gebhart/patrepeval huggingface dataset:
A Two-Step Thermochemical Water Splitting by Iron-Oxide on Stabilized Zirconia (2004)

The thermochemical two-step water splitting cycle was examined by using an iron oxide supported on yttrium-stabilized, cubic zirconia (YSZ) as the working material with a view toward direct conversion of solar high-temperature heat to clean hydrogen energy. In the first step of the cycle, the YSZ-supported Fe3O4 was thermally decomposed to the reduced phase at 1400°C under an inert atmosphere. The reduced solid phase was oxidized back to the original phase (the YSZ-supported Fe3O4) with steam to generate hydrogen below 1000°C. A new redox pair, which is different from the Fe3O4-FeO pair previously examined by others, served as the working solid material on this YSZ-supported Fe3O4. Our new redox reaction proceeded as follows. The Fe3O4 reacted with YSZ to produce an Fe2+-containing ZrO2 phase by releasing oxygen molecules in the first step: The Fe2+ ions entered into the cubic YSZ lattice. In the second step, the Fe2+-containing YSZ generated hydrogen via steam splitting to reproduce Fe3O4 on the cubic YSZ support. This cyclic reaction could be repeated with a good repeatability of the reaction below 1400°C.
Concentration of IL‐2, IL‐6, IL‐8, IL‐10 and TNF‐alpha in children with acute lymphoblastic leukemia after cessation of chemotherapy (2004)

The immunosuppressive effect of cytotoxic drugs, basic therapeutic agents in the treatment of childhood acute leukemias, requires monitoring of the immune system following cessation of therapy. The cytokines are soluble proteins that play a key role in the immunoregulation of the lymphocyte function. The cytokines regulate growth, differentiation and function of various cells in normal conditions. The aim of our study was to estimate serum levels of IL-2, IL-6, IL-8, IL-10 and TNF-alpha in children with acute lymphoblastic leukemia (ALL) after cessation of chemotherapy. The study involved 150 children with ALL. This group consisted of: 30 children 1 month after treatment cessation; 30 children, 3 months later; 30 children 6 months later; 30 children, 9 months later and 30 children, 12 months later. The control group consisted of 30 healthy children. The levels of the cytokines under study were assayed using the immunoassay kits (R&D Systems, USA). During the study significant differences in TNF-alpha, IL-2 and IL-8 serum concentrations were observed among treated children and controls. However there were no differences in IL-6 and IL-10 concentrations.
IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes (2004)

IMGT/GENE-DB is the comprehensive IMGT genome database for immunoglobulin (IG) and T cell receptor (TR) genes from human and mouse, and, in development, from other vertebrates. IMGT/GENE-DB is the international reference for the IG and TR gene nomenclature and works in close collaboration with the HUGO Nomenclature Committee, Mouse Genome Database and genome committees for other species. IMGT/GENE-DB allows a search of IG and TR genes by locus, group and subgroup, which are CLASSIFICATION concepts of IMGT-ONTOLOGY. Short cuts allow the retrieval gene information by gene name or clone name. Direct links with configurable URL give access to information usable by humans or programs. An IMGT/GENE-DB entry displays accurate gene data related to genome (gene localization), allelic polymorphisms (number of alleles, IMGT reference sequences, functionality, etc.) gene expression (known cDNAs), proteins and structures (Protein displays, IMGT Colliers de Perles). It provides internal links to the IMGT sequence databases and to the IMGT Repertoire Web resources, and external links to genome and generalist sequence databases. IMGT/GENE-DB manages the IMGT reference directory used by the IMGT tools for IG and TR gene and allele comparison and assignment, and by the IMGT databases for gene data annotation. IMGT/GENE-DB is freely available at http://imgt.cines.fr.
Hardware accelerated convolutional neural networks for synthetic vision systems (2010)

In this paper we present a scalable hardware architecture to implement large-scale convolutional neural networks and state-of-the-art multi-layered artificial vision systems. This system is fully digital and is a modular vision engine with the goal of performing real-time detection, recognition and segmentation of mega-pixel images. We present a performance comparison between a software, FPGA and ASIC implementation that shows a speed up in custom hardware implementations.
Association of insulin receptor substrate-1 with integrins (1994)

