gebhart/patrepeval huggingface dataset:
Hepatic denervation does not significantly change the response of the liver to glucagon in conscious dogs (1995)

In view of the increasing frequency of liver transplantation, and the importance of glucagon in the minute-to-minute regulation of glucose production, we assessed the effect of hepatic denervation on the liver's response to a physiological rise in glucagon in 18-h fasted dogs. Before study (2 wk), the dogs underwent liver denervation (DN; n = 6) or sham operation (SH; n = 5). Endogenous insulin and glucagon secretion were inhibited using somatostatin, and the two hormones were replaced intraportally in basal amounts. After the control period the glucagon infusion rate was tripled for 3 h. Glucagon increased from 41 +/- 8 to 128 +/- 8 and 54 +/- 4 to 129 +/- 9 pg/ml in SH and DN, respectively (P < 0.05), causing tracer-determined glucose production to increase from 2.5 +/- 0.1 to 4.9 +/- 0.5 and 2.3 +/- 0.1 to 5.8 +/- 0.8 mg.kg-1.min-1 by 15 min, respectively (P < 0.05). Glucose clearance fell slightly during glucagon infusion in DN, causing a somewhat greater increase in the plasma glucose level (to 175 +/- 15 vs. 207 +/- 20 mg/dl). The changes in gluconeogenic efficiency increased 65-90% in both groups (P < 0.05). In conclusion, denervation of the liver failed to significantly alter the metabolic response of that organ to a half-maximally effective increment in the plasma glucagon level.
Direct Copper Plating on Ultra-Thin Sputtered Cobalt Film in an Alkaline Bath (2013)

We report on the electrochemical process and nucleation mechanism of the "direct-on-barrier" electroplating of copper on ultrathin cobalt adhesion layer from an alkaline CuSO4 and ethylenediamine (En) bath without additives. Results show that the corrosion current density was much lower in the alkaline bath than that in the commercial acidic bath due to formation of the CuEn22+ species in the aqueous CuSO4-En solution. The CuEn22+ species can well stop the reaction between the copper ions and Co by reducing the potential of copper ions. The current-time transients were not typical of a diffusion-limited nucleation and growth. Pure instantaneous or progressive nucleation of copper on Co layer was not observed. The impact of current density on the orientation, resistance and morphology was studied. Copper film in 250 nm thick was successfully deposited on the 10 nm Co film in the patterned wafers. And Cu was electroplated onto ultrathin Co layer with ∼5 nm thickness and TEM result shows that there is no obvious Co thickness loss.
In vivo activities of cytokine oncostatin M in the regulation of plasma lipid levels (2005)

Our previous studies have demonstrated the activity of oncostatin M (OM) in stimulating the transcription of the human LDL receptor (LDLR) gene in HepG2 cells through a sterol-independent regulatory mechanism. The current studies were designed to determine whether this in vitro property of OM could be recapitulated in vivo to increase LDLR expression in cholesterol-loaded livers and consequently decrease plasma levels of LDL-cholesterol (LDL-C) and total cholesterol (TC) using hypercholesterolemic hamsters as an experimental model. We show that administration of human recombinant OM for 7 days in hamsters fed a high-fat diet significantly reduced plasma levels of TC, LDL-C, and triglyceride in dose- and time-dependent manners. This lipid-lowering effect was associated with increased hepatic LDLR mRNA expression, as determined by quantitative real-time RT-PCR. Additionally, hepatic fat storage and cholesterol content in the hypercholesterolemic animals were substantially reduced by OM treatment. As a consequence, the increased aminotransferase levels in the high-fat diet-fed hamsters were normalized nearly to baseline values. These results not only corroborate the in vitro finding of OM in the regulation of LDLR but also, for the first time, demonstrate that OM has a strong lipid-lowering effect under in vivo conditions in which the levels of circulating LDL-C are high and liver LDLR transcription is repressed.
AP-1 subunits: quarrel and harmony among siblings (2004)

