gebhart/patrepeval huggingface dataset:
Macrophage expression of interleukin-10 is a prognostic factor in nonsmall cell lung cancer (2007)

Interleukin (IL)-10 is expressed in many solid tumours and plays an ambiguous role in controlling cancer growth and metastasis. In order to determine whether IL-10 is involved in tumour progression and prognosis in nonsmall cell lung cancer (NSCLC), IL-10 expression in tumour cells and tumour-associated macrophages (TAMs) and its associations, if any, with clinicopathological features were investigated. Paraffin-embedded sections of surgical specimens obtained from 50 patients who had undergone surgery for NSCLC were immunostained with an antibody directed against IL-10. TAMs and tumour cells positive for IL-10 were subsequently quantified. IL-10-positive TAM percentage was higher in patients with stage II, III and IV NSCLC, and in those with lymph node metastases compared with patients with stage I NSCLC. High IL-10 expression by TAMs was a significant independent predictor of advanced tumour stage, and thus was associated with worse overall survival. Conversely, IL-10 expression by tumour cells did not differ between stages II, III and IV and stage I NSCLC. In conclusion, interleukin-10 expression by tumour-associated macrophages, but not by tumour cells, may play a role in the progression and prognosis of nonsmall cell lung cancer. These results may be useful in the development of novel approaches for anticancer treatments.
Original approach for the localisation of objects in images (1994)

An original approach is presented for the localisation of objects in an image which approach is neuronal and has two steps. In the first step, a rough localisation is performed by presenting each pixel with its neighbourhood to a neural net which is able to indicate whether this pixel and its neighbourhood are the image of the search object. This first filter does not discriminate for position. From its result, areas which might contain an image of the object can be selected. In the second step, these areas are presented to another neural net which can determine the exact position of the object in each area. This algorithm is applied to the problem of localising faces in images.
Mass Spectrometric Analysis of Colloid Thruster Ion Emission from Selected Propellants (2005)

Retarding potential, time-of-flight (TOF), and quadrupole mass spectrometric methods are applied to study the charged species emitted from a colloid thruster operated in a cone-jet mode at high-specific-impulse operating conditions. Measurements are conducted for two propellants, a 28.4 wt% NaI/formamide electrolyte solution and the ionic liquid 1-ethyl-3-methylimidazolium tetrafluoroborate ([EMIM][BF4]). When operated at a volume flow rate of 2‐6 × × 10 −14 m 3 /s and a positive polarity, the electrolyte solution yields an average specific charge, q/m ,o f ∼11,000 C/kg with an ion/droplet current ratio of 9 to 1. Fully angularly integrated TOF measurements determine an average mass-to-charge ratio of 253 atomic mass units. The axial quadrupole mass spectrometric measurement identifies solvated sodium ions, Na + (HCONH2)n (n =1 ,..., 10), with a distribution peaked at n =4 .Stopping potential and retarding potential measurements suggest that most charged particles are produced with energies ∼200 V below the capillary bias potential. The inability to operate this propellant in a pure ion emission mode makes the thruster inefficient when operated in the ion-evaporation, high-specific-impulse conditions. The ionic liquid, [EMIM][BF4], is operated in a pure ion emission mode for both positive and negative polarity, yielding mean specific charges exceeding 250,000 C/kg. X([EMIM][BF4])n (n =0 , 1, 2) ions, where X = EMIM + or BF − ,a re identified. Contrary to the electrolyte solution, the energy analysis of the field-evaporated ions reveals that the ions are produced at the capillary potential with a narrower energy width of 50 V. For an acceleration voltage of 1500 V, a specific impulse of ∼4000 s at an efficiency exceeding 90% is recorded.
ESTIMATES OF RED MARROW DOSE BY SACRAL SCINTIGRAPHY IN NHL PATIENTS WITH DIFFUSE BONE MARROW DISEASE (1994)

s: Fifth Conference on Radioimmunodetection and Radioimmunotherapy of Cancer: Poster Session: PDF Only
Regeneration of insertionally inactivated streptococcal DNA fragments after excision of transposon Tn916 in Escherichia coli: strategy for targeting and cloning of genes from gram-positive bacteria (1984)

