gebhart/patrepeval huggingface dataset:
PARÂMETROS GENÉTICOS, TENDÊNCIAS E RESPOSTA À SELEÇÃO DE CARACTERÍSTICAS PRODUTIVAS DA RAÇA NELORE NA AMAZÔNIA LEGAL (2014)

Estudos relacionados aos rebanhos de seleção situados nas novas fronteiras agrícolas do país são escassos, porém não menos importantes aos programas de melhoramento. O objetivo deste trabalho foi estimar parâmetros genéticos, efeitos não genéticos, tendência genética e resposta à seleção para características de crescimento (pesos padronizados aos 120, 210 e 450 dias) e reprodutivas (idade ao primeiro parto e perímetro escrotal aos 450 dias) de bovinos da raça Nelore criados na Amazônia Legal. O arquivo de dados consistia em 211.744 registros do PMGRN – Nelore Brasil, de animais nascidos entre 1995 e 2008 em rebanhos localizados nos Estados do AC, MA, MT, PA, RO e TO. O modelo animal considerou as cinco características simultaneamente. As herdabilidades para P120 foram: 0,24; 0,21 e 0,36 (direta, materna e total, respectivamente); para P210: 0,29; 0,16 e 0,45 e para P450, PE450 e IPP: 0,48; 0,49 e 0,22 (herdabilidades diretas). As correlações genéticas entre os pesos variaram de 0,51 a 0,78; entre os pesos e PE450 variaram de 0,26 a 0,46; entre os pesos e a IPP foram baixas e negativas, e entre PE450 e IPP foi nula. Os progressos genéticos foram superiores aos fenotípicos, com exceção da IPP. A resposta à seleção variou de 0,27 a 0,11 kg/ano; 0,49 a 0,20 kg/ano; 1,32 a 0,53 kg/ano; 0,08 a 0,03 cm/ano e 0,06 a 0,02 dias/ano para P120, P210, P450, PE450 e IPP, respectivamente. As características estudadas podem ser utilizadas como critérios de seleção.\n \n Palavras-chave: correlações, herdabilidade, tendência genética
A high-resolution active matrix using p-channel SOI TFTs (1988)

A high-quality silicon-on-insulator (SOI) layer with 3-in-diameter quartz substrate and connected silicon islands was fabricated by a radio-frequency-heated zone-melting-recrystallization method. The whole area was successfully recrystallized and 95% of the silicon layer had a
Identification of Human Papillomavirus DNA in Cervical and Vaginal Intraepithelial Neoplasia with Molecularly Cloned Virus-Specific DNA Probes (1983)

The presence of human papillomavirus (HPV) DNA was identified in the tissues of cervical and vaginal intraepithelial neoplasia by Southern blot DNA hybridization under conditions of low stringency. The specific types of HPV present in the tissues were identified by using molecularly cloned types 1 through 6 (HPV-1 through HPV-6) HPV DNA probes under high-stringency conditions. All tissues of cervical and vaginal intraepithelial neoplasia analyzed contained HPV genomes. Fifteen of 19 samples (79%) contained HPV-6 DNA, and 10 of 19 samples (53%) HPV-3 DNA. Hybridization with HPV-1, HPV-2, HPV-4, and HPV-5 DNAs was also observed in several of the samples. Four of the samples did not hybridize with any of the probes tested (HPV-1 through HPV-6); yet, all showed hybridization with an HPV-EV DNA (a type 3-related DNA) probe under low-stringency conditions, indicating the presence of HPV types other than those belonging to HPV-1 through HPV-6.
Matched expansion probe cards (1999)

Summary form only given. When testing IC's on a wafer prober a standard state of the art probe card will show a dislocation of the probe needles relative to the pad positions at elevated temperature. By separating electrical and mechanical features it is possible to have matched expansion while the actual electrical adaption of the user remains unmodified. The Matched Expansion Probe Card offers this feature for application over a range of temperatures which may be offset more than +/-200/spl deg/C from the temperature of manufacturing. The only limitations of this solution are the stability of the embedment and the liquidus temperature of the solder used. By this method the manufacturer and the maintenance group can save the need of using a hotchuck and protecting gloves. The application is field proven up to 135/spl deg/C and is actually field tested at 185/spl deg/C. Temperatures above 250/spl deg/C for electro-migration measurements have been performed in a laboratory environment.
Viscosity-Lowering Effect of Amino Acids and Salts on Highly Concentrated Solutions of Two IgG1 Monoclonal Antibodies (2015)

