gebhart/patrepeval huggingface dataset:
<title>Multilevel character templates for document image decoding</title> (1997)

Early work in document image decoding was based on a bilevel imaging model in which an observed image is formed by passing an ideal bilevel image through a memoryless asymmetric bit-flip channel. While this simple model has proven useful in practice, there are many situations in which the bit-flip channel is an inadequate degradation mode. This paper presents a multilevel generalization of the bilevel model in which the pixels of the ideal image are assigned values from a finite set of L discrete 'levels. Level 0 is a background color and the remaining levels are foreground colors. The observed image is bilevel and is modelled as the output of a memoryless L-input symbol, 2- output symbol, 2-output symbol channel. The multilevel model is motivated in part by the intuition that pixel sin a character image are more or less reliably black, depending on their distance from an edge. In addition, the multilevel model supports both 'write-black' and 'write-write' levels, and thus can be used to implement a probabilistic analog of morphological 'hit-miss' filtering. In experiments with the University of Washington UW-II English journal database, the character error rate with multilevel templates was about a factor of four less than the error rate with bilevel templates.
High spatial resolution single multiwalled carbon nanotube electrode for stimulation, recording, and whole cell voltage clamping of electrically active cells (2009)

We report the stimulation, recording, and voltage clamp of muscle fibers using a 30 nm diameter single multiwalled carbon nanotube electrode (sMWNT electrode) tip. Because of the lower access resistance, the sMWNT electrode conducts extracellular and intracellular stimulation more efficiently compared to glass micropipettes. The sMWNT electrode records field potentials and action potentials and performs whole cell voltage clamping of single fibers.
Engagement of CD33 surface molecules prevents the generation of dendritic cells from both monocytes and CD34+ myeloid precursors (2000)

Although CD33 represents an important marker of myeloid cell differentiation, its function remains poorly defined. In view of its homology with p75 / AIRM1, a recently identified surface molecule which exerts a potent inhibition on NK cell function, we re-evaluated the effect of CD33 engagement in defined myeloid cell functions. Addition of anti-CD33 mAb to cultures of CD14+ monocytes supplemented with granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-4 and TNF-α, prevented the generation of dendritic cells. In these cultured cells, engagement of CD33 resulted in an increased surface binding of annexin-V, followed by cell death. Mature dendritic cells were resistant to the CD33-mediated effect. Also in CD34+ precursors, cultured in the presence of flt3-ligand, c-Kit-ligand, GM-CSF, IL-4 and TNF-α, addition of anti-CD33 mAb prevented the recovery of mature dendritic cells. These data suggest a regulatory role of CD33 in the myeloid cell maturation and may offer a tool to interfere with the monocyte / macrophage cell function as well as with the development of dendritic cells.
Study on system latency reduction based on Shorten TTI (2016)

System latency is one key metric that guides LTE design. Shortening TTI by reducing subframe length along with backward compatibility design can bring significant latency gains for legacy LTE systems. In general, it is believed that the shorter TTI is, the more gain can be achieved. However, due to the hardware limitation as well as the implementation complexity, it is not easy for ultra-short TTI lengths to adapt to legacy LTE. Therefore, to maximize the latency gain with relative longer TTI length (slot level TTI), this paper proposes another method including reducing UL access delay and HARQ ACK/NACK RTT. It can be verified that combining slot TTI, this method can reduce 45.58% and 40.56% latency at low traffic load for cell edge and center users, higher than the 40.29% and 39.51% latency reduction brought by very short TTIs.
Clinical and Laboratory Characteristics of Human Granulocytic Ehrlichiosis (1996)

Human granulocytic ehrlichiosis is being increasingly recognized in Wisconsin and Minnesota. A more severe illness is associated with increased age, anemia, increased percentage of neutrophils and decreased percentage of lymphocytes in peripheral blood, and presence of morulae in neutrophils. The differential diagnosis for patients who develop an influenzalike illness following a tick bite should include HGE. Microscopic examination of the acute-phase blood smear to detect neutrophilic morulae is currently the quickest and most practical screening method for diagnosing HGE in the upper Midwest.
sunTILL: a TILLING resource for gene function analysis in sunflower (2011)

A first TILLING population for a high throughput identification of EMS-induced point mutations in sunflower genome has been successfully obtained. This represents a powerful tool to a better understanding of gene function in sunflower.
Crystal structure of a disulfide-linked "trefoil" motif found in a large family of putative growth factors. (1994)

