gebhart/patrepeval huggingface dataset:
<scp>Longevity Bonds: Financial Engineering, Valuation, and Hedging</scp> (2006)

Abstract This article examines the main characteristics of longevity bonds (LBs) and shows that they can take a large variety of forms which can vary enormously in their sensitivities to longevity shocks. We examine different ways of financially engineering LBs and consider problems arising from the dearth of ultra‐long government bonds and the choice of the reference population index. The article also looks at valuation issues in an incomplete markets context and finishes with an examination of how LBs can be used as a risk management tool for hedging longevity risks.
The splenic autoimmune response to ADAMTS13 in thrombotic thrombocytopenic purpura contains recurrent antigen-binding CDR3 motifs (2014)

Acquired thrombotic thrombocytopenic purpura (TTP) is the consequence of a severe ADAMTS13 deficiency resulting from autoantibodies inhibiting ADAMTS13 or accelerating its clearance. Despite the success of plasma exchange the risk of relapse is high. From 2 patients (A and B), splenectomized for recurrent episodes of acquired TTP, the splenic B-cell response against ADAMTS13 was characterized through generation of human monoclonal anti-ADAMTS13 autoantibodies (mAbs) by cloning an immunoglobulin G (IgG)4κ- and IgG4λ-Fab library using phage display technology and by Epstein-Barr virus transformation of switched memory B cells (CD19+/CD27+/IgG+). Sequence analysis of the anti-ADAMTS13 IgGs of both patients revealed that the VH gene use was limited in our patients to VH1-3 (55%), VH1-69 (17%), VH3-30 (7%), and VH4-28 (21%) and contained 8 unique and thus far not reported heavy-chain complementarity determining region 3 motifs, of which 4 were shared by the 2 patients. The discovery of several highly similar anti-ADAMTS13 autoantibodies in 2 unrelated TTP patients suggests that the autoimmune response is antigen driven, because the probability that such similar immunoglobulin rearrangements happen by chance is very low (< 10(-9)).
iCanDraw (2010)

When asked to draw, many people are hesitant because they consider themselves unable to draw well. This paper describes the first system for a computer to provide direction and feedback for assisting a user to draw a human face as accurately as possible from an image. Face recognition is first used to model the features of a human face in an image, which the user wishes to replicate. Novel sketch recognition algorithms were developed to use the information provided by the face recognition to evaluate the hand-drawn face. Two design iterations and user studies led to nine design principles for providing such instruction, presenting reference media, giving corrective feedback, and receiving actions from the user. The result is a proof-of-concept application that can guide a person through step-by-step instruction and generated feedback toward producing his/her own sketch of a human face in a reference image.
Rootkit Detection Experiment within a Virtual Environment (2010)

In the context of virtual environments, the security problems are highly important. The paper presents some results of experiments we have carried out within the real virtual machine environment through modeling aiming to identify dependencies between the virus, called Rootkits, detection time and the virtual machine memory size. Rootkits exploit kernel vulnerabilities and gain privileges (popularity) within any system, virtual or not. The basic result of the paper is as follows: 1) the Rootkits detection methodology for the virtual environment when the memory size of a virtual machine is changing; 2) dependences between the virtual machine memory size and Rootkit detection time.
Optical Waveguides (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptical WaveguidesIlan Chabay1Cite this: Anal. Chem. 1982, 54, 9, 1071A–1080APublication Date (Print):August 1, 1982Publication History Published online7 June 2012Published inissue 1 August 1982https://pubs.acs.org/doi/10.1021/ac00246a780https://doi.org/10.1021/ac00246a780research-articleACS PublicationsRequest reuse permissionsArticle Views56Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fabrication and Characteristics of Schottky Gated Poly(3-alkylthiophene) Field Effect Transistors (1991)

Fabrication and characterization of Schottky gated poly(3-alkylthiophene) field effect transistors have been reported. The transistors have been realized using free-standing poly(3-alkylthiophene) films with Schottky gated electrode configuration with low drive voltages. From the FET characteristics, the carrier mobility is evaluated to be 3×10 -3 cm 2 /V·s.
Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes (2014)

The endocannabinoid system (ECS) regulates multiple physiological processes, including cutaneous cell growth and differentiation. Here, we explored the effects of the major nonpsychotropic phytocannabinoid of Cannabis sativa, (-)-cannabidiol (CBD), on human sebaceous gland function and determined that CBD behaves as a highly effective sebostatic agent. Administration of CBD to cultured human sebocytes and human skin organ culture inhibited the lipogenic actions of various compounds, including arachidonic acid and a combination of linoleic acid and testosterone, and suppressed sebocyte proliferation via the activation of transient receptor potential vanilloid-4 (TRPV4) ion channels. Activation of TRPV4 interfered with the prolipogenic ERK1/2 MAPK pathway and resulted in the downregulation of nuclear receptor interacting protein-1 (NRIP1), which influences glucose and lipid metabolism, thereby inhibiting sebocyte lipogenesis. CBD also exerted complex antiinflammatory actions that were coupled to A2a adenosine receptor-dependent upregulation of tribbles homolog 3 (TRIB3) and inhibition of the NF-κB signaling. Collectively, our findings suggest that, due to the combined lipostatic, antiproliferative, and antiinflammatory effects, CBD has potential as a promising therapeutic agent for the treatment of acne vulgaris.
Automatic unsupervised parameter selection for character segmentation (2010)

A major difficulty for designing a document image segmentation methodology is the proper value selection for all involved parameters. This is usually done after experimentations or after involving a training supervised phase which is a tedious process since the corresponding segmentation ground truth has to be created. In this paper, we propose a novel automatic unsupervised parameter selection methodology that can be applied to the character segmentation problem. It is based on clustering of the entities obtained as a result of the segmentation for different values of the parameters involved in the segmentation method. The clustering is performed using features extracted from the segmented entities based on zones and from the area that is formed from the projections of the upper/lower and left/right profiles. Optimization of an appropriate intra-class distance measure yields the optimal parameter vector. The method is evaluated on two segmentation algorithms, namely a recently proposed character segmentation technique based on skeleton segmentation paths, as well as the well known RLSA technique. The proposed parameter selection method is capable of finding the segmentation parameters that correspond to the optimal or near optimal segmentation result, as this is determined by counting the number of matches between the entities detected by the segmentation algorithm and the entities in the ground truth.
A Rubber-Like Protein in Insect Cuticle (1960)

ABSTRACT The cuticle of arthropods is complex and varies enormously in structure, properties and composition even within the same species (cf. Richards, 1951). However, the mechanical behaviour is dominated by materials in the solid state of matter so that the mature cuticles hitherto described in the literature may be classed as solid cuticle. It was therefore surprising to find that certain patches of the exoskeleton in many insects exhibit long-range reversible elasticity of the rubber-like type. This paper describes three examples of rubber-like cuticle from locusts (Orthoptera) and dragonflies (Odonata). Similar structures have been found in all winged insects hitherto examined (Weis-Fogh, unpublished). Essentially the present survey is a qualitative analysis of the material basis for the rubber-like properties of three selected samples, based upon simple tests and techniques. The main conclusion is that the characteristic elasticity is caused by a peculiar protein, called resilin, which differs from other structural proteins also in respect of amino-acid composition (Bailey &amp; Weis-Fogh, 1961). Resilin is insoluble in all solvents which do not break peptide bonds and since it is located as an integral part of the highly organized cuticle it is necessary to analyse the three samples in detail as to structure and many other properties. Only in this way is it permissible to conclude that the elasticity depends on only one type of substance and to characterize it in general terms.
ECG-gated pinhole SPECT in mice with millimeter spatial resolution (2000)

The authors have developed a single photon emission computed tomography (SPECT) technique for high resolution radiotracer imaging of mice where the object is rotated instead of the scintillation camera. The system uses a 21 cm focal length pinhole collimator with a 0.5 mm diameter aperture, resulting in magnification ranging from 7 to 10 and acquisition times from 60 to 90 minutes. This method employs a plastic mouse-holding tube designed to address specific problems associated with pinhole SPECT, including low count rates and correction for shift of the center of rotation. Images of a novel "mouse heart" phantom demonstrated good image quality, uniformity, and spatial resolution. A /sup 99m/Tc-sestamibi scan of a normal mouse, electrocardiogram-gated at over 400 beats per minute, allowed assessment of regional myocardial perfusion and evaluation of ventricular wall motion. An ungated perfusion scan produced images with millimeter spatial resolution and quality comparable to human images, allowing the visualization of the left and right ventricular myocardium.
LIPIDS OF <i>ACANTHAMOEBA CASTELLANII </i> (1969)

The lipids of Acanthamoeba castellanii (Neff) consist of 52% neutral lipids and 48% polar lipids. Triglycerides account for 75% and free sterols for 17% of the neutral lipids. The major phospholipids are phosphatidylcholine (45%), phosphatidylethanolamine (33%), phosphatidylserine (10%), a phosphoinositide (6%), and diphosphatidylglycerol (4%). The phosphoinositide is unique in that it contains fatty acids, aldehyde, inositol, and phosphate in the ratio of 1.4:0.5:1.1, but it contains no glycerol. Sphingomyelin, cerebrosides, psychosine, and glycoglycerides were not detected, but small amounts of unidentified long chain bases and sugars are present. The rates of uptake of palmitate-1-(14)C and of its incorporation into glycerides and phospholipids were not affected by the phagocytosis of polystyrene latex beads. Although phagocytosis usually decreased the uptake by amebas of phosphate-(32)P, serine-U-(14)C, and inositol-2-(3)H, their subsequent incroporation into phospholipids was not demonstrably stimulated or inhibited by phagocytosis. Phagocytosis did seem to increase the incorporation into ameba phospholipids of phosphatidylcholine-1 ,2-(14)C but not that of phosphatidylethanolamine-1 ,2-(14)C. These experiments, in which the incorporation of radioactive precursors into total cell lipids was measured, do not, of course, eliminate the possibility that localized effects may occur.
Microwave synthesis of Au–Rh core–shell nanoparticles and implications of the shell thickness in hydrogenation catalysis (2013)

A microwave-assisted heating method allows for the convenient and reproducible synthesis of defined Au-Rh core-shell metallic nanoparticles with tuneable shell thicknesses. Nanoparticles with shells as thin as two Rh monolayers can be prepared, which are effective in vapour-phase hydrogenation catalysis at room temperature without the need for pre-treatment. Particles with Rh shells consisting of two or four Rh overlayers show similar catalytic properties and are both significantly more highly active than pure Rh nanoparticles, per mol of Rh employed.
The use of emphasis to automatically summarize a spoken discourse (1992)

The authors describe a method for exploiting prosodic information in natural, conventional speed for the purpose of automatically creating an audio summary. The method is based on identifying emphasized speech and then using proximity measures on the emphasized regions to select summarizing excerpts. Emphasized speech is recognized using a hidden Markov model using only non-spectral, periodic information. Syllable-based models were created and the models trained on spontaneous speech in which words had been labeled by a panel of listeners for degree of emphasis. Emphatic speech from one speaker was automatically detected and summarizing excerpts were identified, with no noticeable difference when compared to excerpts selected by individual subjects. The extensibility of the emphasis detector to other speakers was tested on a small sample of telephone speech by ten other speakers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Current-perpendicular-to-plane-magnetoresistance properties of Ru and Co/Ru interfaces (2002)

Recent interest in Ru and Co/Ru multilayers stimulated us to measure their properties in the current-perpendicular-to-plane (CPP) geometry at 4.2 K. For sputtered samples, we present results for the resistivity of Ru, the interface specific resistances of Cu/Ru and Co/Ru, the spin-memory-loss length lsfRu in Ru, the spin-memory-loss probability at Cu/Ru interfaces, and the spin-scattering anisotropy parameter γ at Co/Ru interfaces.
Multigrid and Gauss-Seidel smoothers revisited (2006)

Efficient solution of partial differential equations require a match between the algorithm and the target architecture. Many recent chip multiprocessors, CMPs (a.k.a. multi-core), feature low intra-thread communication costs and smaller per-thread caches compared to previous shared memory multi-processor systems. From an algorithmic point of view this means that data locality issues become more important than communication overheads. A fact that may require a re-evaluation of many existing algorithms.We have investigated parallel implementations of multi-grid methods using a parallel temporally blocked, naturally ordered smoother. Compared to the standard multigrid solution based on a red-black ordering, we improve the data locality often as much as ten times, while our use of a fine-grained locking scheme keeps the parallel efficiency high.Our algorithm was initially inspired by CMPs and it was surprising to see that our OpenMP multigrid implementation ran up to 40 percent faster than the standard red-black algorithm on a contemporary 8-way SMP system. Thanks to the temporal blocking introduced, our smoother implementation often allowed us to apply the smoother two times at the same cost as a single application of a red-black smoother. By executing our smoother on a 32-thread UltraSPARC T1 (Niagara) SMT/CMP and a simulated 32-way CMP we demonstrate that such architectures can tolerate the increased communication costs implied by the tradeoffs made in our implementation.
Immunologic phenotype of cultured endothelial cells: quantitative analysis of cell surface molecules (1997)

Endothelial cells express a wide spectrum of surface molecules involved in multiple vascular functions. We quantitatively determined an extensive immunologic phenotype of endothelial cells through a large panel of antibodies directed against i) well-known endothelial molecules CD31, CD34, CD49b, e, f, CD51, CD54, CD55, CD62E and P, CD105, CD106, HLA class I and HLA class II; ii) molecules defined by monoclonal antibodies newly clustered during the 6th workshop of Human Leukocyte Differentiation Antigen (HLDA) CD109, CD140b, CD141, CD142, CD143, CD144, CDw145, CD146 and CD147; iii) molecules defined by unclustered monoclonal antibodies. The expression of these molecules was quantified on human umbilical vein endothelial cells (HUVEC) cultured in resting conditions and after stimulation with IL-1beta (10 U/ml), TNF-alpha (10 ng/ml) and phorbol myristate acetate (60 ng/ml). Some molecules were constitutively expressed, and others were negative, which served to determine the basal phenotype. After cell stimulation, the molecules showed weak or strong expression modulation, leading to the definition of an activated phenotype. Changes in the kinetics and the amplitude of expression served to characterize poorly defined molecules and may be useful to determine their physiologic role. Also, we compared the phenotypes of endothelial cell lines EA.hy 926 and ECV 304 to that of HUVEC to assess their reliability as an endothelial cell model. Each cell line displayed a specific repertoire of molecules expressed at different levels, which could have significant implications for cell line behavior as endothelial cells.
Specific Knockdown of Oct4 and β2‐microglobulin Expression by RNA Interference in Human Embryonic Stem Cells and Embryonic Carcinoma Cells (2004)

We have used RNA interference (RNAi) to downregulate beta2-microglobulin and Oct4 in human embryonal carcinoma (hEC) cells and embryonic stem (hES) cells, demonstrating that RNAi is an effective tool for regulating specific gene activity in these human stem cells. The knockdown of Oct4 but not beta2-microglobulin expression in both EC and ES cells resulted in their differentiation, as indicated by a marked change in morphology, growth rate, and surface antigen phenotype, with respect to SSEA1, SSEA3, and TRA-1-60 expression. Expression of hCG and Gcm1 was also induced following knockdown of Oct4 expression, in both 2102Ep hEC cells and in H7 and H14 hES cells, consistent with the conclusion that, as in the mouse, Oct4 is required to maintain the undifferentiated stem cell state, and that differentiation to trophectoderm occurs in its absence. NTERA2 hEC cells also differentiated, but not to trophectoderm, suggesting their equivalence to a later stage of embryogenesis than other hEC and hES cells.
Syntheses in the isoquinoline series. Synthesis of 2,3-dihydro-4(1H)-isoquinolones (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses in the isoquinoline series. Synthesis of 2,3-dihydro-4(1H)-isoquinolonesGuenter Grethe, Hsi Lin Lee, Milan Uskokovic, and Arnold BrossiCite this: J. Org. Chem. 1968, 33, 2, 491–494Publication Date (Print):February 1, 1968Publication History Published online1 May 2002Published inissue 1 February 1968https://pubs.acs.org/doi/10.1021/jo01266a003https://doi.org/10.1021/jo01266a003research-articleACS PublicationsRequest reuse permissionsArticle Views382Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Detection of conflicting functional requirements in a use case-driven approach (2002)

In object-oriented software development, requirements of different stakeholders are often manifested in use case models which complement the static domain model by dynamic and functional requirements. In the course of development, these requirements are analyzed and integrated to produce a consistent overall requirements specification. Iterations of the model may be triggered by conflicts between requirements of different parties.However, due to the diversity, incompleteness, and informal nature, in particular of functional and dynamic requirements, such conflicts are difficult to find. Formal approaches to requirements engineering, often based on logic, attack these problems, but require highly specialized experts to write and reason about such specifications.In this paper, we propose a formal interpretation of use case models consisting of UML use case, activity, and collaboration diagrams. The formalization, which is based on concepts from the theory of graph transformation, allows to make precise the notions of conflict and dependency between functional requirements expressed by different use cases. Then, use case models can be statically analyzed, and conflicts or dependencies detected by the analysis can be communicated to the modeler by annotating the model.An implementation of the static analysis within a graph transformation tool is presented.
Normally-Off GaN n-MOSFET with Schottky-Barrier Source and Drain on a p-GaN on Silicon Substrate. (2006)

We fabricated a schottky barrier metal oxide semiconductor field effect transistor (SB-MOSFET) for the first time on a p-GaN with silicon auto doping into the nitrogen site, grown on silicon substrate. The source/drain and gate metals were formed by aluminum and gold, respectively. PECVD SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> was used as a gate dielectric. The fabricated devices exhibited threshold voltage of 1.65 V, and maximum transconductance of 1.6 mS/mm at V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DS</inf> =5 V. The normalized on-current was 3 mA/mm and the off-current was as low as 3x10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-9</sup> A/mm.