Original sentence: Chemical biology cannot continue to overlook the existence of polypharmacology and its urge to become a more holistic discipline that looks at the use of tool compounds from a systems perspective.Despite scientific advancements and an increase of global R&D spending, drugs are frequently withdrawn from markets.Drug molecules often interact with multiple targets and the unintended drug-target interactions can cause side-effects.Polypharmacology remains to be one of the major challenges in drug development, and it opens novel avenues to rationally design the next generation of more effective but less toxic therapeutic agents
Edited sentence: Chemical biology cannot continue to overlook the existence of polypharmacology and it urge to become a more holistic discipline that looks at the use of tool compounds from a systems perspective.Drug molecules often interact with multiple targets and the unintended drug-target interactions could cause side-effects.In recent years even with remarkable scientific advancements and significant increase of global R&D spending, drugs are frequently withdrawn from markets.Polypharmacology remains to be one of the major challenges in drug development, and it opens novel avenues to rationally design next generation of more effective but less toxic therapeutic agents