gebhart/patrepeval huggingface dataset:
High-dynamic-range fiber gyro with all-digital signal processing (1991)

The paper describes a compact (50-cu cm) fiber-optic gyro (FOG) prototype with a dynamic range of +/- 1500 deg per sec and a bias stability of 1 deg per hour. The FOG uses an all-digital signal processing scheme which is intrinsically free of electronic bias drift, making it possible to work over the whole potential dynamic range of the FOG without degrading the bias performances. With a stability and a linearity of 10 ppm, this FOG is a good candidate for high-performance tactical-grade applications. A configuration scheme of the FOG prototype is presented.
Prognostic factors in resected pancreatic adenocarcinoma: Analysis of actual 5-year survivors1 (2004)

We conclude that longterm survival from pancreatic adenocarcinoma is possible if the disease is identified in its early stages. These and other similar data should provide further stimulus for the development and evaluation of novel screening strategies to improve early detection of this disease.
Biochemical strategy of cancer cells and the design of chemotherapy: G. H. A. Clowes Memorial Lecture. (1983)

Une connaissance de la strategie biochimique des cellules cancereuses et de la «voie royale» pour la conception de la chimiotherapie anticancereuse dirigee par l'enzymogramme. Dans cet article on souligne l'essence et la substance des progres theoriques et experimentaux vers une connaissance de la strategie biochimique et de la logique de l'expression des genes dans les cellules cancereuses et on identifie un programme enzymatique et metabolique commun dans les diverses tumeurs animales et humaines
Fas, IL-7, and T cells: live and let die (2008)

In the context of HIV-driven, prolonged overactivation of the immune system, ultimately leading to AIDS, Rethi and colleagues have identified key components able to support both life and death of immune-competent T cells.
Hyperbranched polymers: advances from synthesis to applications (2015)

Hyperbranched polymers (HPs) are highly branched three-dimensional (3D) macromolecules. Their globular and dendritic architectures endow them with unique structures and properties such as abundant functional groups, intramolecular cavities, low viscosity, and high solubility. HPs can be facilely synthesized via a one-pot polymerization of traditional small molecular monomers or emerging macromonomers. The great development in synthetic strategies, from click polymerization (i.e., copper-catalyzed azide-alkyne cycloaddition, metal-free azide-alkyne cycloaddition, strain-promoted azide-alkyne cycloaddition, thiol-ene/yne addition, Diels-Alder cycloaddition, Menschutkin reaction, and aza-Michael addition) to recently reported multicomponent reactions, gives rise to diverse HPs with desirable functional/hetero-functional groups and topologies such as segmented or sequential ones. Benefiting from tailorable structures and correspondingly special properties, the achieved HPs have been widely applied in various fields such as light-emitting materials, nanoscience and technology, supramolecular chemistry, biomaterials, hybrid materials and composites, coatings, adhesives, and modifiers. In this review, we mainly focus on the progress in the structural control, synthesis, functionalization, and potential applications of both conventional and segmented HPs reported over the last decade.
Biomechanics of Pitching With Emphasis Upon Shoulder Kinematics (1993)

The American Sports Medicine Institute conducts research to increase understanding of mechanisms involved in upper extremity injuries to throwing athletes. This paper presents a qualitative overview of pitching and a detailed quantitative description of arm motion about the shoulder during this highly dynamic activity. Data on kinematics of arm motions about the shoulder are presented for 29 elite throwers. The major motion about the shoulder is external/internal rotation. Scapulothoracic and glenohumeral flexibility permit the arm to reach an externally rotated position of 175 degrees. Approximately 30 msec before release, the arm internally rotates 80 degrees, reaching peak angular velocities near 7,000 degrees/sec. In rehabilitation of injured throwers, there is a need to appreciate the highly dynamic nature of this skill and to attempt to simulate these dynamic motions and loads as part of the final phase of treatment before the athlete returns to competition.
A Point Mutation, E95D, in the Mumps Virus V Protein Disengages STAT3 Targeting from STAT1 Targeting (2009)

