gebhart/patrepeval huggingface dataset:
Iron deficiency syndromes and iron‐restricted erythropoiesis (CME) (2011)

The relationships between erythropoietin (EPO), iron, and erythropoiesis and the presence of iron-restricted erythropoiesis have important implications in anemia management. Iron-restricted erythropoiesis occurs in the presence of one or more iron deficiency syndromes: absolute iron deficiency, functional iron deficiency, and/or iron sequestration. Absolute iron deficiency is a common nutritional deficiency in women's health, pediatrics, and the elderly and is therefore an important public health problem. Functional iron deficiency occurs in patients with significant EPO-mediated erythropoiesis or therapy with erythropoiesis-stimulating agents, even when storage iron is present. Iron sequestration mediated by hepcidin is an underappreciated but common cause of iron-restricted erythropoiesis in patients with chronic inflammatory disease. The challenge for treating and laboratory-based physicians is to understand the contributory role(s) of each of these syndromes, so that the potential value of emerging and innovative pharmacologic strategies can be considered as options in patient blood management.
Isolation of an Adult Mouse Lung Mesenchymal Progenitor Cell Population (2007)

Contained within the adult lung are differentiated mesenchymal cell types (cartilage, smooth muscle, and myofibrobasts) that provide structural support for airways and vessels. Alterations in the number and phenotype of these cells figure prominently in the pathogenesis of a variety of lung diseases. While these cells are thought to arise locally, progenitors have yet to be purified. In previous work, we developed a method for isolating progenitors from lung tissue: this technique takes advantage of the unique ability of cell populations enriched for somatic stem and progenitor activity to efflux the vital dye Hoechst 33342, a feature that permits isolation by flow cytometry-based procedures. Using this method, we determined that a rare population of mesenchymal progenitors resides within the CD45- CD31- Hoechst low fraction of the adult murine lung. Similar to other mesenchymal progenitors, these cells express Sca-1, CD106, and CD44; can be serially passaged; and can differentiate to smooth muscle, cartilage, bone, and fat. Overall, these findings demonstrate that a phenotypically distinct mesenchymal progenitor resides within the adult murine lung, and provide a scheme for their isolation and study.
Task-reconfigurable robots: navigators and manipulators (2002)

Task-reconfigurable robots consist of a set of one or more identical autonomous modules that can adapt their shape and function to tasks. We describe a module, the Inchworm robot, that can function as a climbing robot, a manipulator, or a leg in a multi-legged walker. This module can make autonomous transitions between these states. We present the control algorithms that enable our robot to be a versatile navigator and manipulator and report on our experimental results.
JEAN-RICHARD BLOCH'S PLAY TOULON AND THE SCUTTLING OF THE FRENCH FLEET ON 27 NOVEMBER 1942 (1992)

JEAN-RICHARD BLOCH'S PLAY TOULON AND THE SCUTTLING OF THE FRENCH FLEET ON 27 NOVEMBER 1942 Get access TED FREEMAN TED FREEMAN Bristol Search for other works by this author on: Oxford Academic Google Scholar French Studies Bulletin, Volume 12, Issue 45, WINTER 1992, Pages 20–21, https://doi.org/10.1093/frebul/12.45.20 Published: 01 December 1992
Application of Neural Networks for Sensor Validation and Plant Monitoring (1992)

Sensor and process monitoring in power plants requires the estimation of one or more process variables. Neural network paradigms are suitable for establishing general nonlinear relationships among a set of plant variables. Multiple-input/multiple-output autoassociative networks can follow changes in plantwide behavior. The backpropagation (BPN) algorithm has been applied for training multilayer feedforward networks. A new and enhanced BPN algorithm for training neural networks has been developed and implemented in a VAX workstation. Operational data from the Experimental Breeder Reactor II (EBR-II) have been used to study the performance of the BPN algorithm. Several results of application to the EBRII are presented.
Identification of Five Serum Protein Markers for Detection of Ovarian Cancer by Antibody Arrays (2013)

Our pilot study has shown the promising set of 5 serum markers for ovarian cancer detection.
Array comparative genomic hybridization reveals genomic copy number changes associated with outcome in diffuse large B-cell lymphomas (2005)

To identify, in high-resolution regions of DNA, the copy number changes associated with outcome in patients with diffuse large B-cell lymphoma (DLBCL), a disease with an approximately 50% mortality rate, we performed array comparative genomic hybridization (array-CGH) on specimens from 64 patients with newly diagnosed DLBCL treated with anthracycline-based chemotherapy. For the entire cohort, 55 commonly gained/lost regions, ranging in size from less than 1 Mbp to entire chromosomes, were identified using 1- to 2-Mbp and 2- to 4-Mbp resolution BAC arrays. Copy number changes of 9 minimal regions significantly correlated with overall survival, of which 6 were 10 Mbp or smaller. On multivariate analysis, loss of chromosomes 2 (2.4-4.1 Mbp) and 16 (33.8-35.6 Mbp) were found to be prognostic indicators of poor survival, independent of clinical features routinely used to predict outcome. Loss of chromosome 1 (78.2-79.1 Mbp) was predictive of good outcome. For a subset of 55 specimens classified according to cell-of-origin expression signature subtype, gain of chromosome 12 (45.4-53.8 Mbp) was found to be significantly associated with the germinal center B-cell-like DLBCL subtype. Overall, array-CGH identified relatively small genomic regions associated with outcome, which, along with follow-up expression studies, may reveal target genes important in DLBCL clinical behavior.
Biomechanical and Histologic Observations of Vocal Fold Fibrous Proteins (2000)

This article discusses the molecular composition of the vocal fold and the relationship of fibrous molecules to the biomechanical and physiological performance of the tissue. The components of the extracellular matrix may be divided into fibrous proteins and interstitial proteins. The fibrous proteins, consisting of collagens and elastins, are the focus of this report. Elastin concentration varies by tissue depth in the vocal folds. Variation of elastin by age is reported, but some controversy exists. The biomechanical terms of stress and strain (and stress-strain curves of human vocal folds) are related to the fibrous proteins of the vocal folds. The fibrous proteins, their role in stress, and their effect on the dynamic range of vocal pitch are presented.
Softening of breakdown in ultra-thin gate oxide nMOSFETs at low inversion layer density (2002)

The post breakdown I-V characteristics of ultra-thin gate oxides subjected to constant voltage Fowler-Nordheim stress in nMOSFETs were investigated. It is shown that by varying the electron density through the application of a substrate bias under the same stress field conditions, the oxide degradation does not change while the oxide I-V characteristics after the breakdown event are strongly modified. We have also studied the dependence of the post-breakdown I-V curve on the current compliance used during the constant voltage stress. Finally, we speculate on the physical structure of the breakdown spot on the basis of the experimental observations.
Direct upregulation of parathyroid calcium-sensing receptor and vitamin D receptor by calcimimetics in uremic rats (2008)

To investigate whether the effect of the calcimimetic AMG 641 and calcitriol on CaSR and VDR expression could be separated from their ability to reduce parathyroid cell proliferation, five-sixth nephrectomized (5/6 Nx) rats received vehicle, AMG 641, calcitriol, or AMG 641+calcitriol either daily for 13 days (long-term protocol) or in a single dose (short-term protocol). In the long-term protocol, AMG 641, calcitriol, and their combination significantly reduced the percentage of proliferating parathyroid cells. Proliferation was uncontrolled in the short-term protocol. A significant increase in CaSR mRNA (% vs. beta-actin) was detected in rats treated with both calcitriol (1.60 +/- 0.30) and AMG 641 (1.66 +/- 0.25) for 13 days (P = 0.01 vs. 5/6 Nx+vehicle, 0.89 +/- 0.09); and there was a further increase when both drugs were administered simultaneously (2.46 +/- 0.33). In the short-term protocol, only rats receiving AMG 641 alone (2.01 +/- 0.33, P < 0.001) showed increased expression of CaSR mRNA, whereas the combination (1.81 +/- 0.20) produced no additional benefit. AMG 641 also increased CaSR mRNA expression in vitro. Changes in VDR mRNA paralleled those of CaSR mRNA. In the long-term treatment, both AMG 641 (0.87 +/- 0.14) and calcitriol (0.99 +/- 0.12) increased VDR mRNA (P < 0.05 vs. 5/6 Nx+vehicle, 0.49 +/- 0.10), and the increase was more accentuated when the drugs were combined (1.49 +/- 0.45). In the short-term protocol, only treatment with AMG 641, alone (1.52 +/- 0.41) or combined with calcitriol (1.86 +/- 0.24), increased VDR mRNA. In conclusion, our results demonstrate an acute increase in CaSR mRNA and VDR mRNA in the parathyroid glands of uremic rats treated with AMG 641, in which cell proliferation was uncontrolled, thus supporting a direct effect of calcimimetics on CaSR and VDR expression by hyperplastic parathyroid cells.
Protease-Activated Receptor 1 (PAR-1) Is Required and Rate-Limiting for Thrombin-Enhanced Experimental Pulmonary Metastasis (1998)

Thrombin-treated tumor cells induce a metastatic phenotype in experimental pulmonary murine metastasis. Thrombin binds to a unique protease-activated receptor (PAR-1) that requires N-terminal proteolytic cleavage for activation by its tethered end. A 14-mer thrombin receptor activation peptide (TRAP) of the tethered end induces the same cellular changes as thrombin. Four murine tumor cells (Lewis lung, CT26 colon CA, B16F10 melanoma, and CCL163 fibroblasts) contain PAR-1, as detected by reverse transcriptase-polymerase chain reaction (RT-PCR). B16F10 cells did not contain the two other thrombin receptors, PAR-3 and glycoprotein Ib. TRAP-treated B16F10 tumor cells enhance pulmonary metastasis 41- to 48-fold (n = 17). Thrombin-treated B16F10 cells transfected with full-length murine PAR-1 sense cDNA (S6, S7, S14, and S22) enhanced their adhesion to fibronectin 1.5- to 2.4-fold (n = 5, P <.04), whereas thrombin-treated wild-type cells do not. S6 (adhesion index, 1.5-fold) and S14 (index, 2.4-fold) when examined by RT-PCR and Northern analysis showed minimal expression of PAR-1 for S6 over wild-type and considerable expression for S14. Immunohistochemistry showed greater expression of PAR-1 for S14 compared with wild-type or empty-plasmid transfected cells. In vivo experiments with the thrombin-treated S14 transfectant showed a fivefold to sixfold increase in metastases compared with empty-plasmid transfected thrombin-treated naive cells or S6 cells (n = 20, P =.0001 to .02). Antisense had no effect on thrombin-stimulated tumor mass. Thus, PAR-1 ligation and expression enhances and regulates tumor metastasis.
Ensemble Classifiers for Steganalysis of Digital Media (2011)

Today, the most accurate steganalysis methods for digital media are built as supervised classifiers on feature vectors extracted from the media. The tool of choice for the machine learning seems to be the support vector machine (SVM). In this paper, we propose an alternative and well-known machine learning tool—ensemble classifiers implemented as random forests—and argue that they are ideally suited for steganalysis. Ensemble classifiers scale much more favorably w.r.t. the number of training examples and the feature dimensionality with performance comparable to the much more complex SVMs. The significantly lower training complexity opens up the possibility for the steganalyst to work with rich (high-dimensional) cover models and train on larger training sets—two key elements that appear necessary to reliably detect modern steganographic algorithms. Ensemble classification is portrayed here as a powerful developer tool that allows fast construction of steganography detectors with markedly improved detection accuracy across a wide range of embedding methods. The power of the proposed framework is demonstrated on three steganographic methods that hide messages in JPEG images.
Kinetics of Isotonic and Hypertonic Plasma Volume Expanders (2002)

Background Major differences in plasma volume expansion between infusion fluids are fairly well known, but there is a lack of methods that express their dynamic properties. Therefore, a closer description enabled by kinetic modeling is presented. Methods Ten healthy male volunteers received, on different occasions, a constant-rate intravenous infusion over 30 min consisting of 25 ml/kg of 0.9% saline, lactated Ringer's solution, acetated Ringer's solution, 5 ml/kg of 7.5% saline, or 3 ml/kg of 7.5% saline in 6% dextran. One-, two-, and three-volume kinetic models were fitted to the dilution of the total venous hemoglobin concentration over 240 min. Osmotic fluid shifts were considered when hypertonic fluid was infused. Results All fluids induced plasma dilution, which decreased exponentially after the infusions. The ratio of the area under the dilution-time curve and the infused fluid volume showed the following average plasma-dilution dose-effect (efficiency), using 0.9% saline as the reference (= 1): lactated Ringer's solution, 0.88; acetated Ringer's solution, 0.91; hypertonic saline, 3.97; and hypertonic saline in dextran, 7.22 ("area approach"). Another comparison, based on kinetic analysis and simulation, showed that the strength of the respective fluids to dilute the plasma by 20% within 30 min was 0.94, 0.97, 4.44, and 6.15 ("target dilution approach"). Between-subject variability was approximately half as high for the latter approach. Conclusions The relative efficiency of crystalloid infusion fluids differs depending on whether the entire dilution-time profile or only the maximum dilution is compared. Kinetic analysis and simulation is a useful tool for the study of such differences.
Reaction of α-Pinene and β-Pinene with Diethyl Hydrogen Phosphite Under Free Radical Conditions (1984)

Abstract We have found that α-pinene and β-pinene react with diethyl hydrogen phosphite (DEHP) and di-tert-butyl peroxide (TOOT) to form both mono- and diphosphonates. When the reaction was catalyzed by TOOT at 140-150[ddot]C, the major products were diphosphonates. Under comparatively mild initiation by benzoyl. peroxide at 80[ddot]C monophosphonate adducts were the major products.
Comparison of the conformations of two intact monoclonal antibodies with hinges* (1998)

Structures of two intact monoclonal antibodies were solved by X-ray diffraction analysis revealing, in both cases, the dispositions of all segments, as well as the structures of the hinge polypeptides. An IgG1, whose antigen is the drug phenobarbital, assumed a completely different conformation when compared with an IgG2a specific for canine lymphoma cells. Though neither IgG displays global two-fold symmetry, both maintain two pseudo dyad axes, one relating Fab segments, and the other the halves of the Fc. In both IgGs, the Fc segment is obliquely disposed with respect to the plane of the Fabs, making an angle of 128 degrees in the IgG2a, and 107 degrees in the IgG1. Hinge angles of the IgG1 are notably different at 78 degrees and 123 degrees, and unique as well from IgG2a values of 66 degrees and 113 degrees. Elbow angles within the IgG1 Fabs are the same at 155 degrees, but non-identical in IgG2a where they took on values of 143 degrees and 159 degrees. The IgG2a has an angle of 172 degrees between Fabs so that it exhibits a "distorted T" shape, whereas that angle in the IgG1 is a much more acute 115 degrees producing a "distorted Y". CH2 domains appear, in both antibodies, to be the most independently mobile of the paired IgG domains. This perhaps reflects their importance in modulating effector functions through exposure of binding loci on the CH2, at the CH2-CH3 interface, and on lower hinge polypeptides. Hinges in both antibodies contain disulfide-linked cores bounded by fluid regions above and below, which provide mobility to the Fabs and Fc respectively. The conformations seen in these two structures are undoubtedly only two among many but they illustrate the modes of flexibility inherent to the IgG architecture.
Host Susceptibility to the Attaching and Effacing Bacterial PathogenCitrobacter rodentium (2003)

Many studies have shown that genetic susceptibility plays a key role in determining whether bacterial pathogens successfully infect and cause disease in potential hosts. Surprisingly, whether host genetics influence the pathogenesis of attaching and effacing (A/E) bacteria such as enteropathogenic and enterohemorrhagic Escherichia coli has not been examined. To address this issue, we infected various mouse strains with Citrobacter rodentium, a member of the A/E pathogen family. Of the strains tested, the lipopolysaccharide (LPS) nonresponder C3H/HeJ mouse strain experienced more rapid and extensive bacterial colonization than did other strains. Moreover, the high bacterial load in these mice was associated with accelerated crypt hyperplasia, mucosal ulceration, and bleeding, together with very high mortality rates. Interestingly, the basis for the increased susceptibility was not due to LPS hyporesponsiveness, as the genetically related but LPS-responsive C3H/HeOuJ and C3H/HeN mouse strains were also susceptible to infection. Analysis of the intestinal pathology in these susceptible strains revealed significant crypt epithelial cell apoptosis (terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end label staining) as well as bacterial translocation to the mesenteric lymph nodes. Further studies with infection of SCID (T- and B-lymphocyte-deficient) C3H/HeJ mice demonstrated that loss of lymphocytes had no effect on bacterial numbers but did reduce crypt cell apoptosis and delayed mortality. These studies thus identify the adaptive immune system, crypt cell apoptosis, and bacterial translocation but not LPS responsiveness as contributing to the tissue pathology and mortality seen during C. rodentium infection of highly susceptible mouse strains. Determining the basis for these strains' susceptibility to intestinal colonization by an A/E pathogen will be the focus of future studies.
Leakage mechanism due to floating body and countermeasure on dynamic retention mode of SOI-DRAM (2002)

SOI-DRAM is expected to have long data retention time because the data leakage path is limited only through a cell transistor. High speed low power operation is realized due to reduced junction capacitances. Moreover, since the capacitance ratio Cb/Cs is reduced, the read out signal amplitude increases. For these reasons SOI is well suited to low power supply voltage DRAMs. However, because SOI uses body-floating transistors for memory cells, there is a possibility that majority carriers within the floating body can cause problems. To date, only the static data retention characteristics have been reported, with nothing written about the dynamic data retention characteristics for full DRAM operation. This paper details the results of an analysis of the floating body caused leakage mechanism and its effect on dynamic data retention. A proposal is made to obtain superior dynamic data retention time.
Continuum Manipulator Statics Based on the Principle of Virtual Work (2012)

This paper presents a generalized method of determining the static shape conformation of a continuum robot based on the principle of virtual work. A lumped parameter model is utilized to model a prototypical single-segment manipulator. Elastic effects, gravitational forces and actuation loading are modeled as generalized forces and moments acting along the manipulators at discrete masses. A brief derivation of the governing static equations based on the principle of virtual work is presented, and then applied to the problem of continuum manipulator statics. The numerical method was successfully implemented numerically, capable of determining a system’s static equilibrium given a prescribed actuation.
Adaptive Distance Estimation Based on RSSI in 802.15.4 Network (2013)

This paper deals with the distance estimation issue in 802.15.4 wireless sensor networks. On a basis of signal strength of received frames a distance between two sensor nodes using the log-normal shadowing radio propagation model (LNSM) is estimated. Basic problems of signal strength based systems are variation of RSSI parameter and correct calibration of coefficients for the LNSM model. For distance estimation in wireless networks, static and dynamic methods of calibration were already introduced. Static calibration has significant drawback in adaptation to the dynamical environment changes. Proposed work deals with an experimental validation of dynamic calibration method for distance estimation in wireless sensor networks. This method for dynamic estimation of radio environment parameters results in the significant improvements in the distance estimation accuracy in comparison with the known static methods.
Participation of Na,K-ATPase in FGF-2 Secretion:  Rescue of Ouabain-Inhibitable FGF-2 Secretion by Ouabain-Resistant Na,K-ATPase α Subunits (2000)

We have examined the relationship between Na,K-ATPase and FGF-2 secretion in transfected primate cells. FGF-2 lacks a classic hydrophobic export signal, and the mechanisms mediating its secretion are unknown. To monitor secretion, a FLAG epitope tag was inserted into the carboxyl terminus of the 18 kDa form of human FGF-2, and the construct was transfected into either human HEK 293 or monkey CV-1 cells. Exported FGF-2 was detected in the culture medium using the FLAG-specific monoclonal antibody M2. FGF-2 secretion from HEK 293 or CV-1 cells was linear over time and sensitive to inhibition by the cardiac glycoside ouabain, a specific inhibitor of the Na,K-ATPase. In contrast, the secretion of FGF-8 (an FGF family member that contains a hydrophobic secretory signal) was not inhibited by treatment of HEK 293 or CV-1 cells with ouabain. FGF-2 secretion was also assayed in CV-1 cells expressing the naturally ouabain-resistant rodent Na,K-ATPase alpha1 subunit. In cells expressing the rodent alpha1 subunit, FGF-2 secretion was unaffected by high levels of ouabain, indicating that the rodent alpha1 subunit was capable of rescuing ouabain-inhibitable FGF-2 export. Expression of ouabain-resistant mutants of the rodent alpha2 and alpha3 subunits, or the naturally ouabain-resistant rodent alpha4 subunit, also supported FGF-2 secretion in ouabain-treated cells. Taken together, our studies are consistent with the idea that the Na,K-ATPase plays a prominent role in regulating FGF-2 secretion, although none of the alpha subunit isoforms exhibited specificity with regard to FGF-2 export.
An aural user interface for ubiquitous computing (2003)

Ubiquitous computing systems make it possible for people to access computing resources whenever and from wherever they want. To take advantage of this capability, the user must be able to make queries, perform computations, and generally operate the system at times and in situations that may be incompatible with restrictions imposed by current interfaces. In this paper, we present a novel user interface, discuss its qualities, and compare and contrast it with existing methods.