gebhart/patrepeval huggingface dataset:
Radiolabeling of proteins with radioisotopes of copper using p‐carboxyalkylphenylglyoxal bis‐(<sup>4</sup>N‐methylthiosemicarbazone) (TSC) bifunctional chelates (1990)

Abstract A series of p‐carboxyalkylphenylglyoxal and p‐carboxyalkyl‐1,2‐diketo‐bis‐(N 4 ‐methylthiosemicarbazone) bifunctional ligands (TSC) have been prepared and evaluated for use in binding radioisotopes of copper to antibodies. We have developed an improved synthesis of the requisite α‐ketoaldehyde and 1,2‐diketone substrates used for derivatization to the bis‐TSC bifunctional chelates. This approach utilizes a modified Kornblum method and provides a simple alternative to the usual method for fabrication of the 1,2‐bis‐TSC ligands, which avoids the use of highly toxic selenium dioxide for oxidation of substituted acetophenones to 1,2 dicarbonyl compounds. The overall yields of the bis‐TSC chelates using this procedure were 8‐60%. The effects of the alkyl chain length and substitution on the C‐2 position on p‐carboxyalkylphenyl‐1,2‐diketo bis‐TSC bifunctional chelate for attaching radioisotopes of copper to proteins were studied. Following complexing copper‐64 or copper‐67 to the bis‐TSC chelate, the acid moiety of the TSC chelate was activated as the tetrafluorophenyl ester. The copper‐labeled activated TSC chelate was attached to bovine serum albumin under mild conditions in 3% to 40% yield. These studies have demonstrated that the shorter chain analogues of the TSC chelates from the 1,2‐diketones give the highest radiolabeling yields.
Characterization and developmental expression of chick aortic lysyl oxidase. (1992)

The complete primary structure of chick lysyl oxidase was determined by recombinant DNA techniques. The nucleotide sequence of contiguous chick lysyl oxidase cDNA clones contained an open reading frame of 1260 bases which encodes a predicted protein of 420 amino acid residues (48,150 Da). In comparison to the deduced primary structure of rat lysyl oxidase, the chick enzyme is larger in size and exhibits a strong conservation of sequence within the latter two thirds of the molecule (92% identity) and a high degree of divergence in the first 150 amino acid residues (60% identity allowing for several insertions in both sequences). The developmental steady-state levels of lysyl oxidase mRNA together with the mRNAs encoding two of the enzyme's substrates (tropoelastin and type I collagen) increased between 8 and 16 days of embryonic development. Although levels of lysyl oxidase mRNA increased during aortic embryogenesis, the specific activity of the enzyme remained fairly constant suggesting that lysyl oxidase activity increases in direct proportion to total protein synthesis and cell number. In situ hybridization showed that the spatial expressions of lysyl oxidase and tropoelastin transcripts differ suggesting that the enzyme and substrate genes are differentially regulated within the cells of the arterial wall.
Gamut Mapping Algorithms Based On Psychophysical Experiment (1997)

The aim of this paper is to describe five gamut mapping algorithms (GMAs) developed on the basis of the results from a psychophysical experiment evaluating eight previously published algorithms. What follows is a description of the colour reproduction system used, the new algorithms developed and the psychophysical experiments conducted for evaluating the new and existing GMAs.The experimental results suggest that the GCUSP and CARISMA algorithms described in this paper perform most reliably for the test images used in this experiment. Furthermore, the results show that four of the new algorithms perform significantly better than the two algorithms used in the previous experiment.
<i>Z</i>-Selective Metathesis Homocoupling of 1,3-Dienes by Molybdenum and Tungsten Monoaryloxide Pyrrolide (MAP) Complexes (2012)

Molybdenum or tungsten monoaryloxide pyrrolide (MAP) complexes that contain OHIPT as the aryloxide (hexaisopropylterphenoxide) are effective catalysts for homocoupling of simple (E)-1,3-dienes to give (E,Z,E)-trienes in high yield and with high Z selectivities. A vinylalkylidene MAP species was shown to have the expected syn structure in an X-ray study. MAP catalysts that contain OHMT (hexamethylterphenoxide) are relatively inefficient.
The Phusion Assembler (2002)

