gebhart/patrepeval huggingface dataset:
&lt;title&gt;Design guidelines for medical ultrasonic arrays&lt;/title&gt; (1998)

The basics of ultrasonic transducer array design in the frequency range useful for medical imaging are discussed. Performance parameters of importance in transducer design are considered, including sensitivity, coupling constant, band width, frequency downshift, pulse duration, beam focusing properties, and electrical matching. 2D and 3D effects must also be taken into account. The advantages of computer modeling in 3D with finite element analysis code are highlighted. The principles of multi-element array transducers useful for 2D real-time scanning are reviewed. 2D arrays provide the opportunity of focusing the elevation beam dimension in the short axis, or make possible full 3D scanning volumes.
Actuating and detecting of microdroplet using slanted finger interdigital transducers (2005)

Using surface acoustic wave (SAW) to drive droplets on a piezoelectric chip is a distinctive microfluidic technique developed recently. In the previous research, uniform interdigital transducers (IDTs) were used to radiate SAW amplitude and move the droplets within the same delay line simultaneously. In this paper, we employ slanted finger interdigital transducers (SFITs) to replace uniform IDTs. The merit is that we can move individual droplets at will by varying the frequency. This is because SAW amplitude profile actuated by a SFIT is not uniform along the aperture. The position of the maximum amplitude can be changed by adjusting the input frequency. In addition, we apply the coupling-of-modes model to simulate the amplitude profile and the frequency response of SFITs. Since the transmitted SAW intensity is strongly attenuated by the liquid when SAW hits the droplet, we can use the measured frequency response to detect the position of the droplet and verify the validity of the proposed method; we fabricated a SFIT on an Y128X-LiNbO3 substrate coated with hydrophobic film. The experimental results show good agreement with those predicted by the simulations. We note that the proposed method can further be used to construct a multichannel microfluidic chip.
Achieving Hemostasis With Topical Hemostats: Making Clinically and Economically Appropriate Decisions in the Surgical and Trauma Settings (2011)

Achieving hemostasis is a crucial focus of clinicians working in surgical and trauma settings. Topical hemostatic agents-including mechanical hemostats, active hemostats, flowable hemostats, and fibrin sealants-are frequently used in efforts to control bleeding, and new options such as hemostatic dressings, initially used in combat situations, are increasingly being used in civilian settings. To achieve successful hemostasis, a number of vital factors must be considered by surgeons and perioperative nurses, such as the size of the wound; bleeding severity; and the efficacy, possible adverse effects, and method of application of potential hemostatic agents. Understanding how and when to use each of the available hemostatic agents can greatly affect clinical outcomes and help to limit the overall cost of treatment.
Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cells (2009)

(1) Due to the weak concordance between CTCs and DTCs the clinical relevance may be different. (2) The biology of the primary tumor seems to direct the spread of CTCs. (3) Since the expression profile between CTCs and the primary tumor differs, the consequence for the selection of adjuvant treatment has to be evaluated.
Group Anomaly Detection using Flexible Genre Models (2018)

An important task in exploring and analyzing real-world data sets is to detect unusual and interesting phenomena. In this paper, we study the group anomaly detection problem. Unlike traditional anomaly detection research that focuses on data points, our goal is to discover anomalous aggregated behaviors of groups of points. For this purpose, we propose the Flexible Genre Model (FGM). FGM is designed to characterize data groups at both the point level and the group level so as to detect various types of group anomalies. We evaluate the effectiveness of FGM on both synthetic and real data sets including images and turbulence data, and show that it is superior to existing approaches in detecting group anomalies.
Tetrahedral irradiation protocol for microbeam radiation therapy (2006)

Optimizing microbeam radiation therapy requires that the patient be repositioned between exposures. Optional movements of a patient-gantry are described that would enable a lesion to be cross-fired pseudo-orthogonally in two, three or four exposures to a fixed, horizontally propagated array of vertical, parallel microplanar beams, with minimal tilting of the patient-gantry.
An Expedient Reduction of<i>sec</i>-Phosphine Oxides to<i>sec</i>-Phosphine-boranesby BH<sub>3</sub>˙SMe<sub>2</sub> (2003)

