## 4 Synthesis/Applications of Organo-Fluorine Molecules  
Organofluorine compounds possess desirable physical properties that are utilized widely in pharmaceuticals, agrochemicals, polymers and as biomaterials. In the case of medicinal chemistry, fluorine functionalities including -R\({}_{\rm F}\), -F, -CF\({}_{3}\) -OCF\({}_{3}\) impart valuable _drug like_ physiological properties on molecules that improve receptor binding selectivity, increase lipophilicity and metabolic stability. The practical synthesis of organofluorine compounds is an important scientific endeavor. [PERSON] and coworkers contribution [13]: _Nucleic Acid Based Fluorinated Derivatives: New Tools for Biomedical Applications_, reviews recent developments in the preparation of nucleic acid-based fluorinated derivatives, e.g., nucleosides or oligonucleotides connected to fabricated by coupling highly fluorinated chains or labeled with either a nucleoside or an oligonucleotides-modified with one or more fluorine atoms, have been investigated recently due to their high potential for biomedical applications. The application of nucleoside-based fluorocarbon derivatives is focused on three broad objectives: (i) construction of novel supramolecular materials and/or devices; (ii) development of new drug delivery systems; and (iii) discovery of new therapeutic molecules. The authors' review recent research on highly fluorinated nucleic acids derivatives, in particular nucleoside and oligonucleotide fluorocarbon amphiphiles as well as those with properties and applications of fluorine-labeled fluorinated oligonucleotide analogues. The review succeeds in showcasing the future potential role that highly fluorinated amphiphiles could play in chemistry, biology and material science. _Synthesis of Some New Fluorinated Hexahydroquinoline and Acridinedione Derivatives in Trifluoroethanol_ is the article contribution by [PERSON], [PERSON] and [PERSON] [14] in which they describe a facile one-pot synthesis of new fluorinated hexahydroquinoline derivatives via an unsymmetric Hantzsch reaction utilizing 5-trifluoromethyl-1,3-cyclohexanedione, aldehydes, acetoacetate ester, and ammonium acetate in trifluoroethanol. The reaction is simple and rapid with high yield. The reaction was extended to the synthesis of hexahydroacridinedione under similar conditions. The biological activities of the products will be investigated. Understanding/predicting chemical reactions relies on the ability to calculate (simply) the energy and thermodynamics involved in the transformations. [PERSON] and [PERSON]'s contributed paper [15]: _Further Successes of the Meisenheimer Model_ illustrate that this concept is true. Their model involves calculating the energy of all possible Meisenheimer complexes at a standard level of _ab initio_ theory using the fluoride ion as a \"typical\" nucleophile, the preferred site for nucleophilicsubstitution then corresponds to the most stable (lowest energy) complex. This simple approach that predicted the principal site for 15 nucleophilic substitutions in aromatic perfluorocarbons has been extended and reliably tested by comparison to the series of recently published NH2 amination reactions of perfluoro-arenes in liquid ammonia by [PERSON] and coworkers. The model accurately predicted the experimental results for all of the SNAr reactions therefore confirming the model's general utility. The authors conclude with the prediction that their model predicts that mono-amination of 1-trifluoromethyl-2-amino 3,5,6-trifluorobenzene in liquid ammonia should produce almost exclusively 1-trifluoromethyl-2,6-diamino-3,5-difluorobenzene. [PERSON] [16] and coworkers present interesting organofluorine synthesis in their paper: _Novel Fluorinated Indanone, Tetralone and Naphthone Derivatives: Synthesis and Unique Structural Features._ They analyzed the uncommon product outcomes from the Claisen condensation coupled with the fluorinating reagent Selectfluor(r) with the above ketones.