gebhart/patrepeval huggingface dataset:
Abstract 2753: The Relationship Between Pulmonary Vein Antrum Scarring Following Atrial Fibrillation Ablation and Procedural Success: Does Pulmonary Vein Isolation Matter? (2008)

Background. A mechanism of atrial fibrillation (AF) recurrence following ablation may be incomplete pulmonary vein antrum (PVA) scarring that allows for conduction between the pulmonary veins (PV) and the left atrium (LA). We report the relationship between circumferential PV scarring detected by delayed enhancement MRI (DE-MRI) and AF recurrence following PVAI. Methods. Eighty-six patients presenting for PVAI underwent DE-MRI 3 months post ablation. Circumferential ablation with posterior wall debulking was performed in all patients. PV ostia were marked on 3D images generated from the MRI data and assessed by consensus of two independent reviewers for the extent of scarring. Complete PVA scarring was defined as a continuous ring of enhancement surrounding the PVA. For patients with incomplete scarring, the degree of scarring was estimated. Results. The figure shows two patients from the cohort, Patient 1 exhibits successful scarring of all PVA. Patient 2 shows scarring of 1 PVA. At three months post ablation, complete circumferential lesion was seen on 131/335 PVA (39.1%). Complete scarring of 4 PVA was seen in 9 patients (10.5%), scarring of 3 PVA in 11 patients (12.8%) and scarring of 2 PVA was seen in 17 patients (19.8). Twenty-nine patients (33.7%) exhibited complete scarring in 1 PVA while 20 patients (23.3%) exhibited scarring in 0 PVA. Kaplan Meier analysis (Figure [E] ), suggests that PVA isolation may be important for long-term procedural success. Conclusion: Complete pulmonary vein antrum scarring exists in a very limited number of patients, despite its apparent importance for long-term procedural success.
RNA Synthesis by in Vitro Selected Ribozymes for Recreating an RNA World (2015)

The RNA world hypothesis states that during an early stage of life, RNA molecules functioned as genome and as the only genome-encoded catalyst. This hypothesis is supported by several lines of evidence, one of which is the in vitro selection of catalytic RNAs (ribozymes) in the laboratory for a wide range of reactions that might have been used by RNA world organisms. This review focuses on three types of ribozymes that could have been involved in the synthesis of RNA, the core activity in the self-replication of RNA world organisms. These ribozyme classes catalyze nucleoside synthesis, triphosphorylation, and the polymerization of nucleoside triphosphates. The strengths and weaknesses regarding each ribozyme's possible function in a self-replicating RNA network are described, together with the obstacles that need to be overcome before an RNA world organism can be generated in the laboratory.
Natural Gas Fired Combined Cycles With Low CO2 Emissions (2000)

This paper assesses performances and economic viability of CO2 removal by chemical absorption from the flue gases of natural gas-fired Combined Cycles, more specifically for two configurations: one where CO2 is removed ahead of the stack without modifying the power cycle; the other where part of the flue gases is recirculated to the gas turbine, thereby reducing the flow to be treated by chemical absorption. In both cases sequestered CO2 is made available at conditions suitable to storage into deep oceanic waters. Performances and cost of electricity are evaluated for systems based on large, heavy-duty turbines representative of state-of-the-art “FA” technology. Carbon sequestration reduces net plant efficiency and power output by about 10 percent and increases the cost of electricity from 36 to about 50 mills/kWh. Flue gas recirculation warrants slightly higher efficiencies and lower costs. CO2 removal is eventually compared with other strategies for the reduction of CO2 emissions, like switching existing coal-fired steam plants to natural gas or replacing existing steam plants with conventional CCs. At current fuel prices the latter appears the option of choice, with a cost of about $25 per tonn of avoided CO2 emission. [S0742-4795(00)02803-9]
Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl‐l‐histidyl‐l‐lysine copper (1994)

