gebhart/patrepeval huggingface dataset:
Three‐dimensional mapping of the static magnetic field inside the human head (1996)

Finite element analysis was used to calculate the static magnetic field within the three-dimensional head model. Localized field distributions were evaluated by using the magnetic field histogram technique. Experimental field maps and histograms of the human head were also obtained to validate the simulation results. Field deviations and gradients inside the human head cause NMR signal frequency shifts and line broadening, respectively. Voxels 2 x 2 x 0.5 cm may have frequency differences of more than 2.0 ppm. The linewidth of a single voxel may be broadened by more than 0.5 ppm. Calculated and experimental field maps are in excellent agreement. The global field distortion in the human head is primarily due to the susceptibility difference between air and tissues and their corresponding geometrical shapes.
Cellular Telecommunications at Amtrak's Worst Crash (1987)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the 'Save PDF' action button.
Thirteen new players in the team (2010)

We demonstrate an efficient LINQ to SQL provider and its significant impact on the runtime performance of LINQ programs that process large data volumes. This alternative provider is based on Ferry, compilation technology that lets relational database systems participate in the evaluation of first-order functional programs over nested, ordered data structures. The Ferry-based provider seamlessly hooks into the .NET LINQ framework and generates SQL code that strictly adheres to the semantics of the LINQ data model. Ferry comes with strong code size guarantees and complete support for the LINQ Standard Query Operator family, enabling a truly interactive and compelling LINQ demonstration. A variety of inspection holes may be opened to learn about the internals of the Ferry-based LINQ to SQL provider.
Neurofibrillary Tangles Mediate the Association of Amyloid Load With Clinical Alzheimer Disease and Level of Cognitive Function (2004)

These findings are consistent with a sequence of pathologic events whereby the effect of amyloid deposition on clinical disease is mediated by neurofibrillary tangles.
γ-Secretase Inhibition Reduces Spine Density<i>In Vivo</i>via an Amyloid Precursor Protein-Dependent Pathway (2009)

Alzheimer's disease (AD) represents the most common age-related neurodegenerative disorder. It is characterized by the invariant accumulation of the beta-amyloid peptide (Abeta), which mediates synapse loss and cognitive impairment in AD. Current therapeutic approaches concentrate on reducing Abeta levels and amyloid plaque load via modifying or inhibiting the generation of Abeta. Based on in vivo two-photon imaging, we present evidence that side effects on the level of dendritic spines may counteract the beneficial potential of these approaches. Two potent gamma-secretase inhibitors (GSIs), DAPT (N-[N-(3,5-difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester) and LY450139 (hydroxylvaleryl monobenzocaprolactam), were found to reduce the density of dendritic spines in wild-type mice. In mice deficient for the amyloid precursor protein (APP), both GSIs had no effect on dendritic spine density, demonstrating that gamma-secretase inhibition decreases dendritic spine density via APP. Independent of the effects of gamma-secretase inhibition, we observed a twofold higher density of dendritic spines in the cerebral cortex of adult APP-deficient mice. This observation further supports the notion that APP is involved in the modulation of dendritic spine density--shown here for the first time in vivo.
The ‘yellow brick road’ to branched complex <i>N</i>-glycans (1991)

Journal Article The 'yellow brick road' to branched complex N-glycans Get access Harry Schachter Harry Schachter Research Institute, Hospital for Sick Children, and Department of Biochemistry, University of TorontoToronto, Ontario, M5G 1X8, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Glycobiology, Volume 1, Issue 5, November 1991, Pages 453–461, https://doi.org/10.1093/glycob/1.5.453 Published: 01 November 1991 Article history Received: 02 August 1991 Accepted: 30 August 1991 Published: 01 November 1991
Natural human interferon-α2 is <i>O</i>-glycosylated (1991)

