gebhart/patrepeval huggingface dataset:
Fractal mechanisms and heart rate dynamics (1995)

Under healthy conditions, the normal cardiac (sinus) interbeat interval fluctuates in a complex manner. Quantitative analysis using techniques adapted from statistical physics reveals the presence of long-range power-law correlations extending over thousands of heartbeats. This scale-invariant (fractal) behavior suggests that the regulatory system generating these fluctuations is operating far from equilibrium. In contrast, it is found that for subjects at high risk of sudden death (e.g., congestive heart failure patients), these long-range correlations break down. Application of fractal scaling analysis and related techniques provides new approaches to assessing cardiac risk and forecasting sudden cardiac death, as well as motivating development of novel physiologic models of systems that appear to be heterodynamic rather than homeostatic.
Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin. (1991)

Indole-3-carbinol (I3C) is a secondary plant metabolite produced in vegetables of the Brassica genus, including cabbage, cauliflower, and brussels sprouts. I3C is both an anti-initiator and a promoter of carcinogenesis. Consumption of I3C by humans and rodents can lead to marked increases in activities of cytochrome P-450-dependent monooxygenases and in a variety of phase II drug-metabolizing enzymes. We have reported previously that the enzyme-inducing activity of I3C is mediated through a mechanism requiring exposure of the compound to the low-pH environment of the stomach. We report here the aromatic hydrocarbon responsiveness-receptor Kd values (22 nM-90 nM), determined with C57BL/6J mouse liver cytosol and the in vitro- and in vivo-molar yields (0.1-6%) of the major acid condensation products of I3C. We also show that indolo[3,2-b]carbazole (ICZ) is produced from I3C in yields on the order of 0.01% in vitro and, after oral intubation, in vivo. ICZ has a Kd of 190 pM for aromatic hydrocarbon responsiveness-receptor binding and an EC50 of 269 nM for induction of cytochrome P4501A1, as measured by ethoxyresorufin O-deethylase activity in murine hepatoma Hepa 1c1c7 cells. The binding affinity of ICZ is only a factor of 3.7 x 10(-2) lower than that of the highly toxic environmental contaminant and cancer promoter 2,3,7,8-tetrachlorodibenzo-p-dioxin. ICZ and related condensation products appear responsible for the enzyme-inducing effects of dietary I3C.
Gender Stereotypes and Perceptions of Men, Women, and ‘Persons’ in the Workforce (1998)

ABSTRACT The present study, following the general approach of Broverman, Broverman, Clarkson, Rosenkrantz, and Vogel (1970, 1972), and using scales from the Bern Sex Role Inventory, examined attitudes toward men, women, and “persons” in today'S workforce. Also examined were characteristics perceived as important for masculine and feminine-typed jobs (i.e., computer programmer and nurse) and for jobs in general. Unlike the results of Broverman et al., characteristics were not evaluated differentially for men, women, or “persons.” Both masculine- and feminine-typed jobs were seen as requiring stereotypically masculine and feminine, that is, “appropriate,” characteristics. Masculine characteristics, however, were generally perceived more positively in terms of overall importance.
An Antibody for Phosphorylated Myosin Light Chain of Smooth Muscle: Application to a Biochemical Study (1994)

An antibody with specificity for the 20 kDa myosin light chain of smooth muscle phosphorylated by myosin light chain kinase was developed. The antibody was raised against the phosphorylated synthetic peptide, Lys-Lys-Arg-Pro-Gln-Arg-Ala-Thr-phospho-Ser-Asn-Val-Phe-Cys (residues 11-22 of the myosin light chain). This antibody only recognized the monophosphorylated myosin light chain at serine 19, i.e., with no detectable recognition of nonphosphorylated or diphosphorylated serine 19 or threonine 18. The specificity was tested by EIA assaying of myosin light chain kinase activity using a 96-well plate coated with the light chain. This EIA system was as sensitive as the radioisotopic method, and the newly developed non-radioisotopic method.
EUV mask patterning approaches (1999)

