gebhart/patrepeval huggingface dataset:
Real‐Time Weighted Pose‐Space Deformation on the GPU (2006)

Abstract WPSD (Weighted Pose Space Deformation) is an example based skinning method for articulated body animation. The per‐vertex computation required in WPSD can be parallelized in a SIMD (Single Instruction Multiple Data) manner and implemented on a GPU. While such vertex‐parallel computation is often done on the GPU vertex processors, further parallelism can potentially be obtained by using the fragment processors. In this paper, we develop a parallel deformation method using the GPU fragment processors. Joint weights for each vertex are automatically calculated from sample poses, thereby reducing manual effort and enhancing the quality of WPSD as well as SSD (Skeletal Subspace Deformation). We show sufficient speed‐up of SSD, PSD (Pose Space Deformation) and WPSD to make them suitable for real‐time applications . Categories and Subject Descriptors (according to ACM CCS): I.3.1 [Computer Graphics]: Hardware Architecture‐Parallel processing, I.3.5 [Computer Graphics]: Computational Geometry and Object Modeling‐Curve, surface, solid and object modeling, I.3.7 [Computer Graphics]: Three‐Dimensional Graphics and Realism‐Animation.
Altered reactivity to measles virus. Atypical measles in children previously immunized with inactivated measles virus vaccines (1967)

An atypical measles illness occurred in ten children who had received inactivated (killed) measles virus vaccine five to six years earlier. The illness is characterized by a two- to three-day prodrome of fever and complaints of pain (head, muscle, and abdomen, or both muscle and abdomen) followed by the development of a maculopapular rash with petechial, vesicular, and urticarial components. Peripheral edema and pneumonia occurred in almost all the children. In three instances, significant pleural effusions were noted. Serologic determinations established the diagnosis in all ten children, but measles virus was recovered from none of them.
Peptide-Modified Optical Filters for Detecting Protease Activity (2007)

The organic derivatization of silicon-based nanoporous photonic crystals is presented as a method to immobilize peptides for the detection of protease enzymes in solution. A narrow-line-width rugate filter, a one-dimensional photonic crystal, is fabricated that exhibits a high-reflectivity optical resonance that is sensitive to small changes in the refractive index at the pore walls. To immobilize peptide in the pore of the photonic crystal, the hydrogen-terminated silicon surface was first modified with the alkene 10-succinimidyl undecenoate via hydrosilylation. The monolayer with the succinimide ester moiety at the distal end served the dual function of protecting the underlying silicon from oxidation as well as providing a surface suitable for subsequent derivatization with amines. The surface was further modified with 1-aminohexa(ethylene glycol) (EG(6)) to resist nonspecific adsorption of proteins common in complex biological samples. The distal hydroxyl of the EG(6) is activated using the solid-phase coupling reagent disuccinimidyl carbonate for selective immobilization of peptides as protease recognition elements. X-ray photoelectron spectroscopy analysis reveals high activation and coupling efficiency at each stage of the functionalization. Exposure of the peptide-modified crystals to the protease subtilisin in solution causes a change in the refractive index, resulting in a shift of the resonance to shorter wavelengths, indicating cleavage of organic material within the pores. The lowest detected concentration of enzyme was 37 nM (7.4 pmol in 200 microL).
Tracking Cell Signaling Protein Expression and Phosphorylation by Innovative Proteomic Solutions (2004)

