gebhart/patrepeval huggingface dataset:
Wide sternal retraction may impede internal mammary artery graft flow and reduce myocardial function during off-pump coronary artery bypass grafting: presentation of two cases (2012)

The internal mammary artery (IMA) is routinely used for grafting of the left anterior descending coronary artery (LAD), providing good flow to the anterior left ventricle (LV) wall. Impeded IMA-to-LAD flow may result in myocardial ischaemia and haemodynamic deterioration. From a study population, we describe two incidents where myocardial ischaemia was observed during off-pump coronary artery bypass surgery (CABG), with a confirmed reduction in the IMA-to-LAD flow in one patient. In patient no. 1, normal IMA flow was assessed by transit-time flow measurement after a complete IMA-to-LAD anastomosis. The anterior LV wall thickening was monitored continuously by epicardial ultrasonic transducers. Normal wall thickening was confirmed after IMA grafting. During a wide sternal opening for circumflex grafting the anterior wall motion displayed an ischaemic pattern, with reduced systolic and increased post-systolic wall thickening. IMA flow was reduced simultaneously. When easing the sternal opening, IMA flow normalized, as did the motion pattern in the anterior LV wall. In patient no. 2, similar changes in wall thickening occurred during a wide sternal opening after IMA-to-LAD grafting. When easing the retractor, the wall thickening normalized. It is important for the surgeon to be aware of this possible cause of myocardial ischaemia, with a risk of subsequent haemodynamic deterioration. This may not only be of great importance during off-pump CABG, but can also be significant for successful weaning from the cardiopulmonary bypass machine.
What Have 25 Years of Performance Data Taught Us About Private Equity Real Estate? (2015)

Executive SummaryNCREIF has published performance data covering a 25-year historical period for institutional investments following core, value-add, and opportunistic strategies in private equity real estate assets. In this paper, I summarize salient observations regarding capital appreciation, income, fees and expenses, the income share of total return, the effects of cash reserves and leverage, net total returns, systematic risk, and risk-adjusted performance during five informative market periods: two severe real estate market downturns, one complete real estate bull market, and two incomplete bull market periods. The available data challenge several points of conventional wisdom regarding private equity real estate returns.
High-affinity Binding of Epidermal Growth Factor (EGF) to EGF Receptor Is Disrupted by Overexpression of Mutant Dynamin (K44A) (1998)

Activation of the epidermal growth factor receptor (EGFR) kinase was analyzed in cells conditionally defective for clathrin-dependent endocytosis by overexpression of mutant dynamin (K44A). EGF-induced autophosphorylation of the EGFR on ice was strongly reduced in cells overexpressing mutant dynamin, and consistently, binding analyses showed that high-affinity EGFRs were lost. In the absence of mutant dynamin the cells displayed both high- and low-affinity EGFR. At 4 degreesC EGF-EGFR localized mainly outside coated pits regardless of expression of mutant dynamin. However, also low-affinity EGFR efficiently moved to coated pits upon incubating cells at 37 degreesC. Thus, expression of mutant dynamin disrupts high-affinity binding of EGF, but not ligand-induced recruitment of EGFR to clathrin-coated pits.
A magnifier tool for video data (1992)

We describe an interface prototype, the Hierarchical Video Magnifier, which allows users to work with a video source at fine-levels of detail while maintaining an awareness of temporal context. The technique allows the user to recursively magnify the temporal resolution of a video source while preserving the levels of magnification in a spatial hierarchy. We discuss how the ability to inspect and manipulate hierarchical views of temporal magnification affords a powerful tool for navigating, analyzing and editing video streams.
Peritoneal Fluid lnterleukin‐1β and Tumor Necrosis Factor in Patients With Benign Gynecologic Disease (1991)

