gebhart/patrepeval huggingface dataset:
META‐ANALYSIS OF THE RELATIONSHIP BETWEEN THE FIVE‐FACTOR MODEL OF PERSONALITY AND HOLLAND'S OCCUPATIONAL TYPES (2003)

The purpose of this study is to examine the nature and magnitude of the relationship between 2 widely accepted models for classifying individual differences–the 5‐factor model of personality and Holland's RI‐ASEC occupational types. Based on extensive meta‐analyses, our results illustrate that there are meaningful relations between some FFM personality dimensions and some RIASEC types. The strongest relationships were obtained between the RIASEC types of enterprising and artistic with the FFM personality dimensions of Extraversion and Openness to Experience, p = .41 and .39, respectively. Three other RIASEC types had moderate correlations with at least 1 FFM personality trait. In contrast, the realistic type was not related to any FFM personality traits. Multiple regression analyses in which each RIASEC type is regressed on the FFM scores (based on meta‐analytic estimates), revealed a multiple R of .11 for realistic, .26 for investigative, .42 for artistic, .31 for social, .47 for enterprising, and .27 for conventional types. The overall conclusion from the study is that although FFM personality traits and RIASEC types are related, they are not merely substitutes for each other.
Factor Activity Assays for Monitoring Extended Half-Life FVIII and Factor IX Replacement Therapies (2017)

The advent of modified factor VIII (FVIII) and factor IX (FIX) molecules with extended half-lives (EHLs) compared with native FVIII and FIX represents a major advance in the field of hemophilia care, with the potential to reduce the frequency of prophylactic injections and/or to increase the trough level prior to subsequent injections. Monitoring treatment through laboratory assays will be an important part of ensuring patient safety, including any tailoring of prophylaxis. Several approaches have been used to extend half-lives, including PEGylation, and fusion to albumin or immunoglobulin. Some of these modifications affect factor assays as routinely performed in hemophilia centers; so, laboratories will need to use FVIII and FIX assays which have been shown to be suitable on a product-by-product basis. For some products, there are marked differences between results obtained using one-stage or chromogenic assays and results obtained using different reagents in the one-stage assay. The laboratory should use an assay in which the recovery of the product closely aligns with the assay used by the pharmaceutical company to assign potency to the product, so that the units reported by the laboratory agree with those used to demonstrate efficacy of the product during clinical trials. Reported assay differences in relation to several of the EHL FVIII and FIX molecules will be reviewed in this article.
Xylo- and arabinofuranosylthioguanine and related nucleosides derived from 2-acetamido-6-chloropurine (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTXylo- and arabinofuranosylthioguanine and related nucleosides derived from 2-acetamido-6-chloropurineWilliam W. Lee, Abelardo P. Martinez, Robert W. Blackford, Victor J. Bartuska, Elmer J. Reist, and Leon GoodmanCite this: J. Med. Chem. 1971, 14, 9, 819–823Publication Date (Print):September 1, 1971Publication History Published online1 May 2002Published inissue 1 September 1971https://pubs.acs.org/doi/10.1021/jm00291a011https://doi.org/10.1021/jm00291a011research-articleACS PublicationsRequest reuse permissionsArticle Views182Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Octreotide as a Rapid and Effective Painkiller for Metastatic Carcinoid Tumor (2005)

Octreotide is one of the somatostatin analogue used for the treatment of endocrine tumors principally to suppress hormone secretion and to inhibit tumor growth. We experienced a case with multiple endocrine neoplasia type 1 who small amount of octreotide dramatically relieved the lumber pain caused by metastatic bone tumor. He had recurrent bronchial carcinoid tumors that metastasized to liver and bones. The spontaneous and radiated pain by bone tumors subsided within a few minutes after the initial injection of octreotide and the effect persisted for several hours. Combination therapy of octreotide and interferon alpha-2b significantly reduced the size of metastatic liver tumors and inhibited further growth of metastatic bone tumors for the last 27 months. The use of octreotide may be a good option for controlling pain by metastatic bone disease and combination therapy of octreotide and interferon alpha-2b is worth to try for patients with inoperable metastatic carcinoid tumor.
Nuclear translocation of viral Jun but not of cellular Jun is cell cycle dependent. (1992)

