gebhart/patrepeval huggingface dataset:
Combining multiple classifiers for text categorization (2001)

A major problem facing online information services is how to index and supplement large document collections with respect to a rich set of categories. We focus upon the routing of case law summaries to various secondary law volumes in which they should be cited. Given the large number (> 13,000) of closely related categories, this is a challenging task that is unlikely to succumb to a single algorithmic solution. Our fully implemented and recently deployed system shows that a superior classification engine for this task can be constructed from a combination of classifiers. The multi-classifier approach helps us leverage all the relevant textual features and meta data, and appears to generalize to related classification tasks.
Helium ion microscopy (2014)

Helium ion microcopy based on gas field ion sources represents a new ultrahigh resolution microscopy and nanofabrication technique. It is an enabling technology that not only provides imagery of conducting as well as uncoated insulating nanostructures but also allows to create these features. The latter can be achieved using resists or material removal due to sputtering. The close to free-form sculpting of structures over several length scales has been made possible by the extension of the method to other gases such as neon. A brief introduction of the underlying physics as well as a broad review of the applicability of the method is presented in this review.
Synthesis and Biological Evaluation of Triazolo[4,5-g]quinolines, Imidazo[4,5-g]quinolines and Pyrido[2,3-g]quinoxaline. Part II (2003)

Synthesis of triazolo[4,5-g]quinolines, imidazo[4,5-g]quinolines and pyrido[2,3-g]quinoxaline has been described.Antimycobacterial, antibacterial and antimycotic activity were also reported.Compounds (14) and (IIb) exhibited an interesting antimycobacterial activity (against M. tuberculosis and M. smegmatis).In continuation of our research program devoted to the discovery of pharmacological activities on new three ring heterocycles, 1-7 we recently described the synthesis of imidazo[4,5-g]-(Ia,b) and triazolo[4,5g]quinolines (Ic,d) and pyrido[2,3-g]quinoxalines (IIa,b) of Figure 1. 8
Organic Electroluminescent Devices with 8-Hydroxyquinoline Derivative-Metal Complexes as an Emitter (1993)

Organic electroluminescent (EL) devices with 8-hydroxy-quinoline derivative-metal complexes (Znq 2 , Beq 2 , Mgq 2 , ZnMq 2 , BeMq 2 and AlPrq 3 ) as the emitter have been developed. The emissions of these devices are green or yellow. These devices have a luminance of more than 3000 cd/m 2 . In particular, the EL device with Znq 2 has a luminance of 16200 cd/m 2 .
Tetanus Toxin and Botulinum A and C Neurotoxins Inhibit Noradrenaline Release from Cultured Mouse Brain (1988)

Primary nerve cell cultures from the brainstem of embryonic mice take up [3H]noradrenaline. Release can be evoked by high K+ or sea anemone toxin II and depends on Ca2+. The cultures allow neurochemical studies on the long-term actions of clostridial neurotoxins. Tetanus and botulinum A and C neurotoxins partially inhibit the absolute and fractional release evoked by high K+, as well as the fractional basal release. The detection limit for the toxins is below 5 pM. Total radioactivity is higher in the poisoned cultures, although the initial velocity of uptake is not measurably influenced by tetanus or botulinum A toxin. Pretreatment with neuraminidase prevents the effects of botulinum A toxin and diminishes those of botulinum C and tetanus toxins. Within 6 days, the cultures partially recover from tetanus toxin poisoning. Antitoxin prevents the actions of the toxin, but only slightly promotes recovery. The data indicate close pharmacological analogies between the clostridial neurotoxins.
Paradoxical increase of stimulus to atrium interval despite His-bundle capture during para-Hisian pacing (2009)

