gebhart/patrepeval huggingface dataset:
DO MOBILE PHONES DREAM OF ELECTRIC ORCHESTRAS (2009)

MoPhO is the newly established Mobile Phone Orchestra of CCRMA.It is the first repertoire-and ensemblebased mobile phone performance group of its kind.We describe the motivation and making of such an ensemble and the repertoire of MoPhO's first concert, performed in January 2008.The ensemble demonstrates that mobile phones orchestras are interesting technological and artistic platforms for electronic music composition and performance.Piece # of phones # of performers Software Input types Conducted?Drone In/Drone Out 8 or more 8 or more (1 each) C++ and python Accelerometer & keys yes The Saw 8 8 (1 each) C++ and python Accelerometer & keys yes Circular Transformations 8 8 (1 each) C++ and python Accelerometer & keys yes TamaG 5 5 (1 each) C++ and python Accelerometer & keys yes The phones and the fury 11 1-2 C++ and python Accelerometer & keys no phoning it in 12 or more 12 or more (1 each) built-in mp3 player keys no Chatter 12 or more 12 or more (1 each) C++ and python Accelerometer & keys yes MoPhive Quintet 5 5 (1 each) built-in recorder mic & keys no
Effect of Polymyxin B Nonapeptide on Daptomycin Permeability and Cell Surface Properties in Pseudomonas aeruginosa, Escherichia coli, and Pasteurella multocida. (1995)

The present study was carried out to determine if sensitization of Gram-negative bacteria to the polyanionic antibiotic daptomycin by cationic molecules can be explained on the basis of decreased cell surface charge in order to better understand intrinsic resistance. Turbidimetric assessments of batch cultural growth kinetics revealed the outer membrane permeabilizer polymyxin B nonapeptide sensitized Pseudomonas aeruginosa and Escherichia coli to the hydrophobic probe novobiocin, whereas little or no sensitization was observed for two surface hydrophobicity variants of Pasteurella multocida. Polymyxin B nonapeptide and daptomycin synergistically inhibited growth of P. aeruginosa only. A hydrocarbon adherence assay revealed permeabilizing concentrations of polymyxin B nonapeptide increased cell surface hydrophobicity of P. aeruginosa and the hydrophobic P. multocida variant, while E. coli and the hydrophilic P. multocida variant remained unaffected. Measurement of cellular electrophoretic mobility showed polymyxin B nonapeptide permeabilization of P. aeruginosa to daptomycin occurred concomitantly with a significant decrease in cell surface charge, while no such sensitization occurred in organisms which failed to undergo polymyxin B nonapeptide-induced surface charge decreases. These data suggest that sensitization of Gram-negative bacteria to polyanionic lipopeptides by growth in the presence of polycationic outer membrane permeabilizers such as polymyxin B nonapeptide is dependent on diminution of overall cell surface charge and polarity, thereby allowing outer cell envelope permeation.
Method for Production of Polymer and Carbon Nanofibers from Water-Soluble Polymers (2012)

Nanometer scale carbon fibers (carbon nanofibers) are of great interest to scientists and engineers in fields such as materials science, composite production, and energy storage due to their unique chemical, physical, and mechanical properties. Precursors currently used for production of carbon nanofibers are primarily from nonrenewable resources. Lignin is a renewable natural polymer existing in all high-level plants that is a byproduct of the papermaking process and a potential feedstock for carbon nanofiber production. The work presented here demonstrates a process involving the rapid freezing of an aqueous lignin solution, followed by sublimation of the resultant ice, to form a uniform network comprised of individual interconnected lignin nanofibers. Carbonization of the lignin nanofibers yields a similarly structured carbon nanofiber network. The methodology is not specific to lignin; nanofibers of other water-soluble polymers have been successfully produced. This nanoscale fibrous morphology has not been observed in traditional cryogel processes, due to the relatively slower freezing rates employed compared to those achieved in this study.
Paclitaxel/carboplatin for the initial treatment of advanced ovarian cancer. (1999)

