gebhart/patrepeval huggingface dataset:
Studies on semduramicin and nutritional responses: 3. Electrolyte balance (1999)

Four experiments were conducted to determine whether fluctuations in dietary electrolyte level (milliequivalents Na+K-Cl per kilogram) or different dietary sodium chloride levels would affect performance, water intake, or excreta moisture of chickens fed semduramicin vs nonmedicated controls. In all experiments, male commercial broiler chicks were used, and all diets were fed with and without 25 mg semduramicin/kg diet. The basal diets were based on corn, soybean meal, and poultry oil. Experiments 1, 3, and 4 were conducted using male broiler chicks in battery brooders to 18 d of age. In Experiment 1, six electrolyte levels were fed [basal (0.2% Na, 0.33% Cl, 1.10% K); basal plus 0.1% Na (from sodium chloride); basal plus 0.1% K (from potassium chloride); basal plus 0.2% Na (from sodium carbonate); basal plus 0.34% K (from potassium chloride); basal plus 0.15% Cl (from ammonium chloride)]. There were no significant changes in BW gain, feed consumption, or feed conversion ratio caused by any dietary treatment. Water consumption was not affected by the inclusion of Na, Cl, K, or electrolyte levels, but excreta moisture was affected. The highest and lowest excreta moisture levels came from chicks fed the lowest chloride levels. There were no significant dietary effects on serum Na, Cl, or K by dietary electrolytes or semduramicin. Experiment 2 was conducted with triplicate floor pens of 33 male broilers each for 42 d with four electrolyte levels [basal (0.2% Na, 0.34% Cl, 1.03% K); basal plus 0.1% Na (from sodium carbonate); basal plus 0.1% Cl (from ammonium chloride); basal plus 0.18% K (from potassium carbonate)]. Increasing electrolyte level had a significant effect on BW gain at 35 d but not at 42 d [mainly because of differences in K (1.943 kg at 35 d) vs Cl (2.013 kg at 35 d)]. At 42 d, there were no differences in growth because of N, K, Cl, or semduramicin. Potassium supplementation caused a significant increase in litter moisture (P = 0.031). Semduramicin did not affect litter moisture (P = 0.892), nor were there significant semduramicin interactions with Na, K, Cl, or semduramicin. The basal diets in Experiments 3 and 4 were identical to the basal diet in Experiment 1 except there was no sodium chloride added. The diets fed in Experiment 3 contained 0, 0.1, 0.2, 0.3, or 0.4% added sodium chloride. The diets fed in Experiment 4 contained 0.1, 0.3, 0.5, 0.7, and 0.9% added sodium chloride. The results of Experiments 3 and 4 show that about 0.4% added sodium chloride is necessary to achieve maximum growth and feed conversion. It is clear that semduramicin had no significant effect upon the variation observed in any of the variables measured.
METHYLOTROPHS: Genetics and Commercial Applications (1990)

Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly pathogenic HCoVs: severe acute respiratory syndrome coronavirus (SARS-CoV) and ...Read More
Prediction of protein–protein interaction sites in heterocomplexes with neural networks (2002)

In this paper we address the problem of extracting features relevant for predicting protein--protein interaction sites from the three-dimensional structures of protein complexes. Our approach is based on information about evolutionary conservation and surface disposition. We implement a neural network based system, which uses a cross validation procedure and allows the correct detection of 73% of the residues involved in protein interactions in a selected database comprising 226 heterodimers. Our analysis confirms that the chemico-physical properties of interacting surfaces are difficult to distinguish from those of the whole protein surface. However neural networks trained with a reduced representation of the interacting patch and sequence profile are sufficient to generalize over the different features of the contact patches and to predict whether a residue in the protein surface is or is not in contact. By using a blind test, we report the prediction of the surface interacting sites of three structural components of the Dnak molecular chaperone system, and find close agreement with previously published experimental results. We propose that the predictor can significantly complement results from structural and functional proteomics.
TCP-Friendly Multicast Congestion Control (TFMCC): Protocol Specification (2006)

