gebhart/patrepeval huggingface dataset:
Periodontal regeneration with enamel matriz derivative in one human experimental defect. A case report. (1997)

The purpose of the present study was to histologically assess the effect of enamel matrix derivative on periodontal regeneration in one human experimental defect. Experimental surgery was performed in a healthy male volunteer to create a buccal dehiscence defect in a mandibular incisor. Following bone removal and conditioning of the exposed root surface, enamel matrix derivative was applied onto the root surface. The flaps were then replaced and sutured. Clinical healing was uneventful. After 4 months, the experimental tooth together with the surrounding soft and hard tissues were removed surgically for histological evaluation. The microscopic examination revealed formation of a new acellular extrinsic fibre cementum, which was firmly attached to the underlying dentin. A new periodontal ligament with inserting and functionally-oriented collagen fibres and an associated alveolar bone was also present. The new cementum covered 73% of the original defect. Regain of bone was 65% of the presurgical bone height. It was concluded that adjunctive use of enamel matrix derivative could provide a regenerative technology with a potential for true periodontal regeneration.
Role of the Second and Third Intracellular Loops of Metabotropic Glutamate Receptors in Mediating Dual Signal Transduction Activation (1998)

On the basis of sequence homology and structural similarities, metabotropic glutamate receptors (mGluRs), extracellular Ca2+-sensing receptor, gamma-aminobutyric acid type B receptor, and pheromone receptors are enlisted in a distinct family within the larger G protein-coupled receptor superfamily. When expressed in heterologous systems, group I mGluRs can activate dual signal transduction pathways, phosphoinositides turnover and cAMP production. To investigate the structural basis of these coupling properties, we introduced single amino acid substitutions within the second and third intracellular loops (i2 and i3) of mGluR1alpha. Wild-type and mutant receptors were expressed in human embryonic kidney 293 cells and analyzed for their capacity to stimulate both signaling cascades. Each domain appeared to be critical for the coupling to phospholipase C and adenylyl cyclase. Within i2, Thr695, Lys697, and Ser702 were found to be selectively involved in the interaction with Gq class alpha subunit(s), whereas mutation of Pro698 and the deletion Cys694-Thr695 affected only Gs coupling. Furthermore, the mutation K690A profoundly altered mGluR1alpha signaling properties and imparted to the receptor the ability to couple to the inhibitory cAMP pathway. Within i3, we uncovered two residues, Arg775 and Phe781, that are crucial for coupling to both pathways, since their substitution leads to receptor inactivation.
Discovering denial constraints (2013)

Integrity constraints (ICs) provide a valuable tool for enforcing correct application semantics. However, designing ICs requires experts and time. Proposals for automatic discovery have been made for some formalisms, such as functional dependencies and their extension conditional functional dependencies. Unfortunately, these dependencies cannot express many common business rules. For example, an American citizen cannot have lower salary and higher tax rate than another citizen in the same state. In this paper, we tackle the challenges of discovering dependencies in a more expressive integrity constraint language, namely Denial Constraints (DCs). DCs are expressive enough to overcome the limits of previous languages and, at the same time, have enough structure to allow efficient discovery and application in several scenarios. We lay out theoretical and practical foundations for DCs, including a set of sound inference rules and a linear algorithm for implication testing. We then develop an efficient instance-driven DC discovery algorithm and propose a novel scoring function to rank DCs for user validation. Using real-world and synthetic datasets, we experimentally evaluate scalability and effectiveness of our solution.
Method for distributed transaction commit and recovery using Byzantine Agreement within clusters of processors (1983)

This paper describes an application of Byzantine Agreement [DoSt82a, DoSt82c, LyFF82] to distributed transaction commit. We replace the second phase of one of the commit algorithms of [MoLi83] with Byzantine Agreement, providing certain trade-offs and advantages at the time of commit and providing speed advantages at the time of recovery from failure. The present work differs from that presented in [DoSt82b] by increasing the scope (handling a general tree of processes, and multi-cluster transactions) and by providing an explicit set of recovery algorithms. We also provide a model for classifying failures that allows comparisons to be made among various proposed distributed commit algorithms. The context for our work is the Highly Available Systems project at the IBM San Jose Research Laboratory [AAFKM83].
DPSK Receiver Design - Optical Filtering Considerations (2007)