Insulin stimulation was found to promote association of the alpha v beta 3 integrin (a vitronectin receptor) with insulin receptor substrate-1 (IRS-1), an intracellular protein that mediates insulin signaling by binding other signaling molecules, including growth factor receptor-bound protein 2 (Grb2) and phosphatidylinositol-3' kinase. Insulin-treated cells expressing the alpha v beta 3 integrin showed 2.5 times more DNA synthesis when plated on vitronectin than on other substrates, whereas cells expressing another vitronectin receptor, alpha v beta 5, did not show this difference. The association between integrin and IRS-1 may be a mechanism for the synergistic action of growth factor and extracellular matrix receptors.
Imaging Flow Cytometry (2012)

Imaging flow cytometry (IFC) platforms combine features of flow cytometry and fluorescent microscopy with advances in data-processing algorithms. IFC allows multiparametric fluorescent and morphological analysis of thousands of cellular events and has the unique capability of identifying collected events by their real images. IFC allows the analysis of heterogeneous cell populations, where one of the cellular components has low expression (<0.03%) and can be described by Poisson distribution. With the help of IFC, one can address a critical question of statistical analysis of subcellular distribution of proteins in a cell. Here the authors review advantages of IFC in comparison with more traditional technologies, such as Western blotting and flow cytometry (FC), as well as new high-throughput fluorescent microscopy (HTFM), and discuss further developments of this novel analytical technique.
Synthesis and insecticidal activity of benzoheterocyclic analogues of N′‐benzoyl‐N‐(tert‐butyl)benzohydrazide: Part 2. Introduction of substituents on the benzene rings of the benzoheterocycle moiety (2002)

A series of N'-benzoheterocyclecarbonyl-N-tert-butyl-3,5-dimethylbenzohydrazide analogues possessing a variety of substituents on the benzene rings of the benzoheterocyle moieties were synthesized and tested for their insecticidal activity. The introduction of a methyl group at the R1 position of the benzoheterocycle moiety strongly increased the insecticidal activity. Among the analogues synthesized, N'-tert-butyl-N'-(3,5-dimethylbenzoyl)-5-methyl-6-chromanecarbohydrazide showed the highest insecticidal activity (LC50 = 0.89 mg litre(-1)).
Application of Lateral Photovoltaic Effect to the Measurement of the Physical Quantities ofP-NJunctions–Sheet Resistivity and Junction Conductance of N2+Implanted Si (1976)

A new method of measuring the physical quantities of a thin film p-n junction such as the one formed by ion implantation has been developed; by means of this method difficulties of making reliable electrical contacts with thin layers and leakage currents which are often encountered when applying the bias voltage can be avoided. Lucovsky's theory for the lateral photovoltaic effect has been extended such that nonzero values for sheet resistivities of both p and n layers and a finite value for the length of the junction are taken into consideration, and the modified theory has been experimentally verified using p-Si samples implanted with N2+ at 8 keV. With the aid of the theory, sheet resistivities, junction conductances and some other physical quantities are obtained by analysing the measured lateral photovoltage (LPV). The use of the LPV method together with the ordinary one increases the reliability of the measurement.
Use of Electrospinning to Directly Fabricate Hollow Nanofibers with Functionalized Inner and Outer Surfaces (2004)

Within or without: With the use of a coaxial, dual-capillary spinneret, electrospinning has been demonstrated as a versatile tool to fabricate hollow nanofibers with either their outer or inner surfaces being functionalized by molecular species or nanoparticles (the pictures show schematic cross sections of the functionalized hollow nanofibers).
Amino Acid Sequence of Human λ Chains (1970)

