gebhart/patrepeval huggingface dataset:
Microbiological studies on the in vitro inhibitory effect of Streptomyces collinus albescens against some phytopathogenic fungi (2012)

This study was carried out with the isolation of Streptomyces bacteria from soil samples of Dilam city. Seventy two (72) Streptomyces isolates were isolated and purified using starch nitrate agar medium. On the other hand, nine (9) phytopathogenic fungi were isolated from rotted roots of six different plants, namely Triticum aestivum (wheat),Trifolium trifolium (clover), Coriandrum sativum (coriander), Cucurbita pepo (zucchini),Cucumis sativus (cucumber) and Avena sativa (oat). These fungi were primarily identified as Fusarium spw (from diseased wheat), Fusarium spc and Macrophamina spc (from diseased clover), Fusarium spco, Macrophamina spco and Rhizoctonia spco (from diseased coriander), Fusarium spz (from diseased zucchini), Fusarium spcu (from diseased cucumber) and Fusarium spo (from diseased oat). Screening test was done for all Streptomyces isolates against phytopathogenic fungi to determine the antifungal activity. The antifungal activity was shown at 24 Streptomyces isolates by various efficacies. However, Streptomyces isolate number 13 (S-13) has the highest antifungal activity especially against 6 fungi, Fusarium spw, Fusarium spc, Macrophamina spc,Macrophamina spco, Rhizoctonia spco and Fusarium spcu. The isolate S-13 was identified as Streptomyces collinus albescens by using gene for 16S rRNA which was firstly recorded in gene bank with accession number AB184101.2. Optimum factors were studied to obtain the maximum yield of antifungal compound. The 5th day has the best incubation period, 30°C is a best incubation temperature, 7.5 is a best pH value, with glucose and ammonium nitrate as the best carbon and nitrogen source, respectively.

	 

	Key words: Antifungal activity, Fusarium sp, Macrophamina sp, Rhizoctonia sp, 16S rRNA
Use of Nonsteroidal Anti-inflammatory Drugs and Incidence of Colorectal Cancer (1999)

In this elderly population, long-term use of nonaspirin NSAIDs nearly halved the risk of colon cancer. This study was consistent with previous studies that suggest that duration of use but not daily dose of NSAIDs is an important factor for chemoprevention. Our data also suggest that the protective effect is shared by most NSAIDs, and not confined to a small number of these drugs.
New Class of Ultrathin, Highly Cell-Adhesion-Resistant Polyelectrolyte Multilayers with Micropatterning Capabilities (2003)

Hydrogen-bonded multilayers comprised of polyacrylamide (PAAm) and a weak polyelectrolyte, such as poly(acrylic acid) (PAA) or poly(methacrylic acid) (PMA), were investigated for their surface-cell interactions. The assembled films were lightly cross-linked thermally or photochemically in order to render them stable in a physiological environment. Both PAA/PAAm and PMA/PAAm multilayers were found to exhibit a high resistance to the adhesion (cytophobicity) of mammalian fibroblasts, even with only a single bilayer coating. Protein adsorption to the multilayers, as revealed by surface plasmon resonance measurements, was greatly reduced for fibronectin and serum-containing medium. In situ swelling experiments indicate that the H-bonded multilayers are hydrogellike coatings capable of a high level of swelling in buffered solution. Utilizing the H-bonding nature of these multilayers, we were able to micropattern the films to create more complex cell-resistant/-adhesive surfaces. The long-term stability of the cell-resistant multilayers was found to be exceptionally good even under conditions (pH 7.4, buffered solution) where a high degree of swelling takes place. No degradation of the micropatterned films was observed over a period of a month, during which time the multilayer coatings remained highly resistant to cell-adhesion.
Error resilient pyramid vector quantization for image compression (2002)

