fairdataihub/poster-sentry-training-data huggingface dataset:
Services Home  / Services / Data Analysis / Fusion Analysis Fusion Analysis Introduction of Fusion Analysis Gene fusion refers to the fusion of some or all of the sequences of two different genes due to some mechanism (such as genome mutation) to form a new gene. Gene fusion includes fusion at the genome level and fusion at the transcriptome level. At the DNA level, a new gene composed of two or more genes is called a fusion gene. At the RNA level, a transcript composed of multiple transcripts is called a fusion transcript. In a broad sense, these two are called fusion genes. There are three main mechanisms for gene fusion: chromosomal translocation, interstitial deletion and chromosomal inversion. As a product of chromosome structural variation, fusion genes have been proved to be related to the occurrence of certain cancers, and they are the key targets for research on certain cancers. Fusion genes are caused by chromosomal mutations, and fusion genes are often oncogenes. When genes that regulate Privacy - Terms  HOME  SERVICES  SOLUTIONS  PLATFORM CAREERS CONTACT US 
Influence of composition shift and reaction pathway on kesterite device properties and long-term stability David Nowak*, Anu Paudel, Timo Pfeiffelmann, Devendra Pareek, Levent Gütay *E-Mail: david.nowak@uni- oldenburg.de University of Oldenburg, Institute of Physics, Ultrafast nanoscale dynamics (UND) group, 26111 Oldenburg, Germany This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement no. 952982 (“Custom-Art”) Precursor / Absorber composition Precursor compositions varied by: Different sputtering durations for elemental Sn During Annealing process: Re-alloying + Reaction with Se + SnSe2 (incorporation / loss of Sn) similar absorber composition at the end Variation of process parameters allows for independent tuning of starting and ending composition Introduction • Efficiencies of kesterites have been stagnant • Challenges and possible opportunities: • Influence of reaction pathway on defect landscape not well understood yet • Influence of defect landscape on per- formance and stability not fully explored Motivation: Independent tuning of the starting and end compositions can be a helpful approach towards such investigation Conclusions The Cu/Sn and Cu3Sn/Cu6Sn5 ratio, respectively, influences the composition shift and reaction pathway. Precursors with high Cu6Sn5 content result in high efficiencies. The pathway also influences the stability of devices. Experimental • Stacked elemental-alloyed precursors • Different Cu/Sn ratios Mo / Zn / Cu-Sn / (Sn) / Zn • Annealing in identical conditions • Composition+phase tracked (XRD & Raman) Resulting device efficiencies Details on reaction pathways and composition shift: [1] D. Pareek et al., Sol. RRL 2020, 4, 2000124 [2] D. Nowak et al., Sol. RRL 2021, 5, 2100237 1/3
Accelerated Education, Research Poster Negative impacts Based on a case study applied to teachers and students from various educational institutions, it was identiﬁed that intuitive cognition is the basis for the educational practices adopted in the Valley of Mexico region. Material Two types of instruments were applied from the ISTE and CASEL standards on the Google forms and Jotfoms platforms. Hypothesis In everyday experiences, the recognition of a segment of reality is correlated with what you want to know, you only need a good reason to intuitively choose a prediction. Objectives ● Establish segments of educational populations that identify intuitive cognition in their self-study. ● Identify educational populations that do not appropriate learning from intuitive cognition. Research Conclusion Methodology Analysis Academics who make their learning practice aware from intuitive cognition were segmented The testimonies of teachers at various educational levels are collected. Results The management of soft skills depends on the contexts of the teachers surveyed, in general they lack training that involves the management of an intuitive cognition located in the technological tools It is concluded that the skills called weak are associated with intuitive cognition to a greater extent than learning of rational and experimental origin, which are still diﬃcult to access in the region. Discussion Latin American education, in an attempt to adapt to the economic demands of the globalized social system, proposes to accept the international standards of socio-emotional competencies in the regulated educational practice, which, due to the lack of a clear methodology and according to the national educational context, turns out to be messy, the CASEL standards adhere to education plans as one more requirement to be fulﬁlled within it, without prioritizing the development of said skills from an early age. This is implicitly reﬂected in the evaluation carried out, due to the subjectivity with which the instrument was answered. The Leiden scale does not allow an objective measurement but relativizes the calculation of the results; Therefore, it is suggested to use a Likert scale in future research. ORCID https://orcid.org/0000-0003-1074-1569 https://orcid.org/0000-0003-1074-1569 https://orcid.org/0000-0002-9711-0825 https://orcid.org/0000-0002-0257-2198 Doi: HOERIC Condensed abstract/abstract Data collection is random and does not represent a deﬁnitive trend. ISTE CASE Others 11 M 14 M 25 M 17 F 38 F 12 F 15 S/E 24 S/E 13 S/E Users who claimed to apply socio-affective standards in their professional practice
