Original sentence: In alternative medicine a proposed medical condition, called leaky gut syndrome, has been popularized in which it is thought that substances migrate outward through the gut wall with adverse health consequences.In contrast to these mainstream medical scenarios, the existence of the condition commonly called "leaky gut syndrome" is supported mostly by nutritionists and practitioners of alternative medicine.In extreme cases the result can be ulcers in the bowel lining.It is accepted that various factors can affect the bowel's permeability, but the likely result of this is limited to temporary, mild, local inflammation.Leaky gut syndrome is not a recognized medical diagnosis, but a proposed condition that is claimed to be the root cause of many ailments, including chronic fatigue syndrome and multiple sclerosis.People with certain gut-related conditions such as Crohn's disease or inflammatory bowel disease may need treatment to reduce inflammation and maintain the health of their "leaky bowel".Quackwatch calls leaky gut a "fad diagnosis".Some skeptics and scientists say that the marketing of treatments for leaky gut syndrome is either misguided or an instance of deliberate health fraud.Stephen Barrett writes that its proponents use the alleged condition as an opportunity to promote a number of alternative health remedies including diets, herbal preparations, and dietary supplements
Edited sentence: Although intestinal permeability is a biological fact, leaky gut syndrome is not a recognized medical diagnosis, but a proposed condition that is claimed to be the root cause of many ailments, including chronic fatigue syndrome and multiple sclerosis.In alternative medicine a proposed medical condition, called leaky gut syndrome, has been popularized in which it is thought that numerous substances migrate outward through the gut wall with adverse health consequences.Intestinal tight junctions are affected in gut or intestinal permeability.It is accepted that various factors can affect the bowel's permeability.Researchers on gliadin (a class of proteins present in wheat) and zonulin concluded in 2006 that gliadin activates zonulin signaling irrespective of the genetic expression of autoimmunity, leading to increased intestinal permeability to macromolecules.Skeptics and some scientists say that the marketing of treatments for leaky gut syndrome is either misguided or an instance of deliberate health fraud.The existence of the condition commonly called "leaky gut syndrome" is supported mostly by nutritionists and practitioners of alternative medicine