gebhart/patrepeval huggingface dataset:
<b> <i>In Vivo</i> </b> Targeting of Underglycosylated MUC-1 Tumor Antigen Using a Multimodal Imaging Probe (2004)

One of the most difficult challenges of oncology is to improve methods for early tumor detection, which is crucial for the success of cancer therapy and greatly improves the survival rate. Underglycosylated mucin-1 antigen (uMUC-1) is one of the early hallmarks of tumorigenesis and is overexpressed and underglycosylated on almost all human epithelial cell adenocarcinomas as well as in nonepithelial cancer cell lines, as well as in hematological malignancies such as multiple myeloma, and some B-cell non-Hodgkin lymphomas. In this study, we designed, synthesized, and tested a novel multimodal imaging probe specifically recognizing in vivo uMUC-1 antigen in an animal model of human cancer. Furthermore, in vivo magnetic resonance- and near-infrared-imaging experiments on tumor-bearing animals showed specific accumulation of the probe in uMUC-1-positive tumors and virtually no signal in control tumors. We expect that this probe has a potential to greatly aid in screening prospective patients for early cancer detection and in monitoring the efficacy of drug therapy.
Preparation of Silicon Carbide Fiber from Activated Carbon Fiber and Gaseous Silicon Monoxide (1994)

Crystalline silicon carbide (SiC) fiber was produced by a new, simple procedure. Activated carbon fiber (ACF) was reacted with gaseous silicon monoxide and was converted to SiC fiber at elevated temperature and reduced pressure. The reaction was completed at temperatures as low as 1473 K. The reacted fiber consisted of submicrometer particles which were not observed in the original ACF. The SiC crystal size in the reacted fiber was approximately 30 nm. The microstructure of the fiber became dense after it was heat‐treated in air at 1573 K or in nitrogen gas at 1873 K.
Pacemaker-Mediated Tachycardia: Manufacturer Specifics and Spectrum of Cases (2015)

Pacemaker-mediated tachycardia (PMT) is the term used to describe a repetitive sequence of sensed retrograde P waves followed by ventricular pacing at or below the maximum tracking rate. The following events can promote atrioventricular (AV) dissociation, retrograde conduction, and the onset of PMT: ventricular or atrial extrasystole, an excessively long programmed AV delay, external interference or myopotentials sensed by the atrial channel, atrial sensing or pacing failure, the absence of postventricular atrial refractory period extension after removal of a magnet, and VDD pacing at a higher rate than sinus rate. In contemporary devices, each manufacturer has a proprietary algorithm to detect and terminate PMT. Because of the increase in the number and complexity of the pacing algorithms and because of manufacturer-driven differences, a basic understanding of these new algorithms is important for patient care. We review here the main elements of the physiopathology of this type of tachycardia, describe the specific characteristics of the different manufacturers, and present representative clinical cases.
Realtime Control of Multiple-focus Phased Array Heating Patterns Based on Noninvasive Ultrasound Thermography (2011)

A system for the realtime generation and control of multiple-focus ultrasound phased-array heating patterns is presented. The system employs a 1-MHz, 64-element array and driving electronics capable of fine spatial and temporal control of the heating pattern. The driver is integrated with a realtime 2-D temperature imaging system implemented on a commercial scanner. The coordinates of the temperature control points are defined on B-mode guidance images from the scanner, together with the temperature set points and controller parameters. The temperature at each point is controlled by an independent proportional, integral, and derivative controller that determines the focal intensity at that point. Optimal multiple-focus synthesis is applied to generate the desired heating pattern at the control points. The controller dynamically reallocates the power available among the foci from the shared power supply upon reaching the desired temperature at each control point. Furthermore, anti-windup compensation is implemented at each control point to improve the system dynamics. In vitro experiments in tissue-mimicking phantom demonstrate the robustness of the controllers for short (2-5 s) and longer multiple-focus high-intensity focused ultrasound exposures. Thermocouple measurements in the vicinity of the control points confirm the dynamics of the temperature variations obtained through noninvasive feedback.
New Electrorelease Systems Based on Microporous Membranes (1990)

Electrorelease systems have previously been based on electrochemical release of molecules chemically entrapped in polymer membranes. A new type of electrorelease system is described; this system is based on a microporous membrane covered with a barrier layer which seals the pores. Electrorelease occurs upon electrochemical dissolution or disruption of the barrier layer, which opens the pores. Two different barrier layers are investigated: silver and Na+‐form Nafion. The electrorelease rate can be controlled by partially removing the barrier layer or by dividing the barrier layer into several individually addressable zones. This configuration may also be used as a multidose device.
A 100-MHz 100-dB operational amplifier with multipath nested Miller compensation structure (1992)

A 100-MHz bipolar operational amplifier has a gain of 100 dB. The op amp owes its high unity-gain bandwidth and high gain to an all-n-p-n signal path and multipath nested Miller compensation (MNMC). The phase margin with a 100-pF load is 40 degrees at 100 MHz and the amplifier settles in 60 ns to 0.1% on a 1-V step. For comparison, a similar op amp without the multipath technique has been realized. The unity-gain bandwidth of this nested Miller compensation (NMC) op amp is 60 MHz and the settling time is 70 ns. Theory and measurements confirm that the multipath technique almost doubles the bandwidth of nested Miller compensated amplifiers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Severe falciparum malaria (2000)

Journal Article Severe falciparum malaria Get access World Health Organization World Health Organization Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 94, Issue Supplement_1, April 2000, Pages 1–90, https://doi.org/10.1016/S0035-9203(00)90300-6 Published: 01 April 2000
RGD-Substituted High Molecular Weight Hyper-Branched Polyglycerols (HPG) Are Effective Platelet Inhibitors. (2007)

Abstract Peptides containing Arg-Gly-Asp (RGD) sequences are known to bind to integrins which mediate cell adhesion and therefore have been utilized in applications such as antithrombotics and tissue engineering. Although RGD and related peptides show promise, their unfavourable pharmacokinetic profiles and susceptibility to in vivo proteolysis hinder their clinical usefulness. Peptide-polymer conjugates can address one of these challenges by extending the peptide’s residence in plasma. Hyperbranched polyglycerols (HPGs) are biocompatible polyether polyols with very long plasma circulation half-lives (t1/2 ∼ 60h) and as such are ideally suited to be carriers in such conjugates. HPGs of three different molecular weights were conjugated with RGD peptides at various substitution levels. Some of the terminal hydroxyl groups of polyglycerols were converted to vinyl sulfone groups which were subsequently utilized to couple cysteine terminated RGD peptides. The following conjugates were made: 515 kDa with substitution levels of 100:1, 500:1 and 1000:1; 100 kDa with substitution levels of 100:1 and 1000:1; and 3 kDa with substitution levels of 1:1, and 10:1. RGD-coupled HPG inhibited fibrinogen binding to platelet glycoprotein IIb-IIIa as detected by flow cytometry using anti-fibrinogen. Compared to free RGD (Ic50 = 5 x 10-5 M), inhibition of fibrinogen binding increased with increasing HPG molecular weight and increasing RGD-substitution for the high MW conjugates: Ic50 for the 515 kDa conjugates were 6.3 x 10−8 M for the 100:1 substitution, 4.7 x 10-8 M for the 500:1 substitution, and 4.1 x 10−8 M for 1000:1 substitution; Ic50 for the 100 kDa conjugates were 7.0 x 10−7 M for the 100:1 substitution and 1.2 x 10−7 M for the 1000:1 substitution. Ic50 for the 3 kDa conjugates were 2 x 10−5 M for the 1:1 substitution, 2 x 10−4 M for 10:1 substitution. Similarly, platelet function, as demonstrated by MnCl2-initated aggregation was inhibited in a dose- and molecular weight-dependent manner by HPG-RGD conjugates. Platelet aggregate formation and aggregate size were confirmed by microscopy. However, unsubstituted HPG had no effect on platelet fibrinogen binding and neither conjugated nor unconjugated HPG increased platelet CD62 surface expression. Trypsin digestion (but not SBTI-treated trypsin) removed the inhibitory activity of the conjugates and thus confirmed that both fibrinogen binding and aggregation-inhibition were dependent on the RGD peptide sequence. Such multi-determinant peptide-HPG conjugates represent a new approach to the development of antithrombotic drugs.
Plasminogen activator secretion of human tumors in short-term organ culture, including a comparison of primary and metastatic colon tumors. (1983)

The secretion of plasminogen activator by explants of 92 human malignant tumors was studied in short-term organ culture. Where possible, adjacent normal tissue of the presumed origin of the tumors was also studied. The study included adenocarcinomas of the lung, colon, prostate, breast, and stomach and different types of sarcomas. In addition to the measurement of secretion rates, all tissues were quantitatively extracted to determine the amount of cell-bound enzyme. Both culture fluids and extracts were analyzed with respect to the type of plasminogen activator they contained by immunoinhibition with goat immunoglobulin G formed against purified human urinary urokinase sodium dodecyl sulfate:gel electrophoresis followed by zymography. The study yielded the following conclusions: (a) the measurement of plasminogen activator secretion rates gives a much sharper differentiation between malignant and normal tissues than does the amount of extractable enzyme; (b) the enzymes secreted in short-term organ culture are, in the great majority of the cases studied, of the urokinase type, even when a large fraction of the activator contained in the tissue is of the vascular type; (c) the secretion rates of metastatic tumors of the colon are much lower than those of the primary ones; (d) immunoperoxidase staining of tissue sections reveals that urokinase is localized predominantly in the tumor cells. The low secretion rates of metastatic tumors, probably a reflection of this property in the original cell that gave rise to the metastatic focus, could be of advantage to circulating cancer cells. Such cells would not dissolve the microthrombus thought to be essential for the arrest of cancer cells in the capillaries of target organs.
Low cost HDI multilayers – the power mesh architecture (2001)

This paper describes the power mesh architecture (PMA), a new interconnection topology which leverages the production technologies of microvias, via‐in‐pads and fine‐line lithography to allow planar power distribution and dense signal interconnection, on only two or four metal layers. The PMA was derived from the interconnected mesh power system (IMPS) developed and patented by the High Density Electronics Center (HiDEC) of the University of Arkansas. The IMPS topology was created to reduce the cost and metal layers on thin‐film and ceramic multichip modules. Power distribution characteristics of IMPS are presented as measured from various test vehicles. The PMA for PCBs is presented as well as impedance tables. The initial application of PMA is shown as well as an application that helps develop the wiring density model for PMA. Finally, the eight step design process is outlined to create a PMA board and an example of a notebook computer.
Effect of cyclodextrins and undigested starch on the loss of chenodeoxycholate in the faeces (1994)

Starch that escapes digestion in the small intestine increases the elimination of chenodeoxycholate and its metabolites in the faeces of both mice and hamsters. In contrast, the elimination of cholate and its metabolites is not increased. In vitro, the affinity of starch for chenodeoxycholate is about 90-fold greater than for cholate. beta-Cyclodextrin, which approximates to one turn of the helical structures formed by the 1,4-linked glucose units of starch, shares these properties. It is proposed that these helical structures in starch act as binding sites for bile salts.
Combined prospective and retrospective motion correction to relax navigator requirements (2011)

Prospective motion correction can prevent motion artifacts in magnetic resonance imaging of the brain. However, for high-resolution imaging, the technique relies on precise tracking of head motion. This precision is often limited by tracking noise, which leads to residual errors in the prospectively-corrected k-space data and artifacts in the image. This work shows that it is possible to estimate these tracking errors, and hence the true k-space sample locations, by applying a two-sided filter to the tracking data after imaging. A conjugate gradient reconstruction is compared to gridding as a means of using this information to retrospectively correct for the effects of the residual errors.
Site-specific introduction of functional groups into phosphodiester oligodeoxynucleotides and their thermal stability and nuclease- resistance properties (1997)

