Original sentence: Curcumin, which shows positive results in most drug discovery assays, is regarded as a false lead that medicinal chemists include among "pan-assay interference compounds" attracting undue experimental attention while failing to advance as viable therapeutic or drug leads.Factors that limit the bioactivity of curcumin or its analogs include chemical instability, water insolubility, absence of potent and selective target activity, low bioavailability, limited tissue distribution, extensive metabolism.If  curcumin were to enter plasma in reasonable amounts there would be a high risk of toxicity since it is promiscuous, and interacts with several proteins known to increase the risk of adverse effects, including hERG, cytochrome P450s, and glutathione S-transferase
Edited sentence: A 2017 article claimed that it was no more than a false lead that medicinal chemists include among "pan-assay interference compounds" and that it failed to advance as a viable therapeutic or drug lead.Curcumin shows positive results in many well-designed trials.Factors that limit the bioactivity of curcumin or its analogs include chemical instability, water insolubility, low bioavailability, limited tissue distribution, extensive metabolism.However, it has not led to profitable pharmaceutical products.If  curcumin were to enter plasma at high levels there could be a risk of toxicity since it is promiscuous, and interacts with several proteins known to increase the risk of adverse effects, including hERG, cytochrome P450s, and glutathione S-transferase.The culinary use of whole turmeric avoids that concern, and if consumed along with a lipid (as in the traditional cuisines of Asia), results in far better absorption of the curcumin, in amounts that have little risk of side effects