In 1996, the combination of cisplatin 75 mg/m2 plus 24-hour infusion of 135 mg/m2 paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) was proved to prolong survival in comparison with cyclophosphamide/cisplatin in women with advanced ovarian cancer. As a result, the paclitaxel/cisplatin combination was recommended to serve as the new standard of care. One year later, a European-Canadian group confirmed the efficacy of paclitaxel/cisplatin in a study in which the infusion period of paclitaxel was reduced from 24 to 3 hours and the dose of paclitaxel escalated to 175 mg/m2. These changes resulted in a lower incidence of myelosuppression but a higher rate of neurotoxicity. Replacing cisplatin with carboplatin, a platinum analogue without the neurotoxic effects, proved feasible, and several trials were initiated to compare the safety and efficacy of paclitaxel/carboplatin with paclitaxel/cisplatin. The results of two of these studies that have completed accrual and reported preliminary data have shown that paclitaxel/carboplatin can be administered safely to outpatients, is better tolerated than paclitaxel/cisplatin, and results in a better quality of life. So far, the larger study (accrual, 800 patients) has yielded equal durations of progression-free survival for both the carboplatin and cisplatin combinations. If future updates of these studies confirm the current results and show similar long-term survival, the combination of carboplatin area under the concentration-time curve 5 or 6 plus paclitaxel 175 mg/m2 given over 3 hours is an attractive regimen for the treatment of newly diagnosed epithelial ovarian cancer.
Refractive index of alkali halides and its wavelength and temperature derivatives (1976)

Refractive index data for 20 alkali halides are exhaustively surveyed, compiled, and analyzed. The most probable values at 293 K for the transparent region are generated for the materials for which experimental data are sufficiently abundant and reliable. Provisional values are also provided for the wavelength regions where available data are insufficient or missing. Reasonable estimations of refractive index for the very scantily measured materials were made by incorporating the dielectric constants and wavelengths of absorption peaks into a simplified dispersion equation. Temperature derivatives of refractive index for most of the alkali halides were unavailable. However, using the existing data for the five most commonly used alkali halides, novel empirical facts were discovered and dn/dT formulas were constructed for all of the alkali halides. The calculated dn/dT values agree remarkably well with the existing experimental data.
A compact acousto-optic lens for 2D and 3D femtosecond based 2-photon microscopy (2010)

We describe a high speed 3D Acousto-Optic Lens Microscope (AOLM) for femtosecond 2-photon imaging. By optimizing the design of the 4 AO Deflectors (AODs) and by deriving new control algorithms, we have developed a compact spherical AOL with a low temporal dispersion that enables 2-photon imaging at 10-fold lower power than previously reported. We show that the AOLM can perform high speed 2D raster-scan imaging (>150 Hz) without scan rate dependent astigmatism. It can deflect and focus a laser beam in a 3D random access sequence at 30 kHz and has an extended focusing range (>137 mum; 40X 0.8NA objective). These features are likely to make the AOLM a useful tool for studying fast physiological processes distributed in 3D space.
&lt;title&gt;Switched grating devices for phased-array applications&lt;/title&gt; (1996)

Free space optical systems are described that use switchable grating technology and nonlinear materials to form digital time shifters. A cascade of n independently controlled gratings provides 2<SUP>n</SUP> evenly spaced time delay paths. Featured characteristics including potential for excellent switch isolation, spurious beam and crosstalk suppression, reduction in complexity, and low insertion loss are discussed in the context of phased array applications. Varied configurations are discussed including hybrid free- space/guided wave configurations for long time delays; transmission and double-pass digital optical time shifters; and entire array drivers that replace many single-channel time shifters with a single configuration. Using free space micro-optics, many independent time shifter configurations can be compactly stacked. A novel noise suppression device is discussed that enhances the channel isolation and signal purity of the systems.
Comparison of Metoclopramide and Erythromycin in the Treatment of Diabetic Gastroparesis (1993)

Erythromycin, a macrolide antibiotic and a motilin receptor agonist, appears to stimulate intestinal motility and seems to be an alternative agent for the treatment of gastroparesis caused by diabetic autonomic neuropathy.
InP HEMT amplifier development for G-band (140-220 GHz) applications (2002)

In this paper we describe a unique InP HEMT MMIC process that has been developed for the demonstration of the first ever G-band (140-220 GHz) amplifiers. This process combines enhanced InP HEMT profiles with a 70 nm T-gate process and a dry via etch process to achieve a high maximum gain of greater than 8 dB at 200 GHz and the highest gain amplifiers ever demonstrated (15 dB at 215 GHz).
Vancomycin Bound to Ti Rods Reduces Periprosthetic Infection (2007)

A major challenge in treating periprosthetic infection is the predilection of certain bacteria to colonize implants, form biofilms, and resist treatment. We engineered an innovative self-protective implant with covalently bound antibiotics that prevents bacterial colonization and remains stable for extended periods of time. To test this surface in vivo, we developed a rat periprosthetic infection model with an intramedullary implant in S. aureus-infected femora. Using the model, we then evaluated the effect of vancomycin-modified titanium rods on the clinical presentation of bone infection. Finally, assuming delayed and chronic periprosthetic infections originate from biofilms atop contaminated implants, the numbers of surface adherent bacteria were measured to assess the capability of the implant to prevent biofilms. S. aureus (1.5 x 10(3) colony forming units) with no known resistance were injected into the femoral canal of Wistar rats, followed by the implant. Signs of infection were assessed weekly by direct clinical observation of the animals, radiograph, and microCT, and counts of bacteria adherent to the implant. Vancomycin-modified implants showed superior inhibition of bacterial attachment and proliferation compared to control titanium surfaces.
Handling churn in a DHT (2004)

This paper addresses the problem of churn---the continuous process of node arrival and departure---in distributed hash tables (DHTs). We demonstrate through experiment that existing DHT implementations break down at churn levels observed in deployed peer-to-peer systems, contrary to simulation-based results. We present Bamboo, a DHT that handles high levels of churn, and discuss the manner in which it does so. We show that Bamboo is able to function effectively for median node session times as short as 1.4 minutes, while using less than 900 bytes/s/node of maintenance bandwidth in a 1000-node system. This churn rate is faster than that observed in real file-sharing systems such as Gnutella, Kazaa, Napster, and Overnet. Since Bamboo&amp;apos;s bandwidth usage scales logarithmically in the number of nodes, we expect this cost to remain within the reach of dialup modems even for very large systems. Moreover, in simulated networks without churn, Bamboo achieves lookup performance comparable with Pastry, an existing DHT with a similar structure.
Synthesis of Chelating Compounds to Be Used as Potential Bone Seekers<sup>1,2</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Chelating Compounds to Be Used as Potential Bone Seekers1,2Gad Shtacher and William TaubCite this: J. Med. Chem. 1966, 9, 2, 197–203Publication Date (Print):March 1, 1966Publication History Published online1 May 2002Published inissue 1 March 1966https://pubs.acs.org/doi/10.1021/jm00320a010https://doi.org/10.1021/jm00320a010research-articleACS PublicationsRequest reuse permissionsArticle Views237Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The role of the IGF‐I receptor in the growth and transformation of mammalian cells (1994)

Recent developments in the molecular biology of the insulin-like growth factor I (IGF-I) receptor have clarified its role in cellular growth and transformation. Although cells homozygous for a targeted disruption of the IGF-I receptor genes can grow in serum-supplemented medium, the IGF-I receptor is required for optimal growth, and is required equally in all phases of the cell cycle. The receptor plays an even more stringent role in cellular transformation and tumorigenicity, which seem to be dependent on its normal expression in several cell types. The expression of both the IGF-I receptor and its ligands is regulated by other growth factors (especially PDGF and EGF), by oncogenes (like SV40 T antigen and c-myb) and by tumour suppressor genes (like WT1 and RB). The picture emerging from these studies is that several transforming agents may exert their growth promoting effects through the direct or indirect activation of the IGF autocrine loop.
Effects of sodium butyrate on growth, differentiation, and apoptosis in head and neck squamous carcinoma cell lines (2000)

These results demonstrate that butyrate has activity against HNSCC in vitro and may have clinical applications for management of HNSCC patients.
ChemInform Abstract: ASYMMETRIC TRANSFORMATION OF ALANINE VIA OPTICALLY LABILE IMIDAZOLINES (1980)

Abstract Die Hydrolyse des Kondensationsprodukts (III) aus dem von S‐ oder R‐Alanin abgeleiteten Imidat (I) und dem Pyrrolidin (II) gibt R‐Alanin (Ausb. 89%; opt.
Influence of a specific 5-HT3 antagonist on carrageenan-induced hyperalgesia in rats (1989)

The effect of ICS 205-930 (ICS), a specific 5-HT3 antagonist, was studied on carrageenan (CAR)-induced rat paw inflammation to assess the involvement of endogenous released serotonin (5-HT) in the observed hyperalgesia. Studies were performed using a behavioural test, measuring the threshold stimulus necessary to elicit vocalization by gradually increasing pressure applied to the paw. When administered (s.c., in the CAR-injected paw) either 20 min before, simultaneously or 20 min after CAR, ICS (10(-11) mol/kg, i.e., 3.2 ng/kg) completely prevented the hyperalgesia in both the injected and non-injected hind paws. This effect was prolonged for 90 min, equivalent to the effect on CAR on 5-HT release. Moreover, ICS increased the vocalization threshold over the pre-drug values in normal and CAR-treated rats when injected both 20 min before and simultaneously with the polysaccharide. On the contrary, it did not reduce the hyperalgesia, when injected 2 h after CAR. ICS had no effect at any time of administration on paw oedema. These results suggest that the early inflammatory sensitization of peripheral nociceptors is mainly dependent on the release of serotonin and that the hyperalgesic effect of the monoamine involves 5-HT3(M) receptors which do not seem to be involved in the early development of oedema.
Regulation of epidermal growth factor receptor in NIH3T3/HER14 cells by antireceptor monoclonal antibodies. (1993)

The mechanism(s) by which monoclonal antibodies (mAbs) against the epidermal growth factor (EGF) receptor regulate receptor function have been investigated with NIH3T3/HER14 fibroblasts expressing human EGF receptors. Bivalent 225 mAb or monovalent 225 Fab' inhibited transforming growth factor (TGF)-alpha-induced EGF receptor tyrosine phosphorylation and cell proliferation. Culture of HER14 cells with 225 mAb or 225 Fab' did not activate EGF receptor tyrosine kinase when assayed after lysis of cells in SDS sample buffer. However, when cells were cultured with bivalent 225 mAb, but not with monovalent 225 Fab', and were subsequently lysed and further incubated in Triton X-100 lysis buffer containing proteinase and phosphatase inhibitors, receptor phosphorylation was observed. Phosphorylation was confined to tyrosine residues and was inhibited by addition of genistein after lysis, indicating that it was due to the activation of protein tyrosine kinase. The activity of bivalent 225 mAb was unphysiologic, in contrast with TGF-alpha, in that receptor kinase activation occurred only after cell lysis and with delayed kinetics; serine and threonine phosphorylation did not occur; and down-regulation of EGF receptors was slower. Selective mAb-mediated phosphorylation of tyrosine residues on EGF receptors was sufficient to activate phosphorylation of a SH2 group-bearing substrate, phospholipase C-gamma, indicating that serine/threonine phosphorylation is not required for EGF receptor kinase activity. These studies provide novel insights into the capacity of bivalent mAb to modulate EGF receptor function.
Recent advances in the chemistry of spinosyns (2001)

The spinosyns are a new class of fermentation-derived insect control agents that are effective against a variety of chewing insect pests. The successful introduction of spinosad into the agricultural marketplace represents an important milestone in the use of natural products for commercial pest control. The development of a natural product presents additional limitations relative to a synthetic material. While the latter affords some degree of control in building appropriate physical attributes such as photostability, a natural product, designed to function in a different environment, is often less suited for traditional spray applications. Despite its intrinsic photolability, spinosad is stable enough to perform under field conditions. In an effort to generate analogs with improved physical characteristics, we have developed a variety of conditions for selectively modifying different portions of the molecule, and we have discovered analogs with greater activity against a broader spectrum of pests. The inability to translate improved greenhouse activity to actual field conditions resulted in a detailed study of the effects of formulations and crystallinity on biological activity. Through this effort, measurably improved field performance of synthetic spinosyn analogs relative to the natural product have now been observed.
Degradation of fipronil by Stenotrophomonas acidaminiphila isolated from rhizospheric soil of Zea mays (2016)

