gebhart/patrepeval huggingface dataset:
Acylphosphonates: phosphorus-carbon bond cleavage of dialkyl acylphosphonates by means of amines. Substituent and solvent effects for acylation of amines (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcylphosphonates: phosphorus-carbon bond cleavage of dialkyl acylphosphonates by means of amines. Substituent and solvent effects for acylation of aminesMitsuo Sekine, Masaki Satoh, Hikaru Yamagata, and Tsujiaki HataCite this: J. Org. Chem. 1980, 45, 21, 4162–4167Publication Date (Print):October 1, 1980Publication History Published online1 May 2002Published inissue 1 October 1980https://pubs.acs.org/doi/10.1021/jo01309a019https://doi.org/10.1021/jo01309a019research-articleACS PublicationsRequest reuse permissionsArticle Views1151Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Secure Access Code Technique for Remote Data Integrity on Public Cloud (2013)

The present business trend highly demands more sophisticated techniques for remote data storage to stay alive in the competition among the business holders. The situation is more critical when the data to be stored is confidential information such as business policies, business rules and statistical data about the organization that is often needed to be shared with in the trusted enclave. Inevitably this scenario forces the need for the remote data integrity on mistrusted public cloud where the integrity of the data is not only being checked by the owner of the file but also by the people in the trusted enclave. This paper addresses new solution for remote data integrity using access code by implementing data level dynamics without the need for third party auditors.
Functional Food Targeting the Regulation of Obesity-Induced Inflammatory Responses and Pathologies (2010)

Obesity is associated with a low-grade systemic chronic inflammatory state, characterized by the abnormal production of pro- and anti-inflammatory adipocytokines. It has been found that immune cells such as macrophages can infiltrate adipose tissue and are responsible for the majority of inflammatory cytokine production. Obesity-induced inflammation is considered a potential mechanism linking obesity to its related pathologies, such as insulin resistance, cardiovascular diseases, type-2 diabetes, and some immune disorders. Therefore, targeting obesity-related inflammatory components may be a useful strategy to prevent or ameliorate the development of such obesity-related diseases. It has been shown that several food components can modulate inflammatory responses in adipose tissue via various mechanisms, some of which are dependent on peroxisome proliferator-activated receptor gamma (PPARgamma), whereas others are independent on PPARgamma, by attenuating signals of nuclear factor-kappaB (NF-kappaB) and/or c-Jun amino-terminal kinase (JNK). In this review, we introduce the beneficial effects of anti-inflammatory phytochemicals that can help prevent obesity-induced inflammatory responses and pathologies.
Preservation and detection of specific antibody—peptide complexes by matrix-assisted laser desorption ionization mass spectrometry (2000)

The direct detection of an antibody-peptide complex is reported by matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS). Experimental conditions have been found in which specific, noncovalent interactions in solution are maintained throughout the sample preparation and ionization process. Mass measurements based on the ion signals for the intact antibody and 1:1 antibody-peptide complex reveal that specific noncovalent associations between a monoclonal antibody and a peptide, which comprises the determinant of the corresponding antigen, are maintained in the gas phase. These results support the wider application of MALDI-MS to studies of the structure and specificity of macromolecular complexes important to immune and other biological function.
A New GaAs Field Effect Transistor (FET) with DIpole Barrier (DIB) (1994)

A new GaAs field effect transistor (FET) with dipole-barrier (DIBFET) employing a delta- n (δ n ) layer and a delta- p (δ p ) layer is proposed and fabricated. Electrons are confined in the upper undoped-GaAs layer (the channel layer) rather than around the δ n layer by the influence of the transverse electric field resulting from the dipole-barrier formation. This leads to the high electron concentration of 1.5×10 18 cm -3 with the electron drift mobility of 3600 cm 2 /V·s in the undoped GaAs channel at room temperature. The fabricated GaAs DIBFET with 0.8 µm gate length shows the maximum value of extrinsic transconductance of 366 mS/mm. The drain current density is larger than 800 mA/mm. The current gain cutoff frequency f T of 16.7 GHz and the maximum oscillation frequency f max of 67 GHz are obtained. One-dimensional calculation of device characteristics is performed for the purpose of evaluating the device performance.
Effects of low‐dose intranasal (S)‐ketamine in patients with neuropathic pain (2009)

