ethicalabs/Research-Intent-Collab huggingface dataset:
ADDITIVE MANUFACTURING THROUGH 3D PRINTING FDMFUSED DEPOSIT MODELING OF PRESS BUSH

This paper highlights both theoretically and experimentally the use of 3D printing technology, using Fused Deposition Modeling technology. The part that has been printed is the press bushing for the flushing head of the FA100, FA125, FH150 and FG40 water drilling rigs. The proposed work falls within the framework of green technologies, friendly to the environment and within the projects for the realization of industrial parts by additive methods, respectively by 3D printing. This technology offers many advantages compared to the classic manufacturing technologies of that part both in terms of harmful emissions, high energy consumption and the final price of the part.
&lt;b&gt;The Role of Nursing Leadership in Promoting Patient Safety Culture and Quality of Care in Tertiary Hospitals of South Punjab&lt;/b&gt;

Background: Nursing leadership plays a critical role in shaping patient safety culture and influencing the quality of care in healthcare systems, particularly in resource-constrained tertiary hospital settings. Objective: To assess the association between nursing leadership, patient safety culture, and quality of care among nurses working in tertiary care hospitals of South Punjab, Pakistan. Methods: A quantitative cross-sectional study was conducted among 141 nurses selected through convenience sampling from multiple public-sector tertiary hospitals. Data were collected using a structured questionnaire assessing leadership, safety culture, and quality of care. Descriptive statistics, chi-square tests, and Pearson correlation analyses were performed using SPSS version 27, with significance set at p &lt; 0.05. Results: Nursing leadership showed a strong positive correlation with patient safety culture (r = 0.680, p &lt; 0.001) and quality of care (r = 0.610, p &lt; 0.001). Patient safety culture was also significantly correlated with quality of care (r = 0.630, p &lt; 0.001). Chi-square analysis demonstrated significant associations between leadership and safety culture (χ² = 32.45, p &lt; 0.001) and quality of care (χ² = 28.67, p &lt; 0.001). Descriptive findings indicated generally positive perceptions, although gaps were noted in non-punitive error reporting and resource availability. Conclusion: Nursing leadership is significantly associated with improved patient safety culture and quality of care. Strengthening leadership practices and supportive organizational environments may enhance patient outcomes in tertiary healthcare settings.
Implementing clinical guidelines in the treatment of hypertension in general practice: Evaluation of patient outcome related to implementation of a computer-based clinical decision support system

To evaluate the implementation of clinical guidelines for hypertension in general practice by use of a computer-based clinical decision support system (CDSS) and a specific implementation strategy. Evaluation of patient outcome.Randomised study with health centres as units. The intervention group had the CDSS installed and made ready for use, doctors and assistants were trained and received a user-manual, the doctors were offered telephone repetitions, a seminar in risk intervention and, at the same seminar, further demonstration of the CDSS. The doctors received baseline registrations with information of how they treated their own hypertensive patients, and use of the CDSS was checked repeatedly.General practice in Sør- and Nord-Trøndelag counties in Norway, 380,000 inhabitants.Seventeen health centres with 24 doctors and 984 patients in the intervention group. Data from 879 patients used in the final analyses. Twelve health centres with 29 doctors and 1255 patients in the control group. Data from 1119 patients used in the final analyses.After an intervention period of 18 months, group differences in level of systolic and diastolic blood pressure, serum cholesterol, body mass index, and risk score for myocardial infarction were calculated, as well as group differences in fractions of smokers.Significant group difference in favour of intervention group: diastolic blood pressure 1 mmHg (95% CI -1.89, -0.17). However, a significant baseline difference in systolic blood pressure in favour of control group of 2.7 mmHg (95% CI 1.0, 4.5) had been reduced to 1.2 mmHg (95% CI -0.6, 3.0) after intervention.Implementation of clinical guidelines in the treatment of hypertensive patients in general practice by means of a CDSS and several other procedures for implementation did not affect patient outcome in any clinically significant way.
Modulation of Galactic Cosmic Rays in the Heliosphere

Observations of the intensity of galactic cosmic rays and anomalous components near earth and in the outer heliosphere are providing important tests for theories of solar modulation. The most recent observations show effects that seem to require that models for modulation include gradient and curvature drifts as well as the conventional processes of convection, adiabatic deceleration, and diffusion. New observations are required to define the interplay of these processes in the three-dimensional heliosphere.
The Cosmic Microwave Background Anisotropy Power Spectrum Measured by Archeops

