Topic: Kaposi Sarcoma
Question: What is (are) Kaposi Sarcoma ?
Answer: Key Points
                    - Kaposi sarcoma is a disease in which malignant tumors (cancer) can form in the skin, mucous membranes, lymph nodes, and other organs.    - Tests that examine the skin, lungs, and gastrointestinal tract are used to detect (find) and diagnose Kaposi sarcoma.    - After Kaposi sarcoma has been diagnosed, tests are done to find out if cancer cells have spread to other parts of the body.    - Certain factors affect prognosis (chance of recovery) and treatment options.
                
                
                    Kaposi sarcoma is a disease in which malignant tumors (cancer) can form in the skin, mucous membranes, lymph nodes, and other organs.
                    Kaposi sarcoma is a cancer that causes lesions (abnormal tissue) to grow in the skin; the mucous membranes lining the mouth, nose, and throat; lymph nodes; or other organs. The lesions are usually purple and are made of cancer cells, new blood vessels, red blood cells, and white blood cells. Kaposi sarcoma is different from other cancers in that lesions may begin in more than one place in the body at the same time.    Human herpesvirus-8 (HHV-8) is found in the lesions of all patients with Kaposi sarcoma. This virus is also called Kaposi sarcoma herpesvirus (KSHV). Most people infected with HHV-8 do not get Kaposi sarcoma. Those infected with HHV-8 who are most likely to develop Kaposi sarcoma have immune systems weakened by disease or by drugs given after an organ transplant.   There are several types of Kaposi sarcoma, including:         -  Classic Kaposi sarcoma.    -  African Kaposi sarcoma.    -  Immunosuppressive therapyrelated Kaposi sarcoma.    -  Epidemic Kaposi sarcoma.    -  Nonepidemic Kaposi sarcoma.
                
                
                    Tests that examine the skin, lungs, and gastrointestinal tract are used to detect (find) and diagnose Kaposi sarcoma.
                    The following tests and procedures may be used:         -   Physical exam and history : An exam of the body to check general signs of health, including checking skin and lymph nodes for signs of disease, such as lumps or anything else that seems unusual. A history of the patient's health habits and past illnesses and treatments will also be taken.    -   Chest x-ray : An x-ray of the organs and bones inside the chest. An x-ray is a type of energy beam that can go through the body and onto film, making a picture of areas inside the body. This is used to find Kaposi sarcoma in the lungs.    -   Biopsy : The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer.  One of the following types of biopsies may be done to check for Kaposi sarcoma lesions in the skin:               -  Excisional biopsy : A scalpel is used to remove the entire skin growth.       -  Incisional biopsy : A scalpel is used to remove part of a skin growth.      -  Core biopsy : A wide needle is used to remove part of a skin growth.      -  Fine-needle aspiration (FNA) biopsy : A thin needle is used to remove part of a skin growth.          An endoscopy or bronchoscopy may be done to check for Kaposi sarcoma lesions in the gastrointestinal tract or lungs.               - Endoscopy for biopsy: A procedure to look at organs and tissues inside the body to check for abnormal areas. An endoscope is inserted through an incision (cut) in the skin or opening in the body, such as the mouth. An endoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a tool to remove tissue or lymph node samples, which are checked under a microscope for signs of disease. This is used to find Kaposi sarcoma lesions in the gastrointestinal tract.      - Bronchoscopy for biopsy: A procedure to look inside the trachea and large airways in the lung for abnormal areas. A bronchoscope is inserted through the nose or mouth into the trachea and lungs. A bronchoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a tool to remove tissue samples, which are checked under a microscope for signs of disease. This is used to find Kaposi sarcoma lesions in the lungs.
                
