Deep Brain Stimulation (DBS) of Nucleus Basalis of Meynert (NBM) in Dementia with Lewy Bodies (DLB). NBM is one group of the basal forebrain cholinergic neurons (BFCN). The degeneration of BFCN is associated with decreased cholinergic tone and cognitive deficits in DLB. NBM provides cholinergic innervations to the entire neocortex. DBS of NBM likely enhances the cholinergic tone of neocortex, leading to improved cognitive function and quality of life. Potential disease modifying mechanisms include enhanced neurogenesis and increased nerve growth factor trophic support.