We present a determination by the Archeops experiment of the angular power spectrum of the cosmic microwave background anisotropy in 16 bins over the multipole range &ell; = 15 - 350. Archeops was conceived as a precursor of the Planck HFI instrument by using the same optical design and the same technology for the detectors and their cooling. Archeops is a balloon-borne instrument consisting of a 1.5 m aperture diameter telescope and an array of 21 photometers maintained at ~100 mK that are operating in 4 frequency bands centered at 143, 217, 353 and 545 GHz. The data were taken during the Arctic night of February 7, 2002 after the instrument was launched by CNES from Esrange base (Sweden). The entire data cover ~30% of the sky. This first analysis was obtained with a small subset of the dataset using the most sensitive photometer in each CMB band (143 and 217 GHz) and 12.6% of the sky at galactic latitudes above 30 degrees where the foreground contamination is measured to be negligible. The large sky coverage and medium resolution (better than 15 arcmin) provide for the first time a high signal-to-noise ratio determination of the power spectrum over angular scales that include both the first acoustic peak and scales probed by COBE/DMR. With a binning of  &ell; = 7 to 25 the error bars are dominated by sample variance for &ell; below 200. A companion paper details the cosmological implications.
Sampling - reconstruction procedure with jitter of markov continuous processes formed by stochastic differential equations of the first order

To describe sampling - reconstruction procedure (SRP) of Markov processes  the conditional mean rule is used. There are two types of stochastic  differential equations under consideration: 1) linear with varying in time  coefficients; 2) non linear coefficients. In the first Gaussian case it is  sufficiently to obtain the expression for conditional covariance function  and then to calculate the reconstruction function and the error  reconstruction function. In the case 2 it is necessary to obtain the  solution of the corresponding Fokker - Plank - Kolmogorov equation for the  conditional probability density functions (pdf). We obtain the required  conditional pdf with two fixed samples and then determine the reconstruction  function and the error reconstruction function. The jitter effect is  described by random variable with the beta-distribution. Some examples are  given.
Risk Factors for Lower Limb Injury in Female Team Field and Court Sports: A Systematic Review, Meta-analysis, and Best Evidence Synthesis

Identifying risk factors for lower limb injury is an important step in developing injury risk reduction training and testing for player monitoring. Female athletes are distinct from male athletes, warranting separate investigation into risk factors.To systematically review the literature and synthesise the evidence for intrinsic risk factors for lower limb injury in female team field and court sports.Five online databases were searched from inception to April 2020. To be eligible for inclusion, studies were required to be a prospective study presenting intrinsic risk factors for lower limb injury in female team field or court sport athletes. Risk of bias was assessed using the Quality of Prognosis Studies tool.Sixty-nine studies, capturing 2902 lower limb injuries in 14,492 female athletes, and analysing 80 distinct factors met the inclusion criteria. Risk factors for any lower limb injury included greater body mass (standardised mean difference [SMD] = 0.24, 95% confidence interval [95% CI]  0.18-0.29), greater body mass index (BMI) (SMD = 0.22, 95% CI  0.05-040), older age (SMD = 0.20, 95% CI  0.09-0.31), greater star excursion balance test (SEBT) anterior reach distance (SMD = 0.18, 95% CI   0.12-0.24), and smaller single-leg hop distance (SMD = - 0.09, 95% CI  - 0.12 to - 0.06). Lower knee injury and osteoarthritis outcome score (KOOS) increased the risk of knee injury. Anterior cruciate ligament (ACL) injury risk factors included prior ACL injury (odds ratio [OR] = 3.94, 95% CI  2.07-7.50), greater double-leg postural sway (SMD = 0.58, 95% CI   0.02-1.15), and greater body mass (SMD = 0.25, 95% CI  0.12-0.39). Ankle injury risk factors included smaller SEBT anterior reach distance (SMD = - 0.13, 95% CI  - 0.14 to - 0.13), greater single-leg hop distance asymmetry (OR = 3.67, 95% CI   1.42-9.45), and slower agility course time (OR = 0.20, 95% CI 0.05-0.88). Remaining factors were not associated with injury or had conflicting evidence.Prior injury, older age, greater body mass, and greater BMI are risk factors for lower limb injury in female athletes. Limited evidence showed an association between KOOS, SEBT anterior reach, single-leg hop distance and asymmetry, double-leg postural sway, agility, and lower limb injury.CRD42020171973.
Integrating Artificial Intelligence in Electric Vehicles and Optimizing Logistics for Sustainable Transportation

