gebhart/patrepeval huggingface dataset:
EFFECTS OF BRADYKININ ON [3H]‐NOREPINEPHRINE RELEASE IN RAT HYPOTHALAMUS (1993)

1. We examined the regulatory actions of bradykinin on norepinephrine release in the hypothalamus of rats. 2. Bradykinin increased the stimulation-evoked [3H]-norepinephrine release from hypothalamic slices of Sprague-Dawley rats in a dose-dependent manner (1 Hz: S2/S1 ratio, mean +/- s.e.m., control 0.868 +/- 0.016, n = 6; bradykinin 1 x 10(-6) mol/L 1.039 +/- 0.018, n = 6, P < 0.05; bradykinin 3.3 x 10(-6) mol/L 1.130 +/- 0.064, n = 6, P < 0.05). The basal release of [3H]-norepinephrine was not affected by the peptide. 3. Bay K 8644, a dihydropyridine-sensitive calcium channel agonist, significantly potentiated the facilitatory effect of bradykinin on norepinephrine release, although Bay K 8644 by itself had no significant effect. By contrast, nicardipine, a dihydropyridine-sensitive calcium channel blocker, reversed the increase in norepinephrine release induced by bradykinin and Bay K 8644. 4. These results indicate that bradykinin may increase norepinephrine release in rat hypothalamus, partially mediated by interactions with dihydropyridine-sensitive calcium channels.
Serum ferritin determination by enzyme immunoassay: importance of sample dilution (the "Hook effect") (1982)

Journal Article Serum ferritin determination by enzyme immunoassay: importance of sample dilution (the "Hook effect") Get access M C Revenant, M C Revenant Search for other works by this author on: Oxford Academic Google Scholar A Beaudonnet A Beaudonnet Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 28, Issue 1, 1 January 1982, Pages 253–254, https://doi.org/10.1093/clinchem/28.1.253 Published: 01 January 1982
An Analysis of Pulse Control for Simple Mechanical Systems (1985)

An efficient pulse control method for insuring safety of simple mechanical systems is developed and its sensitivity to the excitation frequency content and to various control parameters is studied. The control algorithm, consisting of applying pulse forces in a feedback fashion, is designed to insure that maximum system response is limited to safe values at all times. It is shown that the proposed algorithm is simple to implement and is efficient in controlling peak response in terms of on-line computation and pulse energy required. The technique is illustrated and analyzed for a single-degree-of-freedom linear system.
Chemistry, Biochemistry, and Safety of Acrylamide. A Review (2003)

Acrylamide (CH2=CH-CONH2), an industrially produced alpha,beta-unsaturated (conjugated) reactive molecule, is used worldwide to synthesize polyacrylamide. Polyacrylamide has found numerous applications as a soil conditioner, in wastewater treatment, in the cosmetic, paper, and textile industries, and in the laboratory as a solid support for the separation of proteins by electrophoresis. Because of the potential of exposure to acrylamide, effects of acrylamide in cells, tissues, animals, and humans have been extensively studied. Reports that acrylamide is present in foods formed during their processing under conditions that also induce the formation of Maillard browning products heightened interest in the chemistry, biochemistry, and safety of this vinyl compound. Because exposure of humans to acrylamide can come from both external sources and the diet, a need exists to develop a better understanding of its formation and distribution in food and its role in human health. To contribute to this effort, this integrated review presents data on the chemistry, analysis, metabolism, pharmacology, and toxicology of acrylamide. Specifically covered are the following aspects: nonfood and food sources; exposure from the environment and the diet; mechanism of formation in food from asparagine and glucose; asparagine-asparaginase relationships; Maillard browning-acrylamide relationships; quenching of protein fluorescence; biological alkylation of amino acids, peptides, proteins, and DNA by acrylamide and its epoxide metabolite glycidamide; risk assessment; neurotoxicity, reproductive toxicity, and carcinogenicity; protection against adverse effects; and possible approaches to reducing levels in food. Further research needs in each of these areas are suggested. Neurotoxicity appears to be the only documented effect of acrylamide in human epidemiological studies; reproductive toxicity, genotoxicity/clastogenicity, and carcinogenicity are potential human health risks on the basis of only animal studies. A better understanding of the chemistry and biology of pure acrylamide in general and its impact in a food matrix in particular can lead to the development of improved food processes to decrease the acrylamide content of the diet.
Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4 (1997)

