gebhart/patrepeval huggingface dataset:
Suppression of Ripening and Softening of `Galia' Melons by 1-Methylcyclopropene Applied at Preripe or Ripe Stages of Development (2005)

`Galia' ( Cucumis melo var. reticulatus L. Naud. `Galia') melons exhibit relatively short postharvest longevity, limited in large part by the rapid softening of this high quality melon. The present study was performed to characterize the physiological responses of `Galia' fruit harvested at green (preripe) and yellow (advanced ripening) stages and treated with 1-methylcyclopropene (1-MCP) before storage at 20 °C. Treatment with 1.5 μL·L -1 1-MCP before storage delayed the climacteric peaks of respiration and ethylene production of green fruit by 11 and 6 d, respectively, and also significantly suppressed respiration and ethylene production maxima. Softening of both green and yellow fruit was significantly delayed by 1-MCP. During the first 5 d at 20 °C, the firmness of green control fruit declined 66% while 1-MCP-treated fruit declined 46%. By day 11, firmness of control and 1-MCP-treated green fruit had declined about 90% and 75%, respectively. The firmness of control yellow fruit stored at 20 °C declined 70% within 5 d while 1-MCP-treated fruit declined 30%. The 1-MCP-induced firmness retention was accompanied by significant suppression of electrolyte leakage of mesocarp tissue, providing evidence that membrane dysfunction might contribute to softening of `Galia' melons. The mesocarp of fruit harvested green and treated with 1-MCP eventually ripened to acceptable quality; however, under the treatment conditions (1.5 μL·L -1 1-MCP, 24 h) used in this study, irreversible suppression of surface color development was noted. The disparity in ripening recovery between mesocarp versus epidermal tissue was considerably less evident for fruit harvested and treated with 1-MCP at an advanced stage of development. The commercial use of 1-MCP with `Galia'-type melons should prove of immense benefit in long-term storage and/or export situations, and allow for retention of quality and handling tolerance for fruit harvested at more advanced stages of ripening.
Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo. (1996)

The role of prostaglandin E2 (PGE2) in the development of inflammatory symptoms and cytokine production was evaluated in vivo using a neutralizing anti-PGE2 monoclonal antibody 2B5. In carrageenan-induced paw inflammation, pretreatment of rats with 2B5 substantially prevented the development of tissue edema and hyperalgesia in affected paws. The antibody was shown to bind the majority of PGE2 produced at the inflammatory site. In adjuvant-induced arthritis, the therapeutic administration of 2B5 to arthritic rats substantially reversed edema in affected paws. Anti-PGE2 treatment also reduced paw levels of IL-6 RNA and serum IL-6 protein without modifying tumor necrosis factor RNA levels in the same tissue. In each model, the antiinflammatory efficacy of 2B5 was indistinguishable from that of the nonsteroidal antiinflammatory drug indomethacin, which blocked the production of all PGs. These results indicate that PGE2 plays a major role in tissue edema, hyperalgesia, and IL-6 production at sites of inflammation, and they suggest that selective pharmacologic modulation of PGE2 synthesis or activity may provide a useful means of mitigating the symptoms of inflammatory disease.
All-silica single-mode optical fiber with photonic crystal cladding: errata (1997)

See original paper at: \n&amp;lt;A HREF="http://eprints.soton.ac.uk/78031/"&amp;gt;http://eprints.soton.ac.uk/78031/&amp;lt;/A&amp;gt;
Uptake of 67Cu by Ceruloplasmin In Vitro (1975)

Solutions of human ceruloplasmin, in Tris buffer at pH values between 6 and 7.5, readily took up carrier-free 67Cu2+, but only when the substrate, rho-phenylenediamine, was added.
Near-Optimal Worst-Case Throughput Routing for Two-Dimensional Mesh Networks (2005)

