gebhart/patrepeval huggingface dataset:
Preparation and Properties of an Analogue of Poly(A) and Poly(G): Poly(isoguanylic acid) (1976)

Isoguanosine-5'-pyrosphosphate, in the presence of an oligonucleotide primer, was polymerized by Escherichia coli polynucleotide phosphorylase under conditions analogous to those required for polymerization of 5'-GMP. The resulting poly(isoguanylic acid), poly(isoG), was a multistranded helix with a stability considerably higher than that of poly(G), and fully resistant to various nucleolytic enzymes. The polymer exhibited a two-step temperature transition profile in moderately alkaline propylene glycol. Alkaline titration in aqueous medium, by ultraviolet and circular dichroism spectroscopy, showed two clearly defined transitions, the second of which was fully cooperative. The accompanying changes in sedimentation constants were consistent with a structure for poly(isoG) of a fourstranded helix, like neutral poly(G). In acid medium, spectral and potentiometric titrations demonstrated the existence of more than one transition in the pH range 6-12, with accompanying protonation of the isoguanosine residues. In neutral medium the polymer formed no complexes with other potentially complementary homopolymers. In acid medium, on the other hand, the protonated form of poly(isoG) did form a triple-stranded complex with poly(I), viz. 2poly(I) . poly(isoG)+. Possible structures are formulated for the neural and protonated forms of poly(isoG) which account for the two-step thermal transition in alkaline propylene glycol and on alkaline titration in aqueous medium. The nature of the protonated form, and its complex with poly(I) is also discussed.
Uranium Extraction from Phosphoric Acid Using Bifunctional Amido-Phosphonic Acid Ligands (2014)

Ligand systems containing amido-phosphonic acid moieties were synthesized for subsequent U(VI) extraction from phosphoric acid solutions. Studies have shown that the efficiency of extraction (distribution ratios and selectivity of U(VI) over Fe(III)) is influenced by the nature of the N-dialkyl substituents and the length and nature of the spacer. A structure-activity approach resulted in the identification of a specific ligand called DEHCBPA that exhibited larger D-values than the corresponding URPHOS reference system. The distribution ratios for U(VI) extraction increased considerably with a branched N-dialkyl chain when a steric hindrance was introduced into the methylene bridge of the amido-phosphonic acid ligands.
The Role of cccDNA in HBV Maintenance (2017)

Chronic hepatitis B virus (HBV) infection continues to be a major health burden worldwide; it can cause various degrees of liver damage and is strongly associated with the development of liver cirrhosis and hepatocellular carcinoma. The molecular mechanisms determining HBV persistence are not fully understood, but these appear to be multifactorial and the unique replication strategy employed by HBV enables its maintenance in infected hepatocytes. Both the stability of the HBV genome, which forms a stable minichromosome, the covalently closed circular DNA (cccDNA) in the hepatocyte nucleus, and the inability of the immune system to resolve chronic HBV infection are believed to be key mechanisms of HBV chronicity. Since a true cure of HBV requires clearance of intranuclear cccDNA from infected hepatocytes, understanding the mechanisms involved in cccDNA biogenesis, regulation and stability is mandatory to achieve HBV eradication. This review will summarize the state of knowledge on these mechanisms including the impact of current treatments on the cccDNA stability and activity. We will focus on events challenging cccDNA persistence in dividing hepatocytes.
&lt;title&gt;Electrical measurements for monitoring and control of rf plasma processing&lt;/title&gt; (1993)

We have investigated the possibility of using current and voltage measurements for real-time monitoring and control of radio-frequency discharges. Specifically, we have equipped a gaseous electronics conference (GEC) rf reference cell with a computer-controlled measurement system that samples the voltage and current waveforms at the cell power input and Fourier analyzes these waveforms to obtain the amplitude and phase of their fundamental and harmonic components. The system accounts for errors introduced by the stray impedance of the cell, yielding corrected values that more accurately reflect the values of voltage and current at electrode surfaces in contact with the plasma. These corrected values are monitored to reveal changes in fundamental plasma parameters such as sheath voltages, sheath fields, and sheath (dark space) thicknesses. Furthermore, the corrected values serve as better control parameters than the raw values of voltage, current or power, measured externally. The time required for the acquisition and analysis of a pair of current and voltage waveforms is approximately one second, making these measurements suitable for real-time sensing and control applications.
Antitumor activity of platinum(II) complexes of 1,2-diamino-cyclohexane isomers. (1980)

Dichloro, dibromo, oxalato, malonato, dinitrato, sulfato and mono and bis-(D-glucuronato) platinum(II) complexes of 1,2-diaminocyclohexane (dach) isomers were prepared and tested on L1210 mouse leukemia employing the NCI protocol for evaluation of Pt analogs. A large number of long-term survivors were observed with certain analogs, though the therapeutic indices (optimal dose/minimum effective dose) were not large. Among the analogs tested, the oxalato, malonato, dinitrato and mono-(D-glucuronato) Pt(II) complexes of trans-1,2-diaminocyclohexane were found to be particularly effective. The glucuronato Pt complexes appear to be promising candidates for clinical trial since they have the highest solubility in water.
Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e (1978)

Five previously unknown hemorrhagic proteins, designated hemorrhagic toxins a,b,c,d, and e, were isolated from the venom of the western diamondback rattlesnake (Crotalus atrox). Molecular weights of hemorrhagic toxins a-e were determined to be 68 000, 24 000, 24 000, 24 000, and 25 700, respectively, by sodium dodecyl sulfate-phosphate gel electrophoresis using various polyacrylamide gel concentrations. Amino acid composition showed a total of 636, 200, 213, 214, and 219 amino acids for hemorrhagic toxins a-e, respectively. All the hemorrhagic toxins were found to lose their hemorrhagic activities with the metal chelators ethylenediaminetetraacetic acid and 1, 10-phenanthroline. All the hemorrhagic toxins were found to contain approximately 1 mol of zinc/mol of toxin, and they were all demonstrated to be proteolytic when dimethylcasein and dimethylhemoglobin were used as substrates. When zinc was removed from hemorrhagic toxin e with 1,10-phenanthroline, both both the proteolytic and hemorrhagic activities were equally inhibited. When the apohemorrhagic toxin e thus produced was incubated with zinc, the hemorrhagic and proteolytic activities were regenerated to the same extent. CD, UV, and Raman spectroscopy were used to study the structure of native hemorrhagin toxin e as well as the structural changes caused by zinc removal. From CD spectroscopy the native toxin was estimated to consist of 23% alpha helix, 6% beta structure, and 71% random-coil conformation. When over 90% of the zinc was removed, the alpha-helix content dropped from 23 to 7%.
Serum and nasal-wash immunoglobulin G and A antibody response of infants and children to respiratory syncytial virus F and G glycoproteins following primary infection (1986)

An enzyme-linked immunosorbent assay (ELISA) with immunoaffinity-purified fusion (F) or attachment (G) glycoprotein was used to measure the serum and secretory immune responses of 18 infants and children, 4 to 21 months of age, who underwent primary infection with respiratory syncytial virus (RSV). Most of the 10 older individuals (9 to 21 months of age) developed moderate levels of serum and nasal-wash immunoglobin A (IgA) and IgG F and G antibodies. These individuals developed a moderate level of serum or nasal-wash antibodies that neutralized virus infectivity. One of the eight younger individuals (4 to 8 months of age) failed to develop an F antibody response, while three failed to develop a G antibody response. The most notable difference in the responses of the two age groups involved the titer in convalescent sera of G, F, and neutralizing antibodies which were 8- to 10-fold lower in younger individuals. Most of the younger infants failed to develop a rise in serum or nasal-wash neutralizing antibody. It is possible that the presence of maternally derived antibody in the younger infants suppressed the immune response to RSV infection, and that this accounted, in part, for the low level of postinfection antibody titer in this group. This low level and the irregular response of the infants less than 8 months of age may contribute to the severity of their initial infection and may also be responsible, in part, for their failure to develop effective resistance to subsequent reinfection by RSV.
Enantiospecific Synthesis of 5′-Noraristeromycin and its 7-Deaza Derivative and A Formal Synthesis of (-)-5′-Homoaristeromycin (1993)

Abstract Beginning with the treatment of the diacetate of cis-3,5-cyclopentenediol (5) with Pseudomonas cepacia lipase, (-)-5′-noraristeromycin (1) and (-)-7-deaza 5′-noraristeromycin (3) have been prepared. Subjecting 5 to treatment with porcine liver esterase led to an efficient preparation of a substituted cyclopentane precursor which, following literature precedence, can be converted into (-)-5′-homoaristeromycin (4).
폐경 전, 폐경 후 여성의 혈청 25-hydroxyvitamin D 수준과 대사증후군 위험도의 관계 (2012)

Metabolic syndrome (MetS) has become a global epidemic. In particular, it is known that there is a dramatic increase in the prevalence of MetS among women during the postmenopausal period. Recently, accumulating studies have suggested that vitamin D deficiency may be inversely associated with the risk factors regarding MetS. However, evidence from postmenopausal women is limited. In this study, we examined the association between the serum 25-hydroxyvitamin D [25(OH)D] and the MetS in Korean adult women aged 20-69 years (n = 2,618) by using the 2007-2008 Korean National Health and Nutrition Examination Survey data. The geometric mean of plasma 25(OH)D were 17.16 ± 6.28 ng/㎖ and 20.20 ± 7.69 ng/㎖ for premenopausal and postmenopausal women, respectively. The percentages of vitamin D deficiency [25(OH)D ＜ 12 ng/㎖] were 22.5% and 14.4%, respectively. MetS was more prevalent in postmenopausal women (43.0%) compared with premenopausal women (11.2%). When serum concentrations of 25(OH)D were categorized in quintiles, there was no relationship in the prevalence of MetS in both premonopausal and postmenopausal women. However, in premenopausal women, compared with the lowest 25(OH)D quintile, the odds ratio for hypertriglyceridemia in the highest quintile was 0.57 (95% CI 0.34-0.95, P trend = 0.041) and for low serum HDL cholesterol 0.60 (95% CI 0.42-0.85, P trend = 0.014) after adjusting for all potential confounders. On the other hand, we observed the tendency of an inverse relationship for 25(OH)D regarding low serum HDL cholesterol (OR 0.78, 95% CI 0.50-1.22, P trend = 0.029) and a direct relationship with abdominal obesity (OR 1.94, 95% CI 1.01, 3.74, P trend = 0.049) in postmenopausal women. Further studies are needed to confirm these findings in other research settings.
USEFUL CHIRAL PACKING MATERIALS FOR HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC RESOLUTION. CELLULOSE TRIACETATE AND TRIBENZOATE COATED ON MACROPOROUS SILICA GEL (1984)

Abstract Cellulose triacetate and tribenzoate coated on macroporous silica gel showed excellent capabilities of chiral recognition as packing materials for high-performance liquid chromatographic resolution of various enantiomers. Chiral recognition by the cellulose triacetate was different from that by the microcrystalline cellulose triacetate.
Locally connected VLSI architectures for the Viterbi algorithm (1988)

The Viterbi algorithm is a well-established technique for channel and source decoding in high-performance digital communication systems. Implementations of the Viterbi algorithm on three types of locally connected processor arrays are described. The restriction is motivated by the fact that both the cost and performance metrics of VLSI favour architectures in which on-chip interprocessor communication is localized. Each of the structures presented can accommodate arbitrary alphabet sizes and algorithm memory lengths.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The electron impact induced fragmentation of geminal dialkanoates (1977)

Abstract The mass spectra of representative 1,1‐dicarboxylates have been studied in order to identify fragmentation patterns typical of such compounds and thus to aid their characterization in complex mixtures. Two typical decomposition pathways were noted. One invoves the loss of a carboxylate group, and the other the ejction of an sliphatic sidechain. It is suggested that a similar gragmentation scheme is to be expected of the much more labile dialkanoates derived from ketones.
Degenerate four-wave mixing near the band gap of semiconductors (1979)

We present a theoretical calculation and experimental data on the effective third-order susceptibilities χ(3) for degenerate four-wave mixing near the band gap of semiconductors. The closeness of the calculated and experimental values for the effective χ(3) in silicon at 1.06 μm indicates the utility of our simple calculation. The large values of χ(3) indicate the possibility of high-efficiency degenerate four-wave mixing in semiconductors, especially at longer wavelengths.
Optical-Sideband Cooling of Visible Atom Cloud Confined in Parabolic Well (1978)

An assemblage of < 50 Ba+ ions, contained in a parabolic well, has been visually observed and cooled by means of near-resonant laser irradiation.Received 25 April 1978DOI:https://doi.org/10.1103/PhysRevLett.41.233©1978 American Physical Society
Anomalous C-V characteristics of implanted poly MOS structure in n/sup +//p/sup +/ dual-gate CMOS technology (1989)

The C-V characteristics of arsenic-doped polysilicon show a gate-bias dependence of the inversion capacitance and a reduction in the expected value of the inversion capacitance. The characteristics have been investigated with quasistatic and high-frequency C-V as well as conductance measurements of various capacitors that have been subjected to annealing times and temperatures ranging from 900 degrees C/30 min to rapid thermal annealing at 1050 degrees C. The results can be explained by assuming that there is a depletion region forming in the polysilicon due to insufficient activation of the dopant at the polysilicon/oxide surface. The impact of this condition on the device characteristics is shown to be a 20-30% reduction in the G/sub m/ of NMOS transistors with 125-AA Gate oxide thickness.
Simple radix 2 division and square root with skipping of some addition steps (2002)

The authors present a novel algorithm for shared radix 2 division and square root whose main characteristic is the ability to avoid any addition when the digit 0 has been selected. The solution presented uses a redundant representation of the partial remainder, while keeping the advantages of classical solutions. It is shown how the next digit of the result can be selected even when the remainder is not updated; the tradeoff arising is also indicated. The average occurrences of 0 digit selections are also estimated in order to assess the benefits of the algorithm presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
MIDTERM RESULTS OF LOW-DOSE INTRAVITREAL TRIAMCINOLONE AS ADJUNCTIVE TREATMENT FOR PROLIFERATIVE VITREORETINOPATHY (2011)

Low-dose (2 mg) triamcinolone acetonide intravitreal injection as an adjunct to vitrectomy and silicone oil tamponade in treating proliferative vitreoretinopathy (grade C or D) appears to be effective and safe.
Predominant cerebral cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T cell therapy (2016)

ChiCTR-OCC-15007008 .
Phosphorylation of the VirG protein of Agrobacterium tumefaciens by the autophosphorylated VirA protein: essential role in biological activity of VirG (1990)

Agrobacterium tumefaciens virulence genes are induced by plant signals through the VirA-VirG two-component regulatory system. The VirA protein is a membrane-spanning sensor molecule that possesses an autophosphorylating activity, and the VirG protein is a sequence-specific DNA-binding protein. In this report, we demonstrate that the VirG protein is phosphorylated by the VirA protein and that the phosphate is directly transferred from the phosphorylated VirA molecule (phosphohistidine) to the VirG protein. The chemical stability of the phospho-VirG bond suggested that the VirG protein was phosphorylated at the aspartate and/or glutamate residue. The phosphorylated VirG protein was reduced with tritiated sodium borohydride and subjected to proteolytic digestion with the Achromobacter protease I enzyme. The resulting peptide fragments were separated by C8 reversed-phase high-pressure liquid chromatography, and the tritium-labeled peptide was sequenced. Amino acid sequence data showed that the aspartate residue at position 52 was the only site phosphorylated. Changing this aspartate into asparagine resulted in a nonphosphorylatable and biologically nonfunctional gene product. As a control, a randomly chosen aspartate was changed into an asparagine (position 72), and no effect on its phosphorylation or biological activity was observed. Unlike its homologs, including CheA-CheY, EnvZ-OmpR, and NtrB-NtrC, the phospho-VirG molecule was very stable in vitro. The possible implications of these observations and the function of VirG phosphorylation in vir gene activation are discussed.
The self-propagating high-temperature synthesis of sinterable powders (1993)

The present overview focuses on self-propagating high-temperature synthesis (SHS) of powders for the standard processing of ceramics by sintering or hot-pressing. An impact of SHS on ceramic materials technology depends largely on its capability to produce powders that have a densification behaviour comparable to or better than the conventionally produced ones. The paper points to the fact that substitution of the conventional powders by the SHS-derived ones results in higher density and more homogeneous microstructure, at least with nitride and carbide powders that are notorious for their bad sinterability. The first part of the paper deals with the general features of SHS. The specific mechanism of SHS reactions is the object of the second part of the paper. Part three of the paper presents the sintering characteristics of powders produced by SHS in the Si-C-B, Si-N, Si-Al-O-N, and Ti-C-Si systems.
Carbon dioxide activation by lithium metal. 1. Infrared spectra of lithium carbon dioxide (Li+CO2-), lithium oxalate (Li+C2O4-), and lithium carbon dioxide (Li22+CO22-) in inert-gas matrices (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon dioxide activation by lithium metal. 1. Infrared spectra of lithium carbon dioxide (Li+CO2-), lithium oxalate (Li+C2O4-), and lithium carbon dioxide (Li22+CO22-) in inert-gas matricesZ. H. Kafafi, R. H. Hauge, W. E. Billups, and J. L. MargraveCite this: J. Am. Chem. Soc. 1983, 105, 12, 3886–3893Publication Date (Print):June 1, 1983Publication History Published online1 May 2002Published inissue 1 June 1983https://pubs.acs.org/doi/10.1021/ja00350a025https://doi.org/10.1021/ja00350a025research-articleACS PublicationsRequest reuse permissionsArticle Views786Altmetric-Citations105LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Compound document transfer between electronic-mail network and facsimile terminals (1990)

The authors present a system for combining the two related yet separated modes of electronic document transfer, namely, electronic-mail (E-mail) and facsimile. Messages prepared at desk-top terminals, supporting compound document creation and editing, and submitted to the E-mail network can thus be received by both interconnected terminals in the common E-mail architecture and by facsimile terminals connected to the public switched telephone networks (PSTN). The latter transmission is achieved by facsimile gateways which connect the two different architectures and perform the necessary protocol conversions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>