## 2 Native Cyclodext
### Field Application of Cyclodext  
Cyclodext persist in captivating the interest of numerous researchers, attributable to their remarkable encapsulation capabilities and their multifaceted impacts as complex mediators and carters of various elements, rendering them exemplary contenders for both foundational and scientific claims across diverse industries. Consequently, cyclodext find extensive applications in various sectors, including but not limited to the medical, pharmaceutical, cosmetic, food, and textile industries, as well as in numerous processes pertinent to biotechnology, agriculture, and environmental science [12; 15; 19]. Within the realm of the food industry, cyclodext are employed as food additives for an array of purposes, including the enhancement of sensory attributes, the stabilization of flavourings agents, the extension of shelf life, and the sequestration of specific components [19; 24; 25]. Beyond food processing, cyclodext present additional technological benefits, such as the enhancement of nutritional attributes and the formulation of nutraceutical products. The \(\alpha\)-cyclodextrintrin complex may be utilized to maintain the crunchiness of certain products (e.g., cereals, snacks) post-storage and function as a soluble dietary fibre within beverages and foodstuffs [24; 25]. Modified cyclodextrin complexes are effective in preserving food quality, mitigating aroma loss, and inhibiting microbial proliferation, often being incorporated into plastic packaging films. Ultimately, cyclodext have been proven to excellently eliminate impurities from food products, which include insecticides, pheromones, fungicides, herbicides, growth regulators, and repellents [19; 24].  
Cyclodext assume a pivotal role in the cosmetics and personal care sectors, where they serve as stabilizing agents, enhancing the acceptability of odours and flavours, augmenting the efficacy of compounds by transforming liquid constituents into solid forms, reducing vapour pressure, modifying water solubility, and improving the thermal stability of essential oils [19; 24]. Given that cyclodext do not contribute to additional environmental pollution, they are utilized in the environmental sector for water treatment purposes, functioning as solubilizing agents for organic pollutants and facilitating the removal of both organic contaminants and heavy metals [24].  
Simultaneously, in the domain of analytical chemistry, cyclodext and their derivatives are employed in analytical separations, possessing the capability to differentiate between positional enantiomers, isomers, homologues, and functional groups. Furthermore, they are utilized as reagents in various methodologies, including UV-visible spectrophotometry, photoluminescence, and nuclear magnetic resonance [24]. Recently, cyclodext have been explored as catalysts for organic reactions, owing to their binding affinity with substrates and their ability to form inclusion complexes with small compounds [12; 19; 24].  
In pharmaceutical contexts, cyclodext are leveraged to facilitate the delivery of proteins, oligonucleotides, and oligosaccharides because of their ability to communicate across the cuticles of cells, thereby enhancing cellular uptake. They also serve to transport gene therapeutic agents, including viral vectors, plasmids, and antisense constructs, while concurrently protecting carbamates in vitro, thus prolonging their half-life [12; 19; 24; 26]. In accordance with the guidelines established by the Food and Drug Administration (FDA), the oral administration of native cyclodext is subject to no restrictions, as they are classified with \"Generally Recognized As Safe\" (GRAS) status, indicating their acknowledged safety for human consumption [26].