gebhart/patrepeval huggingface dataset:
Synthesis and characterization of mesoporous silica core-shell particles (2010)

Core-shell particles were formed by deposition of primary silica particles synthesized from sodium silicate solution on functionalized silica core particles (having size of ~0.5 ?m) prepared by hydrolysis and condensation of tetraethylortosilicate. The obtained mesoporous shell has thickness of about 60 nm and consists of primary silica particles with average size of ~21 nm. Scanning electron microscopy and zeta potential measurements showed that continuous silica shell exists around functionalized core particles which was additionally proved by FTIR and TEM results.
A study of a target tracking algorithm using global nearest neighbor approach (2003)

This paper compares two algorithms for Multiple Target Tracking (MTT), using Global Nearest Neighbor (GNN) and Suboptimal Nearest Neighbor (SNN) approach respectively. For both algorithms the observations are divided in clusters to reduce computational efforts. For each cluster the assignment problem is solved by using Munkres algorithm or according SNN rules. Results reveal that in some cases the GNN approach gives batter solution than.SNN approach. The computational time, needed for assignment problem solution using Munkres algorithm is studied and results prove that it is suitable for real time implementations.
Control over a phase state of the laser plume ablated by femtosecond laser: Spatial pulse shaping (2004)

The conditions for the formation of a fully atomized laser-ablated plume using subpicosecond laser pulses have been studied theoretically and implemented experimentally. It is shown that the low-intensity wings, which generally exist in the spatial distribution of laser intensity in the focal plane and can contain a substantial part of the incident laser energy, are responsible for low-threshold phase transformations of the target and this is the major source of particulates in the ablated plume. By truncating these wings with a simple aperture and positioning the target in the image plane of that aperture, particulates can be eliminated from the plume. This is demonstrated in experiments on deposition of Si films using the truncated beam in combination with the proper choice of laser fluence. This results in an almost totally atomized plume and consequently in droplet-free deposition of thin films.
Raman spectroscopy: elucidation of biochemical changes in carcinogenesis of oesophagus (2006)

Several techniques are under development to diagnose oesophageal adenocarcinoma at an earlier stage. We have demonstrated the potential of Raman spectroscopy, an optical diagnostic technique, for the identification and classification of malignant changes. However, there is no clear recognition of the biochemical changes that distinguish between the different stages of disease. Our aim is to understand these changes through Raman mapping studies. Raman spectral mapping was used to analyse 20-microm sections of tissue from 29 snap-frozen oesophageal biopsies. Contiguous haematoxylin and eosin sections were reviewed by a consultant pathologist. Principal component analysis was used to identify the major differences between the spectra across each map. Pseudocolour score maps were generated and the peaks of corresponding loads identified enabling visualisation of the biochemical changes associated with malignancy. Changes were noted in the distribution of DNA, glycogen, lipids and proteins. The mean spectra obtained from selected regions demonstrate increased levels of glycogen in the squamous area compared with increased DNA levels in the abnormal region. Raman spectroscopy is a highly sensitive and specific technique for demonstration of biochemical changes in the carcinogenesis of Barrett's oesophagus. There is potential for in vivo application for real-time endoscopic optical diagnosis.
A METHOD FOR DYNAMIC CHARACTERISTICS ESTIMATION OF SUBSURFACE USING MICROTREMOR ON THE GROUND SURFACE (1989)

As methods for dynamic characteristics estimation of surface layers, investigation with boring and a method which employs microtremor are well known so far. Boring investigation, one of the most accurate methods is costly and time consuming and is not available all the time. The method that employs microtremor is handy but has not produced satisfactory result to this day. This paper describes a new processing method that employs microtremor observation yet producing accurate estimation of characteristics of the ground motion. The method uses vertical component and horizontal components. As a result, the spectrum ratio of the horizontal components and vertical component of microtremor bears resemblance to transfer function for horizontal motion of surface layers.
Flow cytometry (1980)