Minimizing latency and maximizing throughput are important goals in the design of routing algorithms for interconnection networks. Ideally, we would like a routing algorithm to (a) route packets using the minimal number of hops to reduce latency and preserve communication locality, (b) deliver good worst-case and average-case throughput and (c) enable low-complexity (and hence, low latency) router implementation. In this paper, we focus on routing algorithms for an important class of interconnection networks: two dimensional (2D) mesh networks. Existing routing algorithms for mesh networks fail to satisfy one or more of design goals mentioned above. Variously, the routing algorithms suffer from poor worst case throughput (ROMM by Nesson, and Johnsson (1995), DOR by Sullivan and Bashkow, 1977), poor latency due to increased packet hops (VALIANT by Valiant and Brebner (1981)) or increased latency due to hardware complexity (minimal-adaptive by Duato, (1993), Upadhyay, Varavithya and Mohapatra, (1997)). The major contribution of this paper is the design of an oblivious routing algorithm-O1TURN-with provable near-optimal worst-case throughput, good average-case through-put, low design complexity and minimal number of network hops for 2D-mesh networks, thus satisfying all the stated design goals.
An Efficient Synthesis of a Furan-Side Furocoumarin Thymidine Monoadduct (1997)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTAn Efficient Synthesis of a Furan-Side Furocoumarin Thymidine MonoadductWilliam R. Kobertz and John M. EssigmannView Author Information Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 Cite this: J. Org. Chem. 1997, 62, 8, 2630–2632Publication Date (Web):April 18, 1997Publication History Received8 October 1996Published online18 April 1997Published inissue 1 April 1997https://pubs.acs.org/doi/10.1021/jo9619084https://doi.org/10.1021/jo9619084brief-reportACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views202Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Adducts,Genetics,Nucleic acids,Reaction products,Stereochemistry Get e-Alerts
Query optimization (1996)

article Free AccessQuery optimization Author: Yannis E. Ioannidis Computer Sciences Department, University of Wisconsin, Madison Computer Sciences Department, University of Wisconsin, MadisonView Profile Authors Info & Claims ACM Computing SurveysVolume 28Issue 1pp 121–123https://doi.org/10.1145/234313.234367Published:01 March 1996Publication History 146citation4,759DownloadsMetricsTotal Citations146Total Downloads4,759Last 12 Months1,230Last 6 weeks125 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Highly active and selective palladium catalyst for hydroesterification of styrene and vinyl acetate promoted by polymeric sulfonic acids (2005)

Highly efficient, selective and recyclable palladium catalyst systems for hydroesterification of styrene and vinyl acetate were realized by using 1,2-bis(di-tert-butylphosphinomethyl)benzene as ligand and polymeric sulfonic acids of limited SO(3)H loadings as promoter.
Treatment of distal aneurysms of the cerebellar arteries by intraaneurysmal injection of glue. (1999)

Distal aneurysms of the cerebellar arteries are associated with a poor prognosis, as surgery or embolization with GDCs is very difficult. We report our experience with a new therapeutic method involving intraaneurysmal injection of glue. Three aneurysms were catheterized with a flow-guided microcatheter, and glue was slowly injected into the aneurysms. In two cases, treatment resulted in total occlusion of the aneurysm with preservation of the parent artery. In one case, the aim was to occlude both the aneurysm and parent artery.
Substance P and Calcitonin Gene-Related Peptide: Effects on Mast Cells and in Human Skin (1987)

Mast cells are found in close association with blood vessels, and histamine is known to be a potent vasodilator in humans. It is now clear that mast cells form neuroeffector junctions and that one of the types of nerve involved is the peptide-containing primary afferent neurone (C fibre). Nerve stimulation produces vasodilation which is blocked by antihistamines or by depletion of mast cell histamine with compound 48/80. Nerve stimulation also releases histamine and degranulates mast cells. Substance P and other neuropeptides release histamine from isolated rat and human skin mast cells. The actions of substance P and calcitonin gene-related peptide in human skin are compatible with a role for these two peptides in neurogenic inflammation. The inflammatory effects of substance P in human skin are inhibited by antihistamines. The possible role of the mast cell in neurogenic inflammation is discussed.
Rigid body simulation with contact and constraints (2009)

