gebhart/patrepeval huggingface dataset:
Hereditary cerebral haemorrhage with amyloidosis, Dutch type (HCHWA-D): clinicopathological studies. (1995)

Clinical and neuropathological findings are reported in 63 patients with hereditary cerebral haemorrhage with amyloid angiopathy. Patients had mostly recurrent strokes, and at least 80% of these were haemorrhages. Almost a third of the patients died within a year of their first and only recorded haemorrhage, half of them within two weeks. This angiopathy was restricted to the cerebral and cerebellar cortex and its covering leptomeninges. As the most important consequence, haemorrhagic infarcts and haemorrhages occurred in the subcortical white matter--that is, the region most vulnerable to impaired cortical circulation. Further development of these subcortical lesions gives rise to the fatal haemorrhages seen at necropsy. In so far as dementia occurs this is likely to result from multiple microinfarcts or haemorrhages. In most cases preamyloid lesions or diffuse plaques and early plaques were seen. No other type of plaque or neurofibrillary degeneration was found. The plaques occur in conjunction with the angiopathy, but may not occur even when the angiopathy is severe. In one patient plaques were totally absent. Angiopathy and plaques may be the result of the same mutation, the expression of which is governed by tissue factors or phenotypic differences between individual subjects.
Cytokines and Myocardial Regeneration (2008)

The regenerative capacity of the myocardium and its blood vessels has now been well demonstrated. The cytokines granulocyte colony-stimulating factor, erythropoietin, and stem cell factor may play a role in helping to stimulate cell regeneration under normal physiologic conditions and in patients with myocardial injury. After an ischemic insult, cytokines are released into the peripheral circulation and signal for the mobilization of stem cells. In experimental cardiac injury models, the addition of cytokines has been shown to improve myocardial function with and without the concurrent use of stem cell therapy. Preliminary studies in humans using cytokine therapy alone for treating myocardial infarction have been disappointing. Future studies in patients with myocardial injury need to examine the use of various combinations of cytokines, with and without the addition of intravascular stem cell infusions or direct stem cell injections.
Multicenter Phase II Study of Brequinar Sodium in Patients with Advanced Breast Cancer (1993)

In this study, 34 patients with advanced breast cancer were treated with brequinar sodium: 75% of the patients were postmenopausal, and 94% had received chemotherapy previously; 50% had previously received an anthracycline-containing regimen. Brequinar was administered intravenously at a median weekly dose of 1,200 mg/m2. The toxicity was moderate, with 17 patients (50%) experiencing grade 3 or 4 toxicity. There were 33 patients evaluable for response: 4 patients (12%; 95% confidence interval, 3.4-28.2%) achieved partial responses, 10 patients (30%) were stable, and 19 patients (58%) had progressive disease. We conclude that, at this dose and schedule, brequinar has only modest activity in patients with advanced breast cancer.
Application of Al/PI composite bumps to COG bonding process (2001)

This work demonstrates the probing, testability and applicability of Al/PI (aluminum/polyimide) composite bumps to the chip on-glass (COG) bonding process for liquid crystal display (LCD) driver chip packaging. The experimental results showed that the thickness of Al overlayer on PI core of the bump, the location of pin contact, and the bump configuration affect bump probing testability. The bump with type IV configuration prepared in this work exhibited excellent probing testability when its Al overlayer thickness exceeded 0.8 /spl mu/m. We further employed Taguchi method to identify the optimum COG bonding parameters for the Al/PI composite bump. The four bonding parameters, bonding temperature, bonding time, bonding pressure and thickness of Al overlayer are identified as 180/spl deg/ C, 10 s, 800 kgf/cm/sup 2/ and 1.4 /spl mu/m, respectively. The optimum bonding condition was applied to subsequent COG bonding experiments on glass substrates containing Al pads or indium tin oxide (ITO) pads. From the results of resistance measurement along with a series of reliability tests, Al pad is found to be a good substrate bonding pad for Al/PI bump to COG process. Excellent contact quality was observed when the bumps had Al overlayer thickness over 1.1 /spl mu/m. As to the COG specimens with substrate containing ITO pads, high joint resistance suggested that further contact quality refinement is necessary to realize their application to COG process.
A COMPARISON OF BITTER PERCEPTION IN HIGH-ALCOHOL, LOW-ALCOHOL AND ALCOHOL-FREE BEER (1996)