A multicenter, randomized, evaluator-blinded, placebo-controlled clinical study was conducted to evaluate the safety and effectiveness of glycyl-l-histidyl-l-lysine: copper complex (lamin Gel) in the treatment of diabetic neuropathic ulcers. All patients were enrolled in an aggressive standardized wound care protocol consisting of sharp debridement at study entry, daily application of a metered dose of drug, standardized pressure-relieving footwear, and patient education relating to diabetes control and activity modifications. Treatment with lamin Gel significantly increased the percentage of closure of plantar ulcers (98.5% median area percentage closure compared with 60.8% for vehicle; p < 0.05) and the proportion of patients healing 98% or better. The rate of closure was three times faster with lamin Gel treatment compared with standard care and vehicle. The enhancement of wound closure was more pronounced (median of 89.2% compared with -10.3% for vehicle; p < 0.01) in larger (greater than 100 mm(2) initial area at study entry) plantar ulcers caused by the failure of this size of ulcer to respond adequately to standardized wound care treatments in the absence of lamin Gel. Treatment must commence immediately after the initial wound debridement to obtain optimal enhancement of the ulcer closure. The incidence of ulcer infections was significantly lower (7% incidence compared with 34% for vehicle, p < 0.05) in the plantar ulcers treated immediately after debridement with the lamin Gel.
The BER performance of OFDM systems using non-synchronized sampling (2002)

In fully digital receivers, carrier and timing information is derived from samples of the (anti-aliasing-filtered) received continuous-time signal. In case of synchronized sampling, this information is used to align the sampling clock of the receiver with the remote transmit clock. In nonsynchronized sampling systems, the sampling at the receiver is performed by means of a fixed free-running clock, and additional post-processing is necessary to perform timing correction in the digital domain. We investigate the effect of non-synchronized sampling on the BER performance of OFDM systems. We calculate the BER degradation caused by a given frequency offset between receiver and transmitter clock, as compared with the case of ideal sampling. The obtained results are compared with the performance of synchronized sampling systems.
Characterization of the Core Rumen Microbiome in Cattle during Transition from Forage to Concentrate as Well as during and after an Acidotic Challenge (2013)

This study investigated the effect of diet and host on the rumen bacterial microbiome and the impact of an acidotic challenge on its composition. Using parallel pyrosequencing of the V3 hypervariable region of 16S rRNA gene, solid and liquid associated bacterial communities of 8 heifers were profiled. Heifers were exclusively fed forage, before being transitioned to a concentrate diet, subjected to an acidotic challenge and allowed to recover. Samples of rumen digesta were collected when heifers were fed forage, mixed forage, high grain, during challenge (4 h and 12 h) and recovery. A total of 560,994 high-quality bacterial sequences were obtained from the solid and liquid digesta. Using cluster analysis, prominent bacterial populations differed (P≤0.10) in solid and liquid fractions between forage and grain diets. Differences among hosts and diets were not revealed by DGGE, but real time qPCR showed that several bacteria taxon were impacted by changes in diet, with the exception of Streptococcus bovis. Analysis of the core rumen microbiome identified 32 OTU's representing 10 distinct bacterial taxa including Bacteroidetes (32.8%), Firmicutes (43.2%) and Proteobacteria (14.3%). Diversity of OTUs was highest with forage with 38 unique OTUs identified as compared to only 11 with the high grain diet. Comparison of the microbial profiles of clincial vs. subclinical acidotic heifers found a increases in the relative abundances of Acetitomaculum, Lactobacillus, Prevotella, and Streptococcus. Increases in Streptococcus and Lactobacillus likely reflect the tolerance of these species to low pH and their ability to proliferate on surplus fermentable carbohydrate. The acetogen, Acetitomaculum may thereforeplay a role in the conversion of lactate to acetate in acidotic animals. Further profiling of the bacterial populations associated with subclinical and clinical acidosis could establish a microbial fingerprint for these disorders and provide insight into whether there are causative microbial populations that could potentially be therapeutically manipulated.
A Well-Behaved Revolute Flexure Joint for Compliant Mechanism Design (1999)

This paper describes the design of a unique revolute flexure joint, called a split-tube flexure, that enables (lumped compliance) compliant mechanism design with a considerably larger range-of-motion than a conventional thin beam flexure, and additionally provides significantly better multi-axis revolute joint characteristics. Conventional flexure joints utilize bending as the primary mechanism of deformation. In contrast, the split-tube flexure joint incorporates torsion as the primary mode of deformation, and contrasts the torsional properties of a thin-walled open-section member with the bending properties of that member to obtain desirable joint behavior. The development of this joint enables the development of compliant mechanisms that are quite compliant along kinematic axes, extremely stiff along structural axes, and are capable of kinematically well-behaved large motions.
Challenges and opportunities in estimating viral genetic diversity from next-generation sequencing data (2012)

Many viruses, including the clinically relevant RNA viruses HIV (human immunodeficiency virus) and HCV (hepatitis C virus), exist in large populations and display high genetic heterogeneity within and between infected hosts. Assessing intra-patient viral genetic diversity is essential for understanding the evolutionary dynamics of viruses, for designing effective vaccines, and for the success of antiviral therapy. Next-generation sequencing (NGS) technologies allow the rapid and cost-effective acquisition of thousands to millions of short DNA sequences from a single sample. However, this approach entails several challenges in experimental design and computational data analysis. Here, we review the entire process of inferring viral diversity from sample collection to computing measures of genetic diversity. We discuss sample preparation, including reverse transcription and amplification, and the effect of experimental conditions on diversity estimates due to in vitro base substitutions, insertions, deletions, and recombination. The use of different NGS platforms and their sequencing error profiles are compared in the context of various applications of diversity estimation, ranging from the detection of single nucleotide variants (SNVs) to the reconstruction of whole-genome haplotypes. We describe the statistical and computational challenges arising from these technical artifacts, and we review existing approaches, including available software, for their solution. Finally, we discuss open problems, and highlight successful biomedical applications and potential future clinical use of NGS to estimate viral diversity.
Barbarin as a New Tyrosinase Inhibitor from Barbarea orthocerus (1999)

A tyrosinase inhibitor was isolated from the whole plant of Barbarea orthocerus Led. (Brassicaceae) by activity-guided fractionation, and identified as (R)-5-phenyl-2-oxazolidinethione (barbarin) by structural analysis followed by comparison with reported spectral data. The compound exhibited significant inhibitory effects on mushroom and murine tyrosinases at more than 1.6 x 10(-5) M. Barbarin exhibited IC50 values of 4.2 x 10(-5) M on mushroom tyrosinase and of 4.8 x 10(-5) M on murine tyrosinase. Kojic acid as a positive control exhibited IC50 values of 3.4 x 10(-5) M and 6.0 x 10(-5) M on mushroom and murine tyrosinases, respectively. Therefore, barbarin exhibited a similar level of inhibitory potency with kojic acid used as a positive control. In a kinetic study with various concentrations of L-dopa as the substrate, barbarin was identified as an uncompetitive inhibitor and kojic acid as a mixed inhibitor of both mushroom and murine tyrosinases. Barbarin exhibited KEIS values of 3.3 x 10(-5) M and 3.6 x 10(-5) M on mushroom and murine tyrosinases, respectively. Kojic acid exhibited KEIS and KEI values of 2.4 x 10(-5) M and 2.2 x 10(-5) M on mushroom tyrosinase and those of 8.9 x 10(-5) M and 7.2 x 10(-5) M on murine tyrosinase, respectively.
An Image-Space Refinement Criterion for Linear Hierarchical Radiosity (1997)

A Linear Hierarchical Radiosity method using point collocation and triangle meshes is proposed that allows C0 continuity and performs energy exchange at any level both in the shooter and the receiver; this method leads to an exact representation of the Gouraud shading interpolation that will be used for rendering. A new refinement criterion is presented which tries to improve image quality taking into account: the smoothness of the solution based on pixel intensity values instead of energy ones, and visibility changes along the surfaces for high gradient detection (sharp shadows). In order to perform a efficient refinement a data structure is proposed which isolates every shooter contribution over each receiver and allows to only refine high error interactions.
Genetically Engineered and Synthetic Allergen Derivatives: Candidates for Vaccination against Type I Allergy (1999)

