gebhart/patrepeval huggingface dataset:
<title>Deposition of oxide thin films on silicon using organic self-assembled monolayers</title> (1996)

Crystalline oxide thin films have been synthesized at low temperatures from aqueous liquid solutions. A key element of the approach is the use of organic self-assembled monolayers (SAMs) on the substrate to promote the growth of adherent inorganic films. A SAM is a close- packed, highly ordered array of long-chain hydrocarbon molecules, anchored to the substrate by covalent bonds. The terminating functional group on the SAM surface is chosen so as to initiate and help sustain the formation of the oxide film when the substrate is immersed in the oxide precursor solution. Synthesis, microstructural characterization, and properties of TiO<SUB>2</SUB>, ZrO<SUB>2</SUB>, SiO<SUB>2</SUB>, and Y<SUB>2</SUB>O<SUB>3</SUB> films are surveyed. Crystalline films were formed either directly from solution, or through subsequent heat treatments at temperatures that in most cases were lower than typical sol-gel or vapor phase deposition processes. All depositions were from aqueous solutions onto single-crystal (100) silicon. The ability to produce patterned films on a micron scale has been demonstrated, taking advantage of the selective deposition characteristics towards different surface functional groups of the SAM. The role of the SAM in oxide film formation is discussed.
Excess Loop Delay Compensation in Continuous-Time Delta-Sigma Modulators (2008)

We present a simple, intuitive technique to compensate the loop filter transfer function for excess delay in low-pass continuous-time DeltaSigma modulators. Conventional methods of finding the appropriate filter coefficients to account for loop delay work in the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">z</i> -domain, leading to cumbersome algebra. We show that the same objective can be accomplished entirely in the continuous-time domain, resulting in a procedure that lends itself to hand calculations, even for high order modulators. We derive closed-form expressions for the loop filter coefficients in modulators using nonreturn-to-zero and return-to-zero digital-to-analog converters. Simulation results confirming the theory are given.
Experimental and theoretical study of Penning ionisation of H2O by metastable helium He(23S) (1985)

Combining experimental and theoretical information the authors develop a model for Penning ionisation of H2O by He(23S): the population ratio of the different ionic states depends on the orientation of H2O with respect to He*. A strong anisotropy of the He*+H2O energy surface makes this effect visible in the experimental electron energy spectrum.
An 84 pW/Frame Per Pixel Current-Mode CMOS Image Sensor With Energy Harvesting Capability (2011)

In this paper, we present an ultra-low-power current-mode image sensor with energy harvesting capability. By biasing the in-pixel transconductance amplifier in triode region and using a pipelined 9-bit current-mode analog-to-digital converter (ADC), a power consumption as low as 84 pW/frame per pixel is achieved. Besides the ultra-low-power feature, the proposed 6T pixel can also be used as a solar cell by reconfiguring the in-pixel P+/Nwell photodiode, which can generate several micro watt power at Klux illumination levels. As a result, this energy harvesting imager is very suitable for wireless image sensor network applications. The test chip with a 128 × 96 pixel array resolution is fabricated using a 0.35 μ m CMOS technology. The random noise and the fixed pattern noise (FPN) in dark are 0.4% and 1%, respectively. In the energy harvesting mode, 4.85 μW power can be harvested using the reconfigurable pixel array.
Characterization of a cDNA for human protein C inhibitor. A new member of the plasma serine protease inhibitor superfamily. (1987)

A cDNA library in lambda-phage lambda gt11 containing DNA inserts prepared from human liver mRNA was screened with monoclonal antibodies to human protein C inhibitor. Six positive clones were isolated from 6 X 10(6) phages and plaque purified. The cDNA in the phage containing the largest insert, which hybridized to a DNA probe prepared on the basis of the amino-terminal amino acid sequence of the mature inhibitor, was sequenced. This cDNA insert contained 2106 base pairs coding for a 5'-noncoding region, a 19-amino acid signal peptide, a 387-amino acid mature protein, a stop codon, and a long 3'-noncoding region of 839 base pairs. Based on the amino acid sequence of the carboxyl-terminal peptide released by cleavage of protein C inhibitor by activated protein C as well as by thrombin, the reactive site peptide bond of protein C inhibitor is Arg354-Ser355. Five potential carbohydrate-binding sites were found in the mature protein. The high homology of the amino acid sequence of protein C inhibitor to the other known inhibitors clearly demonstrates that protein C inhibitor is a member of the superfamily of serine protease inhibitors including alpha 1-antichymotrypsin, alpha 1-antitrypsin, antithrombin III, ovalbumin, and angiotensinogen. Based on the difference matrices for these proteins, we present possible phylogenetic trees for these proteins.
<title>Retrieval by content in symbolic-image databases</title> (1996)

