gebhart/patrepeval huggingface dataset:
A Pro-Chelator Triggered by Hydrogen Peroxide Inhibits Iron-Promoted Hydroxyl Radical Formation (2006)

The synthesis and structural characterization of a new pro-chelating agent, isonicotinic acid [2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzylidene]-hydrazide (BSIH), are presented. BSIH only weakly interacts with iron unless hydrogen peroxide (H2O2) is present to remove the boronic ester protecting group to reveal a phenol that is a key metal-binding group of tridentate salicylaldehyde isonicotinoyl hydrazone (SIH). BSIH prevents deoxyribose degradation caused by hydroxyl radicals that are generated from H2O2 and redox-active iron by sequestering Fe3+ and preventing iron-promoted hydroxyl radical formation. The rate-determining step for iron sequestration is conversion of BSIH to SIH, followed by rapid Fe3+ complexation. The pro-chelate approach of BSIH represents a promising strategy for chelating a specific pool of detrimental metal ions without disturbing healthy metal ion distribution.
Metabolic fate of pancreas-derived cholesterol esterase in intestine: an in vitro study using Caco-2 cells. (1990)

Bile salt-stimulated cholesterol esterase is synthesized in the pancreatic acinar cells and is released into the intestinal lumen where it catalyzes cholesterol absorption. In the current study, Caco-2 cells were used as an in vitro model to study the interaction between the pancreatic cholesterol esterase with intestinal cells. Results showed that addition of increasing concentrations of cholesterol esterase in the incubation medium increased the uptake of micellar cholesteryl oleate by Caco-2 cells. The cholesterol esterase also increased the cellular uptake of the nonhydrolyzable cholesteryl linoleoyl ether. However, maximum uptake of the cholesteryl ether analog was 50% of that for cholesteryl oleate. The initial interaction of cholesterol esterase with Caco-2 cells was mediated by binding of the protein to a low affinity and high capacity binding site on the cell surface. Cholesterol esterase bound to the cell surface could be internalized via a monensin-sensitive mechanism. The cholesterol esterase taken up by the cells had a short residence time and was either degraded or was rapidly re-secreted from the cells. Chloroquine had no effect on the degradation or re-secretion of cholesterol esterase by Caco-2 cells, indicating that lysosomes were not involved with these processes. The cholesterol esterase taken up by the cells was not available to mediate further cholesterol uptake. These results indicated that the bile salt-stimulated cholesterol esterase secreted from pancreas could facilitate intestinal lipid absorption only transiently. The data suggest that the regulation of cholesterol esterase synthesis and secretion by the pancreas may be important for regulation of cholesterol absorption.
S/W based IF signal simulator prototyping for L1 C/A, L2C, and E1(B&#x00026;C) (2007)

GNSS Digitized IF Signal Simulator (GDISS) is being developed by ETRI as a part of development of software-based Test & Evaluation Facility which will provide test and evaluation environment for various software level application and navigation algorithm in GNSS. GDISS will provide digitized IF data of GPS and Galileo signals. In this paper, GDISS prototype for L1, L2C, and E1(B&C) is developed and verified. The proposed prototype has good modularity and flexibility to add conveniently various modelings like ionospheric model, tropospheric model, multipath model, satellite clock model, etc. It will be verified by the commercial S/W receiver, Nordnav, and the S/W receiver implemented by CNU(Chungnam National University).
Capacitive Power Transfer for Rotor Field Current in Synchronous Machines (2012)

Permanent magnet (PM) synchronous machines are utilized in a wide variety of applications due to their many desirable characteristics, including high torque density capability and high efficiency. In the near future, however, the demand for the PM rare earth materials is projected to exceed world production. As a result, electric machines that do not rely on rare earth materials, such as wound field synchronous machines (WFSMs), are receiving renewed attention for use in traction and wind energy applications. However, WFSMs require a current delivery mechanism to the rotor such as mechanical slip rings whose components require periodic replacement and generate adverse debris within the machine enclosure. Rotary transformers may replace slip rings but also introduce rotor speed dependences and magnetic coupling difficulties. This paper proposes a capacitive noncontact power transfer technique to eliminate the need for mechanical slip rings while also avoiding the pitfalls of rotating transformer technologies. The capacitive power transfer system is compared to traditional rotor power coupling techniques and its performance is validated with experimental results.
The mucosal addressin cell adhesion molecule antibody PF-00547,659 in ulcerative colitis: a randomised study (2011)