Over the past century, transportation evolved from carriages to steam engines and then to Internal Combustion Engine Vehicles (ICEVs). Despite advancements, ICEVs have significantly contributed to environmental pollution and greenhouse gas emissions. Electric Vehicles (EVs) emerged as a quieter, simpler alternative but faced limitations in cost and application. Recently, Artificial Intelligence (AI) integration in EVs has enhanced safety, efficiency, and sustainability. This chapter explores how AI, applied to EVs and logistics, improves transportation sustainability by enhancing energy management, range estimation, and charging efficiency. AI also optimizes logistics, reducing emissions and costs. However, challenges like privacy, data security, and ethical concerns persist. The chapter concludes with future trends in AI-driven sustainable transportation, highlighting ongoing research and emerging technologies that promise a more sustainable and resilient system.
ROLES OF WOMEN IN BUILDING PEACE, CONFLICT RESOLUTION AND HAPPINESS IN NIGERIA’S CONFLICT AREAS

United Nations Organisation outlined measures for promoting women’s participation in peace and development efforts through the forward looking strategies for advancement of women participation for conflict resolution and peace building, especially in conflict areas. The purpose of the research is to show how women in Nigeria’s conflict areas have contributed and could increase their contribution to conflict resolution and peace building .The research investigates the following, nature of conflict and insecurity challenges in Nigeria, how women and girls are affected and how they constitute asset or obstacle to peace and happiness in society. Using the content analysis research method the research found the occurrence of sexual and gender based violence in conflicts and insecurity situations in Nigeria. Parties to conflicts and insecurity benefit strategically from the subjugation of women .The research concluded and showed through its recommendations how women can continue to resolve conflicts and build peace in conflict areas in line with the third goal of the United Nations Organisations’ Forward Looking Strategies for advancement of women’s participation for conflict resolution and peace building .
UNCERTAINTY QUANTIFICATION AND DECOMPOSITION THROUGH BAYESIAN DEEP LEARNING FOR BIG DATA SATELLITE REMOTE SENSING PROBLEMS

This dissertation demonstrates the value of uncertainty quantification and decomposition for big data satellite remote sensing problems in both classification and regression settings. Bayesian deep learning methods are applied to a classification and a regression problem with datasets in excess of 14 million samples, quantifying total uncertainty and decomposing the total uncertainty into separate components. In all cases, Bayesian probabilistic models perform comparably to their deterministic counterparts but provide valuable additional information in the form of quantified uncertainty that can be decomposed by source. The value of the quantified uncertainty is demonstrated by analyzing the relationship between model errors, uncertainty and underlying physical properties of the observational data and the atmosphere. Quantitative analysis of accuracy, error, and uncertainty metrics is illustrated through use cases for quantified uncertainty that informs decisions concerning high uncertainty predictions, model selection, targeted data analysis, data collection/processing and virtual concept drift (distribution shift) detection. These methods apply wherever deterministic deep learning is currently being applied or where it might be applied in the future. The work presented in this dissertation has the potential to positively affect joint all-domain command and control (JADC2) in both present-day and future operations.
The effect of self-aggregation on the determination of the kinetic and thermodynamic constants of the network of chemical reactions in 3-glucoside anthocyanins

The six most common 3-glucoside anthocyanins, pelargonidin-3-glucoside, peonidin-3-glucoside, delphinidin-3-glucoside, malvidin-3-glucoside, cyanidin-3-glucoside and petunidin-3-glucoside were studied in great detail by NMR, UV-vis absorption and stopped flow. For each anthocyanin, the thermodynamic and kinetic constants of the network of chemical reactions were calculated at different anthocyanin concentration, from 6 × 10⁻⁶ M up to 8 × 10⁻⁴ M; an increasing of the flavylium cation acidity constant to give quinoidal base and a decreasing of the flavylium cation hydration constant to give hemiketal were observed by increasing the anthocyanin concentration. These effects are attributed to the self-aggregation of the flavylium cation and quinoidal base, which is stronger in the last case. The UV-vis and ¹H NMR spectral variations resulting from the increasing of the anthocyanin concentration were discussed in terms of two aggregation models; monomer-dimer and isodesmic, the last one considering the formation of higher order aggregates possessing the same aggregation constant of the dimer. The self-aggregation constant of flavylium cation at pH=1.0, calculated by both models increases by increasing the number of methoxy (-OCH₃) or hydroxy (-OH) substituents following the order: myrtillin (2 -OH), oenin (2 -OCH₃), 3-OGl-petunidin (1 -OH, 1 -OCH₃), kuromanin (1 -OH), 3-OGl-peonidin (1 -OCH₃) and callistephin (none). Evidence for flavylium aggregates possessing a shape between J and H was achieved, as well as for the formation of higher order aggregates.
Abstract 1927: Epigenetic CRISPR screen identifies chromatin regulators essential for ovarian cancer spheroid formation.

