gebhart/patrepeval huggingface dataset:
Melatonin reduces disseminate neuronal death after mild focal ischemia in mice via inhibition of caspase‐3 and is suitable as an add‐on treatment to <i>tissue</i>‐plasminogen activator (2004)

The effects of i.p. melatonin (4 + 4 mg/kg, after induction of ischemia and at reperfusion onset) administered either alone or in combination with the thrombolytic tissue-plasminogen activator (t-PA, 10 mg/kg), on cerebral laser Doppler flow (LDF) and ischemic injury were studied after 30 min of middle cerebral artery (MCA) thread occlusion in male C57BL/6 mice. Thread occlusions resulted in reproducible focal ischemias, followed by hyperperfusion reactions immediately after thread withdrawal, as revealed by LDF measurements. Compared with animals receiving normal saline (peak LDF after reperfusion: 172.0 +/- 24.2%), postischemic LDF was significantly attenuated in animals treated with melatonin (105.1 +/- 6.7%, P < 0.05). Delivery of t-PA (132.8 +/- 22.3%) or t-PA plus melatonin (164.7 +/- 36.7%), on the contrary, did not influence postischemic LDF recordings. Twenty-four hours after reperfusion, melatonin treated mice had significantly increased neuronal survival and decreased disseminate cell injury in the ischemia-vulnerable striatum, as investigated by cresyl violet and terminal transferase biotinylated-dUTP nick end labeling stainings. The protective effects were associated with inhibition of caspase-3 activity. Melatonin administration also increased neuronal survival after 30 min MCA occlusion in animals treated with t-PA, although t-PA itself already decreased the degree of injury in a significant manner. Our data demonstrate that melatonin reduces disseminated neuronal injury in the striatum after mild focal ischemia. Brain protection is independent of hemodynamic changes and involves inhibition of caspase-3.
Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma (2016)

Palbociclib shows encouraging results in preclinical models of HCC and represents a novel therapeutic strategy for HCC treatment, alone or particularly in combination with sorafenib. Palbociclib could potentially benefit patients with RB1-proficient tumours, which account for 70% of all patients with HCC.
A One-Dimensional Focusing Critical Angle Refractometer for Mass Transfer Studies (1972)

A focusing critical angle refractometer has been constructed to measure the one-dimensional refractive index profile immediately adjacent to the glass wall of a liquid container. The instrument displays a graphic image of the entire refractive index profile. It is capable of resolving concentration differences of 10−4 M (10−5 refractive index units) and distances of 0.02 mm.
Mitochondrial DNA common deletion is not associated with thyroid, breast and colorectal tumors in Turkish patients (2009)

Recently, efforts have been focused on mitochondrial DNA changes and their relation to human cancers. Among them, a 4977 bp deletion of mitochondrial DNA, named "common deletion", has been investigated in several types of tumors, with inconsistent results. In this study, we investigated the presence of the common deletion in tissues from 25 breast, 25 colorectal and 50 thyroid tumors and in the adjacent healthy tissues from Turkish patients. Samples from healthy volunteers were also evaluated for comparison. Two PCR-based methods were used for the detection of the common deletion. First, two pairs of primers were used to amplify wild-type and deleted mtDNA. Then, a highly sensitive nested-PCR was performed, to determine low amounts of deleted genomes. By the first method, wild-type mtDNAs were observed in all samples, but a deletion was observed in only six thyroid samples, by using the nested-PCR method. In conclusion, the mitochondrial common deletion was very rare in our study group and did not appear to be not related with cancer.
Non–Small-Cell Lung Cancer and Ba/F3 Transformed Cells Harboring the ERBB2 G776insV_G/C Mutation Are Sensitive to the Dual-Specific Epidermal Growth Factor Receptor and ERBB2 Inhibitor HKI-272 (2006)

Mutation-specific cancer therapy has shown promising clinical efficacy. In non-small-cell lung cancer (NSCLC), the presence of mutations in the epidermal growth factor receptor (EGFR) tyrosine kinase correlates with clinical response to small-molecule tyrosine kinase inhibitors. Here, we show that cells harboring the G776insV_G/C mutation in the related ERBB2 tyrosine kinase (also known as HER2 or Neu), present in a small percentage of NSCLCs, are sensitive to HKI-272, an irreversible dual-specific kinase inhibitor targeting both EGFR and ERBB2. In the ERBB2-mutant NCI-H1781 cell line, HKI-272 treatment inhibited proliferation by induction of G(1) arrest and apoptotic cell death. Furthermore, HKI-272 abrogated autophosphorylation of both ERBB2 and EGFR. Finally, Ba/F3 murine pro-B cells, engineered to express mutant ERBB2, became independent of interleukin-3 and sensitive to HKI-272. Thus, the subset of NSCLC patients with tumors carrying the ERBB2 G776insV_G/C mutation may benefit from treatment with HKI-272.
Interactions Between Monoamines, Glutamate, and GABA in Schizophrenia: New Evidence (2001)

