gebhart/patrepeval huggingface dataset:
MUC1 as a target antigen for cancer immunotherapy (2005)

The cancer-associated antigen MUC1 is overexpressed and modified by tumor cells in over half of all cancer cases. Despite various complexities associated with this antigen, it is well worth pursuing as a vaccine for the immunotherapy of cancer. In this review, the authors describe the discovery of MUC1 and its association with cancer, recent observations showing that the immunology of MUC1 is complicated, animal data showing that it can be a target for immune-mediated tumor rejection, and finally, preliminary clinical results to show that vaccine-based immunotherapy with MUC1 does have an impact on the therapy of cancer.
Catechol O-methyltransferase. 5. Structure-activity relations for inhibition by flavonoids (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatechol O-methyltransferase. 5. Structure-activity relations for inhibition by flavonoidsRonald T. Borchardt and Joan A. HuberCite this: J. Med. Chem. 1975, 18, 1, 120–122Publication Date (Print):January 1, 1975Publication History Published online1 May 2002Published inissue 1 January 1975https://pubs.acs.org/doi/10.1021/jm00235a030https://doi.org/10.1021/jm00235a030research-articleACS PublicationsRequest reuse permissionsArticle Views592Altmetric-Citations114LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A micromachined thermally compensated thin film Lamb wave resonator for frequency control and sensing applications (2009)

Micromachined thin film plate acoustic wave resonators (FPARs) utilizing the lowest order symmetric Lamb wave (S0) propagating in highly textured 2 µm thick aluminium nitride (AlN) membranes have been successfully demonstrated (Yantchev and Katardjiev 2007 IEEE Trans. Ultrason. Ferroelectr. Freq. Control 54 87–95). The proposed devices have a SAW-based design and exhibit Q factors of up to 3000 at a frequency around 900 MHz as well as design flexibility with respect to the required motional resistance. However, a notable drawback of the proposed devices is the non-zero temperature coefficient of frequency (TCF) which lies in the range −20 ppm K−1 to −25 ppm K−1. Thus, despite the promising features demonstrated, further device optimization is required. In this work temperature compensation of thin AlN film Lamb wave resonators is studied and experimentally demonstrated. Temperature compensation while retaining at the same time the device electromechanical coupling is experimentally demonstrated. The zero TCF Lamb wave resonators are fabricated onto composite AlN/SiO2 membranes. Q factors of around 1400 have been measured at a frequency of around 755 MHz. Finally, the impact of technological issues on the device performance is discussed in view of improving the device performance.
Rural Women Empowerment through Entrepreneurship Development (2011)

Empowerment of women has emerged as an important issue these days as a Sinequo-non of progress for the national economy and is of paramount importance topolitical thinkers, social scientists and reformers. Women constitute 90 percent oftotal marginal workers of the country. Rural women engaged in agricultureconstitutes 78 percent of all women in regular work and the contribution of womenand their role in the family as well as in the economic development and socialtransformation are pivotal. Women are engaged in various farming activities,livestock management, post harvest and allied activities. The need of the hour is toempower them technically to cope with the changing times and productivity usingtheir free time and existing skills for setting and sustaining enterprises. Microenterprises could be an effective instrument of social and economic developmentand rural women posses abundant resources to take up enterprises. The economicempowerment of women leads to development of family and community”.
Outcomes after Transplantation of Cord Blood or Bone Marrow from Unrelated Donors in Adults with Leukemia (2004)

HLA-mismatched cord blood should be considered an acceptable source of hematopoietic stem-cell grafts for adults in the absence of an HLA-matched adult donor.
Miniature robots for space and military missions (1999)

Miniature robots enable low-cost planetary surface exploration missions as well as new military missions in urban terrain where small robots provide critical assistance to human operations. These space and military missions have many similar technological challenges. This article describes the technologies under development, the applications where these technologies are relevant to both space and military missions, and the status of the most recent technology demonstrations in terrestrial scenarios.
Channel Aware Scheduling in MU-DCF WLANs (2007)