The AP-1 transcription factor is mainly composed of Jun, Fos and ATF protein dimers. It mediates gene regulation in response to a plethora of physiological and pathological stimuli, including cytokines, growth factors, stress signals, bacterial and viral infections, as well as oncogenic stimuli. Studies in genetically modified mice and cells have highlighted a crucial role for AP-1 in a variety of cellular events involved in normal development or neoplastic transformation causing cancer. However, emerging evidence indicates that the contribution of AP-1 to determination of cell fates critically depends on the relative abundance of AP-1 subunits, the composition of AP-1 dimers, the quality of stimulus, the cell type and the cellular environment. Therefore, AP-1-mediated regulation of processes such as proliferation, differentiation, apoptosis and transformation should be considered within the context of a complex dynamic network of signalling pathways and other nuclear factors that respond simultaneously.
High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis # (2008)

The liver expresses FGF19 under conditions of extrahepatic cholestasis. This is accompanied by a number of adaptations aimed at protecting the liver against bile salt toxicity. FGF19 signaling may be involved in some of these adaptations.
Color Centers in Alkali-Silicate Glasses Containing Alkaline Earth Ions (1956)

Samples of alkali metal oxide-silica glasses with various kinds and amounts of alkaline earth oxide calcium oxide and silica were prepared, x-irradiated, and studied by spectrophotometry. Bleaching experiments with visible light were carried out. No effect of alkaline earth content upon the absorption spectra was detected.Room temperature bleaching of a ${\mathrm{K}}_{2}$O-SrO-Si${\mathrm{O}}_{2}$ glass with light of wavelength corresponding to the x-ray induced absorption band at 1.95 ev, decreased absorption generally but failed to create a new absorption band such as the ${Z}_{1}$ band found in KCl, containing Sr${\mathrm{Cl}}_{2}$, that has been irradiated and then bleached.Comparisons are made with alkali-halide systems containing alkaline earth halides. It is suggested that there are inadequacies in the quasi-crystalline model of glass when applied to these glasses.
Making a case for distributed file systems at Exascale (2011)

Exascale computers will enable the unraveling of significant scientific mysteries. Predictions are that 2019 will be the year of exascale, with millions of compute nodes and billions of threads of execution. The current architecture of high-end computing systems is decades-old and has persisted as we scaled from gigascales to petascales. In this architecture, storage is completely segregated from the compute resources and are connected via a network interconnect. This approach will not scale several orders of magnitude in terms of concurrency and throughput, and will thus prevent the move from petascale to exascale. At exascale, basic functionality at high concurrency levels will suffer poor performance, and combined with system mean-time-to-failure in hours, will lead to a performance collapse for large-scale heroic applications. Storage has the potential to be the Achilles heel of exascale systems. We propose that future high-end computing systems be designed with non-volatile memory on every compute node, allowing every compute node to actively participate in the metadata and data management and leveraging many-core processors high bisection bandwidth in torus networks. This position paper discusses this revolutionary new distributed storage architecture that will make exascale computing more tractable, touching virtually all disciplines in high-end computing and fueling scientific discovery.
LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer (2009)

The genetic basis for the hereditary leiomyomatosis and renal cell cancer syndrome is germ-line inactivating mutation in the gene for the Krebs/tricarboxylic acid cycle enzyme, fumarate hydratase (FH), the enzyme that converts fumarate to malate. These individuals are predisposed to development of leiomyomas of the skin and uterus as well as highly aggressive kidney cancers. Inhibition of FH should result in significant decrease in oxidative phosphorylation necessitating that glycolysis followed by fermentation of pyruvate to lactate will be required to provide adequate ATP as well as to regenerate NAD+. Moreover, FH deficiency is known to up-regulate expression of hypoxia-inducible factor (HIF)-1alpha by enhancing the stability of HIF transcript. This leads to activation of various HIF-regulated genes including vascular endothelial growth factor and glucose transporter GLUT1 and increased expression of several glycolytic enzymes. Because lactate dehydrogenase-A (LDH-A), also a HIF-1alpha target, promotes fermentative glycolysis (conversion of pyruvate to lactate), a step essential for regenerating NAD+, we asked whether FH-deficient cells would be exquisitely sensitive to LDH-A blockade. Here, we report that hereditary leiomyomatosis and renal cell cancer tumors indeed overexpress LDH-A, that LDH-A inhibition results in increased apoptosis in a cell with FH deficiency and that this effect is reactive oxygen species mediated, and that LDH-A knockdown in the background of FH knockdown results in significant reduction in tumor growth in a xenograft mouse model.
Point mutations in the S protein connect the sialic acid binding activity with the enteropathogenicity of transmissible gastroenteritis coronavirus (1997)

