gebhart/patrepeval huggingface dataset:
Synthesis of vitamin K‐dependent proteins (1993)

The unique and characteristic feature of vitamin K-dependent proteins is the presence of gamma-carboxyglutamyl (Gla) residues formed during the posttranslational processing of these proteins. The energy needed to drive this microsomal carboxylation event comes from the reoxidation of the reduced, hydronaphthoquinone form of vitamin K to its 2,3-epoxide. Recent studies have suggested that an intermediate epoxide alkoxide is the strong base needed to abstract a proton from the relatively unreactive methylene carbon of the glutamyl residue. The primary gene product of the vitamin K-dependent proteins contains a homologous propeptide extension between the amino terminus of the mature protein and signal peptide. This region, which is cleaved before secretion of these proteins, serves to dock the protein substrate to the enzyme catalyzing the carboxylation event, and to also alter the apparent Km of the Glu binding site of the enzyme. The order in which the multiple Glu sites on the substrate proteins are carboxylated is unknown, but elucidation of this property of the enzyme and further details of the bioorganic mechanism should be aided by recent reports of purification of this unique carboxylase.
Antithymocyte globulin as the primary treatment for renal allograft rejection. (1983)

La globuline anti-thymocytes est un traitement efficace en cas de rejet de rein greffe. Quelques malades demandent en plus un traitement par corticoides, mais le traitement immunodepresseur se trouve reduit. Le GAT devient le traitement principal de l'episode de rejet
Explanation of anomalous loss in high delta singlemodefibres (1999)

An explanation is provided for the anomalous loss observed in singlemode optical fibres when the refractive index between the core and the cladding is increased and the core diameter is decreased.
Radioimmunoassay of plasma renin activity. (1976)

We describe a sensitive, simplified radioimmunoassay method for determination of plasma renin activity. Plasma was acidified to the optimal pH (6.0) of angiotensin l generation with the least possible dilution, by using a single addition of hydrochloric acid and the enzyme inhibitor hydroxyquinoline. Recovery of unlabeled angiotensin l added to plasma was 92-97%; that of monoiodinated angiotensin l exceeded 90%, indicating satisfactory protection from proteolytic enzymes. Plasma constituents interfered little with the radioimmunoassay. Bland values for plasma kept at 0 degrees C were 10.7 +/- 2.3 (mean +/- SD) percent of the activity values for samples kept at +37 degrees C (n equals 63). In the routine setting, 6.25 pg of angiotensin l or 10(-6) Goldblatt units of Standard Human Renin was detected. We report results of plasma renin activity measurements and a comparison with seven renin kits, and with bioassay for plasma renin activity.
Addition of a channel mechanism to the ideal-observer model (1987)

Several authors have measured the detection ability of human observers for objects in correlated (nonwhite) noise. These studies have shown that the human observer has approximately constant efficiency when compared with a nonprewhitening ideal observer. In this paper we add a frequency-selective mechanism to the ideal-observer model, similar to the channel mechanism that has been demonstrated through experiments that measure a subject's ability to detect grating stimuli. For a number of detection and discrimination tasks, the nonprewhitening ideal-observer model and the channelized ideal-observer model yield similar performance predictions. Thus both models seem equally capable of explaining a considerable body of psychophysical data, and it would be difficult to devise an experiment to determine which model is more nearly correct.
CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens (2017)

The proof of target engagement (TE) is a key element for evaluating potential investment in drug development. The cellular thermal shift assay (CETSA) is expected to facilitate direct measurement of intracellular TE at all stages of drug development. However, there have been no reports of applying this technology to comprehensive animal and clinical studies. This report demonstrates that CETSA can not only quantitatively evaluate the drug-TE in mouse peripheral blood, but also confirm TE in animal tissues exemplified by using the receptor interacting protein 1 kinase (RIPK1) lead compound we have developed. Our established semi-automated system allows evaluation of the structure-activity relationship using native RIPK1 in culture cell lines, and also enables estimation of drug occupancy ratio in mouse peripheral blood mononuclear cells. Moreover, optimized tissue homogenisation enables monitoring of the in vivo drug-TE in spleen and brain. Our results indicate that CETSA methodology will provide an efficient tool for preclinical and clinical drug development.
Satellite Beam Handover Strategy to Improve Return Link Resource Utilization (2011)

