Cape Girardeau Commercial Historic District
 Cape Girardeau Commercial Historic District is a historic district in Cape Girardeau Missouri. It was listed on the National Register of Historic Places in 2000.In 2000 the area listed was 1.6 acres (0.65 ha) and included 17 contributing buildings. In a first increase an 1891 contributing building at 101 N. Main St. was added. The building was designed by Jerome B. Legg and Henry Ossenkop in Romanesque style. In a second increase three contributing buildings dating from 1870 were added.