The favourable short-term safety profile and preliminary efficacy findings for PF-00547,659 in this first-in-human study pave the way for further investigation in larger trials, to establish the role of PF-00547,659 in ulcerative colitis treatment. Trial Register No: NCT00928681.
Antioxidants Inhibit ATP-Sensitive Potassium Channels in Cerebral Arterioles (1998)

The findings show that antioxidants block ATP-sensitive potassium channels in cerebral arterioles. This appears to be the mechanism by which antioxidants inhibit the dilation from hydrogen peroxide and peroxynitrite and not through scavenging of a common intermediate, ie, hydroxyl radical. The differences between effectiveness in inhibiting dilation from hydrogen peroxide and peroxynitrite by various antioxidants suggest that hydrogen peroxide and peroxynitrite act at two different sites, one in a water-soluble environment and the other in a lipid-soluble environment.
Heat‐Shock Protein 60: Implications for Pathogenesis of and Protection against Bacterial Infections (1991)

In this review we have focused on antigenic features of hsp 60 related to: its ubiquitous distribution in the biosphere; its extraordinary homology among various bacteria; its high conservation from prokaryotic to eukaryotic cells; and its abundant expression under stress situations occurring during infection. These unique features make hsp 60 an excellent candidate antigen relevant to protection and pathogenesis of bacterial infections and, perhaps in a broader sense, to surveillance and autoimmunity. We will briefly discuss these possibilities in the following. Acquired resistance. If we assume that bacterial organisms contain some thousand different proteins which all represent potential antigens, the frequency of T cells with specificity for mycobacterial hsp 60 appears surprisingly high. Although, during the course of infection, high levels of hsp may be induced in bacteria, mere abundance appears to be an important though insufficient explanation. In addition, constant boosting by similar hsp 60 cognates from various microbes with which humans come into contact may contribute to dominance. This could easily explain the occurrence of hsp 60-specific T cells in healthy individuals with no clinical history of mycobacterial infections. Involvement of more sophisticated mechanisms, such as the affinity of hsp to other proteins, cannot be excluded (Flynn et al. 1989). Yet dominance does not necessarily mean protection and definite proof that hsp are protective antigens is lacking. Perhaps the immune response against epitopes shared by various mycobacterial pathogens represents a first line of defence preceding a more specific immune response. Such broadly reactive antigens would not qualify as prime candidates for vaccine design. Immunesurveillance. T cells with specificity for epitopes shared by bacterial and human hsp 60 are readily demonstrable and stressed host cells are recognized by hsp 60-specific T cells. Such T lymphocytes are endowed with the capacity to identify host cells stressed by a variety of assaults such as inflammation, infection, trauma, or transformation. Although it has been claimed that hsp-reactive gamma/delta T cells are particularly destined for such surveillance functions (Born et al. 1990, Asarnow et al. 1988), alpha/beta T cells could also participate. Pathogenesis. The mechanisms causing pathogenesis should be similar to those underlying protection and surveillance. In the former case bacterial hsp would be responsible for both induction of immunity and expression of pathogenic reactions; in the latter case an immune response stimulated by conserved regions of bacterial hsp 60 would be converted against a host-derived cognate.(ABSTRACT TRUNCATED AT 400 WORDS)
A 'Regularly Irregular' tachycardia: what is the diagnosis? (2008)

We report the case of a 46-year-old female presented to the emergency room with sustained palpitations. Her ECG showed a narrow QRS regularly irregular tachycardia. This tachycardia was immediately terminated by a single dose of adenosine, and sinus rhythm was restored. Diagnosis of atrial tachycardia, orthodromic reciprocating tachycardia, and atrial nodal reentrant tachycardia (AVNRT) are discussed. An electrophysiological study was performed for further evaluation, and our final hypothesis was AVNRT with triple nodal pathways. A single application of radiofrequency energy in the posterior septum near the coronary sinus ostium effectively eliminated the tachycardia.
Long-term Angiotensin-Converting Enzyme Inhibition With Fosinopril Improves Depressed Responsiveness to Ca 2+ in Myocytes From Aortic-Banded Rats (1996)

