ethicalabs/Research-Intent-Collab huggingface dataset:
AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein sacsin reveals key residues for ATPase activity

Abstract                 The ataxia-linked protein sacsin has three regions of partial homology to Hsp90’s N-terminal ATP binding domain. Although a crystal structure for the Hsp90-like domain of sacsin has been reported the precise molecular interactions required for ATP-binding and hydrolysis are unclear. To better understand how sacsin may function as an ATPase we utilized an AlphaFold predicted structure of its Hsp90-like domain. Superimposition onto Hsp90, and other modelling approaches, have resulted in novel insights into sacsin’s structure. These encompass identification of residues within the sacsin Hsp90-like domains that are required for ATP binding and hydrolysis, including the catalytic arginine residues equivalent to that of the Hsp90 middle domain. Importantly, our analysis allows comparison of the Hsp90 middle domain with corresponding sacsin regions and has identified that sacsin has a shorter lid segment than the N-terminal domain of Hsp90. We also speculate, from a structural viewpoint, why ATP competitive inhibitors of Hsp90 do not appear to affect sacsin. Together our analysis supports the hypothesis that sacsin’s function is ATP-driven and would be consistent with it having a role as a molecular chaperone. We propose that the SR1 regions of sacsin be renamed as HSP-NRD (Hsp90 N-Terminal Repeat Domain; residues 84-324) and the fragment immediately after as HSP-MRD (Hsp90 Middle Repeat Domain; residues 325-518).
Competence of the President of the Republic of Poland to protect its sovereignty, independence and territorial integrity

The article is devoted to the study of the functions of the President of the Republic of Poland. It is stated that the protection of sovereignty, independence and territorial integrity is recognized by the Polish constitutional doctrine as one of the key functions of the President of the Republic of Poland as the head of state.It is emphasized that the competence of the President in the field of protection of sovereignty, independence and state integrity is determined by the type of republican form of government available in Poland and, in fact, includes «traditional» powersthat are inherent to the heads of all states, as well as powers that are unique to the Republic of Poland.The traditional powers of the President of the Republic of Poland as the head of state related to the protection of sovereignty, independence and state integrity include his powers related to the representation of the state and international relations, as well as the leadership of the Armed Forces and powers in the field of defense and internal security. It is noted that in the Republic of Poland, the effectiveness of the implementation of these directions is achieved with the help of the coordinated work of all state authorities, which is headed by the head of state. At the same time, it  is emphasized that given the fact that the sphere of protection of the sovereignty, independence and territorial integrity of the Polish state is the subject of both the Head of State and the Government, there is a need for a clear distribution of the powers of the specified subjects.It is summarized that the implementation by the President of the Republic of Poland of the function of protecting the sovereignty, independence and territorial integrity of the Polish state both in conditions of armed conflict and in peacetimedirectly imposes on the effectiveness of the system of state administration bodies, which represent the vertical of direct coercion: the army, the police and security services and simultaneous use of other constitutional and legal mechanisms of checks and balances.
A Study on Crowdsourcing for Multi-Label Affect Annotation [an abstract of dissertation and a summary of dissertation review]

(主査) 准教授 小山 聡, 教授 栗原 正仁, 教授 山本 雅人, 教授 小野 哲雄, 教授 川村 秀憲 情報科学研究科（複合情報学専攻）
Metagenomic Analysis of Soybean Rhizosphere Microbiome in Black Soil: Community Composition and Functional Insights

Summary statement                                        We performed metagenomic sequencing to analyze the microbial composition and functional profiles of the rhizosphere microbiome in the soybean cultivar                     Dongsheng                     7 grown in black soil at Meilisi, Northeast China. Furthermore, we constructed a microbial genome database and isolated endophytic bacteria from root nodules, providing support for further research and potential applications of the soybean‐rhizobia symbiotic nitrogen fixation system.
Developing resilience and cyber-physical protection capabilities for critical aviation infrastructures

Ο τομέας των Μεταφορών αποτελεί Κρίσιμη Υποδομή(ΚΥ) και βασικό πυλώνα της Οικονομίας, συνδέοντας ανθρώπους, κράτη, πολιτισμούς σε τοπικό και διεθνές επίπεδο. H δυσλειτουργία των υποδομών και των μέσων μεταφοράς επιφέρει σημαντικές αρνητικές επιπτώσεις στο κοινωνικοοικονομικό γίγνεσθαι, μέχρι ανθρώπινες απώλειες, επομένως οι ΚΥ των Μεταφορών πρέπει να προστατεύονται επαρκώς, τόσο από φυσικές απειλές, όσο και από απειλές του κυβερνοχώρου.Η διατριβή επικεντρώθηκε στον τομέα των Αερομεταφορών, ο οποίος αποτελεί το πιο διασυνδεδεμένο σύστημα ανταλλαγής πληροφοριών. Οι κυβερνοεπιθέσεις απειλούν τις ψηφιακές υποδομές της Αεροπλοΐας και μπορεί να επιφέρουν σοβαρό αντίκτυπο στην ασφάλεια των πτήσεων. Στον τομέα της διαχείρισης της εναέριας κυκλοφορίας, προτάθηκε ένα εκτεταμένο μοντέλο αντιμετώπισης των νέων απειλών, προτάθηκαν μέτρα ενίσχυσης της ανθεκτικότητας της Αεροπλοΐας από απειλές του κυβερνοχώρου και συγκροτήθηκε μια ολιστική στρατηγική άμυνας, πρόληψης και μετριασμού των απειλών αυτών. Περαιτέρω, διερευνήθηκε η ανθεκτικότητα των σύγχρονων αερολιμένων στον τομέα της κυβερνοασφάλειας, καθώς τα σύγχρονα αεροδρόμια αναβαθμίζουν τις υποδομές τους με την προσθήκη αυτοματοποιημένων διαδικασιών για τη καλύτερη εξυπηρέτηση των επιβατών. Παρουσιάστηκε μια ολοκληρωμένη ανάλυση σεναρίων κακόβουλων επιθέσεων σε σύγχρονα αεροδρόμια, για τον εντοπισμό απειλών, κινδύνων και την εφαρμογή βέλτιστων πρακτικών κυβερνοασφάλειας και ενίσχυσης της ανθεκτικότητας των υποδομών τους.Η έρευνα εστιάστηκε, επίσης, στον ταχύτερα αναπτυσσόμενο τομέα της Αεροπλοΐας, τα Συστήματα Μη Επανδρωμένων Αεροσκαφών (ΣΜΕΑ/UAS), τα οποία αυξάνονται σε τεχνική πολυπλοκότητα και πτητική αξιοπιστία, παρέχουν νέες επιχειρησιακές δυνατότητες και ταυτόχρονα θέτουν σημαντικές προκλήσεις κυβερνοασφάλειας. Αναλύθηκαν σενάρια επίθεσης σε κρίσιμες αεροπορικές υποδομές και προτάθηκαν τεχνικές λύσεις για την ενίσχυση της ανθεκτικότητας και την υπεράσπιση των αερολιμενικών υποδομών από επιθέσεις με UAS.Τέλος, αναπτύχθηκε μεθοδολογία και εργαλείο λογισμικού για την αξιολόγηση των αλληλεξαρτήσεων συμβάντων, που επιφέρουν καθυστερήσεις σε διασυνδεδεμένα αεροδρόμια. Το λογισμικό εντοπίζει τα κρισιμότερα αεροδρόμια. Διακρίνει, επίσης, τις δυσμενέστερες αλυσίδες αλληλεξαρτώμενων δρομολογίων, που θα πρέπει να αποφεύγονται από τους επιμελητές πτήσεων, για τον περιορισμό των επιπτώσεων των καθυστερήσεων στο αεροπορικό δίκτυο.
Diffusion of Cosmic Rays in a Multiphase Interstellar Medium Swept-Up by a Supernova Remnant Blast Wave

Supernova remnants (SNRs) are one of the most energetic astrophysical events and are thought to be the dominant source of Galactic cosmic rays (CRs). A recent report on observations from the Fermi satellite has shown a signature of pion decay in the gamma-ray spectra of SNRs. This provides strong evidence that high-energy protons are accelerated in SNRs. The actual gamma-ray emission from pion decay should depend on the diffusion of CRs in the interstellar medium. In order to quantitatively analyse the diffusion of high-energy CRs from acceleration sites, we have performed test particle numerical simulations of CR protons using a three-dimensional magnetohydrodynamics (MHD) simulation of an interstellar medium swept-up by a blast wave. We analyse the diffusion of CRs at a length scale of order a few pc in our simulated SNR, and find the diffusion of CRs is precisely described by a Bohm diffusion, which is required for efficient acceleration at least for particles with energies above 30 TeV for a realistic interstellar medium. Although we find the possibility of a superdiffusive process (travel distance proportional to t^0.75) in our simulations, its effect on CR diffusion at the length scale of the turbulence in the SNR is limited.
A scoping review on global climate change vulnerability, adaptation, and resiliency

