German submarine U-543
 German submarine U-543 was a Type IXC U-boat of Nazi Germany's Kriegsmarine during World War II.She was laid down at the Deutsche Werft (yard) in Hamburg as 'werk' 364 on 3 July 1942 launched on 3 February and commissioned on 21 April with Kapitänleutnant Hans-Jürgen Hellriegel in command.U-543 began her service career with training as part of the 4th U-boat Flotilla from 21 April 1943.