Abstract For determination of the amino acid sequence of the human λ Bence-Jones Protein Ha, the protein was reduced and aminoethylated and digested with trypsin. Twenty-two tryptic peptides were isolated by chromatography. The complete sequence was determined for 11 peptides including all but one of those comprising the variable NH2-terminal half of the protein. The remaining peptides were subjected only to amino acid and end group analysis. Altogether, the the position of 119 out of the 217 residues in the protein was determined. None of the tryptic peptides in the NH2-terminal half of the molecule was identical in sequence with those reported for other human λ chains, whereas all of the tryptic peptides covering the sequence from position 109 through the COOH terminus corresponded exactly to the sequence earlier reported for the constant part of human λ chains.
INDIVIDUAL TRANSPARENCY PATTERNS OF ADHESIVE‐TAPE STRIP SERIES OF THE STRATUM CORNEUM (1977)

A newly developed apparatus permits the differentiated transparency measurement of stripped horny layer material. An adhesive tape strip, covered with a stripped horny layer mass, is fixed on a glass plate and led past a homogenous light source and a photo cell at a constant speed, whereby each respective light-current deviation is collected as a parameter for each respective strip model. It is then synchronously registered via a continuous-line-recorder. The systematic evaluation of original curves results in a reproducible individual horny layer model obtained by a methodically stripped adhesive tape series, successively taken under constant conditions from the same skin area. Three characteristic types of curves were observed.
Relationships Between Mycoplasma pneumoniae and Human Respiratory Epithelium (1971)

The interaction was studied between Mycoplasma pneumoniae and its natural host cell, the human respiratory epithelium. Organized, ciliated cells provided by fetal trachea in organ culture enabled examination of the host-parasite relationship by light, immunofluorescence, and electron microscopy. Impairment of cellular function was reflected by disorganization and loss of ciliary motion; this was associated with a sequence of cytopathological changes denoting progressive cell injury. The organisms were found concentrated on the luminal surface of ciliated epithelium and cells lining the submucosal glands. A differentiated portion of the Mycoplasma, consisting of an extension of the unit membrane containing an electron-dense core surrounded by a lucent space, served as the means of attachment to host cells. The findings suggest that the pathogenicity of M. pneumoniae depends upon intimate extracellular infection with production of functional and structural changes initiated by host cell membrane injury.
Transforming Growth Factor-β1 Mutations in Camurati-Engelmann Disease Lead to Increased Signaling by Altering either Activation or Secretion of the Mutant Protein (2003)

Transforming growth factor-beta1 (TGF-beta1) is secreted as a latent precursor, consisting of a homodimer of the latency-associated peptide and the mature peptide. TGFbeta-1 can only exert its many functions after going from this latent to an active state, in which the binding site of the mature peptide for its receptor is no longer shielded by the latency-associated peptide. We and others reported that mutations in TGFB1 cause Camurati-Engelmann disease, a rare bone disorder. Until now, seven mutations have been published. In this study, we investigate the effect of the LLL12-13ins, Y81H, R218C, H222D, and C225R mutations on the functioning of TGF-beta1 in vitro. A luciferase reporter assay specific for TGF-beta-induced transcriptional response with wild type and mutant TGF-beta1 constructs showed a positive effect of all mutations on TGF-beta1 activity. By way of enzyme-linked immunosorbent assay, we found that in the R218C, H222D, and C225R mutant constructs, this effect is caused by an increase in active TGF-beta1 in the medium of transfected cells. The LLL12-13ins and Y81H mutations on the contrary have a profound effect on secretion; a decreased amount of TGF-beta1 is secreted, but the increased luciferase activity shows that the intracellular accumulation of (aberrant) TGF-beta1 can initiate an enhanced transcriptional response, suggesting the existence of an alternative signaling pathway. Our data indicate that the mutations in the signal peptide and latency-associated peptide facilitate TGF-beta1 signaling, thus causing Camurati-Engelmann disease.
Infection in transplantation: advances and unmet needs (2000)

Transplantation Infectious Diseases, Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA Correspondence to Jay A. Fishman, MD, Infectious Disease Division, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA; e-mail: [email protected]
Tri- and tetranuclear RuII–GdIII2 and RuII–GdIII3 d–f heterometallic complexes as potential bimodal imaging probes for MRI and optical imaging (2016)

Tri- and tetranuclear Ru<sup>II</sup>–GdII2 and Ru<sup>II</sup>–GdIII3 d–f heterometallic complexes, which function as contrast agents for MRI and as optical probes for fluorescence imaging, are reported. <italic>In vitro</italic> studies using the HeLa cell lines show that these complexes exhibit anticancer activity.
Narrowband impedance matching layer for high efficiency thickness mode ultrasonic transducers (2002)

A new matching layer design concept has been proposed for narrowband continuous wave (CW) devices. Analysis has shown that the mechanical impedance of a resonant-type transducer in thickness mode CW operation does not equal its acoustic impedance rhoVs but roughly equals rhoVs/Q, where p is density, Vs is acoustic velocity, and Q is the mechanical quality factor. The value of rhoVs/Q is much lower than the acoustic impedance of water for any transducer material, including lead zirconium titanate (PZT), single crystals, or polyvinylidene fluoride (PVDF). With this new approach, the impedance of the matching layer must also be between water and pVs/Q, but there are few such practical low impedance materials. To realize equivalent low impedance structure, a novel double layer design is presented: a relatively low impedance material (such as polyethylene or polyurethane) on the inside and a relatively high impedance material (such as polyester or metal) on the outside. A high power CW transducer structure was designed and fabricated with PVDF-TrFE (polyvinylidene fluoride trifluoroethylene) to operate at 1.4 MHz. The basic quarter wavelength resonator structure is 0.7-mm alumina/0.2-mm piezo-polymer/0.25-mm polyester, and the matching section is 0.2-mm polyurethane and 0.25-mm polyester. A maximum power output of 6 to 9 W/cm2 with conversion efficiency of 30 to 35% was observed. For the transducer without matching section, the observed power was 3 to 4 W/cm2. Mason's model analyses (1) predict that the traditional matching layer is for broadband purposes and reduces output power both for PZT and PVDF-TrFE (2); this new matching scheme can be applied to PZT high power transducer. This high efficiency technique has application in various CW systems, such as Doppler sensors, interferometry, phase-sensitive imaging, or high energy focused beam systems.
Failure of naloxone to prevent the emetic activity of apomorphine in dogs (1981)

Apomorphine is derived from morphine by acid hydrolysis (DiChiara &amp; Gessa, 1978), and for many years has been used in both human and veterinary medicine as an effective agent for induction of emesis, primarily in cases of poisoning. Since apomorphine is derived from morphine, it was initially thought that it was an opiate receptor agonist similar to morphine. As a result, several medical and veterinary medical pharmacology textbooks recommend reversal of the emetic activity of apomorphine hydrochloride by administration of naloxone hydrochloride, a narcotic antagonist (Klaassen, 1980; Meyers, Jawetz &amp; Goldfien, 1980).
Polyphasic taxonomy of the heat resistant ascomycete genus Byssochlamys and its Paecilomyces anamorphs (2009)

Byssochlamys and related Paecilomyces strains are often heat resistant and may produce mycotoxins in contaminated pasteurised foodstuffs. A comparative study of all Byssochlamys species was carried out using a polyphasic approach to find characters that differentiate species and to establish accurate data on potential mycotoxin production by each species. Phylogenetic analysis of the ITS region, parts of the beta-tubulin and calmodulin genes, macro- and micromorphological examinations and analysis of extrolite profiles were applied. Phylogenetic analyses revealed that the genus Byssochlamys includes nine species, five of which form a teleomorph, i.e. B. fulva, B. lagunculariae, B. nivea, B. spectabilis and B. zollerniae, while four are asexual, namely P. brunneolus, P. divaricatus, P. formosus and P. saturatus. Among these, B. nivea produces the mycotoxins patulin and byssochlamic acid and the immunosuppressant mycophenolic acid. Byssochlamys lagunculariae produces byssochlamic acid and mycophenolic acid and thus chemically resembles B. nivea. Some strains of P. saturatus produce patulin and brefeldin A, while B. spectabilis (anamorph P. variotii s.s.) produces viriditoxin. Some micro- and macromorphological characters are valuable for identification purposes, including the shape and size of conidia and ascospores, presence and ornamentation of chlamydospores, growth rates on MEA and CYA and acid production on CREA. A dichotomous key is provided for species identification based on phenotypical characters.
Vancomycin analogues active against vanA-resistant strains inhibit bacterial transglycosylase without binding substrate (2003)

