gebhart/patrepeval huggingface dataset:
Double-blind, randomized, controlled study on the efficacy and safety of a novel diclofenac epolamine gel formulated with lecithin for the treatment of sprains, strains and contusions. (2003)

To evaluate the efficacy of the new diclofenac-N-(2-hydroxyethyl)-pyrrolidine gel formulated with lecithin (DHEP lecithin) compared with diclofenac-N-(2-hydroxyethyl)-pyrrolidine gel (DHEP gel) without lecithin in mild-to-moderate posttraumatic injuries (grade 1 ankle, knee and muscle injuries), a multicenter, double-blind, controlled study was carried out. A total of 100 patients were enrolled and randomly assigned to either DHEP lecithin (n = 52) or DHEP gel (n = 48) treatment. All patients concluded the treatment period except for five, who did not turn up to their respective investigational sites for the follow-up visits. According to an intention-to-treat approach, they were all included in the statistical analysis. As for the efficacy and safety analysis, the primary variable was "pain on movement" as measured by a Huskisson visual analog scale. During the first 3 days of treatment each group recorded a significant within-group decrease, but patients treated with DHEP lecithin showed a decrease in absolute value that was statistically greater than that obtained with DHEP gel (p = 0.025). At the end of the treatment period (day 10) the difference between groups was still statistically significant (p = 0.036). The statistical analysis of the secondary efficacy variables showed significant results in favor of DHEP lecithin treatment. These were superimposable on the results found for the primary variable. The global efficacy and tolerability judgments, reported either by patient or by physician, showed no statistical difference between treatment groups. Due to the presence of lecithin in the new gel formulation, DHEP lecithin showed a faster and significantly more marked therapeutic effect compared with that of DHEP gel.
An update on mechanical circulatory support for heart failure therapy (2014)

There has been a dramatic advancement of durability found in the second and third-generation, continuous flow LVADs, along with improved survival rates in patients receiving these devices for destination therapy. MCS may soon become the treatment option of choice in refractory heart failure patients, especially with further evolution of less invasive approaches, smaller designs, and energy sources.
Usefulness of carcinoembryonic antigen measurement in feces of patients with colorectal cancer (1987)

Anticarcinoembryonic antigen (CEA) antisera which showed no reactions with normal adult feces were prepared in guinea pigs. Using these, levels of CEA in feces from patients with colorectal carcinoma were measured by gel diffusion and rocket immunoelectrophoresis. Sixteen of 22 (73 percent) patients with carcinoma of the colon or rectum (Dukes' A4/6, B6/8, C6/7, D0/1) had detectable CEA in their feces, while none was detected in the feces of four patients with gastric ulcers or in those of 22 normal volunteers. Five of the 16 fecal CEA-positive patients showed no elevation of plasma CEA levels. Measurements using a commercial CEA kit (Abbott Laboratories) could not detect the differences between fecal CEA values of patients with colorectal carcinoma and benign diseases, or those of normal volunteers. These results suggest that measurement of fecal CEA by specific anti-CEA antisera will be valuable in screening and diagnosis of colorectal carcinoma.
Fourier transform ion cyclotron resonance mass spectrometry: the teenage years (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFourier transform ion cyclotron resonance mass spectrometry: the teenage yearsAlan G. Marshall and Peter B. GrosshansCite this: Anal. Chem. 1991, 63, 4, 215A–229APublication Date (Print):February 15, 1991Publication History Published online22 September 2008Published inissue 15 February 1991https://pubs.acs.org/doi/10.1021/ac00004a001https://doi.org/10.1021/ac00004a001research-articleACS PublicationsRequest reuse permissionsArticle Views770Altmetric-Citations189LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Novel Autologous Cell Therapy in Ischemic Limb Disease Through Growth Factor Secretion by Cultured Adipose Tissue–Derived Stromal Cells (2005)

These adipose tissue-derived cells demonstrated potential as angiogenic cell therapy for ischemic disease, which appears to be mainly achieved by their ability to secrete angiogenic growth factors.
Single Machine Scheduling to Minimize Total Late Work (1992)

