gebhart/patrepeval huggingface dataset:
Midline fasciclin: ADrosophila fasciclin-I-related membrane protein localized to the CNS midline cells and trachea (1998)

Drosophila Fasciclin I is the prototype of a family of vertebrate and invertebrate proteins that mediate cell adhesion and signaling. The midline fasciclin gene encodes a second Drosophila member of the Fasciclin I family. Midline Fasciclin largely consists of four 150 amino acid repeats characteristic of the Fasciclin I family of proteins. Immunostaining and biochemical analysis using Midline Fasciclin antibodies indicates that it is a membrane-associated protein, although the sequence does not reveal a transmembrane domain. The gene is expressed in a dynamic fashion during embryogenesis in the blastoderm, central nervous system midline cells, and trachea, suggesting it plays multiple developmental roles. Protein localization studies indicate that Midline Fasciclin is found within cell bodies of midline neurons and glia, and on midline axons. Initial cellular analysis of a midline fasciclin loss-of-function mutation reveals only weak defects in axonogenesis. However, embryos mutant for both midline fasciclin and the abelson nonreceptor tyrosine kinase, show more severe defects in axonogenesis that resemble fasciclin I abelson double mutant phenotypes.
Lifitegrast for the Treatment of Dry Eye Disease (2016)

Lifitegrast significantly improved symptoms of eye dryness, as measured by EDS, versus placebo in participants with DED. Improvement in EDS was observed as early as day 14. Lifitegrast appeared well tolerated.
Target Therapy Using a Small Molecule Inhibitor against Angiogenic Receptors in Pancreatic Cancer (2007)

These data highlight VEGF-RII and FGF-RI as therapeutic targets and suggest a potential role for the combined use of tyrosine kinase inhibitors in the management of inoperable pancreatic cancer patients.
Training sequence vs. cyclic prefix a new look on single carrier communication (2002)

Frequency domain equalization has gained a lot of attention in the last decade, mainly pushed by the OFDM (orthogonal frequency division multiplexing) communication scheme. It has been adopted, in various flavours, for, among others, wireless LANs and xDSL. The technique is indeed leading to low complexity implementation, at the cost of a cyclic prefix, used to avoid inter block interference (IBI). The idea has been adapted to single carrier communication, almost "as is", yielding the same computational advantages and avoiding the high crest factor of OFDM. We name this scheme CP-SC (cyclic prefix-single carrier). We take a new look at this single carrier scheme, and, with a slight modification, show that the cyclic prefix can be implemented as a training sequence, and hence play two important roles: avoid IBI and help in synchronisation and channel estimation. The latter topic is of utter importance in fast fading situations (e.g. mobile). This new training aided frequency domain equalized single carrier (we name it TASC) scheme offers these advantages at the expense of only a small fraction of a dB (in terms of E/sub b//N/sub 0/). All these arguments make TASC an interesting candidate in situations where multipath and fast fading are present, while in other situations it has hardly no drawback compared to CP-SC.
Layout and Control of Highcapacity Systems (2009)

This chapter contains sections titled: Synopsis of Chapter This chapter contains sections titled: Large Radio Coverage Area Systems Coverage Layout of Small Cell Systems Base Station Assignment in Small Cell Systems Channel Assignment in Small Cell Systems This chapter contains sections titled: References 
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The role of tumor-associated macrophages in breast carcinoma invasion and metastasis. (2015)

The main purpose of this study was to investigate the infiltration of tumor-associated macrophages (TAMs) in normal and malignant breast tissue and the draining lymph nodes, and to explore its effect on breast cancer invasion and metastasis. The infiltration densities of TAMs was observed using immunohistochemical staining of CD68 in 100 cases of breast cancer specimens and its paired adjacent non-cancer breast tissues and draining lymph modes, and then to evaluate the relation of TAMs to various clinicopathological features including patients prognosis in breast carcinoma. We observed the infiltration densities of TAMs were significantly higher in breast carcinoma tissue than in adjacent normal tissue and significantly higher in much larger size and higher stage cases. Furthermore, infiltration densities of TAMs have negative correlation with the 5-year survival rates of breast cancer patients. But in matched lymph-nodes, the infiltration densities of TAMs were significantly lower in cancerous metastatic lymph-node samples than in non-metastatic one. Therefore, our data suggests that TAMs infiltration in primary tumor promote invasion and lymphatic metastasis of breast cancer and have negative correlation with patients prognosis in breast cancer, but in lymph-node TAMs may play another role and need further study in the future.
Early Weightbearing and Ankle Mobilization after Open Repair of Acute Midsubstance Tears of the Achilles Tendon (2003)

