fschieber/wit-captions huggingface dataset:
n Natürl. Grösse. Acrocephalus streperus (Vieill.) Teich roh rsänger. i Männchen. Acrocephalus streperus horticolus (Naum.) Garten roh rsänger. 3 Männchen. Acrocephalus palustris (Bechst.) Sumpf roh rsänger. 2 Männchen. Acrocephalus palustris fruticolus (Naum.) Buschrohrsänger. 4 Männchen.
English: See Image:Hällungen-näckrosor.JPG. This image shows the cliffs near the beach of Bastevik
Français : Canourgues - Église Saint-Martin - Vestiges de peintures murales et d'une litre funéraire dans le chœur
English: Astronaut Robert L. Satcher Jr., STS-129 mission specialist, participates in the mission's first session of extravehicular activity (EVA) as construction and maintenance continue on the International Space Station. During the six-hour, 37-minute spacewalk, Satcher and astronaut Mike Foreman (out of frame), mission specialist, installed a spare S-band antenna structural assembly to the Z1 segment of the station's truss, or backbone. Foreman and Satcher also installed a set of cables for a future space-to-ground antenna on the Destiny laboratory and replaced a handrail on the Unity node with a new bracket used to route an ammonia cable that will be needed for the Tranquility node when it is delivered next year. The two spacewalkers also repositioned a cable connector on Unity, checked S0 truss cable connections, and lubricated latching snares on the Kibo robotic arm and the station's mobile base system.
西海市西彼町 20150920
English: PEARL HARBOR (Jan. 12, 2010) Secretary of State Hillary Rodham Clinton views the names of U.S. Sailors killed in the December 7, 1941 Japanese attack on Pearl Harbor during her visit to the USS Arizona Memorial in Pearl Harbor, Hawaii. Clinton is on a trip through the Pacific region to strengthen ties with partner nations and will stop in Australia, New Zealand, and Papua New Guinea. (U.S. Air Force photo by Tech. Sgt. Cohen A. Young/Released)
Français : Flabellina pedata (Montagu, 1815), Peyssonnelia squamaria (S. G. Gmelin) Decaisne, 1839 - Banyuls-sur-Mer : 08/84
English: Bourbon County Confederate Monument in Paris, Kentucky. Template:DYKfile
English: Whewellite Locality: Burgk, Dresden, Saxony, Germany (Locality at mindat.org) Size: thumbnail, 1.2 x 1 x .2 cm Whewellite This a very gemmy and rare example of the species: clear, very good luster, and excellent form. Truly oustanding old specimen! Complete all around save the bottom edge as shown. 1.2 x 1 x .2 cm Deutsch: Whewellit Fundort: Burgk, Dresden, Sachsen, Deutschland (Fundort bei mindat.org) Größe: 1.2 x 1 x .2 cm
Deutsch: Wohnhaus, zweigeschossiger und giebelständiger, verschalter Blockbau mit vorschießendem Flachsatteldach, 1. Drittel 19. Jahrhundert
English: The former Rose and Crown, Halifax Road, Todmorden A mid-18C building according to the English Heritage listing details. It became Big D's Bikercafé Bar. Now I suspect it might be a restaurant or guest house - I didn't go up to the door to read the small notices. The Rose and Crown is still mentioned in numerous websites. Perhaps it is to become a restaurant using the old name. To the right there is a truncated mill chimney with a tree growing from it.
Youzhny WM16 (13)
Deutsch: Gebäude mit Obergeschoss im Zentrum von Elisabethszell; Zum Teil mit verputztem Blockbau aus dem 18./19. Jhd. Liste der Baudenkmäler in Haibach.
English: Manokin Presbyterian Church of Princess Anne, Maryland, built in 1765, is one of the earliest Presbyterian congregations founded in the United States.
English: Naval bunker in Karaburun
Nederlands: Onroerend erfgoed in Aalter: voormalige herberg De Tramstatie (Heirstraat nr. 25)
Unidentified blind snake (infraorder Scolecophidia).
Soldiers Memorial Statue in Bedourie
English: Oulu seen from the Joutsensilta bridge. Suomi: Oulun Joutsensillalta nähtynä.
Español: María Gabriela Chávez
Colibri 1908
Català: Imatge corporativa del festival.
English: protected building in tjøme
English: Author Ian Stuart Black
Nederlands: Detail van Capucijnenstraat 57, een 18e-eeuws huis in régencestijl, in het Statenkwartier in het centrum van Maastricht.
