gebhart/patrepeval huggingface dataset:
Management of intravaginal warts in women with 5-fluorouracil (1%) in vaginal hydrophilic gel: a placebo-controlled double-blind study (2000)

The purpose of this placebo-controlled, double-blind study was to determine the safety, tolerability and clinical efficacy of 5-fluorouracil (1%) in a vaginal hydrophilic gel (hydroxyethylcellulose, 1%) to cure intravaginal papillomas in women. Pre-selected, 60 women ranging between 18 and 50 years of age (mean 24.6), having 312 vaginal condylomas (mean 5.2) joined the study. The diagnosis of human papillomavirus (HPV) was established with clinical, histopathological and polymerase chain reaction (PCR) techniques. Subjects were randomized into 2 parallel groups. Each patient was allocated a pre-coded tube 15 g (active or placebo) with graduated vaginal applicators (disposable), and instructions how to insert 4 g of the trial medication deep into the vagina once at bedtime on every other day (1, 3 and 5) per week, to visit the clinic on day 7 for clinical evaluations and to receive the same pre-coded replacement to continue the regimen for another week. A maximum 12 applications were to be used in 4 weeks. Cure was defined as absence of clinical signs of infection, re-confirmed by PCR and Southern blot hybridization negative HPV DNA. By the end of the treatment 48.4% patients and 51.9% lesions were cured. Breaking the code revealed that 5-fluorouracil (1%) gel had cured 83.3% patients and 87% intravaginal warts. Placebo resolved 13.3% patients and 14% condylomas; (active gel versus placebo; P < 0.001). Twelve patients (20%) mostly in the active gel experienced mild erythema, erosion and oedema, with no drop-outs. Among cured patients 3 had a relapse after 16 months. In conclusion, the clinical results of the study demonstrate that 5-fluorouracil (1%) in a vaginal hydrophilic gel is safe, tolerable and significantly more effective than placebo to cure intravaginal warts in women.
Compositional characterization of prune juice (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCompositional characterization of prune juiceHendrik. Van Gorsel, Chingying. Li, Eduardo L. Kerbel, Mirjam. Smits, and Adel A. KaderCite this: J. Agric. Food Chem. 1992, 40, 5, 784–789Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://pubs.acs.org/doi/10.1021/jf00017a016https://doi.org/10.1021/jf00017a016research-articleACS PublicationsRequest reuse permissionsArticle Views453Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fluorescent Probes of Cell Signaling (1989)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Chromosomal alterations affecting the 1cen-1q12 region in buccal mucosal cells of betel quid chewers detected using multicolor fluorescence in situ hybridization (1997)

Epidemiological studies have shown that a high incidence of oral cancers is associated with chewing betel quid. Since chromosomal aberrations are involved in many types of cancers, we investigated whether increased frequencies of chromosomal alterations could be detected in the oral mucosa cells of betel quid chewers as compared to non-chewers. Due to the difficulty in culturing these epithelial cells, we used multicolor FISH with adjacent DNA probes to detect hyperdiploidy and breakage/exchanges affecting the 1cen-q12 region in interphase cells. Buccal mucosa cells from 19 male betel quid chewers and 23 non-chewers were hybridized and 1000 cells per donor were evaluated. A highly significant increase in the frequency of breakage affecting 1cen-1q12 region was observed in the mucosa cells of the chewers as compared to the non-chewers. A good correlation was also seen between breakage and duration of chewing. A modest increase in hyperdiploidy for chromosome 1 was also observed among chewers who had used betel quid for many years. These results indicate that this FISH approach can be useful for human biomonitoring, particularly for detecting alterations in non-dividing cells.
Low-Energy Ventricular Defibrillation and Miniature Defibrillators (1976)

