gebhart/patrepeval huggingface dataset:
Nontraditional Signaling Mechanisms of Lipoprotein Receptors (2009)

The low-density lipoprotein receptor family consists of a large number of single transmembrane proteins that are involved both in endocytosis of extracellular ligands and in intracellular signaling processes. New evidence ties these receptors to the transactivation of Trk receptors. Thus, this single receptor family demonstrates several distinct mechanisms for transducing information across the plasma membrane.
The development of the tumor vascular-disrupting agent ASA404 (vadimezan, DMXAA): current status and future opportunities (2010)

ASA404 is a tumor-VDA that offers considerable potential to improve outcomes in cancer patients in combination with existing treatments.
Targeting miR-21 for the Therapy of Pancreatic Cancer (2013)

Despite tremendous efforts worldwide from clinicians and cancer scientists, pancreatic ductal adenocarcinoma (PDA) remains a deadly disease for which no cure is available. Recently, microRNAs (miRNAs) have emerged as key actors in carcinogenesis and we demonstrated that microRNA-21 (miR-21), oncomiR is expressed early during PDA. In the present study, we asked whether targeting miR-21 in human PDA-derived cell lines using lentiviral vectors (LVs) may impede tumor growth. We demonstrated that LVs-transduced human PDA efficiently downregulated miR-21 expression, both in vitro and in vivo. Consequently, cell proliferation was strongly inhibited and PDA-derived cell lines died by apoptosis through the mitochondrial pathway. In vivo, miR-21 depletion stopped the progression of a very aggressive model of PDA, to induce cell death by apoptosis; furthermore, combining miR-21 targeting and chemotherapeutic treatment provoked tumor regression. We demonstrate herein for the first time that targeting oncogenic miRNA strongly inhibit pancreatic cancer tumor growth both in vitro and in vivo. Because miR-21 is overexpressed in most human tumors; therapeutic delivery of miR-21 antagonists may still be beneficial for a large number of cancers for which no cure is available.
IMMUNOTHERAPEUTIC POTENTIAL IN GUINEA-PIG TUMOR MODEL OF DEOXYRIBONUCLEIC ACID FROM MYCOBACTERIUM BOVIS BCG COMPLEXED WITH POLY-L-LYSINE AND CARBOXYMETHYLCELLULOSE (1990)

In vivo antitumor activity of a deoxyribonucleic acid fraction obtained from Mycobacterium bovis BCG (named MY-1) increased when it was complexed with poly-L-lysine (poly LL) solubilized by addition of carboxymethylcellulose (CMC). The complex of MY-1 and poly LL/CMC induced interferon in vivo at a low dose of MY-1 which alone exerted no IFN induction. With Line 10 hepatoma (L10) which is syngeneic with strain 2 guinea pigs, it was demonstrated that repeated intralesional injections of the complex resulted in delay of tumor growth and complete cure of animals from L10 tumor inoculated. Similar treatment of the animals with the same amount of MY-1 or poly LL/CMC alone had little therapeutic effect on the tumor growth.
Actual Causes of Death in the United States, 2000 (2004)

These analyses show that smoking remains the leading cause of mortality. However, poor diet and physical inactivity may soon overtake tobacco as the leading cause of death. These findings, along with escalating health care costs and aging population, argue persuasively that the need to establish a more preventive orientation in the US health care and public health systems has become more urgent.
Antimicrobial activity and spectrum of LB20304, a novel fluoronaphthyridone (1997)

Compound LB20304 is a fluoronaphthyridone carboxylic acid with a novel pyrrolidine substituent. This drug was compared with ciprofloxacin, levofloxacin, ofloxacin, and trovafloxacin against over 800 pathogens, most from blood stream infections, by National Committee for Clinical Laboratory Standards reference methods. LB20304 was the most active agent against gram-positive species including strains observed to be resistant to other fluoroquinolones and glycopeptides. The potency of LB20304 (MIC50, 0.03 micrograms/ml) against the Enterobacteriaceae was exceeded only by that of ciprofloxacin (0.015 micrograms/ml). It has limited activity against gram-negative anaerobes.
DISPERSION IN DISORDERED POROUS MEDIA (1983)