The Jun protein is a transcription factor of the AP-1 complex, and it is concentrated in the cell nucleus. While the cellular Jun protein is transported into the nucleus in a cell-cycle-independent fashion, the oncogenic viral version of the protein translocates into the nucleus most rapidly during the G2 phase of the cell cycle and only slowly during G1 and S phases. This cell cycle dependence of nuclear transport has been mapped to the cysteine to serine mutation in the carboxyl-terminal portion of viral Jun. We have identified a complex nuclear translocation signal located in the basic region of viral Jun. This signal has the sequence ASKSRKRKL. A peptide of this sequence synthesized in vitro and conjugated to IgG can mediate cell-cycle-dependent translocation of the microinjected conjugate from the cytoplasm into the nucleus. The nuclear translocation signal has two functional domains. The pentapeptide RKRKL is sufficient as a cell-cycle-independent nuclear address. The entire signal is needed for cell-cycle-dependent nuclear translocation. The amino-terminal tetrapeptide contains the cysteine to serine substitution responsible for cell cycle dependence. Deletion analysis of the Jun protein suggests that the nuclear translocation signal identified in the basic region is required for nuclear translocation of Jun and may be the only such signal in the Jun molecule.
Pharmacologic amino acid acylation in the acute hyperammonemia of propionic acidemia (1987)

An infant with propionic acidemia presented at one month of age with hyperammonemic coma. Treatment by two double-volume exchange transfusions did not have an appreciable effect, but hemodialysis led to a substantial reduction of the serum concentration of ammonia on two occasions. Nevertheless, continued therapy with sodium benzoate, arginine-HCl, carnitine and lactulose did not have any observable effect on the blood concentration of ammonia. Treatment with sodium phenylacetate was followed by a reduction in serum concentrations of ammonia to normal levels which were maintained. These observations demonstrate the dramatic reduction in serum concentrations of ammonia that may be obtained in patients with organic acidemia by hemodialysis. They suggest that pharmacologic acylation therapy with phenylacetate may be of lasting benefit in the management of this complication.
Electroporation of Adherent Cells In Situ (1990)

A simple, rapid, and reproducible procedure for the introduction of macromolecules into adherent mammalian cells by electroporation is described. Cells were growing on a glass surface coated with electrically conductive, optically transparent indium-tin oxide at the time of pulse delivery. Several factors affected the optimal voltage for permeation of a given line including the metabolic state of the cells and their degree of spreading onto the conductive growth surface. Careful control of the electric field strength resulted in almost 100% of the cells containing introduced antibodies without any detectable change in the length of their division cycle. Higher voltages were required for the stable expression of DNA than for the introduction of antibodies, resulting in a significant rate of cell death.
Effects of Okinawan sugar cane wax and fatty alcohol on serum and liver lipids in the rat. (1984)

Partially purified Okinawan sugar cane wax and fatty alcohol were fed to Wistar strain rats to examine the effects on serum and liver cholesterol (Chol), triglyceride (TG) and phospholipid (PL). The fecal excretion of neutral sterols in the rats was also determined. There were no significant differences found in the body weight gain, food intake and liver weight among the animals of experimental diet groups. An addition of 0.5% sugar cane wax to the diet significantly lowered the concentrations of serum and liver Chol in the rats. There were no significant differences observed in PL and TG levels either in serum or liver among the experimental groups. These results indicate that cane wax, one of the elements contained in sugar cane rind as well as in black sugar, may have a cholesterol-lowering effect on the serum and liver of the rats. The amount of feces excreted by the three experimental diet groups of rats were exactly the same and also no significant differences were found in the excretion of Chol.
Haplotyping and copy number estimation of the highly polymorphic human beta-defensin locus on 8p23 by 454 amplicon sequencing (2010)