The levels of interleukin 1 beta (IL-1 beta) and tumor necrosis factor (TNF) in peritoneal fluid (PF-IL-1 beta and PF-TNF) and production of IL-1 beta and TNF by peritoneal macrophages were determined in patients with benign gynecologic disease. The level of PF-IL-1 beta was elevated in the acute pelvic inflammatory disease (PID) and stages I and II endometriosis (E I/II) groups compared with the normal pelvis group, but not in the myoma of the uterus, ovarian cyst, and postinflammatory pelvic adhesion groups. The level of PF-TNF was elevated in the PID, EI/II and stages III and IV endometriosis (EIII/IV) groups. There was no correlation between the levels of PF-IL-1 beta and PF-TNF. Neither the level of PF-IL-1 beta nor that of PF-TNF was correlated with the concentration of peritoneal macrophages. Peritoneal macrophages produced IL-1 beta and TNF in vitro in the absence of stimulants. The levels of PF-IL-1 beta and PF-TNF are presumably linked to the activation of peritoneal macrophages.
Cost of Vaccine Administration Among Pediatric Practices (2009)

This study shows that the variable costs of vaccine administration exceeded reimbursement from some insurers and health plans.
Vapor Heat Research Unit for Insect Quarantine Treatments (1990)

A vapor heat facility was designed and constructed for use in research on heating fruits for insect quarantine treatments. Air was heated to temperatures between 40 and 50°C by direct addition of steam at atmospheric pressure, resulting in relative humidities near 100%. This conditioned air was circulated directly through spaces between fruits by making the fruit load an integral part of the airflow path. With this method, fruits were heated to temperatures lethal to fruit fly eggs or larvae in 3-4 h compared with previous vapor heat treatment periods of up to 14 h.
Interventions to Reduce Harm from Smoking with Families in Infancy and Early Childhood: A Systematic Review (2015)

Exposure to adult smoking can have deleterious effects on children. Interventions that assist families with smoking cessation/reduction and environmental tobacco smoke (ETS) avoidance can improve child health outcomes and reduce the risk of smoking initiation. The purpose of this review was to describe the state of the science of interventions with families to promote smoke-free home environments for infants and young children, including parent smoking reduction and cessation interventions, ETS reduction, and anti-smoking socialisation interventions, using the socio-ecological framework as a guide. A systematic review of peer-reviewed articles identified from journal databases from 2000 to 2014 was undertaken. Of 921 articles identified, 28 were included in the review. Considerable heterogeneity characterised target populations, intervention types, complexity and intensity, precluding meta-analysis. Few studies used socio-ecological approaches, such as family theories or concepts. Studies in early parenthood (child age newborn to one year) tended to focus on parent smoking cessation, where studies of families with children aged 1-5 years were more likely to target household SHSe reduction. Results suggest that interventions for reduction in ETS may be more successful than for smoking cessation and relapse prevention in families of children aged less than 5 years. There is a need for a range of interventions to support families in creating a smoke free home environment that are both tailored and targeted to specific populations. Interventions that target the social and psychodynamics of the family should be considered further, particularly in reaching vulnerable populations. Consideration is also required for approaches to interventions that may further stigmatise families containing smokers. Further research is required to identify successful elements of interventions and the contexts in which they are most effective.
Knowledge-free induction of morphology using latent semantic analysis (2000)

Morphology induction is a subproblem of important tasks like automatic learning of machine-readable dictionaries and grammar induction. Previous morphology induction approaches have relied solely on statistics of hypothesized stems and affixes to choose which affixes to consider legitimate. Relying on stem-and-affix statistics rather than semantic knowledge leads to a number of problems, such as the inappropriate use of valid affixes ("ally" stemming to "all"). We introduce a semantic-based algorithm for learning morphology which only proposes affixes when the stem and stem-plus-affix are sufficiently similar semantically. We implement our approach using Latent Semantic Analysis and show that our semantics-only approach provides morphology induction results that rival a current state-of-the-art system.
From Straight Lines to Deconvolution: The Evolution of the State of the Art in Well Test Analysis (2006)

