fenil210/Med-Lamma huggingface dataset:
Is Retinoblastoma inherited ?
Retinoblastoma occurs in heritable and nonheritable forms.
                    A child is thought to have the heritable form of retinoblastoma when one of the following is true:         - There is a family history of retinoblastoma.    - There is a certain mutation (change) in the RB1 gene. The mutation in the RB1 gene may be passed from the parent to the child or it may occur in the egg or sperm before conception or soon after conception.    - There is more than one tumor in the eye or there is a tumor in both eyes.    - There is a tumor in one eye and the child is younger than 1 year.        After heritable retinoblastoma has been diagnosed and treated, new tumors may continue to form for a few years. Regular eye exams to check for new tumors are usually done every 2 to 4 months for at least 28 months.    Nonheritable retinoblastoma is retinoblastoma that is not the heritable form. Most cases of retinoblastoma are the nonheritable form.
                
                
                    Treatment for both forms of retinoblastoma should include genetic counseling.
                    Parents should receive genetic counseling (a discussion with a trained professional about the risk of genetic diseases) to discuss genetic testing to check for a mutation (change) in the RB1 gene. Genetic counseling also includes a discussion of the risk of retinoblastoma for the child and the child's brothers or sisters.
                
                
                    Children with a family history of retinoblastoma should have eye exams to check for retinoblastoma.
                    A child with a family history of retinoblastoma should have regular eye exams beginning early in life to check for retinoblastoma, unless it is known that the child does not have the RB1 gene change. Early diagnosis of retinoblastoma may mean the child will need less intense treatment.   Brothers or sisters of a child with retinoblastoma should have regular eye exams by an ophthalmologist until age 3 to 5 years, unless it is known that the brother or sister does not have the RB1 gene change.
                
                
                    A child who has heritable retinoblastoma has an increased risk of trilateral retinoblastoma and other cancers.
                    A child with heritable retinoblastoma has an increased risk of a pineal tumor in the brain. When retinoblastoma and a brain tumor occur at the same time, it is called trilateral retinoblastoma. The brain tumor is usually diagnosed between 20 and 36 months of age. Regular screening using MRI (magnetic resonance imaging) may be done for a child thought to have heritable retinoblastoma or for a child with retinoblastoma in one eye and a family history of the disease. CT (computerized tomography) scans are usually not used for routine screening in order to avoid exposing the child to ionizing radiation.    Heritable retinoblastoma also increases the child's risk of other types of cancer such as lung cancer, bladder cancer, or melanoma in later years. Regular follow-up exams are important. + CancerGov + Retinoblastoma
Who is at risk for Retinoblastoma? ?
A child who has heritable retinoblastoma has an increased risk of trilateral retinoblastoma and other cancers. A child with heritable retinoblastoma has an increased risk of a pineal tumor in the brain. When retinoblastoma and a brain tumor occur at the same time, it is called trilateral retinoblastoma. The brain tumor is usually diagnosed between 20 and 36 months of age. Regular screening using MRI (magnetic resonance imaging) may be done for a child thought to have heritable retinoblastoma or for a child with retinoblastoma in one eye and a family history of the disease. CT (computerized tomography) scans are usually not used for routine screening in order to avoid exposing the child to ionizing radiation.    Heritable retinoblastoma also increases the child's risk of other types of cancer such as lung cancer, bladder cancer, or melanoma in later years. Regular follow-up exams are important. + CancerGov + Retinoblastoma
What are the symptoms of Retinoblastoma ?
These and other signs and symptoms may be caused by retinoblastoma or by other conditions. Check with a doctor if your child has any of the following:         -  Pupil of the eye appears white instead of red when light shines into it. This may be seen in flash photographs of the child.    - Eyes appear to be looking in different directions (lazy eye).    - Pain or redness in the eye.    -  Infection around the eye.     - Eyeball is larger than normal.     - Colored part of the eye and pupil look cloudy. + CancerGov + Retinoblastoma
How to diagnose Retinoblastoma ?
The following tests and procedures may be used:         -   Physical exam and history : An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patients health habits and past illnesses and treatments will also be taken. The doctor will ask if there is a family history of retinoblastoma.    -  Eye exam with dilated pupil: An exam of the eye in which the pupil is dilated (opened wider) with medicated eye drops to allow the doctor to look through the lens and pupil to the retina. The inside of the eye, including the retina and the optic nerve, is examined with a light. Depending on the age of the child, this exam may be done under anesthesia. There are several types of eye exams that are done with the pupil dilated:               -  Ophthalmoscopy : An exam of the inside of the back of the eye to check the retina and optic nerve using a small magnifying lens and a light.      -  Slit-lamp biomicroscopy : An exam of the inside of the eye to check the retina, optic nerve, and other parts of the eye using a strong beam of light and a microscope.      - Fluorescein angiography : A procedure to look at blood vessels and the flow of blood inside the eye. An orange fluorescent dye called fluorescein is injected into a blood vessel in the arm and goes into the bloodstream. As the dye travels through blood vessels of the eye, a special camera takes pictures of the retina and choroid to find any blood vessels that are blocked or leaking.              -   RB1 gene test: A laboratory test in which a sample of blood or tissue is tested for a change in the RB1 gene.    -   Ultrasound exam of the eye: A procedure in which high-energy sound waves (ultrasound) are bounced off the internal tissues of the eye to make echoes. Eye drops are used to numb the eye and a small probe that sends and receives sound waves is placed gently on the surface of the eye. The echoes make a picture of the inside of the eye and the distance from the cornea to the retina is measured. The picture, called a sonogram, shows on the screen of the ultrasound monitor. The picture can be printed to be looked at later.    -  MRI (magnetic resonance imaging): A procedure that uses a magnet, radio waves, and a computer to make a series of detailed pictures of areas inside the body, such as the eye. This procedure is also called nuclear magnetic resonance imaging (NMRI).    -  CT scan (CAT scan): A procedure that makes a series of detailed pictures of areas inside the body, such as the eye, taken from different angles. The pictures are made by a computer linked to an x-ray machine. A dye may be injected into a vein or swallowed to help the organs or tissues show up more clearly. This procedure is also called computed tomography, computerized tomography, or computerized axial tomography.        Retinoblastoma can usually be diagnosed without a biopsy.   When retinoblastoma is in one eye, it sometimes forms in the other eye. Exams of the unaffected eye are done until it is known if the retinoblastoma is the heritable form. + CancerGov + Retinoblastoma
What is the outlook for Retinoblastoma ?
The prognosis (chance of recovery) and treatment options depend on the following:         - Whether the cancer is in one or both eyes.    - The size and number of tumors.    - Whether the tumor has spread to the area around the eye, to the brain, or to other parts of the body.    - Whether there are symptoms at the time of diagnosis, for trilateral retinoblastoma.    - The age of the child.    - How likely it is that vision can be saved in one or both eyes.    - Whether a second type of cancer has formed. + CancerGov + Retinoblastoma
what research (or clinical trials) is being done for Retinoblastoma ?
New types of treatment are being tested in clinical trials.
                    Information about clinical trials is available from the NCI website.
                
