Original sentence: In this study, patients receiving olanzapine had a lower risk of progressing to psychosis, although the difference did not reach statistical significance.Olanzapine was effective for treating the prodromal symptoms, but was associated with significant weight gain.The Prevention through Risk Identification, Management, and Education (PRIME) study, funded by the National Institute of Mental Health and Eli Lilly, tested the hypothesis that olanzapine might prevent the onset of psychosis in people at very high risk for schizophrenia.The study examined 60 patients with prodromal schizophrenia, who were at an estimated risk of 36%–54% of developing schizophrenia within a year, and treated half with olanzapine and half with placebo
Edited sentence: A controversial experiment, Prevention through Risk Identification, Management, and Education (PRIME), was initiated by Dr.Absent a diagnosable condition, and absent any evidence to support the assumption that a drug can prevent schizophrenia, these healthy youngsters were exposed to a toxic drug on the basis of speculations.Alan Breier, Vice President and Medical and Chief Medical Officer for Eli Lilly was involved in the PRIME project and was one of the chief medical authors of the clinical trials.From 1997 to 2003, sixty previously healthy youngsters were enrolled in the experiment:  of whom half were exposed to Zyprexa (olanzapine), a drug so toxic it is now costing Eli Lilly over a billion dollars in lawsuit settlements.None of the youngsters in PRIME met the diagnostic criteria of either condition for which the drug was approved.PRIME investigators tested a speculative schizophrenia prevention theory by exposing healthy youngsters for one year to Lilly’s toxic blockbuster drug, the neuroleptic, Zyprexa (olanzapine).Prior to joining Lilly, Breier completed a three-year research fellowship at NIMH.The authors now acknowledge in their published report that the experiment had failed and that Zyprexa did not prevent schizophrenia.Thomas McGlashan of Yale University, and director of the National Institute for Mental Health (NIMH), with funding from Eli Lilly and the NIMH