Natural human interferon alpha 2 (IFN-alpha 2) was isolated from a preparation of partially purified human leucocyte IFN by monoclonal-antibody immunoaffinity chromatography. The purified protein had a specific activity of 1.5 x 10(8) i.u./mg; it was estimated to constitute 10-20% of the total antiviral activity of leucocyte IFN. N-Terminal amino-acid-sequence analysis identified the subspecies IFN-alpha 2b and/or IFN-alpha 2c, whereas IFN-alpha 2a was not detectable. The structure of natural IFN-alpha 2 was found to differ from that of its recombinant (Escherichia coli-derived) equivalent. First, reverse-phase h.p.l.c. showed that natural IFN-alpha 2 was significantly more hydrophilic then expected. Secondly, the apparent molecular mass of the natural protein determined by SDS/PAGE was higher than that of recombinant IFN-alpha 2; incubation under mild alkaline conditions known to eliminate O-linked carbohydrates resulted in a reduction of the apparent molecular mass to that of the recombinant protein. On sequence analysis of proteolytic peptides, Thr-106 was found to be modified. These results suggested that Thr-106 of natural IFN-alpha 2 carries O-linked carbohydrates. Reverse-phase h.p.l.c. as well as SDS/PAGE of natural IFN-alpha 2 showed that glycosylation is heterogeneous. For characterization of the carbohydrate moieties, the protein was treated with neuraminidase and/or O-glycanase and analysed by gel electrophoresis; in addition, glycopeptides obtained by proteinase digestion and separated by h.p.l.c. were characterized by sequence analysis and m.s. Further information on the composition of the glycans was obtained by monosaccharide analysis. The results indicate that natural IFN-alpha 2 contains the disaccharide galactosyl-N-acetylgalactosamine (Gal-GalNAc) linked to Thr-106. In part of the molecules, this core carbohydrate carries (alpha-)N-acetylneuraminic acid, whereas a disaccharide, probably N-acetyl-lactosamine, is bound to Gal-GalNAc in another proportion of the protein. Further glycosylation isomers are present in small amounts. As IFN-alpha 2 is the only IFN-alpha species with a threonine residue at position 106, it may represent the only O-glycosylated human IFN-alpha protein.
Powder Metallurgy Stainless Steels Applications (2015)

Abstract This article describes the physical properties of powder metallurgy (PM) stainless steels. These include thermal diffusivity, conductivity, thermal expansion coefficient, Poisson's ratio, and elastic modulus. The article contains a table that lists the characteristics of various grades of PM stainless steels. It discusses the applications of various PM stainless steels such as rearview mirror brackets, anti-lock brake system sensor rings, and automotive exhaust flanges and sensor bosses.
Structure of Pna-Nucleic Acid Complexes (1997)

Abstract The solution structure of the PNA-DNA hybrid H-GCTATGTC-NH2d(GACATAGC), determined by NMR methods, shows a new conformation which has elements of both A- and B-form DNA. Comparison with other PNA-nucleic acid complexes points to common structural features, but also demonstrates the ability of PNA to conform to nucleic acid partners of different conformations.
OAuth Based Authentication and Authorization in Open Telco API (2012)

Open Telco APIs to 3rd party application and content providers will enhance the services available to the Web and facilitate the creation of more innovative applications and content. However, open Telco APIs directly to Internet makes the operator's network vulnerable to security threats. To prevent fraudulent users to get access to the network asset, the authentication and authorization of the APIs is necessary. This paper analyzes different authentication and authorization mechanism, provides guidelines for open Telco API authentication and authorization, and gives a solution to apply OAuth based authentication and authorization in open Telco API.
Immobilized β-Cyclodextrins. Preparation with Various Crosslinking Reagents and the Guest Binding Properties (1989)

