gebhart/patrepeval huggingface dataset:
Effect of 1 alpha (OH)-vitamin D3 on insulin secretion in diabetes mellitus. (1986)

Fourteen non-insulin-dependent diabetic subjects were placed on a balanced diet for 2-3 weeks followed by the same balanced diet alone (group I: control, n = 7) or daily administration of 1 alpha (OH)-vitamin D3 (1 alpha (OH)D3) (group II: 2 micrograms/day, n = 7) additionally for the next 3 weeks. A 75 g oral glucose loading test was conducted before and after the experiment and the plasma insulin response was compared along with the metabolic parameters including serum calcium, phosphorus and serum lipids. The following results were obtained. (1) Total insulin secretion in response to 75 g glucose loading was significantly increased in group II (16.3 +/- 3.9 microU/2 h/ml versus 22.7 +/- 4.9 microU/2 h/ml; P less than 0.05), though no difference was demonstrated in group I. (2) Mean serum calcium level was significantly increased from 9.4 +/- 0.1 mg/dl to 9.6 +/- 0.1 mg/dl (P less than 0.05) and serum free fatty acid level was decreased from 0.80 +/- 0.07 mEq/l to 0.53 +/- 0.07 mEq/l (P less than 0.05) in group II, but not in group I. (3) However, there was no direct correlation between total insulin secretion during a 75 g oral glucose loading test and serum calcium or free fatty acid level. The findings that 1 alpha (OH)D3 enhances insulin secretion and reduces the levels of serum free fatty acid in non-insulin-dependent diabetics provide us with the possibility that vitamin D may play some role in the regulation of insulin secretion.
Peptides corresponding to CD4-interacting regions of murine MHC class II molecules modulate immune responses of CD4+ T lymphocytes in vitro and in vivo (1996)

Immune responses mediated by CD4+ T cells depend on Ag-specific alpha beta TCRs that recognize the specific antigenic peptide presented by MHC class II molecules. Interactions between CD4 coreceptors and monomorphic regions of MHC class II molecules contribute to these responses. To examine whether immune reactions could be modulated by specifically interfering with CD4-MHC class II interactions, we have used, in various in vitro and in vivo assays, peptides that correspond to a region of MHC class II molecules previously shown to control interaction with CD4. Depending on the chemical nature and concentration of these peptides, they modulated Ag-specific responses of CD4+ T cells. At high concentrations, these peptides inhibited T cell responses in vitro. However, under conditions that can cause Ag-induced unresponsiveness, the peptides enhanced T cell responses. Also, primary in vivo immune responses to systemically administered soluble protein Ag, keyhole limpet hemocyanin, were enhanced when mice were treated with peptides corresponding to the CD4-interacting region of MHC class II molecules but not when treated with control peptides. Lymphokine profiles suggested that the peptides may favor the differentiation of Th1 cells, because lymphocytes from peptide-treated mice secreted more IL-2 and IFN-gamma than lymphocytes from nontreated or control-peptide-treated mice upon restimulation with Ag in vitro. These results demonstrate that MHC class II-derived peptides can directly interfere with interactions with CD4 and modulate T cell responses in vitro and in vivo.
The measurement of gas relative permeability for low permeability cores using a pressure transient method (1989)

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Deep-Vein Thrombosis (1994)

Credit for fundamental studies leading to our current understanding of deep-vein thrombosis should be given to Bauer, who used phlebography to diagnose deep-vein thrombosis complicating fractures of the tibia,1 and to Sevitt and Gallagher for their autopsy-based studies of the prevalence of venous thromboembolism in patients with other injuries2,3. The development of objective methods for the diagnosis of deep-vein thrombosis has facilitated the investigation of its natural history and has provided a rational basis for its prevention and treatment.DiagnosisMost venous thrombi are clinically silent when they are first detectable by objective methods,2,4 probably because they . . .
Interleukin-9 potentiates the interleukin-4-induced IgE and IgG1 release from murine B lymphocytes. (1993)