Intranasal administration of low dose (S)-ketamine rapidly induces adequate plasma concentrations of (S)-ketamine and subsequently of its metabolite (S)-norketamine. The time course of analgesia correlated with plasma concentrations.
Lymphocyte Survival--Ignorance Is BLys (2000)

As if the TNF receptor and ligand superfamily was not big enough, two new receptors and their ligands have now been added to it. As Laâbi and Strasser explain in their Perspective, the receptors BCMA and TACI and their ligands BAFF/BLys and APRIL, respectively, are important for B lymphocyte survival, proliferation, and differentiation.
Endoscopic Study for the Pterygopalatine Fossa Anatomy (2009)

Endoscopic PPF surgery via the middle nasal meatus-sphenopalatine foramen approach is safe, and the ethmoidal crest, sphenopalatine foramen, and Y structure with the pterygopalatine ganglion in the center are important anatomic landmarks that can be referred to during the surgery.
The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors (1999)

DNA methylation in mammals is required for embryonic development, X chromosome inactivation and imprinting. Previous studies have shown that methylation patterns become abnormal in malignant cells and may contribute to tumorigenesis by improper de novo methylation and silencing of the promoters for growth-regulatory genes. RNA and protein levels of the DNA methyltransferase DNMT1 have been shown to be elevated in tumors, however murine stem cells lacking Dnmt1 are still able to de novo methylate viral DNA. The recent cloning of a new family of DNA methyltransferases (Dnmt3a and Dnmt3b) in mouse which methylate hemimethylated and unmethylated templates with equal efficiencies make them candidates for the long sought de novo methyltransferases. We have investigated the expression of human DNMT1, 3a and 3b and found widespread, coordinate expression of all three transcripts in most normal tissues. Chromosomal mapping placed DNMT3a on chromosome 2p23 and DNMT3b on chromosome 20q11.2. Significant overexpression of DNMT3b was seen in tumors while DNMT1 and DNMT3a were only modestly over-expressed and with lower frequency. Lastly, several novel alternatively spliced forms of DNMT3b, which may have altered enzymatic activity, were found to be expressed in a tissue-specific manner.
Catalytic Dealkylation of Phosphates with Binuclear Boron Compounds (2002)

The Salen(tBu) ligand and its derivatives were used to prepare binuclear boron complexes. These compounds have the formula, L(BBr2)2 (L = Salpen(tBu) and Salben(tBu)). These are formed from the reaction of the corresponding L[B(OMe)2]2 with BBr3. They represent a new type of binuclear boron compound. These compounds are active towards the dealkylation of many phosphates. They are also catalytically active with a stoichiometric amount of BBr3 to trimethylphosphate.
5-Alkynyl Pyrimidine Nucleosides as Potent Selective Inhibitors of Varicella-Zoster Virus (1992)

A series of 5-alkynyl substituted 2′-deoxyuridine and β-D-arabinofuranosyluracil nucleosides were synthesized and evaluated for in vitro activity against varicella-zoster virus (VZV). Three promising analogues, 1-(β-D-arabinofuranosyl)-5-ethynyluracil (EYaraU), 2′-deoxy-5-prop-1-ynyluridine (PYdU) and 1-(β-D-arabinof uranosyl)-5-prop-1-ynyluracil (PYaraU) had potent activity against eight strains of VZV with IC 50 values averaging 1 μM. This activity was selective for VZV as the compounds were significantly less active against herpes simplex viruses (HSV) and human cytomegalovirus (HCMV) in contrast to 2′-deoxy-5-ethynyluridine (EYdU) which is highly active against all three viruses. The ability of these compounds to inhibit the growth of Vera or MRC-5 cells was over 2 orders of magnitude less than their antiviral activity (CC 50 in Vero cells 350 μM for EYaraU and &gt;500 μM for PYdU and PYaraU and &gt;500 μM for all 3 compounds in MRC-5 cells). Direct comparative studies showed these compounds to be more potent and more selective than acyclovir (ACV).
cAMP-dependent inhibition is dominant in regulating superoxide production in the bone-resorbing osteoclasts (1998)