Digital Video Broadcasting -Return Channel Satellite (DVB-RCS) has been successively implemented. In general, multi beam satellite employs uniform allocation of RF power and bandwidth to multi beams, since it is hard to predict the distribution of traffic requests and the arrival rate of new connection. This makes it difficult to satisfy the traffic requests in a beam. Thus, when an unpredictable event, such as a disaster, regional warfare and deteriorating weather conditions, occur in a special spot beam, many more terminals will require access to a special beam channel. This causes the special beam channel to be saturated, while adjacent beam channel resources are available. Thus, we propose a novel handover strategy to improve satellite return link resource utilization using load balancing handover. Simulation results shows the proposed handover algorithm outperforms conventional handover algorithms in terms of new connection block probability, handover block probability, return link resource utilization and capacity request block rate.
Factoring with n+2 clean qubits and n-1 dirty qubits (2017)

We present reversible classical circuits for performing various arithmetic operations aided by dirty ancillae (i.e. extra qubits in an unknown state that must be restored before the circuit ends). We improve the number of clean qubits needed to factor an n-bit number with Shor's algorithm from 1.5n+O(1) to n+2, assisted by n-1 dirty qubits, without increasing the asymptotic size or depth of the circuit.
Total plasma creatinine: an accurate measure of total striated muscle mass (1981)

Creatinine is a metabolite unique to striated muscle. Measurement of 24-h urinary creatinine excretion is an established method for estimating striated muscle mass. However, accurate assessment of urinary creatinine excretion is often impractical. We investigated the hypothesis that total plasma creatinine could be used instead of urinary creatinine excretion to estimate body composition. In 24 men, plasma volume and plasma creatinine concentration were measured, and total plasma creatinine was calculated as the product of these two measurements. Other measurements included urinary creatinine excretion, total body water, and anthropometry. Total plasma creatinine correlated strongly with urinary creatinine excretion (r = 0.82) and with weight, total body water, and anthropometrically estimated lean body mass. Muscle mass could be predicted by the equation: 0.88 x total plasma creatinine (mg). To verify this relationship, total plasma creatinine was prospectively measured in four dogs, then their total striated muscle was removed and weighed. Predicted muscle mass was within +/- 3.9% (range = 0.5-10.8%) of observed muscle mass. The ability to estimate muscle mass conveniently and accurately from total plasma creatinine should prove valuable for future studies in physiology and body composition.
Dynamic base register caching (1991)

address reference degrees of spatial and temporal higher order address lines carry streams exhibit high locality, many of the redundant information. By caching the higher order portions of address references in a set of dynamically allocated base registers, it becomes possible to transmit small register indices between the processor and memory instead of the high order address bits themselves. Trace driven simulations indicate that this technique can significantly reduce processor-to-memory address bus width without an appreciable loss in performance, fhereby increasing available processor bandwidth. Our resulfs imply that as much as 25% of the available 1/0 bandwidth of a processor is used less than 1% of the time.
Mineral exploration with the AeroTEM system (2002)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2002Mineral exploration with the AeroTEM systemAuthors: S. J. BalchW. P. BoykoG. BlackR. N. PedersenS. J. BalchAeroQuest Limited, W. P. BoykoAeroQuest Limited, G. BlackAeroQuest Limited, and R. N. PedersenAeroQuest Limitedhttps://doi.org/10.1190/1.1817437 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1817437FiguresReferencesRelatedDetailsCited ByA survey of current trends in near-surface electrical and electromagnetic methodsEsben Auken, Louise Pellerin, Niels B. Christensen, and Kurt Sørensen7 September 2006 | GEOPHYSICS, Vol. 71, No. 5 SEG Technical Program Expanded Abstracts 2002ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2002 Pages: 2478 publication data© 2002 Copyright © 2002 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 03 Jan 2005 CITATION INFORMATION S. J. Balch, W. P. Boyko, G. Black, and R. N. Pedersen, (2002), "Mineral exploration with the AeroTEM system," SEG Technical Program Expanded Abstracts : 9-12. https://doi.org/10.1190/1.1817437 Plain-Language Summary PDF DownloadLoading ...
Ferrioxamine excretion in iron-loaded man (1982)

