gebhart/patrepeval huggingface dataset:
Genetic Relationships among Soybean Plant Introductions for Resistance to Race 3 of Soybean Cyst Nematode (1988)

Soybean cyst nematode (SCN), Heterodera glycines Ichinohe, is a major pest of soybean, Glycine max L. Merr. Several plant introductions resistant to Race 3 have been identified, however the genetic relationships for resistance among them are not known. The F 2 plants and F 3 families from seven different crosses involving resistant parents were evaluated in the greenhouse to determine if the genes for resistance were identical or different from the genes in ‘Peking’ and/or PI 90763. Each seedling was inoculated with 1000 eggs and juveniles of SCN Race 3. Plant roots were washed after 30 d and white females enumerated. Based on the index of parasitism (IP) F 2 plants and F 3 families were categorized into resistant, segregating, or susceptible. The Chi‐square test was applied to determine goodness of fit between the observed and expected genetic ratios. Peking was found to have genes in common with PI 90763 and PI 438489B; whereas PI 90763 has genes in common with PI 438489BP, PI 404166, and PI 404198A. The cross between Peking and PI 88788 indicated segregation for one dominant and one recessive gene, and segregation in the cross PI 88788 × PI 438496B suggested two independent dominant genes. This information will assist soybean breeders in choosing additional resistant sources to SCN Race 3 in commercial cultivar development, thus providing a broader genetic base.
Post-transcriptional regulation of nitrate reductase by light is abolished by an N-terminal deletion. (1995)

Higher plant nitrate reductases (NRs) carry an N-terminal domain whose sequence is not conserved in NRs from other organisms. A gene composed of a full-length tobacco NR cDNA with an internal deletion of 168 bp in the 5' end fused to the cauliflower mosaic virus 35S promoter and appropriate termination signals was constructed and designated as delta NR. An NR-deficient mutant of Nicotiana plumbaginifolia was transformed with this delta NR gene. In transgenic plants expressing this construct, NR activity was restored and normal growth resulted. Apart from a higher thermosensitivity, no appreciable modification of the kinetic parameters of the enzyme was detectable. The post-transcriptional regulation of NR by light was abolished in delta NR transformants. Consequently, deregulated production of glutamine and asparagine was detected in delta NR transformants. The absence of in vitro delta NR activity modulation by ATP suggests the impairment of delta NR phosphorylation and thereby suppression of delta NR post-translational regulation. These data imply that post-transcriptional control of NR expression is important for the flow of the nitrate assimilatory pathway.
MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations (2016)

The anti-epidermal growth factor receptor (EGFR) antibodies cetuximab and panitumumab are used to treat RAS wild-type colorectal cancers (CRCs), but their efficacy is limited by the emergence of acquired drug resistance. After EGFR blockade, about 20% of CRCs develop mutations in the EGFR extracellular domain (ECD) that impair antibody binding and are associated with clinical relapse. We hypothesized that EGFR ECD-resistant variants could be targeted by the recently developed oligoclonal antibody MM-151 that binds multiple regions of the EGFR ECD. MM-151 inhibits EGFR signaling and cell growth in preclinical models, including patient-derived cells carrying mutant EGFR. Upon MM-151 treatment, EGFR ECD mutations decline in circulating cell-free tumor DNA (ctDNA) of CRC patients who previously developed resistance to EGFR blockade. These data provide molecular rationale for the clinical use of MM-151 in patients who become resistant to cetuximab or panitumumab as a result of EGFR ECD mutations.
Enhancement of mixing by droplet-based microfluidics (2003)

Enhancement of mixing using electrowetting-on-dielectric (EWOD) actuation is demonstrated. Exponential improvement over simple diffusion is theorized, based on convolutions generated by discrete droplet flow. The relationship between particle size, distance diffused, and diffusion time is studied. An improvement of 50 times over simple diffusion is experimentally shown, using a simple dye-mixing experiment.
Redox and Nitric Oxide-Mediated Regulation of Sensory Neuron Ion Channel Function (2014)