Mumps virus, like other paramyxoviruses in the Rubulavirus genus, encodes a V protein that can assemble a ubiquitin ligase complex from cellular components, leading to the destruction of cellular signal transducer and activator of transcription (STAT) proteins. While many V proteins target the interferon-activated STAT1 or STAT2 protein, mumps virus V protein is unique in its ability to also target STAT3 for ubiquitin modification and proteasome-mediated degradation. Here we report that a single amino acid substitution in the mumps virus V protein, E95D, results in defective STAT3 targeting while maintaining the ability to target STAT1. Results indicate that the E95D mutation disrupts the ability of the V protein to associate with STAT3. A recombinant mumps virus carrying the E95D mutation in its P and V proteins replicates normally in cultured cells but fails to induce targeting of STAT3. Infection with the recombinant virus results in the differential regulation of a number of cellular genes compared to wild-type mumps virus and increases cell death in infected cells, producing a large-plaque phenotype.
Microbiota dysbiosis is associated with HPV‑induced cervical carcinogenesis (2018)

Cervical microbial communities serve a crucial role in the persistence and development of oncogenic human papilloma virus (HPV) infections. In the present study, the authors hypothesised that disturbed heterogeneity of microbial flora was associated with HPV-induced carcinogenesis. Swabs of the cervical microbiota were collected from 250 women and the 16S ribosomal DNA was sequenced using a high throughput assay. The swabs of cervical microbiota were grouped according to the community state types (CSTs) as follows: Healthy cervical swabs; swabs taken from low-grade squamous intra-epithelial lesions (LSIL) and swabs taken from high-grade squamous intra-epithelial lesions (HSIL). Analysis of the bacterial classes revealed that the CST cervical swabs of the volunteers were characterised by <i>Lactobacillus crispatus, Lactobacillus iners</i> and <i>Lactobacillus taiwanensis</i>, however, <i>Gardnerella vaginalis</i> and <i>Lactobacillus acidophilus</i> were absent. In the CST of patients with LSIL the predominant type of bacteria was <i>Lactobacillus acidophilus</i> and <i>Lactobacillus iners</i>, however <i>Lactobacillus crispatus</i> was not detected. Swabs from CST women diagnosed with HSIL exhibited abundant <i>Gardnerella vaginalis</i> and <i>Lactobacillus acidophilus</i>, however, lacked <i>Lactobacillus taiwanensis, Lactobacillus iners</i> and <i>Lactobacillus crispatus</i>. The abundance of <i>Lactobacillus acidophilus</i> in swabs from the healthy women was compared with the swabs from the women with LSIL. The results of the present study indicated that the development of HPV-induced cancer is associated with a high diversity of vaginal microbiota, which is involved in the control of viral persistence, and is therefore indicative of disease prognosis.
Sutureless microvascular anastomosis using a neodymium‐yag laser (1980)

A technique is described in which a Neodymium-YAG laser is used to anastomose arteries 0.8 to 1.0 mm in diameter. Heat generated by the laser causes fusion of the collagen of the media, making direct handling of the vessel wall unnecessary. Four variations of the technique were performed in 120 rat carotid arteries. Angiographic and scanning electron microscopic studies were carried out immediately after surgery and at intervals of 1 day to 6 months after anastomosis. Patency rates as high as 92.5% were recorded. The technique that produced the most secure anastomosis was considered to be one in which a vascular strut was used as an aid in apposition, followed by the application of a piece of vein wall to the anastomosis with tissue adhesive. The main advantages of the laser technique are speed and consistency. Complications such as disruption and aneurysm formation are considered to be rare.
Is pericapsular nerve group (PENG) block a true pericapsular block? (2019)

To the editor, We would like to comment further on the brief technical report on the pericapsular nerve group block recently published in Regional Anesthesia & Pain Medicine .[1][1] Although the analgesic effect of this block was remarkable, the distribution of injectate spread relative to the
Cystic Fibrosis Pulmonary Guidelines: Treatment of Pulmonary Exacerbations (2009)