The robustness of image and video compression in the presence of time-varying channel error has received increased interest with the emergence of portable digital receivers and computers. To achieve robust compression, pyramid vector quantization (PVQ) can be used. It is a fixed-rate quantization scheme suited to Laplacian-like sources, such as those arising from transform and subband image coding. The authors propose a new method of PVQ which not only improves upon the image compression performance of typical JPEG implementations, but also demonstrates excellent resilience to channel error.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Regenerative capacity of intravenous autologous, allogeneic and human mesenchymal stem cells in the infarcted pig myocardium – complicated by myocardial tumor formation (2008)

Intravenously administered MSCs prevent pathologic remodeling and scar formation but bare potential risks from inflammatory-related products.
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling (2002)

The ubiquitination of the hypoxia-inducible factor (HIF) by the von Hippel-Lindau tumor suppressor (pVHL) plays a central role in the cellular response to changes in oxygen availability. pVHL binds to HIF only when a conserved proline in HIF is hydroxylated, a modification that is oxygen-dependent. The 1.85 angstrom structure of a 20-residue HIF-1alpha peptide-pVHL-ElonginB-ElonginC complex shows that HIF-1alpha binds to pVHL in an extended beta strand-like conformation. The hydroxyproline inserts into a gap in the pVHL hydrophobic core, at a site that is a hotspot for tumorigenic mutations, with its 4-hydroxyl group recognized by buried serine and histidine residues. Although the beta sheet-like interactions contribute to the stability of the complex, the hydroxyproline contacts are central to the strict specificity characteristic of signaling.
Beyond Nature's Chiral Pool: Enantioselective Catalysis in Industry (1993)

Enantioselective catalysts produce organic compounds in enantiomerically enriched form. They are highly efficient tools for the synthesis of biologically active materials, such as pharmaceuticals and crop-protection chemicals, in which enantiomeric purity can be critical. The design of chiral ligands is the key to developing new enantioselective catalysts. Three unusual families of ligands have been used to develop practical technology for enantioselective hydrocyanation of olefins, ring-opening of epoxides, and hydrogenation of various compounds.
Ratio cut partitioning for hierarchical designs (1991)

Circuit partitioning for hierarchical VLSI design is addressed. A partitioning approach called ratio cut is proposed. It is demonstrated that the ratio cut algorithm can locate the clustering structures in the circuit. Finding the optimal ratio cut is NP-complete. However, in certain cases the ratio cut can be solved by linear programming techniques via the multicommodity flow formulation. Also proposed is a fast heuristic algorithm running in linear time with respect to the number of pins in the circuit. Experiments show good results in all tested cases.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Treatment of Impaired Cerebral Function in Psychogeriatric Patients with Memantine - Results of a Phase II Double-Blind Study (1988)

Memantine was investigated in a phase II double-blind trial on 30 elderly patients by comparison with a placebo with the aid of several psychometric tests. It was found that vigilance, short-term memory, and concentration improve significantly under Memantine. It was also found that Memantine exerted a beneficial effect on psychiatric and neurological symptoms despite the presence of an organic psychosyndrome of many years' duration and multiple morbidity. The tolerance of the preparation was good in virtually all cases and a gradually increasing dosage is recommended. On the basis of these findings the authors assume that the therapeutic efficiency can be confirmed in a phase III trial.
TPX2 Is a Prognostic Marker and Contributes to Growth and Metastasis of Human Hepatocellular Carcinoma (2014)

Targeting protein for Xenopus kinesin-like protein 2 (TPX2), a microtubule-associated protein, impacts spindle assembly in human cells. Several studies have demonstrated that TPX2 is overexpressed in different types of human cancers and promotes tumor growth and metastasis. In this study, we found that the expression level of TPX2 was obviously higher in hepatocellular carcinoma (HCC) tissues than in matched nontumor tissues. Elevated expressions of TPX2 mRNA were observed in all HCC cell lines (HepG2, Hep3B, SMMC-7721, Bel-7402 and Huh7) as compared with that in a non-transformed hepatic cell line (LO2). Clinical analysis indicated that the positive expression of TPX2 was significantly correlated with venous infiltration, high Edmondson-Steiner grading and advanced TNM tumor stage in HCC. Furthermore, TPX2 was a novel prognostic marker for predicting 5-year overall survival (OS) and disease-free survival (DFS) of HCC patients. In vitro studies found that TPX2 knockdown significantly inhibited cell proliferation and viability in both Hep3B and HepG2 cells. Moreover, TPX2 knockdown obviously slowed down tumor growth in a nude mouse xenograft model. Otherwise, TPX2 knockdown prominently suppressed HCC cell invasion and migration. In conclusion, these results indicate that TPX2 may serve as a prognostic marker and promotes tumorigenesis and metastasis of HCC.
High rates of Ac/Ds germinal transposition in Arabidopsis suitable for gene isolation by insertional mutagenesis. (1992)

Overexpression of the Activator (Ac) transposase gene in Arabidopsis thaliana resulted in a minimal germinal transposition frequency of 27% in which independent Dissociation (Ds) transposition events were observed. Molecular analysis of 45 F1 generation Ac/Ds plants indicated that high rates of somatic excision had occurred, and independent germinal insertions were identified in F2 generation progeny plants. A tandem cauliflower mosaic virus (CaMV) promoter fused to two different Ac coding sequences significantly increased the rate of Ds transposition. The CaMV-Ac fusions activated single and multiple copies of two different Ds elements, DsDHFR and Ds35S-1, and reciprocal crosses resulted in similar transposition frequencies. The improved rate of independent germinal transposition observed makes Arabidopsis an ideal system for insertional mutagenesis.
Placenta growth factor expression is correlated with survival of patients with colorectal cancer (2005)

Our results suggest that PlGF expression correlates with disease progression and patient survival and may be used as a prognostic indicator for colorectal cancer.
Structural organization of the rat luteinizing hormone (LH) receptor gene (1991)

The luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptor gene was isolated from rat liver genomic libraries and spanned at least 75 kilobase pairs from nucleotide -2057 of the 5'-flanking region to the 3'-noncoding end. The structural configuration of the coding region of the LH receptor gene consists of 11 exons separated by 10 introns that are all located within the putative extracellular domain prior to the first transmembrane region. The 5'-noncoding region contains several potential TATA boxes and SP1 promoter binding sites, as well as six palindromic elements, potential intron/exon splice junctions, and two extended open reading frames in frame with the initiation codon. Primer extension studies indicate the presence of multiple transcriptional initiation sites. Truncated forms of the LH/hCG receptor conform to alternative splicing patterns that are consistent either with the deletion of complete exons or alternate acceptor sites within exons. All splice site junctions correspond to known donor and acceptor consensus sequences. Exons 2-8 approximate the regions of the 14 consecutive 20 amino acid repeated motifs present in the LH, thyrotropin-stimulating hormone, and follicle-stimulating hormone receptor cDNAs, with the exception of a six to eight amino acid shift in each motif. Exons 1, 9, 10, and 11, do not conform to this repetitive intronic motif. These exons, however, contain important structural elements including the conserved cysteines (exons 1, 9, 11), the soybean lectin motif (exon 9), the seven-transmembrane domain with cytoplasmic G protein coupling elements (exon 11), and three putative N-linked glycosylation sites (exon 10), consistent with preservation of significant functional domains within single exons. Exon 10 and the beginning of exon 11 along with the lectin motif are unique to the LH receptor and may be involved in specific association with the hormonal ligand. The homologous regions with other members of the glycoprotein receptor family encoded by exons 2-8, and the common amino acid motif that contains 3 conserved cysteines immediately prior to the first transmembrane region, may be involved in common hormonal interactions and in coupling functions, respectively.
High Expression of the Gluti Glucose Transporter in Human Brain Hemangioblastoma Endothelium (1995)

The principal glucose transporter at the blood-brain barrier is Glut1, and GLUT1 expression is downregulated in high grade gliomas. In the present study, glucose transporter expression was studied in surgically resected hemangioblastoma tissue. Light microscopic immunochemistry indicated the high expression of the Glut1 glucose transporter isoform throughout the central vascular endothelium of this tissue. Glial fibrillary acidic protein (GFAP) was observed only at the tumor border, with no GFAP immunoreactivity in stromal cells, pericytes or endothelia in the central tumor regions. It is generally believed that more Glut1 is found in erythrocytes than any other cell, but quantitative electron microscopic immunogold analyses of Glut1-immunoreactive sites per micron of capillary membrane showed the Glut1 density in tumor endothelial membranes glucose transporter was 2-3-fold higher than in human red cells. In the same tissue samples, qualitative immunogold electron microscopy of human serum albumin indicated that this protein (MW 65,000) moved freely from the vascular space into pericapillary regions, confirming the leaky barrier characteristics of the hemangioblastoma. These studies show that Glut1 expression may be high in endothelia that are highly permeable and devoid of astroglial contacts. Thus, human cerebral hemangioblastomas may provide a novel system for studying the induction of Glut1 in the blood-brain barrier.
Stool-based DNA testing, a new noninvasive method for colorectal cancer screening, the first report from Iran (2007)

We could detect colorectal cancer related genetic alterations by analyzing stool DNA with a sensitivity of 64% and 20% and a specificity of 95% and 100% for Long DNA and p16 respectively. A non-invasive molecular stool-based DNA testing can provide a screening strategy in high-risk individuals. However, additional testing on more samples is necessary from Iranian subjects to determine the exact specificity and sensitivity of these markers.
On-board four-dimensional digital tomosynthesis: First experimental results (2008)

The purpose of this study is to propose four-dimensional digital tomosynthesis (4D-DTS) for on-board analysis of motion information in three dimensions. Images of a dynamic motion phantom were reconstructed using acquisition scan angles ranging from 20 degrees (DTS) to full 360 degrees cone-beam computed tomography (CBCT). Projection images were acquired using an on-board imager mounted on a clinical linear accelerator. Three-dimensional (3D) images of the moving target were reconstructed for various scan angles. 3D respiratory correlated phase images were also reconstructed. For phase-based image reconstructions, the trajectory of a radiopaque marker was tracked in projection space and used to retrospectively assign respiratory phases to projections. The projections were then sorted according phase and used to reconstruct motion correlated images. By using two sets of projections centered about anterior-posterior and lateral axes, this study demonstrates how phase resolved coronal and sagittal DTS images can be used to obtain 3D motion information. Motion artifacts in 4D-DTS phase images are compared with those present in four-dimensional CT (4DCT) images. Due to the nature of data acquisition for the two modalities, superior-inferior motion artifacts are suppressed to a greater extent in 4D-DTS images compared with 4DCT. Theoretical derivations and experimental results are presented to demonstrate how optimal selection of image acquisition parameters including the frequency of projection acquisition and the phase window depend on the respiratory period. Two methods for acquiring projections are discussed. Preliminary results indicate that 4D-DTS can be used to acquire valuable kinetic information of internal anatomy just prior to radiation treatment.
Nonconcatenative finite-state morphology (1987)

Article Free Access Share on Nonconcatenative finite-state morphology Author: Martin Kay Xerox Palo Alto Research Center, Palo Alto, CA Xerox Palo Alto Research Center, Palo Alto, CAView Profile Authors Info & Claims EACL '87: Proceedings of the third conference on European chapter of the Association for Computational LinguisticsApril 1987 Pages 2–10https://doi.org/10.3115/976858.976860Online:01 April 1987Publication History 34citation420DownloadsMetricsTotal Citations34Total Downloads420Last 12 Months51Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Solution‐Processable Carbon Nanotubes for Semiconducting Thin‐Film Transistor Devices (2010)