Two approaches for integrating images into the framework of a database management system are presented. The classification approach preprocesses all images and attaches a semantic classification and an associated certainty factor to each object found in the image. The abstraction approach describes each object in the image by using a vector consisting of the values of some of its features (e.g., shape, genus, etc.). The approaches differ in the way in which responses to queries that are based on image content are computed. In the classification approach, images are retrieved on the basis of whether or not they contain objects that have the same classification as query objects. In the abstraction approach, retrieval is on the basis of similarity of feature vector values of these objects. Both the pattern recognition and indexing aspects of the method are addressed for each approach. The emphasis is on extracting both contextual and spatial information from the raw images. Methods for storing and indexing symbolic images as tuples in a relation are presented for each approach. Indices are constructed for both the contextual and the spatial data. The user interface for a pictorial information system based on these two approaches is also presented.
Detection of Hydroxyl Ions in Bone Mineral by Solid-State NMR Spectroscopy (2003)

Previous measurements of the hydroxyl (OH-) ion content of the calcium phosphate crystals of bone mineral have indicated a substantial depletion or near-absence of OH-, despite its presumed status as a constituent of the hydroxyapatite lattice. Analytical methods for determining bone crystal OH- content have depended on procedures or assumptions that may have biased the results, such as chemical pretreatment to eliminate interference from the organic matrix. We demonstrate a two-dimensional solid-state nuclear magnetic resonance (NMR) spectroscopy technique that detects the proton spectrum of bone crystals while suppressing the interfering matrix signals, eliminating the need for specimen pretreatment other than cryogenic grinding. Results on fresh-frozen and ground whole bone of several mammalian species show that the bone crystal OH- is readily detectable; a rough estimate yields an OH- content of human cortical bone of about 20% of the amount expected in stoichiometric hydroxyapatite. This finding sheds light on the biochemical processes underlying normal and abnormal bone mineral metabolism.
Development of novel separation techniques for biological samples in capillary electrophoresis (1994)

This dissertation includes three different topics: general introduction of capillary electrophoresis (CE); gradient in CE and CE in biological separations; and capillary gel electrophoresis (CGE) for DNA separation. Factors such as temperature, viscosity, pH, and the surface of capillary walls affecting the separation performance are demonstrated. A pH gradient between 3.0 and 5.2 is useful to improve the resolution among eight different organic acids. A flow gradient due to the change in the concentration of surfactant, which is able to coat to the capillary wall to change the flow rate and its direction, is also shown as a good way to improve the resolution for organic compounds. A temperature gradient caused by joule heat is shown by voltage programming to enhance the resolution and shorten the separation time for several phenolic compounds. The author also shows that self-regulating dynamic control of electroosmotic flow in CE by simply running separation in different concentrations of surfactant has less matrix effect on the separation performance. One of the most important demonstrations in this dissertation is that the author proposes on-column reaction which gives several advantages including the use of a small amount of sample, low risk of contamination, and time saving and kinetic features. The author uses this idea with laser induced fluorescence (LIF) as a detection mode to detect an on-column digestion of sub-ng of protein. This technique also is applied to single cell analysis in the group.
Independent prognostic importance of microvessel density in clinically localized prostate cancer. (2001)

Assessment of MVD in moderately differentiated prostatic adenocarcinomas may improve the prognostic stratification of patients after radical prostatectomy.
Asia - The political economy of agricultural pricing policy : volume 2 (1991)

This report summarizes the results of an agricultural study in Asia. The project employed a common analytical framework and entailed close collaboration between the investigators and the project's three codirectors. This volume deals with six countries in Asia: Korea, Malaysia, Pakistan, Philippines, Sri Lanka, and Thailand. The purpose of the project was threefold: to provide systematic estimates of the degree of price discrimination against agriculture within individual countries and to explain how it changed over time; to determine how this intervention affected such key variables as foreign exchange earnings, agricultural output, and income distribution; and to gain further insight into the political economy of agricultural pricing policy through a study of the motivations of policymakers, the economic and political factors determining the degree of agricultural intervention, and the attempts to reform unsuccessful policies.
Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence (2013)