Since our understanding of ROS and RNS signaling in sensory neurons is limited, there is a multitude of future directions; one of the most important issues for further study is the establishment of the exact roles that these signaling pathways play in pain processing and the translation of this understanding into new therapeutics.
Melting temperature of the n-alkanes and the linear polyethylenes (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMelting temperature of the n-alkanes and the linear polyethylenesL. Mandelkern, A. Prasad, R. G. Alamo, and G. M. StackCite this: Macromolecules 1990, 23, 15, 3696–3700Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/ma00217a025https://doi.org/10.1021/ma00217a025research-articleACS PublicationsRequest reuse permissionsArticle Views636Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Radiation chemistry of polyethylene. X. Kinetics of the conversion of alkyl to allyl free radicals (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRadiation chemistry of polyethylene. X. Kinetics of the conversion of alkyl to allyl free radicalsD. C. Waterman and Malcolm DoleCite this: J. Phys. Chem. 1970, 74, 9, 1913–1922Publication Date (Print):April 1, 1970Publication History Published online1 May 2002Published inissue 1 April 1970https://pubs.acs.org/doi/10.1021/j100704a015https://doi.org/10.1021/j100704a015research-articleACS PublicationsRequest reuse permissionsArticle Views216Altmetric-Citations90LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A mesh-radio-based solution for smart metering networks (2012)

Propelled by the need to reduce the impact on the environment and improve energy efficiency, we see an impetus toward enabling a smart grid. One of the key constituents of the smart grid is the automated metering infrastructure, which is expected to facilitate the transport of meter readings from meters to the utility provider, and (potentially) control information in the other direction. A range of communication technologies are being considered for realizing AMI networks with no clear winner so far. This article provides an overview of some of the candidate solutions and proposes a mesh-radio based solution. The proposed solution is an enhanced version of the RPL protocol and exhibits self-organizing characteristics, and is practical and therefore attractive from a deployment perspective. Additionally, we also discuss network operational issues to improve robustness and scalability, as well as fault recovery due to link failure.
A real-time integrated traffic management scheme in ATM networks: design and simulation (2002)

This paper presents a RITM (real-time integrated traffic management) scheme that can effectively manage VBR (variable bit rate) and ABR (available bit rate) cell services having unpredictable characteristics in ATM (asynchronous transfer mode) networks. In addition to its exact traffic monitoring capability, the proposed scheme intends to efficiently use network resources without any deterioration in QoS (quality of service) of the accepted connections. Specifically, we highlight some functions of resource management, connection admission control that should be integrated to operated correctly in the emerging ATM networks. This enables ATM switch designers to find a suitable buffer design method. An unique feature of this scheme is that it has a special ATM cell control block, which makes it possible to manage ATM traffic in real-time so that the delay incurred to measure the cell arrival rate in existing algorithms is removed. By doing this, we can also save ATM switch buffers fairly, which means that those buffers would be used for more users or ABR services. This property makes the scheme extremely attractive for supporting most delay-sensitive and loss-sensitive applications at the same time without changing the existing ATM environments. The proposed RITM scheme has been verified to reliably monitor incoming traffic and to efficiently manage network resources by simulations.
Spatial Resolution in Digital Mammography (1993)

A relatively low spatial resolution of 0.1 mm/pixel does not prohibit high-quality diagnostic performance in digital mammography.
Safeguarding cryptographic keys (1979)

The following topics are dealt with: operating systems (computers); security of data; multiprocessing systems; software engineering; microprocessor chips; software maintenance; software metrics; relational databases; computer networks; storage management.
A quasi-matrix ferroelectric memory for future silicon storage (2002)

We proposed a new quasi-matrix ferroelectric memory for use in future silicon-storage media. The memory unit consists of multiple ferroelectric capacitors and one access transistor. Each capacitor stores 1 bit of data, and the access transistor is shared by several capacitors. Compared with conventional crosspoint matrix type FeRAMs, which cause a signal degradation by read/write disturbance, this memory limits the disturbing frequency to an acceptable level by accessing the memory unit as a whole. Crosstalk noise was also minimized by applying a unique access scheme. This memory has a scalability by adopting built-in sense circuits, and enables an extremely high packing density with three-dimensional multistacking structures of memory cells.
A Survey of Mid-Air Ultrasound Haptics and Its Applications (2020)

Ultrasound haptics is a contactless haptic technology that enables novel mid-air interactions with rich multisensory feedback. This article surveys recent advances in ultrasound haptic technology. We discuss the fundamentals of this haptic technology, how a variety of perceptible sensations are rendered, and how it is currently being used to enable novel interaction techniques. We summarize its strengths, weaknesses, and potential applications across various domains. We conclude with our perspective on key directions for this promising haptic technology.
Polymeric contrast agents for magnetic resonance imaging: synthesis and characterization of gadolinium diethylenetriaminepentaacetic acid conjugated to polysaccharides (1990)