Enteropathogenic transmissible gastroenteritis virus (TGEV), a porcine coronavirus, is able to agglutinate erythrocytes because of sialic acid binding activity. Competitive inhibitors that may mask the sialic acid binding activity can be inactivated by sialidase treatment of virions. Here, we show that TGEV virions with efficient hemagglutinating activity were also obtained when cells were treated with sialidase prior to infection. This method was used to analyze TGEV mutants for hemagglutinating activity. Recently, mutants with strongly reduced enteropathogenicity that have point mutations or a deletion of four amino acids within residues 145 to 155 of the S protein have been described. Here, we show that in addition to their reduced pathogenicity, these mutants also have lost hemagglutinating activity. These results connect sialic acid binding activity with the enteropathogenicity of TGEV.
Group B Streptococcus -hemolysin/Cytolysin Breaches Maternal-Fetal Barriers to Cause Preterm Birth and Intrauterine Fetal Demise in Vivo (2014)

Preterm birth and fetal demise are likely the direct result of toxin-induced damage and inflammation rather than differences in efficiency of ascension into the upper genital tract. These data demonstrate a distinct contribution of βH/C to GBS chorioamnionitis and subsequent fetal infection in vivo and showcase a model for this most proximal step in GBS pathogenesis.
Polar Quantizer for Wireless Receivers: Theory, Analysis, and CMOS Implementation (2013)

This paper presents the theory and analysis of IF polar receiver (PRX) architecture. By using new quantization techniques in the polar domain, the proposed receiver can boost the signal to quantization noise ratio (SQNR) compared to a traditional rectangular (I/Q) receiver. The proposed PRX is composed of a magnitude and a phase quantizer. The magnitude quantizer is similar to the conventional rectangular quantizer in voltage domain. The phase quantizer employs a time-to-digital converter (TDC) for phase detection. Furthermore, an intuitive graphical method is used to analyze the quantization properties of the polar quantization. A 10 bit polar quantizer is designed and fabricated in 130 nm CMOS, and achieves 2- to 5-dB of SQNR improvement compared to rectangular quantizer for signal bandwidths as high as 20 MHz.
In situ growth of interdigitated electrodes made of polypyrrole for active fiber composites (2007)

Abstract Active fiber composites are electromechanical actuators based on piezo‐ceramic fibers, which are embedded in a polymer matrix. The fibers are electrically contacted through so‐called interdigitated electrodes (IDEs). State‐of‐the‐art metallic IDEs only contact the fibers at two small sections of their circumference at the top and bottom of the composite ply, respectively. This paper presents an original technique to manufacture IDEs made of a conducting polymer (polypyrrole/ p ‐toluene sulfonic acid), where the polymer electrodes contact the fibers around their whole circumference. The necessary process steps are discussed, namely design of the master electrodes and electrochemical polymer growth with and without fibers. Processing issues are discussed and solutions are suggested. Copyright © 2007 John Wiley &amp; Sons, Ltd.
Selective Controllability: A Proposal for Testing and Diagnosis (1978)

This paper proposes a testing and diagnostic method that reduces fault location and repair costs on printed circuit boards populated with LSI and VLSI modules. The method requires some additional circuitry on the module subassembly. It enhances the following test strategies: automatic probing, bed-of-nails, Subassembly-in-Place, and Level Sensitive to Scan Design (LSSD). In addition, this technique makes it possible to partition large networks into manageable subnetworks for Automatic Test Generation.
Influence of pH on the Photochemical and Electrochemical Reduction of the Dinuclear Ruthenium Complex, [(phen)2Ru(tatpp)Ru(phen)2]Cl4, in Water: Proton‐Coupled Sequential and Concerted Multi‐Electron Reduction (2005)

