gebhart/patrepeval huggingface dataset:
The Hydrogenation of Lupulone and Humulone (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Hydrogenation of Lupulone and HumuloneJ. F. CarsonCite this: J. Am. Chem. Soc. 1951, 73, 4, 1850–1851Publication Date (Print):April 1, 1951Publication History Published online1 May 2002Published inissue 1 April 1951https://pubs.acs.org/doi/10.1021/ja01148a512https://doi.org/10.1021/ja01148a512research-articleACS PublicationsRequest reuse permissionsArticle Views205Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optical low coherence method for characterizing silica-based arrayed-waveguide grating multiplexers (1996)

We describe a powerful method for the precise measurement of optical path phase errors and power-distribution coefficients in silica-based arrayed-waveguide grating multiplexers through the use of Fourier transform spectroscopy. The theoretical accuracies for measuring these parameters are /spl plusmn/1/spl deg/ and /spl plusmn/5%, respectively, when the geometrical step increment of the arrayed waveguides is greater than 48 /spl mu/m. The method reveals the random distributions of optical path phase errors in two multiplexers with channel spacings of 100 and 10 GHz, and proves that these distributions are the main origins of the channel crosstalk. The method predicts that when optical path phase errors are sufficiently reduced, the channel crosstalk values will decrease to -39 and -29 dB, respectively, and these limits are due to slightly deformed power distributions.
Anterior Sphincteroplasty for Fecal Incontinence: A Single Center Experience in the Era of Sacral Neuromodulation (2009)

Anterior sphincteroplasty results in an acceptable to excellent long-term outcome in 60% of patients, especially in those under the age of 50 years at surgery.
A Fully Integrated V-Band PLL MMIC Using 0.15-&lt;tex&gt;$muhbox m$&lt;/tex&gt;GaAs pHEMT Technology (2006)

A fully integrated V-band phase-locked loop (PLL) MMIC with good phase noise and low-power consumption is developed using 0.15-/spl mu/m GaAs pHEMTs. For V-band frequency division,a wideband divide-by-3 frequency divider is proposed using cascode FET-based harmonic injection locking. The fourth subharmonic mixer using anti-parallel diode pair is employed as a high-frequency phase detector. In this way, the required frequency of the reference oscillator is lowered to one twelfth of V-band output signal. An RC low-pass filter and DC amplifier are also integrated to effectively suppress the spurious and harmonic signals, and to increase the loop gain. To reduce the circuit interactions and frequency pulling effect, buffer amplifiers are used at the output of VCO and frequency divider. The fabricated V-band PLL MMIC shows the locking range of 840 MHz around 60.1GHz under a very low power dissipation of 370 mW. Good phase noise of -95.5 dBc/Hz is measured at 100 kHz offset. The chip size is as small as 2.35/spl times/1.80 mm/sup 2/. To the best of our knowledge, the PLL MMIC of this work is one of the highest frequency monolithic PLLs that integrates all the required elements on a single chip.
Design and construction of an active alignment demonstrator for a free-space optical interconnect (1995)

An x-y active alignment system based on Risley beam steerers is described. The demonstrator features a quadrant detector which detects the misalignment error between the center of a spot of light and the center of the quadrant detector. This misalignment error is then used by a new algorithm to calculate the rotational displacement required for the two Risley beam steerers to steer the spot of light to the center of the quadrant detector. The experimental results indicate that any spot misaligned by up to 160 μm on the quadrant detector will be systematically centered by the demonstrator system.
Granulomatous rosacea and Crohn’s disease in a patient homozygous for the Crohn‐associated NOD2/CARD15 polymorphism R702W (2008)