We present techniques for constructing an interactive rigid body simulation system, and describe our implementation such a system. We use a constraint-based simulation approach, incorporating a time stepping method which handles multiple contacts with friction in a general way. We describe a method for constraint stabilization for simulations with contact. The method is based on the post-stabilization methods of Ascher and Chin, but is formulated as a linear complementarity problem, allowing us to solve for the stabilization step when there are redundant inequality (contact) constraints. As an application of our simulation software, we present a method for human character animation where motion capture data is used to drive a rigid body simulation. This allows physical constraints and forces acting on the character to be taken into account.
On the cusp of change for Learning in the Oil &amp; Gas Industry (2018)

Learning Systems for geophysicists have been traditionally founded upon a strong basis of mathematics and physics and supported with real-life and work experiences that mature their ability to positively contribute to the Oil & Gas Industry. Although other data types have brought important contributions to the Industry, seismic data has played the single, most influential role in Exploration & Production, and the rapid development of seismic data acquisition, processing and interpretation methods has formed the basis for the bulk of training that geophysicists have received. This type of technical knowledge transfer lends itself to proven historical learning methods and geophysical curriculums that were initiated at universities, and which were subsequently built upon by Industry employers. This Learning System focused upon the geophysical discipline, and although effective, was slow, expensive and limited in its maturation of future O&G Industry leadership. The geophysicist of today is facing increased pressure to contribute to industry success quickly, and to demonstrate a broader set of skills across an increasingly diverse portfolio. The traditional Learning Systems of the past are not well-suited to this new environment which is characterized by cross-disciplinary collaboration and integration, and by a growing data richness and complexity! Learning Systems will have to change to meet increasing industry demands, and to meet today’s emerging professional’s style. This change in Learning Systems will include changes in learning topics and materials, changes in delivery systems, and a rebalancing of responsibility across learning providers. Such a system will focus upon supporting the geophysicist of the future who will serve as an equal collaborator on a multi-disciplinary team immersed in real-time data streams. Presentation Date: Tuesday, October 16, 2018 Start Time: 1:50:00 PM Location: 204C (Anaheim Convention Center) Presentation Type: Oral
Synthesis of 5′-Methylene-Phosphonate Furanonucleoside Prodrugs: Application to <scp>D</scp>-2′-Deoxy-2′-α-fluoro-2′-β-<i>C</i>-methyl Nucleosides (2012)

A new and facile synthetic pathway to metabolically stable 5'-methylene-bis(pivaloyloxymethyl)(POM)phosphonate furanonucleoside prodrugs is reported. The key step involves a Horner-Wadsworth-Emmons reaction of a tetra(pivaloyloxymethyl) bisphosphonate salt with appropriately protected 5'-aldehydic nucleosides. This efficient approach was applied for the synthesis HCV related 2'-deoxy-2'-α-fluoro-2'-β-C-methyl nucleosides.
Pattern recognition, spatial predictability, and subtraction of multiple events (1999)

The suppression of multiple events is a crucial task when processing seismic data because they can obscure, or sometimes be mistaken for, genuine reflections. This task has been with us for a long time. The ambiguities caused by multiple reflections are perhaps more acutely felt today, with the growing need for reliable seismic attributes at the target level. From the processing side, although many techniques have been described in the literature, only a few have reached the industrial stage.
Cloning and primary structure of <i>Staphylococcus aureus</i> DNA topoisomerase IV: a primary target of fluoroquinolones (1994)

