gebhart/patrepeval huggingface dataset:
DEVELOPMENT AND CALIBRATION OF A PAVEMENT SURFACE PERFORMANCE MEASURE AND PREDICTION MODELS FOR THE BRITISH COLUMBIA PAVEMENT MANAGEMENT SYSTEM (2002)

Pavement surface distress is a key performance measure used by provincial/state and municipal roadway agencies in their asset management systems for rehabilitation programming. It is a true engineering measure of the pavement deterioration and can serve as a diagnostic tool to determine rehabilitation needs and treatments. This paper outlines the methodologies that the British Columbia Ministry of Transportation and Highways followed for refining its pavement distress index, which is based on the PAVER model and to develop regional, default pavement deterioration models. Developing the Pavement Distress Index (PDI) involved several iterations of model refinement incorporating other agencies work, data analyses, in-house pavement expertise, ground-truthing and post evaluations. The prediction models were constrained by input from regional pavement managers as well as the PDI data collected over a period of four years. Families of curves were developed for each of five treatment types, three climatic zones, three traffic levels and three equivalent pavement structural thickness.
An Efficient Intrathecal Delivery of Small Interfering RNA to the Spinal Cord and Peripheral Neurons (2005)

We have developed a highly effective method for in vivo gene silencing in the spinal cord and dorsal root ganglia (DRG) by a cationic lipid facilitated delivery of synthetic, small interfering RNA (siRNA). A siRNA to the delta opioid receptor (DOR), or a mismatch RNA, was mixed with the transfection reagent, i-Fect (vehicle), and delivered as repeated daily bolus doses (0.5 microg to 4 microg) via implanted intrathecal catheter to the lumbar spinal cord of rats. Twenty-four hours after the last injection, rats were tested for antinociception by the DOR selective agonist, [D-Ala(2), Glu(4)]deltorphin II (DELT), or the mu opioid receptor (MOR) selective agonist, [D-Ala(2), N-Me-Phe(4), Gly-ol(5)]enkephalin (DAMGO). Pretreatment with the siRNA, but not the mismatch RNA or vehicle alone, blocked DELT antinociception dose-dependently. The latter was concomitant with a reduction in the spinal immunoreactivity and receptor density of DOR, and in DOR transcripts in the lumbar DRG and spinal dorsal horn. Neither siRNA nor mismatch RNA pretreatment altered spinal immunoreactivity of MOR or antinociception by spinal DAMGO, and had no effect on the baseline thermal nociceptive threshold. The inhibition of function and expression of DOR by siRNA was reversed by 72 hr after the last RNA injection. The uptake of fluorescence-tagged siRNA was detected in both DRG and spinal cord. The low effective dose of siRNA/i-Fect complex reflects an efficient delivery of the siRNA to peripheral and spinal neurons, produced no behavioral signs of toxicity. This delivery method may be optimized for other gene targets.
Occurrence and geochemical activity of microorganisms in high‐temperature, water‐flooded oil fields of Kazakhstan and Western Siberia (1995)

The distribution of different methanogenic and sulfate‐reducing bacteria and their activity in formation waters of Uzen, Mykhpay, and Talinskoe oil fields, characterized by temperatures of the strata of 50–70°C and higher, were investigated. Injection of surface waters was shown to result in development of biogenic oil transformation. The temperature of injected waters determined the temperature regime and the presence of either mesophilic or thermophilic microorganisms in the microbial community near the bottom zone of injection wells. The number and activity of thermophilic microorganisms in the zone of producing wells were low or absent. Despite the absence of oxygen in the injected water, active microbiological processes occurred in the water‐flooded oil fields. We concluded that the development of biogenic processes in oil fields proceeded not only as an aerobic‐anaerobic microbiological succession but also as anaerobic transformation of organic matter injected with the surface water and of components of the oil itself.
Image deblurring with blurred/noisy image pairs (2007)

Taking satisfactory photos under dim lighting conditions using a hand-held camera is challenging. If the camera is set to a long exposure time, the image is blurred due to camera shake. On the other hand, the image is dark and noisy if it is taken with a short exposure time but with a high camera gain. By combining information extracted from both blurred and noisy images, however, we show in this paper how to produce a high quality image that cannot be obtained by simply denoising the noisy image, or deblurring the blurred image alone.
Remote sensing of future competitors: Impacts on plant defenses (2006)

Far-red radiation (FR) reflected by green tissues is a key signal that plants use to detect the proximity of future competitors. Perception of increased levels of FR elicits a suite of responses collectively known as the shade-avoidance syndrome, which includes increased stem elongation, production of erect leaves, and reduced lateral branching. These responses improve the access to light for plants that occur in crowded populations. Responses to the proximity of competitors are known to affect the susceptibility to disease and predation in several organisms, including social animals. However, the impacts of warning signals of competition on the expression of defenses have not been explicitly investigated in plants. In the experiments reported here, we show that reflected FR induced a dramatic down-regulation of chemical defenses in wild tobacco (Nicotiana longiflora). FR altered the expression of several defense-related genes, inhibited the accumulation of herbivore-induced phenolic compounds, and augmented the performance of the specialist herbivore Manduca sexta. Complementary studies with tomato suggested that the effects of FR on defenses are mediated by the photoreceptor phytochrome B. The central implication of these results is that shade-intolerant species such as wild tobacco and tomato activate functional changes that affect their ability to cope with herbivore attack in response to phytochrome signals of future competition, even in the absence of real competition for resources. These findings suggest that competition overshadowed herbivory during the evolution of this group of species and add a new axis to the definition of the shade-avoidance syndrome.
Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet α granules and differentially released (2007)

Platelets, in addition to their function in hemostasis, play an important role in wound healing and tumor growth. Because platelets contain angiogenesis stimulators and inhibitors, the mechanisms by which platelets regulate angiogenesis remain unclear. As platelets adhere to activated endothelium, their action can enhance or inhibit local angiogenesis. We therefore suspected a higher organization of angiogenesis regulators in platelets. Using double immunofluorescence and immunoelectron microscopy, we show that pro- and antiangiogenic proteins are separated in distinct subpopulations of alpha-granules in platelets and megakaryocytes. Double immunofluorescence labeling of vascular endothelial growth factor (VEGF) (an angiogenesis stimulator) and endostatin (an angiogenesis inhibitor), or for thrombospondin-1 and basic fibroblast growth factor, confirms the segregation of stimulators and inhibitors into separate and distinct alpha-granules. These observations motivated the hypothesis that distinct populations of alpha-granules could undergo selective release. The treatment of human platelets with a selective PAR4 agonist (AYPGKF-NH(2)) resulted in release of endostatin-containing granules, but not VEGF-containing granules, whereas the selective PAR1 agonist (TFLLR-NH(2)) liberated VEGF, but not endostatin-containing granules. In conclusion, the separate packaging of angiogenesis regulators into pharmacologically and morphologically distinct populations of alpha-granules in megakaryocytes and platelets may provide a mechanism by which platelets can locally stimulate or inhibit angiogenesis.
Multiple myeloma plasma cells show different chemokine receptor profiles at sites of disease activity (2007)

Chemokines and their receptors play a pivotal role in the regulation of B-lymphocyte trafficking. This study was aimed at investigating the pattern of chemokine receptor expression, including CCR1 to CCR3, CCR5 to CCR7, CXCR1 to CXCR5, and the migration ability of multiple myeloma (MM) plasma cells (PC). PC were recovered from the bone marrow (BM) of 29 MM patients, extramedullary sites of 10 patients and the BM of five controls. Flow cytometry analysis showed that the receptors mainly expressed on malignant BM PC were represented by CXCR4 (70% of patients), CCR1 (25%), CCR2 (25%), CCR5 (17%) and CXCR3 (20%), while other receptors were commonly lacking. The analysis performed on extramedullary (peripheral blood and pleural effusion) malignant PC demonstrated that the most represented receptors were CXCR4 (100%), CCR2 (66%) and CXCR1 (60%). The migratory capability of malignant PC at resting conditions identified three groups of patients with different migration (low, intermediate and high). As CXCR4 was the relevant chemokine receptor expressed by MM PC, its ligand CXCL12 induced their migration. These data suggest that malignant PC from MM display different chemokine receptor profiles and that CXCR4 is fully functional and might play a role in the spreading of the disease.
Challenges of Developing Therapeutics That Target Signal Transduction in Patients With Gynecologic and Other Malignancies (2003)

A greater understanding of cancer biology and major advances in biotechnology have resulted in the identification of a plethora of rationally designed, target-based anticancer therapeutics, particularly those that inhibit malignant-cell signal transduction, ushering in new therapeutic opportunities and extraordinary developmental challenges. Because these agents seem to principally target malignant cells, it is expected that they will produce less toxicity at clinically effective doses than nonspecific cytotoxic agents. The innate complexity of signaling networks, which have redundant relay systems that confer robustness, adaptability, and signaling diversity, also decreases the probability that any single therapeutic manipulation against any specific signaling element will be highly successful when used alone, particularly in patients with solid malignancies that have multiple relevant signaling aberrations. In addition, because the predominant therapeutic effect of inhibitors of signal transduction processes in preclinical studies is a decreased rate of tumor growth, it is anticipated that the predominant therapeutic outcome in the clinic will be similar; however, this end point is not readily detectable or quantifiable using traditional clinical evaluation methods. Furthermore, the results of preclinical and early clinical studies indicate that dose-toxicity relationships are not likely to be as steep as with nonspecific cytotoxic agents. Therefore, both regulatory and clinical practice end points, such as time to disease progression, disease-related symptoms, and quality of life, which are generally considered secondary for cytotoxic agents, may evolve into primary end points. The cumulative results of developmental evaluations to date indicate that the development, evaluation, and general clinical use of rationally designed, target-based anticancer therapeutics will require a radical departure from traditional paradigms to exploit the full potential of these new therapies.
Performance evaluation of traffic control based on geographical information (2009)

In mobile ad hoc networks, node's free movement is one of the most outstanding features. Due to mobility, link failure happens frequently so several communication problems such as low successful packet delivery ratio and large control overhead are naturally brought. However, node's mobility may bring dynamic situation, for example, distance between source and destination becomes closer or mobile node takes a role of bridge between disconnected areas. So, it needs to develop scheme as to take advantage of node's mobility. In this paper, we concern the improved throughput in mobility environments. To increase throughput in multihop networks, we design a new scheme to wait and send a packet when a source and destination is expected to be located closely. According to predicting position, we control transmission priority and time of packets as well as the amount of traffic. Simulation results are given to demonstrate the enhanced performance that drastic throughput enhancement is achieved by sacrificing increasing delay.
Similar Electrophysiological Changes in Axotomized and Neighboring Intact Dorsal Root Ganglion Neurons (2003)

We investigated electrophysiological changes in chronically axotomized and neighboring intact dorsal root ganglion (DRG) neurons in rats after either a peripheral axotomy consisting of an L5 spinal nerve ligation (SNL) or a central axotomy produced by an L5 partial rhizotomy (PR). SNL produced lasting hyperalgesia to punctate indentation and tactile allodynia to innocuous stroking of the foot ipsilateral to the injury. PR produced ipsilateral hyperalgesia without allodynia with recovery by day 10. Intracellular recordings were obtained in vivo from the cell bodies (somata) of axotomized and intact DRG neurons, some with functionally identified peripheral receptive fields. PR produced only minor electrophysiological changes in both axotomized and intact somata in L5 DRG. In contrast, extensive changes were observed after SNL in large- and medium-sized, but not small-sized, somata of intact (L4) as well as axotomized (L5) DRG neurons. These changes included (in relation to sham values) higher input resistance, lower current and voltage thresholds, and action potentials with longer durations and slower rising and falling rates. The incidence of spontaneous activity, recorded extracellularly from dorsal root fibers in vitro, was significantly higher (in relation to sham) after SNL but not after PR, and occurred in myelinated but not unmyelinated fibers from both L4 (9.1%) and L5 (16.7%) DRGs. We hypothesize that the changes in the electrophysiological properties of axotomized and intact DRG neurons after SNL are produced by a mechanism associated with Wallerian degeneration and that the hyperexcitability of intact neurons may contribute to SNL-induced hyperalgesia and allodynia.
No D2 Receptor Increase in PET Study of Schizophrenia (1987)

<h3>To the Editor.—</h3> Densities of D<sub>2</sub>dopamine receptors in postmortem brain tissue from schizophrenic patients have been found to be higher than those in control brains.<sup>1,2</sup>The pathophysiologic significance of this finding has been questioned, since elevated receptor densities may be caused by neuroleptic treatment.<sup>3</sup>It is now possible to examine D<sub>2</sub>dopamine receptor binding in the brains of living human subjects by means of new brain-imaging techniques and radiolabeled receptor ligands. Using a gamma camera and<sup>77</sup>Br-Bromospiperone, Crawley et al<sup>4</sup>reported evidence of a slight increase in D<sub>2</sub>dopamine receptors in a group of schizophrenic patients. Using positron emission tomography (PET) and<sup>11</sup>C<i>N</i>-Methylspiperone, Wong et al<sup>5</sup>recently reported a twofold to threefold elevation of D<sub>2</sub>dopamine receptor densities in the major basal ganglia of ten drug-naive and five previously treated schizophrenic patients. We previously used PET and
Variation in English: Multi-Dimensional Studies (2001)

Studies in Language and Linguistics General Editors- Geoffrey Leech, Department of Modern English Language, Lancaster University and Jenny Thomas, School of English and Linguistics, University of Wales, Bangor Broad-ranging and authoritative, Studies in Language and Linguistics is an occasional series incorporating major new work in all areas of linguistics. Variation in English- Multi-Dimensional Studies provides both a comprehensive view into a relatively new technique for studying language, and a diverse, exciting collection of studies of variation in English. The first part of the book provides an explanation of multi-dimensional (MD) analysis, a research technique for studying language variation. MD is a corpus-based approach developed by Doug Biber that facilitates large-scale studies of language variation and the investigation of research questions that were previously intractable. The second part of the book contains studies that apply Biber's original MD analysis of English to new domains. These studies cover the historical evolution of English; specialized domains such as medical writing and oral proficiency testing; and dialect variation, including gender and British/American. The third part of the book contains studies that conduct new MD analyses, covering adult/child language differences, 18th century speech and writing, and discourse complexity. Readers of this book will become familiar with the analytical techniques of multi-dimensional analysis, with its applicability to a wide variety of language issues, and with the findings of important studies previously published in diverse journals as well as new studies appearing for the first time.
Native and Mutant Forms of Cholera Toxin and Heat-Labile Enterotoxin Effectively Enhance Protective Efficacy of Live Attenuated and Heat-KilledShigellaVaccines (1999)

Both native and mutant forms of cholera toxin (CT) and heat-labile enterotoxin (LT) are effective adjuvants for antigens and killed whole-cell preparations. To determine whether these toxin molecules could also boost the immunogenicity and efficacy of live attenuated vaccines directed against shigellosis, the guinea pig keratoconjunctivitis model was used to evaluate the adjuvant effect of these toxin molecules on EcSf2a-3, a DeltavirG DeltaaroD Escherichia coli-Shigella flexneri 2a hybrid vaccine strain that was previously found to be less protective than its parent strain in the guinea pig model. Experiments using native and mutant toxin molecules showed that both CT and LT and mutant derivatives were effective as an adjuvant for EcSf2a-3 and that the mutant toxin molecules, which were developed to retain adjuvanticity without the toxicity associated with the native molecules, were as effective as the native toxin molecules as adjuvants. Protective efficacy was enhanced for both the oral and intranasal routes of immunization. Serum antibody response to the S. flexneri 2a O antigen, the primary antigen for protective immunity, was not dependent on the addition of an adjuvant. However, enumeration of the O-antigen-specific immunoglobulin G (IgG) and IgA antibody-secreting cells in the spleen and draining lymph nodes following intranasal immunization suggested that enhancement of the local immune response by the toxin molecules may contribute to the observed increase in protective efficacy. The efficacy of heat-killed S. flexneri 2a was enhanced only by mutant LT molecules. These results suggest that the best candidates for enhancing the efficacy of both live attenuated and heat-killed Shigella vaccines with minimal reactogenicity are the mutant toxin molecules.
Technology '88: transportation (1988)

