ethicalabs/Research-Intent-Collab huggingface dataset:
Non-genetic heterogeneity criticality and cell differentiation

The different cell types in a living organism acquire their identity through the process of cell differentiation in which the multipotent progenitor cells differentiate into distinct cell types. Experimental evidence and analysis of large-scale microarray data establish the key role played by a two-gene motif in cell differentiation in a number of cell systems. The two genes express transcription factors which repress each other's expression and autoactivate their own production. A number of theoretical models have recently been proposed based on the two-gene motif to provide a physical understanding of how cell differentiation occurs. In this paper, we study a simple model of cell differentiation which assumes no cooperativity in the regulation of gene expression by the transcription factors. The latter repress each other's activity directly through DNA binding and indirectly through the formation of heterodimers. We specifically investigate how deterministic processes combined with stochasticity contribute in bringing about cell differentiation. The deterministic dynamics of our model give rise to a supercritical pitchfork bifurcation from an undifferentiated stable steady state to two differentiated stable steady states. The stochastic dynamics of our model are studied using the approaches based on the Langevin equations and the linear noise approximation. The simulation results provide a new physical understanding of recent experimental observations. We further propose experimental measurements of quantities like the variance and the lag-1 autocorrelation function in protein fluctuations as the early signatures of an approaching bifurcation point in the cell differentiation process.
Indonesian Women's Right to Gender Equality and Sexual Reproductive Health; a Human Right Perspective

In a legal and social context, the reproduction right is a problem of power relations and society, particularly laws. Women usually remain silent since they lack power. Not because of their personalities, but due to the influence of politics, economics, and society. Their interactions with men, their families, their friends, and society are all crucial. Gender-based laws are the result of communal attitudes toward women, gender, and sex. This results in a variety of forms of violence during implementation. The study adopts a description-based approach, and the analysis of how norms are applied to positive laws is the main research objective. Normative juridical research is well-versed in this approach. In order to develop the idea of gender equity, the study examines how human rights are applied and whether they are acceptable for women's reproductive rights based on gender. Additionally, the statuary approach, conceptual approach, and comparative technique are used in this type of research. These methods are used to identify problems and possible solutions. The results of the study indicate that when it comes to the safety or health of their reproductive systems, women have a special right to protection at work and in their professions Gender inequality is a cause of violations of women's human rights. Gender discrimination and violence against women in Indonesia are still pervasive.
Lost Profits and Unjust-Enrichment Damages for the Misappropriation of Trade Secrets

This paper analyzes civil remedies for the misappropriation of trade secrets. We study the impact of different damages doctrines on firms’ competitive behavior and on the incentives to misappropriate. We find that the owner of a trade secret is better off under the lost-profits regime, while the rival (independently of whether he obtained the technology by misappropriation or by independent development) is better off under the unjust-enrichment regime. The unjust-enrichment regime provides fewer incentives to misappropriate and yields a smaller market deadweight loss. The choice between the two rules essentially depends on the lawmaker’s goal.
Assessing the role of aquatic tourism in enhancing economic resilience and biodiversity conservation in marine protected areas

In Marine Protected Areas (MPAs), aquatic tourism can contribute to economic resilience and biodiversity conservation. This research paper will evaluate the value of aquatic tourism in these regions, with specific respect to its contribution to the sustainable development of the economy and to the conservation of marine ecosystems. The study is based on the concept of a blue economy, which focuses on the sustainable use of marine resources to develop the economy. These goals will help to assess the economic effects of aquatic tourism on the local population in MPAs, analyze the opportunities of tourism to help in conservation activities and also to find out which issues and opportunities can be used to balance tourism and conservation objectives. The approaches will involve both economic analysis and ecological studies, as well as interviews with the stakeholders, to obtain data on both economic and environmental impacts. The findings indicate that properly developed aquatic tourism in MPAs may have a huge economic potential, such as creating employment opportunities, developing infrastructure, and leveraging on tourism activities to boost revenue. Also, as part of conservation, it can help achieve the better marine biodiversity by providing the funding to conservation initiatives and increasing awareness among the visitors. Nevertheless, the paper also emphasizes that there should be effective management measures in place to deter the occurrence of over-tourism and to counteract the possible negative consequences on the ecological conditions.
Convergence Results for Optimal Control Problems Governed by Elliptic Quasivariational Inequalities

