gebhart/patrepeval huggingface dataset:
Brassey's Encyclopedia of Land Forces and Warfare (1997)

A compilation of articles made from the International Military and Defense Encyclopedia (IMADE), written by international military experts, this volume includes more than 130 articles on combat theory and operations, leadership, land forces and warfare, logistics, manpower and personnel, material and weapons, technology, military law and intelligence.
Substance Abuse and the Disorders of the Self: (1993)

This article presents significant findings from descriptive, psychodynamic, and developmental research and a recent study supporting the existence of a strong positive relationship between substance abuse and the characterological/personality disorders and/or "disorders of the self." Fifty alcoholics/addicts were assessed utilizing the Millon Clinical Multiaxial Inventory (MCMI) 3 to 5 days prior to discharge from an inpatient chemcial dependency unit. Results indicated that 50 to 70% of the subjects were likely suffering from comorbid "disorders of the self." Implications of the findings are discussed and treatment suggestions offered including increased emphasis on spirituality, individual psychotherapy, and matching of treatment to patient needs.
A functional heteromeric MIF receptor formed by CD74 and CXCR4 (2009)

MIF is a chemokine-like inflammatory mediator that triggers leukocyte recruitment by binding to CXCR2 and CXCR4. MIF also interacts with CD74/invariant chain, a single-pass membrane-receptor. We identified complexes between CD74 and CXCR2 with a role in leukocyte recruitment. It is unknown whether CD74 also binds to CXCR4. We demonstrate that CD74/CXCR4 complexes formed when CD74 was expressed with CXCR4 in HEK293 cells. Expression of CD74-variants lacking an ER-retention signal showed CD74/CXCR4 complexes at the cell surface. Importantly, endogenous CD74/CXCR4 complexes were isolated by co-immunoprecipitation from monocytes. Finally, MIF-stimulated CD74-dependent AKT activation was blocked by anti-CXCR4 and anti-CD74 antibodies and AMD3100, whereas CXCL12-stimulated AKT activation was not reduced by anti-CD74. Thus, CD74 forms functional complexes with CXCR4 that mediate MIF-specific signaling.
Color image segmentation using modified HSI system for road following (2002)

A novel method for outdoor natural color image segmentation for road following is presented. From the results of experiments it can be seen that the hue, saturation, and intensity (HSI) system should be used rather than the red, green, blue (RGB) system, and segmentation can be done in S-I space with good performance. An automatic adaptive threshold selection method is developed. The preliminary results indicate the effectiveness and efficiency of this method.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Prognostic value of nuclear grade of renal cell carcinoma (1995)

In this study, nuclear grade was found to have prognostic significance and seems to be an important criterion when considering the outcome of patients with RCC.
Most Bothersome Symptom in Persons With Migraine: Results From the Migraine in America Symptoms and Treatment (MAST) Study (2019)

Most people with migraine in the MAST observational study reported all 3 cardinal symptoms of nausea, photophobia, and phonophobia. As in clinical trials, the most common MBS was photophobia. Patient profiles differed among the groups defined by their MBS.
Facile synthesis of well-defined water-soluble polymers via atom transfer radical polymerization in aqueous media at ambient temperature (1999)

Monomethoxy-capped oligo(ethylene oxide) methacrylate (OEGMA) is readily polymerised in aqueous media by atom transfer radical polymerisation at 20 °C using various initiators; the resulting OEGMA polymers and macromonomers were obtained in high yield (>95%) within short reaction times and polydispersities were as low as 1.12.
Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis. (1994)

Anti-CD4 treatment is reported to prevent collagen-induced arthritis if administered before the onset of clinical disease but has relatively little effect on established arthritis. In contrast, we have recently shown that anti-tumor necrosis factor alpha/beta (TNF) treatment reduces the severity of established arthritis. We now study the effect of combined administration of anti-CD4 monoclonal antibody (YTS 191.1.2/YTA 3.1.2) and anti-TNF monoclonal antibody (TN3-19.12) in established arthritis. Anti-CD4 treatment caused some reduction in paw-swelling but did not significantly prevent joint erosion. A suboptimal dose of anti-TNF alone had no significant effect on arthritis. In contrast, anti-CD4 plus suboptimal anti-TNF significantly reduced paw-swelling, limb involvement, and joint erosion. As previously reported, an optimal dose of anti-TNF alone inhibited paw-swelling, limb involvement, and joint erosion. However, optimal anti-TNF combined with anti-CD4 caused significantly greater reductions in paw-swelling and joint erosion than those achieved by optimal anti-TNF alone. Coadministration of anti-CD4 was also effective in preventing an antibody response to the hamster anti-TNF antibody, which may have implications for long-term therapy in human disease. Thus anti-CD4 acts synergistically with anti-TNF in ameliorating established collagen-induced arthritis and this combined therapeutic approach may provide effective long-term control of rheumatoid arthritis.
Fathering Roles, Responsibilities and Barriers - Men Speak Out (2003)

This section discuses the various aspects involved in the role of good fathering, through an analysis of the 'Focus on Fathering Project' that aims to develop the knowledge base on fatherhood in Australia, specifically from a father's perspective.
Botulism (2005)

Botulism is a rare disease with 4 naturally occurring syndromes: foodborne botulism is caused by ingestion of foods contaminated with botulinum toxin, wound botulism is caused by Clostridium botulinum colonization of a wound and in situ toxin production, infant botulism is caused by intestinal colonization and toxin production, and adult intestinal toxemia botulism is an even rarer form of intestinal colonization and toxin production in adults. Inhalational botulism could result from aerosolization of botulinum toxin, and iatrogenic botulism can result from injection of toxin. All forms of botulism produce the same distinct clinical syndrome of symmetrical cranial nerve palsies followed by descending, symmetric flaccid paralysis of voluntary muscles, which may progress to respiratory compromise and death. The mainstays of therapy are meticulous intensive care (including mechanical ventilation, when necessary) and timely treatment with antitoxin.
Collaborative Policies and Assured Information Sharing (2013)

Abstract : Privacy has become a significant concern in modern society as personal information about individuals is increasingly collected, used, and shared, often using digital technologies, by a wide range of organizations. To mitigate privacy concerns, organizations are required to respect privacy laws in regulated sectors (e.g., HIPAA in healthcare, GLBA in financial sector) and to adhere to self-declared privacy policies in self-regulated sectors (e.g., privacy policies of companies such as Google and Facebook in Web services). We investigate the possibility of formalizing and enforcing such practical privacy policies using computational techniques. We formalize privacy policies that prescribe and proscribe flows of personal information. Recognizing that traditional preventive access control and information flow control mechanisms are inadequate for enforcing such privacy policies, we develop principled audit and accountability mechanisms that seek to encourage policy-compliant behavior by detecting policy violations, assigning blame, and punishing violators. We apply these techniques to several U.S. privacy laws and organizational privacy policies, in particular, producing the first complete logical specification and audit of all disclosure-related clauses of the HIPAA Privacy Rule.
Improving Cost, Performance, and Security of Memory Encryption and Authentication (2006)

Protection from hardware attacks such as snoopers and mod chips has been receiving increasing attention in computer architecture. This paper presents a new combined memory encryption/authentication scheme. Our new split counters for counter-mode encryption simultaneously eliminate counter overflow problems and reduce per-block counter size, and we also dramatically improve authentication performance and security by using the Galois/Counter Mode of operation (GCM), which leverages counter-mode encryption to reduce authentication latency and overlap it with memory accesses. Our results indicate that the split-counter scheme has a negligible overhead even with a small (32KB) counter cache and using only eight counter bits per data block. The combined encryption/authentication scheme has an IPC overhead of 5% on average across SPEC CPU 2000 benchmarks, which is a significant improvement over the 20% overhead of existing encryption/authentication schemes.
USO DE FIPRONIL SPRAY NO TRATAMENTO DA ESCABIOSE CANINA (2005)