Secondary phosphine oxides can be expeditiously converted into secondary phosphine-boranes by treatment with an excess of BH3˙SMe2 at room temperature. Selectivity of the conversion towards the formation of secondary phosphine-boranes is greatly improved by the addition of a small amount of water to the reaction mixture.
Reduction and Coordination of Arsenic in Indian Mustard (2000)

The bioaccumulation of arsenic by plants may provide a means of removing this element from contaminated soils and waters. However, to optimize this process it is important to understand the biological mechanisms involved. Using a combination of techniques, including x-ray absorption spectroscopy, we have established the biochemical fate of arsenic taken up by Indian mustard (Brassica juncea). After arsenate uptake by the roots, possibly via the phosphate transport mechanism, a small fraction is exported to the shoot via the xylem as the oxyanions arsenate and arsenite. Once in the shoot, the arsenic is stored as an As(III)-tris-thiolate complex. The majority of the arsenic remains in the roots as an As(III)-tris-thiolate complex, which is indistinguishable from that found in the shoots and from As(III)-tris-glutathione. The thiolate donors are thus probably either glutathione or phytochelatins. The addition of the dithiol arsenic chelator dimercaptosuccinate to the hydroponic culture medium caused a 5-fold-increased arsenic level in the leaves, although the total arsenic accumulation was only marginally increased. This suggests that the addition of dimercaptosuccinate to arsenic-contaminated soils may provide a way to promote arsenic bioaccumulation in plant shoots, a process that will be essential for the development of an efficient phytoremediation strategy for this element.
On the calculation of p<i>K</i><sub>a</sub>s in proteins (1993)

This paper describes a general method to calculate the pKas of ionizable groups in proteins. Electrostatic calculations are carried out using the finite difference Poisson-Boltzmann (FDPB) method. A formal treatment of the calculation of pKas within the framework of the FDPB method is presented. The major change with respect to previous work is the specific incorporation of the complete charge distribution of both the neutral and charged forms of each ionizable group into the formalism. This is extremely important for the treatment of salt bridges. A hybrid statistical mechanical/Tanford-Roxby method, which is found to be significantly faster than previous treatments, is also introduced. This simplifies the problem of summing over the large number of possible ionization states for a complex polyion. Applications to BPTI and serine proteases suggest that the calculations can be quite reliable. However, the necessity of including bound waters in the treatment of the Asp-70... His-31 salt bridge in T4 lysozyme and experience with other proteins suggest that additional factors ultimately need to be considered in a comprehensive treatment of pKas in proteins.
Molecular Cloning and Characterization of Tetrahydroprotoberberine cis-N-Methyltransferase, an Enzyme Involved in Alkaloid Biosynthesis in Opium Poppy (2007)

S-Adenosyl-l-methionine:tetrahydroprotoberberine cis-N-methyltransferase (EC 2.1.1.122) catalyzes the conversion of (S)-stylopine to the quaternary ammonium alkaloid, (S)-cis-N-methylstylopine, as a key step in the biosynthesis of protopine and benzophenanthridine alkaloids in plants. A full-length cDNA encoding a protein exhibiting 45 and 48% amino acid identity with coclaurine N-methyltransferase from Papaver somniferum (opium poppy) and Coptis japonica, respectively, was identified in an elicitor-treated opium poppy cell culture expressed sequence tag data base. Phylogenetic analysis showed that the protein belongs to a unique clade of enzymes that includes coclaurine N-methyltransferase, the predicated translation products of the Arabidopsis thaliana genes, At4g33110 and At4g33120, and bacterial S-adenosyl-L-methionine-dependent cyclopropane fatty acid synthases. Expression of the cDNA in Escherichia coli produced a recombinant enzyme able to convert the protoberberine alkaloids stylopine, canadine, and tetrahydropalmatine to their corresponding N-methylated derivatives. However, the protoberberine alkaloids tetrahydroxyberbine and scoulerine, and simple isoquinoline, benzylisoquinoline, and pavine alkaloids were not accepted as substrates, demonstrating the strict specificity of the enzyme. The apparent K(m) values for (R,S)-stylopine and S-adenosyl-L-methionine were 0.6 and 11.5 microm, respectively. TNMT gene transcripts and enzyme activity were detected in opium poppy seedlings and all mature plant organs and were induced in cultured opium poppy cells after treatment with a fungal elicitor. The enzyme was detected in cell cultures of other members of the Papaveraceae but not in species of related plant families that do not accumulate protopine and benzophenanthridine alkaloids.
Delayed kinetics of DNA double‐strand break processing in normal and pathological aging (2007)