We study via simulation the influence of the DPSK decoder free spectral range (FSR) when strong optical filtering is considered for the NRZ and RZ modulation formats and show that larger FSR can improve performance.
Building Critical Applications Using Microservices (2016)

Safeguarding the correctness of critical software is a grand challenge. A microservice-based system is described that builds trustworthy systems on top of legacy hardware and software components, ensuring microservices' integrity, confidentiality, and correct execution with the help of secure enclaves.
Modelling of MOCVD Reactor: New 3D Approach (2014)

The paper presents comparison of two different 3D models of vertical, rotating disc MOCVD reactor used for 3D GaN structure growth. The first one is based on the reactor symmetry, while the second, novel one incorporates only single line of showerhead nozzles. It is shown that both of them can be applied interchangeably regarding the phenomena taking place within the processing area. Moreover, the importance of boundary conditions regarding proper modelling of showerhead cooling and the significance of thermal radiation on temperature field within the modelled structure are presented and analysed. The last phenomenon is erroneously neglected in most of the hitherto studies.
Review and Assessment of Radio-frequency and Microwave Energy for Stored-grain Insect Control (1996)

Fundamental principles of radio-frequency (RF) and microwave dielectric heating are presented, with a basic consideration of differential or selective absorption of energy from RF and microwave fields that might be applicable for stored-grain insect control. Experimental findings of the past 50 years are reviewed, with respect to entomological and physical factors affecting the response of insects exposed to RF and microwave electromagnetic fields in grain and grain products. Practical aspects of RF and microwave energy application for stored-grain insect control are considered, and it is concluded that such use is highly unlikely without some new discovery of a nonthermal lethal mechanism that might be exploited for this purpose.
Melting at dislocations and grain boundaries: A phase field crystal study (2008)

Dislocation and grain boundary melting are studied in three dimensions using the Phase Field Crystal method. Isolated dislocations are found to melt radially outward from their core, as the localized excess elastic energy drives a power law divergence in the melt radius. Dislocations within low-to-mid angle grain boundaries melt similarly until an angle-dependent first order wetting transition occurs when neighboring melted regions coalesce. High angle boundaries are treated within a screening approximation, and issues related to ensembles, metastability, and grain size are discussed.
A distributed registry for OpenURL Metadata Schemas with an OAI-PMH conformant central repository (2003)

This paper describes a distributed registry of XML Schemas in which a central facility uses the Open Archives Protocol for Metadata Harvesting (OAI-PMH) as a communication mechanism between registrars and parties that need to remain up-to-date regarding registration, updating and deregistration of those Schemas. This novel application of the OAI-PMH is described in the context of registration of XML Schema for usage in OpenURL applications. It suggests the applicability of the protocol in areas that go well beyond resource discovery, and that may actually reach into the realm of synchronization of administrative networked processes, and digital preservation.
Management of cluster headache. (2005)

Cluster headache, an excruciating, unilateral headache usually accompanied by conjunctival injection and lacrimation, can occur episodically or chronically, and can be difficult to treat. Existing effective treatments may be underused because of underdiagnosis of the syndrome. Oxygen and sumatriptan have been demonstrated to be effective in the acute treatment of cluster headaches. Verapamil has been shown to be effective for prophylaxis. For cluster headache completely refractory to all treatments, surgical modalities and newer interventions such as the implantation of stereotactic electrodes may be useful. Patients should be encouraged to avoid possible triggers such as smoking or alcohol consumption, especially during the duster period. The intensity of duster headache pain leads to ethical concerns among researchers over the use of placebo, making randomized controlled trials difficult. As new technology and genetic studies clarify the etiology of duster headache, it is possible that more specific therapies will emerge.
Differential enhancement of melphalan cytotoxicity in tumor and normal tissue by fluosol‐DA<sup>®</sup> and oxygen breathing (1985)

The addition of Fluosol-DA carbogen breathing to melphalan treatment of the FSa-IIC fibrosarcoma was assessed by tumor growth delay and cell survival assays. Melphalan (10 mg/kg) administered intraperitoneally (i.p.) was preceded by Fluosol-DA (0.3 ml) administered intravenously (i.v.) and followed by 1 hr of carbogen breathing; this resulted in a tumor growth delay of 9.5 +/- 1.4 days or an approximately 3-fold increase compared to melphalan alone. Melphalan produced about 1.7 logs of cell killing; neither carbogen breathing nor Fluosol-DA pretreatment altered the cell killing observed. There was a 10-fold increase in tumor-cell killing when Fluosol-DA was administered immediately prior to melphalan administration followed by carbogen breathing for 1 hr. Density gradient separation identified a population of denser FSa-IIC cells which showed increased sensitivity to melphalan after Fluosol-DA administration. There was no additional toxicity to bone marrow as measured by CFU-GM with the combination of melphalan/Fluosol-DA/O2 compared to melphalan alone.
A new general triangulation method for planar contours (1982)

The problem of approximating the surface spanning a given set of 3D points as a polyhedron of triangular faces (“triangulation”) is a significant one, and has many applications in the fields of computer graphics and computer vision. In this paper, several solutions to this problem are reviewed. These solutions can be grouped into two classes, and particular emphasis is given to the class of surfaces spanned by parallel planar contours. For a contour pair P 0 ,P 1 ,...P m−1 and Q 0 ,Q 1 ,...Q n−1 , a graph theoretic approach can be used to arrive at a class of solutions, each requiring exactly m+n steps to triangulate the pair. Existing methods (both rigorous and heuristic) for extracting a particular solution from this group are reviewed, and a new heuristic based on inter-contour coherence is proposed. This heuristic is being used in the field of Ultrasonic Non-destructive Evaluation to produce images of flaws in pressure vessels, and its performance is shown to compare favorably with methods of greater computational complexity. It is believed that this heuristic can also be used with success in industrial vision systems where similar contours are obtained using a laser range finder.
Advances in the role of sacral nerve neuromodulation in lower urinary tract symptoms (2010)

Sacral neuromodulation has been developed to treat chronic lower urinary tract symptoms, resistant to classical conservative therapy. The suspected mechanisms of action include afferent stimulation of the central nervous system and modulation of activity at the level of the brain. Typical neuromodulation is indicated both in overactivity and in underactivity of the lower urinary tract. In the majority of patients, a unilateral electrode in a sacral foramen and connected to a pulse generator is sufficient to achieve significant clinical results also on long term. In recent years, other urological indications have been explored.
Levetiracetam: A Practical Option for Seizure Management in Elderly Patients With Cognitive Impairment (2008)

Cognitive impairment and seizures are common in our aging population. Anticonvulsant treatment is problematic due to sedation, cognitive slowing, and behavioral changes. Levetiracetam has favorable pharmacokinetics, good efficacy in elderly individuals, a favorable side effect profile, and lacks major drug interactions. We conducted a prospective, uncontrolled, phase 4, open label, 12-week study of levetiracetam to better profile its efficacy, safety, and impact on cognitive/behavioral status in 24 cognitively impaired, elderly individuals. In total, 69% were seizure free for the duration of the study; the remaining participants had satisfactory seizure control. Fatigue was the most common side effect (5 participants). Significant overall improvements were observed for the Folstein's Mini-Mental State Examination and the Alzheimer's Disease Assessment Scale-Cognitive. No significant changes were seen in behavioral or functional measures. Levetiracetam is an effective antiepileptic drug in elderly individuals with cognitive impairment. At 3 months, participants who remained on levetiracetam showed excellent cognitive tolerability.
Multiplex PCR: Critical Parameters and Step-by-Step Protocol (1997)

By simultaneously amplifying more than one locus in the same reaction, multiplex PCR is becoming a rapid and convenient screening assay in both the clinical and the research laboratory. While numerous papers and manuals discuss in detail conditions influencing the quality of PCR in general, relatively little has been published about the important experimental factors and the common difficulties frequently encountered with multiplex PCR. We have examined various conditions of the multiplex PCR, using a large number of primer pairs. Especially important for a successful multiplex PCR assay are the relative concentrations of the primers at the various loci, the concentration of the PCR buffer, the cycling temperatures and the balance between the magnesium chloride and deoxynucleotide concentrations. Based on our experience, we propose a protocol for developing a multiplex PCR assay and suggest ways to overcome commonly encountered problems.
Platelet-Derived 12-Hydroxyeicosatetraenoic Acid Plays an Important Role in Mediating Canine Coronary Thrombosis by Regulating Platelet Glycoprotein IIb/IIIa Activation (1998)

OPC-29030 reduced intraplatelet 12-HETE levels, resulting in the inhibition of coronary thrombosis in vivo in dogs. OPC-29030 inhibited human platelet glycoprotein IIb/IIIa activation in vitro. Thus, platelet-derived 12-HETE may play an important role in mediating thrombotic process.
Ranking and Clustering Web Services Using Multicriteria Dominance Relationships (2010)

As the web is increasingly used not only to find answers to specific information needs but also to carry out various tasks, enhancing the capabilities of current web search engines with effective and efficient techniques for web service retrieval and selection becomes an important issue. Existing service matchmakers typically determine the relevance between a web service advertisement and a service request by computing an overall score that aggregates individual matching scores among the various parameters in their descriptions. Two main drawbacks characterize such approaches. First, there is no single matching criterion that is optimal for determining the similarity between parameters. Instead, there are numerous approaches ranging from Information Retrieval similarity measures up to semantic logic-based inference rules. Second, the reduction of individual scores to an overall similarity leads to significant information loss. Determining appropriate weights for these intermediate scores requires knowledge of user preferences, which is often not possible or easy to acquire. Instead, using a typical aggregation function, such as the average or the minimum of the degrees of match across the service parameters, introduces undesired bias, which often reduces the accuracy of the retrieval process. Consequently, several services, e.g., those having a single unmatched parameter, may be excluded from the result set, while being potentially good candidates. In this work, we present two complementary approaches that overcome the aforementioned deficiencies. First, we propose a methodology for ranking the relevant services for a given request, introducing objective measures based on dominance relationships defined among the services. Second, we investigate methods for clustering the relevant services in a way that reveals and reflects the different trade-offs between the matched parameters. We demonstrate the effectiveness and the efficiency of our proposed techniques and algorithms through extensive experimental evaluation on both real requests and relevance sets, as well as on synthetic scenarios.
Accelerometer and GPS sensor combination based system for human activity recognition (2013)

Mobile phone technology continuously evolves and incorporates more and more sensors for enabling advanced applications. The availability of these sensors in mass-market communication devices creates exciting new opportunities for data mining applications. Particularly healthcare applications exploiting build-in sensors are very promising. These devices open wide range of opportunities of using their potential in different branches like healthcare, financing and so on. Current paper introduces an approach which allows recognizing activity, performed by human, using smartphone acceleration and positioning sensors. We introduce an approach that retrieves signal data and stores it SQLite portable mobile database. It uses asynchronous model of signal retrieving and storing procedures. After the signals were collected we applied noise reduction, time and frequency domain feature extraction processes for stored information and acquired high-dimensional feature patterns. These patterns were later transferred on remote server instead of raw signals. The classification stage was based on “learning with teacher” method. Incoming signal sequences were collected from sensors of mobile device and were analyzed using support vector machines (SVM) learning method.
Stabilizing high-period orbits in a chaotic system: The diode resonator (1991)

The chaotic dynamics found in the diode resonator has been converted into stable orbits with periods up to 23 drive cycles long. The method used is a modification of that of Ott, Grebogi, and Yorke [Phys. Rev. Lett. 64, 1196 (1990)]. In addition to stabilizing existing low-period orbits, the method allows making small alterations in the attractor permitting previously nonexistent periodic orbits to be stabilized. It is an analog technique and therefore can be very fast, making it applicable to a wide variety of systems.
Cyclic AMP-dependent protein kinase is involved in morphogenesis of Aspergillus niger a aThe EMBL accession number for the sequence reported in this paper is AJ296317. (2002)

The cAMP signal transduction pathway controls many processes in fungi. The pkaR gene, encoding the regulatory subunit (PKA-R) of cAMP-dependent protein kinase (PKA), was cloned from the industrially important filamentous fungus Aspergillus niger. To investigate the involvement of PKA in morphology of A. niger, a set of transformants which overexpressed pkaR or pkaC (encoding the catalytic subunit of PKA) either individually or simultaneously was prepared as well as mutants in which pkaR and/or pkaC were disrupted. Strains overexpressing pkaR or both pkaC and pkaR could not be distinguished from the wild-type, suggesting that regulation of PKA activity is normal in these strains. Absence of PKA activity resulted in a two- to threefold reduction in colony diameter on plates. The most severe phenotype was observed in the absence of PKA-R, i.e., very small colonies on plates, absence of sporulation and complete loss of growth polarity during submerged growth. Suppressor mutations easily developed in the DeltapkaR mutant and one of these mutants appeared to lack PKA-C activity. These data suggest that cAMP-dependent protein phosphorylation in A. niger regulates growth polarity and formation of conidiospores.
The SBus: Sun's high performance system bus for RISC workstations (2002)

An overview of the design of SBus, Sun's SPARCstation 1 memory and input/output (I/O) expansion bus, is presented. In creating the SBus, the foremost goal was that overall system performance should not suffer because of the SBus design. The next most important goal was that I/O devices, including Ethernet and FDDI, be able to rely on the same high-performance, low-latency access to memory that is available to the central processor. Another goal was that it is possible to implement the interface between an I/O device and the SBus in a low-cost CMOS gate array, without having to use external buffers or drivers. A final goal was for the SBus to be the interface for I/O expansion. Raw SBus performance is provided by allowing a system clock of up to 25 MHz, represents a nice balance between ultimate performance and ease of system design and integration when boards are built by different manufacturers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Vaccine Development for Hepatitis C (2000)

Given the global disease burden and public health impact of hepatitis C, the development of an effective vaccine is of paramount importance. However, many challenging obstacles loom ahead of this goal. The hepatitis C virus (HCV), being an RNA virus, can mutate rapidly in adaptation to the environment, thus contributing to the high sequence divergence of multiple viral isolates in the world. The highest heterogeneity has been found in the hypervariable region of the envelope glycoprotein 2, which contains a principal neutralization epitope. HCV also causes persistent infection in a high percentage of immunocompetent hosts despite active immune response. The lack of an efficient tissue culture system for propagating HCV and testing neutralizing antibodies adds further complexity to the task of vaccine development. The immunologic correlates associated with disease progression or protection are yet to be defined, but recent studies suggest that a vigorous multispecific cellular immune response is important in the resolution of infection. Induction of high-titer, long-lasting, and cross-reactive antienvelope antibodies and a vigorous multispecific cellular immune response that includes both helper and cytotoxic T lymphocytes may be necessary for an effective vaccine. Several promising approaches have been used to develop an HCV vaccine. Novel vaccine candidates based on molecular technology such as recombinant proteins, peptides, viruslike particles, naked DNA, and recombinant viruses are being explored. The final vaccine product may require multiple components that target various aspects of protective immunity. Finally, sterilizing immunity may not be necessary if a vaccine can be developed to prevent chronic infection, which is the major cause of morbidity and mortality from this disease.