gebhart/patrepeval huggingface dataset:
Pathfinding by neuronal growth cones in grasshopper embryos. III. Selective affinity of the G growth cone for the P cells within the A/P fascicle (1984)

The growth cone of the G neuron selectively fasciculates upon specific axon bundles in a stereotypic sequence as it navigates through the developing central nervous system of the grasshopper embryo. It turns and extends anteriorly in the contralateral neuropil of the second thoracic ganglion at a specific choice point where it fasciculates with the A/P axon bundle which contains the axons of the A1, A2, P1, and P2 neurons. We previously hypothesized (Raper, J. A., M. J. Bastiani, and C. S. Goodman (1983) J. Neurosci. 3: 20-41) that this fascicle, or subsets of axons within it, were specifically labeled and that the G neuron was determined to follow this labeled pathway. Here we report on an ultrastructural analysis of the interactions between the G growth cone and its filopodia with the cells of the A/P fascicle at the choice point. As G reaches its choice point, its filopodia are in more frequent contact with the A/P fascicle in comparison to the other longitudinal axon fascicles. Within the A/P fascicle, the tip of G's growth cone is found to be closely associated with the P and not the A axons. Furthermore, before the G growth cone climbs onto the A/P fascicle, its filopodia show a selective affinity for the P axons as compared to the A axons. Another specific interaction involves selective filopodial insertions; only filopodia from the P cells were found to insert into the G growth cone and induce coated pits and vesicles. These findings suggest that G is able to distinguish the A/P fascicle from other axon bundles and, moreover, is able to distinguish the P axons from the A axons. The companion paper (Raper, J. A., M. J. Bastiani, and C. S. Goodman (1984) J. Neurosci. 4: 2329-2345) presents experimental results based on specific axon ablations that further support this hypothesis.
Induction of Tolerance through Mixed Chimerism (2014)

"Mixed chimerism" refers to a state in which the lymphohematopoietic system of the recipient of allogeneic hematopoietic stem cells comprises a mixture of host and donor cells. This state is usually attained through either bone marrow or mobilized peripheral blood stem cell transplantation. Although numerous treatment regimens have led to transplantation tolerance in mice, the induction of mixed chimerism is currently the only treatment modality that has been successfully extended to large animals and to the clinic. Here we describe and compare the use of mixed chimerism to establish transplantation tolerance in mice, pigs, monkeys, and in the clinic. We also attempt to correlate the mechanisms involved in achieving tolerance with the nature of the tolerance that has resulted in each case.
NT-proBNP and the Diagnosis of Heart Failure: A Pooled Analysis of Three European Epidemiological Studies (2004)

Many studies have shown that the B-type natriuretic peptides (BNP and NT-proBNP) are proven diagnostic markers for heart failure due to left ventricular systolic dysfunction. The manner in which they are to be used is still being unravelled; most single centre studies have chosen the best concentration of the peptide on ROC analysis as their cut-point resulting in numerous different values for both BNP and NT-proBNP appearing in the literature. We report a different approach of defining an age and sex corrected abnormal concentration for NT-proBNP, derived from normal individuals within a large sample of 3051 subjects pooled from three European epidemiology studies and applying that to the entire population to detect HF and LVD. Three thousand and fifty one subjects were studied. Of these 10% (305) had significant LVD and 3.1% (94) had HF. The median concentrations of NT-proBNP (IQR) in normals, those with LVD and in heart failure subjects were 20 pg/ml (10.30), 117.3 pg/ml (28.145) and 269.6 pg/ml (54.323), P<0.001, respectively. The area under the ROC curve for NT-proBNP for the detection of 'heart failure' was 0.85 and 0.69 for LVD. NT-proBNP was an independent predictor of the presence of HF on multivariate analysis. An abnormal NT-proBNP was defined as being >95th centile for normals, age and sex corrected, and diagnosed HF with a sensitivity of 75% and a negative predictive value of 99%. In an additional analysis in a breathless subgroup of our population, in 30% a raised NT-proBNP concentration could be explained by HF due to LVD, in another 64% the high BNP level was associated with some other structural of functional cardiac abnormality or renal impairment. We were unable to assign a possible cause to the high NT-proBNP values in 5.9% of this breathless subgroup of the population. An abnormal NT-proBNP concentration is an accurate diagnostic test both for the exclusion of HF in the population and in ruling out LVD in breathless subjects. An elevated NT-proBNP merely indicates the presence of 'cardio-renal distress' and should prompt referral for further investigation.
Human peripheral blood monocytes secrete a unique form of PDGF. (1988)

