Original sentence: Given that the US recommendation is that prior BCG vaccination be ignored in the interpretation of tuberculin skin tests, false positives are possible as a result of: (1) people who have previously had BCG (even may years ago) may still have a false positive Mantoux test, and (2) serial testing with tuberculin skin tests boosts the immunological response in those people who have previously had BCG, so these people will falsely appear to be tuberculin converters.However, as Bacille_Calmette-Guérin vaccine is not 100% effective, and is less protective in adults than pediatric patients, not treating these patients could lead to a possible infection.The current US policy seems to a reflect a desire to err on the side of safety (of the general public).This may lead to treating more people than necessary, with the possible risk of those patients suffering adverse drug reactions
Edited sentence: Generally speaking, the U.In particular, U.There are major differences in the interpretation of tuberculin skin testing between the UK and the U.There are two reasons for this: (1) people who have previously had BCG (even many years ago) may still have a false positive Mantoux test, and (2) serial testing with tuberculin skin tests boosts the immunological response in those people who have previously had BCG, so these people will falsely appear to be tuberculin converters.guidance results in a much larger number of people being diagnosed with latent tuberculosis.recommendation is that prior BCG vaccination be ignored in the interpretation of tuberculin skin tests, which means that many more people (particularly foreign nationals who will almost all have had BCG) who have nothing wrong with them will end up having unnecessary treatment with potentially toxic drugs