Edited sentence: ) appear less toxic and more hallucinogenic.Because bufotenin acts on both central and peripheral 5-HT receptors, as expected, tests preformed with more water soluble derivatives of bufotenin appear more toxic and less hallucinogenic in humans while more lipid soluble forms (free base bufotenin, calcium bufotenate, etc.Bufotenin acts on both central and peripheral 5-HT receptors.Human toxicity and pharmacological activity varies by route of administration and form of bufotenin.In contrast, tests conducted using other (i.More lipid soluble forms cross the blood brain barrier more effectively and are able to act on central 5-HT receptors in the brain, producing more psychoactive effects.Studies by Glennon and colleagues (1979) showed the pivalate and acetate esters of bufotenin had more lipid solubility than bufotenin.Tests performed via intravenous injections of highly water soluble bufotenin creatinine sulfate salt in doses as little as 2 mg have shown toxic bodily symptoms: nausea, tightness in the throat and stomach, tingling in the body, purplish hue developing in the face, pain in the thighs, tension in the chest, as well as pins and needles in the face with little signs of hallucinogenic activity.Water soluble forms do not cross the blood brain barrier effectively and primarily act on peripheral 5-HT receptors producing toxic symptoms in the body.non-systemic) routes of administration of the more lipid soluble free base bufotenin in several subjects have shown it to elicit strong hallucinogenic effects with no discomfort or disesteeming side-effects