William Case
 William Case (August 10 1818 – April 19 1862) was an American politician of the Republican party and served as the 12th mayor of Cleveland Ohio from 1850 and 1851. He was the first Cleveland-born citizen to become mayor.In his early career he helped form and became the first president of the Cleveland Library Association in 1846 (later the Case Library). In 1850 he founded the short-lived Cleveland University.