NOD2/CARD15 belongs to the N-terminal caspase recruitment domain family of proteins involved in regulating NF-kB activation in response to inflammatory stimuli transduced through Toll-like receptors. Mutations and polymorphisms in the NOD2/CARD15 gene reduce antibacterial responses and are associated with granulomatous inflammatory conditions such as Blau syndrome and early-onset sarcoidosis. The polymorphism R702W (arginine to tryptophan) is strongly associated with susceptibility to Crohn's disease in Caucasian populations. Skin abnormalities (other than cutaneous manifestations of Crohn's disease) have not been previously associated with R702W. We report on a female patient homozygous for R702W who developed granulomatous rosacea at the age of 12 years old. From the occurrence in the context of Crohn associated with R702W, we speculate that granulomatous rosacea may be an entity distinct from other forms of rosacea, which are associated with increased production of antibacterial proteins such as cathelicidin.
A gate resizing technique for high reduction in power consumption (1997)

Article Free Access Share on A gate resizing technique for high reduction in power consumption Authors: P. Girard Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier, UMR 5506 Universite Montpellier II/CNRS, 161 rue Ada, 34392 Montpellier Cedex 05, France Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier, UMR 5506 Universite Montpellier II/CNRS, 161 rue Ada, 34392 Montpellier Cedex 05, FranceView Profile , C. Landrault Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier, UMR 5506 Universite Montpellier II/CNRS, 161 rue Ada, 34392 Montpellier Cedex 05, France Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier, UMR 5506 Universite Montpellier II/CNRS, 161 rue Ada, 34392 Montpellier Cedex 05, FranceView Profile , S. Pravossoudovitch Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier, UMR 5506 Universite Montpellier II/CNRS, 161 rue Ada, 34392 Montpellier Cedex 05, France Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier, UMR 5506 Universite Montpellier II/CNRS, 161 rue Ada, 34392 Montpellier Cedex 05, FranceView Profile , D. Severac Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier, UMR 5506 Universite Montpellier II/CNRS, 161 rue Ada, 34392 Montpellier Cedex 05, France Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier, UMR 5506 Universite Montpellier II/CNRS, 161 rue Ada, 34392 Montpellier Cedex 05, FranceView Profile Authors Info & Claims ISLPED '97: Proceedings of the 1997 international symposium on Low power electronics and designAugust 1997 Pages 281–286https://doi.org/10.1145/263272.263352Online:01 August 1997Publication History 21citation300DownloadsMetricsTotal Citations21Total Downloads300Last 12 Months4Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice. (2003)

Treatment of H-Ras transgenic mice with the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-2154 results not only in halting the growth of aggressive breast tumors but actually in inducing the regression (54 +/- 3%) of all 19 tumors analyzed. The farnesyltransferase (FTase) inhibitor FTI-2148 induced an average of 87 +/- 3% regression in the 13 tumors analyzed. GGTase I, but not FTase, is inhibited in breast tumors after treatment with GGTI-2154, whereas in tumors from mice treated with FTI-2148, only FTase is inhibited. The processing of the geranylgeranylated proteins RhoA, Rap1, and R-Ras, but not the farnesylated proteins H-Ras and HDJ-2, is inhibited in tumors obtained from mice treated with GGTI-2154. GGTI-2154 and FTI-2148 suppress constitutively activated phospho-Erk1/2 and phospho-Akt, induce apoptosis, and induce differentiation toward ductolobular breast epithelium. The data demonstrate that geranylgeranylated proteins are critical in H-Ras oncogenesis in vivo and give strong support for GGTase I as a target for anticancer drug discovery.
Tumour necrosis factor‐α receptor 1 and 2 polymorphisms in inflammatory bowel disease and their association with response to infliximab (2004)

The TNFR2 587G allele was more frequent in ulcerative colitis. Both single nucleotide polymorphisms were negatively associated with smoking in Crohn's disease. A relation between TNFR1A36G and pancolitis was found in ulcerative colitis. There was no clear effect of the polymorphisms on infliximab response although, the TNFR1 minor was associated with a lower response to infliximab.
Multication Side Chain Anion Exchange Membranes (2016)