O objetivo deste trabalho foi comprovar a eficacia do fipronil spray (FRONTLINEâ), uma nova molecula sintetica, como acaricida seguro em caes. Foram analisados 10 caes provenientes do atendimento do servico de Dermatologia do Hospital Veterinario e do canil da UNOESTE, Presidente Prudente, SP, com quadro sintomatico e raspado de pele positivo para escabiose, e utilizado o fipronil spray em todo o corpo do animal, inclusive pavilhao auditivo, semanalmente ate o desaparecimento dos sintomas e raspado de pele negativo para escabiose. A remissao dos sintomas conjuntamente com o raspado de pele negativo ocorreu em media de 4 a 6 semanas, demonstrando ser o fipronil spray eficaz, e pratico, podendo ser uma alternativa segura no tratamento da escabiose canina.
Synthesen des 4‐Amino‐3‐isoxazolidinons (Cycloserin) und einiger Analoga (1957)

Abstract Stereospecific syntheses of cycloserine ( D ‐4‐amino‐3‐isoxazolidinone) are described. The same synthetic methods lead to some 5‐substituted 4‐amino‐3‐isoxazolidinones. The stereochemical relationship of these compounds to the parent amino acids is discussed.
Adipose Tissue as an Endocrine Organ (2004)

Adipose tissue is a complex, essential, and highly active metabolic and endocrine organ. Besides adipocytes, adipose tissue contains connective tissue matrix, nerve tissue, stromovascular cells, and immune cells. Together these components function as an integrated unit. Adipose tissue not only responds to afferent signals from traditional hormone systems and the central nervous system but also expresses and secretes factors with important endocrine functions. These factors include leptin, other cytokines, adiponectin, complement components, plasminogen activator inhibitor-1, proteins of the renin-angiotensin system, and resistin. Adipose tissue is also a major site for metabolism of sex steroids and glucocorticoids. The important endocrine function of adipose tissue is emphasized by the adverse metabolic consequences of both adipose tissue excess and deficiency. A better understanding of the endocrine function of adipose tissue will likely lead to more rational therapy for these increasingly prevalent disorders. This review presents an overview of the endocrine functions of adipose tissue.
BRCTx Is a Novel, Highly Conserved RAD18-Interacting Protein (2005)

The BRCT domain is a highly conserved module found in many proteins that participate in DNA damage checkpoint regulation, DNA repair, and cell cycle control. Here we describe the cloning, characterization, and targeted mutagenesis of Brctx, a novel gene with a BRCT motif. Brctx was found to be expressed ubiquitously in adult tissues and during development, with the highest levels found in testis. Brctx-deficient mice develop normally, show no pathological abnormalities, and are fertile. BRCTx binds to the C terminus of hRAD18 in yeast two-hybrid and immunoprecipitation assays and colocalizes with this protein in the nucleus. Despite this, Brctx-deficient murine embryonic fibroblasts (MEFs) do not show overt sensitivity to DNA-damaging agents. MEFs from Brctx-deficient embryos grow at a similar rate to wild-type MEF CD4/CD8 expressions, and the cell cycle parameters of thymocytes from wild-type and Brctx knockout animals are indistinguishable. Intriguingly, the BRCT domain of BRCTx is responsible for mediating its localization to the nucleus and centrosome in interphase cells. We conclude that, although highly conserved, Brctx is not essential for the above-mentioned processes and may be redundant.
Cellulose Derivatives (1998)

Novel solvent systems for cellulose are reviewed in terms of their potential for supporting chemical modification reactions that lead to highly engineered derivatives. Systems capable of sustaining homogeneous phase conditions include (1) dissolution with non-derivatizing solvents; (2) dissolution with partial derivatization with reactive solvents; (3) dissolution by derivatization with protective substituents; and (4) dissolution by derivatization with solubilizing substituents that provide access to subsequent replacement reactions (ie., leaving groups). Numerous examples and applications are cited for each type of homogeneous phase reaction system.
Targeting a Surface Cavity of α1-Antitrypsin to Prevent Conformational Disease (2003)

Conformational diseases are caused by a structural rearrangement within a protein that results in aberrant intermolecular linkage and tissue deposition. This is typified by the polymers that form with the Z deficiency variant of alpha 1-antitrypsin (Glu-342 --> Lys). These polymers are retained within hepatocytes to form inclusions that are associated with hepatitis, cirrhosis, and hepatocellular carcinoma. We have assessed a surface hydrophobic cavity in alpha1-antitrypsin as a potential target for rational drug design in order to prevent polymer formation and the associated liver disease. The introduction of either Thr-114 --> Phe or Gly-117 --> Phe on strand 2 of beta-sheet A within this cavity significantly raised the melting temperature and retarded polymer formation. Conversely, Leu-100 --> Phe on helix D accelerated polymer formation, but this effect was abrogated by the addition of Thr-114 --> Phe. None of these mutations affected the inhibitory activity of alpha 1-antitrypsin. The importance of these observations was underscored by the finding that the Thr-114 --> Phe mutation reduced polymer formation and increased the secretion of Z alpha 1-antitrypsin from a Xenopus oocyte expression system. Moreover cysteine mutants within the hydrophobic pocket were able to bind a range of fluorophores illustrating the accessibility of the cavity to external agents. These results demonstrate the importance of this cavity as a site for drug design to ameliorate polymerization and prevent the associated conformational disease.
New method for the synthesis of optically active .alpha.-amino acids and their N.alpha. derivatives via acylamino malonates (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew method for the synthesis of optically active .alpha.-amino acids and their N.alpha. derivatives via acylamino malonatesArieh Berger, Moshe Smolarsky, Nurith Kurn, and Hans Rudolf BosshardCite this: J. Org. Chem. 1973, 38, 3, 457–460Publication Date (Print):February 1, 1973Publication History Published online1 May 2002Published inissue 1 February 1973https://pubs.acs.org/doi/10.1021/jo00943a009https://doi.org/10.1021/jo00943a009research-articleACS PublicationsRequest reuse permissionsArticle Views237Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Leaving on a plane jet (2002)

This is a continuation of our research on the Universal Planar Manipulator (UPM), a device capable of manipulating multiple generic objects with a single horizontally-vibrating, rigid plate (3 DOFs). Objects are propelled by sliding frictional forces developed against the vibrating plate. A special plate vibration creates an average force field called the "jet" which is local, i.e., it is only non-zero near its center. By applying jets at different objects' locations in succession, objects can be made to displace a small amount individually, enabling full parallel manipulation. In particular, a single object can leave on a plane jet, if the jet's center is made to track and its direction made aligned with that object's motion. We provide visualization of the jet with respect to changes in its center, orientation, and focus parameters. Described also are two experiments showing the UPM as a tangible-user interface (docking a beer can to the user's hand) and as a chess player (executing moves of an endgame).
Continuous Ion Source for a Time-of-Flight Mass Spectrometer (1963)

With simple modifications improved performance of continuous ion sources in a time of flight mass spectrometer has been obtained. The system was developed for use with heated filament surface ionization sources; however, the advantages of its use with an electron bombardment source seem more significant. With an electron gun operating continuously, a factor of 300 increase in sensitivity over that of the pulsed mode of operation is attained with improved resolution and no increase in the ratio of noise to signal.
A Two-factor Authentication Mechanism Using Mobile Phones (2008)

Mobile devices are becoming more pervasive and more advanced with respect to their processing power and memory size. Relying on the personalized and trusted nature of such devices, security features can be deployed on them in order to uniquely identify a user to a service provider. In this paper, we present a strong authentication mechanism that exploits the use of mobile devices to provide a two-factor authentication method. Our approach uses a combination of one-time passwords, as the first authentication factor, and credentials stored on a mobile device, as the second factor, to offer a strong and secure authentication approach. We also present an analysis of the security and usability of this mechanism. The security protocol is analyzed against an adversary model; this evaluation proves that our method is safe against various attacks, most importantly key logging, shoulder surfing, and phishing attacks. Our usability evaluation shows that, although our technique does add a layer of indirectness that lessens usability, participants were willing to tradeoff that usability for enhanced security once they became aware of the potential threats when using an untrusted computer.
p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts. (1991)

It has been shown previously that mutant p53 can act as an immortalizing gene when cotransfected into primary rat embryo fibroblasts along with a selectable marker. To determine whether a mutation at the p53 locus is a common event in the pathways leading to spontaneous cellular immortalization, 11 clonally derived BALB/c murine embryo fibroblast lines were established by passage on a 3T3 schedule and examined for p53 alterations. By the following criteria, all 11 independently established lines contain at least one mutant allele of p53. Seven of these lines have a PAb240-reactive p53 species and exhibit an extended p53 half-life as determined by pulse-chase analysis. The p53 protein species in a subset of these lines is also capable of complex formation with the constitutive heat shock protein hsc70. p53 cytoplasmic DNAs (cDNAs) from several of these lines have been cloned by reverse transcription of cytoplasmic RNA followed by PCR amplification, and the mutations have been mapped by DNA sequence analysis. Point mutation in conserved domains of p53 appears to be a common alteration in these lines, although one established line carries a 24-bp in-frame deletion of p53. The remaining four cell lines do not express detectable p53 protein. For each line there is a different molecular event underlying the lack of p53 expression: (1) deletion of at least the first 6 exons of both p53 alleles; (2) expression of a single p53 mRNA encoding a stop codon at amino acid position 173; (3) no detectable p53 mRNA; and (4) greatly diminished expression of p53 mRNA. These findings indicate that p53 alteration commonly occurs in spontaneously immortalized BALB/c mouse embryo fibroblasts passaged on a 3T3 schedule and, therefore, may be an important event for the immortalization process.
Site-directed mutagenesis of the arginine-glycine-aspartic acid in vitronectin abolishes cell adhesion (1993)

Vitronectin (VN), a major cell adhesion protein, is found in plasma and in the extracellular matrix. At least three distinct cell surface receptors for vitronectin belonging to the integrin superfamily have been identified in normal and neoplastic cells. Many cell adhesion ligands, including vitronectin, contain an Arg-Gly-Asp (RGD) sequence mediating, in part, the ligand-receptor interaction. These ligands bind different integrins with varying specificity and affinity. The mechanism of receptor specificity remains controversial. To determine the role of the RGD sequence in receptor specificity, we amplified the cDNA for human vitronectin from a liver cDNA library and generated two separate mutants by utilizing site-directed mutagenesis resulting in aspartic acid (Asp47) to glutamic acid (Glu47) substitution and glycine (Gly46) to alanine (Ala46) substitution. The mammalian expression vector, pZEM229R, was used to transfect baby hamster kidney cells which secreted recombinant proteins into the supernatant. All recombinant proteins were isolated by heparin-agarose chromatography and tested for interaction with three known vitronectin receptors, namely, alpha IIIb beta 3 on thrombin-activated platelets, alpha v beta 3 on human umbilical vein endothelial cells and alpha v beta 5 on Panc-1 cells. Recombinant wild-type vitronectin behaved in a fashion similar to plasma-derived vitronectin. Both the RGE-VN and RAD-VN recombinant mutant proteins showed complete loss of cell adhesion activity, regardless of the receptor. These results confirm the essential and central role of the RGD sequence in vitronectin for cell adhesion. This expression system allows further structure/function analysis of vitronectin.