Early weightbearing with the ankle plantigrade is not detrimental to the outcome of repair after acute rupture of the Achilles tendon and shortens the time needed for rehabilitation. However, strength deficit and muscle atrophy are not prevented.
Association of Adenovirus Infection with Human Obesity (1997)

We previously reported that chickens infected with the avian adenovirus SMAM-1 developed a unique syndrome characterized by excessive intra-abdominal fat deposition accompanied by paradoxically low serum cholesterol and triglyceride levels. There have been no previous reports of avian adenoviruses infecting humans. We screened the serum of 52 humans with obesity in Bombay, India, for antibodies against SMAM-1 virus using the agar gel precipitation test (AGPT) method. Bodyweights and serum cholesterol and triglyceride levels were compared in SMAM-1-positive (P-AGPT) and SMAM-1-negative (N-AGPT) groups. Ten subjects were positive for antibodies to SMAM-1, and 42 subjects did not have antibodies. The P-AGPT group had a significantly higher bodyweight (p < 0.02) and body mass index (p < 0.001) (95.1 +/- 2.1 kg and 35.3 +/- 1.5 kg/m2, respectively) compared with the N-AGPT group (80.1 +/- 0.6 kg and 30.7 +/- 0.6 kg/m2, respectively). Also, the P-AGPT group had significantly lower serum cholesterol (p < 0.02) and triglyceride (p < 0.001) values (4.65 mmol/L and 1.45 mmol/L, respectively) compared with the N-AGPT group (5.51 mmol/L and 2.44 mmol/L, respectively). Two subjects positive for SMAM-1 antibodies had antibodies against each others' serum, suggesting the presence of antigens in one or both. When these two serum samples were inoculated into chicken embryos, macroscopic lesions compatible with SMAM-1 infection developed. The inoculation of serum from N-AGPT subjects did not produce such lesions. The presence of increased obesity, antibodies to SMAM-1, reduced levels of blood lipids, and viremia that produces a typical infection in chicken embryos suggests that SMAM-1, or a serologically similar human virus, may be involved in the cause of obesity in some humans.
Distinct mouse bone marrow macrophage precursors identified by differential expression of ER‐MP12 and ER‐MP20 antigens (1994)

The characterization of early branch points in the differentiation of leukocytes requires identification of precursor cells in the bone marrow. Recently, we produced two monoclonal antibodies, ER-MP12 and ER-MP20, which in two-color flow-cytometric analysis divide the murine bone marrow into six defined subsets. Here we show, using fluorescence-activated cell sorting followed by macrophage colony-stimulating factor-stimulated culture in soft agar, that precursors of the mononuclear phagocyte system reside only within the ER-MP12hi20-, ER-MP12+20+ and ER-MP12-20hi bone marrow subsets. Together, these subsets comprise 15% of nucleated bone marrow cells. Furthermore, we provide evidence that the macrophage precursors present in these subsets represent successive stages in a maturation sequence where the most immature ER-MP12hi20- cells develop via the ER-MP12+20+ stage into ER-MP12-20hi monocytes.
Epidemiology of Hepatitis C in the West (1995)

Most hepatitis C occurs among young adults with high-risk behaviors or lifestyles. Although the most efficient transmission of HCV is through large or repeated percutaneous exposures to infectious blood, transmission also seems to occur through occupational exposure, sexual activity, household contact, and perinatal exposure. The risk of transmission in these settings is most likely dependent on the titer of virus as well as the type and size of the inoculum and the route of transmission. The apparent inconsistency of results between studies is probably a result of the small sample sizes, in that insufficient numbers of infectious persons are included, as well as the variations in methodology and serologic testing. Although HCV may be inefficiently transmitted by inapparent parenteral or mucosal exposures, the high rate of persistent infection with HCV creates a large reservoir of persons who are infectious to others. Current preventive measures, such as donor screening, prevent only a small proportion of the disease. Epidemiologic studies to define the risk of, and the factors facilitating transmission of HCV in other settings, still need to be conducted to develop measures to prevent most disease acquisition.
Monolithic phase-locked semiconductor laser arrays (1994)

