gebhart/patrepeval huggingface dataset:
Angiotensin 1–7 mediates renoprotection against diabetic nephropathy by reducing oxidative stress, inflammation, and lipotoxicity (2014)

The renin-angiotensin system, especially angiotensin II (ANG II), plays a key role in the development and progression of diabetic nephropathy. ANG 1-7 has counteracting effects on ANG II and is known to exert beneficial effects on diabetic nephropathy. We studied the mechanism of ANG 1-7-induced beneficial effects on diabetic nephropathy in db/db mice. We administered ANG 1-7 (0.5 mg·kg(-1)·day(-1)) or saline to 5-mo-old db/db mice for 28 days via implanted micro-osmotic pumps. ANG 1-7 treatment reduced kidney weight and ameliorated mesangial expansion and increased urinary albumin excretion, characteristic features of diabetic nephropathy, in db/db mice. ANG 1-7 decreased renal fibrosis in db/db mice, which correlated with dephosphorylation of the signal transducer and activator of transcription 3 (STAT3) pathway. ANG 1-7 treatment also suppressed the production of reactive oxygen species via attenuation of NADPH oxidase activity and reduced inflammation in perirenal adipose tissue. Furthermore, ANG 1-7 treatment decreased lipid accumulation in db/db kidneys, accompanied by increased expressions of renal adipose triglyceride lipase (ATGL). Alterations in ATGL expression correlated with increased SIRT1 expression and deacetylation of FOXO1. The upregulation of angiotensin-converting enzyme 2 levels in diabetic nephropathy was normalized by ANG 1-7. ANG 1-7 treatment exerts renoprotective effects on diabetic nephropathy, associated with reduction of oxidative stress, inflammation, fibrosis, and lipotoxicity. ANG 1-7 can represent a promising therapy for diabetic nephropathy.
Dean's handbook of organic chemistry (2004)

PrefaceChapter 1: Organic CompoundsChapter 2: Inorganic and Organometallic CompoundsChapter 3: Properties of Atoms, Radicals, and BondsChapter 4: Physical PropertiesChapter 5: Thermodynamic PropertiesChapter 6: SpectroscopyChapter 7: Physiochemical RelationshipsChapter 8: Electrolytes, Electromotive Force, and Chemical EquilibriumChapter 9: Data Useful in Laboratory Manipulations and AnalysisChapter 10: Polymers, Rubbers, Fats, Oils, and WaxesChapter 11: Abbreviations, Constants, and Conversion FactorsINDEX
Mathematical Methods in Image Reconstruction (2001)

1. Introduction 2. Integral geometry 3. Tomography 4. Stability and resolution 5. Reconstruction algorithms 6. Problems that have peculiarities 7. Nonlinear tomography.
Treatment of IgA nephropathy with eicosapentanoic acid (EPA): a two-year prospective trial. (1989)

Thirty-seven patients with biopsy proven mesangial IgA nephropathy were prospectively allocated to either two years of treatment with eicosapentanoic acid (EPA) 10 g per day or no treatment. At entry treated and untreated patients with renal dysfunction (Group A) or patients with normal serum creatinine less than 0.12 mmol/l (Group B) did not differ in serum creatinine, creatinine clearance, urinary protein excretion, or quantitative urinary red cell counts. Compliance with EPA therapy was excellent as assessed by plasma fatty acid profiles. At the end of the trial creatinine clearance in treated patients had gone from 80 +/- 16 to 57 +/- 17 ml/min (p less than 0.05) and in untreated patients from 76 +/- 18 to 55 +/- 14 (p less than 0.05). There were no beneficial effects in either Group A or Group B patients. The only two patients who had improvement in renal function were in the EPA treatment group. Although no side effects of treatment were noted, EPA does not alter the course of established mesangial IgA nephropathy.
Nonperfused Attachment Systems for Cell Cultivation (2018)

