gebhart/patrepeval huggingface dataset:
Efficient service recommendation system for cloud computing market (2009)

In recent years, Cloud computing is gaining much popularity as it can efficiently utilize the computing resources and hence can contribute to the issue of Green IT to save energy. So to make the Cloud services commercialized, Cloud markets are necessary and are being developed. As the increasing numbers of various Cloud services are rapidly evolving in the Cloud market, how to select the best and optimal services will be a great challenge. In this paper we present a Cloud service selection framework in the Cloud market that uses a recommender system (RS) which helps a user to select the best services from different Cloud providers (CP) that matches user requirements. The RS recommends a service based on the network QoS and Virtual Machine (VM) platform factors of difference CPs. The experimental results show that our Cloud service recommender system (CSRS) can effectively recommend a good combination of Cloud services to consumers.
Chimeric human-mouse IgG antibodies with shuffled constant region exons demonstrate that multiple domains contribute to in vivo half-life. (1998)

Structural features that determine the differing rates of immunoglobulin catabolism are of great relevance to the engineering of immunologically active reagents. Sequences in the CH2 and CH3 region of IgG have been shown to regulate the rate of clearance through their interaction with FcRn. In an attempt to probe additional structural features that regulate antibody half-life, we have investigated two families of chimeric antibodies, composed of identical murine heavy and light antidansyl variable regions joined to human kappa light-chains and wild-type or shuffled human IgG heavy-chain constant regions. These antibodies were iodinated, and their clearance was studied in severe combined immunodeficient mice hosts by whole-body radioactivity measurements. Clearances of the wild-type and recombinant antibodies were biphasic. In a panel of immunoglobulins derived from IgG2 and IgG3, as successive domains were varied from gamma2 to gamma3, beta-phase half-life gradually decreased from 337.0 h to 70.6 h. Statistical analysis suggested that the composition of each of the three domains affected half-life, and no single region of the molecule by itself determined the rate of clearance. In the second panel of immunoglobulins derived from IgG1 and IgG4, the construct with the amino terminus portion of the molecule derived from IgG4, joined within the CH2 domain to the COOH terminus portion of IgG1, had a half-life paradoxically greater than either IgG1, or IgG4 (P < 0.012). All four IgG1/IgG4 constructs demonstrated presence of the concentration catabolism phenomenon, which is a unique hallmark of immunoglobulin catabolism. The contribution of all three constant region domains to immunoglobulin half-life may be due to distant conformational effects in addition to direct binding to protective receptors, and emphasizes the importance of distant sequences on the rate of immunoglobulin catabolism. Interesting possibilities regarding mechanisms controlling immunoglobulin metabolism are raised by the hybrid gamma4/gamma1 molecule with a half-life greater than either parental immunoglobulin. Understanding the relationships between the structure of these molecules and their clearance rate will further our ability to produce immunoglobulins with improved pharmacokinetic properties.
Interactive techniques for implicit modeling (1990)

Recent research has demonstrated the usefulness of implicit surfaces for modeling geometric objects. The interactive design of such surfaces has not, however, received the same attention as has the design of parametric surfaces. Principally this is due to the difficulty of controlling the shape of implicit surfaces while displaying the changes quickly enough for use within an interactive design environment. This paper describes progress towards interactive control of implicit surfaces and introduces new techniques useful to the designer.
Passive, light intensity-independent interferometricmethod for fibre Bragggrating interrogation (1999)

The authors describe a passive technique for sensing the strain-induced wavelength shift of a fibre Bragg grating (FBG) using a Mach-Zehnder interferometer that utilises a 3 × 3 coupler. Laboratory data show that a resolution of ~10 nε/√Hz RMS is achievable with inherent insensitivity to source intensity variations.
Excitatory Actions of FMRFamide-Related Peptides (FaRPs) on the Neurogenic <i>Limulus</i> Heart (1994)