A trained sensory panel (N=17) evaluated three commercial beer products by flavour profiling using 14 descriptors. Bitterness was investigated further by HPLC and sensory measurements. Time-intensity curves for five repeated ingestions of each beer showed bitterness either increasing with ingestion or decreasing, depending on the beer and panellist. Generally speaking, a decline in bitterness over time was perceived more often when the beer was one of those considered initially to be more bitter. For the purposes of comparison, a fourth product (AMplus) was prepared by adding iso-α-acids to Amstel Malt, the alcohol-free beer evaluated. Consumer tests (N=138) showed no difference in preference between Amstel Malt and AMplus. Hypotheses regarding bitterness preference as a function of gender, age or regularity of beer consumption could not be supported.
A feature interaction benchmark for {IN} and beyond (1994)

. Rapid creation of new services for telecommunications systems is hindered by the feature interaction problem. This is an important issue for development of IN services, not only because of interactions among IN services themselves but because of interactions of IN services with switch-based services and potential interactions with services not yet developed. Furthermore, the problem is fundamental to service creation; it is not restricted to IN services. Any platform for telecommunication services requires a method for dealing with the feature interaction problem. A number of approaches for managing feature interactions have been proposed. However, lack of structured ways to categorize feature interactions makes it difficult to determine if a particular approach has addressed some, if not all, classes of interactions. We describe and analyze a number of feature interactions by using two independent classification schemes. This paper is a step to achieving the goal of a coherent indus...
Synthetic gecko foot-hair micro/nano-structures as dry adhesives (2003)

Abstract This paper proposes techniques to fabricate synthetic gecko foot-hairs as dry adhesives for future wall-climbing and surgical robots, and models for understanding the synthetic hair design issues. Two nanomolding fabrication techniques are proposed: the first method uses nanoprobe indented flat wax surface and the second one uses a nano-pore membrane as a template. These templates are molded with silicone rubber, polyimide, etc. type of polymers under vacuum. Next, design parameters such as length, diameter, stiffness, density, and orientation of hairs are determined for non-matting and rough surface adaptability. Preliminary micro/nano-hair prototypes showed adhesion close to the predicted values for natural specimens (around 100 nN each). Keywords: BIOMIMETIC ADHESIVESPRESSURE CONTROLLED DRY ADHESIVESADHESION FORCESPOLYMER MICRO NANO-FABRICATIONMICRO NANO-ROBOTICSNANOINDENTATIONAND NANOMOLDING
Immunoglobulin secretion by cell lines derived from African and American undifferentiated lymphomas of Burkitt's and non-Burkitt's type. (1982)

As part of an investigation of the cellular origins of undifferentiated lymphomas of the Burkitt's and non-Burkitt's types, we have examined immunoglobulin secretion by cell lines and biopsy samples from these tumors and have compared it with other lymphoblastoid cell lines. The majority of American lymphoma cell lines and a smaller fraction of African lymphoma cell lines secreted monoclonal IgM. No other Ig classes were secreted. Ig secretion by the tumor samples was also found to be exclusively IgM. The secreted IgM was polymeric and associated with J chain. Secretion of free light chain by most of the tumor cell lines was observed. Quantitation by immunoassay demonstrated that the American lymphoma cell lines secreted significantly more IgM than the African lymphoma cell lines. We have proposed that the lymphoma cells represent an early stage of B cell differentiation, during which antigen-independent secretion occurs.
Targeting the p53 pathway to protect the neonatal ischemic brain (2011)

