gebhart/patrepeval huggingface dataset:
Interactions between growth factor receptors and corresponding monoclonal antibodies in human tumors (1987)

Monoclonal antibodies (MAbs) to the human epidermal growth factor (EGF) receptor, the type I insulin-like growth factor (IGF) receptor, and the nerve growth factor (NGF) receptor were used to study the growth regulation of malignant cells. Anti-EGF receptor MAb 425 inhibited the growth of A 431 squamous carcinoma cells which express high numbers of EGF receptors on their surfaces. Growth inhibition induced by MAb 425 was accompanied by alterations of the cell-cycle distribution of these cells, indicating the ability of a monoclonal antibody to act as a biologically active ligand. Growth stimulation of melanoma cells by EGF was unrelated to EGF receptor expression on the cell surface. Insulin- and IGF-I-induced growth stimulation of melanoma cells was inhibited by MAb alpha IR-3 which reacts with the type I IGF receptor. This result indicates that the type I IGF receptor mediated growth stimulation not only by IGF-I but also by insulin. Normal melanocytes and cells of all stages of tumor progression expressed in tissue culture the receptor for NGF, but no effect on the growth of these cells has been observed.
Antigen Retrieval Immunohistochemistry: Past, Present, and Future (1997)

The antigen retrieval (AR) technique, which is predominantly based on high-temperature heating of tissues, is used as a non-enzymatic pretreatment for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections. It has been widely applied in pathology and analytical morphology. The existence of a growing body of literature on the AR technique raises a number of interesting issues for the further development of AR. These issues include the use of a "test battery" and the concept of "maximal retrieval" applied to the selection of optimal test protocols for the standardization of AR.
Multiplex PCR for Simultaneous Identification of Staphylococcus aureus and Detection of Methicillin and Mupirocin Resistance (2001)

In this work, we describe a multiplex PCR assay for the detection of clinically relevant antibiotic resistance genes harbored by some Staphylococcus aureus isolates and for the simultaneous identification of such isolates at the species level. Conditions were optimized for the simultaneous detection of the 310-, 456-, and 651-bp regions of the mecA (encoding high-level methicillin resistance), ileS-2 (encoding high-level mupirocin resistance), and femB (encoding a factor essential for methicillin resistance) genes, respectively, from a single colony in a single reaction tube. The femB PCR fragment allows the specific identification of S. aureus. Validation of the method was performed using 50 human isolates of methicillin-resistant S. aureus (MRSA) and the appropriate control strains. This assay offers a rapid, simple, feasible, specific, sensitive, and accurate identification of mupirocin-resistant MRSA clinical isolates and could be systematically applied as a diagnostic test in clinical microbiology laboratories, facilitating the design and use of antibiotic therapy.
Efficacy and safety of ferric carboxymaltose versus ferrous sulfate for iron deficiency anemia during pregnancy: subgroup analysis of Korean women (2018)

FCM provided significantly greater improvements in iron parameters and QoL compared to FS in the Korean subgroup. FCM may be a preferable alternative to currently available treatments for IDA during pregnancy.
A comparison of DFT and DWT based similarity search in time-series databases (2000)

Article A comparison of DFT and DWT based similarity search in time-series databases Share on Authors: Yi-Leh Wu Department of Computer Science, University of California, Santa Barbara Department of Computer Science, University of California, Santa BarbaraView Profile , Divyakant Agrawal Department of Computer Science, University of California, Santa Barbara Department of Computer Science, University of California, Santa BarbaraView Profile , Amr El Abbadi Department of Computer Science, University of California, Santa Barbara Department of Computer Science, University of California, Santa BarbaraView Profile Authors Info & Claims CIKM '00: Proceedings of the ninth international conference on Information and knowledge managementNovember 2000 Pages 488–495https://doi.org/10.1145/354756.354857Online:06 November 2000Publication History 144citation1,836DownloadsMetricsTotal Citations144Total Downloads1,836Last 12 Months91Last 6 weeks11 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
A Promising New Wideband Multiple‐Access Scheme for Future Mobile Communications Systems (1999)

