Premise: The rule was reviewed by the FDA under the Order which requires Federal agencies to examine regulatory actions to determine if they have a significant impact on the States, on the relationship between the States and the Federal government, and on the distribution of power and responsibilities among the various levels of government.

Hypothesis: The FDA reviewed the rule to examine the actions involved and determine if it will have a significant impact on the relationship between States and Federal government. 
Relation: entailment