Type I allergy, a hypersensitivity disease affecting almost 20% of the population worldwide, is based on the IgE recognition of otherwise harmless antigens (i.e., allergens). Allergen-induced crosslink of effector cell-bound IgE antibodies leads to the release of biological mediators and thus to immediate disease symptoms (allergic rhinitis, conjunctivitis and asthma). Specific immunotherapy, the only causative treatment of Type I allergy, is based on the administration of increasing doses of allergens to allergic patients in order to yield allergen-specific non-responsiveness. Major disadvantages are 1. that current forms of allergen immunotherapy are performed with allergens difficult to standardize which cannot be matched to the patients reactivity profile and 2. that the administration of active allergen preparations can cause anaphylactic side effects. Through the application of molecular biological techniques many relevant environmental allergens have been produced as active recombinant proteins which allow component-resolved allergy diagnosis and thus represent the basis for patient-tailored forms of immunotherapy. Here we review molecular strategies which have been recently applied to generate genetically engineered and synthetic hypoallergenic allergen derivatives for patient-tailored and safe vaccination against Type I allergy.
Histology Image Classification Using Supervised Classification and Multimodal Fusion (2010)

The fast development of microscopy imaging techniques nowadays promotes the generation of a large amount of data. These data are very crucial not only for theoretical biomedical research but also for clinical usage. In order to decrease the inter-intra observer variability and save the human effort on labeling and classifying these images, a lot of research efforts have been devoted to the development of algorithms for biomedical images. Among such efforts, histology image classification is one of the most important areas due to its broad applications in pathological diagnosis such as cancer diagnosis. To improve classification accuracy, most of the previous work focuses on extracting more features and building algorithms for a specific task. This paper proposes a framework based on the novel and robust Collateral Representative Subspace Projection Modeling (C-RSPM) supervised classification model for general histology image classification. In the proposed framework, a cell image is first divided into 25 blocks to reduce the spatial complexity of computation, and one C-RSPM model is built on each block set which contains blocks in the same location from different images. For each testing image, our proposed framework first classifies each of its blocks using the C-RSPM classification model built for that block set, and then applies a multimodal late fusion algorithm with a weighted majority voting strategy to decide the final class label of the whole image. Experimenting using three-fold cross validation with three benchmark histology data sets shows that the proposed framework outperforms other well-known classifiers in the comparison and gives better results than the highest accuracy reported previously.
Tyrosine Kinase Inhibitors. 19. 6-Alkynamides of 4-Anilinoquinazolines and 4-Anilinopyrido[3,4-d]pyrimidines as Irreversible Inhibitors of the erbB Family of Tyrosine Kinase Receptors (2006)

Structure-activity relationships for inhibition of erbB1, erbB2, and erbB4 were determined for a series of alkynamide analogues of quinazoline- and pyrido[3,4-d]pyrimidine-based compounds. The compounds were prepared by coupling the appropriate 6-aminoquinazolines or 6-aminopyrido[3,4-d]pyrimidines with alkynoic acids, using EDCI.HCl in pyridine. The compounds showed pan-erbB enzyme inhibition but were on average about 10-fold more potent against erbB1 than against erbB2 and erbB4. For cellular inhibition, the nature of the alkylating side chains was an important determinant, with 5-dialkylamino-2-pentynamide type Michael acceptors providing the highest potency. This is suggested to be due to an improved ability of the amine to participate in an autocatalysis of the Michael reaction with enzyme cysteine residues. Pyrido[3,4-d]pyrimidine analogue 39 was selected for in vivo evaluation and achieved tumor regressions at 10 mg/kg in the A431 human epidermoid carcinoma and at 40 mg/kg for the SF767 human glioblastoma and the SKOV3 human ovarian carcinoma. Complete stasis was observed at 40 mg/kg in the BXPC3 human pancreatic carcinoma as well as in the H125 human non-small-cell lung carcinoma.
A biped robot that keeps steps in time with musical beats while listening to music with its own ears (2007)

We aim at enabling a biped robot to interact with humans through real-world music in daily-life environments, e.g., to autonomously keep its steps (stamps) in time with musical beats. To achieve this, the robot should be able to robustly predict the beat times in real time while listening to musical performance with its own ears (head-embedded microphones). However, this has not previously been addressed in most studies on music-synchronized robots due to the difficulty in predicting the beat times in real-world music. To solve this problem, we implemented a beat-tracking method developed in the field of music information processing. The predicted beat times are then used by a feedback-control method that adjusts the robot's step intervals to synchronize its steps in time with the beats. The experimental results show that the robot can adjust its steps in time with the beat times as the tempo changes. The resulting robot needed about 25 [s] to recognize the tempo change after it and then synchronize its steps.
Causal Interactions in Attention Networks Predict Behavioral Performance (2012)