The actions of FMRFamide-related peptides (FaRPs) on the neurogenic heart of the horseshoe crab, Limulus polyphemus, were investigated. Excitatory chronotropic effects were produced by application of TNRNFLRFamide, SDRNFLRFamide, GYNRS-FLRFamide, or pQDPFLRFamide to the intact heart preparation. Effects were dose-dependent with a threshold of 10(-9) M or less. TNRNFLRFamide and SDRNFLRFamide increased the burst rate of the isolated Limulus cardiac ganglion. Synthetic FaRPs produced inotropic excitation of the heartbeat as well. GYNRSFLRFamide, TNRNFLRFamide, SDRNFLRFamide, and pQDPFLRFamide increased heart contraction strength at a threshold dose of approximately 10(-8) M. TNRNFLRFamide and SDRNFLRFamide enhanced electrically evoked contractions of the Limulus myocardium, elicited contracture in some preparations, and increased the excitability of cardiac muscle fibers. The presence of cardioactive FaRPs in the Limulus central nervous system was suggested by reverse phase HPLC of acidified methanol extracts of Limulus nervous tissue. Four peaks of FaRP-like bioactivity were detected with the Busycon radula protractor muscle bioassay. These peaks also contained FaRP-like immunoreactivity. Two of these partially purified peaks produced excitatory chronotropic effects on the intact Limulus heart preparation similar to those produced by synthetic FaRPs.
Segmenting Overseas British Holidaymakers by Personal Values (2001)

Abstract The study is in an attempt to detect overseas British holidaymaker segments based on personal values. A data collected from 305 overseas British travelers are analyzed in the study. With a hierarchical cluster analysis, two clusters of mutually exclusive group are emerged. Subsequently, a K-means cluster analysis is further deployed to divide the samples into two distinct segments. The first segment is labeled as Agenda Achievers while the second as Relationship Seekers. In the conclusion, various marketing implications are rendered; additionally, the limitations of the study and further research avenues are acknowledged.
Computer Image 1989 (1989)

Image von Computerfirmen. Themen: Gestützter und ungestützter Bekanntheitsgrad vonHerstellerfirmen aus der Computerbranche; besterComputerhersteller; Vergleich des Images der HerstellerCommodore, IBM, Nixdorf und Siemens bezüglich ihrerfinanziellen Lage, ihres Rufs, der Arbeitnehmerorientierung,der Führungsqualität, der technologischen Entwicklung, derKundenfreundlichkeit, der Hilfsbereitschaft bzw. Kooperationund der Produktqualität; Beurteilung des Umweltbewußtseins undder Sponsoring-Aktivitäten der Unternehmen; Selbsteinschätzungdes Interesses an Computern; eigene Erfahrung mit Computern undHerkunft dieser Erfahrung. Demographie: Alter; Geschlecht; Familienstand; Beruf; Berufstätigkeit;Haushaltseinkommen; Personen mit eigenem Einkommen im Haushalt;Haushaltsgröße; Haushaltszusammensetzung; Befragter istHaushaltsvorstand; Charakteristika des Haushaltsvorstands; Befragte istHausfrau; Ortsgröße; Bundesland; Schuldbildung.
New hemostatic agents in the combat setting (2009)

Hemostatic agents stop or decrease bleeding. Whereas HemCon appears to be safe, QuikClot may produce superficial burns. These new hemostatic agents have a place in the surgical armamentarium to assist in controlling internal hemorrhage from truncal and pelvic hemorrhage, especially during damage-control surgery.
211. Combination of Forced Transduction of P53 and an Agent That Blocks MDM2-p53 Interactions Produces Synergistic Cytotoxicity on Mesothelioma Defective of the INK4A/ARF Region (2016)

A majority of malignant mesothelioma specimens possesses the wild-type p53 gene with a homologous deletion in the INK4A/ARF locus which encodes the p14ARF and the p16INK4A genes. Consequently, the p53 downstream pathways are functionally inactivated since the p14 defect augments activities of MDM2 which mediates p53 degradation through the ubiquitination processes. Furthermore, a loss of p16 induces pRb phosphorylation and uninhibited cell cycle progression through up-regulated CKD activities. We then examined possible anti-tumor effects of MDM2 inhibitors, Nutlin-3a and RITA, on human mesothelioma cells in combination of adenoviruses expressing the p53 gene (Ad-p53). Nutlin-3a, inhibiting the MDM2-p53 interactions, increased p53 phosphorylation levels and suppressed viability of mesothelioma cells in a p53-dependent manner. RITA, although blocked the MDM2-p53 interactions and phosphorylated p53, inhibited viability of mesothelioma cells independently of the p53 geneotype. Transduction of mesothelioma cells with Ad-p53 induced apoptotic cell death irrespective of the genotype. Moreover p21 induced by Ad-p53 dephosphorylated pRb and subsequently inhibited cell cycle progression. A combinatory use of Ad-p53 and Nutlin-3a or RITA, produced synergistic cytotoxicity of mesothelioma irrespective of the p53 geneotype. In addition, we demonstrated that the combination produced anti-tumor effects in an orthotopic animal model, mesothelioma developed in the pleural cavity in nude mice. In contrast, heat shock protein 90 inhibitors, blocking functions of MDM4, a homologous gene product of MDM2 without ubiquitination activities, did not produce the synergistic cytotoxicity with Ad-p53. These data collectively showed that MDM2 inhibitors enhanced expression levels of endogenous and exogenously transduced p53 through increased stability of the gene produce, and consequently activated the p53-mediated apoptosis. The p53-directed therapy is thus a possible therapeutic strategy for mesothelioma with the INK4A/ARF deletion.
Antiparasitic Alkaloids from <i>Psychotria klugii</i> (2003)

