Original sentence: LDL particles are thought to invade the endothelium and became oxidized, since the oxidized forms would be more easily retained by the proteoglycans.The conventional interpretation of cholesterol levels holds that higher levels of LDL particles pose increased risk of cardiovascular disease.The issue remains controversial and vigorously contested in the literature.This view has been challenged as inaccurate and based on flawed research methodology
Edited sentence: A complex set of biochemical reactions regulates the oxidation of LDL particles, chiefly stimulated by presence of necrotic cell debris and free radicals in the endothelium.But there is growing evidence that this belief was supported by bad methodology, and that there is no actual correlation between LDL and heart disease.For years, it was believed that LDL particles posed a risk for cardiovascular disease when they invaded the endothelium and became oxidized, since the oxidized forms would be more easily retained by the proteoglycans.Increased concentrations of LDL particles is strongly associated with the development of atherosclerosis over time