gebhart/patrepeval huggingface dataset:
An RNA-Based Information Superhighway in Plants (1998)

In their commentary, Jorgensen
 et al . propose that plants contain a mechanism designed to transfer information over long distances--similar in function to an animal9s bloodstream or nervous system. The authors integrate recent work on a phenomenon called cosupression, in which introduced genes can suppress expression of the plant9s own genes, with other research on how plants resist viral infections and suggest that information-carrying molecules (likely RNAs) move through the plant in long tubes (phloem) and regulate cell physiology at a distance.
Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients (2013)

This study provides Class IV evidence that bilateral neurturin gene delivery (CERE-120) to the SN plus putamen in patients with moderately advanced PD is feasible and safe.
Induction of Dendritic Cell Production of Type I and Type III Interferons by Wild-Type and Vaccine Strains of Measles Virus: Role of Defective Interfering RNAs (2013)

The innate immune response to viral infection frequently includes induction of type I interferons (IFN), but many viruses have evolved ways to block this response and increase virulence. In vitro studies of IFN production after infection of susceptible cells with measles virus (MeV) have often reported greater IFN synthesis after infection with vaccine than with wild-type strains of MeV. However, the possible presence in laboratory virus stocks of 5' copy-back defective interfering (DI) RNAs that induce IFN independent of the standard virus has frequently confounded interpretation of data from these studies. To further investigate MeV strain-dependent differences in IFN induction and the role of DI RNAs, monocyte-derived dendritic cells (moDCs) were infected with the wild-type Bilthoven strain and the vaccine Edmonston-Zagreb strain with and without DI RNAs. Production of type I IFN, type III IFN, and the interferon-stimulated genes (ISGs) Mx and ISG56 by infected cells was assessed with a flow cytometry-based IFN bioassay, quantitative reverse transcriptase PCR (RT-PCR), and immunoassays. Bilthoven infected moDCs less efficiently than Edmonston-Zagreb. Presence of DI RNAs in vaccine stocks resulted in greater maturation of moDCs, inhibition of virus replication, and induction of higher levels of IFN and ISGs. Production of type I IFN, type III IFN, and ISG mRNA and protein was determined by both the level of infection and the presence of DI RNAs. At the same levels of infection and in the absence of DI RNA, IFN induction was similar between wild-type and vaccine strains of MeV.
Using context and similarity for face and location identification (2006)

This paper describes a new approach to the automatic detection of human faces and places depicted in photographs taken on cameraphones. Cameraphones offer a unique opportunity to pursue new approaches to media analysis and management: namely to combine the analysis of automatically gathered contextual metadata with media content analysis to fundamentally improve image content recognition and retrieval. Current approaches to content-based image analysis are not sufficient to enable retrieval of cameraphone photos by high-level semantic concepts, such as who is in the photo or what the photo is actually depicting. In this paper, new methods for determining image similarity are combined with analysis of automatically acquired contextual metadata to substantially improve the performance of face and place recognition algorithms. For faces, we apply Sparse-Factor Analysis (SFA) to both the automatically captured contextual metadata and the results of PCA (Principal Components Analysis) of the photo content to achieve a 60% face recognition accuracy of people depicted in our database of photos, which is 40% better than media analysis alone. For location, grouping visually similar photos using a model of Cognitive Visual Attention (CVA) in conjunction with contextual metadata analysis yields a significant improvement over color histogram and CVA methods alone. We achieve an improvement in location retrieval precision from 30% precision for color histogram and CVA image analysis, to 55% precision using contextual metadata alone, to 67% precision achieved by combining contextual metadata with CVA image analysis. The combination of context and content analysis produces results that can indicate the faces and places depicted in cameraphone photos significantly better than image analysis or context analysis alone. We believe these results indicate the possibilities of a new context-aware paradigm for image analysis.
Desorption stimulated by laser-induced surface-plasmon excitation (1988)

Atoms with energies of several electronvolts are ejected if small metal particles are illuminated with low-intensity visible laser light. The desorption rate exhibits a resonant behavior with its maximum at \ensuremath{\lambda}=490 nm for particles of 50 nm average radius. The novel process is explained by a mechanism of laser-induced desorption that is based on surface-plasmon excitation.
Do valved stents compromise coronary flow?☆ (2004)

This new self-expanding valved stent design allows for on- and off-pump aortic valve implantation in the orthotopic aorta, over the native valves without interference of the coronary blood flow and excellent acute valve function in properly sized devices.
Core 2 β1,6‐N‐acetylglucosaminyltransferases and α1,3‐fucosyltransferases regulate the synthesis of O‐glycans on selectin ligands on oral cavity carcinoma cells (2001)

Selectin-dependent cell binding has importance in the extravasation of blood-circulating tumor cells and in the generation of metastases. Cell surface glycoproteins decorated with sialylated, fucosylated epitopes, such as sialyl Lewis(x) (sLe(x)), are ligands for selectins. Not only terminal sLe(x) moieties but also proximal core structures contribute to the formation of binding epitopes for selectins. Core 2 beta1,6-N-acetylglucosaminyltransferases (C2GnT) and alpha1,3-fucosyltransferases (alpha1,3-FucT) have been suggested to be the rate-limiting enzymes in the synthesis of selectin ligands. We analyzed oral cavity epithelial carcinoma cell lines and showed their expression of RNA transcripts for C2GnT and alpha1,3-FucT, identified alpha1,3-FucT enzyme activities, and analyzed the cell surface sLe(x) expression levels. Neither the pattern of expressed enzymes nor the alpha1,3-FucT activity directly predicted the binding capacity of E-selectin. However, only the sLe(x)-expressing cell lines were capable of binding to E-selectin, but not to P-selectin, thus putatively promoting the selectin-mediated metastasis. These findings suggest that C2GnT in combination with alpha1,3-Fuc-T contribute to the selectin-mediated metastasis in oral cavity carcinomas.
Marine natural products (1997)

Marine natural products D. John Faulkner Scripps Institution of Oceanography University of California San Diego La Jolla CA 92093-0212 USA Covering 1995 Previous review 1996 13 75 1 Introduction 2 Marine microorganisms and phytoplankton 3 Green algae 4 Brown algae 5 Red algae 6 Sponges 7 Coelent
Corticosteroids and Azathioprine Do Not Prevent Radiation‐Induced Lung Injury (1998)

The case of a man who presented with dyspnea and a dry cough six weeks after mediastinal radiotherapy for malignant thymoma is described. The patient was on prednisone (30 mg/day) and azathioprine (100 mg/day) throughout the course of radiation. The respiratory difficulties developed as the dose of prednisone was gradually decreased to 20 mg/day postradiation. Chest x-ray showed bilateral pulmonary infiltrates. Computed tomography scan of the thorax confirmed bilateral ground glass opacities, with well-defined lateral margin on the right side corresponding to the field of radiation. However, the airspace opacities extended beyond the radiation field into the periphery of the lungs together with mild airway dilation on the left side compatible with bronchiolitis obliterans organizing pneumonia (BOOP) or cryptogenic organizing pneumonia. Bronchoalveolar lavage performed on the nonirradiated area showed an intense lymphocytosis. No cause of BOOP other than radiation was found. Treatment with high dose corticosteroids (80 mg/day) resulted in rapid clinical and radiological improvement, and resolution of chest x-ray abnormalities. Focal mediastinal radiation therapy may induce diffuse lung injury including BOOP. In addition, the concurrent use of moderate dose prednisone and azathioprine during the periradiotherapy period does not prevent the development of either BOOP or classic radiation pneumonitis.
Molecular cloning and primary structure of human chromogranin A (secretory protein I) cDNA. (1988)

Chromogranin A (CGA), also referred to as secretory protein I, is an acidic protein that has been detected in all neuroendocrine cell types examined and is often present in large amounts relative to other secreted proteins. For example, CGA comprises at least 40% of the soluble protein of the adrenal chromaffin granule, and it appears to be the major secretory protein in the parathyroid secretory granules. CGA complementary DNAs (cDNAs) from bovine adrenal and pituitary have recently been cloned and sequenced and found to be nearly identical. A region of bovine CGA has a high degree of amino acid sequence identity to pancreastatin, a recently isolated porcine peptide that inhibits glucose-induced insulin secretion. This suggests that CGA may be a prohormone. We have cloned and sequenced a human cDNA encoding CGA. This human CGA cDNA has an overall 86% nucleic acid identity to the bovine cDNA. Like the bovine CGA cDNA, the human cDNA has little homology to pancreastatin at the 5' region of this peptide but significant amino acid homology to the carboxyl-terminal portion of pancreastatin where the biologic activity resides. There is an area within the pancreastatin region of human CGA and porcine pancreastatin with a 70% amino acid identity to the calcium-binding moiety of the E-F hand proteins such as parvalbumin and oncomodulin. These data suggest that CGA and pancreastatin may both be members of a larger family of calcium-binding proteins.
Gradient domain high dynamic range compression (2002)

We present a new method for rendering high dynamic range images on conventional displays. Our method is conceptually simple, computationally efficient, robust, and easy to use. We manipulate the gradient field of the luminance image by attenuating the magnitudes of large gradients. A new, low dynamic range image is then obtained by solving a Poisson equation on the modified gradient field. Our results demonstrate that the method is capable of drastic dynamic range compression, while preserving fine details and avoiding common artifacts, such as halos, gradient reversals, or loss of local contrast. The method is also able to significantly enhance ordinary images by bringing out detail in dark regions.
Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization (2000)

We have identified three C/D-box small nucleolar RNAs (snoRNAs) and one H/ACA-box snoRNA in mouse and human. In mice, all four snoRNAs (MBII-13, MBII-52, MBII-85, and MBI-36) are exclusively expressed in the brain, unlike all other known snoRNAs. Two of the human RNA orthologues (HBII-52 and HBI-36) share this expression pattern, and the remainder, HBII-13 and HBII-85, are prevalently expressed in that tissue. In mice and humans, the brain-specific H/ACA box snoRNA (MBI-36 and HBI-36, respectively) is intron-encoded in the brain-specific serotonin 2C receptor gene. The three human C/D box snoRNAs map to chromosome 15q11-q13, within a region implicated in the Prader-Willi syndrome (PWS), which is a neurogenetic disease resulting from a deficiency of paternal gene expression. Unlike other C/D box snoRNAs, two snoRNAs, HBII-52 and HBII-85, are encoded in a tandemly repeated array of 47 or 24 units, respectively. In mouse the homologue of HBII-52 is processed from intronic portions of the tandem repeats. Interestingly, these snoRNAs were absent from the cortex of a patient with PWS and from a PWS mouse model, demonstrating their paternal imprinting status and pointing to their potential role in the etiology of PWS. Despite displaying hallmarks of the two families of ubiquitous snoRNAs that guide 2'-O-ribose methylation and pseudouridylation of rRNA, respectively, they lack any telltale rRNA complementarity. Instead, brain-specific C/D box snoRNA HBII-52 has an 18-nt phylogenetically conserved complementarity to a critical segment of serotonin 2C receptor mRNA, pointing to a potential role in the processing of this mRNA.
Studies Towards the Synthesis of the Saturated and Unsaturated Carbocyclic Methylene Phosphonate Analogs of Dideoxyadenosine (1993)

Abstract The synthesis of the saturated carbocyclic methylene phosphonate analog of ddAMP is described by two different methods (epoxyde opening and “purinoselenylation”). Studies towards the formation of 2′,3′ unsaturated analogs by selenoxyde or mesylate elimination are also reported.
Dioxygen Activation by Enzymes with Mononuclear Non-Heme Iron Active Sites (1996)

ADVERTISEMENT RETURN TO ISSUEPREVarticleNEXTDioxygen Activation by Enzymes with Mononuclear Non-Heme Iron Active SitesLawrence Que Jr.* and Raymond Y. N. HoView Author Information Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455 In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.Cite this: Chem. Rev. 1996, 96, 7, 2607–2624Publication Date (Web):November 7, 1996Publication History Received9 April 1996Revised5 August 1996Published online7 November 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/cr960039fhttps://doi.org/10.1021/cr960039fresearch-articleACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views5607Altmetric-Citations677LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aromatic compounds,Iron,Ligands,Monomers,Peptides and proteins Get e-Alerts
Detection of Escherichia coli using immunomagnetic separation and bacteriophage amplification coupled with matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (2002)

The application of whole cell analysis by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has emerged as a valuable tool for rapidly identifying/detecting bacteria. This technique requires minimal sample preparation and is simple to perform, but is generally limited to purified samples of bacteria at concentrations greater than 1.0 x 10(6) cells/mL. In this paper, we describe a bacterial detection method that integrates immunomagnetic separation with bacteriophage amplification prior to MALDI-MS analysis. The developed method consists of three main stages: (1) isolation of a target bacterium by immunomagnetic separation; (2) infection of the immuno-captured bacterium with a lytic bacteriophage; and (3) assay of infected medium for bacteriophage progeny using MALDI-MS to produce a molecular weight signal for the virus capsid protein. With this technique, the presence of Escherichia coli in broth was determined in less then 2 h total analysis time at a concentration of approximately 5.0 x 10(4) cells/mL.
An autonomous decentralized system platform under multi-vendor environments in building automation (2002)

The paper proposes an autonomous decentralized building control system to cope with the requirements of building control systems under multi-vendor environments. In the proposed system building equipment is horizontally distributed on a network and autonomously works by sharing communication data on the network according to objects for building control systems. The proposed system deals with the requirements of building control systems and offers its users, such as building designers, a user-friendly tool for the system construction. The authors call such a communication platform an autonomous decentralized system (ADS) platform. By utilizing the ADS platform, the building control system obtains two ADS properties, i.e., autonomous controllability and autonomous coordinability. Furthermore the proposed system can realize the on-line expandability, on-line maintainability and fault tolerance of the system by relaying messages between the building system objects on the ADS platform without specifying the sending addresses.
LEDs: A flexible option for machine vision (2002)

Describes the benefits that arise from the use of Light Emitting Diodes (LEDs) for illumination in industrial machine vision systems. These include long life, stability and narrow frequency bands. Also discusses precautions that need to be taken for obtaining a uniform illumination and pulsed operation.
Overexpression of SUR2A generates a cardiac phenotype resistant to ischemia (2006)

ATP-sensitive K+ (K(ATP)) channels are present in the sarcolemma of cardiac myocytes where they link membrane excitability with the cellular bioenergetic state. These channels are in vivo composed of Kir6.2, a pore-forming subunit, SUR2A, a regulatory subunit, and at least four accessory proteins. In the present study, real-time RT-PCR has demonstrated that of all six sarcolemmal K(ATP) channel-forming proteins, SUR2A was probably the least expressed protein. We have generated mice where the SUR2A was under the control of a cytomegalovirus promoter, a promoter that is more efficient than the native promoter. These mice had an increase in SUR2A mRNA/protein levels in the heart whereas levels of mRNAs of other channel-forming proteins were not affected at all. Imunoprecipitation/Western blot and patch clamp electrophysiology has shown an increase in K(ATP) channel numbers in the sarcolemma of transgenic mice. Cardiomyocytes from transgenic mice responded to hypoxia with shortening of action membrane potential and were significantly more resistant to this insult than cardiomyocytes from the wild-type. The size of myocardial infarction in response to ischemia-reperfusion was much smaller in hearts from transgenic mice compared to those in wild-type. We conclude that overexpression of SUR2A generates cardiac phenotype resistant to hypoxia/ischemia/reperfusion injury due at least in part to increase in levels of sarcolemmal K(ATP) channels.
Fast Connection Establishment in the DTM Gigabit Network (1994)

Dynamic synchronous Transfer Mode (DTM) is a new protocol suite based on synchronous fast circuit switching. The DTM network is based on bandwidth reservation and supports dynamic reallocation of bandwidth. It is designed to support real-time multimedia applications and high-speed computer communication. DTM uses a novel medium-access technique and provides a multicast connection-oriented service. In this paper, the connection establishment in the DTM network is discussed and a scheme for fast connection establishment is presented. The scheme allows for fast set-up of channels which results in an efficient usage of the network&amp;apos;s bandwidth and a short access delay for the user. Buffer handling and memory management implementations at a host interface supporting this scheme are also presented. Keyword Codes: C.2.0, C.2.1, C.2.2 Keywords: Computer-Communication Networks, General; Network Architecture and Design; Network Protocols 1. Introduction The need for high speed networks is dri...
Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes. (1995)

Vascular cell adhesion molecule-1 (VCAM-1), an inducible cell-cell recognition protein on the endothelial cell surface (EC), has been associated with early stages of atherosclerosis. In view of the accelerated vascular disease observed in patients with diabetes, and the enhanced expression of VCAM-1 in diabetic rabbits, we examined whether irreversible advanced glycation endproducts (AGEs), could mediate VCAM-1 expression by interacting with their endothelial cell receptor (receptor for AGE, RAGE). Exposure of cultured human ECs to AGEs induced expression of VCAM-1, increased adhesivity of the monolayer for Molt-4 cells, and was associated with increased levels of VCAM-1 transcripts. The inhibitory effect of anti-RAGE IgG, a truncated form of the receptor (soluble RAGE) or N-acetylcysteine on VCAM-1 expression indicated that AGE-RAGE-induced oxidant stress was central to VCAM-1 induction. Electrophoretic mobility shift assays on nuclear extracts from AGE-treated ECs showed induction of specific DNA binding activity for NF-kB in the VCAM-1 promoter, which was blocked by anti-RAGE IgG or N-acetylcysteine. Soluble VCAM-1 antigen was elevated in human diabetic plasma. These data are consistent with the hypothesis that AGE-RAGE interaction induces expression of VCAM-1 which can prime diabetic vasculature for enhanced interaction with circulating monocytes.
Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis (2002)

This review considers critically the evidence for the involvement of mediators of innate and acquired immunity in various stages of atherosclerosis. Rapidly mobilized arms of innate immunity, including phagocytic leukocytes, complement, and proinflammatory cytokines, contribute to atherogenesis. In addition, adaptive immunity, with its T cells, antibodies, and immunoregulatory cytokines, powerfully modulates disease activity and progression. Atherogenesis involves cross talk between and shared pathways involved in adaptive and innate immunity. Immune processes can influence the balance between cell proliferation and death, between synthetic and degradative processes, and between pro- and antithrombotic processes. Various established and emerging risk factors for atherosclerosis modulate aspects of immune responses, including lipoproteins and their modified products, vasoactive peptides, and infectious agents. As we fill in the molecular details, new potential targets for therapies will doubtless emerge.