Deep amplicon sequencing using the 454 technology yield thousands of HCs per amplicon for an affordable price and may represent an effective method for parallel haplotyping and CN estimation in small to medium-sized cohorts. The obtained haplotypes represent a valuable resource to facilitate further studies of the biomedical impact of highly CN variable loci such as the beta-defensin locus.
ACS NEWS (1993)

RETURN TO ISSUEPREVACS NewsNEXTACS NEWSCongressional Visits Day ends wfth chemistry showLINDA ROSSCite this: Chem. Eng. News 1993, 71, 18, 47–48Publication Date (Print):May 3, 1993Publication History Published online11 November 2010Published inissue 3 May 1993https://pubs.acs.org/doi/10.1021/cen-v071n018.p047https://doi.org/10.1021/cen-v071n018.p047acs-newsACS PublicationsCopyright © 1993 AMERICAN CHEMICAL SOCIETY. This publication is available under these Terms of Use. This publication is free to access through this site. Learn MoreArticle Views64Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (761 KB) SUBJECTS:Environmental science Get e-Alerts
β‐Amyloid immunization approaches for Alzheimer's disease (2002)

Abstract Alzheimer's disease (AD) represents the third leading cause of death in the U.S. and the leading cause of dementia in the elderly population. Until recently, there was little hope of efficiently combating this devastating disease. The deposition of β‐amyloid (Aβ) is the major pathological hallmark of AD brains. Genetic, biochemical, and pharmacological evidence support the hypothesis that Aβ plays a key role in the development of the disease. Thus, in the last 5 years a number of pharmacological strategies have been developed to interfere with the Aβ cascade. The most revolutionary of these approaches was proposed in 1999 by scientists at Elan Pharmaceuticals, which immunized against Aβ transgenic mice with spontaneously developing Aβ pathology. The immunization was achieved by subcutaneous injections of a preaggregated form of the synthetic human 42‐amino acid Aβ emulsified with Freund's adjuvant, an immune stimulant. The vaccination caused a near complete inhibition of Aβ plaque formation in younger animals and a marked reduction of the Aβ burden in older animals. The effects on Aβ plaques were accompanied by a reduction of Aβ‐associated astrogliosis and neuritic dystrophy. These results were later confirmed by other groups with similar vaccination protocols, which also demonstrated that the Aβ immunization of transgenic animals normalize or reduce the cognitive impairment associated with Aβ pathology. Interestingly, effective removal of brain Aβ plaques was also obtained by peripherally administering Aβ antibodies. The mechanism with which the vaccine increases Aβ clearance is not fully understood. Centrally, the vaccine appears to activate Aβ phagocytosis by microglial monocytes. Peripherally, serum Aβ antibodies bind and sequester Aβ, thus altering its equilibrium between CNS and plasma. The dramatic results obtained in animal models of AD raised unprecedented hopes for both a preventive and a curative intervention for this devastating disorder. A vaccine preparation for human use (AN‐1792) composed of preaggregated human Aβ42 peptide and a highly purified saponin derivative (QS‐21) was developed by Elan Pharmaceuticals and Wyeth Ayerst and tested in AD patients. Unfortunately, a Phase IIa study aimed at evaluating the safety and immunological activity of AN‐1792 in 360 AD patients was discontinued because 15 subjects receiving the vaccine developed serious signs of CNS inflammation. Both central activation of cytotoxic T cells and autoimmune reactions were proposed as potential mechanisms of toxicity. Other therapeutic Aβ vaccination strategies are being pursued, including immuno‐conjugates and monoclonal antibodies. The future of these and other Aβ immunization approaches depend on a clear understanding of the mechanism of Aβ clearance and additional insight into the role of inflammation in the AD brain. Drug Dev. Res. 56:150–162, 2002. © 2002 Wiley‐Liss, Inc.
Round-robin scheduling for max-min fairness in data networks (1991)