The pressing need for large-scale culture methods has prompted efforts to develop vessels which will accommodate the growth of large numbers of anchorage-dependent cells. The large-scale "cell factories" have been used to grow viruses for vaccine production, nucleic acid studies, and various cancer research projects. Two particular types of culture vessels used for large-scale production of anchorage-dependent cells were discussed and examples of their use in vaccine production given. Development of these large-scale culture systems has enabled the pharmaceutical companies to (1) meet the ever-increasing demands worldwide for vaccine, (2) employ a production process that produces a cost-efficient vaccine product in cell culture, and (3) produce large volumes of bulk vaccine at a single campaign, thus allowing multiple usage of a single production unit over the course of a year. The type of large-scale culture vessel used depends on the purpose of the culture and the type of cells that are to be grown in the vessel. The unit process vessel, with its multidisks, provides superior surface area, but because of the stainless steel housing, the cells cannot be monitored microscopically. Additionally, the unit process vessel can be equipped with a jacket for precise temperature regulation and thus eliminate the need for incubators. The roller bottles, on the other hand, allow microscopic monitoring of the growing cells but are limited in surface area available for growth, and the volume of harvest fluid obtainable from a bottle is very limited. It should be noted that handling of roller bottles is labor-intensive and requires many more manipulations and hence more personnel than employing unit process-type vessels for vaccine-manufacturing operations. The use of mass cultivation techniques in cancer research has also been of immense benefit. The production of large numbers of neoplastic cells has provided researchers with the raw materials to perform molecular biology experiments such as DNA sequencing, which required milligram quantities of cells before sufficient quantities of DNA could be isolated to allow sequencing studies. Additionally, the technique of mass cultivation also provided sufficient quantities of cells for inoculation into either nude mice or immunosuppressed hamsters in an attempt to determine the tumor induction capacity of the cultured cells. Additional characterization studies which require large numbers of cell, enzyme, and isoenzyme profiles can also be performed on cells grown in roller bottle cultures. There are numerous factors which limit the productivity of mass cultivation systems and the scientist should be aware of their existence.(ABSTRACT TRUNCATED AT 400 WORDS)
Phosphatidylserine synthesis in Saccharomyces cerevisiae. Purification and characterization of membrane-associated phosphatidylserine synthase. (1984)

Membrane-associated phosphatidylserine synthase (CDP-diacylglycerol:L-serine O-phosphatidyltransferase, EC 2.7.8.8) was purified from the microsomal fraction of Saccharomyces cerevisiae strains S288C and VAL2C(YEpCHO1). VAL2C(YEpCHO1) contains a hybrid plasmid bearing the structural gene for phosphatidylserine synthase and overproduces the enzyme 6-7 fold (Letts, V. A., Klig, L. S., Bae-Lee, M., Carman, G. M., and Henry, S. A. (1983) Proc. Natl. Acad. Sci. U. S. A. 80, 7279-7283) compared to wild-type S288C. The purification procedure included Triton X-100 extraction of the microsomal membranes, CDP-diacylglycerol-Sepharose affinity chromatography, and DE-53 chromatography. The procedure yielded a preparation from each strain containing a major peptide band (Mr = 23,000) upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Phosphatidylserine synthase was dependent on manganese and Triton X-100 for maximum activity at pH 8.0. The apparent Km values for serine and CDP-diacylglycerol were 0.58 mM and 60 microM, respectively. Thioreactive agents inhibited enzyme activity. The enzyme was thermally labile above 40 degrees C. Results of isotopic exchange reactions between substrates and products suggest that the enzyme catalyzes a sequential Bi Bi reaction.
The Influences of Race, Ethnicity, and Poverty on the Mental Health of Children (2000)

Sufficient evidence demonstrates that poverty has a negative effect on the psychological well-being of children, but most research has focused only on white populations. The purpose of this literature review is to gain a better understanding of the positive and negative influences of socioeconomic factors, cultural/ethnic characteristics, and racial differences on the mental health of children. A review of the literature on the influence of race, ethnicity, and poverty on the mental health of children found that (1) children whose parents are in poverty or who have experienced severe economic losses are more likely to report or be reported to have higher rates of depression, anxiety, and antisocial behaviors; and (2) after controlling for socioeconomic status, African Americans, Native Americans, and Hispanics are less likely to report or be reported to have such mental health problems. A theoretical construct for this protective effect is related to cultural factors, such as perceived social support, deep religiosity/spirituality, extended families, and maternal coping strategies as buffers against psychological distress.
Carbohydrate Metabolism in Zymomonas (1988)

Cet article de synthese aborde successivement le metabolisme anaerobie du glucose, du fructose, du saccharose puis le metabolisme des glucides en aerobiose. Le probleme de la production de sous produits indesirables (levane, sorbitol, glycerol, acetoine, ...) accompagnant la production d'ethanol par fermentation du fructose et du saccharose par Zymomonas mobilis est plus particulierement evoque
Ectopic expression of CCL19 impairs alloimmune response in mice (2004)

