gebhart/patrepeval huggingface dataset:
Surface Ig on B lymphocytes from cattle and sheep (1997)

IgD, first demonstrated in humans, has been unequivocally shown to exist in primates and rodents. In addition to IgM a second unique membrane isotype, generally considered to be IgD, has been demonstrated in a number of other species, including dogs and chickens. Because of its assumed widespread presence, it is widely accepted that IgD is phylogenetically conserved and therefore functionally important in B cell maturation. In the present paper, we could not demonstrate IgD on bovine B cells derived from peripheral blood, lymph nodes, spleen and fetal spleen by precipitation with anti-light chain antibodies. This lack of detectable IgD was confirmed in peripheral blood B cells of sheep, and raises questions on the requirement for IgD in cell differentiation and Ig secretion. At present it is not clear whether cattle (and sheep) are an exception in this context. Reports of the presence of IgD in different species are largely based on the assumption that non-IgM surface Ig is most likely IgD. Our data question this extrapolation and stress the need for further isotype characterization of the surface Ig in different species. Lack of surface IgD has been observed in human and mouse B-1 cells, most of which express the surface marker CD5. The possibility that all bovine B cells belong to the B-1 lineage is discussed.
Different Mechanisms of Oxidative Stress and Neurotoxicity for Alzheimer‘s Aβ(1−42) and Aβ(25−35) (2001)

Oxidative stress induced by amyloid beta-peptide (A beta) has been implicated in the neurodegeneration observed in Alzheimer's disease (AD) brain. However, the mechanism by which the predominant form of A beta found in AD brains, A beta(1--42), causes oxidative stress and neurotoxicity remains unknown. Numerous laboratories have used the smaller 11-amino acid fragment of the full-length peptide, A beta(25--35), as a convenient alternative in AD investigations since the smaller peptide mimics several of the toxicological and oxidative stress properties of the native full-length peptide. Our observation that the truncated peptide is more rapidly toxic and causes more oxidative damage than the parent A beta(1--42) led us to investigate the cause for this enhanced toxicity of A beta(25--35) in order to gain insight into the mechanism of action of these peptides. These studies reveal that two different mechanisms may be operative in the two peptides; however, the single methionine residue in the peptides appears to play a crucial role in both mechanisms. That methionine is C-terminal in A beta(25--35) seems to be the cause for its exaggerated effects. When the next amino acid in the sequence of A beta(1--42) (valine) is appended to A beta(25--35), the resultant peptide, A beta(25--36), in which methionine is no longer C-terminal, is neither toxic to cultured neurons nor does it cause oxidative damage. Additionally, oxidizing the sulfur of methionine to a sulfoxide abrogates the damaging effects of both A beta(25--35) and A beta(1--42). The putative mechanistic role of methionine in the observed properties of A beta peptides is discussed in the context of the obtained results as is the role of A beta(1--42)-induced oxidative stress in the neurodegeneration found in AD brain.
Unity in Transposition Reactions (1995)

Cells and viruses use transposition reactions under several circumstances to move pieces of DNA around the genome. N. Craig argues that all of these events occur by similar breakage and joining reactions and that transposition proteins are quite similar structurally, in spite of a lack of substantial sequence homology.
Role of Exopolysaccharides in Pseudomonas aeruginosa Biofilm Formation and Architecture (2011)

Pseudomonas aeruginosa is an opportunistic human pathogen and has been established as a model organism to study bacterial biofilm formation. At least three exopolysaccharides (alginate, Psl, and Pel) contribute to the formation of biofilms in this organism. Here mutants deficient in the production of one or more of these polysaccharides were generated to investigate how these polymers interactively contribute to biofilm formation. Confocal laser scanning microscopy of biofilms formed in flow chambers showed that mutants deficient in alginate biosynthesis developed biofilms with a decreased proportion of viable cells than alginate-producing strains, indicating a role of alginate in viability of cells in biofilms. Alginate-deficient mutants showed enhanced extracellular DNA (eDNA)-containing surface structures impacting the biofilm architecture. PAO1 ΔpslA Δalg8 overproduced Pel, and eDNA showing meshwork-like structures presumably based on an interaction between both polymers were observed. The formation of characteristic mushroom-like structures required both Psl and alginate, whereas Pel appeared to play a role in biofilm cell density and/or the compactness of the biofilm. Mutants producing only alginate, i.e., mutants deficient in both Psl and Pel production, lost their ability to form biofilms. A lack of Psl enhanced the production of Pel, and the absence of Pel enhanced the production of alginate. The function of Psl in attachment was independent of alginate and Pel. A 30% decrease in Psl promoter activity in the alginate-overproducing MucA-negative mutant PDO300 suggested inverse regulation of both biosynthesis operons. Overall, this study demonstrated that the various exopolysaccharides and eDNA interactively contribute to the biofilm architecture of P. aeruginosa.
Beam shaping by holographic filters (1989)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Nicholas C. Roberts, "Beam shaping by holographic filters," Appl. Opt. 28, 31-32 (1989) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats (2013)