Abstract Recently, “Interleaved Frequency‐Division Multiple‐Access” (IFDMA) has been introduced as a new spread‐spectrum multiple‐access scheme for mobile communications which is suitable for both downlink and uplink applications. IFDMA combines spread‐spectrum multicarrier transmission with frequency‐division multiple‐access and, therefore, is capable of achieving frequency diversity while multiple‐access interference is avoided. Moreover, compared to other wideband multiple‐access schemes IFDMA shows several additional advantages. The cost to achieve these advantages is to allow for intersymbol interference. However, the effects of intersymbol interference can be reduced significantly by applying an equalizer at the IFDMA receiver. In this paper, the principle of IFDMA is reviewed and it is shown that IFDMA is a promising new wideband multiple‐access scheme suitable for future mobile communications systems. The frequency diversity achievable with IFDMA is determined as well as performance results for uncoded and coded transmission taking into account different equalization techniques. As a result, uncoded IFDMA applying optimum equalization performs even better than uncoded multicarrier code‐division multiple‐access applying maximum‐likelihood multi‐user detection. In the case of coded IFDMA transmission coding gains up to 6.8 dB at a bit‐error‐rate of 10 − ‐ 4 are achieved using a standard convolutional code. An additional performance gain of up to 2.2 dB is possible if equalization and decoding are considered jointly.
Rod-Cone Dysplasia in Irish Setters: A Defect in Cyclic GMP Metabolism in Visual Cells (1978)

An abnormality in retinal guanosine 3,5-monophosphate (cyclic GMP) metabolism is demonstrated in the inherited rod-cone dysplasis of Irish Setter dogs. Affected visual cells are deficient in cyclic GMP phosphodiesterase activity and have elevated levels of cyclic GMP. The biochemical abnormalities observed in affected retinas of Irish Setters are similar to those in the retinas of mice with inherited retinal degeneration before visual cell degeneration begins. A defect in cyclic GMP metabolism may be characteristic of early-onset degenerative diseases of the retina, possibly including those that affect humans.
Camera-based observation of football games for analyzing multi-agent activities (2006)

This paper describes a camera-based observation system for football games that is used for the automatic analysis of football games and reasoning about multi-agent activity. The observation system runs on video streams produced by cameras set up for TV broadcasting. The observation system achieves reliability and accuracy through various mechanisms for adaptation, probabilistic estimation, and exploiting domain constraints. It represents motions compactly and segments them into classified ball actions.
Study of Novel Channel Materials Using III-V Compounds with Various Gate Dielectrics (2013)

The exponential rise in the density of silicon CMOS transistors has now reached a limit and threatening to end the microelectronics revolution. To tackle this difficulty, group III–V compound semiconductors due to their outstanding electron transport properties and high mobility are very actively being researched as channel materials for future highly scaled CMOS devices. In this paper, we have studied a ballistic nanoscale MOSFET using simulation approach by replacing silicon in the channel by III-V compounds. The channel materials considered are silicon (Si), Gallium arsenide (GaAs), Indium arsenide (InAs), Indium Phosphide (InP) and Indium Antimonide (InSb). The device metrics considered at the nanometer scale are subthreshold swing, Drain induced barrier lowering, on and off current, carrier injection velocity and switching speed. These channel materials have been studied using various dielectric constants. It has been observed that Indium Antimonide (InSb) has higher on current, higher transconductance, idealistic subthreshold swing, higher output conductance, higher carrier injection velocity and comparable voltage gain compared to Silicon, thus, making InSb as a possible candidate to be used as channel material in future nanoscale devices. <br>
TLR4/MyD88/PI3K interactions regulate TLR4 signaling (2009)