Development and Validation of a Transcriptomic Biomarker of Chemical-Induced Histone Deacetylase Inhibition in TK6 Cells Eunnara Cho1, 2, Andrea Rowan-Carroll1, Andrew Williams1, J. Christopher Corton3, Heng Hong Li4, 5, Albert Fornace Jr.4, 5, Cheryl Hobbs6, Carole L. Yauk1, 7 1Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada, 2Department of Biology, Carleton University, Ottawa, ON, Canada, 3 Center for Computational Toxicology and Exposure, US-EPA, Research Triangle Park, NC, USA, 4 Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C., USA, 5Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, D.C., USA, 6Integrated Laboratory Systems Inc., Research Triangle Park, NC, USA, 7 Department of Biology, University of Ottawa, Ottawa, ON, Canada INTRODUCTION  Global gene expression profiling provides insights into the mode of action (MOA) of a toxicant and can also be used to identify transcriptomic biomarkers  A transcriptomic biomarker is a group of genes that produces an expression pattern that is predictive of toxicants operating through a specific MOA  Such biomarkers enable rapid analyses of gene expression profiles to identify MOA-specific patterns of induction following chemical exposures  Histone deacetylase (HDAC) inhibition leads to hyper- acetylation and consequently, aberrant gene transcription  Gene expression perturbation by HDAC inhibitors (HDACi) and other epigenotoxicants has been associated with developmental and neurological toxicities, and different types of cancers OBJECTIVES To develop a transcriptomic biomarker of HDACi for applications in chemical screening and assess the classification ability of the biomarker MATERIALS AND METHODS Concentration Optimization  The biomarker development approach described by Li et al. (2015) was adapted to develop a HDACi transcriptomic biomarker  A reference set of 20 compounds and a validation set of 11 compounds were selected  TK6 human lymphoblastoid cells were exposed to the reference and validation compounds for 4 hours  For each compound, one concentration was selected for whole transcriptome profiling by TempO-seq (template oligo detection sequencing) based on: a) >50% cell viability at 24 h measured by MTT assay b)Largest fold changes in three genes indicative of transcriptional responses to exposure at 4h, measured by qPCR  HDACi Indicator genes: RGL1, NEU1, GPR183  Non-HDACi Indicator genes1: ATF3, GADD45A, CDKN1A This project was funded by Health Canada’s Genomics Research and Development Initiative (GRDI) awarded to CLY
Final conference, Rome October 11, 2016 Water geochemistry of cryoconites in Eqip Sermia Glacier, Greenland: preliminary data Authorship: Laura Sanna1, Alessio Romeo2. 1Institute for Biometeorology, National Research Council of Italy, Sassari, Italy. E-mail: speleokikers@tiscali.it; 2La Venta Associazione Esplorazioni Geografiche, Treviso, Italy. Abstract Current climate warming is accelerating mass loss from most of the arctic glaciers. The Greenland Ice Sheet (GrIS) has also experienced dramatic ice melt in recent years (Koenig et al., 2016) with an increase in crevices that serve as conduits (called moulins) that transport meltwater rapidly into the glacier (Figure 1, down). Water, flowing through these moulins down to the bottom of the ice sheet and towards the sea, can modify the primary geochemical signature of precipitation. Moreover, a certain part of the glacial surface is dispersed by cryoconite holes, near-vertical tubes formed as consequence of melting induced by solar heating of dark debris (Cook et al., 2016) (Figure 1, up). Cryoconite hole may contribute to the glacial runoff on ablating ice surface (Fountain et al., 2008). Although a big effort has been done from the scientific community in order to interpret the sedimentary records of past extreme events in arctic areas, rather little is known about the geochemistry of glacial meltwater input into the oceans. For this reason, it is of interest to measure the concentration of elements accumulate in the unmelted ice body and on the meltwater within cryoconite holes flowing into the moulins. In this study the preliminary data about the major element compositions and the heavy metals level of ice and meltwater collected on Eqip Sermia Glacier (Greenland) are examined. Eqip Sermia Glacier is located close to Disko Bugt, in the central-western coast of Greenland, and represents the link between GrIS and its largest ice- free expanse proglacial area (Figure 2). During GRAAL II expedition (Greenland Research Animal and Algae) organized by Spélé'Ice Association in summer 2010 (Romeo et al, 2014), samples for geochemical analysis were collected in a region situated at 967 m asl, tens of kilometres from the glacial margin of the southern lobe (69°36 N - 49°47 W). Sampling took place within cryoconite holes (C4G) and inside the Fossil Moulin (C3G) at 15 m below the glacier surface (Figure 2). Figure 1: Cryoconite holes (up) and Fossil Moulin (down) in the Eqip Sermia Glacier (photos Alessio Romeo).
