James Patton Preston
 James Patton Preston (June 21 1774 – May 4 1843) was a U.S. political figure. He was born at Smithfield Plantation in what is now Blacksburg Virginia and was the brother-in-law of John Floyd and the uncle of James McDowell and John Buchanan Floyd. His father was Colonel William Preston. James Patton Preston was wounded at the Battle of Crysler's Farm in Ontario during the War of 1812.