Para-Hisian pacing at high output simultaneously captures the His bundle or proximal right bundle, as well as the adjacent ventricular myocardium. At lower output, direct His-bundle, or right-bundle, capture is lost which causes an increase in the stimulus to atrium interval. We describe a case with an increment of 68 ms with capture of the His bundle. This seems to be a paradoxical response, which however can be explained by the presence of retrograde dual AV-node physiology. Continuation of this phenomenon could be related to concealed anterograde invasion of the fast pathway thereby maintaining the retrograde activation during para-Hisian pacing on the slow pathway despite paced cycle lengths (His to His intervals) where retrograde fast pathway conduction proved to be possible.
Dipeptidyl peptidase IV activity in stimulated T lymphocytes (1988)

Conference Article| June 01 1988 Dipeptidyl peptidase IV activity in stimulated T lymphocytes DIRK HENDRIKS; DIRK HENDRIKS *Unit of Clinical Biochemistry, Faculty of Medicine, University of Antwerp, B-2610 Wilrijk, Belgium Search for other works by this author on: This Site PubMed Google Scholar INGRID DE MEESTER; INGRID DE MEESTER *Unit of Clinical Biochemistry, Faculty of Medicine, University of Antwerp, B-2610 Wilrijk, Belgium Search for other works by this author on: This Site PubMed Google Scholar TEHILA UMIEL; TEHILA UMIEL †Department of Pediatric Hematology and Oncology, Beilinson, Medical Centre, Petah-Tikva, Sackler School of Medicine, Tel-Aviv University, Israel Search for other works by this author on: This Site PubMed Google Scholar GREET VANHOOF; GREET VANHOOF *Unit of Clinical Biochemistry, Faculty of Medicine, University of Antwerp, B-2610 Wilrijk, Belgium Search for other works by this author on: This Site PubMed Google Scholar SIMON SCHARPÉ; SIMON SCHARPÉ *Unit of Clinical Biochemistry, Faculty of Medicine, University of Antwerp, B-2610 Wilrijk, Belgium Search for other works by this author on: This Site PubMed Google Scholar ARIEH YARON ARIEH YARON ‡Department of Biophysics, The Weizmann Institute of Science, Rehovot, Israel Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1988) 16 (3): 365–366. https://doi.org/10.1042/bst0160365 Article history Received: November 30 1987 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation DIRK HENDRIKS, INGRID DE MEESTER, TEHILA UMIEL, GREET VANHOOF, SIMON SCHARPÉ, ARIEH YARON; Dipeptidyl peptidase IV activity in stimulated T lymphocytes. Biochem Soc Trans 1 June 1988; 16 (3): 365–366. doi: https://doi.org/10.1042/bst0160365 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: DAP IV, dipeptidyl peptidase IV, PHA. phytohaemagglutinin This content is only available as a PDF. © 1988 Biochemical Society1988 Article PDF first page preview Close Modal You do not currently have access to this content.
Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos (2007)

Homing endonuclease genes (HEGs) are 'selfish' genetic elements that combine the capability to selectively disrupt specific gene sequences with the ability to rapidly spread from a few individuals to an entire population through homologous recombination repair events. Because of these properties, HEGs are regarded as promising candidates to transfer genetic modifications from engineered laboratory mosquitoes to wild-type populations including Anopheles gambiae the vector of human malaria. Here we show that I-SceI and I-PpoI homing endonucleases cleave their recognition sites with high efficiency in A. gambiae cells and embryos and we demonstrate HEG-induced homologous and non-homologous repair events in a variety of functional assays. We also propose a gene drive system for mosquitoes that is based on our finding that I-PpoI cuts genomic rDNA located on the X chromosome in A. gambiae, which could be used to selectively incapacitate X-carrying spermatozoa thereby imposing a severe male-biased sex ratio.
Escherichia coli K-12: a cooperatively developed annotation snapshot--2005 (2006)

