premise: Co-producing the film is Happy Madison, the company owned by Sandler, who has been a compatriot of Schneider's since they met early in their careers, as mutually struggling stand-up comedians in Los Angeles.
hypothesis: comedians in Los Angeles struggle
reason: When they first start out, comedians in Los Angeles will probably struggle. But once you have established yourself like these two, who started their own production company, they are not struggling at all. Just because you're a comic in LA doesn't mean you will always struggle.