Monoclonal antibodies display complicated solution properties in highly concentrated (>100 mg/mL) formulations, such as high viscosity, high aggregation propensity, and low stability, among others, originating from protein-protein interactions within the colloidal protein solution. These properties severely hinder the successful development of high-concentration mAb solution for subcutaneous injection. We hereby investigated the effects of several small-molecule excipients with diverse biophysical-chemical properties on the viscosity, aggregation propensity, and stability on two model IgG1 (JM1 and JM2) mAb formulations. These excipients include nine amino acids or their salt forms (Ala, Pro, Val, Gly, Ser, HisHCl, LysHCl, ArgHCl, and NaGlu), four representative salts (NaCl, NaAc, Na2SO4, and NH4Cl), and two chaotropic reagents (urea and GdnHCl). With only salts or amino acids in their salt-forms, significant decrease in viscosity was observed for JM1 (by up to 30-40%) and JM2 (by up to 50-80%) formulations, suggesting charge-charge interaction between the mAbs dictates the high viscosity of these mAbs formulations. Most of these viscosity-lowering excipients did not induce substantial protein aggregation or changes in the secondary structure of the mAbs, as evidenced by HPLC-SEC, DSC, and FT-IR analysis, even in the absence of common protein stabilizers such as sugars and surfactants. Therefore, amino acids in their salt-forms and several common salts, such as ArgHCl, HisHCl, LysHCl, NaCl, Na2SO4, and NaAc, could potentially serve as viscosity-lowering excipients during high-concentration mAb formulation development.
A 1.1-Gb/s 4092-bit Low-Density Parity-Check Decoder (2005)

A 4092-bit low-density parity-check decoder, based on staggered decoding schedule, is implemented in a 130nm 6M CMOS technology. The rate 0.75 code is based on finite-field geometries. Serial, shift-register based architecture enables a compact decoder implementation. The chip has a 4.0mm2 core and operates at 1.1 GHz with 1.2V supply, resulting in a throughput of 1.1Gb/s per iteration.
An In Situ Study of Collagen Self-Assembly Processes (2007)

We present in situ studies on the self-assembly and dynamic evolution of collagen gels from semidilute solutions in a microfluidic device. Collagen fibrils not only reinforce the mechanical properties of bone and tissues, but they also influence cellular motility and morphology. We access the initial steps of the hierarchical self-assembly of collagen fibrils and networks by using hydrodynamic focusing to form oriented fibers. The accurate description of the conditions within the microchannel requires a numerical expression for the pH in the device as well as a modified mathematical description of the viscosity, which increases nearly 300-fold as collagen fibrils form around neutral pH. Finite element modeling profiles overlay impressively with cross-polarized microscopy images of the birefringent fibrils in the channel. Real-time X-ray microdiffraction measurements in flow indicate an enhanced supramolecular packing having a unit spacing commensurate with that of a pentameric collagen subunit. These results have significant implications for the field of biomedicine, wherein new aligned, cellularly active, and mechanically strengthened materials continue to be in demand. However, this work is also remarkable from a more fundamental, biophysical point of view because the underlying concepts may be generalized to a large pool of systems.
Tactics to Enhance the Effectiveness of Delayed Incentive Offerings in a Competitive Environment (1997)

Abstract Managers often try to gain repeat purchases by using delayed incentives such as bounce-back coupons or continuity programs that require consumers to make multiple or long-run purchases to receive the incentive's reward. Yet, given a choice, consumers presumably would rather receive their rewards sooner, than later. We used choice scenarios in a study to identify tactics that likely result in consumers' preferences for incentive offers delayed in time over competitors' offers whose rewards are realized immediately. The results suggest that offering a delayed incentive that has a higher face value than competitors' immediate incentives may result in consumers choosing the delayed reward. Additionally, framing the incentives as gains appears to be more effective at acquiring consumers' choice than framing them as reduced losses. Finally, some limited findings indicate that targeting delayed incentive programs toward consumer segments high in future time orientation may be effective at gaining choice of delayed incentive offers.
Wireless medium access control protocols (2000)