Interleukin-9 (IL-9) is a mouse T-cell-derived cytokine that supports the growth of mucosal type mast cells suggesting its role in the regulation of type I hypersensitivity reactions. Therefore the possible effect of IL-9 on the in vitro regulation of IL-4-induced IgE and IgG1 releases in the mouse was investigated. In this report, we present evidence that IL-9 potentiated IL-4-induced IgE and IgG1 releases from lipopolysaccharide (LPS)-primed murine B lymphocytes, whereas IL-9 alone was ineffective. The potentiating effect of IL-9 is specific for IgE and IgG1 since no effect on IgM production was observed. This potentiating effect was neither related to an enhanced cell viability, nor to an alteration of the IL-4-induced expression of class II antigens by murine B cells. Besides the fact that IL-9 increased the number of IgG1-secreting cells, this cytokine might also enhance immunoglobulin release on a cell basis. Taken together, these data suggest that IL-9 plays an in vitro regulatory role in antibody synthesis, probably via a direct action on murine B lymphocytes.
Rapid Validation of the Overall Structure of an Internal Domain-Swapped Mutant of the Anti-HIV Protein Cyanovirin-N Using Residual Dipolar Couplings (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTRapid Validation of the Overall Structure of an Internal Domain-Swapped Mutant of the Anti-HIV Protein Cyanovirin-N Using Residual Dipolar CouplingsCarole A. BewleyView Author Information Laboratory of Bioorganic Chemistry National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda, Maryland 20892 Cite this: J. Am. Chem. Soc. 2001, 123, 5, 1014–1015Publication Date (Web):January 10, 2001Publication History Received20 October 2000Revised5 December 2000Published online10 January 2001Published inissue 1 February 2001https://pubs.acs.org/doi/10.1021/ja005714ohttps://doi.org/10.1021/ja005714orapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views150Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Coupling reactions,Monomers,Peptides and proteins,Protein structure,X-rays Get e-Alerts
Simultaneous B-M-mode scanning method for real-time full-range Fourier domain optical coherence tomography (2006)

High-speed complex full-range Fourier domain optical coherence tomography (FD-OCT) is demonstrated. In this FD-OCT, the phase modulation of a reference beam (M scan) and transversal scanning (B scan) are simultaneously performed. The Fourier transform method is applied along the direction of the B scan to reconstruct complex spectra, and the complex spectra comprise a full-range OCT image. Because of this simultaneous B-M-mode scan, the FD-OCT requires only a single A scan for each single transversal position to obtain a full-range FD-OCT image. A simple but slow version of the FD-OCT visualizes the cross section of a plastic plate. A modified fast version of this FD-OCT investigates a sweat duct in a finger pad in vivo and visualizes it with an acquisition time of 27 ms.
[?쇰Ц] ??濡쒕젋議?援먰쉶??嫄댁텞怨?利앹텞怨꾪쉷??愿???곌뎄 (2014)

The purpose of this paper is to study on the architecture and extension project for the Church of St. Lorenzo. This study is composed of a through analysis of the extension elements on the church building and extension type for extension project of the Church of St. Lorenzo. The results of study are as follows: 1. The extension project for the Church of St. Lorenzo was basically consisted of the concept of a horizontal extension plan through both the interior and exterior space of the church building. This project was the plan of concept of additional or affixing extension through existing spaces with necessary spaces to make up for the previous simple space and form as well as functional aspect. 2. The unit spaces of the nave, the aisle, the small chapels bilaterally adorning the aisles, the transept and the chapels around transepts, and the sacristies by the extension project for the Church of St. Lorenzo is composed of regulation, balance and harmony as geometric space composition according to simple proportion system on whole and parts as well as parts and parts, through the definite articulation by each space zoning. 3. The most important innovative aspect different to previous churches in the extension project for the Church of St. Lorenzo is the compositive system of each other symmetrical spaces through long centrical axis of central part, applying the module system for horizontal arrangement. In particular, the use of regular module on repetition and proportion of rhythm from architectural composition system was precisely composed with the alter that consists of visual focus to express more accurate perspective.
Hardware Development And Initial Subassembly Tests Of A Gas-fired Stirling Engine/refrigerant Compressor Assembly (2005)

