NHS – Implementation and Delivery DHSC -policy and funding UK health security agency- public health surveillance RCGP- guideline and best practice BSAC – research and advocacy WHO global coordination and leadership Antimicrobial stewardship: Promoting responsible use to Combat resistance: The UK’s initial 5-year AMR strategy (2013-2018) was followed by the 20-year AMR vision and the second National action plan 2019-2024 To prevent antibiotic resistance [02] ❖AMR is creating a new generation of "superbugs" that are untreatable by current drugs, generating financial, health, food, environmental, and socioeconomic problems. [05] ❖ AMR harms public health and modern medicine by making infection treatment difficult or impossible, increasing morbidity, mortality, and healthcare costs.[04] ❖This multi-sectoral strategy coordinates efforts to optimise antimicrobial usage, minimise antibiotic use, and increase infection prevention, surveillance, and innovative therapy development.[01] ❖The partnership uses a "One Health" strategy across sectors to fight AMR, understanding its complexity and establishing realistic goals.[06] ❖The partnership seeks to build confidence among varied stakeholders while preserving their organisational independence and duties [07] Disabling Factors ❖The partnership's high-profile position in AMR and public health concerns may raise attention and pressure, altering decision-making and operations [07] ❖Guiding. The alliance has strong governance systems, with global Leaders Group quadripartite organisations coordinating and the [06] Enabling Factors ❖Ideological alignment might restrict the range of techniques and viewpoints required to solve a complicated, multi-sectoral problem.[07] Recognise and Accept the Need for Partnership Given the agencies' various aims and operational frameworks, the collaboration recognises the need for a single strategy but struggles to get partner commitment. [01] Develop Clarity and Realism of Purpose The many AMR problems may lead to unrealistic expectations, therefore realistic and adaptive goals are needed to respond to continuing reviews.[01] Ensure Commitment and Ownership Despite conflicting objectives and financial restrictions, long- term commitment demands continual involvement and resource allocation to sustain momentum.[03] Develop and Maintain Trust is fragile and needs constant communication, dispute resolution, and shared success to survive.[01] Create Clear and Robust Partnership Arrangements Formal structures must be reviewed often to adapt to changing conditions and new problems.[01] Monitor, Measure, and Learning Effective assessments and responsive initiatives depend on accurate and timely data from all partners.[01] Through stakeholder coordination, the UK AMR Partnership combats antimicrobial resistance. Despite difficulties sustaining long-term commitment and realistic expectations, it shows good teamwork, defined goals, and comprehensive monitoring. AMR prevention requires continual participation and flexibility. Aim Reduce Misuse and Overuse: Promote antimicrobial stewardship in healthcare and agriculture. [08] Aim Surveillance and Research: Increase antimicrobial resistance monitoring and encourage innovative therapy and diagnostic research.[04] Aim Increase Public and Professional Knowledge: Raise public and healthcare professional knowledge of AMR to promote appropriate antimicrobial usage. [04]