FXR agonist INT-747 improves PHT in two different rat models of cirrhosis by decreasing IHVR. This hemodynamic effect relates to increased intrahepatic eNOS activity by pathways that differ depending on the etiology of cirrhosis.
Leukocyte density and volume in normal subjects and in patients with acute lymphoblastic leukemia (1976)

A method is described for the separation of blood and bone marrow leukocytes on the basis of buoyant density, using a discontinuous Ficoll-Hypaque density gradient. The median cell densities of monocytes and lymphocytes were found to be 1.067-1.077 and 1.073-1.077 g/ml, respectively. The cells of the myeloid series were shown to increase in density with maturation; the myeloblasts had the lowest density (1.064-1.065 g/ml) and the neutrophils the highest (greater than 1.080 g/ml). Cell volumes have been determined on isolated cell populations. The findings were: monocytes, 534 +/- 47 cu mu; lymphocytes, 247 +/- 18 cu mu; and neutrophils, 468 +/- 24 cu mu. Fourteen patients with acute lymphoblastic leukemia were studied. In four patients, the lymphoblasts were of low density (less than 1.068 g/ml), whereas the remaining patients had high density (greater than 1.068 g/ml) lymphoblasts. These four patients had large numbers of lymphoblasts in the peripheral blood and a poor prognosis. Lymphoblast volumes were not different in these two groups and were unrelated to prognosis.
A wide band transhorizon experiment at 11.6 GHz (1993)

The authors give an overview of a wide band experiment at 11.6 GHz designed to analyze and model a transhorizon communications channel subject to both scattering and anomalous propagation conditions. The salient features of the measurement equipment and the associated signal processing techniques are described. The approach to remote sensing the propagation path is outlined and combines ray extraction and trajectory tracing. >
Making Convolutional Networks Shift-Invariant Again (2019)

Modern convolutional networks are not shift-invariant, as small input shifts or translations can cause drastic changes in the output. Commonly used downsampling methods, such as max-pooling, strided-convolution, and average-pooling, ignore the sampling theorem. The well-known signal processing fix is anti-aliasing by low-pass filtering before downsampling. However, simply inserting this module into deep networks degrades performance; as a result, it is seldomly used today. We show that when integrated correctly, it is compatible with existing architectural components, such as max-pooling and strided-convolution. We observe \textit{increased accuracy} in ImageNet classification, across several commonly-used architectures, such as ResNet, DenseNet, and MobileNet, indicating effective regularization. Furthermore, we observe \textit{better generalization}, in terms of stability and robustness to input corruptions. Our results demonstrate that this classical signal processing technique has been undeservingly overlooked in modern deep networks. Code and anti-aliased versions of popular networks are available at https://richzhang.github.io/antialiased-cnns/ .
Industrial RB211 DLE Gas Turbine Combustion Update (2000)

Industrial gas turbines have universally had problems with combustion amplified pressure oscillations (combustion instability or noise) in premix lean burn combustors. Reference 1 issued by General Electric is a particularly good report. Under specific conditions a resonant frequency achieves sufficient amplitude to cause severe damage to the combustor. As the emissions are reduced to lower levels, by achieving better uniformity of fuel and air distribution and a larger percentage of the air is used in the combustion process, then these amplitudes have the potential to become greater especially at high pressure ratios. Small changes in either ambient conditions or fuel quality appear to cause noise amplitudes to become unacceptable.
Is There Additional Information from Laparoscopic Ultrasound in Tumor Staging? (2002)

Accurate preoperative staging of gastrointestinal malignancies is of major importance in the decision for adequate stage-related therapy. There is evidence that laparoscopy in combination with laparoscopic ultrasound is more accurate in the detection of intra-abdominal metastases than conventional preoperative imaging. Staging laparoscopy in combination with laparoscopic ultrasound is a minimally invasive technique that reveals intra-abdominal disseminated tumor spread and local tumor extent. Therefore laparoscopic ultrasound is an ideal adjunct to laparoscopy because this technique may compensate for the lack of tactile feedback with laparoscopic instruments. Color-coded Doppler imaging can be very valuable for the assessment of resectability in patients with pancreatic cancer. Current data confirm that laparoscopic ultrasound is capable of enhancing the accuracy of staging laparoscopy. Compared to standard laparoscopy, a combination of both techniques markedly increases the sensitivity of staging laparoscopy in the determination of unresectable disease. This is of major importance in the assessment of occult liver metastases and lymph node involvement. Laparoscopic ultrasonography improves the diagnostic accuracy compared to conventional imaging techniques and should be considered as integral part of staging laparoscopy.
ChemInform Abstract: Virtual Screening—An Overview (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Experimental Rotator Cuff Repair. A Preliminary Study* (1999)