Calciotropic hormones such as parathyroid hormone (PTH) and calcitonin have been shown to have stimulatory and inhibitory effects respectively on superoxide anion (O2-) generation by osteoclasts, but the exact intracellular signalling mediating these pathways has not been investigated. In order to elucidate the intracellular pathways controlling O2- generation, we have carried out a systematic study of the effect of different agents on O2- production in osteoclasts cultured on bovine cortical bone. Dibutyryl cAMP and cholera toxin, while having no effect on the basal level of O2- production in bone-resorbing osteoclasts, were, however, found to completely block the stimulation of free radical production by PTH, pertussis toxin and ionomycin. The stimulation of O2- production was found to be independent of protein kinase C-dependent pathways since the presence of bisindolylmaleimide (GF109203X) (1 microM) did not block stimulation by PTH and pertussis toxin. Interestingly, while exposure to bisindolylmaleimide at this concentration did not have any effect on the basal level of O2- production, exposure to a higher concentration (10 microM), which is known to inhibit both protein kinase C and A, produced significant stimulation. These in vitro findings suggest that in the bone-resorbing cells, cAMP-dependent protein kinases prevent further stimulation of NADPH oxidase by agents such as PTH and pertussis toxin. The increase in cAMP has also been recently demonstrated to be associated with down-regulation of the oxidative burst in adherent neutrophils; and the findings reported here suggest a similar role for cAMP in O2- generation in osteoclasts cultured on bone.
Visualization of Single RNA Transcripts in Situ (1998)

Fluorescence in situ hybridization (FISH) and digital imaging microscopy were modified to allow detection of single RNA molecules. Oligodeoxynucleotide probes were synthesized with five fluorochromes per molecule, and the light emitted by a single probe was calibrated. Points of light in exhaustively deconvolved images of hybridized cells gave fluorescent intensities and distances between probes consistent with single messenger RNA molecules. Analysis of beta-actin transcription sites after serum induction revealed synchronous and cyclical transcription from single genes. The rates of transcription initiation and termination and messenger RNA processing could be determined by positioning probes along the transcription unit. This approach extends the power of FISH to yield quantitative molecular information on a single cell.
Characterization and use of the potent ribonuclease inhibitor aurintricarboxylic acid for the isolation of RNA from animal tissues (1989)

Inclusion of aurintricarboxylic acid (ATA) in extraction buffers for the isolation of RNA from animal tissues resulted in high yields (0.5-2.0 mg/g of tissue) of undegraded material as judged by agarose-gel-electrophoretic analyses and Northern-blotting experiments. However, ATA bound to nucleic acids, forming stable complexes, and so we have established methods for spectrophotometric quantification of RNA in these coloured complexes, and for easy removal of sufficient ATA to leave RNA in a consistently hybridizable condition at the end of a purification. The use and subsequent removal of ATA was straightforward and gave satisfactory results for all rat tissues tested.
Targeting the proteasome pathway (2009)

The proteasome and other members in the ubiquitin-proteasome pathway have emerged as novel therapeutic targets.
Accurate pose and location estimation of uncalibrated camera in urban area (2009)

This paper proposes an improved calibration method based on multi-view's vanishing point to estimate the accurate pose and location parameters of camera in building scene. This method put the lens distortion and orientation parameters of camera directly into the calibration mode. Furthermore, using the line feature existing in the building surface, geometric constraints are introduced into the calibrating model. The orientation parameters of camera can be estimated accurately by this method.
Formation of Quinol Ethers using (Diacetoxyiodo)benzene (1987)