TLRs activate immune responses by sensing microbial structures such as bacterial LPS, viral RNA, and endogenous "danger" molecules released by damaged host cells. MyD88 is an adapter protein that mediates signal transduction for most TLRs and leads to activation of NF-kappaB and MAPKs and production of proinflammatory cytokines. TLR4-mediated signaling also leads to rapid activation of PI3K, one of a family of kinases involved in regulation of cell growth, apoptosis, and motility. LPS stimulates phosphorylation of Akt, a downstream target of PI3K, in wild-type (WT) mouse macrophages. LPS-induced phosphorylation of Akt serine 473 was blunted in MyD88(-/-) macrophages and was completely TLR4-dependent. MyD88 and p85 were shown previously to co-immunoprecipitate, and a YXXM motif within the Toll-IL-1 resistance (TIR) domain of MyD88 was suggested to be important for this interaction. To test this hypothesis, we compared expressed MyD88 variants with mutations within the YXXM motif or lacking the TIR domain or death domain and measured their capacities to bind PI3K p85, MyD88, and TLR4 by co-immunoprecipitation analyses. The YXXM --> YXXA mutant MyD88 bound more strongly to p85, TLR4, and WT MyD88 than the other variants, yet was significantly less active than WT MyD88, suggesting that sustained interaction of MyD88/PI3K with the TLR4 intracellular "signaling platform" negatively regulates signaling. We propose a hypothetical model in which sustained PI3K activity at the membrane limits the availability of the PI3K substrate, thereby negatively regulating signaling.
Receptor-mediated calcium signalling in glial cells from mouse corpus callosum slices (1996)

We addressed the question of whether glial cells in intact white matter tracts express neurotransmitter receptors and we used Ca+2 signalling as a probe to detect the receptor activation. Corpus callosum slices from postnatal mice were bulk-loaded with the Ca+2-sensitive fluorescent dye fluo-3, and confocal microscopy was used to measure Ca+2 transients in response to neuroligands. Glial cell bodies were intensely dye-loaded and could be discriminated from the diffuse fluorescence of axons. Subpopulations of glial cells from slices obtained at postnatal days 3 to 7 responded with Ca+2 signals to ATP, glutamate, histamine, GABA, norepinephrine, serotonin, angiotensin II, bradykinin, and substance P. These subpopulations showed a distinct overlap; cells which were responsive to substance P always showed Ca+2 signalling in response to histamine, ATP, GABA and high K+ (membrane depolarization). GABA-responsive cells almost always showed a [Ca+2]i increase after membrane depolarization. In brain slices from postnatal day 11 to 18 animals, the Ca+2 responses were evident for glutamate, ATP, and norepinephrine, while GABA, substance P, serotonin, histamine, or angiotensin II rarely elicited a response. This study demonstrates that white matter glial cells in slices exhibit a large repertoire of neurotransmitter responses linked to Ca+2 signalling and that these receptor systems are differentially distributed on sub-populations of glial cells.
A frequent DHFR polymorphism detected by an intron fragment (1989)

The DHFR probe is a 315 bp intron fragment located between exons 1 and 2. It is subcloned at the EcoRI and HindIII sites of pUC9 (1). POLYMORPHISM: RsaI identifies two allelic bands at 1.7 kb and 0.85 kb. No other bands are detected. This probe detects a polymorphism distinct from that which has been reported previously (2). FREOUENCY: As determined from 19 unrelated North American Caucasians.
Synthesis of Anti‐Inflammatory α‐Arylalkanoic Acids by 1,2‐Aryl Shift. New Synthetic Methods (42) (1984)

Abstract α‐Arylalkanoic acids have acquired importance as anti‐inflammatory agents and are now in great demand on the pharmaceutical front. Hence, the need has arisen for new and improved, economical synthetic procedures suitable for their preparation and manufacture on an industrial scale. For many years the synthetic approach to this class of compounds was restricted to the Willgerodt and Darzen reactions. More recently, several methods have been developed which are based on the 1,2‐aryl shift in acetals of α‐functionalized alkyl aryl ketones. This new approach starts from the oxythallation of alkyl aryl ketones first described by Taylor and McKillop in 1971. Asymmetric syntheses of some important arylakanoic acids have also been developed on this basis. The highly toxic thallium salts may be replaced, inter alia, by catalytically effective metal salts.
IPv6-based dynamic coordinated call admission control mechanism over integrated wireless networks (2005)