English: Ofer Hadad עברית: עופר חדד
This is a photo of onroerend erfgoed number 52442
Deutsch: Bildungssäule
English: Angophora robur growing near Kremnos, New South Wales
English: Saint Eldrado chapel, Novalesa Abbey, Turin, Italy Italiano: Cappella di Sant'Eldrado, Abbazia di Novalesa, Torino, Italia
Deutsch: Haus des Wasserbehälters auf der Flur "Im Spies" südöstlich von Framersheim, Gemeinde Alzey-Land, Landkreis Alzey-Worms, Rheinland-Pfalz, Deutschland. Kulturdenkmal gemäß Denkmalliste des Landes Rheinland-Pfalz (Stand: 31. Juli 2018). Bossenquader-Typenbau mit Vorhalle, bezeichnet 1907, Inschrift: "Wasserbehälter Framersheim".
中文: 芜湖圣母院旧址，原修道院，南侧中部。
Français : panneau de sentier à Bellechambre
One of my archieves. I'm away from my friends as I'm in KSA, and I have nothing to do !! So, I played with those programs just for fun. But I found this one maybe u like it :) .I wish this could express the future :). I was trying to know what my photo's would appear by Artie's way :)) Location: Bibliotheca Alexandria, Alexandria, Egypt Photomatix: Mixing 4 Copies of different exposure (+4..2..-2..-4) Photoshop: Playing with layers but I forgot what I made :)). Lightroom: Clarity to confirm the edges + Midpoint
中文: 泉州公交201路，闽CYA482
English: Kawaii Kon 2015 crowd for opening ceremony.
English: English billiards and snooker player Willie Smith
Nederlands: Linker pand van rijtje van vier. Voorgevel bevat elementen uit de neorenaissance (de speklagen) en de jugendstil (bekroning dakkapel voorzijde). In de dakkapel een dubbele deur, het zijn niet de originele deuren, maar het is wel de originele indeling. De achtergevel is sterk gewijzigd, de gevel is doorgetrokken naar de eerste verdieping. Het interieur is eveneens niet meer oorspronkelijk.
Slovenčina: Loď s turistami a ostrov s majákom, Chorvátsko.English: Boat with tourists and island with a lighthouse, Croatia.Čeština: Loď s turisty a ostrov s majákem, Chorvatsko.Hrvatski: Brodica s turistima i otok sa svjetionikom, Hrvatska.Русский: Лодка с туристами и остров с маяком, Хорватия.Slovenščina: Čoln s turisti in otok s svetilnikom, Hrvaška.
Porto antico di Genova Terminal traghetti e Matitone
Grange Road railway station
Arrondissement_de_Douai
Čeština: Bývalý kaolinový důl u obce Nevřeň (okres Plzeň-sever), zpřístupněný veřejnosti v roce 2019. Propadliny nad dolem English: China-clay mine in Nevřeň, Plzeň-North District, Czech Republic
English: Chaidir Anwar Sani as Indonesia Ambassador to Belgium
Nederlands: Overzicht over Brug 305, Karl Popperbrug
Kholmsk, Sakhalin Oblast, Russia, 694620
Русский: Щит рассечен. В правой золотой части, червленая крепостная башня. В левой лазуревой части, золотой сноп пшеницы. Щит увенчан Дворянским коронованным шлемом. Нашлемник: выходящий казак Малороссийского казачьего войска. Намет: справа - червленый с золотом, слева - лазуревый с золотом.
Berlin-Biesdorf, Püttlinger Str.