Accumulation of DNA damage may play an essential role in both cellular senescence and organismal aging. The ability of cells to sense and repair DNA damage declines with age. However, the underlying molecular mechanism for this age-dependent decline is still elusive. To understand quantitative and qualitative changes in the DNA damage response during human aging, DNA damage-induced foci of phosphorylated histone H2AX (gamma-H2AX), which occurs specifically at sites of DNA double-strand breaks (DSBs) and eroded telomeres, were examined in human young and senescing fibroblasts, and in lymphocytes of peripheral blood. Here, we show that the incidence of endogenous gamma-H2AX foci increases with age. Fibroblasts taken from patients with Werner syndrome, a disorder associated with premature aging, genomic instability and increased incidence of cancer, exhibited considerably higher incidence of gamma-H2AX foci than those taken from normal donors of comparable age. Further increases in gamma-H2AX focal incidence occurred in culture as both normal and Werner syndrome fibroblasts progressed toward senescence. The rates of recruitment of DSB repair proteins to gamma-H2AX foci correlated inversely with age for both normal and Werner syndrome donors, perhaps due in part to the slower growth of gamma-H2AX foci in older donors. Because genomic stability may depend on the efficient processing of DSBs, and hence the rapid formation of gamma-H2AX foci and the rapid accumulation of DSB repair proteins on these foci at sites of nascent DSBs, our findings suggest that decreasing efficiency in these processes may contribute to genome instability associated with normal and pathological aging.
A scalable ATM switching system architecture (1991)

The architecture of an asynchronous transfer mode (ATM) switching system for prototype applications is presented. The general concept to upgrade the existing ISDN switch with an ATM module is introduced, and the building blocks of this ATM module are described in detail. Switching of ATM cells is performed in a single application-specific integrated circuit (ASIC). ASICs can be cascaded to form large switching modules. Peripheral modules interface the ATM switch to external transmission systems and perform all ATM-related functions, including means for redundancy of the switching network. The redundancy scheme tolerates single failures without affecting the user information. A switching network architecture is shown to be capable of fulfilling varying demands in terms of the number of ports for ATM switches and cross connects, concentrators, and multiplexers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Serum Cholesterol Precursors, Cholestanol, and Plant Sterols in Primary Biliary Cirrhosis (1988)

We measured serum cholesterol precursors (squalene, delta 8-cholestenol, desmosterol, lathosterol, cholestanol) and plant sterols (campesterol, sitosterol, and avenasterol) from 11 patients (one man) with primary biliary cirrhosis (PBC) and 13 healthy women matched for age and weight. In PBC serum total cholesterol was increased (9.4 versus 5.9 mmol/l; p less than 0.05), whereas serum cholestanol in terms of mmol/mol of cholesterol was elevated fourfold. In similar terms, serum plant sterols, especially sitosterol and avenasterol, were modestly increased, whereas most of serum cholesterol precursors were decreased. The serum contents of cholestanol were negatively associated with those of serum cholesterol precursors and positively with those of sitosterol and avenasterol with the serum cholesterol concentration. The liver function tests were positively related to serum cholestanol contents (r value ranged from 0.588 to 0.839 for alkaline phosphatase, aspartate aminotransferase, alanine amino-transferase, and bilirubin). The findings suggest that in cholestatic liver disease reduced serum cholesterol precursor contents reflect reduced cholesterol synthesis, whereas increased serum plant sterol and cholestanol contents are determined mainly by impaired biliary elimination.
Powered Lower Limb Orthoses for Gait Rehabilitation (2005)

