gebhart/patrepeval huggingface dataset:
Parameter-Aware I/O Management for Solid State Disks (SSDs) (2011)

Solid state disks (SSDs) have many advantages over hard disk drives, including better reliability, performance, durability, and power efficiency. However, the characteristics of SSDs are completely different from those of hard disk drives with rotating disks. To achieve the full potential performance improvement with SSDs, operating systems or applications must understand the critical performance parameters of SSDs to fine-tune their accesses. However, the internal hardware and software organizations vary significantly among SSDs and, thus, each SSD exhibits different parameters which influence the overall performance. In this paper, we propose a methodology which can extract several essential parameters affecting the performance of SSDs, and apply the extracted parameters to SSD systems for performance improvement. The target parameters of SSDs considered in this paper are 1) the size of read/write unit, 2) the size of erase unit, 3) the size of read buffer, and 4) the size of write buffer. We modify two operating system components to optimize their operations with the SSD parameters. The experimental results show that such parameter-aware management leads to significant performance improvements for large file accesses by performing SSD-specific optimizations.
THE ESSENCE OF CHAOS (1993)

Glimpses of chaos a journey into chaos our chaotic weather encounters with chaos what else is chaos?
Bromine-76-metabromobenzylguanidine: a PET radiotracer for mapping sympathetic nerves of the heart. (1993)

Iodine-123-metaiodobenzylguanidine (MIBG) is used to qualitatively assess heart innervation with single-photon emission computed tomography (SPECT). This approach is clinically useful in the prognostic evaluation of congestive heart failure. To improve quantification of uptake of the tracer using positron emission tomography (PET), we studied the characteristics of the bromoanalog of MIBG. Bromine-76-metabromobenzylguanidine (76Br-MBBG) was prepared from a heteroisotopic exchange between radioactive bromine atoms (noncarrier-added (76Br) BrNH4) and the cold iodine atoms of the precursor metaiodobenzylguanidine. Biodistribution was studied in rats and PET cardiac imaging performed in dogs. Myocardial uptake was high and prolonged in both species (mean half-life in dogs: 580 min). In rats, myocardial uptake was inhibited by desipramine by 64%, whereas after pretreatment with 6-hydroxydopamine uptake was reduced by 84%. In dogs pretreated with 6-hydroxydopamine or with desipramine, a steep washout of the tracer occurred (mean half-life: 136 min and 118 min, respectively). The non-specific uptake plus the passive neuronal diffusion of the tracer could be estimated at about 25%-30% of the total fixation. In dogs, analysis of unchanged 76Br-MBBG in plasma showed that radiotracer metabolism was slow: 60 min after injection, 80% of the radioactivity was related to unchanged 76Br-MBBG. These preliminary findings suggest that 76Br-MBBG could be used to quantitatively assess adrenergic innervation in heart disease using PET. When combined with use of 11C-CGP 12177, cardiac adrenergic neurotransmission can be assessed.
Classification of breathing events using load cells under the bed (2009)

Sleep disturbances are prevalent, financially taxing, and have a negative effect on health and quality of life. One of the most common sleep disturbances is obstructive sleep apnea-hypopnea syndrome (OSAHS) which frequently goes undiagnosed. The gold standard for diagnosing OSAHS is polysomnography (PSG)-a procedure that is inconvenient, time-consuming, and interferes with normal sleep patterns. We are investigating an alternative to PSG in which unobtrusive load cells fitted under the bed are used to monitor movement, heart rate, and respiration. In this paper we describe how load cell data can be used to distinguish between clinically relevant disordered breathing (apneas and hypopneas) and normal respiration. The method correctly classified disordered breathing segments with a sensitivity of 0.77 and a specificity of 0.91.
Open-cycle magnetohydrodynamic electrical power generation (1978)

A critical overview of the status of MHD technology is presented. The latest developments in the specialized fields of engineering that contribute most significantly to the development of MHD power plants are reviewed. Analyses of the technical--economic aspects of the technology are included. Separate abstracts were prepared for the 14 chapters included. (WHK)
Genomic Targeting of Methylated DNA: Influence of Methylation on Transcription, Replication, Chromatin Structure, and Histone Acetylation (2000)