English: 1025 Park Avenue in Manhattan, a New York City Designated Landmark
Français : Villeneuve-sur-Lot - Église Sainte-Catherine - Vitrail ancien (baie n° 24) : Comment notre Seigneur à la fin du monde viendra juger les vivants et les morts
Polski: Stacja kolejowa
Biblioteca Central USAC
中文: 1964-03 1964年 广西西津水电站
English: Institute of Directors Logo
Русский: Фотография Бориса Моисеевича Берлина (1906-1995)
English: Italy, Lombardy, province of Varese, Leggiuno (on Lake Maggiore), Santa Caterina del Sasso monastery, couvent Italiano: Italia, Lombardia, provincia di Varese, Leggiuno (sul lago Maggiore), eremo di Santa Caterina del Sasso, convento
Русский: Игорь Борисович Дивинский (род.1957) — российский государственный и политический деятель
Deutsch: Evangelisches Gemeindebüro/Pfarramt Oberhörlen, Pfarrweg 1
English: kelton headshot tiff
Information: Leipziger Herbstmesse: Universalnarkoseeinheit Medimorph Ausgabepreis: 10 Pfennig First Day of Issue / Erstausgabetag: 28. August 1975 Auflage: 7.000.000 Entwurf: Jochen Bertholdt Druckverfahren: Rastertiefdruck Michel-Katalog-Nr: Ländercode-MiNr: 2076
Українська: Іконостас з с.Скварява Нова Львівської обл. (т.зв. Жовківський іконостас): Преображення Господнє. Художник Іван Руткович. Дошка липова, левкас, темпера, олія, гравіювання, золочення. Зберігається у Львівському Національному музеї. English: Iconostasis from the village Skvariava Nova, Lviv Oblast. Originally painted for the Church of Christ's Nativity in Zhovkva: Transfiguration, painted by Ivan Rutkovych. Tempera, oil on gesso-grounded lime panel, engraving, gilding. Now in Lviv National Museum.
English: Amelanchier sanguinea (Pursh) DC. - roundleaf serviceberry
Italiano: Facciata della chiesa di San Gregorio Papa al Capo
English: Carex virescens Muhl. ex Willd. - ribbed sedge
Nederlands: De Blindeweg in Montfoort.
English: Dublin postal district street sign of Hendrick Lane, Dublin in 2019
Deutsch: Sägewerk Metzner in Meran   This media shows the cultural heritage monument with the number 50393 in South Tyrol.
English: Puʻupehe Islet (also known as Sweetheart Rock) interpretive sign at Kapihaʻā village site, Lānaʻi, Hawaiʻi, on National Register of Historic Places
English: The sign for the historic Congregational Church of Patchogue on East Main Street in Patchogue, New York. I wanted to capture an image of both the sign and the clock tower, but my cheap disposable camera wouldn't allow me to do that.
Deutsch: 17.06.2017 09623 Rechenberg (Rechenberg-Bienenmühle) An der Schanze 1 (GMP: 50.736078,13.556243): Die Burg wurde erstmals 1270 urkundlich mit Apitz de Rechenberg erwähnt. 1586 vernichtete ein Feuer die Oberburg. Unter Heinrich von Schönberg entstand das 1605 vollendete Herrenhaus (GMP: 50.736335,13.555915) zu Füßen des Burgberges. Seit 1877 im Besitz der Gemeinde Rechenberg und als Schulhaus genutzt. Ab 1993 Sitz der Gemeindeverwaltung (Rathaus). [SAM0421.JPG]20170717200DR.JPG(c)Blobelt
IMG_3524.JPG
Français : Romainmôtiers
English: A fountain outside the Luther Store in Swansea, Massachusetts. This is an image of a place or building that is listed on the National Register of Historic Places in the United States of America. Its reference number is 78000438
COLLEVILLE-SUR-MER, France – President Barack Obama speaks to an audience of more than 14,000 during a ceremony to honor World War II veterans as part of the 70th Anniversary of D-Day at the American Cemetery here, June 6, 2014. The event was one of several commemorations of the 70th Anniversary of D-Day operations conducted by Allied forces during World War II June 5-6, 1944. Over 650 U.S. military personnel have joined troops from several NATO nations to participate in ceremonies to honor the events at the invitation of the French government. <a href="http://www.eucom.mil/key-activities/featured-events/d-day-june-6-1944" rel="nofollow">www.eucom.mil/key-activities/featured-events/d-day-june-6...</a> (U.S. Air Force photo/Staff Sgt. Sara Keller)
Українська: Циганський табір (с.Дубове)
danba
English: Simeria train station.Română: Gara Simeria. This is a photo of a historic monument in județul Hunedoara, classified with number HD-II-m-B-03449
English: Tat Aluf (Brig. Gen.) Yaniv Asor, Head of operations brigade. עברית: תת אלוף יניב עשור בטקס מינויו למפקד חטיבת המבצעים באמ"ץ.
English: Logo of the doom metal band Uncle Acid & the deadbeats Italiano: Logo del gruppo musicale doom metal Uncle Acid & the deadbeats
This is an image of rijksmonument number 515135
Español: Villa Real train station, used as a parking lot. Español: Modificación realizada por la Compañía de Transportes de la Ciudad de Buenos Aires
Polski: Bogdan Oleszek, gdański działacz związkowy i samorządowy.
