Question: I am building an application with Djnago and MySql. I want to use docker for the deployment of my application. I have prepared a requirement.txt, docker-compose.yml and a Dockerfile docker-compose.yml version: "3" services: law-application: restart: always build: context: . ports: - "8000:8000" volumes: - ./app:/app command: > sh -c "python manage.py runserver 0.0.0.0:8000" depends_on: - mysql_db mysql_db: image: mysql:latest command: mysqld --default-authentication-plugin=mysql_native_password volumes: - "./mysql:/var/lib/mysql" ports: - "3306:3306" restart: always environment: - MYSQL_ROOT_PASSWORD=root - MYSQL_DATABASE=root - MYSQL_USER=root - MYSQL_PASSWORD=root  requirements.txt django>=2.1.3,<2.2.0 djangorestframework==3.11.0 mysqlclient==1.4.6  Dockerfile FROM python:3.7-alpine MAINTAINER Intersources Inc. ENV PYTHONUNBUFFERED 1 COPY ./requirements.txt /requirements.txt RUN pip install -r /requirements.txt RUN apt-get update RUN apt-get install python3-dev default-libmysqlclient-dev -y RUN mkdir /app WORKDIR /app COPY ./app /app RUN adduser -D jeet USER jeet  settings.py  DATABASES = { 'default': { 'ENGINE': 'django.db.backends.mysql', 'NAME': 'my-app-db', 'USER': 'root', 'PASSWORD': 'root', 'HOST': 'mysql_db', 'PORT': 3307, } }  I have been trying to run the command docker build . to build an image from docker file but I get this error. Looks like there is some issue with the MySql connector. I have tried searching for the solution but couldn't found any thing to fix this. I am able to build the image if I remove the mysql_db service from the docker-compose.yml. Sending build context to Docker daemon 444.7MB Step 1/12 : FROM python:3.7-alpine ---> 6c7f85a86cca Step 2/12 : MAINTAINER Intersources Inc. ---> Using cache ---> 03b6fa5764d4 Step 3/12 : ENV PYTHONUNBUFFERED 1 ---> Using cache ---> 22ecd91dcb55 Step 4/12 : COPY ./requirements.txt /requirements.txt ---> Using cache ---> e58c16108f20 Step 5/12 : RUN pip install -r /requirements.txt ---> Running in 8f3eb8240fce Collecting django<2.2.0,>=2.1.3 Downloading https://files.pythonhosted.org/packages/ff/82/55a696532518aa47666b45480b579a221638ab29d60d33ce71fcbd3cef9a/Django-2.1.15-py3-none-any.whl (7.3MB) Collecting djangorestframework==3.11.0 Downloading https://files.pythonhosted.org/packages/be/5b/9bbde4395a1074d528d6d9e0cc161d3b99bd9d0b2b558ca919ffaa2e0068/djangorestframework-3.11.0-py3-none-any.whl (911kB) Collecting mysqlclient==1.4.6 Downloading https://files.pythonhosted.org/packages/d0/97/7326248ac8d5049968bf4ec708a5d3d4806e412a42e74160d7f266a3e03a/mysqlclient-1.4.6.tar.gz (85kB) ERROR: Command errored out with exit status 1: command: /usr/local/bin/python -c 'import sys, setuptools, tokenize; sys.argv[0] = '"'"'/tmp/pip-install-e9kt1otq/mysqlclient/setup.py'"'"'; __file__='"'"'/tmp/pip-install-e9kt1otq/mysqlclient/setup.py'"'"';f=getattr(tokenize, '"'"'open'"'"', open)(__file__);code=f.read().replace('"'"'\r\n'"'"', '"'"'\n'"'"');f.close();exec(compile(code, __file__, '"'"'exec'"'"'))' egg_info --egg-base /tmp/pip-install-e9kt1otq/mysqlclient/pip-egg-info cwd: /tmp/pip-install-e9kt1otq/mysqlclient/ Complete output (12 lines): /bin/sh: mysql_config: not found /bin/sh: mariadb_config: not found /bin/sh: mysql_config: not found Traceback (most recent call last): File "<string>", line 1, in <module> File "/tmp/pip-install-e9kt1otq/mysqlclient/setup.py", line 16, in <module> metadata, options = get_config() File "/tmp/pip-install-e9kt1otq/mysqlclient/setup_posix.py", line 61, in get_config libs = mysql_config("libs") File "/tmp/pip-install-e9kt1otq/mysqlclient/setup_posix.py", line 29, in mysql_config raise EnvironmentError("%s not found" % (_mysql_config_path,)) OSError: mysql_config not found ---------------------------------------- ERROR: Command errored out with exit status 1: python setup.py egg_info Check the logs for full command output. The command '/bin/sh -c pip install -r /requirements.txt' returned a non-zero code: 1 

Answer: Just run pip install requirements after apt-get install because mysqlclient requires libmysqlclient-dev: You're using apt package manager with alpine base linux image which is incompatible. I recommend to take python3.7-slim with debian os which supports apt. FROM python:3.7-slim MAINTAINER Intersources Inc. ENV PYTHONUNBUFFERED 1 RUN apt-get update RUN apt-get install python3-dev default-libmysqlclient-dev gcc -y COPY ./requirements.txt /requirements.txt RUN pip install -r /requirements.txt RUN mkdir /app WORKDIR /app COPY ./app /app RUN adduser -D jeet USER jeet  If you do need alpine modify Dockerfile like this: FROM python:3.7-alpine MAINTAINER Intersources Inc. RUN apk update RUN apk add musl-dev mariadb-dev gcc RUN pip install mysqlclient RUN mkdir /app WORKDIR /app COPY ./app /app RUN adduser -D jeet USER jeet