Abstract Introduction: Climate change affects people, not only through environmental exposures and health outcomes, but how they live their lives. Consequences will affect various sectors, ranging from tourism to water to energy development—areas where people live, work, and enjoy.  Because of these forced changes, people must adapt. Methods: A scoping review was created to understand climate change vulnerability alongside adaption and resiliency measures that are being implemented in each continent of the world; this review is a subset of information from Zolnikov, T. R. (2019). Global Adaptation and Resilience to Climate Change.  In: T. R. Zolnikov (Ed.). Cham, Switzerland; Springer International Publishing.   Results: It was determined that adaptive capacity differs worldwide.  This is likely because the capacity to adapt and change is linked to both social and economic development; some regions in the world may not be sufficiently equipped and thus, may not be able to mitigate or adapt to changes. Such was the case in Australia, Europe, and North and South America, where economic resources were more available, and the general culture of climate change appeared to be more developed through various policies.  Whereas, for example, Asia and Africa were less economically developed and focused less on individual changes, but joined larger climate change agreements, such as the Kyoto Protocol. Conclusions: The objective of this review was to understand the differences that may help or hinder progress under the new world set forth by climate change. The information provided evidence that a “one size fits all” approach does not work to promote climate change resiliency.  In fact, each continent in the world suffers from some barriers to change, while also offering elements of success that can be shared. It is these types of lessons learned that can help pull the world together to learn from each other and promote the effectiveness of measures as well as the capacity for populations to adapt.  Keywords: Climate Change, Environmental Health, Global Health
Creating Probabilistic Forecasts from Arbitrary Deterministic Forecasts using Conditional Invertible Neural Networks

In various applications, probabilistic forecasts are required to quantify the inherent uncertainty associated with the forecast. However, numerous modern forecasting methods are still designed to create deterministic forecasts. Transforming these deterministic forecasts into probabilistic forecasts is often challenging and based on numerous assumptions that may not hold in real-world situations. Therefore, the present article proposes a novel approach for creating probabilistic forecasts from arbitrary deterministic forecasts. In order to implement this approach, we use a conditional Invertible Neural Network (cINN). More specifically, we apply a cINN to learn the underlying distribution of the data and then combine the uncertainty from this distribution with an arbitrary deterministic forecast to generate accurate probabilistic forecasts. Our approach enables the simple creation of probabilistic forecasts without complicated statistical loss functions or further assumptions. Besides showing the mathematical validity of our approach, we empirically show that our approach noticeably outperforms traditional methods for including uncertainty in deterministic forecasts and generally outperforms state-of-the-art probabilistic forecasting benchmarks.
Leveraging Smart Health Technologies in Critical Care Nursing to Enhance Palliative Care Quality for End-of-Life Patients

Background: In the intensive care unit (ICU), managing end-of-life (EOL) care is often hindered by delayed symptom recognition and communication gaps. Smart Health Technologies (SHT)—including AI-driven symptom monitors, wearable biosensors, and digital communication tools offer a specialized framework for nurses to transition from curative to palliative goals more effectively.Aim of the study: Evaluate the effect of integrating Smart Health Technologies on critical care nursing to enhance palliative care quality for end-of-life patients. Methods: A quasi-experimental, one-group pretest-posttest study was conducted. The sample consisted of 50 critical care nurses and 50 EOL patients was included using convenience sampling from intensive care units at Sohag university hospitals. Data were collected using the Demographic Data Sheet which divided to Part I: Nurses’ Demographic and Professional Data Sheet and Part II: Patients’ Clinical and Demographic Data Sheet, Palliative Care Quality Assessment Tool for patients, and the Nursing Competency in EOL Care Scale for nurses, administered before and after the technological intervention. Results:Post-intervention results showed a statistically significant improvement in care outcomes (p &lt; 0.001). Patients reported a 35% reduction in unmanaged pain scores and a significant increase in spiritual and emotional comfort due to proactive nursing interventions triggered by smart sensors.Nurses’ confidence in EOL care management increased by 42%. The use of AI-driven alerts significantly reduced the time-to-intervention for respiratory distress by an average of 15 minutes compared to pre-intervention manual monitoring. Families of the 50 patients reported higher satisfaction with the frequency and clarity of updates facilitated by the smart digital interface. Conclusion: The integration of Smart Health Technologies into critical care nursing significantly enhances the quality of life for EOL patients by enabling precise, proactive symptom management. For nurses, these technologies reduce the cognitive load and provide decision support that fosters more compassionate and timely palliative care. These findings suggest that SHT should be a standard component of ICU palliative protocols to ensure a dignified dying process.
Toward a general theory for the universality and scaling in critical thermal responses in biology

