gebhart/patrepeval huggingface dataset:
A hybrid digital/RF envelope predistortion linearization system for power amplifiers (2005)

This paper presents an adaptive wide-band digitally controlled RF envelope predistortion linearization system for power amplifiers (PAs). A field-programmable gate-array-based lookup table is indexed by a digitized envelope power signal, and instantaneously adjusts the input signal amplitude and phase via an RF vector modulator to compensate for the AM-AM and AM-PM distortion. The advantages of this predistortion architecture over conventional baseband digital approaches are that a 20%-33% wider correction bandwidth is achievable at the same clock speeds, and linearization can be performed without the need for a digital baseband input signal. The timing match between the input RF signal and predistorting signal, which is one of the critical factors for performance, was investigated and adjusted to obtain optimum performance. Using three-carrier cdmaOne and wide-band multitone signals, the linearization performances for a 0.5-W GaAs heterostructure field-effect transistor, a 90-W peak-envelope-power (PEP) silicon LDMOS PA, and a 680-W PEP LDMOS PA were examined. In addition, the predistortion performance variation for different signals was studied in terms of signal envelope statistics, output powers, and PA power capacities.
Hippocampal Sharp Wave-Ripples Linked to Slow Oscillations in Rat Slow-Wave Sleep (2006)

Slow oscillations originating in the prefrontal neocortex during slow-wave sleep (SWS) group neuronal network activity and thereby presumably support the consolidation of memories. Here, we investigated whether the grouping influence of slow oscillations extends to hippocampal sharp wave-ripple (SPW) activity thought to underlie memory replay processes during SWS. The prefrontal surface EEG and multiunit activity (MUA), along with hippocampal local field potentials (LFP) from CA1, were recorded in rats during sleep. Average spindle and ripple activity and event correlation histograms of SPWs were calculated, time-locked to half-waves of slow oscillations. Results confirm decreased prefrontal MUA and spindle activity during EEG slow oscillation negativity and increases in this activity during subsequent positivity. A remarkably close temporal link was revealed between slow oscillations and hippocampal activity, with ripple activity and SPWs being also distinctly decreased during negative half-waves and increased during slow oscillation positivity. Fine-grained analyses of temporal dynamics revealed for the slow oscillation a phase delay of approximately 90 ms with reference to up and down states of prefrontal MUA, and of only approximately 60 ms with reference to changes in SPWs, indicating that up and down states in prefrontal MUA precede corresponding changes in hippocampal SPWs by approximately 30 ms. Results support the notion that the depolarizing surface-positive phase of the slow oscillation and the associated up state of prefrontal excitation promotes hippocampal SPWs via efferent pathways. The preceding disfacilitation of hippocampal events temporally coupled to the negative slow oscillation half-wave appears to serve a synchronizing role in this neocorticohippocampal interplay.
MHC Class I–Related Chain A Conjugated to Antitumor Antibodies Can Sensitize Tumor Cells to Specific Lysis by Natural Killer Cells (2005)

These results open the way to the development of immunotherapy strategies based on antibody-mediated targeting of MICA.
Clinical Significance of Sphingosine Kinase-1 Expression in Human Astrocytomas Progression and Overall Patient Survival (2008)

SPHK1 might represent a novel and useful prognostic marker for astrocytoma and play a role during the development and progression of the disease.
Polyketal Nanoparticles:  A New pH-Sensitive Biodegradable Drug Delivery Vehicle (2005)

In this report, we present an acid-sensitive drug delivery vehicle, termed polyketal nanoparticles, which are designed to target therapeutics to the acidic environments of tumors, inflammatory tissues, and phagosomes. The polyketal nanoparticles are formulated from poly(1,4-phenyleneacetone dimethylene ketal) (PPADK), a new hydrophobic polymer which contains ketal linkages in its backbone. The polyketal nanoparticles undergo acid-catalyzed hydrolysis into low molecular weight hydrophilic compounds and should therefore release encapsulated therapeutics at an accelerated rate in acidic environments. Importantly, the polyketal nanoparticles do not generate acidic degradation products after hydrolysis, as with polyester-based biomaterials. Dexamethasone-loaded nanoparticles, 200-600 nm in diameter, were fabricated with PPADK via an emulsion procedure using chloroform and water. The hydrolysis half-life of PPADK was measured to be 102 h at pH 7.4 and 35 h at pH 5.0. PPADK was synthesized by a new polymerization strategy based on the acetal exchange reaction. This new delivery system should find numerous applications in the field of drug delivery because of its ease of synthesis and excellent degradation properties.
Novel curcumin- and emodin-related compounds identified by in silico 2D/3D conformer screening induce apoptosis in tumor cells (2005)

