gebhart/patrepeval huggingface dataset:
Kinetics of gaseous fluorine reactions (1974)

The review covers the literature on gaseous fluorine kinetics through 1973, with some references from 1974. Although the chemical reactions important in hydrogen fluoride lasers are briefly considered, no attempt has been made to review the energy-transfer processes or technology important in such systems. Discussions of flames, electric discharges and the reactions of nuclear-recoil 18F atoms have only been included when these have provided data on the kinetics or mechanisms of thermal fluorine reactions.
Thalidomide in the Treatment of Plasma Cell Malignancies (2001)

Article Tools EDITORIAL Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2001.19.16.3593 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11504740 Thalidomide in the Treatment of Plasma Cell Malignancies S. Vincent RajkumarxS. Vincent RajkumarSearch for articles by this author , Robert A. KylexRobert A. KyleSearch for articles by this author Show More Mayo Clinic and Mayo Foundation, Rochester, MN https://doi.org/10.1200/JCO.2001.19.16.3593 First Page Full Text PDF Figures and Tables © 2001 by American Society of Clinical Oncology
Extracardiac Ablation of the Canine Atrioventricular Junction by Use of High-Intensity Focused Ultrasound (1999)

High-intensity focused ultrasound produces well-demarcated lesions and appears to be a feasible energy source to create complete AV block within the beating heart without damaging the overlying or underlying cardiac tissue. This energy source may allow for a noninvasive approach to ablation of cardiac arrhythmias.
Sensing of multiple unrelated tire parameters using electrically open circuit sensors having no electrical connections (2009)

All sensors or sensor systems previously used for tire measurements have one common feature - the sensors are part of electrically closed circuits and electrical connections are used to form the closed circuits. In this paper, we present a new tire safety monitoring system using a recently developed method for designing, powering and interrogating sensors developed at NASA. In lieu of sensors being a collection of components assembled using electrical connections, the sensors are patterns of electrically conductive material that can store electric fields and magnetic fields without electrical connections. They are powered using oscillating magnetic fields and respond with their own magnetic fields whose signatures give information about the measured parameters. Because no electrical connections are used to power, communicate with the sensor or to make the sensor, there is no point on the sensor that if damaged, renders the sensor non-functional. Many damage events simply shift the sensor's frequency range. Survivability of the sensor allows it to continue measurement while damaged. The physical quantities to be measured are correlated to the sensor's magnetic field response amplitude, frequency and bandwidth. The proposed method measures wheel speed, rotation angle, direction, acceleration, temperature, damage and wear of tread element by using two or more sensors. In this study, two sensors are used. One of the sensors is coated with temperature sensitive dielectric material. The two sensors working cooperatively are able to measure the seven parameters. The results and multifunctional measurement strategies are presented.
Antimicrobial photodynamic therapy: An overview (2011)

Inflammatory periodontal disease caused by dental plaque is characterized by the clinical signs of inflammation and loss of periodontal tissue support. The mechanical removal of this biofilm and adjunctive use of antibacterial disinfectants and antibiotics have been the conventional methods of periodontal therapy. But the removal of plaque and the reduction in the number of infectious organisms can be impaired in sites with difficult access. The possibility of development of resistance to antibiotics by the target organism has led to the development of a new antimicrobial concept with fewer complications. Photodynamic therapy (PDT) involves the use of low power lasers with appropriate wavelength to kill micro organisms treated with a photosensitizer drug. PDT could be a useful adjunct to mechanical as well as antibiotics in eliminating periopathogenic bacteria.
Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model (2010)

Preeclampsia is a relatively common pregnancy-related disorder. Both maternal and fetal lives will be endangered if it proceeds unabated. Recently, the placenta-derived anti-angiogenic factors, such as soluble fms-like tyrosine kinase-1 (sFLT1) and soluble endoglin (sENG), have attracted attention in the progression of preeclampsia. Here, we established a unique experimental model to test the role of sFLT1 in preeclampsia using a lentiviral vector-mediated placenta-specific expression system. The model mice showed hypertension and proteinuria during pregnancy, and the symptoms regressed after parturition. Intrauterine growth restriction was also observed. We further showed that pravastatin induced the VEGF-like angiogenic factor placental growth factor (PGF) and ameliorated the symptoms. We conclude that our experimental preeclamptic murine model phenocopies the human case, and the model identifies low-dose statins and PGF as candidates for preeclampsia treatment.
Antiplatelet antibody [7E3 F(ab')2] prevents rethrombosis after recombinant tissue-type plasminogen activator-induced coronary artery thrombolysis in a canine model. (1990)

Coronary artery rethrombosis can complicate initially effective thrombolytic therapy. Platelets interacting with injured vascular endothelium in a region along the coronary artery with reduced luminal cross-sectional area contribute to rethrombosis. The purpose of this study was to investigate the potential of the F(ab')2 fragment of the murine monoclonal antibody 7E3 [7E3 F(ab')2] to prevent rethrombosis after intracoronary clot lysis with recombinant tissue-type plasminogen activator (rt-PA) in an experimental model. The 7E3 F(ab')2 binds to the platelet glycoprotein IIb/IIIa complex (GPIIb/IIIa), thereby preventing platelet-fibrinogen interaction and intravascular thrombus formation. Experimental coronary artery thrombosis was produced in the anesthetized dog by application of direct anodal current to the intimal surface of the left circumflex coronary artery in the region of an external stenosis. Lysis of the established intracoronary thrombus was achieved with the intravenous administration of rt-PA (25 mg) after which the animals were randomized into two groups. Group 1 (n = 10) served as the control, receiving the saline diluent, and group 2 (n = 9) received 7E3 F(ab')2, given as a single intravenous injection (0.8 mg/kg). The times required for occlusive thrombus formation, rt-PA-induced thrombolysis, and rethrombosis (if it occurred) were similar in the animals treated with saline and those treated with 7E3 F(ab')2. The initial left circumflex coronary artery blood flow was similar in both groups but decreased to a negligible level in group 1. In group 2, left circumflex coronary artery blood flow declined modestly (24 +/- 2 to 10 +/- 2 ml/min). Rethrombosis occurred in all animals in group 1 but in only two of nine animals in group 2 (p less than 0.05). Oscillations in coronary blood flow preceded rethrombosis in group 1, whereas 7E3 F(ab')2 stabilized left circumflex coronary artery blood flow patterns during the course of teh experimental protocol (5.2 +/- 0.9 vs. 0.7 +/- 0.4 oscillations, respectively; p less than 0.05). Thrombus mass recovered from the left circumflex coronary artery at the conclusion of each experiment was greater in group 1 as compared with group 2 (7.0 +/- 2.3 vs. 1.5 +/- 0.7 mg, respectively; p less than 0.05). The area of left ventricle at risk for infarction was similar in both groups but infarct size, infarction/at risk assessed histochemically, was larger in group 1 than group 2 (35 +/- 9% vs. 6 +/- 4%, respectively; p less than 0.05). Platelet aggregation induced by ADP and arachidonic acid was similar at baseline for all of the animals.(ABSTRACT TRUNCATED AT 400 WORDS)
Editorial (2019)

