gebhart/patrepeval huggingface dataset:
An algorithm for combined cell-site selection and power control to maximize cellular spread spectrum capacity (1995)

There is much current interest in spread spectrum wireless mobile communications and in particular the issue of spread spectrum wireless capacity. We characterize spread spectrum cellular capacity and provide a combined power control, cell-site selection algorithm that enables this capacity to be achieved. The algorithm adapts users' transmitter power levels and switches them between cell-sites, and it is shown that the algorithm converges to an allocation of users to cells that is optimal in the sense that interference is minimized. The algorithm is decentralized, and can be considered as a mechanism for cell-site diversity and handover. We provide numerical examples to show how effectively the algorithm relieves local network congestion, by switching users in a heavily congested cell to adjacent, less congested cells.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The DsbA Signal Sequence Directs Efficient, Cotranslational Export of Passenger Proteins to the Escherichia coli Periplasm via the Signal Recognition Particle Pathway (2003)

The Escherichia coli cytoplasmic protein thioredoxin 1 can be efficiently exported to the periplasmic space by the signal sequence of the DsbA protein (DsbAss) but not by the signal sequence of alkaline phosphatase (PhoA) or maltose binding protein (MBP). Using mutations of the signal recognition particle (SRP) pathway, we found that DsbAss directs thioredoxin 1 to the SRP export pathway. When DsbAss is fused to MBP, MBP also is directed to the SRP pathway. We show directly that the DsbAss-promoted export of MBP is largely cotranslational, in contrast to the mode of MBP export when the native signal sequence is utilized. However, both the export of thioredoxin 1 by DsbAss and the export of DsbA itself are quite sensitive to even the slight inhibition of SecA. These results suggest that SecA may be essential for both the slow posttranslational pathway and the SRP-dependent cotranslational pathway. Finally, probably because of its rapid folding in the cytoplasm, thioredoxin provides, along with gene fusion approaches, a sensitive assay system for signal sequences that utilize the SRP pathway.
Gesture recognition as ubiquitous input for mobile phones (2008)

A ubiquitous input mechanism utilizing gesture recognition techniques on a mobile phone is presented. Possible appli-cations using readily available hardware are suggested and the effects of a mobile gaming system on perception is dis-cussed. Author Keywords ubiquitous computing, accelerometers, gesture recognition, optimization, human-computer interfaces ACM Classification Keywords B.4.2 Input/Output Devices, H5.m. Information interfaces and presentation
Control of Service Context using SIP Request-URI (2001)

This memo provides information for the Internet community. It describes a useful way to conceptualize the use of the standard SIP (Session Initiation Protocol) Request-URI (Uniform Resource Identifier) that the authors and many members of the SIP community think is suitable as a convention. It does not define any new protocol with respect to RFC 2543.
<title>Miniaturization of ultra-high-throughput screening assays into 1536-well format</title> (2002)

Assay miniaturization and the implementation of high-density 1536 micro-well screening increases the speed and efficiency of screening and lead discovery. To serve this need, a platform of miniaturizable assay technologies has been assembled for specific biological targets. This platform will enable initiation and completion of uHTS screens in a straightforward and expeditious manner. For kinases, we have examined assays using several technologies including DELFIA, HTR-FRET, FP, EFC, and FMAT. This presentation compares these technologies for the measurement of typical tyrosine kinase activity in 1536-well format. Quality parameters such as assay reproducibility, signal: background ratio, Z factor, and assay sensitivity were calculated and compared. Additionally, the relative merits of each of these technologies were assessed in terms of assay miniaturization, ease of development, ultimate screening capability, efficiency, and cost.
Damage‐associated molecular patterns stimulate interleukin‐33 expression in nasal polyp epithelial cells (2013)

Tissue damage is a nonspecific trigger of epithelial IL-33 production in treatment-recalcitrant polyps, which may be responsible for perpetuating eosinophilic inflammation in CRSwNP. This common pathway may help explain why multiple environmental and infectious agents have been implicated in CRSwNP exacerbation.
Keys for XML (2001)

