gebhart/patrepeval huggingface dataset:
A landscape of Big data analytics in Supply chain planning: completing the puzzle and vision to the future (2019)

Despite the boom of research interest at the intersection of big data and supply chain domain, little research effort has been directed to investigate big data analytics (BDA) for the planning processes of supply chains. This paper aims to draw the landscape of current knowledge regarding the use of BDA in supply chain planning (SCP) and to provide a vision for future research. Based on a systematic literature review of 51 peer-reviewed papers published between 2013 and February 2019, we organized the literature according to the SCP process with the "supply chain planning matrix”, and studied the managerial issues related to BDA adoption in SCP. Results highlight that extant literature is dominant by the use of BDA in demand planning and production planning and scheduling, while other planning activities are relatively under-investigated. Most of the studies are restricted to the investigation of BDA in a single planning phase, where the supply chain perspective is weak. Finally, we suggest that empirical studies are in need to bridge academic and practitioner studies on the theme.
Reactivity of cytosine and thymine in single-base-pair mismatches with hydroxylamine and osmium tetroxide and its application to the study of mutations. (1988)

The chemical reactivity of thymine (T), when mismatched with the bases cytosine, guanine, and thymine, and of cytosine (C), when mismatched with thymine, adenine, and cytosine, has been examined. Heteroduplex DNAs containing such mismatched base pairs were first incubated with osmium tetroxide (for T and C mismatches) or hydroxylamine (for C mismatches) and then incubated with piperidine to cleave the DNA at the modified mismatched base. This cleavage was studied with an internally labeled strand containing the mismatched T or C, such that DNA cleavage and thus reactivity could be detected by gel electrophoresis. Cleavage at a total of 13 T and 21 C mismatches isolated (by at least three properly paired bases on both sides) single-base-pair mismatches was identified. All T or C mismatches studied were cleaved. By using end-labeled DNA probes containing T or C single-base-pair mismatches and conditions for limited cleavage, we were able to show that cleavage was at the base predicted by sequence analysis and that mismatches in a length of DNA could be readily detected by such an approach. This procedure may enable detection of all single-base-pair mismatches by use of sense and antisense probes and thus may be used to identify the mutated base and its position in a heteroduplex.
Studies on In Vitro Transformation by DNA and DNA Fragments of Human Adenoviruses and Simian Virus 40 (1974)

There is considerable evidence suggesting that only part of the genome of the DNA tumor viruses is involved in oncogenic transformation: (1) The transforming activity of these viruses is much more resistant to inactivation by radiation and chemicals than is the infectivity, indicating that a considerable part of the viral genome is not required for transformation (Benjamin 1965; Yamamoto 1970). (2) Usually only the early viral gene functions are expressed in transformed cells (Ozanne et al. 1973; Green et al. 1970). (3) Studies with temperature-sensitive mutants have shown that late mutants are normal with respect to transformation at the restrictive temperature, and there is evidence that in the case of polyoma virus and simian virus 40 (SV40) only one or two gene functions are required for transformation (Eckhart 1969; Eckhart et al. 1971; Tegtmeyer and Ozer 1971). (4) Cells transformed by adenovirus type 2 contain only a part of the...
A checkpoint for autoreactivity in human IgM+ memory B cell development (2006)

Autoantibodies are removed from the repertoire at two checkpoints during B cell development in the bone marrow and the periphery. Despite these checkpoints, up to 20% of the antibodies expressed by mature naive B cells in healthy humans show low levels of self-reactivity. To determine whether self-reactive antibodies are also part of the antigen-experienced memory B cell compartment, we analyzed recombinant antibodies cloned from single circulating human IgM+ memory B cells. Cells expressing antibodies specific for individual bacterial polysaccharides were expanded in the IgM+ memory compartment. In contrast, B cells expressing self-reactive and broadly bacterially reactive antibodies were removed from the repertoire in the transition from naive to IgM+ memory B cell. Selection against self-reactive antibodies was implemented before the onset of somatic hypermutation. We conclude that a third checkpoint selects against self-reactivity during IgM+ memory B cell development in humans.
Application of carbon nanotubes as electrodes in gas discharge tubes (2000)