We have developed a strategy to introduce in vitro-methylated DNA into defined chromosomal locations. Using this system, we examined the effects of methylation on transcription, chromatin structure, histone acetylation, and replication timing by targeting methylated and unmethylated constructs to marked genomic sites. At two sites, which support stable expression from an unmethylated enhancer-reporter construct, introduction of an in vitro-methylated but otherwise identical construct results in specific changes in transgene conformation and activity, including loss of the promoter DNase I-hypersensitive site, localized hypoacetylation of histones H3 and H4 within the reporter gene, and a block to transcriptional initiation. Insertion of methylated constructs does not alter the early replication timing of the loci and does not result in de novo methylation of flanking genomic sequences. Methylation at the promoter and gene is stable over time, as is the repression of transcription. Surprisingly, sequences within the enhancer are demethylated, the hypersensitive site forms, and the enhancer is hyperacetylated. Nevertheless, the enhancer is unable to activate the methylated and hypoacetylated reporter. Our findings suggest that CpG methylation represses transcription by interfering with RNA polymerase initiation via a mechanism that involves localized histone deacetylation. This repression is dominant over a remodeled enhancer but neither results in nor requires region-wide changes in DNA replication or chromatin structure.
Inhibition of apoptosis in human tumour cells by okadaic acid (1992)

Gamma-radiation, tetrandrine, bistratene A, and cisplatin were all found to induce pronounced morphological changes characteristic of apoptosis and extensive DNA fragmentation in the human BM13674 cell line 8 h after treatment. Apoptosis induced in BM13674 cells by these diverse agents was markedly inhibited by 1 microM okadaic acid, a tumour promoter that inhibits protein phosphatases 1 and 2A. This compound also inhibited the appearance of apoptosis in fresh human leukaemia cells that had been exposed to gamma-radiation. The inhibition of apoptosis was confirmed using fluorescence microscopy and DNA gel electrophoresis. Dephosphorylation of a limited number of proteins was shown to be associated with apoptosis and okadaic acid prevented these dephosphorylations. Previous studies on the BM13674 cell line showed that an inhibitor of protein synthesis failed to prevent apoptosis in these cells. The present data provides further support that posttranslational modification of proteins, in particular, phosphorylation/dephosphorylation status, plays an important role in inhibition/activation of programmed cell death in different human cells after exposure to several cytotoxic agents.
Recent Applications of Chiral Ferrocene Ligands in Asymmetric Catalysis (2006)

Despite the impressive progress achieved in asymmetric catalysis during the last decade, an increasing number of new catalysts, ligands, and applications are reported every year to satisfy the need to embrace a wider range of reactions and to improve the efficiency of existing processes. Because of their availability, unique stereochemical aspects, and wide variety of coordination modes and possibilities for the fine-tuning of the steric and electronic properties, ferrocene-based ligands constitute one of the most versatile ligand architectures in the current scenario of asymmetric catalysis. Over the last few years ferrocene catalysts have been successfully applied in an amazing variety of enantioselective processes. This Review documents these recent advances, with special emphasis on the most innovative asymmetric processes and the development of novel, efficient types of ferrocene ligands.
Aluminum Plasmonic Nanoantennas (2012)

The use of aluminum for plasmonic nanostructures opens up new possibilities, such as access to short-wavelength regions of the spectrum, complementary metal-oxide-semiconductor (CMOS) compatibility, and the possibility of low-cost, sustainable, mass-producible plasmonic materials. Here we examine the properties of individual Al nanorod antennas with cathodoluminescence (CL). This approach allows us to image the local density of optical states (LDOS) of Al nanorod antennas with a spatial resolution less than 20 nm and to identify the radiative modes of these nanostructures across the visible and into the UV spectral range. The results, which agree well with finite difference time domain (FDTD) simulations, lay the groundwork for precise Al plasmonic nanostructure design for a variety of applications.
Somatodendritic Depolarization-Activated Potassium Currents in Rat Neostriatal Cholinergic Interneurons Are Predominantly of the A Type and Attributable to Coexpression of Kv4.2 and Kv4.1 Subunits (1998)