Abstract                                        Background:                     Cancer stem-like cells (CSCs) contribute to recurrence and chemoresistance in high-grade serous ovarian cancer (HGSOC). Spheroid formation in ultra-low attachment (ULA) cultures models CSC self-renewal, yet the epigenetic regulators and molecular dependencies sustaining this 3D phenotype remain largely undefined.                                                           Methods:                     A focused CRISPR knockout screen targeting 800 epigenetic and chromatin regulators was performed in OVCAR-3 spheroids. sgRNA enrichment after 3D selection identified genes essential for spheroid growth. Top candidates were functionally validated in BRCA1-wildtype, BRCA1-LOH, and BRCA1-mutant cell lines by assessing spheroid morphology, compaction, viability, and proliferative behavior.                                                           Results:                     The screen identified a high-confidence set of regulators required for spheroid formation, including DNA damage response genes (BRCA1, PARG), Polycomb complex members (SUZ12, BMI1), RNA-binding proteins (NCL, SYNCRIP), and cell cycle regulators (CDK2, PBRM1). These hits converge on chromatin remodeling, histone methylation, and transcriptional control pathways, linking epigenetic regulation with DDR signaling.Functional assays revealed a striking BRCA1 dependency: while BRCA1-WT and LOH cell lines formed compact, viable spheroids, BRCA1-mutant cells produced disorganized, loosely aggregated, hyperproliferative structures with poor architectural integrity. This indicates that BRCA1 is essential not for proliferation per se, but for establishing and maintaining 3D stem-like organization. Integration of the CRISPR hits with phenotypic outcomes suggests a cooperative network between DDR factors, RNA-binding regulators, and chromatin modifiers in sustaining CSC-like behavior.                                                           Conclusions:                     Our findings demonstrate that BRCA1 function underpins the epigenetic and chromatin-based control of spheroid architecture, revealing a mechanistic link between DNA repair fidelity, chromatin integrity, and cancer stemness. The identified vulnerabilities highlight potential therapeutic targets for BRCA1-deficient ovarian and breast cancers.                                                           Citation Format:                     Deren Demirel Yavuz, Irem Durmaz Sahin. Epigenetic CRISPR screen identifies chromatin regulators essential for ovarian cancer spheroid formation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2026; Part 1 (Regular Abstracts); 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86(7 Suppl):Abstract nr 1927.
Fundamental Principles of Space Resources Exploitation: A Recent Development of International and Municipal Law

Space law is normally referred to international space law. As national space activities develop, however, national space laws have been legislated in many countries for the development of space resources. These are used to present conflicting cases between national and international space law (corpus juris spatialis internationalis) on the interpretation of space resource exploitation. This study is devoted to bridging the gap between these two legal systems. In this paper, the author will critically review the fundamental principles of space resource exploitation under international law and suggest a direction for setting up national space laws for future space resources. This paper is composed of seven parts, including a short Introduction and Conclusion. Part two will discuss acts pertaining to asteroid resources. Part three will deal with res extra commercium. Part four will analyze the non-appropriation principle. Part five will look into the common heritage of mankind. Part six will investigate res nullius humanitatus.
TXO: Transcription-Only genetic circuits as a novel cell-free approach for Synthetic Biology

Abstract                 While synthetic biology represents a promising approach to solve real-world problems, the use of genetically modified organisms is a cause of legal and environmental concerns. Cell-free systems have emerged as a possible solution but much work is needed to optimize their functionality and simplify their usage for Synthetic Biology. Here we present TXO, transcription-only genetic circuits, independent of translation or post-translation maturation. RNA aptamers are used as reaction output allowing the generation of fast, reliable and simple-to-design transcriptional units. TXO cell-free reactions and their possible applications are a promising new tool for fast and simple bench-to-market genetic circuit and biosensor applications.
The dissolution of metal carbonate precipitation under the external electric and magnetic fields: reactive force field molecular dynamics simulation

Abstract                The dissolution of metal carbonates holds a pivotal role in diverse industrial processes, environmental occurrences, and geological formations. Grasping the fundamental mechanisms underlying these processes is imperative for enhancing industrial applications and mitigating environmental impacts. Herein, we undertake a thorough investigation employing reactive forcefieldmolecular dynamics simulations to delve into the dissolution process of metal carbonates. These simulations afford profound insights into the mechanisms and kinetics governing the process across various conditions, encompassing temperature, acidity, and external electric and magnetic fields. Although temperature itself exerts a limited influence, the study reveals a synergistic enhancement of metal carbonate dissolution kinetics when temperature is combined with static electric and magnetic fields. Our revelations offer enlightening perspectives on the intricate interplay of factors shaping dissolution processes, laying the foundation for future inquiries in this domain.