Different techniques for rotator cuff repair substantially influence the rate of failure. A modified Mason-Allen stitch does not cause tendon necrosis, and use of this stitch with cortical-bone augmentation yields a repair that is biologically well tolerated and stronger in vivo than a repair with the conventional technique. Unprotected repairs, however, have an exceedingly high rate of failure even if optimum repair technique is used. Postoperative protection from tension overload, such as with an abduction splint, may be necessary for successful healing of massive rotator cuff tears.
Easy and Efficient SNAr Reactions on Halopyridines in Solvent Free Conditions (1991)

Solid-liquid phase transfer catalysis (PTC) without added solvent efficiently promotes S N Ar reactions on halopyridines with a variety of anionic nucleophiles generated in situ. This methodology gives access to substituted pyridines in very simplified conditions depending on halide nature. Mechanistic investigations are proposed
Dopant Incorporation in Ceria for Enhanced Water-Splitting Activity during Solar Thermochemical Hydrogen Generation (2012)

Ceria has emerged as an attractive candidate for solar thermochemical hydrogen production; however, the necessary temperatures for CeO2 reduction to Ce2O3 are too high for conventional solar concentrating systems, while the reduction to nonstoichiometric CeO2−δ below 1500 °C shows restricted chemical yield. Doping ceria with another metal can improve the reactivity at lower temperatures. This study focuses on the doping of ceria with different metals such as tantalum or trivalent lanthanides (La, Sm, and Gd) to form binary oxides and on the doping of ceria–zirconia solid solutions to form ternary oxides. Ceria materials doped with tantalum show a high reducibility, but the structural evolution during thermal treatment leads to the formation of a secondary phase that hinders the water dissociation reaction. Besides, the doping with trivalent lanthanides results in an improved thermal stability during consecutive cycles, while the hydrogen production is unchanged compared to ceria. Concerning ternary oxides, the addition of 1% gadolinium to ceria–zirconia solid solutions results in the production of 338.2 μmol (7.58 mL) of hydrogen per gram during one cycle with the O2-releasing step at 1400 °C and the H2-generation step at 1050 °C. This production is higher than the one observed for undoped ceria–zirconia. The addition of lanthanum enhances the thermal stability of ceria–zirconia solid solution, thus leading to stable reactivity during repeated cycles.
Feeder Reconfiguration in Distribution Networks Based on Convex Relaxation of OPF (2014)

The feeder reconfiguration problem chooses the on/off status of the switches in a distribution network in order to minimize a certain cost such as power loss. It is a mixed-integer nonlinear program and, hence, hard to solve. In this paper, we propose a heuristic algorithm that is based on the recently developed convex relaxation of the ac optimal power flow problem. The algorithm is computationally efficient and scales linearly with the number of redundant lines. It requires neither parameter tuning nor initialization for different networks. It successfully computes an optimal configuration on all four networks we have tested. Moreover, we have proved that the algorithm solves the feeder reconfiguration problem optimally under certain conditions for the case where only a single redundant line needs to be opened. We also propose a more computationally efficient algorithm and show that it incurs a loss in optimality of less than 3% on the four test networks.
Application of Atomic Force Microscopy to Visualization of DNA, Chromatin, and Chromosomes (1997)

The scanning force microscope (SFM, also called the atomic force microscope, AFM) provides a new and powerful method for visualization and manipulation of biological samples. Its high precision and sensitivity allow the investigator to interrogate samples at very high spatial resolution and simultaneously accumulate a variety of data types, including topography, viscoelasticity, chemical properties, and local friction. We provide here a brief review of the literature describing the current state of the art in the application of SFM to the study of DNA, chromatin and chromosomes, and some examples from this laboratory. Suggestions for future directions of this technology are also presented.
Dynamic-vector execution on a general purpose EDGE chip multiprocessor (2014)

