gebhart/patrepeval huggingface dataset:
A simulation study of high-capacity cellular land-mobile radio-communication systems (1982)

Considers the problem of channel assignment in Land-Mobile Radiocommunication systems. The performance of the hybrid assignment scheme under various loading conditions is evaluated by using simulation results of channel that has a cellular mobile communications system forty cells with Erlang-B service. In addition the hybrid system is compared to the fixed and dynamic systems with respect to the maximum transmission per cell that each system can support, while having a call rejection rate of no more than 2 per cent. For the same cellular system the minimum number of necessary channels (in order to establish a given quality of service for various traffic load. A conclusion is offered per cell) is determined. A conclusion reached regarding the spectral efficiency of hybrid systems with respect to the fixed systems.
A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload (2012)

This was a 24-week, multicenter phase-2 study designed to assess safety, tolerability, and pharmacodynamics of FBS0701, a novel oral chelator, in adults with transfusional iron overload. Fifty-one patients, stratified by transfusional iron intake, were randomized to FBS0701 at either 14.5 or 29 mg/kg/d (16 and 32 mg/kg/d salt form). FBS0701 was generally well tolerated at both doses. Forty-nine patients (96%) completed the study. There were no drug-related serious adverse events. No adverse events (AEs) showed dose-dependency in frequency or severity. Treatment-related nausea, vomiting, abdominal pain, and diarrhea were each noted in < 5% of patients. Mean serum creatinine did not change significantly from Baseline or between dose groups. Transaminases wer increased in 8 (16%), three of whom acquired HCV on-study from a single blood bank while five had an abnormal baseline ALT. The 24 week mean change in liver iron concentration (ΔLIC) at 14.5 mg/kg/d was +3.1 mg/g (dw); 29% achieved a decrease in LIC. Mean ΔLIC at 29 mg/kg/d was -0.3 mg/g (dw); 44% achieved a decrease in LIC (P < .03 for ΔLIC between doses). The safety and tolerability profile at therapeutic doses compare favorably to other oral chelators.
Grafting onto preformed polyester network using thermolabile azo groups (1990)

Abstract Polycondensation of 4,4‐azo‐bis(cyanopentanoyl chloride) and o ‐phthalyl chloride between polyethylene glycol with addition of glycerine leads to polyester networks containing thermolabile azo groups. The networks have been characterized in terms of their swelling in benzene, chlorobenzene, and methacrylonitrile. Grafting of methacrylonitrile onto these preformed networks was then achieved by thermal decomposition of NN groups in the presence of methacrylonitrile.
GeoLife: A Collaborative Social Networking Service among User, Location and Trajectory. (2010)

People travel in the real world and leave their location history in a form of trajectories. These trajectories do not only connect locations in the physical world but also bridge the gap between people and locations. This paper introduces a social networking service, called GeoLife, which aims to understand trajectories, locations and users, and mine the correlation between users and locations in terms of usergenerated GPS trajectories. GeoLife offers three key applications scenarios: 1) sharing life experiences based on GPS trajectories; 2) generic travel recommendations, e.g., the top interesting locations, travel sequences among locations and travel experts in a given region; and 3) personalized friend and location recommendation. 1
The architecture and implementation of a distributed hypermedia storage system (1993)

Article The architecture and implementation of a distributed hypermedia storage system Share on Authors: Douglas E. Shackelford Department of Computer Science, University of North Carolina, Chapel Hill, North Carolina Department of Computer Science, University of North Carolina, Chapel Hill, North CarolinaView Profile , John B. Smith Department of Computer Science, University of North Carolina, Chapel Hill, North Carolina Department of Computer Science, University of North Carolina, Chapel Hill, North CarolinaView Profile , F. Donelson Smith View Profile Authors Info & Claims HYPERTEXT '93: Proceedings of the fifth ACM conference on HypertextDecember 1993 Pages 1–13https://doi.org/10.1145/168750.168753Published:01 December 1993 23citation491DownloadsMetricsTotal Citations23Total Downloads491Last 12 Months2Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Advances in understanding the pathogenesis of HLH (2013)

Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory disorder resulting from immune dysfunction reflecting either primary immune deficiency or acquired failure of normal immune homeostasis. Familial HLH includes autosomal recessive and X-linked disorders characterized by uncontrolled activation of T cells and macrophages and overproduction of inflammatory cytokines, secondary to defects in genes encoding proteins involved in granule-dependent cytolytic pathways. In older children and adults, HLH is associated more often with infections, malignancies, autoimmune diseases, and acquired immune deficiencies. HLH, macrophage activation syndrome, sepsis, and systemic inflammatory response syndrome are different clinical entities that probably represent a common immunopathological state, termed cytokine storm. These conditions may be clinically indistinguishable; all include massive inflammatory response, elevated serum cytokine levels, multi-organ involvement, haemophagocytic macrophages, and often death. Tissues of haematopoietic and lymphoid function are directly involved; other organs are secondarily damaged by circulating cytokines and chemokines. Haemophagocytic disorders are now increasingly diagnosed in the context of severe inflammatory reactions to viruses, malignancies and systemic connective tissue diseases. Many of these cases may reflect underlying genetic predispositions to HLH. The detection of gene defects has contributed considerably to our understanding of HLH, but the mechanisms leading to acquired HLH have yet to be fully determined.
Adenovirus Infections in Young Children (1985)

The importance of adenovirus in initiating respiratory disease in young children is stressed in this report. The incidence, clinical illness, asymptomatic carriage, and serologic response of acute adenovirus-associated infection are described in a carefully followed cohort of normal children cultured with each episode of febrile respiratory illness. During a 6-year period, 8.2% of 1,416 nasal washings obtained from sick infants and children less than 7 years of age yielded adenovirus. Adenoviruses were isolated from only 1/174 (0.6%) cultures taken from well children. Typing of 98 isolates showed 81% to be types 1 or 2. A ≥ fourfold rise in neutralizing titer was seen in 45/59 (76%) sampled. In a subset of the cohort observed for 2-week periods in a day care setting, 14 of 21 well children (67%) exposed to symptomatic children with adenovirus infection developed febrile respiratory symptoms and shedding of the same serotype within 2 weeks of exposure. This study confirms that adenovirus has a high attack rate and causes significant respiratory disease in young children.
Inhibition of gap junctional intercellular communication and enhancement of growth in BALB/c 3t3 cells treated with connexin43 antisense oligonucleotides (1995)

Many studies have correlated reductions in gap junctional intercellular communication (GJIC) with altered cellular growth, tumor promotion, and neoplastic transformation. To test directly whether reduced GJIC affects cellular growth, GJIC was inhibited in murine BALB/c 3T3 fibroblasts by treatment with a phosphorothioate-modified antisense oligonucleotide targeted against the connexin43 translation start codon, and in vitro cell growth was monitored. The cells were incubated with the oligonucleotide (0.1-0.5 microM) in liposomes in serumless culture medium for 16 h; washed and refed with serum-containing medium; and analyzed for dye-coupling, connexin43 protein and mRNA levels, and cell growth over the next 5 d. The antisense oligonucleotide inhibited dye-coupling and reduced connexin43 protein levels in a concentration-dependent manner but had no effect on connexin43 mRNA levels. Cell growth rate was not affected, but saturation density was increased approximately threefold by the oligonucleotide. These data support a role for GJIC in the establishment of contact inhibition of in vitro cell growth.
Effect of calcitonin gene-related peptide on coronary microvessels and its role in acute myocardial ischemia. (1994)