The Phusion assembler has assembled the mouse genome from the whole-genome shotgun (WGS) dataset collected by the Mouse Genome Sequencing Consortium, at ~7.5x sequence coverage, producing a high-quality draft assembly 2.6 gigabases in size, of which 90% of these bases are in 479 scaffolds. For the mouse genome, which is a large and repeat-rich genome, the input dataset was designed to include a high proportion of paired end sequences of various size selected inserts, from 2-200 kbp lengths, into various host vector templates. Phusion uses sequence data, called reads, and information about reads that share common templates, called read pairs, to drive the assembly of this large genome to highly accurate results. The preassembly stage, which clusters the reads into sensible groups, is a key element of the entire assembler, because it permits a simple approach to parallelization of the assembly stage, as each cluster can be treated independent of the others. In addition to the application of Phusion to the mouse genome, we will also present results from the WGS assembly of Caenorhabditis briggsae sequenced to about 11x coverage. The C. briggsae assembly was accessioned through EMBL, http://www.ebi.ac.uk/services/index.html, using the series CAAC01000001-CAAC01000578, however, the Phusion mouse assembly described here was not accessioned. The mouse data was generated by the Mouse Genome Sequencing Consortium. The C. briggsae sequence was generated at The Wellcome Trust Sanger Institute and the Genome Sequencing Center, Washington University School of Medicine.
Azelastine nasal spray in the management of seasonal allergic rhinitis. (1994)

Azelastine is a novel, investigational, antiallergy medication that inhibits the generation, release, and/or end-organ activity of multiple mediators of the inflammatory process in vitro and in vivo. Azelastine is capable of inhibiting both early-phase and late-phase allergic responses in animals and humans. In this 2-day trial in patients with seasonal allergic rhinitis, we evaluated the onset of action, duration of effect, and safety and efficacy of azelastine nasal solution (Astelin N.S.) in an outdoor, highly allergenic environment. Two hundred ninety-four patients who satisfied entry criteria were randomized to azelastine 2 sprays/nostril q24h or q12h, oral chlorpheniramine maleate 12 mg q12h, or placebo in this multicenter, double-blind, parallel-group study. Rhinitis symptoms were analyzed individually and combined as total and major symptom complexes. For both azelastine treatment groups, the overall mean percent improvements in the total and major symptom complex severity scores were statistically significant (P < or = .05) versus placebo. Improvements in rhinitis symptoms were observed by the second hour after administration of azelastine and lasted up to 24 hours. The therapeutic effect of azelastine was apparent for all rhinitis symptoms, not just one or a few symptoms. Seventy-three percent of the patients treated with azelastine reported overall improvement upon global assessment of their symptoms. Adverse effects with azelastine were generally mild or moderate. Azelastine nasal spray, administered either once or twice daily, was effective in treating the symptoms of seasonal allergic rhinitis and demonstrated a rapid onset of action with a duration of response lasting 12 to 24 hours.
Algorithms and estimators for accurate summarization of internet traffic (2007)

Statistical summaries of traffic in IP networks are at the heart of network operation and are used to recover information on the traffic of arbitrary subpopulations of flows. It is therefore of great importance to collect the most accurate and informative summaries given the router's resource constraints. Cisco's sampled NetFlow, based on aggregating a sampled packet stream into flows, is the most widely deployed such system.
Xanthones from the Green Fruit Hulls of<i>Garcinia</i><i>m</i><i>angostana</i> (2002)

Three new xanthones, mangostenol (1), mangostenone A (2), and mangostenone B (3), were isolated from the green fruit hulls of Garcinia mangostana, along with the known xanthones, trapezifolixanthone, tovophyllin B (4), alpha- and beta-mangostins, garcinone B, mangostinone, mangostanol, and the flavonoid epicatechin. The structures of the new xanthones were elucidated by analysis of their spectroscopic data.
Fine grain parallel communication on general purpose LANs (1996)

workstations connected by commodity networks are increasingly viewed as an economically viable alternative to tightly coupled multiprocessors.
Comparison of Commonly Used Image Interpolation Methods (2013)

Image magnification algorithms directly affect the quality of image magnification. In this paper, based on the image interpolation algorithm principle, features of the nearest neighbor interpolation, bilinear interpolation, bicubic interpolation and cubic B spline interpolation were analyzed. At the same time, their advantages and disadvantages were compared. In the experiment, image magnification performance of different interpolation algorithms was compared from subjective and objective aspects. The experimental results give the guidance for the user to choose a suitable algorithm to achieve optimum results according to different application.
BASIC AND CLINICAL STUDIES OF LOCAL HYPERTHERMIA FOR PROSTATIC CANCER (1992)

The effect of local hyperthermia on the prostate using 13.56 MHz radio frequency wave (RF wave) was reported. Firstly, temperature and blood flow of the prostate in normal dogs were measured during local hyperthermia. In most part of the prostate, the temperature reached over 42 degrees C, which was considered as favorable for the hyperthermia therapy. Blood flow of the prostatic tissue rose more slowly than that of muscle tissue. Secondly, the tissue concentration of anticancer agents after local hyperthermia was measured. There was a tendency that drug concentration in the prostate tissue after local hyperthermia was higher than that without local hyperthermia. Histological findings showed interstitial edema and congestion. As a clinical trial, 14 cases of prostatic cancer were treated with local hyperthermia after the administration of anticancer agents. Seven of them were fresh cases and the others were relapsed cases. After treatment, tumor size was reduced in 13 cases. According to "The Response Criteria for Urologic Tumor", one Complete Response, 3 Partial Response and 10 No Change cases were obtained. There was no tumor progression. As for side effects, bone marrow suppression, loss of appetite, diarrhea and skin burns were noted. However, these side effects were mild, and did not interrupt the treatment. Local hyperthermia of the prostate after systemic chemotherapy could be carried out safely and effectively in patients with prostatic cancer.
Intelligent Oven in Smart Home Environment (2009)