Technological advances, coupled with the flexibility and mobility of wireless systems, are the driving force behind the Anyone, Anywhere, Anytime paradigm of networking. At the same time, we see a convergence of the telephone, cable and data networks into a unified network that supports multimedia and real-time applications like voice and video in addition to data. Medium access control protocols define rules for orderly access to the shared medium and play a crucial role in the efficient and fair sharing of scarce wireless bandwidth. The nature of the wireless channel brings new issues like location-dependent carrier sensing, time varying channel and burst errors. Low power requirements and half duplex operation of the wireless systems add to the challenge. Wireless MAC protocols have been heavily researched and a plethora of protocols have been proposed. Protocols have been devised for different types of architectures, different applications and different media. This survey discusses the challenges in the design of wireless MAC protocols, classifies them based on architecture and mode of operation, and describes their relative performance and application domains in which they are best deployed.
Epidemiologic, Clinical, and Laboratory Findings of Human Ehrlichiosis in the United States, 1988 (1990)

In 1988, the Centers for Disease Control and the Oklahoma State Department of Health identified 40 patients who had a fourfold or greater change in antibody titer in response to Ehrlichia canis. The median age of these patients was 42 years, 83% were male, 76% became ill between May and July, and 92% reported recent exposures to ticks. Patients resided in or were exposed to ticks in 14 states, including five where ehrlichiosis had not been reported before 1988. Thirty-four patients (85%) were hospitalized, and many had serious complications, including acute respiratory failure (seven patients), encephalopathy (six patients), and acute renal failure (four patients). Pulmonary infiltrates were demonstrated in 14 patients, cerebrospinal fluid pleocytosis was seen in 10 patients, and elevated levels of serum creatinine were demonstrated in eight patients. Two patients, both of whom had preexisting medical problems, died. Nonhospitalized patients received tetracycline therapy earlier in the course of their illness than hospitalized patients. There was no significant difference in the interval from initiation of antibiotic therapy to the first day of defervescence between patients treated with tetracyclines and those treated with chloramphenicol.
Unintended Thermal Injuries from Radiofrequency Ablation: Organ Protection with an Angioplasty Balloon Catheter in an Animal Model (2014)

Using balloon interposition as a protective device has advantages over previous saline infusion or CO2 insufflation, providing a safe way to expand percutaneous RFA of liver tumors located on the undersurface of the diaphragm. In addition, this method may be used in protection of other organs adjacent to areas being ablated.
2-GHz frequency-domain fluorometer (1986)

We developed a frequency-domain fluorometer which operates from 4 to 2000 MHz. The modulated excitation is provided by the harmonic content of a laser pulse train (3.76 MHz, 5 ps) from a synchronously pumped and cavity dumped dye laser. The phase angle and modulation of the emission are measured with a microchannel-plate photomultiplier (PMT). Cross-correlation detection is performed outside the PMT. The high-frequency signals for cross correlation were obtained by multiplication of the output from a 500-MHz frequency synthesizer. The performance was verified in several ways, including measurement of known time delays and examination of standard fluorophores. The detector displayed no detectable color effect, with the 300–600-nm difference being less than 5 ps. The precision of the measurements is adequate to detect differences of 20 ps for decay times of 500 ps. A correlation time of 53 ps was found for indole in water at 20 °C. The shortest correlation time we measured was 15 ps for indole in methanol/water (75/25) at 40 °C. Also, the 2-GHz data reveal the time-dependent ((t)1/2) terms found in the presence of collisional quenching. The degree of random error is about 0.3° of phase and 0.005 in modulation throughout the frequency range.
fMPE-MAP: improved discriminative adaptation for modeling new domains (2007)

Maximum a posteriori (MAP) adaptation and its discriminative variants, such as MMI-MAP (maximum mutual information MAP) and MPE-MAP (minimum phone error MAP), have been widely applied to acoustic model adaptation. This paper introduces a new adaptation approach, fMPE-MAP, which is an extension to the original fMPE (feature minimum phone error) algorithm, with the enhanced ability in porting Gaussian models and fMPE transforms to a new domain. We applied this approach to the SRI-ICSI 2007 NIST meeting recognition system, for which we ported our conversational telephone speech (CTS) and broadcast news (BN) models to the meeting domain. Experiments showed that the proposed fMPE-MAP approach has comparable or better performance than simply training the fMPE transform on combined data, in addition to the obvious speed advantage. In combination with MPE-MAP, we obtained about 20% relative word error rate reduction on a lecture meeting evaluation test set, over the models trained with the standard MAP approach.
An Artificial Esophagus Constructed of Cultured Human Esophageal Epithelial Cells, Fibroblasts, Polyglycolic Acid Mesh, and Collagen (1999)

