gebhart/patrepeval huggingface dataset:
Characterization of antibodies of high affinity and specificity for the digitalis glycoside digoxin (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of antibodies of high affinity and specificity for the digitalis glycoside digoxinThomas W. Smith, Vincent P. Butler, Jr., and Edgar HaberCite this: Biochemistry 1970, 9, 2, 331–337Publication Date (Print):January 20, 1970Publication History Published online1 May 2002Published inissue 20 January 1970https://pubs.acs.org/doi/10.1021/bi00804a020https://doi.org/10.1021/bi00804a020research-articleACS PublicationsRequest reuse permissionsArticle Views239Altmetric-Citations191LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice. (2000)

Phosphorylation of IkappaB, an inhibitor of NF-kappaB, is an important step in the activation of the transcription factor NF-kappaB. Phosphorylation is mediated by the IkappaB kinase (IKK) complex, known to contain two catalytic subunits: IKKalpha and IKKbeta. A novel, noncatalytic component of this kinase complex called NEMO (NF-kappaB essential modulator)/IKKgamma was identified recently. We have generated NEMO/IKKgamma-deficient mice by gene targeting. Mutant embryos die at E12.5-E13.0 from severe liver damage due to apoptosis. NEMO/IKKgamma-deficient primary murine embryonic fibroblasts (MEFs) lack detectable NF-kappaB DNA-binding activity in response to TNFalpha, IL-1, LPS, and Poly(IC) and do not show stimulus-dependent IkappaB kinase activity, which correlates with a lack of phosphorylation and degradation of IkappaBalpha. Consistent with these data, mutant MEFs show increased sensitivity to TNFalpha-induced apoptosis. Our data provide in vivo evidence that NEMO/IKKgamma is the first essential, noncatalytic component of the IKK complex.
Family history of myocardial infarction as an independent risk factor for coronary heart disease. (1985)

The hypothesis that a family history of heart attack before the age of 60 years is an independent risk factor for coronary heart disease was examined in a random sample of 1044 men aged 40-70. Data on personal and family history, smoking, weight, height, plasma lipid and lipoprotein concentrations, blood pressure, and resting and exercise electrocardiograms were collected according to the standard Lipid Research Clinics protocol. A history of heart attack in first degree relatives was ascertained by interviewing the participants. Evidence of coronary heart disease was found in 123 men (reported heart attack in 20, electrocardiographic findings of ischaemic heart disease at rest in 40, and electrocardiographic findings during heart rate limited exercise in 63). Subjects with coronary heart disease had considerably higher concentrations of total cholesterol, higher blood pressures, and lower concentrations of high density lipoprotein cholesterol than those without. Twenty nine per cent of the subjects with coronary heart disease reported a history of heart attack in a first degree relative before 60 years of age compared with 19% of those without. In a multivariate logistic model, the coefficients for age, cholesterol concentrations, and hypertension were all positive and statistically significant. The coefficient for HDL cholesterol concentration was negative and significant. A family history of heart attack showed a significant positive association, indicating a relation with coronary heart disease that is independent of the other variables in the model. The relation persisted in apparently asymptomatic patients with coronary heart disease.
A New Artificial Neural Network Approach in Solving Inverse Kinematics of Robotic Arm (Denso VP6242) (2016)

This paper presents a novel inverse kinematics solution for robotic arm based on artificial neural network (ANN) architecture. The motion of robotic arm is controlled by the kinematics of ANN. A new artificial neural network approach for inverse kinematics is proposed. The novelty of the proposed ANN is the inclusion of the feedback of current joint angles configuration of robotic arm as well as the desired position and orientation in the input pattern of neural network, while the traditional ANN has only the desired position and orientation of the end effector in the input pattern of neural network. In this paper, a six DOF Denso robotic arm with a gripper is controlled by ANN. The comprehensive experimental results proved the applicability and the efficiency of the proposed approach in robotic motion control. The inclusion of current configuration of joint angles in ANN significantly increased the accuracy of ANN estimation of the joint angles output. The new controller design has advantages over the existing techniques for minimizing the position error in unconventional tasks and increasing the accuracy of ANN in estimation of robot’s joint angles.
Improved barrier films of cross-linked cellulose nanofibrils: a microscopy study (2014)

It is highly desirable to replace gas barriers of aluminium and non-renewable plastics in order to lower our ecological footprint. One interesting candidate is films made from cellulose nanofibrils (CNFs), which after cross-linking have been shown to have competitive barrier properties even at a high relative humidity (80% RH). This work presents studies at even higher relative humidity (90% RH) and microscopic studies of what happens when unmodified and cross-linked CNF films are exposed to water. The microscopy techniques used were scanning electron microscopy of dry and wet cross-sections of films after freeze-drying and atomic force microscopy in the dry state and in the wet state shortly after wetting. Both techniques clearly revealed that the cross-links prevent the CNFs from separating from each other and hence prevent the films from swelling, so that the free-volume-sensitive gas permeability is maintained at a low level.
Uniformly redundant arrays: digital reconstruction methods (1981)