A framework for comparing worlds with and without climate change This framework can be used to compare an extreme event with and without climate change (Step 1), and then to determine if and how nature-based solutions can reduce or offset the impacts of climate change on the extreme event (Step 2 vs. Step 3). Step 2: In the world with climate change, simulate if and how the impacts of climate change on extreme events are made worse by the receiving environment (e.g., by local land and environmental conditions). World with climate change and without nature-based solutions Step 3: In the world with climate change, simulate if and how the impacts of climate change on extreme events are reduced when nature-based solutions are used. World with climate change and with nature-based solutions Step 1: Simulate an extreme event in a world with climate change and a world without climate change to quantify whether climate change made the extreme event more likely, more severe, or more long-lasting. From these simulations we can tell if: * the amount of water that can potentially be lost from the earth’s surface due to temperature, wind speed, humidity and cloud cover Read more: Holden, P.B., Rebelo, A.J., Wolski, P. et al. Nature-based solutions in mountain catchments reduce impact of anthropogenic climate change on drought streamflow. Commun Earth Environ 3, 51 (2022). https://doi.org/10.1038/s43247-022-00379-9 Read more: Holden, P.B., Rebelo, A.J., Wolski, P. et al. Nature-based solutions in mountain catchments reduce impact of anthropogenic climate change on drought streamflow. Commun Earth Environ 3, 51 (2022). https://doi.org/10.1038/s43247-022-00379-9 OR C0 levels at 405 parts per million 2 A world with climate change has: a thirstier atmosphere* more extreme rain events more intense storm surges longer heatwaves a less thirsty atmosphere* less extreme rain events less intense storm surges shorter heatwaves A world without climate change has: 2 C0 levels at 280 parts per million much less rain than expected an expected amount of rain Petra Holden and Mark New, 2024
Melusine of Cyprus: Studies in Art, Architecture, and Visual Culture in Honor of Annemarie Weyl Carr Friday 19 May 2017 09:00 Introduction Dr. Marina Solomidou-Ieronymidou, Director of the Department of Antiquities of Cyprus Dr. Andrew McCarthy, CAARI Director Paintings, Murals and Illumination 09:20 Charles Anthony Stewart (University of St. Thomas) Cyprus and the Development of Early Byzantine Fresco Painting 09:40 Maria G. Parani (University of Cyprus) On the Fringe: The Painted Ornament of the Holy Trinity Parekklesion at the Monastery of St. John Chrysostom, Koutsovendis 10:00 Andreas Nicolaïdès (Aix Marseille Université) Le cycle sanctoral de la Panagia Phorbiotissa à Asinou en 1105-1106 10:20 Athanasios Semoglou (Aristotle University of Thessaloniki) Sainte Thècle dans l'église de la Panagia Phorviotissa d'Asinou 10:40 Discussion 11:00 Coffee break 11:20 Rebecca W. Corrie (Bates College) Coppo, Chrysography, and Cyprus: “Networks and Interconnection” 11:40 Maria Paschali (Independent Scholar) The Late Medieval Wall Paintings of the Armenian Church in Famagusta and Cultural Identity in its Urban Setting
The UPWARDS project has received funding from the European Union's Horizon 2020 research and innovation programme under GA No. 763990. The information on this presentation reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein. Coordinator Stiftelsen SINTEF Prof. Jon Samseth Postboks 4760 Torgard 7465 Trondheim, Norway jon.samseth@sintef.no Phone: +47 98230641 www.upwards-wind.eu Understanding of the Physics of Wind Turbine and Rotor Dynamics through an Integrated Simulation Framework UPWARDS A Horizon 2020 project funded by the European Union UPWARDS project aims to make the development of bigger and better designed wind turbines possible, thus increasing the capacity of societies all over Europe and the rest of the world to harness wind-energy. UPWARDS gathers a consortium of 11 partners (companies, research institutes and universities) across 8 countries and 2 continents. UPWARDS is an European Commission (EC) backed project that promises to make achieving ambitious sustainability goals a reality.