Unlike other neostriatal neurons, cholinergic interneurons exhibit spontaneous, low-frequency, repetitive firing. To gain an understanding of the K+ channels regulating this behavior, acutely isolated adult rat cholinergic interneurons were studied using whole-cell voltage-clamp and single-cell reverse transcription-PCR techniques. Cholinergic interneurons were identified by the presence of choline acetyltransferase (ChAT) mRNA. Depolarization-activated potassium currents in cholinergic interneurons were dominated by a rapidly inactivating, K+-selective A current that became active at subthreshold potentials. Depolarizing prepulses inactivated this component of the current, leaving a delayed, rectifier-like current. Micromolar concentrations of Cd2+ dramatically shifted the voltage dependence of the A current without significantly affecting the delayed rectifier. The A-channel antagonist 4-aminopyridine (4-AP) produced a voltage-dependent block (IC50, approximately 1 mM) with a prominent crossover at millimolar concentrations. On the other hand, TEA preferentially blocked the sustained current component at concentrations <10 mM. Single-cell mRNA profiling of subunits known to give rise to rapidly inactivating K+ currents revealed the coexpression of Kv4.1, Kv4.2, and Kv1.4 mRNAs but low or undetectable levels of Kv4.3 and Kv3.4 mRNAs. Kv1.1, beta1, and beta2 subunit mRNAs, but not beta3, were also commonly detected. The inactivation recovery kinetics of the A-type current were found to match those of Kv4.2 and 4.1 channels and not those of Kv1.4 or Kv1. 1 and beta1 channels. Immunocytochemical analysis confirmed the presence of Kv4.2 but not Kv1.4 subunits in the somatodendritic membrane of ChAT-immunoreactive neurons. These results argue that the depolarization-activated somatodendritic K+ currents in cholinergic interneurons are dominated by Kv4.2- and Kv4. 1-containing channels. The properties of these channels are consistent with their playing a prominent role in governing the slow, repetitive discharge of interneurons seen in vivo.
Electron impact mass spectrometry of some 5‐amino salicylic acid derivatives (1994)

Abstract The electron impact‐induced fragmentation processes of eleven differently substituted 5‐amino salicylic acids were studied by means of mass‐analyzed ion kinetic energy (MIKE) spectroscopy, parent‐ion spectroscopy and accurate mass measurements. Most of the fragmentation processes are related to the cleavages of the 5‐amino substituents. Unusual behaviour is that related to the CO 2 loss from the molecular ion, quite significant in the normal electron ionization spectra and completely undetectable in the MIKE spectra.
Involvement of the neurotensin receptor subtype NTR3 in the growth effect of neurotensin on cancer cell lines (2001)

The expression of the 3 currently known neurotensin receptors was studied in human cancer cells of prostatic, colonic or pancreatic origin by means of RT-PCR analysis and binding experiments. All the cells selected for this work have been shown to exhibit a growth response to neurotensin. We found that the 7 transmembrane domain, levocabastine insensitive receptor (NTR1) is expressed in most but not all of the cells studied whereas the 7 transmembrane domain, levocabastine sensitive receptor (NTR2) is present in none of these cells. The 100 kDa-type I neurotensin receptor (NTR3) is expressed in all the cells assayed. Moreover, we demonstrated that neurotensin can stimulate the growth of CHO cells stably transfected with the NTR3. Taken together, our results strongly suggest that the NTR3 subtype could be involved in the growth response of human cancer cells to neurotensin.
Regulation of surface presentation of IcsA, a Shigella protein essential to intracellular movement and spread, is growth phase dependent (1994)