We consider an optimal control problem $\cQ$ governed by an elliptic quasivariational inequality with unilateral constraints. The existence of optimal pairs of the problem is a well known result, see \cite{SS}, for instance. We associate to $\cQ$ a new optimal control problem $\wQ$, obtained by perturbing the state inequality (including the set of constraints and the nonlinear operator) and the cost functional, as well. Then, we provide sufficient conditions which guarantee the convergence of solutions of Problem $\wQ$ to a solution of Problem $\cQ$. The proofs are based on convergence results for elliptic quasivariational inequalities, obtained by using arguments of compactness, lower semicontinuity, monotonicity, penalty and various estimates. Finally, we illustrate the use of the abstract convergence results in the study of optimal control associated with two boundary value problems. The first one describes the equilibrium of an elastic body in frictional contact with an obstacle, the so-called foundation. The process is static and the contact is modeled with normal compliance and unilateral constraint, associated to a version of Coulomb's law of dry friction. The second one describes a stationary heat transfer problem with unilateral constraints. For the two problems we prove existence, uniqueness and convergence results together with the corresponding physical interpretation.
Nurturing life-science knowledge discovery: managing multi-organisation networks

Advancement of knowledge is the seed of the innovation process. As innovations have become more complex, organisations are driven by an increased need to collaborate in order to combine specialist capabilities to meet emerging market needs. The life sciences are one sector where collaborative innovation is highly evident. This article examines the phenomenon of knowledge-generating networks within the life sciences. The study explores the drivers of collaborative endeavours and investigates how knowledge networks linking the capabilities of public research centres and commercially focused pharmaceutical organisations can be managed to deliver the required synergistic benefits for partnering organisations. Three case studies of functioning university–industry knowledge networks are analysed and a model reflecting their network's life-cycle phases is presented. The discussion identifies the specific challenge posed at each of the network's development stages, together with the management process required to...
Numerical procedures for sample structures on stochastic differential equations

Procedures are discussed for the numerical construction of sample processes on stochastic differential equations. Structures of a relevant class of Gaussian white-noise functionals are analyzed to some closed forms, and new numerical algorithms for single noise problems are presented up to the accuracy of O(h3), or within errors of O(h7/2), in the sense of the mean-square norm.
The CIRCULAR model: advancing public health through citizen science initiated clinical and mechanistic research in atrial fibrillation

Citizen science is a transformative approach to advancing health research by bridging the gap between researchers and the public. The Dutch CIRCULAR model, which addresses atrial fibrillation (AF), the most common cardiac arrhythmia worldwide, offers a unique example of applying citizen science in biomedical and public health research. The project was established to systematically include people with AF and their families as partners in research, ensuring that their lived experiences inform priorities, study designs, and interventions. A central role is played by the online health community of the AFIP foundation, which engages the AF community through blog articles, forums, social media, and outreach campaigns. These activities stimulate dialogue, enhance health literacy, empower individuals to contribute hypotheses and solutions, and function as a marketing strategy to attract and retain diverse participants. By sharing outcomes through open-access formats and direct communication with participants, CIRCULAR creates a feedback loop between citizens and researchers that fuels new research directions in AF. Early activities have demonstrated the value of this approach. Patient-reported triggers and suppressors of AF episodes, including psychological stress and lifestyle factors, informed laboratory investigations and led to the co-design of clinical interventions such as dietary programs. These examples illustrate how co-creation can shape both preclinical and clinical research as well as citizen and student education. This review discusses how citizen science is conceptualized and implemented in the CIRCULAR model, presents ongoing and future activities, and reflects on the added value of patient involvement for public health and biomedical innovation. By embedding citizens throughout the research process, and actively engaging them through targeted outreach, CIRCULAR advances patient-centered innovation, strengthens empowerment and health literacy, and provides lessons for future participatory initiatives in complex chronic disease research.
Information Visualization of Assets under Management : A qualitative research study concerning decision support design for InfoVis dashboards in fund management

Information visualization dashboards are a widely used supportive tool in decision making. These tools can be difficult to create and utilize especially for the novice user. There is an extensive collection of company related data for decision making, resulting in a need of assistive tools. Prototypes were developed to research and identify design guidelines how to support fund managers in their decision making. This was carried out as a qualitative study involving 7 experts in fund management. The results provide insights and guidelines in decision supportive design for dashboards. The results indicate that there is a threshold in the number of displayed elements without limiting the cognitive analysis by the user. Three aspects; size, distribution and time should be included in the generating of suitable graphics. Assistive tools for connecting multiple context domains has been identified as a crucial element of decision support design. These guidelines should be investigated further in larger and more diverse studies in order to prove its full validity.
Marine Protected Areas: A Literature Review of Their Conservation Effectiveness in Safeguarding Marine Biodiversity