Gas-tube protector units are used in telecom network interface device boxes and central office switching gears to provide protection from lightning and alternating current power cross faults on the telecom network. Current gas discharge tube (GDT) protector units are unreliable from the standpoint of mean turn-on voltage and run-to-run variability. Molybdenum electrodes with various interlayer materials were coated with single-walled carbon nanotubes and analyzed for both electron field emission and discharge properties. A mean direct current breakdown voltage of 448.5 V and a standard deviation of 4.8 V over 100 surges were observed in nanotube-based GDTs with 1 mm gap spacing between the electrodes. The breakdown reliability is a factor of 4–20 better and the breakdown voltage is ∼30% lower than the two commercial products measured. The enhanced performance shows that nanotube-based GDTs are attractive overvoltage protection units in advanced telecom networks.
Polyimide derived from 2,2'-bis(trifluoromethyl)-4,4'-diaminobiphenyl. 1. Synthesis and characterization of polyimides prepared with 2,2'-bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride or pyromellitic dianhydride (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolyimide derived from 2,2'-bis(trifluoromethyl)-4,4'-diaminobiphenyl. 1. Synthesis and characterization of polyimides prepared with 2,2'-bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride or pyromellitic dianhydrideTohru Matsuura, Yoshinori Hasuda, Shiro Nishi, and Noriyoshi YamadaCite this: Macromolecules 1991, 24, 18, 5001–5005Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/ma00018a004https://doi.org/10.1021/ma00018a004research-articleACS PublicationsRequest reuse permissionsArticle Views3699Altmetric-Citations350LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pathophysiology, Treatment and Outcome of Meningococcemia: A Review and Recent Experience (1996)

KIRSCH, ERICA A. MD; BARTON, R. PHILLIP MD; KITCHEN, LOUANN RN,MS; GIROIR, BRETT P. MD Author Information
<i>Corynebacterium glutamicum</i> Glyceraldehyde-3-Phosphate Dehydrogenase Isoforms with Opposite, ATP-Dependent Regulation (2004)

Corynebacterium glutamicum gapA and gapB encode glyceraldehyde-3-phosphate dehydrogenases (GAPDHs) that differ in molecular weight and activity in the presence of ATP. Comparative genome analysis revealed that GapA, the product of gapA, represented the canonical GAPDH that is highly conserved across the three major life forms. GapB, with an additional 110-residue-long sequence upstream of its GAPDH-specific domain, was homologous only to select microbial putative GAPDHs. Upon gene disruption, the initial growth rates of the wild-type, DeltagapA and DeltagapB strains on glucose (0.77, 0.00 and 0.76 h(-1), respectively), lactate (0.20, 0.18 and 0.15 h(-1), respectively), pyruvate (0.39, 0.29 and 0.20 h(-1), respectively), and acetate (0.06, 0.06 and 0.04 h(-1), respectively), implied that GapA was indispensable for growth on glucose, that GapB, but not GapA, affected early growth on acetate, and that GapB had a greater influence on growth under gluconeogenic conditions than GapA. The disruption of either gapA or gapB showed no significant effect on the transcription of any of the other gap cluster genes although it led to reduced triosephosphate isomerase (TPI) activities. Glycolytic GAPDH activity at low in vitro ATP concentrations was solely attributed to the 35.9-kDa GapA. At higher ATP concentrations, the same activity was attributed to the 51.2-kDa GapB. Both enzymes, however, exhibited similar NADP-dependent GAPDH activities at the higher ATP concentrations. In effect therefore, the GAPDH-catalyzed reaction at low ATP concentrations was irreversible, with all the glycolytic activity strictly NAD-dependent and attributed to GapA. At higher ATP concentrations, the reaction was reversible, with glycolytic activity NAD- or NADP-dependent and attributed to GapB, while gluconeogenic activity was attributable to both GapA and GapB.
Integrated-optic variable delay line and its application to a low-coherence reflectometer (2005)