Factors affecting iron excretion after subcutaneous desferrioxamine infusion were evaluated in individuals with iron overload. Urinary iron varied directly, whereas stool iron varied inversely with the level of erythropoiesis. Ascorbic acid greatly enhanced urinary iron excretion but had a less constant effect on stool iron. Stool iron losses contributed a greater proportion of total iron excretion at higher chelator dosage. These studies indicate the importance of biliary iron excretion in monitoring the effectiveness of desferrioxamine. They also suggest that large chelator doses may remove established iron overload much more rapidly than has previously been realized.
A high-sensitivity magnetoresistive sensor (1990)

A magnetic sensor technology that addresses both higher sensitivity and lower power is described. The sensor is based on the magnetoresistive effect exhibited in a thin film of ferromagnetic material. The basics of the magnetoresistive transducer and the concept, design, fabrication, and characterization of a single-axis, thin-film magnetometer are presented. Minimum sensor noise is balanced with minimum sensor power dissipation to provide a sensor with a minimum noise of 2 mu G/ square root Hz at a power dissipation of 800 mu W. A discussion of the use of this sensor in magnetic anomaly detection applications is also included. The improvements in increased sensitivity and lower power of this magnetoresistance sensor technology open new possibilities for magnetic anomaly detection applications. The goal is to develop a system that maximizes the capability of the sensor and minimizes compromises due to background noise.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Characteristics of automated power system monitoring and management platforms (2002)

This paper considers the concept of an automated service dispatch system in the management of a DC powering infrastructure. The general characteristics of telecommunication DC power system management are discussed and a model for automated service dispatch is proposed.
Detection of animal viruses using nucleic acid sequence-based amplification (NASBA). (2006)

As seen in recent avian influenza outbreaks in Asia, prevention is the key to fighting infectious disease successfully. Efficient disease surveillance systems on the basis of molecular diagnostics will help monitor the emergence of viruses in the early stage and thus prompt containment measures can be in place to minimize disease spread. Here we describe and review molecular diagnostics focusing on nucleic acid sequence-based amplification (NASBA) technology in detecting viruses causing animal diseases, such as avian influenza, foot-and-mouth disease, and Newcastle disease. NASBA offers high sensitivity, specificity, accuracy, and speed of availability of results, and NASBA would be the most applicable molecular diagnostics for disease surveillance and control.
Transcription factor C/<scp>EBP</scp>‐β mediates downregulation of dipeptidyl‐peptidase <scp>III</scp> expression by interleukin‐6 in human glioblastoma cells (2014)

