# Adipose Stem Cell Response to Borophosphate Bioactive Glass
## 5 Conclusions  
The development of bioactive glasses holds promise for a variety of applications in regenerative medicine, tissue engineering, drug delivery, and beyond. Bioactive glasses have already shown potential in the clinic for bone regeneration, wound healing, and dental applications due to their ability to stimulate tissue growth and integrate with surrounding tissues. One area of interest is developing bioactive glasses that can create or maintain pH-neutral environments. In addition to the clinical benefits of a pH-neutral biomaterial, this will allow the glasses to be in direct contact with cells in culture, increasing their use in 3D bioprinting, scaffold fabrication, and the creation of complex structures that mimic the properties of natural tissues, enhancing their integration and functionality in vivo. A pH-neutral bioactive glass will negate the often necessary pre-reaction required for alkaline and acidic glasses, making both cell culture and potential clinical use of bioactive glasses intricate. Overall, our study sheds light on the impact of bioactive glasses on ASCs' secretome, revealing alterations in the expression of several biomolecules. These findings have implications for designing biomaterials tailored to specific applications, as ASCs are found in several locations throughout the body. However, it is important to note limitations, such as the need to explore localized pH effects at the cell surface and further investigate how ion release influences cell function. As our understanding of bioactive glass interactions with cells and tissues advances, we can anticipate refinements in their formulation and design tailored glasses to specific clinical needs. This will allow their use for a wide range of medical conditions, including cardiovascular diseases, neurological disorders, and even cancer. Conceptualization, N.A.A., R.K.B. and J.A.S. ; methodology, N.A.A., B.A.B. and J.A.S. ; investigation, N.A.A., B.A.B., M.S.P. and R.L.B. ; writing--original draft preparation, N.A.A., R.K.B. and J.A.S. ; writing--review and editing, B.A.B., R.L.B., R.K.B. and J.A.S. ; supervision, J.A.S. All authors have read and agreed to the published version of the manuscript. This study received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. Not applicable. The datasets generated during the current study are available from the corresponding author with reasonable request. The authors declare no conflicts of interest. * [PERSON] et al. (2010) [PERSON]; [PERSON]; [PERSON] Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells. _Stem Cell Res. Ther._**2010**, \(1\), 19. [CrossRef]
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