Apoa1, a safe harbor locus for therapeutic liver genome editing Marco De Giorgi1, Ang Li2, Ayrea Hurley1, Mercedes Barzi3, Alexandria M. Doerfler1, Harrison E. Smith4, Charles Y. Lin4, Jonathan D. Brown5, Karl-Dimiter Bissig3, Gang Bao2, William R. Lagor1 1 Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA. 2 Department of Bioengineering, Rice University, Houston, TX, USA. 3 Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, NC, USA. 4 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. 5 Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. marco.degiorgi@bcm.edu
Colección de ESMOS 1 Maltasa, el remate del almidón Omar Betanzos Galicia* iD Licenciatura en Biotecnología, Facultad de Ciencias Biológicas, Benemérita Universidad Autónoma de Puebla, Puebla, México. *Email: omar.betanzosga@alumno.buap.mx 27 de Noviembre de 2022 DOI: http://doi.org/10.5281/zenodo.7367385 Editado por: Jesús Muñoz-Rojas (Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla). Revisado por: Laura Abisaí Pazos Rojas (Profesor Cátedra, Escuela de Bioingeniería y Ciencias, Tecnológico de Monterrey, Puebla, México. Facultad de Estomatología, Benemérita Universidad Autónoma de Puebla). Colección de ESMOS Resumen La maltasa, también conocida como α-glucosidasa, se encarga de la hidrólisis de la maltosa en las células del epitelio intestinal en el intestino delgado [1], durante los pasos finales de la digestión del almidón [2]. La existencia de maltasa fue demostrada en el año 1880 y actualmente se sabe que esta enzima no sólo se encuentra en mamíferos, sino que
Colección de ESMOS 1 Infografía ADN Helicasa Jorge Joani Gómez Arcos* iD Licenciatura en Biotecnología, Facultad de Ciencias Biológicas, Benemérita Universidad Autónoma de Puebla, Puebla, México. *Email: jojojogoar12@mail.com 02 de Febrero de 2023 DOI: http://doi.org/10.5281/zenodo.7597733 Editado por: Jesús Muñoz-Rojas (Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla). Revisado por: Norma Elena Rojas Ruíz (Responsable del Laboratorio de Microbiología 402, Edificio Multilaboratorios EMA-6, Benemérita Universidad Autónoma de Puebla, Puebla, México). Colección de ESMOS Resumen La obra que se adjunta tiene como objetivo resumir y/o explicar generalidades concernientes al tema “ADN Helicasa”, el trabajo pretende explicar a grosso modo características principales, historia, actividad enzimática e importancia de las enzimas “ADN Helicasas”. Esta infografía fue elaborada con el ánimo de difundir información de carácter científico, verdadera y clara con el fin de que el contenido pueda ser atendido por lectores no necesariamente pertenecientes al campo de estudio de las
EFCF 2023: Low-Temp. Fuel Cells, Electrolysers & H2 Processing 4 – 7 July 2023, Lucerne Switzerland A1713 / Page 1-8 A1713 Relation of Local Cell Voltage and Current Density Distribution during Fuel Starvation in PEMFC Stacks Jens Nissen (1,2), Jan Schwämmlein (1), Markus Hölzle (2) (1) cellcentric GmbH & Co. KG, Kirchheim unter Teck/Germany; (2) Zentrum für Sonnenenergie- und Wasserstoff-Forschung (ZSW), Ulm/Germany; Tel.: +49 17619162063 jens.nissen@cellcentic.net Abstract Gross fuel starvation is a harmful degradation stressor to polymer electrolyte membrane fuel cell (PEMFC) stacks. However, it is extremely difficult to fully avoid these events for integration level of fuel cell system and vehicle. In stack setups, properly reactant-supplied cells can apply their voltage to an undersupplied cell due to their electric serial connection. This can cause drastic local negative cell voltages, leading to substitutional reactions like the harmful carbon oxidation reaction. The