Marine Protected Areas (MPAs) are crucial for maintaining marine biological diversity because they safeguarded ecosystems, protected endangered or threatened species, and supported livelihoods, while social and economic security could be achieved by managing marine resources sustainably. This literature review aimed to synthesize related and relevant studies on the effectiveness of MPAs in safeguarding marine biodiversity. The study synthesized twenty (20) published peer-reviewed research articles and reports to scrutinize and provide answers to the questions surrounding the effectiveness, benefits, and challenges in enforcing this global conservation target. The outcomes of the reviewed and assessed papers revealed that well-managed MPAs significantly contributed to habitat restoration, species population recovery, and ecosystem resilience. However, issues such as weak enforcement, stakeholder conflicts, and climate change jeopardized their full potential. This review highlighted the contradictory position of this extensively used management tool at the intersection of biodiversity conservation and emphasized the necessity of adaptive management techniques to enhance MPA design, community involvement, and stronger policy enforcement.
Optimasi Query Pada Human Resource Information System (HRIS) di Universitas XYZ

Optimasi merupakan suatu langkah untuk mengoptimalkan waktu menjadi lebih efisien. Ketika sebuah query diberikan pada sistem database, optimasi penting dilakukan untuk memilih strategi yang efisien untuk mengevaluasi ekspresi relasi yang ditentukan. Query optimization adalah suatu proses untuk menganalisis query, menentukan sumber-sumber apa saja yang digunakan oleh query tersebut dan apakah penggunaan dari sumber tersebut dapat dikurangi tanpa merubah output. Kegiatan Pengelolaan manajemen sumber daya manusia yang baik sangat tergantung pada kualitas informasi untuk pengambilan keputusan dibidang sumber daya manusia. Kemampuan organisasi dalam memperoleh, menyimpan, memelihara dan menggunakan informasi sumber daya manusia merupakan faktor penting yang menunjang keberlangsungan hidup perusahaan. Perusahaan harus menyadari pentingnya pemenuhan kebutuhan sumber daya manusia secara berkualitas dan tepat sehingga perlu  untuk dikembangkan sistem informasi sumber daya manusia untuk menunjang pemenuhan sumber daya manusia yang berkualitas, Sistem ini yang namanya biasa disebut SISDM atau HRIS (Human Resources Information System). Hasil yang diperoleh dari pengujian sebelum optimasi dan sesudah dioptimasi menunjukan bahwa query yang sudah di optimasi waktu yang di butuhkan dalam melakukan pencarian data lebih cepat. Hasil percobaan pertama dengan 1000 data waktu yang dibutuhkan sebelum optimasi 0.023 dan sesudah di optimasi waktu yang didapatkan 0.015.
Tropical forests and biodiversity conservation: a new ecological imperative

Biodiversity, or biological diversity, is the number, variety and variability of living organisms. It is used today both as a loose description to embrace the richness and variation of the living world and politically within the context of economics and development for the purposes of national and international conventions and agreements. It has three related components at different levels of organization: genes, species and ecosystems. Genetic diversity is the basis of biodiversity and, although the possible combinations of gene sequences will probably exceed the total number of atoms in the universe, only a small fraction (<1%) of genetic material in higher organisms is outwardly expressed in the form and function of the organism (Thomas, 1992). Species diversity is commonly considered the measure of biodiversity: 1.7 million species have been described although estimates for the total number of extant species range from 5–40 million (even 100 million), mainly consisting of insects and microorganisms. However such estimates, and the numbers of species already identified, depend on how they were described as distinct by taxonomists and systematists — ecologically, morphologically, physiologically, genetically, mathematically? The need for commonly agreed names which define a distinct species is vital to conservation but much confusion and dissent can arise (see also Rojas, 1992).
Chirality driven topological electronic structure of DNA-like materials

Topological aspects of the geometry of DNA and similar chiral molecules have received a lot of attention, while the topology of their electronic structure is less explored. Previous experiments have revealed that DNA can efficiently filter spin-polarized electrons between metal contacts, a process called chiral-induced spin-selectivity (CISS). However, the underlying correlation between chiral structure and electronic spin remains elusive. In this work, we reveal an orbital texture in the band structure, a topological characteristic induced by the chirality. We find that this orbital texture enables the chiral molecule to polarize the quantum orbital. This orbital polarization effect (OPE) induces spin polarization assisted by the spin-orbit interaction from a metal contact and leads to magnetorestistance and chiral separation. The orbital angular momentum of photoelectrons also plays an essential role in related photoemission experiments. Beyond CISS, we predict that OPE can induce spin-selective phenomena even in achiral but inversion-breaking materials.
Citizen science for research in public health: perspective

