gebhart/patrepeval huggingface dataset:
Synthesis and Characterization of Carboxylate−FeOOH Nanoparticles (Ferroxanes) and Ferroxane-Derived Ceramics (2002)

A new environmentally benign process for producing Fe-based ceramics of variable properties is presented. We have demonstrated that the reaction between lepidocrocite and acetic acid (=AA) in water results in the formation of carboxylate−FeOOH nanoparticles called ferroxane−AA analogous to aluminum-based alumoxanes. The structure of the ferroxane particles consists of an FeOOH core part with the structure of the lepidocrocite (γ-FeOOH), coated with AA. FTIR and EXAFS at the Fe K edge indicates that AA is chemically adsorbed onto the FeOOH core part. The size of these ferroxanes is 0.3 μm composed of nanodomains of 20−30 Å with a γ-FeOOH structure. Thermolysis of the ferroxane−AA yields Fe oxide ceramics. The specific surface area of 134 m2/g does not increase from the initial mineral to the ferroxane while the pore size distribution becomes monodisperse and the diameter of the pore size decreases from 55 to 12 and 13 nm after the firing of the ferroxanes. Moreover, the ferroxane−AA has been successfully doped with metal to form a precursor for Fe mixed-metal oxides. Upon thermolysis the products evolve to homogeneous Fe−metal oxides. A low firing temperature for conversion to ceramic as well as the use of environmentally benign feedstock suggest that the process for creating ferroxane-derived ceramics should have minimal environmental impacts.
Routes to Functional Vesicle Membranes without Proteins (1984)

Abstract Fixation of reaction partners at appropriate distances from one another is a structural prerequisite for vectorial reactions and reaction sequences. In biological systems (e.g. the photosynthetically active thylakoid membrane or membrane receptors) the positions of the reaction centers are fixed by membrane‐protein complexes, but little is known about the structure of these complexes. Ordered reactive systems in synthetic vesicle membranes were first obtained by employing amphiphiles with reactive head groups as building units, by regioselective incorporation of foreign molecules into the membrane, by alignment of bolaamphiphiles with two head groups of differing solubility or size, and by the formation of domains. Chiral superstructures have also been observed in membranes, and the first stereoselective reactions have been performed in vesicle membranes. The report concludes with a brief discussion of membranes constructed from non‐amphiphilic building blocks and problems which still have to be solved.
An IQ-modulator based heterodyne 77-GHz FMCW colocated MIMO radar system (2012)

In this work the realization of a 77-GHz frequency-division multiple-access-based frequency-modulated continuous-wave multiple-input multiple-output radar with four transceiver channels in conjunction with a non-uniform linear antenna array is presented. The radar system, consisting of an RF-frontend utilizes transceiver chips with integrated inphase/quadrature-modulators to generate the frequency shifted transmit signals and a field programmable gate array-based baseband board, is used for test measurements to verify the system performance and to demonstrate the beamforming capability as well as the accuracy of the digital-beamforming method.
Red Blood Cell Precursor Mass as an Independent Determinant of Serum Erythropoietin Level (1998)

Serum erythropoietin (sEpo) concentration is primarily related to the rate of renal production and, under the stimulus of hypoxia, increases exponentially as hemoglobin (Hb) decreases. Additional factors, however, appear to influence sEpo, and in this work, we performed studies to evaluate the role of the red blood cell precursor mass. We first compared the relationship of sEpo with Hb in patients with low versus high erythroid activity. The first group included 27 patients with erythroid aplasia or hypoplasia having serum transferrin receptor (sTfR) levels < 3 mg/L (erythroid activity < 0.6 times normal), while the second one included 28 patients with beta-thalassemia intermedia having sTfR levels > 10 mg/L (erythroid activity > 2 times normal). There was no difference between the two groups with respect to Hb (8.3 +/- 1.6 v 8.0 +/- 1.3 g/dL, P > .05), but sEpo levels were notably higher in patients with low erythroid activity (1,601 +/- 1,542 v 235 +/- 143 mU/mL, P < . 001). In fact, multivariate analysis of variance (ANOVA) showed that, at any given Hb level, sEpo was higher in patients with low erythroid activity (P < .0001). Twenty patients undergoing allogeneic or autologous bone marrow transplantation (BMT) were then investigated. A marked increase in sEpo was seen in all cases at the time of marrow aplasia, disproportionately high when compared with the small decrease in Hb level. Sequential studies were also performed in five patients with iron deficiency anemia undergoing intravenous (IV) iron therapy. Within 24 to 72 hours after starting iron treatment, marked decreases in sEpo (up to one log magnitude) were found before any change in Hb level. Similar observations were made in patients with megaloblastic anemia and in a case of pure red blood cell aplasia. These findings point to an inverse relationship between red blood cell precursor mass and sEpo: at any given Hb level, the higher the number of red blood cell precursors, the lower the sEpo concentration. The most likely explanation for this is that sEpo levels are regulated not only by the rate of renal production, but also by the rate of utilization by erythroid cells.
Artificial Oxygen Carriers as Red Blood Cell Substitutes: A Selected Review and Current Status (2004)