We are the first to show that prevention of mitochondrial p53 association by PFT-μ strongly improves functional outcome and decreases lesion size after neonatal HI. PFT-μ not only inhibits mitochondrial release of cytochrome c, but also inhibits oxidative stress. We propose that as a consequence nuclear accumulation of p53 and transcription of proapoptotic target genes are prevented. In conclusion, targeting p53 mitochondrial association by PFT-μ may develop into a novel and powerful neuroprotective strategy.
Identification and characterization of a soluble form of the plasma cell membrane glycoprotein PC‐1 (5′‐nucleotide phosphodiesterase) (1993)

PC‐1 is a membrane glycoprotein, found on the surface of plasma cells and a few types of non‐lymphoid cells, which has recently been found to have 5′‐nucleotide phosphodiesterase activity. In this paper, we demonstrate the existence of enzymically active water‐soluble forms of PC‐1 in ascites from plasmacytoma‐bearing mice, normal mouse serum, and in supernatants of cultured mouse plasmacytoma cells and mouse L cells transfected with a cDNA encoding the membrane form of PC‐1. The water‐soluble enzyme activity can be specifically immunoprecipitated by a monoclonal antibody to an allotypic determinant on the membrane form of PC‐1, and resides on a slightly smaller polypeptide than membrane PC‐1. Biosynthetic studies revealed a single, mono‐meric, endoglycosidase‐H‐sensitive membrane PC‐1. precursor, which was gradually converted to a disulphide‐bonded, endoglycosidase‐H‐resistant form over a period of about 2 h. Soluble PC‐1 was first detectable in the supernatant after about 2 h. A distinct intracellular form of soluble PC‐1 was not seen. The soluble form of PC‐1 does not appear to arise by proteolytic cleavage from the cell surface, although cleavage inside the cell remains a possibility. When taken together with the structure of the relevant portions of PC‐1 gene exons, the data suggest that the most likely site of cleavage is between Pro152 and Ala153.
Factor XIII in Ulcerative Leg Disease: Background and Preliminary Clinical Results (1996)

The therapy concept of topical factor XIII application was developed on the basis of clinical and experimental investigations on improvement of wound healing, as well as on the morphological and pathophysiological topical site of venous ulcers. Topical treatment with factor XIII is special with regard to mode of application as well as efficacy, since a lot of other medications used for local wound treatment contain a fibrinolytic component. In the last 32 months, 23 inpatients (17 female, 6 male) averaging 62.9 +/- 14.1 years and suffering ulcerative leg disease were treated with topically applied factor XIII. The average period of distal venous ulcer in these patients was 3.3 +/- 2.04 years. The extent of the ulcer surface ranged between 2.5 x 3.0 cm (minimum) and 18.5 x 8.0 cm (maximum). All patients had been in medical consultation for several years. The venous ulcers were based upon a "postthrombotic syndrome" in 15 patients. Six patients were suffering from ulcerations due to arterial and venous mixed disease, and there were 2 patients with ulcerations of unknown etiology. In 5 patients, 2 with unknown etiology and 3 with arterial and venous mixed disease, local treatment with factor XIII was discontinued after 4 weeks because there was definitely no improvement in wound healing. Additionally, 3 patients with ulcerations due to arterial and venous mixed disease were treated for a maximum of 6 weeks with only moderate improvement in healing. Twelve of the 15 patients (79.3%) with extended, chronic ulceration on the basis of a postthrombotic syndrome showed such a distinct improvement of topical site after an average of only 3.15 +/- 1.14 weeks that they were released for further ambulatory treatment. Three patients had to be treated for a maximum period of 6 weeks, also with distinct improvement in wound healing. Apart from a wound surface reduction and a clinically documentable improvement of granulation tendency, there was a marked reduction of secretion and bleeding tendency within the ulcer area observed in all patients. None of the patients showed any systemic or local allergic reactions.
Honor thy symbionts (2003)