                
                    After Kaposi sarcoma has been diagnosed, tests are done to find out if cancer cells have spread to other parts of the body.
                    The following tests and procedures may be used to find out if cancer has spread to other parts of the body:         -   Blood chemistry studies : A procedure in which a blood sample is checked to measure the amounts of certain substances released into the blood by organs and tissues in the body. An unusual (higher or lower than normal) amount of a substance can be a sign of disease.    -   CT scan (CAT scan): A procedure that makes a series of detailed pictures of areas inside the body, such as the lung, liver, and spleen, taken from different angles. The pictures are made by a computer linked to an x-ray machine. A dye may be injected into a vein or swallowed to help the organs or tissues show up more clearly. This procedure is also called computed tomography, computerized tomography, or computerized axial tomography.    -   PET scan (positron emission tomography scan): A procedure to find malignant tumor cells in the body. A small amount of radioactive glucose (sugar) is injected into a vein. The PET scanner rotates around the body and makes a picture of where glucose is being used in the body. Malignant tumor cells show up brighter in the picture because they are more active and take up more glucose than normal cells do. This imaging test checks for signs of cancer in the lung, liver, and spleen.    -   CD34 lymphocyte count: A procedure in which a blood sample is checked to measure the amount of CD34 cells (a type of white blood cell). A lower than normal amount of CD34 cells can be a sign the immune system is not working well.
                
                
                    Certain factors affect prognosis (chance of recovery) and treatment options.
                    The prognosis (chance of recovery) and treatment options depend on the following:          - The type of Kaposi sarcoma.    - The general health of the patient, especially the patient's immune system.    - Whether the cancer has just been diagnosed or has recurred (come back).
                                
                
				               Classic Kaposi Sarcoma
							            
							                
							                    Key Points
							                    - Classic Kaposi sarcoma is found most often in older men of Italian or Eastern European Jewish origin.    - Signs of classic Kaposi sarcoma may include slow-growing lesions on the legs and feet.    - Another cancer may develop.
							                
							                
							                    Classic Kaposi sarcoma is found most often in older men of Italian or Eastern European Jewish origin.
							                    Classic Kaposi sarcoma is a rare disease that gets worse slowly over many years.
							                
							                
							                    Signs of classic Kaposi sarcoma may include slow-growing lesions on the legs and feet.
							                    Patients may have one or more red, purple, or brown skin lesions on the legs and feet, most often on the ankles or soles of the feet. Over time, lesions may form in other parts of the body, such as the stomach, intestines, or lymph nodes. The lesions usually don't cause any symptoms, but may grow in size and number over a period of 10 years or more. Pressure from the lesions may block the flow of lymph and blood in the legs and cause painful swelling. Lesions in the digestive tract may cause gastrointestinal bleeding.
							                
							                
							                    Another cancer may develop.
							                    Some patients with classic Kaposi sarcoma may develop another type of cancer before the Kaposi sarcoma lesions appear or later in life. Most often, this second cancer is non-Hodgkin lymphoma. Frequent follow-up is needed to watch for these second cancers.
							                
							            
							         
							        
							            Epidemic Kaposi Sarcoma
							            
							                
							                    Key Points
							                    - Epidemic Kaposi sarcoma is found in patients who have acquired immunodeficiency syndrome (AIDS).    - Signs of epidemic Kaposi sarcoma can include lesions that form in many parts of the body.    - The use of drug therapy called cART reduces the risk of epidemic Kaposi sarcoma in patients infected with HIV.
							                
							                
							                    Epidemic Kaposi sarcoma is found in patients who have acquired immunodeficiency syndrome (AIDS).
							                    Epidemic Kaposi sarcoma occurs in patients who have acquired immunodeficiency syndrome (AIDS). AIDS is caused by the human immunodeficiency virus (HIV), which attacks and weakens the immune system. When the body's immune system is weakened by HIV, infections and cancers such as Kaposi sarcoma can develop.   Most cases of epidemic Kaposi sarcoma in the United States have been diagnosed in homosexual or bisexual men infected with HIV.
							                
							                
							                    Signs of epidemic Kaposi sarcoma can include lesions that form in many parts of the body.
							                    The signs of epidemic Kaposi sarcoma can include lesions in different parts of the body, including any of the following:          - Skin.    - Lining of the mouth.    -  Lymph nodes.    -  Stomach and intestines.    -  Lungs and lining of the chest.    -  Liver.    -  Spleen.        Kaposi sarcoma is sometimes found in the lining of the mouth during a regular dental check-up.    In most patients with epidemic Kaposi sarcoma, the disease will spread to other parts of the body over time. Fever, weight loss, or diarrhea can occur. In the later stages of epidemic Kaposi sarcoma, life-threatening infections are common.
							                
							                
							                    The use of drug therapy called cART reduces the risk of epidemic Kaposi sarcoma in patients infected with HIV.
							                    Combined antiretroviral therapy (cART) is a combination of several drugs that block HIV and slow down the development of AIDS and AIDS-related Kaposi sarcoma. For information about AIDS and its treatment, see the AIDSinfo website.
							                
							            
							                
                
                    Tests that examine the skin, lungs, and gastrointestinal tract are used to detect (find) and diagnose Kaposi sarcoma.
                    The following tests and procedures may be used:         -   Physical exam and history : An exam of the body to check general signs of health, including checking skin and lymph nodes for signs of disease, such as lumps or anything else that seems unusual. A history of the patient's health habits and past illnesses and treatments will also be taken.    -   Chest x-ray : An x-ray of the organs and bones inside the chest. An x-ray is a type of energy beam that can go through the body and onto film, making a picture of areas inside the body. This is used to find Kaposi sarcoma in the lungs.    -   Biopsy : The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer.  One of the following types of biopsies may be done to check for Kaposi sarcoma lesions in the skin:               -  Excisional biopsy : A scalpel is used to remove the entire skin growth.       -  Incisional biopsy : A scalpel is used to remove part of a skin growth.      -  Core biopsy : A wide needle is used to remove part of a skin growth.      -  Fine-needle aspiration (FNA) biopsy : A thin needle is used to remove part of a skin growth.          An endoscopy or bronchoscopy may be done to check for Kaposi sarcoma lesions in the gastrointestinal tract or lungs.               - Endoscopy for biopsy: A procedure to look at organs and tissues inside the body to check for abnormal areas. An endoscope is inserted through an incision (cut) in the skin or opening in the body, such as the mouth. An endoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a tool to remove tissue or lymph node samples, which are checked under a microscope for signs of disease. This is used to find Kaposi sarcoma lesions in the gastrointestinal tract.      - Bronchoscopy for biopsy: A procedure to look inside the trachea and large airways in the lung for abnormal areas. A bronchoscope is inserted through the nose or mouth into the trachea and lungs. A bronchoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a tool to remove tissue samples, which are checked under a microscope for signs of disease. This is used to find Kaposi sarcoma lesions in the lungs.
                
                
                    After Kaposi sarcoma has been diagnosed, tests are done to find out if cancer cells have spread to other parts of the body.
                    The following tests and procedures may be used to find out if cancer has spread to other parts of the body:         -   Blood chemistry studies : A procedure in which a blood sample is checked to measure the amounts of certain substances released into the blood by organs and tissues in the body. An unusual (higher or lower than normal) amount of a substance can be a sign of disease.    -   CT scan (CAT scan): A procedure that makes a series of detailed pictures of areas inside the body, such as the lung, liver, and spleen, taken from different angles. The pictures are made by a computer linked to an x-ray machine. A dye may be injected into a vein or swallowed to help the organs or tissues show up more clearly. This procedure is also called computed tomography, computerized tomography, or computerized axial tomography.    -   PET scan (positron emission tomography scan): A procedure to find malignant tumor cells in the body. A small amount of radioactive glucose (sugar) is injected into a vein. The PET scanner rotates around the body and makes a picture of where glucose is being used in the body. Malignant tumor cells show up brighter in the picture because they are more active and take up more glucose than normal cells do. This imaging test checks for signs of cancer in the lung, liver, and spleen.    -   CD34 lymphocyte count: A procedure in which a blood sample is checked to measure the amount of CD34 cells (a type of white blood cell). A lower than normal amount of CD34 cells can be a sign the immune system is not working well.
                
                
                    Certain factors affect prognosis (chance of recovery) and treatment options.
                    The prognosis (chance of recovery) and treatment options depend on the following:          - The type of Kaposi sarcoma.    - The general health of the patient, especially the patient's immune system.    - Whether the cancer has just been diagnosed or has recurred (come back).
(Source: CancerGov)