A gas-fired Stirling/Rankine heat pump is being developed at Sunpower. Inc. The free-piston Stirling engine/magnetic coupling/refrigerant compressor (FPSE/ MC/C) assembly used as the power module for this type of heat pump is currently in the test phase. To achieve high efficiency, low cost, and a more durable system, modifications have been made to a previously introduced design. The modifications include changes in material selection, a different displacer drive, and the use of a low-cost and more efficient engine cooler. A commercially available R-22 compressor is employed in the prototype. Low cost iron-neodymium permanent magnets are used to provide an efficient magnetic coupling. To match the engine power to the lead, a double-acting variable gas spring is arranged in parallel with the engine and compressor. After the gas spring was designed and fabricated, it was tested with the compressor. Before system integration and tests, the engine/linear alternator and the compressorlheat pump have been set up and are being tested separately
The SLP-76 Src Homology 2 Domain Is Required for T Cell Development and Activation (2011)

The adapter protein Src homology 2 (SH2) domain-containing leukocyte protein of 76 kDa (SLP-76) is critical for multiple aspects of T cell development and function. Through its protein-binding domains, SLP-76 serves as a platform for the assembly of multiple enzymes and adapter proteins that function together to activate second messengers required for TCR signal propagation. The N terminus of SLP-76, which contains three tyrosines that serve as docking sites for SH2 domain-containing proteins, and the central proline-rich region of SLP-76 have been well studied and are known to be important for both thymocyte selection and activation of peripheral T cells. Less is known about the function of the C-terminal SH2 domain of SLP-76. This region inducibly associates with ADAP and HPK1. Combining regulated deletion of endogenous SLP-76 with transgenic expression of a SLP-76 SH2 domain mutant, we demonstrate that the SLP-76 SH2 domain is required for peripheral T cell activation and positive selection of thymocytes, a function not previously attributed to this region. This domain is also important for T cell proliferation, IL-2 production, and phosphorylation of protein kinase D and IκB. ADAP-deficient T cells display similar, but in some cases less severe, defects despite phosphorylation of a negative regulatory site on SLP-76 by HPK1, a function that is lost in SLP-76 SH2 domain mutant T cells.
Interactions between bone and hydroxyapatite filled 4 META/MMA-TBB adhesive cement in vitro and in physiological environment (2002)

These studies examined the effects of hydroxyapatite (HA) filled PMMA-4 META cement in bone. The cement's liquid portion was of 4-methacryloyloxyethyl trimellitate anhydride (4-META), methyl methacrylate (MMA) monomer, and initiator tri-n-butyl borane (TBB). Powder was of 50 wt.% polymethyl methacrylate (PMMA) and 50 wt.% porous HA particles. In vitro study showed the tensile bond strength was reversibly proportional to HA filler content and size. All specimens were evaluated using light microscopy and scanning electron microscopy (SEM). In vivo study of 4 dogs for 4 and 12 weeks showed HA filled PMMA-4 META cement stabilizes the cement-bone interface. All microscopic examinations showed not only exposed HA particles at the surface of the apatite filled resin cement but demonstrated areas of direct bone apposition with no fibrous tissue, also in the resin portion. This reinforces the importance in inducing bone apposition and thus contributing to the overall implant-cement stability.
Prevention of immune dysfunction and vitamin E loss by dehydroepiandrosterone and melatonin supplementation during murine retrovirus infection (1999)