Conference of the Jean Monnet Project INTEROP -"EU Digital Single Market as a political calling: interoperability as the way forward", took place at the noble Auditorium of the Law School of the University of Minho.The twodays Conference received the inputs of several national and international scholars, in Portuguese language, in order to address main INTEROP aims and goals in a proximity perspective and giving space to young researchers -Master's and PhD students -to take part on the project's results.During the Conference there was a Round Table for Young Researchers, selected through an analysis, made by a Key Staff Member of the Project -Professor Joana Covelo de Abreu -, of a call for abstracts.One of the papers produced to that Round Table was submitted through the blind peer review process of UNIO and was published in this number.This issue of UNIO -EU Law Journal addresses final conference inputs and also acknowledges young researchers' initiative concerning INTEROP scope of action and tries to take it Digital Single Market concerns and expectations further, preparing the aftermath of that Jean Monnet Project.Furthermore, and since it is not a special issue, it also has a text that, despite being influenced by digital matters (namely access to administrative documents), addresses topics outside INTEROP aims but it has revealed itself as actual and needed to the discussion of EU law matters and was introduced in this volume.The interaction with scholars, stakeholders, policy makers, civil servants and judicial operators can be perceived through this issue.We open this edition of UNIO with a paper by Piedade Costa de Oliveira, Member of the Legal Service of the European Commission, addressing the topic of electronic commerce and collaborative economy in the light of a Digital Single Market.With this contribution, the author intends to outline how the EU is regulating collaborative economy, taking as referral the e-Commerce Directive, the ECJ's digressive jurisprudence and the Commission's pragmatic approach on the matter.We continue this issue with a contribution by Caterina Fratea, Professor at the Department of Law of the University of Verona, where the author links electronic commerce and fashion industry in order to raise the curtain on which are the challenges posed to competition law before an established Digital Single Market.Particularly, the author aims at assessing how online sales affect market strategies and competition law, focusing on selective distribution agreements.For that purpose, the paper deals with ECJ's jurisprudence and how it revealed that certain contractual
Chaotic signals and systems for communications (1993)

The authors propose and demonstrate two approaches to communications based on synchronized chaotic signals and systems. In the first approach, a chaotic masking signal is added at the transmitter and regenerated and subtracted at the receiver. The second approach utilizes modulation of the coefficients of the chaotic system in the transmitter and corresponding detection of synchronization error in the receiver to transmit binary-valued bit streams. Both approaches are demonstrated using a transmitter circuit with dynamics that are governed by the chaotic Lorenz system. A synchronizing receiver circuit which exploits the ideas of synchronized chaotic systems is used for signal recovery.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Estimation of depth on thick edges from sharp and blurred images (2003)

This article deals with the generalization of a local depth estimation method using sharp edges and blurred edges. This Depth from Defocus method is explained and the theoretical relations are defined. Improvements concerning the generalization and the noise sensitivity on the depth estimation are developed and application conditions are exposed. Some results on synthetic images are presented to illustrate the method efficiency.
High Salt Lysates: a Simple Method to Store Blood Samples Without Refrigeration for Subsequent Use with DNA Probes (1988)

Blood specimens to be tested for the presence of Plasmodium falciparum using specific DNA probes can be stored as high salt lysates (HSL) without refrigeration. The lysates are prepared from 100 µl blood samples by a simple 3-step procedure using 2 volumes of H2O to lyse the erythrocytes (step I), 1 volume of a detergent/EDTA mix to lyse the parasites (step II), followed by the addition of 1 volume cesium trifluoroacetate (CsTFA) (step III). The parasite DNA was found to be undegraded, as shown by the unaltered pattern of repetitive sequences obtained after storage of up to 1 month at 37°C, due to the inhibition of DNA degrading enzymes by the cesium salt. The bulk of protein can be removed from the samples by a 1-step precipitation. The addition of 0.3 volumes of a mixture of ethanol: chloroform: isoamyl alcohol (2.5:1:0.04 v/v) precipitates >90% of the proteins from the lysates, leaving >86% of the parasite DNA in the supernatant. The reduced protein content of the samples, when applied to solid supports, results in an increased signal: background ratio on autoradiograms.
The Advanced Low-Emissions Catalytic-Combustor Program: Phase I — Description and Status (1979)

The Advanced Low-Emissions Catalytic-Combustor Program ia an ongoing three-phase contract contract effort with the primary objective of evolving the technology required for incorporating catalytic combustors into advanced aircraft gas-turbine engines. Phase I is corrently in progress. At the present time, analytical evaluation is being conducted on advanced catalytic combustor concepts — including variable geometry — with their known inherent potential advantages of low level pollutant emission, widened combustion at ability limits, and reduced pattern factor for longer turbine life. Phases II and III will consist of experimental evaluation of the most promising concepts.
Preparation of Colloidal Gold Probes (1998)