Fipronil is a widely used insecticide in agriculture and can cause potential health hazards to non-target soil invertebrates and nearby aquatic systems. In the present study, a fipronil degrading bacterium was isolated from fipronil contaminated soil, i.e. rhizospheric zone of Zea mays. Morphological, biochemical and molecular characterization of strain indicated that it clearly belongs to Stenotrophomonas acidaminiphila (accession no. KJ396942). A three-factor Box-Behnken experimental design combined with response surface modeling was employed to predict the optimum conditions for fipronil degradation. The optimum pH, temperature and total inocula biomass for the degradation of fipronil were 7.5, 35 °C and 0.175 g L<sup>-1</sup>, respectively. The bacterial strain was able to metabolize 25 mg L<sup>-1</sup> fipronil with 86.14 % degradation in Dorn's broth medium under optimum conditions. Metabolites formed as a result of fipronil degradation were characterized with gas liquid chromatograph. A novel fipronil degradation pathway was proposed for S. acidaminiphila on the basis of metabolites formed. Non-sterilized soil inoculated with S. acidaminiphila was found to follow first order kinetics with a rate constant of 0.046 d<sup>-1</sup>. Fipronil sulfone, sulfide and amide were formed as the metabolites and were degraded below the quantifiable limit after 90 days of time period. Given the high fipronil degradation observed in the present study, S. acidaminiphila may have potential for use in bioremediation of fipronil contaminated soils.
Recognition of native DNA methylation by the PvuII restriction endonuclease (2000)

Recognizing the methylation status of specific DNA sequences is central to the function of many systems in eukaryotes and prokaryotes. Restriction-modification systems have to distinguish between 'self' and 'non-self' DNA and depend on the inability of restriction endonucleases to cleave their DNA substrates when the DNA is appropriately methylated. These endonucleases thus provide a model system for studying the recognition of DNA methylation by proteins. We have characterized the interaction of R.PVU:II with DNA containing the physiologically relevant N4-methylcytosine modification. R.PVU:II binds (N4m)C-modified DNA and cleaves it very slowly. Methylated strands in hemimethylated duplexes were cleaved at a higher rate than in fully methylated duplexes, in parallel with a higher binding affinity for hemimethylated DNA. The co-crystal structures of R.PVU:II-DNA, together with a mutagenesis study, have implicated specific amino acids in recognition of the methylatable base; one of these is His84. We report that replacing His84 with Ala reduced the rate of cleavage of unmodified DNA but, in contrast, slightly increased the cleavage of (N4m)C-modified DNA.
Sentiment Measured in Hospital Discharge Notes Is Associated with Readmission and Mortality Risk: An Electronic Health Record Study (2015)

Natural language processing tools allow the characterization of sentiment--that is, terms expressing positive and negative emotion--in text. Applying such tools to electronic health records may provide insight into meaningful patient or clinician features not captured in coded data alone. We performed sentiment analysis on 2,484 hospital discharge notes for 2,010 individuals from a psychiatric inpatient unit, as well as 20,859 hospital discharges for 15,011 individuals from general medical units, in a large New England health system between January 2011 and 2014. The primary measures of sentiment captured intensity of subjective positive or negative sentiment expressed in the discharge notes. Mean scores were contrasted between sociodemographic and clinical groups in mixed effects regression models. Discharge note sentiment was then examined for association with risk for readmission in Cox regression models. Discharge notes for individuals with greater medical comorbidity were modestly but significantly lower in positive sentiment among both psychiatric and general medical cohorts (p<0.001 in each). Greater positive sentiment at discharge was associated with significantly decreased risk of hospital readmission in each cohort (~12% decrease per standard deviation above the mean). Automated characterization of discharge notes in terms of sentiment identifies differences between sociodemographic groups, as well as in clinical outcomes, and is not explained by differences in diagnosis. Clinician sentiment merits investigation to understand why and how it reflects or impacts outcomes.