gebhart/patrepeval huggingface dataset:
DD3: a new prostate-specific gene, highly overexpressed in prostate cancer. (1999)

Prostate cancer is the most commonly diagnosed malignancy and the second leading cause of cancer-related deaths in the Western male population. Despite the tremendous efforts that have been made to improve the early detection of this disease and to design new treatment modalities, there is still an urgent need for new markers and therapeutic targets for the management of prostate cancer patients. Using differential display analysis to compare the mRNA expression patterns of normal versus tumor tissue of the human prostate, we identified a cDNA, DD3, which is highly overexpressed in 53 of 56 prostatic tumors in comparison to nonneoplastic prostatic tissue of the same patients. Reverse transcription-PCR analysis using DD3-specific primers indicated that the expression of DD3 is very prostate specific because no product could be amplified in 18 different normal human tissues studied. Also, in a sampling of other tumor types and a large number of cell lines, no expression of DD3 could be detected. Molecular characterization of the DD3 transcription unit revealed that alternative splicing and alternative polyadenylation occur. The fact that no extensive open reading frame could be found suggests that DD3 may function as a noncoding RNA. The DD3 gene was mapped to chromosome 9q21-22, and no homology of DD3 to any gene present in the computer databases was found. Our data indicate that DD3 is one of the most prostate cancer-specific genes yet described, and this makes DD3 a promising marker for the early diagnosis of prostate cancer and provides a powerful tool for the development of new treatment strategies for prostate cancer patients.
Mechanisms of Wave Fractionation at Boundaries of High-Frequency Excitation in the Posterior Left Atrium of the Isolated Sheep Heart During Atrial Fibrillation (2006)

During stable AF, the PLA harbors regular, fast, and highly organized activity; the outer limit of the DFmax domain is the area where the most propagation pattern variability and fractionated activity occur. These new concepts introduce a new perspective in the clinical use of high-frequency fractionated electrograms to localize sources of AF precisely at the PLA and elsewhere.
Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 (2016)

Osteoarthritis is a common debilitating joint disorder. Risk factors for osteoarthritis include age, which is associated with thinning of articular cartilage. Here we generate chondrocyte-specific salt-inducible kinase 3 (Sik3) conditional knockout mice that are resistant to osteoarthritis with thickened articular cartilage owing to a larger chondrocyte population. We also identify an edible Pteridium aquilinum compound, pterosin B, as a Sik3 pathway inhibitor. We show that either Sik3 deletion or intraarticular injection of mice with pterosin B inhibits chondrocyte hypertrophy and protects cartilage from osteoarthritis. Collectively, our results suggest Sik3 regulates the homeostasis of articular cartilage and is a target for the treatment of osteoarthritis, with pterosin B as a candidate therapeutic.
A Working Research Prototype of an ISDN Central Office (1986)

This paper describes a working research prototype of an ISDN central office which demonstrates the key hardware and software elements needed for ISDN services. As such, it does not include all the normal trappings of a central office such as maintenance or non-ISDN interfaces and there is no attempt to cope with heavy traffic conditions. Details are included on the prototype central office architecture which is a distributed system, the call processing procedure's and the necessary data structures which provide basic circuit switching and a small number of advanced capabilities. These include the ability to suspend and resume calls at different line appearances, the ability of users to set their own line restrictions and move their services from one line to another, and the allowance of multiple directory number listings for terminals. Also discussed are security aspects of such line controls and commonplace call scenarios which must be considered to avoid deadlocks or incorrect processing by the call processor. Detailed presentations consider all of these aspects within the context of a real-time distributed central office software architecture.
Finite element modeling of laser-based thermoelastic ultrasound generation (2003)

Using a scanned laser to generate ultrasound, via the thermoelastic effect, offers an alternative approach for realizing high density, high frequency ultrasound imaging arrays. The approach bypasses the complexity and intricacy required for forming conventional piezoelectric array elements and their associated electrical connections. Thus, it is particularly well suited to 2D arrays. In this paper, the devices considered comprise a carbon black loaded PDMS polymer layer on top of a glass or PDMS substrate. PZFlex Finite Element Analysis (FEA) was used to investigate the impact of a variety of design variables including: laser spot size, substrate material and thermoelastic coupling medium. Predicted single element angular response broadly matched responses obtained by experiment. Specifically, if a low acoustic loss glass substrate is used then measurable sidelobes occur at approximately 40 degrees. However, if the glass substrate is replaced by a PDMS material, then the traveling waves that give rise to sidelobes are no longer supported and a smooth single element angular response is obtained in both experiment and FEA simulation. FEA suggests that there are other modes in addition to the Rayleigh mode observed in the experiment. It is believed that these modes are more quickly damped in the experimental case. Therefore, while FEA provides a very versatile and valuable analysis tool, the accuracy of its predictions are contingent on accurate knowledge of device geometry and relevant material properties.
Antigen processing mutant T2 cells present viral antigen restricted through H‐2K (1993)