The author studies a simple strategy, proposed independently by E.L. Hahne and R.G. Gallager (1986) and M.G.H. Katevenis (1987), for fairly allocating link capacity in a point-to-point packet network with virtual circuit routing. Each link offers its packet transmission slots to its user sessions by polling them in round-robin order. In addition, window flow control is used to prevent excessive packet queues at the network nodes. As the window size increases, the session throughput rates are shown to approach limits that are perfectly fair in the max-min sense. If each session has periodic input (perhaps with jitter) or has such heavy demand that packets are always waiting to enter the network, then a finite window size suffices to produce perfectly fair throughput rates. The results suggest that the transmission capacity not used by the small window session will be approximately fairly divided among the large window sessions. The focus is on the worst-case performance of round-robin scheduling with windows.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
In-situ Real-time Field Imaging and Monitoring of Leaf Stomata by High-resolution Portable Microscope (2019)

ABSTRACT Stomata, functionally specialized micrometer-sized pores on the epidermis of leaves (mainly on the lower epidermis), control the flow of gases and water between the interior of the plant and atmosphere. Real-time monitoring of stomatal dynamics can be used for predicting the plant hydraulics, photosensitivity, and gas exchanges effectively. To date, several techniques offer the direct or indirect measurement of stomatal dynamics, yet none offer real-time, long-term persistent measurement of multiple stomal apertures simultaneously of an intact leaf in a field under natural conditions. Here, we report a high-resolution portable microscope-based technique for in situ real-time field imaging and monitoring of stomata. Our technique is capable of analyzing and quantifying the multiple lower epidermis stomal pore dynamics simultaneously and does not require any physical or chemical manipulation of a leaf. An upward facing objective lens in our portable microscope allows the imaging of lower epidermis stomatal opening of a leaf while upper epidermis being exposed to the natural environment. Small depth of field (~ 1.3 μm) of a high-magnifying objection lens assists in focusing the stomatal plane in highly non-planar tomato leaf having a high density of trichome (hair-like structures). For long-term monitoring, the leaf is fixed mechanically by a novel designed leaf holder providing freedom to expose the upper epidermis to the sunlight and lower epidermis to the wind simultaneously. In our study, a direct relation between the stomatal opening and the intensity of sunlight illuminating on the upper epidermis has been observed in real-time. In addition, real-time porosity of leaf (ratio between the areas of stomatal opening to the area of a leaf) and stomatal aspect ratio (ratio between the major axis and minor axis of stomatal opening) along with stomatal density have been quantified.
Nanometer spaced electrodes using selective area atomic layer deposition (2007)

Nanoelectrodes with spacing controlled between 1 and 10nm with subnanometer increment have been achieved using atomic layer deposition. Field emission and metal-vacuum-metal tunneling are used to characterize the electrode properties in situ during growth. The current-voltage data is modeled and gives electrode spacing of 1.0±0.2nm, a barrier height of 4.5eV, and electrode radius of 10nm. Temperature variation from 26to235°C changes the spacing by 0.05nm, as calculated from electrical data. This is close to 0.1nm expected from thermal expansion. Exposing to air reduces the barrier height to 2.15eV, which is explained by the growth of a thin metal oxide layer.
Quantitative Analysis of Bowel Gas Using Plain Abdominal Radiograph in Patients With Irritable Bowel Syndrome (2000)

Abdominal gas was analyzed objectively by using GVS, and GVS was considered to represent a useful tool for the diagnosis of IBS.
Cell attachment to extracellular matrix substrates is inhibited upon downregulation of expression of calreticulin, an intracellular integrin α-subunit-binding protein (1994)

We have demonstrated recently that calreticulin, an intracellular calcium-binding protein, can interact with the alpha-subunits of integrin receptors via the highly conserved KXGFFKR amino acid sequence present in the cytoplasmic domains of all integrin alpha-subunits (Rojiani et al. (1991) Biochemistry 30, 9859-9866). Here we demonstrate that calreticulin can be co-localized by immunofluorescence as well as co-purified with integrins, that recombinant calreticulin can also interact with integrins, and that the interaction occurs predominantly via the N-domain of calreticulin, to a much lesser extent with the C-domain, but not at all with the proline-rich P-domain. To demonstrate a physiological role for the interaction of calreticulin with integrins, calreticulin expression was downregulated by treating cells with antisense oligonucleotides designed to inhibit the initiation of translation of calreticulin. Antisense oligonucleotides, but not sense or non-sense oligonucleotides, inhibited attachment and spreading of cells cultured in the presence of fetal bovine serum, and also of cells plated on individual extracellular matrix substrates in the absence of serum. The antisense oligonucleotide inhibited cell proliferation of anchorage-dependent cells slightly, but there was no effect on cell viability. The effect on cell attachment was similar to that achieved by treating cells with an antisense oligonucleotide designed to inhibit translation of the integrin alpha 3 subunit, which resulted in the inhibition of cell attachment to alpha 3 beta 1-specific substrates. The effect of the antisense calreticulin oligonucleotide on cell attachment was demonstrated to be integrin-mediated since antisense calreticulin treatment of Jurkat cells abrogated the stimulation of collagen cell attachment achieved by attachment-stimulating signalling anti-alpha 2 (JBS2) and anti-beta 1 (21C8) antibodies. The oligonucleotides did not affect the rate of cell proliferation of these cells. These results demonstrate a fundamental role of calreticulin in cell-extracellular matrix interactions.
Antibody engineering : a practical guide (1992)

Containing the latest developments in one of the fastest growing fields in molecular biology, this monograph should help scientists construct designer human and mouse monoclonal antibodies using state-of-the-art technology. Antibody Engineering provides a complete overview of antibody structure, plant and mammalian expression vectors and hosts, recombinatorial cDNA libraries, PCR single-cell cloning and engineering of affinity and biological effector functions. Each chapter focuses on a particular aspect fo antibody engineering and is written by a leading expert in the field.
Transforming growth factor beta 1, a potent chemoattractant for human neutrophils, bypasses classic signal-transduction pathways. (1991)

Transforming growth factor beta 1 (TGF-beta 1), a homodimeric polypeptide (Mr 25,000), derives from inflammatory cells and acts as a chemoattractant for monocytes and fibroblasts. We report here that TGF-beta 1 is also the most potent chemoattractant yet described for human peripheral blood neutrophils. Recombinant TGF-beta 1 elicited dose-dependent directed migration of neutrophils under agarose that was inhibited in the presence of a neutralizing antibody to TGF-beta 1. Maximal chemotaxis was evoked by TGF-beta 1 at femtomolar concentrations, whereas conventional chemoattractants act at nanomolar concentrations: on a molar basis, TGF-beta 1 was 150,000 times more potent than fMet-Leu-Phe. In contrast, TGF-beta 1 provoked neither exocytosis nor the production of superoxide by neutrophils. We further analyzed the mechanism by which TGF-beta 1 elicits chemotaxis (GTPase activity, [Ca2+], and actin polymerization). In contrast to the conventional chemoattractant fMet-Leu-Phe, TGF-beta neither activated classic heterotrimeric guanine nucleotide-binding proteins nor provoked global mobilization of intracellular Ca2+. Chemoattraction by both fMet-Leu-Phe and TGF-beta 1 was inhibited by cycloheximide and actinomycin D. Moreover, chemotaxis in response to TGF-beta 1 was associated with the polymerization of actin. The selectivity and potency of TGF-beta 1 as a chemoattractant suggest that it elicits directed cell migration by means of a pathway that depends not on classic intracellular signals but on protein synthesis.