fairdataihub/poster-sentry-training-data huggingface dataset:
https://doi.org/10.53692/Anais2022COEMCO 1 Congresso Brasileiro de Educação Médica | 2020 | Virtual ANAIS DOS CONGRESSOS REGIONAIS DA ABEM 8° COEMCO “Tecnologia de Inovação no Ensino Médico em tempos atuais” Virtual, 08 de abril a 10 de abril de 2022
In silico and cheminformatics enrichment analysis to increase confidence in in vitro high-throughput screening (HTS) results: Application to Tox21 thyrotropin-releasing hormone receptor (TRHR) assay Mahmoud Shobair1*, Dan Chang1, Ryan Lougee3, Katie Paul Friedman1, Chris Grulke1, Jinghua Zhao3, Ruili Huang3, Menghang Xia3, Ann Richard1 1Ctr. for Comput. Toxicol. & Exposure, ORD, U.S. EPA; 2ORISE, Oak Ridge, TN, 3Nat. Ctr. Adv. Translational Sciences, NIH, Bethesda, MD, *Currently P&G, Cincinnati, OH Abstract #252 • Relating biochemical outputs to molecular initiating events (MIEs) and adverse outcome pathways (AOPs) is challenging, particularly when the relationship between the biochemical output and MIE is indirect, as is the case here • Tox21 thyrotropin-releasing hormone receptor (TRHR) is a potential target in the thyroid hormone AOP, but is lacking confirmatory or orthogonal assays (K. Paul Friedman, 2019) Objectives Develop and apply a structure-based data enrichment and knowledge contextualization workflow to identify likely TRHR false positives and discriminate true receptor binders identify structure-activity patterns using chemotype-enrichment analysis (Wang et al., 2019) filter noise from cytotoxicity or assay interference (Borrel et al., 2020) use 3D pharmacophore modeling to prioritize chemicals capable of binding to TRHR as well as modulators likely to interfere with binding (Kaur et al 2005) Background o TRHR is a GPCR (G protein- coupled receptor) with few known agonists or antagonists. o Assay measures agonism or antagonism for TRHR through the Gq-Ca2+ pathway. Challenge: prioritize Tox21_TRHR assay actives for hazard evaluation based on likelihood of binding to the receptor
1 Stephanie Brandt – Lecturer, MA Creative Practice for Narrative Environments, Central Saint Martins, College of Art and Design, University of the Arts, London, GB stephanie@spacepilots.net Conversation Pieces [Case Study B] Abstract The proposed project draws on habit, format, literature and space in order to construct an experimental representational system engaging with design and emotions. Photography and text are utilised to provide descriptive accounts of actions through space and time, exposing the tenuous boundaries between somebody’s life and the lived through environment. Devised through a series of dialogues the study explores the material and contextual structure of issues of habit and architecture. Trying to pervade and redefine each individual’s own daily routines and common perceptions the conversations are aiming towards both, an emotional and explanatory experience of our environment. How is space structured? By physical architectural elements such as walls or by words that describe the quality and matter of space? While both methods are understood as equally valid, this work chooses especially to explore how the re-contextualisation of words can lead to the development of new spatial qualities and emotional responses. How does this new identity make the design different from how it is historically conceived, traditionally understood and most important, conventionally used? - The aim is to structure a new imaginary scene, transforming an ordinary urban space into a sensory narrative environment, and as such conveying the [e]motions of the human subjects of the place.
