gebhart/patrepeval huggingface dataset:
Electromagnetic energy exposure of simulated users of portable cellular telephones (1995)

Describes a method to quantify the RF exposure of the users of portable cellular phones in terms of specific absorption rate (SAR). The method involves a robotic system to accurately position an isotropic E-field probe within equivalent biological tissue. The user of cellular phones is simulated by a simple human model (a phantom) consisting of a thin shell of fibreglass filled with a liquid having the complex dielectric constant of human brain tissue. The authors present the results of the dosimetric assays conducted using current and previous models of cellular telephones. The peak SAR values detected using the measurement method described are below the limits recommended by the National Council for Radiation Protection and Measurements (NCRP) Report 86 for the protection of humans exposed to RF electromagnetic energy.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Designing optical sensor arrays with enhanced sensitivity for explosives detection (1998)

We have previously developed an optically-based 'artificial nose' to detect a wide variety of volatile organic compounds. An optical fiber sensor array is prepared containing a variety of differentially-reactive sensors comprised of polymer/dye combinations. When an analyte is presented in pulsatile form each sensor produces a unique fluorescence vs. time signature. The system employs neural network analysis to discriminate between many organic vapors using pattern recognition. Following an initial training step, the system can recognize 91 - 100% of a training set and greater than 84% of a test set of volatile organics. We are now attempting to detect explosives and explosive-like materials using this system. Prior work has shown that some sensors respond to compounds structurally similar to TNT (e.g. 2,4-DNT and 2,6-DNT) at saturated vapor concentrations. These preliminary results provide grounds for exploring the capacity of these and other new polymer/dye sensing combinations for detecting polynitro- compounds at low concentrations.
Emerging Therapies in Narcolepsy-Cataplexy (2005)

In the past, narcolepsy was primarily treated using amphetamine-like stimulants and tricyclic antidepressants. Newer and novel agents, such as the wake-promoting compound modafinil and more selective reuptake inhibitors targeting the adrenergic, dopaminergic, and/or serotoninergic reuptake sites (ie, venlafaxine, atomoxetine) are better-tolerated available alternatives. The development of these agents, together with sodium oxybate (a slow-wave sleep-enhancing agent that consolidates nocturnal sleep, reduces cataplexy, and improves sleepiness), has led to improved functioning and quality of life for many patients with the disorder. However, these treatments are all symptomatically based and do not target hypocretin, a major neurotransmitter involved in the pathophysiology of narcolepsy. In this review, we discuss emerging therapies in the area of narcolepsy. These include novel antidepressant or anticataplectic, wake-promoting, and hypnotic compounds. We also report on novel strategies designed to compensate for hypocretin deficiency and on the use of immunosupression at the time of narcolepsy onset.
Thymidine kinase and thymidylate synthase in advanced breast cancer: response to tamoxifen and chemotherapy. (2001)

Thymidylate synthase (TS) is a crucial target for 5-fluorouracil (5-FU) in the de novo pathway of pyrimidine synthesis, which is necessary for DNA synthesis. Thymidine kinase (TK) plays a key role in the complementary or alternative salvage pathway of pyrimidine synthesis in acute or pathological tissue stress. In the present study, the activity levels of TS and TK were determined in 257 primary breast tumors of patients who received tamoxifen as first-line systemic therapy after diagnosis of advanced disease. In 155 (60%) responding patients, the median response duration was 23 months for tumors with low TK activity, 15 months for tumors with intermediate TK activity, and 13 months for tumors with high TK activity (P = 0.003). In Cox multivariate analysis corrected for classical predictive factors including estrogen receptor and progesterone receptor, patients with intermediate and high levels of TK activity in their tumors showed a rapid disease progression (P = 0.0002) and an early death (P = 0.002) after start of tamoxifen treatment. Tumor TS activity levels were not significantly associated with the efficacy of tamoxifen treatment. In 121 patients who became resistant to tamoxifen or additional endocrine treatments and who received 5-FU-containing polychemotherapy, tumor TK activity was not significantly related to the efficacy of chemotherapy. Of the 13 patients with low tumor TS activity, only 1 (8%) responded favorably, whereas 46% (43 of 93) of those with intermediate and 73% (11 of 15) of those with high TS activity responded (P = 0.001). In Cox multivariate regression analysis in which TS was the only significant variable, intermediate and high TS activities were associated with a slow disease progression (P = 0.005) and prolonged survival (P = 0.016) on chemotherapy. In conclusion, for patients with recurrent breast cancer, high tumor TK activity is a significant marker of poor clinical outcome on tamoxifen therapy. Elevated tumor TS activity predicts a favorable outcome for 5-FU-containing polychemotherapy when applied after tumor progression on endocrine therapy.
The novel brain neuropeptide, orexin‐A, modulates the sleep–wake cycle of rats (2000)