Long-term ACE inhibition improves responsiveness to Ca2+ in the presence of normalization of maximal Ca(2+)-activated force in aortic-banded rats subjected to persistent pressure overload. This may contribute to the favorable effects whereby ACE inhibition modifies the transition from compensated hypertrophy to failure.
Molecular cloning and expression of a cDNA encoding an apoptotic endonuclease DNase γ (1998)

An endonuclease named DNase gamma has been purified from the nuclei of apoptotic rat thymocytes [Shiokawa, Ohyama, Yamada and Tanuma (1997) Biochem. J. 326, 675-681]. Here we report the molecular cloning of a cDNA encoding a 35 kDa precursor protein for rat DNase gamma. A 1.6 kb mRNA coding for the DNase gamma precursor is detected at high levels in spleen, lymph nodes, thymus and liver. By using reverse transcriptase-mediated PCR, expression of DNase gamma mRNA is observed in kidney and testis but not in brain or heart. Analysis of recombinant DNase gamma reveals that full-length DNase gamma, including the N-terminal precursor, is an inactive proenzyme. The mature form of recombinant DNase gamma, from which the N-terminal precursor has been removed, has the same properties as purified DNase gamma: requirement for divalent cations, dependence on pH, sensitivity to Zn2+, and cleavage of chromosome DNA to nucleosomal units. In HeLa S3 cells stably transfected with the DNase gamma cDNA, exogenously introduced DNase gamma is activated by apoptotic stimuli; enhancement of DNA fragmentation, chromatin condensation and nuclear collapse are observed. These findings provide evidence for the involvement of DNase gamma in DNA fragmentation and nuclear structural changes during apoptosis.
Identification and preliminary characterization of a protein motif related to the zinc finger. (1993)

We have identified a protein motif, related to the zinc finger, which defines a newly discovered family of proteins. The motif was found in the sequence of the human RING1 gene, which is proximal to the major histocompatibility complex region on chromosome six. We propose naming this motif the "RING finger" and it is found in 27 proteins, all of which have putative DNA binding functions. We have synthesized a peptide corresponding to the RING1 motif and examined a number of properties, including metal and DNA binding. We provide evidence to support the suggestion that the RING finger motif is the DNA binding domain of this newly defined family of proteins.
Learning Spatiotemporal Features with 3D Convolutional Networks (2015)

We propose a simple, yet effective approach for spatiotemporal feature learning using deep 3-dimensional convolutional networks (3D ConvNets) trained on a large scale supervised video dataset. Our findings are three-fold: 1) 3D ConvNets are more suitable for spatiotemporal feature learning compared to 2D ConvNets, 2) A homogeneous architecture with small 3x3x3 convolution kernels in all layers is among the best performing architectures for 3D ConvNets, and 3) Our learned features, namely C3D (Convolutional 3D), with a simple linear classifier outperform state-of-the-art methods on 4 different benchmarks and are comparable with current best methods on the other 2 benchmarks. In addition, the features are compact: achieving 52.8% accuracy on UCF101 dataset with only 10 dimensions and also very efficient to compute due to the fast inference of ConvNets. Finally, they are conceptually very simple and easy to train and use.
Exploring the similarity space (1998)

Ranked queries are used to locate relevant documents in text databases. In a ranked query a list of terms is specified, then the documents that most closely match the query are returned---in decreasing order of similarity---as answers. Crucial to the efficacy of ranked querying is the use of a similarity heuristic, a mechanism that assigns a numeric score indicating how closely a document and the query match. In this note we explore and categorise a range of similarity heuristics described in the literature. We have implemented all of these measures in a structured way, and have carried out retrieval experiments with a substantial subset of these measures.Our purpose with this work is threefold: first, in enumerating the various measures in an orthogonal framework we make it straightforward for other researchers to describe and discuss similarity measures; second, by experimenting with a wide range of the measures, we hope to observe which features yield good retrieval behaviour in a variety of retrieval environments; and third, by describing our results so far, to gather feedback on the issues we have uncovered. We demonstrate that it is surprisingly difficult to identify which techniques work best, and comment on the experimental methodology required to support any claims as to the superiority of one method over another.
Reduced CRYL1 expression in hepatocellular carcinoma confers cell growth advantages and correlates with adverse patient prognosis (2009)

Homozygous deletion screening has been widely utilized to define tumour suppressor genes (TSGs) in cancers. Although these biallelic deletions are infrequent, their identification has facilitated the discovery of many important TSGs. We have systematically examined the genome of hepatocellular carcinoma (HCC), a highly malignant tumour that is rapidly fatal, for the presence of homozygous deletions. Array-CGH analysis on early passage of HCC cultures and cell lines led us to identify six homozygous deleted (HD) regions. A high concordance between array-CGH and expression of HD genes was demonstrated, where crystallin Lambda1 (CRYL1; located on chromosome 13q12.11) displayed the most frequent down-regulation. We found that reduced mRNA expression of CRYL1 was common in HCC tumours when compared with their adjacent non-tumoural liver (p = 0.0097). Significant associations could also be drawn between repressed CRYL1 and advanced tumour staging, increased tumour size, and shorter disease-free survival of patients (p < 0.037). Moreover, homozygous deletions on CRYL1 could be detected in 36% of HCC cases, where recurrent HDs were identified on exons 1, 5, and 8. Examination of other causal events suggested histone deacetylation and promoter hypermethylation to be likely inactivating mechanisms as well. Re-expression of CRYL1 in the SK-Hep1 cell line, where biallelic loss of CRYL1 was found, induced profound inhibition of cellular proliferation and cell growth (p < 0.0015). By Annexin V staining, CRYL1 restoration readily increased pro-apoptotic cells with an induction of PARP cleavage. Flow cytometry further revealed that CRYL1 could prolong the G(2)-M phase, possibly through interruption of the Cdc2/cyclin B pathway. Given that regional chromosome 13q12-q14 loss is a causal genomic event in HCC tumourigenesis, our finding may have implications for identifying a novel TSG CRYL1 within this important locus.
High heparanase activity in multiple myeloma is associated with elevated microvessel density. (2003)

Heparanase is an enzyme that cleaves heparan sulfate chains of proteoglycans, and its expression has been associated with increased growth, metastasis, and angiogenesis of some tumors. Because myeloma tumor cells express high levels of the syndecan-1 heparan sulfate proteoglycan and because these tumors grow as highly vascularized aggregates within the bone marrow, we analyzed the activity, expression, and function of heparanase in myeloma patients. Analysis of heparanase activity in the plasma isolated from bone marrow biopsies of 100 patients reveals 86 positive for heparanase activity and 14 negative. The bone marrow samples can be further divided into three categories of heparanase activity, high activity (42 patients), low activity (44 patients), and negative (14 patients). In contrast to the bone marrow plasma, levels of heparanase activity in peripheral blood plasma of 29 myeloma patients were either negative or low, suggesting that in multiple myeloma, heparanase functions in the local microenvironment of the bone marrow and its activity is not significantly elevated systemically. Immunohistochemistry reveals that patients with high levels of heparanase activity often have tumor cells with intense staining for the enzyme. Interestingly, a marked heterogeneity among tumor cells was noted, with clusters of heavily stained cells surrounded by cells with weak or negative staining for heparanase. Analysis of microvessel density reveals a strikingly higher concentration of vessels in patients with high heparanase activity (78.96 vessels/mm(2)) as compared with patients negative for heparanase activity (25.03 vessels/mm(2)). When human myeloma cells transfected with the cDNA for heparanase are implanted in severe combined immunodeficient (SCID) mice, the resulting tumors exhibited a significantly higher microvessel density than did tumors established with control cells. Thus, expression of heparanase appears to play a direct role in enhancing microvessel density in these myeloma tumors. Because heparanase is known to stimulate angiogenesis, and because high microvessel density is associated with poor prognosis in myeloma, we conclude that heparanase expression likely plays an important role in regulating the growth and progression of myeloma, and that therapies designed to block heparanase activity may aid in controlling this cancer.
A statistical analysis of hair breakage. II. Repeated grooming experiments. (2011)

The objective of this work was to introduce the idea of analyzing data from repeated brushing and combing experiments on hair in accordance with standard fatigue testing approaches. In mechanical testing terms, the brushing and combing of hair represents a fatiguing process wherein individual strands experience repeated exposure to an external stimulus. Therefore, in accordance with fatiguing principles, one expects a gradual propagation of flaws within individual fibers until, ultimately, catastrophic failure (breakage) results. A previous paper in this series described the modeling of single-fiber fatigue data using the Weibull approach, and, in so doing, introduced the idea of treating fiber breakage as a statistical variable. Here, a grouped Weibull methodology was used to analyze breakage data from repeated brushing and combing experiments. At a top level, the generation of the two Weibull parameters provides a means of characterizing these experiments. However, the real strength of the approach involves the ability to generate survival probability plots that provide predictions as to the likelihood of fiber breakage under different conditions. Therefore, assuming laboratory experiments are a reasonable representation of real-life conditions, it becomes possible to predict breakage rates on actual heads as a function of different habits and practices. It is also shown how the two Weibull parameters, together with information about the number of fibers in the test tresses, allow for the modeling of repeated brushing and combing tests and allow anyone to re-create the experimental outcome for comparison to their own experiences. These principles have been demonstrated using experiments that compare breakage in virgin and chemically damaged hair, while also showing how conditioning treatments provide considerable retardation.
Rapid Charcoal Assay for Intrinsic Factor (IF), Gastric Juice Unsaturated B12 Binding Capacity, Antibody to IF, and Serum Unsaturated B12 Binding Capacity (1965)

Abstract The principle of the dialysis assays for intrinsic factor (IF) and antibody to IF was integrated with the demonstration that protein-coated charcoal adsorbs only free and not bound B12, in a single rapid method for 4 separate assays: (1) assay of IF, (2) assay of gastric juice unsaturated B12 binding capacity, (3) assay of serum antibodies to IF and (4) assay of serum unsaturated B12 binding capacity. The method is sensitive, accurate, reproducible, and can easily be completed within an hour. The simplicity and ready availability of reagents and equipment lends itself to ready adoption in any clinical laboratory using radioisotopes. The charcoal particle is considered as a solid microsponge, and its coat of albumin, other protein, carbohydrate, or other large molecule as a molecular sieve surrounding the sponge. The whole constitutes a system of "instant dialysis," with a wide range of applications in the separation of large from small molecules.
Normal Variants and Pitfalls in CT of the Lumbar Spine (1993)

CT is used widely for evaluation of the lumbar spine for the diagnosis of disc disease and spinal stenosis. However, as with many imaging modalities, imaging pitfalls, benign changes, and normal variants are encountered. These variants and pitfalls usually have characteristic appearances which allow them to be differentiated from pathologic entities, thus avoiding additional work-up expense and, in some cases, unnecessary biopsies.
S 32. Aminoalkyl tertiary carbinols and derived products. Part I. 3-Amino-1 : 1-diphenylpropan-1-ols (1949)

The first page of this article is displayed as the abstract.
Symmetric Nonnegative Matrix Factorization: Algorithms and Applications to Probabilistic Clustering (2011)

Nonnegative matrix factorization (NMF) is an unsupervised learning method useful in various applications including image processing and semantic analysis of documents. This paper focuses on symmetric NMF (SNMF), which is a special case of NMF decomposition. Three parallel multiplicative update algorithms using level 3 basic linear algebra subprograms directly are developed for this problem. First, by minimizing the Euclidean distance, a multiplicative update algorithm is proposed, and its convergence under mild conditions is proved. Based on it, we further propose another two fast parallel methods: α-SNMF and β -SNMF algorithms. All of them are easy to implement. These algorithms are applied to probabilistic clustering. We demonstrate their effectiveness for facial image clustering, document categorization, and pattern clustering in gene expression.