The natural history of cystic fibrosis lung disease is one of chronic progression with intermittent episodes of acute worsening of symptoms frequently called acute pulmonary exacerbations These exacerbations typically warrant medical intervention. It is important that appropriate therapies are recommended on the basis of available evidence of efficacy and safety. The Cystic Fibrosis Foundation therefore established a committee to define the key questions related to pulmonary exacerbations, review the clinical evidence using an evidence-based methodology, and provide recommendations to clinicians. It is hoped that these guidelines will be helpful to clinicians in the treatment of individuals with cystic fibrosis.
The double jeopardy of HDL (2005)

The ability of high-density lipoprotein (HDL) to promote cholesterol efflux is thought to be important in its protection against cardiovascular disease. Anti-inflammatory properties of HDL have emerged as additional properties that may also be important. HDL appears to have evolved as part of the innate immune system functioning to inhibit inflammation in the absence of an acute phase response (APR) but functioning to increase inflammation in the presence of an APR. Inbred strains of mice that are genetically susceptible to atherosclerosis have pro-inflammatory HDL, while inbred strains that are resistant to atherosclerosis have anti-inflammatory HDL. In one small study, humans with coronary heart disease (CHD) or CHD equivalents had pro-inflammatory HDL prior to statin therapy and about half continued to have pro-inflammatory HDL after statin therapy despite a profound decrease in plasma lipids. Pro-inflammatory HDL was relatively weak in its ability to promote cholesterol efflux while anti-inflammatory HDL was better in promoting cholesterol efflux. In other studies, oxidative alterations of the major protein of HDL, apolipoprotein A-I (apoA-I), impaired the ability of the apoA-I to promote cholesterol efflux. Thus, HDL structure and function may be more important than HDL-cholesterol levels in predicting risk for cardiovascular disease.
Leukocyte antimicrobial peptides: multifunctional effector molecules of innate immunity (2000)

Antimicrobial peptides are effector molecules of innate immunity that provide a first line of defense against pathogens. In mammals, they are stored in granules of leukocytes and are present in those sites that are exposed to microbial invasion, such as mucosal surfaces and skin. In the last decade, biochemical investigations and recombinant DNA technology have allowed the identification and characterization of several antimicrobial peptides from various animal and vegetal species. Most of the mammalian peptides have been grouped in two broad families: defensins and cathelicidin-derived peptides. Functional studies have shown that the toxicity mechanisms for many peptides consist of a rapid permeabilization of the target cell membrane. In addition to their microbicidal activity, some members of both families are multifunctional molecules, playing a modulating role in the inflammation and the antigen-driven immune response.
Control functions and grid qualities measurements in the elliptic grid generation around arbitrary surfaces (2000)

This paper describes the three-dimensional elliptic grid generation. The two-dimensional approach for the control functions obtained by modifying the Thomas–Middlecoff method is applied on the planes perpendicular to the main flow direction co-ordinate, which is assumed to be the function of only one corresponding co-ordinate in the computational domain. The grid orthogonality is improved by about 40 per cent compared with that of the algebraic initial grid. Copyright © 2000 John Wiley & Sons, Ltd.
Significance and Mediation of Neural and Other Biofeedback (1979)

Click to increase image sizeClick to decrease image size Additional informationNotes on contributorsBruce E. HetzlerJoyce Laing works in the Department of Child and Family Psychiatry, Playfield House, Cupar, Fife, and is a Consultant Art Therapist to Psychiatric Hospitals and Prisons and Chairwoman of the Scottish Society of Art and Psychology.
Expression of Sindbis virus structural proteins via recombinant vaccinia virus: synthesis, processing, and incorporation into mature Sindbis virions (1985)