Our intestine is the site of an extraordinarily complex and dynamic environmentally transmitted consortial symbiosis. The molecular foundations of beneficial symbiotic host-bacterial relationships in the gut are being revealed in part from studies of simplified models of this ecosystem, where germ-free mice are colonized with specified members of the microbial community, and in part from comparisons of the genomes of members of the intestinal microbiota. The results emphasize the contributions of symbionts to postnatal gut development and host physiology, as well as the remarkable strategies these microorganisms have evolved to sustain their alliances. These points are illustrated by the human-Bacteroides thetaiotaomicron symbiosis. Interdisciplinary studies of the effects of the intestinal environment on genome structure and function should provide important new insights about how microbes and humans have coevolved mutually beneficial relationships and new perspectives about the foundations of our health.
Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex (2000)

Little is known about regionally specific signals that control the number of neuronal progenitor cells in vivo. We have previously shown that the germline mutation of the basic fibroblast growth factor (Fgf2) gene results in a reduction in the number of cortical neurons in the adult. We show here that Fgf2 is expressed in the pseudostratified ventricular epithelium (PVE) in a dorsoventral gradient and that Fgf2 and its receptor, Fgfr-1, are downregulated by mid to late stages of neurogenesis. In Fgf2 knockout mice, the volume and cell number of the dorsal PVE (the cerebral cortical anlage) are substantially smaller, whereas the volume of the basal PVE is unchanged. The dorsal PVE of Fgf2 knockout mice has a 50% decrease in founder cells and a reduced expansion of the progenitor pool over the first portion of neurogenesis. Despite this reduction, the degree of apoptosis within the PVE is not changed in the Fgf2 knockouts. Cortical neuron number was decreased by 45% in Fgf2 knockout mice by the end of neurogenesis, whereas the number of neurons in the basal ganglia was unaffected. Microscopically, the frontal cerebral cortex of neonatal Fgf2 null mutant mice lacked large neurons in deep cortical layers. We suggest that Fgf2 is required for the generation of a specific class of cortical neurons arising from the dorsal PVE.
Accelerating Video-Mining Applications Using Many Small, General-Purpose Cores (2008)

Emerging video-mining applications such as image and video retrieval and indexing will require real-time processing capabilities. A many-core architecture with 64 small, in-order, general-purpose cores as the accelerator can help meet the necessary performance goals and requirements. The key video-mining modules can achieve parallel speedups of 19times to 62times from 64 cores and get an extra 2.3times speedup from 128-bit SIMD vectorization on the proposed architecture.
Cerebrospinal fluid shunts: flow measurements with MR imaging. (1989)

The authors describe a technique for determination of shunt patency by quantifying cerebrospinal fluid shunt flow rates with magnetic resonance (MR) imaging. This method uses a modified clinical sequence that is both sensitive to slow flow perpendicular to the imaging plane and capable of achieving oblique angles with a 4-cm field of view. Velocity-dependent phase images were used to quantify flow rates within the shunt. A preliminary study was performed in seven patients with hydrocephalus and cerebrospinal fluid shunts. Two patients were found to have zero flow in the shunt, while the remaining five had flow rates ranging from 4 to 19 mL/h. Results showed that the measurement of flow rates within the shunt lumen with MR imaging is clinically feasible.
An Updated Meta-Analysis of Randomized Controlled Trials Assessing the Effect of Sorafenib in Advanced Hepatocellular Carcinoma (2014)

Treatment with sorafenib significantly improved OS and TTP in patients with advanced HCC. Additional large-scale, well-designed RCTs are needed to evaluate the efficacy of sorafenib-based therapy in the treatment of advanced HCC.
Nucleotide sequence of the human pancreatic trypsinogen III cDNA (1990)

Journal Article Nucleotide sequence of the human pancreatic trypsinogen III cDNA Get access Tokio Tani, Tokio Tani * Bioscience Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140, Japan * To whom correspondence should be addressed at Department of Biology, Faculty of Science, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Ichiro Kawashima, Ichiro Kawashima Bioscience Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Katsuko Mita, Katsuko Mita Bioscience Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Yo Takiguchi Yo Takiguchi Bioscience Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 18, Issue 6, 25 March 1990, Page 1631, https://doi.org/10.1093/nar/18.6.1631 Published: 25 March 1990 Article history Received: 14 February 1990 Published: 25 March 1990
Hydroxylated Hydrocinnamides as Hypocholesterolemic Agents (2007)

