gebhart/patrepeval huggingface dataset:
Variable Pore Size, Variable Chemical Functionality, and an Example of Reactivity within Porous Phenylacetylene Silver Salts (1999)

Investigations on molecular variants of the 3-fold symmetric 1,3,5-tris(4-ethynylbenzonitrile)benzene crystallized with silver triflate revealed a nearly invariant pseudohexagonal porous structure type. Modifications involved the attachment of pendant groups to the central aromatic ring of the parent molecule. Pendant groups include the vinyl group, stilbene, the chiral group myrtanol, and groups with different chemical functionalities such as alcohols, ethers, and esters. Modifications also included the addition of elongated spacer units between the central benzene ring and the peripheral nitrile groups. In these molecules the acetylene bridges of 1,3,5-tris(4-ethynylbenzonitrile)benzene were replaced with diacetylene, ethynylbenzene, and diethynylbenzene type units. Single-crystal refinements for pentoxy-2,4,6-tris(4-ethynylbenzonitrile)benzene·AgOTf and 1,3,5-tris(4-(4-ethynylbenzonitrile)phenyl)benzene·AgOTf as well as powder data on 12 crystalline phases showed the consistent formation of pseudohexagonal channels, demonstrating that the parent porous architecture is stable both to functional modification of the interior of the channel as well as to enlargement of the pores. Pentoxy-2,4,6-tris(4-ethynylbenzonitrile)benzene·AgOTf refined in the monoclinic space group Am. 1,3,5-Tris(4-(4-ethynylbenzonitrile)phenyl)benzene·AgOTf was found to be triclinic with space group P1̄. These crystals have pseudohexagonal channels respectively 15 and 25 Å in diameter. Cell constants based on powder data are compatible with channel diameters ranging from 10 to 30 Å. The latter channel diameters are among the largest known for organic porous solids. The introduction of the chiral myrtanol unit led to the preparation of a chiral porous solid. The thermal and chemical stabilities of these phases were investigated. The pseudohexagonal structure proved stable to complete solvent loss from the channel. It was found in the case of a host with alcohol functionality that an acid anhydride guest, trifluoroacetic anhydride, reacted with the host to form an ester with retention of the porous structure type.
Improved response-time analysis calculations (2002)

Schedulability analysis of fixed priority preemptive scheduled systems can be performed by calculating the worst-case response-time of the involved processes. The system is deemed schedulable if the calculated response-time for each process is less than its corresponding deadline. It is desirable that the Response-Time Analysis (RTA) can be efficiently performed. This is particularly important in dynamic real-time systems when a fast response is needed to decide whether a new job can be accommodated, or when the RTA is extensively applied, e.g., when used to guide the heuristics in a higher level optimiser. This paper presents a set of methods to improve the efficiency of RTA calculations. The methods are proved correct, in the sense that they give the same results as traditional (non-improved) RTA. We also present an evaluation of the improvements, by applying them to the particularly time-consuming traffic model used in RTA for ATM communication networks. Our evaluation shows that the proposed methods can give an order of magnitude reduction of the execution time of RTA.
Optical properties of potassium clusters incorporated into zeolite LTA (1993)

Optical properties are reported for cationic K clusters incorporated into the \ensuremath{\alpha} cage of K-form LTA. The \ensuremath{\alpha} cage has an inside diameter of \ensuremath{\sim}11 \AA{} and is arrayed in a simple cubic structure. The loading density of potassium is systematically changed from dilute to saturated conditions. The average number of guest K atoms is 7.3 per \ensuremath{\alpha} cage at the saturation density. Three groups of absorption and/or reflection bands appear depending on the K loading density. A band at \ensuremath{\sim}2 eV increases and becomes the strongest reflection band with increasing K density, and is assigned to the surface-plasmon-like state of the K cluster. Other groups of bands are relatively weak and are interpreted in terms of the model of the transition between energy bands which originate from 1s, 1p, and 1d molecular orbitals of the K cluster. A Drude-like contribution is found in the analysis of reflection spectra. This is reminiscent of the metallic state of arrayed clusters.
Fluorescence Resonance Energy Transfer Imaging Reveals that Chemokine-Binding Modulates Heterodimers of CXCR4 and CCR5 Receptors (2008)