Abstract β-Cyclodextrin (β-CyD) was immobilized by crosslinking with 1,2-ethanediol diglycidyl ether, 1,4-buthanediol diglycidyl ether, 1,6-hexanediol diglycidyl ether, 1,3-butadiene diepoxide, 1,7-octadiene diepoxide, and epichlorohydrin. The molar ratio of the crosslinking residue to β-CyD (degree of crosslinking) for each macromolecular product was determined by the corresponding elemental analysis. The equilibrium constant K of complex formation of each crosslinking macromolecule for cresols, phenol, nitrophenols, and 2-naphthol was determined, respectively, by the use of electronic absorption spectroscopy in pH 4 and 10 (or 11) buffer solutions. The concept of a hydrophobic enhancement coefficient R was introduced in order to compare the effect of a hydrophobic crosslinking residue upon the complex formation of the immobilized CyD.
Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds (2017)

The design of proteolysis-targeting chimeras (PROTACs) is a powerful small-molecule approach for inducing protein degradation. PROTACs conjugate a target warhead to an E3 ubiquitin ligase ligand via a linker. Here we examined the impact of derivatizing two different BET bromodomain inhibitors, triazolodiazepine JQ1 and the more potent tetrahydroquinoline I-BET726, via distinct exit vectors, using different polyethylene glycol linkers to VHL ligand VH032. Triazolodiazepine PROTACs exhibited positive cooperativities of ternary complex formation and were more potent degraders than tetrahydroquinoline compounds, which showed negative cooperativities instead. Marked dependency on linker length was observed for BET-degrading and cMyc-driven antiproliferative activities in acute myeloid leukemia cell lines. This work exemplifies as a cautionary tale how a more potent inhibitor does not necessarily generate more potent PROTACs and underscores the key roles played by the conjugation. The provided insights and framework for structure-activity relationships of bivalent degraders are anticipated to have wide future applicability.
The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin (1997)

This study was designed to assess the role of G-proteins and protein kinases in the spinal cord in the behavioral manifestations induced by intradermal injection of capsaicin in rats. A microdialysis fiber was implanted in the spinal cord dorsal horn for administration of G-protein and protein kinase inhibitors to decipher the role of signal transduction cascades in mechanical allodynia induced by intradermal injection of capsaicin. Animals were tested for responses to graded mechanical stimuli using von Frey filaments and for responses to radiant heat stimuli outside the area of injection. The present study demonstrated that intradermal injection of capsaicin results in changes consistent with secondary mechanical allodynia without secondary heat hyperalgesia. Infusion of a G-protein inhibitor (GDP-beta-S), a general protein kinase inhibitor (H7), or selective inhibitors of protein kinase C (NPC15437), protein kinase A (H89), or protein kinase G (KT5823) into the spinal cord dorsal horn reversed the mechanical allodynia induced by intradermal injection of capsaicin in a dose-dependent manner by increasing the threshold to mechanical stimulation towards baseline. This suggests that multiple signal transduction pathways in the spinal cord are involved in the secondary allodynia that occurs following activation of C-fiber afferents by capsaicin.
An isoleucine zipper peptide forms a native-like triple stranded coiled coil in solution (1998)

Recent studies in the field of de novo protein design have focused on the construction of native-like structures. Here we describe the design and characterization of an isoleucine zipper peptide intended to form a parallel triple-stranded coiled coil. To obtain the native-like structural uniqueness, the hydrophobic interface of the peptide consists of beta-branched Ile residues for complementary side chain packing. The peptide forms a stable triple-stranded coiled coil, as determined by circular dichroism and sedimentation equilibrium analyses. A fluorescence quenching assay after the incorporation of acridine revealed a parallel orientation of the peptides. The structural uniqueness of the coiled coil was confirmed by proton-deuterium amide hydrogen exchange and hydrophobic dye binding. The peptide contains amide protons with hydrogen exchange rates that are approximately an order of magnitude slower than those expected if the exchange occurred via global unfolding. A hydrophobic dye does not bind to the peptide. These results strongly suggest that the peptide folds into a well-packed structure that is very similar to the native state of a natural protein. Thus, Ile residues in the hydrophobic interface can improve the side chain packing, which can impart native-like structural uniqueness to the designed coiled coil.
Pricing and Charging for QoS (2005)