Design and Integration of JUNO-OSIRIS Narongkiat Rodphai and Zhimin Wang on behalf of JUNO Collaboration Institute of High Energy Physics, Beijing, 100049, China University of Chinese Academy of Sciences, Beijing, 100049, China The Jiangmen Underground Neutrino Observatory (JUNO) is a neutrino detection experiment characterized by an acrylic sphere, measuring 35.4 me- ters in diameter, containing 20,000 tons of liquid scintillator. This sphere is encompassed by as many as 17,600 photomultiplier tubes (PMTs) with a 20- inch diameter, achieving an overall coverage of 77.9%. With these impressive capabilities, the JUNO experiment aims to achieve an exceptional effective energy resolution of 3% at 1 MeV. The Online Scintillator Internal Radioactivity Investigation System of JUNO (OSIRIS) serves as a precursor detector, around 100 meters aside in horizontal of the site of the JUNO detector underground, tasked with monitoring and examining the purity of the liquid scintillator prior to its transfer to the JUNO central detector. The OSIRIS, also as a pre-detector of JUNO, is constructed with a cylindrical acrylic vessel designed to hold 18 tons of liquid scintillator. It is situated within a 9-meter height cylindrical tank filled with 550 tons of pure water. This detector was specifically engineered to search for the fast coincidence decays of 214Bi -214Po and 212Bi -212Po in the decay chains of 238U and 232Th, respectively. OSIRIS has been designed to reach a sensitivity of 10−16 g/g for U/Th to test scintillator radiopurity to the level required for the detection of solar neutrinos. Additionally, 64 20-inch microchannel plate PMTs (MCP PMTs) were positioned around the liquid scintillator vessel to observe incoming interactions, along with an additional 12 20-inch MCP PMTs for the water Cherenkov muon veto system. The OSIRIS pre-detector has been fully constructed and integrated, pro- viding a plenty of preliminary results from the air runs. The next step in the process involves commencing the filling soon, aiming to involve an in-depth examination of the impurities within the liquid scintillator. PRESENTED AT NuPhys2023, Prospects in Neutrino Physics King’s College, London, UK, December 18–20, 2023
CD ComputaBio is a leading global company providing compelling and novel solutions in computer-aided drug design. We prioritize the integration of our advanced computational capabilities with our extensive expertise in antibody drug design to offer a range of services. These services aim to accelerate drug discovery and development processes by providing our clients with meticulously tailored, reliable, accurate projections while ensuring time and cost-effectiveness. Antibody drug design is an intricate process, entailing the creation of highly specific drugs that target antigens. These drugs are crucial in treating diseases such as cancer, autoimmune disorders, and infectious diseases. CD ComputaBio's antibody drug design services incorporate innovative technologies and advanced computational methodologies, providing our clients with high-accuracy design algorithms to facilitate the discovery and design of the most potent, selective, and safe therapeutic antibodies. Figure 1. Antibody Drug Design.( Muhammed Y, Pius M, Sani B, et al.2021) Antibody Drug Design Services Introduction of Antibody Drug Design Antibody Drug Design & Optimization Our Service
T a r t a r u g a - d e - c o u r o Identificando as 7 espécies de tartarugas marinhas T a r t a r u g a - c a b e ç u d o 5 Placas ao longo da borda do casco 2 garras nas nadadeiras dianteiras cabeça larga cor marrom avermel hada T a r t a r u g a - d e - k e m p 5 Placas ao longo da borda do casco 1 garra nas nadadeiras dianteiras 1-2 garras nas traseiras mandíbula estreita e bico curvo 2 garras nas nadadeiras dianteiras 4 pares de placas sobrepostas no casco T a r t a r u g a - o l i v a cor verde oliva 6-9 placas ao longo da borda do casco casco quase circular 1-2 garras em todas as nadadeiras rem T a r t a r u g a - a u s t r a li a n a casco redondo e achatado borda do casco fina, coberta por cutícula de cera 1 garra em cada nadadeira 4 placas na borda d casco 4 placas ao longo da borda do casco (sem sobreposição) 1 garra nas nadadeiras dianteiras par de estamas na parte dianteira da cabeça 5 cristas ao longo das costas (sem escamas) sem garras couro liso como pele entalhe em forma de dente na mandíbula superior cor preta a azul escuro cor cinza a verde oliva claro Ta rt ar ug a -d e -p en te cor marrom esverdeada escura cor cinza oliva T a r t a r u g a - v e r d e cor marrom (verde no nome se refere à gordura verde) by paige Strudwick for ICrs reefbites ref: fisheries.noaa.gov