Psychotria klugii yielded two new benzoquinolizidine alkaloids, klugine (1) and 7'-O-demethylisocephaeline (2), together with the previously known cephaeline (3), isocephaeline (4), and 7-O-methylipecoside (5). The structures and stereochemistry of 1 and 2 were determined by 1D and 2D NMR data and circular dichroism experiments. Cephaeline (3) demonstrated potent in vitro antileishmanial activity against Leishmania donavani (IC50 0.03 μg/mL) and was >20- and >5-fold more potent than pentamidine and amphotericin B, respectively, while klugine (1) (IC50 0.40 μg/mL) and isocephaeline (4) (IC50 0.45 μg/mL) were <13- and <15-fold less potent than 3. In addition, emetine (6) (IC50 0.03 μg/mL) was found to be as equally potent as 3, but was >12-fold more toxic than 3 against VERO cells (IC50 0.42 vs 5.3 μg/mL). Alkaloids 1 and 3 exhibited potent antimalarial activity against Plasmodium falciparum clones W2 and D6 (IC50 27.7−46.3 ng/mL). Compound 3 was cytotoxic to SK-MEL, KB, BT-549, and SK-OV-3 human cancer cells, while 1 was inactive.
Load balancing and hot spot relief for hash routing among a collection of proxy caches (2003)

Hash routing partitions the entire URL space among a collection of cooperating proxy caches. Each partition is assigned to a cache server. Duplication of cache contents is eliminated. Client requests to a cache server for non-assigned partition objects are forwarded to proper sibling caches. As a result, the load level of the cache servers can be quite unbalanced. We examine an adaptable controlled replication (ACR) of non-assigned partition objects in each cache server to reduce the load imbalance and relieve the problem of hot-spot references. Trace-driven simulations are conducted to study the effectiveness of ACR. The results show that: (1) access skew exists, and the load of the cache servers tends to be unbalanced in hash routing; (2) with a relatively small amount of ACR, say 10% of the cache size, significant improvements in load balance can be achieved; and (3) ACR provides a very effective remedy for load imbalance due to hot-spot references.
Augmentation of Spinal Arthrodesis With Autologous Bone Marrow in a Rabbit Posterolateral Spine Fusion Model (1999)

In cases for which an adequate quantity of autogenous bone graft is not available, addition of bone marrow may facilitate greater bone formation and successful fusion.
Inhibition of HSV-1 proliferation by decoy phosphodiester oligonucleotides containing ICP4 recognition sequences. (1995)

Transcriptional control in eukaryotes results from the interplay between DNA sequences in promoters, enhancers, or silencers and transcription factors. Selective control of gene expression can thus be achieved by inhibiting specific transcription factor/DNA interactions. Transcriptional activity of DNA binding transcription factors can be inhibited by competition with double-stranded oligonucleotides (decoys) that contain their specific recognition sequences. The immediate early protein ICP4 of herpes simplex virus type 1 (HSV-1) is a sequence-specific DNA binding protein that is essential for viral replication. We synthesized double-stranded hairpin phosphodiester oligonucleotides carrying ICP4 sites and demonstrated their ability to specifically titrate ICP4. Upon addition to Vero cells, ICP4 hairpin decoys significantly reduced HSV-1 titers (IC50 = 0.3 microM), whereas a control hairpin oligonucleotide had no activity. Antiviral activity of ICP4 hairpin decoys was correlated to their relative binding affinities. These results show that phosphodiester oligonucleotides can compete for binding of specific transcription factors within cells, thus providing a potential therapeutic tool to control disease-causing genes.
Internal Combustion Engine Handbook Basics, Components, Systems, and Perspectives (2004)