BACKGROUND Calcitonin gene-related peptide (CGRP) is a potent dilator of epicardial conduit vessels and is released during myocardial ischemia in humans. However, the effect of CGRP on coronary arterial microvessels is still unclear, and it is unknown if CGRP modulates the tone of coronary arterial microvessels during acute myocardial ischemia. METHODS AND RESULTS Epimyocardial microvessels were observed through a microscope equipped with a floating objective system in anesthetized open-chest dogs. Heart rate and aortic pressure were maintained at control levels. Flow velocity of the left anterior descending coronary artery (LAD) was measured with a suction-cup Doppler probe. When CGRP was cumulatively infused into the LAD (0.05, 0.5, 5.0, and 50 pmol/kg per minute) or superfused (0.03, 0.3, 3.0, and 30 nmol/L) over the left ventricular surface, arterial control microvessels &gt; 100 microns in diameter dilated dose dependently at dosages of 0.5 to 50 pmol/kg per minute (infused) or 0.3 to 30 nmol/L (superfused), but those &lt; 100 microns dilated only at the highest dose, and those &gt; 100 microns had greater dilation in both groups. Only the highest dose of CGRP (infused) significantly increased coronary flow. The superfusion of CGRP(8-37) (CGRP receptor antagonist, 300 nmol/L) did not affect the control diameters of coronary arterial microvessels but completely abolished CGRP-induced vasodilation at the same doses (infused and superfused). However, 300 nmol/L of CGRP(8-37) did not affect the response of coronary arterial microvessels to the LAD occlusion in any size. CONCLUSIONS CGRP preferentially dilates the coronary arterial microvessels &gt; 100 microns in diameter but has only a small effect on those &lt; 100 microns. Endogenous CGRP does not modulate the tone of coronary arterial microvessels during acute myocardial ischemia in beating canine hearts.
Effect of Wave Form on Let-Go Currents (1943)

This paper is a continuation of ``Effect of Frequency on Let-Go Currents'' <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and concludes studies made to determine let-go currents. This paper extends the analysis to cover various wave shapes and includes a method of determining reasonably safe currents for men, women, and children, for sine waves, direct current, and complex wave forms containing both a-c and d-c components. As in previous papers, conclusions regarding reasonably safe electric currents are based on the criterion that a safe current is the let-go current for 99½ per cent of a large group of healthy subjects.
Rising incidence of adenocarcinoma of the esophagus and gastric cardia (1991)

Analyses of cancer incidence data from nine areas of the United States revealed steadily rising rates from 1976 to 1987 of adenocarcinomas of the esophagus and gastric cardia. The increases among men in this period ranged from 4% to 10% per year, and thus exceeded those of any other type of cancer. In contrast, there were relatively stable trends for squamous cell carcinoma of the esophagus and slight declines for adenocarcinoma of more distal portions of the stomach. Adenocarcinomas of the esophagus and gastric cardia disproportionately affected white men and rarely occurred among women. By the mid-1980s. among white men, adenocarcinomas accounted for about one third of all esophageal cancers, while cardia cancers accounted for about one half of all stomach cancers with specified subsites. The rising incidence rates and similar demographic patterns point to the need for investigation into the causes of these poorly understood cancers. (<i>JAMA</i>. 1991;265:1287-1289)
106 W continuous-wave output power from vertical-external-cavity surface-emitting laser (2012)

A report is presented on an optically-pumped semiconductor disk laser providing a continuous-wave output power of 106 W at a heatsink temperature of 3 °C. The laser, which operates in the transversal multimode regime, emits at a wavelength of 1028 nm. This high output power is achieved by carefully optimising the chip design, the growth process, and the bonding layer.
Photobactericidal activity of phenothiazinium dyes against methicillin-resistant strains ofStaphylococcus aureus (1998)

The photodynamic antibacterial properties of a closely related series of phenothiazinium dyes were tested against several pathogenic strains of Staphylococcus aureus, four of which were methicillin-resistant. Illumination of the photosensitisers at a fluence rate of 1.75 mW cm-2 generally resulted in the enhancement of antibacterial activity in liquid culture and in greater efficacy than the methicillin analogue flucloxacillin. For methylene blue, dimethyl methylene blue and new methylene blue illumination led to increases in bactericidal activity < or = 16-fold, typically 4-fold. In addition dimethyl methylene blue and new methylene blue were active against epidemic strains of methicillin-resistant Staphylococcus aureus at concentrations lower than that of vancomycin (> or = 0.5 microM).
The Arabidopsis Group 1 LATE EMBRYOGENESIS ABUNDANT Protein ATEM6 Is Required for Normal Seed Development (2005)