Our data demonstrate that the new in silico screening method is highly efficient for identifying potential anti-tumor drugs.
Retracted: Stable Plastid Transformation for High-Level Recombinant Protein Expression: Promises and Challenges (2014)

DOAJ is a unique and extensive index of diverse open access journals from around the world, driven by a growing community, committed to ensuring quality content is freely available online for everyone.
AR Binocular: Augmented Reality System for nautical navigation (2008)

Abstract: A realtime Augmented Reality binocular for the assistance of nautical staff is presented. AR systems combine the real environment with additional information. Nautical sea chart data is used to superimpose information into views with a magnification factor of 7 which cause a big effect on directional errors in the augmentation. We discuss the system requirements and present an analysis of the hardware components. The detection of the actual position is done without a magnetometer but using a gravity sensor in combination with an image-based marker tracking approach. It will be shown, that very high accuracies are achievable for the localization of real objects. 1
Proto-oncogene expression in rabbit aorta after wall injury First marker of the cellular process leading to restenosis after angioplasty? (1992)

In order to study the earliest phenomenons occurring in the arterial wall after balloon angioplasty, the level of expression of the proto-oncogenes, c-fos and c-myc, was studied in rabbit aorta after balloon denudation by using Northern blot analysis. Both c-fos and c-myc are rapidly and transitorily induced (maximal at 30 min and 2 h after mechanical injury for c-fos and c-myc respectively). By comparison, infusion of norepinephrine increases oncogene expression in normal non-denuded rabbit aorta after 1 h, but the combination of both mechanical and hormonal stimuli do not lead to a more important induction than balloon denudation alone.
TS-LSTM and Temporal-Inception: Exploiting Spatiotemporal Dynamics for Activity Recognition (2017)

Recent two-stream deep Convolutional Neural Networks (ConvNets) have made significant progress in recognizing human actions in videos. Despite their success, methods extending the basic two-stream ConvNet have not systematically explored possible network architectures to further exploit spatiotemporal dynamics within video sequences. Further, such networks often use different baseline two-stream networks. Therefore, the differences and the distinguishing factors between various methods using Recurrent Neural Networks (RNN) or convolutional networks on temporally-constructed feature vectors (Temporal-ConvNet) are unclear. In this work, we first demonstrate a strong baseline two-stream ConvNet using ResNet-101. We use this baseline to thoroughly examine the use of both RNNs and Temporal-ConvNets for extracting spatiotemporal information. Building upon our experimental results, we then propose and investigate two different networks to further integrate spatiotemporal information: 1) temporal segment RNN and 2) Inception-style Temporal-ConvNet. We demonstrate that using both RNNs (using LSTMs) and Temporal-ConvNets on spatiotemporal feature matrices are able to exploit spatiotemporal dynamics to improve the overall performance. However, each of these methods require proper care to achieve state-of-the-art performance; for example, LSTMs require pre-segmented data or else they cannot fully exploit temporal information. Our analysis identifies specific limitations for each method that could form the basis of future work. Our experimental results on UCF101 and HMDB51 datasets achieve state-of-the-art performances, 94.1% and 69.0%, respectively, without requiring extensive temporal augmentation.
Immunogenicity of a 24-Valent Klebsiella Capsular Polysaccharide Vaccine and an Eight-Valent Pseudomonas O-Polysaccharide Conjugate Vaccine Administered to Victims of Acute Trauma (1996)