Female C57BL/6 mice infected with the LP-BM5 leukaemia retrovirus developed murine acquired immune-deficiency syndrome (AIDS). Dehydroepiandrosterone (DHEA) and melatonin (MLT) modify immune dysfunction and prevent lipid peroxidation. We investigated whether DHEA and MLT could prevent immune dysfunction, excessive lipid peroxidation, and tissue vitamin E loss induced by retrovirus infection. Retrovirus infection inhibited the release of T helper 1 (Th1) cytokines, stimulated secretion of Th2 cytokines, increased hepatic lipid peroxidation, and induced vitamin E deficiency. Treatment with DHEA or MLT alone, as well as together, largely prevented the reduction of B- and T-cell proliferation as well as of Th1 cytokine secretion caused by retrovirus infection. Supplementation also suppressed the elevated production of Th2 cytokines stimulated by retrovirus infection. DHEA and MLT simultaneously reduced hepatic lipid peroxidation and prevented vitamin E loss. The use of DHEA plus MLT was more effective in preventing retrovirus-induced immune dysfunction than either DHEA or MLT alone. These results suggest that supplementation with DHEA and MLT may prevent cytokine dysregulation, lipid oxidation and tissue vitamin E loss induced by retrovirus infection. Similarly, hormone supplementation also modified immune function and increased tissue vitamin E levels in uninfected mice.
Syringe loading introduces macromolecules into living mammalian cell cytosol (1992)

We describe a simple, efficient, gentle and inexpensive technique for the introduction of normally impermeant macromolecules into the cytosol of living mammalian cells growing in suspension or attached to the culturing substratum. Loading is achieved by the production of transient, survivable plasma membrane disruptions as cells are passed back and forth through a standard syringe needle or similar narrow orifice. The loading volume required, which contains cells and the macromolecule to be loaded, can be as little as 5 microliters, thus minimizing the use of valuable reagents. In addition, we report that the surfactant molecule, Pluronic F-68, is capable of altering the physical properties of the plasma membrane in such a way as to increase loading efficiency and the long-term survivability of cells loaded by this and other mechanically based cell-loading techniques.
Phase II/III Trial of Etoposide and High-Dose Ifosfamide in Newly Diagnosed Metastatic Osteosarcoma: A Pediatric Oncology Group Trial (2002)

PURPOSE: The objectives of this trial were to estimate the response rate, progression-free survival, and overall survival of patients who received therapy with etoposide and high-dose ifosfamide, and to define the toxicity of this combination when provided with standard chemotherapy in patients with newly diagnosed metastatic osteosarcoma. PATIENTS AND METHODS: Eligible patients received infusions of 100 mg/m 2 per day of etoposide and 3.5 g/m 2 per day of ifosfamide for 5 days. Therapy with granulocyte colony-stimulating factor was begun on day 6. This was repeated 3 weeks after therapy was begun. Response was determined at week 6 by both standard World Health Organization response criteria and by pathologic determination of tumor necrosis of the primary tumor. RESULTS: Forty-three patients were registered; 39 were assessable for response and 41 for toxicity and survival. Twenty-eight (68%) of 41 had metastatic sites only in the lung; 12 (29%) had metastatic sites in other bones with or without lung involvement. Four patients (10%) experienced complete response, and 19 patients (49%) experienced partial response, for an overall response rate of 59% ± 8%. The projected 2-year progression-free survival (PFS) for the 28 patients with metastases to lungs was 39% ± 11%. The projected 2-year PFS for the 12 patients with metastases to other bones (with or without pulmonary metastases) was 58% ± 17%. Two patients died as a result of therapy toxicity. Eighty-three percent of patients had grade 4 neutropenia, and 29% had grade 4 thrombocytopenia. Ten patients (24%) had sepsis. Fanconi’s syndrome was observed in five patients. CONCLUSION: The combination of etoposide and high-dose ifosfamide is effective induction chemotherapy for patients with metastatic osteosarcoma, despite significant associated myelosuppression sometimes complicated by infection and renal toxicity.
A MEMS Radio-Frequency Ion Mobility Spectrometer for Chemical Agent Detection (2000)