Several new digital reconstruction techniques for coded aperture imaging are developed which are especially applicable to uniformly redundant arrays (URAs). The techniques provide improved resolution without upsetting the artifact-free nature of URAs. Two new techniques are described; one which allows self-supporting URAs and one which avoids (or at least mitigates) a blur which has been associated with previous correlation analyses. Each of the methods and their resolution improvements are demonstrated with reconstructions of a laser-driven compression. Particular emphasis has been placed on the special sampling required of the encoded picture and the decoding function if artifacts are to be avoided. For large URAs, it is shown that another new digital technique, periodic decoding, is much faster. Periodic decoding does produce artifacts, but they usually are negligible.
Mixed-Reality Simulation of Minimally Invasive Surgeries (2007)

Our mixed-reality platform helps train surgeons in minimally invasive surgery and objectively assesses their performance. The platform uses multicamera stereo inside a patient manikin to measure the 3D positions of unmodified surgical instruments. It uses this information to drive a mixed-reality, computer-mediated learning system and provide objective measures of surgical skill.
Electron emission and structure properties of cesiated carbon films prepared by negative carbon ion beam (1997)

The work function, field emission property (turn-on field), and Auger electron spectroscopy of cesiated carbon films on Si (100) have been investigated for codeposition of Cs neutral and C− ion beams at different energies (25–150 eV). The higher energy (150 eV) C− ion beam produces the lower work function surface (1.1 eV) as well as sp3 rich carbon film. The work function depends both on cesium concentration as well as on the sp3 fraction in the carbon films. The turn-on field of the film can be as low as 7 V/μm. The thermal stability of the low work function surface has been investigated for postdeposition annealing up to 600 °C. An extremely high stability cold cathode has been made by forming cesium carbide.
Samarium(II) Iodide Reduction of Isoxazolidines. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Hybrid Data-Sharing and Compression Strategy for Downlink Cloud Radio Access Network (2018)

This paper studies transmission strategies for the downlink of a cloud radio access network, in which the base stations are connected to a centralized cloud-computing based processor with digital fronthaul or backhaul links. We provide a system-level performance comparison of two fundamentally different strategies, namely the data-sharing strategy and the compression strategy, that differ in the way the fronthaul/backhaul is utilized. It is observed that the performance of both strategies depends crucially on the available fronthaul or backhaul capacity. When the fronthaul/backhaul capacity is low, the datasharing strategy performs better, while under moderate-to-high fronthaul/backhaul capacity, the compression strategy is superior. Using insights from such a comparison, we propose a novel hybrid strategy, combining the data-sharing and compression strategies, that allows for better control over the fronthaul/backhaul capacity utilization. An optimization framework for the hybrid strategy is proposed. Numerical evidence demonstrates the performance gain of the hybrid strategy.
Circulating antiovarian antibodies in premature ovarian failure. (1986)

The presence of antiovarian antibodies in sera of women with premature ovarian failure was determined by an indirect fluorescent antibody assay using human ovarian tissue. Of 27 patients, 14 had positive ovarian fluorescence, compared with zero of 24 normal cycling controls (P less than .001) and one of 22 postmenopausal controls (P less than .01). In patients with autoimmune diseases, five of 17 demonstrated positive fluorescence compared with zero of 24 premenopausal controls (P less than .01). Immunoperoxidase staining revealed antigen concentrated at the granulosa cells and oocyte in nine of the 14 ovarian failure cases. The finding that a significant proportion of patients with premature ovarian failure have circulating antiovarian antibodies confirms previous studies, but localization of peroxidase staining to granulosa cells and/or oocytes represents a new finding in this study.
2D Statistical Models of Facial Expressions for Realistic 3D Avatar Animation (2005)

We address the issue of modelling facial expressions for realistic 3D avatar animation. We introduce a hierarchical decomposition of a human face into different components and model them according to their intrinsic functionalities. The parametrisation of the expressions is achieved in a two-level framework. First level accounts for the low level component facial actions and is represented by hierarchical latent variable models. The second level models the final expressions as a combination of subcomponent information extracted from the lower level using combinatorial logic. Finally we produce continuous animation curves that are used to animate 3D avatar in a morph-based fashion. Our approach is entirely based on 2D information extracted from the input source.
Global Expression Profile of Highly Enriched Cardiomyocytes Derived from Human Embryonic Stem Cells (2009)

