gebhart/patrepeval huggingface dataset:
Immunologic diseases of the skin (1991)

The immune system - an overview, Hong the skin as an immunologic organ, Bergstresser cellular immune mechanisms of skin disease, Norris and Weston humoral mechanisms of skin disease, Geoghegan inflammatory mediators, Goldyne et al the mast cell, Tharp the eosinophil, Leiferman mechanisms of immune-mediated injury in the skin, Sell the HLA system and cutaneous disease, Arnett and Hall tumor immunology, Healt and Jegasothy photo-immunology, Granstein and Parrish the primary immunodeficiency syndromes, Herbert and Paller cutaneous manifestations of complement deficiencies, Warner and Jordan cutaneous manifestations of phagocytic disorders, Dahl mucocutaneous candidiasis and candida infections, Ray sarcoidosis, Hanno and Callen epidemic of human immune deficiency syndrome and acquired deficiency syndrome, Safai and Gross atopic dermatitis, Sampson and Hanifin urticaria/angiodema and mastocytosis, Soter allergic contact dermatitis, Tron and Sauder photo-allergic contact dermatitis, Deleo and Toback occupational skin disease, Tucker pemphigus, Anhalt et al bullous pemphigoid, Gammon cicatrical and localized pemphigoid, Fine herpes gestationis, Lawley and Yancey epidermolysis bullosa acquisita, Woodley et al dermatitis herpetiformis, Zone linear IgA bullous dermatosis and chronic bullous dermatosis of childhood, Bean lurpus erythematosus, Sontheimer and Provost dermatomyositis, Callen systemic scleroderma localized scleroderma, mixed connective tissue disease, Meurer et al cutaneous manifestations of Sjogren's syndrome, Alexander and Provost relapsing polychondritis, Rapini vitiligo, Drucker et al alopecia areata, Hordinsky necrotizing vasculitis, Sams henoch-sconlein purpura, Hall erythema multiforme, Huff and Brice erythema nodosum and gyrate erythemas, Troy and Goetz pyoderma gangrenosum/Sweet's syndrome, Jackson and Duvic drug reactions, Wintraob and Stern cutaneous complications of immunosuppressive therapy, Hood and Kwan grat-versus-host disease, Hymes et al chemically-induced granuloma formation, Epstein and Fukuyama malignant melanoma, Bystryn and Otatz cutaneous T-Cell lymphomas, Edelson and Vejlsgaard venereal diseases - syphilis, gonococcal infections, chancroid lymphogranuloma venereum and granuloma inguinale, Jorizzo and McNeely leprosy, Rea papillomavirus infection, Lowy immunologic features of psoriasis, Cooper and Baadsgaard lichen planus, Ziegler.
Direct synthesis of tubular bandpass filters with frequency-dependent inductors (2002)

A method for direct synthesis of a tubular filter with thin-film frequency-dependent lumped element resonators is presented. The synthesis procedure is developed with frequency-dependent inductors to accommodate a large parameter aspect ratio in compact configurations. The explicit design equations are derived from required coupling coefficients among resonators, which provide a great flexibility in choosing design parameters. A design example of a 4th order bandpass filter using high-temperature superconductor (HTS) thin-film material is shown which has a 0.6% fractional bandwidth, a less than 0.2 dB insertion loss and a 20 dB return loss. Experimental data show a good agreement with simulation performance. The technique is especially useful for designing ultra-narrowband filters where the proper coupling is difficult to achieve.
Benzyne reaction. IX. Benzyne reaction of o-halobenzenes with acetonitrile or phenylacetonitrile in organic solvents (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBenzyne reaction. IX. Benzyne reaction of o-halobenzenes with acetonitrile or phenylacetonitrile in organic solventsTetsuji Kametani, Kazuo Kigasawa, Mineharu Hiiragi, T. Aoyama, and Osamu KusamaCite this: J. Org. Chem. 1971, 36, 2, 327–330Publication Date (Print):January 1, 1971Publication History Published online1 May 2002Published inissue 1 January 1971https://pubs.acs.org/doi/10.1021/jo00801a018https://doi.org/10.1021/jo00801a018research-articleACS PublicationsRequest reuse permissionsArticle Views278Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Critically ill patients and fat emulsions. (1992)