We report here the site-specific introduction of functional groups into phosphodiester oligodeoxynucleotides (ODNs). ODNs containing both 5-( N-aminohexyl)-carbamoyl-2'-deoxyuridine (H), which serves as a tether for the further conjugation of functional groups, and 5-(N,N-dimethylaminohexyl)carbamoyl-2'-deoxyuridine (D), which contributes to the thermal stability of the duplex and to the resistance to nucleolytic hydrolysis by nucleases, were synthesized. Functional groups such as folic acid and palmitic acid were site-specifically introduced into the terminus of the aminohexyl-linker of H. The thermal stability and resistance toward nuclease digestion of the modified ODNs were studied. We found that ODNs containing D and H formed stable duplexes with both the complementary DNA and RNA strands even when a bulky functional group such as folic acid, palmitic acid or cholesterol was attached to the terminus of the amino-linker. We also found that ODN analogues which contained D were more resistant to nucleolytic degradation by exo- and endonuclease than the unmodified ODN. Furthermore, duplexes formed by ODNs containing D and the complementary RNA could elicit RNase H activity.
Macrocyclic polyaminocarboxylate complexes of lanthanides as magnetic resonance imaging contrast agents (1993)

Abstract
Polymer Gels and Networks (2001)

Process and formation gels: casacade formalism applied to the network formation in organic/inorganic hybrid gel films thermoreversible and irreversible physical gels from biopolymers reversable (physical) gelation in the solutions of associating polyelectrolytes association in polyelectrolyte-catanionic vesicle systems - from phase behaviour to microstructure metal nanoparticle formation in polyelectrolyte gels with regular microstructures. Structure and behaviours of gels: structure and properties of polyampholyte gels polyelectrolyte/ionomer behaviour of polymer gels electrical behaviours and mechanical responses of polyelectrolyte gels synchrotron X-ray study on nanostructures of polyelectrolyte gel/surfactant complexes structural and dynamic behaviour of polymer gels as eludicated by NMR spectroscopy electric and magnetic field sensitive smart polymer gels rhythmically pulsating gels based on chemomechanical feedback instability.
Advances in Chemistry Series as a Publication Outlet for Divisions. (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdvances in Chemistry Series as a Publication Outlet for Divisions.Robert F. GouldCite this: J. Chem. Doc. 1963, 3, 2, 76–77Publication Date (Print):April 1, 1963Publication History Published online1 May 2002Published inissue 1 April 1963https://pubs.acs.org/doi/10.1021/c160009a008https://doi.org/10.1021/c160009a008research-articleACS PublicationsRequest reuse permissionsArticle Views29Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
&lt;title&gt;Amplitude-independent chaotic synchronization and communication&lt;/title&gt; (1995)

One problem with using chaotic synchronization to communicate is that the response system is nonlinear, so that any variation in the amplitude of the chaotic driving signal degrades synchronization of the response system to the drive system. In this work it is shown that it is possible to design a response system that reproduces a scaled version of the chaotic driving signal when the drive signal is attenuated or amplified. A simple communications system is demonstrated to show that this type of synchronization is useful, and the effects of noise on the communications system are studied.
At least 12 genotypes of hepatitis C virus predicted by sequence analysis of the putative E1 gene of isolates collected worldwide. (1993)

In a previous study we sequenced the 5' noncoding (NC) region of 44 isolates of hepatitis C virus (HCV) and identified heterogeneous domains that provided evidence for additional genetic groups of HCV not previously recognized. In this study we have determined the complete nucleotide sequence of the putative envelope 1 (E1) gene in 51 HCV isolates from around the world and found that they could be grouped into at least 12 distinct genotypes. The E1 gene sequence of 8 of these genotypes has not been reported previously. Although the genetic relatedness of HCV isolates determined by the previous analysis of the 5' NC region predicted the relationships observed in the E1 gene, analysis of the 5' NC sequence alone did not accurately predict all HCV genotypes. The nucleotide and amino acid sequence identities of the E1 gene among HCV isolates of the same genotype were in the range of 88.0-99.1% and 89.1-98.4%, respectively, whereas those of HCV isolates of different genotypes were in the range of 53.5-78.6% and 49.0-82.8%, respectively. The latter differences are similar to those found when comparing the envelope gene sequences of the various serotypes of the related flaviviruses as well as other RNA viruses. We found that some genotypes of HCV were widely distributed around the world, whereas others were identified only in discreet geographical regions. Four genotypes were identified exclusively in Africa and comprised the majority of HCV isolates on that continent. The E1 gene was exactly 576 nucleotides in length in all 51 HCV isolates with no in-frame stop codons. Analysis of the predicted E1 protein identified several conserved domains that may be important for maintaining its biological function: (i) eight invariant cysteine residues, (ii) three potential N-linked glycosylation sites, (iii) a domain of nine amino acids (GHRMAWDMM), and (iv) an amino acid doublet (GV) near the putative cleavage site at the C terminus of the protein. In conclusion, the discovery of at least 12 genotypes of HCV has important implications for HCV diagnosis and vaccine development.
Compressive Coded Aperture Video Reconstruction (2008)

Publication in the conference proceedings of EUSIPCO, Lausanne, Switzerland, 2008
TreePredict (2001)

In this paper we describe how an improved word prediction implemented on a PDA can make it easier for users to enter text. The resulting predictions are a result of trigrams using POS-tags (Part Of Speech). The first two parts of the trigrams are POS-tagged, and the last part is extended into a ternary tree, using information from the trigrams to narrow the search. With an improved predictions system, the users are more likely to trust the system, find it improves their ability to enter text with less keystrokes. It is also likely that they will to use the prediction feature more actively when they perceive that it is useful to them.
Automatic nasal continuous positive airway pressure titration in the laboratory: patient outcomes (1997)

The substitution of automatic NCPAP titration for manual titration during the first night of NCPAP in patients with OSA does not reduce the number accepting the treatment at six weeks and may slightly improve it. This has important cost saving potential.
A simple view of the Dempster-Shafer theory of evidence and its implication for the rule of combination (1986)

During the past two years, the Dempster-Shafer theory of evidence has attracted considerable attention within the AI community as a promising method of dealing with uncertainty in expert systems. As presented in the literature, the theory is hard to master. In a simple approach that is outlined in this paper, the Dempster-Shafer theory is viewed in the context of relational databases as the application of familiar retrieval techniques to second-order relations in first normal form. The relational viewpoint clarifies some of the controversial issues in the Dempster-Shafer theory and facilities its use in AI-oriented applications.
Intelligent peripheral modules for microcontrollers (2002)

The modular concept of microcontroller design provides the means whereby each module can have it's own local microengine or state machine. The main CPU communicates with the modules through dual access memory, issuing commands to semi-intelligent state machines or writing directly to registers in the module. Once a module has been given a command sequence, the peripheral can act autonomously from the CPU. With several modules working at the same time, the effect of running multiple instructions per clock cycle can be obtained. In other words, a timer module can be performing some task while the CPU is executing an unrelated algorithm.
Ag‐Functionalized Carbon Molecular‐Sieve Membranes Based on Polyelectrolyte/Polyimide Blend Precursors (2005)

Abstract We prepared dense flat‐sheet Ag‐functionalized carbon molecular‐sieve (CMS) membranes from blends of P84 co‐polyimide and a sulfonated poly(ether ether ketone) with a Ag + counterion (AgSPEEK). These blends offer the possibility of producing new functionalized precursor structures, which were previously not possible, such as integrally skinned asymmetric hollow fibers. Membranes prepared at a pyrolysis end temperature of 800 °C showed a maximum permeability for all tested gases at a Ag content of approximately 2.5 wt.‐% (He permeability P He = 465 Barrer (1 Barrer = 7.5 × 10 –18 m 2 s –1 Pa –1 ), P = 366 Barrer, P = 91.8 Barrer, P = 10.3 Barrer). The maximum achieved selectivity for O 2 over N 2 with CMS membranes based on these blends was α = 13.5 (Ag content: 4.5 wt.‐%, P = 52.7 Barrer). The CO 2 over N 2 selectivity reached a value of 48.9 (Ag content: 4.5 wt.‐%, P = 191 Barrer). These observations are explained by the formation of selective bypasses around Ag nanoclusters in the CMS matrix.