After lysing the phagocytic vacuole, Shigella spp. accumulate filaments of polymerized actin on their surface at one pole, leading to the formation of actin tails that enable them to move through the cytoplasm. We have recently demonstrated that the Shigella protein IcsA is located at the pole that is adjacent to the growing end of the actin tail (M. B. Goldberg, O. Barzu, C. Parsot, and P. J. Sansonetti, J. Bacteriol. 175:2189-2196, 1993). Not every bacterium that is observed within the cytoplasm has an actin tail. The factors that determine when a bacterium will form a tail are unknown. Here we demonstrate that at the moment of initiation of movement, Shigella spp. are frequently in the process of division. Furthermore, the expression of IcsA on the surface of the bacteria occurs in a growth phase-dependent fashion, suggesting that the surface expression of IcsA per se determines the observed association of bacterial division with movement.
Interleukin 10 protects mice from lethal endotoxemia. (1993)

Interleukin 10 (IL-10) decreases production of IL-1, IL-6, and tumor necrosis factor alpha (TNF-alpha) in vitro, and neutralization of IL-10 in mice leads to elevation of the same monokines. We test here whether this monokine-suppressing property of IL-10 confers on it the capacity to protect mice from lipopolysaccharide-induced shock, a monokine-mediated inflammatory reaction. A single injection of 0.5-1 microgram of recombinant murine IL-10 reproducibly protected BALB/c mice from a lethal intraperitoneal injection of endotoxin. This result was obtained whether the IL-10 was administered concurrently with, or 30 min after the injection of endotoxin. The protective effect of IL-10 was reversed by prior injection of neutralizing anti-IL-10 antibodies, and correlated with a substantial decrease in endotoxin-induced TNF-alpha release. These data implicate IL-10 as a candidate for treatment of bacterial sepsis, and more generally as an effective antiinflammatory reagent.
The kallikrein-kinin system as mediator in vasogenic brain edema (1986)

Evidence has previously been provided that administration of kinins to the cerebrum causes edema and opening of the blood-brain barrier. It has further been shown that these highly active compounds are formed in the brain under pathophysiological conditions. Their formation was enhanced when cerebral blood flow became compromised by an increase in intracranial pressure. Final evidence, however, was not available as to whether specific inhibition of the kallikrein-kinin (KK) system has a therapeutic function in acute head injury. The authors have demonstrated in rabbits that inhibition of the activating enzyme kallikrein by aprotinin or by aprotinin plus soybean trypsin inhibitor (SBTI), which interfere with plasma and tissue kallikrein, is associated with a decrease in formation of posttraumatic swelling after a standardized cold lesion to the brain. Saline-treated control animals with cerebral cold-induced injury had an increase in hemispheric weight 24 hours later of 13.0% +/- 0.8% (standard error of the mean) in the damaged hemisphere compared to the contralateral nondamaged hemisphere. Administration of aprotinin or aprotinin plus SBTI led to a significant reduction of hemispheric swelling of 10.1% +/- 0.7% or 10.4% +/- 0.7%, respectively. In animals receiving SBTI only, hemispheric swelling evolving from cold injury was not significantly reduced. Therapeutic reduction of brain edema by aprotinin cannot be attributed to a nonspecific effect on the blood pressure, which in the experimental groups remained almost normal as compared to the control animals. Failure of SBTI to influence posttraumatic brain swelling may have resulted from disturbances in intravascular coagulation. Measurements of aprotinin in plasma and tissue demonstrate that the inhibitor doses employed are within an effective therapeutic range. Attenuation of brain edema by specific inhibition of the KK system provides evidence for a mediator role of kinins in vasogenic edema. Clinical trials with inhibitors of the KK system in acute forms of traumatic lesions associated with vasogenic edema appear worthwhile.
Adenovirus-mediated gene transfer using in-situ perfusion of the liver graft (1997)