PDGF isolated from platelets and forms of PDGF produced by cells transformed with the v-sis gene (PDGF B chain) or U-20S osteosarcoma cells which express the PDGF A chain gene are known to be processed as disulfide-linked dimers of approximately 30 kd. Western blot analysis with anti human PDGF antibody of the PDGF-like factor synthesized and secreted by human blood monocytes (MDGF) on SDS gels indicates that it lacks interchain disulfide bridges and behaves as a 16-kd monomer under nonreducing conditions. Additionally, MDGF exhibits different sensitivities to either formic acid or CNBr cleavage compared to PDGF A or B chain molecules indicating it may have a different primary structure. These data suggest that MDGF represents a unique form of PDGF which lacks interchain disulfide bridges and may represent a new member of the PDGF family of growth factors.
Recombination and loss analysis in polythiophene based bulk heterojunction photodetectors (2002)

The monochromatic external quantum efficiency of a bulk heterojunction photodetector based on a blend of poly-3(hexylthiophene) with a methanofullerene is reported to be as high as 76% at the peak maximum at 25 °C. Analysis of the temperature dependence, the illumination intensity dependence together with absorption measurements in reflection geometry, allow calculation of the internal quantum efficiency of the device close to 100% at the peak maximum. Recombination of photoinduced carriers is negligible or even absent in these photodetectors when operated in the photovoltaic mode. Optical losses in these bulk heterojunction devices are analyzed.
Getting More out of a Job Plot: Determination of Reactant to Product Stoichiometry in Cases of Displacement Reactions and n:n Complex Formation (2011)

The method of continuous variation (often referred to as Job's method) is an easy and common method for the determination of the reactant stoichiometry of chemical equilibria. The traditional interpretation of Job plots has been limited to complex association equilibria of the type nA + mB ⇌ A(n)B(m), while little focus has been placed upon displacement type reactions (e.g., A + B ⇌ C + D), which can give Job plots that look quite similar. We developed a novel method that allows the user to accurately distinguish between 1:1 complex association, 2:2 complex association, and displacement reactions using nothing more than a pocket calculator. This method involves preparing a Job plot of the system under investigation (using regularly spaced mole fractions), normalizing the measured quantities (such as the concentration of A(n)B(m) or C for the above reactions) to their maximum value (i.e., at mole fraction 0.5), and determining the sum of the normalized values. This sum is then compared with theoretically predicted normalized sum values that depend on the nature of the equilibrium. The relationship between, on the one hand, the sum of the normalized values and, on the other hand, the reaction equilibrium constant and the concentration of the stock solutions used for the preparation of the Job plot is also explored. The use of this new technique for the interpretation of Job plots permits users to readily determine information that can be obtained otherwise only with laborious additional experiments, as illustrated by the analysis of four Job plots taken from the literature.
Intracavernous Injection of Prostaglandin E1 for the Treatment of Erectile Impotence (1989)

We administered intracavernous injections of 20 micrograms. prostaglandin E1 to 135 patients with impotence, and evaluated the effects and side effects. Among 135 patients who underwent intracavernous injection of prostaglandin E1 complete erection was observed in 83 (62 per cent), while incomplete erection was noted in 33 (24 per cent). In both groups the erection was sufficient for sexual intercourse. Tumescence without rigidity was noted in 12 patients and no response was obtained in 7. Poor response was seen frequently in patients with disorders of the vascular system and/or damage to the cavernous body of the penis. Priapism after the injection was not observed. Moreover, we never observed any other severe side effects. Intracavernous injection of prostaglandin E1 could be applicable to the therapy of impotence, especially that due to neurogenic disturbance. Since prostaglandin E1 acts quickly and loses its validity rapidly it is considered to be a more suitable agent than other vasoactive drugs.
Mutations of adenomatous polyposis coli and beta-catenin genes during progression of lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine in rats. (2000)

In the present study, we investigated mutations of the adenomatous polyposis coli (APC) and beta-catenin genes to clarify possible molecular mechanisms underlying development of lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in rats. Male Wistar rats, 6 weeks of age, were given 2000 ppm BHP in drinking water for 12 weeks and then maintained without further treatment until sacrifice at week 25 DNA was extracted from paraffin-embedded tissues, and PCR-single-strand conformation polymorphism analysis, followed by nucleotide sequencing, was performed. No APC mutations were detected in 17 hyperplasias, but 2 of 15 adenomas (13.3%) and 8 of 20 adenocarcinomas (40.0%) showed changes within exon 1 to the mutation cluster region in exon 15. For beta-catenin, no mutations were detected in 17 hyperplasias, but 3 of 15 adenomas (20.0%) and 5 of 20 adenocarcinomas (25.0%) had alterations within or flanking codons corresponding to important phosphorylation sites. Immunohistochemical staining showed beta-catenin protein localized in the cell membranes in the surrounding normal-appearing lung and 216 hyperplasias and localized mainly in the cytoplasm and/or nucleus in 10 of 37 adenomas (27.0%) and 21 of 40 adenocarcinomas (52.5%). These results suggest that the APC-beta-catenin-T-cell factor signaling pathway is involved in the acquisition of growth advantage from adenomas to adenocarcinomas in BHP-induced rat lung carcinogenesis.
QuPath: Open source software for digital pathology image analysis (2017)