Human embryonic stem cells (hESC), with their ability to differentiate into cardiomyocytes in culture, hold great potential for cell replacement therapies and provide an in vitro model of human heart development. A genomewide characterization of the molecular phenotype of hESC-derived cardiomyocytes is important for their envisioned applications. We have employed a lineage selection strategy to generate a pure population of cardiomyocytes (>99%) from transgenic hESC lines. Global gene expression profiling showed that these cardiomyocytes are distinct from pluripotent and differentiated hESC cultures. Pure cardiomyocytes displayed similarities with heart tissue, but in many aspects presented an individual transcriptome pattern. A subset of 1,311 cardiac-enriched transcripts was identified, which were significantly overpresented (p < .01) in the Gene Ontology (GO) categories of heart function and heart development. Focused analysis of the GO categories ion transport, sarcomere, and heart development uncovered a unique molecular signature of hESC cardiomyocytes. Pathway analysis revealed an extensive cardiac transcription factor network and novel peroxisome proliferator-activated receptor signaling components within the cardiac-enriched genes. Notably, approximately 80% of these genes were previously uncharacterized. We have evaluated the biological relevance of four candidates-Rbm24, Tcea3, Fhod3, and C15orf52-by in situ hybridization during early mouse development and report that all were prominently expressed in cardiac structures. Our results provide the fundamental basis for a comprehensive understanding of gene expression patterns of hESC cardiomyocytes and will greatly help define biological processes and signaling pathways involved in hESC cardiomyogenic differentiation and in human heart development.
Genetic Diversity among <i>Borrelia</i> Strains Determined by Single-Strand Conformation Polymorphism Analysis of the <i>ospC</i> Gene and Its Association with Invasiveness (2003)

Lyme borreliosis (LB) is a tick-borne spirochetal infection caused by three Borrelia species: Borrelia afzelii, B. garinii, and B. burgdorferi sensu stricto. LB evolves in two stages: a skin lesion called erythema migrans and later, different disseminated forms (articular, neurological, cardiac.). Previous research based on analysis of ospC sequences allowed the definition of 58 groups (divergence of <2% within a group and >8% between groups). Only 10 of these groups include all of the strains isolated from disseminated forms that are considered invasive. The aim of this study was to determine whether or not invasive strains belong to restricted ospC groups by testing human clinical strains isolated from disseminated forms. To screen for ospC genetic diversity, we used single-strand conformation polymorphism (SSCP) analysis. Previously known ospC sequences from 44 different strains were first tested, revealing that each ospC group had a characteristic SSCP pattern. Therefore, we studied 80 disseminated-form isolates whose ospC sequences were unknown. Of these, 28 (35%) belonged to previously known invasive groups. Moreover, new invasive groups were identified: six of B. afzelii, seven of B. garinii, and one of B. burgdorferi sensu stricto. This study confirmed that invasive strains are not distributed among all 69 ospC groups but belong to only 24 groups. This suggests that OspC may be involved in the invasiveness of B. burgdorferi.
Apoptosis. Its significance in cancer and cancer Therapy (1994)

Apoptosis is a distinct mode of cell death that is responsible for deletion of cells in normal tissues; it also occurs in specific pathologic contexts. Morphologically, it involves rapid condensation and budding of the cell, with the formation of membrane-enclosed apoptotic bodies containing well-preserved organelles, which are phagocytosed and digested by nearby resident cells. There is no associated inflammation. A characteristic biochemical feature of the process is double-strand cleavage of nuclear DNA at the linker regions between nucleosomes leading to the production of oligonucleosomal fragments. In many, although not all of the circumstances in which apoptosis occurs, it is suppressed by inhibitors of messenger RNA and protein synthesis. Apoptosis occurs spontaneously in malignant tumors, often markedly retarding their growth, and it is increased in tumors responding to irradiation, cytotoxic chemotherapy, heating and hormone ablation. However, much of the current interest in the process stems from the discovery that it can be regulated by certain proto-oncogenes and the p53 tumor suppressor gene. Thus, c-myc expression has been shown to be involved in the initiation of apoptosis in some situations, and bcl-2 has emerged as a new type of proto-oncogene that inhibits apoptosis, rather than stimulating mitosis. In p53-negative tumor-derived cell lines transfected with wild-type p53, induction of the gene has, in rare cases, been found to cause extensive apoptosis, instead of growth arrest. Finally, the demonstration that antibodies against a cell-surface protein designated APO-1 or Fas can enhance apoptosis in some human lymphoid cell lines may have therapeutic implications.
&lt;title&gt;PackBot: a versatile platform for military robotics&lt;/title&gt; (2004)

