types of storage devices, operating Systems, and terminals, connected by a narrow- and broad-band switching and transmission system, must be available.
The analysis of buildings (1983)

The Australia ICOMOS 'Guidelines for Conservation Analyses and Plans' have been developed principally out of the experience of work upon buildings rather than upon arhaeological sites or townscapes. Their impact has thus been felt immediately amongst the more enlightened practitioners in this area. Despite these facts it is not yet possible to identify one instance where a brief has been set in the terms of the guidelines, and the analysis has been completed.