gebhart/patrepeval huggingface dataset:
Prevention of Bacterial Biofilm Formation on Soft Contact Lenses Using Natural Compounds (2017)

This study demonstrated that isolates from infected eye and CL-cases showed weak to moderate biofilm formation. Calendula officinalis and Buddleja salviifolia extracts showed excellent effect on inhibition and removal of biofilm, these extracts could be added into CL-care solutions which could markedly reduce eye-infections during CL-wear.
Loss of Apolipoprotein E Receptor LR11 in Alzheimer Disease (2004)

There is loss of the microarray-derived candidate, LR11, in neurons of AD brains. This study shows that microarray analysis of widely available lymphoblasts derived from patients with AD holds promise as a primary screen for candidate genes associated with AD.
Artificial compound eye zoom camera (2008)

We demonstrate a highly compact image capturing system with variable field of view but without any mechanically moving parts. The camera combines an ultra-thin artificial apposition compound eye with one variable focal length liquid lens. The change of optical power of the liquid lens when applying a voltage results in a change of the magnification of the microlens array imaging system. However, its effect on focusing of the individual microlenses can be neglected due to their small focal length.
Optical Properties of Surface-Enhanced Raman-Active Capture Matrices (2006)

Silver and gold colloidal particles can be immobilized on amine-derivatized magnetic microparticles. Once immobilized, the colloidal particles can be reacted with thiols to form a self-assembled monolayer (SAM). Earlier it was shown that the resultant derivatized magnetic microparticles, i.e., capture matrices, are surface-enhanced Raman (SERS) active and that they can be used to extract trace amounts of analyte from an aqueous sample. In this investigation, the optical properties of the capture matrices are examined. Imaging of these magnetic microparticles shows that the immobilized silver/gold colloidal particles exhibit blinking behavior. An increase in the SERS signals due to the SAM and the continuum is observed with constant laser illumination of these magnetic microparticles. Such an increase can be used to improve sensitivity. This increase in signal is attributed to the electromagnetic enhancement mechanism (EEM).
Molecular cloning and sequence analysis of cDNA encoding human prostatic acid phosphatase (1988)

lambda gt11 clones encoding human prostatic acid phosphatase (PAP) (EC 3.1.3.2) were isolated from human prostatic cDNA libraries by immunoscreening with polyclonal antisera. Sequence data obtained from several overlapping clones indicated that the composite cDNAs contained the complete coding region for PAP, which encodes a 354-residue protein with a calculated molecular mass of 41,126 Da. In the 5'-end, the cDNA codes for a signal peptide of 32 amino acids. Direct protein sequencing of the amino-terminus of the mature protein and its proteolytic fragments confirmed the identity of the predicted protein sequence. PAP has no apparent sequence homology to other known proteins. However, both the cDNA clones coding for human placental alkaline phosphatase and PAP have an alu-type repetitive sequence about 900 nucleotides downstream from the coding region in the 3'-untranslated region. Two of our cDNA clones differed from others at the 5'-ends. RNA blot analysis indicated mRNA of 3.3 kb. We are continuing to study whether acid phosphatases form a gene family as do alkaline phosphatases.
Shouldice Inguinal Hernia Repair in the Male Adult (1995)

Shouldice hernia repair provides the patient with the best chances of nonrecurrence regardless of the anatomical type of hernia. The Shouldice hernia repair should be the gold standard for inguinal hernia repair in men and serves as the basis for comparison with all other techniques, be they prosthetic or laparoscopic.
Efficiency droop in light‐emitting diodes: Challenges and countermeasures (2013)

Abstract Efficiency droop, i.e. the loss of efficiency at high operating current, afflicts nitride‐based light‐emitting diodes (LEDs). The droop phenomenon is currently the subject of intense research, as it retards the advancement of solid‐state lighting which is just starting to supplant fluorescent as well as incandescent lighting. Although the technical community does not yet have consented to a single cause of droop, this article provides a summary of the present state of droop research, reviews currently discussed droop mechanisms, and presents a recently developed theoretical model for the efficiency droop. In the theoretical model, carrier leakage out of the active region caused by the asymmetry of the pn junction, specifically the disparity between electron and hole concentrations and mobilities, is discussed in detail. The model is in agreement with the droop's key behaviors not only for GaInN LEDs but also for AlGaInP LEDs.
Streaming Pattern Discovery in Multiple Time-Series (2018)

In this paper, we introduce SPIRIT (Streaming Pattern dIscoveRy in multIple Timeseries). Given n numerical data streams, all of whose values we observe at each time tick t, SPIRIT can incrementally find correlations and hidden variables, which summarise the key trends in the entire stream collection. It can do this quickly, with no buffering of stream values and without comparing pairs of streams. Moreover, it is any-time, single pass, and it dynamically detects changes. The discovered trends can also be used to immediately spot potential anomalies, to do efficient forecasting and, more generally, to dramatically simplify further data processing. Our experimental evaluation and case studies show that SPIRIT can incrementally capture correlations and discover trends, efficiently and effectively.
Potent Inhibitors of Proteasome (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotent Inhibitors of ProteasomeMohamed Iqbal, Sankar Chatterjee, James C. Kauer, Manoj Das, Patricia Messina, Bethany Freed, William Biazzo, and Robert SimanCite this: J. Med. Chem. 1995, 38, 13, 2276–2277Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/jm00013a002https://doi.org/10.1021/jm00013a002research-articleACS PublicationsRequest reuse permissionsArticle Views378Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Smuggling Armageddon: the nuclear black market in the former Soviet Union and Europe (1999)

Smuggling Armageddon looks at one of the most important and troubling international concerns of the 1990s and beyond: the illegal trade in nuclear materials that has erupted in the Newly Independent States (NIS) and Europe since the collapse of the former Soviet Union. Lee raises the central yet seldom-asked question of whether such traffic poses a threat to international security and stability. He unveils a grim picture that shows a Russia characterized by a variety of criminal proliferation channels; a Russia where smuggling operations are becoming progressively more sophisticated; and a Russia whose nuclear stockpiles already may have suffered serious leakages of weapons -- usable materials. Lee concludes his groundbreaking work by assessing the implications of study findings for U.S. policy and by offering insights on the future of the NIS smuggling industry.
A conceptual study of a voice conversation facility in intelligent nw voice mail (2005)

Intelligent networks, which offer enhanced telecommunication services and operations through distributed network resources, are discussed in parallel with ISDN implementation. A user-friendly human-machine interface is one of the most important elements of an intelligent networks. This paper proposes a voice conversation facility with the following configuration and functions to be used in an intelligent network. The human-machine interface is to be implemented as an intelligent peripheral function which is an intelligent network node commonly used for many services. This function is to be conceptualized as an automated network operator, which can operate many services. An instantaneous service activation, automated service operations and easy input/output by interactive voice interface are essential for this concept. In addition, a system design example of an intelligent voice mail system is discussed. The system is based on a conversational model which is determined from 600 operator conversations and applying the voice recognition techniques available in the near future. Using speaker-independent word-spotting techniques which recognize up to 100 words from a continuously spoken sentence, the system will be able to converse naturally with users for selecting voice mail services and functions.
Sensing issues related to the clinical use of implantable loop recorders (2003)

Undoubtedly this device is the current gold standard for the diagnosis of unexplained syncope. In the population we studied though, the device faced undersensing problems. Consequently, the device should be equipped with more advanced software for QRS morphology recognition, to improve the diagnostic accuracy of the recorder.
Precise hepatectomy following important liver vessels for hepatobiliary tumors (2015)

Objective
To investigate the application value of precise hepatectomy following important liver vessels for hepatobiliary tumors.


Methods
Clinical data of 26 patients with hepatobiliary tumors in the First Affiliated Hospital of Zhengzhou University from January 2012 to January 2013 were analyzed retrospectively. There were 14 males and 12 females with the age ranging from 20 to 66 years old and a median of 56 years old. The informed consents of all patients were obtained and local ethical committee approval had been received. The important vessels closely adjacenting to tumors were selected as the guide line for dissection according to the preoperative imaging examinations and intraoperative exploration results and the liver resecting surface was predicted. The anatomic relations between the tumor and the important liver vessels such as portal branch, hepatic vein, inferior vena cava were defined by intraoperative ultrasound. Precise hepatectomy were performed with surgical instruments such as cavitron ultrasonic surgical aspirator, bipolar coagulator.


Results
The operations of 26 patients were performed successfully and the tumors were resected completely, including left hemihepatectomy + caudate lobectomy (n=7), right hemihepatectomy (n=6), mesohepatectomy (n=4), extended right hemihepatectomy (n=3), segment Ⅳb, V hepatectomy (n=2), hepatic right anterior lobectomy (n=2), left hemihepatectomy + caudate lobectomy + pancreaticoduodenectomy (n=1), caudate lobectomy + artificial vessel replacement of retrohepatic inferior vena cava (n=1). The average operative time was (5.3±0.4) h, the intraoperative blood loss was (580±59) ml and the length of hospital stay was (19±3) d. No severe complications such as massive haemorrhage, liver failure were observed after operation. Abdominal infection was observed in 2 cases and biliary leakage in 1 case after operation and all were cured by anti-infection and drainage treatments.


Conclusion
Precise hepatectomy following the important liver vessels is a safe and effective surgical procedure for hepatobiliary tumors.


Key words: 
Liver neoplasms; Bile ducts, intrahepatic; Hepatectomy
Unexpected Enzymatic Fucosylation of the Hindered Tertiary Alcohol of 3-<i>C</i>-Methyl-<i>N</i>-Acetyllactosamine Produces a Novel Analogue of the LeX-Trisaccharide (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTUnexpected Enzymatic Fucosylation of the Hindered Tertiary Alcohol of 3-C-Methyl-N-Acetyllactosamine Produces a Novel Analogue of the LeX-TrisaccharideXiangping Qian, Ole Hindsgaul, Hong Li, and Monica M. PalcicView Author Information Department of Chemistry, University of Alberta Edmonton, Alberta T6G 2G2, Canada Cite this: J. Am. Chem. Soc. 1998, 120, 9, 2184–2185Publication Date (Web):February 20, 1998Publication History Received25 September 1997Published online20 February 1998Published inissue 1 March 1998https://pubs.acs.org/doi/10.1021/ja973361whttps://doi.org/10.1021/ja973361wrapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views200Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Alkyls,Carbohydrates,Oligosaccharides,Peptides and proteins Get e-Alerts
Intramolecular epitope spreading among anti-caspase-8 autoantibodies in patients with silicosis, systemic sclerosis and systemic lupus erythematosus, as well as in healthy individuals (2002)

Dysregulation of apoptosis through the Fas-Fas ligand pathway is relevant in autoimmune disease onset. We recently reported elevated serum levels of sFas in patients with silicosis, systemic sclerosis (SSC) and systemic lupus erythematosus (SLE), and proposed a block of apoptosis in the pathogenesis. The disturbance of apoptosis in lymphocytes including autoreactive clones could induce autoantibody production. Since autoantibodies directed against unknown antigens are present in the sera of these patients, the sera samples were examined for the presence of autoantibodies directed to caspase-8. Using Western blotting, autoantibodies against caspase-8 were detected in healthy individuals and in over 60% of patients. Using epitope mapping employing 12 amino acid polypeptides with SPOTs system, a minimum of 4 epitopes and a maximum of 13 were found, which implied that epitope spreading was in progress. It is noteworthy that two important catalytic cystein residues were included within the epitopes; firstly the active site cystein Cys287, and secondly Cys360 located in the unique pentapeptide motif QACQG. Using recombinant human caspase-8 linked protein chip array, autoantibodies were identified and molecular weight determined. The antibodies were mainly IgG; 80% were subclass IgG1(lambda); 20% were IgG4(kappa). Despite the ratio of human light chain kappa:lambda = 2:1, the predominance of IgG1(lambda) is noticeable. Anti-caspase-8 autoantibodies are detectable in healthy individuals and in patients suffering silicosis, SSc or SLE. A few epitopes were detected in healthy individuals compared to those suffering autoimmune diseases, indicating the intramolecular epitope spreading. Relationship of autoantibodies and the clinical background of the patients requires clarification.
Multistage Cutting Stock Problems of Two and More Dimensions (1965)

In earlier papers [Opns. Res. 9, 849–859 (1961), and 11, 863–888 (1963)] the one-dimensional cutting stock problem was discussed as a linear programming problem. There it was shown how the difficulty of the enormous number of columns occurring in the linear programming formulation could be overcome by solving a knapsack problem at every pivot step. In this paper higher dimensional cutting stock problems are discussed as linear programming problems. The corresponding difficulty of the number of columns cannot in general be overcome for there is no efficient method for solving the generalized knapsack problem of the higher dimensional problem. However a wide class of cutting stock problems of industry have restrictions that permit their generalized knapsack problem to be efficiently solved. All of the cutting stock problems that yield to this treatment are ones in which the cutting is done in stages. In treating these practical cutting problems, one often encounters additional conditions that affect the solution. An example of this occurs in the cutting of corrugated boxes, which involves an auxiliary sequencing problem. This problem is discussed in some detail, and a solution described for the sequencing problem under given simplifying assumptions.
Behavior Assessment Model for Trace Organics in Soil: I. Model Description (1983)

Abstract A mathematical model is introduced for describing transport and loss of soil‐applied organic chemicals. The model assumes linear, equilibrium partitioning between vapor, liquid, and adsorbed chemical phases, net first order degradation, and chemical movement to the atmosphere by volatilization loss through a stagnant air boundary layer at the soil surface. From these assumptions and the assumption of steady state upward or downward water flow, an analytic solution is derived for chemical concentration and volatilization flux. This model, which is intended to classify and screen organic chemicals for their relative susceptibility to different loss pathways (volatilization, leaching, degradation) in the soil and air, requires knowledge of the organic carbon partition coefficient ( K oc ), Henry's constant ( K H ), and net, first‐order degradation rate coefficient or chemical half‐life to use on a given chemical. Illustration of the outputs available with the model is shown for two pesticides, lindane (γ‐1,2,3,4,5,6‐hexachlorocyclohexane) and 2,4‐D [(2,4‐dichlorophenoxy)acetic acid], which have widely differing chemical properties. Lindane, with a large K oc , large K H , and small degradation rate coefficient, is shown to be relatively immobile, persistent, and susceptible to volatilization. 2,4‐D, with a small K oc , small K H , and large degradation rate coefficient, is mobile and degrades rapidly, but is only slightly susceptible to losses by volatilization.
Neuropathological investigation of dementia: a guide for neurologists (2005)

Dementia is among the most common and disabling of diseases and places a huge burden on carers and families as well as on social and medical services. Its prevalence rises from about 1.4% of adults aged between 65–70 years to 23.6% of those over 85. The number of patients with dementia is predicted to increase steeply as the proportion of people surviving well in to old age continues to rise. The annual economic cost is estimated at £7 billion per annum in the UK and over $100 billion in the USA. Accurate diagnosis of most diseases that cause dementia depends on post-mortem neuropathological examination. In this review, I shall cover some of the practical issues involved in the post-mortem investigation of dementia and describe the principal abnormalities in the more common diseases that are responsible. This is not an exhaustive review of the neuropathology of dementia, which is well covered in many large reference books and is beyond the scope of the present text. In most published series, the accuracy of clinical diagnosis of the different diseases that cause dementia is of the order of 70–80%. Establishing a precise diagnosis by post-mortem neuropathological examination will not, of course, benefit the individual patient but matters nonetheless, for several reasons:
Mutation of Three Critical Amino Acids of the N-Terminal Domain of IGF-Binding Protein-3 Essential for High Affinity IGF Binding (2001)

The N-terminal domain is conserved in all members of the IGF-binding protein superfamily. Most recently, studies have demonstrated the importance of an IGF-binding protein N-terminal hydrophobic pocket for IGF binding. To examine more critically the amino acids important for IGF binding within the full-length IGF-binding protein-3 protein while minimizing changes in the tertiary structure, we targeted residues I56, L80, and L81 within the proposed hydrophobic pocket for mutation. With a single change at these sites to the nonconserved glycine there was a notable decrease in binding. A greater reduction was seen when both L80 and L81 were substituted with glycine, and complete loss of affinity for IGF-I and IGF-II occurred when all three targeted amino acids were changed to glycine. Furthermore, the ability of the IGF-binding protein-3 mutants to inhibit IGF-I-stimulated phosphorylation of its receptor was a reflection of their affinity for IGF, with the lowest affinity mutants having the least inhibitory effect.
Chemical studies of marine bacteria: developing a new resource (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical studies of marine bacteria: developing a new resourceWilliam. FenicalCite this: Chem. Rev. 1993, 93, 5, 1673–1683Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://pubs.acs.org/doi/10.1021/cr00021a001https://doi.org/10.1021/cr00021a001research-articleACS PublicationsRequest reuse permissionsArticle Views3002Altmetric-Citations340LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts