gebhart/patrepeval huggingface dataset:
Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty‐three papain workers: Evidence for strong immunogenic potency and clinically relevant ‘proteolytic effects of airborne papain’ (1982)

Seventeen out of thirty-three workers who have been exposed to airborne papain at their place of work regularly developed asthmatic symptoms such as shortness of breath, wheezing, coughing, sneezing, rhinorrhea and conjunctival irritation upon contact with this proteolytic enzyme. Investigations by RAST, skin test and bronchial provocation test proved IgE-mediated hypersensitivity to papain in fourteen symptomatic workers. Ten of these were in a screening investigation involving twenty-nine of the thirty-three workers; i.e. the incidence of IgE-mediated sensitization was 34.5% of this group. Bronchial provocation of as little as 0.001--0.5 mg of papain was shown to elicit immediate or dual asthmatic reactions in all eight tested workers with RAST values greater than 3 u/ml. On the other hand, inhalation of 0.5 mg of papain did not cause any remarkable change in non-exposed asthmatics. Occupation-related blood-stained nasal secretions and/or cutaneous flare reactions in all four heavily-exposed papain workers, of whom three had negative skin test and RAST results, suggest a direct effect of the proteolytically active enzyme on human tissue. There was a significant elevation (P less than 0.001) of serum trypsin inhibitory capacity in papain workers which seems to depend on the degree of exposure. No significant differences between symptomatic and asymptomatic workers in alpha 1-antitrypsin (Pi) phenotype subtypes were found.
Polyoma virus major capsid protein, VP1. Purification after high level expression in Escherichia coli. (1985)

We have expression-cloned in Escherichia coli the major polyoma virus capsid protein, VP1. Under the inducible control of the hybrid tac promoter, VP1 constituted between 2 and 3% of the total host cell protein. The expressed VP1 was purified to near homogeneity with initial yields to 10%. Optimal expression was temperature-dependent, and significant intracellular degradation could be demonstrated. The final product was obtained as one predominant isoelectric focusing species, without the pattern of post-translational modification seen in virus-infected eukaryotic cells. The purified VP1 from E. coli will be useful as a substrate for the purification of VP1 modification enzymes and in the study of inter-VP1 oligomerization.
A double-side filter based power line recognition method for UAV vision system (2013)

Automatic power line recognition from cluttered background is an important and challenging task for a vision based unmanned aerial vehicles (UAVs) power line inspection system. In this paper, we propose a power line recognition method based on liner object enhancement and parallel lines constraint. A new double-side filter is proposed to enhance the power lines, and then the radon transform is used to find the parallel lines as the power line recognition results. Our experiments on real image data captured from UAV demonstrate our method is effective for automatic power line recognition.
Isolation of Tannin-Degrading Lactobacilli from Humans and Fermented Foods (2000)

Lactobacilli with tannase activity were isolated from human feces and fermented foods. A PCR-based taxonomic assay revealed that the isolates belong to Lactobacillus plantarum, L. paraplantarum, and L. pentosus. Additional studies on a range of Lactobacillus species from established culture collections confirmed that this enzymatic activity is a phenotypic property common to these three species.
Atr-Ir Spectroscopy Study of NLC Orientation at the Plasma-Polymerized Layers Surface (1997)

Abstract The comparative analysis of ATR IR spectra of the CB molecules mixture aligned planar by a-C:H and homeotropic by PPO layers produced by CVD technique in plasma are done The dichroic ratios of main absorption bands of the spectra have been calculated The models of the intermolecular interaction mechanism of the CB with a-C:H and PPO layers in the absence of external field are discussed
공작연맹 주택전시회에서의 근대주택 조형 실험에 관한 연구 (2018)

