Original sentence: Although his research had failed to yield the desired result, Koe was convinced that the development of a viable anti-depressant was within reach.Apparently neuroleptic chlorprothixene is the predecessor to tametraline.During his 40 years at Pfizer, Koe authored more than 100 articles and papers.HCl by another chemist, Willard Welch.In his early work with serotonin, for example, he studied the chemical tametraline, which proved ineffective as an anti-depressant.Koe learned to review previous studies and to build on findings that had failed to lead to successful products.Tametraline is a catecholamine reuptake inhibitor, and was never marketed due to its undesired stimulant effects.Tametraline is the parent of a series of chemical compounds investigated by Kenneth Ko at Pfizer that eventually led to the development of Zoloft® = (SS)-dichlorotametraline.Tests showed the chemical functioned more as a stimulant, a use Pfizer was not interested in pursuing
Edited sentence: Tametraline is a catecholamine reuptake inhibitor, but was never marketed due to its undesired stimulant effects - which stand in sharp contrast to the major tranquilizer (antipsychotic) effects of neuroleptic chlorprothixene, from which its structure was conceived.Tametraline is the parent of a series of chemical compounds investigated by Kenneth Ko at Pfizer that eventually led to the development of Sertraline (Zoloft) (3,4-dichloro tametraline) by another chemist, Willard Welch