Multiple input-multiple output (MIMO) stands for a wide set of multiple antenna technologies, which significantly increase the capacity of wireless networks, without additional bandwidth or transmission power. They are widely recognized as methods that can meet the ever growing network capacity requirements. With a MIMO physical layer (PHY), the transmission channel gets a layered structure, which gives another degree of freedom when scheduling transmissions. Support from higher layers with a cross-layer approach that provides efficient management of the channels spatial layers, can significantly increase the networks performance on both link and system level. A multiple access control (MAC) protocol with the support for multi-user (MU)-MIMO transmissions in ad-hoc WLANs - multi-user-DCF (MU-DCF), has been previously presented. In this paper we introduce channel aware scheduling for opportunistic channel usage and exploiting MU diversity. We evaluate the benefits of the channel aware scheduling with respect to the produced overhead for signaling, channel estimation and channel quality Information (CQI) feedback.
Spectroscopic Ellipsometry (2007)

Ellipsometry is a powerful tool used for the characterization of thin films and multi-layer semiconductor structures. This book deals with fundamental principles and applications of spectroscopic ellipsometry (SE). Beginning with an overview of SE technologies the text moves on to focus on the data analysis of results obtained from SE, Fundamental data analyses, principles and physical backgrounds and the various materials used in different fields from LSI industry to biotechnology are described. The final chapter describes the latest developments of real-time monitoring and process control which have attracted significant attention in various scientific and industrial fields.
SNAP: A General Purpose Network Analysis and Graph Mining Library (2016)

Large networks are becoming a widely used abstraction for studying complex systems in a broad set of disciplines, ranging from social network analysis to molecular biology and neuroscience. Despite an increasing need to analyze and manipulate large networks, only a limited number of tools are available for this task. Here, we describe Stanford Network Analysis Platform (SNAP), a general-purpose, high-performance system that provides easy to use, high-level operations for analysis and manipulation of large networks. We present SNAP functionality, describe its implementational details, and give performance benchmarks. SNAP has been developed for single big-memory machines and it balances the trade-off between maximum performance, compact in-memory graph representation, and the ability to handle dynamic graphs where nodes and edges are being added or removed over time. SNAP can process massive networks with hundreds of millions of nodes and billions of edges. SNAP offers over 140 different graph algorithms that can efficiently manipulate large graphs, calculate structural properties, generate regular and random graphs, and handle attributes and meta-data on nodes and edges. Besides being able to handle large graphs, an additional strength of SNAP is that networks and their attributes are fully dynamic, they can be modified during the computation at low cost. SNAP is provided as an open source library in C++ as well as a module in Python. We also describe the Stanford Large Network Dataset, a set of social and information real-world networks and datasets, which we make publicly available. The collection is a complementary resource to our SNAP software and is widely used for development and benchmarking of graph analytics algorithms.
Gapless THz Comb Spectroscopy (2014)

We demonstrated combination of gapless terahertz (THz) comb with asynchronous-optical-sampling THz time-domain spectroscopy (ASOPS-THz-TDS), namely gapless THz comb spectroscopy. The mode-resolved spectrum of THz comb was observed by measuring the temporal waveform of the THz pulse train with ASOPS-THz-TDS and calculating Fourier transform of it. Furthermore, the gapless THz comb was realized by interpolating frequency gaps between the comb modes with sweeping of a laser mode-locked frequency. The demonstration of low-pressure gas spectroscopy with gapless THz comb spectroscopy clearly indicated that the spectral resolution was decreased down to 2.5-MHz linewidth of the comb mode and the spectral accuracy was enhanced to 10‒7 within the spectral range of 1 THz. The proposed method will be a powerful tool to simultaneously achieve high resolution, high accuracy, and broad spectral coverage in THz spectroscopy.
The Effect of an Aromatase Inhibitor, 4-Hydroxy-4-Androstene- 3,17-Dione, On Estrogen-Dependent Processes in Reproduction and Breast Cancer<sup>1</sup><sup>1</sup> (1977)

