gebhart/patrepeval huggingface dataset:
Wearable sensor platform and mobile application for use in cognitive behavioral therapy for drug addiction and PTSD (2011)

We present a wearable sensor platform designed for monitoring and studying autonomic nervous system (ANS) activity for the purpose of mental health treatment and interventions. The mobile sensor system consists of a sensor band worn on the ankle that continuously monitors electrodermal activity (EDA), 3-axis acceleration, and temperature. A custom-designed ECG heart monitor worn on the chest is also used as an optional part of the system. The EDA signal from the ankle bands provides a measure sympathetic nervous system activity and used to detect arousal events. The optional ECG data can be used to improve the sensor classification algorithm and provide a measure of emotional "valence." Both types of sensor bands contain a Bluetooth radio that enables communication with the patient's mobile phone. When a specific arousal event is detected, the phone automatically presents therapeutic and empathetic messages to the patient in the tradition of Cognitive Behavioral Therapy (CBT). As an example of clinical use, we describe how the system is currently being used in an ongoing study for patients with drug-addiction and post-traumatic stress disorder (PTSD).
Production of Nitric Oxide Using a (2002)

Nitric monoxide (NO) is increasingly being used in medical applications. Currently, a gas cylinder of N mixed with a high concentration of NO is used. This arrangement is poten- tially risky due to the possibility of accidental leak of NO from the cylinder. The presence of NO in air leads to the formation of nitric dioxide (NO ), which is toxic to the lungs. Therefore, an on-site generation of NO would be very desirable for patients with acute respiratory distress syndrome and other related illnesses. We have recently reported on the production of NO using a pulsed arc discharge. In the present work, the discharge reactor was made simpler and smaller. NO was generated using a pulsed arc discharge in dry air and in mixtures of oxygen and nitrogen. The composition of the gas mixture after treatment with an arc discharge followed by exposure to heated molybdenum was 540 ppm of NO, 48 ppm of NO , and the balance dry air at 0.1 MPa and 300 3 K. No ozone was detected at the outlet of the system by UV absorption. The density of the brass particles emitted from the electrodes, which had diameters over 0.3 m, was less than 1.39 g/L. A filter could readily capture and thus remove the brass particles.
Protection by recombinant human superoxide dismutase in lethal rat endotoxemia. (1989)

In summary as mechanism of the overall protective effect of r-HSOD in lethal rat endotoxemia, inhibition of hemoconcentration, a tendency of a decreased leukocyte activation and attenuation of consumption coagulopathy could be established.
Dishing and erosion in STI CMP (2003)

The effect of pattern density, trench width and selectivity of slurry on dishing and erosion in STI CMP process was investigated by using specially designed isolation pattern. As trench width gets wider and active pattern density gets higher, dishing becomes more severe. Low selectivity slurry shows less dishing at over 20 /spl mu/m trench width, whereas high selectivity slurry shows less dishing at below 20 /spl mu/m trench. Erosion of low active pattern density area is more severe and it is not affected by trench width. Generally, high selectivity slurry induces less erosion.
Poly(3-hexylthiophene)-<i>block</i>-poly(pyridinium phenylene)s: Block Polymers of p- and n-Type Semiconductors (2011)

Conjugated crystalline−crystalline donor−acceptor−donor block copolymer semiconductors, with regioregular poly(3-hexylthiophene) as a donor (p-type) block and poly(pyridinium pheneylene) as an acceptor (n-type) block within the backbone, were produced by sequential Grignard metathesis synthesis of poly(3-hexylthiophene), a Yamamoto-type cross-coupling polymerization−cyclization sequence. These conjugated block copolymers are soluble in organic solvents and display broad optical absorption bands extending close to the near-infrared region. They show reversible ambipolar redox properties with high electron affinities of 3.8−4.0 eV as well as useful ionization potentials of 5.1 eV that are characteristic of the respective blocks. Block copolymers from p- and n-type organic semiconductors are of interest for the formation of nanostructured bulk heterojunctions in photovoltaic devices.
Diblock, ABC triblock, and random methacrylic polyampholytes: synthesis by group transfer polymerization and solution behavior (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiblock, ABC triblock, and random methacrylic polyampholytes: synthesis by group transfer polymerization and solution behaviorC. S. Patrickios, W. R. Hertler, N. L. Abbott, and T. A. HattonCite this: Macromolecules 1994, 27, 4, 930–937Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/ma00082a008https://doi.org/10.1021/ma00082a008research-articleACS PublicationsRequest reuse permissionsArticle Views1097Altmetric-Citations188LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Selection of Glyphosate-Tolerant Tobacco Calli and the Expression of this Tolerance in Regenerated Plants (1985)