Initiation of an antitumour immune response is characterized by a complex process of chemokine-mediated cell migration and cell-cell interactions. Overexpression of chemokine CCL19 in tumour cells has been shown to result in accelerated tumour rejection under certain experimental conditions, suggesting a novel approach in the therapy of neoplastic malignancies. To investigate CCL19-mediated modulations of cellular immune responses in vivo, we generated a chimeric CCL19-immunoglobulin G2b (IgG2b) Fc fusion protein, which binds to the chemokine receptor CCR7 comparable to native CCL19. CCL19-IgG2b possesses a long-lasting potent chemotactic activity as a result of the extended half-life of Fc fusion proteins. Stable overexpression of CCL19-IgG2b in BALB/c-derived J558L tumour cells fails to support tumour cell rejection following transplantation in syngeneic mice. Moreover, overexpression of CCL19-IgG2b hinders tumour rejection in allogeneic C57BL/6 mice. This phenomenon was accompanied by a six-fold increase of dendritic cells (DCs) isolated from CCL19-IgG2b-secreting tumours when compared to the number of DCs isolated from control parental J558L tumours. While mice bearing the allogeneic parental tumour showed an intense hypercellularity in the draining lymph nodes, no such response could be observed in the draining lymph nodes of mice carrying the CCL19-IgG2b-secreting tumour. We could demonstrate that overexpression of CCL19-IgG2b in tumour cells retains antigen-presenting cells in the tumour mass and prevents DCs from migrating into draining lymph nodes to present antigens and to activate T cells, resulting in an impaired immune response against the tumour.
Fast imaging of shallow resistivity structures using a multichannel capacitive electrode system (1995)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1995Fast imaging of shallow resistivity structures using a multichannel capacitive electrode systemAuthors: Hiromasa ShimaBenoit TexierTsuyoshi KobayashiNobusuke HasegawaHiromasa ShimaOYO Corporation, Japan, Benoit TexierIRIS Instruments, France;, Tsuyoshi KobayashiOYO Corporation, Japan, and Nobusuke HasegawaOYO Corporation, Japanhttps://doi.org/10.1190/1.1887448 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1887448FiguresReferencesRelatedDetailsCited ByFundamentals of the capacitive resistivity techniqueOliver Kuras, David Beamish, Philip I. Meldrum, and Richard D. Ogilvy26 May 2006 | GEOPHYSICS, Vol. 71, No. 3 SEG Technical Program Expanded Abstracts 1995ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1995 Pages: 1566 publication data© 1995 Copyright © 1995 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Hiromasa Shima, Benoit Texier, Tsuyoshi Kobayashi, and Nobusuke Hasegawa, (1995), "Fast imaging of shallow resistivity structures using a multichannel capacitive electrode system," SEG Technical Program Expanded Abstracts : 377-380. https://doi.org/10.1190/1.1887448 Plain-Language Summary PDF DownloadLoading ...
Electronic Aptamer‐Based Sensors (2007)

The selection of aptamers-nucleic acids that specifically bind low-molecular-weight substrates or proteins-by the SELEX (systematic evolution of ligands by exponential enrichment) procedure has attracted recent efforts directed to the development of new specific recognition units. In particular, extensive activities have been directed to the application of aptamers as versatile materials for the design of biosensors. The Minireview summarizes the recent accomplishments in developing electronic aptamer-based sensors (aptasensors), which include electrochemical, field-effect transistor, and microgravimetric quartz crystal microbalance sensors, and describes methods to develop amplified aptasensor devices and label-free aptasensors.
The Role of Neoadjuvant Therapy in Pancreatic Cancer: A Review (2016)

Controversy remains regarding neoadjuvant approaches in the treatment of pancreatic cancer. Neoadjuvant therapy has several potential advantages over adjuvant therapy including earlier delivery of systemic treatment, in vivo assessment of response, increased resectability rate in borderline resectable patients and increased margin-negative resection rate. At present, there are no randomized data favoring neoadjuvant over adjuvant therapy and multiple neoadjuvant approaches are under investigation. Combination chemotherapy regimens including 5-fluorouracil, irinotecan and oxaliplatin, gemcitabine with or without abraxane, or docetaxel and capecitabine have been used in the neoadjuvant setting. Radiation and chemoradiation have also been incorporated into neoadjuvant strategies, and delivery of alternative fractionation regimens is being explored. This review provides an overview of neoadjuvant therapies for pancreatic cancer.
Improvement of Repolarization Abnormalities by a K + Channel Opener in the LQT1 Form of Congenital Long-QT Syndrome (1998)