In critically ill patients, lipid tolerance may be impaired. In ICU, patients are usually given TPN including fat emulsions. If sedation with propofol is given simultaneously the fat load increases and may exceed the maximal clearing capacity of exogenous fat emulsion unless the administration of the parenteral fat is adjusted to take account of the lipid contained in propofol. An accumulation of fat may result in the so-called 'fat overload syndrome'. Close monitoring of serum triglyceride concentration is therefore recommended to avoid fat overload.
Evaluation of transthoracic electrical impedance in the diagnosis of pulmonary edema. (1979)

To evaluate the clinical usefulness of measuring transthoracic electrical impedance in patients with pulmonary edema, we studied 27 normal subjects and 33 patients. In normal subjects, impedance increased when body position changed from supine to standing (p less than 0.01) and when lung volume increased from residual volume to total lung capacity (p less than 0.01). Impedance values vari7 omega) when measured hourly without removing the electrodes. In only five of 11 patients with clinically severe pulmonary edema and five of eight with radiologically severe pulmonary edema were impedance values outside the normal range. Changes in impedance values correlated with changes in clinical and radiographic indexes of pulmonary edema. We conclude that (1) single measurements of impedance are useless in diagnosing pulmonary edema, and (2) impedance changes as predicted as pulmonary edema increases and decreases, and these changes are readily detected by simpler methods of evaluation.
Electrokinetic Energy Conversion in Ultrafine Capillaries (1965)

Energy conversion utilizing the electrokinetic effect associated with the flow of an electrolyte through ultrafine capillary tubes is investigated analytically. This represents an extension of previous work by one of the authors to capillaries of fineness such that the Debye length is an appreciable fraction of the radius. In addition to this extension, a model for surface conductivity, not considered in the earlier work but important for ultrafine capillaries, is proposed and its effect on conversion efficiency considered. By numerical integration of the Poisson—Boltzmann equation governing the radial potential distribution in the tubes for the case of pure water in glass capillaries, results are obtained for the surface conductivity and maximum conversion efficiency as a function of capillary radius.
Modulation of Aβ42low-n oligomerization using a novel yeast reporter system (2006)

Previous models of Alzheimer's disease focused on unravelling compounds that inhibit fibrillization of Abeta42, i.e. the last step of Abeta42 assembly. However, inhibition of fibrillization may lead to the accumulation of toxic oligomers of Abeta42. The model described here can be used to search for and test proteinacious or chemical compounds for their ability to interfere with the initial steps of Abeta42 oligomerization. Our findings suggest that yeast contain guanidine-sensitive factor(s) that reduce the amount of low-n oligomers of Abeta42. As many yeast proteins have human homologs, identification of these factors may help to uncover homologous proteins that affect Abeta42 oligomerization in mammals.
Imaging of Backscattered Ionizing Radiation - A Key Enabler for through Mud Borehole Imaging (2011)

