falan42/medcuad_data huggingface dataset:
Topic: Immune Thrombocytopenia
Question: What are the symptoms of Immune Thrombocytopenia ?
Answer: Immune thrombocytopenia (ITP) may not cause any signs or symptoms. However, ITP can cause bleeding inside the body (internal bleeding) or underneath or from the skin (external bleeding). Signs of bleeding may include:
                
Bruising or purplish areas on the skin or mucous membranes (such as in the mouth). These bruises are called purpura. They're caused by bleeding under the skin, and they may occur for no known reason.
                
Pinpoint red spots on the skin called petechiae. These spots often are found in groups and may look like a rash. Bleeding under the skin causes petechiae.
                
A collection of clotted or partially clotted blood under the skin that looks or feels like a lump. This is called a hematoma.
                
Nosebleeds or bleeding from the gums (for example, during dental work).
                
Blood in the urine or stool (bowel movement).
                
Any kind of bleeding that's hard to stop could be a sign of ITP. This includes menstrual bleeding that's heavier than normal. Bleeding in the brain is rare, and its symptoms may vary.
                
A low platelet count doesn't directly cause pain, problems concentrating, or other symptoms. However, a low platelet count might be associated with fatigue (tiredness).
(Source: NHLBI)
Topic: Immune Thrombocytopenia
Question: How to diagnose Immune Thrombocytopenia ?
Answer: Your doctor will diagnose immune thrombocytopenia (ITP) based on your medical history, a physical exam, and test results.
                
Your doctor will want to make sure that your low platelet count isn't due to another condition (such as an infection) or medicines you're taking (such as chemotherapy medicines or aspirin).
                
Medical History
                
Your doctor may ask about:
                
Your signs and symptoms of bleeding and any other signs or symptoms you're having
                
Whether you have illnesses that could lower your platelet count or cause bleeding
                
Medicines or any over-the-counter supplements or remedies you take that could cause bleeding or lower your platelet count
                
Physical Exam
                
During a physical exam, your doctor will look for signs of bleeding and infection. For example, your doctor may look for purplish areas on the skin or mucous membranes and pinpoint red spots on the skin. These are signs of bleeding under the skin.
                
Diagnostic Tests
                
You'll likely have blood tests to check your platelet count. These tests usually include:
                
A complete blood count. This test checks the number of red blood cells, white blood cells, and platelets in your blood. In ITP, the red and white blood cell counts are normal, but the platelet count is low.
                
A blood smear. For this test, some of your blood is put on a slide. A microscope is used to look at your platelets and other blood cells.
                
You also may have a blood test to check for the antibodies (proteins) that attack platelets.
                
If blood tests show that your platelet count is low, your doctor may recommend more tests to confirm a diagnosis of ITP. For example, bone marrow tests can show whether your bone marrow is making enough platelets.
                
If you're at risk for HIV, hepatitis C, or H. pylori, your doctor may screen you for these infections, which might be linked to ITP.
                
Some people who have mild ITP have few or no signs of bleeding. They may be diagnosed only if a blood test done for another reason shows that they have low platelet counts.
(Source: NHLBI)
Topic: Immune Thrombocytopenia
Question: How to prevent Immune Thrombocytopenia ?
Answer: You can't prevent immune thrombocytopenia (ITP), but you can prevent its complications.
                
Talk with your doctor about which medicines are safe for you. Your doctor may advise you to avoid medicines that can affect your platelets and increase your risk of bleeding. Examples of such medicines include aspirin and ibuprofen.
                
Protect yourself from injuries that can cause bruising or bleeding.
                
Seek treatment right away if you develop any infections. Report any symptoms of infection, such as a fever, to your doctor. This is very important for people who have ITP and have had their spleens removed.
(Source: NHLBI)
Topic: Pernicious Anemia
Question: What is (are) Pernicious Anemia ?
Answer: Pernicious anemia (per-NISH-us uh-NEE-me-uh) is a condition in which the body can't make enough healthy red blood cells because it doesn't have enough vitamin B12.
                
Vitamin B12 is a nutrient found in some foods. The body needs this nutrient to make healthy red blood cells and to keep its nervous system working properly.
                
People who have pernicious anemia can't absorb enough vitamin B12 from food. This is because they lack intrinsic (in-TRIN-sik) factor, a protein made in the stomach. A lack of this protein leads to vitamin B12 deficiency.
                
Other conditions and factors also can cause vitamin B12 deficiency. Examples include infections, surgery, medicines, and diet. Technically, the term "pernicious anemia" refers to vitamin B12 deficiency due to a lack of intrinsic factor. Often though, vitamin B12 deficiency due to other causes also is called pernicious anemia.
                
This article discusses pernicious anemia due to a lack of intrinsic factor and other causes.
                