This document specifies TCP-Friendly Multicast Congestion Control (TFMCC).TFMCC is a congestion control mechanism for multicast transmissions in a best-effort Internet environment.It is a single-rate congestion control scheme, where the sending rate is adapted to the receiver experiencing the worst network conditions.TFMCC is reasonably fair when competing for bandwidth with TCP flows and has a relatively low variation of throughput over time, making it suitable for applications where a relatively smooth sending rate is of importance, such as streaming media.
Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex. (1989)

Development of tolerance to self Ag occurs during a negative cell selection process in the thymus. This selection process is thought to involve interactions between Ag-specific thymocyte receptors and self Ag presented by the MHC proteins on accessory cells, resulting in deletion of potentially harmful self-reactive precursors. However, the mechanisms underlying this clonal deletion have not been identified. In confirmation of previous findings (C. A. Smith, G. T. Williams, R. Kingston, E. J. Jenkins, and J. J. T. Owen, 1989. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature 337:181), we have found that an anti-CD3 antibody stimulated DNA fragmentation, characteristic of a suicide mechanism known as apoptosis or programmed cell death (PCD), in suspensions of human thymocytes. Endonuclease activation and cell killing were dependent on an early, sustained increase in cytosolic Ca2+ concentration, most of which was of extracellular origin. Although the magnitude and duration of the Ca2+ increase were similar to those observed in response to Con A, the mitogen did not stimulate DNA fragmentation or cell death. Phorbol ester prevented Ca2+-dependent DNA fragmentation and cell killing in response to anti-CD3 or other agents that stimulated PCD, suggesting that activation of protein kinase C abrogated cell suicide. Disappearance of CD4+CD8+ immature thymocytes was generally observed in response to all agents that stimulated PCD, whereas mature PBL were insensitive to stimulation of PCD. Our results suggest that antibody-mediated stimulation of immature thymocytes via the TCR complex results in Ca2+-dependent, endonuclease-mediated cell killing, depending on the activation status of protein kinase C.
Efficient Traveling-wave Accelerating Structure for Linear Accelerators (2008)

The shaped traveling-wave (STW) structure contains periodic structure of cavities with optimal shape and magnetic coupling operating in the forward travelingwave mode. The structure combines the advantages of conventional standing-wave (SW) and traveling-wave (TW) structures. It ensures high efficiency of the use of radio-frequency (RF) power for the particle acceleration inherent in the SW structures. Also it gives a possibility to vary output energy of the particles by changing the beam loading and provides for good matching with RF generator without application of special matching devices that is inherent in the TW structures. The STW structure is well suited for compact variable-energy electron linear accelerators used for radiation technologies.
Hollow steel tips for reducing distal fiber burn-back during thulium fiber laser lithotripsy (2013)

The use of thulium fiber laser (TFL) as a potential alternative laser lithotripter to the clinical holmium:YAG laser is being studied. The TFL's Gaussian spatial beam profile provides efficient coupling of higher laser power into smaller core fibers without proximal fiber tip degradation. Smaller fiber diameters are more desirable, because they free up space in the single working channel of the ureteroscope for increased saline irrigation rates and allow maximum ureteroscope deflection. However, distal fiber tip degradation and "burn-back" increase as fiber diameter decreases due to both excessive temperatures and mechanical stress experienced during stone ablation. To eliminate fiber tip burn-back, the distal tip of a 150-μm core silica fiber was glued inside 1-cm-long steel tubing with fiber tip recessed 100, 250, 500, 1000, or 2000 μm inside the steel tubing to create the hollow-tip fiber. TFL pulse energy of 34 mJ with 500-μs pulse duration and 150-Hz pulse rate was delivered through the hollow-tip fibers in contact with human calcium oxalate monohydrate urinary stones during ex vivo studies. Significant fiber tip burn-back and degradation was observed for bare 150-μm core-diameter fibers. However, hollow steel tip fibers experienced minimal fiber burn-back without compromising stone ablation rates. A simple, robust, compact, and inexpensive hollow fiber tip design was characterized for minimizing distal fiber burn-back during the TFL lithotripsy. Although an increase in stone retropulsion was observed, potential integration of the hollow fiber tip into a stone basket may provide rapid stone vaporization, while minimizing retropulsion.
Pooling acoustic and lexical features for the prediction of valence (2017)

In this paper, we present an analysis of different multimodal fusion approaches in the context of deep learning, focusing on pooling intermediate representations learned for the acoustic and lexical modalities. Traditional approaches to multimodal feature pooling include: concatenation, element-wise addition, and element-wise multiplication. We compare these traditional methods to outer-product and compact bilinear pooling approaches, which consider more comprehensive interactions between features from the two modalities. We also study the influence of each modality on the overall performance of a multimodal system. Our experiments on the IEMOCAP dataset suggest that: (1) multimodal methods that combine acoustic and lexical features outperform their unimodal counterparts; (2) the lexical modality is better for predicting valence than the acoustic modality; (3) outer-product-based pooling strategies outperform other pooling strategies.
ABC1: connecting yellow tonsils, neuropathy, and very low HDL (1999)

In 1960, the most common surgical procedure performed on children was tonsillectomy. During one such routine operation, an astute physician recognized that the tonsils of his 5-year-old patient from Tangier Island were anything but ordinary (1). The tonsils were strikingly large, lobulated, and lemoncolored. The tonsils of the patient’s sister were similarly abnormal in appearance and had a 50- to 100-fold elevated content of cholesteryl ester. The siblings also shared another remarkable trait: both had extremely low plasma levels of HDL cholesterol (HDL-C). These children were the index cases of Tangier disease, a genetic disorder characterized by an abnormal plasma lipoprotein profile — virtual absence of HDL-C, reduced levels of LDL cholesterol (LDL-C) with mildly or moderately elevated triglycerides, and
The Effects of Language Relatedness on Multilingual Information Retrieval: A Case Study With Indo-European and Semitic Languages. (2008)

We explore the effects of language relatedness within a multilingual information retrieval (IR) framework which can be deployed to virtually any language, focusing specifically on Indo-European versus Semitic languages. The Semitic languages present unique challenges to IR for a number of reasons, so we set out to answer the question of whether cross-language IR for Semitic languages can be boosted by manipulation of the training data (which, in our framework, includes multilingual parallel text, some of which is morphologically analyzed). We attempted three measures to achieve this: first, the inclusion of genetically related (i.e., other Semitic) languages in the training data; second, the inclusion of non-related languages sharing the same script, and third, the inclusion of morphological analysis for Semitic languages. We find that language relatedness is a definite factor in boosting IR precision; script similarity can probably be ruled out as a factor; and morphological analysis can be helpful, but – perhaps paradoxically – not necessarily to the languages which are subjected to morphological analysis. 1
Investigations in Heterocycles. XV. Methylphenidate: A Versatile Intermediate in the Synthesis of Bicyclic Heterocycles with a Bridgehead Nitrogen Atom (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigations in Heterocycles. XV. Methylphenidate: A Versatile Intermediate in the Synthesis of Bicyclic Heterocycles with a Bridgehead Nitrogen AtomGeorge DeStevens and Marcel BernierCite this: J. Med. Chem. 1964, 7, 2, 146–149Publication Date (Print):March 1, 1964Publication History Published online1 May 2002Published inissue 1 March 1964https://pubs.acs.org/doi/10.1021/jm00332a006https://doi.org/10.1021/jm00332a006research-articleACS PublicationsRequest reuse permissionsArticle Views161Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Error resilient video coding techniques (2000)

We review error resilience techniques for real-time video transport over unreliable networks. Topics covered include an introduction to today's protocol and network environments and their characteristics, encoder error resilience tools, decoder error concealment techniques, as well as techniques that require cooperation between encoder, decoder, and the network. We provide a review of general principles of these techniques as well as specific implementations adopted by the H.263 and MPEG-4 video coding standards. The majority of the article is devoted to the techniques developed for block-based hybrid coders using motion-compensated prediction and transform coding. A separate section covers error resilience techniques for shape coding in MPEG-4.
Suppression of the biosynthesis of proanthocyanidin in <i>Arabidopsis</i> by a chimeric PAP1 repressor (2004)

Flavonoids are secondary metabolites that are specific to higher plants. PAP1, a member of the family of MYB domain transcription factors in Arabidopsis, is a positive regulator of the biosynthesis of anthocyanin. We show here that a chimeric PAP1 repressor, in which the EAR-motif repression domain from SUPERMAN was fused to PAP1, suppressed the expression of four flavonoid biosynthetic genes, namely CHS, DFR, LDOX, and BAN, in siliques, and inhibited the accumulation of proanthocyanidin, even in the presence of an endogenous positive regulator, such as TT2. This suppression resulted in the formation of light yellow seeds in 35S::PAP1SRDX transgenic plants. Our results indicate that PAP1 has the potential ability to regulate the biosynthesis not only of anthocyanin but also of proanthocyanidin. Our gene silencing system, using chimeric repressors, appears to be a useful tool for the manipulation of the biosynthesis of secondary metabolites in plants.
A Software System for Locating Mobile Users: Design, Evaluation, and Lessons (2000)

We have built a software system, RADAR, to locate mobile users connected to an in-building radiofrequency (RF) wireless LAN. RADAR uses signal strength information extracted from the wireless network interface, in conjunction with a Radio Map of the building, to determine location. Over the past year we have deployed this system in multiple buildings on our campus using two different wireless LAN technologies and two widely used operating systems. This experience has led us to identify some shortcomings of the basic RADAR system and fundamental limitations in the way wireless network hardware is abstracted in contemporary operating systems. To address the shortcomings, we present several novel algorithms, including an environmental profiling algorithm to compensate for the vagaries of the RF environment, and a history-based algorithm for continuous user tracking. Performance evaluation of these algorithms using extensive data collected from our deployments shows that the accuracy of p...
Discovery of Inhibitors That Overcome the G1202R Anaplastic Lymphoma Kinase Resistance Mutation (2015)

The treatment of patients with advanced non-small-cell lung cancer harboring chromosomal rearrangements of anaplastic lymphoma kinase (ALK) has been revolutionized by the development of crizotinib, a small-molecule inhibitor of ALK, ROS1, and MET. However, resistance to crizotinib inevitably develops through a variety of mechanisms, leading to relapse both systemically and in the central nervous system (CNS). This has motivated the development of “second-generation” ALK inhibitors, including alectinib and ceritinib, that overcome some of the mutations leading to resistance. However, most of the reported ALK inhibitors do not show inhibition of the G1202R mutant, which is one of the most common mutations. Herein, we report the development of a structural analogue of alectinib (JH-VIII-157-02) that is potent against the G1202R mutant as well as a variety of other frequently observed mutants. In addition, JH-VIII-157-02 is capable of penetrating the CNS of mice following oral dosing.
Dementia of the Alzheimer Type (1986)

An Inventory presenting characteristics useful in the clinical identification of dementia of the Alzheimer type (DAT) is presented. The Inventory includes aphasia, amnesia, abnormal cognition and visuospatial skills, inappropriate lack of concern, and normal motor functions. In a retrospective study of 50 consecutive dementia patients, the DAT Inventory correctly identified 100% of DAT subjects and 94% of non-DAT cases. Utilization of positive criteria can aid in the identification of DAT and can facilitate recognition of treatable illnesses masquerading as DAT.
Atomic physicochemical parameters for three dimensional structure directed quantitative structure‐activity relationships III: Modeling hydrophobic interactions (1988)

Abstract In an earlier article 8 the need was demonstrated for atomic physicochemical properties for three dimensional structure directed quantitative structure‐activity relationships, and it was shown how atomic parameters can be developed for successfully evaluating the molecular octanol‐water partition coefficient, which is a measure of hydrophobicity. In this work we report more refined atomic values of octanol‐water partition coefficients derived from nearly twice the number of compounds. Carbon, hydrogen, oxygen, nitrogen, sulfur and halogens are divided into 110 atom types of which 94 atomic values are evaluated from 830 molecules by least squares. These values gave a standard deviation of 0.470 and a correlation coefficient of 0.931. These parameters predicted the octanol‐water partition coefficient of 125 compounds with a standard deviation of 0.520 and a correlation coefficient of 0.870. There is only a correlation coefficient of 0.432 between the atomic octanol‐water partition coefficients and the atomic contributions to molar refractivity over the 93 atom types used for both the properties. This suggests that both parameters can be used simultaneously to model intermolecular interactions. We evaluated the CNDO/2 gross atomic charge distribution over several molecules to check the validity of our classification. We found that the charge density on the heteroatoms in conjugated systems is strongly affected by the presence of similar atoms in the conjugation which suggests it should be incorporated as a separate parameter in evaluating the partition coefficient.
A novel presenilin 1 mutation associated with Pick's disease but not β‐amyloid plaques (2004)

Familial forms of frontotemporal dementia (FTD) with tauopathy are mostly caused by mutations in the gene encoding the microtubule-associated protein tau (MAPT). However, rare forms of familial tauopathy without MAPT mutations have been reported, suggesting other tauopathy-related genetic defects. Interestingly, two presenilin 1 (PS1) mutations (Leu113Pro and insArg352) recently have been associated with familial FTD albeit without neuropathological confirmation. We report here a novel PS1 mutation in a patient with Pick-type tauopathy in the absence of extracellular beta-amyloid deposits. The mutation is predicted to substitute Gly-->Val at codon position 183 (Gly183Val) and to affect the splice signal at the junction of the sixth exon and intron. Further clinical-genetic investigation showed a positive family history of FTD-like dementia and suggested that Gly183Val is associated with a phenotypically heterogeneous neurodegenerative disorder. Our results suggest PS1 as a candidate gene for Pick-type tauopathy without MAPT mutations.
Algorithm and DSP-implementation for a speaker-independent single-word speech recognizer with additional speaker-dependent say-in facility (2002)

We present a novel system implementation concept for small-vocabulary single-word speech recognition. The system can recognize speaker-independently a number of preprogrammed words, and additionally it can perform recognition of a number of words which have been trained by simple say-in. In contrast to other implementations, one and the same algorithm is used for both speaker-dependent and speaker-independent recognition. This implies that in our proposed system the fixed (speaker-independent) part and the personalized (speaker-dependent) part of the vocabulary can be activated simultaneously, which is mandatory for the use in mobile communication systems. Compared to state-of-the-art speaker-dependent recognition systems, the RAM capacity for storing the personalized part of the vocabulary is drastically reduced. The recognition rate is comparable to that of a fully speaker-independent system. A DSP implementation of the speech recognition system is described.
Effect of platelet activating factor on the kinetics of LDL oxidation in vitro (1993)

Oxidatively modified low-density-lipoprotein (LDL) might contribute to the atherosclerotic process. This study was performed to examine an effect of platelet-activating factor (PAF) and of synthetic PAF analogs on Cu(II) induced oxidation of LDL in vitro: The D- and L-isomers of PAF and analogs with short-chain sn-2-substituents, 1-O-alkyl-2-butyryl-sn-glycero-3-phosphocholine and 1-O-alkyl-2-heptanoyl-sn-glycero-3-phosphocholine, were found to be the most effective inhibitors of LDL oxidation. Oxidation was inhibited completely at PAF concentrations above 100 microM. Lyso-PAF and analogs carrying longer chains at the sn-2 position were less effective. These results thus provide evidence for the involvement of other parameters in LDL oxidation beyond the content of natural antioxidants like vitamin E and beta-carotene.
Genes with a spike expression are clustered in chromosome (sub)bands and spike (sub)bands have a powerful prognostic value in patients with multiple myeloma (2011)

We present a new approach to identify spike genes and their relationship to patients' survival.