This is a translation of the German book Handbuch Verbrennungsmotor and considers all aspects of the internal combustion engine. The chapters include: historical review; definition and classification of reciprocating piston engines; characteristics; maps; thermodynamic fundamentals; crank gears; engine components; lubrication; friction; charge cycle; supercharging of internal combustion engines; mixture formation and related systems; ignition; combustion; combustion systems; electronics and mechanics for engine management and transmission shift control; the powertrain; sensors; actuators; cooling of internal combustion engines; exhaust emissions; operating fluids; filtration of operating fluids; calculation and simulation; combustion diagnostics; fuel consumption; noise emissions; alternative propulsion systems; and outlook.
Dual targeting of xylanase to chloroplasts and peroxisomes as a means to increase protein accumulation in plant cells (2005)

One of the limiting factors in the production of recombinant proteins in transgenic plants is the low level of protein accumulation. A strategy was investigated for a high level of protein accumulation in plant cells. A fungal xylanase encoded by XYLII of Trichoderma reesei was chosen as the model protein because xylanases have a high potential for applications in environment-related technologies. Xylanase was expressed in the cytosol or targeted either to chloroplasts or peroxisomes alone, or to both organelles simultaneously. When xylanase was targeted to both chloroplasts and peroxisomes simultaneously the amount of xylanase accumulated was 160% of that in chloroplasts alone and 240% of that in peroxisomes alone although the transcript levels were similar among these constructs. The growth stage of the transgenic plants also affected the total amount of xylanase; the highest level of accumulation occurred at the time of flowering. This study provides genetic and biochemical data demonstrating that a high level of protein accumulation in transgenic plants can be obtained by targeting a protein to both chloroplasts and peroxisomes at the same time.
Production Increase of Heavy Oils By Electromagnetic Heating (1976)

Abstract Several methods of accelerating oil flow by applying heat from the wellbore to the reservoir have been successfully field tested. However, it appears that the possibility of heating by high-frequency radiation has not been extensively investigated, either theoretically or experimentally The concepts involved are discussed and a mathematical model is developed in order to evaluate the temperature distributions and other physical effects resulting from the radiation of electromagnetic energy into an oil reservoir. Flow performance is compared to the unheated case on the basis of a steady-state temperature distribution, which is derived. The results of a pre-steady-state transient flow condition are also presented. Calculations based on the mathematical model developed indicate that further work is warranted to prove or disprove the feasibility of this method of stimulation. A brief discussion of completion and engineering problems is included. Introduction From time to time, the technical literature has made reference to heat stimulation by the radiation of electromagnetic energy from the wellbore. A Russian paper(1) touched on one aspect of the subject, and compared electromagnetic and contact heating for a shut-in well, using a spherically symmetric model. The possibilities of concurrent flow and power input were not discussed. It should be emphasized that this paper deals not with conduction or induction, but true radiation, as exemplified by the output of a short-wave radio station. In the broadest terms, electromagnetic effects are exhibited from the lowest frequencies (e.g. 60 cycle and lower) to the very highest (X-rays, gamma radiation, etc.). For the practical purpose of wellbore heating, however, the following discussion should be viewed in terms of those frequencies at which high power can be generated on a continuous basis. At the present, this includes frequencies up to about 20000 megacycles per second. Figure 1 shows schematically the mode of operation envisioned for radiation heating.
Proline Oxidase Induces Apoptosis in Tumor Cells, and Its Expression Is Frequently Absent or Reduced in Renal Carcinomas (2003)