The synthesis and characterization of polysaccharides esterified with gadolinium diethylenetriaminepentaacetic acid (GdDTPA) are described. The results of several synthetic methods are presented for esterification of dextrans and inulin with DTPA. One method results in highly conjugated products labeled with an average of 0.4 mol of GdDTPA/mol of glucopyranose unit in dextrans of up to 70,800 average molecular weight and 0.5 mol of GdDTPA/mol of fructofuranose unit in inulin. Chromatographic and potentiometric evidence supporting the absence of significant chelate cross-linking of the conjugated polysaccharides is presented. The thermodynamic stability constant, log K (Gd3+ + L4(-)----GdL-), of the complexes was 18.0 +/- 0.2 based on an independent chelate model. In vitro ester hydrolysis of the GdDTPA-dextran 70,800 (at 37 degrees C, pH = 7.4 phosphate buffer) occurs with a half-life of 21 h. The agents exhibit T1 relaxivities ranging from 1.5 to 2.3 times that of GdDTPA at 100 MHz, and decreasing in vitro relaxivity with increasing molecular weight of the dextran carrier was observed. Phantom MRI studies indicate that the T1 and T2 effects of the complexes differ from those of GdDTPA, with the polysaccharide-bound complexes exhibiting a considerably faster drop in relative signal intensity with increased concentration in T1 and T2 weighted pulse sequences.
Anatomic Plantar Plate Repair Using the Weil Metatarsal Osteotomy Approach (2011)

The purpose of this study was to analyze the early results of a new technique for anatomic plantar plate repair and advancement using a Weil metatarsal osteotomy of the second metatarsal. The authors retrospectively reviewed medical records of 13 consecutive adult patients (15 feet) who underwent this procedure by a single surgeon. The authors recorded visual analog pain scale scores preoperatively and postoperatively and patient-reported clinical outcome measurement surveys during their final follow-up visit. At an average of 22.5 months (range, 13 to 33 months) follow-up, 11 of 13 patients (85%) reported improved function whereas 10 of 13 (77%) were either satisfied or very satisfied with the outcome. Postoperative scores on the American Orthopaedic Foot and Ankle Society Lesser Metatarsophalangeal- Interphalangeal Scale averaged 85.7 on a scale of 100 (SD = 13.1, 95% CI = 79.1-91.5). Patients reported an average preoperative visual analog pain scale of 7.3 (SD = 1.6, 95% CI = 6.4-8.1) versus an average of 1.7 (SD = 1.8, 95% CI = 0.7-2.7) postoperatively. This was a significant reduction in pain rating (P < .0001, t = 8.9, df = 27). Complications included painful hardware and metatarsalgia. There were no cases of dehiscence, malunion, nonunion, or recurrent metatarsophalangeal joint subluxation. This unique surgical technique addresses metatarsal overload and the instability of the second metatarsophalangeal joint while allowing for anatomic repair of the plantar plate pathology.
P-138 - Panic disorder in the light of comorbidity: a follow-up study (2012)

Comorbid condition cause worse clinical outcome in PD The current study assessed the courses of Panic Disorder (PD) in consideration of the comorbid conditions. Patients with DSM-IV- diagnosed PD were assessed using the PD follow-up Questionnaire, Panic & Agoraphobia Scale, Hamilton Depression Rating Scale and State-Trait Anxiety Inventory. SCID (Structured Clinical Interview for DSM-IV) was used to determine comorbidity, and all participants were received to one year follow up. Comorbidity assessment showed that the threshold comorbidity decreased, although the sub threshold comorbidity increased at one year follow up. PD symptom severity was decreased but sub threshold panic symptoms continued to be present within the course of the illness. Presence of agoraphobia and duration of disease were significantly related with higher Panic & Agoraphobia Scale scores in the second assessment, and these relationships were independent from the treatment process. Even if the comorbidity and the severity of panic decrease with treatment, sub threshold panic and comorbid symptoms may still resist in panic disorder.
Identify user variants based on user behavior on social media (2015)

In social media, users are allowed to express their opinions by commenting on an item or rating an item with scores. The collection of user reviews would generate a positive or negative influence to the media audience. Some malicious users may create multiple variant accounts on the same social media so as to influence or manipulate public opinions for business or criminal purposes. To maintain good social environment, it is necessary to find those fake users. In this paper, we investigate the user variants identification problem using both user behavior and item related information. We study the characteristics of user behaviors on social media and introduce two concepts visibility and distingushibility to preliminarily quantify whether a fake user can be identified. To better understand user intention and characteristics, we profile a user with apparent and implicit features, which are extracted from three aspects: User Generated Contents (UGC), user behavior context and item information. Based on these features, we propose the user Variants Identification Problem (VIP) and an identification algorithm, which finds the top-k similar variants in a social media. We evaluate our methods against two real datasets MovieLens and Amazon and make comparison on the effectiveness against different features in identifying user variants.
Improving 2D Scatterplots Effectiveness through Sampling, Displacement, and User Perception (2006)

