gebhart/patrepeval huggingface dataset:
A family of linear complexity likelihood ascent search detectors for CDMA multiuser detection (2002)

We propose a family of likelihood ascent search (LAS) detectors that achieve maximum likelihood detection in a subset of hypotheses whereas their expected per-bit computational complexity is linear in the number of users. The LAS detectors monotonically increase likelihood at every search step, and thus monotonically decrease error probability, and converge to a fixed point in a finite number of steps with probability one. It is proved that the thresholds set up in the LAS detectors are necessary and sufficient for monotonic likelihood ascent for an arbitrary signature crosscorrelation matrix with probability one. Among the LAS detectors, the set of wide-sense sequential LAS (WSLAS) detectors is shown to be a set of local maximum likelihood (LML) detectors defined with neighborhood size one. The properties of the fixed points and their observation regions are studied. Simulations are carried out and verify analytical results.
Cnvlutin: Ineffectual-Neuron-Free Deep Neural Network Computing (2016)

This work observes that a large fraction of the computations performed by Deep Neural Networks (DNNs) are intrinsically ineffectual as they involve a multiplication where one of the inputs is zero. This observation motivates Cnvolutin (CNV), a value-based approach to hardware acceleration that eliminates most of these ineffectual operations, improving performance and energy over a state-of-the-art accelerator with no accuracy loss. CNV uses hierarchical data-parallel units, allowing groups of lanes to proceed mostly independently enabling them to skip over the ineffectual computations. A co-designed data storage format encodes the computation elimination decisions taking them off the critical path while avoiding control divergence in the data parallel units. Combined, the units and the data storage format result in a data-parallel architecture that maintains wide, aligned accesses to its memory hierarchy and that keeps its data lanes busy. By loosening the ineffectual computation identification criterion, CNV enables further performance and energy efficiency improvements, and more so if a loss in accuracy is acceptable. Experimental measurements over a set of state-of-the-art DNNs for image classification show that CNV improves performance over a state-of-the-art accelerator from 1.24x to 1.55x and by 1.37x on average without any loss in accuracy by removing zero-valued operand multiplications alone. While CNV incurs an area overhead of 4.49%, it improves overall EDP (Energy Delay Product) and ED2P (Energy Delay Squared Product) on average by 1.47x and 2.01x, respectively. The average performance improvements increase to 1.52x without any loss in accuracy with a broader ineffectual identification policy. Further improvements are demonstrated with a loss in accuracy.
Spectroscopic signatures of the T to R conformational transition in the insulin hexamer (1989)

The cobalt(II)-substituted human insulin hexamer has been shown to undergo the phenol-induced T6 to R6 structural transition in solution. The accompanying octahedral to tetrahedral change in ligand field geometry of the cobalt ions results in dramatic changes in the visible region of the electronic spectrum and thus represents a useful spectroscopic method for studying the T to R transition. Changes in the Co2+ spectral envelope show that the aqua ligand associated with each tetrahedral Co2+ center can be replaced by SCN-, CN-, OCN-, N3-, Cl-, and NO2-. 19F NMR experiments show that the binding of m-trifluorocresol stabilizes the R6 state of zinc insulin. The chemical shift and line broadening of the CF3 singlet, which occur due to binding, provide a useful probe of the T6 to R6 transition. Due to the appearance of new resonances in the aromatic region, the 500 MHz 1H NMR spectrum of the phenol-induced R6 hexamer is readily distinguishable from that of the T6 form. 1H NMR studies show that phenol induces the T6 to R6 transition, both in the (GlnB13)6(Zn2+)2 hexamer and in the metal-free GlnB13 species; we conclude that metal binding is not a prerequisite for formation of the R state in this mutant.
Clinicopathological significance of ASC amino acid transporter‐2 expression in pancreatic ductal carcinoma (2014)

ASCT2 expression plays an important role in tumour cell growth, and is a promising pathological marker for predicting a worse outcome in pancreatic cancer.
Long Term Safety of Infliximab (2000)