Bicyclams are a novel class of antiviral compounds that are highly potent and selective inhibitors of the replication of HIV-1 and HIV-2. Surprisingly, however, when the prototype compound AMD3100 was tested against M-tropic virus strains such as BaL, ADA, JR-CSF, and SF-162 in human peripheral blood mononuclear cells, the compound was completely inactive. Because of the specific and potent inhibitory effect of AMD3100 on T-tropic viruses, but not M-tropic viruses, it was verified that AMD3100 interacts with the CXC-chemokine receptor CXCR4, the main coreceptor used by T-tropic viruses. AMD3100 dose dependently inhibited the binding of a specific CXCR4 monoclonal antibody to SUP-T1 cells as measured by flow cytometry. It did not inhibit the binding of the biotinylated CC-chemokine macrophage inflammatory protein (MIP) 1alpha or MIP-1beta, ligands for the chemokine receptor CCR5 (the main coreceptor for M-tropic viruses). In addition, AMD3100 completely blocked (a) the Ca2+ flux at 100 ng/ml in lymphocytic SUP-T1 and monocytic THP-1 cells, and (b) the chemotactic responses of THP-1 cells induced by stromal cell-derived factor 1alpha, the natural ligand for CXCR4. Finally, AMD3100 had no effect on the Ca2+ flux induced by the CC-chemokines MIP-1alpha, regulated on activation normal T cell expressed and secreted (RANTES; also a ligand for CCR5), or monocyte chemoattractant protein 3 (a ligand for CCR1 and CCR2b), nor was it able to induce Ca2+ fluxes by itself. The bicyclams are, to our knowledge, the first low molecular weight anti-HIV agents shown to act as potent and selective CXCR4 antagonists.
Identification of a gp41 Core-Binding Molecule with Homologous Sequence of Human TNNI3K-Like Protein as a Novel Human Immunodeficiency Virus Type 1 Entry Inhibitor (2010)

Human immunodeficiency virus type 1 (HIV-1) gp41 plays a critical role in the viral fusion process, and its N- and C-terminal heptad repeat domains serve as important targets for developing anti-HIV-1 drugs, like T-20 (generic name, enfuvirtide; brand name, Fuzeon). Here, we conducted a yeast two-hybrid screening on a human bone marrow cDNA library using the recombinant soluble gp41 ectodomain as the bait and identified a novel gp41 core-binding molecule, designated P20. P20 showed no homology with a current HIV fusion inhibitor, T-20, but had sequence homology to a human protein, troponin I type 3 interacting kinase (TNNI3K)-like protein. While it could bind to the six-helix bundle core structure formed by the N- and C-terminal heptad repeats, P20 did not interrupt the formation of the six-helix bundle. P20 was effective in blocking HIV-1 Env-mediated syncytium formation and inhibiting infection by a broad spectrum of HIV-1 strains with distinct subtypes and coreceptor tropism, while it was ineffective against other enveloped viruses, such as vesicular stomatitis virus and influenza A virus. P20 exhibited no significant cytotoxicity to the CD4(+) cells that were used for testing antiviral activity. Among the 11 P20 mutants, four analogous peptides with a common motif (WGRLEGRRT) exhibited significantly reduced anti-HIV-1 activity, suggesting that this region is the critical active site of P20. Therefore, this peptide can be used as a lead for developing novel HIV fusion inhibitors and as a probe for studying the membrane-fusogenic mechanism of HIV.
Comparative, Quantitative Study of Lymphoid and Non-Lymphoid Uptake of 60 nm Polystyrene Particles (1994)