We have introduced and studied a scalable pricing scheme as an effective regulatory tool that provides proper incentives so that users' self-interest will lead them to modify their usage according to their needs. This scheme resulted in better overall network utilization and enhanced users' satisfaction. In this work, we further study the scheme from revenue and performance perspective. Simulation results suggest that revenue and network utilization play a vital role in achieving a better usage behavior as well as for service providers to be reasonable in charging for QoS in Internetworks. The implementation and usage costs of the framework are low
Experimental evidence for the existence of polycarbon oxide sulfides O(Cn)S (n = 3-5) in the gas phase (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExperimental evidence for the existence of polycarbon oxide sulfides O(Cn)S (n = 3-5) in the gas phaseDetlev Suelzle and Helmut SchwarzCite this: J. Am. Chem. Soc. 1991, 113, 1, 48–51Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/ja00001a009https://doi.org/10.1021/ja00001a009research-articleACS PublicationsRequest reuse permissionsArticle Views43Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Organic–Inorganic Nanostructured Colloids (2002)

The synthesis and applications of organic-inorganic nanostructured colloids and colloidal-based materials are reviewed here. Emphasis is placed on the strategies and synthetic methods developed to organize organic-inorganic architectures. The article begins with a description and a general hierarchical classification of different systems, from inorganic particle synthesis and surface modification to more elaborate nanostructured colloids obtained through in situ encapsulation and/or self-assembly techniques. Ordering of colloids into two- and three-dimensional arrays and their use as templates is also considered. For every system, typical examples are given that highlight the advantages and limitations of the techniques, as are more recent developments. Some properties and applicability of organic-inorganic colloids in catalysis, medicine, and coating technologies are also cited.
OPTICS (1999)

Cluster analysis is a primary method for database mining. It is either used as a stand-alone tool to get insight into the distribution of a data set, e.g. to focus further analysis and data processing, or as a preprocessing step for other algorithms operating on the detected clusters. Almost all of the well-known clustering algorithms require input parameters which are hard to determine but have a significant influence on the clustering result. Furthermore, for many real-data sets there does not even exist a global parameter setting for which the result of the clustering algorithm describes the intrinsic clustering structure accurately. We introduce a new algorithm for the purpose of cluster analysis which does not produce a clustering of a data set explicitly; but instead creates an augmented ordering of the database representing its density-based clustering structure. This cluster-ordering contains information which is equivalent to the density-based clusterings corresponding to a broad range of parameter settings. It is a versatile basis for both automatic and interactive cluster analysis. We show how to automatically and efficiently extract not only 'traditional' clustering information (e.g. representative points, arbitrary shaped clusters), but also the intrinsic clustering structure. For medium sized data sets, the cluster-ordering can be represented graphically and for very large data sets, we introduce an appropriate visualization technique. Both are suitable for interactive exploration of the intrinsic clustering structure offering additional insights into the distribution and correlation of the data.
Increasing Volume of Distribution to the Brain with Interstiti; Infusion: Dose, Rather Than Convection, Might Be the Most Important Factor (1996)