Several hydroxylated cinnamic acid derivatives were prepared from the corresponding acids and amino acid residues, and their hypocholesterolemic activities were evaluated in high cholesterol-fed mice. The presence of the double bond in hydroxylated cinnamide derivatives decreases cholesterol-lowering activities and the number of free phenolic hydroxy groups affect greatly the activities. 3,4-Dihydroxy hydrocinnamides obtained from amino acid derivatives containing a hydrophobic side chain such as alanine, valine, phenylalanine, and isoleucine exhibited potent cholesterol-lowering activities.
21 tRNA Splicing: An RNA World Add-on or an Ancient Reaction? (1999)

Introns are encoded in the genes for tRNA in organisms from all three kingdoms of life. Their removal is an essential step in the maturation of tRNA precursors. In Bacteria, introns are self-splicing and are removed by a group 1 splicing mechanism (Kuhsel et al. 1990; Reinhold-Hurek and Shub 1992; Biniszkiewicz et al. 1994). In Eukaryotes and Archaea, intron removal is mediated enzymatically by proteins. Recent progress in understanding both eukaryotic and archaeal tRNA splicing has revealed that the two processes, previously thought to be unrelated, are in fact similar. Insight gained from the comparison has provided a clearer understanding of intron recognition, the catalysis of intron removal, and has given new insight into the evolution of the tRNA splicing process. INTRON-CONTAINING tRNA tRNA Introns in Eukaryotes Intervening sequences (introns) were discovered 20 years ago in the yeast genes for the tyrosine-inserting non-sense suppressor tRNA (Goodman et al. 1977) and for tRNA Phe (Valenzuela et al. 1978). With the completion of the yeast genome, it is known that of the 274 yeast tRNA genes 61, or 20%, contain introns. Table 1 lists the tRNAs that contain introns. PCR cloning of tRNAs from higher eukaryotes has revealed a similar distribution of intron-containing tRNA (Stange and Beier 1986; Green et al. 1990; Schneider et al. 1993). The introns in all of the genes are small (14–60 bases), and they are all located in the same position, one base to the 3′ side of the anticodon (Fig. 1A). Structure probing revealed that the...
Spectrally-Precoded OFDM for 5G Wideband Operation in Fragmented sub-6GHz Spectrum (2016)

We consider spectrally-precoded OFDM waveforms for 5G wideband transmission in sub-6GHz band. In this densely packed spectrum, a low out-of-band (OOB) waveform is a critical 5G component to achieve the promised high spectral efficiency. By precoding data symbols before OFDM modulation, it is possible to achieve extremely low out-of-band emission with very sharp spectrum transition enabling an efficient and flexible usage of frequency resources. Spectrally-precoded OFDM shows promising results for reaching 5G targets in high-data rate enhanced mobile broadband and ultra-reliable low-latency communications use cases. Spectral precoding is particularly efficient for wideband transmission enabling short-time transmission, which will often require flexible fragmented spectrum usage.
A straightforward protocol for the preparation of high performance microarray displaying synthetic MUC1 glycopeptides (2013)

The present approach would greatly accelerate the discovery research of new class autoantibodies as well as the development of therapeutic mAbs reacting specifically with disease-relevant epitopes.
DDSOS: A Dynamic Distributed Service-Oriented Simulation Framework1 (2006)

This paper presents the DDSOS framework developed at Arizona State University, which supports the simulation, development, and evaluation of large scale distributed systems such as network-centric and system-of-systems applications. The distinct features of the framework include automated simulation code generation from the specification, code deployment, simulation of different architectures with a template-based platform builder, service-oriented multi-agent simulation for easy reconfiguration, and dynamic analyses of results from evaluation and monitoring. The framework and the associated tools have been implemented and applied in several governmental and industrial projects.