## 3 Results
\begin{table}
\begin{tabular}{c c} \hline \hline \multicolumn{2}{c}{**Non-Interventional Reviews**} \\ \hline
**Author** & **Result** \\ \hline [PERSON] et al. (2021) [PERSON] et al. (2021) [PERSON] et al. (2021) & An increase in bone sequestra, cortical bone lysis, and bone density was observed in bisphosphonate-related ONJ, while larger bone sequestra, more frequent periosteal reactions, and mandibular canal enhancement were noted in denosumab-related ONJ. \\ \hline [PERSON] et al. (2021a) [PERSON] et al. (2021a) [PERSON] et al. (2021) & The data reviewed have confirmed that an invasive procedure is the most common trigger of MRONJ with relatively high frequency of postoperative complications or recurrence following management. However, due to low-quality research available in the literature, it is difficult to ascertain quantitatively the susceptibility of immunosuppressivepressed patients in the development of MRONJ in non-oncology patients. \\ \hline [PERSON] et al. (2021b) [PERSON] et al. (2021) & Based on the limited data available in literature, it is plausible that not histologically analyzing all ONJ specimens could result in a small amount of undiagnosed and untreated malignant diseases (4.64\% based on large cohort studies). \\ \hline [PERSON] et al. (2021) [PERSON] et al. (2021) & Lack of evidence whether orthodontic treatment can precipitate MRONJ. Moreover, antireseptive drug therapy has been associated with a sub-optimal treatment outcome. The review reported adverse outcomes including: difficulty achieving root parallelism, difficulty achieving complete space closure, exaggerated mobility post-debond, increased duration of orthodontic treatment beyond expected completion, sclerotic alveolar bone changes seen on post-op radiographic images, an increased amount of root resorption and one case of ONJ. \\ \hline \multicolumn{2}{c}{**Interventional Reviews**} \\ \hline
**Author** & **Result** \\ \hline [PERSON] et al. (2017) [PERSON] et al. (2017) [PERSON] et al. (2017) [41] & Available evidence is insufficient to either claim or refute a benefit for hyperbaric oxygen therapy as an adjunct to conventional therapy. There is also insufficient evidence to draw conclusions about autofluorescence-guided versus tetracycline fluorescence-guided bone surgery. Moreover, there is insufficient evidence to conclude that the use of the other interventions investigated would reduce the risk of MRONJ or would improve healing of MRONJ. \\ \hline [PERSON] et al. (2018) [PERSON] et al. (2018) [45] & Patients with intraoral therapy appeared to have a better implant survival (5 implants failed out of 423) rate at 98.8\% vs. patients treated intravenously (6 implants failed out of 68) at 91\%. \\ \hline [PERSON] et al. (2020) [PERSON] et al. (2020) [46] & Laser ablation had a success of 60–95\% for complete healing. The controlled trials of leukocyte- and platelet-rich fibrin (LPRF) showed 60–100\% success for the same outcome. Fluorescence-guided surgery had a complete healing percentage of 85–90\%. \\ \hline Madrid \& [PERSON] (2009) Madrid \& [PERSON] (2009) [51] \\ \hline [PERSON] et al. (2020) [PERSON] et al. (2020) [55] & There is no evidence for using a drug holiday, but it is also clear that caused by a limited numbers of eligible patients, and a great variation in between these patients, high-level evidence for using an AR drug holiday is almost impossible to obtain this data. \\ \hline [PERSON] et al. (2016) [PERSON] et al. (2016) [58] & There is a lack of evidence from randomized controlled trials to guide treatment of bisphosphonate-related osteeonecrosis of the jaw (BRONJ). \\ \hline \multicolumn{2}{c}{The data reviewed confirmed that an invasive procedure is the most common trigger of MRONJ. The overall MRONJ disease recurrence was identified in \(n=6\) (16.6\%) cases. Two (\(n=2\)) recurrences were observed in the conservative treatment group, \(n=3\) recurrences were recognized in the conservative and antibiotics treatment group of patients and \(n=1\) was observed in the surgical treatment group. However, due to the low quality of available research in literature, it is difficult to draw a definitive conclusion on the validity of the presented treatment to manage patients affected by MRONJ associated with angiogenic therapy. \\ \hline \hline \end{tabular}
\end{table}