gebhart/patrepeval huggingface dataset:
Forced convective interlayer cooling in vertically integrated packages (2008)

The heat removal capability of area-interconnect-compatible interlayer cooling in vertically integrated, high-performance chip stacks was characterized with de-ionized water as coolant. Correlation-based predictions and computational fluid dynamic modeling of cross-flow heat-removal structures show that the coolant temperature increase due to sensible heat absorption limits the cooling performance at hydraulic diameters les 200 mum. An experimental investigation with uniform and double-side heat flux at Reynolds numbers les 1000 and heat transfer areas of 1 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> was carried out to identify the most efficient interlayer heat-removal structure. Parallel plate, microchannel, pin fin, and their combinations with pins using in-line and staggered configurations with round and drop-like shapes at pitches ranging from 50 to 200 mum and fluid structure heights of 100 to 200 mum were tested. A hydrodynamic flow regime transition responsible for a local junction temperature minimum was observed for pin fin inline structures. The experimental data was extrapolated to predict maximal heat flux in chip stacks with a 4-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> heat transfer area. The performance of interlayer cooling strongly depends on this parameter, and drops from >200 W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at 1 cm2 and >50 mum interconnect pitch to <100 W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at 4 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Trajectory tracking nonlinear model predictive control for autonomous surface craft (2013)

This paper presents a solution to the problem of trajectory-tracking control for autonomous surface craft (ASC) in the presence of ocean currents. The proposed solution is rooted in nonlinear model predictive control (NMPC) techniques and addresses explicitly state and input constraints. Whereas state saturation constraints are added to the underlying optimization cost functional as penalties, input saturation constraints are made intrinsic to the nonlinear model used in the optimization problem, thus reducing the computational burden of the resulting NMPC algorithm. Simulation and experimental results show that the NMPC strategy adopted yields good performance in the presence of constant currents and validate the real-time implementation of the proposed techniques.
Galectin-1 Suppresses Autoimmune Retinal Disease by Promoting Concomitant Th2- and T Regulatory-Mediated Anti-Inflammatory Responses (2006)

Intraocular inflammatory diseases are a common cause of severe visual impairment and blindness. In this study, we investigated the immunoregulatory role of galectin-1 (Gal-1), an endogenous lectin found at sites of T cell activation and immune privilege, in experimental autoimmune uveitis (EAU), a Th1-mediated model of retinal disease. Treatment with rGal-1 either early or late during the course of interphotoreceptor retinoid-binding protein-induced EAU was sufficient to suppress ocular pathology, inhibit leukocyte infiltration, and counteract pathogenic Th1 cells. Administration of rGal-1 at the early or late phases of EAU ameliorated disease by skewing the uveitogenic response toward nonpathogenic Th2 or T regulatory-mediated anti-inflammatory responses. Consistently, adoptive transfer of CD4(+) regulatory T cells obtained from rGal-1-treated mice prevented the development of active EAU in syngeneic recipients. In addition, increased levels of apoptosis were detected in lymph nodes from mice treated with rGal-1 during the efferent phase of the disease. Our results underscore the ability of Gal-1 to counteract Th1-mediated responses through different, but potentially overlapping anti-inflammatory mechanisms and suggest a possible therapeutic use of this protein for the treatment of human uveitic diseases of autoimmune etiology.
Transfer of Ultrathin Silicon Layers to Polycrystalline SiC Substrates for the Growth of 3C‐SiC Epitaxial Films (1999)

A novel approach for the production of large area 3C‐SiC substrates is described. Ultrathin (<20 nm) Si seed layers were transferred to high purity polycrystalline 3C‐SiC substrates through a unique wafer bonding process. The ultrathin Si seed layer was subsequently carbonized and used as the nucleation layer for high temperature (>1500°C) growth of epitaxial 3C‐SiC. The use of more optimal growth temperatures, not limited by the melting point of Si, led to 3C‐SiC films of high crystalline quality. Double crystal X‐ray diffraction measurements of the 3C‐SiC(200) reflection gave peak widths of 660 arcsec. © 1999 The Electrochemical Society. All rights reserved.
Harvesting Energy From Magnetic Fields to Power Condition Monitoring Sensors (2013)