Lesion and functional brain imaging studies have suggested that there are two anatomically nonoverlapping attention networks. The dorsal frontoparietal network controls goal-oriented top-down deployment of attention; the ventral frontoparietal network mediates stimulus-driven bottom-up attentional reorienting. The interaction between the two networks and its functional significance has been considered in the past but no direct test has been carried out. We addressed this problem by recording fMRI data from human subjects performing a trial-by-trial cued visual spatial attention task in which the subject had to respond to target stimuli in the attended hemifield and ignore all stimuli in the unattended hemifield. Correlating Granger causal influences between regions of interest with behavioral performance, we report two main results. First, stronger Granger causal influences from the dorsal attention network (DAN) to the ventral attention network (VAN), i.e., DAN→VAN, are generally associated with enhanced performance, with right intraparietal sulcus (IPS), left IPS, and right frontal eye field being the main sources of behavior-enhancing influences. Second, stronger Granger causal influences from VAN to DAN, i.e., VAN→DAN, are generally associated with degraded performance, with right temporal-parietal junction being the main sources of behavior-degrading influences. These results support the hypothesis that signals from DAN to VAN suppress and filter out unimportant distracter information, whereas signals from VAN to DAN break the attentional set maintained by the dorsal attention network to enable attentional reorienting.
xin qi dian xin lan tu xin lu jing (2006)

今年两会与往年略有不同,它将为我国今年和未来五年的经济社会发展作出重大战略部署,推动我国在新的历史起点上朝着全面建设小康社会的目标迈进。因此,格外引起各方关注。温总理在政府工作报告中说,2005年中国取得的成绩喜人,经济呈现增长较快、效益较好、价格较稳的良好局面。全年国内生产总值达到18.23万亿元,比上年增长9.9%;财政收入突破3万亿元,增加5232亿元;居民消费价格总水平上涨1.8%。但是,一些长期积累的和深层次的矛盾尚未根本解决,又出现了一些不容忽视的新问题。主要是:经济结构不合理,自主创新能力不强,能源资源消耗过大,环
Public Participation in International Processes: Environmental Case Studies at the National and International Levels (1996)

The environment is now a highly productive area of concerted international activity.In recent years many environmental issues, such as stratospheric ozone depletion and exports of hazardous wastes, have become "internationalized" through shifts from domestic to international fora.Other environmental problems, such as the greenhouse effect, have been taken up in multilateral settings in the first instance, before any obvious prior domestic analogue was in place.Certainly this trend toward multilateral treatment of international environmental problems has much to recommend it.
Gain-of-function Na v 1.8 mutations in painful neuropathy (2012)

Painful peripheral neuropathy often occurs without apparent underlying cause. Gain-of-function variants of sodium channel Na(v)1.7 have recently been found in ∼30% of cases of idiopathic painful small-fiber neuropathy. Here, we describe mutations in Na(v)1.8, another sodium channel that is specifically expressed in dorsal root ganglion (DRG) neurons and peripheral nerve axons, in patients with painful neuropathy. Seven Na(v)1.8 mutations were identified in 9 subjects within a series of 104 patients with painful predominantly small-fiber neuropathy. Three mutations met criteria for potential pathogenicity based on predictive algorithms and were assessed by voltage and current clamp. Functional profiling showed that two of these three Na(v)1.8 mutations enhance the channel's response to depolarization and produce hyperexcitability in DRG neurons. These observations suggest that mutations of Na(v)1.8 contribute to painful peripheral neuropathy.
A robust layered control system for a mobile robot (1986)

A new architecture for controlling mobile robots is described. Layers of control system are built to let the robot operate at increasing levels of competence. Layers are made up of asynchronous modules that communicate over low-bandwidth channels. Each module is an instance of a fairly simple computational machine. Higher-level layers can subsume the roles of lower levels by suppressing their outputs. However, lower levels continue to function as higher levels are added. The result is a robust and flexible robot control system. The system has been used to control a mobile robot wandering around unconstrained laboratory areas and computer machine rooms. Eventually it is intended to control a robot that wanders the office areas of our laboratory, building maps of its surroundings using an onboard arm to perform simple tasks.