Abstract Well test analysis has been used for many years to assess well condition and obtain reservoir parameters. Early interpretation methods (using straight-lines or log-log pressure plots) were limited to the estimation of well performance. With the introduction of pressure derivative analysis in 1983 and the development of complex interpretation models that are able to account for detailed geological features, well test analysis has become a very powerful tool for reservoir characterization. A new milestone has been reached recently with the introduction of deconvolution. Deconvolution is a process which converts pressure data at variable rate into a single drawdown at constant rate, thus making more data available for interpretation than in the original data set, where only periods at constant rate can be analyzed. Consequently, it is possible to see boundaries in deconvolved data, a considerable advantage compared to conventional analysis, where boundaries are often not seen and must be inferred. This has a significant impact on the ability to certify reserves. The paper reviews the evolution of analysis techniques over the last half-century and shows how improvements have come in a series of step changes twenty years apart. Each one has increased the ability to discriminate between potential interpretation models and to verify the consistency of the analysis. This has increasing drastically the amount of information that can be extracted from well test data and more importantly, the confidence in that information.
The real-time rendering of subdivision surfaces using hardware tessellation (2015)

Abstract In the last decade, computer-generated images have become a vital and integral part of our everyday lives. The quality of these images depends considerably on the geometric representation of the underlying virtual 3D environments. Subdivision surfaces, one such representation, have been found to be very useful due to their unique geometric properties. These properties led to the adaptation of subdivision surfaces as a movie industry standard for modeling 3D geometry, making subdivision surfaces indispensable in today's film productions. However, despite the high surface quality of subdivision surfaces, the complexity of underlying calculations requires a significant computational budget. In this thesis, we address this problem and propose novel algorithms to accelerate the evaluation of subdivision surfaces by several orders of magnitude. This enables the rendering of high-quality movie content on commercially available desktop computers within only a few milliseconds, opening up the possibility of using subdivision surfaces in real-time applications (e. g., video games). The results of this work have been made publicly available in Pixar's open source initiative OpenSubdiv , which is used in many industry applications (e. g., Maya, a modeling software by the industry leader Autodesk). Our algorithms can also be found in video games such as Activision's best seller Call of Duty: Ghosts , where we now can enjoy the surface quality of movies.
Optical properties of pseudomorphic Si/sub 1-x/Ge/sub x/ for Si-based waveguides at the λ=1300-nm and 1550-nm telecommunications wavelength bands (1998)

The index of refraction for pseudomorphic Si/sub 1-x/Ge/sub x/ layers grown on Si has been measured at wavelengths /spl lambda/=1310 mn and /spl lambda/=1550 nm. The refractive index values were obtained from waveguide mode profile measurements on a series of Si-Si/sub 1-x/Ge/sub x/-Si waveguides with Ge/sub x/ concentrations between x=0.01 and x=0.1. The index of refraction, n, is significantly larger for light polarized parallel to the growth direction than for light polarized in the plane of the epilayer. This birefringence is consistent with the anisotropic index change predicted using photoelastic theory, given the biaxial strain present in the pseudomorphic Si/sub 1-x/Ge/sub x/ layers. At all wavelengths and polarizations, n varies linearly with the Ge concentration. The pseudomorphic Si/sub 1-x/Ge/sub x/ waveguides layer are stable against lattice relaxation during short anneals at 950/spl deg/C, but exhibit partial relaxation after annealing at 1200/spl deg/C.
Evaluation, by a Statistically Designed Experiment, of an Experimental Grade of Microcrystalline Cellulose, Avicel 955, as a Technology To Aid the Production of Pellets with High Drug Loading (1996)