Dipeptidyl-peptidase III (DPP III) is a cytosolic metallo-aminopeptidase implicated in various physiological and pathological processes. A previous study from our laboratory indicated an elevated expression of DPP III in glioblastoma (U87MG) cells. In the present study we investigated the role of interleukin-6 (IL-6), a pleiotropic cytokine produced by glial tumors, in the regulation of DPP III expression. Immunohistochemistry, western blotting and quantitative RT-PCR were used for quantitation of DPP III and IL-6 in human glioblastoma cells and tumors. Cell transfections and DPP III promoter reporter assays were performed to study the transcriptional regulation of DPP III by IL-6. Promoter deletion analysis, site directed mutagenesis, chromatin immunoprecipitation assays and small interfering RNA (siRNA) technology was employed to elucidate the molecular mechanism of IL-6 mediated regulation of DPP III expression in glioblastoma cells. Our results for the first time demonstrate a negative correlation (r = 0.632, P = 0.01) between DPP III and IL-6 in both human tumors and cultured glioblastoma cells. Treatment of U87MG cells with IL-6 significantly decreased DPP III expression with a concomitant increase in the levels of transcription factor CCAAT/enhancer binding protein beta (C/EBP-β). Deletion/mutagenesis of C/EBP-β binding motif of DPP III promoter significantly increased its activity and abolished its responsiveness to IL-6. This effect could also be mimicked by C/EBP-β siRNA. In conclusion our study for the first time demonstrates C/EBP-β mediated transcriptional downregulation of DPP III by IL-6. Our results demonstrating a negative correlation between IL-6 and DPP III taken together with the previously reported prognostic significance of this cytokine in glioblastoma suggests that DPP III may prove useful as a prognostic marker.
Open Trial of Bupropion SR in Adolescent Major Depression (2003)

In this preliminary, small open study, depressed adolescents showed a marked response to bupropion SR.
Ecology, Inhibitory Activity, and Morphogenesis of a Marine Antagonistic Bacterium Belonging to the <i>Roseobacter</i> Clade (2005)

Roseobacter strain 27-4 has been isolated from a turbot larval rearing unit and is capable of reducing mortality in turbot egg yolk sac larvae. Here, we demonstrate that the supernatant of Roseobacter 27-4 is lethal to the larval pathogens Vibrio anguillarum and Vibrio splendidus in a buffer system and inhibited their growth in marine broth. Liquid chromatography (LC) with both UV spectral detection and high-resolution mass spectrometry (HR-MS) identified the known antibacterial compound thiotropocin or its closely related precursor tropodithietic acid in the bioactive fractions. Antibacterial activity correlated with the appearance of a brownish pigment and was only formed in marine broth under static growth conditions. A thick biofilm of multicellular star-shaped aggregated cells formed at the air-liquid interface under static growth conditions. Here, the bioactive compound was the base peak in the LC-UV chromatograms of the extracts where it constituted 15% of the total peak area. Aerated conditions results in 10-fold-higher cell yield, however, cultures were nonpigmented, did not produce antibacterial activity, and grew as single cells. Production of antibacterial compounds may be quorum regulated, and we identified the acylated homoserine lactone (3-hydroxy-decanoyl homoserine lactone) from cultures of Roseobacter 27-4 using LC-HR-MS. The signal molecule was primarily detected in stagnant cultures. Roseobacter 27-4 grew between 10 and 30 degrees C but died rapidly at 37 degrees C. Also, the antibacterial compounds was sensitive to heat and was inactivated at 37 degrees C in less than 2 days and at 25 degrees C in 8 days. Using Roseobacter 27-4 as a probiotic culture will require that is be established in stagnant or adhered conditions and, due to the temperature sensitivity of the active compound, constant production must be ensured.
Causal Relationship Between Anti-TPO IgE and Chronic Urticaria by <i>In Vitro</i> and <i>In Vivo</i> Tests (2018)

Anti-TPO IgE is not a specific biomarker for CSU. However, IgE against TPO plays a pathogenic role in inducing effector cell activation and skin exacerbation in some patients with CSU.
Image based adaptive optics through optimisation of low spatial frequencies (2007)

We present a wave front sensorless adaptive optics scheme for an incoherent imaging system. Aberration correction is performed through the optimisation of an image quality metric based upon the low spatial frequency content of the image. A sequence of images is acquired, each with a different aberration bias applied and the correction aberration is estimated from the information in this image sequence. It is shown, by representing aberrations as an expansion in Lukosz modes, that the effects of different modes can be separated. The optimisation of each mode becomes independent and can be performed as the maximization of a quadratic function, requiring only three image measurements per mode. This efficient correction scheme is demonstrated experimentally in an incoherent transmission microscope. We show that the sensitivity to different aberration magnitudes can be tuned by changing the range of spatial frequencies used in the metric.We also explain how the optimization scheme is related to other methods that use image sharpness metrics.
Comparative Crystal Chemistry of Dense Oxide Minerals (2000)