The use of (diacetoxyiodo)benzene [diacetoxy(phenyl)iodine] for the oxidative coupling of a hindered phenol with aliphatic alcohols or other phenols has been investigated.
Anti‐high mobility group box‐1 monoclonal antibody treatment of brain edema induced by influenza infection and lipopolysaccharide (2018)

Encephalopathy is a major cause of influenza-associated child death and severe neurological sequelae in Japan, highlighting the urgent need for new therapeutic strategies. In this study, we evaluated the effects of anti-high mobility group box-1 monoclonal antibody (α-HMGB1) treatment on brain edema induced by influenza A virus (IAV) and lipopolysaccharide in 4-week-old BALB/c female mice. The results showed that administration of 7.5 mg/kg α-HMGB1 1 h after IAV (A/Puerto Rico/8/34) inoculation significantly alleviated brain edema at 48 h after IAV inoculation, as confirmed by the suppression of Evans Blue dye leakage and matrix metallopeptidase-9 mRNA expression in the brain. Moreover, we also observed suppression of oxidative stress and different cytokines in IAV-inoculated mice. The expression of plasminogen activator inhibitor-1 was also attenuated following treatment with α-HMGB1. Notably, α-HMGB1 treatment had no effect on virus propagation in the lung. In summary, anti-HMGB1 treatment may improve the prognosis in cases with influenza-associated encephalopathy by attenuating brain edema and reducing the inflammatory responses induced by HMGB1.
The Nervous System (2017)

During the 1860s, a cult of sensation took full hold of cultures across much of Western Europe and North America; as the term “sensation” implies, this craze was linked to developments in neurology. This chapter focuses on one particular network in the construction of the modern neural subject, a network that connects elements as seemingly diverse as railway trains, changing notions of risk and trauma, and the newly popular form of melodrama dubbed “sensation drama,” with the emblematic scenario of the person tied to the train tracks and rescued in the nick of time. This “railway rescue” scenario emerged in the late 1860s, spread like wildfire, and continued in our collective consciousness to the present. This chapter traces the explosive rise and iconic significance of this scenario, and concludes by reading a Dickens short story that reflects on melodrama and the ghostly traumas of industrialized sensation.
Clinical Trials in Psychiatry: Do Results Apply to Practice? (2001)

Recommendations for researchers include more complete assessments of factors that account for individual difference, an appraisal of outcomes more important to patients than symptom scores, and the use of statistical methods that permit the evaluation of individual difference. Recommendations for clinicians include a careful differentiation of results obtained in different phases of clinical trials and a clear appreciation of the different purposes of those trials. Clinicians should also appreciate that short-term effectiveness is not the same as long-term outcome and that aggregate scores may not apply to individual patients.
Amino-terminal Truncation of Chemokines by CD26/Dipeptidyl-peptidase IV (1998)

Chemokines are key players in inflammation and infection. Natural forms of the C-X-C chemokine granulocyte chemotactic protein-2 (GCP-2) and the C-C chemokine regulated on activation normal T cell expressed and secreted (RANTES), which miss two NH2-terminal residues, including a Pro in the penultimate position, have been isolated from leukocytes or tumor cells. In chemotaxis and intracellular calcium mobilization assays, the truncation caused a reduction in the specific activity of RANTES but not of GCP-2. The serine protease CD26/dipeptidyl-peptidase IV (CD26/DPP IV) could induce this observed NH2-terminal truncation of GCP-2 and RANTES but not that of the monocyte chemotactic proteins MCP-1, MCP-2 and MCP-3. No significant difference in neutrophil activation was detected between intact and CD26/DPP IV-truncated GCP-2. In contrast to intact natural RANTES(1-68), which still chemoattracts monocytes at 10 ng/ml, CD26/DPP IV-truncated RANTES(3-68) was inactive at 300 ng/ml and behaved as a natural chemotaxis inhibitor. Compared with intact RANTES, only a 10-fold higher concentration of RANTES(3-68) induced a significant Ca2+ response. Furthermore, RANTES(3-68) inhibited infection of mononuclear cells by an M-tropic HIV-1 strain 5-fold more efficiently than intact RANTES. Thus, proteolytic processing of RANTES by CD26/DPP IV may constitute an important regulatory mechanism during anti-inflammatory and antiviral responses.
NADPH oxidase and endothelial cell function (2005)

