# Effect of _Tinospora cordifolia_-Derived Phtocomponents on Cancer: A Systematic Review
## 3 Results
\begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**S. No.** & **Phytocomponents** & **Part in Use** & **Cancer Cell Lines** & \
\begin{tabular}{c} **Anticancer** \\ **Drug Used** \\ **with Tc** \\ \end{tabular} &
\begin{tabular}{c} **Effect on the Cancer** \\ **Cells** \\ \end{tabular} \\ \hline
7 & \begin{tabular}{c} N-formylannonin, \\ magnoflorine, \\ jatorrhizine \\ palmatine, \\ 11-hydroxymustakone, \\ corticoligoside A, \\ tinocordiside and \\ yangambin [9] \\ \end{tabular} & \
\begin{tabular}{c} Human cancer cell \\ lines, KB (human oral \\ squamous carcinoma), \\ Chromk-1 (hamster \\ ovary), HT-29 (human \\ colon cancer) and SiHa \\ (human cervical \\ cancer) and murine \\ primary cells \\ \end{tabular} &
\begin{tabular}{c} \\ **Effect on the Cancer** \\ **Cells** \\ \end{tabular} \\ \hline
8 & \begin{tabular}{c} Ethanol \\ phytofraction [10] \\ \end{tabular} & \begin{tabular}{c} Powdered \\ plant samples \\ hexane, \\ ethanol, and \\ water extract \\ \end{tabular} & \
\begin{tabular}{c} Human cancer cell \\ lines HeLa-B75, HL-60, \\ HEP-3B, PN-15, \\ and normal liver cell \\ lines \\ \end{tabular} &
\begin{tabular}{c} Cytotoxicity of cells \\ and induction of \\ apoptosis \\ \end{tabular} \\ \hline
9 & \begin{tabular}{c} Phytochemicals of \\ Ethanolic extract [11] \\ \end{tabular} & \begin{tabular}{c} Whole plant \\ and stem \\ ethanolic \\ extracts \\ \end{tabular} & \
\begin{tabular}{c} on human breast \\ cancer cells (MCF7 and \\ MDA MB 231) \\ \end{tabular} &
\begin{tabular}{c} Doxorubicin \\ cell cycle arrest in the \\ G2/M phase \\ \end{tabular} \\ \hline
11 & \begin{tabular}{c} Anthraquinones, \\ terpenoids, and \\ saponins and phenol \\ [12] \\ \end{tabular} & \begin{tabular}{c} Stem \\ solvents like \\ terpenoids, and \\ stem \\ chlorophyll, \\ ethyl acetate, \\ acetone, and \\ water extract \\ \end{tabular} & \begin{tabular}{c} mitomycin-C \\ (DU-145), \\ prostrate (IGROV-1), \\ ovary (IGROV-1), \\ and breast (MCF-7) \\ cell lines \\ \end{tabular} & \begin{tabular}{c} mitomycin-C \\ (DU-145), \\ paclitaxel \\ against breast \\ (MCF-7), and \\ adriamycin \\ (IGR-OV-1) \\ \end{tabular} & \begin{tabular}{c} \\ (DU-145), \\ paclitaxel \\ against breast \\ \\ \end{tabular} & \
\begin{tabular}{c} \\ (DSF7), and \\ adriamycin \\ (against ovary \\ (IGR-OV-1) \\ \end{tabular} &
\begin{tabular}{c} Cell growth inhibition \\ \end{tabular} \\ \hline
15 & \begin{tabular}{c} Pyrrole-based small \\ molecule [13] \\ \end{tabular} & \begin{tabular}{c} Leaves \\ ethyl acetate \\ and aqueous \\ extract \\ \end{tabular} & \
\begin{tabular}{c} MDA-MB-231 breast \\ cancer cells \\ \end{tabular} &
\begin{tabular}{c} Doxorubicin \\ \end{tabular} & Induction of apoptosis \\ \hline
17 & \begin{tabular}{c} Information was not \\ provided [14] \\ \end{tabular} & \begin{tabular}{c} Stem \\ alcohol extract \\ \end{tabular} & \
\begin{tabular}{c} human IMR-32 cell line \\ \end{tabular} & None &
\begin{tabular}{c} Upregulation of \\ senescence and \\ apoptosis \\ \end{tabular} \\ \hline
18 & \begin{tabular}{c} Phenolics contents \\ quercetin and trutin \\ [15] \\ \end{tabular} & \begin{tabular}{c} Stems \\ methanol \\ extract \\ \end{tabular} & \
\begin{tabular}{c} human breast cancer \\ MDA-MB-231 cells \\ \end{tabular} & None &
\begin{tabular}{c} Anti-proliferative \\ activity \\ \end{tabular} \\ \hline
19 & \begin{tabular}{c} Information was not \\ provided [16] \\ \end{tabular} & \begin{tabular}{c} ethanolic \\ extract \\ \end{tabular} & \
\begin{tabular}{c} Rat C6 glioma, US7 MG \\ human glioma, PC3 \\ prostate cancer cell \\ line, and HeLa cell line \\ \end{tabular} & None &
\begin{tabular}{c} Anti-proliferative, \\ anti-migratory/ \\ anti-metastatic \\ potential activity, and \\ induction of apoptosis. \\ \end{tabular} \\ \hline
20 & \begin{tabular}{c} Ready product from \\ standard ayurvedic \\ pharmacy [17] \\ \end{tabular} & \
\begin{tabular}{c} Information \\ was not \\ provided \\ \end{tabular} & KB cancer cell lines & Methotrexate &
\begin{tabular}{c} Cell cycle arrest at \\ G0/G1 phase \\ \end{tabular} \\ \hline \hline \end{tabular}
\end{table}