We propose a large-scale variable delay line based on planar light-wave circuit technology and its application as a reference arm in an optical low-coherence reflectometer. This variable delay line is composed of 16 asymmetrical delay arm pairs sandwiched between 2 optical switches, which select the path for a needed delay. This configuration enables us to eliminate the need for a moving part in the reflectometer. We can scan the reference arm over a length of 262.1 mm with a step of less than 1.0 microm in air and achieve reflectometer sensitivity of about -47 dB.
Correspondence (1990)

Journal Article Correspondence Get access George Martin George Martin Search for other works by this author on: Oxford Academic Google Scholar The Opera Quarterly, Volume 7, Issue 3, AUTUMN 1990, Pages 217-a–217, https://doi.org/10.1093/oq/7.3.217-a Published: 01 October 1990
The Presence of Antibodies Recognizing a Peptide Derived from the Second Conserved Region of HIV-1 gp120 Correlates with Non-Progressive HIV Infection (2007)

The C-terminus of the second conserved region of HIV-1 gp120 represents a functionally important domain, as it encompasses amino acids directly involved in the binding to the CD4 receptor and in post-receptor binding events. Previous studies have suggested that antibodies with specific affinity to a 23 amino acids-long NTM polypeptide, derived from this HIV-1 gp120 domain, may be involved in the control of HIV disease progression. In the current work, we searched for NTM-recognizing antibodies in specific cohorts of HIV-1 infected individuals, including long-term nonprogressors (LTNP) and progressors. For this purpose, we employed a previously defined bioinformatics criterion for design of an NTM peptide mimetic to select an octapeptide, NTMs (FTDNAKTI), which is more suitable for use in a solid-state enzyme-linked immunosorbent assay (ELISA). Our results show that NTMs-reactive antibodies are significantly more prevalent (p < 0.01) in LTNP as compared to progressors and healthy control subjects, indicating their association with non-progressive infection. The presence of antibodies recognizing the second conserved region of the HIV-1 gp120 derived peptide, NTMs, in LTNP sera suggest that these antibodies could be of considerable interest for development of anti-HIV immune-based therapies and vaccines.
Time-stretched analog-to-digital conversion (TSADC) (2003)

Summary form only given. The ability to perform ultrafast A/D and D/A conversion is critical for high performance communication and radar systems. Challenges with traditional approaches have led us to propose the concept of time-stretch preprocessing as a possible solution to the ultrafast A/D conversion. In Nyquist type A/D converters (ADCs) time stretching increases the effective input bandwidth and sampling rate of the ADC. In /spl Sigma/-/spl Delta/ type converters, it has the additional benefit of reducing the quantization noise within the signal bandwidth. In this paper, we will present the experimental data and theoretical analysis for time-manipulation of electrical signal using optoelectronic techniques. We also introduce a new discrete-time rendition of this technique with near transform-limited temporal resolution. Analytical and numerical calculation of the fundamental limits of this approach will be presented. We will conclude by presenting an overview of the COAST (Consortium for Optical A/D System Technology), a new DARPA funded UCLA-lead consortium consisting of 8 Universities, industry and national laboratories dedicated to research in optically assisted A/D conversion.
A Fully-Integrated +23-dBm CMOS Triple Cascode Linear Power Amplifier with Inner-Parallel Power Control Scheme (2006)

The low oxide breakdown voltage of CMOS power transistor and low power-added efficiency (PAE) at low power levels have been major challenging issues in the implementation of high-power linear power amplifiers (PAs), especially in deep sub-micron CMOS technology. In order to alleviate these problems, a triple cascode CMOS PA with inner-parallel power control scheme is presented. The proposed PA, fully-integrated in 0.18/spl mu/m CMOS technology, delivers an output power of 23dBm with 35% PAE at 3.3V supply voltage. Since the thin-oxide transistors of the minimum feature size can be utilized as power transistors in the proposed PA, a high power gain of 19dB has been achieved even at single-stage. And PAE at an 8dB-backoff from the 1dB compression point (P/sub 1dB/) of 20dBm has been measured as high as 12%.
In situ molecular association of dystrophin with actin revealed by sensitized emission immuno-resonance energy transfer (1997)