Smart homes are gradually becoming one of the main applications in the high technology area. The intelligent appliance is a fundamental component of a smart home environment. People tend to invest in the kitchen appliances as they will be used throughout their lifetime, therefore many manufacturers focus on making these appliance more interesting. However, majority of manufacturers focus on how to make them cook faster. Very few manufacturers pay attention on the ability to cook healthier food. In this paper we introduce an innovative intelligent oven for the healthier food choice that is woven inside smart home environment. The intelligent oven is designed for manipulating recommended healthy recipe choices to suit each family member health concerns. Moreover, its ability to interact with other smart appliances such as smart fridge, mobile phone, and smart fire alarm are beneficial. We believe that the features mentioned above will make the intelligent oven an essential component in the smart home environment.
The effects of altering mean pressure, pulse pressure and pulse frequency on the impulse activity in baroreceptor fibres from the aortic arch and right subclavian artery in the rabbit (1971)

1. A method is described for perfusing an isolated preparation of the rabbit aortic arch with independently controlled mean pressure, pulse pressure and pulse frequency.2. Recordings made from single or few-fibre preparations from the aortic arch and right subclavian baroreceptor regions show that the number of impulses per second or per cycle in a single fibre is the same during pulsatile perfusion as during non-pulsatile perfusion if the pressure is above the threshold pressure to non-pulsatile perfusion during all phases of the pressure cycle.3. In multi-fibre recordings the total number of impulses is greater during pulsatile perfusion than during non-pulsatile perfusion due largely to recruitment of fibres during systole.4. The relationship between instantaneous impulse frequency and aortic arch pressure during one pressure cycle forms an elliptiform curve.5. Increasing the pulse pressure increases the ellipse and causes additional recruitment of other fibres during systole, thus augmenting the total impulse activity.6. Increasing the pulse frequency reduces the number of impulses per cycle for single fibres but produces a small increase in the total impulse frequency in one second period due to recruitment.7. Increasing the rate of change of pressure by increasing the pulse pressure or pulse frequency produced a small reduction or no change of the threshold pressure. Similarly the ;cut off' pressure was elevated in some fibres.8. At low initial mean pressures, an increment of pressure, at constant pulse pressure and pulse frequency, increases the total impulse activity by increasing the frequency of impulses in single fibres already active during systole and diastole and by additional recruitment of other fibres. At higher mean pressures there is little increase in impulse activity as the maximum frequency of fibres is attained or superseded and there is little recruitment.
Kinetic studies on the formation of various II–VI semiconductor nanocrystals and synthesis of gradient alloy quantum dots emitting in the entire visible range (2012)

From kinetic experiments monitoring the consumption of chalcogenide precursors by 31P NMR, it could be concluded that the formation rates of metal chalcogenides (M–E, M = Cd or Zn and E = Se or S) were in the order of ZnS < ZnSe < CdS < CdSe when one equivalent of metal oleate (M–OA) precursor reacted with one equivalent of trioctylphosphine chalcogenide (TOP–E) precursor. On the basis of the reactivity differences, various amounts of each precursor molecule could be deliberately chosen to tune the structure of the generated QDs and consequently the emission colors in the entire visible range. The excellent photochemical stability of the gradient alloy QDs could provide evidence that a good overall coverage of the shell on the core part significantly reduced defects due to lattice mismatch.
GFAP-BDP as an Acute Diagnostic Marker in Traumatic Brain Injury: Results from the Prospective Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study (2013)

