Article - Billing and Coding: MolDX: Pharmacogenomics Testing (A58318)

CYP2D681226, 0070U, 0071U, 0072U, 0073U, 0074U, 0075U, 0076UlofexidineLucemyraOpioid withdrawalFDACYP2D681226, 0070U, 0071U, 0072U, 0073U, 0074U, 0075U, 0076UcevimelineEvoxacSaliva stimulantFDACYP2D681226, 0070U, 0071U, 0072U, 0073U, 0074U, 0075U, 0076UtolterodineDetrolUrinary antispasmodicFDACYP2D681226, 0070U, 0071U, 0072U, 0073U, 0074U, 0075U, 0076UvalbenazineIngrezzaVMAT2 inhibitorFDACYP3A581231tacrolimusPrografAntirejectionCPIC/FDACYP4F281479warfarinJantoven, CoumadinAnticoagulantCPIC/FDADPYD81232capecitabine, fluorouracilXeloda, Adrucil, Efudex, Fluoroplex, TolakAntineoplasticCPIC/FDAIFNL381283peginterferon alfa - 2a, peginterferon alfa - 2bPegasys, Pegasys ProClick, PegIntron, SylatronAntiviral, HCVCPICNAT281479procainamideProcan, PronestylAntiarrhythmicFDANAT281479sulfamethoxazole / trimethoprimBactrimAntibacterialFDANAT281479isoniazidNiazidAntitubercularFDANAT281479sulfasalazineAzulfidineDisease-Modifying Antirheumatic Drug (DMARD): Other - inflammatory bowel agentFDANAT281479amifampridine, amifampridine phosphateRuzurgi, FirdapseMultiple sclerosisFDANUDT1581306azathioprine, mercaptopurine, thioguanineAzasan, Purixan, TabloidAntineoplasticCPIC/FDASLCO1B181328simvastatin, atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatinFloLipid, Zocor, Lipitor, Lescol, Mevacor, Altoprev, Altocor, Livalo, Zypitamag, Pravachol, CrestorAntihyperlipidemicCPIC/FDATPMT81335, 0034U, 0286Uazathioprine, mercaptopurine, thioguanineAzasan, Purixan, TabloidAntineoplasticCPIC/FDAUGT1A181350belinostat, irinotecan, nilotinib, pazopanib, Sacituzumab Govitecan-HziyBeleodaq, Camptosar, Tasigna, Votrient, TrodelvyAntineoplasticFDAUGT1A181350atazanavirReyatazAntiretroviral, HIVCPICUGT2B1781479belzutifanWeliregAntineoplasticFDAVKORC181355warfarinJantoven, CoumadinAnticoagulantCPIC/FDATable 2 represents other relevant gene/drug associations that are not related to metabolism from CPIC and FDA sources.Table 2.This table represents other relevant therapeutic gene/drug associations from CPIC and FDA sources.GeneCPT Code(s)Generic NameTrade Name(s)Intended use for Drug(s)GuidanceAPOE81401lecanemabLeqembiAlzheimers DiseaseFDACACNA1S81479desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane, succinylcholineSuprane, Ethrane, Fluothane, Forane, Penthrox, Ultane, Anectine, QuelicinVolatile anestheticCPICG6PD81247rasburicase, pegloticaseElitek, KrystexxaHyperuricemiaCPICG6PD81247dapsoneAccone, AvlosulfonAntibacterialCPICG6PD81247primaquine, tafenoquineJasoprim, ArakodaAntimalarialCPICHLA - A81381tebentafuspKimmtrakAntineoplasticFDAHLA - A81381, 81374carbamazepineTegretolAnticonvulsantCPIC/FDAHLA - B81381, 81374carbamazepine, fosphenytoin, oxcarbazepine, phenytoinTegretol, Cerebyx, Trileptal, DilantinAnticonvulsantCPIC/FDAHLA - B81381, 81374pazopanibVotrientAntineoplasticFDAHLA - B81381, 81374abacavirZiagenAntiretroviral; HIVCPIC/FDAHLA - B81381, 81374allopurinolAloprim, ZyloprimHyperuricemiaCPIC/FDAHLA - DQA181377, 81383lapatinibTykerbAntineoplasticFDAHLA - DRB181377, 81383lapatinibTykerbAntineoplasticFDARYR181406desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane, succinylcholineSuprane, Ethrane, Fluothane, Forane, Penthrox, Ultane, Anectine, QuelicinVolatile anestheticCPICCoveredmultigene panels with intended usesPanels