Intracellular ROS (reactive oxygen species) such as superoxide and H2O2 have been increasingly appreciated to have a role in endothelial pathophysiology. Of the several sources within the vasculature, a family of multi-subunit NADPH oxidases appears to be a predominant contributor of endothelial superoxide. More importantly, this enzyme system is activated by numerous stimuli and is involved in triggering diverse intracellular signalling pathways ('redox-sensitive' signalling pathways) that have a central role in conditions such as endothelial activation and inflammation, cell growth, apoptosis and hypertrophy. Furthermore, NADPH oxidase-derived superoxide contributes to the impairment of endothelium-dependent vasodilatation by inactivating nitric oxide; the resultant endothelial dysfunction is implicated in the pathophysiology of diseases such as atherosclerosis, hypertension, diabetic vasculopathy and heart failure. A detailed understanding of the regulation of NADPH oxidases and their modulation and downstream effects may define novel therapeutic targets for cardiovascular disease prevention and treatment in the clinical setting, in contrast with global antioxidant therapy which has to date been disappointing.
Identification of the region including the epitope for a monoclonal antibody which can neutralize human parvovirus B19 (1991)

In this study, we identified a region in the human parvovirus structural protein which involves the neutralization of the virus by a monoclonal antibody and site-specific synthetic peptides. A newly established monoclonal antibody reacted with both viral capsid proteins VP1 and VP2. The epitope was found in six strains of independently isolated human parvovirus B19. The monoclonal antibody could protect colony-forming unit erythroid in human bone marrow cell culture from injury by the virus. The monoclonal antibody reacted with only 1 of 12 peptides that were synthesized according to a predicted amino acid sequence based on nucleotide sequences of the coding region for the structural protein of B19 virus. The sequence recognized by the antibody was a site corresponding to amino acids 328 to 344 from the amino-terminal portion of VP2. This evidence suggests that the epitope of the viral capsid protein is located on the surface of the virus and may be recognized by virus-neutralizing antibodies.
Crystal structure of tissue factor in complex with antibody 10H10 reveals the signaling epitope (2017)

Tissue factor (TF) initiates the extrinsic pathway of blood coagulation through sequential binding and activation of coagulation factors VII (FVII) and X (FX). In addition, through activation of G-protein-coupled protease activated receptors (PARs) TF induces cell signaling that is related to cancer, angiogenesis and inflammation. Monoclonal antibodies (mAbs) proved to be a useful tool for studying the interplay between TF signaling and coagulation. MAb 10H10 is unique in that it blocks the signaling pathway and thus inhibits angiogenesis and tumor growth without interfering with coagulation. It was also presumed that mAb 10H10 recognizes the cryptic pool of TF devoid of procoagulant activity. The crystal structure of the 10H10 Fab was determined in the absence and in the presence of the TF extracellular domain (ECD). The structures show that the antibody operates by the key-and-lock mechanism causing no conformational changes in either Fab or TF. The TF:10H10 interface is extensive and includes five segments of TF in both the N-terminal and C-terminal domains of the ECD. Neither the known epitope of FVII, nor the putative epitope of FX overlaps with the 10H10 binding site. The 10H10 epitope points to the likely location of the PAR2 exosite. It is also the hypothetical site of TF interaction with integrins that may play a major role in the encryption-decryption process.