Porcine pancreatic spasmolytic polypeptide (PSP) belongs to a large family of homologous growth factor-like polypeptides characterized by a disulfide-linked "trefoil motif," duplicated and conserved in various family members. PSP contains two trefoil motifs, has several pharmacological actions on the gut, and has growth factor properties on epithelial cells in vitro. The human PSP analogue, human spasmolytic polypeptide, appears to be involved in many regenerative situations and, especially, in healing gastrointestinal ulcers. One member of the trefoil family, pS2, is secreted in approximately 50% of estrogen-dependent human breast carcinomas, which has led to its use as a tumor prognostic marker. Both pS2 and human spasmolytic polypeptide are also widely expressed in chronic gastrointestinal ulcerative conditions such as Crohn disease. Here we report the three-dimensional structure at 2.6-A resolution of a trefoil-containing protein, namely PSP, purified from porcine pancreas. The structure shows two homologous domains that share a supersecondary structure and disulfide bond pattern. The two domains pack asymmetrically giving rise to a number of protruding loops, exposed clefts, and an unusual electrostatic surface potential. Knowledge of the structure of PSP should allow the design of mutants to investigate further the function of PSP and other trefoil-containing peptides.
Synthesis and Structural Characterization of Highly Chlorinated, Brominated, Iodinated, and Methylated Carborane Anions, 1-H-CB9X9-, 1-NH2-CB9X9- (X = Cl, Br, I), and 1-H-CB9(CH3)9- (2000)

The highly chlorinated, brominated, and iodinated carborane anions 1-R-CB9X9- (R = H, NH2; X = Cl, Br, I) were prepared in high yields by treatment of [Me3NH][1-R-CB9H9] with excess ICl, Br2/triflic acid, and I2/triflic acid, respectively, in sealed tubes at 180-240 degrees C. With the aid of a Pd catalyst, B-I bonds could be converted into the B-Me bonds by treatment with excess MeMgBr, which led to the preparation of the permethylated species 1-H-CB9Me9- in good yield. These new anions were fully characterized by 1H, 13C, and 11B NMR, IR, and negative-ion MALDI MS spectroscopy. Some were further characterized by single-crystal X-ray analyses. The weakly coordinating nature of these new anions was probed by 29Si chemical shifts.
Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. (1994)

TCR rearrangements were used to probe the clonal origin of myelin basic protein (MBP)-reactive T cells from patients with multiple sclerosis (n = 7) and normal subjects (n = 3). The majority of MBP-specific T cell lines were specific for the immunodominant MBP(84-102) and MBP(143-168) peptides and were restricted by HLA-DR molecules. In two patients with the DR2 haplotype, the T cell response to MBP was focused on the MBP(84-102) peptide. In both patients, in vivo expanded population(s) (three expanded populations in the first patient, one expanded population in the second patient) dominated the response to the MBP(84-102) peptide. Two MBP(84-102)-specific T cell clones from a normal subject with the DR2 haplotype were also found to have identical TCR sequences. Clonality was proven by demonstrating that independent clones had identical TCR alpha- and TCR beta-chain sequences as well as identical sequences of a TCR gamma-chain or of a second TCR alpha-chain rearrangement. Repeated analysis of one patient after 13 mo demonstrated that the three expanded clones had persisted in vivo. A representative of one of the expanded clones was again obtained after 31 mo by IL-2 stimulation suggesting that this clone was activated in vivo. These data suggest that the response to human MBP is dominated in at least some subjects by expanded clones that may persist in vivo for relatively long periods of time.
Influence of CD14 on Ligand Interactions between Lipopolysaccharide and Its Receptor Complex (2005)

The interaction of LPS (endotoxin) with the CD14-TLR4 receptor complex modulates the host innate immune response. Several studies using partial structures of LPS have suggested that TLR4 determines the ligand specificity of this complex, and that CD14 indiscriminately serves to deliver the ligand to TLR4. This conclusion has been made despite observations that the response of TLR4(+/+),CD14(-/-) macrophages to LPS is very weak. To determine whether CD14 itself plays a role in specific ligand recognition, the influences of various partial structures of LPS on induction of the proinflammatory cytokine, TNF, by CD14(+/+) and CD14(-/-) macrophages were compared. These studies show that the ligand specificities of CD14(+/+) and CD14(-/-) macrophages are very different. When CD14 is present, the receptor complex shows exquisite specificity for smooth LPS, the major form expressed by Gram-negative bacteria; however, as increasing amounts of carbohydrate are removed from smooth LPS, the sensitivity of CD14(+/+) macrophages decreases as much as 500-fold. In contrast, CD14(-/-) macrophages are unable to distinguish between smooth LPS and its various partial structures. Furthermore, CD14(-/-) macrophages are 150,000-fold less sensitive than CD14(+/+) macrophages to smooth LPS. A similar ability to distinguish the differing LPS structures of various bacteria such as Bacteroides fragilis and Salmonella abortus are observed for CD14(+/+), but not CD14(-/-), macrophages. Thus, CD14(+/+), but not CD14(-/-), macrophages are highly sensitive to stimulation by natural forms of LPS and show the ability to distinguish between various LPS ligands, consistent with CD14 being a highly specific receptor.
Safety Assessment of Cyclomethicone, Cyclotetrasiloxane, Cyclopentasiloxane, Cyclohexasiloxane, and Cycloheptasiloxane (2011)