Uptake by gut epithelial tissue of 60 nm polystyrene particles was studied in female Sprague-Dawley rats (180 g, 9 weeks old) after 5 days oral dosing by gavage (14 mg/kg). The gut was divided into lymphoid and non-lymphoid tissue of the small and large intestine, prior to analysis for polystyrene by gel permeation chromatography (GPC). Approximately 10% of the administered dose was recovered from the entire gastrointestinal tract. The total percentage of the administered dose taken up through lymphoid tissue was statistically much greater than through non-lymphoid tissue. It was estimated that 60% of the uptake in the small intestine occurred through the Peyer's patches, even though the patches comprised a small percentage of the total surface area of the small intestinal tissue. A significant amount of the total uptake was shown to occur in the large intestine, particularly in the lymphoid sections of this tissue. These results were confirmed by fluorescence microscopy.
Paclitaxel Nano-Delivery Systems: A Comprehensive Review (2013)

Paclitaxel is one of the most effective chemotherapeutic drugs ever developed and is active against a broad range of cancers, such as lung, ovarian, and breast cancers. Due to its low water solubility, paclitaxel is formulated in a mixture of Cremophor EL and dehydrated ethanol (50:50, v/v) a combination known as Taxol. However, Taxol has some severe side effects related to Cremophor EL and ethanol. Therefore, there is an urgent need for the development of alternative Taxol formulations. The encapsulation of paclitaxel in biodegradable and non-toxic nano-delivery systems can protect the drug from degradation during circulation and in-turn protect the body from toxic side effects of the drug thereby lowering its toxicity, increasing its circulation half-life, exhibiting improved pharmacokinetic profiles, and demonstrating better patient compliance. Also, nanoparticle-based delivery systems can take advantage of the enhanced permeability and retention (EPR) effect for passive tumor targeting, therefore, they are promising carriers to improve the therapeutic index and decrease the side effects of paclitaxel. To date, paclitaxel albumin-bound nanoparticles (Abraxane®) have been approved by the FDA for the treatment of metastatic breast cancer and non-small cell lung cancer (NSCLC). In addition, there are a number of novel paclitaxel nanoparticle formulations in clinical trials. In this comprehensive review, several types of developed paclitaxel nano-delivery systems will be covered and discussed, such as polymeric nanoparticles, lipid-based formulations, polymer conjugates, inorganic nanoparticles, carbon nanotubes, nanocrystals, and cyclodextrin nanoparticles.
Algorithm for the detection of fine clustered calcifications on film mammograms. (1988)

An algorithmic process for the detection and marking of clustered calcifications in digitized film-screen mammograms has been applied to mammograms from 50 clinical cases sampled at two digitization levels, in both the craniocaudal and mediolateral views. In all but one case the detector accurately located suggestive clusters found by radiologists in normal screening. In five cases additional clusters were also found by the detector. The detector has a negligible false-positive rate for the detection of clustered calcifications, although it is sensitive to clusters of emulsion defects displayed as artifactual calcification densities in the original film. The detector is flexible in structure and is easily adapted to various calcification/cluster criteria. The detector shows considerable promise when applied to clinical examples but will require refinement before formal testing.
An overview of free viewpoint depth-image-based rendering (DIBR) (2010)

3D Video has caught enormous attention in consumer market due to the progress in technical maturity of 3D displays, digital video broadcasts and computer vision algorithms. Video-plus-depth representation makes the concept of free viewpoint video feasible allowing the user to freely navigate within real world visual scenes. In this paper, we review the existing methodologies and 3D video processing framework. Previous image-based rendering techniques can be classified into three categories according to the amount of geometric information being used, of which DIBR combines the advantages of the two extremes (geometry based and image based representations). We then discuss the techniques for depth map creation, the method for rendering given the depth information and post-processing for corresponding artifacts in the multi-view adaptation. We also issue the quality measurement of the generated depth and synthesized view. In respect to the clear demand from industry and user side for such new types of visual media, there is still a large improving room in the 3D data representation and rendering quality of 3D perception.
TET proteins and the control of cytosine demethylation in cancer (2015)