From nonmutagenized haploid suspensions of Nicotiana tabacum L. cv Wisconsin 38 cells, 51 cell lines capable of growth in the presence of 1 millimolar glyphosate (N-phosphonomethyl glycine) were initially isolated at a frequency of 2.3 x 10(-8). Eighteen cell lines retained tolerance when grown on selective medium for 3 years. Tolerance persisted for at least 14 months in six cell lines cultured in the absence of glyphosate. Some plants regenerated from four glyphosate-tolerant cell lines were tolerant. Glyphosate-tolerant tissue was isolated from some sensitive as well as some tolerant regenerated plants. Six of the tolerant cell lines were also tolerant to the herbicide amitrole (3-amino-1,2,4-triazole). Five cell lines selected for amitrole tolerance were glyphosate tolerant. Some plants regenerated from three of these five cell lines were glyphosate tolerant and glyphosate-tolerant tissue was obtained from several of these regenerated plants. Amitrole uptake in suspension cultures of several variants was assessed in terms of influx rate constants. This parameter was not sufficiently different indicating that altered membrane properties could not account for the herbicide tolerance.
RNA Aptamers Selected against the GluR2 Glutamate Receptor Channel (2007)

The excessive activation of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors, a subtype of glutamate ion channels, has been implicated in various neurological diseases such as cerebral ischemeia and amyotrophic lateral sclerosis. Inhibitors of AMPA receptors are drug candidates for potential treatment of these diseases. Using the systematic evolution of ligands by exponential enrichment (SELEX), we have selected a group of RNA aptamers against the recombinant GluR2Qflip AMPA receptor transiently expressed in HEK-293 (human embryonic kidney) cells. One of the aptamers, AN58, is shown to competitively inhibit the receptor. The nanomolar affinity of AN58 rivals that of NBQX (6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione), one of the best competitive inhibitors. Like NBQX, AN58 has the highest affinity for GluR2, the selection target, among all AMPA receptor subunits. However, AN58 has a higher selectivity for the GluR4 AMPA receptor subunit and remains potent even at pH = 6.8 (i.e., a clinically relevant acidic pH), as compared with NBQX. Furthermore, this RNA molecule possesses stable physical properties. Therefore, AN58 serves as a unique lead compound for developing water-soluble inhibitors with a nanomolar affinity for GluR2 AMPA receptors.
Urocortin 2 Lowers Blood Pressure and Reduces Plasma Catecholamine Levels in Mice with Hyperadrenergic Activity (2010)

Exaggerated adrenergic activity is associated with human hypertension. The peptide urocortin 2 (Ucn 2) inhibits catecholamine synthesis and secretion from adrenal chromaffin cells in vitro and administration to mammals lowers blood pressure (BP). The chromogranin A-null mouse (Chga-/-) manifests systemic hypertension because of excessive catecholamine secretion from the adrenal and decreased catecholamine storage. In the present study, we investigated whether systemic administration of Ucn 2 could reduce BP and adrenal and plasma levels of catecholamines in vivo. Ucn 2 peptide was administered to freely moving, conscious Chga-/- and wild-type control mice. Telemetry and HPLC measured changes in BP and catecholamine levels, respectively. In both groups of mice, Ucn 2 dose-dependently decreased BP, and this effect was mediated by corticotropin factor-receptor type 2. However, in Chga-/- mice, the maximal percentage decrease of systolic BP from basal systolic BP was 37% compared with only a 23% reduction in wild-type mice (P=0.04). In Chga-/- mice only, Ucn 2 decreased adrenal and plasma levels of catecholamines as well as adrenal levels of tyrosine hydroxylase protein and phosphorylation. In vitro mechanistic studies demonstrated that Ucn 2 reduces both catecholamine secretion and tyrosine hydroxylase promoter activity, suggesting that the exaggerated action of Ucn 2 to reduce BP in the Chga-/- mouse is mediated through inhibition of both catecholamine synthesis and secretion. The data suggest that Ucn 2 may be therapeutically useful in regulating the exaggerated sympathoadrenal function of hyperadrenergic hypertension.
Conceptual spaces: the geometry of thought (2000)

A new theory of conceptual representations as a bridge between the symbolic and connectionist approaches.
An efficient dynamic scheduling algorithm for multiprocessor real-time systems (1998)

Many time-critical applications require predictable performance and tasks in these applications have deadlines to be met. In this paper, we propose an efficient algorithm for nonpreemptive scheduling of dynamically arriving real-time tasks (aperiodic tasks) in multiprocessor systems. A real-time task is characterized by its deadline, resource requirements, and worst case computation time on p processors, where p is the degree of parallelization of the task. We use this parallelism in tasks to meet their deadlines and, thus, obtain better schedulability compared to nonparallelizable task scheduling algorithms. To study the effectiveness of the proposed scheduling algorithm, we have conducted extensive simulation studies and compared its performance with the myopic scheduling algorithm. The simulation studies show that the schedulability of the proposed algorithm is always higher than that of the myopic algorithm for a wide variety of task parameters.
Automated rendezvous and docking: A parametric study (1984)