Infliximab is a chimeric anti-tumour necrosis factor-alpha monoclonal antibody that has been studied for the treatment of Crohn's disease and rheumatoid arthritis. In several placebo controlled, randomized clinical trials and open trials, 771 patients have been given infliximab (a further 192 received placebo). Follow-up for safety has included the time of study (12 weeks after the last infusion), plus three additional years. Acute infusion reactions (headache, fever, chills, urticaria, chest pain) were seen in 17% of patients receiving infliximab compared with 7% of those receiving placebo. While infections were reported more frequently overall in the patients given infliximab (26% over 27 weeks of follow-up versus 16% of placebo-treated patients over 20 weeks of follow-up), there was no increased risk of serious infections. There was no difference in the overall mortality rate between the groups. While low titres of autoantibodies developed in less than 10% of patients, drug-induced lupus was seen in less than 1%, with these cases resolving upon discontinuation of the drug. Overall, infliximab showed an acceptable safety profile.
The effect of interferon alpha 2b on the expression of cytoskeletal proteins in an in vitro model of wound contraction. (1995)

Wound contraction is an essential component of wound healing. However, the development of scar contractures in tissues and organs disrupts normal organ integrity and produces functional deformities. Although interferons alpha and gamma inhibit extracellular matrix protein production by fibroblasts, their effects on cytoskeletal protein mediated-wound contraction are as yet unclear. The fibroblast-populated collagen lattice is an in vitro assay that simulates wound contraction. When matched pairs of human hypertrophic scar and normal dermal fibroblast cultures established from patients recovering from a thermal injury were used, interferon-alpha 2b exposure before lattice formation was found to significantly inhibit contraction in a treatment time-dependent manner (p < 0.05). Fibroblasts generated contractile forces that were triphasic and serum sensitive (p < 0.01). Comparison of hypertrophic scar and normal dermal fibroblasts revealed no significant differences in ability to induce lattice contraction. Northern blot analysis of mRNAs for the intracellular contractile proteins revealed that interferon-alpha 2b significantly down-regulated mRNA levels of the actin isoforms beta and gamma (50% to 60%) but had no significant effect on alpha-tubulin, vimentin, and alpha-actinin. Fibroblast-populated collagen lattices were stained with rhodamine-labeled phalloidin to reveal filamentous actin proteins. Marked morphologic alterations of the stress fibers were associated with reductions in lattice contraction after interferon-alpha 2b treatment. Thus interferon-alpha 2b's inhibition of wound contraction in vitro is associated with reductions in mRNA for beta and gamma actin and distinct morphologic alterations in fibroblast stress fiber morphology.
Web prefetching in a mobile environment (1998)

Prefetching is one of the most popular techniques for dealing with the slow access speed of the World Wide Web. To provide a mobile user with effective real time online prefetching requires that the prefetch decision is able to adapt to different network systems. This article describes an adaptive network prefetch scheme which accomplishes this task. The basic scheme is comprised of a prediction module and a threshold module, which computes the access probabilities and prefetch thresholds respectively. The access probabilities indicate how likely files will be requested by the user, and the prefetch thresholds determine whether the performance may be improved by prefetching certain files. As a user changes network in a mobile environment, it is the prefetch threshold, which is computed based on system conditions as well as the costs of bandwidth and time, that adjusts the number of prefetched files accordingly. In addition, by extending the method of computing the access probabilities, we are able to prefetch a group of files together for a user who is about to be disconnected from the network.
Gynecomastia and Breast Cancer during Finasteride Therapy (1996)

Antibody response to influenza
What Else is Revealed by Order-Revealing Encryption? (2016)

The security of order-revealing encryption (ORE) has been unclear since its invention. Dataset characteristics for which ORE is especially insecure have been identified, such as small message spaces and low-entropy distributions. On the other hand, properties like one-wayness on uniformly-distributed datasets have been proved for ORE constructions.
New Perspectives on the Role of Autonomic Nervous System in the Genesis of Arrhythmias (2006)