Orexin-A is a novel neuropeptide initially isolated from hypothalamic extracts but now known to be present in fibres distributed throughout the rat CNS including many regions associated with sleep-wake regulation. The recognition of a particularly dense innervation of orexinergic nerves in the locus coeruleus, together with the observed increase in firing rate of locus coeruleus neurons following application of orexin-A in vitro, further highlighted a potential involvement of the peptide in modulating the arousal state. The present study was undertaken to determine the effects of intracerebroventricularly (ICV) administered orexin-A on the sleep-wake cycle of conscious rats using electroencephalographic and electromyographic recordings. When administered at the onset of the normal sleep period, orexin-A (1, 10 or 30 microg/rat ICV) produced a dose-dependent increase in the time rats spent awake during the second and third hours after dosing. The enhancement of arousal was accompanied by a marked reduction in paradoxical sleep and deep slow wave sleep at the highest dose. The latency to the first occurrence of paradoxical sleep was also prolonged. This overall profile of increased arousal and decreased paradoxical sleep is consistent with a high rate of firing of locus coeruleus neurons as would be expected to occur following ICV administration of orexin-A. It is concluded that orexin-A may play an important physiological role in regulating the sleep-wake state, a hypothesis considerably strengthened by the recently reported narcoleptic phenotype of prepro-orexin (the precursor for orexin-A) knockout mice.
Iterative decoding and channel estimation for space-time bicm over mimo block fading multipath awgn channel (2003)

In this paper, we consider a generic model of space-time bit-interleaved coded modulation (ST-BICM) on a multiple-input multiple-output (MIMO) Rayleigh fading multipath channel. A practical low-complexity receiver structure performing iteratively MIMO data detection, channel decoding and channel estimation, is presented. The MIMO data detection, employing a reduced-state list-type soft output Viterbi algorithm enables to cope with severe channel intersymbol interference (ISI) without MIMO prefiltering. Among other results, simulations show that our approach can dramatically improve the downlink performance of time-division multiple access (TDMA) systems with high order modulation, keeping a reasonable complexity at the receiver side.
Prevention of posterior capsule opacification by intraoperative single-dose pharmacologic agents (2001)

Intraoperative single-dose application of EDTA, EDTA+RGD peptide combination, and MMC significantly prevented the development of PCO in rabbit eyes. Diclofenac was less effective but also reduced PCO. Although dexamethasone did not prevent the proliferation of LECs, it decreased PCO clinically.
CHAUNCY HARRIS AND EDWARD ULLMAN, “THE NATURE OF CITIES”: A FIFTIETH YEAR COMMEMORATION (1997)

(1997). CHAUNCY HARRIS AND EDWARD ULLMAN, “THE NATURE OF CITIES”: A FIFTIETH YEAR COMMEMORATION. Urban Geography: Vol. 18, Chauncy Harris and Edward Ullman, 'The Nature of Cities': A Fiftieth Year Commemoration, pp. 1-3.
Ethics Consultation in United States Hospitals: A National Survey (2007)

The response rate was 87.4%. Ethics consultation services (ECSs) were found in 81% of all general hospitals in the U.S., and in 100% of hospitals with more than 400 beds. The median number of consults performed by ECSs in the year prior to survey was 3. Most individuals performing ethics consultation were physicians (34%), nurses (31%), social workers (11%), or chaplains (10%). Only 41% had formal supervised training in ethics consultation. Consultation practices varied widely both within and between ECSs. For example, 65% of ECSs always made recommendations, whereas 6% never did. These findings highlight a need to clarify standards for ethics consultation practices.
Clean Synthesis in Ionic liquids (2002)

Ionic liquids can be used for clean synthesis in a variety of chemical reactions. Presented here is a review of chemical reactions that can be carried out in ionic liquids. Although this is not a comprehensive review, emphasis has been placed presenting reactions that allow the ionic liquids employed, to be recycled and reused. Also, chemical reactions where the use of ionic liquids presents some advantage over the reactions carried out in "conventional solvents" are also exemplified.
Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1 alpha. (1988)

