gebhart/patrepeval huggingface dataset:
Inflammation in Depression and the Potential for Anti-Inflammatory Treatment (2016)

Accumulating evidence supports an association between depression and inflammatory processes, a connection that seems to be bidirectional. Clinical trials have indicated antidepressant treatment effects for anti-inflammatory agents, both as add-on treatment and as monotherapy. In particular, nonsteroidal anti-inflammatory drugs (NSAIDs) and cytokine-inhibitors have shown antidepressant treatment effects compared to placebo, but also statins, poly-unsaturated fatty acids, pioglitazone, minocycline, modafinil, and corticosteroids may yield antidepressant treatment effects. However, the complexity of the inflammatory cascade, limited clinical evidence, and the risk for side effects stress cautiousness before clinical application. Thus, despite proof-of-concept studies of anti-inflammatory treatment effects in depression, important challenges remain to be investigated. Within this paper, we review the association between inflammation and depression together with the current evidence on use of anti-inflammatory treatment in depression. Based on this, we address the questions and challenges that seem most important and relevant to future studies, such as timing, most effective treatment lengths and identification of subgroups of patients potentially responding better to different anti-inflammatory treatment regimens. Keywords: Antidepressants, anti-inflammatory treatment, celecoxib, cytokine-inhibitors, depression, inflammation, statins.
Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression. (1991)

Murine Hox genes are organized into four clusters that share many features with the homeotic clusters of Drosophila. This evolutionary conservation and the clear relationships between the position of a gene within a cluster and its expression pattern have led to the suggestion that the structure of the cluster is essential for proper regulation. Using a Hox-2.6-lacZ reporter gene in transgenic mice we have shown that the overall expression pattern of the endogenous Hox-2.6 gene can be reconstructed when it is isolated from the complex. The transgene was expressed in the proper tissues, with the correct spatial distribution and temporal pattern. Furthermore, direct comparison by in situ hybridization revealed that the levels of transgene expression are similar to those of the endogenous gene. This has allowed us to define three elements that regulate particular aspects of the Hox-2.6 pattern, two of which act as spatially specific enhancers. One enhancer, region A, directed expression only in the neural tube, whereas the other, region C, specified the majority of the Hox-2.6 pattern. Both were also capable of imposing the correct boundaries of expression on heterologous promoters. The definition of such elements will allow the characterization of the trans-acting factors that mediate spatial regulation in the mammalian embryo.
A survey of more than 90 commercially available luminometers and imaging devices for low‐light measurements of chemiluminescence and bioluminescence, including instruments for manual, automatic and specialized operation, for HPLC, LC, GLC and microtitre plates. Part 2: Photographs (1992)

Part 1 of this survey comprised a description of the luminometers (J. Biolumin. Chemilumin. 7, 77-108 (1992)) and was compiled in January and February 1992 from information available in public domain literature requested by and supplied to the author by numerous companies in the previous two months. This part includes photographs of around 40 of these instruments. It is intended that updates to this review will be published at least annually in this journal and suppliers are invited to provide full technical details of new luminometric equipment to the author.
Poststimulation inhibition of the micturition reflex induced by tibial nerve stimulation in rats (2014)

The purpose of this study was to determine the effect of tibial nerve stimulation (TNS) on the micturition reflex. Experiments were conducted in 24 rats under urethane anesthesia. A catheter was inserted into the bladder via the bladder dome for saline infusion. A cuff electrode was placed around right tibial nerve for stimulation. TNS (5 Hz, 0.2 msec pulse width) at 2-4 times the threshold (T) intensity for inducing a toe movement was applied either during slow (0.08 mL/min) infusion of the bladder or for 30 min with an empty bladder. TNS had no effect on the micturition reflex when it was applied during slow bladder infusion. However, the 30-min TNS applied with an empty bladder induced poststimulation inhibition and significantly (P < 0.05) increased the bladder capacity to about 140% of prestimulation level in a 50-min period following the termination of stimulation. The bladder compliance was also significantly (P < 0.05) increased after the 30-min TNS. These results suggest that different mechanisms might exist in acute- and post-TNS inhibition of micturition reflex. The animal model developed in this study will be very useful for further investigations of the neurotransmitter mechanisms underlying tibial neuromodulation of bladder function.
Effect of Skin Model on In Vitro Performance of an Adhesive Dermally Applied Microarray Coated with Zolmitriptan (2018)