We have obtained a vaccinia virus recombinant which contains a complete cDNA copy of the 26S RNA of Sindbis virus within the thymidine kinase gene of the vaccinia virus genome. This recombinant constitutively transcribed the Sindbis sequences throughout the infectious cycle, reflecting the dual early-late vaccinia promoter used in this construction. The Sindbis-derived transcripts were translationally active, giving rise to both precursor and mature structural proteins of Sindbis virus, including the capsid protein (C), the precursor of glycoprotein E2 (PE2), and the two mature envelope glycoproteins (E1 and E2). These are the same products translated from the 26S mRNA during Sindbis infection, and thus these proteins were apparently cleaved, glycosylated, and transported in a manner analogous to that seen during authentic Sindbis infections. By using epitope-specific antibodies, it was possible to demonstrate that recombinant-derived proteins were incorporated into Sindbis virions during coinfections with monoclonal antibody-resistant Sindbis variants. These results suggest that all the information necessary to specify the proper biogenesis of Sindbis virus structural proteins resides within the 26S sequences and that vaccinia may provide an appropriate system for using DNA molecular genetic manipulations to unravel a variety of questions pertinent to RNA virus replication.
Interactive control of pulsed field gel electrophoresis via real time monitoring (1992)

The migration of DNA fragment bands through a slab gel can be monitored by UV absorption at 254 nm and imaged by a charge-coupled device (CCD) camera. Background correction and immediate viewing of band positions to interactively change the field program in pulsed-field gel electrophoresis is possible throughout the run via this detection scheme. The use of absorption removes the need for staining or radioisotope labelling, thereby simplifying sample preparation and reducing hazardous waste generation. This leaves the DNA in its native state and further analysis can be performed without destaining. The optimization of buffer concentration, electric field strength, temperature, agarose concentration, as well as pulse duration can considerably reduce total run time. For example, DNA from 2 to 850 kb can be separated in 3 h on a 7-cm gel with interactive control of the pulse time, which is 10 times faster than using a constant field program.
Non-data-aided carrier offset estimators for OFDM with null subcarriers: identifiability, algorithms, and performance (2001)

The ability of orthogonal frequency-division multiplexing systems to mitigate frequency-selective channels is impaired by the presence of carrier frequency offsets (CFOs). In this paper, we investigate identifiability issues involving high-resolution techniques that have been proposed for blind CFO estimation based on null subcarriers. We propose new approaches that do not suffer from the lack of identifiability and adopt adaptive algorithms that are computationally feasible. The performance of these techniques in relation to the location of the null subcarriers is also investigated via computer simulations and compared with the modified Cramer-Rao bound.
The Sequence of the Human Epidermal 58-kD (#5) Type II Keratin Reveals an Absence of 5′ Upstream Sequence Conservation between Coexpressed Epidermal Keratins (1988)

We report the isolation and sequencing of cDNA and genomic clones encoding the complete sequence of the human 58-kD epidermal keratin (#5). The sequence specifies a protein of 62,471 daltons that contains a central alpha-helical segment capable of forming a coiled-coil structure flanked by regions that are not alpha-helical. A comparison of the primary sequence with the known sequences of other intermediate filament proteins reveals many common motifs. The 58-kD keratin is highly similar to other type II keratins and less similar to type I keratins and other intermediate filament proteins. The 58-kD keratin is regulated by retinoids in several tissues and is one of four keratins abundantly expressed in epidermal keratinocytes, where it may be important in maintaining structural integrity of the integument. A comparison of the keratin 5 sequence with coexpressed keratin 14 reveals an absence of sequence conservation in regulatory regions and suggests that common sequence elements may not be necessary for coordinate expression of type I and type II keratin partners. Interestingly, keratin 5 contains only one region weakly resembling the SV40 enhancer-like sequence found in some other keratins indicating that this sequence motif may not be necessary for regulation or abundant expression of all epidermal keratins.
Carbohydrate-deficient Transferrin as a Marker of Chronic Alcohol Abuse: A Critical Review of Preanalysis, Analysis, and Interpretation (2001)