We discuss the denition of keys for XML documents, paying particular attention to the concept of a relative key, which is commonly used in hierarchically structured documents and scientic databases.
Uptake of fibrillar β-amyloid by microglia isolated from MSR-A (type I and type II) knockout mice (2001)

To characterize the receptors involved in binding fibrillar amyloid A-beta (fA beta), we compared the uptake of fA beta in microglia from wildtype (MSR-A+/+) and MSR-A knockout (MSR-A-/-) mice. On average, there was a 60% reduction in the uptake of Cy3-fA beta in microglia from the MSR-A-/- mice. Cy3-fA beta uptake in the MSR-A-/- mice was still competable by scavenger receptor ligands, including acetylated low-density lipoprotein (Ac-LDL) and fucoidan. This indicates that uptake by MSR-B and/or other MSRs is also involved in the uptake of fA beta by microglia. However, the significant reduction in the uptake of fA beta in the MSR-A-/- microglia suggests that fA beta gets internalized mostly by MSR-As in microglia. Uptake of modified fA beta (ClqA beta) was similar in the MSR-A-/- microglia as in the wildtype indicating that the uptake of the opsonized fA beta is independent of MSR-A.
<title>Alignment-controlled holographic polymer dispersed liquid crystal (HPDLC) for reflective display devices</title> (1998)

A new type of holographic polymer dispersed liquid crystal (HPDLC) device in which liquid-crystal (LC) alignment is controlled by polymer layers has been developed. An LC containing light-curable prepolymer was placed between two substrates with anti-parallel alignment layers and cured using the interferential fringes of Ar<SUP>+</SUP> laser light. Photo- polymerization occurred at the peaks of the interferential fringes and polymer networks were formed. LC layers formed at the nodes of the fringes. The LC molecules contained in the polymer layers were fixed so that they were aligned parallel to the substrates. Therefore, the polymer layers could be used to control the LC molecules in the LC layers and act as alignment layers. This alignment-controlled HPDLC device has a possibility to make effective use of the refractive index anisotropy of the LC. The fundamental operation of the alignment-controlled HPDLC device has been confirmed experimentally.
Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD (2006)

Fish intake, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and in some cases alpha-linolenic acid (ALA) have been associated with reduced risk of cardiovascular events and death. The association between n-3 fatty acids in plasma lipids and the progression of coronary artery atherosclerosis was assessed among women with established coronary artery disease (CAD). A prospective cohort study involved postmenopausal women (n = 228) participating in the Estrogen Replacement and Atherosclerosis Trial. Quantitative coronary angiography was performed at baseline and after 3.2 +/- 0.6 (mean +/- SD) years. Women with plasma phospholipid (PL) DHA levels above the median, compared with below, exhibited less atherosclerosis progression, as expressed by decline in minimum coronary artery diameter (-0.04 +/- 0.02 and -0.10 +/- 0.02 mm, respectively; P = 0.007) or increase in percentage stenosis (1.34 +/- 0.76% and 3.75 +/- 0.74%, respectively; P = 0.006), and had fewer new lesions [2.0% (0.5-3.5%) of measured segments (95% confidence interval) and 4.2% (2.8-5.6%), respectively; P = 0.009] after adjustments for cardiovascular risk factors. Similar results were observed for DHA in the triglycerides (TGs). EPA and ALA in plasma lipids were not significantly associated with atherosclerosis progression. Consistent with higher reported fish intake, higher levels of plasma TG and PL DHA are associated with less progression of coronary atherosclerosis in postmenopausal women with CAD.
Anti-Amyloid-β Immunotherapy in Alzheimer's Disease: Relevance of Transgenic Mouse Studies to Clinical Trials (2008)

