Article - Billing and Coding: Pharmacogenomics Testing (A58812)

Suprane, Ethrane, Fluothane, Forane, Penthrox, Ultane, Anectine, QuelicinSLCO1B181328, 0423UStatins (class): simvastatin, pravastatin, atorvastatin, lovastatin, rosuvastatin, fluvastatin, pitavastatinZocor, FloLipid, Pravachol, Lipitor, Altoprev, Crestor, Lescol, LivaloNUDT1581306, 0286UThiopurines (class): mercaptopurine, azathioprine, thioguaninePurixan, Azasan, TabloidTPMT81335Thiopurines (class): mercaptopurine, azathioprine, thioguaninePurixan, Azasan, TabloidUGT1A181350atazanavirReyatazMT-RNR181401Aminoglycosides (class): gentamicin, amikacin, paromomycin, streptomycin, plazomicin, tobramycinArikayce, ZemdriABCG20193U, 0423UrosuvastatinCrestorTable 2.Table ofPHARMACOGENOMICassociationsfrom the FDA for which the data support therapeutic recommendations or a potential impact on safety or response (last updated October 26, 2022):GeneCPT CodeDrugBrand NameAffected Subgroups+BCHE81479mivacuriumMivacurium chlorideintermediate or poor metabolizersBCHE81479succinylcholineAnectineintermediate or poor metabolizersCYP2B681479, 0423UefavirenzSustivapoor metabolizersCYP2C1981225, 81418, 0423UbrivaracetamBriviactintermediate or poor metabolizersCYP2C1981225, 81418, 0423UcitalopramCelexapoor metabolizersCYP2C1981225, 81418, 0423UclobazamOnfiintermediate or poor metabolizersCYP2C1981225, 81418, 0423UclopidogrelPlavixintermediate or poor metabolizersCYP2C1981225, 81418, 0423UflibanserinAddyipoor metabolizersCYP2C1981225, 81418, 0423UpantoprazoleProtonixIntermediate or poor metabolizersCYP2C1981225, 81418, 0423UvoriconazoleVfendintermediate or poor metabolizersCYP2C1981225, 81418, 0423UabrocitinibCibinqopoor metabolizersCYP2C1981225, 81418, 0423UmavacamtenCamzyosintermediate or poor metabolizersCYP2C19 and/or UGT2B1781225, 81418, 0423UbelzutifanCibinqopoor metabolizersCYP2C981227, 0423UcelecoxibCelebrexpoor metabolizers or *3 carriersCYP2C981227, 0423UdronabinolMarinolintermediate or poor metabolizersCYP2C981227, 0423UerdafitinibBalversa*3/*3 (poor metabolizers)CYP2C981227, 0423UflurbiprofenAnsaidpoor metabolizers or *3 carriersCYP2C981227, 0423UfosphenytoinCerebyxintermediate or poor metabolizersCYP2C981227, 0423UmeloxicamMobicpoor metabolizers or *3 carriersCYP2C981227, 0423Unateglinidepoor metabolizersCYP2C981227, 0423UphenytoinDilantinintermediate or poor metabolizersCYP2C981227, 0423UpiroxicamFeldeneintermediate or poor metabolizersCYP2C981227, 0423UsiponimodMayzentintermediate or poor metabolizersCYP2C981227, 0423UwarfarinCoumadinintermediate or poor metabolizersCYP2D681226, 81418, 0423UamphetamineAdderallpoor metabolizersCYP2D681226, 81418, 0423UaripiprazoleAbilifypoor metabolizersCYP2D681226, 81418, 0423Uaripiprazole lauroxilAristadapoor metabolizersCYP2D681226, 81418, 0423UatomoxetineStratterapoor metabolizersCYP2D681226, 81418, 0423UbrexpiprazoleRexultipoor metabolizersCYP2D681226, 81418, 0423UclozapineClozaril, FazaClo, Versaclozpoor metabolizersCYP2D681226, 81418, 0423Ucodeineultrarapid metabolizers, poor metabolizersCYP2D681226, 81418, 0423UdeutetrabenazineAustedopoor metabolizersCYP2D681226, 81418, 0423UeliglustatCerdelgaultrarapid, normal, intermediate, or poor metabolizersCYP2D681226, 81418, 0423UgefitinibIressapoor metabolizersCYP2D681226, 81418, 0423UIloperidoneFanaptpoor metabolizersCYP2D681226, 81418, 0423UlofexidineLucemyrapoor metabolizersCYP2D681226, 81418, 0423UmeclizineAntivertultrarapid, intermediate, or poor metabolizersCYP2D681226, 81418, 0423UmetoclopramideReglanpoor metabolizersCYP2D681226, 81418, 0423UpimozideOrappoor metabolizersCYP2D681226, 81418, 0423UpropafenoneRythmolpoor metabolizersCYP2D681226, 81418, 0423UtetrabenazineXenazinepoor metabolizersCYP2D681226, 81418, 0423UthioridazineMellarilpoor metabolizersCYP2D681226, 81418, 0423UtramadolUltramultrarapid metabolizers, or poor metabolizersCYP2D681226, 81418, 0423UvalbenazineIngrezzapoor metabolizersCYP2D681226, 81418, 0423UvenlafaxineEffexorpoor metabolizersCYP2D681226, 81418, 0423UvortioxetineTrintellixpoor metabolizersCYP2D681226, 81418, 0423UcarvedilolCoregpoor metabolizersCYP2D681226, 81418, 0423UcevimelineEvoxacpoor metabolizersCYP2D681226, 81418, 0423UperphenazineTrilafonpoor metabolizersCYP2D681226, 81418, 0423UtolterodineDetrolpoor metabolizersCYP2D681226, 81418, 0070U, 0071U, 0072U, 0073U, 0074U, 0075U, 0076U, 0423UoliceridineOlinvykpoor metabolizersCYP2D681226, 81418, 0070U, 0071U, 0072U, 0073U, 0074U, 0075U, 0076U, 0423UpitolisantWakixpoor metabolizersCYP3A581231, 0423UtacrolimusPrografintermediate or normal metabolizersCYP4F281479warfarinCoumadinV433M variant carriersDPYD81232capecitabineXelodaintermediate or poor metabolizersDPYD81232fluorouracilFluoroplex, Tolak, Efudexintermediate or poor metabolizerHLA-A81381, 81374, 0423UcarbamazepineTegretol*31:01 allele positiveHLA-B81381, 81374, 0423UabacavirZiagen*57:01 allele positiveHLA-B81381, 81374, 0423UcarbamazepineTegretol*15:02 allele positiveHLA-B81381, 81374, 0423UfosphenytoinCerebyx*15:02 allele positiveHLA-B81381, 81374, 0423UallopurinolZyloprim, Aloprim*58:01 allele positiveHLA-B81381, 81374, 0423UoxcarbazepineTrileptal, Oxtellar*15:02 allele positiveHLA-B81381, 81374, 0423UpazopanibVotrient*57:01 allele positiveHLA-B81381, 81374, 0423UphenytoinDilantin*15:02 allele positiveHLA-DQA181383, 81377lapatinibTykerb*02:01 allele positiveHLA-DRB181383, 81377lapatinibTykerb*07:01 allele positiveNAT281479amifampridineFirdapse, Ruzurgipoor metabolizersNAT281479amifampridine phosphatepoor metabolizersNonspecific (NAT)81479isoniazidpoor metabolizersNonspecific (NAT)81479procainamidePronestyl, Procanpoor metabolizersNonspecific (NAT)81479sulfamethoxazole and trimethoprimSulfatrim, Bactrimpoor metabolizersNonspecific (NAT)81479sulfasalazineAzulfidinepoor metabolizersSLCO1B181328, 0423UsimvastatinFloLipid, Zocor521 TC or 521 CC (intermediate or poor function transporters)NUDT15 and/orTPMT81306, 81335, 0286UazathioprineImuran, Azasanintermediate or poor metabolizersNUDT15 and/orTPMT81306, 81335, 0286UmercaptopurinePurixan, Purinetholintermediate or poor metabolizersNUDT15 and/orTPMT81306, 81335, 0286UthioguanineTabloidintermediate or poor metabolizersUGT1A181350belinostatBeleodaq*28/*28 (poor metabolizers)UGT1A181350irinotecanCamptosar