Sudden cardiac death (SCD) is a major cause of morbidity and mortality in patients with coronary artery diseases and myocardial infarction (MI). There is a circadian variation of the frequency of SCD. Beta-blocker therapy significantly reduces the incidence of SCD after MI. These clinical observations suggest a close association between ventricular arrhythmia and sympathetic activity in patients with MI. Following injury, peripheral nerves undergo Wallerian degeneration, which may be followed by neurilemma cell proliferation and axonal regeneration (nerve sprouting), resulting in sympathetic hyperinnervation. It is possible that the increased innervation after myocardial injury may result in increased sympathetic nerve density, which in turn increases the propensity for cardiac arrhythmia. While this Nerve Sprouting Hypothesis seemed to be intuitive, there was no experimental proof of a causal link between sympathetic nerve sprouting and arrhythmogenesis. We therefore performed several studies to determine the relationship between nerve sprouting and cardiac arrhythmia. We also performed direct sympathetic nerve recording in an animal model of SCD. We found that cardiac sympathetic nerves are highly plastic. In addition to MI and rapid pacing, nerve sprouting and heterogeneous sympathetic hyperinnervation may also be induced by radiofrequency ablation, hypercholesterolemia, and stem cells transplantation. The coexistence of denervated and hyperinnervated area in the diseased myocardium could result in increased electrophysiological heterogeneity during sympathetic activation, leading to ventricular arrhythmia and SCD.
Acquisition Using Simultaneous Sources (2007)

B006 Acquisition Using Simultaneous Sources J. Stefani* (Chevron Energy Technology Company) G. Hampson (Chevron Energy Technology Company) &amp; E.F. Herkenhoff (Chevron Energy Technology Company) SUMMARY We present a technique in which 2 or more shots are acquired during the time it normally takes to acquire 1 shot. The 2 or more shots are fired in a near simultaneous manner with small random time delays between the component sources. A variety of processing techniques are applied to produce the same seismic images which would have resulted from firing the simultaneous shots separately. These processing techniques rely on coherency of the wavefield
Development and testing of inorganic sorbents made by the internal gelation process for radionuclide and heavy metal separations (1995)

The objectives of this task are to develop, prepare, and test microspheres and granular forms of inorganic ion exchangers to remove radionuclides and heavy metals from waste streams occurring at various sites. Several inorganic materials, such as hexacyanoferrates, titanates, phosphates, and oxides have high selectivities and efficiencies for separating and removing radionuclides such as uranium, technetium, cesium, and strontium, and metals such as cobalt, silver, zinc, and zirconium from aqueous waste streams. However, these sorbents frequently exist only as powders and consequently are not readily adaptable to continuous processing such as column chromatography. Making these inorganic ion exchangers as microspheres or granular forms improves the flow dynamics for column operations and expands their practical applications. Microspheres of several materials have been prepared at ORNL, and the effectiveness of zirconium monohydrogen phosphate and hydrous titanium oxide microspheres for removing radionuclides from hot cell waste solutions has been demonstrated.
Molecular Genetics of Human Intracranial Aneurysms (2008)

Intracranial aneurysms (IAs) are the dilatations of blood vessels in the brain and pose potential risk of rupture leading to subarachnoid hemorrhage. Although the genetic basis of IAs is poorly understood, it is well-known that genetic factors play an important part in the pathogenesis of IAs. Therefore, the identifying susceptible genetic variants might lead to the understanding of the mechanism of formation and rupture of IAs and might also lead to the development of a pharmacological therapy. To elucidate the molecular pathogenesis of diseases has become a crucial step in the development of new treatment strategies. Although extensive genetic research and its potential implications for future prevention of this often fatal condition are urgently needed, efforts to elucidate the susceptibility loci of IAs are hindered by the issues bewildering the most common and complex genetic disorders, such as low penetrance, late onset, and uncertain modes of inheritance. These efforts are further complicated by the fact that many IA lesions remain asymptomatic or go undiagnosed. In this review, we present and discuss the current status of genetic studies of IAs and we recommend comprehensive genome-wide association studies to identify genetic loci that underlie this complex disease.
Identification of Hepatitis C Virus Genotypes among Hospitalized Patients in British Columbia, Canada (1995)