In spite of its proven heuristic value, the dopamine hypothesis of schizophrenia is now yielding to a multifactorial view, in which the other monoamines as well as glutamate and GABA are included, with a focus on neurotransmitter interactions in complex neurocircuits. The primary lesion(s) in schizophrenia does not necessarily involve any of these neurotransmitters directly but could deal with a more general defect, such as a faulty connectivity of developmental origin. Nevertheless, a precise identification of neurotransmitter aberrations in schizophrenia will probably provide clues for a better understanding of the disease and for the development of new treatment and prevention strategies.
The Data Webhouse Toolkit: Building the Web‐enabled Data Warehouse (2000)

BRINGING THE WEB TO THE WAREHOUSE. Why Bring the Web to the Warehouse? Tracking Website User Actions. Using the Clickstream to Make Decisions. Understanding the Clickstream as a Data Source. Designing the Website to Support Warehousing. Building Clickstream Data Marts. Assembling Clickstream Value Chains. Implementing the Clickstream Post-Processor. BRINGING THE WAREHOUSE TO THE WEB. Why Bring the Warehouse to the Web? Designing the User Experience. Driving Data Mining from the Webhouse. Creating an International Data Webhouse. Data Webhouse Security. Scaling the Webhouse. Managing the Webhouse Project. The Future of Webhousing. Glossary of Abbreviations and Terms. Bibliography. Index.
Associative Computing: A Programming Paradigm for Massively Parallel Computers (1992)

Integrating associative processing concepts with massively parallel SIMD technology, this volume explores a model for accessing data by content rather than abstract address mapping.
Phosphonate Analogues of Cytosine Arabinoside Monophosphate (2002)

Phosphonate derivatives of cytidine and cytosine arabinoside have been prepared from the corresponding nucleoside aldehydes and tested for their ability to serve as substrates for nucleotide monophosphate kinase and for their toxicity to K562 leukemia cells.
Divergent Enantioselective Synthesis of (−)-Galanthamine and (−)-Morphine (2005)

An efficient divergent synthetic strategy for the synthesis of the opiate and amaryllidaceae alkaloids emerges by employing a Pd-catalyzed asymmetric allylic alkylation (AAA) to set the stereochemistry. Three generations of syntheses of galanthamine are discussed in detail with particular focus on the scope of the palladium-catalyzed AAA reactions and intramolecular Heck reactions. The pivotal tricyclic intermediate is available in six steps from 2-bromovanillin and the monoester of methyl 6-hydroxycyclohexene-1-carboxylate. This intermediate requires only two steps to convert to (-)-galanthamine. Using a Heck vinylation, we found that the fourth ring of codeine/morphine could be formed. The final ring formation involves a novel visible light-promoted hydroamination. Thus, six steps are required to convert the pivotal tricyclic intermediate into codeine, which has been demethylated in high yield to morphine.
Inducible Control of Virulence Gene Expression in <i>Listeria monocytogenes</i> : Temporal Requirement of Listeriolysin O during Intracellular Infection (2002)

We have constructed a lac repressor/operator-based system to tightly regulate expression of bacterial genes during intracellular infection by Listeria monocytogenes. An L. monocytogenes strain was constructed in which expression of listeriolysin O was placed under the inducible control of an isopropyl-beta-D-thiogalactopyranoside (IPTG)-dependent promoter. Listeriolysin O (LLO) is a pore-forming cytolysin that mediates lysis of L. monocytogenes-containing phagosomes. Using hemolytic-activity assays and Western blot analysis, we demonstrated dose-dependent IPTG induction of LLO during growth in broth culture. Moreover, intracellular growth of the inducible-LLO (iLLO) strain in the macrophage-like cell line J774 was strictly dependent upon IPTG. We have further shown that iLLO bacteria trapped within primary phagocytic vacuoles can be induced to escape into the cytosol following addition of IPTG to the cell culture medium, thus yielding the ability to control bacterial escape from the phagosome and the initiation of intracellular growth. Using the iLLO strain in plaque-forming assays, we demonstrated an additional requirement for LLO in facilitating cell-to-cell spread in L2 fibroblasts, a nonprofessional phagocytic cell line. Furthermore, the efficiency of cell-to-cell spread of iLLO bacteria in L2 cells was IPTG dose dependent. The potential use of this system for determining the temporal requirements of additional virulence determinants of intracellular pathogenesis is discussed.
Saccular Aneurysm Induction by Elastase Digestion of the Arterial Wall: A New Animal Model (1998)