In this paper we present a novel, hybrid, and automatic strategy whose goal is to reduce the 2D scatter plot cluttering. The presented technique relies on a combination of nonuniform sampling and pixel displacement and it is driven by perceptual results coming from a suitable user study. The same results are used to define precise quality metrics that allow for validating our approach.
Optical Techniques for Detecting and Identifying Biological-Warfare Agents (2009)

Rapid and accurate detection and identification of biological agents is an objective of various national security programs. Detection in general is difficult owing to natural clutter and anticipated low concentrations of subject material. Typical detection architectures comprise a nonspecific trigger, a rapid identifier, and a confirming step, often in a laboratory. High-confidence identification must be made prior to taking action, though this must be traded against regrets stemming from delay. Sensing requirements are best established by positing plausible scenarios, two of which are suggested herein. Modern technologies include the use of elastic scatter and ultraviolet laser-induced fluorescence for triggering and standoff detection. Optical and nonoptical techniques are used routinely in analyzing clinical samples used to confirm infection and illness resulting from a biological attack. Today, environmental sensing serves at best as an alert to medical authorities for possible action, which would include sample collection and detailed analysis. This paper surveys the state of the art of sensing at all levels.
The FPGA implementation of the RC-DBA algorithm in the EPON (2007)

In the upstream link of EPON, numerous ONUs In the reverse link of the EPON network, numerous ONUs receive the privileges to use the optical medium from the scheduler of the LOT, but not through the competition with others. Therefore, it is very important to select a proper DBA algorithm to allocatethe frequency band to each ONU in an effectively and fair manner. In our preceding study, we proposed the RC-DBA algorithm that complements many problems in existing DBA algorithms. In this paper, we designed the MAC scheduler for the OLT, which the proposed algorithmwas applied to and implement it in the FPGA. In addition, in order to verify the operation of the scheduler, we developed the embedded Linux based testbed.
Topography imaging with a heated atomic force microscope cantilever in tapping mode (2007)

This article describes tapping mode atomic force microscopy (AFM) using a heated AFM cantilever. The electrical and thermal responses of the cantilever were investigated while the cantilever oscillated in free space or was in intermittent contact with a surface. The cantilever oscillates at its mechanical resonant frequency, 70.36 kHz, which is much faster than its thermal time constant of 300 micros, and so the cantilever operates in thermal steady state. The thermal impedance between the cantilever heater and the sample was measured through the cantilever temperature signal. Topographical imaging was performed on silicon calibration gratings of height 20 and 100 nm. The obtained topography sensitivity is as high as 200 microVnm and the resolution is as good as 0.5 nmHz(1/2), depending on the cantilever power. The cantilever heating power ranges 0-7 mW, which corresponds to a temperature range of 25-700 degrees C. The imaging was performed entirely using the cantilever thermal signal and no laser or other optics was required. As in conventional AFM, the tapping mode operation demonstrated here can suppress imaging artifacts and enable imaging of soft samples.
A fully humanized transgenic mouse model of Huntington disease (2012)

Silencing the mutant huntingtin gene (muHTT) is a direct and simple therapeutic strategy for the treatment of Huntington disease (HD) in principle. However, targeting the HD mutation presents challenges because it is an expansion of a common genetic element (a CAG tract) that is found throughout the genome. Moreover, the HTT protein is important for neuronal health throughout life, and silencing strategies that also reduce the wild-type HTT allele may not be well tolerated during the long-term treatment of HD. Several HTT silencing strategies are in development that target genetic sites in HTT that are outside of the CAG expansion, including HD mutation-linked single-nucleotide polymorphisms and the HTT promoter. Preclinical testing of these genetic therapies has required the development of a new mouse model of HD that carries these human-specific genetic targets. To generate a fully humanized mouse model of HD, we have cross-bred BACHD and YAC18 on the Hdh 2/2 background. The resulting line, Hu97/18, is the first murine model of HD that fully genetically recapitulates human HD having two human HTT genes, no mouse Hdh genes and heterozygosity of the HD mutation. We find that Hu97/18 mice display many of the behavioral changes associated with HD including motor, psychiatric and cognitive deficits, as well as canonical neuropathological abnormalities. This mouse line will be useful for gaining additional insights into the disease mechanisms of HD as well as for testing genetic therapies targeting human HTT.