A brief review of flow cytometry is presented. Emphasis is on the construction of relatively simple instruments and on their application to problems in medical physics. Among these are the problems of measuring the biological parameters that determine the response of tumors to therapy and of measuring the biological damage in people exposed to ionizing radiations.
SilkRoad (2017)

In this paper, we show that up to hundreds of software load balancer (SLB) servers can be replaced by a single modern switching ASIC, potentially reducing the cost of load balancing by over two orders of magnitude. Today, large data centers typically employ hundreds or thousands of servers to load-balance incoming traffic over application servers. These software load balancers (SLBs) map packets destined to a service (with a virtual IP address, or VIP), to a pool of servers tasked with providing the service (with multiple direct IP addresses, or DIPs). An SLB is stateful, it must always map a connection to the same server, even if the pool of servers changes and/or if the load is spread differently across the pool. This property is called per-connection consistency or PCC. The challenge is that the load balancer must keep track of millions of connections simultaneously.
A survey and classification of hypertext documentation systems (1992)

The authors describe and classify different hypertext documentation approaches by surveying a number of existing systems. They comprehensively list features of each system but do not numerically compare systems because of the subjective nature of evaluation. Instead, the data provided should be used as a basis for local comparisons by the reader. The classification breaks systems down according to publishing type, i.e. those designed for both publishing and accessing hypertext, either publishing or accessing documentation, and those that use general-purpose hypertext systems for document production and presentation. These categories are further subdivided according to functionality and specific system information.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Evaluation of a bovine viral diarrhea vaccine produced in a porcine kidney cell line. (1975)

An attenuated bovine viral diarrhea (BVD) live-virus vaccine, produced in a continuous porcine cell line, evoked an immune response which produced a protective level of serum antibodies in vaccinated cattle. Post-vaccinal reactions to the vaccinal virus were not observed in cattle vaccinated at 5 feedlots or in cattle vaccinated in experimental tests. The vaccinal virus did not produce demonstrable viremia or detectable excretion of virus from the respiratory or digestive tracts. Leukopenia or abnormality in differential leukocyte values did not occur as with virulent BVD viral infection. Transmission of vaccinal virus from vaccinated cattle to susceptible controls did not occur under conditions in which vaccinated and nonvaccinated cattle were in constant contact for 28 days.
How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain? (2005)

Transcranial direct current stimulation (tDCS) of the primary motor hand area (M1) can produce lasting polarity-specific effects on corticospinal excitability and motor learning in humans. In 16 healthy volunteers, O positron emission tomography (PET) of regional cerebral blood flow (rCBF) at rest and during finger movements was used to map lasting changes in regional synaptic activity following 10 min of tDCS (+/-1 mA). Bipolar tDCS was given through electrodes placed over the left M1 and right frontopolar cortex. Eight subjects received anodal or cathodal tDCS of the left M1, respectively. When compared to sham tDCS, anodal and cathodal tDCS induced widespread increases and decreases in rCBF in cortical and subcortical areas. These changes in rCBF were of the same magnitude as task-related rCBF changes during finger movements and remained stable throughout the 50-min period of PET scanning. Relative increases in rCBF after real tDCS compared to sham tDCS were found in the left M1, right frontal pole, right primary sensorimotor cortex and posterior brain regions irrespective of polarity. With the exception of some posterior and ventral areas, anodal tDCS increased rCBF in many cortical and subcortical regions compared to cathodal tDCS. Only the left dorsal premotor cortex demonstrated an increase in movement related activity after cathodal tDCS, however, modest compared with the relatively strong movement-independent effects of tDCS. Otherwise, movement related activity was unaffected by tDCS. Our results indicate that tDCS is an effective means of provoking sustained and widespread changes in regional neuronal activity. The extensive spatial and temporal effects of tDCS need to be taken into account when tDCS is used to modify brain function.
Autonomous decentralized manufacturing system using high-speed network with inductive transmission of data and power (2002)

