Edited sentence: A pharmacologically important aspect of the contraction-reducing properties of ingested Salvinorin A on gut tissue is that it is only pharmacologically active on inflamed and not normal tissue, thus reducing possible side-effects.Salvinorin A is capable of inhibiting excess intestinal motility (e.The mechanism of action for Salvinorin A on ileal tissue has been described as 'prejunctional', as it was able to modify electrically-induced contractions, but not those of exogenous acetylcholine.diarrhea), through a combination of k-opioid and cannabinoid (mainly CB1 receptor) receptors in inflamed but not normal gut in vivo]]