Premise: In Florence, where his family had to fight tooth and nail to hold on to their supremacy, Lorenzo  il Magnifico  de' Medici (1449 1492) found time to encourage the art of Perugino, Ghirlandaio, Botticelli, the young Leonardo, and tempestuous Michelangelo.

Hypothesis: His family gave in and lost their supremacy.
Relation: contradiction