Condition monitoring is playing an increasingly important role within electrical power networks, where its use can help to reduce maintenance costs, improve supply reliability, and permit increased utilization of equipment capacity by providing a measure of actual operating conditions as an alternative to relying on more stringent “worst case scenario” assumptions. In this context, energy harvesting may have a role to play in that it offers the possibility of realizing autonomous, self-powering sensors that communicate their data wirelessly. In the vicinity of electrical transmission and distribution equipment, alternating magnetic fields at the power frequency offer a potential source of energy that does not require hard-wiring or batteries. There are many potentially useful locations for sensors where the level of magnetic flux density may be sufficient to provide enough power for a low-power wireless sensor node. This paper describes a free-standing inductive harvester for use in positions where there is an ambient magnetic field due to conductors that are remote and/or inaccessible. Using data from surveys of magnetic flux density levels at two substations, optimum core and coil designs for the harvester are obtained through theoretical analyses and experiments. A demonstrator is then constructed in which a wireless sensor becomes self-powering when immersed in a 50-Hz magnetic field. Laboratory results show that this system can deliver a useful average power of 300 μW when placed in a magnetic flux density of 18 μ <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Trms</i> .
Squeezing the Optical Near-Field Zone by Plasmon Coupling of Metallic Nanoparticles (1999)

We report on the experimental observation of near-field optical effects close to Au nanoparticles using a photon scanning tunneling microscope (PSTM). Constant height operation of the PSTM allowed an unprecedented direct comparison with theoretical computations of the distribution of the optical near-field intensity. An unexpected squeezing of the optical near field due to plasmon coupling was observed above a chain of Au nanoparticles.
A Fresh Perspective on Total Cost of Ownership Models for Flash Storage in Datacenters (2016)

Recently, adoption of Flash based devices has become increasingly common in all forms of computing devices. Flash devices have started to become more economically viable for large storage installations like datacenters, where metrics like Total Cost of Ownership (TCO) are of paramount importance. Flash devices suffer from write amplification (WA), which, if unaccounted, can substantially increase the TCO of a storage system. In this paper, we develop a TCO model for Flash storage devices, and then plug a Write Amplification (WA) model of NVMe SSDs we build based on empirical data into this TCO model. Our new WA model accounts for workload characteristics like write rate and percentage of sequential writes. Furthermore, using both the TCO and WA models as the optimization criterion, we design new Flash resource management schemes (minTCO) to guide datacenter managers to make workload allocation decisions under the consideration of TCO for SSDs. Experimental results show that minTCO can reduce the TCO and keep relatively high throughput and space utilization of the entire datacenter storage.
Visual Teach and Repeat using appearance-based lidar (2012)

Visual Teach and Repeat (VT&R) has proven to be an effective method to allow a vehicle to autonomously repeat any previously driven route without the need for a global positioning system. One of the major challenges for a method that relies on visual input to recognize previously visited places is lighting change, as this can make the appearance of a scene look drastically different. For this reason, passive sensors, such as cameras, are not ideal for outdoor environments with inconsistent/inadequate light. However, camera-based systems have been very successful for localization and mapping in outdoor, unstructured terrain, which can be largely attributed to the use of sparse, appearance-based computer vision techniques. Thus, in an effort to achieve lighting invariance and to continue to exploit the heritage of the appearance-based vision techniques traditionally used with cameras, this paper presents the first VT&R system that uses appearance-based techniques with laser scanners for motion estimation. The system has been field tested in a planetary analogue environment for an entire diurnal cycle, covering more than 11km with an autonomy rate of 99.7% of the distance traveled.
Ricin Detection by Biological Signal Amplification in a Well-in-a-Well Device (2006)