A 4.6 kb Staphylococcus aureus DNA fragment containing DNA gyrase-like genes (grlA and grlB) was cloned and sequenced. The proteins GrlA and GrlB exhibit more than 30% identity with E. coli DNA topoisomerase IV subunits and with the gyrase subunits from S. aureus and Escherichia coli. The combined E. coli cell extracts of GrlA and GrlB overproducing strains catalysed ATP-dependent relaxation and decatenation specific to DNA topoisomerase IV. The temperature-sensitive phenotype of Salmonella typhimurium parC and parE mutants was complemented by the S. aureus grlA and grlB genes, when the two genes were co-expressed. These results show that GrlA and GrlB are the subunits of S. aureus DNA topoisomerase IV. The GyrA subunit of DNA gyrase has been previously defined as a primary target of quinolones based on genetic and biochemical experiments essentially carried out in E. coli. Single-point mutations occurring in the 'quinolone resistance-determining region' (QRDR) of GyrA were found in bacteria exhibiting quinolone resistance, the most common mutation being a substitution of Ser-83 on the E. coli GyrA sequence. We analysed eight S. aureus fluoroquinolone-resistant clinical isolates and observed that mutations in the QRDR of GyrA are not present in the low-quinolone-resistant isolates. In contrast, Ser-80 of GrlA, which corresponds to Ser-83 of E. coli GyrA, is substituted to Phe or Tyr in both high- and low-quinolone-resistant isolates. We propose that DNA topoisomerase IV is a primary target of fluoroquinolones in S. aureus.
High-Affinity Recognition of Lanthanide(III) Chelate Complexes by a Reprogrammed Human Lipocalin 2 (2009)

Human lipocalin 2 (Lcn2), also known as neutrophil gelatinase-associated lipocalin (NGAL), which naturally scavenges bacterial ferric siderophores, has been engineered to specifically bind rare-earth and related metal ions as chelate complexes with [(R)-2-amino-3-(4-aminophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diaminepentaacetic acid (p-NH(2)-Bn-CHX-A''-DTPA). To this end, 12 amino acid residues in the ligand pocket of Lcn2, which is formed by four loops at the open end of an eight-stranded beta-barrel, were subjected to targeted random mutagenesis, and from the resulting library, variants with binding activity for the Me x DTPA group were selected using the method of bacterial phage display. One promising candidate was further developed in several cycles of in vitro affinity maturation using partial random mutagenesis and selection (via phage display and/or Escherichia coli colony screening) under conditions of increasing stringency. As result, an Lcn2 variant was obtained that binds Y x DTPA with a dissociation constant as low as 400 pM. The Lcn2 variant specifically recognizes the artificial ligand, as exemplified in (competitive) ELISA and real-time surface plasmon resonance analyses. DTPA-complexed Y(3+), Tb(3+), Gd(3+), and Lu(3+) are most tightly bound, comprising metal ions whose isotopes are in common use for radiotherapy and imaging. All of the Lcn2 variants are stably folded and can be functionally produced in high yield in E. coli. X-ray crystallographic analyses show that the new ligand is well-accommodated in the central cavity of the engineered lipocalin, whose fold is largely preserved, but that the mode of binding differs from the one seen with the natural ligand Fe x enterobactin. This structural study reveals analogies but also differences with respect to previously described antibody-metal chelate complexes. Notably, the functionalized side chain of DTPA protrudes from the ligand pocket of the lipocalin in such a way that its conjugates (with other haptens, for example) are recognized too. With their small sizes and robust fold based on a single polypeptide chain, the engineered Lcn2 variants provide novel modules and/or fusion partners for radionuclide-chelate capturing strategies that bear promise for medical diagnostics and therapy.
Mechanical effects of copper through-vias in a 3D die-stacked module (2003)