The distribution pattern of hepatitis C virus (HCV) genotypes among patients from British Columbia has been investigated by reverse transcription polymerase chain reaction (PCR) amplification of the 5' noncoding region (NCR) and direct DNA sequencing of the PCR product. The sequence data obtained from the British Columbia isolates were compared with HCV sequences for the NCR obtained from GenBank for the construction of a phylogenetic tree using the GDE program, version 2.2. The data show that in British Columbia there are 7 subtypes distributed among major genotypes 1, 2, and 3. The study also shows a new subtype of genotype 1 that represents 29% of the analyzed cases.
Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons (2014)

Production of mRNA depends critically on the rate of RNA polymerase II (Pol II) elongation. To dissect Pol II dynamics in mouse ES cells, we inhibited Pol II transcription at either initiation or promoter-proximal pause escape with Triptolide or Flavopiridol, and tracked Pol II kinetically using GRO-seq. Both inhibitors block transcription of more than 95% of genes, showing that pause escape, like initiation, is a ubiquitous and crucial step within the transcription cycle. Moreover, paused Pol II is relatively stable, as evidenced from half-life measurements at ∼3200 genes. Finally, tracking the progression of Pol II after drug treatment establishes Pol II elongation rates at over 1000 genes. Notably, Pol II accelerates dramatically while transcribing through genes, but slows at exons. Furthermore, intergenic variance in elongation rates is substantial, and is influenced by a positive effect of H3K79me2 and negative effects of exon density and CG content within genes.DOI: http://dx.doi.org/10.7554/eLife.02407.001.
Enzyme therapy: II. Effect of covalent attachment of polyethylene glycol on biochemical parameters and immunological determinants of beta-glucosidase and alpha-galactosidase. (1984)

The covalent attachment of polyethylene glycol (PEG) to beta-glucosidase from sweet almonds and alpha-galactosidase from green coffee beans results in alterations of their catalytic properties and masking of specific determinant sites on the enzymes. Both enzymes have increased Km and decreased Vmax values against their respective p-nitrophenyl substrate analogs after PEG attachment. When PEG is attached to 30% of alpha-galactosidase epsilon-amino groups, 12% activity remains against ceramide trihexoside, while its ability to convert type B erythrocytes to type H specificity is lost. However, it still is able to cleave terminal galactose residues from human saliva blood group substance B. PEG-beta-glucosidase (38%) did not elicit the production of complement-fixing antibodies, nor did it react with antibodies produced against the native enzyme. Antibody and lectin-specific binding were lost from both modified enzymes (PEG-beta-glucosidase and PEG-alpha-galactosidase). After conjugation with PEG, beta-glucosidase lost its ability to bind to concanavalin A-Sepharose. Antibodies directed against native alpha-galactosidase blocked its enzyme activity, but lost their ability to inhibit activity in progressively higher modified preparations of the enzyme. Antisera against PEG-alpha-galactosidase (53%) did not inhibit enzyme activity in any alpha-galactosidase or PEG-alpha-galactosidase preparation. These results indicate that PEG tends to cover lectin-specific carbohydrate moieties and antigenic determinants and that these sites probably remain cryptic during in vivo processing of PEG-enzymes.
Characterization of Cation-Binding Sequences in the Platelet Integrin GPIIb-IIIa (.alpha.IIb.beta.3) by Terbium Luminescence (1994)