We measured the antibody response in 10 victims of acute blunt trauma and penetrating trauma who were immunized against Klebsiella pneumoniae and Pseudomonas species within 72 hours of injury. The two vaccines, which were previously shown to be safe and immunogenic in uninjured humans, were a 24-valent K. pneumoniae capsular polysaccharide vaccine and an eight-valent Pseudomonas O-polysaccharide-toxin A conjugate vaccine. The patients were between 18 and 44 years of age, had Injury Severity Scores that ranged between 9 and 34, and did not have chronic infections or malignancies. On days 14 and 28 after immunization, all patients had a response of greater than fourfold to at least six of the nine Pseudomonas vaccine antigens. Half of the patients responded to eight of the nine antigens. Nine patients responded to at least 18 of 24 Klebsiella antigens, and seven patients responded to 22 of the 24 antigens. No important side effects were attributed to the vaccines. The results of this preliminary study indicate that active immunization against potential pathogens is possible in victims of acute trauma.
Apoptotic killing of B-chronic lymphocytic leukemia tumor cells by allicin generated in situ using a rituximab-alliinase conjugate (2005)

Allicin, a highly active component from freshly crushed garlic, is produced upon the reaction of the small molecular weight molecule alliin, with the enzyme alliinase (EC 4.4.1.4). Because allicin was shown to be toxic to various mammalian cells in vitro, we devised a novel approach for the therapy of B-cell malignancies based on site-directed generation of allicin. Alliinase was conjugated to the monoclonal antibody rituximab, which recognizes the CD20 antigen, and the resulting conjugate was targeted to CD20+ B chronic lymphocytic leukemia (B-CLL) and other B-cell lymphomas. Upon addition of alliin, allicin was formed in situ, killing the CD20+ tumor B cells via apoptosis. Following a 72-hour treatment, an 85% and 96% reduction was observed in the number of viable B-CLL and EBV-transformed B cells, respectively. Using the human/mouse radiation chimera for the evaluation of allicin targeting in a preclinical animal model, we showed a significant reduction in the number of recovered B-CLL, mantle cell lymphoma, or EBV-transformed B cells. We conclude that our system offers a new powerful and less toxic therapy for B-CLL and other B-cell malignancies. Furthermore, combining alliinase with the appropriate monoclonal antibody may extend the application of this approach to other conditions in which the elimination of a specific cell population is desired.
Cost-effectiveness of counseling and pedometer use to increase physical activity in the Netherlands: a modeling study (2012)

Counseling in combination with pedometer use aiming to increase physical activity may be a cost-effective intervention. However, the intervention only yields relatively small health benefits in the Netherlands.
Nearfield effects in end-fire line arrays (1973)

An “exact” closed-form solution for the acoustic field from a continuous end-fire line array is presented. Interactions between the array elements are ignored, but no approximations are made regarding the position of the field point. (This model lends itself particularly well to the study of the response of parametric receivers.) The results are presented in the form of beam patterns as a function of range. It is shown that the range where the transition between the nearfield and the farfield is obtained depends only on the length of the array and that the beam patterns within the nearfield can be substantially more narrow than the farfield beam patterns.
A 22nm SoC platform technology featuring 3-D tri-gate and high-k/metal gate, optimized for ultra low power, high performance and high density SoC applications (2012)

A leading edge 22nm 3-D tri-gate transistor technology has been optimized for low power SoC products for the first time. Low standby power and high voltage transistors exploiting the superior short channel control, < 65mV/dec subthreshold slope and <40mV DIBL, of the Tri-Gate architecture have been fabricated concurrently with high speed logic transistors in a single SoC chip to achieve industry leading drive currents at record low leakage levels. NMOS/PMOS Idsat=0.41/0.37mA/um at 30pA/um Ioff, 0.75V, were used to build a low standby power 380Mb SRAM capable of operating at 2.6GHz with 10pA/cell standby leakages. This technology offers mix-and-match flexibility of transistor types, high-density interconnect stacks, and RF/mixed-signal features for leadership in mobile, handheld, wireless and embedded SoC products.
Measurement of pain. (1983)