with a specific intended use such as major depressive disorder (MDD) or neuropsychiatric must include relevant ICD-10 codes.ICD-10 codes associated with intended usesIntended UseICD-10 codesDescriptionMDDF32.1Major depressive disorder, single episode, moderateMDDF32.2Major depressive disorder, single episode, severe without psychotic featuresMDDF32.3Major depressive disorder, single episode, severe with psychotic featuresMDDF32.4Major depressive disorder, single episode, in partial remissionMDDF33.1Major depressive disorder, recurrent, moderateMDDF33.2Major depressive disorder, recurrent severe without psychotic featuresMDDF33.3Major depressive disorder, recurrent, severe with psychotic symptomsMDDF33.41Major depressive disorder, recurrent, in partial remissionNeuropsychiatricF20.0Paranoid schizophreniaNeuropsychiatricF20.1Disorganized schizophreniaNeuropsychiatricF20.2Catatonic schizophreniaNeuropsychiatricF20.3Undifferentiated schizophreniaNeuropsychiatricF20.5Residual schizophreniaNeuropsychiatricF20.81Schizophreniform disorderNeuropsychiatricF20.89Other schizophreniaNeuropsychiatricF31.0Bipolar disorder, current episode hypomanicNeuropsychiatricF31.11Bipolar disorder, current episode manic without psychotic features, mildNeuropsychiatricF31.12Bipolar disorder, current episode manic without psychotic features, moderateNeuropsychiatricF31.13Bipolar disorder, current episode manic without psychotic features, severeNeuropsychiatricF31.2Bipolar disorder, current episode manic severe with psychotic featuresNeuropsychiatricF31.31Bipolar disorder, current episode depressed, mildNeuropsychiatricF31.32Bipolar disorder, current episode depressed, moderateNeuropsychiatricF31.4Bipolar disorder, current episode depressed, severe, without psychotic featuresNeuropsychiatricF31.5Bipolar disorder, current episode depressed, severe, with psychotic featuresNeuropsychiatricF31.61Bipolar disorder, current episode mixed, mildNeuropsychiatricF31.62Bipolar disorder, current episode mixed, moderateNeuropsychiatricF31.63Bipolar disorder, current episode mixed, severe, without psychotic featuresNeuropsychiatricF31.64Bipolar disorder, current episode mixed, severe, with psychotic featuresNeuropsychiatricF31.71Bipolar disorder, in partial remission, most recent episode hypomanicNeuropsychiatricF31.73Bipolar disorder, in partial remission, most recent episode manicNeuropsychiatricF31.75Bipolar disorder, in partial remission, most recent episode depressedNeuropsychiatricF31.77Bipolar disorder, in partial remission, most recent episode mixedNeuropsychiatricF40.11Social phobia, generalizedNeuropsychiatricF41.0Panic disorder [episodic paroxysmal anxiety]NeuropsychiatricF41.1Generalized anxiety disorderNeuropsychiatricF41.3Other mixed anxiety disordersNeuropsychiatricF41.8Other specified anxiety disordersNeuropsychiatricF43.11Post-traumatic stress disorder, acuteNeuropsychiatricF43.12Post-traumatic stress disorder, chronicNeuropsychiatricF60.5Obsessive-compulsive personality disorderNeuropsychiatricF90.0Attention-deficit hyperactivity disorder, predominantly inattentive typeNeuropsychiatricF90.1Attention-deficit hyperactivity disorder, predominantly hyperactive typeNeuropsychiatricF90.2Attention-deficit hyperactivity disorder, combined typeNeuropsychiatricF90.8Attention-deficit hyperactivity disorder, other type