Bacterial transglycosylases are enzymes that couple the disaccharide subunits of peptidoglycan to form long carbohydrate chains. These enzymes are the target of the pentasaccharide antibiotic moenomycin as well as the proposed target of certain glycopeptides that overcome vancomycin resistance. Because bacterial transglycosylases are difficult enzymes to study, it has not previously been possible to evaluate how moenomycin inhibits them or to determine whether glycopeptide analogues directly target them. We have identified transglycosylase assay conditions that enable kinetic analysis of inhibitors and have examined the inhibition of Escherichia coli penicillin-binding protein 1b (PBP1b) by moenomycin as well as by various glycopeptides. We report that chlorobiphenyl vancomycin analogues that are incapable of binding substrates nevertheless inhibit E. coli PBP1b, which shows that these compounds interact directly with the enzyme. These findings support the hypothesis that chlorobiphenyl vancomycin derivatives overcome vanA resistance by targeting bacterial transglycosylases. We have also found that moenomycin is not competitive with respect to the lipid II substrate of PBP1b, as has long been believed. With the development of suitable methods to evaluate bacterial transglycosylases, it is now possible to probe the mechanism of action of some potentially very important antibiotics.
Gene therapy prevents photoreceptor death and preserves retinal function in a Bardet-Biedl syndrome mouse model (2011)

Patients with Bardet-Biedl syndrome (BBS) experience severe retinal degeneration as a result of impaired photoreceptor transport processes that are not yet fully understood. To date, there is no effective treatment for BBS-associated retinal degeneration, and blindness is imminent by the second decade of life. Here we report the development of an adeno-associated viral (AAV) vector that rescues rhodopsin mislocalization, maintains nearly normal-appearing rod outer segments, and prevents photoreceptor death in the Bbs4-null mouse model. Analysis of the electroretinogram a-wave indicates that rescued rod cells are functionally indistinguishable from wild-type rods. These results demonstrate that gene therapy can prevent retinal degeneration in a mammalian BBS model.
Structure and Function of the Polymeric Mucins in Airways Mucus (2007)

The airways mucus gel performs a critical function in defending the respiratory tract against pathogenic and environmental challenges. In normal physiology, the secreted mucins, in particular the polymeric mucins MUC5AC and MUC5B, provide the organizing framework of the airways mucus gel and are major contributors to its rheological properties. However, overproduction of mucins is an important factor in the morbidity and mortality of chronic airways disease (e.g., asthma, cystic fibrosis, and chronic obstructive pulmonary disease). The roles of these enormous, multifunctional, O-linked glycoproteins in health and disease are discussed.
Multicarrier orthogonal CDMA signals for quasi-synchronous communication systems (1994)

Proposes a multicarrier orthogonal CDMA signaling scheme for a multiple-access communication system, such as the reverse channel of a cellular network, as an alternative to the multi-user interference cancellation approach. The average variance of cross-correlations between sequences is used as a measure for sequence design. The authors search for sets of sequences that minimize the probability of symbol detection error, given that there is imperfect synchronization among the signals, that is, the signals are quasi-synchronous. Orthogonal sequences based on the Sylvester-type Hadamard matrices (Walsh functions) are shown to provide a significant improvement over the case where a Hadamard (orthogonal) matrix is chosen at random. Computer searches suggest that this set of codes is optimal with respect to the above measure. The issue of chip pulse shaping is investigated. Optimal pulses designed to minimize multiple-access interference in quasi-synchronous systems are obtained for various bandwidths and are shown to provide a large improvement over the raised cosine pulses. A multicarrier signaling scheme is introduced in order to reduce chip level synchronization offsets between the users.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Mechanisms of Endothelial to Mesenchymal Transition in the Retina in Diabetes (2014)

These data indicate glucose-induced EndMT in vitro and in vivo is possibly mediated through TGFβ and regulated by miR-200b and p300.