A novel method was developed to detect molecular associations of dystrophin with actin in cryostat muscle tissue sections by combining resonance energy transfer technology with immunohistochemical techniques. This method takes advantage of the long phosphorescent lifetime of terbium chelates, a property that enables the accurate determination of energy transfer in biological tissues by lifetime measurements of sensitized emission. After a brief excitation pulse, terbium chelates emit for milliseconds after the intrinsically high autofluorescence of biological specimens has decayed to negligible levels. Rat skeletal muscle tissue sections were labeled with both anti-dystrophin monoclonal antibody conjugated to a terbium-based resonance energy transfer donor and anti-actin tetramethylrhodamine phalloidin as an acceptor. Resonance energy transfer between the two probes indicated that the distance separating the probes is within 10 nm (about the size of an IgG2b antibody molecule). The fraction of antibodies that participated in resonance energy transfer was estimated to be 80-90% because of the close agreement between the quenching of donor phosphorescence and the efficiency of resonance energy transfer revealed by lifetime measurements of sensitized emission by tetramethyl-rhodamine phalloidin. Sensitized emission was detectable only when both anti-dystrophin antibody and tetramethyl-rhodamine phalloidin were present. These results indicate that actin and dystrophin are closely associated within the cell. This method is potentially applicable to the investigation of many types of intracellular associations.
GaAs Twin-Laser Setup to Measure Mode and Material Dispersion in Optical Fibers (1974)

Two synchronously self-pulsing GaAlAs lasers, emitting at slightly different wavelengths, are combined in a setup which evaluates mode and material dispersion in multimode fibers. The results show that material dispersion which causes a pulse broadening of 3.6 ns/km, which may represent a serious limit to the bit rates achievable in a multimode fiber system using an LED source.
Simple monitoring technique for WDM networks (1999)

A simple technique is proposed that could be used to monitor the wavelengths and optical powers of WDM signals simultaneously. The proposed technique was used to monitor the wavelengths and optical powers of a 16-channel WDM system with accuracy better than ± 3 GHz and ± 0.4 dB, respectively.
Cloned Fragment of the Hepatitis Delta Virus RNA Genome: Sequence and Diagnostic Application (1986)

Hepatitis delta virus (HDV) is a replication-defective etiological agent of hepatitis that requires hepatitis B virus (HBV) as a helper. A complementary DNA (cDNA) fragment of the RNA genome of HDV was cloned into the plasmid vector pBR322, and the primary nucleotide sequence and predicted protein products of the cDNA fragment were determined. This cloned cDNA fragment has been used as a sensitive radioactive probe for the detection of HDV RNA in the serum of patients with either acute or chronic HDV infections.
PHOTOCHEMISTRY and PHOTOBIOLOGY OF MELANOGENIC METABOLITES: FORMATION OF FREE RADICALS* (1987)

Abstract Normal melanocytes produce specialized subcellular organelles called melanosomes within which the biochemical processes of melanogenesis occurs. During sunlight‐induced melanogenesis, the melanocyte‐specific enzyme tyrosinase catalyzes the oxidative polymerization of 3,4‐dihydroxyphenyl‐alanine (DOPA) to melanin. Nucleophilic addition of cysteine to tyrosinase‐generated dopaquinone leads to the formation of cysteinyldopas, precursors of pheomelanin and excreted by‐products of eumelanogenesis. Under conditions of low sulfhydryl content, dopaquinone undergoes a 1,4 intramolecular cycloaddition to yield, after further oxidation, 5,6‐dihydroxyindoles and/or 5,6‐dihydroxy‐2‐carboxyindoles. These indolic melanogenic intermediates and their O ‐methylated metabolites, like cysteinyldopas, are excreted by actively pigmenting as well as dormant melanocytes. Indeed, it has been determined that in humans, the serum and urine concentrations of these melanogenic metabolites increase dramatically following exposure to sunlight, UVA (315‐400 nm), UVB (290‐315 nm) exposure, as well as during PUVA therapy and in melanoma patients, and thus have proved to be excellent biochemical markers of normal and pathological melanocyte function. While controlled light exposure or PUVA therapy generally lead to 100‐300% increases in 5‐S‐cysteinyldopa (5SCD) and 5‐methoxy‐6‐hydroxyindole‐2‐carboxylic acid (6HMICA) serum levels (normal concentration about 4–16 nmol l ‐1 ), the local concentrations in the skin and especially in the actively pigmenting melanocyte may be as high as 200 μ M . Evidence is presented to document that a number of catecholic melanin precursors, including cysteinyldopas and dihydroxyindoles, are photochemically unstable in the presence of biologically relevant ultraviolet radiation (i.e. wavelengths ± 300 nm). Initial photochemical processes involve free radical production; continued photolysis yields polymeric photoproducts. Radicals produced during melanogenic metabolite photolysis have been identified by ESR spin trapping, laser flash photolysis and pulse radiolysis techniques and include hydrated electrons (e aq ), hydrogen atoms (H'), hydroxyl radicals (OH), semiquinones, aryl thiyl (ArS), and alanyl carbon‐based radicals. In vitro investigations of the potential photobiological significance of these reactions have demonstrated photolysis of cysteinyldopas may lead to photoinitiated DNA binding and single strand break induction. The above mentioned radical species may also damage proteins and initiate lipid peroxidation. Definitive evidence for the occurrence of these phototoxic reactions in vivo is currently unavailable, however our in vitro studies suggest a possible role for melanogenic metabolite photolysis in acute and chronic solar responses of human skin.
Reduced Position Effect in Mature Transgenic Plants Conferred by the Chicken Lysozyme Matrix-Associated Region (1994)

, Annelies Loonen, Jos Heldens, Ritsert C. Jansen, Paul Keizer, Willem J. Stiekema, Jan-Peter Nap, Reduced Position Effect in Mature Transgenic Plants Conferred by the Chicken Lysozyme Matrix-Associated Region, The Plant Cell, Vol. 6, No. 3 (Mar., 1994), pp. 417-426
Author cocitation: A literature measure of intellectual structure (1981)

Abstract It is shown that the mapping of a particular area of science, in this case information science, can be done using authors as units of analysis and the cocitations of pairs of authors as the variable that indicates their “distances” from each other. The analysis assumes that the more two authors are cited together, the closer the relationship between them. The raw data are cocitation counts drawn online from Social Scisearch ( Social Sciences Citation Index ) over the period 1972–1979. The resulting map shows (1) identifiable author groups (akin to “schools”) of information science, (2) locations of these groups with respect to each other, (3) the degree of centrality and peripherality of authors within groups, (4) proximities of authors within group and across group boundaries (“border authors” who seem to connect various areas of research), and (5) positions of authors with respect to the map's axes, which were arbitrarily set spanning the most divergent groups in order to aid interpretation. Cocitation analysis of authors offers a new technique that might contribute to the understanding of intellectual structure in the sciences and possibly in other areas to the extent that those areas rely on serial publications. The technique establishes authors, as well as documents, as an effective unit in analyzing subject specialties.
Statistical timing analysis with correlated non-gaussian parameters using independent component analysis (2006)

We propose a scalable and efficient parameterized block-based statistical static timing analysis algorithm incorporating both Gaussian and non-Gaussian parameter distributions, capturing spatial correlations using a grid-based model. As a preprocessing step, we employ independent component analysis to transform the set of correlated non-Gaussian parameters to a basis set of parameters that are statistically independent, and principal components analysis to orthogonalize the Gaussian parameters. The procedure requires minimal input information: given the moments of the variational parameters, we use a Padé approximation-based moment matching scheme to generate the distributions of the random variables representing the signal arrival times, and preserve correlation information by propagating arrival times in a canonical form. For the ISCAS89 benchmark circuits, as compared to Monte Carlo simulations, we obtain average errors of 0.99% and 2.05%, respectively, in the mean and standard deviation of the circuit delay. For a circuit with G gates and a layout with g spatial correlation grids,the complexity of our approach is O(g G).