Asialo- and disialo-Fe(2)-Tf, which lack one or two complete N-glycans, and monosialo-Fe(2)-Tf (structure remains unclear) are collectively referred to as CDT. Diminished mRNA concentration and glycoprotein glycosyltransferase activities involved in Tf N-glycan synthesis and increased sialidase activity most likely account for alcohol-induced increases in CDT. Knowledge about in vivo and in vitro effects on serum CDT is poor. Reliable CDT and non-CDT fractionation is needed for CDT measurement. Analysis methods with different analytical specificities and recoveries decreased the comparability of values and statistical parameters of the diagnostic efficiency of CDT. CDT is the most specific marker of chronic alcohol abuse to date. Efforts should concentrate on the pathomechanisms (in vivo), preanalysis, and standardization of CDT analysis.
Lethal photosensitization of oral pathogens via red‐filtered halogen lamp (2005)

Our in-vitro data indicate that we were able to achieve lethal photosensitization of two common oral pathogens with high intensity red filtered HL in the presence of diluted MB. In this era of increased incidence of antibiotic resistance, bacterial killing with laser or light energy in the presence of photosensitizing agent can prove to be a valuable treatment modality.
Discrimination of eating habits with a wearable bone conduction sound recorder system (2009)

Continuous monitoring of eating habits could be useful in preventing lifestyle diseases such as the metabolic syndrome. Conventional methods consist in self-reporting and mastication frequency calculation from myoelectric potential of the masseter muscle, both resulting in a significant burden for the user. We developed a non-invasive wearable sensing system that can record eating habits over a long period of time in daily life. Our original sensing system is composed by a bone conduction microphone placed in the ears, from which sound data are collected to a portable IC recorder. Applying frequency spectrum analysis on collected sound data, we could not only count the mastication number during eating, but also accurately differentiate eating, drinking, and speaking activities, which can be used to evaluate the regularity of meals. Moreover, using clustering of sound spectra, we found it is possible to classify types of foods eaten regarding their texture.
Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica (2013)

Neuromyelitis optica (NMO) is an autoimmune disease targeting aquaporin 4 (AQP4), localized mainly at the astrocytic foot processes. Loss of AQP4 and glial fibrillary acidic protein (GFAP) was reported, but the pathological significance of astrocytopathy is still controversial. Here we show that active lesions in NMO display a wide spectrum of pathology even within a single tissue block of an individual patient. We have distinguished six different lesion types. The first reflects complement deposition at the surface of astrocytes, associated with granulocyte infiltration and astrocyte necrosis and followed by demyelination, global tissue destruction and the formation of cystic, necrotic lesions (lesion type 2). Such destructive lesions lead to Wallerian degeneration in lesion-related tracts (lesion type 3). Around active NMO lesions AQP4 may selectively be lost in the absence of aquaporin 1 (AQP1) loss or other structural damage (lesion type 4). Another pattern is characterized by clasmatodendrosis of astrocytes, defined by cytoplasmic swelling and vacuolation, beading and dissolution of their processes and nuclear alterations resembling apoptosis, which was associated with internalization of AQP4 and AQP1 and astrocyte apoptosis in the absence of complement activation. Such lesions give rise to extensive astrocyte loss, which may occur in part in the absence of any other tissue injury, such as demyelination or axonal degeneration (lesion type 5). Finally, lesions with a variable degree of astrocyte clasmatodendrosis are found, which show plaque-like primary demyelination that is associated with oligodendrocyte apoptosis, but with preservation of axons (lesion type 6). In active multiple sclerosis (MS) lesions astrocytes reveal changes of reactive protoplasmatic or fibrillary gliosis. Only in a subset of lesions, in patients with aggressive disease, loss of AQP4 is observed in the initial stage of their formation, which is associated with retraction of astrocyte processes in the absence of complement deposition, granulocyte infiltration or loss of AQP1 or astrocytes. Our data underline the primary assault of astrocytes in NMO lesions, but also indicate that different mechanisms of tissue injury operate in parallel in the same patient and even within the same lesion.