Cyclomethicone (mixture) and the specific chain length cyclic siloxanes (n = 4-7) reviewed in this safety assessment are cyclic dimethyl polysiloxane compounds. These ingredients have the skin/hair conditioning agent function in common. Minimal percutaneous absorption was associated with these ingredients and the available data do not suggest skin irritation or sensitization potential. Also, it is not likely that dermal exposure to these ingredients from cosmetics would cause significant systemic exposure. The Cosmetic Ingredient Review Expert Panel concluded that these ingredients are safe in the present practices of use and concentration.
3D hierarchical spatial representation and memory of multimodal sensory data (2009)

This paper describes an efficient method and system for representing, processing and understanding multi-modal sensory data. More specifically, it describes a computational method and system for how to process and remember multiple locations in multimodal sensory space (e.g., visual, auditory, somatosensory, etc.). The multimodal representation and memory is based on a biologically-inspired hierarchy of spatial representations implemented with novel analogues of real representations used in the human brain. The novelty of the work is in the computationally efficient and robust spatial representation of 3D locations in multimodal sensory space as well as an associated working memory for storage and recall of these representations at the desired level for goal-oriented action. We describe (1) A simple and efficient method for human-like hierarchical spatial representations of sensory data and how to associate, integrate and convert between these representations (head-centered coordinate system, body-centered coordinate, etc.); (2) a robust method for training and learning a mapping of points in multimodal sensory space (e.g., camera-visible object positions, location of auditory sources, etc.) to the above hierarchical spatial representations; and (3) a specification and implementation of a hierarchical spatial working memory based on the above for storage and recall at the desired level for goal-oriented action(s). This work is most useful for any machine or human-machine application that requires processing of multimodal sensory inputs, making sense of it from a spatial perspective (e.g., where is the sensory information coming from with respect to the machine and its parts) and then taking some goal-oriented action based on this spatial understanding. A multi-level spatial representation hierarchy means that heterogeneous sensory inputs (e.g., visual, auditory, somatosensory, etc.) can map onto the hierarchy at different levels. When controlling various machine/robot degrees of freedom, the desired movements and action can be computed from these different levels in the hierarchy. The most basic embodiment of this machine could be a pan-tilt camera system, an array of microphones, a machine with arm/hand like structure or/and a robot with some or all of the above capabilities. We describe the approach, system and present preliminary results on a real-robotic platform.
Dripping and jetting in microfluidic multiphase flows applied to particle and fibre synthesis (2013)

Dripping and jetting regimes in microfluidic multiphase flows have been investigated extensively, and this review summarizes the main observations and physical understandings in this field to date for three common device geometries: coaxial, flow-focusing and T-junction. The format of the presentation allows for simple and direct comparison of the different conditions for drop and jet formation, as well as the relative ease and utility of forming either drops or jets among the three geometries. The emphasis is on the use of drops and jets as templates for microparticle and microfiber syntheses, and a description is given of the more common methods of solidification and strategies for achieving complex multicomponent microparticles and microfibers.
Immunization with a P53 synthetic long peptide vaccine induces P53‐specific immune responses in ovarian cancer patients, a phase II trial (2009)

The prognosis of ovarian cancer, the primary cause of death from gynecological malignancies, has only modestly improved over the last decades. Immunotherapy is one of the new treatment modalities explored for this disease. To investigate safety, tolerability, immunogenicity and obtain an impression of clinical activity of a p53 synthetic long peptide (p53-SLP) vaccine, twenty patients with recurrent elevation of CA-125 were included, eighteen of whom were immunized 4 times with 10 overlapping p53-SLP in Montanide ISA51. The first 5 patients were extensively monitored for toxicity, but showed no > or = grade 3 toxicity, thus accrual was continued. Overall, toxicity was limited to grade 1 and 2, mostly locoregional, inflammatory reactions. IFN-gamma producing p53-specific T-cell responses were induced in all patients who received all 4 immunizations as measured by IFN-gamma ELISPOT. An IFN-gamma secretion assay showed that vaccine-induced p53-specific T-cells were CD4(+), produced both Th1 and Th2 cytokines as analyzed by cytokine bead array. Notably, Th2 cytokines dominated the p53-specific response. P53-specific T-cells were present in a biopsy of the last immunization site of at least 9/17 (53%) patients, reflecting the migratory capacity of p53-specific T-cells. As best clinical response, stable disease evaluated by CA-125 levels and CT-scans, was observed in 2/20 (10%) patients, but no relationship was found with vaccine-induced immunity. This study shows that the p53-SLP vaccine is safe, well tolerated and induces p53-specific T-cell responses in ovarian cancer patients. Upcoming trials will focus on improving T helper-1 polarization and clinical efficacy.
Human Factor IX Corrects the Bleeding Diathesis of Mice With Hemophilia B (1998)