Nederlands: Maria van Bourgondiëlaan in Hagenkamp, Eindhoven-Gestel
English: 22209 Mumbai New Delhi Duronto Express - Pantry Car coach
日本語: JR東北本線（宇都宮線）・栗橋駅のホーム English: Platform of JR Tohoku-Main-Line (Utsunomiya-Line) Kurihashi Station Sony NEX-3
English: Detail of the window dedicated to Captain William John Nutman, AM at the Church of St Sabinus in Woolacombe in Devon showing SS Aidar
Deutsch: Haus Friedrichstraße 33 in der Dresdner Friedrichstadt
Notera Av dokumentationsskäl har originalbeskrivningen från Riksantikvarieämbetet behållits. Tillrättalägganden och alternativa beskrivningar bör införas separat från nedanstående information. Felaktigheter kan även anmälas till denna sida. Motiv: Gärde Nyckelord: Flygbilder, Riksintressen Kategori: JordbruksbyGärde
Português: Prefeito de Campo Maior (Piauí) Paulo Cesar Martins e a vice Silvia do Caú em cerimôiade lançamento do selo postal Cemitérios Brasileiros no Palácio do Jenipapo em 17/08/2013.
English: Surroundings of Kaloxilos Naxos Cyclades Greece
Deutsch: Villacher Kirchtag 2017 mit Musik und Tanz vor der Stadtpfarrkirche English: Folklore Festival 2017 in Villach, Carinthia, Austria, EU in traditional clothing
Deutsch: Plauen, denkmalgeschütztes Haus in der Marktstraße (Marktstraße 15).
English: Sergeant at arms of the US
Español: El Brigadier Mayor Jorge Horacio Landaburu.
"L'homme du jour : M. Langlois".
Wambrook: Wambrook Methodist Chapel
Nederlands: Het park bij huis Singraven te Denekamp. This is an image of rijksmonument number 519488
Español: Vista panorámica del tablero metálico en construcción del Enlace del Río San Pedro
Español: Células caliciformes productoras del moco en el íleon de ratón.
Wikivoyage-style map of the Scottish Borders region showing the major cities.
Plemyria rubiginata, to MV light, Hellerup, Denmark, 17 July 2003
Română: Brașov pe înserat, vedere de pe Tâmpa. Cartierul Șcheii Brașovului in prim plan.
Français : Mur intérieur du logis du château de Pouancé
中文: 20190801中央公园站工地
Jacob und Rahel, nach einer Vorlage von Schnorr von Carolsfeld
English: A fruit seller by a canal oil on canvas 39.3 x 33 cm signed c.l.: M. Naiveu fet/1687
Deutsch: Die Burg liegt im Osten von Betuwe in der Mitte von Geldernland in den Niederlanden.
English: People watching the monument "Door of no Return" in Ouidah Benin Jan 2018
Deutsch: Gottlieb "Samiel" Wagner (1794-1878), Weinbergarbeiter und Gastwirt auf der Rudelsburg, Darstellung von 1877, Rechte abgelaufen, Public Domain
Das romanische Eingangsportal es Turms
English: Structure of LY-215,840
Українська: Ботанічний сад на березі річки Сапалаївки This is a photo of a natural heritage site in Ukraine, id: 07-101-5007
Nederlands: Diest Leuvensestraat 81 This is a photo of onroerend erfgoed number 212760
English: East approaches to highway and railroad bridges across the Columbia River reservoir at Kettle Falls.
English: Cattle brand of Abtsdorf/Apoş/Szászapátfalva Deutsch: Viehbrandzeichen von Abtsdorf Română: Danga pentru vitele din Apoş Magyar: Szászapátfalva szarvasmarha márka
English: Pologons in Noachis quadrangle, as seen by HiRISE under HiWish program Boxes surround individual polygons.
English: Chiesa di San Francesco d'Assisi (città di San Cataldo, provincia Caltanissetta)(2).jpg
Nederlands: Haarlemmerdijk 40 Amsterdam
English: HENRY MORGENTHAU VISITING TO ISRAEL. IN PHOTO, PRES. CHAIM WEIZMAN (R) MEETING U.S. SECY. OF FINANCE HENRY MORGENTHAU IN REHOVOT.