Reliable diagnosis of traumatic brain injury (TBI) is a major public health need. Glial fibrillary acidic protein (GFAP) is expressed in the central nervous system, and breakdown products (GFAP-BDP) are released following parenchymal brain injury. Here, we evaluate the diagnostic accuracy of elevated levels of plasma GFAP-BDP in TBI. Participants were identified as part of the prospective Transforming Research And Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Study. Acute plasma samples (<24 h post-injury) were collected from patients presenting with brain injury who had CT imaging. The ability of GFAP-BDP level to discriminate patients with demonstrable traumatic lesions on CT, and with failure to return to pre-injury baseline at 6 months, was evaluated by the area under the receiver operating characteristic curve (AUC). Of the 215 patients included for analysis, 83% had mild, 4% had moderate, and 13% had severe TBI; 54% had acute traumatic lesions on CT. The ability of GFAP-BDP level to discriminate patients with traumatic lesions on CT as evaluated by AUC was 0.88 (95% confidence interval [CI], 0.84-0.93). The optimal cutoff of 0.68 ng/mL for plasma GFAP-BDP level was associated with a 21.61 odds ratio for traumatic findings on head CT. Discriminatory ability of unfavorable 6 month outcome was lower, AUC 0.65 (95% CI, 0.55-0.74), with a 2.07 odds ratio. GFAP-BDP levels reliably distinguish the presence and severity of CT scan findings in TBI patients. Although these findings confirm and extend prior studies, a larger prospective trial is still needed to validate the use of GFAP-BDP as a routine diagnostic biomarker for patient care and clinical research. The term "mild" continues to be a misnomer for this patient population, and underscores the need for evolving classification strategies for TBI targeted therapy. (ClinicalTrials.gov number NCT01565551; NIH Grant 1RC2 NS069409).
Controlled Design of Size-Tunable Monodisperse Nickel Nanoparticles (2010)

We present here a complete study on a synthesis of nickel nanoparticles involving the reaction of [Ni(acac)2] with oleylamine (OA) and trioctylphosphine (TOP) reactants, whose simultaneous presence and relative amounts are paramount. The role of every reactant in the nucleation and growth of the nanoparticles has been delineated: OA is the reductant and thus controls the nucleation rate, meanwhile TOP provides a tunable surface stabilization through coordination on the Ni(0) surface. This result leads us to a design synthesis providing tailored monodispersed nanoparticles in a wide range (2−30 nm), which allows self-consistent studies of size-induced changes in catalytic and magnetic properties. Additionally, the growth mechanism is demonstrated to include an aggregation step which thus correlates with the polycrystalline feature of the nanoparticles obtained through this process. Moreover, the critical influence of the phosphine in this system was demonstrated a) for the outcome of the ripening mechanisms: defocusing effect and/or reshaping of the particles and b) for the surface properties: binding of the phosphine to the surface and its behavior toward oxidation was investigated by FTIR. Preliminary SQUID measurements show the impact of crystallites size on the magnetic properties.
Das Bioisosterie‐Konzept: Arzneistoffentwicklung (2004)

Abstract Bioisosterie bedeutet gleiche räumliche Ausdehnung bei vergleichbarer Wirkung in biologischen Systemen. Dies bezieht sich auf pharmakologisch wirksame Verbindungen, die vor allem in vivo einen vergleichbaren Effekt erzielen. Die Paare Benzol‐Thiophen, Benzol‐Pyridin und Thiophen‐Furan sind bekannte Beispiele für Bioisosterie in der Wirkstoffforschung.
Molecular fluorescence measurements with a charge-coupled device detector (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular fluorescence measurements with a charge-coupled device detectorPatrick M. Epperson, Rafi D. Jalkian, and M. Bonner. DentonCite this: Anal. Chem. 1989, 61, 3, 282–285Publication Date (Print):February 1, 1989Publication History Published online1 May 2002Published inissue 1 February 1989https://pubs.acs.org/doi/10.1021/ac00178a020https://doi.org/10.1021/ac00178a020research-articleACS PublicationsRequest reuse permissionsArticle Views139Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Is a bot at the controls? (2007)

The use of programmatically generated input data in place of human-generated input data poses problems for many computer applications in use today. Mouse clicks and keyboard strokes can automatically be generated to cheat in online games, or to perpetrate click fraud. The ability to discern whether input data was computationally generated instead of created by a human input device is therefore of paramount importance to these types of applications. This paper describes a method for detecting input data that was computationally modified or fabricated. This includes detecting data that was not directly generated by a physical human input device such as a keyboard or mouse. A prototype of this system was built on existing hardware and was shown to be effective at detecting attacks on a real application. This detection method is capable of addressing the majority of input-based attacks currently in use. When used in conjunction with a trusted peripheral, it offers a robust mechanism for ensuring a computer is not at the controls.
A multicenter numerical integration scheme for polyatomic molecules (1988)

We propose a simple scheme for decomposition of molecular functions into single-center components. The problem of three-dimensional integration in molecular systems thus reduces to a sum of one-center, atomic-like integrations which are treated using standard numerical techniques in spherical polar coordinates. The resulting method is tested on representative diatomic and polyatomic systems for which we obtain five- or six-figure accuracy using a few thousand integration points per atom.
Lighthouse: showing the way to relevant information (2002)

Lighthouse is an on-line interface for a Web-based information retrieval system. It accepts queries from a user, collects the retrieved documents from the search engine, organizes and presents them to the user. The system integrates two known presentations of the retrieved results, the ranked list and clustering visualization, in a novel and effective way. It accepts the user's input and adjusts the document visualization accordingly. We give a brief overview of the system.