Edited sentence: Put simply, histidine kinases phosphorylate aspartic acid residues.Rather, a histidine is used by the histidine kinase to transfer the phosphate to the substrate's aspartic acid residue.The histidine residue is not the final destination of the phosphate as the name might suggest.This is a common point of confusion.To my knowledge, this term would be used to describe a histidine kinase.While serine, threonine, and tyrosine kinases transfer phosphate from a molecule of ATP to a serine, threonine, or tyrosine, histidine kinases work differently