The goal of this group project has been to coordinate and bring up-to-date information on all genes of Escherichia coli K-12. Annotation of the genome of an organism entails identification of genes, the boundaries of genes in terms of precise start and end sites, and description of the gene products. Known and predicted functions were assigned to each gene product on the basis of experimental evidence or sequence analysis. Since both kinds of evidence are constantly expanding, no annotation is complete at any moment in time. This is a snapshot analysis based on the most recent genome sequences of two E.coli K-12 bacteria. An accurate and up-to-date description of E.coli K-12 genes is of particular importance to the scientific community because experimentally determined properties of its gene products provide fundamental information for annotation of innumerable genes of other organisms. Availability of the complete genome sequence of two K-12 strains allows comparison of their genotypes and mutant status of alleles.
Hyperinsulinism in patients with coronary artery disease. (1994)

Knowledge of the fasting insulin level is an important contribution to the identification of patients with, or at risk of, CAD.
Sequencing of Antibodies (2003)

Several antireceptor monoclonal antibodies (MAbs) have been described to compete with ligands for receptor binding. The possibility that structures derived from the hypervariable or complementarity determining regions (CDR) of such antibodies display similarity with those of the ligand binding site of receptors has been documented, thereby allowing the understanding of the structural basis of receptor-ligand interaction. Thus, the determination of the structure of these CDR regions can allow the identification of sequences responsible for the activity of the antibodies.
Anthranilate Synthetase, an Enzyme Specified by the Tryptophan Operon of Escherichia coli : Comparative Studies on the Complex and the Subunits (1969)

The properties of the anthranilate synthetase complex and its separated subunits were compared in catalyzing the anthranilate synthetase reaction, chorismate + l-glutamine or NH(4) (+) --> anthranilate, and the transferase reaction, anthranilate + 5'-phosphorylribosyl-1-pyrophosphate --> phosphoribosyl anthranilate. It is shown that anthranilate synthetase component I is activated by normal anthranilate synthetase component II, a component II(CRM) (CRM = immunologically cross-reacting material), and by a presumed fragment of component II produced by a deletion mutant. Significant differences between the complex and its subunits are demonstrated with respect to substrate affinity, thermostability, feedback inhibitor sensitivity, and activity in the presence of various divalent cations. Of particular interest are the findings that the transferase activity of component II is only inhibitable by l-tryptophan when the component is in the complex and that this inhibition does not appear to depend upon the feedback-sensitive site of component I.
Protein Therapy: In Vivo Protein Transduction by Polyarginine (11R) PTD and Subcellular Targeting Delivery (2003)

Protein Therapy is a newly developed method, which allows proteins, peptides and biologically active compounds to penetrate across the plasma membrane of eukaryotic cells by a polyarginine (most efficiently by 11-arginine, 11R) protein transduction domain. This method enables us to control the localization of targeted substances in subcellular compartments, such as the nuclei, mitochondria and post-synaptic density. The method is very efficient and applicable not only to cultured cells but also to tissue slices and the whole animal. Brain, heart, skeletal muscle, liver, pancreas and lymphocytes are efficient target organs and tissues for Protein Therapy. The method is therefore a very useful strategy in the post-genomic era. In this mini-review, the development of Protein Therapy and its application for cancer cells and neuroscience study will be shown.
How good are my data and what is the resolution? (2013)

Following integration of the observed diffraction spots, the process of `data reduction' initially aims to determine the point-group symmetry of the data and the likely space group. This can be performed with the program POINTLESS. The scaling program then puts all the measurements on a common scale, averages measurements of symmetry-related reflections (using the symmetry determined previously) and produces many statistics that provide the first important measures of data quality. A new scaling program, AIMLESS, implements scaling models similar to those in SCALA but adds some additional analyses. From the analyses, a number of decisions can be made about the quality of the data and whether some measurements should be discarded. The effective `resolution' of a data set is a difficult and possibly contentious question (particularly with referees of papers) and this is discussed in the light of tests comparing the data-processing statistics with trials of refinement against observed and simulated data, and automated model-building and comparison of maps calculated with different resolution limits. These trials show that adding weak high-resolution data beyond the commonly used limits may make some improvement and does no harm.
A Model for the Bulk Crushing Strength of Spherical Catalysts (1999)