The conjugative transposon Tn916 (15 kilobases), originally identified in Streptococcus faecalis DS16, has been cloned as an intact element on the pBR322-derived vector pGL101 in Escherichia coli. The EcoRI F' (EcoRI F::Tn916) fragment of pAM211 (pAD1::Tn916) was cloned into the single EcoRI site of pGL101 to form the chimera, pAM120, by selecting for the expression of Tn916-encoded tetracycline resistance (Tcr). Interestingly, in the absence of continued selection for Tcr, Tn916 excised from pAM120 at high frequency. This excision event resulted in a plasmid species consisting of the pGL101 vector and a 2.7-kilobase restriction fragment comigrating with the EcoRI F fragment of pAD1 during agarose gel electrophoresis. Filter blot hybridization experiments showed the 2.7-kilobase fragment generated as a result of Tn916 excision to be homologous with the EcoRI F fragment of pAD1. Analogous results were obtained with another chimera, pAM170, generated by ligating the EcoRI D' (EcoRI D::Tn916) fragment of pAM210 (pAD1::Tn916) to EcoRI-digested pGL101. Comparison of the AluI and RsaI cleavage patterns of the EcoRI F fragment isolated after Tn916 excision with those from an EcoRI F fragment derived from pAD1 failed to detect any difference in the two fragments: data in support of a precise Tn916 excision event in E. coli. Subcloning experiments showed that an intact transposon was required for Tn916 excision and located the Tcr determinant near the single HindIII site on Tn916. Although excision occurred with high frequency in E. coli, Tn916 insertion into the E. coli chromosome was a much rarer event. Tcr transformants were not obtained when pAM120 DNA was used to transform a polA1 strain, E. coli C2368.
Models for Dynamic Load Balancing in a Heterogeneous Multiple Processor System (1979)

Queueing models for a simple heterogeneous multiple processor system are presented, analyzed, and compared. Each model is distinguished by a job routing strategy which is designed to reduce the average job turnaround time by balancing the total load among the processors. In each case an arriving job is routed by a job dispatcher to one of m parallel processors. The job routing strategies are divided into two classes: deterministic and nondeterministic. The nondeterministic policies are described by state independent branching probabilities. For the deterministic policies, the next processor is chosen to minimize or maximize the expected value of a performance related criterion function.
Lymphocytes are detrimental during the early innate immune response against <i>Listeria monocytogenes </i> (2006)

Mice deficient in lymphocytes are more resistant than normal mice to Listeria monocytogenes infection during the early innate immune response. This paradox remains unresolved: lymphocytes are required for sterilizing immunity, but their presence during the early stage of the infection is not an asset and may even be detrimental. We found that lymphocyte-deficient mice, which showed limited apoptosis in infected organs, were resistant during the first four days of infection but became susceptible when engrafted with lymphocytes. Engraftment with lymphocytes from type I interferon receptor-deficient (IFN-alphabetaR(-/-)) mice, which had reduced apoptosis, did not confer increased susceptibility to infection, even when the phagocytes were IFN-alphabetaR(+/+). The attenuation of innate immunity was due, in part, to the production of the antiinflammatory cytokine interleukin 10 by phagocytic cells after the apoptotic phase of the infection. Thus, immunodeficient mice were more resistant relative to normal mice because the latter went through a stage of lymphocyte apoptosis that was detrimental to the innate immune response. This is an example of a bacterial pathogen creating a cascade of events that leads to a permissive infective niche early during infection.
An enhanced LPC vocoder with no voiced/Unvoiced switch (1984)

A modified LPC system (LPC plus) which requires no voiced/unvoiced switch at the synthesizer is presented in this paper. The excitation functions of the synthesizer filter are modeled to be the sum of the conventional pulse and noise sources. The mixture ratio is estimated from the LPC residual error signal, and this parameter controls the amplitudes of the pulse and noise sources. Since the V/UV switch is eliminated, this system produces robust speech in highly noisy environments, while a conventional LPC system produces degraded speech due to voicing errors. In addition, this technique has been applied to the speech of two simultaneous speakers and produces synthesized speech which is more natural and intelligible than that produced by conventional LPC.
A new approach to the synthesis of benzofuro[3,2‐<i>b</i>]quinolines, benzothieno[3,2‐<i>b</i>]quinolines and indolo[3,2‐<i>b</i>]quinolines (2000)

Abstract Treatment of 2‐hydroxy‐, 2‐mercapto‐, and 2‐ethoxycarbonylamino‐benzonitriles 12 with 2‐fluoro‐ or 2‐nitrophenacylbromides 13 under alkaline conditions provided the corresponding benzofuran, benzothiophene, and indole intermediates 10 , respectivelly. Nucleophilic cyclization of these compounds led to the corresponding tetracyclic quinolinones 7a, 7b , and 3. Denitrocyclization reaction of compounds 10 (R = NO 2 ) was found especially useful. Compounds 7a, 7b , and 3 were converted to their chloro derivatives 14a‐c , which were reduced with hydrogen and a catalyst to the corresponding compounds 8a, 8b , and 2. The presented pathway represents a new method of preparation of quindoline 2 and its O and S analogs 8. Chloro derivatives 14 are reactive enough to provide the corresponding methoxy derivatives 15 and dimethylamino derivatives 16. Methylation of compounds 7a and 7b with iodomethane providing mixtures of major N ‐methyl derivatives 17 and minor O ‐methyl derivatives 15 were also studied.
Detecting audio events for semantic video search (2009)

This paper describes our work on audio event detection, one of our tasks in the European project VIDIVIDEO. Preliminary experiments with a small corpus of sound effects have shown the potential of this type of corpus for training purposes. This paper describes our experiments with SVM classifiers, and different features, using a 290-hour corpus of sound effects, which allowed us to build detectors for almost 50 semantic concepts. Although the performance of these detectors on the development set is quite good (achieving an average F-measure of 0.87), preliminary experiments on documentaries and films showed that the task is much harder in real-life videos, which so often include overlapping audio events. Index Terms: event detection, audio segmentation
Methods for Combinatorial Organic Synthesis: The Use of Fast 13C NMR Analysis for Gel Phase Reaction Monitoring (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMethods for Combinatorial Organic Synthesis: The Use of Fast 13C NMR Analysis for Gel Phase Reaction MonitoringGary C. Look, Christopher P. Holmes, Jason P. Chinn, and Mark A. GallopCite this: J. Org. Chem. 1994, 59, 25, 7588–7590Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/jo00104a010https://doi.org/10.1021/jo00104a010research-articleACS PublicationsRequest reuse permissionsArticle Views550Altmetric-Citations142LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effects of fedotozine on gastric emptying and upper gastrointestinal symptoms in diabetic gastroparesis (2000)

Fedotozine has no effect on gastric emptying in patients with diabetic gastroparesis.
Epitaxially grown sputtered LaAlO3 films (1990)

We have grown crystalline thin films of LaAlO3 using off-axis rf sputtering from a single stoichiometric target. The films grow epitaxially on SrTiO3 and LaAlO3 (100) substrates as well as on YBa2Cu3O7 thin films. We report on the growth conditions used to make these films, the properties of the films, and the properties of bilayer and trilayer structures containing both LaAlO3 and YBa2Cu3O7 films. Transmission electron microscopy cross-sectional and x-ray diffraction analyses indicate that all the constituent films in the multilayers grow epitaxially and that the interfaces between the films are sharply defined. Preliminary transport measurements on these multilayers show that LaAlO3 can be used for dielectric layers in a variety of high-temperature superconductor electronic circuits.
Glucosinolates: The Phytochemicals of Nutraceutical Importance (2012)

