Original sentence: Coarsening or thickening of the skin may also occur due to a build up of mucinous material within the skin (Mosby, 2007).Massage has been noted in the past to yield good results in at least preventing further advances of the malady (Art of Massage, Pg 42, Para 98).Myxedema (British English: myxoedema) describes a specific form of cutaneous and dermal edema secondary to increased deposition of connective tissues (like glycoaminoglycans, hyaluronic acid, and other mucopolysacccharides) as seen in various forms of hypothyroidism and Graves' disease.Myxedema originally was used to describe the clinical syndrome secondary to hypothyroidism.Myxedema typically presents in specific areas (pretibial myxedema and exophthalmos) and is related to high levels of TSH receptor stimulation and/or inflammation mounted against the TSH receptor itself.Oral administration of thyroxine may be prescribed by a doctor.Some of the basic signs and symptoms for Myxedema include Hoarse voice, fatigue, weight gain, cold intolerance, depression, restlessness, agitation, abdominal pain, and in some cases can lead to coma
Edited sentence: Hyperthyroid: Myxedema typically presents in specific areas (pretibial myxedema and exophthalmos) and is related to high levels of TSH receptor stimulation and/or inflammation mounted against the TSH receptor itself.Hypothyroid: Myxedema is also used to describe the clinical syndrome secondary to hypothyroidism.Myxedema (British English: myxoedema) describes a specific form of cutaneous and dermal edema secondary to increased deposition of connective tissues (like glycosaminoglycans, hyaluronic acid, and other mucopolysaccharides) as seen in various forms of hypothyroidism and Graves' disease.The term can be the cause of some confusion, because it can be used both in the context of hyperthyroid states and hypothyroid states