Taken together, our data suggest a model in which CXCR4 and CCR5 spontaneously form heterodimers and ligand-binding to CXCR4 or CCR5 causes different conformational changes affecting heterodimerization, indicating the complexity of regulation of dimerization/function of these chemokine receptors by ligand binding.
Joint torque measurement of a direct-drive arm (1984)

The design and analysis of joint torque sensors for a direct-drive arm is presented. The direct-drive arm is driven by high torque motors without reducers or other transmission. It can serve as a suitable device for implementing torque control schemes. The direct coupling of motors to their loads reduces friction, eliminates backlash and increases mechanical stiffness. All these are desirable features for precision torque control. The drive system, however, still has some errors due to electric and electromagnetic nonlinearities at the motors and amplifiers. The direct measurement of torque is therefore necessary in order to compensate for these errors. First, two different types of torque measurement are described and compared; an indirect method via current measurement and a direct method using strain gages. Next, the strain gage torque sensor is analyzed. A design principle is developed in order to achieve high sensitivity torque measurement without sacrificing the high mechanical stiffness or degrading the dynamic performance of the drive system. Implementation and experiments are described for verifying the design principle and for evaluating the sensors.
Catalytic chemical vapor deposition method to prepare high quality hydro-fluorinated amorphous silicon (1988)

A new type of chemical vapor deposition method, named ‘‘Catalytic-CVD’’ method, is presented. In the method, deposition gases are decomposed by catalytic or pyrolytic reaction between deposition gases and a heated catalyzer, and films are thermally grown on a substrate at temperatures lower than 300 °C without any help from glow discharge plasma. Hydro-fluorinated amorphous silicon (a-Si:F:H) films are deposited by this method using both a SiF2 and H2 gas mixture and a SiH2F2 and H2 mixture. It is found that a very high quality a-Si:F:H film can be obtained, and for instance, that the photosensitivity for AM-1 of 100 mW/cm2 exceeds 106 and the spin density is as low as 6×1015 cm−3.
New molecular pathways in angiogenesis (2003)

Angiogenesis has developed into a major area of cancer research. Recently, several newly identified signalling pathways have been shown to play a role in both normal and pathological (including tumour) angiogenesis. Several of the molecules involved in these pathways have potential as novel anti-cancer therapeutic targets including members of the ephrin/Eph receptor, Notch/delta, sprouty, hedgehog and roundabout/slit families. These developments are reviewed.
Expression of Programmed Cell Death Ligand in Cutaneous Squamous Cell Carcinoma and Treatment of Locally Advanced Disease With Pembrolizumab (2017)

The favorable treatment response combined with significant involvement of PD-1 and PD ligands in cSCC lesions suggests that PD-1 blockade may be a viable therapeutic option for locally advanced cSCC and provides rationale for further investigation in future clinical trials.
Oncolytic viruses as therapeutic cancer vaccines (2013)

Oncolytic viruses (OVs) are tumor-selective, multi-mechanistic antitumor agents. They kill infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells via tumor vasculature targeting and bystander effect. Multimodal immunogenic cell death (ICD) together with autophagy often induced by OVs not only presents potent danger signals to dendritic cells but also efficiently cross-present tumor-associated antigens from cancer cells to dendritic cells to T cells to induce adaptive antitumor immunity. With this favorable immune backdrop, genetic engineering of OVs and rational combinations further potentiate OVs as cancer vaccines. OVs armed with GM-CSF (such as T-VEC and Pexa-Vec) or other immunostimulatory genes, induce potent anti-tumor immunity in both animal models and human patients. Combination with other immunotherapy regimens improve overall therapeutic efficacy. Coadministration with a HDAC inhibitor inhibits innate immunity transiently to promote infection and spread of OVs, and significantly enhances anti-tumor immunity and improves the therapeutic index. Local administration or OV mediated-expression of ligands for Toll-like receptors can rescue the function of tumor-infiltrating CD8+ T cells inhibited by the immunosuppressive tumor microenvironment and thus enhances the antitumor effect. Combination with cyclophosphamide further induces ICD, depletes Treg, and thus potentiates antitumor immunity. In summary, OVs properly armed or in rational combinations are potent therapeutic cancer vaccines.
청소년의 기업가정신이 창업의지에 미치는 영향: 학업성적의 조절효과를 중심으로 (2016)

본 연구는 청소년의 기업가정신(위험감수성, 혁신성, 진취성)이 창업의지에 미치는 영향을 학업성적의 조절효과를 중심으로 실증분석하고 있다. 순천고등학교 3학년에 재학 중인 251명의 학생들을 대상으로 실증분석을 실시한 결과는 다음과 같다. 첫째, 청소년의 기업가정신 즉, 위험감수성, 혁신성, 진취성은 모두 창업의...
Hereditary hyperferritinemia-cataract syndrome caused by a 29-base pair deletion in the iron responsive element of ferritin L-subunit gene. (1997)

Iron availability regulates ferritin synthesis posttranscriptionally by the interaction between iron-regulatory proteins (IRPs) and an iron responsive element (IRE), a stem-loop sequence located on the 5' untranslated region of ferritin mRNA. IRPs recognize IREs as a sequence/structure motif, blocking ferritin translation. Recently, we and others independently described families with a combination of hyperferritinemia (serum L-ferritin > or = 1,000 microg/L, without iron overload) and congenital bilateral cataract, transmitted as an autosomal-dominant trait. The molecular basis were two distinct point mutations in the highly conserved CAGUG(X) hexaloop of L-ferritin IRE on chromosome 19. A new three-generation family with a similar phenotype and a unique genotype is here reported. DNA amplification by polymerase chain reaction and sequence analysis showed a 29-base pair deletion in the L-ferritin IRE, involving the whole 5' sequence essential to the base pairing of the IRE stem. This deletion is predicted to cause the disruption of IRE stem-loop secondary structure and the nearly complete abolition of the negative control of ferritin synthesis by IRE/IRP binding. Hereditary Hyperferritinemia-Cataract Syndrome (HHCS) appears as a new genetic disorder with a unique phenotype associated with at least four different mutations in the L-ferritin IRE. Hematologists should take into account HHCS in the differential diagnosis of unexplained hyperferritinemia.
Biological, Chemical, and Electronic Applications of Nanofibers (2012)

Abstract With their high‐surface‐to‐volume ratio, nanofibers have been postulated to increase interactions between nanofibrous materials and targeted substrates, which are helpful to overcome many obstacles and enhance the efficiency in a diverse number of applications. Over the past decade, many studies have been published on the fabrication of nanofibers and their applications in various fields. In this review, novel biological, chemical, and electrical characteristics of nanofibers as well as their recent status and achievements in medicine, chemistry, and electronics are analyzed. It is found that nanofibers can induce fast regeneration of many tissues/organs in medical applications and improve the efficiency of many chemical and electronics applications. magnified image
Applications of the integrated waveguide grating router (1994)

Discretely tunable filter, receiver, and laser devices based on the integration of wavelength router/multiplexers with active elements are proposed. Each of these functions has been demonstrated experimentally in integrated form in InGaAsP, and will be published elsewhere. Such devices are key elements in WDM networks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Canonical correlation analysis and local fisher discriminant analysis based multi-view acoustic feature reduction for physical load prediction (2014)

In this study we present our system for INTERSPEECH 2014 Computational Paralinguistics Challenge (ComParE 2014), Physical Load Sub-challenge (PLS). Our contribution is twofold. First, we propose using Low Level Descriptor (LLD) information as hints, so as to partition the feature space into meaningful subsets called views. We also show the virtue of commonly employed feature projections, such as Canonical Correlation Analysis (CCA) and Local Fisher Discriminant Analysis (LFDA) as ranking feature selectors. Results indicate the superiority of multi-view feature reduction approach to its single-view counterpart. Moreover, the discriminative projection matrices are observed to provide valuable information for feature selection, which generalize better than the projection itself. In our preliminary experiments we reached 75.35% Unweighted Average Recall (UAR) on PLS test set, using CCA based multi-view feature selection. Index Terms: ComParE 2014, acoustic feature selection, Canonical Correlation Analysis, Local Discriminant Analysis, Physical Load
Spin Electronics (2007)