The discovery that ten-eleven translocation (TET) proteins are α-ketoglutarate-dependent dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine and 5-carboxycytosine has revealed new pathways in the cytosine methylation and demethylation process. The description of inactivating mutations in TET2 suggests that cellular transformation is in part caused by the deregulation of this 5-mC conversion. The direct and indirect deregulation of methylation control through mutations in DNA methyltransferase and isocitrate dehydrogenase (IDH) genes, respectively, along with the importance of cytosine methylation in the control of normal and malignant cellular differentiation have provided a conceptual framework for understanding the early steps in cancer development. Here, we review recent advances in our understanding of the cytosine methylation cycle and its implication in cellular transformation, with an emphasis on TET enzymes and 5-hmC. Ongoing clinical trials targeting the activity of mutated IDH enzymes provide a proof of principle that DNA methylation is targetable, and will trigger further therapeutic applications aimed at controlling both early and late stages of cancer development.
Sensitivity of parallel applications to large differences in bandwidth and latency in two-layer interconnects (1999)

This paper studies application performance on systems with strongly non-uniform remote memory access. In current generation NUMAs the speed difference between the slowest and fastest link in an interconnect-the "NUMA gap"-is typically less than an order of magnitude, and many conventional parallel programs achieve good performance. We study how different NUMA gaps influence application performance, up to and including typical wide-area latencies and bandwidths. We find that for gaps larger than those of current generation NUMAs, performance suffers considerably (for applications that were designed for a uniform access interconnect). For many applications, however, performance can be greatly improved with comparatively simple changes: traffic over slow links can be reduced by making communication patterns hierarchical-like the interconnect. We find that in four out of our six applications the size of the gap can be increased by an order of magnitude or more without severely impacting speedup. We analyze why the improvements are needed, why they work so well, and how much non-uniformity they can mask.
Enhanced dead-end elimination in the search for the global minimum energy conformation of a collection of protein side chains (1995)

Although the conformational states of protein side chains can be described using a library of rotamers, the determination of the global minimum energy conformation (GMEC) of a large collection of side chains, given fixed backbone coordinates, represents a challenging combinatorial problem with important applications in the field of homology modelling. Recently, we have developed a theoretical framework, called the dead-end elimination method, which allows us to identify efficiently rotamers that cannot be members of the GMEC. Such dead-ending rotamers can be iteratively removed from the system under study thereby tracking down the size of the combinatorial problem. Here we present new developments to the dead-end elimination method that allow us to handle larger proteins and more extensive rotamer libraries. These developments encompass (i) a procedure to determine weight factors in the generalized dead-end elimination theorem thereby enhancing the elimination of dead-ending rotamers and (ii) a novel strategy, mainly based on logical arguments derived from the logic pairs theorem, to use dead-ending rotamer pairs in the efficient elimination of single rotamers. These developments are illustrated for proteins of various sizes and the flow of the current method is discussed in detail. The effectiveness of dead-end elimination is increased by two orders of magnitude as compared with previous work. In addition, it now becomes feasible to use extremely detailed libraries. We also provide an appendix in which the validity of the generalized dead-end criterion is shown. Finally, perspectives for further applications which may now become within reach are discussed.
Randomized, controlled comparison of two forms of preparation for screening flexible sigmoidoscopy. (1997)

Patient acceptance, encounter time, technical ease, and quality of colon preparation were significantly better with the oral form of colon preparation than with the standard Fleet enema preparation.
Tunable chromatic dispersion compensator utilizing silica waveguide ring resonator having Mach-Zehnder interferometric variable coupler eliminating crossing point of waveguides (2003)

A new configuration for an all-pass filter-based tunable chromatic dispersion compensator utilizing silica waveguide ring resonators having a Mach-Zehnder interferometer without a crossing point was proposed and fabricated. FSR of 24 GHz and tuning range of +/-1280 ps/nm was confirmed.
Growth of Conductive Indium Tin Oxide (ITO) Nanoparticles by Mineralization in Ring-Shaped Biomimetic Templates (2009)

