gebhart/patrepeval huggingface dataset:
Assisting Multimodal Travelers: Design and Prototypical Implementation of a Personal Travel Companion (2007)

Abstract—Increasing the share of multimodal journeys is be-coming more and more urgent in our society in order to guarantee a high level of mobility in the long term. While car drivers are already assisted by advanced guidance and navigation facilities, continuous on-trip assistance for multimodal travelers is still in its infancy. Especially when it comes to situations of modal change, travelers get discouraged by the increased complexity and the lack of adequate information and guidance. Thus, the goal of our research over the past three years has been to integrate existing information systems and to design and implement the prototype of a digital personal travel companion for multimodal travelers. This paper discusses typical travel situations and possible barriers for people traveling on multimodal journeys. To address these chal-lenges, functional requirements for a personal travel companion are derived from the analysis of the situations. The main sections of this paper describe our results focusing on personalized mul-timodal journey planning, mobile multimodal trip management, and smart-phone-based pedestrian orientation and guidance in complex public transport transfer buildings. Index Terms—Digital assistants, multimodal transport, nav-igation systems, pedestrian guidance, public transport, travel information systems. I.
Dynamic Demand Response Controller Based on Real-Time Retail Price for Residential Buildings (2014)

Demand response and dynamic retail pricing of electricity are key factors in a smart grid to reduce peak loads and to increase the efficiency of the power grid. Air-conditioning and heating loads in residential buildings are major contributors to total electricity consumption. In hot climates, such as Austin, Texas, the electricity cooling load of buildings results in critical peak load during the on-peak period. Demand response (DR) is valuable to reduce both electricity loads and energy costs for end users in a residential building. This paper focuses on developing a control strategy for the HVACs to respond to real-time prices for peak load reduction. A proposed dynamic demand response controller (DDRC) changes the set-point temperature to control HVAC loads depending on electricity retail price published each 15 minutes and partially shifts some of this load away from the peak. The advantages of the proposed control strategy are that DDRC has a detailed scheduling function and compares the real-time retail price of electricity with a threshold price that customers set by their preference in order to control HVAC loads considering energy cost. In addition, a detailed single family house model is developed using OpenStudio and Energyplus considering the geometry of a residential building and geographical environment. This HVAC modeling provides simulation of a house. Comfort level is, moreover, reflected into the DDRC to minimize discomfort when DDRC changes the set-point temperature. Our proposed DDRC is implemented in MATLAB/SIMULINK and connected to the EnergyPlus model via building controls virtual test bed (BCVTB). The real-time retail price is based on the real-time wholesale price in the ERCOT market in Texas. The study shows that DDRC applied in residential HVAC systems could significantly reduce peak loads and electricity bills with a modest variation in thermal comfort.
Transcriptional regulation of two genes specifically induced by glucose starvation in a hamster mutant fibroblast cell line. (1983)

This report concerns the characterization of the RNA transcripts encoded by two cDNA sequences p4A3 and p3C5, derived from a hamster temperature-sensitive mutant cell line K12. Using the two cDNA sequences as hybridization probes, we show that they occur as single copy genes in the hamster genome and encode for RNA transcripts which are highly inducible in K12 cells at 40.5 degrees C. After incubation at 40.5 degrees C for 16 h, there is a 10-fold increase in the p4A3 and p3C5 mRNA levels, reaching a final concentration of about 1% of the cytoplasmic polyadenylated RNA. We demonstrate that the kinetics of transcription of p4A3 and p3C5 directly parallel the accumulation of the mRNA levels at 40.5 degrees C. Thus, our data indicate that the expression of these two genes are primarily regulated at the transcriptional level. In addition, there is a 3- to 4-fold increase in the p4A3 and p3C5 mRNA levels when the cells are specifically starved of glucose. This implies that the expression of these two genes are stringently regulated by the availability of glucose in the culture medium. The relationship between the cDNA clones and two glucose-regulated proteins which are overproduced in K12 cells at 40.5 degrees C is discussed.
Carboplatin and etoposide in advanced colorectal carcinoma. A phase II study (1993)

Response rate and toxic effects observed during this study warrant additional studies comparing this regimen with 5-FU-based regimens in advanced colorectal carcinoma.
Hepatitis induced by drugs used as alcohol aversion therapy. (1983)