Blood flow plays crucial roles in vascular development, remodeling and homeostasis, but the molecular pathways required for transducing flow signals are not well understood. In zebrafish embryos, arterial expression of activin receptor-like kinase 1 (alk1), which encodes a TGFβ family type I receptor, is dependent on blood flow, and loss of alk1 mimics lack of blood flow in terms of dysregulation of a subset of flow-responsive arterial genes and increased arterial endothelial cell number. These data suggest that blood flow activates Alk1 signaling to promote a flow-responsive gene expression program that limits nascent arterial caliber. Here, we demonstrate that restoration of endothelial alk1 expression to flow-deprived arteries fails to rescue Alk1 activity or normalize arterial endothelial cell gene expression or number, implying that blood flow may play an additional role in Alk1 signaling independent of alk1 induction. To this end, we define cardiac-derived Bmp10 as the crucial ligand for endothelial Alk1 in embryonic vascular development, and provide evidence that circulating Bmp10 acts through endothelial Alk1 to limit endothelial cell number in and thereby stabilize the caliber of nascent arteries. Thus, blood flow promotes Alk1 activity by concomitantly inducing alk1 expression and distributing Bmp10, thereby reinforcing this signaling pathway, which functions to limit arterial caliber at the onset of flow. Because mutations in ALK1 cause arteriovenous malformations (AVMs), our findings suggest that an impaired flow response initiates AVM development.
Silver triflate-catalysed synthesis of γ-lactones from fatty acids (2009)

A silver(I)-based catalytic system was found to efficiently promote the double-bond isomerization of unsaturated fatty acids and at the same time to mediate the intramolecular addition of the carboxylate group to the isomerized double bond under selective formation of five-ring lactones. The resulting one-step isomerization–γ-lactonization process allows the direct conversion of unsaturated fatty acids into the corresponding γ-lactones in good yields.
Universal back-projection algorithm for photoacoustic computed tomography (2005)

We report results of a reconstruction algorithm for three-dimensional photoacoustic computed tomography. A universal back-projection formula is presented for three types of imaging geometries: planar, spherical, and cylindrical surfaces. A solid-angle weighting factor is introduced in the back-projection formula to compensate for the variations of detection views. A method for implementing this algorithm is described. Numerical simulation is used to demonstrate the performance of the algorithm.
Human neutrophil bactericidal/permeability-increasing protein reduces mortality rate from endotoxin challenge (1994)

Bactericidal/permeability-increasing protein is a potent antiendotoxin that neutralizes endotoxin in vivo and prevents mortality in animal models of lethal endotoxemia.
Ser/Thr Protein Phosphatase Type 5 (PP5) Is a Negative Regulator of Glucocorticoid Receptor-Mediated Growth Arrest (1999)

Ligand-induced glucocorticoid receptor (GR) activation has recently been linked to the inhibition of cell proliferation via the transcriptional induction of p21(WAF1/Cip1), which functions as a universal inhibitor of cyclin-dependent protein kinases. Herein, we identify a Ser/Thr protein phosphatase (PP5) that promotes cellular proliferation by inhibiting both glucocorticoid and p53-mediated signaling pathways leading to p21(WAF1/Cip1)-mediated growth arrest. The suppression of PP5 expression (1) markedly increases the association of GR with its cognate DNA-binding sequence, (2) induces GR transcriptional activity without the addition of hormone, and (3) increases dexamethasone-mediated induction of GR reporter activity to a level that is approximately 10 times greater than the maximal response obtainable in the presence of PP5. PP5 has no apparent effect on the binding of hormone to the GR, and dexamethasone-mediated growth arrest correlates with an increase in p53 phosphorylation. Comparative studies in p53-wild-type, p53-defective, and p53-deficient cell lines indicate that either (1) p53 participates in GR-mediated induction of p21(WAF1/Cip1), with the hyperphosphorylation of basal p53 induced by glucocorticoids sufficient for the propagation of an antiproliferative response when PP5 expression is inhibited, or (2) PP5 acts where p53-mediated and GR-induced signaling networks converge to regulate the transcriptional induction of p21(WAF1/Cip1). Thus, aberrant PP5 expression may have an additive effect on the development of human cancers by promoting cell proliferation via the inhibition of a GR-induced antiproliferative signaling cascade, and facilitating neoplastic transformation via the inhibition of a growth-arresting p53-mediated response that guards against genomic instability.
The Metabolism of 19-Hydroxycorticosterone: Isolation and Characterization of Three Metabolites (1961)

Formation of deoxyuridine phosphates from different uridine phosphates
A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire. (1994)