The dinuclear ruthenium complex [(phen)2Ru(tatpp)Ru(phen)2]4+ (P; in which phen is 1,10-phenanthroline and tatpp is 9,11,20,22-tetraaza tetrapyrido[3,2-a:2'3'-c:3'',2''-l:2''',3''']-pentacene) undergoes a photodriven two-electron reduction in aqueous solution, thus storing light energy as chemical potential within its structure. The mechanism of this reduction is strongly influenced by the pH, in that basic conditions favor a sequential process involving two one-electron reductions and neutral or slightly acidic conditions favor a proton-coupled, bielectronic process. In this complex, the central tatpp ligand is the site of electron storage and protonation of the central aza nitrogen atoms in the reduced products is observed as a function of the solution pH. The reduction mechanism and characterization of the rich array of products were determined by using a combination of cyclic and AC voltammetry along with UV-visible reflectance spectroelectrochemistry experiments. Both the reduction and protonation state of P could be followed as a function of pH and potential. From these data, estimates of the various reduced species' pKa values were obtained and the mechanism to form the doubly reduced, doubly protonated complex, [(phen)2Ru(H2tatpp)Ru(phen)2]4+ (H2P) at low pH (< or =7) could be shown to be a two-proton, two-electron process. Importantly, H2P is also formed in the photochemical reaction with sacrificial reducing agents, albeit at reduced yields relative to those at higher pH.
Data-Based Quadrature Imbalance Compensation for a CW Doppler Radar System (2013)

A method for quadrature imbalance compensation in direct-conversion quadrature Doppler radar systems, based on data obtained using a mechanical target and an ellipse fit method, is reported. The proposed method can be used with different architectures of Doppler radar and eliminates the need to modify the radar in order to perform imbalance measurements. A mechanical target was used to provide sufficient motion to create a significant segment of an ellipse in the in-phase/quadrature trace to obtain correction factors with high accuracy. Parametric simulations were performed to analyze the accuracy of this technique in the presence of varying noise and target displacements. This method is compared with an existing phase-shifter-based imbalance computation technique for the measurement of known displacements and is shown to give consistent and more accurate results. Experimental data, consistent with simulations, demonstrates that accurate correction is obtained with 65% of the ellipse, resulting in a displacement error of less than 6%.
IX. On the problem of the most efficient tests of statistical hypotheses (1933)

Abstract The problem of testing statistical hypotheses is an old one. Its origin is usually connected with the name of Thomas Bayes, who gave the well-known theorem on the probabilities a posteriori of the possible “causes“ of a given event. Since then it has been discussed by many writers of whom we shall here mention two only, Bertrand and Borel, whose differing views serve well to illustrate the point from which we shall approach the subject. Bertrand put into statistical form a variety of hypotheses, as for example the hypothesis that a given group of stars with relatively small angular distances between them as seen from the earth, form a “system” or group in space. His method of attack, which is that in common use, consisted essentially in calculating the probability, P, that a certain character, x, of the observed facts would arise if the hypothesis tested were true. If P were very small, this would generally be considered as an indication that the hypothesis, H, was probably false, and vice versa. Bertrand expressed the pessimistic view that no test of this kind could give reliable results. Borel, however, in a later discussion, considered that the method described could be applied with success provided that the character, x, of the observed facts were properly chosen—were, in fact, a character which he terms “en quelque sorte remarquable.”
Palladium‐Catalyzed Selective Anti‐Markovnikov Oxidation of Allylic Esters (2013)

An aldol alternative: The palladium(II)-catalyzed anti-Markovnikov oxidation of allylic esters to aldehydes at room temperature provides a viable alternative to valuable cross aldol products. High regioselectivity towards the aldehyde product was achieved using the ester protecting group for the allylic alcohol. Rapid isomerization and the much higher rate of oxidation of the branched isomer result in the same product forming from both linear and branched allylic esters. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
An Efficient Fault-Tolerant Routing Methodology for Meshes and Tori (2004)