Anion exchange membrane fuel cells (AEMFCs) have been developed as promising energy conversion devices for stationary and mobile applications due to their potentially low cost. To realize high-performance AEMFCs, new polymeric membranes are needed that are highly conductive and chemically stable. Here we report a systematic study of anion exchange membranes (AEMs) with multiple cations per side chain site to demonstrate how this motif can boost both the conductivity and stability of poly(2,6-dimethyl-1,4-phenylene oxide)-based AEMs. The highest conductivity, up to 99 mS/cm at room temperature, was observed for a triple-cation side chain AEM with 5 or 6 methylene groups between cations. This conductivity was considerably higher than AEM samples based on benzyltrimethylammonium or benzyldimethylhexylammonium groups with only one cation per side chain site. In addition to high conductivity, the multication side chain AEMs showed good alkaline and dimensional stabilities. High retention of ion exchange capacity (IEC) (93% retention) and ionic conductivity (90% retention) were observed for the triple-cation side chain AEMs in degradation testing under 1 M NaOH at 80 °C for 500 h. Based on the high-performance triple-cation side chain AEM, a Pt-catalyzed fuel cell with a peak power density of 364 mW/cm2 was achieved at 60 °C under 100% related humidity.
Synthesis and Convenient Functionalization of Azide-Labeled Diacylglycerol Analogues for Modular Access to Biologically Active Lipid Probes (2008)

Cell membrane lipids have been identified as key participants in cell signaling activities. One important role is their involvement as site-specific ligands in protein-membrane binding interactions, which result in the anchoring of peripheral proteins onto cellular membranes. These events generally regulate protein function and localization and have been implicated in both normal physiological processes and those pertaining to disease state onset. Thus, it is important to elucidate the details of interactions at the molecular level, such as lipid-binding specificities and affinities, the location of receptor binding domains and multivalency in binding. For this purpose, we have designed and developed azido-tagged lipid analogues as conveniently functionalizable lipid probe scaffolds. Herein, we report the design and synthesis of the initial structure of this type, diacylglycerol analogue 2, which contains an azide tag at the sn-1 position of the lipid headgroup. Direct functionalization of this compound with a range of reporter groups has been performed to illustrate the facile access to probes of use for characterizing binding. Quantitative lipid-binding studies using protein kinase C, a known DAG-binding receptor, demonstrate that these probes are active mimetics of natural DAG. Thus, these DAG probes will serve as robust sensors for studies aimed at understanding binding interactions and as precursors for the development of analogous probes of more complex phospholipids and glycolipids.
Synthesis of amorphous films from phenylsilanes by plasma chemical vapor deposition (1988)

Abstract Phenylsilane and methylphenylsilane were decomposed by an rf (radio frequency) glow discharge to investigate the effect of aromatic substitution on the reactivity of the silanes as well as on the structures and properties of the deposited films. The spectral analyses and the optical band gaps of the films indicate that the films deposited at low rf ‐powers have polysilane‐like chains with pendant phenyl groups, and that the films deposited at high rf ‐powers are substantially silicon carbon alloys containing unsaturated carbon clusters. Although all the as‐deposited films are nearly insulators, the conductivities were improved by as such as six orders of magnitude by either a substitutional doping with diborane or a chemical doping with iodine.
Epidemiologic and Molecular Trends of “Norwalk‐like Viruses” Associated with Outbreaks of Gastroenteritis in the United States (2002)

Between July 1997 and June 2000, fecal specimens from 284 outbreaks of nonbacterial gastroenteritis were submitted to the Centers for Disease Control and Prevention for testing for "Norwalk-like viruses" (NLVs). Specimens were examined by reverse-transcription polymerase chain reaction and direct electron microscopy for the presence of NLVs. Adequate descriptive data were available from 233 of the outbreaks, and, of these, 217 (93%) were positive for NLVs. Restaurants and events with catered food were the most common settings, and contaminated food was the most common mode of transmission. Genogroup II (GII) strains were the predominant type (73%), with genogroup I strains causing 26% of all NLV-positive outbreaks. Certain GII clusters (GII/1,4,j) were more commonly associated with outbreaks in nursing home settings than with outbreaks in other settings. Strain diversity was great: one potential new sequence cluster was implicated in multiple outbreaks, and strains belonging to a tentative new genogroup were identified.
In vitro susceptibilities of Chlamydia pneumoniae (Chlamydia sp. strain TWAR) (1989)

The in vitro susceptibilities of two clinical isolates of Chlamydia pneumoniae from Brooklyn, N.Y., were determined for tetracycline, erythromycin, sulfamethoxazole, ciprofloxacin, and three new macrolides--azithromycin, clarithromycin, and roxithromycin. Clarithromycin was the most active drug tested, followed by the other macrolides, tetracycline, and ciprofloxacin.
Induced pluripotent stem cells in medicine and biology (2013)

Differentiated cells can be reprogrammed to pluripotency and other cell fates by treatment with defined factors. The discovery of induced pluripotent stem cells (iPSCs) has opened up unprecedented opportunities in the pharmaceutical industry, in the clinic and in laboratories. In particular, the medical applications of human iPSCs in disease modeling and stem cell therapy have been progressing rapidly. The ability to induce cell fate conversion is attractive not only for these applications, but also for basic research fields, such as development, cancer, epigenetics and aging.
Stable nuclear transformation of the diatom <i>Chaetoceros</i> sp. (2011)

SUMMARY A nuclear transformation system for the centric diatom Chaetoceros sp. has been established using two plasmids pTpfcp/nat and pTpNR/green fluorescent protein (GFP) that had been used for Thalassiosira pseudonana transformation. These contain the nourseothricin resistance gene ( nat ) with the fucoxanthin chlorophyll a /c binding protein ( fcp ) promoter/terminator from T. pseudonana and the enhanced green fluorescent protein gene ( egfp ), with the nitrate reductase ( NR ) promoter/terminator from T. pseudonana , respectively. Transformants were recovered in the presence of the antibiotic nourseothricin. One to four copies of both nat and egfp genes were integrated into genomic DNA of the transformants. Transformation efficiency was 1.5–6.0 transformants per 10 8 cells. This work is the first report of stable genetic transformation of Chaetoceros , which is important as not only a constituent member of marine ecosystem but also feed for aquaculture.
Nonlinear distortion correction in endoscopic video images (2000)

Modern video-based endoscopes offer physicians a wide-angle held of view for minimally-invasive procedures. Unfortunately, inherent barrel distortion prevents accurate perception of range. This makes measurement and distance judgment difficult and causes difficulties in emerging applications, such as 3D medical-image registration. Such distortion also arises in other wide field-of-view camera circumstances. This paper presents a distortion-correction technique that can automatically calculate correction parameters, without precise knowledge of horizontal and vertical-orientation. The method is applicable to any camera-distortion correction situation. Based on a least-squares estimation, our proposed algorithm considers line fits in both field-of-view directions and global consistency that gives the optimal image center and expansion coefficients. The method is insensitive to the initial orientation of the endoscope and provides more exhaustive field-of-view correction than previously proposed algorithms. The distortion-correction procedure is demonstrated for endoscopic video images of a calibration test pattern, a rubber bronchial training device, and real human circumstances. The distortion correction is also shown as a necessary component of an image-guided virtual-endoscopy system that matches endoscope images to corresponding rendered 3D CT views.
Protein localization in the human eye and genetic screen of opticin (2002)

The opticin (OPTC) gene encodes a protein that is a member of the small leucine-rich repeat protein (SLRP) family. OPTC is located on chromosome 1q31-q32 within an age-related macular degeneration (AMD) susceptibility locus. We have developed an affinity-purified N-terminal anti-opticin antibody and used it to examine opticin expression in human eye tissues. The antibody was also used for opticin protein localization in human eye sections. Immunoblots of human eye tissues detected a predominant band of approximately 62 kDa in size in iris, trabecular meshwork/ciliary body, retina, vitreous, and optic nerve. Immunohistochemical experiments revealed that opticin is specifically localized in human cornea, iris, ciliary body, vitreous, choroid and retina. Due to opticin's protein profile in the eye, we have also screened OPTC for mutations in individuals with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG) or AMD. We identified four sequence variations, all of which were observed in normal controls except for the Arg229Cys change. Three amino acid substitutions (Ile182Thr, Arg229Cys and Arg325Trp) were in residues conserved in dog, mouse, pig and human. The Arg229Cys alteration was present in a homozygous state in one individual with neovascular AMD. Examination of the other AMD afflicted family members showed that the OPTC Arg229Cys variant did not segregate with the disorder within the family. The protein localization pattern of opticin and our preliminary screen of AMD patients suggest that a larger AMD patient screen may be warranted.
Impact of New Lightwave Technologies on Terrestrial Longhaul Network Evolution (1995)