English: The reverse of the Indian Head cent from 1860 to 1909. This particular coin was minted in 1909 at the Philadelphia mint (no mint mark) and is graded MS65RD (red) by the Numismatic Guaranty Corporation (NGC). It is housed in a plastic NGC EdgeView holder (one can see the minimally viewable white prongs holding the edge of the coin). The reverse design was similar for 1859 cents, but featured a laurel wreath (instead of the oak wreath seen here), and did not include the shield.
Español: Jueves 22 de febrero de 2018. El Rector de la Universidad Nacional Autónoma de México Enrique Graue, acompañado de la secretaria de Cultura del Gobierno Federal, María Cristina García Cepeda; del gobernador del estado de Campeche, Alejandro Cárdenas Moreno y del secretario de Cultura de la CDMX, Eduardo Vázquez Martín, inauguró la 39 Feria Internacional del Libro del Palacio de Minería. Además de los antes mencionados, acudieron Carlos Agustín Escalante Sandoval, director de la Facultad de Ingeniería de la UNAM; Jaime Valls Esponda, secretario general ejecutivo ANUIES; Gerardo Montero Pérez, rector de la Universidad de Campeche; Carlos Anaya Rosique, director de la CANIEM y Fernando Macotela Vargas director de la FIL de Minería. Fotografía: Milton Martínez / Secretaría de Cultura CDMX.
Français : Vic-le-Comte - Maison rue du Palais
English: The Alamo in San Antonio,Texas
Français : Façade de la chapelle Saint-André (ruines), à Estoublon
English: Photograph of houses in Firth House Lane, Rastrick, Calderdale, West Yorkshire, England
One man and his horse
Slovenčina: Opevnenie kostola This media shows the protected monument with the number 601-2/2 (other) in the Slovak Republic.
Deutsch: Rom.-kath. Pfarrkirche St. Stefan (Finkenstein), das alte Friedhofskreuz in der äußeren Vorhalle   This media shows the protected monument with the number 67948 in Austria. (Commons, de, Wikidata)
English: St John the Baptist's parish church, Manchester Road, Baxenden, Lancashire, seen from the east
Svenska: Silos vid Västra Hamnbassängen, Malmö
English: Moscow, 7 October 2015. Angolan Minister of Telecommunications and Information Technologies during a working meeting with Russian Minister of Telecom and Mass Communications Nikolay Nikiforov. Русский: Москва, 7 октября 2015. Министр телекоммуникаций и информационных технологий Республики Ангола Жозе Карвалью да Роша во время рабочей встречи с министром связи и массовых коммуникаций Российской Федерации Николаем Никифоровым.
English: Camporsevoli, Village in the territory of Cetona, Monte Cetona, Province of Siena, Tuscany, Italy
English: Naning Metro Line 3 - Xiaojicun Station's Column.
Ausgabepreis: 20 Pfennig First Day of Issue / Erstausgabetag: 16. Mai 1972 Auflage: 13.000.000 Entwurf: Gottschall Druckverfahren: Rastertiefdruck Michel-Katalog-Nr: Ländercode-MiNr: 1755 Licensing This file is most likely NOT in the public domain. It has been marked for review, and will be deleted in due course if the review does not find it to be in the public domain.This file was previously considered to be in the public domain as a German stamp; it is possible that it is in the public domain for other reasons, in which case a new rationale will be applied as part of the review process. See below for the previous rationale. Previous public domain rationale, no longer applicable This stamp is in the public domain in Germany because it was released by the postal administration of the German Democratic Republic or the Soviet occupation zone (Deutschen Post der DDR) whose legal successor is the Federal Republic of Germany. Thus it is an official work according to German copyright law (§ 5 Abs. 1 UrhG). Boarisch | Deutsch | English | suomi | македонски | Türkçe | +/−
English: Axion-horse 日本語: アクシオン
Français : L'écluse à double bassin de Rybinsk, Russie. (Vue Sud/Sud-Est vers la Volga)
Deutsch: Lage des Kantons Perpignan-4
Українська: Вхід до парку відпочинку
Français : Logo concours gamay
Čeština: Zámek ve Veselí nad Moravou
Deutsch: Only known photograph of the famous Charter Oak of Connecticut before it fell in a storm 1856. The file record of the Connecticut Historical Society lists one "Edwin P. Kellogg" as the photographer; however, in most available sources it is attributed to Nelson Augustus Moore (1824-1902).