This paper introduces an idea of an autonomous decentralized manufacturing system (ADMS), which has the capability of adaptive reconfiguration to the product variations. In ADMS, machines are decentrally controlled by way of common high speed data networks, and the degree of mechanical motion freedom is increased with the use of inductive power and data transmission. The technology subsets required for realizing the field network and inductive couplings are described in this paper. The ADMS is conceptually realized for the automobile production line using the prototypes of the proposed technology subsets.
Development of a BIONic Muscle Spindle for Prosthetic Proprioception (2007)

The replacement of proprioceptive function, whether for conscious sensation or feedback control, is likely to be an important aspect of neural prosthetic restoration of limb movements. Thus far, however, it has been hampered by the absence of unobtrusive sensors. We propose a method whereby fully implanted, telemetrically operated BIONs monitor muscle movement, and thereby detect changes in joint angle(s) and/or limb posture without requiring the use of secondary components attached to limb segments or external reference frames. The sensor system is designed to detect variations in the electrical coupling between devices implanted in neighboring muscles that result from changes in their relative position as the muscles contract and stretch with joint motion. The goal of this study was to develop and empirically validate mathematical models of the sensing scheme and to use computer simulations to provide an early proof of concept and inform design of the overall sensor system. Results from experiments using paired dipoles in a saline bath and finite element simulations have given insight into the current distribution and potential gradients exhibited within bounded anisotropic environments similar to a human limb segment and demonstrated an anticipated signal to noise ratio of at least 8:1 for submillimeter resolution of relative implant movement over a range of implant displacements up to 15 cm.
Alterations in Blood-Brain Barrier Permeability to Large and Small Molecules and Leukocyte Accumulation after Traumatic Brain Injury: Effects of Post-Traumatic Hypothermia (2009)

We investigated the temporal and regional profile of blood-brain barrier (BBB) permeability to both large and small molecules after moderate fluid percussion (FP) brain injury in rats and determined the effects of post-traumatic modest hypothermia (33 degrees C/4 h) on these vascular perturbations. The visible tracers biotin-dextrin-amine 3000 (BDA-3K, 3 kDa) and horseradish peroxidase (HRP, 44 kDa) were injected intravenously at 4 h or 3 or 7 days post-TBI. At 30 min after the tracer infusion, both small and large molecular weight tracers were detected in the contusion area as well as remote regions adjacent to the injury epicenter in both cortical and hippocampal structures. In areas adjacent to the contusion site, increased permeability to the small molecular weight tracer (BDA-3K) was evident at 4 h post-TBI and remained visible after 7 days survival. In contrast, the larger tracer molecule (HRP) appeared in these remote areas at acute permeable sites but was not detected at later post-traumatic time periods. A regionally specific relationship was documented at 3 days between the late-occurring permeability changes observed with BDA-3K and the accumulation of CD68-positive macrophages. Mild hypothermia initiated 30 min after TBI reduced permeability to both large and small tracers and the infiltration of CD68-positive cells. These results indicate that moderate brain injury produces temperature-sensitive acute, as well as more long-lasting vascular perturbations associated with secondary injury mechanisms.
Can the TAG derivation tree represent a semantic graph? An answer in the light of Meaning-Text Theory (1998)

Introduction From the parsing point of view, the derivation tree in TAG [hereafter DT] is seen as the &amp;quot;history&amp;quot; of the derivation but also as a linguistic representation, closer to semantics, that can be the basis of a further analysis. Because in TAG the elementary trees are lexicalized and localize the predicate-arguments relations, several works have compared the DT to a structure involving dependencies between lexical items (RJ92; RVW95). 1 We agree with these authors that there are divergences between the DT and syntactic dependencies, but we show here that the DT --- in the sense of (SS94) --- can be viewed as a semantic dependency graph, namely a SemS for Meaning-Text Theory [MTT] (ZM67; M88). This requires the predicate-argument cooccurrence principle and also constraints on the adjunction of predicative auxiliary trees. We briefly introduce the representation levels in MTT before studying the dependencies shown by the DT. 2 1. Repre
Estimation of 3D angular motion using gyroscopes and linear accelerometers (1991)