4-Hydroxy-f-androstene-3,17-dione (4-OH-A) when tested at various concentrations was found to inhibit markedly the conversion of 4-andorstene-3,17-dione to estrogens inhuman placental and rat ovarian microsomes. To obtain evidence that estrogen biosynthesis could also be reduced in vivo with 4-OH-A, rats were treated sc at a dose level of 50 mg/kg body weight. After 3 h the ovarian veins were cannulated and blood collected. Estradiol concentrations in the plasma were reduced by 80% compared to control values during the proestrous surge and on Day 4 of pregnancy. 4-OH-A was also found to be effective in controlling estrogen-dependent reproductive and neoplastic processes. In rats treated from Day 2-7 of pregnancy, implantation of fertilized ova was completely prevented in some rats, while in others either implantation was delayed or the development of implants was retarded. 4-OH-A treatment of rats having estrogen-dependent breast tumors induced by 7,12-dimethylbenz(a)anthracene caused 80% of the tumors to regress significantly in 4 weeks of treatment; 42% of these regressed completely.
Polymorphs of a Cocrystal with Achiral and Chiral Structures Prepared by Pseudoseeding:  Tryptamine/Hydrocinnamic Acid (2001)

Helical-type of chiral cocrystal of tryptamine and hydrocinnamic acid was prepared by crystallization in the presence of different chiral crystals having similar crystal structures, despite spontaneous crystallization itself giving only achiral crystal.
Endocardial and Epicardial Ablation Guided by Nonsurgical Transthoracic Epicardial Mapping to Treat Recurrent Ventricular Tachycardia (1998)

Epicardial mapping does not enhance the effectiveness of endocardial pulses of RF. Epicardial applications of RF energy can safely and effectively treat patients with VT and Chagas' disease.
Microscopical investigations on the epicuticle of mammalian keratin fibres (2001)

The existence of a thin chemically resistant layer, the epicuticle, close to the surfaces of all undamaged mammalian keratin fibres has been known since 1916. The identification of such a specific structure within the fibre cuticle has remained elusive. Now, through transmission electron microscope investigations of stained transverse sections of hairs from various animal species, the epicuticle has been tentatively identified as a sharply defined and continuous layer approximately 13 nm thick covering the entire outwardly facing intracellular surface of every cuticle cell. The staining behaviour of the epicuticle leads one to suppose that it is rich in cystine and that thioester-bound lipids might be present within its bulk. With the atomic force microscope it was established that the undamaged outer surface of all mammalian keratin fibres, even including those from the monotremes, were longitudinally striated. The lateral spacing of the striations was always in the range 0.29-0.39 microm. Striations only occurred on the freely exposed outer surfaces of the original undamaged fibres; evidently arising by some, as yet undefined, interaction in the follicle with the cuticle of the inner root sheath. By stripping off fatty acids known to be covalently attached to the fibre's outer surface, the striations were shown to reflect a corresponding irregularity of the epicuticle's surface.
Microrheological Modeling of Flow-Induced Crystallization (2001)

The problem of flow-induced crystallization (FIC) of polymer melts is addressed via a microrheological approach. In particular, the Doi−Edwards model with the so-called independent alignment approximation (DE−IAA) is used to calculate the flow-induced change of free energy. Subsequently, the crystallization induction time, i.e., the nucleation characteristic time, is calculated in isothermal steady shear and uniaxial elongational flows. Asymptotic, analytical expressions for the induction time are also derived in the limit of low and high Deborah number (the product of the deformation rate and the polymer relaxation time). The DE−IAA model is found to give more realistic predictions than those of simpler, dumbbell-like models already proposed in the literature. When compared to existing FIC experimental data in shear flow, good quantitative agreement is found with the polymer relaxation time as the only adjustable parameter of the model.
Selectins and IL-6 during the Clinical Course of Idiopathic Thrombocytopenic Purpura (1999)

'Stress thrombocytes', i.e. large and presumably hyperfunctioning platelets, is a well-known characteristic of patients with idiopathic thrombocytopenic purpura (ITP). Therefore, despite what may be severe thrombocytopenia these patients generally do not suffer from severe life-threatening hemorrhage. The plasma level of soluble P-selectin (sP-selectin) is a valuable marker reflecting platelet activation. Available data suggest that interleukin-6 (IL-6) may contribute to the regulation of megakaryocytopoiesis and platelet activity. The purpose of this study is to investigate the status and kinetics of IL-6 and selectins, which are involved in the platelet function, production, and immunologic functions, during the clinical course of ITP, that may be helpful for understanding the biology of the disease. Twenty-two ITP patients were studied prospectively in the course of their disease. Sixteen, 8 and 6 patients were available after platelet recovery, relapse and splenectomy, respectively. Fifteen healthy persons served as a control group. Higher levels of both sP-selectin and IL-6 were observed in all clinical stages of disease compared to the control group. However, more prominent elevations were present during active stages of ITP, i.e. pretreatment (p < 0.001 vs. control group for both sP-selectin and IL-6) and relapse periods (p < 0.001 vs. control group for both sP-selectin and IL-6). Pretreatment soluble L-selectin and soluble E-selectin levels were not different from the controls. Both sP-selectin (r = -0.32, p = 0.019) and IL-6 (r = -0. 41, p = 0.002) levels inversely correlated with platelet count during disease course. There was a positive correlation between the sL-selectin level and leukocyte count (r = 0.60, p < 0.001). These results suggest that residual platelets are activated in ITP, which offers a relatively benign clinical course compared to other thrombocytopenias. High IL-6 concentration during thrombocytopenia may be involved in compensatory megakaryocytopoiesis and augmented 'residual platelet' functions in ITP.
Chromosomal latency and expression at map unit 96 of a wild-type plus adeno-associated virus (AAV)/Neo vector and identification of p81, a new AAV transcriptional promoter. (2000)

These data demonstrate that ins96-0.9Neo will be useful for studying wild-type AAV integration and suggest that such wild-type plus recombinant AAV vectors may be useful for human gene therapy. The advantages of using such wild-type plus AAV vectors over defective AAV vectors include the ease in production of recombinant virus and the ability for site-specific integration into chromosome 19. This study also uncovered a previously unknown AAV promoter, p81. This finding suggests that the as yet uncharacterized ORF (nt 3922-4388) located just downstream of this promoter is likely an expressed gene. Furthermore, these data support our earlier findings that the AAV virion can package >900 bases more than can the wild-type.
Insulin and intestinal epithelial cell proliferation (1993)

The effects of modification of the levels of endogenous plasma insulin on intestinal epithelial cell proliferation were investigated in rats maintained by total parenteral nutrition (TPN) using either a TPN diet that was high in glucose, or a low glucose (hypocaloric) TPN diet and in orally fed rats (normal and sham operated). The rats were put on their respective treatments for 7 days and were then injected with vincristine sulphate to arrest cells as they entered metaphase. Intestinal tissue was fixed for the determination of crypt cell production rate (CCPR) and blood plasma was taken for hormone radioimmunoassay. Sham operation had no effect on either plasma hormone levels or on CCPR. The standard TPN diet was associated with significantly reduced levels of gastrin, peptide YY and enteroglucagon. Gastrin and PYY were further reduced by the hypocaloric diet. However, plasma insulin was much increased in the TPN but not in the hypocaloric group. Small intestinal CCPR was reduced in the TPN groups, but no difference was observed between the standard and the low calorie TPN diets. The lack of difference in CCPR between the two TPN diets despite the massive elevation of plasma insulin strongly suggests that insulin does not have a substantial role in the control of gastrointestinal epithelial cell renewal.
Efficient TEM <sub>00</sub> operation of Nd:YVO <sub>4</sub> laser end pumped by fibre-coupled diode laser (1997)

