## 1 Introduction
In Figure 1, we show how these technologies participate in the supply chain; UAVs can perform in various processes. UAVs help to count products in the warehouse, to monitor work and are also used for the collection of products that must be returned to the production center. UAVs have a greater influence in the distribution due to their unique characteristics, which are delivering quickly, safely, and autonomously. Furthermore, these vehicles pollute less than trucks and represent a cost saving, therefore, service companies are considering them for their distribution to improve their service. Figure 1: Emerging technologies. throughout the supply chain. Source: based on [13]. UAVs provide preferable means to deliver packages in e-commerce businesses. These allow to quickly reach predefined and specific destinations without the need for great human support to improve the customer experience [14; 15]. UAV delivery is an innovative issue in the logistics environment because it is considered an alternative for package delivery companies, such as DHL, Amazon, SF Express, UPS, and Jingdong, which have used them to improve their services. Zipline, a company based in the United States, focuses on the creation of medical devices and has incorporated the use of UAVs, making it one of the most important companies in the world for the transport of medicines and blood products. In 2016, the company began transporting blood and platelets to the Kabgayi hospital in Rwanda; to date, they have delivered more than 2600 units of blood to 12 points in Rwanda health centers that perform more than 1400 flight appointments rosmearny. Another well-known case is Amazon, an American company dedicated to electronic commerce, which believes that using drones will allow savings in delivering services through its prototype Prime Air. The company's drones can fly up to 15 miles with a maximum speed of 50 miles per hour and carry packages weighing less than 2.27 kg. Amazon claims that 86% percent of their items can be delivered by drones [16]. Zookal is a company that rents out textbooks to students and links with the company Flirtey, to deliver packages directly to customers, where customers receive a phone to track the product through GPS and then receive the package in one place outdoors. As a result, there was the decrease in waiting times from two to three days to just two or three minutes [17]. Furthermore, another case is Dominos New Zealand that has made deliveries of pizza using an unmanned aircraft, which flies from 30 km per hour to 1.5 km per hour, increasing delivery speed and taking orders up to 2.5 kg [18]. In 2016, Czech online Mall operating in Poland, Slovakia, Hungary, Slovenia, and Croatia, reported the success of a pilot program using drones. The pilot program consisted of transporting the package at a distance of 2 km and was the first such operation in Central and Eastern Europe. [19]. The authors commented that the operation worked with the staff of the Center for Artificial Intelligence at the Faculty of Electrical Engineering of the Czech Technical University in Prague; the important thing to emphasize is that the drone can transport packages of units of up to 2 kg for a distance maximum of 60 km. The examples explained have something in common, because all the tests were carried out in countries where there are no regulations that prohibit the use of drones; in the case of Mexico, the agency responsible for the use of drones is the \"Direccion General de Aeronautica Civil\" (DGAC). Currently, the use of UAVs is included in the business models for e-commerce companies by including new modes of transport according to industry 4.0, considering that emerging innovations are focused on the last mile [20]. [PERSON] and others [21] consider that drones will be implemented within five to ten years in the distribution process, therefore, a mathematical model is proposed that plans an optimal distribution route between drones and trucks to create a better service delivery.