Barbara Rylska
Deutsch: Feuchtgebiet in der Nähe der Rastneralm, bei Rodeneck, Südtirol
Русский: Дом серии Щ-5416
Nota que menciona los deportes practicados por el RC Recreativo de Huelva en 1889
English: Grande Ronde River Bridge This is an image of a place or building that is listed on the National Register of Historic Places in the United States of America. Its reference number is 95000262
Polski: Herb KS Pomorzanin Toruń
English: Euclides Miragaia profile. He was a Brazilian student and martyr of the Constitutionalist Revolution of 1932.
Español: Banca pintada por Macarena Matte en avenida Isidora Goyenechea, Las Condes
Русский: Воронежская область. Новоусманский район. Деревья в мае в д.Битюг
Marienstraße 39, Wuppertal
Français : Parochiekerk Sint-Jozef This is a photo of onroerend erfgoed number 12837 This photo was uploaded with Wiki Loves Monuments mobile 1.2.1 (Android).
Deutsch: Blick von Norden auf das Stauwehr Horkheim am südlichen Ende des dortigen Neckar-Altarms
English: Site plan of the Château de Chanteloup
Čeština: Kulturní památka dům Komenského čp. 1 v Jihlavě, okr. Jihlava. English: Cultural monument house Komenského 1 in Jihlava, Jihlava District.
English: Eldership, Daugėdai, Rietavas Municipality, Lithuania Русский: Староство, д. Даугедай, Ретавское самоуправление, Литва
日本語: 8月9日、横浜文化体育館大会でデビュー
Русский: Профессор В.Н. Виноградов
Српски (ћирилица)‎: Фотографија ентеријера Позајмног одељења Библиотеке „Вук Караџић“ у Пријепољу
Русский: Тюльпан свит гармони.
Poljanski Lug - Ulaz
English: Dubuis House. The two original rooms in this house were erected 1847 by Father Claude M. Dubuis, from Lyons, France, aided by Father Chazelle (who soon died of typhus). Father Dubuis, the first priest in Castro's colony, was captured twice by Comanches in 1847, but escaped unharmed. He later was Bishop of Texas. This house replaced a picket hut. It was first example of French-Alsatian architecture in Castroville. Recorded Texas Historic Landmark, 1966. Incise in base: Restored 1965 by Mr. & Mrs. G.G. Gillette. #1291
English: Seal of the California Courts of Appeal
English: Shoulder board of Senior Soldier of Ukrainian Armed Forces Українська: Погон старшого солдата Збройних сил України Русский: Погон старшего солдата Вооруженных Сил Украины
Čeština: Bílá Hora (Plzeň) - památný strom - dub u Boleveckého rybníka
Français : Grébault-Mesnil, Onicourt, Somme, Fr, chapelle
Deutsch: Villa Ringstraße 25 in Neunkirchen (Saar)
Osterode am Harz, Aegidienstraße 22
English: The single Fairey F.2 built pictured at Harlington in 1917.
ANCIENT AMVRAKIA
Français : "M. Fernand Xau, directeur du Journal".
Français : Lausanne - Sparta Prague 75 : Jan Piskáček
English: K.u.k. Infanterieregiment Nr. 53
Português: Cataratas do Iguaçu 中文（繁體）‎: 巴西伊瓜蘇瀑布
Einbeck, Tiedexer Straße 5
Français : Embarquement des troupes a Prahia Grande : pour l'expédition contre Monte-Video [Iconográfico] Imprenta Paris [França] : Firmin Didot Frères, 1839.
Deutsch: Sohlgleite der Leine zwischen Bovenden und Nörten-Hardenberg
(a) SCF contains three core subunits—the RING protein Rbx1, the cullin Cul1, and Skp1. Rbx1 binds the E2–ubiquitin conjugate. The target protein binds to an F-box protein that is bound to the enzyme core via interactions with the Skp1 subunit. After binding of a target protein to the F-box protein, the ubiquitin is transferred from E2 and attached via a peptide bond to a lysine side chain in the target protein. (b) A composite model structure for human SCF derived from X-ray structures of human Rbx1–Cul1–Skp1–Skp2 complex and the E2 enzyme Ubc7. The target protein (not shown here) interacts with the F-box protein Skp2, which thereby positions the substrate for ubiquitination by the E2 enzyme. Ubiquitin is not shown in this model but at the start of the reaction it would be bound to the E2 enzyme at the active-site cysteine shown in blue. (Adapted from Zheng, N. et al.: Nature 2002, 416:703–709.) (PDB 1fbv, 1ldk, 1fqr)
Hong Kong Museum of Art Chinese Antiquites Gallery