Therapeutic approaches to the treatment of Alzheimer's disease are focused primarily on the amyloid-beta peptide which aggregates to form amyloid deposits in the brain. The amyloid hypothesis states that amyloid is the precipitating factor that results in the other pathologies of Alzheimer's disease. One such therapy that has attracted significant attention is anti-amyloid-beta immunotherapy. First described in 1999, immunotherapy uses anti-amyloid-beta antibodies to lower brain amyloid levels. Active and passive immunization were shown to lower brain amyloid levels and improve cognition in multiple transgenic mouse models. Mechanisms of action were studied in these mice and revealed a complex set of mechanisms that depended on the type of antibody used. When active immunization advanced to clinical trials a subset of patients developed meningoencephalitis, an event not predicted in mouse studies. It was suspected that a T-cell response due to the type of adjuvant used was the cause. Passive immunization has also advanced to Phase III clinical trials on the basis of successful transgenic mouse studies. Reports from the active immunization clinical trial indicated that, similarly to effects observed in mouse studies, amyloid levels in brain were reduced.
Low-complexity modified Mastrovito multipliers over finite fields GF(2/sup M/) (2003)

This paper considers the design of low-complexity dedicated finite field multipliers. A modified Mastrovito multiplication scheme is proposed in this paper, which has a complexity proportional to (m-1-pwt), where pwt is the Hamming weight of the underlying irreducible polynomial. With this modified multiplier and the original Mastrovito multiplier, low-complexity parallel multipliers for finite fields GF(2/sup M/) can be designed with complexity proportional to min{pwt, m-1-pwt}, hence are good for irreducible polynomials of both low and high Hamming weights. This completes the design space and offers more freedom on polynomial selection. It is shown that this generalized Mastrovito multiplier generally has the lowest complexity, smallest latency and consumes the least power, compared with other standard-basis and dual-basis multipliers.
Moving standards to 100 Gbe and beyond (2007)

There is a need for 100 Gb/s data transport, or 100 Gb Ethernet (100 GbE), for both local area networks (LANs) and wide area networks (WANs). Standardization related to 100 Gb/s is a key next step for Ethernet to continue in its role as a ubiquitous end-to-end protocol. This article describes recent standardization efforts, and activities planned for the future. 100 Gb is a work in progress and this article provides an early snapshot of the standards effort being undertaken mostly by the IEEE 802.3 and its High Speed Study Group (HSSG), which recently approved a project authorization request (PAR) 802.3ba document. In addition, the International Telecommunication Union (ITU-T) is involved in the definition of 100 GbE parameters for transport over the WAN by using the Optical Transport Network (OTN) rates standardized so far. It is critical that 100 GbE efforts progress in an orderly manner to ensure a robust and healthy overall network infrastructure.
Nucleotide sequence of the btuCED genes involved in vitamin B12 transport in Escherichia coli and homology with components of periplasmic-binding-protein-dependent transport systems (1986)

The products of the btuCED region of the Escherichia coli chromosome participate in the transport of vitamin B12 across the cytoplasmic membrane. The nucleotide sequence of the 3,410-base-pair HindIII-HincII DNA fragment carrying a portion of the himA gene and the entire btuCED region was determined. Comparison of the location of the open reading frames with the gene boundaries defined by transposon insertions allowed the assignment of polypeptide products to gene sequences. The btuC product is a highly nonpolar integral membrane protein of molecular weight 31,683. The distribution of hydrophobic regions suggests the presence of numerous membrane-spanning domains. The btuD product is a relatively polar but membrane-associated polypeptide of Mr 27,088 and contains segments bearing extensive homology to the ATP-binding peripheral membrane constituents of periplasmic binding protein-dependent transport systems. Other regions of this protein are similar to portions of the outer membrane vitamin B12 receptor. The btuE product (Mr 20,474) appears to have a periplasmic location. It has the mean hydropathy of a soluble protein but lacks an obvious signal sequence. The cellular locations and structural and sequence homologies of the Btu polypeptides point to the similarity of these three proteins to components of binding protein-dependent transport systems. However, the dependence on a periplasmic vitamin B12-binding protein has not yet been demonstrated.
Characterization of an activated human ros gene. (1986)

A human oncogene, mcf3, previously detected by a combination of DNA-mediated gene transfer and a tumorigenicity assay, derives from a human homology of the avian v-ros oncogene. Both v-ros and mcf3 can encode a protein with homology to tyrosine-specific protein kinases, and both mcf3 and v-ros encode a potential transmembrane domain N terminal to the kinase domain. mcf3 probably arose during gene transfer from a normal human ros gene by the loss of a putative extracellular domain. There do not appear to be any other gross rearrangements in the structure of mcf3.
Analysis of Qa-2 Antigen Expression by Preimplantation Mouse Embryos: Possible Relationship to the Preimplantation-Embryo-Development (Ped) Gene Product1 (1987)