We report results of Monte Carlo investigations of dispersion in one- and two-phase flow through disordered porous media represented by square and simple cubic networks of pores of random radii. Dispersion results from the different flow paths and consequent different transit limes available to tracer particles crossing from one plane to another in a porous medium. Dispersion is found to be diffusive for the process simulated, i.e., a concentration front of solute particles can be described macroscopically by a convective diffusion equation. Dispersivity in the direction of mean flow, i.e., longitudinal dispersivity, is found to be an order of magnitude larger than dispersivity transverse to the direction of mean flow. In two-phase flow, longitudinal dispersivity in a given phase increases greatly as the saturation of that phase approaches its percolation threshold; transverse dispersivity also increases, but more slowly. As the percolation threshold is neared, the backbone of the sublatlice occupied by the phase becomes increasingly tortuous, with numerous subloops which provide alternate particle paths that are evidently highly effective in dispersing a concentration front of tracer particles.
Selective reductive displacement of alkyl halides and sulfonate esters with cyanoborohydride reagents in hexamethylphosphoramide (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective reductive displacement of alkyl halides and sulfonate esters with cyanoborohydride reagents in hexamethylphosphoramideRobert O. Hutchins, Duraisamy Kandasamy, Cynthia A. Maryanoff, Divakar Masilamani, and Bruce E. MaryanoffCite this: J. Org. Chem. 1977, 42, 1, 82–91Publication Date (Print):January 1, 1977Publication History Published online1 May 2002Published inissue 1 January 1977https://pubs.acs.org/doi/10.1021/jo00421a016https://doi.org/10.1021/jo00421a016research-articleACS PublicationsRequest reuse permissionsArticle Views683Altmetric-Citations83LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A possible central mechanism in autism spectrum disorders, part 3: the role of excitotoxin food additives and the synergistic effects of other environmental toxins. (2009)

There is compelling evidence from a multitude of studies of various design indicating that foodborne excitotoxin additives can elevate blood and brain glutamate to levels known to cause neurodegeneration and in the developing brain, abnormal connectivity. Excitotoxins are also secreted by microglial activation when they are in an activated state. Recent studies, discussed in part 1 of this article, indicate that chronic microglial activation is common in the autistic brain. The interaction between excitotoxins, free radicals, lipid peroxidation products, inflammatory cytokines, and disruption of neuronal calcium homeostasis can result in brain changes suggestive of the pathological findings in cases of autism spectrum disorders. In addition, a number of environmental neurotoxins, such as fluoride, lead, cadmium, and aluminum, can result in these pathological and biochemical changes.
Interdigitated array electrode diffusion measurements in donor/acceptor solutions in polyether electrolyte solvents (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInterdigitated array electrode diffusion measurements in donor/acceptor solutions in polyether electrolyte solventsHiroshi. Nishihara, Frank. Dalton, and Royce W. MurrayCite this: Anal. Chem. 1991, 63, 24, 2955–2960Publication Date (Print):December 15, 1991Publication History Published online1 May 2002Published inissue 15 December 1991https://pubs.acs.org/doi/10.1021/ac00024a028https://doi.org/10.1021/ac00024a028research-articleACS PublicationsRequest reuse permissionsArticle Views160Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
UV induced formation of transparent Au–Ag nanowire mesh film for repairable OLED devices (2012)