As part of the embryo maturation process, orthodox seeds undergo a developmentally regulated dehydration period. The LATE EMBRYOGENESIS ABUNDANT (LEA) genes encode a large and diverse family of proteins expressed during this time. Many hypothesize that LEA proteins act by mitigating water loss and maintaining cellular stability within the desiccated seed, although the mechanisms of their actions remain largely unknown. The model plant Arabidopsis (Arabidopsis thaliana) contains two genes belonging to the group 1 LEA family, ATEM1 and ATEM6, and knockout mutations in these genes are being sought as a means to better understand group 1 LEA protein function during embryo maturation. We have identified a T-DNA insertion allele of the ATEM6 gene in which the T-DNA is present just downstream of the protein coding region. While this gene is transcriptionally active and encodes a wild-type protein, there is no detectable ATEM6 protein in mature seeds. Mutant seeds display premature seed dehydration and maturation at the distal end of siliques, demonstrating that this protein is required for normal seed development. We propose that one function for group 1 LEA proteins in seed development is to buffer the water loss that occurs during embryo maturation and that loss of ATEM6 expression results in the mutant phenotype.
Pathobiology of autochthonous prostate cancer in a pre‐clinical transgenic mouse model (2003)

This study will serve as the basis for the rational design of pre-clinical studies with genetically engineered mouse models.
Activation of Opioid μ Receptors in Caudal Medullary Raphe Region Inhibits the Ventilatory Response to Hypercapnia in Anesthetized Rats (2007)

: These results lead to the conclusion that mu receptors in the caudal MRR rather than the middle MRR or rostral MRR are important but not exclusive for attenuating the hypercapnic ventilatory response.
Bdd-based logic synthesis system (2000)

Binary decision diagrams (BDDs) is the most efficient Boolean logic representation found so far. In this dissertation, a new BDD-based logic synthesis system is presented. The system is based on a new BDD decomposition theory which supports both algebraic and Boolean factorization. New techniques, which are crucial to the manipulation of BDDs in a partitioned Boolean network environment, are described in detail. The experimental results show that our logic synthesis system has a capability to handle very large circuits. It offers a superior run-time advantage over the state-of-the-art logic synthesis system, with comparable results in terms of circuit area and often improved delay.
Sterilization of Dental Instruments by Electrolyzed Water and Their Corrosion Behaviors (1997)

The excellent bactericidal activity of the electrolyzed acid water has recently been noticed in dentistry. The authors previously demonstrated the validity of the strong acid water as a disinfectant for impression showing rapid and reliable sterilization effect. In the present study, the applicability of the electrolyzed water to sterilization of dental metallic instruments was examined. The contamination bacteria tested were Streptococcus salivarius (IFO 13956). As the problem with the acid water is that it is potentially corrosive to metals, corrosion tests were also carried out. The instruments having simple configuration such as reamer and explorer could be sterilized by one-minute immersion in the strong acid water, while those of comlicated configuration such as diamond stones and burs required much longer time for equivalent sterilization. When the ultrasonic cleaning action was added in the strong acid water, all the instruments were sufficiently sterilized by one-minute treatment although such a cleaning itself could give little effect of removing bacteria from the instruments even by 20-minute treatment in distilled water. Another type of electrolized water, the week acid water 5.2 in pH showed almost the same effects as the strong acid water. The reamer and diamond stone showed no corrosion in 24-hour immersion in the acid water. The working end of the explorer was also sound while many corrosion pits were observed on its handle. A marked corrosion was found on the overall surface of the steel burs, and a localized loss occurred at the brazed area between the blade and shank of the carbide burs without the blade being harmed. It was confirmed that the week acid water was less corrosive than the strong. Significant damages of the burs by corrosion appeared after 3-hour immersion in the acid water. The term corresponds to 180-time repetitions of one-minute immersion treatment, indicating that such a corrosion behavior may not result in any practically serious problem because it may far exceed the mechanical lives in service of their blades. These findings suggest that both the electrolyzed strong and week acid waters may well be available as the disinfectant for dental instruments.
그림책『행복한 우리가족』에 나타난 현대 어머니상 탐구 (2013)

본 연구의 목적은 그림책『행복한 우리가족』에 나타나는 현대 어머니상을 탐구하는 것이다. 이를 위해 한성옥의 그림책『행복한 우리가족』을 분석대상으로 선정하여 분석하였다. 분석 결과, 현대의 어머니상은 크게 가정의 주도권을 쥔 어머니, 사회의 변화에만 약삭빠르게 대응하는 어머니, 가족 이기주의를 근간으로 체면과 타인의식을 무시하는 어머니, 규범과 규칙을 벗어나 아전인수(我田引水)격인 어머니 등의 네 가지 유형으로 분류해 볼 수 있었다. 이러한 결과를 바탕으로 본 연구에서는 각 유형별 어머니상에 대해 보다 구체적으로 살펴보면서 시대적, 사회적 변화의 와중에서도 본질적으로 변하지 않는 어머니 상의 측면은 무엇인지, 향후 어머니상은 어떻게 전개되어 나갈 것인지, 어머니상의 변화에 따라 부모교육 특히, 어머니 교육이 실시되어야 할 필요성은 어디에 있는지 등에 관해 논의하였다.
Dilation of the Human Immunodeficiency Virus–1 Envelope Glycoprotein Fusion Pore Revealed by the Inhibitory Action of a Synthetic Peptide from gp41 (1998)

We have monitored fusion between cell pairs consisting of a single human immunodeficiency virus-1 (HIV-1) envelope glycoprotein-expressing cell and a CD4+ target cell, which had been labeled with both a fluorescent lipid in the membrane and a fluorescent solute in the cytosol. We developed a new three-color assay to keep track of the cell into which fluorescent lipids and/or solutes are redistributed. Lipid and solute redistribution occur as a result of opening a lipid-permissive fusion pore and a solute-permissive fusion pore (FPS), respectively. A synthetic peptide (DP178) corresponding to residues 643-678 of the HIV-1LAI gp120-gp41 sequence (Wild, C.T., D.C. Shugars, T.K. Greenwell, C.B. McDanal, and T.J. Matthews. 1994. Proc. Natl. Acad. Sci. USA. 91:12676-12680) completely inhibited FPS at 50 ng/ml, whereas at that concentration there was 20-30% fusion activity measured by the lipid redistribution. The differences detected in lipid mixing versus contents mixing are maintained up to 6 h of coculture of gp120-41-expressing cells with target cells, indicating that DP178 can "clamp" the fusion complex in the lipid mixing intermediate for very long time periods. A peptide from the NH2-terminal of gp41, DP107, inhibited HIV-1LAI gp120-gp41-mediated cell fusion at higher concentrations, but with no differences between lipid and aqueous dye redistribution at the different inhibitor concentrations. The inhibition of solute redistribution by DP178 was complete when the peptide was added to the fusion reaction mixture during the first 15 min of coculture. We have analyzed the inhibition data in terms of a fusion pore dilation model that incorporates the recently determined high resolution structure of the gp41 core.
Ocular drug delivery systems: An overview (2013)

The major challenge faced by today's pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration, especially for the treatment of anterior segment diseases. Delivery of drugs to the targeted ocular tissues is restricted by various precorneal, dynamic and static ocular barriers. Also, therapeutic drug levels are not maintained for longer duration in target tissues. In the past two decades, ocular drug delivery research acceleratedly advanced towards developing a novel, safe and patient compliant formulation and drug delivery devices/techniques, which may surpass these barriers and maintain drug levels in tissues. Anterior segment drug delivery advances are witnessed by modulation of conventional topical solutions with permeation and viscosity enhancers. Also, it includes development of conventional topical formulations such as suspensions, emulsions and ointments. Various nanoformulations have also been introduced for anterior segment ocular drug delivery. On the other hand, for posterior ocular delivery, research has been immensely focused towards development of drug releasing devices and nanoformulations for treating chronic vitreoretinal diseases. These novel devices and/or formulations may help to surpass ocular barriers and associated side effects with conventional topical drops. Also, these novel devices and/or formulations are easy to formulate, no/negligibly irritating, possess high precorneal residence time, sustain the drug release, and enhance ocular bioavailability of therapeutics. An update of current research advancement in ocular drug delivery necessitates and helps drug delivery scientists to modulate their think process and develop novel and safe drug delivery strategies. Current review intends to summarize the existing conventional formulations for ocular delivery and their advancements followed by current nanotechnology based formulation developments. Also, recent developments with other ocular drug delivery strategies employing <i>in situ</i> gels, implants, contact lens and microneedles have been discussed.