Proline oxidase is a p53-induced gene that can mediate apoptosis in lung carcinoma cells. Here, we provide evidence implicating a role for proline oxidase in renal carcinoma. We observed absent or reduced expression of proline oxidase in 8 of 12 primary renal cell carcinomas, with respect to their normal tissue counterparts. Two renal cell carcinomas, which displayed little or no expression of proline oxidase, expressed p53s that were less capable of inducing proline oxidase than p53 isolated from normal renal tissue. One of those tumor-derived p53s contained a double transition mutation at amino acid residues 125 (Ala to Thr) and 193 (Arg to His), and the other exhibited a single transition mutation at amino acid 149 (Ser to Phe). Forced up-regulation of proline oxidase induced the formation of reactive oxygen species and mediated apoptosis in the 786-0 renal cell carcinoma cell line. A proline oxidase antisense vector repressed p53-induced up-regulation of proline oxidase, release of cytochrome c from mitochondria, and apoptosis in 786-0 renal carcinoma cells. Taken together, these findings support a role for proline oxidase as a downstream effector in p53-mediated apoptosis. We hypothesize that its altered expression can contribute to the development of renal carcinomas. The presence of proline oxidase in mitochondria, a primary organelle that regulates apoptosis, places this molecule in a subcellular localization that can directly influence the apoptotic pathway and thus tumorigenesis.
Handbook of Detergents, Part F (2008)

This sixth part of the multi-volume Handbook of Detergents focuses on the production of surfactants, builders and other key components of detergent formulations, including the various multi-dimensional aspects and implications on detergent formulations and applications domestically, institutionally, in industry and agriculture, with all the environ
Angiotensin II Blockade and Aortic-Root Dilation in Marfan's Syndrome (2008)

In a small cohort study, the use of ARB therapy in patients with Marfan's syndrome significantly slowed the rate of progressive aortic-root dilation. These findings require confirmation in a randomized trial.
MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers (2008)

Hippocampal volume change over time, measured with MRI, has huge potential as a marker for Alzheimer's disease. The objectives of this study were: (i) to test if constant and accelerated hippocampal loss can be detected in Alzheimer's disease, mild cognitive impairment and normal ageing over short periods, e.g. 6-12 months, with MRI in the large multicentre setting of the Alzheimer's Disease Neuroimaging Initiative (ADNI); (ii) to determine the extent to which the polymorphism of the apolipoprotein E (ApoE) gene modulates hippocampal change; and (iii) to determine if rates of hippocampal loss correlate with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, such as the beta-amyloid (Abeta(1-42)) and tau proteins (tau). The MRI multicentre study included 112 cognitive normal elderly individuals, 226 mild cognitive impairment and 96 Alzheimer's disease patients who all had at least three successive MRI scans, involving 47 different imaging centres. The mild cognitive impairment and Alzheimer's disease groups showed hippocampal volume loss over 6 months and accelerated loss over 1 year. Moreover, increased rates of hippocampal loss were associated with presence of the ApoE allele epsilon4 gene in Alzheimer's disease and lower CSF Abeta(1-42) in mild cognitive impairment, irrespective of ApoE genotype, whereas relations with tau were only trends. The power to measure hippocampal change was improved by exploiting correlations statistically between successive MRI observations. The demonstration of considerable hippocampal loss in mild cognitive impairment and Alzheimer's disease patients over only 6 months and accelerated loss over 12 months illustrates the power of MRI to track morphological brain changes over time in a large multisite setting. Furthermore, the relations between faster hippocampal loss in the presence of ApoE allele epsilon4 and decreased CSF Abeta(1-42) supports the concept that increased hippocampal loss is an indicator of Alzheimer's disease pathology and a potential marker for the efficacy of therapeutic interventions in Alzheimer's disease.
Plasma proteome profiling reveals biomarker patterns associated with prognosis and therapy selection in glioblastoma multiforme patients (2010)

Candidate plasma proteins signatures associated with GBM was outlined, that could be used for GBM classification and for pre-operatively stratifying patients according to the beneficial effect of the adopted immunotherapy.
An intelligent discussion-bot for answering student queries in threaded discussions (2006)

This paper describes a discussion-bot that provides answers to students' discussion board questions in an unobtrusive and human-like way. Using information retrieval and natural language processing techniques, the discussion-bot identifies the questioner's interest, mines suitable answers from an annotated corpus of 1236 archived threaded discussions and 279 course documents and chooses an appropriate response. A novel modeling approach was designed for the analysis of archived threaded discussions to facilitate answer extraction. We compare a self-out and an all-in evaluation of the mined answers. The results show that the discussion-bot can begin to meet students' learning requests. We discuss directions that might be taken to increase the effectiveness of the question matching and answer extraction algorithms. The research takes place in the context of an undergraduate computer science course.