A technique for achieving autonomous rendezvous and docking of two orbiting space vehicles is described. Results of a digital computer simulation of the technique are presented and used to evaluate its performance under a wide variety of conditions, including docking with tumbling spacecraft. The interrelationships between initial range, tumbling rates, fuel consumption, and time requirements are explored. Factors which limit performance are identified and beneficial modifications proposed.
Arrays of gated field-emitter cones having 0.32 μm tip-to-tip spacing (1994)

We have reduced the gate voltage required to achieve a given emission current density in field-emitter arrays by scaling down the gate-to-tip and tip-to-tip spacing to the unprecedented levels of 0.08 and 0.32 μm, respectively. The submicrometer features of our arrays are patterned using interferometric lithography. Electrical tests of arrays we have fabricated have shown a record low turn-on voltage of 8 V for cesiated molybdenum emitters. Emission current densities of 1600 A/cm2 have been obtained, which is also a record for such structures. These arrays provide large advantages for applications such as flat panel displays and microwave devices.
Management of gastroenteritis. (1990)

Childhood gastroenteritis remains a common reason for admission to British paediatric units, although the severity of the disease appears to be diminishing in recent years. We studied 215 infants and children with gastroenteritis admitted consecutively to four paediatric units in South Wales in order to determine the severity of the disease, the organisms isolated, the frequency of complications, and the adequacy of management before admission. Stool pathogens were isolated in 125 (58%) patients (viruses in 65, bacteria in 30, and protozoa in 19, with multiple infection found in 11). There was a low incidence of morbidity and complications, but prolonged diarrhoea (postenteritis syndrome) was present in 24 (11%) cases and 77 (36%) had received inappropriate treatment before admission. Contemporary gastroenteritis is thus a relatively mild disease in the acute phase, but management before admission to hospital is often inadequate, and prolonged diarrhoea may be a feature in a considerable number of cases.
<i>Candida</i>Biofilms: an Update (2005)

Our classical perception of microorganisms as unicellular life forms is almost entirely based on the pure-culture mode of growth; since microbial suspensions can be diluted to a single cell and studied in liquid culture, this mode of growth has traditionally predominated in the study of microbial physiology and pathogenesis in the research laboratory. However, many microbes in their natural habitats are found in biofilm ecosystems attached to surfaces and not as free-floating (planktonic) organisms (20, 21, 27). Thus, biofilms are defined as structured microbial communities that are attached to a surface and encased in a matrix of exopolymeric material. This is of particular significance since it is now estimated that a significant proportion of all human microbial infections involve biofilm formation (20, 22, 25, 26, 29, 48).
ESR Zero Estimation and Auto-compensation in Digitally Controlled Buck Converters (2009)

A method for estimating and compensating the zero introduced by the capacitor equivalent series resistance (ESR) in the buck converter transfer function is introduced. The method is well-suited for practical implementation with digital controllers. The ESR zero is estimated by online measurement of the output voltage ripple and the power stage corner frequency. Accordingly, the coefficients of the PID compensator are updated to avoid potential stability problems. Theoretical basis of the identification and the compensator design are presented. The method is experimentally verified on a 12V-to-1.5V, 500 kHz, 10W buck converter prototype.
Cellular Phones and Risk of Brain Tumors (2001)

As cellular telephones are a relatively new technology, we do not yet have long-term follow-up on their possible biological effects. However, the lack of ionizing radiation and the low energy level emitted from cell phones and absorbed by human tissues make it unlikely that these devices cause cancer. Moreover, several well-designed epidemiologic studies find no consistent association between cell phone use and brain cancer. It is impossible to prove that any product or exposure is absolutely safe, especially in the absence of very long-term follow-up. Accordingly, the following summary from the Food and Drug Administration Center for Devices and Radiological Health offers advice to people concerned about their risk: If there is a risk from these products--and at this point we do not know that there is--it is probably very small. But if people are concerned about avoiding even potential risks, there are simple steps they can take to do so. People who must conduct extended conversations in their cars every day could switch to a type of mobile phone that places more distance between their bodies and the source of the RF, since the exposure level drops off dramatically with distance. For example, they could switch to: a mobile phone in which the antenna is located outside the vehicle, a hand-held phone with a built-in antenna connected to a different antenna mounted on the outside of the car or built into a separate package, or a headset with a remote antenna to a mobile phone carried at the waist. Again the scientific data do not demonstrate that mobile phones are harmful. But if people are concerned about the radiofrequency energy from these products, taking the simple precautions outlined above can reduce any possible risk. In addition, people who are concerned might choose digital rather than analog telephones, since the former use lower RF levels.
RNA interference and the use of small interfering RNA to study gene function in mammalian systems (2004)