The iRobot PackBot is a combat-tested, man-portable UGV that has been deployed in Afghanistan and Iraq. The PackBot is also a versatile platform for mobile robotics research and development that supports a wide range of payloads suitable for many different mission types. In this paper, we describe four R&D projects that developed experimental payloads and software using the PackBot platform. CHARS was a rapid development project to develop a chemical/radiation sensor for the PackBot. We developed the CHARS payload in six weeks and deployed it to Iraq to search for chemical and nuclear weapons. Griffon was a research project to develop a flying PackBot that combined the capabilities of a UGV and a UAV. We developed a Griffon prototype equipped with a steerable parafoil and gasoline-powered motor, and we completed successful flight tests including remote-controlled launch, ascent, cruising, descent, and landing. Valkyrie is an ongoing research and development project to develop a PackBot payload that will assist medics in retrieving casualties from the battlefield. Wayfarer is an applied research project to develop autonomous urban navigation capabilities for the PackBot using laser, stereo vision, GPS, and INS sensors.
Mechanical failure of the Intramedullary Skeletal Kinetic Distractor in limb lengthening (2011)

Between October 2001 and September 2009 we lengthened 242 lower-limb segments in 180 patients using the Intramedullary Skeletal Kinetic Distractor (ISKD). Mechanical failure was defined either as breakage of the ISKD or failure of the internal mechanism to activate. Retrieved nails which failed mechanically were examined by the manufacturer for defects. In all, 15 ISKDs in 12 patients (13 limbs) failed mechanically representing an overall failure rate of 6.2%, with fracture of the device occurring in ten of the 15 failures. Two nails in one patient failed to lengthen and had to be replaced. The manufacturer detected an error in the assembly of the nail, which prompted a wide recall. One nail jammed after being forcefully inserted, and two nails failed to lengthen fully. Lengthening was achieved in all 12 patients, although three required a second operation to exchange a defective nail for a new, functioning device. The ISKD is a complex mechanical device which lengthens by the oscillation of two telescopic sections connected by a threaded rod. The junction between these sections is surrounded by a keyring collar. This keyring collar is the weakest part of the device.
Chitinase-Like Proteins Are Autoantigens in a Model of Inflammation-Promoted Incipient Neoplasia (2011)

An important role for B cells and immunoglobulin deposition in the inflammatory tumor cell environment has been recognized in several cancers, and this is recapitulated in our murine model of inflammation-associated carcinogenesis: transgenic mice expressing the Epstein-Barr virus oncogene LMP1 in epithelia. Similarly in several autoimmune disorders, immunoglobulin deposition represents a key underlying event in the disease process. However, the autoantigens in most cases are not known. In other studies, overexpression of the enzymatically inactive mammalian chitinase-like proteins (CLPs) has been observed in a number of autoimmune disorders and numerous cancers, with expression correlated with poor prognosis, although the function of these proteins is largely unknown. We have now linked these observations demonstrating that overexpression of the CLPs renders them the targets for autoantigenicity during carcinogenic progression. We show that the CLPs, Chi3L1, Chi3L3 /YM1, and Chi3L4/YM2, are abundantly overexpressed in the transgenic epidermis at an early, preneoplastic stage and secreted into the serum. Immunoglobulin G reactive to the CLPs is detected in the serum and deposited in the hyperplastic tissue, which goes on to become inflamed and progressively displastic. The CLPs are also upregulated in chemical carcinogen-promoted lesions in both transgenic and wild-type mice. Expression of the related, active chitinases, Chit1 and AMCase, increases following infiltration of inflammatory cells. In this model, the 3 CLPs are autoantigens for the tissue-deposited immunoglobulin, which we propose plays a causative role in promoting the inflammation-associated carcinogenesis. This may reflect their normal, benign function to promote tissue remodeling and to amplify immune responses. Their induction during carcinogenesis and consequent autoantigenicity provides a missing link between the oncogenic event and subsequent inflammation. This study identifies the CLPs as important and novel therapeutic targets to limit inflammation in cancer and potentially also autoimmune disorders.
Ventriculofemoroatrial shunt: a viable alternative for the treatment of hydrocephalus (1997)

Children with shunted hydrocephalus often have a myriad of other medical conditions. When these concomitant problems involve the pleura, peritoneum, and/or the venous system, placement of the distal catheter may prove to be problematic. This report presents preliminary results in three hydrocephalic children following ventriculofemoroatrial shunt placement. The peritoneal and pleural cavities in each of these children were compromised and there was no vascular access into the superior vena cava due to intercurrent disease. An alternative technique for ventriculoperitoneal shunt placement was performed via the femoral vein. Fluoroscopic guidance was used to confirm the intraatrial position of the distal end of the shunt catheter. Follow-up review to date shows no complications. This newly described technique provides a feasible alternative to distal shunt catheter placement in patients in whom more traditional sites are unavailable.