The most challenging and fruitful biomedical research endeavor of this decade will be the mapping of cell signaling systems and establishing their linkages to normal and disease-related processes. Amongst other things, the Human Genome Sequencing Project has greatly facilitated MALDI-TOF mass spectrometry identification of proteins that have been resolved by standard 2D gel electrophoresis. However, the low abundance of protein kinases and other signal transduction proteins has rendered their analyses particularly problematic without some means of purification and enrichment from cell and tissue lysates. Antibodies have been the most specific affinity probes for tracking target proteins, but their variable quality and high cost preclude their deployment in most discovery-based proteomics studies. Current multi-immunoblotting techniques can permit the probing of a single mini-SDS-PAGE gel with 50 or more antibodies at a time to monitor large changes in the expression and phosphorylation states of signaling proteins. The development of new affinity probes to replace antibodies is necessary to drive large scale proteomics studies. Such affinity probes could include short peptide antibody mimetics (PAM's) and oligonucleotide aptamers that when spotted in 2D array formats (e.g. membrane macroarrays, glass microarrays) or presented on specific beads (e.g. Luminex beads) can capture target proteins for their specific enrichment. The bound target proteins can then be detected using reporter antibodies or other specific probes for their quantitation by high throughput systems. These new proteomics methodologies will accelerate assessment of specific protein expression, post-translational modification, protein-protein interactions and protein-drug interactions to provide a more holistic view of cellular operations and how they might be manipulated under pathological circumstances.
Smartphone-based blood pressure monitoring via the oscillometric finger-pressing method (2018)

High blood pressure (BP) is a major cardiovascular risk factor that is treatable, yet hypertension awareness and control rates are low. Ubiquitous BP monitoring technology could improve hypertension management, but existing devices require an inflatable cuff and are not compatible with such anytime, anywhere measurement of BP. We extended the oscillometric principle, which is used by most automatic cuff devices, to develop a cuff-less BP monitoring device using a smartphone. As the user presses her/his finger against the smartphone, the external pressure of the underlying artery is steadily increased while the phone measures the applied pressure and resulting variable-amplitude blood volume oscillations. A smartphone application provides visual feedback to guide the amount of pressure applied over time via the finger pressing and computes systolic and diastolic BP from the measurements. We prospectively tested the smartphone-based device for real-time BP monitoring in human subjects to evaluate usability (<i>n</i> = 30) and accuracy against a standard automatic cuff-based device (<i>n</i> = 32). We likewise tested a finger cuff device, which uses the volume-clamp method of BP detection. About 90% of the users learned the finger actuation required by the smartphone-based device after one or two practice trials. The device yielded bias and precision errors of 3.3 and 8.8 mmHg for systolic BP and -5.6 and 7.7 mmHg for diastolic BP over a 40 to 50 mmHg range of BP. These errors were comparable to the finger cuff device. Cuff-less and calibration-free monitoring of systolic and diastolic BP may be feasible via a smartphone.
Junction Integrity for Low Temperature Dopant Activation in Silicon (2006)

Detailed within this paper is investigation of using low temperature processes to activate dopant in silicon. Parameters studied include breakdown voltage, turn-on voltage, leakage current, and ideality factor. Strong correlation was seen between the temperature of activation and both the ideality factor and leakage current. Breakdown voltage seemed constant except for the highest temperature processing. Turn-on voltage seemed to change for boron activation, but not for phosphorus activation
Zinc Promoted Mild and Efficient Method for the Esterification of Acid Chlorides with Alcohols (1998)

Abstract The esterification of variety of acid chlorides with alcohols in the presence of zinc is described. The easy formation of t-butyl and pivaloyl esters are the additional importance of this procedure.
Molecular cloning and functional expression of the pituitary adenylate cyclase-activating polypeptide type I receptor. (1993)

Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide belonging to the vasoactive intestinal peptide (VIP)/secretion/glucagon family of peptides, interacts with a distinct high-affinity receptor (type I receptor) on a number of tissues. These PACAP type I receptors have a high affinity for PACAP and a low affinity for VIP and are present in the hypothalamus and anterior pituitary, where they regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, and prolactin, and in the adrenal medulla, where they regulate the release of epinephrine. Type I PACAP receptors are also present in high concentrations in testicular germ cells, where they may regulate spermatogenesis, and some transformed cell lines, such as the rat pancreatic acinar carcinoma cell AR4-2J. Here we report the molecular cloning and functional expression of the PACAP type I receptor isolated from an AR4-2J cell cDNA library by cross-hybridization screening with a rat VIP receptor cDNA. The cDNA sequence encodes a unique 495-amino acid protein with seven transmembrane domains characteristic of guanine nucleotide-binding regulatory protein-coupled receptors. A high degree of sequence homology with the VIP, secretin, glucagon-like peptide 1, parathyroid, and calcitonin receptors suggests its membership in this subfamily of Gs-coupled receptors. Results of binding studies and stimulation of cellular cAMP accumulation in COS-7 cells transfected with this cDNA are characteristic of a PACAP type I receptor. Cloning of the PACAP type I receptor will enhance our understanding of its distribution, structure, and functional properties and ultimately increase our understanding of its physiological role.
An Improved Method for Consistent Replicated Data in the Intelligent Network (2005)