The binding of cations to purified GPIIb-IIIa (alpha IIb beta 3) and synthetic peptides corresponding to the potential cation-binding sites within this integrin has been assessed by terbium luminescence spectroscopy. Tb3+ supported fibrinogen binding to purified GPIIb-IIIa, at lower concentrations than Ca2+, consistent with its higher affinity for cation-binding motifs. Titration analyses indicated the presence of five Tb(3+)-binding sites of relatively high affinity in the receptor. These sites also could be filled by divalent cations. Six sequences within GPIIb-IIIa have the appropriate spacing of five of the usual six coordination sites for cations in functional Ca(2+)-binding EF-hand motifs. Peptides containing Tyr and/or Trp at selected positions as fluorescence energy donors were synthesized, and their Tb(3+)-binding capacity was assessed. The four potential Ca(2+)-binding sequences in the GPIIb subunit, GPIIb 242-255, 296-309, 364-377, and 425-438, were functional, despite lacking the usual Glu residue at the terminal coordination position. These peptides bound Tb3+ with the same affinity as typical Ca(2+)-binding loop peptides and also bound Ca2+ and other divalent cations without preference. Of the two candidate GPIIIa sequences, 118-131 and 208-221, the former bound Tb3+ and divalent cations with an affinity similar to that of the GPIIb peptides, whereas the latter peptide was not functional. This functional difference, as well as data obtained with substituted peptides, emphasizes the importance of the first coordination position for interaction of synthetic peptide loops with cations. Together, these data identify the five cation-binding sites within intact GPIIb-IIIa.
Studies on Reduced Wool I. The Extent of Reduotion of Wool with Inoreasing Conoentrations of Thiol, and the Extraotion of Proteins from Reduoed and Alkylated Wool (1962)

The reduction of wool with mercaptoethanol and thioglycollate at pH 5 has been compared by measuring the disulphide contents of the reduced wool after alkylation of the thiol groups with iodoacetate at pH 8·5--9. Mercaptoethanol and thioglycollate are very similar in their extent of reduction of wool at low concentrations of thiol but the neutral thiol is more effective as a reducing agent at high concentrations. In contrast with the earlier findings of Patterson et al.
Regeneration of Sulfided Dolomite with Steam and Carbon Dioxide (2000)

The regeneration process of a sulfided dolomite with steam and carbon dioxide was analyzed in a thermogravimetric system at temperatures between 475 and 650 °C. Different gas concentrations from 5 to 40% and different H2O/CO2 ratios were used to isolate the effect of the different gases on the regeneration process. The morphological changes of the sorbent during regeneration and cyclic sulfidation/regeneration reactions were followed by SEM-EDX analysis, which indicated a grain structure inside the particle. The changing grain size model with a variable diffusivity in the CaCO3 product layer was used to predict the experimental data, and to obtain the kinetic parameters of the regeneration reaction. The sintering of the CaCO3 has showed to be responsible of the changes in the solid diffusivity along the time, the H2O being the more important sintering agent on the process. Finally, the dolomite was subject to the calcination/sulfidation/regeneration process during 20 cycles and no activity loss was detected along the successive cycles.
Surface-gradient cross-linked polyethylene acetabular cups: oxidation resistance and wear against smooth and rough femoral balls. (2005)

Two methods were developed and evaluated for cross-linking the bearing surface of a polyethylene acetabular cup to a limited depth, in order to improve its resistance to wear without degrading the mechanical properties of the bulk of the component. In the first method, low-energy electron beams were used to cross-link only the bearing surface of the cups to a maximum depth of about 2 mm. The cups then were annealed at 100 degrees C in vacuum for 3 or 6 days to reduce the residual free radicals, and the resultant resistance to oxidation was compared by artificially aging the cups at 80 degrees C in air. Chemically cross-linked surface layers were produced by coating the bearing surfaces of the cups with a thin layer of polyethylene powder mixed with 1% weight peroxide, and compressing them at 6.9 MPa (1000 psi) and 170 degrees C. This resulted in a cross-linked surface layer that extended about 3 mm deep, with a gradual transition to conventional (noncross-linked) polyethylene in the bulk of the implant. In hip simulator wear tests with highly polished (implant quality) femoral balls, both types of surface cross-linking were found to improve markedly the wear resistance of the acetabular cups. In tests with roughened femoral balls, the wear rates were much higher and were comparable to those obtained with similarly roughened balls against noncross-linked polyethylene cups in a previous study, indicating that the full benefit of cross-linking may not be realized under conditions of severe third-body abrasion. Nevertheless, these results show a promising approach for optimizing the wear resistance and the bulk mechanical properties of polyethylene components in total joint arthroplasty.