James W. Huffman
 James Wylie Huffman (September 13 1894 – May 20 1980) was a Democratic Party politician from Ohio. He represented Ohio in the United States Senate from 1945 until 1946.Born in Chandlersville Muskingum County Ohio Huffman graduated from law school at the University of Chicago in 1922 and began practicing law in Illinois. He returned to Ohio a year later. In 1944 Huffman ran for the Democratic nomination for Ohio governor but he came in third.