Our results suggest that nicorandil, a K+ channel opener, improves repolarization abnormalities in the LQT1 form of congenital long-QT syndrome with KvLQT1 defect.
A cost-analysis of complex workplace nutrition education and environmental dietary modification interventions (2017)

Current Controlled Trials: ISRCTN35108237 . Date of registration: The trial was retrospectively registered on 02/07/2013.
Co-integrated Dual Strained Channels on Fully Depleted sSDOI CMOSFETs with HfO&amp;gt;inf&amp;lt;2&amp;gt;/inf&amp;lt;/TiN Gate Stack down to 15nm Gate Length (2006)

We report an original dual channel fully depleted CMOSFET architecture on insulator (DCOI) co-integrating strained-Si (nMOS) and strained-Si/sub 0.6/Ge/sub 0.4/ (pMOS) with HfO/sub 2//TiN gate stacks down to 15nm gate length. We demonstrate for the first time an I/sub ON/ improvement for short channel SOI of 10% at 35nm gate length (25% at 75nm, 100% on long channels) for both n- and p-MOSFETs and a more than 3 decades gate leakage reduction compared to a SiO/sub 2/ dielectric. Meanwhile, thanks to the dual channel engineering, a threshold voltage adjustment is performed with a mid gap single metal gate suitable for high performance (HP) CMOS.
Floodplain Management Planning: The Wellington Regional Council Approach (1995)

Legislative and public attitude changes over the last decade have necessitated a re-think of the way in which flood mitigation measures are delivered to the community. There is afar greater emphasis on a consultative approach to the selection of flood hazard strategies. The Wellington Regional Council have accepted this and significantly modified it's approach to the floodplain management planning process to include public involvement in the widest sense. This has influenced both the content of the plans and the way in which they are developed and implemented. The following paper outlines the approach adopted by the Wellington Regional Council and identifies some of the issues that have arisen as a result of this consultative approach using the experiences gained from the preparation of the Waikanae River Floodplain Management Plan.
Human tonsil B - cell lymphoma 6 ( BCL6 )-expressing CD4 + T-cell subset specialized for B-cell help outside germinal centers (2011)

T follicular helper (Tfh) cells represent a Th subset engaged in the help of B-cell responses in germinal centers (GCs). Tfh cells abundantly express the transcription repressor B-cell lymphoma 6 (Bcl6), a factor that is necessary and sufficient for their development in vivo. Whether Tfh or Tfh-committed cells are involved in the help of B cells outside GCs remains unclear, particularly in humans. In this study, we identified a previously undefined BCL6-expressing CD4(+) T-cell subset in human tonsils. This subset expressed IL-7 receptor and chemokine receptor 5 (CXCR5) and inducible costimulator (ICOS) at low levels (CXCR5(lo)ICOS(lo)), and it was found exclusively outside GCs. CXCR5(lo)ICOS(lo) CD4(+) T cells secreted larger amounts of IL-21 and IL-10 than CXCR5(hi)ICOS(hi) GC-Tfh cells upon activation, and they induced proliferation and differentiation of naïve B cells into Ig-producing cells more efficiently than GC-Tfh cells. However, this subset lacked the capacity to help GC-B cells because of the induction of apoptosis of GC-B cells through the FAS/FAS-ligand interaction. CXCR5(lo)ICOS(lo) CD4(+) T cells expressed equivalent amounts of BCL6 transcript with CXCR5(hi)ICOS(hi) GC-Tfh cells, but they expressed less Bcl6 protein. Collectively, our study indicates that CXCR5(lo)ICOS(lo) CD4(+) T cells in human tonsils represent Tfh lineage-committed cells that provide help to naïve and memory B cells outside GCs.
A probabilistic framework for space carving (2002)

This paper introduces a new probabilistic framework for Space Carving. In this framework each voxel is assigned a probability, which is computed by comparing the likelihoods for the voxel existing and not existing. This new framework avoids many of the difficulties associated with the original Space Carving algorithm. Specifically, it does not need a global threshold parameter, and it guarantees that no holes will be carved in the model. This paper also proposes that a voxel-based thick texture is a realistic and efficient representation for scenes which contain dominant planes. The algorithm is tested using both real and synthetic data, and both qualitative and quantitative results are presented.
Metolachlor Efficacy as Influenced by Three Acetolactate Synthase-Inhibiting Herbicides (1998)

