Topic: Mycosis Fungoides and the Szary Syndrome
Question: What are the stages of Mycosis Fungoides and the Szary Syndrome ?
Answer: Key Points
                    - After mycosis fungoides and the Szary syndrome have been diagnosed, tests are done to find out if cancer cells have spread from the skin to other parts of the body.     - There are three ways that cancer spreads in the body.    - Cancer may spread from where it began to other parts of the body.    - The following stages are used for mycosis fungoides and the Szary syndrome:         - Stage I Mycosis Fungoides     - Stage II Mycosis Fungoides     - Stage III Mycosis Fungoides     - Stage IV Mycosis Fungoides     - Stage IV Szary Syndrome
                
                
                    After mycosis fungoides and the Szary syndrome have been diagnosed, tests are done to find out if cancer cells have spread from the skin to other parts of the body.
                    The process used to find out if cancer has spread from the skin to other parts of the body is called staging. The information gathered from the staging process determines the stage of the disease. It is important to know the stage in order to plan treatment.    The following procedures may be used in the staging process:         -   Chest x-ray : An x-ray of the organs and bones inside the chest. An x-ray is a type of energy beam that can go through the body and onto film, making a picture of areas inside the body.    -   CT scan (CAT scan): A procedure that makes a series of detailed pictures of areas inside the body, such as the lymph nodes, chest, abdomen, and pelvis, taken from different angles. The pictures are made by a computer linked to an x-ray machine. A dye may be injected into a vein or swallowed to help the organs or tissues show up more clearly. This procedure is also called computed tomography, computerized tomography, or computerized axial tomography.     -   PET scan (positron emission tomography scan): A procedure to find malignant tumor cells in the body. A small amount of radioactive glucose (sugar) is injected into a vein. The PET scanner rotates around the body and makes a picture of where glucose is being used in the body. Malignant tumor cells show up brighter in the picture because they are more active and take up more glucose than normal cells do.    -  Lymph node biopsy : The removal of all or part of a lymph node. A pathologist views the tissue under a microscope to look for cancer cells.    -   Bone marrow aspiration and biopsy : The removal of bone marrow and a small piece of bone by inserting a hollow needle into the hipbone or breastbone. A pathologist views the bone marrow and bone under a microscope to look for signs of cancer.
                
                
                    There are three ways that cancer spreads in the body.
                    Cancer can spread through tissue, the lymph system, and the blood:         - Tissue. The cancer spreads from where it began by growing into nearby areas.     - Lymph system. The cancer spreads from where it began by getting into the lymph system. The cancer travels through the lymph vessels to other parts of the body.     - Blood. The cancer spreads from where it began by getting into the blood. The cancer travels through the blood vessels to other parts of the body.
                
                
                    Cancer may spread from where it began to other parts of the body.
                    When cancer spreads to another part of the body, it is called metastasis. Cancer cells break away from where they began (the primary tumor) and travel through the lymph system or blood.         - Lymph system. The cancer gets into the lymph system, travels through the lymph vessels, and forms a tumor (metastatic tumor) in another part of the body.    - Blood. The cancer gets into the blood, travels through the blood vessels, and forms a tumor (metastatic tumor) in another part of the body.        The metastatic tumor is the same type of cancer as the primary tumor. For example, if mycosis fungoides spreads to the liver, the cancer cells in the liver are actually mycosis fungoides cells. The disease is metastatic mycosis fungoides, not liver cancer.
                
                
                    The following stages are used for mycosis fungoides and the Szary syndrome:
                    Stage I Mycosis Fungoides     Stage I is divided into stage IA and stage IB as follows:            -  Stage IA: Less than 10% of the skin surface is covered with patches, papules, and/or plaques.      -  Stage IB: Ten percent or more of the skin surface is covered with patches, papules, and/or plaques.           There may be abnormal lymphocytes in the blood but they are not cancerous.       Stage II Mycosis Fungoides     Stage II is divided into stage IIA and stage IIB as follows:            -  Stage IIA: Any amount of the skin surface is covered with patches, papules, and/or plaques. Lymph nodes are enlarged but cancer has not spread to them.     -  Stage IIB: One or more tumors that are 1 centimeter or larger are found on the skin. Lymph nodes may be enlarged but cancer has not spread to them.           There may be abnormal lymphocytes in the blood but they are not cancerous.       Stage III Mycosis Fungoides    In stage III, nearly all of the skin is reddened and may have patches, papules, plaques, or tumors. Lymph nodes may be enlarged but cancer has not spread to them.    There may be abnormal lymphocytes in the blood but they are not cancerous.       Stage IV Mycosis Fungoides     Stage IV is divided into stage IVA and stage IVB as follows:            -  Stage IVA: Most of the skin is reddened and any amount of the skin surface is covered with patches, papules, plaques, or tumors, and either:                   -  cancer has spread to lymph nodes and there may be cancerous lymphocytes in the blood; or       - there are cancerous lymphocytes in the blood and lymph nodes may be enlarged, but cancer has not spread to them.                 -  Stage IVB: Most of the skin is reddened and any amount of the skin surface is covered with patches, papules, plaques, or tumors. Cancer has spread to other organs in the body. Lymph nodes may be enlarged and cancer may have spread to them. There may be cancerous lymphocytes in the blood.              Stage IV Szary Syndrome    In stage IV:            - Most of the skin is reddened and covered with patches, papules, plaques, or tumors; and     - There is a high level of cancerous lymphocytes in the blood; and     -  Lymph nodes may be enlarged and cancer may have spread to them.
(Source: CancerGov)