Cytotoxic T lymphocytes (CTL) recognize foreign antigens as short peptides presented by class I molecules of the major histocompatibility complex (MHC). T2 cells are profoundly defective in the presentation of endogenously synthesized antigens to CTL due to a deletion of MHC class II-encoded genes for transporters associated with antigen presentation (TAP1/TAP2). Surprisingly, we here demonstrate that T2 cells, after infection with Sendai virus, are readily killed by H-2Kb restricted CD8+ T cells. In contrast to classical class I-mediated antigen presentation, the presentation of Sendai virus antigen in T2Kb cells is brefeldin A (BFA) insensitive. The present findings may suggest the presence of an alternative pathway for MHC class I-mediated antigen presentation in T2 cells.
Requirements for incorporation of Pr160gag-pol from human immunodeficiency virus type 1 into virus-like particles (1993)

The roles of the human immunodeficiency virus precursor polyproteins Pr55gag and Pr160gag-pol in viral core assembly were studied in CMT3-COS cells. To do this, the precursors were expressed separately by using a simian virus 40 late replacement vector system described previously. Consistent with previously published data, our results show that the Pr55gag precursor, when expressed alone, was able to form particles which had an immature morphology and that particle formation required the presence of a myristate addition signal at the amino terminus of the precursor. In contrast, the Pr160gag-pol precursor was not able to form particles when expressed alone, although it still underwent proteolytic processing. Coexpression of the two precursor polyproteins from separate vectors in the same cell resulted in processing of the Pr55gag in trans by the protease embedded in Pr160gag-pol and the formation of virus-like particles containing the products of both precursors. Proteolytic processing occurred independently of the presence of a functional myristate addition signal on either precursor. On the other hand, removal of myristate from one or the other precursor had nonreciprocal effects on virus particle formation. Cells expressing Pr55gag lacking myristate and Pr160gag-pol containing it did not produce particles. Cells expressing a myristylated Pr55gag and unmyristylated Pr160gag-pol still produced virus-like particles which contained nearly normal amounts of Pr160gag-pol. The results suggest that the incorporation of Pr160gag-pol into particles is largely determined by intermolecular protein-protein interactions between the two precursor polypeptides.
A rapid and convenient synthesis of poly-thymidylic acid by the modified triester approach (1977)

By using anhydrous triethylamine-pyridine to selectively remove the cyanoethyl group from the fully protected oligonucleotide, a substantial improvement has been achieved in yields and the rates of condensation by the modified triester approach from the 5' leads to 3' end. The unreacted oligonucleotide containing the 5'-hydroxy group was removed by treatment with bis (triazolyl)-p-chlorophenyl phosphate after each condensation in situ. These modifications, as exemplified by the synthesis of fully protected T12, T18, T24 and T38 in 80%, 77%, 70% and 50% yields respectively, should allow the ready synthesis of polynucleotides of even longer chain lengths by purely chemical methods.
Printed Assemblies of Inorganic Light-Emitting Diodes for Deformable and Semitransparent Displays (2009)

We have developed methods for creating microscale inorganic light-emitting diodes (LEDs) and for assembling and interconnecting them into unusual display and lighting systems. The LEDs use specialized epitaxial semiconductor layers that allow delineation and release of large collections of ultrathin devices. Diverse shapes are possible, with dimensions from micrometers to millimeters, in either flat or "wavy" configurations. Printing-based assembly methods can deposit these devices on substrates of glass, plastic, or rubber, in arbitrary spatial layouts and over areas that can be much larger than those of the growth wafer. The thin geometries of these LEDs enable them to be interconnected by conventional planar processing techniques. Displays, lighting elements, and related systems formed in this manner can offer interesting mechanical and optical properties.
Extraction of lipids from cottonseed tissue: IV. Use of hexane‐acetic acid (1974)

Abstract Hexane and mixtures of hexane and 2–25% acetic acid (v/v) were used to prepare oil and protein from glanded cottonseed by solvent extraction. As the amount of acetic acid in the solvent increased, the amounts of total lipid, phospholipid, neutral oil, and gossypol in each miscella increased, but the amount of free fatty acids did not change significantly. However, the solubility of protein in 0.02N NaOH decreased as the amount of acetic acid in the solvent used to prepare each meal increased. Other aspects of using acidified hexane are described.
Efficient Code Certification (1998)

