Original sentence: A small clinical trial conducted at Harvard Medical School in 1995, demonstrated that a majority of treatment-refractory, unipolar, non-psychotic, major depression patients could be successfully treated with an opioid medication called Buprenorphine, which is a partial mu agonist and potent kappa antagonist.After the release of this paper, use of buprenorphine against depression in the clinical setting has increased.Opium has long been known as an antidepressant.The exact mechanism of its action in depression is not known, as kappa antagonists are antidepressants in their own right.The lack of large-scale clinical trials has been a deterrent to widespread use.Various Opiates were commonly used as antidepressants until the mid-1950s, when they fell out of favor with medical orthodoxy due to their addictive nature, the tolerance buildup issues and their side-effect profile.While opioids have been proven to substantially relieve symptoms of depression for a large class of patients, re-acceptance of this fact has been severely hampered by governmental narcotic prohibition efforts, and the (until buprenorphine) lack of alternatives with low risk of tolerance and addiction
Edited sentence: A clinical trial conducted at Harvard Medical School in 1995, demonstrated that a majority of treatment-refractory, unipolar, non-psychotic, major depression patients could be successfully treated with an opioid medication called Buprenorphine.Opium has been known as an antidepressant since Biblical times.Various Opiates were commonly used as antidepressants until the mid-1950s, when they fell out of favor with medical orthodoxy due to their addictive nature.While opioids have been proven to substantially relieve symptoms of depression, re-acceptance of this fact has been severely hampered by governmental narcotic prohibition efforts