Original sentence: Cytochemical stains on blood and bone marrow smears must now be considered as largely non-informative and superseded by flow cytometry, cytogenetics and molecular biology.The diagnosis and classification of AML is usually straightforward when a multidisciplinary approach encompassing the above methods
Edited sentence: Cytochemical stains on blood and bone marrow smears are helpful in the distinction of AML from ALL and in subclassification of AML.In straightforward cases, the presence of certain morphologic features (such as Auer rods) or specific flow cytometry results can distinguish AML from other leukemias; however, in the absence of such features, diagnosis may be more difficult.The combination of a myeloperoxidase or Sudan black stain and a non specific esterase stain will provide the desired information in most cases.The diagnosis and classification of AML can be challenging, and should be performed by a qualified hematopathologist or hematologist.The myeloperoxidase or Sudan black reactions are most useful in establishing the identity of AML and distinguishing from ALL.The non-specific esterase stain is used to identify a monocytic component in AMLs and to distinguish a poorly differentiated monoblastic leukemia from ALL