Bodyweight supported treadmill training has become a prominent gait rehabilitation method in leading rehabilitation centers. This type of locomotor training has many functional benefits but the labor costs are considerable. To reduce therapist effort, several groups have developed large robotic devices for assisting treadmill stepping. A complementary approach that has not been adequately explored is to use powered lower limb orthoses for locomotor training. Recent advances in robotic technology have made lightweight powered orthoses feasible and practical. An advantage to using powered orthoses as rehabilitation aids is they allow practice starting, turning, stopping, and avoiding obstacles during overground walking.
Guidelines for Using Negative Pressure Wound Therapy (2001)

PURPOSE To present information on the rationale for and use of negative pressure wound therapy. TARGET AUDIENCE This CME/CE activity is intended for physicians and nurses with an interest in using negative pressure therapy in the treatment of wounds. LEARNING OBJECTIVES Describe the rationale for using negative pressure in the treatment of wounds. Discuss guidelines for the appropriate use of negative pressure wound therapy. Identify patients with wounds who would benefit from negative pressure wound therapy and patients for whom this modality would be contraindicated.
CACH-FTL: A Cache-Aware Configurable Hybrid Flash Translation Layer (2013)

Many hybrid Flash Translation Layer (FTL) schemes have been proposed to leverage the erase-before-write and limited lifetime constraints of flash memories. Those schemes try to approach page mapping performance and flexibility while seeking block mapping memory usage. Furthermore, flash-specific cache systems were designed (1) to maximize lifetime by absorbing some erase operations, and (2) to reveal sequentiality from random write operations. Indeed, random writes represent the Achilles' heel of flash memories. Both cache systems and FTL schemes were designed independently from each other. This paper presents a scalable (in terms of mapping table size) and flexible (in terms of I/O workload support) Cache-Aware Configurable Hybrid (CACH) FTL. CACH-FTL uses a common feature of flash-specific cache systems that is flushing groups of pages from the same block. CACH-FTL partitions the flash memory space into two regions: (1) a data Block Mapped Region (BMR) collecting large groups of pages from the above cache (sequential I/Os), and (2) a small Page Mapped over-provisioning Region (PMR) which purpose is to collect/buffer small groups of pages coming from the cache (random I/Os) before moving them to BMR. CACH-FTL is flexible as it offers many configuration possibilities and can be adapted according to the I/O workload. CACH-FTL approaches the ideal page mapping FTL performance as it gives less than 15% performance difference in most cases.
Epileptic Focus Stimulation and Seizure Control in the Rat Model of Kainic Acid-Induced Limbic Seizures (2010)

The inhibitory effects of deep brain stimulation (DBS) were investigated in a rat model of kainic acid (KA)-induced limbic status epilepticus. Wistar rats were injected with 1.0 microg KA into the left amygdala after stereotactic implantation of a guide cannula and electrodes. Bipolar rectangular pulses of 0.1 msec duration and 0.1-0.3 mA amplitude were applied intermittently to the left amygdala (10 Hz or 130 Hz), left ventral hippocampus (10 Hz), and left dorsomedial thalamus (130 Hz). Seizure frequency was evaluated by video electroencephalography monitoring and compared to control animals that did not receive DBS. All rats developed limbic status epilepticus 60-90 minutes after KA injection. Seizure frequency was significantly reduced by 10 Hz stimulation of the amygdala and by 130 Hz stimulation of the dorsomedial thalamus. No significant effects were observed with other types of stimulation. Seizure behaviors or duration of seizure were not changed significantly by DBS treatment. DBS of an epileptic focus may attenuate KA-induced limbic seizures, depending on the stimulation sites and parameters.
Details of the Nitech HMM-Based Speech Synthesis System for the Blizzard Challenge 2005 (2007)