As long ago as 1857 (1), Michael Faraday in an address to the Royal Society recognized the reactive properties of colloidal metal particles (in particular gold) with light. Since 1933 (2), a range of methods have been devised for producing gold sols. It was not until 1971, however, that Faulk and Taylor (3) published a method for binding proteins to gold particles for use in lmmunocytochemistry at the electron microscope level. Nowadays, colloidal gold is incorporated into probes that are widely used in the biological sciences both for light and electron microscopy.
Lyme disease: the cause, diagnosis, and treatment. (1995)

Further study is needed to develop an accurate test for Lyme disease.
Introduction (2005)

Fluent aphasia is an interesting condition for various reasons. For a number of years, the existence of two types of aphasia that not only sound different but arise from different loci of cerebral damage has been used to support the notion of two independent domains of language, the grammar and the lexicon. Damage to cerebral tissue in the pre-Rolandic areas of the cortex is associated with damage to the grammar or to the computational aspects of language, while the mental lexicon, our vocabulary store, is spared. In fact it is not clear whether aphasia causes loss or damaged access to this domain of language, as we will discuss below. In contrast to this state, damage to the post-Rolandic area results in damage to the mental lexicon or access to that lexicon: the grammar, or access to the computational aspects of language, is assumed to be spared. So, these two pathological conditions that we will refer to as non-fluent and fluent aphasia, epitomise damaged grammar versus damaged lexis. To take idealised cases, non-fluent speakers exhibit grammatical errors whereas fluent aphasic speakers struggle with lexical recall. Of course, this can be seen as a gross over-simplification and we will examine the flaws in this description as we progress through the monograph, but it not only provides a good starting point but also encapsulates issues that will be explored.
X-ray Structure Analysis of Indazolium<i>trans-</i>[Tetrachlorobis(1<i>H</i>-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism (2016)

Ruthenium(III) complexes are promising candidates for anticancer drugs, especially the clinically studied indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) and its analogue sodium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (NKP-1339). Several studies have emphasized the likely role of human serum proteins in the transportation and accumulation of ruthenium(III) complexes in tumors. Therefore, the interaction between KP1019 and human serum albumin was investigated by means of X-ray crystallography and inductively coupled plasma mass spectrometry (ICP-MS). The structural data unambiguously reveal the binding of two ruthenium atoms to histidine residues 146 and 242, which are both located within well-known hydrophobic binding pockets of albumin. The ruthenium centers are octahedrally coordinated by solvent molecules revealing the dissociation of both indazole ligands from the ruthenium-based drug. However, a binding mechanism is proposed indicating the importance of the indazole ligands for binding site recognition and thus their indispensable role for the binding of KP1019.
Differential determination of phospholipase A2 and PAF-acetylhydrolase in biological fluids using fluorescent substrates (1999)

The purpose of the present study was the development and evaluation of a fluorimetric method for the screening and differential determination of phospholipase A(2) and PAF-acetylhydrolase in bronchoalveolar lavage (BAL) fluid and serum. Phospholipase A(2) was determined using C(12)-NBD-PC in the presence of Ca(2+), from the slope of the fluorescence enhancement due to the formation of C(12)-NBD-fatty acid. PAF-acetylhydrolase was determined using C(6)-NBD-PC, from the slope of the curve due to C(6)-NBD-fatty acid formation in the absence of Ca(2+). The results were confirmed after TLC analysis. The method's selectivity was evaluated by comparing to radiometric measurements. Light scattering did not interfere and inner filter effects was not observed under our experimental conditions. The effects of pH, temperature, and Ca(2+) were investigated. Protein caused an increase in the background fluorescence of both NBD-PCs. The standard curves of both NBD-fatty acids exhibited the same slope. Linearity extended at least up to 4. 5 nmoles per ml of reaction mixture at the normal pH 7.4. The fluorescence of the NBD-fatty acids remained stable for increasing concentrations of BAL fluid and serum and for BSA up to 100 microg/ml of reaction mixture. Porcine pancreatic PLase A(2) showed preference for C(12)-NBD-PC in the presence of Ca(2+), while without Ca(2+), serum PAF-AcH hydrolyzed only C(6)-NBD-PC. The method is highly sensitive, accurate, and reproducible and can be applied for the differential determination of phospholipase A(2) and PAF-acetylhydrolase activities in BAL fluid and serum.
Syntheses and Facile Cleavage of Five-Membered Ring Sultams<sup>1</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses and Facile Cleavage of Five-Membered Ring Sultams1WILLIAM F. ERMAN and HERBERT C. KRETSCHMARCite this: J. Org. Chem. 1961, 26, 12, 4841–4850Publication Date (Print):December 1, 1961Publication History Published online1 May 2002Published inissue 1 December 1961https://doi.org/10.1021/jo01070a015RIGHTS & PERMISSIONSArticle Views822Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Control of polymorphism by ‘tailor‐made’ polymeric crystallization auxiliaries. Preferential precipitation of a metastable polar form for second harmonic generation (1990)

Polar crystals can display pyroelectricity, piezoelectricity and frequency doubling leading to second harmonic generation. These metastable polar polymorphs can be selectively precipitated to the exclusion of stable, non‐polar forms by the use of polymeric crystallization auxiliaries. The approach is based on the hypothesis that crystal nuclei assume structures very similar to those of the crystals into which they develop.
Topical applications of caffeine or (−)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice (2002)

SKH-1 hairless mice were irradiated with ultraviolet B (UVB) twice weekly for 20 weeks. These tumor-free mice, which had a high risk of developing skin tumors during the next several months, were then treated topically with caffeine (6.2 micromol) or (-)-epigallocatechin gallate (EGCG; 6.5 micromol) once a day 5 days a week for 18 weeks in the absence of further treatment with UVB. Topical applications of caffeine to these mice decreased the number of nonmalignant and malignant skin tumors per mouse by 44% and 72%, respectively. Topical applications of EGCG decreased the number of nonmalignant and malignant tumors per mouse by 55% and 66%, respectively. Immunohistochemical analysis showed that topical applications of caffeine or EGCG increased apoptosis as measured by the number of caspase 3-positive cells in nonmalignant skin tumors by 87% or 72%, respectively, and in squamous cell carcinomas by 92% or 56%, respectively, but there was no effect on apoptosis in nontumor areas of the epidermis. Topical applications of caffeine or EGCG had a small inhibitory effect on proliferation in nonmalignant tumors as measured by BrdUrd labeling (16-22%), and there was also a similar, but nonsignificant, inhibitory effect on proliferation in malignant tumors. The results suggest a need for further studies to determine whether topical applications of caffeine or EGCG can inhibit sunlight-induced skin cancer in humans.
Regulation of Cocaine Reward by CREB (1998)

Cocaine regulates the transcription factor CREB (adenosine 3', 5'-monophosphate response element binding protein) in rat nucleus accumbens, a brain region that is important for addiction. Overexpression of CREB in this region decreases the rewarding effects of cocaine and makes low doses of the drug aversive. Conversely, overexpression of a dominant-negative mutant CREB increases the rewarding effects of cocaine. Altered transcription of dynorphin likely contributes to these effects: Its expression is increased by overexpression of CREB and decreased by overexpression of mutant CREB. Moreover, blockade of kappa opioid receptors (on which dynorphin acts) antagonizes the negative effect of CREB on cocaine reward. These results identify an intracellular cascade-culminating in gene expression-through which exposure to cocaine modifies subsequent responsiveness to the drug.