THE VOLUME OF distribution in tissue (Vt) that can be achieved by direct interstitial infusion of therapeutic agents into brain is limited. The maintenance of a pressure gradient during interstitial infusion to establish fluid convection has been shown to increase theVt of small, medium, and large molecules. We have used monocrystalline iron oxide nanocompounds, superparamagnetic particles of sizes the same order of magnitude as virions, to investigate the effect of dose, the volume of infusate, and the time of infusion on the distribution of large molecules in rodent brain. Our initial study in rats (n = 6) replicated the results of a previously described report of convection-enhanced delivery in cats. At a constant rate and concentration, the Vt increased in a linear fashion, proportional to the increases in time, volume, and dose. When using a constant rate and a constant concentration, however, it is unclear which variable or variables (dose, volume, infusion time) have the greatest influence on this effect. Therefore, we assessed each variable independently (n = 12). When the iron dose was increased from 5.3 to 26.5μg, there was a three- to fivefold increase in the Vt, depending on the volume and time of infusion (2 μl/20 min, 24 μl/20 min, or 24 μl/120 min) (P < 0.001). When the volume of infusate was increased from 2 to 24 μl, at an infusion time of 20 minutes and a dose of either 5.3 or 26.5 μg, there was a 43 or 52% decline in theVt, respectively (P = 0.018). When the time for the infusion of 24 μl was increased from 20 to 120 minutes, there was a 79% increase in the Vt at a dose of 26.5 μg but no change in the Vt at a dose of 5.3 μg. The effect associated with infusion time was not significant (P = 0.113). Magnetic resonance imaging was performed to document the distribution of monocrystalline iron oxide nanocompounds in vivo, and histochemical staining for iron was used to document the distribution of monocrystalline iron oxide nanocompounds in tissue sections. The Vt for both methods was calculated by computer image analysis, and the correlation between magnetic resonance and histological volumes was determined (r2 = 0.93). On the basis of this model, we suggest that dose, rather than convection, might be the most important variable in maximizing the Vt and improved distribution might be achieved by administering an increased concentration of agent.
MicroRNA-21 is involved in ionizing radiation-promoted liver carcinogenesis. (2010)

It has been known for decades that ionizing radiation (IR) promotes carcinogenesis and high-linear energy transfer (LET) IR has a higher risk than low-LET IR for carcinogenesis; however, the mechanism remains unclear. MicroRNAs (miRNAs) have a critical effect on carcinogenesis through post-transcriptional modification. In this study, our purpose is to explore whether miRNAs are involved in IR-(especially high-LET IR) promoted liver carcinogenesis. We showed here that among several hundred miRNAs, miR-21 was the only one that increased 6 folds in high-LET IR-promoted mouse liver tumors when compared with that in the non-irradiated liver tissues. We also showed that miR-21 was up-regulated in human or mouse hepatocytes after exposure to IR, as well as in liver tissues derived from whole body irradiated mice. The increased level of miR-21 was more significant in high-LET irradiated cells or liver tissues. After the non-irradiated, low-LET or high-LET irradiated human hepatocytes were over-expressed with miR-21, these cells became tumorigenesis in nude mice. The tumors derived from high-LET-irradiated-cells were largest, and accompanied by more significant changes in the miR-21-targets: PTEN and RECK. In addition, we showed that IR-induced up-regulation of miR-21 depended on the up-regulation/activation of AP-1 (at an earlier time, within 2 h) and the ErbB/Stat3 pathway (at a later time, more than 2 h), which was also IR dose dependent. Taken together, we conclude that IR-induced up-regulation of miR-21 plays an important role in IR (especially high-LET IR)-promoted liver carcinogenesis.
Decorrelation of Troposphere Across Short Baselines (2006)

The performance of GNSS RTK systems is strongly dependent on spatial correlation of tropospheric errors. However, normal storm activity can cause conditions where tropospheric delays can be significantly different even across relatively short baselines. In this paper, the decorrelation of tropospheric delay over short baselines (2 to 10 km) is investigated. Data from pairs of CORS stations as well as independently collected data are used to derive double- difference phase residuals for L1 and L2 measurements. The known coordinates of the ends of the baseline are accounted for in the calculation of the residuals to provide a measurement of double-difference phase errors. Multipath contributions to the phase errors are minimized by comparing data collected on consecutive days. Tropospheric effects are isolated from ionospheric effects by looking for signatures unique to the troposphere. One such signature is the relative magnitude of the L1 and L2 residuals. A second signature is correlation with local weather data and absence of correlation with ionospheric activity. A strong correlation is seen between storm activity shown on local weather radar and high residuals. Residuals attributed to the troposphere equivalent to at least 12 parts per million for overhead satellites are observed across short baselines.