In January 2005, an open evaluation of corpus-based text-to-speech synthesis systems using common speech datasets, named Blizzard Challenge 2005, was conducted. Nitech group participated in this challenge, entering an HMM-based speech synthesis system called Nitech-HTS 2005. This paper describes the technical details, building processes, and performance of our system. We first give an overview of the basic HMM-based speech synthesis system, and then describe new features integrated into Nitech-HTS 2005 such as STRAIGHT-based vocoding, HSMM-based acoustic modeling, and a speech parameter generation algorithm considering GV. Constructed Nitech-HTS 2005 voices can generate speech waveforms at 0.3 ×RT (real-time ratio) on a 1.6 GHz Pentium 4 machine, and footprints of these voices are less than 2 Mbytes. Subjective listening tests showed that the naturalness and intelligibility of the Nitech-HTS 2005 voices were much better than expected.
PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis (2004)

Platelet-derived growth factor-D (PDGF-D) is a recently characterized member of the PDGF family with unknown in vivo functions. We investigated the effects of PDGF-D in transgenic mice by expressing it in basal epidermal cells and then analyzed skin histology, interstitial fluid pressure, and wound healing. When compared with control mice, PDGF-D transgenic mice displayed increased numbers of macrophages and elevated interstitial fluid pressure in the dermis. Wound healing in the transgenic mice was characterized by increased cell density and enhanced recruitment of macrophages. Macrophage recruitment was also the characteristic response when PDGF-D was expressed in skeletal muscle or ear by an adeno-associated virus vector. Combined expression of PDGF-D with vascular endothelial growth factor-E (VEGF-E) led to increased pericyte/smooth muscle cell coating of the VEGF-E-induced vessels and inhibition of the vascular leakiness that accompanies VEGF-E-induced angiogenesis. These results show that full-length PDGF-D is activated in tissues and is capable of increasing interstitial fluid pressure and macrophage recruitment and the maturation of blood vessels in angiogenic processes.
An interferon‐γ‐related cytokine storm in SARS patients (2004)

Fourteen cytokines or chemokines were analyzed on 88 RT-PCR-confirmed severe acute respiratory syndrome (SARS) patients. IFN-gamma, IL-18, TGF-beta, IL-6, IP-10, MCP-1, MIG, and IL-8, but not of TNF-alpha, IL-2, IL-4, IL-10, IL-13, or TNFRI, were highly elevated in the acute phase sera of Taiwan SARS patients. IFN-gamma was significantly higher in the Ab(+) group than in the Ab(-) group. IFN-gamma, IL-18, MCP-1, MIG, and IP-10 were already elevated at early days post fever onset. Furthermore, levels of IL-18, IP-10, MIG, and MCP-1 were significantly higher in the death group than in the survival group. For the survival group, IFN-gamma and MCP-1 were inversely associated with circulating lymphocytes count and monocytes count, but positively associated with circulating neutrophils count. It is concluded that an interferon-gamma-related cytokine storm was induced post SARS coronavirus infection, and this cytokine storm might be involved in the immunopathological damage in SARS patients.
Synthesis of Mo and W Carbide and Nitride Nanoparticles via a Simple “Urea Glass” Route (2008)

A simple, inexpensive, and versatile route for the synthesis of metal nitrides and carbides (such as Mo2N, Mo2C, W2N and WC) nanoparticles was set up. For the first time, metal carbides were obtained using urea as carbon-source. MoCl5 and WCl4 are in a first step contacted with alcohols and an appropriate amount of urea to form a polymer-like, glassy phase, which acts as the starting product for further conversions. Just by heating this phase it was possible to prepare either molybdenum and tungsten nitrides or carbides simply by changing the metal precursor/urea molar ratio. In this procedure, urea plays a double role as a nitrogen/carbon source and stabilizing agent (necessary for the nanoparticle dispersion). Molybdenum and tungsten nitride and carbides synthesized are almost pure and highly crystalline. Sizes estimated by WAXS range around 20 and 4 nm in diameter for Mo and W nitrides or carbides, respectively. The specific surface area was found between 10 and 80 m2/g, depending on the metal and the initial ratio of metal precursor to urea.