Indium tin oxide (ITO) nanoparticles were synthesized by mineralization in the cavity of ring-shaped templates that were generated by the self-assembly of peptide-based biomimetic molecules. The ITO nanoparticles grew to an average diameter of 150 nm. This exclusive ITO nanoparticle growth was driven by the catalytic property of the biomimetic template, and growth was only observed when the biomimetic template was present in the reaction mixture. Due to the interaction of the biomimetic template with the indium ion, the crystalline structure of the ITO nanoparticles was transformed to a fluorite (CaF2) structure, in contrast to the hexagonal structure of those prepared by coprecipitation. In addition, the synthesized ITO nanoparticles showed a lowered bias voltage compared to those prepared without the peptide-derivative assembly. These findings indicate that mineralization using a biomimetic template is a promising method to produce functional nanomaterials at room temperature, allowing for control of the shape, crystalline structure, and physical properties of the nanoparticles.
Comparison of NMR solution structures of the receptor binding domains of Pseudomonas aeruginosa pili strains PAO, KB7, and PAK: implications for receptor binding and synthetic vaccine design (1995)

The solution structures of peptide antigens from the receptor binding domains of Pseudomonas aeruginosa strains PAO and KB7 have been determined using two-dimensional 1H NMR techniques. Ensembles of solution conformations for the trans forms of these 17-residue disulfide-bridged peptides have been generated using a simulated annealing procedure in conjunction with distance and torsion angle restraints derived from NMR data. Comparison of the NMR-derived solution structures of the PAO and KB7 peptides, with that previously determined (McInnes et al., 1993) and herein refined for the PAK peptide reveals a common structural motif. All three peptide structures contain a type I beta-turn in the conserved sequence Asp134-X-X-Phe137 and a type II beta-turn in the conserved sequence Pro139-X-Gly-Cys142. However, the overall folds of the three peptides differ as well as the disposition of the side chains comprising the hydrophobic pockets. The similarities and differences between the structures of the three strains which bind to a common cell surface receptor are discussed in light of their contributions to synthetic vaccine design.
Polygon-assisted JPEG and MPEG compression of synthetic images (1995)

Recent advances in realtime image compression and decompression hardware make it possible for a high-performance graphics engine to operate as a rendering server in a networked environment. If the client is a low-end workstation or set-top box, then the rendering task can be split across the two devices. In this paper, we explore one strategy for doing this. For each frame, the server generates a high-quality rendering and a low-quality rendering, subtracts the two, and sends the difference in compressed form. The client generates a matching low quality rendering, adds the decompressed difference image, and displays the composite. Within this paradigm, there is wide latitude to choose what constitutes a high-quality versus low-quality rendering. We have experimented with textured versus untextured surfaces, fine versus coarse tessellation of curved surfaces, Phong versus Gouraud interpolated shading, and antialiased versus nonantialiased edges. In all cases, our polygon-assisted compression looks subjectively better for a fixed network bandwidth than compressing and sending the high-quality rendering. We describe a software simulation that uses JPEG and MPEG-1 compression, and we show results for a variety of scenes.
Split-gate field-effect transistor (1989)

We propose a new field-effect transistor (FET) where the gate voltage swing (i.e., the difference between the gate voltage and the threshold voltage) is varied along the channel in such a way that charge carriers are accelerated more rapidly and the average carrier velocity in the channel is increased. This can be achieved either by making the threshold voltage to be a function of position or by using a new device structure—split-gate FET (SFET). In both cases a smaller gate voltage swing close to the source leads to a higher electric field in this portion of the channel and, hence, to a more rapid increase of the carrier drift velocity with distance. Calculations of the device transconductances for a heterostructure SFET using a charge-control model show that the performance in the split-gate device is considerably improved compared to a conventional device. The improved electric field and potential distributions in a SFET should make it possible to utilize ballistic effects in this lateral device.
Angiogenesis: A Marker for Neoplastic Transformation of Mammary Papillary Hyperplasia (1977)

Mouse mammary papillomas elicit new formation of vessels when transplanted onto the rabbit iris. This angiogenic capacity is a property of carcinomas but not of the resting mammary gland. In mouse papillary hyperplasias, however, this property appears much earlier than any morphological or clinical sign of carcinoma. A test for angiogenic capacity may reveal a step in the progression toward clinical malignancy and thus could be used to screen for neoplastic potential of hyperplastic epithelium in biopsy tissues.