In order to enhance health and lessen inequities, public engagement strategies that unite various stakeholders to jointly identify issues and develop alternatives are acknowledged as an essential tactic to support research-informed policy and implementation. Through the use of citizen science methods, researchers can collect and analyze more information and make research more cost-effective by enlisting members of the public as participants. Research on health has already been greatly impacted by the vast and unique data sets acquired through citizen science methodologies. Engaging community viewpoints into public health research and policy-making has proven difficult. Thus, research capacity must be developed to allow academics and policy-making and implementation stakeholders to meaningfully interact with the public. A fundamental tenet of public health is involving the community, which is seen as being vital in ensuring that initiatives and regulations designed for enhancing health and welfare that are pertinent to local needs and make the most from scarce resources.
Seizing the Means of Production: Exploring the Landscape of Crafting, Adapting and Navigating Generative AI Models in the Visual Arts

In this paper, we map out the landscape of options available to visual artists for creating personal artworks, including crafting, adapting and navigating deep generative models. Following that, we argue for revisiting model crafting, defined as the design and manipulation of generative models for creative goals, and motivate studying and designing for model crafting as a creative activity in its own right.
sj-docx-6-css-10.1177_24705470231169106 - Supplemental material for Mental Health Among People Presenting for Care of Physical Symptoms: The Factors Associated with Suicidality and Symptoms of Depression and Anxiety are Similar Across Specialties

Supplemental material, sj-docx-6-css-10.1177_24705470231169106 for Mental Health Among People Presenting for Care of Physical Symptoms: The Factors Associated with Suicidality and Symptoms of Depression and Anxiety are Similar Across Specialties by Sina Ramtin, Kathleen Carberry, Maria Correa, David Ring, Carol Alter and Donna Shanor in Chronic Stress
This was my DESTINY - Dynamics in blended electrode materials for Li-ion batteries: coupling electrochemistry and synchrotron based operando techniques, Dr. Dimitrios CHATZOGIANNAKIS

This PowerPoint presentation was presented by Dr. Dimitrios CHATZOGIANNAKIS during the webinar “This Was My Destiny”. The document provides an overview of his doctoral journey and a summary of his research project and academic work. It is part of the MSCA COFUND DESTINY programme (Grant Agreement No. 945357).
Vision-Language Modeling Meets Remote Sensing: Models, Datasets and Perspectives

Vision-language modeling (VLM) aims to bridge the information gap between images and natural language. Under the new paradigm of first pre-training on massive image-text pairs and then fine-tuning on task-specific data, VLM in the remote sensing domain has made significant progress. The resulting models benefit from the absorption of extensive general knowledge and demonstrate strong performance across a variety of remote sensing data analysis tasks. Moreover, they are capable of interacting with users in a conversational manner. In this paper, we aim to provide the remote sensing community with a timely and comprehensive review of the developments in VLM using the two-stage paradigm. Specifically, we first cover a taxonomy of VLM in remote sensing: contrastive learning, visual instruction tuning, and text-conditioned image generation. For each category, we detail the commonly used network architecture and pre-training objectives. Second, we conduct a thorough review of existing works, examining foundation models and task-specific adaptation methods in contrastive-based VLM, architectural upgrades, training strategies and model capabilities in instruction-based VLM, as well as generative foundation models with their representative downstream applications. Third, we summarize datasets used for VLM pre-training, fine-tuning, and evaluation, with an analysis of their construction methodologies (including image sources and caption generation) and key properties, such as scale and task adaptability. Finally, we conclude this survey with insights and discussions on future research directions: cross-modal representation alignment, vague requirement comprehension, explanation-driven model reliability, continually scalable model capabilities, and large-scale datasets featuring richer modalities and greater challenges.
The Relationship of Occupational Health and Safety K3 to Employee Performance in the Workplace Systematic Review Prospective cohort study

Occupational health and safety K3 ensures that people are not injured or become sick due to hazards in the workplace. ensuring that preventing the risk of frequent industrial accidents and diseases that cause the loss of workers' lives and or affect employee performance. K3 is a science that focuses on ensuring safety in the workplace. Occupational safety and health (K3) is defined as the science and application of technology regarding the prevention of work accidents and occupational diseases. By providing OSH protection, it is expected that workers can work safely, healthily and productively. Research purposes. To find out health and safety K3 on employee performance in the workplace. Method. Descriptive with observational cohort. Prospective. Results. Knowing the level of occupational health and safety K3 on employee performance at work. Conclusion. Therefore, it can be concluded that in occupational health and safety risks of OSH to improve the safety of health workers, which includes various occupational risk factors in the workplace, provide refresher training and routine induction training on OSH and use personal protective equipment (PPE). To ensure safety and health in the sector prioritizing the health of workers.