Many wireless access systems have been developed recently to support users mobility and ubiquitous communication. Nevertheless, these systems always work independently and cannot simultaneously serve users properly. In this paper, we aim to integrate IPv6-based wireless access systems and propose a coordinated call admission control mechanism to utilize the total bandwidth of these systems to minimize the call blocking probabilities, especially the handoff call dropping probabilities. First, we propose an integrated hierarchical wireless architecture over IPv6-based networks to combine the wireless access systems including cellular systems (second-generation, General Packet Radio Service, or third-generation), IEEE 802.11 a/b/g WLAN, and Bluetooth. In the proposed architecture, mobile user can request a call with quality-of-service (QoS) requirements by any wireless network interfaces that can be accessed. When the proposed coordinated call admission control (CCAC) mechanism receives a request, it takes the QoS requirements of the incoming call and the available and reserved bandwidth of this wireless system into consideration to accept or reject this request. Besides, the mechanism can coordinate with other wireless systems dynamically to adjust the bandwidth reserved for handoff calls at each wireless system in this architecture so as to reduce the call blocking probabilities. Once the call is admitted, the mobile user is able to access heterogeneous wireless access networks via multiple interfaces simultaneously. Finally, we evaluate this system to show that the CCAC on the proposed architecture outperforms other mechanisms proposed before.
ERK and p38 mediate high-glucose-induced hypertrophy and TGF-β expression in renal tubular cells (2004)

We investigated the expression of ERK, p38 mitogen-activated protein kinase (p38), and JNK in renal tubules of diabetic rats following 3 wk after streptozotocin injection (DM). Although the expression of ERK was not different between controls and DM, phosphorylated ERK was expressed more intensely in DM. p38 And phosphorylated p38 were detected only in the diabetic kidney and were localized in all tubular segments. JNK and phosphorylated JNK were expressed similarly in controls and DM. Transforming growth factor (TGF)-β was expressed in all tubular segments of DM, coinciding with the localization of p38. In LLC-PK 1 cells, phosphorylation of ERK and p38 increased after 24- to 72-h exposure to high glucose (HG). Coincubation with a p38 inhibitor SB-203580 or a MEK inhibitor, PD-98059, suppressed the HG-induced increases in protein content, [ 3 H]leucine incorporation, and the protein-to-DNA ratio. SB-203580 or PD-98059 also abolished the HG-stimulated expression of TGF-β protein. These results demonstrate that ERK and p38 are activated in renal tubular cells of DM and may mediate HG-induced cellular hypertrophy and TGF-β expression.
Buffer-constrained R-D Model-Based Rate Control for H.264/AVC (2006)

Most existing R-D model based rate control schemes are not applicable in H.264/AVC due to the unique features of H.264/AVC, for example, the QP-dependent rate distortion optimization (RDO); the large number of bits (header bits) used for encoding the header information (except DCT coefficients) of a macroblock (MB); the huge number of zero-coefficient MBs. We present an R-D model based rate control scheme for H.264/AVC. A pre-analysis is conducted for R-D estimation. A rate model is developed to estimate the coefficient bits and the header bits separately. A frame-level bit allocation scheme is proposed. In comparison with JM6.1e, our scheme not only evidently improves the PSNR of decoded video (an average 0.54 dB PSNR gain is achieved for 7 sequences tested) but also meets the target bit rates accurately (within 2%).
Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow (1998)