In the past 2 years, extraordinary developments in RNA interference (RNAi)-based methodologies have seen small interfering RNAs (siRNA) become the method of choice for researchers wishing to target specific genes for silencing. In this review, an historic overview of the biochemistry of the RNAi pathway is described together with the latest advances in the RNAi field. Particular emphasis is given to strategies by which siRNAs are used to study mammalian gene function. In this regard, the use of plasmid-based and viral vector-based systems to mediate long-term RNAi in vitro and in vivo are described. However, recent work has shown that non-specific silencing effects and activation of the interferon response may occur following the use of some siRNA and delivery vector combinations. Future goals must therefore be to understand the mechanisms by which siRNA delivery leads to unwanted gene silencing effects in cells and, in this way, RNAi technology can reach its tremendous potential as a scientific tool and ultimately be used for therapeutic purposes.
On Neural Architecture Search for Resource-Constrained Hardware Platforms (2019)

In the recent past, the success of Neural Architecture Search (NAS) has enabled researchers to broadly explore the design space using learning-based methods. Apart from finding better neural network architectures, the idea of automation has also inspired to improve their implementations on hardware. While some practices of hardware machine-learning automation have achieved remarkable performance, the traditional design concept is still followed: a network architecture is first structured with excellent test accuracy, and then compressed and optimized to fit into a target platform. Such a design flow will easily lead to inferior local-optimal solutions. To address this problem, we propose a new framework to jointly explore the space of neural architecture, hardware implementation, and quantization. Our objective is to find a quantized architecture with the highest accuracy that is implementable on given hardware specifications. We employ FPGAs to implement and test our designs with limited loop-up tables (LUTs) and required throughput. Compared to the separate design/searching methods, our framework has demonstrated much better performance under strict specifications and generated designs of higher accuracy by 18\% to 68\% in the task of classifying CIFAR10 images. With 30,000 LUTs, a light-weight design is found to achieve 82.98\% accuracy and 1293 images/second throughput, compared to which, under the same constraints, the traditional method even fails to find a valid solution.
Efficient and Effective Schemes for Streaming Media Delivery (2005)

The rapid expansion of the Internet and the increasingly wide deployment of wireless networks provide opportunities to deliver streaming media content to users at anywhere, anytime. To ensure good user experience, it is important to battle adversary effects, such as delay, loss and jitter. In this thesis, we first study efficient loss recovery schemes, which require pure XOR operations. In particular, we propose a novel scheme capable of recovering up to 3 packet losses, and it has the lowest complexity among all known schemes. We also propose an efficient algorithm for array codes decoding, which achieves significant throughput gain and energy savings over conventional codes. We believe these schemes are applicable to streaming applications, especially in wireless environments. We then study quality adaptation schemes for client buffer management. Our control-theoretic approach results in an efficient online rate control algorithm with analytically tractable performance. Extensive experimental results show that three goals are achieved: fast startup, continuous playback in the face of severe congestion, and maximal quality and smoothness over the entire streaming session. The scheme is later extended to streaming with limited quality levels, which is then directly applicable to existing systems.
The rare outer membrane protein, OmpL1, of pathogenic Leptospira species is a heat-modifiable porin (1995)

The outer membranes of invasive spirochetes contain unusually small amounts of transmembrane proteins. Pathogenic Leptospira species produce a rare 31-kDa surface protein, OmpL1, which has a deduced amino acid sequence predictive of multiple transmembrane beta-strands. Studies were conducted to characterize the structure and function of this protein. Alkali, high-salt, and urea fractionation of leptospiral membranes demonstrated that OmpL1 is an integral membrane protein. The electrophoretic mobility of monomeric OmpL1 was modifiable by heat and reduction; complete denaturation of OmpL1 required prolonged boiling in sodium dodecyl sulfate (SDS), 8 M urea, and 2-mercaptoethanol. When solubilized in SDS at low temperature, a small proportion of OmpL1 exhibited an apparent molecular mass of approximately 90 kDa, indicating the existence of an SDS-unstable oligomer. OmpL1 dimers and trimers were demonstrated by nearest neighbor chemical cross-linking. In order to generate purified protein for functional studies, the ompL1 gene was ligated into the pMMB66 expression plasmid under control of the tac promoter. Although expression in Escherichia coli was toxic, most of the OmpL1 produced was found in the outer membrane, as determined by subcellular fractionation. Purified recombinant OmpL1 was reconstituted into planar lipid bilayers, demonstrating an average single channel conductance of 1.1 nS, similar to the major porin activity of native leptospiral membranes. These findings indicate that OmpL1 spans the leptospiral outer membrane and functions as a porin.