Question: I am using OpenGL to render a scene in python. My code works perfectly fine on windows but, for some reason, I'm having issues when importing opengl.gl on MacOS. The issue arises when calling from OpenGL.GL import ... in both python scripts and the python console. More specifically here is the exact call in my script: from OpenGL.GL import glGenBuffers, glBindBuffer, glBufferData, \ glGenVertexArrays, glBindVertexArray, glEnableVertexAttribArray, glVertexAttribPointer, \ glDrawArrays, glUseProgram, glEnable, glDisable, \ GL_ARRAY_BUFFER, GL_STATIC_DRAW, GL_DEPTH_TEST, \ GL_FLOAT, GL_FALSE, \ GL_TRIANGLES, GL_LINES, GL_LINE_STRIP  This results in the following error:  Traceback (most recent call last): File "/usr/local/lib/python3.8/site-packages/OpenGL/platform/darwin.py", line 35, in GL return ctypesloader.loadLibrary( File "/usr/local/lib/python3.8/site-packages/OpenGL/platform/ctypesloader.py", line 36, in loadLibrary return _loadLibraryWindows(dllType, name, mode) File "/usr/local/lib/python3.8/site-packages/OpenGL/platform/ctypesloader.py", line 89, in _loadLibraryWindows return dllType( name, mode ) File "/usr/local/Cellar/python@3.8/3.8.5/Frameworks/Python.framework/Versions/3.8/lib/python3.8/ctypes/__init__.py", line 373, in __init__ self._handle = _dlopen(self._name, mode) OSError: ('dlopen(OpenGL, 10): image not found', 'OpenGL', None) During handling of the above exception, another exception occurred: Traceback (most recent call last): File "/Users/iyadboustany/Desktop/lensmaster/Lensmaster.py", line 18, in <module> from MainWindow import MainWindow File "/Users/iyadboustany/Desktop/lensmaster/MainWindow.py", line 14, in <module> from Robot import Robot File "/Users/iyadboustany/Desktop/lensmaster/Robot.py", line 8, in <module> from Graphics.Scene import DHNode File "/Users/iyadboustany/Desktop/lensmaster/Graphics/Scene.py", line 13, in <module> from OpenGL.GL import glGenBuffers, glBindBuffer, glBufferData, \ File "/usr/local/lib/python3.8/site-packages/OpenGL/GL/__init__.py", line 3, in <module> from OpenGL import error as _error File "/usr/local/lib/python3.8/site-packages/OpenGL/error.py", line 12, in <module> from OpenGL import platform, _configflags File "/usr/local/lib/python3.8/site-packages/OpenGL/platform/__init__.py", line 36, in <module> _load() File "/usr/local/lib/python3.8/site-packages/OpenGL/platform/__init__.py", line 33, in _load plugin.install(globals()) File "/usr/local/lib/python3.8/site-packages/OpenGL/platform/baseplatform.py", line 97, in install namespace[ name ] = getattr(self,name,None) File "/usr/local/lib/python3.8/site-packages/OpenGL/platform/baseplatform.py", line 15, in __get__ value = self.fget( obj ) File "/usr/local/lib/python3.8/site-packages/OpenGL/platform/darwin.py", line 62, in GetCurrentContext return self.CGL.CGLGetCurrentContext File "/usr/local/lib/python3.8/site-packages/OpenGL/platform/baseplatform.py", line 15, in __get__ value = self.fget( obj ) File "/usr/local/lib/python3.8/site-packages/OpenGL/platform/darwin.py", line 45, in CGL def CGL(self): return self.GL File "/usr/local/lib/python3.8/site-packages/OpenGL/platform/baseplatform.py", line 15, in __get__ value = self.fget( obj ) File "/usr/local/lib/python3.8/site-packages/OpenGL/platform/darwin.py", line 41, in GL raise ImportError("Unable to load OpenGL library", *err.args) ImportError: ('Unable to load OpenGL library', 'dlopen(OpenGL, 10): image not found', 'OpenGL', None)  Notes:  Running glxgears works just fine. I'm running macOS Big Sur beta (20A5343i) I'm using python 3.8.5 I installed opengl using pip: pip3 install PyOpenGL PyOpenGL_accelerate 

Answer: This error is because Big Sur no longer has the OpenGL library nor other system libraries in standard locations in the file system and instead uses a cache. PyOpenGL uses ctypes to try to locate the OpenGL library and it fails to find it. Fixing ctypes in Python so that it will find the library is the subject of this pull request https://github.com/python/cpython/pull/21241 So a future version of Python should resolve the problem. To fix it now you can edit PyOpenGL file OpenGL/platform/ctypesloader.py changing line  fullName = util.find_library( name )  to  fullName = '/System/Library/Frameworks/OpenGL.framework/OpenGL'