This paper proposes a cost-effective technique that morphs the available cores of a low power chip multiprocessor (CMP) into an accelerator for data parallel (DLP) workloads. Instead of adding a special-purpose vector architecture as an accelerator, our technique leverages the resources of each CMP core to mimic the functionality of a vector processor. The morphing provides dynamic vector execution (DVX) on a general purpose CMP, by adding minimal hardware for vector control. DVX enhances the vector execution by dynamically configuring the allocation of compute and memory resources to match particular workload requirements. As an energy efficient substrate, we utilize modest dual issue cores based on an Explicit Data Graph Execution (EDGE) architecture. The results show that a DVX enabled 4-core EDGE CMP improves the energy-delay product over 14x, at the cost of only 1.1% of additional area. We compare DVX against a CMP that adds a dedicated DLP accelerator based on a conventional high performance vector design. The vector accelerator increases the area footprint over 74%, which greatly affects the cost of the modest processor. DVX avoids the additional costs and yet gains over 86% of the speedup obtained with the dedicated accelerator.
Coulomb blockade in strained-Si nanowires on leaky virtual substrates (2001)

Nanowires fabricated from a modulation-doped Si/Si0.7Ge0.3 heterostructure grown on a virtual substrate can exhibit Coulomb blockade due to single-electron charging of multiple islands. A non-blockaded behaviour in some wires is attributed to a combination of incomplete tunnel barrier formation and leakage currents. The leakage manifests itself in the form of a B2 dependence in magnetoresistance measurements. It is found that the leakage arises mainly from the substrate. In some narrow nanowires at very low temperatures, the leakage is negligible and electronic transport along the wires can be explained using the classical Coulomb blockade theory. It is believed that threading dislocations are responsible for the formation of Coulomb islands in the wires. The islands' sizes and the number of tunnel barriers separating the islands agree well with the geometrical dimensions of the fabricated wires.
Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP<sub>3</sub> Receptor Antagonists (2010)

High-throughput screening and subsequent optimization led to the discovery of novel 3-oxazolidinedione-6-aryl-pyridinones exemplified by compound 2 as potent and selective EP3 antagonists with excellent pharmacokinetic properties. Compound 2 was orally active and showed robust in vivo activities in overactive bladder models. To address potential bioactivation liabilities of compound 2, further optimization resulted in compounds 9 and 10, which maintained excellent potency, selectivity, and pharmacokinetic properties and showed no bioactivation liability in glutathione trapping studies. These highly potent, selective, and orally active EP3 antagonists are excellent tool compounds for investigating and validating potential therapeutic benefits from selectively inhibiting the EP3 receptor.
SAM2 encodes the second methionine S-adenosyl transferase in Saccharomyces cerevisiae: physiology and regulation of both enzymes. (1988)

In Saccharomyces cerevisiae the SAM1 and SAM2 genes encode two distinct forms of S-adenosylmethionine (AdoMet) synthetase. In a previous study we cloned and sequenced the SAM1 gene (D. Thomas and Y. Surdin-Kerjan, J. Biol. Chem. 262:16704-16709, 1987). In this work, the SAM2 gene was isolated by functional complementation of a yeast double-mutant strain, and its identity was ascertained by gene disruption. It has been sequenced and compared with the SAM1 gene. The degree of homology found between the two genes shows that SAM1 and SAM2 are duplicated genes. Using strains disrupted in one or the other SAM gene, we have studied the regulation of their expression by measuring the steady-state level of mRNA after growth under different conditions. The results show that the expression of the two SAM genes is regulated differently, SAM2 being induced by the presence of excess methionine in the growth medium and SAM1 being repressed under the same conditions. The level of mRNA in the parental strain shows that it is not the sum of the levels found in the two disrupted strains. This raises the question of how the two AdoMet synthetases in S. cerevisiae interact to control AdoMet synthesis.
Factors responsible for ADP-induced release reaction of human platelets (1975)

Extensive aggregation of human platelets can be induced by ADP without secondaryaggregation or release of granule contents. This occurs with washed platelets in Tyrode solution containing 0.35% albumin, human fibrinogen, and apyrase, and in platelet-rich, heparin- or hirudin-plasma. Conditions that caused release during ADP-inducedaggregation were-citrate as the anticoagulant in platelet-rich plasma; addition of citrate (11-15 mM) to a suspension of washed platelets, or to hirudin-plasma or heparin-plasma; suspension of platelets in a medium containing magnesium but no calcium;and the presence of trace amounts of thrombin or aggregated gamma globulin in the platelet suspensions. Acetylsalicylic acid, phenylbutazone, or sulfinpyrazone inhibited secondary aggregation and release in all these circumstances. Heparin or hirudin inhibited ADP-INDUCED SECONDARY AGGREGATION AND RELEASE PROMOTED BY TRACES OF THROMBIN. Although fibrinogen is required for ADP-induced primary aggregation, it does not support secondary aggregation and release, provided that it has no clot-promoting activity. The main agent responsible for ADP-induced secondary aggregation and release in human, citrated, platelet-rich plasma appears to be sodium citrate. Suspending washed human platelets in a medium without calcium mimics the effect of citrate.