Conventional electronics has in the past ignored the spin on the electron, however things began to change in 1988 with the discovery of giant magnetoresistance in metallic thin film stacks which led to the development of a new research area, so called spin-electronics. In the last 10 years, spin-electronics has achieved a number of breakthroughs from the point of view of both basic science and application. Materials research has led to several major discoveries:
Chemoselective High-Throughput Purification Mediated by Solid-Supported Reagents Its Application to the First 6,9-Disubstituted Purine Library Synthesis (2000)

A new application of solid-supported reagents was developed to separate the alkylated N7/N9 regioisomers derived from commercially available 2-amino-6-chloropurine. Simple filtration through an alumina/H+ pad or scavenging by AG/Dowex-50W-X8 resin provides diverse N9 regioisomers selectively in moderate yields with high purities (>90%). This purification method can be conveniently used in a high-throughput format and facilitates the synthesis of a purine library without laborious regioisomer separation and aqueous work-up. The first library synthesis of 6,9-disubstituted purines is reported using the combination of this novel separation method in conjunction with polymer-supported reagents.
Divergent Transcriptional Control of Multidrug Resistance Genes in Saccharomyces cerevisiae (1998)

Improper control of expression of ATP binding cassette transporter-encoding genes is an important contributor to acquisition of multidrug resistance in human tumor cells. In this study, we have analyzed the function of the promoter region of the Saccharomyces cerevisiae YOR1 gene, which encodes an ATP binding cassette transporter protein that is required for multidrug tolerance in S. cerevisiae. Deletion analysis of a YOR1-lacZ fusion gene defines three important transcriptional regulatory elements. Two of these elements serve to positively regulate expression of YOR1, and the third element is a negative regulatory site. One positive element corresponds to a Pdr1p/Pdr3p response element, a site required for transcriptional control by the homologous zinc finger transcription factors Pdr1p and Pdr3p in other promoters. The second positive element is located between nucleotides -535 and -299 and is referred to as UASYOR1 (where UAS is upstream activation sequence). Interestingly, function of UASYOR1 is inhibited by the downstream negative regulatory site. Promoter fusions constructed between UASYOR1 and the PDR5 promoter, another gene under Pdr1p/Pdr3p control, are active, whereas analogous promoter fusions constructed with the CYC1 promoter are not. This suggests the possibility that UASYOR1 has promoter-specific sequence requirements that are satisfied by another Pdr1p/Pdr3p-regulated gene but not by a heterologous promoter.
Thieno[2,3-c]pyrroles: synthesis, Diels-Alder reaction, and synthetic utility (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThieno[2,3-c]pyrroles: synthesis, Diels-Alder reaction, and synthetic utilityChin Kang Sha and Chiu Peng TsouCite this: J. Org. Chem. 1990, 55, 8, 2446–2450Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/jo00295a038https://doi.org/10.1021/jo00295a038research-articleACS PublicationsRequest reuse permissionsArticle Views510Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Cerium(IV) Trifluoromethanesulfonate as a Strong Oxidizing Agent (1990)

Abstract Cerium(IV) trifluoromethanesulfonate was prepared by the reaction of cerium(IV) carbonate with trifluoromethanesulfonic acid. The powerful oxidizing ability of this compound is observed in the oxidation of benzyl alcohols and alkylbenzenes.
Engraftment of Tonsillar Mononuclear Cells in Human Skin/SCID Mouse Chimera —Validation of a Novel Xenogeneic Transplantation Model for Autoimmune Diseases— (2001)