Fan and Clark discuss selection criteria for continuously upgrading network infrastructures. They recommend a technology platform based on optical amplifiers and wavelength multiplexing for upgrading existing networks, and consider the planning process and related issues.
Ultrathin carbon molecular sieve membrane for propylene/propane separation (2015)

Ultrathin (down to 300 nm), high quality carbon molecular sieve (CMS) membranes were synthesized on mesoporous γ‐alumina support by pyrolysis of defect free polymer films. The effect of membrane thickness on the micropore structure and gas transport properties of CMS membranes was studied with the feed of He/N 2 and C 3 H 6 /C 3 H 8 mixtures. Gas permeance increases with constant selectivity as the membrane thickness decreases to 520 nm. The 520‐nm CMS membrane exhibits C 3 H 6 /C 3 H 8 mixture selectivity of ∼31 and C 3 H 6 permeance of ∼1.0 × 10 −8 mol m −2 s −1 Pa −1 . Both C 3 H 8 permeance and He/N 2 selectivity increase, but the permeance of He, N 2 , and C 3 H 6 and the selectivity of C 3 H 6 /C 3 H 8 decrease with further decrease in membrane thickness from 520 to 300 nm. These results can be explained by the thickness‐dependent chain mobility of the polymer film which yields thinner final CMS membranes with reduction in pore size and possible closure of C 3 H 6 ‐accessible micropores. © 2015 American Institute of Chemical Engineers AIChE J , 62: 491–499, 2016
Joint Processing of Analog Fixed Beamforming and CSI-Based Precoding for Super High Bit Rate Massive MIMO Transmission Using Higher Frequency Bands (2015)

In order to tackle the rapidly increasing traffic, the 5th generation (5G) mobile communication system will introduce small cells using higher frequency bands with wider bandwidth to achieve super high bit rate transmission of several tens of Gbps. Massive multiple input multiple output (MIMO) beamforming (BF) is promising as one of the technologies that can compensate for larger path-loss in the higher frequency bands. Joint analog fixed BF and digital precoding have been proposed to reduce the cost of a Massive MIMO transceiver. However, the conventional scheme assumes the transmission of a few streams using well-known codebook-based precoding as the digital precoding, and both a selection method of the fixed BF weights and a digital precoder design, which are suitable for super high bit rate transmission using multiple streams, have not been studied. This paper proposes a joint fixed BF and CSI-based precoding (called FBCP) scheme for the 5G Massive MIMO systems. FBCP first selects the analog fixed BF weights based on a maximum total received power criterion, and then it calculates an eigenmode (EM) precoding matrix by exploiting CSI. This paper targets a 5G system achieving over 20Gbps in the 20GHz band as one example. Throughput performances of the Massive MIMO using the proposed FBCP are evaluated by link level simulations using adaptive modulation and coding and it is shown that the proposed FBCP with the optimum number of selected beams (baseband chains) can use higher level modulation, up to 256QAM, and higher coding rates and achieve throughputs close to 30Gbps while the cost and complexity can be reduced compared with the fully digital Massive MIMO.
The Effects of FK506 on Neurologic and Histopathologic Outcome After Transient Spinal Cord Ischemia Induced by Aortic Cross-Clamping in Rats (2001)

A single dose-injection of the immunosuppressant FK506 significantly improved neurologic outcome and attenuated spinal cord injury induced by transient thoracic aortic cross-clamping in the rat.