presented study uses a 3-cell stack to illustrate how properly media supplied cells can apply their cell voltages to a starved cell. This stack consists of state-of-the-art automotive- sized membrane electrode assemblies and carbon composite bipolar plates. Fuel starvation of one cell was generated by an additional flow resistance in the hydrogen media inlet port. The local current density distribution of the starved cell showed two distinct regimes. These regimes suppose the occurrence of different electrochemical reactions along the flow direction. The progression of each fuel cells voltage along the flow field were measured by cell voltage monitoring measurements at eight positions. The voltage of the starved cell was found to be strongly inequal over the flow direction with intense negative voltages towards the fuel outlet. The occurrence of this non-equal cell voltages was explained by local measurements of the flow field plate potentials. A mechanism is proposed, which results in an increased carbon oxidation of the anode catalyst layer towards the fuel outlet during fuel starvation. This mechanism is unique to multi-cell fuel cells because it is based on the mutual distortion of cell voltages caused by electric interaction of adjacent fuel cells during gross fuel starvation.
Colección de ESMOS 1 Infografía El poder invisible de las micorrizas Zyanya Bravo Hernández iD, Melissa Escalante Avila iD, Roxana Montserrat Rodriguez Alfaro iD Maestría en ciencias (Microbiología), Centro de Investigaciones en Ciencias Microbiológicas, Benemérita Universidad Autónoma de Puebla, Puebla, México. *Email: ra223470261@alm.buap.mx 07 de mayo de 2024 DOI: http://doi.org/10.5281/zenodo.11124228 Editado por: Yolanda Elizabeth Morales-García (Facultad de Ciencias Biológicas, Benemérita Universidad Autónoma de Puebla, Puebla, México). Revisado por: Jesús Muñoz-Rojas (Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla, México). Apoyo en la maquetación: Luz del Carmen Cortés Reyes (Estudiante de Bioquímica Clínica, Universidad de las Américas Puebla, Puebla, México). Colección de ESMOS Resumen El ciclo del carbono es el resultado de una serie de procesos como lo son la fotosíntesis, respiración, el intercambio que ocurre entre el aire y el mar de dióxido de carbono y la acumulación de humus (materia orgánica) en los suelos [1].
Generating Mock Galaxy Images for the Huntsman Telescope Amir E. Bazkiaei1, Lee R. Spitler1, 2, Anthony Horton2, Wilfred T. Gee1, Steve Lee3, 4, Fergus Longbottom1 1Department of Physics & Astronomy, Macquarie University, Sydney, NSW 2109, Australia. 2Australian Astronomical Optics, Macquarie University, Sydney, NSW 1670, Australia. 3Anglo-Australian Telescope, Siding Spring Observatory, Coonabarabran, NSW 2357, Australia. 4Research School of Astronomy and Astrophysics, Australian National University, Canberra, ACT 2611, Australia.
Pathogenicity of Xylella fastidiosa subsp. multiplex isolates from Alicante outbreak (mainland Spain) on different hosts M.L. Domingo-Calap1, C.M. Aure2, I. Navarro-Herrero2, M. Simó-Esquivel1, E.G. Biosca3, M. Román-Écija4, B.B. Landa4, M. Saponari5, E. Marco-Noales2 1Tragsa, Empresa de Transformación Agraria, Delegación de Valencia, Spain. 2Centro de Protección Vegetal y Biotecnología. Instituto Valenciano de Investigaciones Agrarias (IVIA). Spain. 3Departamento de Microbiología y Ecología. Facultad de Ciencias Biológicas. Universitat de València. Spain. 4Instituto de Agricultura Sostenible, Consejo Superior de Investigaciones Científicas (IAS- CSIC), Córdoba, Spain. 5Instituto per la Protezione Sostenibile delle Piante, CNR, Bari, Italy.