The authors present a novel, real-time angular motion estimation technique using a linear Gaussian estimator, and the outputs of linear accelerometers and gyroscopes, to assess the actual angular velocity of a rigid body in three-dimensional (3D) space. The method obtains the covariances of the random actual 3D angular velocity, the angular velocity measurement, and the measurement noise from the time averages of the outputs of an array of nine linear accelerometers and the outputs of three orthogonal gyroscopes. These statistics are used by the estimator to calculate the angular velocity of the rigid body in 3D space. The multisensor technique performance is evaluated through a computer simulation. Results indicate that the method leads to more accurate angular velocity values than are obtained conventionally.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Pirfenidone Slows Renal Function Decline in Patients with Focal Segmental Glomerulosclerosis (2007)

It is concluded that pirfenidone is an attractive candidate for placebo-controlled trials in patients with progressive chronic kidney disease.
Haemophilus influenzae and Neisseria gonorrhoeae Recognize Different Specificity Determinants in the DNA Uptake Step of Genetic Transformation (1982)

Cross-transformation and quantitative competition experiments showed that Neisseria gonorrhoeae and Haemophilus influenzae do not interact with each other's DNA in transformation. These organisms must interact with different recognition sequences during DNA uptake.
A region based approach for the identification of hardware Trojans (2008)

Outsourcing of SoC fabrication units has created the potential threat of design tampering using hardware Trojans. Methods based on side-channel analysis exist to differentiate such maligned ICs from the genuine ones but process variation in the foundries limit the effectiveness of such approaches. In this work, we propose a circuit partition based approach to detect and locate the embedded Trojan. Results show that our approach is effective in separating out candidate Trojans in the circuit. In addition, we provide a power profile based method for refining the candidate regions that may contain a Trojan. In many cases, such an isolation method leads to noticeable manifestation of the anomalous behavior of the circuit due to the presence of the Trojan thereby enhancing chances of their detection.
p16/CDKN2 andCDK4 gene mutations in sporadic melanoma development and progression (1997)

The p16/CDKN2(MTS1) gene encoding for the p16 inhibitor of cyclin D/CDK4 complexes is frequently mutated and deleted in a large fraction of melanoma cell lines, and p16 germline mutations have also been observed in familial melanomas. Moreover, a CDK4 gene mutation, responsible for a functional resistance of CDK4 kinase to p16 inhibitory activity, has been described to occur in some cases of familial melanoma. These data strongly support the idea that deregulation of the CDK4/cyclin D pathway, via CDKN2 or CDK4 mutations, is of biological significance in the development of melanoma. To shed light on the role of these alterations in the development and progression of sporadic melanoma, 12 primary melanomas and 9 corresponding metastases were analyzed for CDKN2 and CDK4 gene mutations. Of the 12 primary melanomas analyzed, 4 showed the presence of mutational inactivation of the p 16 protein and 2 carried silent mutations. No metastases showed the presence of CDKN2 mutations, indicating that mutations of this cyclin-dependent kinase inhibitor is not common in the progression of sporadic melanoma. On the other hand, the absence, in the metastases, of the CDKN2 mutation detected in the corresponding primary tumors suggests that 9p21 homozygous deletion may play a major role in the metastatic spreading of this type of tumor. None of the cases analyzed showed the presence of an Arg24Cys mutation, which functionally protects CDK4 from p16 inhibition. This indicates that CDK4 mutation plays a minor role in the development and progression of sporadic melanoma.
Single cardiac cycle three-dimensional intracoronary optical coherence tomography (2016)

