Edited sentence: After ongoing disputes with the Commonwealth Department of Health and its director, (John) Howard Cumpston, Penfold resigned in 1927 and was replaced by Frederic Morgan.Although CSL's manufacturing processes were absolved, its labelling procedures were seen to be in error, leading to an enduring focus on the highest standards across the facility's production.In 1928 CSL also became involved in antivenene antivenom manufacture in conjunction with the snake venom research undertaken by Charles Kellaway at the Hall Institute.In 1934 the research on snake venoms was transferred from the Hall Institute to CSL under the direction of former snake showman, Tom 'Pambo' Eades.Keogh played an important role in the establishment of penicillin production at CSL in 1944 - a critical wartime achievement.Much of this work, including the introduction in 1962 of a polyvalent antivenom against all of the major terrestrial Australian snakes, occurred under the direction of Saul Wiener, while from 1966 until the mid-1990s, venom research was coordinated by the eccentric but dedicated Struan Sutherland.Soon after Morgan's appointment, CSL was drawn into a serious public health disaster when a batch of its diphtheria toxin-antitoxin was implicated in the deaths of 12 children in what became known as the 'Bundaberg tragedy of 1928.The relationship with the Hall Institute continued until World War II, particularly via joint projects on viral diseases including polio and influenza coordinated by Frank Macfarlane Burnet and Esmond 'Bill' Keogh.Thereafter the range of antivenoms increased, including those against other snake species such as death adder Acanthophis antarcticus and the taipan Oxyuranus scutellatus, plus spiders including the redback Latrodectus hasselti and - after much difficulty - the Sydney funnnel-web Atrax robustus.This led to the successful clinical testing of antivenene against tiger snake Notechis scutatus bite in 1930, and its commercial release in 1931.This represented the initiation of research at the Laboratories - an outcome its directors had been seeking for over a decade.Under the first director, Australian-born William Penfold, CSL commenced operation in the vacant Walter and Eliza Hall Institute building at the Melbourne Hospital in 1918, before moving to its purpose-built Parkville premises in the following year