<h3>To the Editor.—</h3> When discussing transthoracic ventricular defibrillation, Loeb (232:845, 1975; 235:144, 1976) and Tacker et al (235:144, 1976) overlooked both direct-current (DC) countershock using low-level electrical energy and miniature defibrillators. More than 35 years ago, Wiggers<sup>1</sup>showed that serial low-energy shocks expedite ventricular defibrillation. Recent experiments, corroborating and extending these earlier observations, indicate that only a limited critical mass of ventricle need be defibrillated for restoration of intrinsic cardiac pacemaker function.<sup>2</sup>In humans, prospective investigation of transthoracic defibrillation showed that the stored 200 watt-second (W-sec) DC shock provided an average 3.1 (1.8-4.0) W-sec/kg. This 200 W-sec shock eliminated primary ventricular fibrillation on the first shock in 73 and on the second shock in 7 of 80 cardiac patients. Two others needed higher energy levels for defibrillation.<sup>3</sup>Our early experience confirms this report (Table). Thus, 86 episodes of prospectively assessed human ventricular fibrillation responded to an average
Feedback-free packet loss recovery for video multicast (2004)

In video streaming over multicast networks, error recovery is essential to alleviate the effect of packet loss. In this paper, we study a feedback-free recovery scheme which combines the strength of FEC (namely, a parity packet can repair any lost packet) and pseudo-ARQ (namely, incremental recovery). To account for the receiver heterogeneity, the server multicasts layered video streams for the receivers to join. For each layer, the receivers may join dynamically additional multicast channels of FEC and pseudo-ARQ packets to recover local losses. In order to offer quality video, we address the following issues: 1) "menu creation": given a certain maximum error rate after correction (i.e., residual error rate), what is the combination of FEC and pseudo-ARQ packets for the server to send so as to minimize a target receiver's bandwidth; and 2) "menu selection": given the server's menu, what's the combination of FEC and pseudo-ARQ packets for the receiver to join so as to minimize its residual error rate given its local probability, bandwidth and loss pattern. We present the analysis of the scheme and show that our scheme can substantially reduce a receiver's residual error rate as compared with pure FEC or pure pseudo-ARQ alone (by cutting it as much as half).
Total body irradiation selectively induces murine hematopoietic stem cell senescence (2005)

Exposure to ionizing radiation (IR) and certain chemotherapeutic agents not only causes acute bone marrow (BM) suppression but also leads to long-term residual hematopoietic injury. This latter effect has been attributed to damage to hematopoietic stem cell (HSC) self-renewal. Using a mouse model, we investigated whether IR induces senescence in HSCs, as induction of HSC senescence can lead to the defect in HSC self-renewal. It was found that exposure of C57BL/6 mice to a sublethal dose (6.5 Gy) of total body irradiation (TBI) resulted in a sustained quantitative and qualitative reduction of LKS+ HSCs. In addition, LKS+ HSCs from irradiated mice exhibited an increased expression of the 2 commonly used biomarkers of cellular senescence, p16(Ink4a) and SA-beta-gal. In contrast, no such changes were observed in irradiated LKS- hematopoietic progenitor cells. These results provide the first direct evidence demonstrating that IR exposure can selectively induce HSC senescence. Of interest, the induction of HSC senescence was associated with a prolonged elevation of p21(Cip1/Waf1), p19(Arf), and p16(Ink4a) mRNA expression, while the expression of p27(Kip1) and p18(Ink4c) mRNA was not increased following TBI. This suggests that p21(Cip1/Waf1), p19(Arf), and p16(Ink4a) may play an important role in IR-induced senescence in HSCs.
Die Anwendung von Healon<sup>®</sup>bei extrakapsulärer Kataraktextraktion und bei der Implantation von intraokularen Linsen (1981)

The use of Healon 1% hyaluronic acid increases the safety of implant operations. The result is a decrease in the number of cases where implantation employing conventional techniques has to be abandoned on account of complications during surgery. Our experience of 65 implants with follow-ups ranging from two to 30 months is presented. A detailed description of the technique and postoperative problems is given.
Deposition of silicon dioxide and silicon nitride by remote plasma enhanced chemical vapor deposition (1986)

We have developed a low temperature process for the deposition of thin films of silicon dioxide and silicon nitride. The process consists of four steps: (a) excitation of an oxygen or nitrogen-containing molecule in an RF plasma; (b) transport of the excited oxygen or nitrogen species out of the plasma region; (c) mixing of the transported excited species with silane (or disilane) out of the plasma region to form precursor species; and (d) a CVD reaction at a heated substrate to form the desired thin film. We call this process remote plasma enhanced CVD (RPECVD). Silicon rich oxide films have been grown at substrate temperatures (Ts) between 100 and 350 °C using an excited O2/He mixture. Two different ‘‘silicon nitrides’’ have been deposited depending on the excited gas, NH3 or an N2/He mixture, and Ts. Using either nitrogen source and Ts greater than 450 °C, we obtain near stoichiometric films of Si3N4. On the other hand, films grown from NH3 and deposited with Ts of about 50 to 100 °C are silicon diimide [Si(NH)2], which is isostructural with respect to SiO2 with bridging NH groups substituted for the bridging oxygen atoms. Films grown from the NH3 source and at Ts between 150 and 450 °C are solid solutions of silicon nitride and silicon diimide. We discuss the application of these dielectric films in device structures.
Australian IPv6 Readiness: Results of a National Survey (2012)

IPv6 is the replacement for the Internet’s incumbent protocol, IPv4. Although exhaustion of the IPv4 address space is now imminent there has been no meaningful uptake of IPv6 since its standardisation in 1998. Data from a national survey of the top 1,000 IT user organisations in Australia are analysed, revealing that they have made little or no preparation for IPv6. This creates the potential for considerable disadvantage for Australian organisations. The author recommends that governments and regulatory bodies should consider regulatory or policy action to encourage the diffusion of IPv6. The author also recommends that enterprise organisations develop a long-term IPv6 strategy, implement IPv6 training programs, update their policy frameworks, and assess their IT assets and applications portfolios.
Novel Temperature-Sensitive Liposomes with Prolonged Circulation Time (2004)

Hyperthermia increases the efficiency of various chemotherapeutic drugs and is administered as an adjunct to chemotherapy for the treatment of cancer patients. The temperature-dependent effect can be strongly increased by the use of temperature-sensitive liposomes in combination with regional hyperthermia, which specifically releases the entrapped drug in the heated tumor tissue. The novel lipid 1.2-dipalmitoyl-sn-glycero-3-phosphoglyceroglycerol (DPPGOG), which is closely related to the naturally occurring 1.2-dipalmitoyl-sn-glycero-3-phosphoglycerol, in combination with 1.2-dipalmitoyl-sn-glycero-3-phosphocholine and 1.2-distearoyl-sn-glycero-3-phosphocholine provides long-circulating temperature-sensitive liposomes with favorable properties under mildly hyperthermic conditions (41-42 degrees C). DPPGOG facilitates temperature-triggered drug release from these liposomes (diameter, 175 nm) and leads to a substantially prolonged plasma half-life for the encapsulated drug with t(1/2) = 9.6 h in hamsters and t(1/2) = 5.0 h in rats. Quantitative fluorescence microscopy of amelanotic melanoma grown in the transparent dorsal skin fold chamber of hamsters demonstrated a favorable drug accumulation in heated tissue after i.v. application of these liposomes (42 degrees C for 1 h). The mean area under the curve for tissue drug concentration was increased by more than sixfold by application of the new liposomes compared with nonliposomal drug delivery. In summary, we present a new DPPGOG-based liposomal formulation enabling long circulation time combined with fast and efficient drug release under mild hyperthermia. This adds positively to the results with lipid-grafted polyethylenglycol used thus far in temperature sensitive liposomes and widens the possibilities for clinical applications.
Combined description of shape and motion in an object based coding scheme using curved triangles (2002)

