Original sentence: " Here again, the problem of induction plays a key role in arguments.For example, if an older generic statin drug has been shown to reduce mortality, is it enough that a newer but much more expensive statin drug lowers cholesterol more effectively, even if mortality reductions have not had enough time to be shown.If a new, costly therapy that works on tumor blood vessels causes two kinds of cancer to go into remission, is it justified as an expense in a third kind of cancer, before this has specifically been proven.In some cases, these denials were based upon questions of induction and efficacy as discussed above.Insurance companies use evidence-based guidelines sometimes as a basis for denying coverage for a treatment held by the physicians involved to be effective, but for which randomized controlled trials have not yet been published.Kaiser Permanente did not change its methods of evaluating whether or not new therapies were too "experimental" to be covered until it was successfully sued twice: once for delaying IVF treatments for two years after the courts determined that scientific evidence of efficacy and safety had reached the "reasonable" stage; and in another case where Kaiser refused to pay for liver transplantation in infants when it had already been shown to be effective in adults, on the basis that use in infants was still "experimental