In the problem of scheduling a single machine to minimize total late work, there are n jobs to be processed for which each has an integer processing time and a due date. The objective is to minimize the total late work, where the late work for a job is the amount of processing of this job that is performed after its due date. For the preemptive total late work problem, an O(n log n) algorithm is derived. The nonpreemptive total late work problem is shown to be NP-hard, although efficient algorithms are derived for the special cases in which all processing times are equal and all due dates are equal. A pseudopolynomial dynamic programming algorithm is presented for the general nonpreemptive total late work problem; it requires O(nUB) time, where UB is any upper bound on the total late work. Computational results for problems with up to 10,000 jobs are given.
Ultraviolet downconverting phosphor for use with silicon CCD imagers (1980)

The properties and application of a UV downconverting phosphor (coronene) to silicon charge coupled devices are discussed. Measurements of the absorption spectrum have been extended to below 1000 A, and preliminary results indicate the existence of useful response to at least 584 A. The average conversion efficiency of coronene was measured to be ~20% at 2537 A. Imagery at 3650 A using a backside illuminated 800 x 800 CCD coated with coronene is presented.
Primary structure of bovine collectin-43 (CL-43). Comparison with conglutinin and lung surfactant protein-D. (1994)

Collectin-43 (CL-43) is a bovine serum protein that is composed of subunits of three identical chains, each of which contains a collagen region and a C-type carbohydrate recognition domain; thus, CL-43 belongs to the collectins (group III of the C-type lectins). We have derived the complete primary sequence of CL-43 using partial protein sequencing, cDNA cloning, and reverse transcription-polymerase chain reaction techniques. The primary sequence of CL-43 shows that it contains an N-terminal region of 28 residues, followed by a collagenous domain of 38 repeats of Gly-Xaa-Yaa and then a C-terminal section of 159 residues, containing a short "neck" region and the carbohydrate recognition domain with the conserved residues found in all C-type lectins. The amino acid sequence of CL-43 showed 74% identity to bovine conglutinin and 70% identity to bovine lung surfactant protein D (SP-D), but the collagen region is considerably shorter than the 57 Gly-Xaa-Yaa triplets found in conglutinin and SP-D. Northern blot analysis showed that CL-43 was only synthesized in bovine liver, with no detectable signal in a variety of other bovine tissues, including lung. No cross-hybridizing signals were detected in mRNA from sheep, human, rat, or mouse liver. Since CL-43 and conglutinin have only been detected in members of bovidae, it is probable that an ancestral gene of these two proteins was first derived from a SP-D-like gene, and that this ancestral gene duplicated during evolution.
Políticas de comunicación (1988)

Asistimos a la era de los satélites, nueva industria millonaria empujada por razones políticas y comerciales por un grupo de de gobiernos y consorcios transnacionales. Así los que tienen el control del espacio y de las telecomunicaciones dominan al resto. En el campo de los satélites, los países del Tercer Mundo tienen todas las de perder sin tecnologías, sin satélites y sin grandes capitales no se puede competir.
Small Molecule Protein-Protein Inhibitors for the p53-MDM2 Interaction (2007)

This article describes recent progress in the development of small molecule protein-protein inhibitors of the p53-MDM2 (purine double minute 2, or HDM2 for the human congener) protein-protein interaction, with special attention to the diversity of chemotypes reported to disrupt this protein-protein interaction. In >50% of all human cancers, the tumor suppressor 53 KDa phospho-protein p53 is either mutated or deleted. The discovery that MDM2 (HDM2) negatively regulates p53 and therefore inhibits the tumor-suppressor activity of p53 has instigated numerous drug discovery campaigns aimed at disrupting this protein-protein interaction as a potential cancer therapy. Once regarded as intractable targets disrupted by only large macromolecules, protein-protein interactions (PPI) are now mainstream targets due in large part to the intensive effort applied to the study of p53 and the surprising diversity of small molecules (peptides, natural products, terphenyl and other alpha-helix mimetics, chalcones, piperidines, piperazines, fused indoles, isoindolinones, spiro-oxindoles, cis-imidazolines (nutlins), quinolinol and benzodiazepines) capable of disrupting the p53-HDM2 PPI. In addition, drug discovery researchers have employed a number of screening approaches and technologies to identify SMPPIs of the p53-HDM2 interaction, and these discovery paradigms will be discussed. This review will detail the biology of the p53-MDM2 interaction, the major classes of SMPPIs and key medicinal chemistry and in vitro/in vivo biological data reported through October 2006.
Balanced antipodal Vivaldi antenna for wide bandwidth phased arrays (1996)