We present an approach to a unified representation of motion and shape of objects in a video scene. Starting from given object masks, we outline an algorithm for the construction of grids consisting of regular and/or curved triangles. Hence the object shape is given as a polygon or a number of consecutive arcs, while the object motion can be approximated through tracking of the grid points. The prediction images are finally rendered by warping a reference frame according to the deformed grid.
Adaptor protein Disabled-2 modulates low density lipoprotein receptor synthesis in fibroblasts from patients with autosomal recessive hypercholesterolaemia (2007)

Autosomal recessive hypercholesterolaemia (ARH), characterized clinically by severe inherited hypercholesterolaemia, is caused by recessive null mutations in LDLRAP1 (formerly ARH). Immortalized lymphocytes and monocyte-macrophages, and presumably hepatocytes, from ARH patients fail to take up and degrade plasma low density lipoproteins (LDL) because they lack LDLRAP1, a cargo-specific adaptor required for clathrin-mediated endocytosis of the LDL receptor. Surprisingly, LDL-receptor function is normal in ARH patients' skin fibroblasts in culture. Disabled-2 (Dab2) has been implicated previously in clathrin-mediated internalization of LDL-receptor family members, and we show here that Dab2 is highly expressed in skin fibroblasts, but not in lymphocytes. SiRNA-depletion of Dab2 profoundly reduced LDL-receptor activity in ARH fibroblasts as a result of profound reduction in LDL-receptor protein, but not mRNA; heterologous expression of murine Dab2 reversed this effect. In contrast, LDL-receptor protein content was unchanged in Dab-2-depleted control cells. Incorporation of 35S-labelled amino acids into LDL receptor protein revealed a corresponding apparent reduction in accumulation of newly synthesized LDL-receptor protein on depletion of Dab2 in ARH, but not in control, cells. This reduction in LDL-receptor protein in Dab2-depleted ARH cells could not be reversed by treatment of the cells with proteasomal or lysosomal inhibitors. Thus, we propose a novel role for Dab2 in ARH fibroblasts, where it is apparently required to allow normal translation of LDL receptor mRNA.
WirePrint (2014)

Even though considered a rapid prototyping tool, 3D printing is so slow that a reasonably sized object requires printing overnight. This slows designers down to a single iteration per day. In this paper, we propose to instead print low-fidelity wireframe previews in the early stages of the design process. Wireframe previews are 3D prints in which surfaces have been replaced with a wireframe mesh. Since wireframe previews are to scale and represent the overall shape of the 3D object, they allow users to quickly verify key aspects of their 3D design, such as the ergonomic fit. To maximize the speed-up, we instruct 3D printers to extrude filament not layer-by-layer, but directly in 3D-space, allowing them to create the edges of the wireframe model directly one stroke at a time. This allows us to achieve speed-ups of up to a factor of 10 compared to traditional layer-based printing. We demonstrate how to achieve wireframe previews on standard FDM 3D printers, such as the PrintrBot or the Kossel mini. Users only need to install the WirePrint software, making our approach applicable to many 3D printers already in use today. Finally, wireframe previews use only a fraction of material required for a regular print, making it even more affordable to iterate.
Clinical consequences of exposing pregnant gilts to strains of porcine reproductive and respiratory syndrome (PRRS) virus isolated from field cases of "atypical" PRRS. (1998)

Some strains of PRRSV now circulating in US swine herds are more virulent than those encountered in the past. Clinical PRRS in vaccinated herds suggests need for a new generation of vaccines.
Separation of fat and water in fast spin‐echo MR imaging with the three‐point dixon technique (1995)

A method for suppressing fat in fast spin-echo imaging with the three-point Dixon technique is described. The method differs from the three-point Dixon method used in conventional spin-echo imaging in that the readout gradient instead of a radio-frequency pulse is shifted. This method preserves the Carr-Purcell-Meiboom-Gill nature of the fast spin-echo sequence and hence is less sensitive to magnetic field inhomogeneities and resonance frequency mistuning. As in the original three-point Dixon technique used in conventional spin-echo imaging, three acquisitions are required to estimate the field inhomogeneity and completely separate fat and water. The extra time required is not excessive considering that the fast spin-echo method is frequently applied with multiple signal acquisition. Also, this technique achieves an expected signal-to-noise ratio comparable to 2.67 signal acquisitions, which is approximately 94% of the signal-to-noise ratio obtained with three signal acquisitions. The method is demonstrated with applications to phantoms and a human volunteer.
Learning to Extract a Video Sequence from a Single Motion-Blurred Image (2018)

We present a method to extract a video sequence from a single motion-blurred image. Motion-blurred images are the result of an averaging process, where instant frames are accumulated over time during the exposure of the sensor. Unfortunately, reversing this process is nontrivial. Firstly, averaging destroys the temporal ordering of the frames. Secondly, the recovery of a single frame is a blind deconvolution task, which is highly ill-posed. We present a deep learning scheme that gradually reconstructs a temporal ordering by sequentially extracting pairs of frames. Our main contribution is to introduce loss functions invariant to the temporal order. This lets a neural network choose during training what frame to output among the possible combinations. We also address the ill-posedness of deblurring by designing a network with a large receptive field and implemented via resampling to achieve a higher computational efficiency. Our proposed method can successfully retrieve sharp image sequences from a single motion blurred image and can generalize well on synthetic and real datasets captured with different cameras.
Laundry Detergents: An Overview (2007)

Nowadays laundry detergents are becoming increasingly popular as they can be metered automatically into the washing machine, impart softness, antistaticness, resiliency to fabrics, mild to eyes and skins and shows good dispersibility in water. Because it is consumed when it is used, the sale of laundry detergent is a rather large business. There are many different kinds or brands of laundry detergent sold, many of them claiming some special qualities as selling points. A Laundry detergent composition is a formulated mixture of raw materials that can be classified into different types based on their properties and function in the final product. The different classes of raw materials are surfactants, builders, bleaching agents, enzymes, and minors which remove dirt, stain, and soil from surfaces or textiles gave them pleasant feel and odour. The physico-chemical properties of surfactants make them suitable for laundry purposes. Laundry detergent has traditionally been a powdered or granular solid, but the use of liquid laundry detergents has gradually increased over the years, and these days use of liquid detergent equals or even exceeds use of solid detergent. This review paper describes the history, composition, types, mechanism, consumption, environmental effects and consumption of laundry detergents.
Battery balancing methods: A comprehensive review (2008)

The trend toward more electric vehicles has demanded the need for high voltage, high efficiency and long life battery systems. A complete battery system consists of the following parts: protection, management and balancing. Of the three parts, balancing is the most important concerning the life of the battery system because without the balancing system, the individual cell voltages will drift apart over time. The capacity of the total pack will also decrease more quickly during operation which will result in the fail of the total battery system. This condition is especially severe when the battery has a long string of cells (high voltage battery systems) and frequent regenerative braking (charging) is done via the battery pack. This paper presents the theory behind the proposed balancing methods for battery systems within the past twenty years. Comparison between the methods is carried out and different balancing methods are grouped by their nature of balancing.
Real-time planning of humanoid robot's gait for force controlled manipulation (2004)

This work proposes a new style of manipulation by a humanoid robot. Focusing on the task of pushing an object, the foot placement of it is planed in real-time according to the result of manipulation of an object. By controlling the arms using the impedance control, a humanoid robot can push an object stably regardless of the mass of an object. If an object is heavy, a humanoid robot pushes an object with walking slowly, and vice versa. Also, for planning the gait in real-time, we newly propose an analytical method where the newly calculated trajectory of the robot motion is smoothly connected to the current one. The effectiveness of the proposed method is confirmed by simulation and experiment.