The Intelligent Network (IN) is a novel architectural concept for telecommunication networks that enables network operators as well as independent service providers to swiftly introduce new services into networks. Furthermore, these services can be made flexible enough so that after deployment, service subscribers can directly tailor them to their requirements. The main idea behind the IN concept is the separation of switching functionality from service control. In order to achieve a high degree of flexibility the service logic is realized by software modules called service logic programs which can be customized with subscriber specific data. Thus, a large amount of data (service logic programs, subscriber specific data and management information) needs to be handled. As telecommunication systems are of highly parallel nature the main problem for the database system is to provide consistent data for all these service logic programs running at the same time. Using a centralized DBMS to control data consistency will rapidly lead to a bottleneck. Therefore you have to deal with distributed databases having the problem of heavy communication to provide data consistency. If you intend to replicate data (fully or partially) over the whole distributed system due to performance reasons and reliability then the communication overhead further increases because of the synchronization of the replicas. We developed a concept for the specific needs of the IN. It can be seen as a replicated database system having lower communication overhead than classical distributed database systems. It also impresses by its ease of scalabilig. In this talk we will first look at the IN architecture, then discuss our concept in detail and finally show how it can be integrated into the IN.
Plant-derived enzyme inhibitors and lectins for resistance against plant-parasitic nematodes in transgenic crops (1998)

Due to increasing restrictions on the use of toxic and expensive nematicides, there is now a greater than ever need for crop cultivars that are resistant to plant-parasitic nematodes. Genetically engineered nematode resistance is not as well developed as other engineered traits but, even so, the first genetically modified plants with enhanced nematode resistance have been produced and tested. Plant-derived enzyme inhibitor and lectin genes are being evaluated for their ability to confer broad-spectrum nematode resistance in transgenic crop plants. Early indications are that these are likely to be effective. Gene pyramiding has potential to increase field durability and to widen the spectrum of nematodes controlled by any one transgenic line. © 1998 SCI.
Spectral holography of shaped femtosecond pulses (1992)

Storage and subsequent recall of shaped femtosecond waveforms is achieved by performing spectral holography within a femtosecond pulse-shaping apparatus. Readout of the spectral hologram by using a short reference pulse yields both real and time-reversed reconstructions of the original signal. Convolution and correlation operations are achieved by using shaped pulses for readout. These experiments demonstrate the possibility of nonlinear spectral filtering and signal processing of femtosecond optical waveforms.
A review on phospholipids and their main applications in drug delivery systems (2014)

Phospholipids have the characteristics of excellent biocompatibility and a especial amphiphilicity. These unique properties make phospholipids most appropriate to be employed as important pharmaceutical excipients and they have a very wide range of applications in drug delivery systems. The aim of this review is to summarize phospholipids and some of their related applications in drug delivery systems, and highlight the relationship between the properties and applications, and the effect of the species of phospholipids on the efficiency of drug delivery. We refer to some relevant literatures, starting from the structures, main sources and properties of phospholipids to introduce their applications in drug delivery systems. The present article focuses on introducing five types of carriers based on phospholipids, including liposomes, intravenous lipid emulsions, micelles, drug-phospholipids complexes and cochleates.
Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis (2008)