Statistics and experiments reveal that the mechanical failure of a spherical catalyst under single-particle crushing strength and bulk crushing strength tests are both brittle fracture and the fact that the single particle strength data follow a Weibull distribution. A model is proposed for the packing of spherical particles, which assumes tetrahedral contact and force transmission between the spheres. A deduction from this packing is that the broken percentage of spheres during bulk strength measurement follows the relationship of the Weibull equation. Experimental results confirm this conclusion, which relates the single particle property and the bulk behavior of the packed bed of catalytic materials.
Type A Behaviour as a Determinant of Participation in Physical Activity and Sport Among Adolescents (1998)

As a part of an extensive research project 'Cardiovascular Risks in Young Finns ; this study examined the relationship between Type A behaviour and sports participation among adolescents. Subjects were 852 12- and 15-year-old boys and girls randomly selected from five Finnish university towns and their rural surroundings. Type A behaviour was categorized into two dimensions encompassing impatient- aggressive competitiveness (IAC) and responsible hard-driving (RHD). Level of participation in sport was measured by means of a short questionnaire. The results of the present study showed that active adolescents scored significantly higher on the RHD factor than passive adolescents in the four age-gender groups. Among boys, RHD increased with length of participation in competitive sport. Boys and girls participating in specifically competitive sports seemed to be a little more impatient and aggressive than those in non- competitive sports. The results of a 3-year follow-up study also showed that persistent participants and beginners (those who started training during the 3-year period) had a higher level of RHD than dropouts (those who ceased training during the 3-year period) and outsiders (those who did not participate at all), which may mean that organized sports tend to attract and retain participants who have certain psychological traits, rather than encouraging the development of those traits.
Uniform carbon-13 isotope labeling of proteins with sodium acetate for NMR studies: application to human carbonic anhydrase II (1991)

Uniform double labeling of proteins for NMR studies can be prohibitively expensive, even with an efficient expression and purification scheme, due largely to the high cost of [13C6, 99%]glucose. We demonstrate here that uniformly (greater than 95%) 13C and 15N double-labeled proteins can be prepared for NMR structure/function studies by growing cells in defined media containing sodium [1,2-13C2, 99%]acetate as the sole carbon source and [15N, 99%]ammonium chloride as the sole nitrogen source. In addition, we demonstrate that this labeling scheme can be extended to include uniform carbon isotope labeling to any desired level (below 50%) by utilizing media containing equal amounts of sodium [1-13C, 99%]acetate and sodium [2-13C, 99%]acetate in conjunction with unlabeled sodium acetate. This technique is less labor intensive and more straightforward than labeling using isotope-enriched algal hydrolysates. These labeling schemes have been used to successfully prepare NMR quantities of isotopically enriched human carbonic anhydrase II. The activity and the 1H NMR spectra of the protein labeled by this technique are the same as those obtained from the protein produced from media containing labeled glucose; however, the cost of the sodium [1,2-13C2, 99%]acetate growth media is considerably less than the cost of the [13C6, 99%]glucose growth media. We report here the first published 13C and 15N NMR spectra of human carbonic anhydrase II as an important step leading to the assignment of this 29-kDa zinc metalloenzyme.
A Case of Eosinophilic Gastroenteritis with Eosinophilic Ascites (2004)

Eosinophilic gastroenteritis is an uncommon disease characterized by the presence of abnormal gastrointestinal symptoms, eosinophilic infiltration in one or more areas of the gastrointestinal tract, an absence of the indentifiable cause of eosinophilia and the exclusion of eosinophilicinvolvement in organs other than gut. The etiology isunknown, and the pathogenesis is poorly understood.Clinical presentations depend on the region of gastrointestinaltract involved and the depth of bowel involvement. Weexperienced a case of eosinophilic gastroenteritis involving entire GI tract with eosinophilic ascites in a 72-year-old female with abdominal distention and pain. The patient wastreated with corticosteroid successfully. We report this case with a brief review of the literatures
α-lipoic Acid Mitigates Insulin Resistance in Goto-Kakizaki Rats (2004)