Glucosinolates (thioglucoside-N-hydroxysulphates) constitute a homogeneous class of naturally occurring thiosaccharidic compounds mainly found in the botanical order Brassicales. They can be hydrolyzed by myrosinase to produce D-glucose and various other degradation products like isothiocyanates (ITCs)-depending on the aglycon part. The exact function of glucosinolates (GLSs) in the plant is unclear, however their potent odour and taste suggests a role in herbivore and microbial defense. They are known for their fungicidal, bacteriocidal, nematocidal and allelopathic properties and have recently attracted intense research interest because of their cancer chemo-protective attributes. Iso-thiocyanates, one of the hydrolyzed products, show best anti-carcinogenic activity.
AtLTP1 luciferase expression during carrot somatic embryogenesis (1997)

The carrot (Daucus carota L.) EP2 gene encodes a Lipid Transfer Protein (LTP) which is expressed during protoderm formation in developing embryos. To develop a vital reporter system for gene expression during somatic embryo development a 1.1 kB fragment of the Arabidopsis thaliana LTP1 promoter was fused to the firefly luciferase (LUC) coding sequence. The AtLTP1 luciferase expression pattern in transformed carrot suspension cultures was identical to the expression pattern of the endogenous carrot EP2 gene. Cell tracking experiments revealed that all somatic embryos were derived from AtLTP1 luciferase expressing cell clusters. However, not all cell clusters that expressed the AtLTP1 luciferase reporter gene developed into a somatic embryo, suggesting that initiation of an embryogenic pathway in tissue culture does not always lead to development of a somatic embryo.
Resume du plan de relocalisation involontaire du projet (2006)

The objective of the Community-Based Watershed Management Project for Mauritania is to lessen the incidence of land degradation at the watershed level within the project areas by assisting rural communities to realize the benefits through community-driven investments, addressing land degradation and promoting sustainable land management practices. Some of the environmental impacts include: soil degradation, water pollution, air pollution, noise nuisance, natural habitats, fauna and flora, communities, and health. Mitigating measures are in the areas of construction, material treatment, latrine implementation, vegetation, reforestation, measures to protect cultural heritage, transport material regulations, water management, and conflict resolution.
Practical and post-quantum authenticated key exchange from one-way secure key encapsulation mechanism (2013)

This paper discusses how to realize practical post-quantum authenticated key exchange (AKE) with strong security, i.e., CK+ security (Krawczyk, CRYPTO 2005). It is known that strongly secure post-quantum AKE protocols exist on a generic construction from IND-CCA secure key encapsulation mechanisms (KEMs) in the standard model.
Efficient Solid-Phase Synthesis of Sulfahydantoins (2002)

A novel solid-phase strategy allows the efficient preparation of "traceless" sulfahydantoins. A total of 28 derivatives, with crude purity generally higher than 85%, were prepared by parallel synthesis. Through reductive alkylations, Mitsunobu reactions, and sulfamoylation reactions on oxime resin, the synthetic strategy affords sulfahydantoin derivatives selectively substituted at N(2), N(5) and N(2), N(5) positions, although yields of disubstituted compounds are lower. The mild reaction conditions involved lead to sulfahydantoins without racemization.
A Large Flowrate Electroosmotic Pump With Micron Pores (2001)

Abstract This paper presents a description of the design, fabrication, and characterization of a novel, high flowrate electroosmotic pump designed for microcooling applications. The prototype pumps demonstrated a flowrate of 7 ml/min for 200 V applied potential that is suitable for two-phase heat exchangers with a capacity approaching 100 W. This pump uses electroosimotic flow (EOF) to drive the flow and is compact with no moving parts. The pump structure is produced by chemically treating and further sintering an ultrafine glass frit (filter). The frits we use are porous cylinders 30 mm in diameter and 3 mm (varying from 1.5 to 3 mm) thick and provide the high wetted-surface-to-volume ratio required to generate pressures exceeding 2 arm. Both deionized (DI) water and buffered aqueous solutions have been used as working fluids. Experiments have been conducted to characterize the pump performance and investigate its physical properties such as the structure porosity, tortuosity, effective pore size, finite double layer effects, and the dependence of zeta potential on ionic conductivity of the working solution.
Transition from Superlithiophobicity to Superlithiophilicity of Garnet Solid-State Electrolyte (2016)

All-solid-state Li-batteries using solid-state electrolytes (SSEs) offer enhanced safety over conventional Li-ion batteries with organic liquid electrolytes due to the nonflammable nature of SSEs. The superior mechanical strength of SSEs can also protect against Li dendrite penetration, which enables the use of the highest specific capacity (3861 mAh/g) and lowest redox potential (-3.04 V vs standard hydrogen electrode) anode: Li metal. However, contact between the Li metal and SSEs presents a major challenge, where a large polarization occurs at the Li metal/SSE interface. Here, the chemical properties of a promising oxide-based SSE (garnet) changed from "super-lithiophobicity" to "super-lithiophilicity" through an ultrathin coating of amorphous Si deposited by plasma-enhanced chemical vapor deposition (PECVD). The wettability transition is due to the reaction between Li and Si and the in situ formation of lithiated Si. As a result, symmetric cells composed of a Si-coated garnet-structured SSE and Li metal electrodes exhibited much smaller impedance and excellent stability upon plating/stripping cycles compared to cells using bare garnet SSE. Specifically, the interfacial resistance between Li and garnet dramatically decreased from 925 to 127 Ω cm(2) when lithiated Si was formed on the garnet. Our discovery of switchable lithiophobic-lithiophilic surfaces to improve the Li metal/SSE interface opens opportunities for improving many other SSEs.
Amphiphilic Poly(acrylamide)s Having Saturated and Unsaturated Dialkyl Chains and Phosphatidylcholine Groups in the Side Chains (1996)

A novel phosphatidylcholine analogous vinyl monomer 1-(acrylamidomethyl)-2‘-(trimethyl ammonio)ethyl phosphate (AMP) was synthesized and characterized. A series of amphiphilic poly(acrylamide)s were obtained from AMP, and some dialkylacrylamide monomers, by radical copolymerization in the presence of α,α‘-azobis(isobutyronitrile) (AIBN). The polyelectrolyte behavior of these copolymers was investigated by their viscosity measurements. Moreover, the structures in condensed phases and thermal properties of these copolymers were investigated by X−ray analysis, DSC measurement, and POM observation. In addition, the phase transitions of monolayers obtained from these amphiphilic copolymers were observed by changing the temperature of the subphase, length of the alkyl chains, and observation times (tob). The LB films were prepared by using the vertical dipping method, and their surface contact angles with pure water were also measured.
On the fundamental limits of Q factor of crystalline dielectric resonators (2007)

The temperature dependence of the processes which fundamentally limit optical quality factor of ideal crystalline whispering gallery mode resonators is investigated. The example of CaF(2) is used to show that spontaneous Raman scattering is the main limitation of the quality factor at low temperatures. Stimulated Raman scattering is also shown to be important at any temperature. We experimentally demonstrate nonlinear absorption due to stimulated Raman scattering in a real cavity at room temperature and theoretically derive Raman gain of CaF(2). We conclude that optical storage times in excess of one second could be achieved in millimeter sized cavities.
Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity (2005)

Human papillomaviruses (HPVs) are small double-stranded DNA viruses that infect the cutaneous and mucosal epithelium. Infection by specific HPV types has been linked to the development of cervical carcinoma. HPV infects epithelial cells that undergo terminal differentiation and so encode multiple mechanisms to override the normal regulation of differentiation to produce progeny virions. Two viral proteins, E6 and E7, alter cell cycle control and are the main arbitrators of HPV-induced oncogenesis. Recent data suggest that E6 and E7 also play a major role in the inhibition of the host cell innate immune response to HPV. The E1 and E2 proteins, in combination with various cellular factors, mediate viral replication. In addition, E2 has been implicated in both viral and cellular transcriptional control. Despite decades of research, the function of other viral proteins still remains unclear. While prophylactic vaccines to block genital HPV infection will soon be available, the widespread nature of HPV infection requires greater understanding of both the HPV life cycle as well as the mechanisms underlying HPV-induced carcinogenesis.