While high-speed intracoronary optical coherence tomography (OCT) provides three-dimensional (3D) visualization of coronary arteries <i>in vivo</i>, imaging speeds remain insufficient to avoid motion artifacts induced by heartbeat, limiting the clinical utility of OCT. In this paper, we demonstrate development of a high-speed intracoronary OCT system (frame rate: 500 frames/s, pullback speed: 100 mm/s) along with prospective electrocardiogram (ECG) triggering technology, which enabled volumetric imaging of long coronary segments within a single cardiac cycle (70 mm pullback in 0.7 s) with minimal cardiac motion artifact. This technology permitted detailed visualization of 3D architecture of the coronary arterial wall of a swine <i>in vivo</i> and fine structure of the implanted stent.
The Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptors TRAIL-R1 and TRAIL-R2 Have Distinct Cross-linking Requirements for Initiation of Apoptosis and Are Non-redundant in JNK Activation (2000)

Overexpression of the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors, TRAIL-R1 and TRAIL-R2, induces apoptosis and activation of NF-kappaB in cultured cells. In this study, we have demonstrated differential signaling capacities by both receptors using either epitope-tagged soluble TRAIL (sTRAIL) or sTRAIL that was cross-linked with a monoclonal antibody. Interestingly, sTRAIL was sufficient for induction of apoptosis only in cell lines that were killed by agonistic TRAIL-R1- and TRAIL-R2-specific IgG preparations. Moreover, in these cell lines interleukin-6 secretion and NF-kappaB activation were induced by cross-linked or non-cross-linked anti-TRAIL, as well as by both receptor-specific IgGs. However, cross-linking of sTRAIL was required for induction of apoptosis in cell lines that only responded to the agonistic anti-TRAIL-R2-IgG. Interestingly, activation of c-Jun N-terminal kinase (JNK) was only observed in response to either cross-linked sTRAIL or anti-TRAIL-R2-IgG even in cell lines where both receptors were capable of signaling apoptosis and NF-kappaB activation. Taken together, our data suggest that TRAIL-R1 responds to either cross-linked or non-cross-linked sTRAIL which signals NF-kappaB activation and apoptosis, whereas TRAIL-R2 signals NF-kappaB activation, apoptosis, and JNK activation only in response to cross-linked TRAIL.
Trafficking of immature ΔF508-CFTR to the plasma membrane and its detection by biotinylation (2008)

Recent studies suggest that immature, core-glycosylated DeltaF508-CFTR [the predominant mutant form of the CFTR (cystic fibrosis transmembrane conductance regulator)] can reach the plasma membrane under some conditions. In the present study we investigated this possibility since it has implications for understanding how therapeutics rescue the trafficking of mutant CFTR and perhaps other misfolded proteins. Core-glycosylated CFTR was labelled and pulled down on streptavidin beads after exposure to sulfo-NHS-SS-biotin [biotin attached to a reactive NHS (N-hydroxysuccinimide) ester with a disulfide spacer; molecular mass=606.7 Da]; however, intracellular proteins were also detected in the precipitates. When the R domain of CFTR was expressed in the cytosol of BHK (baby-hamster kidney) cells as a soluble polypeptide it was also labelled after surface biotinylation and pulled down on streptavidin beads. Intracellular biotinylation was reduced when cells were treated with sulfo-NHS-LC-biotin (biotin attached to a reactive NHS ester with an aminocaproic acid spacer) or sulfo-NHS-PEO(12)-biotin [biotin attached to a reactive NHS ester with a poly(ethylene glycol) spacer], but the reduction could be explained by the lower reactivity of these reagents. The R domain was detected on Western blots after loading <0.25% of the pulldown sample ( approximately 0.01% of total lysate protein), a fraction that could be ascribed to cells that were permeable to ethidium homodimer-1 (molecular mass=856.8 Da) and propidium iodide (molecular mass=668.6 Da). When BHK cells were incubated at 29 degrees C to rescue DeltaF508-CFTR trafficking, and then biotinylated and sorted to remove permeable cells, labelling of core-glycosylated DeltaF508-CFTR was no longer detected although a weak signal was still observed using CFBE (cystic fibrosis bronchial epithelial) cells. These results suggest that there is weak surface expression of immature DeltaF508-CFTR on airway epithelial cells and demonstrate the need to remove permeable cells when studying CFTR glycoforms by surface biotinylation.