Original sentence: , lung) and recent surgery (within 30 days before drotrecogin use) have had a higher mortalitity rate in the ADDRESS study.A recent study in pediatric patients with severe sepsis had to be discontinued (lack of positive results and severe side-effects).Clinicians should consider continuing prophylactic heparin at time of institution of Xigris infusion unless discontinuation of prophylactic heparin is considered medically necessary.Eli Lilly has recently issued 3 important additional warnings:.Patients with single organ dysfunction due to sepsis (e.Treatment of these patient subgroup cannot be recommended and are generally considered non-indicated population