We introduce a simple and efficient approach to the certification of compiled code. We ensure a basic but nontrivial level of code safety, including control flow safety, memory safety, and stack safety. The system is designed to be simple, efficient, and (most importantly) relatively painless to incorporate into existing compilers. Although less expressive than the proof carrying code of Necula and Lee or typed assembly language of Morrisett et al., our certificates are compact and relatively easy to produce and to verify. Unlike JAVA bytecode, our system operates at the level of native code; it is not interpreted and no further compilation is necessary. 1 Introduction An exciting recent development in program verification is the notion of certified code. When downloading executable code from an untrusted foreign source, a client also downloads a certificate that is checked before running the code to ensure that it is safe to run locally. The certificate is produced by the supplier ...
Human Procathepsin B Interacts with the Annexin II Tetramer on the Surface of Tumor Cells (2000)

To study potential roles of plasma membrane-associated extracellular cathepsin B in tumor cell invasion and metastasis, we used the yeast two-hybrid system to screen for proteins that interact with human procathepsin B. The annexin II light chain (p11), one of the two subunits of the annexin II tetramer, was one of the proteins identified. We have confirmed that recombinant human procathepsin B interacts with p11 as well as with the annexin II tetramer in vitro. Furthermore, procathepsin B could interact with the annexin II tetramer in vivo as demonstrated by coimmunoprecipitation. Cathepsin B and the annexin II tetramer were shown by immunofluorescent staining to colocalize on the surface of human breast carcinoma and glioma cells. Taken together, our results indicate that the annexin II tetramer can serve as a binding protein for procathepsin B on the surface of tumor cells, an interaction that may facilitate tumor invasion and metastasis.
Analysis and Design of Moderate Length Regular LDPC Codes with Low Error Floors (2006)

The traditional method to estimate code performance in the higher SNR region is to use a sum of the contributions of the most dominant error events to the probability of error. If an ML decoder is used, these events will be minimum distance codewords; the traditional decoder used in LDPC codes, some variant of the message passing algorithm, will introduce non-codeword error events known as trapping sets. For long LDPC codes it is difficult to enumerate all of these dominant error events. A procedure to efficiently find dominant error events by using the regular low-density structure of an LDPC code is presented here. The search method can be adapted to work with LDPC codes of various regular and irregular degree distributions, but is especially suited to a very practical subset of LDPC known as regular {3, 6} codes of moderate block length. We also show how codes with very low error floors can be created by utilizing this search method.
Photometric calibration of zoom lens systems (1996)

This paper describes a calibration method of zoom lens systems to eliminate the photometric distortion due to vignetting. A novel camera model including the variable cone is proposed to account for the marginal intensity reduction observed in images. Using the theoretical model, we first show that the serious distortion due to vignetting appears when using a zoom lens that has open aperture and long focal length. Then we present the calibration method to estimate the intensity reduction from the lens parameters of zoom and iris. The experimental results demonstrate the validity of our theoretical model and the effectiveness of the photometric calibration of zoom lens systems.
Pathophysiology of Erectile Dysfunction (1999)

Physiology of erection and pathophysiology erectile dysfunction is reviewed. Analysis is obtained from basic and clinical research including animals studies, anatomical studies, and molecular and cellular research on corporal tissue obtained during penile prosthesis implantation. Supraspinal influences and spinal influence on penile erection has been learned from spinal cord injury patient. Corporal smooth muscle relaxation of penile arteries and corpus cavernosum leads to penile erection, results from parasympathetic/nonadrenergic noncholinergic neural pathway activation and simultaneous inhibition of sympathetic outflow. Anatomical studies taught understanding of the mechanism for restriction of blood outflow from the corpora cavernosa. The change of smooth muscle tone has emerged as a key factor in erection and detumescence. Many independent factors converge on the modulation of corporal smooth muscle tone. Neuronal and local neurotransmitter effects via gap junction, potassium channels, and calcium channel. A nitric oxide/cyclic guanosine monophosphate mechanism as well as cyclic aminomonophosphate has an important role in mediating the corporal smooth muscle relaxation necessary for erectile function. Erectile dysfunction can be due to vasculogenic, neurogenic, hormonal, veno-occlusive, psychogenic and/or pharmacogenic factors as well as alterations in the nitric oxide/cyclic guanosine monophosphate (cGMP) or cyclic aminophosphate (cAMP) pathway or other regulatory mechanisms including gap junction or ionic channel resulting in an imbalance in corporal smooth muscle contraction and relaxation. Our present knowledge of the hemodynamics, functional anatomy, neurophysiology, and neuropharmacology of penile erection and dysfunction at the cellular and molecular level has led to better understanding of physiology and pathophysiology of erectile dysfunction.
Solvent‐Free Synthesis of Cyanoformamides from Carbamoyl Imidazoles (2017)