We have been developing an artificial esophagus constructed of autologous esophageal component cells by cell culture. Because human esophageal epithelial cells are stratified in 20 layers, we attempted to construct an artificial esophageal epithelium 20 twenty layers thick. In in vitro experiments, we investigated how keratinocyte growth factor produced by fibroblasts accelerates the proliferation and differentiation of epithelial cells. Esophageal epithelial cells were cultured on collagen sheets in which dermal fibroblasts (0, 1, 4, 8 x 10(5) cells/ml of collagen) were embedded. In cultured epithelial cells on collagen gels without fibroblasts, 2.1 layer stratification was observed on the 21st day. With 1 x 10(5) fibroblasts/ml of collagen, 3.0 layer stratification was observed, 5.0 layers with 4 x 10(5) fibroblasts, and 18.1 layers with 8 x 10(5) fibroblasts. The degree of epithelial cell stratification was thus correlated with the number of embedded fibroblasts. Tubes constructed of a polyglycolic acid mesh frame, a collagen layer with esophageal fibroblasts, and an inner layer of esophageal epithelial cells were transplanted into muscle flaps of athymic rats. The luminal structures were observed to be patent without stenosis for 14 days. Histology of the epithelium revealed 20 layers of stratification. We thus succeeded in constructing epithelium similar to human esophageal epithelium. In the future we will attempt to use the tubular structures as a substitute for the esophagus after esophagectomy.
Identification of five novel mutations in the porphobilinogen deaminase gene (1994)

We have studied the porphobilinogen deaminase gene transcripts from seven unrelated patients from the West of Scotland, all suffering from acute intermittent porphyria. This was achieved by reverse transcription and PCR amplification of mRNA followed by asymmetric amplification and direct sequencing. Five novel and two previously described mutations were identified and found to be single base substitutions. Of the five novel mutations, three were missense (R116Q, T2691, G274R) and two were nonsense (Q204 Stop, W283 Stop). Using Escherichia coli PBGD as a model, it is possible to predict and explain the deleterious effects that these mutations might have on the function and structure of the enzyme.
Smartphone quantifies Salmonella from paper microfluidics (2013)

Smartphone-based optical detection is a potentially easy-to-use, handheld, true point-of-care diagnostic tool for the early and rapid detection of pathogens. Paper microfluidics is a low-cost, field-deployable, and easy-to-use alternative to conventional microfluidic devices. Most paper-based microfluidic assays typically utilize dyes or enzyme-substrate binding, while bacterial detection on paper microfluidics is rare. We demonstrate a novel application of smartphone-based detection of Salmonella on paper microfluidics. Each paper microfluidic channel was pre-loaded with anti-Salmonella Typhimurium and anti-Escherichia coli conjugated submicroparticles. Dipping the paper microfluidic device into the Salmonella solutions led to the antibody-conjugated particles that were still confined within the paper fibers to immunoagglutinate. The extent of immunoagglutination was quantified by evaluating Mie scattering from the digital images taken at an optimized angle and distance with a smartphone. A smartphone application was designed and programmed to allow the user to position the smartphone at an optimized angle and distance from the paper microfluidic device, and a simple image processing algorithm was implemented to calculate and display the bacterial concentration on the smartphone. The detection limit was single-cell-level and the total assay time was less than one minute.
End-to-end integration of a Convolutional Network, Deformable Parts Model and non-maximum suppression (2015)

Deformable Parts Models and Convolutional Networks each have achieved notable performance in object detection. Yet these two approaches find their strengths in complementary areas: DPMs are well-versed in object composition, modeling fine-grained spatial relationships between parts; likewise, ConvNets are adept at producing powerful image features, having been discriminatively trained directly on the pixels. In this paper, we propose a new model that combines these two approaches, obtaining the advantages of each. We train this model using a new structured loss function that considers all bounding boxes within an image, rather than isolated object instances. This enables the non-maximal suppression (NMS) operation, previously treated as a separate post-processing stage, to be integrated into the model. This allows for discriminative training of our combined Convnet + DPM + NMS model in end-to-end fashion. We evaluate our system on PASCAL VOC 2007 and 2011 datasets, achieving competitive results on both benchmarks.
Role of complement in neutralization of respiratory syncytial virus (2004)