A statistically designed experiment has been undertaken to evaluate an experimental grade of microcrystalline cellulose (Avicel 955) as a technology to aid the production of pellets by extrusion spheronization of formulations with high drug load. An attempt has been made to relate the properties of the drugs to the ability to produce spherical pellets which have a narrow size distribution and are round, as assessed by a 2-dimensional shape factor by the process of extrusion/spheronization. Twenty drugs were tested at a level of 80%, and in all cases pellets could be produced. In some cases in terms of either size distribution or shape they were not of the highest quality. Nevertheless, a best level of water was identified for each drug. Principal component analysis did allow structuring of the data characterizing the process and the pellets, identifying a relationship between the water content and the steady state extrusion force as one component with the median pellet size and its interquartile range as the other. When multivariate analysis was used with the whole data set, it was not possible to relate the drug properties of pKa, freezing point depression, or solubility to the water content, steady state extrusion force, median pellet diameter, its interquartile range, and its shape satisfactorily. Thus other properties of the drug must be involved in the extrusion/spheronization process. Prediction of the best water content to use in a formulation was possible for 50% of the formulations by using a nonlinear model to relate the above drug properties to the water content.
Interleukin 1 protects against 1-beta-D-arabinofuranosylcytosine-induced alopecia in the newborn rat animal model. (1991)

Alopecia is one of the most psychologically distressing side effects of cancer chemotherapy. Previously, we made the following observations: (a) treatment of 8-day-old rats with 1-beta-D-arabinofuranosylcytosine (ara-C), doxorubicin, and cyclophosphamide (CYC) consistently produced either total body alopecia (ara-C and CYC) or alopecia confined to the head and proximal part of the neck (doxorubicin); (b) Imuvert, a biological response modifier derived from the bacterium Serratia marcescens, uniformly produced complete protection against alopecia induced by ara-C and doxorubicin but not that induced by CYC; and (c) the protective effect of Imuvert against chemotherapy-induced alopecia is mediated by a monocyte-mediated cytokine. In the experiments reported here, interleukin 1 was examined as the potential cytokine. Interleukin 1 offered excellent protection against alopecia induced by ara-C but not that produced by CYC in the newborn rat animal model.
A rice homeobox gene, OSH1, is expressed before organ differentiation in a specific region during early embryogenesis. (1996)

Homeobox genes encode a large family of homeodomain proteins that play a key role in the pattern formation of animal embryos. By analogy, homeobox genes in plants are thought to mediate important processes in their embryogenesis, but there is very little evidence to support this notion. Here we described the temporal and spatial expression patterns of a rice homeobox gene, OSH1, during rice embryogenesis. In situ hybridization analysis revealed that in the wild-type embryo, OSH1 was first expressed at the globular stage, much earlier than organogenesis started, in a ventral region where shoot apical meristem and epiblast would later develop. This localized expression of OSH1 indicates that the cellular differentiation has already occurred at this stage. At later stages after organogenesis had initiated, OSH1 expression was observed in shoot apical meristem [except in the L1 (tunica) layer], epiblast, radicle, and their intervening tissues in descending strength of expression level with embryonic maturation. We also performed in situ hybridization analysis with a rice organless embryo mutant, orl1, that develops no embryonic organs. In the orl1 embryo, the expression pattern of OSH1 was the same as that in the wild-type embryo in spite of the lack of embryonic organs. This shows that OSH1 is not directly associated with organ differentiation, but may be related to a regulatory process before or independent of the organ determination. The results described here strongly suggest that, like animal homeobox genes, OSH1 plays an important role in regionalization of cell identity during early embryogenesis.
Export Of Protein: A Biochemical View (1987)

Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly pathogenic HCoVs: severe acute respiratory syndrome coronavirus (SARS-CoV) and ...Read More
MicroRNA Directs mRNA Cleavage of the Transcription Factor NAC1 to Downregulate Auxin Signals for Arabidopsis Lateral Root Development (2005)