Expression of the 210-kD bcr/abl fusion oncoprotein can cause a chronic myelogenous leukemia (CML)-like disease in mice receiving bone marrow cells transduced by bcr/abl-encoding retroviruses. However, previous methods failed to yield this disease at a frequency sufficient enough to allow for its use in the study of CML pathogenesis. To overcome this limitation, we have developed an efficient and reproducible method for inducing a CML-like disease in mice receiving P210 bcr/abl-transduced bone marrow cells. All mice receiving P210 bcr/abl-transduced bone marrow cells succumb to a myeloproliferative disease between 3 and 5 weeks after bone marrow transplantation. The myeloproliferative disease recapitulates many of the hallmarks of human CML and is characterized by high white blood cell counts and extensive extramedullary hematopoiesis in the spleen, liver, bone marrow, and lungs. Use of a retroviral vector coexpressing P210 bcr/abl and green fluorescent protein shows that the vast majority of bcr/abl-expressing cells are myeloid. Analysis of the proviral integration pattern shows that, in some mice, the myeloproliferative disease is clonal. In multiple mice, the CML-like disease has been transplantable, inducing a similar myeloproliferative syndrome within 1 month of transfer to sublethally irradiated syngeneic recipients. The disease in many of these mice has progressed to the development of acute lymphoma/leukemia resembling blast crisis. These results demonstrate that murine CML recapitulates important features of human CML. As such, it should be an excellent model for addressing specific issues relating to the pathogenesis and treatment of this disease.
Imine Additions of Internal Alkynes for the Synthesis of Trisubstituted (E)‐Alkene and Cyclopropane Peptide Isosteres (2005)

Abstract Divergent multi‐component reactions (DMCR) involving CC bond formations can provide large increases in structural diversity and allow the rapid assembly of complex products from readily available starting materials. Cascade hydrozirconation‐Zr/Zn transmetalation‐imine addition of alkynes represents a versatile methodology for the synthesis of ( E )‐alkene and cyclopropane dipeptide isosteres. Appropriate substitutions at the sp 2 ‐carbon of ( E )‐alkene peptide isosteres allow a range of Pd‐catalyzed cross‐coupling reactions, which can be used for the fine‐tuning of the conformational and electronic properties of the parent peptide bond mimic. CC bond formation by microwave‐accelerated Stille coupling of stannylalkenes represents a fast, convergent synthetic approach toward trisubstituted ( E )‐alkene dipeptide isosteres.
The Dual Phases of the Response to Neonatal Exposure to a VH Family-Restricted Staphylococcal B Cell Superantigen (1998)

In vitro studies of several naturally occurring proteins have characterized VH family-specific B lymphocyte binding and stimulatory properties that appear analogous to those of T cell superantigens. To examine the in vivo consequences of exposure to a putative B cell superantigen, we treated neonatal BALB/c mice with a form of staphylococcal protein A (MS) devoid of Fcgamma binding activity, which retains the clan VHIII Fab binding specificity. In naive adults, about 5% of peripheral B cells and >13% of splenic IgM-secreting cells display MS binding activity, in association with high IgM and low IgG circulating anti-MS Ab titers. Neonatal exposure to MS elicited two distinct temporal phases of immune responsiveness. The early phase, representing the first approximately 5 wk of life, was associated with MS-specific B cell and T cell tolerance. Microfluorometric assays revealed that exposure caused a dramatic MS-specific B cell clonal loss in bone marrow and spleen, but levels normalized by about 3 wk of life. The late phase (>6 wk of age) was associated with spontaneous priming for MS-specific T cell responses and production of MS-specific IgG1 Abs despite long term persistently depressed in vivo and in vitro MS-specific IgM responses. In vivo challenge during the late phase induced high frequencies of MS-specific IgG-secreting cells, indicating recruitment of highly focused Ab responses that were predominantly encoded by rearrangements of the S107 family, a member of the VHIII clan. These studies document the immunodominance of the VH-restricted Fab binding site on staphylococcal protein A and demonstrate the diverse effects of a B cell superantigen on the emerging peripheral B cell compartment.
BCAR1, a Human Homologue of the Adapter Protein p130Cas, and Antiestrogen Resistance in Breast Cancer Cells (2000)

Overexpression of the BCAR1 gene confers antiestrogen resistance on human ZR-75-1 breast cancer cells. Overexpression of BCAR1 in retrovirus-mutated cells appears to result from activation of the gene's promoter. The isolation and characterization of this gene open new avenues to elucidating mechanisms by which the growth of human breast cancer becomes independent of estrogen.