Intratumoral innate immunity can play a significant role in blocking the effective therapeutic spread of a number of oncolytic viruses (OVs). Histone deacetylase inhibitors (HDIs) are known to influence epigenetic modifications of chromatin and can blunt the cellular antiviral response. We reasoned that pretreatment of tumors with HDIs could enhance the replication and spread of OVs within malignancies. Here, we show that HDIs markedly enhance the spread of vesicular stomatitis virus (VSV) in a variety of cancer cells in vitro, in primary tumor tissue explants and in multiple animal models. This increased oncolytic activity correlated with a dampening of cellular IFN responses and augmentation of virus-induced apoptosis. These results illustrate the general utility of HDIs as chemical switches to regulate cellular innate antiviral responses and to provide controlled growth of therapeutic viruses within malignancies. HDIs could have a profoundly positive impact on the clinical implementation of OV therapeutics.
Fluorine in Si: Native-defect complexes and the suppression of impurity diffusion (2005)

The transient enhanced diffusion of acceptor impurities severely affects the realization of ultrahigh doping regions in miniaturized Si-based devices. Fluorine codoping has been found to suppress this transient diffusion, but the mechanism underlying this effect is not understood. It has been proposed that fluorine-impurity or fluorine--native-defect interactions may be responsible. Here we clarify this mechanism combining first-principles theoretical studies of fluorine in Si and purposely designed experiments on Si structures containing boron and fluorine. The central interaction mechanism is the preferential binding of fluorine to Si-vacancy dangling bonds and the consequent formation of vacancy-fluorine complexes. The latter effectively act as traps for the excess self-interstitials that would normally cause boron transient enhanced diffusion. Instead, fluorine-boron interactions are marginal and do not play any significant role. Our results are also consistent with other observations such as native-defect trapping and bubble formation.
Right Coronary Artery to Left Ventricle Fistula (1973)

A case of a 29-year-old man with abnormal shadow of the heart complicated with bacterial endocarditis and hemiplegia is presented.Cardiac catheterization and angiography revealed a right coronary artery to left ventricle fistula which was saccularly dilated and tortuous. This is the sixth case in the literature.The literature is reviewed and shortly discussed.
Synthesis of Aza-, Oxa-, and Thiabicyclo[3.1.0]hexane Heterocycles from a Common Synthetic Intermediate (2005)

[reaction: see text] An efficient and stereospecific approach to the synthesis of structurally constrained aza-, oxa-, and thiabicyclo[3.1.0]hexane heterocycles has been achieved through application of the intramolecular cyclopropanation reaction of diazoacetates. The various constrained heterocycles (X = N, O, or S) are conveniently prepared from a common diol intermediate accessible from readily available cinnamyl alcohols. Application of the methodology to the synthesis of conformationally constrained oxazolidinone antibacterials is also discussed.
Implementation of Minimum Inventory Variability Scheduling 1-Step Ahead Policy(R) in a large semiconductor manufacturing facility (2002)

This paper describes an implementation of the 1-Step Ahead Minimum Inventory Variability Resource Scheduling Policy(R), in a large semiconductor facility (FAB) over the period from May, 1996, through January, 1997. The FAB described here uses a product release policy based on customer orders and a work-in-progress (WIP) chart. The scheduling of resource tools was done on a first in, first out (FIFO) basis on high speed tools and due date first (DDF) at bottleneck tools, except for high priority lots, called MAXIs. The FAB is discussed in generic terms (sanitized) because of the proprietary nature of the devices manufactured. Percentages of change in cycle time and output are presented.
Degradation of Hydrocarbons by Members of the Genus <i>Candida</i> II. Oxidation of <i>n</i> -Alkanes and 1-Alkenes by <i>Candida lipolytica</i> (1967)

Candida lipolytica ATCC 8661 was grown in a mineral-salts hydrocarbon medium. n-Alkanes and 1-alkenes with 14 through 18 carbon atoms were used as substrates. Ether extracts of culture fluids and cells obtained from cultures grown on the various substrates were analyzed by thin-layer and gas-liquid chromatography. Analyses of fluids from cultures grown on n-alkanes indicated a predominance of fatty acids and alcohols of the same chain length as the substrate. In addition, numerous other fatty acids and alcohols were present. Analyses of saponifiable and nonsaponifiable material obtained from the cells revealed essentially the same products. The presence of primary and secondary alcohols, as well as fatty acids, of the same chain length as the n-alkane substrate suggested that attack on both the methyl and alpha-methylene group was occurring. The significance of these two mechanisms in the degradation of n-alkanes by this organism was not evident from the data presented. Analyses of fluids from cultures grown on 1-alkenes indicated the presence of 1,2-diols, as well as omega-unsaturated fatty acids, of the same chain length as the substrate. Alcohols present were all unsaturated. Saponifiable and nonsaponifiable material obtained from cells contained essentially the same products. The presence of 1,2-diols and omega-unsaturated fatty acids of the same chain length as the substrate from cultures grown on 1-alkenes indicated that both the terminal methyl group and the terminal double bond were being attacked.
Design, Synthesis, and Biological Evaluation of a Series of Benzo[<i>de</i>][1,7]naphthyridin-7(8<i>H</i>)-ones Bearing a Functionalized Longer Chain Appendage as Novel PARP1 Inhibitors (2013)

A series of benzo[de][1,7]naphthyridin-7(8H)-ones possessing a functionalized long-chain appendage have been designed and evaluated as novel PARP1 inhibitors. The initial effort led to the first-generation PARP1 inhibitor 26 bearing a terminal phthalazin-1(2H)-one framework and showing remarkably high PARP1 inhibitory activity (0.31 nM) but only moderate potency in the cell. Further effort generated the second-generation lead 41, showing high potency against both the PARP1 enzyme and BRCA-deficient cells, especially for the BRCA1-deficient MDA-MB-436 cells (CC50 < 0.26 nM). Mechanistic studies revealed that the new PARP1 inhibitors significantly inhibited H2O2-triggered PARylation in SKOV3 cells, induced cellular accumulation of DNA double-strand breaks, and impaired cell-cycle progression in BRCA2-deficient cells. Significant potentiation on the cytotoxicity of Temozolomide was also observed. The unique structural character and exceptionally high potency of 41 made it stand out as a promising drug candidate worthy for further evaluation.
Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion (1997)

In the insulinoma cell line INS-1, a model system for glucose-regulated insulin secretion, the mitogen-activating protein (MAP) kinases/extracellular signal-regulated protein kinases, ERK1 and ERK2 are activated up to 15-fold by physiological concentrations of glucose, in the range of 3-12 mM. The related MAP kinase family members, the c-Jun-N-terminal kinases/stress-activated protein kinases are insensitive to glucose, while the p38 MAP kinase is slightly glucose responsive (1.5-fold). ERK activation is dependent on glucose metabolism and the subsequent increase in calcium influx. Inhibiting activation of ERK1 and ERK2 with the MEK1/2 inhibitor PD98059 has no effect on insulin secretion, indicating that ERK activity is not necessary for secretion under these conditions. Glucose activates ERK1 and ERK2 in cytosolic and purified nuclear fractions of INS-1 cells and more of each is found in nuclei from glucose-treated cells. These findings suggest that some of the glucose-dependent actions of ERKs will be exerted in the nucleus.
Trickling Filter Mythology (1999)

Engineering practice in trickling filter design has been influenced by the propagation of myths as much as by the analysis of data and factual determinations. In this paper, several common myths encountered by the writer in his engineering practice are examined. The myths are tied to source(s) where possible, and then the factual underpinnings (if any) are examined. Common myths include the following: (1) Trickling filter processes are less reliable than activated sludge processes; (2) trickling filters are poor performers in cold weather; (3) trickling filters are more expensive; (4) motorized distributor speed control is always needed; (5) cross-flow media should not be used at total organic loadings exceeding 1.6 kg BOD5/m3⋅d and (6) all media are created equal.
Subspace Method For Blind Separation Of Sources In Convolutive Mixture. (1996)

Publication in the conference proceedings of EUSIPCO, Trieste, Italy, 1996