## 2 Materials and Methods  
### Chemistry  
General. All anhydrous solvents, reagent grade solvents for chromatography and starting materials were purchased from either Aldrich Chemical Co. (Milwaukee, WI, USA) or Fisher Scientific (Suwanee, GA, USA) unless otherwise noted. Water was distilled and purified through a Milli-Q water system (Millipore Corp., Bedford, MA, USA). General methods of purification of compounds involved the use of silica cartridges purchased from Practicum, LLC. (www.practicum.com, last accessed on 23 September 2021) and/or recrystallization. The reactions were monitored by TLC on precoated Merck 60 F254 silica gel plates and visualized using UV light (254 nm). All compounds were analyzed for purity by HPLC and characterized by \({}^{1}\)H and \({}^{13}\)C NMR using a Bruker Ascend Avance III HD Spectrometer (500 MHz). Chemical shifts are reported in ppm (\(\delta\)) relative to the residual solvent peak in the corresponding spectra; chloroform \(\delta\) 7.27 and \(\delta\) 77.23, methanol \(\delta\) 3.31 and \(\delta\) 49.00 and coupling constants (\(J\)) are reported in hertz (Hz) (where, s = singlet, bs = broad singlet, d = doublet, dd = double doublet, bd = broad doublet, ddd = double doublet of doublet, t = triplet, tt = triple triplet, q = quartet, m = multiplet) and analyzed using MestreNova NMR data processing. \({}^{19}\)F NMR were run without a standard and are uncorrected. Mass spectra values are reported as m/z. Melting points were measured on a Buchi B-545 melting point instrument and are uncorrected, measured against benzoic acid 118.8-120.2 \({}^{\circ}\)C. Compounds 3, 6a-26a appear within US Provisional Patent Application No. 62/783,984. The quinazolines (5, 16-26) and amines (6-15) used in synthesis are all commercially available. LC-MS method: The liquid chromatography-mass spectrometry method was performed on an Agilent 1290 infinity coupled to Agilent 6538 Ultra High-Definition Quadrupole Time of Flight (UHD-QTOF) instrument. A separation was achieved by using reverse phase Waters Acuity UPLC HS T3 1.8 \(\upmu\)m (2.1 \(\times\) 100 mm) column from Waters (Milford, MA, USA). All solvents were purchased from Fischer Scientific LCMS Optima grade solvents. Water containing 0.1% formic acid was used as mobile phase A and acetonitrile containing 0.1% formic acid was used as mobile phase B. The injection volume was set at 1 \(\upmu\)L. Samples were injected in a gradient of 95% mobile phase A and 5% mobile phase B in the initial condition to 5% mobile phase A and 95% mobile phase B in 9 min. The eluent was held at that composition for an additional 3 min and switched back to the initial condition at 12 min. The MS data acquisition was performed from 50-1000 m/z at 1.0 spectra/sec scan rate. The source gas temperature was set at 350 \({}^{\circ}\)C with a flow of 81/min. The nebulizer gas was set at 55 psig. The capillary voltage was set at 3500 volts with fragmentor at 100, skimmer at 45 and octopole RF 500 volts. Prior to sample runs, the instrument was calibrated using Agilent low mass calibrant solution. Data analysis: The data collected in Agilent LC-MS was analyzed using Agilent Mass Hunter software for HRMS calculation. General Syntheses of N-Phenethylquinazolin-4-Amine Analogs  
General procedure A for base catalyzed S\({}_{\text{N}}\)Ar reaction for the preparation of compounds 6a, 7a, 9a, 12a-26a. In a sealed vial, 4-chloroquinazoline (5, 100 mg, 0.61 mmol, 1 equiv. ), 2-[4-(trifluoromethyloormethoxy)phenyl]ethylamine (7, 125 mg, 0.61 mmol, 1 equiv.) and potassium carbonate (84 mg, 0.61 mmol, 1 equiv. were combined in DMSO (4 mL). The reaction was heated to 100 \({}^{\circ}\)C for 12 h. The reaction mixture was concentrated to dryness. The residue was extracted with CH\({}_{2}\)Cl\({}_{2}\) and washed with 5% aqueous acetic acid solution (2x), water and brine. The organic phase was collected, dried over sodium sulfate, filtered, and concentrated in vacuo.