Thermodynamic and conformational analysis of the binding of FeIIIZnII - pyrene complexes to DNA Norberto D.R.1; Bortolotto, T.1; Camargo, T.P. 1; Neves, A.2; Terenzi, H.1 1 Centro de Biologia Molecular Estrutural, Departamento de Bioquímica, Universidade Federal de Santa Catarina, 88040-970, Florianópolis - SC,Brazil 2 Laboratório de Bioinorgânica e Cristalograﬁa, Departamento de Química, Universidade Federal de Santa Catarina, 88040-900 Florianópolis - SC, Brazil Metallonucleases have a natural ability for interacting with DNA. Since binding and cleavage of DNA are at the central of action of the cellular transcription and translation, it represents an important target for therapeutic intervention and the development of diagnostic structural probes. In general, metallonucleases bind DNA in a non-covalent interaction fashion, including electrostatic or groove binding, intercalation between base-pairs, and catalysis of DNA cleavage through hydrolytic or oxidative mechanisms. Despite of the progress of recent years in this field, there are many aspects that remain unexplored. This work reports an investigation into the thermodynamic behavior of FeIIIZnII - pyrene complexes interacting with calf thymus DNA (CT-DNA) and a tentative model that aim to explain the properties used in certain families of antitumor agents was developed. The complexes FeZnLAld devoid of pyrene ligands, and FeZnLP1 and FeZnLP2, which are functionalized with one or two pyrene moieties, respectively, were examined by isothermal titration calorimetry (ITC), and compared to UV-Vis and ﬂuorescence spectroscopies. The parameters Kb, ∆Hb and n were determined using a single set of site fittings and indicate that the binding has a positive enthalpy change associated to the substitutions of pyrene, with affinity values from 4.8 x104 M-1 to 1.8x106 M-1. The results show some aspects of intercalation of a planar ligand of the complex in the DNA base pairs stack, with drastic increasing in entropic contribution. The binding free energy ∆Gb was calculated according to different representations and they are in agreement with studies of other heterovalent dinuclear complexes. Our data demonstrate that FeIIIZnII complexes modified with pyrene strongly bind to DNA, and would be important in the development of novel chemical hydrolases capable of DNA targeting and cleavage. Keywords: DNA cleavage, binding affinity, calorimetry, thermodynamics, pyrene Supported by CNPq and CAPES
Search for crop species immune to Xylella fastidiosa subsp. pauca, ST53 Montilon V.1, Cavalieri V.2, Altamura G.2, Zicca S.2, Savino V.1,3, Potere O.1, Susca L.1 1Dipartimento di Scienze del Suolo, della Pianta e degli Alimenti, Università degli Studi di Bari Aldo Moro, Bari, Italy 2CNR, Istituto per la Protezione Sostenibile delle Piante, Bari, Italy 3Centro di Ricerca, Sperimentazione e Formazione in Agricoltura “Basile Caramia”, Locorotondo (Bari), Italy
Reseña y meditación de la primera Novela Moderna: El Ingenioso Hidalgo Don Quijote de la Mancha Un dramaturgo, poeta y novelista español, autor de la novela El ingenioso hidalgo don Quijote de la Mancha, considerada como la primera novela moderna de la literatura universal, Miguel de Cervantes Saavedra fue dramaturgo, poeta y novelista español. Tuvo una vida azarosa de la que poco se sabe con seguridad. La fecha exacta de su nacimiento no se ha podido averiguar, de igual modo su fecha exacta de su fallecimiento; por el contrario, se sabe que este fue bautizado el 9 de octubre de 1547. De su muerte tan solo se supone que podría haber sido el 29 de septiembre. En 1606, la familia se mudó a Madrid. Miguel de cervantes, ya prestigioso novelista y escritor, fue redactando entonces gran parte de su producción literaria, aprovechando títulos y proyectos viejos. Tras ocho años de silencio editorial desde la publicación de la novela que lo inmortalizaría, publicó numerosas obras, una verdadera avalancha literaria. En su obra El ingenioso Hidalgo Don Quijote De La Mancha, que fue publicada en 1605 se ilustra el conflicto entre la justica idealizada de Don