This paper presents a ricin detection method based on ricin's inhibitory effects on protein synthesis. Biological synthesis (expression) of a protein includes the steps of gene transcription (DNA --> RNA) and protein translation (RNA --> proteins); these reactions can be coupled into a one-step operation and carried out in a cell-free medium. Ricin is known to inhibit protein synthesis by interacting with 28S ribosome RNA; the inhibitory effect is exploited as the sensing mechanism in this work. For each copy of DNA, thousands of copies of proteins can be produced. As a result, the inhibitory effects of ricin are amplified, leading to a significantly enhanced detection signal (the difference between the positive control and samples). An array of protein expression units is developed to accommodate positive/negative controls and multiple samples. The array device contains a solution without any reagent captured on a solid surface, offering flexibility without comprising the activities of biomolecules. The miniaturized well-in-a-well design possesses a mechanism to supply nutrients continuously and remove byproducts, leading to higher protein expression yields and thus larger detection signals (lower detection limit) when ricin is present. We demonstrate the production of green fluorescent protein and luciferase in the device. A calibration curve has been obtained between the luciferase expression yield and the ricin concentration, showing a detection limit of 0.01 nM (0.3 ng/mL) ricin. The nested-well device is also used for measuring the toxicity level of ricin after physical or chemical treatment.
ON THE SOLUTION OF INDEFINITE QUADRATIC PROBLEMS USING AN INTERIOR-POINT ALGORITHM (1992)

Inithis paper, we discuss computational aspeets of an interior­ point algorithm (1) for indefinite quadratic programming problems with b lems with an ellipsoid constraint. In addition, we present a. sufficient condition' for a local minimizer to be global, and we use this resUlt to generate test problems with a. kno,wn global solution. The proposed algorithm has been implemented on an IBM 3090 computer and tested on a variety of den$e test problems, including problems with a known global optimizer.
Making Sense of Moments (2014)

It may seem incongruous to marry Soren Kirkegaard to Barbra Streisand, but I ask you to suspend your skepticism for a moment. The controversy around Streisand’s adaptation of the Isaac Bashevis Singer short story notwithstanding,3 the original story, the Streisand lyric, and the Kirkegaard insight all provide structure for this look back at my presence in the distinctive professional world of practice we call philosophy of education.
Summary cache (1998)

The sharing of caches among Web proxies is an important technique to reduce Web traffic and alleviate network bottlenecks. Nevertheless it is not widely deployed due to the overhead of existing protocols. In this paper we propose a new protocol called "Summary Cache"; each proxy keeps a summary of the URLs of cached documents of each participating proxy and checks these summaries for potential hits before sending any queries. Two factors contribute to the low overhead: the summaries are updated only periodically, and the summary representations are economical --- as low as 8 bits per entry. Using trace-driven simulations and a prototype implementation, we show that compared to the existing Internet Cache Protocol (ICP), Summary Cache reduces the number of inter-cache messages by a factor of 25 to 60, reduces the bandwidth consumption by over 50%, and eliminates between 30% to 95% of the CPU overhead, while at the same time maintaining almost the same hit ratio as ICP. Hence Summary Cache enables cache sharing among a large number of proxies.
Testing assumptions for endophenotype studies in ADHD: Reliability and validity of tasks in a general population sample (2005)

The data support the usefulness of the go/no-go and fast tasks for genetic studies, which require reliable and valid indices of individual differences. The overall pattern of associations between teacher ratings of ADHD symptoms and task variables is consistent with effects of event rate and incentives on performance, as predicted by the model of activation and arousal regulation. The lack of a clear pattern of findings with parent ratings of ADHD symptoms warrants further study.
Ordered Mesoporous Materials from Metal Nanoparticle–Block Copolymer Self-Assembly (2008)