Mice with hemophilia B have been engineered using gene targeting techniques. These animals exhibit severe factor IX deficiency and a clinical phenotype that mirrors the human disease. We have bred the founder animals onto two different strains of mice, C57B1/6 and CD-1, and have sought to determine whether adenoviral vectors expressing human factor IX could correct the bleeding diathesis of mice with hemophilia B. Initial experiments showed that purified plasma-derived human factor IX added to murine factor IX–deficient plasma resulted in complete correction of the activated partial thromboplastin time (aPTT), and that injection of 1011 particles of an adenoviral vector expressing human factor IX resulted in normalization of a modified aPTT in mouse plasma. As an additional method of assessing the function of human factor IX in the murine coagulation system, bleeding times were performed in normal, hemophilic, and adenoviral-treated hemophilic mice. By two different bleeding-time techniques, the treated hemophilic mice gave values identical to normal littermate controls, whereas the untreated hemophilic mice exhibited heavy blood loss and prolonged bleeding. There was a marked difference in antibody formation in the two strains of mice; 100% of the hemophilic CD-1 mice formed antibodies to human factor IX, but none of the C57B1/6 mice did. These data suggest that the C57B1/6 hemophilic mice will be more useful for gene transfer studies, while the CD-1 hemophilic mice may be of greater utility in studying the development of inhibitors.
Down to the Wire: Calumet Horse Farm and First National Bank Win by a Nose. How an '05 Appeals Court Decision Affects Finality in Wire Transfers (2006)

To date, syntactic priming in sentence production has been investigated categorically, in terms of the probabilities of reusing particular syntactic structures. In this paper, we report a web-based replication of Pickering and Branigan (1998), Experiment 1, using a typed sentence completion paradigm that made it possible to record not only the responses made but also the response onset latency for each sentence completion. In conditions where priming occurred (as determined categorically), responses took less time when target completions were of the same type as preceding prime completions than when they differed. As well as validating Internet-based research by direct comparison with laboratory-based work, our findings strengthen the support for an architectural account of syntactic priming as envisaged by Pickering and Branigan.
Self-Assembly, Symmetry, and Molecular Architecture:  Coordination as the Motif in the Rational Design of Supramolecular Metallacyclic Polygons and Polyhedra (1997)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelf-Assembly, Symmetry, and Molecular Architecture: Coordination as the Motif in the Rational Design of Supramolecular Metallacyclic Polygons and PolyhedraPeter J. Stang and Bogdan OlenyukView Author Information Department of Chemistry, The University of Utah, Salt Lake City, Utah 84112 Cite this: Acc. Chem. Res. 1997, 30, 12, 502–518Publication Date (Web):December 16, 1997Publication History Received19 May 1997Published online16 December 1997Published inissue 1 December 1997https://pubs.acs.org/doi/10.1021/ar9602011https://doi.org/10.1021/ar9602011research-articleACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views8287Altmetric-Citations1256LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Group theory,Ligands,Self organization,Supramolecular structures and assemblies,Transition metals Get e-Alerts
Understanding the Health Impacts and Risks of Exposure to Radiation (2014)

In this chapter, the biological effects of exposure to radiation are summarized and explained from the perspective of the Fukushima Daiichi accident. First, a series of fundamental concepts in radiation biology are addressed to define the different types and sources of ionizing radiation, and resulting paths of human exposure. The health effects prompted by exposure to radiation are then broadly categorized and correlated with the nature of exposure and its extent. Finally, those concepts are revisited to assess the potential health impacts and risks endured by the workers and general population affected by the uncontrolled release of radiation around the Fukushima area. In the wake of the 2011 accident, a surge of public concern over the safety of nuclear energy and potential health risks from radiation exposure has re-surfaced. To evaluate, understand, and mitigate those health risks, it is essential that scientific data be meticulously gathered, rigorously analyzed, and accurately communicated. Taking a systematic knowledge-based approach to accurately capture the risks of exposure to radiation will not only alleviate mass confusion, but also help public health officials and emergency responders better prepare and implement logistics, should another such unfortunate event take place. The topics discussed in this chapter are intended to provide basic tools for understanding how health effects and risks related to radiation exposure are evaluated.