Original sentence: A better understanding of evolvability is proposed to be part of an Extended Evolutionary Synthesis.Evolvability phenomena have practical applications.In protein engineering, both rational design and directed evolution approaches aim to create changes rapidly through mutations with large effects.More evolvable proteins can tolerate a broader range of amino acid changes and allow them to evolve toward new functions.Proteins are also often studied as part of the basic science of evolvability, because because biophysical properties and chemical functions can be easily changed by a few mutations.The study of evolvability has fundamental importance for understanding very long term evolution of protein superfamilies
Edited sentence: A thorough understanding of the details of long term evolution will likely form part of the Extended Evolutionary Synthesis (the update to the Modern Synthesis).Firstly, for protein engineering it is important to understand the factors that determine how much a protein function can be altered.In addition, these phenomena have two main practical applications.In particular, both rational design and directed evolution approaches aim to create changes rapidly through mutations with large effects.More evolvable proteins permit a broader range of amino acid changes and allow themto evolve toward new functions.Protein evolvability is often studied because because biophysical properties and chemical functions can be easily changed by a few mutations.The study of evolvability has fundamental importance for understanding very long term evolution of protein superfamilies and organism phyla and kingdoms