Original sentence: GlaxoSmithKline claimed that the M184V mutation reduces "viral fitness", because of the finding that continued lamivudine treatment causes the HIV viral load to rebound but at a much lower level, and that withdrawal of lamivudine results in a higher viral load rebound with rapid loss of the M184V mutation; GSK therefore argued that there may be benefit in continuing lamivudine treatment even in the presence of high level resistance, because the resistant virus is "less fit".The COLATE study has suggested that there is no benefit to continuing lamivudine treatment in patients with lamivudine resistance
Edited sentence: GlaxoSmithKline sought to perpetuate the fiction that the M184V mutation reduces "viral fitness", because of the finding that continued lamivudine treatment causes the HIV viral load to rebound but at a much lower level, and that withdrawal of lamivudine results in a higher viral load rebound with rapid loss of the M184V mutation; GSK therefore argued that there is theoretical benefit in continuing lamivudine treatment even in the presence of high level resistance, because the resistant virus is "less fit".The COLATE study has shown definitively that there is no benefit to continuing lamivudine treatment in patients with lamivudine resistance