Mechanical effects of copper through-vias formed in silicon dies in a three dimensional module, in which four bare-dies with copper through-vias are vertically stacked and electrically connected through the copper-vias and metal bumps, were numerically and experimentally studied. To examine the mechanical effects caused by the existence of the copper through-vias in a rigid silicon-chip, a series of stress analyses, related simple mechanical tests, and reliability tests were carried out. All these results show that the copper through-via has unique effects on the stress distribution caused by thermal mismatch and on the interconnection reliability in the 3D die-stacked module. In particular, it was found that the developed micro copper through-via is reliable because the stress distribution due to thermal load is close to the hydrostatic pressure condition, and enhances chip-to-chip interconnection reliability because the copper-via restrains the plastic deformation of a gold bump during temperature cycling.
Nicotine absorption and the subjective and physiologic effects of nicotine toothpicks (1991)

This study investigated a new tobacco-free smoking substitute intended to provide not only the nicotine but also, to some extent, the manipulative component of the smoking act. Nicotine uptake and cardiovascular and subjective effects of nicotine-containing toothpicks (4 mg) were compared with those of nicotine chewing gum (4 mg). After the two products were chewed for 5 minutes, the nicotine uptake from the toothpick was twofold that of the gum. However, comparing the total nicotine deliveries of both products, they are quite similar. The cardiovascular parameters showed a clear nicotine effect, but they did not differentiate between the two products. Among the subjective parameters there were only minor differentiations. However, the potential advantages of the toothpicks: (1) dental care and (2) a possible substitute for the manipulative component of the smoking act, remain to be verified in further experiments.
Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis (2002)

Previous studies have revealed that autoantibodies, complement components, and Fc receptors each participate in the pathogenesis of erosive arthritis in K/BxN mice. However, it is not known which cellular populations are responsive to these inflammatory signals. We find that two strains of mice deficient in mast cells, W/Wv and Sl/Sld, were resistant to development of joint inflammation and that susceptibility was restored in the W/Wv strain by mast cell engraftment. Thus, mast cells may function as a cellular link between autoantibodies, soluble mediators, and other effector populations in inflammatory arthritis.
Analysis of Fc (IgG) receptors on human peripheral blood leukocytes by dual fluorescence flow microfluorometry. II. Quantitation of receptors on cells that express the OKM1, OKT3, OKT4, and OKT8 antigens. (1983)

Human peripheral blood mononuclear cells were analyzed for the expression of Fc(IgG) receptors (FcR) by a quantitative dual fluorescence flow microfluorometric (FMF) technique. Mononuclear cells from all donors tested were distributed into three distinct subsets on the basis of FcR expression: cells expressing high, intermediate, or background levels of FcR. To characterize these subsets, cells were doubly labeled for FcR and with OKM1, OKT3, OKT4, or OKT8 hybridoma antibodies by using nonoverlapping red and green fluorophores. Each cell was then analyzed for the presence of both labels with a dual laser flow cytometer. Cells that did not express FcR were heterogeneous for OKT3, OKT4, and OKT8, did not express OKM1, and were primarily T cells on the basis of rosette formation with sheep erythrocytes (E+ cells). Most of the cells that expressed intermediate levels of FcR (an average of 1.3 x 10(4) FcR/cell) also expressed high levels of OKM1 but did not bind OKT3, OKT4, or OKT8 hybridoma antibodies. These cells were characterized as monocytes because they were removed by passage over Sephadex G-10 columns and because they were larger than the other cells as judged by light scatter. The majority of cells with the highest FcR density (an average of 4.5 x 10(4) FcR/cell) formed rosettes with E and were, by definition, T gamma cells. These cells expressed negligible levels of OKT4 and intermediate levels of OKM1, levels that clearly distinquished them from monocytes. The T gamma cells were heterogeneous in the expression of both OKT3 and OKT8, with approximately 20% being positive for OKT3 and OKT8. The level of OKT3 expression for the OKT3 and OKT8. The level of OKT3 expression for the OKT3+ T gamma cells was about the same as for as for OKT3+ T nongamma cells. In contrast, the OKT8 T nongamma cells expressed lower levels of OKT8 than did the OKT8+ T nongamma cells. By compaing our results with those obtained by other invesigators, we tentatively assigned functions to the subsets of cells that we describe here.