CoMoCat single-walled carbon nanotubes (SWNTs) treated with diazonium salts can be used to fabricate solution-processable field-effect transistors (FETs) with a full semiconductor device yield. By increasing the network thickness, the effective mobility of the devices can be raised to ∼10 cm2 V−1 s−1 while keeping the on–off ratio higher than 5000. The removal of impurities is essential to achieve high-on–off-ratio devices. This approach is promising for preparation of SWNT inks for printing high-performance devices in flexible electronics.
Long-circulating bacteriophage as antibacterial agents. (1996)

The increased prevalence of multidrug-resistant bacterial pathogens motivated us to attempt to enhance the therapeutic efficacy of bacteriophages. The therapeutic application of phages as antibacterial agents was impeded by several factors: (i) the failure to recognize the relatively narrow host range of phages; (ii) the presence of toxins in crude phage lysates; and (iii) a lack of appreciation for the capacity of mammalian host defense systems, particularly the organs of the reticuloendothelial system, to remove phage particles from the circulatory system. In our studies involving bacteremic mice, the problem of the narrow host range of phage was dealt with by using selected bacterial strains and virulent phage specific for them. Toxin levels were diminished by purifying phage preparations. To reduce phage elimination by the host defense system, we developed a serial-passage technique in mice to select for phage mutants able to remain in the circulatory system for longer periods of time. By this approach we isolated long-circulating mutants of Escherichia coli phage lambda and of Salmonella typhimurium phage P22. We demonstrated that the long-circulating lambda mutants also have greater capability as antibacterial agents than the corresponding parental strain in animals infected with lethal doses of bacteria. Comparison of the parental and mutant lambda capsid proteins revealed that the relevant mutation altered the major phage head protein E. The use of toxin-free, bacteria-specific phage strains, combined with the serial-passage technique, may provide insights for developing phage into therapeutically effective antibacterial agents.
[Rheumatoid arthritis: psychosomatic aspects]. (2012)

The review considers the results of studies of the psychosomatic aspects of rheumatoid arthritis (RA), which have been published in the past 5 years. In particular, there is evidence for the impact of chronic pain on the psychological status of patients with RA, for that of the disease on quality of life in the patients, their sociopsychological and interpersonal relationships; trials of the efficiency of additional treatment options for RA are given.
Lipid Metabolism (1965)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Polyol Synthesis of Platinum Nanostructures: Control of Morphology through the Manipulation of Reduction Kinetics (2005)

Getting into shape: The shape of Pt0 nanostructures obtained by polyol synthesis can be altered by controlling the rate of reduction of the PtII precursor. Kinetic control is achieved by coupling the reduction with an FeII/FeIII redox reaction and/or by blocking the self-catalytic sites of the Pt particles with oxygen. The shapes of the nanoparticles (see picture for an example) are different from that of the thermodynamic product. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z462668_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Identification and Characterization of Major Lipid Particle Proteins of the Yeast Saccharomyces cerevisiae (1999)

Lipid particles of the yeast Saccharomyces cerevisiae were isolated at high purity, and their proteins were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Major lipid particle proteins were identified by mass spectrometric analysis, and the corresponding open reading frames (ORFs) were deduced. In silicio analysis revealed that all lipid particle proteins contain several hydrophobic domains but none or only few (hypothetical) transmembrane spanning regions. All lipid particle proteins identified by function so far, such as Erg1p, Erg6p, and Erg7p (ergosterol biosynthesis) and Faa1p, Faa4p, and Fat1p (fatty acid metabolism), are involved in lipid metabolism. Based on sequence homology, another group of three lipid particle proteins may be involved in lipid degradation. To examine whether lipid particle proteins of unknown function are also involved in lipid synthesis, mutants with deletions of the respective ORFs were constructed and subjected to systematic lipid analysis. Deletion of YDL193w resulted in a lethal phenotype which could not be suppressed by supplementation with ergosterol or fatty acids. Other deletion mutants were viable under standard conditions. Strains with YBR177c, YMR313c, and YKL140w deleted exhibited phospholipid and/or neutral lipid patterns that were different from the wild-type strain and thus may be further candidate ORFs involved in yeast lipid metabolism.