# New Local Drug Delivery with Antibiotic in the Nonsurgical Treatment of Periodontitis--Pilot Study
## 5 Discussion
\begin{table}
\begin{tabular}{c c c c c} \hline \hline
**Type of Bacteria** & **Stage II and III vs. IV** & **P** & **Grade B vs. C** & **P** \\ \hline \multirow{4}{*}{TBC before after} & 404,295,571 \(\pm\) 660,136,448 vs. & & **410,078,571 \(\pm\) 656,851,542 vs.** & \\  & 473,333,333 \(\pm\) 493,301,180 & 0.23 & **33,839,667 \(\pm\) 42,535,311** & **0.048** \\  & 386,071,429 \(\pm\) 595,735,933 vs. & 0.16 & 369,428,571 \(\pm\) 602,988,291 vs. & 0.74 \\  & 142,150,000 \(\pm\) 114,175,369 & & 180,983,333 \(\pm\) 102,863,996 & \\ \hline \multirow{2}{*}{Pg. before after} & 64,141 \(\pm\) 145,840 vs. 32,633 \(\pm\) 50,957 & 0.59 & 68,641 \(\pm\) 144,276 vs. 22,133 \(\pm\) 52,856 & 0.3 \\  & 73,439 \(\pm\) 230,011 vs. 289,500 \(\pm\) 417,614 & 0.59 & 79,653 \(\pm\) 229,047 vs. 275,000 \(\pm\) 427,446 & 0.71 \\ \hline \multirow{2}{*}{T.d. before after} & 5731 \(\pm\) 9219 vs. 5392 \(\pm\) 8920 & 0.9 & 7438 \(\pm\) 10,099 vs. 1408 \(\pm\) 2223 & 0.3 \\  & 40,956 \(\pm\) 74,652 vs. 23,850 \(\pm\) 35,928 & 0.48 & 41,263 \(\pm\) 74,510 vs. 23,133 \(\pm\) 36,272 & 0.54 \\ \hline \multirow{2}{*}{T.f. before after} & 32,595 \(\pm\) 90,773 vs. 9943 \(\pm\) 14,466 & 0.62 & 34,431 \(\pm\) 90,504 vs. 5660 \(\pm\) 8455 & 0.71 \\  & 11,238 \(\pm\) 21,684 vs. 14,867 \(\pm\) 25,083 & 0.77 & 11,224 \(\pm\) 21,730 vs.15,133 \(\pm\) 24,856 & 0.97 \\ \hline \multirow{2}{*}{A.a before after} & \multirow{2}{*}{Liczba wvkryc-3 vs. 2} & \multirow{2}{*}{Liczba wvkryc-3 vs. 2} & \multirow{2}{*}{} \\  & 1221 \(\pm\) 19,245 vs. 3578 \(\pm\) 5346 & 0.59 & 9264 \(\pm\) 19,221 vs. 3478 \(\pm\) 5442 & 0.97 \\  & 565 \(\pm\) 856 vs. 652 \(\pm\) 1405 & 0.65 & 457 \(\pm\) 873 vs. 903 \(\pm\) 1318 & 0.26 \\ \hline \multirow{2}{*}{P.i. before after} & 40,398 \(\pm\) 92,291 vs. 80,000 \(\pm\) 186,333 & 0.53 & 66,669 \(\pm\) 144,478 vs. 18,700 \(\pm\) 44,736 & 0.34 \\  & 148,125 \(\pm\) 44,800 vs. 26,667 \(\pm\) 65,320 & 0.2 & 158,075 \(\pm\) 423,223 vs. 3450 \(\pm\) 7209 & 0.33 \\ \hline \multirow{2}{*}{P.m. before after} & 2948 \(\pm\) 2751 vs. 7773 \(\pm\) 14,874 & 0.77 & 5547 \(\pm\) 9698 vs. 1708 \(\pm\) 1891 & 0.36 \\  & 695 \(\pm\) 676 vs. 412 \(\pm\) 702 & 0.2 & 544 \(\pm\) 564 vs. 765 \(\pm\) 937 & 0.77 \\ \hline \multirow{2}{*}{E.n. before after} & \multirow{2}{*}{Liczba wvkryc-2 vs. 0} & \multirow{2}{*}{} & \multirow{2}{*}{} \\  & 12,261 \(\pm\) 31,319 vs. 5580 \(\pm\) 7049 & 0.45 & 13,679 \(\pm\) 31,124 vs. 2272 \(\pm\) 3107 & 0.09 \\ \cline{1-1}  & 3264 \(\pm\) 2426 vs. 4867 \(\pm\) 6646 & 0.87 & 3336 \(\pm\) 2366 vs. 4698 \(\pm\) 6746 & 0.65 \\ \hline \hline \end{tabular}
\end{table} 
Table 3: Results of microbiological tests depending on the stadium and the degree of periodontitis. examination after 26 weeks. The fact that the study included smokers may constitute a disruptive factor [10]. The obtained reduction in the clinical parameters confirms the necessity of conducting nonsurgical treatment, especially in terms of reducing periodontal pocket depth and the location of connective tissue attachment, and confirms the gold-standard status of the scaling and root planning procedure in periodontal treatment [11; 12; 13]. Mechanical cleaning is necessary in order to improve clinical parameters, and the applied preparations can only support and consolidate the treatment results [14; 15]. With regard to the microbiological tests, there are currently no reports confirming effective reduction of periodontitis in periodontal pockets after local application of piperacillin in combination with taxobactam in patients with moderate and advanced periodontitis. No statistically significant differences between the studied groups were found in our own studies. After local application of Gelcide in combination with SRP, a significant increase in _Treponema danticola_ and decrease in _Micromonas micros_ as well as a considerably higher number of _Campocytophaga gingivalis_ were found in the microbiological test in relation to the control pockets.