Pustulosis palmaris et plantaris (PPP) has been considered as one of the typical tonsillar focal infections, based on the marked clinical improvement of the skin lesions after tonsillectomy. Despite the accumulation of data showing the clinical efficacy of tonsillectomy for this skin lesion, fundamental etiological and pathophysiological issues have yet to be addressed. One primary obstacle hindering investigators has been the lack of an appropriate animal model for this human skin disorder. In the early stage of PPP, it has been reported that lymphocytes, predominantly CD4+ T lymphocytes, infiltrate the palmar and plantar skins. However, the origin and mechanism of infiltration by these lymphocytes is not clear and there are very few reports on whether tonsillar mononuclear cells react directly with the skin. We have been intrigued by the ability to engraft human cells onto severe combined immunodeficiency (SCID) mice, together with the opportunity for long-term graft survival and ability to adoptively transfer various human immunocompetent cells. In this review, we addressed the existing deficiencies in our understanding of the relationship between tonsils and PPP by using emerging transplantation technology involving SCID mice.
A型肉毒素对家兔股二头肌致萎缩作用的实验观察 (2014)

目的  观察A型肉毒素对家兔股二头肌的致萎缩作用。方法  以新西兰大耳白兔为实验对象，分别以大(6.0U)、中（3.0U）、小(1.0U) 3种剂量的A型肉毒素注射于一侧股二头肌，以另侧股二头肌注射同剂量生理盐水为对照，观察其致萎作用的效果及持续时间，并在显微镜下观察股二头肌的形态学变化。结果  家兔股二头肌局部注射A型肉毒素14d后，可观察到明显的肌肉萎缩，28d后肌肉萎缩稳定，且以6.0U剂量组效果最佳。形态学观察显示：单个肌纤维直径变小，肌纤维融合，边界不清晰，排列不规则，粗纤维/细纤维比值变小；肌束间间隙增宽，数量增加；细胞核增多、聚集，核与核之间距离缩小。结论  局部肌肉注射A型肉毒素致萎效果好，模型稳定，是一种较为理想的单个目的肌肌萎缩造模方法。
Cerebrospinal fluid tau protein as a biochemical marker for Alzheimer's disease: a community based follow up study (1998)

The findings confirm the high sensitivity of CSF-tau for the diagnosis of Alzheimer's disease, but high CSF-tau was also found in vascular dementia, resulting in a lower specificity. However, high CSF-tau is preferentially found in patients with vascular dementia without progressive leukoaraiosis, which may constitute a group with concomitant Alzheimer's disease pathology. High CSF-tau may be present during the whole course of the disease in Alzheimer's disease. Possibly, therefore, the same high CSF-tau concentrations may be present before the onset of clinical dementia. Follow up studies on such patients will tell whether analysis of CSF-tau is useful as a biochemical marker for early Alzheimer's disease.
Structural Complexity in Metal–Organic Frameworks: Simultaneous Modification of Open Metal Sites and Hierarchical Porosity by Systematic Doping with Defective Linkers (2014)

A series of defect-engineered metal-organic frameworks (DEMOFs) derived from parent microporous MOFs was obtained by systematic doping with defective linkers during synthesis, leading to the simultaneous and controllable modification of coordinatively unsaturated metal sites (CUS) and introduction of functionalized mesopores. These materials were investigated via temperature-dependent adsorption/desorption of CO monitored by FTIR spectroscopy under ultra-high-vacuum conditions. Accurate structural models for the generated point defects at CUS were deduced by matching experimental data with theoretical simulation. The results reveal multivariate diversity of electronic and steric properties at CUS, demonstrating the MOF defect structure modulation at two length scales in a single step to overcome restricted active site specificity and confined coordination space at CUS. Moreover, the DEMOFs exhibit promising modified physical properties, including band gap, magnetism, and porosity, with hierarchical micro/mesopore structures correlated with the nature and the degree of defective linker incorporation into the framework.
Investigating peptide sequence variations for ‘double-click’ stapled p53 peptides (2014)

Stapling peptides for inhibiting the p53/MDM2 interaction is a promising strategy for developing anti-cancer therapeutic leads. We evaluate double-click stapled peptides formed from p53-based diazidopeptides with different staple positions and azido amino acid side-chain lengths, determining the impact of these variations on MDM2 binding and cellular activity. We also demonstrate a K24R mutation, necessary for cellular activity in hydrocarbon-stapled p53 peptides, is not required for analogous 'double-click' peptides.