Arterial saccular aneurysms were induced in rabbits by topical application of elastase with an easy and efficient method. These aneurysms are histologically similar to natural aneurysms, and their arterial nature renders them more authentic than those of surgical models. This aneurysm model may serve as a foundation for further aneurysm research.
Oriented Perforations - A Rock Mechanics View (1994)

Abstract Hydraulic fracture initiation dictates the communication path between the wellbore and fracture plane. Nonplanar fracture geometries such as multiple, T-Shaped, and reoriented fractures are not advantageous and they adversely affect the potential to achieve a desired stimulation treatment. Oriented perforation can be the solution to initiate a single wide fracture in vertical and deviated wells. Also oriented perforations may be used to create stable tunnels in poorly consolidated formations thus avoiding sand failure and consequently preventing sand production. This paper presents laboratory experimental results related to oriented perforations for hydraulic fracturing. It also discusses the use of oriented perforation for sand control. Experiments were designed to investigate the effect of perforation orientation in vertical and horizontal wells on hydraulic fracturing treatment.
A low&#8211;power truly&#8211;modular 1.8GHz programmable divider in standard CMOS technology (1999)

We present a modular and scalable divider architecture that is especially suited for low power applications. The implementation of the divider cells in SCL is described, and a new design method for power dissipation optimization, based on an AC simulation technique, is introduced. An 18bit implementation of the architecture in a conservative 0.35µm bulk CMOS technology is described, which achieved state-of-the-art power efficiency and input sensitivity for CMOS silicon technologies.
History-Adjusted Marginal Structural Analysis of the Association between Hemoglobin Variability and Mortality among Chronic Hemodialysis Patients (2008)

Marginal structural analysis demonstrates that hemoglobin variability is associated with increased mortality among chronic hemodialysis patients, and that this effect is more pronounced than appreciated using standard statistical techniques that do not take time-dependent confounding into account.
Remotely manned systems: Exploration and operation in space; Proceedings of the First National Conference, California Institute of Technology, Pasadena, Calif., September 13-15, 1972. (1973)

Free-flying teleoperator systems are discussed, giving attention to earth-orbit mission considerations and Space Tug requirements, free-flying teleoperator requirements and conceptual design, system requirements for a free-flying teleoperator to despin, and the experimental evaluation of remote manipulator systems. Shuttle-Attached Manipulator Systems are considered, together with remote surface vehicle systems, manipulator systems technology, remote sensor and display technology, the man-machine interface, and control and machine intelligence. Nonspace applications are also explored, taking into account implications of nonspace applications, naval applications of remote manipulators, and hand tools and mechanical accessories for a deep submersible. Individual items are announced in this issue.
Metallacarboranes as labile anions for ionic zirconocene olefin polymerization catalysts (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetallacarboranes as labile anions for ionic zirconocene olefin polymerization catalystsGregory G. Hlatky, Richard R. Eckman, and Howard W. TurnerCite this: Organometallics 1992, 11, 3, 1413–1416Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/om00039a058https://doi.org/10.1021/om00039a058research-articleACS PublicationsRequest reuse permissionsArticle Views199Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Confidence (2001)

Journal Article Confidence Get access Jo Williams Jo Williams Search for other works by this author on: Oxford Academic Google Scholar The British Journal of Social Work, Volume 31, Issue 4, 1 August 2001, Pages 631–632, https://doi.org/10.1093/bjsw/31.4.631 Published: 01 August 2001
A Method for the Removal of Endotoxin from Purified Colony-Stimulating Factor (1980)

Limulus lysate assays showed that several samples of purified L-cell CSF were markedly contaminated with endotoxin. Several pools of material contained 1 to 10 μg/ml of this bacterial lipopoly-saccharide. Ultracentrifugation in sucrose density gradients led to a 95% separation of CSF and endotoxin activities. In four studies, endotoxin content of the CSF preparations was reduced to levels varying from 0.05 to 0.0001 μg/ml.
Reducing Fatigue in Wind-Excited Traffic Signal Support Structures using Smart Damping Technologies (2011)

This Innovations Deserving Exploratory Analysis (IDEA) project developed and tested an innovative signal head vibration absorber (SHVA) that provides energy absorption for lightly damped signal support structures to reduce vibration and fatigue in these structures from excessive wind-induced vibration. The SHVA is a modified vehicle signal head that incorporates a reliable and robust spring and damper inside of the signal housing to allow for the signal head to move vertically relative to the mast arm. As the mass of the signal head moves up and down relative to the mast-arm, energy is dissipated and vibration is greatly reduced.
Visualizing the execution of High Performance Fortran (HPF) programs (2002)