A first-of-a-kind MEMS Radio-Frequency Ion Mobility Spectrometer (RF-IMS) with a miniature drift tube (0.6 cm3) has been fabricated and tested. The spectrometer has detection limits in the parts-per-billion and the ability to identify chemicals not resolved in conventional time-of-flight ion mobility spectrometry. Spectrometer operation with a miniature 10.6eV (X=116.5 nm) UV photo-discharge lamp and a 100 pCi radioactive ionization source has been demonstrated. The RF-IMS has been interfaced to a mass spectrometer and RF-IMS spectral peaks have been confirmed. The RF-IMS/MS configuration illustrates another use for the RF-IMS as a pre-filter for atmospheric pressure chemical ionization mass spectrometry applications. mobility of an ion is field dependent and can change significantly as the field strength increases. Different ion species will have particular mobility dependencies on electric field, see Fig. The RF-IMS utilizes the change in mobility between the high field and low field conditions to identify the different ion species.
Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs (2000)

Canine hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis (RCND) is a rare, naturally occurring inherited cancer syndrome observed in dogs. Genetic linkage analysis of an RCND-informative pedigree has identified a linkage group flanking RCND (CHP14-C05.377-C05.414-FH2383-C05. 771-[RCND-CPH18]-C02608-GLUT4-TP53-ZuBe Ca6-AHT141-FH2140-FH2594) thus localizing the disease to a small region of canine chromosome 5. The closest marker, C02608, is linked to RCND with a recombination fraction (theta) of 0.016, supported by a logarithm of odds score of 16.7. C02608 and the adjacent linked markers map to a region of the canine genome corresponding to portions of human chromosomes 1p and 17p. A combination of linkage analysis and direct sequencing eliminate several likely candidate genes, including tuberous sclerosis 1 and 2 genes (TSC1 and TSC2) and the tumor suppressor gene TP53. These data suggest that RCND may be caused by a previously unidentified tumor suppressor gene and highlight the potential for canine genetics in the study of human disease predisposition.
Privacy of the long-term identities in cellular networks (2016)

Identity and location privacy are of particular interest for mobile devices because people typically carry their mobile phone all the time and they also use the same device for a long time. Attacks by IMSI catchers have been reported in many countries. Cellular systems have had protection against passive attackers since GSM: identity confidentiality is provided by use of temporary identities that are delivered from the network to the mobile device over encrypted signalling channel. We discuss the reasons why protection against active attackers, e.g. IMSI catchers, is not provided in 3G or 4G networks. In 5G networks, the number of different kinds of heterogeneous network operators could increase, and we explain that some of these may become active or passive attackers against identity and location privacy. We show that typical protection mechanisms that have been proposed against active attackers who are outsiders would not work against these insider attackers. Then, we discuss further protection mechanisms against insider attackers and conclude that these would become too heavy for large-scale consumer networks like 5G.
Induction of gene expression by exon 2 of the major E1A proteins of adenovirus type 5 (1993)

We have constructed an adenovirus type 5 (Ad5) E1A mutant, dl1119/520, that produces essentially only exon 2 of the major E1A proteins. In infected primary baby rat kidney cells, this mutant induced expression of the E1B 55-kDa protein, and in infected human KB cells, it induced expression of this protein, the E2A 72-kDa protein, and hexon. In KB cells, this mutant grew substantially better than Ad5 dl312, which lacks E1A, and as well as Ad5 dl520, an E1A mutant producing only the 243-residue protein. These results suggest that exon 2 of E1A proteins on its own was able to activate gene expression. We also constructed mutants of dl1119/520, containing small deletions in regions of exon 2 that others found to be associated with effects on the properties of E1A transformants. None of these deletions destroyed gene activation completely, indicating that there may be some redundancy among sequences in exon 2 for inducing gene expression. The two deletions that decreased induction the most, residues 224 to 238 and 255 to 270, were in regions reported to be associated with the expression of a metalloprotease and with enhanced transformation, suggesting that exon 2 may regulate expression of genes governing cell growth. It is remarkable that all sections of E1A proteins, exon 1, the unique region, and exon 2, have now been found to affect gene expression.
BISTABLE SWITCHING IN NIOBIUM OXIDE DIODES (1965)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation W. R. Hiatt, T. W. Hickmott; BISTABLE SWITCHING IN NIOBIUM OXIDE DIODES. Appl. Phys. Lett. 15 March 1965; 6 (6): 106–108. https://doi.org/10.1063/1.1754187 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search