gebhart/patrepeval huggingface dataset:
Clinical evaluation of tumor targeting with a high-affinity, anticarcinoembryonic-antigen-specific, murine monoclonal antibody, MN-14 (1993)

These results suggest that MN-14 targets tumors effectively, even in the presence of elevated circulating CEA. Additional studies are necessary to determine if an advantage for the higher affinity MN-14 MoAb, compared with the lower affinity NP-4 MoAb, can be appreciated clinically.
Interleukin-1 receptor antagonist protein inhibits interleukin-8 expression in lipopolysaccharide-stimulated human whole blood. (1992)

Interleukin-8 (IL-8) is a neutrophil and lymphocyte chemoattractant and activator that may play an important role in mediating events at sites of inflammation. IL-8 is produced by many cell types in response to a variety of inducers, including interleukin-1 (IL-1). Studies were conducted to address the question of whether an inhibitor of IL-1 action, IL-1 receptor antagonist protein (IRAP), would suppress IL-8 production. Lipopolysaccharide (LPS)-stimulated human whole blood was used as an ex vivo model of local cytokine production. Preliminary time course studies showed that plasma IL-1 beta levels were fully induced by 6 hours (approximately 15 ng/ml) and persisted at this level over 24 hours. IL-8 production, in contrast, reached a plateau between 6 to 12 hours (5 ng/ml) and then increased rapidly to 17 ng/ml at 24 hours. Addition of IRAP was found to dose-dependently inhibit IL-8 expression at the levels of both protein and mRNA. A 50% reduction in IL-8 protein release occurred at an IRAP dose of 8 micrograms/ml (5 x 10(-7) mol/l) at 24 hours. A 2 hour delay in the addition of IRAP relative to LPS still permitted optimal reduction in IL-8 release, whereas delays of 4-8 hours reduced or eliminated the inhibitory effect. IRAP was found to have no effect on the LPS-stimulated production of IL-1 alpha or IL-1 beta. In addition, experiments performed with isolated peripheral blood cells demonstrated that, whereas monocytes were the major producers of IL-8, IRAP was equally effective in reducing IL-8 production in neutrophil and mononuclear cell suspensions. These studies further document the role of IL-1 in inducing the production of IL-8 and indicate that the ability of IRAP to suppress IL-8 expression may be an important mechanism of the anti-inflammatory properties of this molecule.
TREATMENT WITH THE HUMANIZED CD154-SPECIFIC MONOCLONAL ANTIBODY, hu5C8, PREVENTS ACUTE REJECTION OF PRIMARY SKIN ALLOGRAFTS IN NONHUMAN PRIMATES1 (2001)

These results show that treatment with the CD154-specific monoclonal antibody, hu5C8, greatly delays the onset of acute skin allograft rejection.
Bulk Segregant Analysis by High-Throughput Sequencing Reveals a Novel Xylose Utilization Gene from Saccharomyces cerevisiae (2010)

Fermentation of xylose is a fundamental requirement for the efficient production of ethanol from lignocellulosic biomass sources. Although they aggressively ferment hexoses, it has long been thought that native Saccharomyces cerevisiae strains cannot grow fermentatively or non-fermentatively on xylose. Population surveys have uncovered a few naturally occurring strains that are weakly xylose-positive, and some S. cerevisiae have been genetically engineered to ferment xylose, but no strain, either natural or engineered, has yet been reported to ferment xylose as efficiently as glucose. Here, we used a medium-throughput screen to identify Saccharomyces strains that can increase in optical density when xylose is presented as the sole carbon source. We identified 38 strains that have this xylose utilization phenotype, including strains of S. cerevisiae, other sensu stricto members, and hybrids between them. All the S. cerevisiae xylose-utilizing strains we identified are wine yeasts, and for those that could produce meiotic progeny, the xylose phenotype segregates as a single gene trait. We mapped this gene by Bulk Segregant Analysis (BSA) using tiling microarrays and high-throughput sequencing. The gene is a putative xylitol dehydrogenase, which we name XDH1, and is located in the subtelomeric region of the right end of chromosome XV in a region not present in the S288c reference genome. We further characterized the xylose phenotype by performing gene expression microarrays and by genetically dissecting the endogenous Saccharomyces xylose pathway. We have demonstrated that natural S. cerevisiae yeasts are capable of utilizing xylose as the sole carbon source, characterized the genetic basis for this trait as well as the endogenous xylose utilization pathway, and demonstrated the feasibility of BSA using high-throughput sequencing.
Editor's Note (1986)

The first two of the articles translated here appeared in Voprosy filosofii (Problems of Philosophy), the leading Soviet philosophical journal, in an unusual form which reflects the extraordinary degree of importance attached to their contents. The form is twofold: first, an exposition of the present Soviet approach to global problems that has been worked out by the all-embracing Academy of Sciences of the USSR and implemented by the CPSU. This is written by the Scientific Secretary of the Global Problems Section of the Academy's Scientific Council on Social Problems of Science and Technology, dealt with in the context of the contemporary revolution in science and technology. The exposition involves an unusually extensive documentation of relevant contemporary Soviet works. Second, attached to it is a critical analysis, at equal length, of the approach to global problems taken by leading representatives of contemporary Western bourgeois philosophy. This critique is written by a team of eight specialists of the Academy of Science's Institute of Philosophy.
New Porous Crystals of Extended Metal-Catecholates (2012)

ADVERTISEMENT RETURN TO ISSUECommunicationNEXTNew Porous Crystals of Extended Metal-CatecholatesMohamad Hmadeh†‡, Zheng Lu†‡, Zheng Liu§, Felipe Gándara†‡, Hiroyasu Furukawa†‡, Shun Wan†‡, Veronica Augustyn⊥, Rui Chang⊥, Lei Liao‡, Fei Zhou⊥, Emilie Perre⊥, Vidvuds Ozolins⊥, Kazu Suenaga§, Xiangfeng Duan‡, Bruce Dunn⊥, Yasuaki Yamamto∥, Osamu Terasaki#□, and Omar M. Yaghi*†‡#View Author Information† ‡ †Center for Reticular Chemistry, Center for Global Mentoring, ‡Department of Chemistry and Biochemistry, and ⊥Department of Materials Science and Engineering, University of California, Los Angeles, California 90095, United States§ Nanotube Research Center, AIST, Tsukuba 305-8565, Japan∥ SMBU, JEOL Ltd., Akishima, Tokyo 196-8558, Japan□ Department of Materials and Environmental Chemistry and EXSELENT, Stockholm University, Stockholm, Sweden# Graduate School of EEWS (WCU), Korea*E-mail: [email protected]Cite this: Chem. Mater. 2012, 24, 18, 3511–3513Publication Date (Web):August 28, 2012Publication History Received19 April 2012Revised22 August 2012Published online31 August 2012Published inissue 25 September 2012https://pubs.acs.org/doi/10.1021/cm301194ahttps://doi.org/10.1021/cm301194arapid-communicationACS PublicationsCopyright © 2012 American Chemical SocietyRequest reuse permissionsArticle Views33035Altmetric-Citations647LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Crystal structure,Electrical conductivity,Layers,Metal organic frameworks,Transmission electron microscopy Get e-Alerts
State of the Science (2010)

Perinatal asphyxia and resulting hypoxic ischemic encephalopathy (HIE) occur in 1 to 3 per 1000 births in the United States. Induced hypothermia as an intervention for asphyxiated infants offers promising results in reducing neurodevelopmental disabilities in surviving infants. Induced hypothermia and selective head cooling are effective interventions for asphyxiated infants that minimize continued neuronal damage and decrease neurodevelopmental disability at 18 months of age. Identification of affected infants immediately after delivery and transfer to a facility that provides this therapy is necessary to maximize the potential of this intervention. Standardization of hypothermia protocols within neonatal intensive care units is essential for providing hypothermia as a treatment of HIE in infants. This article explores the pathophysiology of HIE, identifying infants at risk for HIE as a result of perinatal asphyxia, the use of hypothermic intervention for compromised infants, and barriers to the implementation of treatment.
Model-based and learned semantic object labeling in 3D point cloud maps of kitchen environments (2009)

We report on our experiences regarding the acquisition of hybrid Semantic 3D Object Maps for indoor household environments, in particular kitchens, out of sensed 3D point cloud data. Our proposed approach includes a processing pipeline, including geometric mapping and learning, for processing large input datasets and for extracting relevant objects useful for a personal robotic assistant to perform complex manipulation tasks. The type of objects modeled are objects which perform utilitarian functions in the environment such as kitchen appliances, cupboards, tables, and drawers. The resulted model is accurate enough to use it in physics-based simulations, where doors of 3D containers can be opened based on their hinge position. The resulted map is represented as a hybrid concept and is comprised of both the hierarchically classified objects and triangular meshes used for collision avoidance in manipulation routines.
On routing asymmetry in the Internet (2005)

Routing asymmetry in the Internet can significantly affect the manner in which we model and simulate its behavior. In this paper, we study routing asymmetry in the Internet and present quantitative evaluations on the extent of such asymmetry today. Our quantitative evaluations provide a measure of the difference between the forward and reverse paths between two end points. Routing asymmetry has not been studied extensively before; this is primarily due to the lack of a systematic approach for quantifying asymmetry except for simply computing the difference between the forward and reverse path lengths. By applying our framework for representing asymmetry, we quantify routing asymmetry for both US higher education academic networks and general commercial networks at two different levels: the autonomous system (AS) level and the router (or link) level. We take into consideration, not only the difference in the forward and reverse path lengths, but also the AS and link identities and the sequence in which these entities appear on the paths. We measure the AS level routing asymmetry, and provide upper lower bounds on link level routing asymmetry. Our studies show that academic networks appear to be more symmetric than general commercially deployed networks. Furthermore, our studies demonstrate that routing asymmetry exhibits a skewed distribution i.e., a few end-points seem to display a higher extent of participation on asymmetric routes.
Advanced Deployable Shell-Based Composite Booms for Small Satellite Structural Applications Including Solar Sails (2017)

State of the art deployable structures are mainly being designed for medium to large size satellites. The lack of reliable deployable structural systems for low cost, small volume, rideshare-class spacecraft severely constrains the potential for using small satellite platforms for affordable deep space science and exploration precursor missions that could be realized with solar sails. There is thus a need for reliable, lightweight, high packaging efficiency deployable booms that can serve as the supporting structure for a wide range of small satellite systems including solar sails for propulsion. The National Air and Space Administration (NASA) is currently investing in the development of a new class of advanced deployable shell-based composite booms to support future deep space small satellite missions using solar sails. The concepts are being designed to: meet the unique requirements of small satellites, maximize ground testability, permit the use of low-cost manufacturing processes that will benefit scalability, be scalable for use as elements of hierarchical structures (e.g. trusses), allow long duration storage, have high deployment reliability, and have controlled deployment behavior and predictable deployed dynamics. This paper will present the various rollable boom concepts that are being developed for 5-20 m class size deployable structures that include solar sails with the so-called High Strain Composites (HSC) materials. The deployable composite booms to be presented are being developed to expand the portfolio of available rollable booms for small satellites and maximize their length for a given packaged volume. Given that solar sails are a great example of volume and mass optimization, the booms were designed to comply with nominal solar sail system requirements for 6U CubeSats, which are a good compromise between those of smaller form factors (1U, 2U and 3U CubeSats) and larger ones (12 U and 27 U future CubeSats, and ESPA-class microsatellites). Solar sail missions for such composite boom systems are already under consideration and development at NASA, as well as mission studies that will benefit from planned scaled-up versions of the composite boom technologies to be introduced. The paper presents ongoing research and development of thin-shell rollable composite booms designed under the particular stringent and challenging system requirements of relatively large solar sails housed on small satellites. These requirements will be derived and listed. Several new boom concepts are proposed and other existing ones are improved upon using thin-ply composite materials to yield unprecedented compact deployable structures. Some of these booms are shown in Fig. 1. For every boom to be introduced the scalable fabrication process developed to keep the overall boom system cost down will be shown. Finally, the initial results of purposely designed boom structural characterization test methods with gravity off-loading will be presented to compare their structural performance under expected and general load cases.
Thyroid Adenocarcinomas Secondary to Tissue-Specific Expression of Simian Virus-40 Large T-Antigen in Transgenic Mice* (1991)

A hybrid gene comprising the bovine thyroglobulin gene promoter and the coding region for the simian virus-40 large T- and small t-antigens was used to generate 30 transgenic mice by microinjection into the pronuclei of single cell embryos. All animals except three developed, as single primitive pathology, a dramatic enlargement of the thyroid gland. Compression of trachea and esophagus, accompanied by dyspnea, inspiratory stridor, and dysphagia, led to a progressive cachexia and premature death attributed to respiratory failure. Despite the large thyroid volume, T4 levels were abnormally low, and the progression of the syndrome could be delayed by a substitutive treatment with thyroid hormones. The rapid evolution of the disease, leading to the death of most founder transgenic animals before the breeding age, prevented transmission of the transgene to their offspring. Only two transgenic lines are presently surviving. Immunohistochemical analysis of the tissues revealed a specific expression of the simian virus-40 antigens in the thyroid cells. Hyperplasia was already obvious at birth. Older animals displayed moderately to poorly differentiated thyroid adenocarcinomas. Electron microscopy revealed, however, the persistence of cell polarity and the presence of microfollicles between the densely packed cells. Cell lines derived from these large T-expressing thyroids were shown to have lost expression of both thyroglobulin and thyroperoxidase, while expressing low levels of TSH receptors. These transgenic mice could constitute an interesting model of aggressive adenocarcinoma, sharing phenotypical similarities with the anaplastic type of human thyroid tumors.
Increase in the Prevalence of the Newly Discovered Pneumococcal Serotype 6C in the Nasopharynx after Introduction of Pneumococcal Conjugate Vaccine (2008)

Among NP isolates, the prevalence of 6C isolates has increased and the prevalence of 6A isolates has decreased since the introduction of PCV7 in Massachusetts in 2000. The observed increase in serotype 6C prevalence may be explained by the induction by PCV7 of low amounts of functional anti-6C antibody, compared with anti-6A and anti-6B antibodies.
The Efficacy of Single-Dose Administration of Thrombopoietin With Coadministration of Either Granulocyte/Macrophage or Granulocyte Colony-Stimulating Factor in Myelosuppressed Rhesus Monkeys (1997)

Thrombopoietin (TPO) was evaluated for efficacy in a placebo-controlled study in rhesus monkeys with concurrent administration of either granulocyte/macrophage colony-stimulating factor (GM-CSF) or granulocyte CSF, (G-CSF). Rhesus monkeys were subjected to 5 Gy total-body irradiation (TBI), resulting in 3 weeks of profound pancytopenia, and received either TPO 5 μg/kg intravenously (IV) at day 1 (n = 4), GM-CSF 25 μg/kg subcutaneously (SC) for 14 days (n = 4), TPO and GM-CSF (n = 4), G-CSF 10 μg/kg/d SC for 14 days (n = 3), TPO and G-CSF (n = 4), or placebo (carrier, n = 4; historical controls, n = 8). Single-dose IV treatment with TPO 1 day after TBI effectively counteracted the need for thrombocyte transfusions (provided whenever thrombocyte levels were &lt;40 × 109/L) and accelerated platelet reconstitution to normal levels 2 weeks earlier than placebo controls. TPO/GM-CSF was more effective than single-dose TPO alone in stimulating thrombocyte regeneration, with a less profound nadir and a further accelerated recovery to normal thrombocyte counts, as well as a slight overshoot to supranormal levels of thrombocytes. Monkeys treated with TPO/GM-CSF uniformly did not require thrombocyte transfusions, whereas those treated with GM-CSF alone needed two to three transfusions, similar to the placebo-treated monkeys, which required, on average, three transfusions. Also, reticulocyte production was stimulated by TPO and further augmented in monkeys treated with TPO/GM-CSF. TPO alone did not stimulate neutrophil regeneration, whereas GM-CSF shortened the period of neutrophil counts less than 0.5 × 109/L by approximately 1 week; TPO/GM-CSF treatment elevated the neutrophil nadir, but did not further accelerate recovery to normal values. TPO also augemented the neturophil response to G-CSF, resulting in similar patterns of reconstitution following TPO/G-CSF and TPO/GM-CSF treatment. TPO/GM-CSF resulted in significantly increased reconstitution of CD34+ bone marrow cells and progenitor cells such as GM-CFU and BFU-E. Adverse effects of combining TPO with the CSFs were not observed. It is concluded that (1) a single IV administration of TPO is sufficient to prevent severe thrombocytopenia following myelosuppression, (2) TPO/G-CSF and TPO/GM-CSF treatment result in distinct response patterns, with TPO/GM-CSF being superior to TPO/G-CSF in stimulating thrombocyte and erythrocyte recovery while being equivalent in stimulating neutrophil recovery; and (3) TPO significantly improves the performance of CSFs in alleviating severe neutropenia.
Treatment of deep sternal wound infections post‐open heart surgery by application of activated macrophage suspension (2005)

Postoperative sternal wound infection remains a significant complication and generally causes considerable morbidity and mortality. Macrophages play a major role in the process of wound healing. In order to evaluate the efficacy of local injection of activated macrophage suspensions into open infected sternal wound space, a retrospective case-control study was conducted. Sixty-six patients with deep sternal wound infection treated by activated macrophages (group 1) and 64 patients with deep sternal wound infection treated by sternal reconstruction surgery with various regional flaps (group 2), were matched for gender, age, and risk index. In up to 54 months of follow-up of group 1, 60 patients (91%) achieved complete wound closure. Two (3%) late deaths occurred unrelated to the procedure. Mortality rate in group 2 was 29.7% (19/64). Duration of hospitalization was 22.6 days in group 1 vs. 56.2 days in group 2. Patients with deep sternal wound infection following open heart surgery that were treated by activated macrophages had significantly less mortality as well as significant reduction of hospitalization in comparison to the surgically treated group. These results illustrate the advantages of using a biologically based activated macrophage treatment.
Towards all around automatic visual obstacle sensing for cars (2005)

We currently work on the implementation of an integrated prototype system that provides "all around" automatic visual obstacle sensing for a Daimler-Benz test car. Most of the machine vision techniques being used have been developed within the European PROMETHEUS programme and a number of other research projects carried out by the authors and other affiliates of their institutions. This includes robust symmetry measuring, neural net-based adaptive object detection and tracking, and inverse-perspective stereo image matching and robust scale estimation in time.
10-wavelength 200-GHz channel spacing emitter integrating DBR lasers with a PHASAR on InP for WDM applications (1999)

A 10-wavelength 200-GHz channel spacing emitter was realized by monolithically integrating on InP a 10 distributed-Bragg-reflector laser array and a PHASAR used as a 10/spl rarr/1 combiner. The design of a wide-squared spectral bandwidth for the PHASAR as well as the lasers tunability ensure wavelength matching between the PHASAR transmission comb and the laser array comb. The channel spacing accuracy of the source is better than 25 GHz and the rejection is higher than 32 dB for all bias.