Although the data placement programming model frees programmers from writing low level communication code, it also makes it harder for them to anticipate the performance of the code they write. In particular, the communication that is required by a given data distribution, and its impact on performance, may not be obvious from the program source. Many existing performance visualization systems could be used in attempts to investigate the performance of data placement programs; however, no published system would provide views that relate communication activity to the abstraction that is the primary focus of data placement programming: data distribution. The paper introduces new high level views of HPF program behavior that show communication activity in the context of the array distribution from which the compiler derived the communication. With these views, programmers can see not only when and where communication takes place, but also what subarrays are moving between which processors by virtue of the communication. These views provide programmers with feedback in terms of the programming model-the programmers' frame of reference. The programming model as the level programmers most readily comprehend, and it is the level at which they must improve program performance by altering data distribution. Thus, these views provide a basis for effective tuning of data placement programs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments. (1995)

In human B cells, class II molecules of the major histocompatibility complex (MHC-II) accumulate in an endosomal/lysosomal compartment, the MIIC, in which they may encounter and bind peptides. An additional molecule required for MHC-II peptide binding, HLA-DM (DM), has also been localized to the MIIC. Neither the relationship of the MIIC to the endosomal system nor the mechanisms by which DM localizes to the MIIC are understood. To address these issues, DM localization was analyzed in cells that do or do not express MHC-II. DM alpha beta heterodimers were localized in transfected MHC-II-negative HeLa and NRK cells, in the absence of the MHC-II-associated invariant chain, to a prelysosomal/lysosomal compartment by immunofluorescence microscopy. To identify a potential targeting determinant, we analyzed the localization of a chimeric protein, T-T-Mb, in which the cytoplasmic tail of murine DM beta (Mb) was appended to the lumenal and transmembrane domains of a cell surface protein, Tac. Like intact DM, T-T-Mb was localized to a lysosomal compartment in HeLa and NRK cells, as judged by immunofluorescence and immunoelectron microscopy. T-T-Mb was rapidly degraded in this compartment by a process that was blocked by inhibitors of lysosomal proteolysis. The DM beta cytoplasmic tail also mediated internalization of anti-Tac antibody from the cell surface and delivery to lysosomes. Deletion from the DM beta cytoplasmic tail of the tyrosine-based motif, YTPL, resulted in cell surface expression of T-T-Mb and a loss of both degradation and internalization; alanine scanning mutagenesis showed that the Y and L residues were critical for these functions. Similarly, mutation of the same Y residue within full-length DM beta resulted in cell surface expression of DM alpha beta heterodimers. Lastly, T-T-Mb was localized by immunoelectron microscopy to the MIIC in a human B lymphoblastoid cell line. Our results suggest that a motif, YTPL, in the cytoplasmic tail of the beta chain of DM is sufficient for targeting either to lysosomes or to the MIIC.
Excision of Deoxyribose Phosphate Residues by DNA Polymerase β During DNA Repair (1995)

Eukaryotic DNA polymerase beta (pol beta) can catalyze DNA synthesis during base excision DNA repair. It is shown here that pol beta also catalyzes release of 5'-terminal deoxyribose phosphate (dRP) residues from incised apurinic-apyrimidinic sites, which are common intermediate products in base excision repair. The catalytic domain for this activity resides within an amino-terminal 8-kilodalton fragment of pol beta, which comprises a distinct structural domain of the enzyme. Magnesium is required for the release of dRP from double-stranded DNA but not from a single-stranded oligonucleotide. Analysis of the released products indicates that the excision reaction occurs by beta-elimination rather than hydrolysis.
Toward robust skin identification in video images (2002)

There are many applications where it is desirable to segment a video image into regions defined by color. Among these are the recognition of gesture from the image (as opposed to instrumented gloves), facial expression and orientation, and video teleconferencing. In these examples, the important elements of the images are human hands and face, which share common skin coloration of the subject. This paper describes an approach to the identification of skin-colored regions of the image that is robust in terms of variations in skin pigmentation in a single subject, differences in skin pigmentation across a population of potential users, and subject clothing and image background. The paper also discusses the potential for being robust over a wide range of illuminating conditions.
Computational holographic bandwidth compression (1996)

A novel technique to compute holographic fringe patterns for real-time display is described. Hogel-vector holographic bandwidth compression, a diffraction-specific approach, treats a fringe as discretized in space and spatial frequency. By undersampling fringe spectra, hogel-vector encoding achieves a compression ratio of 16:1 with an acceptably small loss in image resolution. Hogel-vector bandwidth compression achieves interactive rates of holographic computation for real-time three-dimensional electro-holographic (holovideo) displays. Total computation time for typical three-dimensional images is reduced by a factor of over 70 to 4.0 seconds per 36-MB holographic fringe and under 1.0 seconds for a 6-MB full-color image. Analysis focuses on the trade-offs among compression ratio, image fidelity, and image depth. Hogel-vector bandwidth compression matches information content to the human visual system, achieving "visual-bandwidth holography." Holovideo may now be applied to visualization, entertainment , and information.