A straightforward and solvent‐free synthesis of various secondary and tertiary cyanoformamides from carbamoyl imidazoles and TMSCN has been developed. Both cyclic and acyclic carbamoyl imidazoles react smoothly to form the relevant cyanoformamides in excellent yields, often within minutes.
Parstatin: a cryptic peptide involved in cardioprotection after ischaemia and reperfusion injury (2009)

A single treatment of parstatin administered prior to ischaemia confers immediate cardioprotection by recruiting the Gi-protein activation pathway including p38 MAPK, ERK1/2, NOS, and K(ATP) channels. Parstatin exerts effects on both the cardiomyocytes and the coronary circulation to induce cardioprotection. This suggests a potential therapeutic role of parstatin in the treatment of cardiac injury resulting from ischaemia and reperfusion.
An Innovative Technique for Recording Picture‐in‐Picture Ultrasound Videos (2013)

Many ultrasound educational products and ultrasound researchers present diagnostic and interventional ultrasound information using picture-in-picture videos, which simultaneously show the ultrasound image and transducer and patient positions. Traditional techniques for creating picture-in-picture videos are expensive, nonportable, or time-consuming. This article describes an inexpensive, simple, and portable way of creating picture-in-picture ultrasound videos. This technique uses a laptop computer with a video capture device to acquire the ultrasound feed. Simultaneously, a webcam captures a live video feed of the transducer and patient position and live audio. Both sources are streamed onto the computer screen and recorded by screen capture software. This technique makes the process of recording picture-in-picture ultrasound videos more accessible for ultrasound educators and researchers for use in their presentations or publications.
Projection Photolithography (2000)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text MASUD MANSURIPUR and RONGGUANG LIANG, "Projection Photolithography," Optics & Photonics News 11(2), 36-40 (2000) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Adipose-Derived Stem Cells Are a Source for Cell Therapy of the Corneal Stroma (2007)

Most corneal diseases affect corneal stroma and include immune or infectious diseases, ecstatic disorders, traumatic scars, and corneal dystrophies. Cell-based therapy is a promising therapeutic approach to overcome the current disadvantages of corneal transplantation. We intended to search for a cell source to repopulate and regenerate corneal stroma. We investigated the ability of human processed lipoaspirate derived (PLA) cells to regenerate corneal stroma in experimental animals. In the first set of experiments, we tested the biosafety and immunogenicity of human PLA stem cells transplanted into the corneal stroma of rabbits. No immune response was elicited even though we used immune-competent animals. PLA cells survived up to 10 weeks post-transplant, maintained their shape, and remained intermingled in the stroma without disrupting its histological pattern. Interestingly, transparency was preserved even 10 weeks after the transplant, when PLA cells formed a discontinuous layer in the stroma. In the second set of experiments, regeneration of the corneal stroma by PLA cells was assessed, creating a niche by partial ablation of the stroma. After 12 weeks, human cells were disposed following a multilayered pattern and differentiated into functional keratocytes, as assessed by the expression of aldehyde-3-dehydrogenase and cornea-specific proteoglycan keratocan. Based on our results, we believe that adipose-derived adult stem cells can be a cell source for stromal regeneration and repopulation in diseased corneas. The low health impact of the surgical procedure performed to obtain the PLA cells provides this cell source with an additional beneficial feature for its possible future autologous use in human patients.
Vocal fold paresis: evidence and controversies (2007)

Vocal fold paresis is probably a significant source of vocal disability, especially among cases that have eluded straightforward diagnosis. An accurate assessment of its clinical impact, patterns of dysfunction, natural history and relationship to other pathologies depends on diagnostic rigor and accuracy and is still evolving.
Synthesis of Potential Anticancer Agents. XXIII. 9-Aminohypoxanthine and Related Compounds (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Potential Anticancer Agents. XXIII. 9-Aminohypoxanthine and Related CompoundsJohn A. Montgomery and Carroll Temple Jr.Cite this: J. Am. Chem. Soc. 1960, 82, 17, 4592–4596Publication Date (Print):September 1, 1960Publication History Published online1 May 2002Published inissue 1 September 1960https://pubs.acs.org/doi/10.1021/ja01502a037https://doi.org/10.1021/ja01502a037research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts