gebhart/patrepeval huggingface dataset:
Head Pose Estimation System Based on Particle Filtering with Adaptive Diffusion Control (2005)

In this paper, we propose a new tracking system based on a stochastic filtering framework for reliably estimating the 3D pose of a user’s head in real-time. Our system estimates the pose of a user’s head in each image frame whose 3D model is automatically obtained at an initialization step. In particular, our estimation method is designed to control the diffusion factor of a motion model adaptively. This technique contributes significantly to improving the following performance simultaneously: the robust tracking against abrupt head motion and the accurate pose estimation when the user is staring at a point in a scene. The performance of our proposed method has been successfully demonstrated via experiments. 1
Oral Consumption of Green Tea Polyphenols Inhibits Insulin-Like Growth Factor-I–Induced Signaling in an Autochthonous Mouse Model of Prostate Cancer (2004)

We earlier demonstrated that oral infusion of green tea polyphenols inhibits development and progression of prostate cancer in transgenic adenocarcinoma of the mouse prostate (TRAMP) model. Evidence indicates that elevated levels of IGF-I with concomitant lowering of IGF binding protein (IGFBP)-3 are associated with increased risk for prostate cancer development and progression. In this study, we examined the role of IGF/IGFBP-3 signaling and its downstream and other associated events during chemoprevention of prostate cancer by green tea polyphenols in TRAMP mice. Our data demonstrated an increase in the levels of IGF-I, phosphatidylinositol 3'-kinase, phosphorylated Akt (Thr-308), and extracellular signal-regulated kinase 1/2 with concomitant decrease in IGFBP-3 in dorso-lateral prostate of TRAMP mice during the course of cancer progression, i.e., as a function of age. Continuous green tea polyphenol infusion for 24 weeks to these mice resulted in substantial reduction in the levels of IGF-I and significant increase in the levels of IGFBP-3 in the dorso-lateral prostate. This modulation of IGF/IGFBP-3 was found to be associated with an inhibition of protein expression of phosphatidylinositol 3'-kinase, phosphorylated forms of Akt (Thr-308) and extracellular signal-regulated kinase 1/2. Furthermore, green tea polyphenol infusion resulted in marked inhibition of markers of angiogenesis and metastasis most notably vascular endothelial growth factor, urokinase plasminogen activator, and matrix metalloproteinases 2 and 9. Based on our data, we suggest that IGF-I/IGFBP-3 signaling pathway is a prime pathway for green tea polyphenol-mediated inhibition of prostate cancer that limits the progression of cancer through inhibition of angiogenesis and metastasis.
Plasmon-Enhanced Colorimetric ELISA with Single Molecule Sensitivity (2011)

Robust but ultrasensitive biosensors with a capability of detecting low abundance biomarkers could revolutionize clinical diagnostics and enable early detection of cancer, neurological diseases, and infections. We utilized a combination of localized surface plasmon resonance (LSPR) refractive index sensing and the well-known enzyme-linked immunosorbent assay to develop a simple colorimetric biosensing methodology with single molecule sensitivity. The technique is based on spectral imaging of a large number of isolated gold nanoparticles. Each particle binds a variable number of horseradish peroxidase (HRP) enzyme molecules that catalyze a localized precipitation reaction at the particle surface. The enzymatic reaction dramatically amplifies the shift of the LSPR scattering maximum, λ(max), and makes it possible to detect the presence of only one or a few HRP molecules per particle.
Distributed data-parallel computing using a high-level programming language (2009)

The Dryad and DryadLINQ systems offer a new programming model for large scale data-parallel computing. They generalize previous execution environments such as SQL and MapReduce in three ways: by providing a general-purpose distributed execution engine for data-parallel applications; by adopting an expressive data model of strongly typed .NET objects; and by supporting general-purpose imperative and declarative operations on datasets within a traditional high-level programming language.
Preparation and Evaluation of Eudragit Gels. V. Rectal Gel Preparations for Sustained Release and Avoidance of First-Pass Metabolism of Lidocaine. (1992)

The release of lidocaine from hydrogel and xerogel preparations was remarkably suppressed compared with polyethylene glycol (PEG) 2000 suppository. The release rate of lidocaine from hydrogel and xerogel increased with the increase in the amount of sodium hydroxide incorporated within the range of 3 to 7 milliequivalent (meq). After an oral administration of lidocaine HCl solution, the plasma concentration of lidocaine was considerably lower than that after intravenous administration for all time periods. The absolute bioavailability (F(oral)) was 5.63%. For the Witepsol S-55 and PEG 2000 suppositories, the plasma levels of lidocaine were higher than those for the oral preparation, and Cmax and area under the concentration-time curve (AUC) values significantly improved (p < 0.01). The absolute bioavailabilities were 21.3 and 29.6%, respectively. On the other hand, Eudispert hv-hydrogel and xerogel preparations showed the characteristics of a sustained-release preparation, especially the xerogel preparation with 5 meq NaOH. Absolute bioavailability for hydrogel and xerogel preparations increased significantly (p < 0.05) by approximately 1.7-3.4 folds compared with those of Witepsol S-55 and PEG 2000 suppositories.
What Do Patients Consider to Be the Most Important Outcomes for Effectiveness Studies on Migraine Treatment? Results of a Delphi Study (2014)

The currently used outcome measures in migraine research do not sufficiently reflect the wishes of patients. Patients want the medication to work faster, to take away pain at an earlier stage, to make them able to function properly quickly, and to prevent recurrence. These aspects should be considered in future evaluation of new attack medication for migraine.
Ribozyme Structures and Mechanisms (2001)

The past few years have seen exciting advances in understanding the structure and function of catalytic RNA. Crystal structures of several ribozymes have provided detailed insight into the folds of RNA molecules. Models of other biologically important RNAs have been constructed based on structural, phylogenetic, and biochemical data. However, many questions regarding the catalytic mechanisms of ribozymes remain. This review compares the structures and possible catalytic mechanisms of four small self-cleaving RNAs: the hammerhead, hairpin, hepatitis delta virus, and in vitro-selected lead-dependent ribozymes. The organization of these small catalysts is contrasted to that of larger ribozymes, such as the group I intron.
Autologous bone marrow transplantation in acute leukemia: a phase I study of in vitro treatment of marrow with 4- hydroperoxycyclophosphamide to purge tumor cells (1985)

This phase I study was conducted to determine the maximal safe concentration of 4-hydroperoxycyclophosphamide (4HC) that could be used for in vitro treatment of bone marrow from patients with acute leukemia undergoing autologous bone marrow transplantation. Concentrations of 40 to 120 micrograms/mL of 4HC were used in 30 patients with relapsed or high-risk acute leukemia and in six patients with nonleukemic malignancies. All patients received marrow-lethal cytoreductive therapy followed by infusion of the 4HC-treated marrow. Complete inhibition of granulocyte and macrophage colony-forming cells was obtained at 80 micrograms/mL. Nevertheless, only one transplant-related death and otherwise full hematologic recovery was observed at concentrations of 4HC up to 100 micrograms/mL. At 120 micrograms/mL, there were three transplant-related deaths, including two of the three patients who required the infusion of reserve marrow. Among the acute leukemia patients, three remain in complete remission at 1,337, 1,017, and 967 days after transplant. Among the nonleukemic patients, two remain in complete remission at 1,081 and 1,017 days after transplant. At the maximum safe concentration of 4HC (100 micrograms/mL), satisfactory hematologic recovery can be obtained, despite elimination of detectable hematopoietic progenitors.
HPLC Analysis of Allicin and Other Thiosulfinates in Garlic Clove Homogenates (1991)

Reversed-phase high Performance liquid chromatography (C18-HPLC) was used to separate and quantitate all the detectable alkyl and alkenyl thiosulfinates, including configurational isomers, of garlic homogenates. Pure thiosulfinates were synthesized or isolated and identified by (1)H-NMR, and their extinction coefficients determined. Some configurational isomers required Separation by silica-HPLC. Five previously unreported thiosulfinates have been found, four of which contain the TRANS-1-propenyl group and increase several-fold to over half the content of allicin upon storage of garlic bulbs at 4 degrees C with a concomitant decrease in a gamma-glutamyl peptide. The variation in thiosulfinate yield between different countries, stores, bulbs, cloves, and storage times was investigated. A method for standardizing the quantitation of allicin yield from garlic is proposed and compared to other methods of allicin analysis.
Cloning, and expression in Escherichia coli K-12, of the chromosomal hemolysin (phospholipase C) determinant of Pseudomonas aeruginosa (1983)

A hemolysin determinant was cloned from Pseudomonas aeruginosa PA103 by inserting Sau3a-generated DNA fragments between the BamHI sites of the lambda replacement vector WL47.1. A 9.5-kilobase HindIII fragment encoding the hemolysin was subcloned from this phage and inserted into the plasmid vector pHC79 to generate the recombinant plasmid pKC95. Escherichia coli K-12 strains harboring pKC95 exhibited zones of hemolysis after several days of growth on blood agar plates. Hemolysis was shown to be due to phospholipase C activity by using the chromogenic substrate p-nitrophenylphosphorylcholine. Deletion mutants of pKC95 were isolated, and polypeptides expressed from these plasmids were examined by using the E. coli minicell system. A polypeptide of 78,000 daltons was associated with phospholipase C activity. The hemolytic activity was cell associated when expressed in E. coli.
Coanda Wall Jet Calculations Using One- and Two-Equation Turbulence Models (2006)

The wall jet over a convex surface, the Coanda wall jet, has many potential technical applications, such as circulation control of airfoils. Reynolds-averaged Navier-Stokes is a potentially very powerful tool for Coanda wall jet calculations. A number of common linear eddy-viscosity turbulence models were used for Reynolds-averaged Navier-Stokes calculations of a turbulent Coanda wall jet experiment. Calculations were also carried out with an explicit algebraic stress model. The differences in the computed results were shown to be large depending on what turbulence model was employed. The k-w model was then employed for three-dimensional Reynolds-averaged Navier-Stokes calculations where the downstream evolution of streamwise vortices in the turbulent wall jet was studied for various spanwise wavelengths and forcing amplitudes. It was found that a centrifugal instability of the turbulent mean flow may lead to the streamwise growth of longitudinal vortices. Beyond a certain disturbance amplitude threshold the relative phase of the vortices had a noticeable impact on the amplification rates and the mean flow characteristics were affected by the added wall normal momentum exchange.
Polymer-supported poly(amino acids) as new asymmetric epoxidation catalyst of .alpha.,.beta.-unsaturated ketones (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolymer-supported poly(amino acids) as new asymmetric epoxidation catalyst of .alpha.,.beta.-unsaturated ketonesShinichi Itsuno, Minako Sakakura, and Koichi ItoCite this: J. Org. Chem. 1990, 55, 24, 6047–6049Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/jo00311a024https://doi.org/10.1021/jo00311a024research-articleACS PublicationsRequest reuse permissionsArticle Views698Altmetric-Citations133LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Tumor-infiltrating macrophages (CD68(+) cells) and prognosis in malignant uveal melanoma. (2001)

The number of tumor-infiltrating CD68-positive macrophages contributes to prognosis and associates with cell type and microvascular density, which merits a further analysis of the biological role of these cells in uveal melanoma.
Agrin-induced Activation of Acetylcholine Receptor-bound Src Family Kinases Requires Rapsyn and Correlates with Acetylcholine Receptor Clustering (2001)

During neuromuscular synaptogenesis, neurally released agrin induces aggregation and tyrosine phosphorylation of acetylcholine receptors (AChRs) by acting through both the receptor tyrosine kinase MuSK (muscle-specific kinase) and the AChR-associated protein, rapsyn. To elucidate this signaling mechanism, we examined tyrosine phosphorylation of AChR-associated proteins, particularly addressing whether agrin activates Src family kinases bound to the AChR. In C2 myotubes, agrin induced tyrosine phosphorylation of these kinases, of AChR-bound MuSK, and of the AChR beta and delta subunits, as observed in phosphotyrosine immunoblotting experiments. Kinase assays revealed that the activity of AChR-associated Src kinases was increased by agrin, whereas phosphorylation of the total cellular kinase pool was unaffected. In both rapsyn-deficient myotubes and staurosporine-treated C2 myotubes, where AChRs are not clustered, agrin activated MuSK but did not cause either Src family or AChR phosphorylation. In S27 mutant myotubes, which fail to aggregate AChRs, no agrin-induced phosphorylation of AChR-bound Src kinases, MuSK, or AChRs was observed. These results demonstrate first that agrin leads to phosphorylation and activation of AChR-associated Src-related kinases, which requires rapsyn, occurs downstream of MuSK, and causes AChR phosphorylation. Second, this activation intimately correlates with AChR clustering, suggesting that these kinases may play a role in agrin-induced AChR aggregation by forming an AChR-bound signaling cascade.
Retrieval by shape similarity with perceptual distance and effective indexing (2000)

An important problem in accessing and retrieving visual information is to provide efficient similarity matching in large databases. Though much work is being done on the investigation of suitable perceptual models and the automatic extraction of features, little attention is given to the combination of useful representations and similarity models with efficient index structures. In this paper we propose retrieval by shape similarity using local descriptors and effective indexing. Shapes are partitioned into tokens in correspondence with their protrusions, and each token is modeled according to a set of perceptually salient attributes. Shape indexing is obtained by arranging shape tokens into a suitably modified M-tree index structure. Two distinct distance functions model respectively, token and shape perceptual similarity. Examples from a prototype system and computational experiences are reported for both retrieval accuracy and indexing efficiency. Shape retrieval has been tested under shape scaling, orientation changes, and partial shape occlusions. A comparative analysis of different indexing structures, for shape retrieval is presented.
A non-isotopic assay for histone deacetylase activity (1999)

Inhibitors of histone deacetylase (HD) bear great potential as new drugs due to their ability to modulate transcription and to induce apoptosis or differentiation in cancer cells. To study the activity of HD and the effect of potential inhibitors in vitro so far only radio-active assays have existed. For the search of new inhibitors and for the use in HD identification and purification we established a simple, non-radioactive assay that allows screening of large numbers of compounds. The assay is based on an aminocoumarin derivative of an Omega-acetylated lysine as enzyme substrate.
6D Relocalisation for RGBD Cameras Using Synthetic View Regression (2012)

With the advent of real-time dense scene reconstruction from handheld cameras, one key aspect to enable robust operation is the ability to relocalise in a previously mapped environment or after loss of measurement. Tasks such as operating on a workspace, where moving objects and occlusions are likely, require a recovery competence in order to be useful. For RGBD cameras, this must also include the ability to relocalise in areas with reduced visual texture. This paper describes a method for relocalisation of a freely moving RGBD camera in small workspaces. The approach combines both 2D image and 3D depth information to estimate the full 6D camera pose. The method uses a general regression over a set of synthetic views distributed throughout an informed estimate of possible camera viewpoints. The resulting relocalisation is accurate and works faster than framerate and the system’s performance is demonstrated through a comparison against visual and geometric feature matching relocalisation techniques on sequences with moving objects and minimal texture.
Review of Polyclonal Antibody Production Procedures in Mammals and Poultry (1995)

In recent years the production of antibodies (Abs) in laboratory animals has become an essential part of many research projects. Investigators preparing to produce antibodies are confronted with a number of complex choices, some of which may be critical for success. The goal is to obtain high-titer, high-affinity antisera in a manner consistent with the welfare of the animals being immunized. Investigators not familiar with antibody (Ab) production require some guidelines to carry out immunizations in an appropriate manner. Recent studies of components of the immune system, their functions, and the actions of adjuvants on the immune system have yielded valuable information for understanding immune responses. The following discussion is an attempt to provide the non-immunologist with a rational basis for making decisions about choices of animal, immunization procedures, and adjuvants. An overview of the humoral immune response is included to provide a basis for understanding the function of adjuvants and immunization strategies. Additional information may be obtained from any of several immunology textbooks (Janeway and Travers, 1994; Paul, 1993). Although optimization of procedures is still largely empirical, successful production of useful Abs can usually be accomplished by following currently available guidelines.
Studies on Cardiac Ingredients of Plants. VII. Chemical Transformation of Proscillaridin by Means of the Diels-Alder Reaction and Biological Activities of Its Derivatives. (1991)

The Diels-Alder reactions of a cardiac glycoside, proscillaridin (1), with some dienophiles were investigated. The reaction of 1 with alkenes such as methyl vinyl ketone and methyl acrylate afforded 3-oxo-2-oxabicyclo[2.2.2]oct-7-enes (2-5) and para-substituted benzene derivatives (6 and 7), while 1 reacted with alkynes (3-butyn-2-one, methyl propiolate) to yield para- or meta-substituted benzene derivatives (6-9). The biological activities of the resulting derivatives were evaluated by the use of isolated guinea-pig papillary muscle preparations and Na+,K(+)-adenosine triphosphatase (ATPase) preparation from dog kidney. Among the proscillaridin derivatives, compounds 4 and 7 moderately inhibited Na+,K(+)-ATPase activity. Furthermore, the concentration range of 7 over which its positive inotropic effect on guinea-pig papillary muscle preparations, increased from 5% to 95% of maximum was broader than that of 1, i.e., concentration dependency was maintained over a greater range of concentration.
Prognosis of chronic lymphocytic leukemia: a multivariate regression analysis of 325 untreated patients (1987)

Three hundred twenty-five previously untreated patients with chronic lymphocytic leukemia were analyzed to identify significant prognostic factors for survival. Univariate analysis identified the following characteristics associated with survival: (1) clinical characteristics: age, race, sex, performance status, lymphadenopathy, and hepatosplenomegaly; (2) hematologic parameters: WBC count, absolute lymphocyte and granulocyte counts, hemoglobin level, and platelet count; and (3) biochemical parameters: serum albumin, calcium, uric acid, lactate dehydrogenase, alkaline phosphatase, BUN, and creatinine. Multivariate regression analysis in a randomly selected training subset of 217 patients demonstrated that the combination of uric acid, alkaline phosphatase, lactate dehydrogenase, external lymphadenopathy, and age had the strongest predictive relation to survival time. The resulting model was validated in the remaining independent subset of 108 patients and led to classification of patients into low, intermediate, and high-risk groups with five-year survival rates of 75%, 59%, and 14%, respectively, and with distinctively different annual mortality rates (P less than .01). Both the regression model and Rai staging were highly effective in identifying risk groups among the entire patient population (P less than 0.001). Overall the regression model was superior to Rai staging in defining prognostic risk groups. In addition, it was able to separate patients into significantly different risk categories within each Rai stage, thus improving on the prognostic prediction of individual patients with chronic lymphocytic leukemia.
How Wages are Set: Uncertain Political Marginal Productivity: Price Theory, Wage Theory, Agency Theory, and the Theory of the Firm (2000)

In this paper, I will derive a new model of wage prices by starting with price theory and wage theory and then blending in the cost factors uncovered by agency theory and the theory of the firm, and Alchian's work on economic uncertainty. The final result is still theoretical and cannot be used to predict a specific workers wage, but is nevertheless more complete and realistic in detailing the process of wage determination.
PARTIAL DIFFERENTIAL EQUATIONS FOR PRODUCTS OF TWO CLASSICAL ORTHOGONAL POLYNOMIALS (2005)

We give a method to derive partial differential equations for the product of any two classical orthogonal polynomials in one variable and thus find several new differential equations. We also explain with an example that our method can be extended to a more general case such as product of two sets of orthogonal functions.