Previously, six T cell clones, which are specific for an encephalitogenic determinant of myelin proteolipid protein (PLP) peptide residues 139 to 151 (HSLGKWLGHPDKF), were derived from SJL mice and shown to use diverse TCR genes. To design TCR antagonist peptides that could interfere with the activation of these clones in vitro and inhibit experimental allergic encephalomyelitis (EAE) in vivo, we first determined the TCR and MHC contact residues of the encephalitogenic peptide. The analysis indicated that residues 144 (tryptophan) and 147 (histidine) were the TCR binding sites and that residues 145 (leucine) and 148 (proline) were important for MHC class II (IAs) binding. On the basis of this information, a peptide analogue (leucine 144/arginine 147), in which both of the major TCR contact residues were substituted, was synthesized. This analogue acts as a TCR antagonist for the panel of PLP 139-151-specific T cell clones, does not cause EAE by itself, blocks the induction of disease by the native 139-151 peptide, and prevents clinical disease progression if administered at the first signs of disease. Thus, although multiple TCR genes are used by PLP 139-151-specific clones, a single peptide analogue can interfere with the disease process. This approach should be feasible for designing peptide analogues that can be tested for therapeutic efficacy in human autoimmune diseases in which the pathogenic Ags are known and TCR use is diverse.
Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus (2008)

Proteolysis of mutant huntingtin is crucial to the development of Huntington disease (HD). Specifically preventing proteolysis at the capase-6 (C6) consensus sequence at amino acid 586 of mutant huntingtin prevents the development of behavioural, motor and neuropathological features in a mouse model of HD. However, the mechanism underlying the selective toxicity of the 586 amino acid cleavage event is currently unknown. We have examined the subcellular localization of different caspase proteolytic fragments of huntingtin using neo-epitope antibodies. Our data suggest that the nucleus is the primary site of htt cleavage at amino acid 586. Endogenously cleaved 586 amino acid fragments are enriched in the nucleus of immortalized striatal cells and primary striatal neurons where they co-localize with active C6. Cell stress induced by staurosporine results in the nuclear translocation and activation of C6 and an increase in 586 amino acid fragments of huntingtin in the nucleus. In comparison, endogenous caspase-2/3-generated huntingtin 552 amino acid fragments localize to the perinuclear region. The different cellular itineraries of endogenously generated caspase products of huntingtin may provide an explanation for the selective toxicity of huntingtin fragments cleaved at amino acid 586.
Effect of Point Imperfections on Lattice Thermal Conductivity (1960)

The consequences of a simple, phenomenological, theory of lattice thermal conductivity with respect to the effect of point imperfections are summarized. The experimental results of Berman et al. on the effect of varying the concentration of ${\mathrm{Li}}^{6}$ on the conductivity of lithium fluoride are analyzed in detail.
Potential role of chitinase 3-like-1 in inﬂammationassociated carcinogenic changes of epithelial cells (2009)

The family of mammalian chitinases includes members both with and without glycohydrolase enzymatic activity against chitin, a polymer of N-acetylglucosamine. Chitin is the structural component of fungi, crustaceans, insects and parasitic nematodes, but is completely absent in mammals. Exposure to antigens containing chitin- or chitin-like structures sometimes induces strong T helper type-I responses in mammals, which may be associated with the induction of mammalian chitinases. Chitinase 3-like-1 (CHI3L1), a member of the mammalian chitinase family, is induced specifically during the course of inflammation in such disorders as inflammatory bowel disease, hepatitis and asthma. In addition, CHI3L1 is expressed and secreted by several types of solid tumors including glioblastoma, colon cancer, breast cancer and malignant melanoma. Although the exact function of CHI3L1 in inflammation and cancer is still largely unknown, CHI3L1 plays a pivotal role in exacerbating the inflammatory processes and in promoting angiogenesis and remodeling of the extracellular matrix. CHI3L1 may be highly involved in the chronic engagement of inflammation which potentiates development of epithelial tumorigenesis presumably by activating the mitogen-activated protein kinase and the protein kinase B signaling pathways. Anti-CHI3L1 antibodies or pan-chitinase inhibitors may have the potential to suppress CHI3L1-mediated chronic inflammation and the subsequent carcinogenic change in epithelial cells.
End-to-End Memory Networks with Knowledge Carryover for Multi-Turn Spoken Language Understanding (2016)

Spoken language understanding (SLU) is a core component of a spoken dialogue system. In the traditional architecture of dialogue systems, the SLU component treats each utterance independent of each other, and then the following components aggregate the multi-turn information in the separate phases. However, there are two challenges: 1) errors from previous turns may be propagated and then degrade the performance of the current turn; 2) knowledge mentioned in the long history may not be carried into the current turn. This paper addresses the above issues by proposing an architecture using end-to-end memory networks to model knowledge carryover in multi-turn conversations, where utterances encoded with intents and slots can be stored as embeddings in the memory and the decoding phase applies an attention model to leverage previously stored semantics for intent prediction and slot tagging simultaneously. The experiments on Microsoft Cortana conversational data show that the proposed memory network architecture can effectively extract salient semantics for modeling knowledge carryover in the multi-turn conversations and outperform the results using the state-of-the-art recurrent neural network framework (RNN) designed for single-turn SLU.