The next generation of optoelectronic devices requires transparent conductive electrodes to be flexible, cheap, and compatible with large scale manufacturing processes. Indium Tin Oxide (ITO) electrodes are often used due to their superior transparency and conductance, however they are brittle, expensive and their fabrication requires vacuum conditions which restrict scale-up. One possible alternative to the traditional ITO electrode is the metal nanowire mesh (MNWM) electrode, which is transparent, conductive, flexible and easy to produce. In this work we present the preparation and characterization of a simple organic light emitting diode (OLED) device based on a transparent electrode made of ultrathin MNWM and a comparison to an ITO based device. We have found that MNWM electrodes offer a suitable alternative to ITO electrodes in OLED devices. We have also found that the failure rate for devices due to short circuits between the top and bottom electrodes was smaller in MNWM based devices compared to ITO based devices since the MNWM devices could be repaired to present normal OLED behavior by selectively burning the nanowires forming the short. The ability to “heal” organic devices presents an important advantage and also allows for future uses in applications such as roll to roll printing.
A Correction to the Earth's Obliquity Rate (1993)

In the standard IAU theory for the orientation of the Earth's equator, the secular obliquity rate arises solely from the motiion of the ecliptic, not from the motion of the equator in space.
Retargeting of natural killer–cell cytolytic activity to ErbB2-expressing cancer cells results in efficient and selective tumor cell destruction (2002)

The continuously growing natural killer (NK) cell line NK-92 is highly cytotoxic against malignant cells of various origins without affecting normal human cells. Based on this selectivity, the potential of NK-92 cells for adoptive therapy is currently being investigated in phase I clinical studies. To further enhance the antitumoral activity of NK-92 cells and expand the range of tumor entities suitable for NK-92-based therapies, here by transduction with a retroviral vector we have generated genetically modified NK-92 cells expressing a chimeric antigen receptor specific for the tumor-associated ErbB2 (HER2/neu) antigen, which is overexpressed by many tumors of epithelial origin. The chimeric antigen receptor consists of the ErbB2-specific scFv(FRP5) antibody fragment, a flexible hinge region derived from CD8, and transmembrane and intracellular regions of the CD3 zeta chain. Transduced NK-92-scFv(FRP5)-zeta cells express high levels of the fusion protein on the cell surface as determined by fluorescence-activated cell-scanning (FACS) analysis. In europium release assays, no difference in cytotoxic activity of NK-92 and NK-92-scFv(FRP5)-zeta cells toward ErbB2-negative targets was found. However, even at low effector-to-target ratios, NK-92-scFv(FRP5)-zeta cells specifically and efficiently lysed established and primary ErbB2-expressing tumor cells that were completely resistant to cytolytic activity of parental NK-92 cells. These results demonstrate that efficient retargeting of NK-92 cytotoxicity can be achieved and might allow the generation of potent cell-based therapeutics for the treatment of ErbB2-expressing malignancies.
Tungsten Oxo Alkylidene Complexes as Initiators for the Stereoregular Polymerization of 2,3-Dicarbomethoxynorbornadiene (2014)

We have employed 2,3-dicarbomethoxynorbornadiene (DCMNBD) as a monomer to explore new tungsten oxo alkylidene complexes as initiators for stereoregular ROMP (ring-opening metathesis polymerization). The initiators include MAP (monoaryloxide pyrrolide) oxo alkylidene complexes with the general formula W(O)(CHCMe2Ph)(Me2Pyr)(OAr) (Me2Pyr = 2,5-dimethylpyrrolide, OAr = an aryloxide) and W(O)(CHCMe2Ph)(OR)2 (OR = an aryloxide or OC(CF3)3), or PPh2Me or CH3CN adducts thereof. We have found that MAP initiators yield cis,syndiotactic-poly(DCMNBD) as a consequence of stereogenic metal control. In contrast, W(O)(CHCMe2Ph)(OR)2(L) initiators (where L = PPh2Me or acetonitrile) are strongly biased toward formation of cis,isotactic structures, while W(O)(CHCMe2Ph)(OR)2 initiators are strongly biased toward formation of cis,syndiotactic structures. Addition of B(C6F5)3 to W(O)(CHCMe2Ph)(Me2Pyr)(OR) species leads to a dramatic increase in the rate of polymerization and to an increase in the cis,syndiotacticity of the polymer (if not already high), while addition of B(C6F5)3 to W(O)(CHCMe2Ph)(OR)2 initiators leads to a dramatic increase in the rate of polymerization and to the formation of highly cis,syndiotactic polymers. All evidence supports the proposal that 16e W(O)(CHCMe2Ph)(OR)2(L) complexes can operate either through loss of L to yield 14e W(O)(CHCMe2Ph)(OR)2 species (which yield largely cis,syndiotactic-poly(DCMNBD)) or by directly reacting with DCMNBD to yield an 18e intermediate and largely cis,isotactic-poly(DCMNBD). All polymerizations by W(O)(CHCMe2Ph)(OR)2(L) and W(O)(CHCMe2Ph)(OR)2 initiators are proposed to operate through some version of chain end control.
Oligonucleotide-Mediated Genome Editing Provides Precision and Function to Engineered Nucleases and Antibiotics in Plants (2016)

Here, we report a form of oligonucleotide-directed mutagenesis for precision genome editing in plants that uses single-stranded oligonucleotides (ssODNs) to precisely and efficiently generate genome edits at DNA strand lesions made by DNA double strand break reagents. Employing a transgene model in Arabidopsis (Arabidopsis thaliana), we obtained a high frequency of precise targeted genome edits when ssODNs were introduced into protoplasts that were pretreated with the glycopeptide antibiotic phleomycin, a nonspecific DNA double strand breaker. Simultaneous delivery of ssODN and a site-specific DNA double strand breaker, either transcription activator-like effector nucleases (TALENs) or clustered, regularly interspaced, short palindromic repeats (CRISPR/Cas9), resulted in a much greater targeted genome-editing frequency compared with treatment with DNA double strand-breaking reagents alone. Using this site-specific approach, we applied the combination of ssODN and CRISPR/Cas9 to develop an herbicide tolerance trait in flax (Linum usitatissimum) by precisely editing the 5'-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE (EPSPS) genes. EPSPS edits occurred at sufficient frequency that we could regenerate whole plants from edited protoplasts without employing selection. These plants were subsequently determined to be tolerant to the herbicide glyphosate in greenhouse spray tests. Progeny (C1) of these plants showed the expected Mendelian segregation of EPSPS edits. Our findings show the enormous potential of using a genome-editing platform for precise, reliable trait development in crop plants.
Quantitative methylation analysis of multiple genes using methylation-sensitive restriction enzyme-based quantitative PCR for the detection of hepatocellular carcinoma (2011)

DNA methylation is a promising biomarker for cancer. This study was aimed at investigating the methylation levels of multiple genes in hepatocellular carcinoma (HCC) and to identify a combination of methylation markers that would be useful for the diagnosis of HCC. The methylation status of a panel of nine tumor-associated genes (APC, GSTP1, RASSF1A, CDKN2A, SFRP1, RUNX3, SOCS1, Hint1, and HIC-1) in 8 normal liver tissues and 47 paired HCCs and non-tumorous tissues (NTs) was determined using a modified methylation-sensitive, restriction enzyme-based quantitative PCR (MSRE-qPCR) method. The methylation levels of six genes (APC, CDKN2A, GSTP1, RASSF1A, SFRP1 and RUNX3) were significantly higher in HCCs than in adjacent NTs (P<0.05). Although the AUC (area under the curve) for each individual gene was low to moderate (range: 0.576 to 0.835) according to receiver operator characteristic (ROC) curve analysis, the combination analysis of these six genes resulted in an increase of AUC of 0.954 with 85.1% sensitivity, 89.4% specificity, 88.9% positive predictive value, and 85.7% negative predictive value in discriminating HCC tissues from NT tissues. These results indicate that the analysis of a combination of these six methylated genes may be a promising method for the risk assessment and diagnosis of HCC.
The Evidence Behind Noninvasive Body Contouring Devices (2015)

The demand for body contouring is rapidly increasing, and interest in noninvasive approaches has also grown. The author reviewed the evidence base behind the currently available devices and methods for nonsurgical body contouring. There is little high-level evidence in the present literature to support the effectiveness of any of these devices.
Turnover of Amyloid β-Protein in Mouse Brain and Acute Reduction of Its Level by Phorbol Ester (1998)

Fibrillar amyloid deposits are defining pathological lesions in Alzheimer's disease brain and are thought to mediate neuronal death. Amyloid is composed primarily of a 39-42 amino acid protein fragment of the amyloid precursor protein (APP), called amyloid beta-protein (Abeta). Because deposition of fibrillar amyloid in vitro has been shown to be highly dependent on Abeta concentration, reducing the proteolytic release of Abeta is an attractive, potentially therapeutic target. Here, the turnover rate of brain Abeta has been determined to define treatment intervals over which a change in steady-state concentration of Abeta could be measured. Mice producing elevated levels of human Abeta were used to determine approximate turnover rates for Abeta and two of its precursors, C99 and APP. The t1/2 for brain Abeta was between 1.0 and 2.5 hr, whereas for C99, immature, and fully glycosylated forms of APP695 the approximate t1/2 values were 3, 3, and 7 hr, respectively. Given the rapid Abeta turnover rate, acute studies were designed using phorbol 12-myristate 13-acetate (PMA), which had been demonstrated previously to reduce Abeta secretion from cells in vitro via induction of protein kinase C (PKC) activity. Six hours after intracortical injection of PMA, Abeta levels were significantly reduced, as measured by both Abeta40- and Abeta42-selective ELISAs, returning to normal by 12 hr. An inactive structural analog of PMA, 4alpha-PMA, had no effect on brain Abeta levels. Among the secreted N-terminal APP fragments, APPbeta levels were significantly reduced by PMA treatment, whereas APPalpha levels were unchanged, in contrast to most cell culture studies. These results indicate that Abeta is rapidly turned over under normal conditions and support the therapeutic potential of elevating PKC activity for reduction of brain Abeta.
Mid-IR focal plane array based on type-II InAs∕GaSb strain layer superlattice detector with nBn design (2008)

A midwave infrared camera (λc=4.2μm) with a 320×256 focal plane array (FPA) based on type-II InAs∕GaSb strain layer superlattice (SLs) has been demonstrated. The detectors consist of an nBn heterostructure, wherein the SL absorber and contact layers are separated by a Al0.2Ga0.8Sb barrier layer, which is designed to have a minimum valence band offset. Unlike a PN junction, the size of the device is not defined by a mesa etch but confined by the lateral diffusion length of minority carriers. At 77K, the FPA demonstrates a temporal noise equivalent temperature difference (NETD) of 23.8mK (Tint=16.3ms and Vb=0.7V) with a peak quantum efficiency and detectivity at 3.8μm equal to 52% and 6.7×1011 Jones, respectively.
Regioselektive Reaktionen an der 17‐Oxogruppe von Androsta‐1,4‐dien‐3,17‐dion nach in‐situ‐Schutz mit Titantetrakis(dimethylamid) (1993)

Regioselective Reactions at the 17‐Oxo Group of Androsta‐1,4‐dine‐3,17‐dione after in situ Protection with Titaniumtetrakis(dimethylamide) After in situ protection of androsta‐1,4‐diene‐3,17‐dione ( 1 ) with titaniumtetrakis(dimethylamide) ( 10 ) at −20°C to −30°C, the lithium enolates of methyl methoxyacetate ( 2a ) and ethyl acetate ( 2b ) react regio‐ and stereoselectively at the 17‐position to give the 17‐hydroxy‐17α‐pregnanes 12 and 6 . Dehydration of 12 and 6 furnishes the 17(20)‐olefins 13 and 14 , intermediates for the synthesis of corticoids and gestagens. The reaction of 1 with 10 and 2a at −60°C gives byproducts of a dienone‐benzene rearrangement of the A‐ring. The reactions of 1 with 2a and 2b without titaniumtetrakis‐(dimethylamide) ( 10 ) proceed regioselectively at the 3‐position or nonregioselectively at the 3‐ and 17‐positions, respectively.