In the last two years, we have developed tow Extreme UV (EUV) mask fabrication process flows, namely the substractive metal and the damascene process flows, utilizing silicon wafer process tools. Both types of EUV mask have been tested in a 10X reduction EUV exposure system. Dense lines less than 100 nm in width have been printed using both 0.6 micrometers thick top surface imaging resists and ultra-thin DUV resist. The EUV masks used in EUV lithography development work have been routinely made by using the current wafer process tools. The two EUV mask processes that we have developed both have some advantages and disadvantages. The simpler subtractive metal process is compatible with the current reticle defect repair methodologies. On the other hand, the more complex damascene process facilitates mask cleaning and particle inspection.
Adding propacetamol to ketorolac increases the tolerance to painful pressure (2005)

Tolerance to repeated painful pressure (PPTT) decreased after placebo. Ketorolac 30 mg caused an increase in PPTT compared with placebo but not with baseline. Adding propacetamol 2 g to ketorolac 30 mg significantly increased PPTT. These findings support the practice of combining paracetamol with an NSAID for relief of acute pain.
Rapid Appearance of Resolvin Precursors in Inflammatory Exudates: Novel Mechanisms in Resolution (2008)

Resolution of inflammation is essential. Although supplementation of omega-3 fatty acids is widely used, their availability at sites of inflammation is not known. To this end, a multidisciplinary approach was taken to determine the relationship of circulating omega-3 to inflammatory exudates and the generation of resolution signals. In this study, we monitored resolvin precursors in evolving exudates, which initially paralleled increases in edema and infiltrating neutrophils. We also prepared novel microfluidic chambers to capture neutrophils from a drop of blood within minutes that permitted single-cell monitoring. In these, docosahexaenoic acid-derived resolvin D1 rapidly stopped neutrophil migration, whereas precursor docosahexaenoic acid did not. In second organ injury via ischemia-reperfusion, resolvin metabolically stable analogues were potent organ protectors reducing neutrophils. Together, these results indicate that circulating omega-3 fatty acids rapidly appear in inflammatory sites that require conversion to resolvins that control excessive neutrophil infiltration, protect organs, and foster resolution.
Enzyme engineering aspects of biocatalysis: Cofactor regeneration as example (1996)

Reaction engineering is an important tool in the case of cofactor depending enzyme-catalyzed reactions. It allows the establishment of conditions resulting in lower product specific cofactor costs as compared with product-specific enzyme costs. This is shown for the stereospecific reduction of carbonyl compounds yielding chiral amino acids and alcohols. In continuous processes, cofactor costs can be reduced if the cofactor can be retained within the bioreactor or recycled into it after separation of the product. In case of readily water-soluble substrates it is even possible to recycle the cofactor during a single pass through a continuously operated reactor more than 4000 times because normally very low cofactor concentrations are sufficient to saturate the enzymes involved. L-tert-Leucine has been produced by reductive amination with a space-time yield of up to 366 g L−1 d−1 in a single continuously operated enzyme membrane reactor and a two-stage cascade. Total turnover number of the cofactor NAD+ increased to 4230. (S)-1-Phenyl-2-propanol was obtained by reduction of the corresponding ketone in an membrane reactor with integrated extraction of the product. A new alcohol dehydrogenase from Rhodococcus erythropolis was used. A space-time yield of 63 g L−1 d−1 and a total turnover number of 1350 have been reached. L-Leucine has been produced using polymer-enlarged NADH. The total turnover number was 80,000 at a space-time yield of 214 g L−1 d−1. © 1996 John Wiley & Sons, Inc.
Synthetic Studies Towards Novel Terpenic Natural Products Kelsoene and Poduran: Construction of the Complete 4-5-5-Fused Tricarbocyclic Core (1999)

A common synthetic approach to the recently reported sesquiterpene kelsoene 1 and the tetraterpene poduran 5, bearing a novel tricyclo[6.2.0.02,6]decane framework, from commercially available 1,5-COD and leading to the first construction of the carbocyclic core present in these natural products is delineated.
The Surface Coat of the Mammal-dwelling Infective Trypomastigote Stage of Trypanosoma cruzi Is Formed by Highly Diverse Immunogenic Mucins (2004)