Franz cell studies, utilizing different human skin and an artificial membrane, evaluating the influence of skin model on permeation of zolmitriptan coated on an array of titanium microprojections, were evaluated. Full thickness and dermatomed <i>ex vivo</i> human skin, as well as a synthetic hydrophobic membrane (Strat-M®), were assessed. It was found that the choice of model demonstrated different absorption kinetics for the permeation of zolmitriptan. For the synthetic membrane only 11% of the zolmitriptan coated dose permeated into the receptor media, whilst for the dermatomed skin 85% permeated into the receptor. The permeation of zolmitriptan through full thickness skin had a significantly different absorption profile and time to maximum flux in comparison to the dermatomed skin and synthetic model. On the basis of these results dermatomed skin may be a better estimate of <i>in vivo</i> performance of drug-coated metallic microprojections.
Amino Acid Acylation: A Mechanism of Nitrogen Excretion in Inborn Errors of Urea Synthesis (1980)

Treatment of a patient deficient in carbamyl phosphate synthetase with benzoate or phenylacetic acid resulted in an increase in urinary nitrogen, which could be accounted for by the respective amino acid acylation product, hippurate or phenylacetylgultamine. Benzoate treatment of four hyperammonemic comatose patients led to clinical improvement and a return of plasma ammonium levels toward normal.
CD19 Selection Improves the Sensitivity of B Cell Lymphoma Detection (1998)

Reinfusion of residual tumor cells into B cell non-Hodgkin's lymphoma (B-NHL) patients during autologous transplantation may be an important cause of disease relapse. Determining the extent to which B-NHL cells are present in autologous progenitor cell products and if the presence of residual B-NHL cells is predictive of relapse will require extremely sensitive methods of detecting rare B-NHL cells. We attempted to improve the sensitivity of polymerase chain reaction (PCR)-based detection of rare B-NHL cells by preselecting CD19+ cells using an immunomagnetic column. To measure detection sensitivity, we prepared samples containing different levels of B-NHL cell contamination by mixing B-NHL cell lines containing the chromosomal translocation t(14;18) bcl-2/JH) with control leukapheresis samples. DNA extracted from each CD19-selected sample and from each matched nonselected sample was added to a PCR to amplify the bcl-2/JH breakdown junction. CD19 preselection improved the sensitivity of detection of t(14;18)-positive B-NHL cells 115-fold, so that B-NHL cells at a concentration of 1 tumor cell per 1 x 10(6) hematopoietic cells were detected in every specimen evaluated. t(14;18)-positive cells were not detected in any of 13 control leukapheresis specimens. We conclude that a combination of CD19 preselection and PCR amplification may improve the sensitivity of detection of rare lymphoma cells by two orders of magnitude without a significant decrease in specificity.
Control of pain initiation by endogenous cannabinoids (1999)

The potent analgesic effects of cannabis-like drugs and the presence of CB1-type cannabinoid receptors in pain-processing areas of the brain and spinal cord indicate that endogenous cannabinoids such as anandamide may contribute to the control of pain transmission within the central nervous system (CNS). Here we show that anandamide attenuates the pain behaviour produced by chemical damage to cutaneous tissue by interacting with CB1-like cannabinoid receptors located outside the CNS. Palmitylethanolamide (PEA), which is released together with anandamide from a common phospholipid precursor, exerts a similar effect by activating peripheral CB2-like receptors. When administered together, the two compounds act synergistically, reducing pain responses 100-fold more potently than does each compound alone. Gas-chromatography/mass-spectrometry measurements indicate that the levels of anandamide and PEA in the skin are enough to cause a tonic activation of local cannabinoid receptors. In agreement with this possibility, the CB1 antagonist SR141716A and the CB2 antagonist SR144528 prolong and enhance the pain behaviour produced by tissue damage. These results indicate that peripheral CB1-like and CB2-like receptors participate in the intrinsic control of pain initiation and that locally generated anandamide and PEA may mediate this effect.
A New Method to Produce MonoPEGylated Dimeric Cytokines Shown with Human Interferon-α2b (2009)

We have adapted the dock-and-lock (DNL) method into a novel PEGylation technology using human interferon-α2b (IFN-α2b) as an example. Central to DNL is a pair of distinct protein domains involved in the natural association between cAMP-dependent protein kinase (PKA) and A-kinase anchoring proteins (AKAPs). These domains serve as linkers for site-specific conjugation of poly(ethylene glycol) (PEG) to a dimeric form of IFN-α2b. The combination of a fusion protein comprising IFN-α2b and the dimerization-and-docking domain (DDD) of PKA with a PEG-derivatized anchoring domain (AD) of an interactive AKAP results in facile formation of a trimeric complex containing two copies of IFN-α2b and a single site-specifically linked PEG chain. Three such monoPEGylated dimers of IFN-α2b have been generated, the first with a 20 kDa linear PEG, referred to as α2b-362, the second with a 30 kDa linear PEG (α2b-413), and the third with a 40 kDa branched PEG (α2b-457). All three retained antiviral and antitumor activity in vitro and showed improved pharmacokinetic properties in mice, which translated into potent and prolonged therapeutic efficacy in the Daudi human lymphoma xenograft model. We anticipate wide applicability of the DNL method for developing long-acting therapeutics that are dimeric and monoPEGylated with the increased bioavailability allowing for less frequent dosing.
Recent advances in renal regeneration (2019)

Regeneration of a functional kidney from pluripotent stem cells (PSCs) is challenging because of its complex structure. Kidneys are derived from embryonic metanephros, which are composed of three progenitor cells: nephron progenitors, ureteric bud, and stromal progenitors. Nephron progenitors and ureteric bud have been induced successfully from PSCs as a result of the understanding of their detailed developmental process through cell-lineage tracing analysis. Moreover, these induced progenitors can be used to reconstruct the three-dimensional (3D) structure of kidneys <i>in vitro</i>, including glomeruli with podocytes, renal tubules, and the branching ureters. Induction of the remaining renal progenitors (that is, stromal progenitors from PSCs and the further maturation of reconstructed kidneys) needs to be studied extensively to regenerate functional and sophisticated kidneys from PSCs. In addition to the proper induction of renal progenitors, new bioengineering methods such as decellularization and 3D bioprinting and the recent advancements in the regeneration of kidneys in other species are promising leads for regenerating the complex spatial arrangement of kidneys, including the vascular network and urinary excretion pathway in humans.
Speech Denoising and Dereverberation Using Probabilistic Models (2000)

This paper presents a unified probabilistic framework for denoising and dereverberation of speech signals. The framework transforms the denoising and dereverberation problems into Bayes-optimal signal estimation. The key idea is to use a strong speech model that is pre-trained on a large data set of clean speech. Computational efficiency is achieved by using variational EM, working in the frequency domain, and employing conjugate priors. The framework covers both single and multiple microphones. We apply this approach to noisy reverberant speech signals and get results substantially better than standard methods. 1 Introduction This paper presents a statistical-model-based algorithm for reconstructing a speech source from microphone signals recorded in a stationary noisy reverberant environment. Speech enhancement in a realistic environment is a challenging problem, which remains largely unsolved in spite of more than three decades of research. Speech enhancement has many appl...
España y Marruecos: ¿hacia una agenda de reformas? (2005)

Este trabajo presenta la evolucion reciente de la politica espanola hacia Marruecos, senalando la cautela de Madrid en su apoyo a la reforma democratica del reino. Durante la ultima parte del gobierno del Partido Popular y bajo el presente gobierno del PSOE, se ha dado prioridad a la reconstruccion de las relaciones diplomaticas con Rabat. El apoyo a las reformas llevadas a cabo en Marruecos ha sido relativamente limitado y ha seguido una politica reactiva; la presion ejercida ha sido limitada, en respuesta a la creciente renuencia por parte de Mohamed VI de contemplar una democratizacion de mayor alcance. Esta cautela en temas de democracia y de derechos humanos se ha visto exacerbada por el aparente cambio en la politica del PSOE hacia la disputa sobre el Sahara Occidental, aunque, desde un punto de vista mas optimista, el trabajo sugiere que este cambio podria tambien abrir el camino para que Espana apoye la reforma a traves de un enfasis en la descentralizacion en Marruecos.
SUPRAMOLECULAR POLYMERS (1997)

RETURN TO ISSUEPREVNewsNEXTSUPRAMOLECULAR POLYMERSStructures held together by quadruple hydrogen bonding come apart reversiblyRON DAGANICite this: Chem. Eng. News 1997, 75, 48, 4Publication Date (Print):December 1, 1997Publication History Published online12 November 2010Published inissue 1 December 1997https://pubs.acs.org/doi/10.1021/cen-v075n048.p004https://doi.org/10.1021/cen-v075n048.p004newsACS PublicationsCopyright © 1997 AMERICAN CHEMICAL SOCIETYArticle Views9Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Noncovalent interactions,Polymers Get e-Alerts
Synthesis And Antimicrobial Activity Of Some New 1,2,4-Triazoles (2004)

A variety of 1,2,4-triazole derivatives were synthesized by esterifying substituted aryl carboxylic acid separately. It was then treated with hydrazine hydrate to yield corresponding aromatic acid hydrazides. When these hydrazides were treated with KOH and CS2, oxadiazoles were obtained. Thus obtained oxadiazoles on further treatment with different acid hydrazides afforded three different series of 1,2,4-triazole derivatives. All the newly synthesized compounds were screened for their antimicrobial activities and 1,2,4-triazoles of anthranilic acid series were found to be very active than the other two series of compounds.
Pathogen-Derived Resistance to a Potyvirus: Immune and Resistant Phenotypes in Transgenic Tobacco Expressing Altered Forms of a Potyvirus Coat Protein Nucleotide Sequence (1992)

Transgenic Nicotiana tabacum 'Burley 49' plants containing one of six different forms of the tobacco etch virus (TEV) coat protein (CP) nucleotide sequence have been generated. In whole plant studies, R1 and R2 progeny were inoculated mechanically with TEV, and the appearance and severity of symptoms were recorded. Symptom phenotype was altered, ranging from near wild type susceptibility to apparent immunity. Protoplasts derived from wild type and transgenic Burley 49 plant lines were transfected with TEV RNA. Protoplasts from transgenic plants expressing full-length or truncated forms of TEV CP supported virus replication. Protoplasts from certain transgenic plants, producing plus- or minus-sense CP transcripts but no CP, did not support virus replication at wild type levels. A model is proposed to account for these observations.
Diminution of the gut resistome after a gut microbiota-targeted dietary intervention in obese children (2016)

The gut microbiome represents an important reservoir of antibiotic resistance genes (ARGs). Effective methods are urgently needed for managing the gut resistome to fight against the antibiotic resistance threat. In this study, we show that a gut microbiota-targeted dietary intervention, which shifts the dominant fermentation of gut bacteria from protein to carbohydrate, significantly diminished the gut resistome and alleviated metabolic syndrome in obese children. Of the non-redundant metagenomic gene catalog of ~2 × 10(6) microbial genes, 399 ARGs were identified in 131 gene types and conferred resistance to 47 antibiotics. Both the richness and diversity of the gut resistome were significantly reduced after the intervention. A total of 201 of the 399 ARGs were carried in 120 co-abundance gene groups (CAGs) directly binned from the gene catalog across both pre-and post-intervention samples. The intervention significantly reduced several CAGs in Klebsiella, Enterobacter and Escherichia, which were the major hubs for multiple resistance gene types. Thus, dietary intervention may become a potentially effective method for diminishing the gut resistome.
A Synthesis of (+)-Herboxidiene A (1996)

Key steps in a stereoselective synthesis of Herboxidiene A, a diastereoisomer of the natural herbicide Herboxidiene, include a Hoppe homoaldol reaction, a copper(I)-mediated 1,2-metallate rearrangement, and a one-pot synthesis of a diene fragment from condensation of a lithiated benzothiazolyl sulfone and an aldehyde.
Incoherent Method of Optical Interference Cancellation for Radio-Frequency Communications (2009)