Overview
                
Pernicious anemia is a type of anemia. The term "anemia" usually refers to a condition in which the blood has a lower than normal number of red blood cells. In pernicious anemia, the body can't make enough healthy red blood cells because it doesn't have enough vitamin B12.
                
Without enough vitamin B12, your red blood cells don't divide normally and are too large. They may have trouble getting out of the bone marrowa sponge-like tissue inside the bones where blood cells are made.
                
Without enough red blood cells to carry oxygen to your body, you may feel tired and weak. Severe or long-lasting pernicious anemia can damage the heart, brain, and other organs in the body.
                
Pernicious anemia also can cause other problems, such as nerve damage, neurological problems (such as memory loss), and digestive tract problems. People who have pernicious anemia also may be at higher risk for weakened bone strength and stomach cancer.
                
Outlook
                
The term pernicious means deadly. The condition is called pernicious anemia because it often was fatal in the past, before vitamin B12 treatments were available. Now, pernicious anemia usually is easy to treat with vitamin B12 pills or shots.
                
With ongoing care and proper treatment, most people who have pernicious anemia can recover, feel well, and live normal lives.
                
Without treatment, pernicious anemia can lead to serious problems with the heart, nerves, and other parts of the body. Some of these problems may be permanent.
(Source: NHLBI)
Topic: Pernicious Anemia
Question: Who is at risk for Pernicious Anemia? ?
Answer: Pernicious anemia is more common in people of Northern European and African descent than in other ethnic groups.
                
Older people also are at higher risk for the condition. This is mainly due to a lack of stomach acid and intrinsic factor, which prevents the small intestine from absorbing vitamin B12. As people grow older, they tend to make less stomach acid.
                
Pernicious anemia also can occur in younger people and other populations. You're at higher risk for pernicious anemia if you:
                
Have a family history of the condition.
                
Have had part or all of your stomach surgically removed. The stomach makes intrinsic factor. This protein helps your body absorb vitamin B12.
                
Have an autoimmune disorder that involves the endocrine glands, such as Addison's disease, type 1 diabetes, Graves' disease, or vitiligo. Research suggests a link may exist between these autoimmune disorders and pernicious anemia that's caused by an autoimmune response.
                
Have had part or all of your small intestine surgically removed. The small intestine is where vitamin B12 is absorbed.
                
Have certain intestinal diseases or other disorders that may prevent your body from properly absorbing vitamin B12. Examples include Crohn's disease, intestinal infections, and HIV.
                
Take medicines that prevent your body from properly absorbing vitamin B12. Examples of such medicines include antibiotics and certain seizure medicines.
                
Are a strict vegetarian who doesn't eat any animal or dairy products and doesn't take a vitamin B12 supplement, or if you eat poorly overall.
(Source: NHLBI)
Topic: Pernicious Anemia
Question: What are the symptoms of Pernicious Anemia ?
Answer: A lack of vitamin B12 (vitamin B12 deficiency) causes the signs and symptoms of pernicious anemia. Without enough vitamin B12, your body can't make enough healthy red blood cells, which causes anemia.
                
Some of the signs and symptoms of pernicious anemia apply to all types of anemia. Other signs and symptoms are specific to a lack of vitamin B12.
                
Signs and Symptoms of Anemia
                
The most common symptom of all types of anemia is fatigue (tiredness). Fatigue occurs because your body doesnt have enough red blood cells to carry oxygen to its various parts.
                
A low red blood cell count also can cause shortness of breath, dizziness, headache, coldness in your hands and feet, pale or yellowish skin, and chest pain.
                
A lack of red blood cells also means that your heart has to work harder to move oxygen-rich blood through your body. This can lead to irregular heartbeats called arrhythmias (ah-RITH-me-ahs), heart murmur, an enlarged heart, or even heart failure.
                
Signs and Symptoms of Vitamin B12 Deficiency
                
Vitamin B12 deficiency may lead to nerve damage. This can cause tingling and numbness in your hands and feet, muscle weakness, and loss of reflexes. You also may feel unsteady, lose your balance, and have trouble walking. Vitamin B12 deficiency can cause weakened bones and may lead to hip fractures.
                
Severe vitamin B12 deficiency can cause neurological problems, such as confusion, dementia, depression, and memory loss.
                
Other symptoms of vitamin B12 deficiency involve the digestive tract. These symptoms include nausea (feeling sick to your stomach) and vomiting, heartburn, abdominal bloating and gas, constipation or diarrhea, loss of appetite, and weight loss. An enlarged liver is another symptom.
                
A smooth, thick, red tongue also is a sign of vitamin B12 deficiency and pernicious anemia.
                