! ! ! For Participatory Enquiry and Action Activities • In this 10 credit undergraduate course, students evaluate how consumer brands can be profitable and sustainable. Students work in consultancy teams on live client projects for Fast Moving Consumer Goods (FMCG) brands in luxury, beverage, and fashion markets to analyse the marketplace challenges and produce creative recommendations on how to increase sustainability whilst balancing profitability. • This course is delivered through blended learning with a combination of online active learning sessions, practitioner workshops, online activities and on campus small group tutorials. Students produce a group project for one client and compete to pitch their recommendations to the clients at a Dragons Den event. • This course provides students with the opportunity to work on a real-life sustainability challenge for an external organisation by playing the role of a marketing consultant. It tasks students to analyse and overcome the main barriers of embedding sustainability goals across their business to envision sustainable opportunities. CoDesignS ESD - is licensed under a CC BY-NC 4.0 - http://codesignsesd.org/ How the SDGs targeted were embedded The learner understands how complex supply chains create barriers and opportunities to sustainable marketing practice. The learner analyses the role businesses play in creating sustainable cities and communities. The learner produces recommendations for responsible consumption and production informed by research and evidence. How were the activities designed and delivered? Participatory enquiry and action activities Practitioner-led workshops that brief students on the client projects in preparation for the group report. Small group tutorials Students work in small group tutorials on tasks and present findings for the group project and receive formative feedback on their work from tutors. Presentation skills Students undertake an asynchronous week-long training course on presentation skills and receive formative feedback with presentation coaches. Marketing Sustainably Dr Stephanie Anderson, Dr Nilay Balkan & Dr Thomas Anker Adam Smith Business School UKPSF: A1-A4; K1-K4 Photo by Campaign Creators on Unsplash How the specific learning objectives were targeted By the end of the module the students were able to: • Analyse the levels of the marketing environment and their impact on decision- making for sustainable business practice • Produce creative and persuasive marketing communications strategy and tactics that communicate brand sustainability • Work effectively in groups to deliver a marketing project that responds to current sustainability trends in marketing practice How the specific learning objectives were assessed • A group report in which students were tasked to analyse brand propositions and produce recommendations how to enhance sustainability for their client brand. • A formative verbal group presentation that communicates the main findings and recommendations of group report. • An individual poster that tasks students to produce a set of creative recommendations to reposition the client’s brand in response to changing consumer behaviours.
Colección de ESMOS 1 Termozimas proteasas como fuente de interés industrial Olíblish Mariel Laguna Morales* iD Licenciatura en Biotecnología, Facultad de Ciencias Biológicas, Benemérita Universidad Autónoma de Puebla, Puebla, México. *Email: oliblishlaguna@gmail.com 21 de Noviembre de 2022 DOI: http://doi.org/10.5281/zenodo.7340677 Editado por: Jesús Muñoz-Rojas (Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla). Revisado por: Ligia Catalina Muñoz-Arenas (Facultad de Ingeniería Ambiental, UPAEP Universidad, Puebla, Puebla, México). Colección de ESMOS Resumen Gracias a la ciencia, poco antes de iniciar el siglo XXI, empezaron a descubrir microorganismos que viven en lugares en los cuáles no se imaginaba posible, organismos que han colonizado lugares donde se marcan los límites para otros. rompiendo y cambiando los parámetros previamente establecidos para asegurar que había vida como la
VARFISH: COMPREHENSIVE DNA VARIANT ANALYSIS FOR DIAGNOSTICS AND RESEARCH Manuel Holtgrewe, Oliver Stolpe, Mikko Nieminen, Stefan Mundlos, Alexej Knaus, Uwe Kornak, Dominik Seelow, Lara Segebrecht, Malte Spielmann, Björn Fischer-Zirnsak, Felix Boschann, Ute Scholl, Nadja Ehmke, Dieter Beule recently published as Holtgrewe, Manuel, et al. "VarFish: comprehensive DNA variant analysis for diagnostics and research." Nucleic Acids Research (2020): gkaa241.
MqsR-dependent regulon of Xylella fastidiosa modulates stress tolerance and persister cell formation Carvalho, I.G.B.1, Merfa, M.V. 2, Teixeira-Silva, N.S.1, Martins, P.M.M.1, Takita, M.A.1, and De Souza, A. S.1 1 Centro de Citricultura Sylvio Moreira Agronomic Institute (IAC), Cordeirópolis, SP, Brazil. 2 Department of Entomology and Plant Pathology, Auburn University, Auburn, AL, United States.
AMERICAN JOURNAL OF EDUCATION AND LEARNING ISSN: 2996-5128 (online) | ResearchBib (IF) = 9.918 IMPACT FACTOR Volume-2| Issue-5| 2024 Published: |30-12-2024| 1008 THE EFFECTIVENESS IN IMPLEMENTATION OF MNEMONICS TECHNIQUES IN TEACHING ENGLISH VOCABULARY https://doi.org/10.5281/zenodo.14544157 Alikberova Kamila Adkhamovna The Uzbek State World languages University, teacher Abstract The teaching and acquisition of English vocabulary remain critical components of language learning. Mnemonic techniques, which utilize associations, imagery, and structured recall, offer innovative methods to improve vocabulary retention and recall. This article examines the effectiveness of mnemonic strategies in teaching English vocabulary, focusing on their impact on learners' performance, memory retention, and engagement. By analyzing various techniques such as keyword methods, imagery associations, and acronym-based learning, the study explores the benefits and challenges of integrating mnemonics into educational settings. Key Words mnemonics, English vocabulary, teaching methods, memory techniques, language acquisition. INTRODUCTION: Vocabulary is the foundation of language learning, facilitating communication and comprehension. However, vocabulary acquisition often poses challenges for learners due to the vast number of words and their contextual nuances. Traditional rote memorization methods, though widely used, frequently fail to yield long-term retention, leading educators to explore innovative strategies. Mnemonic techniques, which rely on mental associations and cognitive linking, offer promising alternatives. By transforming abstract words into meaningful, memorable patterns, mnemonics can significantly enhance vocabulary retention and recall. This article investigates the implementation of mnemonic methods in teaching English vocabulary, focusing on their practical applications, effectiveness, and potential challenges. Objectives of the study include: 1. Evaluating the impact of mnemonic strategies on vocabulary retention. 2. Exploring different mnemonic techniques used in teaching English vocabulary.
See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/320058238 Public perception foresters of invasive ash dieback pathogen arrival in Serbia Conference Paper · September 2017 CITATIONS 0 READ 1 1 author: Some of the authors of this publication are also working on these related projects: PONTE Project H2020 View project Ljiljana Keca University of Belgrade, Faculty of Forestry, Belgrade, Serbia 123 PUBLICATIONS 101 CITATIONS SEE PROFILE All content following this page was uploaded by Ljiljana Keca on 27 September 2017. The user has requested enhancement of the downloaded file.
https://chaire-bea.vetagro-sup.fr/en/ June 2023 Species sheet – All about dogs! Author: Chaire BEA Contributing authors: Caroline Gilbert, Claire Diederich, Luc Mounier, Estelle Mollaret Graphics: Marion Weisslinger DOI : 10.5281/zenodo.12912873 You love dogs and want to know more about them, their communication signals, cognitive abilities and the way they perceive the world? Find out more in this new species sheet! This species sheet was produced with the support and proofreading of Caroline Gilbert, veterinarian, ethologist and professor at the Ecole Nationale Vétérinaire d’Alfort and Claire Diederich, veterinarian, ethologist and professor at the University of Namur.
Abstract Type: Poster Abstracts Abstract Status: Complete Abstract ID: 826054 Abstract Title: Global Search Trends: Geographic and Temporal Disparities in the Relative Search Volume for Orofacial Pain Types Authors: Junhel Dalanon, DMD, MAT, EdD; Arief Waskitho, Drdrg, SpProsK; Parimal Chavan, BDS; Swarna Lakshmi, BDS, MDS; Yoshizo Matsuka, DDS, PhD Background and Aims In the information era, seeking health information from search engines is not uncommon. These search trends or relative search volumes (RSV) have been used in the past to evaluate and forecast epidemics. This study aimed to evaluate the variations of the searches for orofacial pain types from 197 countries in a decade using Google Trends (GT). Methods A search query was done with the parameters Worldwide as location, January 1, 2010- December 31, 2019 as time range, Health as category, Web Search as database, and the search terms tooth pain (TP), jaw pain (JP), face pain (FP), head pain (HP), and mouth pain (MP) were used. Comma-separated value files were downloaded from the internet and analyzed. Search trends were expressed as RSV or the maximum popularity rate in a given search term, place, and time. Results The results of a two-way ANOVA found substantial differences on the RSV for types of pain, F (26, 1215) = 39.47, p< 0.001. Out of the 27 countries that elicited a response, HP was found to be significantly higher than any other orofacial pain type in India, Ireland, Kenya, Pakistan and South Africa. A Brown-Forsythe and Welch ANOVA found considerable disparities in search trends for various types of pain, F (4, 21) = 40.86, p< 0.001. A Dunnett’s T3 multiple comparisons test revealed that the RSV for JP (29.2±2.1, p< 0.001), FP
Student Festival of “Kavoshgarane Aseman” (explorers of the sky) Mehr observatory-IRAN Hassan Baghbani Fatemeh Hasheminasab, Mahdi Rokni, Elham Rajaei, Fatemeh Baghbani, Mina Someilipour, Ayda Rajaei, Ameneh Jamali www.skylian.org Hasan.baghbani1971@gmail.com