The synthesis of ordered mesoporous metal composites and ordered mesoporous metals is a challenge because metals have high surface energies that favor low surface areas. We present results from the self-assembly of block copolymers with ligand-stabilized platinum nanoparticles, leading to lamellar CCM-Pt-4 and inverse hexagonal (CCM-Pt-6) hybrid mesostructures with high nanoparticle loadings. Pyrolysis of the CCM-Pt-6 hybrid produces an ordered mesoporous platinum-carbon nanocomposite with open and large pores (>/=10 nanometers). Removal of the carbon leads to ordered porous platinum mesostructures. The platinum-carbon nanocomposite has very high electrical conductivity (400 siemens per centimeter) for an ordered mesoporous material fabricated from block copolymer self-assembly.
How Does Residual Water Affect the Solid-state Degradation of Drugs in the Amorphous State? (1996)

It is widely recognized in the pharmaceutical field that exposure of solid drugs (small molecules or proteins) to high relative humidity and the resulting association of water vapor with the solid generally accelerate the rate of chemical degradation.1 Although there are true solid-state reactions that take place only in the crystalline state or to a much lesser extent in the liquid or solution state than in the crystal,2,3 most instabilities observed for drugs occur in solution much more readily than in the solid state; when they do occur over practical time scales in the solid state, it is very likely that the reaction is taking place in the more disordered amorphous regions of the solid.4 Indeed, it has been shown in a number of cases that under otherwise identical conditions reactivity of a particular substance in the amorphous state is greater than that in the crystalline state.5-8 Generally, for reactions occurring in the amorphous solid state, the rate of reactivity increases with increasing water content, and this can be attributed to the ability of the amorphous solid to absorb water vapor into its bulk structure, forming an amorphous solution.9,10 In a few cases it has been reported that a certain amount of water must be present to ensure chemical stability, e.g., lipid peroxidation rates decrease with the addition of small amounts of water;11,12 however, a destabilizing effect of absorbed water is more generally the case for the major types of drug degradations, e.g., hydrolysis, oxidation, or deamidation. An examination of the literature indicates that discussions concerning solid-state reactivity in the amorphous state have followed along two lines. In some work correlations appear to exist between the rate of reactivity and the glass transition temperature, Tg, strongly supporting the role of water as a plasticizer in facilitating chemical reactivity by increasing molecular mobility.13,14 In other studies, a lack of correlation with Tg and reactivity well below Tg has been shown to occur, and there also appears to be a better correlation of reactivity with water activity, aw, defined as: aw ) p/po (1)
Immunotherapy of prostate cancer in the Dunning rat model: use of cytokine gene modified tumor vaccines. (1994)

Adenocarcinoma of the prostate is the most common cancer in men. The majority of cancers are discovered once they have already metastasized, and there is no effective therapy for prostatic cancer at this stage. The use of cytokine-secreting tumor cell preparations as therapeutic vaccines for the treatment of advanced prostate cancer was investigated in the Dunning rat R3327-MatLyLu prostatic tumor model. IL-2 secreting, irradiated, tumor cell preparations were capable of curing animals with s.c. established tumors, and induced immunological memory that protected animals from subsequent tumor challenge. Immunotherapy was less effective when tumors were induced orthotopically, but nevertheless led to improved outcome, significantly delaying, and occasionally preventing, recurrence of tumors after resection of the cancerous prostate. Granulocyte-macrophage colony stimulating factor secreting tumor cell preparations were less effective, and interferon-gamma secreting cells had only a marginal effect. Induction of a potent immune response in tumor bearing animals against the nonimmunogenic MatLyLu tumor supports the view that active immunotherapy warrants further investigation as a potential therapeutic approach to prostate cancer.
Setting Job-Shop Due-Dates with Service-Level Constraints (1985)