The purpose of this study is to examine the innovative and experimental housing design alternatives in the transition period to the modern era and to discuss about the motivation of modern architectural form. Thus, first, this study examined the planning concepts and the meaning of new design of the four Werkbund dwelling Exhibitions in eastern Europe reflecting the demands of modern times. Second, I analyzed how the formative experiment appeared as a stereoscopic mass design and as a architectural composition in exterior. Experimental trials at housing exhibitions were to respond to the demands for the new forms, which required a new approach to modern style and aesthetics. The major features of formative experiments can be summarized as follows. First, new housing design have escaped from the historically descended style. Secondly, through the operation of volume and surface modern dwelling created a formative conformation. Finally, the shape and the surface replaced the decoration. In conclusion, the works of modern architects can be said to have achieved the harmony between 'purpose of expression' and 'technical purpose' in realizing the 'Zeitgeist' that corresponds to the paradigm of modern housing.
Efficient Structure Resonance Energy Transfer from Microwaves to Confined Acoustic Vibrations in Viruses (2015)

Virus is known to resonate in the confined-acoustic dipolar mode with microwave of the same frequency. However this effect was not considered in previous virus-microwave interaction studies and microwave-based virus epidemic prevention. Here we show that this structure-resonant energy transfer effect from microwaves to virus can be efficient enough so that airborne virus was inactivated with reasonable microwave power density safe for the open public. We demonstrate this effect by measuring the residual viral infectivity of influenza A virus after illuminating microwaves with different frequencies and powers. We also established a theoretical model to estimate the microwaves power threshold for virus inactivation and good agreement with experiments was obtained. Such structure-resonant energy transfer induced inactivation is mainly through physically fracturing the virus structure, which was confirmed by real-time reverse transcription polymerase chain reaction. These results provide a pathway toward establishing a new epidemic prevention strategy in open public for airborne virus.
Differential expression pattern of the novel serine/threonine kinase, STK33, in mice and men (2005)

Serine/threonine kinase 33 (STK33/Stk33) is a recently discovered gene whose inferred amino acid sequence translation displays characters typical for a calcium/calmodulin dependent kinase (CAMK). In this study we analysed the STK33/Stk33 RNA and protein distribution and the localization of the protein. The STK33/Stk33 expression pattern resembles those of some related members of the CAMK group. STK33/Stk33 displays a nonubiquitous and, in most tissues, low level of expression. It is highly expressed in testis, particularly in cells from the spermatogenic epithelia. Moreover, significant expression is detected in lung epithelia, alveolar macrophages, horizontal cells in the retina and in embryonic organs such as heart, brain and spinal cord. A possible role of STK33/Stk33 in spermatogenesis and organ ontogenesis is discussed.
Immunohistochemistry of Tissue Prepared by a Molecular-Friendly Fixation and Processing System (2005)

A recently introduced histologic fixative (Universal Molecular Fixative [UMFIX]) has been shown to preserve macromolecules in tissue at ambient temperature. When UMFIX-exposed tissues are processed by a formalin-free, microwave-assisted rapid processing system, the resulting paraffin blocks retain good histomorphology and intact nucleic acids suitable for expression microarray analysis. Because UMFIX may be used as an alternative to formalin, the authors set out to study the effect of this new fixation and processing system on immunohistochemistry (IHC) by analyzing a range of human neoplastic and non-neoplastic specimens. Parallel slices from surgically removed specimens were fixed in formalin and UMFIX and processed in a rapid microwave-assisted tissue processor. IHC was performed following routine procedures. The staining for those antibodies that normally required antigen retrieval was carried out with and without that step. The intensity and pattern of reactions were compared in 144 tissue samples fixed by the two methods using 70 monoclonal and polyclonal antibodies. The intensity of IHC reactions for most cytoplasmic antigens was generally equal or stronger in UMFIX tissues. This was particularly true with intermediate filaments and HercepTest, where the antigen retrieval step became unnecessary. Conversely, there was a decrease in the intensity of reactions for HepPar1, bcl-2, and three nuclear antigens (Ki-67, TTF-1, and estrogen receptor). Increasing their exposure times optimized the sensitivity of the latter four antibodies. The study shows that IHC staining results of tissues fixed in UMFIX and processed by the microwave-assisted system are comparable to those obtained on formalin-fixed, similarly processed specimens. There is an enhancement of the sensitivity of few antibodies in UMFIX-exposed tissue, rendering antigen retrieval unnecessary. This increased sensitivity may be due to the effect of eliminating formalin from fixation and processing or the microwave energy.
Label Propagation from ImageNet to 3D Point Clouds (2013)