                
                    Patients may want to think about taking part in a clinical trial.
                    For some patients, taking part in a clinical trial may be the best treatment choice. Clinical trials are part of the cancer research process. Clinical trials are done to find out if new cancer treatments are safe and effective or better than the standard treatment.   Many of today's standard treatments for cancer are based on earlier clinical trials. Patients who take part in a clinical trial may receive the standard treatment or be among the first to receive a new treatment.   Patients who take part in clinical trials also help improve the way cancer will be treated in the future. Even when clinical trials do not lead to effective new treatments, they often answer important questions and help move research forward.
                
                
                    Patients can enter clinical trials before, during, or after starting their cancer treatment.
                    Some clinical trials only include patients who have not yet received treatment. Other trials test treatments for patients whose cancer has not gotten better. There are also clinical trials that test new ways to stop cancer from recurring (coming back) or reduce the side effects of cancer treatment.   Clinical trials are taking place in many parts of the country. See the Treatment Options section that follows for links to current treatment clinical trials. These have been retrieved from NCI's listing of clinical trials. + CancerGov + Retinoblastoma
What is (are) Childhood Acute Lymphoblastic Leukemia ?
Key Points
                    - Childhood acute lymphoblastic leukemia (ALL) is a type of cancer in which the bone marrow makes too many immature lymphocytes (a type of white blood cell).    - Leukemia may affect red blood cells, white blood cells, and platelets.    - Past treatment for cancer and certain genetic conditions affect the risk of having childhood ALL.    - Signs of childhood ALL include fever and bruising.    - Tests that examine the blood and bone marrow are used to detect (find) and diagnose childhood ALL.    - Certain factors affect prognosis (chance of recovery) and treatment options.
                 
                
                    Childhood acute lymphoblastic leukemia (ALL) is a type of cancer in which the bone marrow makes too many immature lymphocytes (a type of white blood cell).
                    Childhood acute lymphoblastic leukemia (also called ALL or acute lymphocytic leukemia) is a cancer of the blood and bone marrow. This type of cancer usually gets worse quickly if it is not treated.     ALL is the most common type of cancer in children.
                