The preimplantation-embryo-development (Ped) gene, a gene that controls the cleavage rate of preimplantation mouse embryos, maps to the Qa-2 subregion of the mouse major histocompatibility complex (MHC). A highly sensitive enzyme-linked immunosorbent assay (ELISA) procedure was used to detect Qa-2 antigens on mouse embryos. The use of a monoclonal antibody specific for Qa-2 antigens showed that Qa-2 antigens were present on oocytes, 2-cell, 8-cell, and blastocyst-stage embryos, with the greatest expression found on blastocysts. Expression of Qa-2 antigens by the embryos correlated completely with Ped gene phenotype. Those embryos expressing the fast Ped allele showed the presence of Qa-2 antigens (Qa-2a mice), whereas those embryos expressing the slow Ped allele showed the absence of Qa-2 antigens (Qa-2b mice). It is hypothesized that the Qa-2 antigen may be the Ped gene product.
Preoperative chemoradiotherapy for oesophageal cancer: a systematic review and meta-analysis (2004)

In patients with resectable oesophageal cancer, chemoradiotherapy plus surgery significantly reduces three year mortality compared with surgery alone. However, postoperative mortality was significantly increased by neoadjuvant chemoradiotherapy. Further large scale multicentre RCTs may prove useful to substantiate the benefit on overall survival.
A technique of scatter‐glare correction using a digital filtration (1993)

A scatter-glare correction technique for x-ray images acquired with an antiscatter grid was developed. In the technique, the scatter-glare image was estimated from exposure conditions and subtracted from the acquired image. The basic procedure in the estimation of the scatter-glare image is convolution filtering; however, the novel aspects of the technique are as follows: (1) To estimate the scatter-glare intensity, a formula that does not include the term of object thickness was used. With this formula, the correction can be performed, even for nonuniform phantoms; (2) To estimate the scatter-glare distribution, the experimental scatter-glare point spread function (PSF) was directly used as a convolution kernel. Although the shape of the PSF changed slightly for water thicknesses of 5-25 cm, we applied the PSF measured at a water thickness of 15 cm to the correction experiments. For the stepped water phantom (10-20 cm), scatter-glare estimation produced an average error of 10%, with respect to the lead bar data. Furthermore, the improvement of image quality and quantitative accuracy resulting from the correction was examined.
Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies (2015)

A potential strategy to alleviate the aggregation of intrinsically disordered proteins (IDPs) is to maintain the native functional state of the protein by small molecule binding. However, the targeting of the native state of IDPs by small molecules has been challenging due to their heterogeneous conformational ensembles. To tackle this challenge, we applied a high-throughput chemical microarray surface plasmon resonance imaging screen to detect the binding between small molecules and monomeric full-length Tau, a protein linked with the onset of a range of Tauopathies. The screen identified a novel set of drug-like fragment and lead-like compounds that bound to Tau. We verified that the majority of these hit compounds reduced the aggregation of different Tau constructs in vitro and in N2a cells. These results demonstrate that Tau is a viable receptor of drug-like small molecules. The drug discovery approach that we present can be applied to other IDPs linked to other misfolding diseases such as Alzheimer's and Parkinson's diseases.
Determination of Bandgap and Energy Band Alignment for High-Dielectric-Constant Gate Insulators Using High-Resolution X-ray Photoelectron Spectroscopy (1999)

1999 International Conference on Solid State Devices and Materials,Determination of Bandgap and Energy Band Alignment for High-Dielectric-Constant Gate Insulators Using High-Resolution X-ray Photoelectron Spectroscopy
Role of bound calcium ions in thermostable, proteolytic enzymes. Separation of intrinsic and calcium ion contributions to the kinetic thermal stability (1976)