In rheumatoid arthritis there is a chronic immune and inflammatory reaction which can lead to the destruction of the diseased joint. Cytokine gene expression was studied in synovial cells using cDNA probes specific for human interleukin 1 (IL-1), -alpha and IL-1 beta, tumour necrosis factor (TNF), -alpha and TNF beta (lymphotoxin); protein molecules which induce cartilage degradation and bone resorption. In all cases studied, IL-1 mRNA was present in freshly isolated synovial cells from fluid or membrane. Compared to levels of IL-1 mRNA found in optimally activated normal blood mononuclear cells, the levels of IL-1 alpha mRNA were high in seven of the nine patients studied, whereas IL-1 beta mRNA, the dominant form in blood, was relatively lower. TNF alpha and TNF beta mRNA were also detected. Rheumatoid synovial cells, cultured without any stimulus, continued to express high levels of IL-1 alpha mRNA for up to 5 days, compared to the 24 h response of activated blood cells; IL-1 beta mRNA in culture was also prolonged. Cultures of rheumatoid joint cells produced IL-1 bioactivity, with roughly equal amounts of IL-1 alpha and beta, as assessed using neutralizing antibodies. TNF bioactivity was also detected which may be of importance as TNF induces the production of IL-1. The finding of these mediators produced in large amounts in active rheumatoid synovial cells suggests that mutually stimulatory cell interactions, mediated by these molecules, may be important in the chronic inflammation and tissue destruction in rheumatoid arthritis.
Fruit Quantity and Quality Estimation using a Robotic Vision System (2018)

Accurate localisation of crop remains highly challenging in unstructured environments such as farms. Many of the developed systems still rely on the use of hand selected features for crop identification and often neglect the estimation of crop quantity and quality, which is key to assigning labor during farming processes. To alleviate these limitations we present a robotic vision system that can accurately estimate the quantity and quality of sweet pepper (Capsicum annuum L), a key horticultural crop. This system consists of three parts: detection, quality estimation, and tracking. Efficient detection is achieved using the FasterRCNN framework. Quality is then estimated in the same framework by learning a parallel layer which we show experimentally results in superior performance than treating quality as extra classes in the traditional Faster-RCNN framework. Evaluation of these two techniques outlines the improved performance of the parallel layer, where we achieve an F1 score of 77.3 for the parallel technique yet only 72.5 for the best scoring (red) of the multi-class implementation. To track the crop we present a tracking via detection approach, which uses the FasterRCNN with parallel layers, that is also a vision-only solution. This approach is cheap to implement as it only requires a camera and in experiments across 2 days we show that our proposed system can accurately estimate the number of sweet pepper present, within 4.1% of the ground truth.
Influenza virus M2 protein and haemagglutinin conformation changes during intracellular transport. (1995)

The influenza virus M2 protein has an ion channel activity that permits ions to enter the virion during its uncoating and also modulates pH of intracellular compartments. M2 protein is a homotetramer consisting of either a pair of disulfide-linked dimers or a disulfide-linked tetramer. The M2 trans-membrane domain peptide adopts an alfa helical secondary structure. In polarized cells, M2 protein is expressed at the apical cell surface. The amantadine-induced, M2-mediated conversion of influenza A virus haemagglutinin (HA) to the low pH conformation occurs in an acidic trans-Golgi compartment. The M2 protein ion channel activity can affect the conformation of cleaved HA during intracellular transport. The equine influenza virus 1 HA expressed from cDNA does not require coexpression of a functional M2 protein to maintain HA in its native conformation.
Memristor-based circuits for performing basic arithmetic operations (2011)

In almost all of the currently working circuits, especially in analog circuits implementing signal processing applications, basic arithmetic operations such as multiplication, addition, subtraction and division are performed on values which are represented by voltages or currents. However, in this paper, we propose a new and simple method for performing analog arithmetic operations which in this scheme, signals are represented and stored through a memristance of the newly found circuit element, i.e. memristor, instead of voltage or current. Some of these operators such as divider and multiplier are much simpler and faster than their equivalent voltage-based circuits and they require less chip area. In addition, a new circuit is designed for programming the memristance of the memristor with predetermined analog value. Presented simulation results demonstrate the effectiveness and the accuracy of the proposed circuits.
KinectFusion: Real-time dense surface mapping and tracking (2011)