                
                    Leukemia may affect red blood cells, white blood cells, and platelets.
                    In a healthy child, the bone marrow makes blood stem cells (immature cells) that become mature blood cells over time. A blood stem cell may become a myeloid stem cell or a lymphoid stem cell.   A myeloid stem cell becomes one of three types of mature blood cells:         -  Red blood cells that carry oxygen and other substances to all tissues of the body.    -  Platelets that form blood clots to stop bleeding.    -  White blood cells that fight infection and disease.         A lymphoid stem cell becomes a lymphoblast cell and then one of three types of lymphocytes (white blood cells):         -  B lymphocytes that make antibodies to help fight infection.    -  T lymphocytes that help B lymphocytes make the antibodies that help fight infection.    -  Natural killer cells that attack cancer cells and viruses.         In a child with ALL, too many stem cells become lymphoblasts, B lymphocytes, or T lymphocytes. The cells do not work like normal lymphocytes and are not able to fight infection very well. These cells are cancer (leukemia) cells. Also, as the number of leukemia cells increases in the blood and bone marrow, there is less room for healthy white blood cells, red blood cells, and platelets. This may lead to infection, anemia, and easy bleeding.   This summary is about acute lymphoblastic leukemia in children, adolescents, and young adults. See the following PDQ summaries for information about other types of leukemia:         -  Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies Treatment     -  Adult Acute Lymphoblastic Leukemia Treatment     -  Chronic Lymphocytic Leukemia Treatment     -  Adult Acute Myeloid Leukemia Treatment     -  Chronic Myelogenous Leukemia Treatment     -  Hairy Cell Leukemia Treatment + CancerGov + Childhood Acute Lymphoblastic Leukemia
What are the symptoms of Childhood Acute Lymphoblastic Leukemia ?
Signs of childhood ALL include fever and bruising. These and other signs and symptoms may be caused by childhood ALL or by other conditions. Check with your child's doctor if your child has any of the following:         -  Fever.    - Easy bruising or bleeding.    -  Petechiae (flat, pinpoint, dark-red spots under the skin caused by bleeding).    - Bone or joint pain.    - Painless lumps in the neck, underarm, stomach, or groin.    - Pain or feeling of fullness below the ribs.    - Weakness, feeling tired, or looking pale.    - Loss of appetite. + CancerGov + Childhood Acute Lymphoblastic Leukemia
What is the outlook for Childhood Acute Lymphoblastic Leukemia ?
Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery) depends on:         - How quickly and how low the leukemia cell count drops after the first month of treatment.    - Age at the time of diagnosis, gender, race, and ethnic background.    - The number of white blood cells in the blood at the time of diagnosis.    - Whether the leukemia cells began from B lymphocytes or T lymphocytes.    - Whether there are certain changes in the chromosomes or genes of the lymphocytes with cancer.    - Whether the child has Down syndrome.    - Whether leukemia cells are found in the cerebrospinal fluid.    - The child's weight at the time of diagnosis and during treatment.        Treatment options depend on:         - Whether the leukemia cells began from B lymphocytes or T lymphocytes.    - Whether the child has standard-risk, high-risk, or very highrisk ALL.    - The age of the child at the time of diagnosis.    - Whether there are certain changes in the chromosomes of lymphocytes, such as the Philadelphia chromosome.    - Whether the child was treated with steroids before the start of induction therapy.    - How quickly and how low the leukemia cell count drops during treatment.        For leukemia that relapses (comes back) after treatment, the prognosis and treatment options depend partly on the following:         - How long it is between the time of diagnosis and when the leukemia comes back.    - Whether the leukemia comes back in the bone marrow or in other parts of the body. + CancerGov + Childhood Acute Lymphoblastic Leukemia
what research (or clinical trials) is being done for Childhood Acute Lymphoblastic Leukemia ?
New types of treatment are being tested in clinical trials.
                    This summary section describes treatments that are being studied in clinical trials. It may not mention every new treatment being studied. Information about clinical trials is available from the NCI website.     Chimeric antigen receptor (CAR) T-cell therapy     CAR T-cell therapy is a type of immunotherapy that changes the patient's T cells (a type of immune system cell) so they will attack certain proteins on the surface of cancer cells. T cells are taken from the patient and special receptors are added to their surface in the laboratory. The changed cells are called chimeric antigen receptor (CAR) T cells. The CAR T cells are grown in the laboratory and given to the patient by infusion. The CAR T cells multiply in the patient's blood and attack cancer cells. CAR T-cell therapy is being studied in the treatment of childhood ALL that has relapsed (come back) a second time.
                
                
                    Patients may want to think about taking part in a clinical trial.
                    For some patients, taking part in a clinical trial may be the best treatment choice. Clinical trials are part of the cancer research process. Clinical trials are done to find out if new cancer treatments are safe and effective or better than the standard treatment.   Many of today's standard treatments for cancer are based on earlier clinical trials. Patients who take part in a clinical trial may receive the standard treatment or be among the first to receive a new treatment.   Patients who take part in clinical trials also help improve the way cancer will be treated in the future. Even when clinical trials do not lead to effective new treatments, they often answer important questions and help move research forward.
                
