Edited sentence: A painful tongue may be an indication of several underlying serious medical conditions and nearly always merits assessment by a doctor or dentist.Administration of ganglion blockers (eg.Allergic reaction to toothpaste, mouthwash, breath fresheners, dyes in candy, plastic in dentures or retainers, or certain blood-pressure medications (ACE inhibitors).Bacterial or viral infections (including oral herpes simplex).Disorders such as iron deficiency anemia, pernicious anemia and other B-vitamin deficiencies, oral lichen planus, erythema multiforme, aphthous ulcer, pemphigus vulgaris, syphilis, and others.Exposure to irritants such as tobacco, alcohol, hot foods, or spices.Mechanical irritation or injury from burns, rough edges of teeth or dental appliances, or other trauma.Occasionally, glossitis can be inherited.Poor hydration and low saliva in the mouth may allow bacteria to grow more readily.Tongue Piercings.Tubocurarine, Mecamylamine)