A thick coat of mucin-like glycoproteins covers the surface of Trypanosoma cruzi and plays a crucial role in parasite protection and infectivity and host immunomodulation. The appealing candidate genes coding for the mucins of the mammal-dwelling stages define a heterogeneous family termed TcMUC, which comprises up to 700 members, thus precluding a genetic approach to address the protein core identity. Here, we demonstrate by multiple approaches that the TcMUC II genes code for the majority of trypomastigote mucins. These molecules display a variable, non-repetitive, highly O-glycosylated central domain, followed by a short conserved C terminus and a glycosylphosphatidylinositol anchor. A simultaneous expression of multiple TcMUC II gene products was observed. Moreover, the C terminus of TcMUC II mucins, but not their central domain, elicited strong antibody responses in patients with Chagas' disease and T. crusi infected animals. This highly diverse coat of mucins may represent a refined parasite strategy to elude the mammalian host immune system.
Mixtures of Dirichlet Processes with Applications to Bayesian Nonparametric Problems (1974)

A random process called the Dirichlet process whose sample functions are almost surely probability measures has been proposed by Ferguson as an approach to analyzing nonparametric problems from a Bayesian viewpoint. An important result obtained by Ferguson in this approach is that if observations are made on a random variable whose distribution is a random sample function of a Dirichlet process, then the conditional distribution of the random measure can be easily calculated, and is again a Dirichlet process. This paper extends Ferguson's result to cases where the random measure is a mixing distribution for a parameter which determines the distribution from which observations are made. The conditional distribution of the random measure, given the observations, is no longer that of a simple Dirichlet process, but can be described as being a mixture of Dirichlet processes. This paper gives a formal definition for these mixtures and develops several theorems about their properties, the most important of which is a closure property for such mixtures. Formulas for computing the conditional distribution are derived and applications to problems in bio-assay, discrimination, regression, and mixing distributions are given.
A Dynamic Noise Primitive for Coherent Stylization (2010)

Abstract We present a new solution for temporal coherence in non‐photorealistic rendering (NPR) of animations. Given the conflicting goals of preserving the 2D aspect of the style and the 3D scene motion, any such solution is a tradeoff. We observe that primitive‐based methods in NPR can be seen as texture‐based methods when using large numbers of primitives, leading to our key insight, namely that this process is similar to sparse convolution noise in procedural texturing. Consequently, we present a new primitive for NPR based on Gabor noise, that preserves the 2D aspect of noise, conveys the 3D motion of the scene, and is temporally continuous. We can thus use standard techniques from procedural texturing to create various styles, which we show for interactive NPR applications. We also present a user study to evaluate this and existing solutions, and to provide more insight in the trade‐off implied by temporal coherence. The results of the study indicate that maintaining coherent motion is important, but also that our new solution provides a good compromise between the 2D aspect of the style and 3D motion.
Piperazine derivatives of benzimidazole as potential anthelmintics. Part 1: Synthesis and activity of methyl-5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates. (1989)

A series of 5-(4-substituted piperazin-1-yl)-2-nitroanilines (4) and 5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates (6) has been synthesized starting from 5-chloro-2-nitroaniline (3) and N-monosubstituted piperazines. Catalytic reduction of 4 with Pd/C followed by treatment with 1,3-dicarbomethoxy-S-methylisothiourea yielded the corresponding methyl-5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates (6) which were for anthelmintic activity against experimental infections of Trichinella spiralis.
An Indexing And Browsing System For Home Video (2000)

Publication in the conference proceedings of EUSIPCO, Tampere, Finland, 2000
Mining data records in Web pages (2003)

A large amount of information on the Web is contained in regularly structured objects, which we call data records. Such data records are important because they often present the essential information of their host pages, e.g., lists of products or services. It is useful to mine such data records in order to extract information from them to provide value-added services. Existing automatic techniques are not satisfactory because of their poor accuracies. In this paper, we propose a more effective technique to perform the task. The technique is based on two observations about data records on the Web and a string matching algorithm. The proposed technique is able to mine both contiguous and non-contiguous data records. Our experimental results show that the proposed technique outperforms existing techniques substantially.
Ectodomain Shedding and Autocleavage of the Cardiac Membrane Protease Corin (2011)