We developed a theory showing that under appropriate normalizations and rescalings, temperature response curves show a remarkably regular behavior and follow a general, universal law. The impressive universality of temperature response curves remained hidden due to various curve-fitting models not well-grounded in first principles. In addition, this framework has the potential to explain the origin of different scaling relationships in thermal performance in biology, from molecules to ecosystems. Here, we summarize the background, principles and assumptions, predictions, implications, and possible extensions of this theory.
4 Identify novel therapies for vascular disease and regenerative medicine based on the landmark discovery of induced pluripotent stem cells

Cardiovascular disease (CVD) is the leading cause of death globally, in 2013 it was responsible for 30% of all deaths worldwide. It has been shown that endothelial dysfunction is a major pathological mechanism that precedes CVD, yet these damaged endothelial cells (ECs) display poor regenerative capabilities. Current therapy is inadequate or unsuitable for a significant number of patients, however it is thought that the ability to replace damaged ECs could serve as a valuable therapeutic option for the future. Recent capability to generate induced pluripotent stem cells (iPSCs) from adult cells and differentiate these towards ECs holds great promise in the area of regenerative medicine. Nevertheless, the differentiation process involved is complex and not fully understood. An appreciation of a variety of molecular mechanisms is required in order to enhance protocols that could be replicated for novel therapies. This project has derived ECs from iPSCs using a reliable protocol. Results here confirmed successful differentiation with an up-regulation in important endothelial markers at the mRNA level alongside positive immunofluorescent staining. These differentiated cells were characteristically similar to mature ECs. In order to expose underlying mechanisms of EC differentiation, the novel gene SETSIP was shown to be upregulated during this process. Further investigation to stimulate differentiating cells with a SETSIP peptide noted an induction in endothelial markers. Finally, experiments involving epigenetic drugs induced changes in both endothelial marker and SETSIP expression. This project has elucidated the role of SETSIP and data shown here may be important in advancing therapeutic potential through the development of more robust protocols concerning EC differentiation.
The EU and The Human Right to Water and Sanitation: Normative Coherence as the Key to Transformative Development

The year 2015 is supposed to be a seminal moment in the international sustainable development agenda. World leaders are negotiating the Sustainable Development Goals Agenda and the European Union has declared 2015 to be the ‘European Year for Development’. The Post-2015 agenda is supposed to be characterized by more ‘transformative’ development strategies. Policy Coherence for Development (PCD) is considered to be an important tool for the establishment of ‘transformative’ development. This article examines EU development programmes in the field of water. It contends that even though the EU is a world leader in global water and sanitation programmes, its approach to development is not coherent with transformative change because these strategies employ PCD as a technical policy tool. Instead, the article contends that transformative development requires ‘normative coherence for development’ defined as coherence between strategies in development and non-development policy arenas and core democratic norms, such as human rights.
Experimental Results in Function Optimization with EDAs in Continuous Domain

This chapter shows experimental results of applying continuous Estimation of Distribution Algorithms to some well known optimization problems. For this UMDAc, MIMICc, EGNAbic, EGNABGe, EGNAee ,EMNAglobal, and EMNAa algorithms were implemented. Their performance was compared to such of Evolution Strategies (Schwefel, 1995). The optimization problems of choice were Summation cancellation, Griewangk, Sphere model, Rosenbrock generalized, and Ackley.
Site Reliability Engineering (SRE) in Geo-Diensten

Site Reliability Engineering (SRE) ist eine von Google entwickelte Methode, um die Stabilität einer Software zu messen und aufrecht zu erhalten, die gleichzeitig ein hohes Maß an Innovation ermöglicht. SRE wird auch von Google selbst für alle in Produktion befindlichen Systeme angewendet. SRE ist Google's Weg DevOps ('Software DEVelopment' + 'Information Technology OPerationS') zu leben. Es ist eine Methode Services messbar stabil zu halten und gleichzeitig Innovativ zu bleiben, aber auch Faktoren zu entdecken, die die Weiterentwicklung ausbremsen. Das Thema spricht Management, Administratoren und Entwickler gleichermaßen an und sort für ein gemeinsames Verständnis und gegenseitiges Agreement. In diesem Vortrag soll zunächst erklärt werden, was SRE ausmacht und wie es auf Geo-Daten-Infrastrukturen (GDIs) angewendet werden kann.
Climate Change Vulnerability and Disaster Risk Assessment Using Remote Sensing Technology and Adaptation Strategies for Resiliency and Disaster Risk Management in Selected Coastal Municipalities of Zambales, Philippines

The Philippines is one of the most hazard prone and vulnerable countries in the world to climate change effects due to its geographical location. Climate change is already happening and affecting many places causing huge problems to coastal ecosystems. Vulnerability and disaster assessment and mapping in coastal areas are essential tasks and undertakings for coastal disaster risk management. The objectives of this study were to assess the climate change vulnerability and disaster risks in the four municipalities (Sta. Cruz, Candelaria, Masinloc and Palauig) of Zambales and to determine the climate change community-based adaptation (CBA) and ecosystem-based adaptation (EBA) strategies. Remote sensing, GIS, secondary data gathering and key informant interview were used to assess vulnerability and disaster risks and mapping in the four municipalities. Survey questionnaire, focus group discussion and key informant interview were utilized in gathering data for the determination of climate change adaptation strategies. Using remote sensing technology, it was revealed that coastline changes have occurred in the shorelines of the four coastal municipalities after a decade. Sea level rise happened in Sta. Cruz and Masinloc, Zambales while there was build-up of soil in the coastline of Candelaria and Palauig, Zambales. Twelve hazard maps, 12 vulnerability maps and 12 disaster risk maps were generated for the three major disasters (flood, landslide, storm surge) in the four coastal municipalities. Based on the flood vulnerability and disaster risk assessment, the municipality of Palauig was found to be the most prone to flooding while the municipality of Candelaria was found to be the most vulnerable to landslide compared to other municipalities. All coastal barangays in the four municipalities were susceptible to storm surge. The four coastal municipalities were conducting community-based adaptation (CBA) and ecosystem-based adaptation (EBA) approaches in order to protect their coastal resources from the damaging impacts of climate change and improve the resilience of their local communities.
Automation system for neutron activation analysis at the reactor IBR-2, Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, Russia

The present status of development of software packages and equipment designed for automation of NAA at the reactor IBR-2 of FLNP, JINR, Dubna, RF, is described. The NAA database, construction of sample changers and software for automation of spectra measurement and calculation of concentrations are presented. Automation of QC procedures is integrated in the software developed. Details of the design are shown.
Beyond precautionary principle: policy-making under uncertainty and complexity

AbstractThe precautionary principle is a widely recognized approach in policy-making across various fields, emphasizing preventive action in situations of uncertain potential harm. However, its full potential remains unrealized due to implementation challenges. Our study analyzes policies related to face mask usage during the COVID-19 pandemic, characterized by significant uncertainty, time pressure, and potentially catastrophic consequences. We explore the challenges of balancing urgency against unforeseen negative consequences and determining the appropriate level of caution amid rapidly evolving scientific knowledge. To enhance the precautionary principle’s effectiveness, we argue for integrating additional principles: transparency, fairness, and adaptability. Transparency fosters public trust and informed decision-making through clear communication of policy rationales, uncertainties, and tradeoffs. Fairness ensures the equitable distribution of policy intervention benefits and burdens, considering vulnerable populations’ needs. Adaptability involves revising policies based on new information or changing circumstances, maintaining effectiveness and relevance. Our examination aims to provide insights and recommendations for improving the precautionary principle’s utility in policy-making, particularly where timely, informed action is crucial.