Abstract. To establish an efficient technique for adenovirus-mediated gene transfer in liver transplantation, we evaluated the in situ perfusion of liver grafts. The grafts were perfused in situ with 1 × 1010 of El-deleted, replication-defective adenoviral vectors encoding the LacZ gene driven by the human CMV promoter, either through the hepatic artery (group 1) or the portal vein (group 2). Group 3 animals served as negative controls; their liver grafts were perfused with lac-tated Ringer's solution through the portal vein. PCR confirmed the presence of viral DNA in every graft perfused with viral vectors. In X-gal staining, positive staining was observed almost exclusively at the portal triad in group 1, whereas in group 2 minimal staining was observed, predominantly in the parenchymal area. Protein production from the transfected gene was confirmed by a functional protein assay; the values were 0.16 %± 0.07 % liver protein in group 1,0.13 %± 0.02 % in group 2, and 0.007 %± 0.0003 % in group 3 on postoperative day 2. In conclusion, in situ perfusion of the viral vectors through the hepatic artery resulted in an effective expression of the transfected gene, predominantly at the portal triad.
Reducing cache misses using hardware and software page placement (1999)

As the gap between memory and processor speeds continues to widen, cache efficiency is an increasingly important component of processor performance. Compiler techniques have been used to improve instruction and data cache performance for virtually indexed caches by mapping code and data with temporal locality to different cache blocks. In this paper we examine the performance of compiler and hardware approaches for reordering pages in physically addressed caches to eliminate cache misses. The software approach provides a color mapping at compile-time for code and data pages, which can then be used by the operating system to guide its allocation of physical pages. The hardware approach works by adding a page remap field to the TLB, which is used to allow a page to be remapped to a different color in the physically indexed cache while keeping the same physical page in memory. The results show that software page placement provided a 28% speedup and hardware page placement provided a 21% speedup on average for a superscalar processor. For a 4 processor single-chip multiprocessor, the miss rate was reduced from 8.7% down to 7.2% on average.
Pace independent mobile gait biometrics (2015)

Accelerometers embedded in mobile devices have shown great potential for non-obtrusive gait biometrics by directly capturing a user's characteristic locomotion. Although gait analysis using these sensors has achieved highly accurate authentication and identification performance under controlled experimental settings, the robustness of such algorithms in the presence of assorted variations typical in real world scenarios remains a major challenge. In this paper, we propose a novel pace independent mobile gait biometrics algorithm that is insensitive to variability in walking speed. Our approach also exploits recent advances in invariant mobile gait representation to be independent of sensor rotation. Performance evaluations on a realistic mobile gait dataset containing 51 subjects confirm the merits of the proposed algorithm toward practical mobile gait authentication.
Mobile Augmented Reality Survey: From Where We Are to Where We Go (2017)

The boom in the capabilities and features of mobile devices, like smartphones, tablets, and wearables, combined with the ubiquitous and affordable Internet access and the advances in the areas of cooperative networking, computer vision, and mobile cloud computing transformed mobile augmented reality (MAR) from science fiction to a reality. Although mobile devices are more constrained computationalwise from traditional computers, they have a multitude of sensors that can be used to the development of more sophisticated MAR applications and can be assisted from remote servers for the execution of their intensive parts. In this paper, after introducing the reader to the basics of MAR, we present a categorization of the application fields together with some representative examples. Next, we introduce the reader to the user interface and experience in MAR applications and continue with the core system components of the MAR systems. After that, we discuss advances in tracking and registration, since their functionality is crucial to any MAR application and the network connectivity of the devices that run MAR applications together with its importance to the performance of the application. We continue with the importance of data management in MAR systems and the systems performance and sustainability, and before we conclude this survey, we present existing challenging problems.
Synthesis of 10,11-anhydroerythromycin (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 10,11-anhydroerythromycinJ. R. Hauske and G. KostekCite this: J. Org. Chem. 1982, 47, 8, 1595–1596Publication Date (Print):April 1, 1982Publication History Published online1 May 2002Published inissue 1 April 1982https://pubs.acs.org/doi/10.1021/jo00347a052https://doi.org/10.1021/jo00347a052research-articleACS PublicationsRequest reuse permissionsArticle Views69Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts