gebhart/patrepeval huggingface dataset:
Virtual High Throughput Screening Confirmed Experimentally: Porous Coordination Polymer Hydration (2009)

Hydrothermal stability is a pertinent issue to address for many industrial applications where percent levels of water can be present at temperatures ranging from subambient to several hundred degrees. Our objective is to understand relative stabilities of MOF materials through experimental testing combined with molecular modeling. This will enable the ultimate design of materials with improved hydrothermal stability, while maintaining the properties of interest. The tools that we have employed for these studies include quantum mechanical calculations based upon cluster models and combinatorial steaming methods whereby a steam stability map was formulated according to the relative stability of different materials. The experimental steaming method allows for high throughput screening of materials stability over a broad range of steam levels as well as in-depth investigation of structural transformations under more highly resolved conditions, while the cluster model presented here yields the correct trends in hydrothermal stability. Good agreement was observed between predicted relative stabilities of materials by molecular modeling and experimental results. Fundamental information from these studies has provided insight into how metal composition and coordination, chemical functionality of organic linker, framework dimensionality, and interpenetration affect the relative stabilities of PCP materials. This work suggests that the strength of the bond between the metal oxide cluster and the bridging linker is important in determining the hydrothermal stability of the PCP. Although the flexibility of the framework plays a role, it is not as important as the metal-linker bond strength. This demonstration of alignment between experimental and calculated observations has proven the validity of the method, and the insight derived herein insight facilitates direction in designing ideal MOF materials with improved hydrothermal stability for desired applications.
Identification of cellular TSG101 protein in multiple human breast cancer cell lines. (1997)

tsg101 was identified as a tumor susceptibility gene by homozygous functional inactivation of allelic loci in mouse 3T3 fibroblasts. The human homologue was mapped at chromosome 11p15.1-2 and found to have intragenic deletion in 7 of 15 breast cancer specimens. To further confirm the relevance of defects in this gene to breast cancer, antibodies specific for the putative gene product were prepared and used to identify cellular TSG101 protein. The antibodies recognized a 46-kDa protein in human retinoblastoma WERI-27 cells labeled with [35S]methionine. This protein was not detected with preimmune sera. In cell fractionation studies, the 46-kDa protein cofractionating with glutathione S-transferase was found mainly in the cytoplasm. Similarly, when cells were immunostained with anti-TSG101 antibodies, fluorescence was localized in the cytoplasm of most of the cells. A full-size 46-kDa TSG101 protein was detected in a panel of 10 breast cancer cell lines and 2 normal breast epithelial cell lines with the same antibodies. Consistently, the full-length TSG101 mRNA was also detected in these breast cells using reverse transcription-PCR. These results indicate that homozygous intragenic deletion of TSG101 is rare in breast cancer cells.
Secure WWW transactions using standard HTTP and Java applets (1998)

Can users access information on the Web securely with their unchanged, normal broswers, and yet without relying on the cryptographic software contained in those browsers? In this paper we show that this is possible, with a communication architecture based on Java applets. This is important, because cryptographic functions need be separated from both the user interface and the communications routines. It must be possible to acquire the source code for the relevant modules and alternative software vendors must be available, in order to avoid hidden trapdoors and undetected implementation problems. Our approach is alternative to solutions at the protocol level (e.g., SSL), because the unchanged HTTP/TCP/IP stack is maintained. Moreover, it does not require the installation of proxies.
ChemInform Abstract: Antineoplastic Agents. Part 370. Isolation and Structure of Dolastatin 18. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Model of a synthetic wind speed time series generator (2007)

Abstract Wind energy has assumed a great relevance in the operation and planning of today's power systems due to the exponential increase of installations in the last 10 years. For this reason, many performed studies have looked at suitable representations of wind generation for power system analysis. One of the main elements to consider for this purpose is the model of the wind speed that is usually required as input. Wind speed measurements may represent a solution for this problem, but, for techniques such as sequential Monte Carlo simulation, they have to be long enough in order to describe a wide range of possible wind conditions. If these information are not available, synthetic wind speed time series may be a useful tool as well, but their generator must preserve statistical and stochastic features of the phenomenon. This paper deals with this issue: a generator for synthetic wind speed time series is described and some statistical issues (seasonal characteristics, autocorrelation functions, average values and distribution functions) are used for verification. The output of the model has been designed as input for sequential Monte Carlo simulation; however, it is expected that it can be used for other similar studies on wind generation. Copyright © 2007 John Wiley &amp; Sons, Ltd.
The development of immune therapy with HSP60 for juvenile idiopathic arthritis (2003)

Immune regulation is an important mechanism in controlling the severity and duration of an immune response. Ongoing and destructive inflammation suggests a dysfunction in the immune regulation, while a spontaneous relapse or remission of disease suggests a successful immune-regulatory process. Understanding the regulatory mechanisms that control the balance between immunity and tolerance can provide potential new targets for therapeutic intervention.
Mechanisms of synaptic dysfunction in Alzheimer's disease. (1995)

Alzheimer's disease (AD) is characterized by a progressive cognitive decline in which memory, initiation, learning and conceptualization are severely affected. The main histopathological alterations are the presence of amyloid beta/A4-containing plaques, tangles and amyloid angiopathy. It is believed that these brain alterations are associated with abnormal expression and/or processing of amyloid precursor protein (APP) and with abnormal assembly of cytoskeletal proteins. Recent quantitative studies with the electron microscope and with immunochemical/immunocytochemical assays, using molecular markers for synaptic proteins, have shown that synaptic loss in the cortex is the major correlate of the patterns of cognitive decline in AD. The synaptic loss in AD is accompanied by neuronal loss and aberrant sprouting, and studies in incipient AD cases have shown that this alteration occurs very early in the progression of the disease preceding tangle formation and neuronal loss. These results suggest that damage to the synaptic terminal plays a central role in the pathogenesis of AD. The mechanisms of synaptic pathology in AD are not yet clear, however, studies in transgenic animal models support the possibility that APP participates in synaptic stabilization and that abnormal metabolism of this molecule could lead to synaptic dysfunction which, in turn, results in neurodegeneration and dementia.
Mitochondrial Dysfunction in Retinal Diseases (2011)

The mitochondrion is a vital intracellular organelle for retinal cell function and survival. There is growing confirmation to support an association between mitochondrial dysfunction and a number of retinal degenerations. Investigations have also unveiled mitochondrial genomic instability as one of the contributing factors for age-related retinal pathophysiology. This review highlights the role of mitochondrial dysfunction originating from oxidative stress in the etiology of retinal diseases including diabetic retinopathy, glaucoma and age-related macular degeneration (AMD). Moreover, mitochondrial DNA (mtDNA) damage associated with AMD due to susceptibility of mtDNA to oxidative damage and failure of mtDNA repair pathways is also highlighted in this review. The susceptibility of neural retina and retinal pigment epithelium (RPE) mitochondria to oxidative damage with ageing appears to be a major factor in retinal degeneration. It thus appears that the mitochondrion is a weak link in the antioxidant defenses of retinal cells. In addition, failure of mtDNA repair pathways can also specifically contribute towards pathogenesis of AMD. This review will further summarize the prospective role of mitochondria targeting therapeutic agents for the treatment of retinal disease. Mitochondria based drug targeting to diminish oxidative stress or promote repair of mtDNA damage may offer potential alternatives for the treatment of various retinal degenerative diseases.
Embedded Linux Primer: A Practical Real-World Approach (2006)

Comprehensive Real-World Guidance for Every Embedded Developer and EngineerThis book brings together indispensable knowledge for building efficient, high-value, Linux-based embedded products: information that has never been assembled in one place before. Drawing on years of experience as an embedded Linux consultant and field application engineer, Christopher Hallinan offers solutions for the specific technical issues you're most likely to face, demonstrates how to build an effective embedded Linux environment, and shows how to use it as productively as possible.Hallinan begins by touring a typical Linux-based embedded system, introducing key concepts and components, and calling attention to differences between Linux and traditional embedded environments. Writing from the embedded developer's viewpoint, he thoroughly addresses issues ranging from kernel building and initialization to bootloaders, device drivers to file systems.Hallinan thoroughly covers the increasingly popular BusyBox utilities; presents a step-by-step walkthrough of porting Linux to custom boards; and introduces real-time configuration via CONFIG_RT--one of today's most exciting developments in embedded Linux. You'll find especially detailed coverage of using development tools to analyze and debug embedded systems--including the art of kernel debugging. Compare leading embedded Linux processors Understand the details of the Linux kernel initialization process Learn about the special role of bootloaders in embedded Linux systems, with specific emphasis on U-Boot Use embedded Linux file systems, including JFFS2--with detailed guidelines for building Flash-resident file system images Understand the Memory Technology Devices subsystem for flash (and other) memory devices Master gdb, KGDB, and hardware JTAG debugging Learn many tips and techniques for debugging within the Linux kernel Maximize your productivity in cross-development environments Prepare your entire development environment, including TFTP, DHCP, and NFS target servers Configure, build, and initialize BusyBox to support your unique requirementsAbout the AuthorChristopher Hallinan, field applications engineer at MontaVista software, has worked for more than 20 years in assignments ranging from engineering and engineering management to marketing and business development. He spent four years as an independent development consultant in the embedded Linux marketplace. His work has appeared in magazines, including Telecommunications Magazine, Fiber Optics Magazine, and Aviation Digest.
Saving the world wide web from vulnerable JavaScript (2011)

JavaScript is the most popular client-side scripting language for Web applications. Exploitable JavaScript code exposes end users to integrity and confidentiality violations. Client-side vulnerabilities can cost an enterprise money and reputation, and cause serious damage to innocent users of the Web application. In spite of all this, recent research in the area of information-flow security has focused more on other languages that are more suitable for server-side programming, such as Java.
Evaluation of Advanced Polymers for Additive Manufacturing (2017)

The goal of this Manufacturing Demonstration Facility (MDF) technical collaboration project between Oak Ridge National Laboratory (ORNL) and PPG Industries, Inc. (PPG) was to evaluate the feasibility of using conventional coatings chemistry and technology to build up material layer-by-layer. The PPG-ORNL study successfully demonstrated that polymeric coatings formulations may overcome many limitations of common thermoplastics used in additive manufacturing (AM), allow lightweight nozzle design for material deposition, and increase build rate. The materials effort focused on layer-by-layer deposition of coatings with each layer fusing together. The combination of materials and deposition results in an additively manufactured build that has sufficient mechanical properties to bear the load of additional layers, yet is capable of bonding across the z-layers to improve build direction strength. The formulation properties were tuned to enable a novel, high-throughput deposition method that is highly scalable, compatible with high loading of reinforcing fillers, and inherently low-cost.
한국의 가맹희망자들의 가맹사업 선택기준 (2013)

적합한 가맹사업 지원자들의 부족은 프랜차이즈 시스템의 성장과 분야의 확장을 제한할수 있다. 그러나 기존에는 이러한 문제에 대한 연구가 거의 이루어지지 않았다. 본 연구는 문헌에서의 지식 갭을 좁히고자 하는 의도에서 수행되었다. 가맹사업자의 가맹본부 선정기준에 관한 탐구는 가맹사업자가 가맹본부로부터 무엇을 찾는지를 결정하는 것부터 제공, 자영업 서장이 되는 것을 가장 중요한 가맹본부 선정기준으로 고려하고 있었다. 또한 본 연구에서는 프랜차이즈 박람회를 프랜차이즈 정보를 얻는 중요 한 수단으로 보고 있다는 점도 밝혔으며, 가맹희망자들이 가맹본부로부터의 지속적인 지원도 기대하고 있음을 확인할 수 있었다. 이러한 발견점들은 가맹본부의 가맹사업자 모집 전략에 시사점을 준다.
A Simple Method for Constructing E1- and E1/E4-Deleted Recombinant Adenoviral Vectors (1999)

We previously developed a two-plasmid in vitro ligation method that did not require a recombination step to produce new recombinant E1- or E1/E3-deleted adenoviral vectors. In this study, we have modified the system to improve the simplicity of vector construction and, in addition, to allow for production of an E1/E4-deleted vector.
Dietary-Fat Intake in the US Population (1999)

The study showed individuals whose diets included low-fat foods are more likely to have a diet that meets the dietary guidelines recommendations for fat and saturated fat.
From Disulfide‐ to Thioether‐Linked Glycoproteins (2008)

Strengthening the bond: The introduction of a thiol tag in combination with chemoselective ligation to form a disulfide-linked bioconjugate is a selective and useful method for site-selective protein glycosylation. The phosphine-mediated desulfurization of such glycoconjugates to their reductant-resistant thioether-linked counterparts completes a convergent, site-selective synthesis of thioether-linked glycoproteins (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z704381_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Membranes for Redox Flow Battery Applications (2012)

The need for large scale energy storage has become a priority to integrate renewable energy sources into the electricity grid. Redox flow batteries are considered the best option to store electricity from medium to large scale applications. However, the current high cost of redox flow batteries impedes the wide spread adoption of this technology. The membrane is a critical component of redox flow batteries as it determines the performance as well as the economic viability of the batteries. The membrane acts as a separator to prevent cross-mixing of the positive and negative electrolytes, while still allowing the transport of ions to complete the circuit during the passage of current. An ideal membrane should have high ionic conductivity, low water intake and excellent chemical and thermal stability as well as good ionic exchange capacity. Developing a low cost, chemically stable membrane for redox flow cell batteries has been a major focus for many groups around the world in recent years. This paper reviews the research work on membranes for redox flow batteries, in particular for the all-vanadium redox flow battery which has received the most attention.
Phenyl Substituted 4-Hydroxypyridazin-3(2<i>H</i>)-ones and 5-Hydroxypyrimidin-4(3<i>H</i>)-ones: Inhibitors of Influenza A Endonuclease (2014)

Seasonal and pandemic influenza outbreaks remain a major human health problem. Inhibition of the endonuclease activity of influenza RNA-dependent RNA polymerase is attractive for the development of new agents for the treatment of influenza infection. Our earlier studies identified a series of 5- and 6-phenyl substituted 3-hydroxypyridin-2(1H)-ones that were effective inhibitors of influenza endonuclease. These agents identified as bimetal chelating ligands binding to the active site of the enzyme. In the present study, several aza analogues of these phenyl substituted 3-hydroxypyridin-2(1H)-one compounds were synthesized and evaluated for their ability to inhibit the endonuclease activity. In contrast to the 4-aza analogue of 6-(4-fluorophenyl)-3-hydroxypyridin-2(1H)-one, the 5-aza analogue (5-hydroxy-2-(4-fluorophenyl)pyrimidin-4(3H)-one) did exhibit significant activity as an endonuclease inhibitor. The 6-aza analogue of 5-(4-fluorophenyl)-3-hydroxypyridin-2(1H)-one (6-(4-fluorophenyl)-4-hydroxypyridazin-3(2H)-one) also retained modest activity as an inhibitor. Several varied 6-phenyl-4-hydroxypyridazin-3(2H)-ones and 2-phenyl-5-hydroxypyrimidin-4(3H)-ones were synthesized and evaluated as endonuclease inhibitors. The SAR observed for these aza analogues are consistent with those previously observed with various phenyl substituted 3-hydroxypyridin-2(1H)-ones.
Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations (1999)

Hypocretin (orexin) has recently been shown to increase feeding when injected into the brain. Using both rat and primate brains, we tested the hypothesis that a mechanism of hypocretin action might be related to synaptic regulation of the neuropeptide Y (NPY) system. Hypocretin-immunoreactive terminals originating from the lateral hypothalamus make direct synaptic contact with neurons of the arcuate nucleus that not only express NPY but also contain leptin receptors. In addition, hypocretin-containing neurons also express leptin receptor immunoreactivity. This suggests a potential mechanism of action for hypocretin in the central regulation of metabolic and endocrine processes. The excitatory actions of hypocretin could increase NPY release, resulting in enhanced feeding behavior and altered endocrine regulation, whereas leptin, released from adipose tissue as an indicator of fat stores, would have the opposite effect on the same neurons, leading to a decrease in NPY and NPY-mediated hypothalamic functions. On the other hand, the innervation of hypocretin cells by NPY boutons raises the possibility that NPY may exert an effect on hypothalamic functions, at least in part, via mediation or feedback action on these lateral hypothalamic cells. Our data indicate that a direct interaction between leptin, hypocretin, and NPY exists in the hypothalamus that may contribute to the central regulation of metabolic and endocrine processes in both rodents and primates.
Structural and inflammatory changes in COPD: a comparison with asthma. (1998)

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality.In Europe COPD and asthma, together with pneumonia, are the third most common cause of death.In North America COPD is the fourth leading cause of death, and mortality rates and prevalence are increasing.The incidence and morbidity from COPD are rising.The main risk factors are cigarette smoking and occupational exposure.
Modulating lipid fate controls lipotoxicity in palmitate‐treated hepatic cells (2013)

Lipotoxicity from free fatty acid overload has been implicated in a variety of diseased states including Type II Diabetes and nonalcoholic fatty liver disease (NAFLD). Our central hypothesis is that overexposure to saturated fatty acids (SFAs) leads to increased saturation of ER membrane phospholipids, which alters membrane stability, induces ER stress and ultimately leads to lipoapoptosis. Our objective is to determine how perturbations of pathways involved in lipid metabolism can modulate SFA‐induced lipotoxicity in terms of reactive oxygen species (ROS) accumulation, caspase activation, phospholipid composition, ER stress and cell death. Stimulation of β‐oxidation with the AMPK activator AICAR reduced the lipotoxic phenotype stemming from SFA overload in H4IIEC3 hepatomas, while inhibition of this pathway with the specific CPT‐1 inhibitor Etomoxir had no positive effect on the outcome of the hepatic cells. Cells co‐treated with oleate (OA), a monounsaturated fatty acid, demonstrated increased triglyceride synthesis but almost a complete reversal of all characterizations of the lipotoxic phenotype. Our data indicates that by modulating alternative pathways of lipid metabolism in hepatic cells, the lipotoxic effects of SFAs can be significantly reduced. This work is funded by National Science Foundation Career Award 0955251.
Solubilities of Terephthalaldehydic, <i>p</i>-Toluic, Benzoic, Terephthalic, and Isophthalic Acids in <i>N</i>-Methyl-2-pyrrolidone from 295.65 K to 371.35 K (2000)

Using a laser monitoring observation technique, the solubilities of terephthalaldehydic acid, p-toluic acid, benzoic acid, terephthalic acid, and isophthalic acid in N-methyl-2-pyrrolidone were determined by the synthetic method from (295.65 to 371.35) K. The experimental results were correlated by an empirical equation.