Corin is a cardiac membrane protease that activates natriuretic peptides. It is unknown how corin function is regulated. Recently, soluble corin was detected in human plasma, suggesting that corin may be shed from cardiomyocytes. Here we examined soluble corin production and activity and determined the proteolytic enzymes responsible for corin cleavage. We expressed human corin in HEK 293 cells and detected three soluble fragments of ∼180, ∼160, and ∼100 kDa, respectively, in the cultured medium by Western blot analysis. All three fragments were derived from activated corin molecules. Similar results were obtained in HL-1 cardiomyocytes. Using protease inhibitors, ionomycin and phorbol myristate acetate stimulation, small interfering RNA knockdown, and site-directed mutagenesis, we found that ADAM10 was primarily responsible for shedding corin in its juxtamembrane region to release the ∼180-kDa fragment, corresponding to the near-entire extracellular region. In contrast, the ∼160- and ∼100-kDa fragments were from corin autocleavage at Arg-164 in frizzled 1 domain and Arg-427 in LDL receptor 5 domain, respectively. In functional studies, the ∼180-kDa fragment activated atrial natriuretic peptide, whereas the ∼160- and ∼100-kDa fragments did not. Our data indicate that ADAM-mediated shedding and corin autocleavage are important mechanisms regulating corin function and preventing excessive, potentially hazardous, proteolytic activities in the heart.
INSTRUMENTATION OF A LINUX-BASED MOBILE DEVICE (2015)

Sensitive information are extensively stored and handled in users’ mobile devices that sets challenges in terms of information security. One of the main targets of malicious mobile applications is to steal sensitive information. Mobile devices need tools and mechanisms to provide visibility how applications access sensitive system resources and handle information. Security assessment for a randomly selected application in a resource-constrained mobile environment requires an overall understanding of the target system and might involve a significant amount of work for selecting a suitable monitoring method. This thesis presents two extensions on top of general purpose instrumentation tools. The instrumentation tools and developed extensions are executed on a Linux-based mobile device in order to monitor the behavior of applications. An application monitor extension is used for providing an overview of system resource usage by monitored application. Network monitor extension is used for analyzing content of the network traffic in real-time for selected application layer protocols. Additionally application layer data is monitored from intercepted secure connections based on user defined keywords. Developed instrumentation extensions were successfully used in a Linux-based mobile device to monitor applications’ resource access and sensitive information from outbound network traffic. The approach selected for real-time network traffic analysis provided promising results while not causing significant performance problems for the mobile device.
Content Protection for IPTV-current state of the art and challenges (2006)

With the rapid deployment of IPTV services on the Internet, content protection has become an extremely important issue and raised much concern. IP CAS and IP DRM are two primary content protection technologies in this field at present. In this paper, a detailed analysis of principles and implementations of the two techniques is given, and the comparison and contrast between them are also carefully made. In the end, we provide some challenges and potential trend and research topics in this area
Measurement of tissue perfusion by dynamic computed tomography (1991)

A method for quantifying tissue perfusion by dynamic computed tomography (CT) is described. By applying a nuclear medicine data processing technique to time-density data from a single-location dynamic CT sequence, tissue perfusion can be determined from the maximum gradient of the tissue time-density curve divided by the peak enhancement of the aorta. Using this method, splenic perfusion was measured at 1.2 ml min-1 ml-1, normal renal cortical perfusion at 2.5 ml min-1 ml-1 and normal renal medullary perfusion at 1.1 ml min-1 ml-1. Changes in cortical and medullary perfusion in renal failure and hypertension were demonstrated. The ability of dynamic CT to provide quantitative functional information is not well recognized and is potentially of value when studying structures, such as the renal cortex and medulla, that cannot be anatomically resolved by standard functional imaging techniques.
Identification of Defensin α6 as a Potential Biomarker in Colon Adenocarcinoma (2004)