In preliminary field trials, a reduction in grass control was observed when flumetsulam or MON 12037 with and without the safener MON 13900 was applied with metolachlor compared to metolachlor alone. Greenhouse studies were initiated to study potential interactions between acetolactate synthase (ALS)-inhibiting herbicides and metolachlor. Metolachlor at 0.14, 0.28, and 0.56 kg ai/ha was applied alone and in combination with flumetsulam at 0.0073 and 0.015 kg ai/ha and MON 12037 with safener at 0.011 and 0.021 kg ai/ha. Flumetsulam and MON 12037 with safener alone provided 13 to 23% visible barnyardgrass control and metolachlor at 0.14 kg/ha provided 82% control. Combining flumetsulam and MON 12037 with metolachlor did not increase herbicide activity beyond that observed from metolachlor alone, regardless of the parameter evaluated. Combinations of 0.14 kg/ha of metolachlor with 0.011 and 0.021 kg/ha of MON 12037 with safener or 0.015 kg/ha of flumetsulam resulted in antagonism of barnyardgrass according to Colby's multiplicative interactive model. Visible control and plant dry weight were also antagonized when 0.28 kg/ha of metolachlor was applied with 0.021 kg/ha of MON 12037 with safener. Field studies were conducted in corn and soybean to evaluate giant foxtail control from metolachlor alone and in tank mixtures with flumetsulam, chlorimuron and MON 12037 with and without safener. Although isolated incidences of antagonism were noted, there was no consistent effect on grass control when these ALS-inhibiting herbicides were applied in combination with metolachlor in 3 years of field trials.
Tau inhibits anterograde axonal transport and perturbs stability in growing axonal neurites in part by displacing kinesin cargo: Neurofilaments attenuate tau‐mediated neurite instability (2007)

Overexpression of tau compromises axonal transport and induces retraction of growing neurites. We tested the hypothesis that increased stability provided by neurofilaments (NFs) may prevent axonal retraction. NB2a/d1 cells were differentiated for 3 days, at which time phosphorylated NFs appear and for 14 days, which induces continued neurite elongation and further phospho-NF accumulation. Cultures were transfected with a construct that expresses full-length, 4-repeat tau. Consistent with prior studies, overexpression of tau induced retraction of day three axonal neurites even following treatment with the microtubule-stabilizing drug taxol. Axonal neurites of day 14 cells were more resistant to tau-mediated retraction. To test whether or not this resistance was derived from their additional NF content, day 3 cultures were co-transfected with constructs expressing tau and NF-M (which increases overall axonal NFs). Overexpression of NF-M attenuated tau-mediated retraction of day 3 axonal neurites. By contrast, co-transfection with constructs expressing tau and vimentin (which increases axonal neurites length) did not attenuate tau-mediated neurite retraction. Co-precipitation experiments indicate that tau is a cargo of kinesin, and that tau overexpression may displace other kinesin-based cargo, including both critical cytoskeletal proteins and organelles. However, cultures simultaneously transfected with constructs expressing NF-M and tau, the level of examined vesicles was maintained. These collectively indicate that NFs stabilize developing axonal neurites and can counteract the destabilizing force resulting from overexpression of tau, and underscore that the development and stabilization of axonal neurites is dependent upon a balance of cytoskeletal elements.
CD26 Antigen is a Surface Dipeptidyl Peptidase IV (DPPIV) as Characterized by Monoclonal Antibodies Clone Til‐19‐4‐7 and 4EL1C7 (1990)

In this study we investigated the binding of three different monoclonal antibodies (MoAb), TII 19-4-7, 4EL1C7, and B1.19.2, which are clustered in CD26 to the ectoenzyme dipeptidyl peptidase IV (DPP IV) and to T lymphocytes. We found that all three MoAb bind to both unstimulated and mitogen-stimulated T lymphocytes. Further results indicated an inconsistency within the CD26-clustered MoAb: TII 19-4-7 and 4EL1C7, but not B1.19.2, recognized DPP IV on the surface o T lymphocytes and immobilized on solid-phase ELISA or Western blot. There was competition of binding to DPP IV between TII 19-4-7 and 4EL1C7. From these results we conclude that CD26 antigen is represented by the ectoenzyme DPP IV. TII 19-4-7 and 4EL1C7 recognize the same or partly identical epitopes on DPP IV, whereas B1.19.2 recognizes a different antigen. TII 19-4-7 and 4EL1C7, but not B1.19.2, should be clustered in CD26.