We present a system for accurate real-time mapping of complex and arbitrary indoor scenes in variable lighting conditions, using only a moving low-cost depth camera and commodity graphics hardware. We fuse all of the depth data streamed from a Kinect sensor into a single global implicit surface model of the observed scene in real-time. The current sensor pose is simultaneously obtained by tracking the live depth frame relative to the global model using a coarse-to-fine iterative closest point (ICP) algorithm, which uses all of the observed depth data available. We demonstrate the advantages of tracking against the growing full surface model compared with frame-to-frame tracking, obtaining tracking and mapping results in constant time within room sized scenes with limited drift and high accuracy. We also show both qualitative and quantitative results relating to various aspects of our tracking and mapping system. Modelling of natural scenes, in real-time with only commodity sensor and GPU hardware, promises an exciting step forward in augmented reality (AR), in particular, it allows dense surfaces to be reconstructed in real-time, with a level of detail and robustness beyond any solution yet presented using passive computer vision.
Steric measurement of substituted cyclopentadiene ligands and the synthesis and proton NMR spectral analysis of [(.eta.5-C5H4R)Fe(CO)(L)I] complexes with variable R (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteric measurement of substituted cyclopentadiene ligands and the synthesis and proton NMR spectral analysis of [(.eta.5-C5H4R)Fe(CO)(L)I] complexes with variable RNeil J. Coville, Mohammed S. Loonat, David White, and Laurence CarltonCite this: Organometallics 1992, 11, 3, 1082–1090Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/om00039a013https://doi.org/10.1021/om00039a013research-articleACS PublicationsRequest reuse permissionsArticle Views514Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Analysis of gene expression in osteogenic cultured marrow/hydroxyapatite construct implanted at ectopic sites: A comparison with the osteogenic ability of cancellous bone (1998)

We investigated the in vivo osteogenic ability of cultured marrow cells subcultured in porous hydroxyapatite. This osteogenic ability was compared with that of cancellous bone grafts. Fresh marrow cells were obtained from young adult rat femora and cultured in a standard medium for 10 days, then trypsinized and used to make constructs of porous hydroxyapatite (HA) and cultured marrow cells. An additional 2-week culture (subculture) was performed for the construct in standard medium with and without the addition of dexamethasone (Dex). The 2-week subcultured constructs then were implanted into subcutaneous sites of syngeneic rats. These implants and the rat cancellous bone were harvested and prepared for gene expression analysis of alkaline phosphatase (ALP) and osteocalcin (OC) as well as for histological analysis. ALP and OC mRNAs could be detected in Dex-treated subcultured constructs 1 week after implantation, with an increase at 2 weeks, comparable to the observation in cancellous bone. Histological analysis showed active bone formation even 1 week postimplantation. In contrast, the subcultured constructs without the addition of Dex did not show bone formation, and only small levels of ALP and OC mRNAs were found. These results indicate that the bone tissue formed by grafting the Dex-treated construct of cultured marrow cells and hydroxyapatite possesses a high osteoblastic activity comparable to that of viable cancellous bone. Thus the prefabricated osteogenic subcultured marrow/HA construct may be applicable in bone reconstructive surgery. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 568–573, 1998.
Distributed Subgradient Methods for Multi-Agent Optimization (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We study a distributed computation model for optimizing a sum of convex objective functions corresponding to multiple agents. For solving this (not necessarily smooth) optimization problem, we consider a subgradient method that is distributed among the agents. The method involves every agent minimizing his/her own objective function while exchanging information locally with other agents in the network over a time-varying topology. We provide convergence results and convergence rate estimates for the subgradient method. Our convergence rate results explicitly characterize the tradeoff between a desired accuracy of the generated approximate optimal solutions and the number of iterations needed to achieve the accuracy. </para>
Alpha-Toxin Contributes to Biofilm Formation among Staphylococcus aureus Wound Isolates (2018)

Biofilms complicate treatment of <i>Staphylococcus aureus</i> (SA) wound infections. Previously, we determined alpha-toxin (AT)-promoted SA biofilm formation on mucosal tissue. Therefore, we evaluated SA wound isolates for AT production and biofilm formation on epithelium and assessed the role of AT in biofilm formation. Thirty-eight wound isolates were molecularly typed by pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (ST), and <i>spa</i> typing. We measured biofilm formation of these SA isolates in vitro and ex vivo and quantified ex vivo AT production. We also investigated the effect of an anti-AT monoclonal antibody (MEDI4893*) on ex vivo biofilm formation by methicillin-resistant SA (USA 300 LAC) and tested whether purified AT rescued the biofilm defect of <i>hla</i> mutant SA strains. The predominant PFGE/ST combinations were USA100/ST5 (50%) and USA300/ST8 (33%) for methicillin-resistant SA (MRSA, <i>n</i> = 18), and USA200/ST30 (20%) for methicillin-susceptible SA (MSSA, <i>n</i> = 20). Ex vivo AT production correlated significantly with ex vivo SA wound isolate biofilm formation. Anti-alpha-toxin monoclonal antibody (MEDI4893*) prevented ex vivo biofilm formation by MRSA USA300 strain LAC. Wild-type AT rescued the ex vivo biofilm defect of non-AT producing SA strains. These findings provide evidence that AT plays a role in SA biofilm formation on epithelial surfaces and suggest that neutralization of AT may be useful in preventing and treating SA infections.