There is substantial interest in the identification of circulating human tumor-derived proteins in serum for the purposes of early cancer diagnosis. We have implemented an approach based on the analysis of microarray data for the identification of tumor proteins that may have utility as biomarkers in colon cancer. Expression analysis of microarray data obtained from a variety of 283 tumors and normal tissues revealed that defensin alpha6 was maximally expressed in colon cancer. These findings were corroborated by reverse transcription-PCR, in which the colon cancer cell lines LoVo, Caco2, HCT-15, SW480, and SW620 showed significantly higher levels of defensin alpha6 expression than did non-colon cancer cell lines. Moreover, our data were concordant with data obtained from the NCI, National Institutes of Health Cancer Genome Anatomy Project. To evaluate defensin alpha6 as a potential biomarker of colon cancer, a preliminary "training" set of serum from 91 healthy donors and 109 colon cancer patients was analyzed by enzyme-linked immunosorbent assay. The data pattern was confirmed by an independent set of 67 masked serum samples: 18 from healthy donors and 49 from colon cancer patients. This result yielded a sensitivity of 69.4% (95% CI 54.6-81.8), specificity of 83.3% (58.6-96.4), and positive predictive value of 91.9% (78.1-98.3). These findings justify a prospective assessment of serum defensin alpha6 protein as a screening tool for colon cancer.
Creatine-Kinase- and Exercise-Related Muscle Damage Implications for Muscle Performance and Recovery (2012)

The appearance of creatine kinase (CK) in blood has been generally considered to be an indirect marker of muscle damage, particularly for diagnosis of medical conditions such as myocardial infarction, muscular dystrophy, and cerebral diseases. However, there is controversy in the literature concerning its validity in reflecting muscle damage as a consequence of level and intensity of physical exercise. Nonmodifiable factors, for example, ethnicity, age, and gender, can also affect enzyme tissue activity and subsequent CK serum levels. The extent of effect suggests that acceptable upper limits of normal CK levels may need to be reset to recognise the impact of these factors. There is a need for standardisation of protocols and stronger guidelines which would facilitate greater scientific integrity. The purpose of this paper is to examine current evidence and opinion relating to the release of CK from skeletal muscle in response to physical activity and examine if elevated concentrations are a health concern.
Unsupervised document classification using sequential information maximization (2002)

We present a novel sequential clustering algorithm which is motivated by the Information Bottleneck (IB) method. In contrast to the agglomerative IB algorithm, the new sequential (sIB) approach is guaranteed to converge to a local maximum of the information with time and space complexity typically linear in the data size. information, as required by the original IB principle. Moreover, the time and space complexity are significantly improved. We apply this algorithm to unsupervised document classification. In our evaluation, on small and medium size corpora, the sIB is found to be consistently superior to all the other clustering methods we examine, typically by a significant margin. Moreover, the sIB results are comparable to those obtained by a supervised Naive Bayes classifier. Finally, we propose a simple procedure for trading cluster's recall to gain higher precision, and show how this approach can extract clusters which match the existing topics of the corpus almost perfectly.
대학생의 발테그 그림검사(WZT) 반응특성에 관한 연구 (2016)

본 연구는 대학생의 발테그 그림검사 반응특성을 파악하고, 성별에 따른 차이를 알아보고자 하였다. 이를 위하여 수도권 대학에 재학 중인 대학생 247명에게 발테그 그림검사(Wartegg-Zeichentest: WZT)를 실시하였다. 분석기준은 아우구스트 페터(August Vetter)의 현상학적인 해석을 토대로 평가항목을 재구성하였고, 자료 분석은 빈도분석,...
Immunotoxins and Other Conjugates: Preparation and General Characteristics (2004)

Targeted toxins represent an invaluable tool offering a wide range of potential applications, both in experimental models and in the clinics. Here we will review several aspects related to the preparation and properties of carrier molecule-toxin heteroconjugates and fusion toxins.
Salmonella as an intracellular parasite (1989)

Salmonella species are facultative intracellular parasites, capable of penetrating (invading), surviving, and often multiplying within diverse eukaryotic cell types, including epithelial and phagocytic cells. These processes are essential for virulence, and involve both bacterial and host cell products. The use of cultured eukaryotic cells and other model systems has facilitated the study of bacterial-host cell interactions, and has led to a better understanding of the genetic and molecular basis of Salmonella pathogenicity.