gebhart/patrepeval huggingface dataset:
Signal processing in an optical polarization diversity receiver for 560-Mbit/s ASK heterodyne detection (1989)

Polarization diversity is an alternative technique for coherent receivers to prevent loss to signal due to variations in the states of polarization (SOP) of the received signal field. It is shown experimentally and theoretically that there is no significant power penalty difference between a receiver with optimally adjusted gains and receivers with linear envelope detection and square-law detection. Experimentally, two amplitude-shift keying (ASK) heterodyne polarization diversity receivers with envelope detectors were demonstrated at 560 Mb/s, one using linear rectifiers, the other using square-law rectifiers. In both cases, the receiver sensitivity of -35 dBm at BER=10/sup -9/ was degraded by less than 1 dB as the received signal SOP was varied, in agreement with theory.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Preparation and determination of X-ray-crystal and NMR-solution structures of γ2,3,4-peptides (2001)

(R,R,R)-γ-Amino acids with side chains in the 2-, 3-, and 4-positions, prepared by addition of acyloxazolidinones to a nitroolefin and hydrogenation, have been coupled to γ- tetra-, and γ-hexapeptides which are shown to form (M)-2.614 helices in the crystal state and in MeOH solution.
Biofibres, biodegradable polymers and biocomposites: An overview (2000)

Recently the critical discussion about the preservation of natural resources and recycling has led to the renewed interest concerning biomaterials with the focus on renewable raw materials. Because of increasing environmental consciousness and demands of legislative authorities, use and removal of traditional composite structures, usually made of glass, carbon or aramid fibers being reinforced with epoxy, unsaturated polyester, or phenolics, are considered critically. Recent advances in natural fiber development, genetic engineering and composite science offer significant opportunities for improved materials from renewable resources with enhanced support for global sustainability. The important feature of composite materials is that they can be designed and tailored to meet different requirements. Since natural fibers are cheap and biodegradable, the biodegradable composites from biofibers and biodegradable polymers will render a contribution in the 21st century due to serious environmental problem. Biodegradable polymers have offered scientists a possible solution to waste-disposal problems associated with traditional petroleum-derived plastics. For scientists the real challenge lies in finding applications which would consume sufficiently large quantities of these materials to lead price reduction, allowing biodegradable polymers to compete economically in the market. Today's much better performance of traditional plastics are the outcome of continued R&D efforts of last several years; however the existing biodegradable polymers came to public only few years back. Prices of biodegradable polymers can be reduced on mass scale production; and such mass scale production will be feasible through constant R&D efforts of scientists to improve the performance of biodegradable plastics. Manufacture of biodegradable composites from such biodegradable plastics will enhance the demand of such materials. The structural aspects and properties of several biofibers and biodegradable polymers, recent developments of different biodegradable polymers and biocomposites are discussed in this review article. Collaborative R&D efforts among material scientists and engineers as well as intensive co-operation and co-ordination among industries, research institutions and government are essential to find various commercial applications of biocomposites even beyond to our imagination.
Dementia and Alzheimer Disease Incidence (2002)

Our dementia and AD incidence rates are consistent with recent US and European cohort studies, providing clinicians and researchers new information concerning the reproducibility of incidence estimates across settings. Increased risk was associated with age and the apolipoprotein E genotype; also with a low baseline cognitive screening test score. Educational level was inversely associated with the risk of dementia and positively associated with the baseline cognitive test score; thus, detection of AD by the screening test could also be influenced by educational level.
Expression and regulation of Ly-6 differentiation antigens by murine osteoblasts (1994)

Osteoblasts arise from mesenchymal stem cells and differentiate to become osteoid-secreting cells. However, little is known about these cells during their stages of differentiation. One reason for this lack of information is that there is no reliable method to identify osteoblasts as they mature. One method that has been used successfully with other cell types is the identification of plasma membrane-expressed differentiation antigens. The Ly-6 multigene family encodes differentiation antigens originally detected on lymphoid cells. Primary murine osteoblasts and the osteoblast-like MC3T3 cell line were examined for expression of Ly-6 antigens by flow cytometry. Primary osteoblasts and MC3T3 cells constitutively expressed both Ly-6A and Ly-6C antigens, although Ly-6C was much less abundant. Antigen expression was markedly increased by pretreating the cells with interferon-alpha/beta or -gamma. Northern blot analysis revealed constitutively expression of Ly-6 messenger RNA that was up-regulated by interferon treatment. Pretreatment of the cells with transforming growth factor-beta 1 or 1,25-dihydroxyvitamin D3 diminished constitutive Ly-6 expression. Ly-6 was localized intracellularly to the Golgi complex. The current results demonstrate that mature osteoblasts express on their cell surface specific Ly-6 antigens in a pattern that distinguishes them from the surrounding bone marrow cells. These studies represent the first identification of osteoblast differentiation antigens that can be directly related to cells within the hematopoietic lineage. By identifying similar antigens, osteoblasts at various stages of differentiation may be identified, isolated, and characterized.
Identification of the dialysable serum inducer of germ-tube formation in Candida albicans (2004)

Yeast cells of Candida albicans are induced by serum at 37 degrees C to produce germ tubes, the first step in a transition from yeast to hyphal growth. Previously, it has been shown that the active component is not serum albumin but is present in the dialysable fraction of serum. In this study, serum induction of germ-tube formation is shown to occur even in the presence of added exogenous nitrogen sources and is therefore not signalled by nitrogen derepression. The active component in serum was purified by ion-exchange, reverse-phase and size-exclusion chromatography from the dialysable fraction of serum and was identified by NMR to be d-glucose. Enzymic destruction of glucose, using glucose oxidase, demonstrated that d-glucose was the only active component in these fractions. Induction of germ-tube formation by d-glucose required a temperature of 37 degrees C and the pH optimum was between pH 7.0 and 8.0. d-Glucose induced germ-tube formation in a panel of clinical isolates of C. albicans. Although d-glucose is the major inducer in serum, a second non-dialysable, trichloroacetic acid precipitable inducer is also present. However, whereas either 1.4 % (v/v) serum or an equivalent concentration of d-glucose induced 50 % germ-tube formation, the non-dialysable component required a 10-fold higher concentration to induce 50 % germ-tube formation. Serum is, therefore, the most effective induction medium for germ-tube formation because it is buffered at about pH 8.5 and contains two distinct inducers (glucose and a non-dialysable component), both active at this pH.
Electro-osmotic capture and ionic discrimination of peptide and protein biomarkers with FraC nanopores (2017)

Biological nanopores are nanoscale sensors employed for high-throughput, low-cost, and long read-length DNA sequencing applications. The analysis and sequencing of proteins, however, is complicated by their folded structure and non-uniform charge. Here we show that an electro-osmotic flow through Fragaceatoxin C (FraC) nanopores can be engineered to allow the entry of polypeptides at a fixed potential regardless of the charge composition of the polypeptide. We further use the nanopore currents to discriminate peptide and protein biomarkers from 25 kDa down to 1.3 kDa including polypeptides differing by one amino acid. On the road to nanopore proteomics, our findings represent a rationale for amino-acid analysis of folded and unfolded polypeptides with nanopores.Biological nanopore-based protein sequencing and recognition is challenging due to the folded structure or non-uniform charge of peptides. Here the authors show that engineered FraC nanopores can overcome these problems and recognize biomarkers in the form of oligopeptides, polypeptides and folded proteins.
OPERATION OF A LARGE SCALE, GENERAL PURPOSE WIKI WEBSITE (2002)

A Wiki website is a hypertext on steroids. Any user can create or edit any page on the site using a simple web browser, and all information processing is done on the server side. Wiki sites are powerful tools for collaboration in closed work groups, but can also be used for the general public on the open Internet. This paper summarizes the experience from the first nine months of operation of Sweden’s biggest Wiki website susning.nu, including its usefulness in non-profit and commercial applications, in hobby and professional, projects, its social and legal aspects, its relation to geographic information systems, subject information gateways, the establishment of a controlled vocabulary, and its implications on learning, free speech, the price of information, licensing, and copyright. Relevant comparisons to similar projects in other countries are also presented.
Second-Line Therapy in Refractory Pancreatic Cancer. Results of a Phase II Study (2009)

Background: This phase II trial investigated the efficacy and safety of oxaliplatin (O), 5-fluorouracil (5-FU), and folinic acid (FA) (OFF) as second-line treatment for patients with metastatic pancreatic adenocarcinoma after failure of first-line gemcitabine treatment. Patients and Methods: 37 patients with confirmed progressive disease on gemcitabine therapy were treated with OFF (O 85 mg/m2 days 8, 22; FA 500 mg/m2, followed by 5-FU 2,600mg/m2 days 1, 8, 15, 22) every 6 weeks. Patients were treated on an outpatient basis and remained on treatment until disease progression. Results: All patients were assessable for toxicity and effectiveness. We observed moderate hematotoxicity, the most common non-hematologic toxicity was neurotoxicity. A total of 12 patients had grade 3 nonhematologic toxicities: nausea and vomiting (4 patients), reversible neurotoxicity (5 patients), and diarrhea (3 patients). No grade 4 toxicities were observed. Median time to progression was 12 (1–125) weeks. Survival in second line was 22 (4–326+) weeks. Overall disease control rate was 49% (complete remission = 3%; partial remission = 3%; stable disease > 12 weeks = 43%). Conclusions: This regimen is feasible and active with an acceptable toxicity profile; it can be safely administered in an outpatient setting. There is an urgent need for further investigation in phase III trials.
Multifocal motor neuropathy improved by IVIg (2000)

IVIg improved conduction block as well as subjective and objective clinical measures of function in patients with MMN.
High-speed pressure sensor grid for humanoid robot foot (2005)

This paper describes a 32 /spl times/ 32 matrix scan type high-speed pressure sensor for the feet of humanoid robots that has 1 kHz sampling rate. This sensor has matrix scan circuit. The matrix scan method has a problem of interference by bypass current. To resolve this problem, we suggest a novel method using a very thin conductive rubber. We adopted a very thin (0.6 mm) force sensing conductive rubber sheet for high speed sensing. Each sensing area is 4.2 /spl times/ 7.0 mm and can measure vertical force of approximately 0.25-20 N. Walking cycle of humanoid robot as well as human being is about 0.4-0.8 s and dual leg phase is about 0.1-0.15 s. The target of the sensor is biped walk stabilization so that high-speed input is important. Matrix scan type circuit is connected to sensor, and the system runs 1 kHz with 14 bit resolution at 4.2 /spl times/ 7.0 mm grid for 32 /spl times/ 32 points, and the sensor size is the same as humanoid robot foot 135 /spl times/ 228 mm, The system is running high-speed because of the very thin conductive rubber and simultaneous measurement. The sensor system, a novel scan method, and evaluation results are described.
Characteristics of a <i>Streptomyces coelicolor</i> A3(2) Extracellular Protein Targeting Chitin and Chitosan (2001)

ABSTRACT Upstream of the Streptomyces coelicolor A3(2) chitinase G gene, a small gene (named chb3 ) is located whose deduced product shares 37% identical amino acids with the previously described CHB1 protein from Streptomyces olivaceoviridis . The chb3 gene and its upstream region were cloned in a multicopy vector and transformed into the plasmid-free Streptomyces lividans TK21 strain. The CHB3 protein (14.9 kDa) was secreted by the S. lividans TK21 transformant during growth in the presence of glucose, N -acetylglucosamine, yeast extract, and chitin. The protein was purified to homogeneity using anionic exchange, hydrophobic interaction chromatographies, and gel filtration. In contrast to CHB1, CHB3 targets α-chitin, β-chitin, and chitosan at pH 6.0 but does so relatively loosely. The ecological implications of the divergence of substrate specificity of various types of chitin-binding proteins are described.
&lt;title&gt;Ladar fiber optic sensor system for aircraft applications&lt;/title&gt; (1993)

A ladar fiber optic sensor (LFOS) for aircraft applications is described. Chirped intensity- modulated ranging is used to estimate linear position. LFOS technology offers several advantages over other fiber optic sensor techniques proposed for aircraft position sensing applications, including small and robust transducer heads, inherent multiplexing capability, and inherent fault isolation capability. LFOS sensors have been integrated inside a flight control surface hydraulic actuator and inside a pilot's sidestick controller. Closed loop operation of the actuator using the LFOS sensor for position feedback was successfully demonstrated in the laboratory. The LFOS sensors in the sidestick controller were used as inputs to fly a flight simulator. The current LFOS interface electronics is contained on two VME circuit cards, with the capability to service four multiplexed sensors. Excellent performance has been achieved. Deviation from linearity over a 7-in. stroke is better than 0.05% of full scale. The RMS measurement noise is less than 15 microns for a 1 millisecond measurement interval.
Sequence Selectivity of c-Myb in Vivo (1999)

We have investigated the basis for the striking difference between the broad DNA sequence selectivity of the c-Myb transcription factor minimal DNA-binding domain R(2)R(3) in vitro and the more restricted preference of a R(2)R(3)VP16 protein for Myb-specific recognition elements (MREs) in a Saccharomyces cerevisiae transactivation system. We show that sequence discrimination in yeast is highly dependent on the expression level of Myb effector protein. Full-length c-Myb and a C-terminally truncated protein (residues 1-360) were also included in the study. All of the tested Myb proteins displayed very similar DNA binding properties in electrophoretic mobility shift assays. Only minor differences between full-length c-Myb and truncated c-Myb(1-360) were observed. In transactivation studies in CV-1 cells, the MRE selectivity was highest at low expression levels of Myb effector proteins. However, the discrimination between MRE variants was rapidly lost with high input levels of effector plasmid. In c-Myb-expressing K-562 cells, the high degree of MRE selectivity was retained, thereby confirming the relevance of the results obtained in the yeast system. These data suggest that the MRE selectivity of c-Myb is an intrinsic property of only the R(2)R(3) domain itself and that the transactivation response of a specific MRE in vivo may be highly dependent on the expression level of the Myb protein in the cell.
Robust Direct-Write Dispensing Tool and Solutions for Micro/Meso-Scale Manufacturing and Packaging (2007)

The development of functional and reliable miniaturized devices including Micro Electro Mechanical Systems (MEMS) has stressed the manufacturing and packaging processes. The traditional micro fabrication techniques, such as lithography, physical vapor deposition (PVD), chemical vapor deposition (CVD) and etching, are layer-by-layer processes and mostly suitable for thin-filmed devices. LIGA (an acronym from German words for lithography, electroplating, and molding) is a newly developed process for thick metallic devices; however, it involves electroplating process and high quality molds, which are hard to move after electroforming. In all the processes mentioned above, masks and photoresist processing are inevitable, which complicates the whole process and increases the processing time and the total cost. It is also well known that packaging is another barrier for the advancement of MEMS. MEMS packaging, which is required to provide mechanical support, environmental protection and electrical connection to other system components, is much more complicated as compared to electronic components due to the moving structures, fluids or chemicals involved. It is the most expensive process in micromachining. Therefore, enabling tools and technologies are greatly needed for the fabrication and packaging of complicated devices and highly integrated micro assemblies. In this paper, we will present novel direct-print dispensing techniques and robust tools for 21st century manufacturing and packaging. Comparing to other dispensing technologies such as time-pressure needle dispensing, screen printing, pin transfer and jetting, nScrypt’s pumping techniques can dispense materials with precise volume control for 10’s of Pico liter resolution, accurate placement or alignment within a few microns, conformably print on exaggerated surfaces of 10’s of centimeters, and are extremely flexible with materials and patterns. The dispensing tip (nozzle) is optimized to reduce the pressure drop as compared to the traditional tubing needles. Comparing to traditional micro fabrication technologies, our direct-print dispensing technology is maskless and thus a cost effective process. While micro-dispensing is a solution based approach, it has the advantage of not being a wet process such as wet etching or electroplating. Direct-print dispensing of micro lines, micro dots, and three-dimensional structures will be presented. The technology has a wide range of applications in the manufacturing and packaging of micro/meso-scale devices and bio structures.
An Adaptive Dynamic Replacement Approach for a Multicast based Popularity Aware Prefix Cache Memory System (2010)

In this paper we have proposed an adaptive dynamic cache replacement algorithm for a multimedia servers cache system. The goal is to achieve an effective utilization of the cache memory which stores the prefix of popular videos. A replacement policy is usually evaluated using hit ratio, the frequency with which any video is requested. Usually discarding the least recently used page is the policy of choice in cache management. The adaptive dynamic replacement approach for prefix cache is a self tuning, low overhead algorithm that responds online to changing access patterns. It constantly balances between lru and lfu to improve combined result. It automatically adapts to evolving workloads. Since in our algorithm we have considered a prefix caching with multicast transmission of popular objects it utilizes the hard disk and network bandwidth efficiently and increases the number of requests being served.
Factors influencing localization of labeled antibodies in tumors. (1980)

Recent success with antibody to carcinoembryonic antigen makes it desirable to survey the practicality of producing other tumor-localizing antibodies for diagnosis and therapy. General procedures for reaching these goals are outlined. Experimental animal studies show some progress; detecting moderate-sized tumors by scanning appears a reasonable goal, but there is a basic lack of knowledge regarding the extent to which tumors express tumor-specific or associated antigens in vivo. This makes it difficult to evaluate the probability for success of different therapeutic proposals now under study. For organs not vital for the life and well-being of the patient, organ-specific antigens expressed on tumor may offer a target for immunological attack. Techniques for cloning antibody-producing cells promise more uniform and specific antibody preparations.
Polymer microchips bonded by O2-plasma activation (2002)

This paper presents a fabrication of polymer microchips with homogeneous material technique due to surface treatment by plasma before sealing. UV laser photoablation was used for fast prototyping of microstructures, and oxygen plasma was used as a surface treatment for both the microfabricated substrate and the polymer cover. It was found that with an oxidative plasma treatment, successful bonding could be achieved without adhesive material between polymer sheets substantially below the glass transition temperature of the polymer. Homogeneous polyethylene terephthalate (PET) microstructures were characterized by scanning electron microscopy (SEM) and analyzed by X-ray photoelectron spectroscopy (XPS) surface analyses after different surface treatments. The electroosmotic flow characteristics including the velocity and the stability over 20 days have been tested and compared to composite channels, in which the cover presents a polyethylene (PE) adhesive layer. Capillary zone electrophoresis in both homogeneous and composite microanalytical devices were then performed and compared in order to evaluate the separation efficiency. In preliminary experiments, a plate height of 0.6 microm has been obtained with homogenous microchannels. The surface analysis pointed out that the surface chemistry is of prime importance for the performance of microfluidic separation.
Channeling Franz Marc in the Prelapsarian Longing of Joan Jonas and Lee Lennox (2015)

This paper uses aspects of the type of Nachträglichkeit, or deferred action, as described by Hal Foster in "The Return of the Real" (1996) to recover Franz Marc's utopian visions of Eden as shown in the mural Marc made with August Macke called "Paradies". Traces of Marc's ideas about animals and utopia can be found in Joan Jonas's 2009 "Reading Dante," an installation from the 2009 Biennale di Venezia, and in the video "Girl and the Sea," directed by Lee Lennox to accompany the 2004 song of the same name by the Presets.
Anti-Nogo-A antibody treatment does not prevent cell body shrinkage in the motor cortex in adult monkeys subjected to unilateral cervical cord lesion (2008)

The anti-Nogo-A antibody treatment did not preserve the axotomized CS cells from soma shrinkage, indicating that the anti-Nogo-A antibody treatment affects morphologically the axotomized CS neurons mainly at distal levels, especially the axon collateralization in the cervical cord, and little or not at all at the level of their soma.
Light whole genome sequence for SNP discovery across domestic cat breeds (2010)

These data provide a large collection of mapped feline SNPs across the cat genome that will allow for the development of SNP genotyping platforms for mapping feline diseases.