Recent years have witnessed a growing interest in understanding the semantics of point clouds in a wide variety of applications. However, point cloud labeling remains an open problem, due to the difficulty in acquiring sufficient 3D point labels towards training effective classifiers. In this paper, we overcome this challenge by utilizing the existing massive 2D semantic labeled datasets from decade-long community efforts, such as Image Net and Label Me, and a novel ``cross-domain'' label propagation approach. Our proposed method consists of two major novel components, Exemplar SVM based label propagation, which effectively addresses the cross-domain issue, and a graphical model based contextual refinement incorporating 3D constraints. Most importantly, the entire process does not require any training data from the target scenes, also with good scalability towards large scale applications. We evaluate our approach on the well-known Cornell Point Cloud Dataset, achieving much greater efficiency and comparable accuracy even without any 3D training data. Our approach shows further major gains in accuracy when the training data from the target scenes is used, outperforming state-of-the-art approaches with far better efficiency.
Quarantine Procedure for Hawaiian Papaya Using Fruit Selection and a Two-stage Hot-water Immersion (1986)

A quarantine procedure for Hawaiian papaya was evaluated. The procedure involved selecting fruit less than one-quarter ripe and subjecting the fruit to a 30- or 40- min immersion in water at 42°C followed immediately by a second immersion for 20 min in water at 49°C. A computer model was developed that calculated the expected survival of oriental fruit fly, Dacus dorsalis Hendel, from the treatment. Experimental data confirmed the results of the computer simulation. The complete procedure was successfully tested under commercial conditions for 50,000 fruit.
Adhesion Enhancement through Micropatterning at Polydimethylsiloxane−Acrylic Adhesive Interfaces (2007)

Adhesion at polydimethylsiloxane (PDMS)-acrylic adhesive interfaces is shown to be enhanced through micropatterning of the PDMS substrate. By varying the geometry of the patterns (groves and hexagonal arrays of pillars of micrometer sizes, obtained through soft lithography techniques) and comparing rigid and deformable substrates, the respective roles of the geometry and the size and flexibility of the pattern features on the level of adhesion have been analyzed. For cylindrical pillars, two regimes are clearly identified: for a relatively low aspect ratio (h/r < 3, with h and r, respectively, the height and the radius of the pillars), soft patterned substrates are more efficient than rigid ones at increasing adhesion, pointing out the role of the elastic energy associated with the deformation of the pattern that is lost when the adhesive detaches from the substrate. Using scaling laws, the predominant contribution to that elastic energy can be further identified: deformation of the substrate underlying the pillars for h/r < 1.6 or bending of the pillars for h/r > 1.6.; for a high aspect ratio (h/r > 3), only rigid patterned substrates enhance adhesion, then the only possible contribution to energy dissipation comes from the enhanced viscoelastic losses associated with the pattern that induce modifications of the strain field within the adhesive layer. Soft, high aspect ratio patterns lose their efficiency even if still bent under the effect of the peel forces. This is because when bent, some of the pillars touch each other and remain stuck together, lying flat on the surface after the passage of the peel front. The bending elastic energy of the pillars (which is still lost) is then balanced by the corresponding gain in surface energy of the substrate in the peeled region. These systematic experiments demonstrate that the ability of the patterned surface to be deformed plays a crucial role in enhancing adhesion and allow us to propose a way to fine tune the level of adhesion at PDMS-acrylic adhesive interfaces, independently of the chemistry of the adhesive.
Blood Monocyte Subsets Differentially Give Rise to CD103+ and CD103− Pulmonary Dendritic Cell Populations (2008)

There are two major myeloid pulmonary dendritic cell (DC) populations: CD103+ DCs and CD11bhigh DCs. In this study, we investigated in detail the origins of both myeloid DC pools using multiple experimental approaches. We show that, in resting lung, Ly-6ChighCCR2high monocytes repopulated CD103+ DCs using a CCR2-dependent mechanism, and these DCs preferentially retained residual CCR2 in the lung, whereas, conversely, Ly-6ClowCCR2low monocytes repopulated CD11bhigh DCs. CX3CR1 was required to generate normal numbers of pulmonary CD11bhigh DCs, possibly because Ly-6Clow monocytes in the circulation, which normally express high levels of CX3CR1, failed to express bcl-2 and may have diminished survival in the circulation in the absence of CX3CR1. Overall, these data demonstrate that the two circulating subsets of monocytes give rise to distinct tissue DC populations.
Real-time microfacet billboarding for free-viewpoint video rendering (2004)

We present a hardware-accelerated method for video-based rendering relying on an approximate model of scene geometry. Our goal is to render high-quality views of the scene from arbitrary viewpoints in real-time, using as input synchronized video-streams from only a small number of calibrated cameras distributed around the scene. Despite the fact that only a very coarse geometry reconstruction is possible, our rendering approach based on textured billboards preserves the details present in the source images. By exploiting multi-texturing and blending facilities of modern graphics cards, we achieve real-time frame-rates on current off-the-shelf hardware. One of the possible applications of our algorithm is to use it in an inexpensive system to display 3D-videos, which the user can watch from an interactively chosen viewpoint, or ultimately even live 3D-television.
Progress in transparent flat-panel holographic displays enabled by guided-wave acousto-optics (2018)

We have previously introduced a monolithic, integrated optical platform for transparent, flat-panel holographic displays suitable for near-to-eye displays in augmented reality systems. This platform employs a guided-wave acousto-optic spatial light modulator implemented in lithium niobate in conjunction with an integrated Bragg-regime reflection volume hologram. In this paper, we depict analysis of three key system attributes that inform and influence the display system performance: 1) single-axis diffraction-driven astigmatism, 2) strobed illumination to enforce acousto-optic grating stationarity, and 3) acousto-optically driven spatial Nyquist rate.
The effect of a reduction in expired carbon dioxide on the attractiveness of human subjects to mosquitoes (1970)

The attractiveness, to mosquitoes, of human subjects breathing normally and wearing a breathing apparatus which removed 95·5% of expired carbon dioxide were compared in the field. Significantly fewer mosquitoes approached the subject with a reduced carbon-dioxide output. Species differences were apparent in the degree of reduction of mosquitoes at the bait, as measured by the ratio of numbers attracted to subjects without and with the breathing apparatus. From the results of trials in the Gambia, West Africa, this ratio gave values of 0·67 for Mansonioides spp., 0·46 for Anopheles gambiae Giles/ A. melas Theo. and 0·19 for Culex thalassius Theo., while complementary work in southern England gave a value of 0·34 for Aedes cantans (Mg.)/ Ae. annulipes (Mg.). A reduced carbon-dioxide output had no effect on the proportion of mosquitoes attempting to feed once within close range of the host. These findings confirm that carbon dioxide is a long- or medium-range attractant.
Clinical trial of plasma perfusion over immobilized staphylococcal protein A in metastatic breast cancer. (1987)

Nineteen patients with metastatic breast cancer refractory to conventional therapy were treated with plasma perfusion over 200 mg of staphylococcal Protein A immobilized on a silica matrix. Fever and chills (33%), pain at the site of tumor (18%), and dyspnea (16%) were the most frequent toxic effects encountered. Four patients (21%) developed a disseminated rash which necessitated cessation of treatment. Of 16 patients evaluable for response, one achieved a minor response of chest wall disease and two had no change in hepatic metastases for 4 and 5 months' duration. Potential mechanisms of antitumor effect are discussed.
Molecular profiling of the role of the NF-kappaB family of transcription factors during alloimmunity. (2002)

Allograft rejection involves a complex network of multiple immune regulators and effector mechanisms. In the current study, we focused on the role of nuclear factor (NF)-kappaB/Rel. Previous studies had established that deficiency of the p50 NF-kappaB family member prolonged allograft survival only modestly. However, because of its crucial role in signal transduction in inflammatory and immune responses, we hypothesized that other NF-kappaB/Rel family members may produce more profound effects on alloimmunity. Therefore, in addition to p50, we analyzed the role of c-Rel, which is expressed predominantly in lymphocytes. Also, to investigate NF-kappaB activation in T cells, we examined transgenic mice that express a transdominant inhibitor of NF-kappaB [IkappaB(DeltaN)] regulated by a T cell-restricted promoter. Allograft survival was prolonged indefinitely in the c-Rel-deficient and IkappaB(DeltaN)-transgenic recipients. To determine the molecular basis of NF-kappaB modulation of rejection, we analyzed a panel of 58 parameters including effector molecules, chemokines, cytokines, receptors, and cellular markers using hierarchical clustering algorithms and self-organizing maps in p50(-/-), c-Rel(-/-), and IkappaB(DeltaN)-transgenic, experimental groups plus allogeneic-, syngeneic-, and lymphocyte-deficient (alymphoid) control groups. Surprisingly, profiles of gene expression in the c-Rel recipients (which have indefinite graft survival) were similar to the p50(-/-) and allogeneic recipients (which rapidly reject grafts). As expected, gene expression in the IkappaB(DeltaN) recipients (which also have indefinite graft survival) was similar to profiles of nonrejecting syngeneic and alymphoid recipients. Importantly, self-organizing maps identified a small subset of genes including several chemokine receptors and cytokines with expression profiles that correlate with graft survival. Thus, our results demonstrate a crucial role for NF-kappaB in acute allograft rejection, identify different molecular mechanisms of rejection by distinct NF-kappaB family members, and identify a small subset of inducible genes whose inhibition is linked to graft acceptance.
Integrated PET/MR imaging: Automatic attenuation correction of flexible RF coils (2013)

The presence of flexible RF surface coils leads to considerable local errors in the simultaneously measured PET activity concentration up to 15.5% especially in regions close to the coils. The presented automatic algorithm accurately and reliably reduces the PET quantification errors caused by multiple partly overlapping flexible RF surface coils to values of 4.3% or better.
Molecular Mechanism of Peptide-Induced Pores in Membranes (2004)

We suggest a physical mechanism by which antimicrobial peptides spontaneously induce stable pores in membranes. Peptide binding to a lipid bilayer causes an internal stress, or internal membrane tension, that can be sufficiently strong to create pores. Like detergents, peptides have a high affinity for the rim of the pore. Binding to the rims reduces the line tension and decreases the number of peptides causing the internal membrane tension. Consequently, the pore radius is stable. The pore formation resembles a phase transition.
X Windowハンドブック = Introduction to the X Window System (1990)

Ｈｅｌｌｏ，Ｗｏｒｌｄ Ｘウィンドウの設計思想 ウィンドウ グラフィック テキスト カラー：ピクスマップ、ビットマップ、イメージ マウスとポインタ キーボード 高度なイベント処理 アプリケーション間通信 付録 Ｘ１１Ｒ４についてのドキュメント
Molecular determinants of tissue selectivity in estrogen receptor modulators (1997)

Interaction of the estrogen receptor/ligand complex with a DNA estrogen response element is known to regulate gene transcription. In turn, specific conformations of the receptor-ligand complex have been postulated to influence unique subsets of estrogen-responsive genes resulting in differential modulation and, ultimately, tissue-selective outcomes. The estrogen receptor ligands raloxifene and tamoxifen have demonstrated such tissue-specific estrogen agonist/antagonist effects. Both agents antagonize the effects of estrogen on mammary tissue while mimicking the actions of estrogen on bone. However, tamoxifen induces significant stimulation of uterine tissue whereas raloxifene does not. We postulate that structural differences between raloxifene and tamoxifen may influence the conformations of their respective receptor/ligand complexes, thereby affecting which estrogen-responsive genes are modulated in various tissues. These structural differences are 4-fold: (A) the presence of phenolic hydroxyls, (B) different substituents on the basic amine, (C) incorporation of the stilbene moiety into a cyclic benzothiophene framework, and (D) the imposition of a carbonyl "hinge" between the basic amine-containing side chain and the olefin. A series of raloxifene analogs that separately exemplify each of these differences have been prepared and evaluated in a series of in vitro and in vivo assays. This strategy has resulted in the development of a pharmacophore model that attributes the differences in effects on the uterus between raloxifene and tamoxifen to a low-energy conformational preference imparting an orthogonal orientation of the basic side chain with respect to the stilbene plane. This three-dimensional array is dictated by a single carbon atom in the hinge region of raloxifene. These data indicate that differences in tissue selective actions among benzothiophene and triarylethylene estrogen receptor modulators can be ascribed to discrete ligand conformations.