This review of 1987 developments discusses the growing impetus toward automatic train control in the wake of the January 1987 accident involving an Amtrak passenger train. Also discussed are the growing use of gate-turnoff-thyristor-based converters in railroad equipment; growing interest in high-speed trains; and air safety problems. An expert opinion is offered by Richard A. Uher, director of Carnegie-Mellon University's Rail Systems Center, Pittsburgh, who describes two energy-cost-reduction schemes for transit systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Induced Pluripotent Stem Cells as a Model for Accelerated Patient- and Disease-specific Drug Discovery (2010)

Human induced pluripotent stem (iPS) cells hold great promise for therapy of a number of degenerative diseases such as ischemic heart failure, Parkinson's disease, Alzheimer's disease, diabetes mellitus, sickle cell anemia and Huntington disease. They also have the potential to accelerate drug discovery in 3 ways. The first involves the delineation of chemical components for efficient reprogramming of patient's blood cells or cells from biopsies, obviating the need for cellular delivery of reprogramming exogenous transgenes, thereby converting hope into reality for patients suffering from degenerative diseases. Patients worldwide stand to benefit from the clinical applicability of iPS cell-based cell replacement therapy for a number of degenerative diseases. The second is the potential for discovering novel drugs in a high throughput manner using patient-specific iPS cell-derived somatic cells possessing the etiology of the specific disease. The third is their suitability for toxicological testing of drugs and environmental factors. This review focuses on these potential applications of iPS cells with special emphasis on recent updates of iPS cell research contributing to the accelerated drug discovery.
Regulation of Src Family Kinases in Human Cancers (2011)

The nonreceptor protein tyrosine kinase Src plays a crucial role in the signal transduction pathways involved in cell division, motility, adhesion, and survival in both normal and cancer cells. Although the Src family kinases (SFKs) are activated in various types of cancers, the exact mechanisms through which they contribute to the progression of individual tumors remain to be defined. The activation of Src in human cancers may occur through a variety of mechanisms that include domain interaction and structural remodeling in response to various activators or upstream kinases and phosphatastes. Because of Src's prominent roles in invasion and tumor progression, epithelial-to-mesenchymal transition, angiogenesis, and the development of metastasis, Src is a promising target for cancer therapy. Several small molecule inhibitors of Src are currently being investigated in clinical trials. In this article, we will summarize the mechanisms regulating Src kinase activity in normal and cancer cells and discuss the status of Src inhibitor development against various types of cancers.
Analysis of the inhibition of tumour metastasis by sulphated polysaccharides (1987)

Lung metastases resulting from the intravenous (i.v.) injection of cells from the rat mammary adenocarcinoma 13762 MAT were significantly reduced by a variety of sulphated polysaccharides, the most effective being heparin, fucoidan and Carrageenan lambda. Although all the inhibitory polysaccharides were anticoagulants, it is unlikely that anticoagulation is the total explanation of their antimetastatic effect because: (i) heparin preparations from 2 different suppliers, although exhibiting comparable anticoagulant activities, differed 10-fold in their antimetastatic capability; (ii) certain sulphated polysaccharides consistently gave a 30% difference in the number of metastatic lesions, yet exhibited identical anticoagulant activity; and (iii) the entrapment of 13762 MAT cells in the lung was not impaired by heparin or fucoidan. It was more probable that the sulphated polysaccharides were interfering with the passaging of tumour cells across the capillary wall as heparin significantly inhibited metastasis when injected up to 3 hr after lodgement, and heparin and fucoidan caused a gradual loss of tumour cells from the lung which only became apparent greater than 1 hr following cell lodgement. The data did not eliminate the possibility that tumour cell adhesion to the endothelium occurred via sulphated polysaccharide recognition. A negative correlation existed between the sulphated polysaccharides that bound to the surface of the tumour cells and those that inhibited metastasis.