In this paper we present a methodology to design fault-tolerant routing algorithms for regular direct interconnection networks. It supports fully adaptive routing, does not degrade performance in the absence of faults, and supports a reasonably large number of faults without significantly degrading performance. The methodology is mainly based on the selection of an intermediate node (if needed) for each source-destination pair. Packets are adaptively routed to the intermediate node and, at this node, without being ejected, they are adaptively forwarded to their destinations. In order to allow deadlock-free minimal adaptive routing, the methodology requires only one additional virtual channel (for a total of three), even for tori. Evaluation results for a 4 x 4 x 4 torus network show that the methodology is 5-fault tolerant. Indeed, for up to 14 link failures, the percentage of fault combinations supported is higher than 99.96%. Additionally, network throughput degrades by less than 10% when injecting three random link faults without disabling any node. In contrast, a mechanism similar to the one proposed in the BlueGene/L, that disables some network planes, would strongly degrade network throughput by 79%.
Oxidative Stress in Pancreatic Beta Cell Regeneration (2017)

Pancreatic <i>β</i> cell neogenesis and proliferation during the neonatal period are critical for the generation of sufficient pancreatic <i>β</i> cell mass/reserve and have a profound impact on long-term protection against type 2 diabetes (T2D). Oxidative stress plays an important role in <i>β</i> cell neogenesis, proliferation, and survival under both physiological and pathophysiological conditions. Pancreatic <i>β</i> cells are extremely susceptible to oxidative stress due to a high endogenous production of reactive oxygen species (ROS) and a low expression of antioxidative enzymes. In this review, we summarize studies describing the critical roles and the mechanisms of how oxidative stress impacts <i>β</i> cell neogenesis and proliferation. In addition, the effects of antioxidant supplements on reduction of oxidative stress and increase of <i>β</i> cell proliferation are discussed. Exploring the roles and the potential therapeutic effects of antioxidants in the process of <i>β</i> cell regeneration would provide novel perspectives to preserve and/or expand pancreatic <i>β</i> cell mass for the treatment of T2D.
Synthesis and Application of Poly(phenylene Ethynylene)s for Bioconjugation:  A Conjugated Polymer-Based Fluorogenic Probe for Proteases (2005)

A set of carboxylate-functionalized poly(phenylene ethynylene)s (PPEs) has been synthesized in which the carboxylic acid groups are separated from the polymer backbone by oligo(ethylene glycol) spacer units. These polymers are soluble in water and organic solvents and have photophysical properties that are sensitive to solvent conditions, with high salt content and the absence of surfactant promoting the formation of aggregates of relatively low quantum yield and long fluorescence lifetime. Quenching of these materials by the dinitrophenyl (DNP) chromophore (K(SV) approximately 10(4)) is also highly solvent-dependent. The presence of carboxylate groups far from the polymer backbone appended to each repeating unit allows for the postpolymerization modification of these PPEs with peptides by methods analogous to those described for carboxylate-functionalized small-molecule dyes. Covalent attachment of the fluorescence-quenching 14-mer Lys(DNP)-GPLGMRGLGGGGK to the PPE results in a nonemissive substrate whose fluorescence is restored upon treatment with trypsin. The rate of fluorescence turn-on in this case is increased 3-fold by the presence of surfactant, though the actual rate of peptide hydrolysis remains the same. A small-molecule mimic of the polymer-peptide system shows a smaller fluorescence enhancement upon treatment with trypsin, illustrating the value of polymer-based amplification in this sensory scheme.
Novel 99mTc-Labeled Neurotensin Analogues with Optimized Biodistribution Properties (2006)

Two new 99mTc-labeled neurotensin(8-13) analogues containing the retro-N(alpha)-carboxymethyl-histidine ((N(alpha)His)Ac) chelator were synthesized as potential radiopharmaceuticals for visualization of pancreatic carcinoma. To improve the pharmacokinetic properties, (N(alpha)His)Ac-Arg-NMeArg-Pro-Tyr-Tle-Leu (NT-XII), which is metabolically stabilized at two positions, was further modified. Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) was introduced to obtain a more hydrophilic peptide (NT-XVIII), or Tyr11 was replaced by 2,6-dimethyltyrosine (Dmt) resulting in a triple-stabilized NT(8-13) analogue (NT-XIX). The latter has the best biodistribution profile.