We report here on the hepatic lesions produced in 17 alcoholic patients who had received Cyanamide or Disulfiram as aversion therapy. The characteristic lesion consists of cytoplasmic inclusions, similar to Lafora bodies. They are found predominantly in periportal hepatocytes, including those lining the cholangioles. They appear to be persistent but are lost after death of the inclusion-bearing liver-cell when both the inclusion body and the dead hepatocyte are removed by macrophages. As well as the inclusion bodies, portal or periportal inflammation and necrosis of isolated liver-cells are seen. The inflammatory infiltrate is usually denser in the periportal areas and is associated with liver-cell destruction. The inflammation is usually followed by portal fibrosis which can be severe if treatment is prolonged. In one case, in which two biopsies were performed, cirrhosis developed while that patient was on Cyanamide.
Expression and function of KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes (2003)

Using monoclonal antibodies (mAbs) specific for different natural killer (NK) receptors, we studied the lymphocyte population from 18 patients with NK-type lymphoproliferative disease of granular lymphocytes (LDGL). The analysis of both resting and cultured NK cell populations demonstrated that these patients are frequently characterized by NK cells displaying a homogeneous staining with given anti-killer Ig-like receptor (anti-KIR) mAb (11 of 18 patients). In most patients NK cells were characterized by the CD94/NKG2A+ phenotype, whereas only a minor fraction of the cases expressed CD94/NKG2C. In 7 of these patients we could also assess the function of the various NK receptors. Remarkably those KIR molecules that, in each patient, homogeneously marked the NK cell expansion were found to display an activating function as determined by cross-linking with specific anti-KIR mAb. The KIR genotype analysis performed in 13 of 18 cases revealed that in NK-type LDGL certain activating KIRs, as well as certain infrequent KIR genotypes, were detected with higher frequencies as compared to previously analyzed healthy donors. Moreover, most KIR genotypes included multiple genes coding for activating KIRs. The analysis of non-HLA-specific triggering receptors indicated that the natural cytotoxicity receptors (NKp46, NKp30) were expressed at significantly low levels in freshly drawn NK cells from most patients analyzed. However, in most instances the expression of NKp46 and NKp30 could be up-regulated on culture in interleukin 2. Our data indicate that in NK-LDGL the expanded subset is frequently characterized by the expression of a given activating KIR, suggesting a direct role for these molecules in the pathogenetic mechanisms of this disorder.
Fundamental consolidation mechanisms during selective beam melting of powders (2013)

During powder based additive manufacturing processes, a component is realized layer upon layer by the selective melting of powder layers with a laser or an electron beam. The density of the consolidated material, the minimal spatial resolution as well as the surface roughness of the resulting components are complex functions of the material and process parameters. So far, the interplay between these parameters is only partially understood.
Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement (2015)

Ischemic brain tissue-targeted and selective inhibition of alternative complement pathway provide self-limiting inhibition of complement activation and reduces acute injury while maintaining complement-dependent recovery mechanisms into the subacute phase after stroke.
Implicit skinning (2013)

Geometric skinning techniques, such as smooth blending or dual-quaternions, are very popular in the industry for their high performances, but fail to mimic realistic deformations. Other methods make use of physical simulation or control volume to better capture the skin behavior, yet they cannot deliver real-time feedback. In this paper, we present the first purely geometric method handling skin contact effects and muscular bulges in real-time. The insight is to exploit the advanced composition mechanism of volumetric, implicit representations for correcting the results of geometric skinning techniques. The mesh is first approximated by a set of implicit surfaces. At each animation step, these surfaces are combined in real-time and used to adjust the position of mesh vertices, starting from their smooth skinning position. This deformation step is done without any loss of detail and seamlessly handles contacts between skin parts. As it acts as a post-process, our method fits well into the standard animation pipeline. Moreover, it requires no intensive computation step such as collision detection, and therefore provides real-time performances.
DIRECTOR DEL CENTRO DE INVESTIGACION Y SERVICIOS MUSEOLOGICOS (1980)

LOS MUSEOS SON LA UNIVERSIDAD ABIERTA PORQUE SON EL RECINTO DONDE PUEDEN ENTRAR; INDISCRIMINADAMENTE; PERSONAS DE CUALQUIER ESTRATO SOCIAL; DIJO EL LICENCIADO RODOLFO RIVERA GONZALEZ; DIRECTOR DEL CENTRO DE INVESTIGACION Y SERVICIOS MUSEOLOGICOS; QUIEN ADEMAS CONSIDERO QUE LOS MUSEOS SON UN MEDIO DE COMUNICACION PORQUE ENSENAN EN TODOS LOS NIVELES.
MMP‐Mediated Events in Diabetes (1999)

Both Type I and Type II diabetes mellitus (DM) have been associated with unusually aggressive periodontitis. Accordingly, rat models of both types of DM were used to study (i) mechanisms mediating this systemic/local interaction and (ii) new pharmacologic approaches involving a series of chemically modified tetracyclines (CMTs) that have lost their antimicrobial but retained their host-modulating (e.g., MMP-inhibitory) properties. In vitro experiments on tissues from Type I DM rats demonstrated that several of these CMTs were better matrix metalloproteinase (MMP) inhibitors than was antibacterial doxycycline (doxy), except for CMT-5, which, unlike the other MMP inhibitors, was found not to react with zinc. Data from in vivo studies on the same rat model generally supported the relative efficacy of these compounds: the CMTs and doxy were found to inhibit MMP activity, enzyme expression, and alveolar bone loss. To examine other long-term complications such as nephropathy and retinopathy, a Type II (ZDF) model of DM was studied. Treatment of these DM rats with CMT-8 produced a 37% (p < 0.05), 93% (p < 0.001), and 50% (p < 0.01) reduction in the incidence of cataract development, proteinuria, and tooth loss, respectively; whereas the doxy-treated ZDF rats showed little or no effect on these parameters. CMT treatment decreased mortality of the Type II ZDF diabetic animals, clearly indicating that CMTs, but not commercially available antibiotic tetracyclines (TCs), may have therapeutic applications for the long-term management of diabetes.
Characterization of wafer geometry and overlay error on silicon wafers with nonuniform stress (2013)

Process-induced overlay errors are a growing problem in meeting the ever-tightening overlay requirements for integrated circuit production. Although uniform process-induced stress is easily corrected, nonuniform stress across the wafer is much more problematic, often resulting in noncorrectable overlay errors. Measurements of the wafer geometry of free, unchucked wafers give a powerful method for characterization of such nonuniform stress-induced wafer distortions. Wafer geometry data can be related to in-plane distortion of the wafer pulled flat by an exposure tool vacuum chuck, which in turn relates to overlay error. This paper will explore the relationship between wafer geometry and overlay error by the use of silicon test wafers with deliberate stress variations, i.e., engineered stress monitor (ESM) wafers. A process will be described that allows the creation of ESM wafers with nonuniform stress and includes many thousands of overlay targets for a detailed characterization of each wafer. Because the spatial character of the stress variation is easily changed, ESM wafers constitute a versatile platform for exploring nonuniform stress. We have fabricated ESM wafers of several different types, e.g., wafers where the center area has much higher stress than the outside area. Wafer geometry is measured with an optical metrology tool. After fabrication of the ESM wafers including alignment marks and first level overlay targets etched into the wafer, we expose a second level resist pattern designed to overlay with the etched targets. After resist patterning, relative overlay error is measured using standard optical methods. An innovative metric from the wafer geometry measurements is able to predict the process-induced overlay error. We conclude that appropriate wafer geometry measurements of in-process wafers have strong potential to characterize and reduce process-induced overlay errors.
Characterization of the B lymphocyte response to pokeweed mitogen. (1983)

Human B lymphocytes activated by pokeweed mitogen (PWM) undergo a proliferative response, differentiate into immunoglobulin producing cells (IPC), and release immunoglobulin into the supernatant fluid of the lymphocyte cultures. Since the number of IPC and amount of immunoglobulin produced may be determined in part by the proportions of T and non-T lymphocytes in the culture, studies were undertaken on the kinetics of the PWM induced response in cultures containing 1 : 1 proportions of T and non-T cells from nine healthy adults. Blood samples were obtained from each individual on two occasions and the results compared. The proliferative response, number of cells containing intracytoplasmic immunoglobulin (ICIg) and the concentration of supernatant immunoglobulin (SIg) were serially determined. The mean peak proliferative response and the mean peak number of ICIg positive cells were observed on the fifth day of culture. The mean peak concentration of SIg was noted on the ninth to eleventh day of culture. The results of the initial specimens were not significantly different from those of the repeat samples. It is concluded that a 1 : 1 mixture of T and non-T cells respond reproducibly to PWM and that the level of response varies with the length of incubation of the cultures. It is believed these assays might be helpful in the investigation of various lymphoproliferative and immunodeficiency disorders.
Role of Phosphodiesterase 3 in NO/cGMP-Mediated Antiinflammatory Effects in Vascular Smooth Muscle Cells (2003)

Atherosclerosis involves cellular immune responses and altered vascular smooth muscle cell (VSMC) function. Nitric oxide (NO)/cGMP is uniquely capable of inhibiting key processes in atherosclerosis. In this study, we determined the effects of NO/cGMP and their molecular mechanisms in the regulation of NF-kappaB-dependent gene expression in VSMCs. We found that cGMP-elevating agents such as the NO donor S-nitroso-N-acetylpenicillamine (SNAP) and C-type natriuretic peptide (CNP), reduced TNF-alpha-induced NF-kappaB-dependent reporter gene expression in rat aortic VSMCs in a cGMP-dependent manner. The effects of SNAP and CNP on NF-kappaB are mediated by cAMP-dependent protein kinase (PKA) but not cGMP-dependent protein kinase (PKG) based on the findings that the selective PKA inhibitor, PKI, abolished the effects of SNAP and CNP on NF-kappaB, whereas the PKG inhibitor Rp-8-Br-PET-cGMP had no effect. Inhibition of cGMP-inhibited cAMP-hydrolyzing phosphodiesterase 3 (PDE3) blocked SNAP- and CNP-elicited effects on NF-kappaB-dependent transcription. Furthermore, cGMP analogues such as 8-pCPT-cGMP, which selectively activates PKG but does not inhibit PDE3, had no effect on NF-kappaB-mediated transcription. Activation of PKA by SNAP or cAMP-elevating agents not only inhibited TNF-alpha-induced NF-kappaB-dependent reporter gene expression but also reduced endogenous NF-kappaB-dependent adhesion molecule and chemokine expression. These results suggest that SNAP and CNP exert inhibitory effects on NF-kappaB-dependent transcription by activation of PKA via cGMP-dependent inhibition of PDE3 activity. Therefore, PDE3 is a novel mediator of inflammation in VSMCs.
An Integrated Study of Fibrinogen during Blood Coagulation (1999)

The rate of conversion of fibrinogen (Fg) to the insoluble product fibrin (Fn) is a key factor in hemostasis. We have developed methods to quantitate fibrinopeptides (FPs) and soluble and insoluble Fg/Fn products during the tissue factor induced clotting of whole blood. Significant FPA generation (>50%) occurs prior to visible clotting (4 +/- 0.2 min) coincident with factor XIII activation. At this time Fg is mostly in solution along with high molecular weight cross-linked products. Cross-linking of gamma-chains is virtually complete (5 min) prior to the release of FPB, a process that does not occur until after clot formation. FPB is detected still attached to the beta-chain throughout the time course demonstrating release of only low levels of FPB from the clot. After release of FPB a carboxypeptidase-B-like enzyme removes the carboxyl-terminal arginine resulting exclusively in des-Arg FPB by the 20-min time point. This process is inhibited by epsilon-aminocaproic acid. These results demonstrate that transglutaminase and carboxypeptidase enzymes are activated simultaneously with Fn formation. The initial clot is a composite of Fn I and Fg already displaying gamma-gamma cross-linking prior to the formation of Fn II with Bbeta-chain remaining mostly intact followed by the selective degradation of FPB to des-Arg FPB.
Topotecan, a new active drug in the second-line treatment of small-cell lung cancer: a phase II study in patients with refractory and sensitive disease. The European Organization for Research and Treatment of Cancer Early Clinical Studies Group and New Drug Development Office, and the Lung Cancer Cooperative Group. (1997)

Topotecan has significant activity in SCLC, particularly in patients sensitive to prior chemotherapy, with predictable and manageable toxicity. The incorporation of topotecan in combination chemotherapy regimens for future treatment of SCLC is warranted.
Module for simultaneous C+L-band dispersion compensation and Raman amplification (2002)

A single DCF module capable of compensating the dispersion in the full C+L-band of a prototype Raman optimized NZDF has been demonstrated. The residual dispersion from 1530 to 1610 nm was controlled within /spl plusmn/0.07 ps/(nm/spl middot/km). The dispersion margin for 40 Gbit/s transmission is around /spl plusmn/60 ps/nm/sup 3/. Therefore, It will be possible to transmit DWDM 40 Gbit channels in the full C+L-band for around 850 km without any per channel dispersion trimming. The module is also an ideal lumped Raman amplifier. Using a total pump power of 1042 mW an average net gain of 10.1 dB was demonstrated from 1530 to 1607 nm. Noise figure was less than 6 dB in whole wavelength range, and OSNR from double Rayleigh scattering was better than 40 dB. The module will be ideal for use together with the Raman optimized transmission fiber in all Raman systems. Such a system will compared to a conventional system with EDFA's not require any band splitting and therefore support more channel with less loss and lower cost.
A new join algorithm (1994)

This paper introduces a new efficient join algorithm to increase the speed of the join relational operation. Using a divide and conquer strategy, stack oriented filter technique in the new join algorithm filters unwanted tuples as early as possible while none of the currently existing join algorithms takes advantage of any filtering concept. Other join algorithms may carry the unnecessary tuples up to the last moment of join attribute comparisons.Four join algorithms are described and discussed in this paper: the nested-loop join algorithm, the sort-merge join algorithm, the hash join algorithm, and the new join algorithm.
Antioxidant Activity of a Combinatorial Library of Emulsifier−Antioxidant Bioconjugates (2008)

A combinatorial chemistry approach was employed for the design and systematic synthesis of antioxidant-emulsifier bioconjugates to improve antioxidant activity in the interface between oil and water. A combinatorial library of 12 bioconjugates was synthesized from the phenolic antioxidants Trolox (a water-soluble alpha-tocopherol analogue), dihydroferulic acid, dihydrocaffeic acid, and gallic acid in combination with serine ethyl ester, serine lauryl ester, and lauroyl serine by esterification of the serine side chain or amidation, respectively. The bioconjugates were characterized by NMR and mass spectrometry, and each was tested for antioxidant activity by measuring the radical scavenging rate of 2,2-diphenyl-1-picrylhydrazyl (DPPH (*)) in methanol, the radical scavenging rate of DPPH (*) in a heterogeneous solvent system, the rate of oxygen consumption in an oil-in-water emulsion with metmyoglobin initiated oxidation, and the lag phase for diene formation in unilamellar liposomes with free radical initiation in the aqueous phase; each case was compared to the antioxidant activity of the parent antioxidant. In general, the conjugates with longer chain derivatives exhibited improved antioxidative activity in heterogeneous systems, whereas no improvement was observed in homogeneous solution. The rate of oxygen consumption in oil-in-water emulsion was found to decrease with increasing octanol/water partition coefficient, which is suggested to correspond to a saturation of the water/oil interface with antioxidant bioconjugate to approach maximal protection.
MICROSTRUCTURE DEVICES FOR APPLICATIONS IN THERMAL AND CHEMICAL PROCESS ENGINEERING (2001)

Abstract Metallic microstructure devices have been manufactured and tested for applications in technical applications in thermal and chemical process engineering and in the laboratory. Manufacturing has been performed by micromachining of metal foils and diffusion bonding of a laminated foil stack, followed by welding of the microstructured core into a housing. Crossflow and counterflow micro heat exchangers with microchannel or microcolumn structures have been developed for throughputs up to 7 t water/h with a heat transmission power up to 200 kW. Overall heat transfer coefficients up to 54,000 W/m2 K have been determined with water as test fluid. Electrically driven microstructured heaters have been developed for fast and precise heating of sensitive liquids or gases. The heater has been used as an evaporator as well. Static micromixers have been developed for fast and complete mixing of reactands. They can be utilized with parallel reactions, for example, to decrease the yield of undesired by-products. For heterogeneously catalyzed reactions, several methods have been developed to coat fluid passages of already manufactured microstructure devices with thin catalytic layers.