Two distinct approaches are being explored in red blood cell substitute (RCS) development: hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbon-based oxygen carriers (PFBOCs). HBOCs are based on intra- and/or intermolecularly "engineered" human or animal hemoglobins (Hbs), optimized for O2 delivery and longer intravascular circulation. Some are currently being evaluated in Phase II/III clinical studies. PFBOCs are aqueous emulsions of perfluorocarbon derivatives that dissolve relatively large amounts of O2. A PFBOC based on a 60% (wt/vol) emulsion of perfluorooctyl bromide has been evaluated in Phase II/III clinical trials. Although current PFBOC products generally require patients to breathe O2 enriched air, they render certain advantages since they are totally synthetic. This article provides a short review of the basic principles, approaches, and current status of RCS development. Results of preclinical and clinical studies including recent Phase II/III clinical studies are discussed.
Duplex Microsphere-Based Immunoassay for Detection of Anti-West Nile Virus and Anti-St. Louis Encephalitis Virus Immunoglobulin M Antibodies (2005)

A microsphere-based immunoassay (MIA) was previously developed that is capable of determining the presence of anti-West Nile (WN) virus or anti-St. Louis encephalitis (SLE) virus immunoglobulin M (IgM) antibodies in human serum or cerebrospinal fluid. The original data set on which the classification rules were based comprised 491 serum specimens obtained from the serum bank at the Division of Vector-Borne Infectious Diseases of the Centers for Disease Control and Prevention (DVBID). The classification rules were used to provide a result and to determine whether confirmatory testing was necessary for a given sample. A validation study was coordinated between the DVBID and five state health laboratories to determine (i) the reproducibility of the test between different laboratories, (ii) the correlation between the IgM-enzyme-linked immunosorbent assay (MAC-ELISA) and the MIA, and (iii) whether the initial nonspecific parameters could be refined to reduce the volume of confirmatory testing. Laboratorians were trained in the method, and reagents and data analysis software developed at the DVBID were shipped to each validating laboratory. Validating laboratories performed tests on approximately 200 samples obtained from their individual states, the collections of which comprised approximately equal numbers of WN virus-positive and -negative samples, as determined by MAC-ELISA. In addition, 377 samples submitted to the DVBID for arbovirus testing were analyzed using the MIA and MAC-ELISA at the DVBID only. For the specimens tested at both the state and the DVBID laboratories, a correlation of results indicated that the technology is readily transferable between laboratories. The detection of IgM antibodies to WN virus was more consistent than detection of IgM antibodies to SLE virus. Some changes were made to the analysis software that resulted in an improved accuracy of diagnosis.
Structured Learning and Prediction in Computer Vision (2011)

Powerful statistical models that can be learned efficiently from large amounts of data are currently revolutionizing computer vision. These models possess a rich internal structure reflecting task-specific relations and constraints. This monograph introduces the reader to the most popular classes of structured models in computer vision. Our focus is discrete undirected graphical models which we cover in detail together with a description of algorithms for both probabilistic inference and maximum a posteriori inference. We discuss separately recently successful techniques for prediction in general structured models. In the second part of this monograph we describe methods for parameter learning where we distinguish the classic maximum likelihood based methods from the more recent prediction-based parameter learning methods. We highlight developments to enhance current models and discuss kernelized models and latent variable models. To make the monograph more practical and to provide links to further study we provide examples of successful application of many methods in the computer vision literature.
Characterization of a sulfotransferase responsible for the 4-O-sulfation of terminal beta-N-acetyl-D-galactosamine on asparagine-linked oligosaccharides of glycoprotein hormones. (1991)

The Asn-linked oligosaccharides on the glycoprotein hormones lutropin (LH) and thyrotropin terminate with the sequence SO4-4GalNAc beta 1-4GlcNAc beta 1-2 Man alpha-. Using a chemically synthesized trisaccharide GalNAc beta 1-4GlcNAc beta 1-2Man alpha 1-O(CH2)8COOCH3 (GGnM-MCO), we have developed a sensitive assay for the sulfotransferase responsible for the 4-O-sulfation of the terminal beta-D-GalNAc. GGnM-MCO is incubated with a bovine pituitary membrane extract and [35S]3'-phosphoadenosine 5'-phosphosulfate ([35S]PAPS). The sulfated product [35S]SGGnM-MCO is separated from [35S]PAPS, PAPS degradation products and endogenous sulfated products by a two-step procedure utilizing an Ecteola cellulose column and a Sep-Pak (C18) cartridge. Characterization of the [35S]SGGnM-MCO produced in the assay indicates that sulfate is incorporated exclusively on the 4-position of GalNAc. Linear incorporation of sulfate into GGnM-MCO can be maintained for greater than 10 h. GGnM-4-sulfotransferase has a pH optimum of 7.2, requires the presence of a reducing agent, and is stimulated by, but does not require, divalent cations. Initial velocity studies indicate an apparent Km (Henri-Michaelis-Menten equilibrium constant) for PAPS of 4 microM and for GGnM-MCO of 9 microM. Incorporation of sulfate into the trisaccharide is stimulated 3-fold by the presence of basic proteins including deglycosylated LH. The stimulation by deglycosylated LH suggests that the protein component of glycoproteins that bear oligosaccharides terminating with GalNAc-GlcNAc-Man- may modulate GGnM-4-sulfotransferase.
A low-IF direct sampling mixer with complex transfer function for ISDB-T one segment applications (2010)

A novel direct sampling mixer (DSM) with a complex transfer function has been developed for Integrated Service Digital Broadcasting-Terrestrial (ISDB-T) one segment applications. As its complex transfer function has an asymmetric frequency response with respect to clock frequency, an image rejection receiver can be realized with only one analog-to-digital converter (ADC) using the DSM. Furthermore, by using three-way, two-zero, three-pole IIR filters, a distinct deep notch shape is obtained at the image frequency. The proposed DSM was simulated using 65 nm CMOS technology, and an IRR of more than 25 dB was achieved. The architecture is appropriate for ISDB-T one-chip ICs.
Efficient wavelength conversion with high-power passively Q-switched diode-pumped neodymium lasers (1998)

Powerful CW diode-pumped Nd:YAG and Nd:YVO4 lasers Q-switched by Cr:YAG saturable absorbers demonstrate efficient (30%-60%) harmonic and parametric conversion, generating hundreds of milliwatts from ultraviolet to mid-infrared.
Lipid Rafts and HIV Pathogenesis: Virion-Associated Cholesterol Is Required for Fusion and Infection of Susceptible Cells (2003)

We have shown that HIV budding occurs at cholesterol-rich membrane microdomains called lipid rafts (Nguyen and Hildreth, J Virol 2000;74:3264-3272). This observation prompted us to examine the role in HIV entry of cholesterol in the membrane of cells. We recently reported that host cell cholesterol is required for HIV infection (Liao et al., AIDS Res Hum Retroviruses 2001;17:1009-1019). In the present study we examined the role of virion-associated cholesterol in HIV infection by modulating the cholesterol content of virions and infected cells with 2-hydoxypropyl-beta-cyclodextrin (beta-cyclodextrin). Our results show that removal of cholesterol from the membrane of HIV-infected cells dramatically lowered virus release and that virions released from cholesterol-depleted cells are minimally infectious. Exposure of infectious HIV particles to beta-cyclodextrin resulted in a dose-dependent inactivation of the virus. In both cases, the effect was attributable to loss of cholesterol and could be reversed by replenishing cholesterol. beta-Cyclodextrin-treated, noninfectious HIV retained its ability to bind cells. Western blot, p24 core ELISA, and reverse transcription assays indicated that virions remained intact after treatment with beta-cyclodextrin at concentrations that abolished infectivity. Electron microscopy revealed that beta-cyclodextrin-treated HIV had a morphology very similar to that of untreated virus. R18 fluorescence dequenching studies showed that beta-cyclodextrin-treated HIV did not fuse to the membrane of susceptible cells. Dequenching was restored by replenishing virion-associated cholesterol. The results indicate that cholesterol in HIV particles is strictly required for fusion and infectivity. These observations in combination with those of past studies indicate beta-cyclodextrin to be an excellent candidate for use as a chemical barrier for AIDS prophylaxis.
Adaptive combined DFE/MLSE techniques for ISI channels (1996)

By embedding a decision-feedback equalizer (DFE) into the structure of a maximum-likelihood sequence estimator (MLSE), an adaptive combined DFE/MLSE scheme is proposed. In this combined DFE/MLSE, the embedded DFE has three functions: (i) prefiltering the received signals and truncating the equivalent channel response into the desired one, (ii) compensating for channel distortions, and (iii) providing the MLSE detector with predicted values of input signals. Since the embedded MLSE detector operates on the predicted signals the detected symbols at the output of the DFE/MLSE do not suffer any delay and can be directly fed back into the embedded DFE so that the error propagation, which usually takes place in a conventional DFE, can be greatly reduced. Analytical and simulation results indicate that the performance is significantly improved by the DFE/MLSE compared to the conventional DFE while its computation complexity is much less than that of the conventional MLSE receiver. The combined DFE/MLSE can use different adaptive structures (block-updating, sliding window updating or symbol-by-symbol updating) to meet different performance objectives. Moreover, the proposed DFE/MLSE provides a trade-off between performance and complexity with a parameter m representing the MLSE detection depth as well as the number of predicting steps of the embedded DFE. For some particular values of m, this scheme is capable of emulating the conventional DFE, MLSE-VA, adaptive LE-MLSE equalizer, adaptive DDFSE, and adaptive BDFE without detection delay.
Characterization of (+)-Catechin−Acetaldehyde Polymers:  A Model for Colloidal State of Wine Polyphenols (1997)

The (+)-catechin−acetaldehyde condensation was studied as a model for tannin polymerization and precipitation in red wines. It was shown by using LSIMS that reaction products are catechin polymers with CH−CH3 bridges at two reaction sites. Before the end of monomer conversion into polymers there is an aggregation followed by a phase separation. Particle mean diameter was measured by dynamic light scattering directly in reaction medium. Comparison between particle and polymer sizes showed that polymers aggregate into colloidal intermediates before a large polymerization degree is reached. These particles then coagulate further, which leads to polymer precipitation. This colloidal behavior is explained by hydrophobic forces since aggregates and precipitate redissolve in ethanol. Keywords: Tannin; wine aging; colloid; catechin; acetaldehyde
Exploiting worm and allergy models to understand Th2 cytokine biology (2005)

Many findings from the schistosomiasis model have been subsequently demonstrated in models of allergic disease, illustrating the utility of this model to dissect basic mechanisms of Th2-mediated inflammation. Further study of helminth-induced Th2 responses may expedite the discovery of new therapeutics for a wide range of Th2-associated diseases.
Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women (2004)

Elevated levels of inflammatory markers, particularly C-reactive protein, indicate an increased risk of coronary heart disease. Although plasma lipid levels were more strongly associated with an increased risk than were inflammatory markers, the level of C-reactive protein remained a significant contributor to the prediction of coronary heart disease.
Basic character of rare earth metal alkoxides. Utilization in catalytic carbon-carbon bond-forming reactions and catalytic asymmetric nitroaldol reactions (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBasic character of rare earth metal alkoxides. Utilization in catalytic carbon-carbon bond-forming reactions and catalytic asymmetric nitroaldol reactionsHiroaki Sasai, Takeyuki Suzuki, Shigeru Arai, Takayoshi Arai, and Masakatsu ShibasakiCite this: J. Am. Chem. Soc. 1992, 114, 11, 4418–4420Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://pubs.acs.org/doi/10.1021/ja00037a068https://doi.org/10.1021/ja00037a068research-articleACS PublicationsRequest reuse permissionsArticle Views3657Altmetric-Citations562LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Practical Selective Hydrogenation of α-Fluorinated Esters with Bifunctional Pincer-Type Ruthenium(II) Catalysts Leading to Fluorinated Alcohols or Fluoral Hemiacetals (2013)

Selective hydrogenation of fluorinated esters with pincer-type bifunctional catalysts RuHCl(CO)(dpa) 1a, trans-RuH2(CO)(dpa) 1b, and trans-RuCl2(CO)(dpa) 1c under mild conditions proceeds rapidly to give the corresponding fluorinated alcohols or hemiacetals in good to excellent yields. Under the optimized conditions, the hydrogenation of chiral (R)-2-fluoropropionate proceeds smoothly to give the corresponding chiral alcohol without any serious decrease of the ee value.
Alignment‐Based Approach for Durable Data Storage into Living Organisms (2007)

The practical realization of DNA data storage is a major scientific goal. Here we introduce a simple, flexible, and robust data storage and retrieval method based on sequence alignment of the genomic DNA of living organisms. Duplicated data encoded by different oligonucleotide sequences was inserted redundantly into multiple loci of the Bacillus subtilis genome. Multiple alignment of the bit data sequences decoded by B. subtilis genome sequences enabled the retrieval of stable and compact data without the need for template DNA, parity checks, or error-correcting algorithms. Combined with the computational simulation of data retrieval from mutated message DNA, a practical use of this alignment-based method is discussed.
Conversion of Lignin with Supercritical Water−Phenol Mixtures (2003)

The decomposition of lignin was examined in supercritical water with and without phenol at 673 K. In the absence of phenol, the yield of tetrahydrofuran (THF)-insoluble (TIS) products decreased and the molecular weight distribution of THF-soluble (TS) products shifted toward lower molecular weights as the water density increased. The increase in water density enhanced the lignin conversion. In the presence of phenol, the yield of TIS products was lower and the molecular weight distribution of TS products shifted toward lower molecular weights than those in the absence of phenol. Some alkylphenols were obtained only in the presence of phenols, because of the reaction of phenol with the decomposition products. These results show that the reaction of phenol with reactive sites occurred in supercritical water and suppressed cross-linking reactions among reactive sites of large fragments. This promoted the decomposition of lignin to lower-molecular-weight compounds.
Effects of Essential Amino Acid Supplementation on Muscular Adaptations to 3 Weeks of Combined Unilateral Glenohumeral &amp; Radiohumeral Joints Immobilisation (2013)

Effects of Essential Amino Acid Supplementation on Muscular Adaptations to 3 Weeks of Combined Unilateral Glenohumeral & Radiohumeral Joints Immobilisation Short-term immobilisation results in a decrease in muscle size and strength. Ingestion of essential amino-acids (EAAs) stimulates net protein synthesis and supplementation is shown to improve lean body mass, strength and physical function, even without exercise. This study set out to determine whether EAA supplementation would attenuate immobilisation-induced changes in muscle characteristics.We conclude that EAA supplementation impacts positively on the immobilisation-induced changes in the structural and functional characteristic of the remaining muscle. Our findings are relevant to both sporting (e.g. off-season detraining
Profiles of the acute‐phase reactants C‐reactive protein and ferritin related to the disease course of patients with systemic lupus erythematosus (2003)

SLE is characterised by highly variable and unusual CRP and ferritin responses that do not always reflect the extent of inflammation in individual patients. Despite severe disease activity, ferritin levels can remain well within the normal range, limiting its clinical usefulness as a marker for disease activity.