Phase-locked arrays of diode lasers have been studied extensively over the last 15 years. Such devices have been pursued in the quest to achieve high coherent powers (> 100 mW diffraction limited) for applications such as space communications, blue-light generation via frequency doubling, optical interconnects, parallel optical-signal processing, high-speed, high-resolution laser printing and end-pumping solid-state lasers. Conventional, narrow-stripe (3–4 μm wide), single-mode lasers provide, at most, 100 mW reliably, as limited by the optical power density at the laser facet. For reliable operation at watt-range power levels, large-aperture (≥100 µm) sources are necessary. Thus, the challenge has been to obtain single-spatial-mode operation from large-aperture devices, and maintain stable, diffraction-limited-beam behavior to high power levels (0.5–1.0 W).
Analysis of intestinal fibrosis in chronic colitis in mice induced by dextran sulfate sodium (2011)

Fibrogenic mesenchymal cells including fibroblasts and myofibroblasts play a key role in intestinal fibrosis, however, their precise role is largely unknown. To investigate their role in intestinal fibrosis, we analyzed the lesions of chronic colitis in C57BL/6 (B6) mice induced by dextran sulfate sodium (DSS). B6 mice exposed to single cycle administration of DSS for 5 days developed acute colitis that progressed to severe chronic inflammation with dense infiltrates of mononuclear cells, irregular epithelial structure, thickening of colonic wall, and persistent deposits of collagen. Increased mRNA expressions of proinflammatory cytokines are correlated with extensive cellular infiltration, and the mRNA expressions of collagen 1, transforming growth factor (TGF)-β, and matrix metalloproteinases were also enhanced in the colon. In the colon of chronic DSS colitis, fibroblasts (vimentin(+), α-smooth muscle actin (α-SMA)(-)) were increased in both mucosal and submucosal layers, while myofibroblasts (vimentin(+), α-SMA(+)) were increased in mucosal but not in submucosal layers. Primary mouse subcutaneous fibroblast cultures experiments revealed that exogenously added TGF-β 1 substantially augmented the expressions of both vimentin and α-SMA proteins with increased production of collagen. In conclusion, profibrogenic mesenchymal cells play an important role in the development of intestinal fibrosis in this chronic DSS-induced colitis model.
[Chemokines and the regulation of hematopoiesis]. (1998)

Chemokines are a large family of cytokines that act not only as immune and inflammatory regulators but also as regulators of hematopoiesis. Two major subfamilies of chemokines are distinguished on the basis of whether the first two cysteines are separated by a single residue (CXC) or three residues (CX3C) or they are adjacent (CC) or there is a single C. The Macrophage Inflammatory Protein 1 alpha (MIP-1 alpha), which belongs to CC family is a powerful inhibitor of hematopoisis in vitro and in vivo. The sub-family CXC comprises two main groups. The first sub-group includes the ELR chemokines, in which interleukin-8 (IL-8) is the most prototypic and possesses suppressive activities on hematopoiesis. Platelet Factor 4 (PF4) belongs to the sub-group of non-ELR CXC chemokines. PF4 acts as an inhibitor of hematopoiesis, particularly of the megakaryocytopoiesis. Recently, it has been shown that a peptide of PF4, 34-58 which does not contain the site of heparin binding, is able to inhibit the growth of hematopoietic progenitors in vitro, providing evidence for a model of heparin dependent and independent pathways of PF4 action on hematopoiesis. PF4 can reduce the chimiosensitivity of hematopoietic cells in mice treated by the cytotoxic drug 5-Fluorouracyl, suggesting a potential clinical application of PF4 in cancer therapy.
Maternal histone deacetylase is accumulated in the nuclei of Xenopus oocytes as protein complexes with potential enzyme activity (1999)

Reversible acetylation of core histones plays an important regulatory role in transcription and replication of chromatin. The acetylation status of chromatin is determined by the equilibrium between activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). The Xenopus protein HDACm shows sequence homology to other putative histone deacetylases, but its mRNA is expressed only during early development. Both HDACm protein and acetylated non-chromosomal histones are accumulated in developing oocytes, indicating that the key components for histone deposition into new chromatin during blastula formation are in place by the end of oogenesis. Here we show that the 57 kDa HDACm protein undergoes steady accumulation in the nucleus, where it is organized in a multiprotein complex of approx. 300 kDa. A second, major component of the nuclear complex is the retinoblastoma-associated protein p48 (RbAp48/46), which may be used as an adaptor to contact acetylated histones in newly assembled chromatin. The nuclear complex has HDAC activity that is sensitive to trichostatin A, zinc ions and phosphatase treatment. The 57 kDa protein serves as a marker for total HDAC activity throughout oogenesis and early embryogenesis. The active HDACm complex and its acetylated histone substrates appear to be kept apart until after chromatin assembly has taken place. However, recombinant HDACm, injected into the cytoplasm of oocytes, not only is translocated to the nucleus, but also is free to interact with the endogenous chromatin.
Providing policy control over object operations in a mach based system (1995)

In both secure and safety-critical systems it is desirable to have a very clear relationship between the system&amp;apos;s mandatory security pol-icy and its proven operational semantics. This relationship is made clearer if the system ar-chitecture provides strong separation between the enforcement mechanisms and the policy decisions, and if the policy decision software is clearly identi®able in the system&amp;apos;s architec-ture. This paper describes a prototype Unix sys-tem based on Mach which provides manda-tory control over all kernel-supported opera-tions. The prototype work modi®ed the Mach kernel by extending its limited control mech-anisms based on the Mach port right. The control extensions allow a mandatory control policy to specify control over not only access to an object via a port right, but over the indi-vidual services supported by the object. The mandatory security policy is implemented in an external Security Server which provides very strong separation between policy enforce-ment and policy decision software. This makes it possible to support a wide range of security policies with no change to the kernel or appli-cations. 1
TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1 (1994)

The rejection of the transplanted allograft is dependent on T cell activation, which requires T cell receptor engagement by antigen and costimulatory signals delivered by T cell surface molecules such as CD28. CTLA4-Ig is a fusion protein that has previously been shown to block the CD28-mediated costimulatory signal and inhibit immune responses in vitro and in vivo. In this report we show that treatment of the C3H/He recipient of a BALB/c vascularized cardiac allograft with a 12-day course of CTLA4-Ig produced indefinite graft survival (> 100 days) in the majority of recipients. In addition, these recipients demonstrated donor-specific transplantation tolerance when tested with donor-specific (BALB/c) and third-party (C57BL/10) skin grafts. These results demonstrate that CTLA4-Ig can induce transplantation tolerance in the adult murine cardiac allograft model.
Reduction of arsenate to arsenite by the ArsC protein of the arsenic resistance operon of Staphylococcus aureus plasmid pI258. (1992)

The arsenic resistance operon of Staphylococcus aureus plasmid pI258 consists of three genes, arsR (encoding the repressor regulatory protein), arsB (the determinant of the membrane efflux protein that confers resistance by pumping arsenic from the cells), and arsC (the small gene whose protein product is required for arsenate resistance only, not for arsenite resistance). ArsC has now been shown to be an arsenate reductase, converting intracellular arsenate [As(V)] to arsenite [As(III)], which is then exported from the cells by an energy-dependent efflux process. The arsenate reductase activity was found in the soluble cytoplasmic fraction in Escherichia coli (and not associated with the periplasmic fraction or the sedimentable cell envelope). Purified ArsC protein coupled in vitro with thioredoxin plus dithiothreitol (but not 2-mercaptoethanol or reduced glutathione) to reduce arsenate to arsenite.
Maximum Likelihood from Incomplete Data Via the EM Algorithm (1977)

Summary A broadly applicable algorithm for computing maximum likelihood estimates from incomplete data is presented at various levels of generality. Theory showing the monotone behaviour of the likelihood and convergence of the algorithm is derived. Many examples are sketched, including missing value situations, applications to grouped, censored or truncated data, finite mixture models, variance component estimation, hyperparameter estimation, iteratively reweighted least squares and factor analysis.
Retargeting T Cells for HER2-Positive Tumor Killing by a Bispecific Fv-Fc Antibody (2013)

To exploit the biological and pharmacological properties of immunoglobulin constant domain Fc fragment and increase the killing efficacy of T cells, a single chain variable fragment specific to CD3 was fused with Fcab (Fc antigen binding), a mutant Fc fragment with specificity against Human epidermal growth factor receptor 2 (HER2) developed by F-star. The bispecific fusion named as FcabCD3 was expressed by transient transfection in HEK-293T cells and purified by affinity chromatography. Specific cytolytic activity of retargeted T cells to kill HER2 positive SKBR3 cell line was evaluated in vitro. FcabCD3 was able to retarget T cells to kill both Herceptin insensitive Colo205-luc cell line and HER2 low expression MDA-MB-231-luc cell line. Furthermore, FcabCD3 was effective in eliminating the Colo205 tumor established on BALB/c nu/nu mice.
Oriented Surface Dipoles Strongly Influence Interfacial Wettabilities (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTOriented Surface Dipoles Strongly Influence Interfacial WettabilitiesMichael Graupe, Mitsuru Takenaga, Thomas Koini, Ramon Colorado, and T. Randall LeeView Author Information Department of Chemistry, University of Houston Houston, Texas 77204-5641 Cite this: J. Am. Chem. Soc. 1999, 121, 13, 3222–3223Publication Date (Web):March 20, 1999Publication History Received13 October 1998Revised22 January 1999Published online20 March 1999Published inissue 1 April 1999https://pubs.acs.org/doi/10.1021/ja983582hhttps://doi.org/10.1021/ja983582hrapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views1058Altmetric-Citations111LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Halogenation,Liquids,Noncovalent interactions,Surface interactions Get e-Alerts
C-Terminal Region of Outer Surface Protein C Binds Borreliacidal Antibodies in Sera from Patients with Lyme Disease (2003)

Borreliacidal antibodies specific for outer surface protein C (OspC) are induced shortly after infection with Borrelia burgdorferi. In this study, we identified the region of OspC recognized by immunoglobulin M (IgM) and IgG borreliacidal antibodies. Sera from patients with early Lyme disease were screened for borreliacidal activity specific for B. burgdorferi 50772 and OspC antibodies. Seven sera that contained similarly high titers of each response were then chosen randomly and adsorbed with OspC or a truncated OspC (OspC-Dra) containing the 50 amino acids nearest the carboxy terminus. Adsorption with OspC or OspC-Dra completely eliminated the borreliacidal activity in six (86%) of seven sera and significantly decreased the activity in the remaining serum (titer of 10,240 to 1,280). Moreover, OspC antibodies were no longer detected by OspC enzyme-linked immunosorbent assay or in a Western blot that contained native OspC. The findings confirmed that sera from patients with early Lyme disease contain high concentrations of IgM or IgG borreliacidal antibodies that bind a conserved region of OspC.
Role of Si1−xGex buffer layer on mobility enhancement in a strained-Si n-channel metal–oxide–semiconductor field-effect transistor (1999)

Strained-Si n-channel metal–oxide–semiconductor field-effect transistors (MOSFETs) were fabricated on molecular-beam epitaxially grown strained Si with various Si1−xGex buffer layers. Effective electron mobility in n-MOSFETs with a Si1−xGex (x=0.2, 0.3) graded buffer layer was 60% higher than that in an unstrained-Si n-MOSFET. However, mobility of samples with a Si1−xGex buffer layer on a low-temperature grown Si buffer layer was not increased as much as that of samples on a graded buffer layer. Atomic-force microscopic observation suggests that the power spectrum of surface roughness of the strained-Si layer varies according to the buffer layer, and this variation may affect the enhancement of mobility.