                
                    Patients can enter clinical trials before, during, or after starting their cancer treatment.
                    Some clinical trials only include patients who have not yet received treatment. Other trials test treatments for patients whose cancer has not gotten better. There are also clinical trials that test new ways to stop cancer from recurring (coming back) or reduce the side effects of cancer treatment.   Clinical trials are taking place in many parts of the country. See the Treatment Options section that follows for links to current treatment clinical trials. These have been retrieved from NCI's listing of clinical trials. + CancerGov + Childhood Acute Lymphoblastic Leukemia
Who is at risk for Childhood Acute Lymphoblastic Leukemia? ?
Key Points
                    Past treatment for cancer and certain genetic conditions affect the risk of having childhood ALL. Anything that increases your risk of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesnt mean that you will not get cancer. Talk with your child's doctor if you think your child may be at risk.    Possible risk factors for ALL include the following:         - Being exposed to x-rays before birth.    - Being exposed to radiation.    - Past treatment with chemotherapy.    - Having certain genetic conditions, such as:               -  Down syndrome.      -  Neurofibromatosis type 1.      -  Bloom syndrome.      -  Fanconi anemia.      -  Ataxia-telangiectasia.      -  Li-Fraumeni syndrome.      - Constitutional mismatch repair deficiency (mutations in certain genes that stop DNA from repairing itself, which leads to the growth of cancers at an early age).             - Having certain changes in the chromosomes or genes.
                       
                
                    Risk Groups
                    - In childhood ALL, risk groups are used to plan treatment.    - Relapsed childhood ALL is cancer that has come back after it has been treated.
                
                
                
                    In childhood ALL, risk groups are used to plan treatment.
                    There are three risk groups in childhood ALL. They are described as:         - Standard (low) risk: Includes children aged 1 to younger than 10 years who have a white blood cell count of less than 50,000/L at the time of diagnosis.    - High risk: Includes children 10 years and older and/or children who have a white blood cell count of 50,000/L or more at the time of diagnosis.    - Very high risk: Includes children younger than age 1, children with certain changes in the genes, children who have a slow response to initial treatment, and children who have signs of leukemia after the first 4 weeks of treatment.        Other factors that affect the risk group include the following:         - Whether the leukemia cells began from B lymphocytes or T lymphocytes.    - Whether there are certain changes in the chromosomes or genes of the lymphocytes.    - How quickly and how low the leukemia cell count drops after initial treatment.    - Whether leukemia cells are found in the cerebrospinal fluid at the time of diagnosis.        It is important to know the risk group in order to plan treatment. Children with high-risk or very highrisk ALL usually receive more anticancer drugs and/or higher doses of anticancer drugs than children with standard-risk ALL.
                
                
                
                    Relapsed childhood ALL is cancer that has come back after it has been treated.
                    The leukemia may come back in the blood and bone marrow, brain, spinal cord, testicles, or other parts of the body.    Refractory childhood ALL is cancer that does not respond to treatment. + CancerGov + Childhood Acute Lymphoblastic Leukemia
Who is at risk for Childhood Liver Cancer? ?
Certain diseases and disorders can increase the risk of childhood liver cancer. Anything that increases your chance of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesnt mean that you will not get cancer. Talk with your childs doctor if you think your child may be at risk.    Risk factors for hepatoblastoma include the following syndromes or conditions:         -  Aicardi syndrome.    -  Beckwith-Wiedemann syndrome.    -  Familial adenomatous polyposis (FAP).    -  Glycogen storage disease.    - A very low weight at birth.    - Simpson-Golabi-Behmel syndrome.    - Certain genetic changes, such as Trisomy 18.        Risk factors for hepatocellular carcinoma include the following syndromes or conditions:         -  Alagille syndrome.    -  Glycogen storage disease.    -  Hepatitis B virus infection that was passed from mother to child at birth.    -  Progressive familial intrahepatic disease.    -  Tyrosinemia.        Some patients with tyrosinemia or progressive familial intrahepatic disease will have a liver transplant before there are signs or symptoms of cancer. + CancerGov + Childhood Liver Cancer
What are the symptoms of Childhood Liver Cancer ?
Signs and symptoms of childhood liver cancer include a lump or pain in the abdomen. Signs and symptoms are more common after the tumor gets big. Other conditions can cause the same signs and symptoms. Check with your childs doctor if your child has any of the following:         - A lump in the abdomen that may be painful.    - Swelling in the abdomen.    - Weight loss for no known reason.    - Loss of appetite.    -  Nausea and vomiting. + CancerGov + Childhood Liver Cancer