Although several plant microRNAs (miRNAs) have been shown to play a role in plant development, no phenotype has yet been associated with a reduction or loss of expression of any plant miRNA. Arabidopsis thaliana miR164 was predicted to target five NAM/ATAF/CUC (NAC) domain-encoding mRNAs, including NAC1, which transduces auxin signals for lateral root emergence. Here, we show that miR164 guides the cleavage of endogenous and transgenic NAC1 mRNA, producing 3'-specific fragments. Cleavage was blocked by NAC1 mutations that disrupt base pairing with miR164. Compared with wild-type plants, Arabidopsis mir164a and mir164b mutant plants expressed less miR164 and more NAC1 mRNA and produced more lateral roots. These mutant phenotypes can be complemented by expression of the appropriate MIR164a and MIR164b genomic sequences. By contrast, inducible expression of miR164 in wild-type plants led to decreased NAC1 mRNA levels and reduced lateral root emergence. Auxin induction of miR164 was mirrored by an increase in the NAC1 mRNA 3' fragment, which was not observed in the auxin-insensitive mutants auxin resistant1 (axr1-12), axr2-1, and transport inhibitor response1. Moreover, the cleavage-resistant form of NAC1 mRNA was unaffected by auxin treatment. Our results indicate that auxin induction of miR164 provides a homeostatic mechanism to clear NAC1 mRNA to downregulate auxin signals.
Occlusal considerations in implant therapy: clinical guidelines with biomechanical rationale (2004)

Due to lack of the periodontal ligament, osseointegrated implants, unlike natural teeth, react biomechanically in a different fashion to occlusal force. It is therefore believed that dental implants may be more prone to occlusal overloading, which is often regarded as one of the potential causes for peri-implant bone loss and failure of the implant/implant prosthesis. Overloading factors that may negatively influence on implant longevity include large cantilevers, parafunctions, improper occlusal designs, and premature contacts. Hence, it is important to control implant occlusion within physiologic limit and thus provide optimal implant load to ensure a long-term implant success. The purposes of this paper are to discuss the importance of implant occlusion for implant longevity and to provide clinical guidelines of optimal implant occlusion and possible solutions managing complications related to implant occlusion. It must be emphasized that currently there is no evidence-based, implant-specific concept of occlusion. Future studies in this area are needed to clarify the relationship between occlusion and implant success.
Energy transfer in "parasitic" cancer metabolism (2011)

It is now widely recognized that the tumor microenvironment promotes cancer cell growth and metastasis via changes in cytokine secretion and extracellular matrix remodeling. However, the role of tumor stromal cells in providing energy for epithelial cancer cell growth is a newly emerging paradigm. For example, we and others have recently proposed that tumor growth and metastasis is related to an energy imbalance. Host cells produce energy-rich nutrients via catabolism (through autophagy, mitophagy, and aerobic glycolysis), which are then transferred to cancer cells to fuel anabolic tumor growth. Stromal cell-derived L-lactate is taken up by cancer cells and is used for mitochondrial oxidative phosphorylation (OXPHOS) to produce ATP efficiently. However, "parasitic" energy transfer may be a more generalized mechanism in cancer biology than previously appreciated. Two recent papers in Science and Nature Medicine now show that lipolysis in host tissues also fuels tumor growth. These studies demonstrate that free fatty acids produced by host cell lipolysis are re-used via beta-oxidation (beta-OX) in cancer cell mitochondria. Thus, stromal catabolites (such as lactate, ketones, glutamine and free fatty acids) promote tumor growth by acting as high-energy onco-metabolites. As such, host catabolism, via autophagy, mitophagy and lipolysis, may explain the pathogenesis of cancer-associated cachexia and provides exciting new druggable targets for novel therapeutic interventions. Taken together, these findings also suggest that tumor cells promote their own growth and survival by behaving as a "parasitic organism." Hence, we propose the term "Parasitic Cancer Metabolism" to describe this type of metabolic coupling in tumors. Targeting tumor cell mitochondria (OXPHOS and beta-OX) would effectively uncouple tumor cells from their hosts, leading to their acute starvation. In this context, we discuss new evidence that high-energy onco-metabolites (produced by the stroma) can confer drug resistance. Importantly, this metabolic chemo-resistance is reversed by blocking OXPHOS in cancer cell mitochondria with drugs like Metformin, a mitochondrial "poison." In summary, parasitic cancer metabolism is achieved architecturally by dividing tumor tissue into at least two well-defined opposing "metabolic compartments:" catabolic and anabolic.
Amyotrophic lateral sclerosis and other motor neuron diseases (1991)

Cell biology cellular pathology genetics epidemiology and environmental toxins immunology persistent viral infection clinical trials.