The authors have demonstrated efficient TEM00 operation of the Nd:YVO4 rod laser, one-end-pumped by a one-fibre-coupled diode laser. A 11.6 W linearly polarised laser output with an optical efficiency of 54% in TEM00 mode has been achieved.
Polymethacrylate–Silica Hybrid Nanoporous Materials: A Bridge Between Inorganic and Polymeric Molecular Sieves (2000)

Mesoporosity combined with organic polymer functionality and hydrophobicity could give rise to promising new materials with applications in host–guest chemistry and biosensor devices. The synthesis of polymer–silica hybrid mesoporous materials with pore sizes of 3–6 nm is described, in which materials with large specific surface areas (∼800 m2 g–1) and pore volumes (∼0.7 cm3 g–1) as well as relatively narrow pore size distributions are produced by a sol-gel reaction in the presence of a non-surfactant template or pore-forming agent, which is subsequently removed by solvent extraction.
Packaging the Micro-Machine (2000)

ABSTRACT Micro-machine technology has been demonstrated in research and development facilities for at least 25 years. In some forms it has been in production for almost 20 years, specifically semiconductor pressure sensors. But new techniques have enabled the formation of surface structures, and more recently true micro-machine engineering has been enabled by new iterative etching techniques. Applications for these technologies range from sensors, telecommunications, micro-switch, and for the future true micro-machines. The technology is now considered to be production ready, and there are a significant number of companies developing products targeted at a mass market. There are however to date very few products in production. It is clearly early in the commercialization of this technology, but one area, which has been repeatedly identified as a problem to successful commercialization of the technology, is appropriate device packaging. This is no longer the case, today there are more packaging options available than ever before. This year alone in the US 900 patents will be filed in the arena of packaging technology. The problem can be more accurately defined as a lack of knowledge on how to apply the current packaging technologies to the micro-machine product. The key issue facing the packaging of bare die is the problem of dice separation. The current standard die separation method is wafer saw where the silicon wafer is cut by a diamond impregnated blade. This blade and wafer is flooded with high purity water while the blade spins at 45K RPM. For the standard silicon wafer this poses no problem. The surface is essentially sealed from the effects of the water and silicon dust. The micro machine element, when exposed to the water blast and the debris, tends to break or become clogged. Efforts to protect these surfaces with photo resist or other coatings have met with limited success and are expensive.
Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a proximal region containing a CCAAT motif which interacts with CTF/NF-I. (1991)

The 78-kDa glucose-regulated protein (GRP78) is a major endoplasmic reticulum (ER) protein that can form stable associations with a variety of proteins retained in the ER because of underglycosylation or other conformational changes. In this study, we provide evidence at the transcriptional level that a conformationally abnormal protein, an altered herpes simplex virus type 1 envelope protein that is retained in the ER of a mammalian cell line, transactivates the grp78 promoter. In contrast, the normal viral envelope glycoprotein does not elevate grp78 promoter activity. Using a series of 5' deletions, linker-scanning, and internal deletion mutations spanning a 100-bp region from -179 to -80, we correlate the cis-acting regulatory elements mediating the activation of grp78 by malfolded proteins, glycosylation block, and the calcium ionophore A23187. We show that they all act through the same control elements, suggesting that they share a common signal. We report here that the highly conserved grp element, while important for basal level and induced grp78 expression, is functionally redundant. The single most important element, by linker-scanning analysis, is a 10-bp region that contains a CCAAT motif. It alone is not sufficient for promoter activity, but a 40-bp region (-129 to -90) that contains this motif is essential for mediating basal level and stress inducibility of the grp78 promoter. We show that the transcription factor CTF/NF-I is able to transactivate the grp78 promoter through interaction with this CCAAT motif.