QuPath is new bioimage analysis software designed to meet the growing need for a user-friendly, extensible, open-source solution for digital pathology and whole slide image analysis. In addition to offering a comprehensive panel of tumor identification and high-throughput biomarker evaluation tools, QuPath provides researchers with powerful batch-processing and scripting functionality, and an extensible platform with which to develop and share new algorithms to analyze complex tissue images. Furthermore, QuPath's flexible design makes it suitable for a wide range of additional image analysis applications across biomedical research.
Stretch Genes (1997)

Polymers—macromolecules composed of many small molecules—are vital to life. For example, proteins provide the cell with structure and carry out its mechanical and enzymatic work. Fatty acids store energy in their bonds, and lipids form the membranes that seal off the cell's aqueous interior from its aqueous exterior. Heredity lies in the very long polymeric strands of deoxyribonucleic acid—DNA.
Use of speech recognition in computer-assisted language learning (2000)

inear Model Combination and Model Merging. These algorithms are based on the assumption that the mother-tongue of a non-native speaker is known. The basic idea underlying most ndings of this thesis is that non-native speech can be modeled with a mixture of sounds of a speaker&amp;apos;s native language and the target language. The newly developed speaker adaptation algorithms combine the acoustic models of the source and target language of a nonnative speaker. The algorithms only dier with regard to the details how the model sets are combined. A database of non-native English was recorded for the purpose of testing these adaptation algorithms. This database mostly consists of utterances of Japanese and Latin-American Spanish accented English. The recordings were transcribed by trained phoneticians to obtain transcriptions corresponding to the actual phoneme sequence uttered by the student as opposed to canonical transcriptions obtained ii iii from a standard
Cyclin E2 induces genomic instability by mechanisms distinct from cyclin E1 (2013)

Cyclins E1 drives the initiation of DNA replication, and deregulation of its periodic expression leads to mitotic delay associated with genomic instability. Since it is not known whether the closely related protein cyclin E2 shares these properties, we overexpressed cyclin E2 in breast cancer cells. This did not affect the duration of mitosis, nor did it cause an increase in p107 association with CDK2. In contrast, cyclin E1 overexpression led to inhibition of the APC complex, prolonged metaphase and increased p107 association with CDK2. Despite these different effects on the cell cycle, elevated levels of either cyclin E1 or E2 led to hallmarks of genomic instability, i.e., an increased proportion of abnormal mitoses, micronuclei and chromosomal aberrations. Cyclin E2 induction of genomic instability by a mechanism distinct from cyclin E1 indicates that these two proteins have unique functions in a cancer setting.
Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation (2011)

We investigated the efficacy of the antihypertensive drug telmisartan (Tel) and the mechanisms underlying the progression from simple steatosis to nonalcoholic steatohepatitis (NASH) in a medaka (Oryzias latipes) NASH model. We used the NASH activity score (NAS) developed in humans to assess the histology of the medaka NASH model and found that NAS increased with time. Further, TUNEL-positive apoptosis hepatocytes were found in the medaka NASH model. Tel administration resulted in the increased expression of liver peroxisome proliferator-activated receptor-γ, carnitine palmitoyltransferase 1 and acyl-CoA oxidase 1 and decreased the number of 8-hydroxydeoxyguanosine-positive hepatocytes and the migration of macrophages positive for diastase-periodic-acid-Schiff. Medaka NAS was improved by Tel administration but fatty acid content was not affected. Tel reduced the infiltration of macrophages into the liver and ameliorated NASH pathology.
Antibiotic Susceptibility Profiles of Escherichia coli Strains Lacking Multidrug Efflux Pump Genes (2001)

The contribution of seven known and nine predicted genes or operons associated with multidrug resistance to the susceptibility of Escherichia coli W3110 was assessed for 20 different classes of antimicrobial compounds that include antibiotics, antiseptics, detergents, and dyes. Strains were constructed with deletions for genes in the major facilitator superfamily, the resistance nodulation-cell division family, the small multidrug resistance family, the ATP-binding cassette family, and outer membrane factors. The agar dilution MICs of 35 compounds were determined for strains with deletions for multidrug resistance (MDR) pumps. Deletions in acrAB or tolC resulted in increased susceptibilities to the majority of compounds tested. The remaining MDR pump gene deletions resulted in increased susceptibilities to far fewer compounds. The results identify which MDR pumps contribute to intrinsic resistance under the conditions tested and supply practical information useful for designing sensitive assay strains for cell-based screening of antibacterial compounds.
Chiral separation of heterocyclic drugs by HPLC: solute-stationary phase base-pair interactions (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChiral separation of heterocyclic drugs by HPLC: solute-stationary phase base-pair interactionsBinyamin. Feibush, Alvaro. Figueroa, Rosita. Charles, Kay D. Onan, Pnina. Feibush, and Barry L. KargerCite this: J. Am. Chem. Soc. 1986, 108, 12, 3310–3318Publication Date (Print):June 1, 1986Publication History Published online1 May 2002Published inissue 1 June 1986https://pubs.acs.org/doi/10.1021/ja00272a027https://doi.org/10.1021/ja00272a027research-articleACS PublicationsRequest reuse permissionsArticle Views916Altmetric-Citations112LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
<title>Multiple-description image coding with distributed source coding and side information</title> (2004)

Multiple description coding (MDC) is a source coding technique that involves coding the source information into multiple descriptions. When these descriptions are transmitted over different channels in packet network or error-prone wireless environment, graceful degradation can be achieved even if part of descriptions are not received by the receiver. When MDC is applied to wavelet subband based image coding, it is possible to introduce correlation between the descriptions in each subband. In this paper, we consider using such a correlation as well as potentially error corrupted description as side information in the decoding to formulate the MDC decoding as a Wyner Ziv decoding problem. If only part of descriptions is lost, however, their correlation information is still available. Therefore, the proposed Wyner Ziv decoder can recover the description by using the correlation information and the error corrupted description as side information. High quality reconstruction can still be obtained by combining the decoded descriptions from Wyner Ziv decoder. The proposed scheme takes advantage of an efficient way to use the correlation information, thus makes the system more robust to channel error corruption. Experimental result shows that, comparing to conventional multiple description wavelet based image coding, the PSNR of the received and decoded image could be improved noticeably when coding at the same bit rate.
GESIA: uncertainty-based reasoning for a generic expert system intelligent user interface (2005)

Generic expert systems are reasoning systems that can be used in many application domains, thus requiring domain independence. The user interface for a generic expert system must contain intelligence in order to maintain this domain independence and manage the complex interactions between the user and the expert system. This paper explores the uncertainty-based reasoning contained in an intelligent user interface called GESIA. GESIA's interface architecture and dynamically constructed Bayesian network are examined in detail to show how uncertainty-based reasoning enhances the capabilities of this user interface.
Oxidative Stress in Lungs of Mice Infected with Influenza a Virus (1992)

As oxidative stress has been implicated in the pathogenesis of certain viral diseases we determined antioxidant and prooxidant parameters in lungs and bronchoalveolar lavage fluid (BALF) of mice infected with a lethal dose of influenza A/PR8/34 virus. Viral infection was characterized by massive infiltration of leukocytes, mainly polymorphonuclear leukocytes, into the alveolar space. The total number of BALF cells increased up to 8-fold (day 3 post-infection) and these cells appeared activated as judged by their increased rates of superoxide anion radical (O2-.) generation upon stimulation. Maximal rates of radical generation by BALF cells during the early stages of infection were 15- or 70-fold higher than those of cells from control animals when expressed per cell or total BALF cells, respectively. At the terminal stages of infection the total capacity of BALF cells to release O2-. declined to approximately 35-fold the control values. Infection also resulted in increased in vivo formation of hydrogen peroxide (H2O2) within the lungs at a time that coincided with the maximal capacity of BALF cells to release O2-.. Whereas pulmonary activities of glutathione peroxidase and reductase remained unaltered, levels of ascorbate in the cell-free BALF decreased significantly during the early stages of the infection and then returned to normal levels and above, late in infection. The oxidation state of the dehydroascorbic acid/ascorbate couple increased concomitantly with the decrease in ascorbate concentrations early in infection and remained elevated throughout the infection. As assessed by the prevention of peroxyl radical-induced loss of phycoerythrin fluorescence, the total antioxidant capacity present in lung tissue homogenate from terminally ill animals was not diminished when compared to that prepared from lungs of control mice. We conclude that although early stages of influenza infection are associated with the presence of oxidative stress in the lung tissue and alveolar fluid lining the epithelial cells, this stress does not appear to overwhelm local antioxidant defenses. The results therefore do not support a direct causative role of oxidative tissue damage in the pathogenesis of influenza virus infection.
Improved statistical machine translation using monolingually-derived paraphrases (2009)

Untranslated words still constitute a major problem for Statistical Machine Translation (SMT), and current SMT systems are limited by the quantity of parallel training texts. Augmenting the training data with paraphrases generated by pivoting through other languages alleviates this problem, especially for the so-called "low density" languages. But pivoting requires additional parallel texts. We address this problem by deriving paraphrases monolingually, using distributional semantic similarity measures, thus providing access to larger training resources, such as comparable and unrelated monolingual corpora. We present what is to our knowledge the first successful integration of a collocational approach to untranslated words with an end-to-end, state of the art SMT system demonstrating significant translation improvements in a low-resource setting.