In this paper, we describe a system for cancelling radio-frequency (RF) interference using optical techniques. Specifically, we attempt to receive a weak RF signal-which we assume to be of the order of microwatts-in the presence of high-power local RF interference. This local interference is a signal whose power is of the order of 100 W and is generated in close proximity to the receiver. We wish to emphasize that the nature of the interfering signal is completely known to us in practice, since we are generating it for communications purposes. This knowledge of the interfering signal will prove to be useful in our attempts to cancel it, as will be shown. We refer to this technique as optical interference cancellation, or opto-cancellation. We have demonstrated that this opto-cancellation system can cancel a simple sinusoid at 3 GHz, as well as broadband interference of approximately 100-MHz bandwidth centered at 3 GHz. We have also demonstrated cancellation of sinusoids and broadband signals at other center frequencies as well. In the case of sinusoidal signals, we have demonstrated optical cancellation over 70 dB; and in the case of the ~ 100-MHz signal, we have demonstrated optical cancellation over 30 dB.
1$\,\times\,$4 Ge-on-SOI PIN Photodetector Array for Parallel Optical Interconnects (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> High-quality Ge film was epitaxially grown on silicon on insulator using the ultrahigh vacuum chemical vapor deposition. In this paper, we demonstrated that the efficient 1<formula formulatype="inline"><tex Notation="TeX">$\,\times\,$</tex> </formula>4 germanium-on-silicon p-i-n photodetector arrays with 1.0 <formula formulatype="inline"><tex Notation="TeX">$\mu$</tex></formula>m Ge film had a responsivity as high as 0.65 A/W at 1.31 <formula formulatype="inline"> <tex Notation="TeX">$\mu$</tex></formula>m and 0.32 A/W at 1.55 <formula formulatype="inline"><tex Notation="TeX">$\mu$</tex></formula>m, respectively. The dark current density was about 0.75 mA/cm<formula formulatype="inline"><tex Notation="TeX">$^{2}$</tex></formula> at 0 V and 13.9 mA/cm<formula formulatype="inline"><tex Notation="TeX">$^{2}$</tex></formula> at 1.0 V reverse bias. The detectors with a diameter of 25 <formula formulatype="inline"> <tex Notation="TeX">$\mu$</tex></formula>m were measured at 1550 nm incident light under 0 V bias, and the result showed that the 3-dB bandwidth is 2.48 GHz. At a reverse bias of 3 V, the bandwidth is about 13.3 GHz. The four devices showed a good consistency. </para>
Differential Induction of Antimicrobial REGIII by the Intestinal Microbiota and Bifidobacterium breve NCC2950 (2013)

The intestinal microbiota is a key determinant of gut homeostasis, which is achieved, in part, through regulation of antimicrobial peptide secretion. The aim of this study was to determine the efficiency by which members of the intestinal microbiota induce the antimicrobial peptide REGIII and to elucidate the underlying pathways. We showed that germfree mice have low levels of REGIII-γ in their ileum and colon compared to mice with different intestinal microbiota backgrounds. Colonization with a microbiota of low diversity (altered Schaedler flora) did not induce the expression of REGIII-γ as effectively as a complex community (specific pathogen free). Monocolonization with the probiotic Bifidobacterium breve, but not with the nonprobiotic commensal Escherichia coli JM83, upregulated REGIII-γ expression. Induction of REGIII-γ by B. breve was abrogated in mice lacking MyD88 and Ticam1 signaling. Both live and heat-inactivated B. breve but not spent culture medium from B. breve induced the expression of REGIII-α, the human ortholog and homolog of REGIII-γ, in human colonic epithelial cells (Caco-2). Taken together, the results suggest that REGIII-γ expression in the intestine correlates with the richness of microbiota composition. Also, specific bacteria such as Bifidobacterium breve NCC2950 effectively induce REGIII production in the intestine via the MyD88-Ticam1 pathway. Treatment with this probiotic may enhance the mucosal barrier and protect the host from infection and inflammation.