Infants who have vitamin B12 deficiency may have poor reflexes or unusual movements, such as face tremors. They may have trouble feeding due to tongue and throat problems. They also may be irritable. If vitamin B12 deficiency isn't treated, these infants may have permanent growth problems.
(Source: NHLBI)
Topic: Pernicious Anemia
Question: What are the treatments for Pernicious Anemia ?
Answer: Doctors treat pernicious anemia by replacing the missing vitamin B12 in the body. People who have pernicious anemia may need lifelong treatment.
                
The goals of treating pernicious anemia include:
                
Preventing or treating the anemia and its signs and symptoms
                
Preventing or managing complications, such as heart and nerve damage
                
Treating the cause of the pernicious anemia (if a cause can be found)
                
Specific Types of Treatment
                
Pernicious anemia usually is easy to treat with vitamin B12 shots or pills.
                
If you have severe pernicious anemia, your doctor may recommend shots first. Shots usually are given in a muscle every day or every week until the level of vitamin B12 in your blood increases. After your vitamin B12 blood level returns to normal, you may get a shot only once a month.
                
For less severe pernicious anemia, your doctor may recommend large doses of vitamin B12 pills. A vitamin B12 nose gel and spray also are available. These products may be useful for people who have trouble swallowing pills, such as older people who have had strokes.
                
Your signs and symptoms may begin to improve within a few days after you start treatment. Your doctor may advise you to limit your physical activity until your condition improves.
                
If your pernicious anemia is caused by something other than a lack of intrinsic factor, you may get treatment for the cause (if a cause can be found). For example, your doctor may prescribe medicines to treat a condition that prevents your body from absorbing vitamin B12.
                
If medicines are the cause of your pernicious anemia, your doctor may change the type or dose of medicine you take. Infants of strict vegetarian mothers may be given vitamin B12 supplements from birth.
(Source: NHLBI)
Topic: Pernicious Anemia
Question: How to prevent Pernicious Anemia ?
Answer: You can't prevent pernicious anemia caused by a lack of intrinsic factor. Without intrinsic factor, you won't be able to absorb vitamin B12 and will develop pernicious anemia.
                
Although uncommon, some people develop pernicious anemia because they don't get enough vitamin B12 in their diets. You can take steps to prevent pernicious anemia caused by dietary factors.
                
Eating foods high in vitamin B12 can help prevent low vitamin B12 levels. Good food sources of vitamin B12 include:
                
Breakfast cereals with added vitamin B12
                
Meats such as beef, liver, poultry, and fish
                
Eggs and dairy products (such as milk, yogurt, and cheese)
                
Foods fortified with vitamin B12, such as soy-based beverages and vegetarian burgers
                
If youre a strict vegetarian, talk with your doctor about having your vitamin B12 level checked regularly.
                
Vitamin B12 also is found in multivitamins and B-complex vitamin supplements. Doctors may recommend supplements for people at risk for vitamin B12 deficiency, such as strict vegetarians or people who have had stomach surgery.
                
Older adults may have trouble absorbing vitamin B12. Thus, doctors may recommend that older adults eat foods fortified with vitamin B12 or take vitamin B12 supplements.
(Source: NHLBI)
Topic: Deep Vein Thrombosis
Question: What is (are) Deep Vein Thrombosis ?
Answer: Espaol
                
Deep vein thrombosis (throm-BO-sis), or DVT, is a blood clot that forms in a vein deep in the body. Blood clots occur when blood thickens and clumps together.
                
Most deep vein blood clots occur in the lower leg or thigh. They also can occur in other parts of the body.
                
A blood clot in a deep vein can break off and travel through the bloodstream. The loose clot is called an embolus (EM-bo-lus). It can travel to an artery in the lungs and block blood flow. This condition is called pulmonary embolism (PULL-mun-ary EM-bo-lizm), or PE.
                
PE is a very serious condition. It can damage the lungs and other organs in the body and cause death.
                
Blood clots in the thighs are more likely to break off and cause PE than blood clots in the lower legs or other parts of the body. Blood clots also can form in veins closer to the skin's surface. However, these clots won't break off and cause PE.
                
The animation below shows a deep vein blood clot. Click the "start" button to play the animation. Written and spoken explanations are provided with each frame. Use the buttons in the lower right corner to pause, restart, or replay the animation, or use the scroll bar below the buttons to move through the frames.
                

                

                
The animation shows how a blood clot in a deep vein of the leg can break off, travel to the lungs, and block blood flow.
(Source: NHLBI)
Topic: Deep Vein Thrombosis
Question: What causes Deep Vein Thrombosis ?
Answer: Blood clots can form in your body's deep veins if:
                
A vein's inner lining is damaged. Injuries caused by physical, chemical, or biological factors can damage the veins. Such factors include surgery, serious injuries, inflammation, and immune responses.
                
Blood flow is sluggish or slow. Lack of motion can cause sluggish or slow blood flow. This may occur after surgery, if you're ill and in bed for a long time, or if you're traveling for a long time.
                
Your blood is thicker or more likely to clot than normal. Some inherited conditions (such as factor V Leiden) increase the risk of blood clotting. Hormone therapy or birth control pills also can increase the risk of clotting.
(Source: NHLBI)
Topic: Deep Vein Thrombosis
Question: Who is at risk for Deep Vein Thrombosis? ?
Answer: The risk factors for deep vein thrombosis (DVT) include:
                
A history of DVT.
                
Conditions or factors that make your blood thicker or more likely to clot than normal. Some inherited blood disorders (such as factor V Leiden) will do this. Hormone therapy or birth control pills also increase the risk of clotting.
                
Injury to a deep vein from surgery, a broken bone, or other trauma.
                
Slow blood flow in a deep vein due to lack of movement. This may occur after surgery, if you're ill and in bed for a long time, or if you're traveling for a long time.
                
Pregnancy and the first 6 weeks after giving birth.
                
Recent or ongoing treatment for cancer.
                
A central venous catheter. This is a tube placed in a vein to allow easy access to the bloodstream for medical treatment.
                
Older age. Being older than 60 is a risk factor for DVT, although DVT can occur at any age.
                
Overweight or obesity.
                
Smoking.
                
Your risk for DVT increases if you have more than one of the risk factors listed above.
(Source: NHLBI)
Topic: Deep Vein Thrombosis
Question: What are the symptoms of Deep Vein Thrombosis ?
Answer: The signs and symptoms of deep vein thrombosis (DVT) might be related to DVT itself or pulmonary embolism (PE). See your doctor right away if you have signs or symptoms of either condition. Both DVT and PE can cause serious, possibly life-threatening problems if not treated.
                
Deep Vein Thrombosis
                
Only about half of the people who have DVT have signs and symptoms. These signs and symptoms occur in the leg affected by the deep vein clot. They include:
                
Swelling of the leg or along a vein in the leg
                
Pain or tenderness in the leg, which you may feel only when standing or walking
                
Increased warmth in the area of the leg that's swollen or painful
                
Red or discolored skin on the leg
                
Pulmonary Embolism
                
Some people aren't aware of a deep vein clot until they have signs and symptoms of PE. Signs and symptoms of PE include:
                
Unexplained shortness of breath
                
Pain with deep breathing
                
Coughing up blood
                
Rapid breathing and a fast heart rate also may be signs of PE.
(Source: NHLBI)
Topic: Deep Vein Thrombosis
Question: How to diagnose Deep Vein Thrombosis ?
Answer: Your doctor will diagnose deep vein thrombosis (DVT) based on your medical history, a physical exam, and test results. He or she will identify your risk factors and rule out other causes of your symptoms.
                
For some people, DVT might not be diagnosed until after they receive emergency treatment for pulmonary embolism (PE).
                
Medical History
                
To learn about your medical history, your doctor may ask about:
                
Your overall health
                
Any prescription medicines you're taking
                
Any recent surgeries or injuries you've had
                
Whether you've been treated for cancer
                
Physical Exam
                
Your doctor will check your legs for signs of DVT, such as swelling or redness. He or she also will check your blood pressure and your heart and lungs.
                
Diagnostic Tests
                
Your doctor may recommend tests to find out whether you have DVT.
                
Common Tests
                
The most common test for diagnosing deep vein blood clots is ultrasound. This test uses sound waves to create pictures of blood flowing through the arteries and veins in the affected leg.
                
Your doctor also may recommend a D-dimer test or venography (ve-NOG-rah-fee).
                
A D-dimer test measures a substance in the blood that's released when a blood clot dissolves. If the test shows high levels of the substance, you may have a deep vein blood clot. If your test results are normal and you have few risk factors, DVT isn't likely.
                
Your doctor may suggest venography if an ultrasound doesn't provide a clear diagnosis. For venography, dye is injected into a vein in the affected leg. The dye makes the vein visible on an x-ray image. The x ray will show whether blood flow is slow in the vein, which may suggest a blood clot.
                
Other Tests
                
Other tests used to diagnose DVT include magnetic resonance imaging (MRI) and computed tomography (to-MOG-rah-fee), or CT, scanning. These tests create pictures of your organs and tissues.
                
You may need blood tests to check whether you have an inherited blood clotting disorder that can cause DVT. This may be the case if you have repeated blood clots that are not related to another cause. Blood clots in an unusual location (such as the liver, kidney, or brain) also may suggest an inherited clotting disorder.
                
If your doctor thinks that you have PE, he or she may recommend more tests, such as a lung ventilation perfusion scan (VQ scan). A lung VQ scan shows how well oxygen and blood are flowing to all areas of the lungs.
                
For more information about diagnosing PE, go to the Health Topics Pulmonary Embolism article.
(Source: NHLBI)