The job-shop due-date assignment problem arises when a manager needs to ‘promise’ a delivery date to a customer. Previous methods yield due-dates which are either optimistic (unlikely to be achieved) or conservative (the promise will be met, but too easily, because the date given was very pessimistic). This paper investigates the due-date assignment problem with a customer ‘service-level’ constraint, the percentage of time that promised delivery dates are honoured. We formulate a rule to attain this service level, yet maintain as short a due-date lead time as possible. Unlike previous attempts, this due-date rule considers not only the job content and instantaneous shop congestion information, but also implicitly incorporates information on how the jobs will be scheduled (or ‘loaded’) once they are in the shop. We simulate a single-machine shop for various measures of performance under several dispatching priorities, comparing our due-date rule with one reported to yield satisfactory performance. Our rule meets all requirements and is found to be superior for most measures of performance.
β1 Integrin Regulates Fibroblast Viability during Collagen Matrix Contraction through a Phosphatidylinositol 3-Kinase/Akt/Protein Kinase B Signaling Pathway (2002)

Integrins regulate cell viability through their interaction with the extracellular matrix. Integrins can sense mechanical forces arising from the matrix and convert these stimuli to chemical signals capable of modulating intracellular signal transduction. The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway is a major regulator of cell survival. It is not known, however, whether integrins, acting as mechanoreceptors, regulate cell survival via the PI3K/Akt pathway. Here, we show that in response to a matrix-derived mechanical stimulus, beta1 integrin regulated cell viability by regulating Akt activity in a PI3K-dependent fashion. To accomplish this, we employed fibroblasts cultured in collagen gels. During contraction of collagen matrices, fibroblasts underwent apoptosis. We demonstrate that ligation of beta1 integrin with anti-beta1 integrin antibodies protected fibroblasts from apoptosis. The nature of the survival signal activated by beta1 integrin engagement with antibody was mediated by PI3K acting through Akt/protein kinase B. We show that Akt phosphorylation decreased during collagen contraction and that this decrease correlated precisely with the onset of fibroblast apoptosis. Fibroblasts transfected with constitutively active PI3K displayed increased Akt phosphorylation and were protected from anoikis and collagen gel contraction-induced apoptosis. Our data identify a novel role for beta1 integrin in regulating fibroblast viability through a PI3K/Akt/protein kinase B signaling pathway in response to a matrix-derived mechanical stimulus.
Supramolecular Assembly Promotes the Electrocatalytic Reduction of Carbon Dioxide by Re(I) Bipyridine Catalysts at a Lower Overpotential (2014)

The addition of methyl acetamidomethyl groups at the 4,4'-positions of a 2,2'-bipyridyl ligand is found to enhance the rate of a bimolecular reduction mechanism of CO2 by Re(I) fac-tricarbonyl chloride complexes. Electrochemical studies, spectroelectrochemical measurements, and molecular dynamics simulations indicate that these methyl acetamidomethyl groups promote the formation of a hydrogen-bonded dimer. This supramolecular complex catalyzes the reductive disproportionation of CO2 to CO and CO3(2-) at a lower overpotential (ca. 250 mV) than the corresponding single-site 2 e(-) reduction of CO2 to CO and H2O catalyzed by the corresponding model complex with a 4,4'-dimethyl-2,2'-bipyridyl ligand. These findings demonstrate that noncovalent self-assembly can modulate the catalytic properties of metal complexes by favoring alternate catalytic pathways.
Disruption of PDGF Receptor Trafficking by Mutation of Its PI-3 Linase Binding Sites (1994)

Human platelet-derived growth factor receptors (PDGFRs) expressed in human Hep G2 cells internalized and concentrated in a juxtanuclear region near the Golgi network within 10 minutes after the cells were treated with PDGF. A PDGFR mutant (F5) that lacks high-affinity binding sites for the Src homology 2 domain-containing proteins phosphatidylinositol-3 kinase (PI-3 kinase), Ras guanosine triphosphatase activating protein, phospholipase C-gamma, and a phosphotyrosine phosphatase (Syp) remained at the cell periphery. Restoration of the PI-3 kinase binding sites on F5 completely restored the ability of the receptor to concentrate intracellularly. A PDGFR mutant lacking only PI-3 kinase binding sites failed to concentrate intracellularly. Thus, PI-3 kinase binding sites appear both necessary and sufficient for the normal endocytic trafficking of the activated PDGFR.