Serum neutralizing antibody titers to respiratory syncytial virus (RSV) are higher when assayed with guinea pig complement. A number of different mechanisms have been suggested for enhancement of neutralization by complement. The most straightforward is that complement-antibody complexes present a greater steric hindrance to viral entry than with antibody alone. To define the implications of measuring serum neutralizing antibody with and without complement, sera from adults, young children, infants, and cord bloods were run in plaque neutralization assays with representative viruses of the RSV A and B subgroups. Although titers of neutralizing antibody were higher in the presence of complement, the addition of complement did not increase the ability to detect antibody rises after natural infection. Some of the complement effect may be attributable to an inhibition of RSV replication by complement alone. While these observations do not address the role for complement in the pathogenesis of RSV infection, they suggest that neutralization assays performed without complement may be most reflective of physiologic conditions in the respiratory tract.
Interactive implicit modeling with hierarchical spatial caching (2006)

Complex implicit CSG models can be represented hierarchically as a tree of nodes (the BlobTree) . However, current methods cannot be used to visualize changes made to these models at interactive rates due to the large number of potential field evaluations required. A hierarchical spatial caching technique is presented which accelerates evaluations of the potential function. This method introduces the concept of a caching node inserted into the implicit model tree. Caching nodes store exact potential field values at the vertices of a voxel grid and rely on tri-linear and tri-quadratic reconstruction filters to locally approximate the potential field of a sub-tree. A lazy evaluation scheme is used to avoid expensive pre-computation. Polygonization timings with and without caching are compared for a complex model undergoing manipulation in an interactive modeling tool. An order-of-magnitude improvement in visualization time is achieved for complex implicit models containing thousands of primitives.
The Design, Synthesis, and Evaluation of Organ-Specific Iron Chelators (2006)

A series of iron chelators, three (S)-4,5-dihydro-2-(2-hydroxyphenyl)-4-methyl-4-thiazolecarboxylic acid (DADFT) and three (S)-4,5-dihydro-2-(2-hydroxyphenyl)-4-thiazolecarboxylic acid (DADMDFT) analogues are synthesized and assessed for their lipophilicity (log Papp), iron-clearing efficiency (ICE) in rodents and iron-loaded primates (Cebus apella), toxicity in rodents, and organ distribution in rodents. The results lead to a number of generalizations useful in chelator design strategies. In rodents, while log Papp is a good predictor of a chelator's ICE, chelator liver concentration is a better tool. In primates, log Papp is a good predictor of ICE, but only when comparing structurally very similar chelators. There is a profound difference in toxicity between the DADMDFT and DADFT series: DADMDFTs are less toxic. Within the DADFT family of ligands, the more lipophilic ligands are generally more toxic. Lipophilicity can have a profound effect on ligand organ distribution, and ligands can thus be targeted to organs compromised in iron overload disease, for example, the heart.
Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma (1994)

These data show that global DNA hypomethylation is a significant epigenetic event in cervical carcinogenesis and that the degree of DNA hypomethylation increases with the grade of cervical neoplasia. These data suggest that global DNA methylation may serve as a biochemical marker of cervical neoplasia.
Myocardial protection by calcium antagonists (1994)

Fundamental Properties of Calcium Antagonists Including Classification and Molecular Action (L. Opie). Intracellular Calcium Overload--A Cytosolic Principle: Cellular Protection by Calcium Antagonists (G. Fleckenstein--Grun). The Ischemic Myocardium and Calcium Antagonists (W. Nayler). Angina Pectoris and Calcium Antagonists (L. Opie). Myocardial Infarction Sudden Cardiac Death Reperfusion and Stunning (L. Opie). Postinfarct Prophylaxis by Calcium Antagonists (J. Hansen). Left Ventricular Hypertrophy and Calcium Antagonists (F. Messerli & F. Soria). Calcium Antagonism and Left Ventricular Dysfunction (L. Opie). Myocardial Protection by Calcium Channel Antagonists in Clinical Practice (R. Ferrari & O. Visioli). Outlook for the Future Can End--Stage Heart Disease Be Prevented? (L. Opie). Epilogue (L. Opie). Index.