Abstract Current technology offers the operators of well-intervention equipment little opportunity to receive accurate and real-time visual feedback from the borehole when the fluid contents are opaque. As a result, the majority of operations are performed 'blind' leading to extensive use of time and increased risk of material damages. In extreme cases, and in the pursuit of a clear image the well's contents must be displaced and replaced with fluids that offer better visibility for video cameras at the possible expense of well integrity. Previous work within the field of borehole imaging has focused upon optical cameras, ultrasound and millimeter-wave technologies. Ionizing radiation is not perturbed by the optical opacity of the well contents or refracted and distorted by flowing fluids. The paper provides detailed results of data gathered from laboratory and field testing. In addition, the paper illustrates images of objects located in a drilling-fluid-filled well. The information provided offers an overview of a new technology and method, which solves the issues surrounding in-hole imaging of infrastructure, well-integrity inspection, and lost or stuck items without the need to displace the well contents. An overview of the development efforts involving the creation of a borehole tool which aims to solve the issue of through mud imaging, or imaging in a producing well without the need to displace the current contents to an optically clear fluid. The paper gives an overview of the steps necessary to mitigate the risk of such a development project, and an overview of the most important lessons learned. Imaging of backscattered ionizing radiation can find applications within well integrity inspection, perforation inspection, well auditing and the location and orientation of lost or stuck items within the borehole. Introduction One of the major financial concerns voiced by the drilling industry is lost time due to unplanned events such as items lost or stuck downhole in addition to well integrity issues. A number of companies have launched a series of major initiatives that have seen the number of such incidents fall substantially; however, the problem has not been completely possible to eradicate (Fowler, 1996). Drill string or a downhole tool stuck in a well can prove to be expensive, not only due to possible material damages but due to lost time. Not only are the increasingly sophisticated array of downhole tools and the time lost using them costly, but also the inability to retrieve them could realistically result in the loss of a well. A common precursor to a fishing expedition is lowering a lead block into the hole and taking an impression of the end of the fish to give the engineers some idea about the best fishing tool to select in order to remove the snapped drill strings or other items. The problem is, however, there is still a distinct challenge in interpreting these impressions and unless the identity is obvious, the impression can be discarded (Walker, 1984).
Streaming Video Capacities of LTE Air-Interface (2010)

The 3GPP Long Term Evolution (LTE) systems have been designed to deliver higher peak data rates, higher capacity and lower air-interface latency compared to prior 2G and 3G systems. This high performance will make it possible to support more demanding applications beyond web browsing and voice, which will require higher data rates and QoS guarantees. Video services are becoming very popular over the Internet. With the wide deployment of LTE in the near future, the demand for high data-rate video applications over cellular wireless will grow. However, in order to make these services commercially viable, it is necessary that the LTE air-interface can deliver high quality services to a sizeable number of users simultaneously. In this paper we investigate the downlink video capacities of the LTE air-interface by dynamic system simulation using realistic video traffic models and detailed models of the LTE air-interface. We investigate how video quality and system outage criteria impact the air-interface video capacities and describe observations on video stream quality and operator revenue under certain cost assumptions.
Limitations of mammography in the identification of noninfiltrating carcinoma of the breast. (1988)

A retrospective study of 321 patients who underwent localizing mammography and excisional biopsy of the breast from 1984 to 1985 was performed. The study was undertaken to refine selection criteria for biopsy in women with nonpalpable mammographic abnormalities by comparing mammographic features and impression with histologic findings. Twenty-eight of 36 (78 per cent) noninfiltrating carcinomas presented with microcalcifications alone; in contrast, 27 of 39 (69 per cent) infiltrating carcinomas presented with a mass alone. As the number of microcalcifications increased, so did the incidence of carcinoma. The size of the mass was not a guide for predicting carcinoma. Although only 11 of 75 carcinomas presented as a mass with microcalcifications, 11 of 21 calcified masses were carcinoma. There were no significant differences in the mammographic presentation between ductal and lobular carcinoma. The sensitivity of the mammographic impression was 48/75 (0.64), and the specificity was 221/246 (0.898). The false-positive rate was 25/73 (0.34), and the false-negative rate was 10/141 (0.07). From this study, we concluded 1, the incidence of noninfiltrating carcinoma was significantly higher and the incidence of positive nodes was significantly lower in nonpalpable abnormalities than in palpable masses; 2, noninfiltrating carcinomas were generally associated with microcalcifications alone, but infiltrating carcinomas were generally associated with a mass alone, and 3, the diagnostic accuracy of mammography was limited by under-interpretation of the subtler signs of noninfiltrating carcinoma and by over-interpretation of mammographic findings generally accepted as criteria for carcinoma.
Localization of disinhibition-dementia-parkinsonism-amyotrophy complex to 17q21-22. (1994)