The Vivaldi antenna, a form of tapered slot radiator, has been shown to produce good performance over a wide bandwidth, limited only by the traditionally used slotline to microstrip feed transition. The authors present a new antenna, the balanced antipodal Vivaldi, which incorporates an ultrawide bandwidth transition and overcomes the poor polarisation performance of the antipodal form. Good performance over a 1 to 40 frequency range has been obtained. The use of the antenna in a linear phased array has also been investigated using elements constructed on high permittivity substrate. Wideband wide angle scanning with good cross-polarisation levels is obtained.
Notes on the History of Clinical Sociology at Yale (1989)

This article recounts one version of the attempt to create a department of clinical sociology in the Medical School of Yale University in the late 1920s. The theoretical perspective of Alfred Schutz is used to turn attention to the linkages of generations of sociologists reflected in the construction of our history as told to young sociologists by their elders. Historical documents and the recollections of John Dollard are used to recount the history of attempts to develop support for the Institute of Human Relations, including a department of clinical sociology at Yale Medical School. The idea was supported by Dean Winternitz of the School of Medicine, but drew powerful opposition from other Departments at Yale and from Abraham Flexner, whose report on American medical schools set the course of medical education in America.
Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML (2006)

In acute myeloid leukemia (AML), two clusters of activating mutations are known in the FMS-like tyrosine kinase-3 (FLT3) gene: FLT3-internal tandem duplications (FLT3-ITDs) in the juxtamembrane (JM) domain in 20% to 25% of patients, and FLT3 point mutations in the tyrosine-kinase domain (FLT3-TKD) in 7% to 10% of patients, respectively. Here, we have characterized a new class of activating point mutations (PMs) that cluster in a 16-amino acid stretch of the juxtamembrane domain of FLT3 (FLT3-JM-PMs). Expression of 4 FLT3-JM-PMs in interleukin-3 (IL-3)-dependent Ba/F3 cells led to factor-independent growth, hyperresponsiveness to FLT3 ligand, and resistance to apoptotic cell death. FLT3-JM-PM receptors were autophosphorylated and showed a higher constitutive dimerization rate compared with the FLT3-wild-type (WT) receptor. As a molecular mechanism, we could show activation of STAT5 and up-regulation of Bcl-x(L) by all FLT3-JM-PMs. The FLT3 inhibitor PKC412 abrogated the factor-independent growth of FLT3-JM-PM-expressing cells. Compared with FLT3-ITD and FLT3-TKD mutants, the FLT3-JM-PMs showed a weaker transforming potential related to lower autophosphorylation of the receptor and its downstream target STAT5. Mapping of the FLT3-JM-PMs on the crystal structure of FLT3 showed that these mutations reduce the stability of the autoinhibitory JM domain, and provides a structural basis for the transforming capacity of this new class of gain-of-function mutations of FLT3.
Uncalibrated, absolute property estimation and measurement optimization for conducting and magnetic media using imposed [omega]-k magnetometry (1990)

Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1991.
Integration of Optical Polymer Pillars Chip I/O Interconnections with Si MSM Photodetectors (2004)

We demonstrate the process integration and characterization of mechanically compliant optical polymer pillar chip I/O interconnections with Si metal-semiconductor-metal photodetectors (MSM-PDs). Polymer pillar waveguides with various cross-sectional geometry, size, and aspect ratio are fabricated on the active area of Ti-Si-Ti MSM-PDs. Some of the key performance metrics of the MSM-PDs before and after the process integration are reported. It is shown that the dark current of passivated Ti-Si-Ti PDs does not degrade as a result of the processing required to fabricate the polymer pillar I/O interconnections. In addition, the pillar integration does not degrade the responsivity as well as the normalized photo-to-dark current ratio of the MSM-PDs.
Dissecting the Fidelity of Bacteriophage RB69 DNA Polymerase: Site-Specific Modulation of Fidelity by Polymerase Accessory Proteins (2002)

Bacteriophage RB69 encodes a replicative B-family DNA polymerase (RB69 gp43) with an associated proofreading 3' exonuclease. Crystal structures have been determined for this enzyme with and without DNA substrates. We previously described the mutation rates and kinds of mutations produced in vivo by the wild-type (Pol(+) Exo(+)) enzyme, an exonuclease-deficient mutator variant (Pol(+) Exo(-)), mutator variants with substitutions at Tyr(567) in the polymerase active site (Pol(M) Exo(+)), and the double mutator Pol(M) Exo(-). Comparing the mutational spectra of the Pol(+) Exo(-) and Pol(+) Exo(+) enzymes revealed the patterns and efficiencies of proofreading, while Tyr(567) was identified as an important determinant of base-selection fidelity. Here, we sought to determine how well the fidelities of the same enzymes are reflected in vitro. Compared to their behavior in vivo, the three mutator polymerases exhibited modestly higher mutation rates in vitro and their mutational predilections were also somewhat different. Although the RB69 gp43 accessory proteins exerted little or no effect on total mutation rates in vitro, they strongly affected mutation rates at many specific sites, increasing some rates and decreasing others.
Effect of nanotube alignment on percolation conductivity in carbon nanotube/polymer composites (2005)

Percolation conductivity of a stick network depends on alignment as well as concentration. We show that both dependences exhibit critical (power-law) behavior, and study the alignment threshold in detail. The highest conductivity occurs for slightly aligned, rather than isotropic, sticks. Experiments on single wall carbon nanotube composites are supported by Monte Carlo simulations. These results should be broadly applicable to percolating networks of anisotropic conductors.
Investigation of glucose-modified liposomes using polyethylene glycols with different chain lengths as the linkers for brain targeting (2012)

The data indicated that GLU400-LIP, GLU1000-LIP, and GLU2000-LIP all possess the potential of brain targeting, among which GLU1000-LIP, as a promising drug-delivery system, exhibited the strongest brain delivery capacity.
Structure of a PDMS Layer Grafted onto a Silica Surface Studied by Means of DSC and Solid-State NMR (2002)

The structure of a poly(dimethylsiloxane) (PDMS) layer at the surface of hydrophilic silica has been studied by means of DSC, proton NMR T2 relaxation experiments, and 1H and 29Si NMR spectroscopy. The samples were prepared using (1) the adsorption of PDMS from a PDMS solution onto the silica surface followed by a thermal treatment and (2) mechanical mixing of PDMS with the silica followed by the separation of bound rubber. It was shown that these procedures caused the formation of chain loops chemically attached to the silica surface at both chain ends. The average length of the grafted chains varied from about four to eight Si−O bonds. The experiments provided information on the mobility of the grafted chains, which is related to the structure of the grafted layer. The grafted PDMS layer was found to consist of immobilized chain segments at the PDMS−silica interface and mobile chain portions outside the interface. The chain immobilization at the interface caused a substantial decrease in the heat capacity at Tg and suppressed crystallinity of the grafted PDMS. The interface fraction increased proportionally with a decreasing chain length. About four dimethylsiloxane pendant chain units next to the grafting site were immobilized due to chain anchoring to the silica surface. A small fraction of −SiO(CH3)2− chain units was immobilized as a result of physical adsorption at the silica surface. The fraction of physically adsorbed chain units appears to be proportional to the number of residual silanol groups at the silica surface. The mobility of the chain portions outside the interface was found to differ significantly in the various samples studied and to increase with an increasing average length of the grafted chains. The NMR method allowed us to make a distinction between a dense “brushlike” structure of the grafted layer containing grafted chains of a fairly uniform length and a layer containing a significant fraction of long chain loops outside the densely grafted layer. It was found that the structure of the grafted layer is to a great extent dependent on the grafting procedure employed.
The Use of Computer Modeling in Room Acoustics (2000)

: After decades of development room acoustical computer models have matured. Hybrid methods combine the best features from image source models and ray tracing methods and have led to significantly reduced calculation times. Due to the wave nature of sound it has been necessary to simulate scattering effects in the models. Today&amp;apos;s room acoustical computer models have several advantages compared to scale models. They have become reliable and efficient design tools for the acoustic consultants, and the results of a simulation can be presented not only for the eyes but also for the ears with new techniques for auralisation. Keywords: room acoustics, computer models, scattering, auralisation NOTATION c speed of sound in air i reflection order n number of surfaces s scattering coefficient of a surface t time A area of a surface in a room N number of rays N refl number of reflections N sou number of image sources V volume of room 1. INTRODUCTION In acoustics as in many other ar...
Passivation Effect of Poly-Si Thin-Film Transistors With Fluorine-Ion-Implanted Spacers (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> In this letter, polycrystalline silicon thin-film transistors (TFTs) consisting of lightly doped drain structure and fluorine-ion-implanted spacers were investigated for the passivation effect under the hot carrier stress. The dose and distribution of fluorine are exhibited by secondary ion mass spectrometry analysis. We could use this method to provide enough fluorine atoms to passivate the defects between the <formula formulatype="inline"> <tex>$\hbox{N}^{-}$</tex></formula> regime and the conduction channel. Moreover, the TFTs with fluorine-ion-implanted spacers have better electrical characteristics than the standard device for resisting the degradation effects of hot carrier, such as smaller degradation of transconductance, current crowding effect, and subthreshold slope. </para>
A Comprehensive Knock Model for Application in Gas Engines (1996)

&lt;div class="htmlview paragraph"&gt;A predictive knock model that utilizes a phenomenological modeling approach has been developed for predicting the onset of knock in gas engines. Several physical models have been developed and incorporated into WAVE, a comprehensive engine simulation code, including 1) a spatially resolved end gas thermodynamics model; 2) a model for calculating the chemical reaction rates of the reactants in the unburned zone; and 3) a model for approximating the heat transfer between the two-zone combustion model and end gas reaction model.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The established predictive knock model has been demonstrated and validated against experimental data. A WAVE simulation model of the Caterpillar G3508 engine was created and used to predict engine knock over a range of fuels, spark timing and compression ratios. The computational results are compared to test data which were obtained from G3508 detonation timing test. Overall, good correlation was achieved between measured data by Caterpillar and data predicted by WAVE. Finally, a parametric study was performed to evaluate the effects of compression ratio on engine knock performance. Based on the parametric study performed, the knock limited compression ratio can be identified for the G3508 engine under a specified operating condition.&lt;/div&gt;
Growth hormone treatment in children with Noonan's syndrome: four year results of a partly controlled trial (2001)

This study confirmed the gain in H-SDS CA in Noonan's syndrome during long-term GH treatment. However, the accelerating effect of GH on bone maturation seemed to compromise the final height prognosis.
Gallium Doping For Silicon Etch Stop In Koh (2005)

The dopant concentration dependence of the etch rate of Gallium doped silicon in KOH solutions is presented, and compared to results previously reported for Boron. Silicon samples were ion implanted with Gallium to obtain concentrations comparable to Boron concentrations where etch rate significantly decreases, i.e. > 10/sup 19/ cm/sup -3/. Results show that allium and Boron produce similar etch stop effects in silicon; both are capable of reducing the etch rate by as much as 40 times in KOH. However, their respective activation energies were found to be considerably different at high dopant concentrations.