Impaired glucose uptake and metabolism by peripheral tissues is a common feature in both type I and type II diabetes mellitus. This phenomenon was examined in the context of oxidative stress and the early events within the insulin signalling pathway using soleus muscles derived from non-obese, insulin-resistant type II diabetic Goto-Kakizaki (GK) rats, a well-known genetic rat model for human type II diabetes. Insulin-stimulated glucose transport was impaired in soleus muscle from GK rats. Oxidative and non-oxidative glucose disposal pathways represented by glucose oxidation and glycogen synthesis in soleus muscles of GK rats appear to be resistant to the action of insulin when compared to their corresponding control values. These diabetes-related abnormalities in glucose disposal were associated with a marked diminution in the insulin-mediated enhancement of protein kinase B (Akt/PKB) and insulin receptor substrate-1 (IRS-1)-associated phosphatidylinostol 3-kinase (PI 3-kinase) activities; these two kinases are key elements in the insulin signalling pathway. Moreover, heightened state of oxidative stress, as indicated by protein bound carbonyl content, was evident in soleus muscle of GK diabetic rats. Chronic administration of the hydrophobic/hydrophilic antioxidant alpha -lipoic-acid (ALA, 100 mg/kg, i.p.) partly ameliorated the diabetes-related deficit in glucose metabolism, protein oxidation as well as the activation by insulin of the various steps of the insulin signalling pathway, including the enzymes Akt/PKB and PI-3 kinase. Overall, the current investigation illuminates the concept that oxidative stress may indeed be involved in the pathogenesis of certain types of insulin resistance. It also harmonizes with the notion of including potent antioxidants such as ALA in the armamentarium of antidiabetic therapy.
Complete nucleotide sequences of Marburg virus genes 5 and 6 encoding VP30 and VP24 proteins. (1995)

Nucleotide sequences of the genes 5 and 6 of the Marburg virus, Popp strain, were determined. ORFs encoding polypeptides VP30 (281 a.a., MW 32,640) and VP24 (253 a.a., MW 28,621) were found. The putative transcription start and stop signals for viral RNA-dependent RNA polymerase were revealed for both genes. Overlapping of genes 5 and 6 was shown. The deduced amino acid sequences of VP30 and VP24 proteins displayed significant homology with the analogous proteins of another filovirus, the Ebola virus (33% and 37%, respectively). The VP24 appeared to have a hydrophobic amino acid composition; content of hydrophobic amino acids was 40.7%. Model of VP24 location in the virion was suggested.
Structure of the human smooth muscle alpha-actin gene. Analysis of a cDNA and 5' upstream region. (1990)

The structures of a cDNA and the 5' upstream region of the human smooth muscle alpha-actin gene have been characterized. Transcriptional start sites and the non-coding first exon were mapped by primer extension analysis and by comparing cDNA and genomic sequences. The deduced human smooth muscle alpha-actin protein sequence is identical to the corresponding bovine protein sequence, and thus confirms that the previously determined human genomic sequence contained a mutation at codon 312. Human smooth muscle cells express only a single, 1.4-kilobase smooth muscle alpha-actin transcript. 5' Noncoding sequences that have the greatest similarity to the chicken gene are located in five noncontiguous segments, extending from approximately 250 base pairs upstream of the cap site through the first exon. Conserved sequences encompass a region required for expression and tissue-specific regulation of chicken smooth muscle alpha-actin and therefore are probably also important for expression of the human gene.
Automatic Pattern Generation System for Phase Shifting Mask (1991)

The phase shifting technology has excellent advantages for improving resolution and depth of focus in photolithography. In applying the phase shifting mask for the VLSI fabrication, the greatest difficulty lies in the generation of the phase shifting patterns. As no CAD tool has been available, the designer has to create the phase shifting patterns by full manual operation. It requires a huge effort to complete the operation.