Surfactant Systems: Their chemistry, pharmacy and biology (1983)

1. Surface activity.- 1.1 Amphipathic molecules.- 1.2 Surface activity in aqueous solution.- 1.3 Adsorption at liquid surfaces.- 1.4 Adsorption at solid surfaces.- 1.5 The wettability of solid surfaces.- 1.6 Modification of the surface properties of solids by adsorbed surfactants.- References.- 2. Phase behaviour of surfactants.- 2.1 Introduction.- 2.2 Liquid crystalline phases in binary surfactant systems.- 2.3 Liquid crystalline phases in ternary surfactant systems.- 2.4 Factors affecting phase behaviour.- 2.5 Quaternary phase systems.- References.- 3. Micellization.- 3.1 Introduction.- 3.2 Micellar structure.- 3.3 Micellar shape.- 3.4 Polydispersity of micellar size.- 3.5 Factors affecting the CMC and micellar size.- 3.6 Thermodynamics of micelle formation.- 3.7 Kinetics of micelle formation.- 3.8 Non-micellar association.- 3.9 Micelle formation in non-aqueous solvents.- References.- 4. Surface activity and colloidal properties of drugs and naturally occurring substances.- 4.1 Colloidal properties of drugs.- 4.2 Some biological consequences of drug surface activity.- 4.3 Biological relevance of micelle formation by drug molecules.- 4.4 Naturally occurring micelle formers: the bile salts, phospholipids and related systems.- References.- 5. Solubilization.- 5.1 Introduction.- 5.2 Experimental methods of studying solubilization.- 5.3 Mobility of solubilizate molecules.- 5.4 Factors influencing solubilization.- 5.5 Effect of solubilizate on micellar properties.- 5.6 Solubilization in non-aqueous solvents.- References.- 6. Pharmaceutical aspects of solubilization.- 6.1 Introduction.- 6.2 Solubilization of drugs.- 6.3 Pharmaceutical aspects of solubilization in non-aqueous systems.- 6.4 Solubilization with block co-polymeric surfactants.- 6.5 Polymer-surfactant interactions.- 6.6 Surfactant interactions with oppositely charged species.- 6.7 Hydrotropy in pharmaceutical systems.- References.- 7. Biological implications of surfactant presence in formulation.- 7.1 Introduction.- 7.2 Effect of surfactants on dissolution of drugs.- 7.3 Effect of surfactants on membrane permeability.- 7.4 Effect of surfactants on drug absorption.- 7.5 Miscellaneous formulations and the influence of surfactants.- 7.6 Surfactants and antibacterial activity.- 7.7 Utilization of solubilization in drug delivery systems.- References.- 8. Emulsions.- 8.1 Introduction.- 8.2 Aspects of emulsion stability.- 8.3 Multiple emulsions.- 8.4 Microemulsions.- 8.5 Viscosity and rheological characteristics of emulsions.- 8.6 Solute disposition in emulsion systems.- 8.7 Biopharmaceutical aspects of emulsions.- References.- 9. Surfactants in suspension systems.- 9.1 Introduction.- 9.2 Settling of suspended particles.- 9.3 Suspension stability.- 9.4 Effect of surfactants on the adsorptive capacity of suspensions.- 9.5 Rheological characteristics of suspensions.- 9.6 Crystal changes in suspensions.- 9.7 Bacterial and other cell suspensions.- References.- 10. Aspects of surfactant toxicity.- 10.1 Introduction.- 10.2 Metabolism of surfactants.- 10.3 Interactions of surfactants with membranes and membrane components.- 10.4 Toxicology of surfactants.- 10.5 Surfactants and plant systems.- References.- 11. Reactivity in surfactant systems.- 11.1 Introduction.- 11.2 Chemistry at interfaces.- 11.3 Micellar reactions.- 11.4 Stability of drugs in surfactant systems.- 11.5 Stability of surfactant systems.- 11.6 Polymerization of surface-active molecules.- 11.7 Some analytical consequences of surfactant presence.- References.