INTRODUCTION Oxygen is the most abundant element in the Earth, constituting about 43 percent by weight of the crust and mantle. While most of this mass is incorporated into silicates, the next most abundant mineral group in the planet is the oxides. The oxide minerals are generally considered to be those oxygen-based minerals that do not contain a distinct polyanionic species such as OH - , CO 3 2- , SO 4 2- PO 4 3- , SiO 4 4- , etc. The oxide structures are also of interest in mineral physics, because, at high pressure, many silicates are known to adopt structures similar to the dense oxides (see Hazen and Finger this volume). Oxide minerals, because of their compositional diversity and structural simplicity, have played a special role in the development of comparative crystal chemistry. Many of the systematic empirical relationships regarding the behavior of structures with
Geopolitics at the margins? Reconsidering genealogies of critical geopolitics (2013)

Critical geopolitics has become one of the most vibrant parts of political geography. However it remains a particularly western way of knowing which has been much less attentive to other traditions of thinking. This paper engages with Pan-Africanism, and specifically the vision of the architect of post-colonial Tanzania, Julius Nyerere, to explore this overlooked contribution to critical engagements with geopolitics. Pan-Africanism sought to forge alternative post-colonial worlds to the binary geopolitics of the Cold War and the geopolitical economy of neo-colonialism. The academic division of labour has meant that these ideas have been consigned to African studies rather than being drawn into wider debates around the definitions of key disciplinary concepts. However Nyerere's continental thinking can be seen as a form of geopolitical imagination that challenges dominant neo-realist projections, and which still has much to offer contemporary political geography.
Transcatheter Endomyocardial Laser Revascularization: A Feasibility Test (1998)

By means of a special catheter system, a total of 76 endomyocardial laser channels were percutaneously produced in a controllable manner at selected sites in 6 beating canine hearts. Acute patency of channels (length = 4-11 mm, diameter = 0.5-1.2 mm) was documented angioscopically and histologically. This minimally invasive method might be useful for revascularising certain patients with ischemic heart disease without resorting to open-chest surgery.
Protection from lethal murine graft-versus-host disease without compromise of alloengraftment using transgenic donor T cells expressing a thymidine kinase suicide gene (2001)

Donor T cells play a pivotal role in facilitating alloengraftment but also cause graft-versus-host disease (GVHD). Ex vivo T-cell depletion (TCD) of donor marrow is the most effective strategy for reducing GVHD but can compromise engraftment. This study examined an approach whereby donor T cells are selectively eliminated in vivo after transplantation using transgenic mice in which a thymidine kinase (TK) suicide gene is targeted to the T cell using a CD3 promoter/enhancer construct. Lethally irradiated B10.BR mice transplanted with major histocompatibility complex (MHC)-incompatible TCD C57BL/6 (B6) bone marrow (BM) plus TK(+) T cells were protected from GVHD after treatment with ganciclovir (GCV) in a schedule-dependent fashion. To examine the effect of GCV treatment on alloengraftment, sublethally irradiated AKR mice underwent transplantation with TCD B6 BM plus limiting numbers (5 x 10(5)) of B6 TK(+) T cells. Animals treated with GCV had comparable donor engraftment but significantly reduced GVHD when compared with untreated mice. These mice also had a significantly increased number of donor splenic T cells when assessed 4 weeks after bone marrow transplantation. Thus, the administration of GCV did not render recipients T-cell deficient, but rather enhanced lymphocyte recovery. Adoptive transfer of spleen cells from GCV-treated chimeric mice into secondary AKR recipients failed to cause GVHD indicating that donor T cells were tolerant of recipient alloantigens. These studies demonstrate that administration of TK gene-modified donor T cells can be used as an approach to mitigate GVHD without compromising alloengraftment.