Disinhibition-dementia-parkinsonism-amyotrophy complex (DDPAC) is defined by familial adult-onset behavioral disturbance, followed by frontal lobe dementia, parkinsonism, and amyotrophy in variable proportions. A genetic etiology of DDPAC was suspected because of the familial clustering in family Mo, despite their wide geographic distribution. We have mapped the DDPAC locus to a 12-cM (sex averaged) region between D17S800 and D17S787 on chromosome 17q21-22. The basis for the variability of the clinical findings and pathology in DDPAC is unknown but suggests that the DDPAC locus should be screened as a candidate locus in family studies of conditions with behavioral abnormalities and neurological degeneration.
Treatment of malignant effusion by oncolytic virotherapy in an experimental subcutaneous xenograft model of lung cancer (2013)

Here, we demonstrate for the first time that oncolytic virotherapy using tumor-specific Vaccinia virus represents a novel and promising treatment modality for therapy of ME associated with advanced lung cancer.
Susceptibility of oral bacterial biofilms to antimicrobial agents (1996)

There is great interest in the use of antimicrobial agents for the prevention and treatment of plaque-related oral diseases and many publications have reported the results of studies in which the minimum inhibitory concentrations of agents for cariogenic and periodontopathogenic bacteria have been determined. However, such data are relevant only to situations where the organisms of interest are in aqueous suspension, whereas in caries and the inflammatory periodontal diseases the target organisms are in the form of biofilms. On the basis of studies with medically important bacteria, it has been established that bacteria in biofilms are invariably less susceptible to antimicrobial agents than their planktonic counterparts. Therefore, in the laboratory assessment of agents which may be suitable for treating plaque-related diseases, the target organisms should be in the form of biofilms. While laboratory evaluation of chemical agents for the prevention of plaque formation has usually employed biofilm-based models, the search for antimicrobial agents effective in the treatment of plaque-related diseases has not. Therefore, there are few data available regarding those characteristics of antimicrobial agents (e.g., their biofilm eliminating concentrations or biofilm killing concentrations) that could be used to judge their suitability for treating plaque-related diseases. In this review the limited information available concerning the antimicrobial susceptibility of oral bacteria in biofilms is presented.
Piezoelectric Actuators for Low-Form-Factor Electronics Cooling (2005)

The cooling performance of piezoelectric actuators is evaluated for low-form-factor electronics in this work. A piezoelectric actuator is a cantilever made from metal or plastic with a piezoelectric material bonded to it. Under an alternating electrical current, the piezo actuator oscillates back and forth, generating airflow. Compared to conventional fans, these actuators have the advantages of low power consumption, low noise, and smaller dimensions. The parameters investigated in the experiments are actuator orientation, actuator-to-heat source distance, and actuator amplitude. For an actuator power consumption of 31 mW, the heat source temperature was lowered by more than 25°C compared to natural convection conditions (for a 2.45 W heater power dissipation). Performance comparisons against axial fans and natural convection heat sinks show that the piezo actuators perform significantly better in terms of power consumption and cooling volume. This paper was also originally published as part of the Proceedings of the ASME 2005 Heat Transfer Summer Conference.
Joint MAP equalization and channel estimation for frequency-selective and frequency-flat fast-fading channels (2001)

This paper presents a new fractionally-spaced maximum a posteriori (MAP) equalizer for data transmission over frequency-selective fading channels. The technique is applicable to any standard modulation technique. The MAP equalizer uses an expanded hypothesis trellis for the purpose of joint channel estimation and equalization. The fading channel is estimated by coupling minimum mean square error techniques with the (fixed size) expanded trellis. The new MAP equalizer is also presented in an iterative (turbo) receiver structure. Both uncoded and conventionally coded systems (including iterative processing) are studied. Even on frequency-flat fading channels, the proposed receiver outperforms conventional techniques. Simulations demonstrate the performance of the proposed equalizer.
Profiling Gene Expression During the Differentiation and Development of the Murine Embryonic Gonad1 (2004)

The application of microarray technology to the study of mammalian organogenesis can provide greater insights into the steps necessary to elicit a functionally competent tissue. To this end, a temporal profile of gene expression was generated with the purpose of identifying changes in gene expression occurring within the developing male and female embryonic gonad. Gonad tissue was collected from mouse embryos at 11.5, 12.5, 14.5, 16.5, and 18.5 days postcoitum (dpc) and relative steady-state levels of mRNA were determined using the Affymetrix MGU74v2 microarray platform. Statistical analysis produced 3693 transcripts exhibiting differential expression during male and/or female gonad development. At 11.5 dpc, the gonad is morphologically indifferent, but at 12.5 dpc, transitions to a male or female phenotype are discernible by the appearance of testicular cords. A number of genes are expressed during this period and many share similar expression profiles in both sexes. As expected, the expression of two well-known sex determination genes, specifically Sry and Sox9, is unique to the testis. Beyond 12.5 dpc, differential gene expression becomes increasingly evident as the male and female tissue morphologically and physiologically diverges. This is evident by two unique waves of transcriptional activity occurring after 14.5 dpc in the male and female. With this study, a large number of transcripts comprising the murine transcriptome can be examined throughout male and female embryonic gonad development and allow for a more complete description of gonad differentiation and development.
Fluorescence and bioluminescence measurement of cytoplasmic free calcium (1987)

+; BAPTA, 1,2-bis-(2-aminophenoxy)ethane-NNN'N'-tetra-acetic
Towards a critical practice for the academic library (1996)

Considers how information provision in academic libraries is affected as higher education is increasingly subject to free market principles. Examines how research tailored for commerce and industry can limit research in other fields. Looks at how increased competition between universities leads to a narrowing of the journal base for research assessment. Notes that current practice in academic libraries takes no account of these trends, and highlights deficiencies in user education which emphasize training over education in critical inquiry. Focuses on the latter as the basis of a critical practice for the academic library, and examines ways in which academic librarianship might be transformed to take account of the limits on information flow necessitated by the free market.
A glycosylphosphatidylinositol (GPI)-negative phenotype produced in Leishmania major by GPI phospholipase C from Trypanosoma brucei: topography of two GPI pathways (1994)

The major surface macromolecules of the protozoan parasite Leishmania major, gp63 (a metalloprotease), and lipophosphoglycan (a polysaccharide), are glycosylphosphatidylinositol (GPI) anchored. We expressed a cytoplasmic glycosylphosphatidylinositol phospholipase C (GPI-PLC) in L. major in order to examine the topography of the protein-GPI and polysaccharide-GPI pathways. In L. major cells expressing GPI-PLC, cell-associated gp63 could not be detected in immunoblots. Pulse-chase analysis revealed that gp63 was secreted into the culture medium with a half-time of 5.5 h. Secreted gp63 lacked anti-cross reacting determinant epitopes, and was not metabolically labeled with [3H]ethanolamine, indicating that it never received a GPI anchor. Further, the quantity of putative protein-GPI intermediates decreased approximately 10-fold. In striking contrast, lipophosphoglycan levels were unaltered. However, GPI-PLC cleaved polysaccharide-GPI intermediates (glycoinositol phospholipids) in vitro. Thus, reactions specific to the polysaccharide-GPI pathway are compartmentalized in vivo within the endoplasmic reticulum, thereby sequestering polysaccharide-GPI intermediates from GPI-PLC cleavage. On the contrary, protein-GPI synthesis at least up to production of Man(1 alpha 6)Man(1 alpha 4)GlcN-(1 alpha 6)-myo-inositol-1-phospholipid is cytosolic. To our knowledge this represents the first use of a catabolic enzyme in vivo to elucidate the topography of biosynthetic pathways. GPI-PLC causes a protein-GPI-negative phenotype in L. major, even when genes for GPI biosynthesis are functional. This phenotype is remarkably similar to that of some GPI mutants of mammalian cells: implications for paroxysmal nocturnal hemoglobinuria and Thy-1-negative T-lymphoma are discussed.