Abstract Of the various methods for measuring pain the visual analogue scale seems to be the most sensitive. For assessing response to treatment a pain-relief scale has advantages over a pain scale. Pain cannot be said to have been relieved unless pain or pain relief has been directly measured.
LQG Control of a Deformable Mirror Adaptive Optics System with Time- Delayed Measurements (1991)

This thesis proposes a linear quadratic Gaussian (LQG) control law for a ground-based deformable mirror adaptive optics system. The incoming image wavefront is distorted, primarily in phase, due to the turbulent effects of the earth's atmosphere. The adaptive optics system attempts to compensate for the distortion with a deformable mirror. A Hartman wavefront sensor measures the degree of distortion in the image wavefront. The measurements are input to a Kalman filter which estimates the system states. The state estimates are processed by a linear quadratic regulator which generates the appropriate control voltages to apply to the deformable mirror actuators. The dynamics model for the atmospheric phase distortion consists of 14 Zernike coefficient states; each modeled as a first-order linear time-invariant shaping filter driven by zero-mean white Gaussian noise. The dynamics of the deformable mirror are also model as 14 Zernike coefficients with first-order deterministic dynamics. A significant reduction in total wavefront phase distortion is achieved in the presence of time-delayed measurements. Wavefront sensor sampling rate is the major factor limiting system performance. The Multimode Simulation for Optimal Filter Evaluation (MSOFE) software is the performance evaluation tool of choice for this research.
Overcoming Thermodynamic and Kinetic Limitations of Aldolase‐Catalyzed Reactions by Applying Multienzymatic Dynamic Kinetic Asymmetric Transformations (2007)

Dynamic and successful: The asymmetric synthesis of 2-amino-1-phenylethanol was achieved by aminomethylation of benzaldehyde in the presence of the two enzymes L-threonine aldolase and L-tyrosine decarboxylase in a novel one-pot, two-enzyme process (see scheme). A modified method with three enzymes led to the enantioenriched amino alcohol in very high yield. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z604142_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Expression and Characterization of a DNase I-Fc Fusion Enzyme (1999)

Recombinant human deoxyribonuclease I (DNase I) is an important clinical agent that is inhaled into the airways where it degrades DNA to lower molecular weight fragments, thus reducing the viscoelasticity of sputum and improving the lung function of cystic fibrosis patients. To investigate DNases with potentially improved properties, we constructed a molecular fusion of human DNase I with the hinge and Fc region of human IgG1 heavy chain, creating a DNase I-Fc fusion protein. Infection of Sf9 insect cells with recombinant baculovirus resulted in the expression and secretion of the DNase I-Fc fusion protein. The fusion protein was purified from the culture medium using protein A affinity chromatography followed by desalting by gel filtration and was characterized by amino-terminal sequence, amino acid composition, and a variety of enzyme-linked immunosorbent assays (ELISA) and activity assays. The purified fusion contains DNase I, as determined by a DNase I ELISA and an actin-binding ELISA, and an intact antibody Fc region, which was quantified by an Fc ELISA, in a 2:1 stoichiometric ratio, respectively. The dimeric DNase I-Fc fusion was functionally active in enzymatic DNA digestion assays, albeit about 10-fold less than monomeric DNase I. Cleavage of the DNase I-Fc fusion by papain resulted in a specific activity comparable to the monomeric enzyme. Salt was inhibitory for wild type monomeric DNase I but actually enhanced the activity of the dimeric DNase I-Fc fusion. The DNase I-Fc fusion protein was also less Ca2+-dependent than DNase I itself. These results are consistent with a higher affinity of the dimeric fusion protein to DNA than monomeric DNase I. The engineered DNase I-Fc fusion protein described herein has properties that may have clinical benefits.
Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma (2011)

EGFR and IGF-1R expression, in neoplastic and stromal cells, seems to be an important prognostic factor.
Collagen crosslinking in the management of advanced non-resolving microbial keratitis (2014)

CXL appears to be an effective procedure in the management of superficial microbial keratitis. It can be used as an adjunctive treatment in the management of non-resolving microbial keratitis.
Enrichment of Armchair Carbon Nanotubes via Density Gradient Ultracentrifugation: Raman Spectroscopy Evidence (2010)

We have used resonant Raman scattering spectroscopy to fully analyze the relative abundances of different (n,m) species in single-walled carbon nanotube samples that are metallically enriched by density gradient ultracentrifugation. Strikingly, the data clearly show that our density gradient ultracentrifugation process enriches the metallic fractions in armchair and near-armchair species. We observe that armchair carbon nanotubes constitute more than 50% of each (2n + m) family.
Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice (2010)

Inappropriate excess of the steroid hormone aldosterone, which is a mineralocorticoid receptor (MR) agonist, is associated with increased inflammation and risk of cardiovascular disease. MR antagonists are cardioprotective and antiinflammatory in vivo, and evidence suggests that they mediate these effects in part by aldosterone-independent mechanisms. Here we have shown that MR on myeloid cells is necessary for efficient classical macrophage activation by proinflammatory cytokines. Macrophages from mice lacking MR in myeloid cells (referred to herein as MyMRKO mice) exhibited a transcription profile of alternative activation. In vitro, MR deficiency synergized with inducers of alternatively activated macrophages (for example, IL-4 and agonists of PPARgamma and the glucocorticoid receptor) to enhance alternative activation. In vivo, MR deficiency in macrophages mimicked the effects of MR antagonists and protected against cardiac hypertrophy, fibrosis, and vascular damage caused by L-NAME/Ang II. Increased blood pressure and heart rates and decreased circadian variation were observed during treatment of MyMRKO mice with L-NAME/Ang II. We conclude that myeloid MR is an important control point in macrophage polarization and that the function of MR on myeloid cells likely represents a conserved ancestral MR function that is integrated in a transcriptional network with PPARgamma and glucocorticoid receptor. Furthermore, myeloid MR is critical for blood pressure control and for hypertrophic and fibrotic responses in the mouse heart and aorta.
Molecular Pathogenesis of Polycythemia Induced in Mice by JAK2 V617F. (2005)

Abstract A somatic mutation (V617F) in the JH2 pseudokinase domain of the JAK2 tyrosine kinase is found in the majority of patients with polycythemia vera (PV), and some patients with essential thrombocythemia (ET) and chronic idiopathic myelofibrosis (CIMF). The JAK2 V617F mutant is constitutively active and induces polycythemia in mice after retroviral expression in transplanted bone marrow (James et al., Nature2005; 434:1144). We expressed murine JAK2 wild-type (WT) or a JAK2 V617F mutant in bone marrow (BM) using retroviral transduction and transplantation in two different strains of inbred mice, C57Bl/6 (B6) and Balb/c. In both B6 and Balb/c mice, JAK2 V671F induced non-fatal polycythemia characterized by increased hematocrit and hemoglobin, reticulocytosis, and splenomegaly that were manifest by 3 weeks post-transplantation and were sustained for months. JAK2 V617F also induced significant leukocytosis and neutrophilia that was much more pronounced in Balb/c mice than in B6. Platelet counts were not significantly increased in either strain, despite expression of the mutant JAK2 kinase in megakaryocytes. By contrast, peripheral blood counts in recipients of BM transduced with JAK2 WT were normal and not significantly different from recipients of vector-transduced BM. We also employed BM from donor mice with mutations in erythropoiesis signaling pathways to analyze the pathogenesis of PV. Mice lacking the Src family kinase Lyn or with deficiency of both Stat5a and Stat5b have normal hematopoiesis as adults, but exhibit defects in stress and fetal erythropoiesis. JAK2 V617F efficiently induced polycythemia in BM from mice lacking the Src kinases Lyn, Hck and Fgr. By contrast, deficiency of both Stat5a and Stat5b in the donor BM attenuated the polycythemia and reticulocytosis induced by JAK2 V617F. These results demonstrate that the principal effect of expression of JAK2 V617F in hematopoietic stem/progenitor cells is expansion of the erythroid lineage through a Stat5-dependent, Src kinase-independent pathway. The strain-dependent leukocytosis suggests that genetic modifiers affect the hematopoietic phenotype of this activated JAK2 mutation. The lack of thrombocytosis implies that additional events may be required for JAK2 V617F to cause essential thrombocythemia.