&lt;P&gt;Abstract copyright UK Data Service and data collection copyright owner.&lt;/P&gt;&lt;p&gt;The Opinions and Lifestyle Survey (OPN) is an omnibus survey that collects data on a range of subjects commissioned by both the ONS internally and external clients (limited to&amp;nbsp;other government departments, charities, non-profit organisations and academia).&lt;/p&gt;\n&lt;p&gt;Data are collected from one individual aged 16&amp;nbsp;or&amp;nbsp;over,&amp;nbsp;selected from each sampled private household. Personal data include data on the individual, their family, address, household, income and education, plus responses and opinions on a variety of subjects within commissioned modules.&lt;/p&gt;\n&lt;p&gt;The questionnaire collects timely data for research and policy analysis evaluation on the social impacts of recent topics of national importance, such as the coronavirus (COVID-19) pandemic and the cost of living, on individuals and households in Great Britain.&lt;/p&gt;\n&lt;p&gt;From April 2018 to November 2019, the design of the OPN changed from face-to-face to a mixed-mode design (online first with telephone interviewing where necessary). Mixed-mode collection allows respondents to complete the survey more flexibly and provides a more cost-effective service for customers.&lt;/p&gt;\n&lt;p&gt;In March 2020, the OPN was adapted to become a weekly survey used to collect data on the social impacts of the coronavirus (COVID-19) pandemic on the lives of people of Great Britain. These data are held in the Secure Access study, SN 8635,&amp;nbsp;&lt;em&gt;ONS Opinions and Lifestyle Survey, Covid-19 Module, 2020-2022: Secure Access.&amp;nbsp;&lt;/em&gt;Other Secure Access OPN data cover modules run at various points from 1997-2019, on Census religion (SN 8078), cervical cancer screening (SN 8080), contact after separation (SN 8089), contraception (SN 8095), disability (SNs 8680 and 8096), general lifestyle (SN 8092), illness and activity (SN 8094), and non-resident parental contact (SN 8093).&lt;/p&gt;\n&lt;p&gt;From August 2021, as coronavirus (COVID-19) restrictions were lifting across Great Britain, the OPN moved to fortnightly data collection, sampling around 5,000 households in each survey wave to ensure the survey remains sustainable.&lt;/p&gt;\n&lt;p&gt;The OPN has since expanded to include questions on other topics of national importance, such as health and the cost of living. For more information about the survey and its methodology, see the ONS&amp;nbsp;&lt;a title="OPN Quality and Methodology Information" href="https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/healthandlifeexpectancies/methodologies/opinionsandlifestylesurveyqmi"&gt;OPN Quality and Methodology Information&lt;/a&gt; webpage.&lt;/p&gt;
Unique Toll-Like Receptor 4 Activation by NAMPT/PBEF Induces NFκB Signaling and Inflammatory Lung Injury (2015)

Ventilator-induced inflammatory lung injury (VILI) is mechanistically linked to increased NAMPT transcription and circulating levels of nicotinamide phosphoribosyl-transferase (NAMPT/PBEF). Although VILI severity is attenuated by reduced NAMPT/PBEF bioavailability, the precise contribution of NAMPT/PBEF and excessive mechanical stress to VILI pathobiology is unknown. We now report that NAMPT/PBEF induces lung NFκB transcriptional activities and inflammatory injury via direct ligation of Toll-like receptor 4 (TLR4). Computational analysis demonstrated that NAMPT/PBEF and MD-2, a TLR4-binding protein essential for LPS-induced TLR4 activation, share ~30% sequence identity and exhibit striking structural similarity in loop regions critical for MD-2-TLR4 binding. Unlike MD-2, whose TLR4 binding alone is insufficient to initiate TLR4 signaling, NAMPT/PBEF alone produces robust TLR4 activation, likely via a protruding region of NAMPT/PBEF (S402-N412) with structural similarity to LPS. The identification of this unique mode of TLR4 activation by NAMPT/PBEF advances the understanding of innate immunity responses as well as the untoward events associated with mechanical stress-induced lung inflammation.
14-3-3 Proteins: Active Cofactors in Cellular Regulation by Serine/Threonine Phosphorylation (2002)

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