## 2 Discussion
The combination of various membrane porins and antibiotics were studied in different studies, such as Ampicillin, Cephalexin, Cefurozime, Ceftaxime, Ceftzaidime, Ceftriaxone/HMP-PA [46], Omp-PD [46], Omp-SL [46], HMP-AB [46], Imipenem/CarO isoforms CarO1, CarO2, CarO3 [155; 156; 157], Imipenem, Meropenem, Colistin, Ceftzaidime, Ciprofloxacinacin/OrpD homolog [158], Imipenem, Meropenem, Ceftzaidime, Ampicillin, Fosfomycin/OccAB1-OccAB4 [159], Sulbactam, Tazobactam, Ticarcillin, Ampicillin, Piperacillin/DcaP [22], Ampicillin, Cephalexin, Ceftoxime, Ceftaxime, Ceftzaidime, Ceftriaxone/OmpA, and Omp-ECB [46], Meropenem/OmpF [55], Ampicillin, Benzylpenicillin/OmpF [26], Ciprofloxacinacin/OmpC [61] Sulbactam, Tazobactam, Avibactam/OmpF [40], OmpC [37], Imipenem, Meropenem/OmpC [77] Norfloxacin/OmpF [36], Enrofloxacin/OmpF [24; 81; 82; 83], Imipenem, Ceftazidime, Ceftzaidime, Ceftzaidime, Ciprofloxacinacin, Nozifloxacin, Nalidixic acid/OmpF [89; 90; 95], Carbenicillin, Ertapenem, Ampicillin/Ompf [100], Ampicillin, Amoxicillin, Carbonicillin, Azlocillin, Piperacillin/Ompf [44], Ceftepime, Ceftorazine, Ceftzaidime, Ceftoxin, Ampicillin/OmpF [101], Ceftorazine/OmpF [104], Ceftriaxone, Ceftrizadime, Ciprofloxacinacin, Eurofloxacin, Emrofloxacin/OmpF, OmpC [106], Piperacillin-Tazobactam/OmpF [107], Imipenem, Meropenem,/OmpF, OmpC [109], Benzylpenicillin, Ampicillin, Cefoxitin, Cefamandole, Ceftaxime, Ceftziadime, Ceftriaxone, Cephaloridine, Oxacillin, Ccephalothin, Cefpime, Imipenem, Ertapenem, Novobiocin, Erythromycin/OmpF, OmpC [112], Fosfomycin/OmpF [76], Ceftazidime, Ceftaxime/OmpF, OmpC [38], Ciprofloxacinacin/OmpF [48]. Kanamycin/OmpF, OmpC [75], Kanamycin, Norfloxacin, Ciprofloxacinacin/OmpF, OmpC [51], Norfloxacin/OmpF, OmpC [177], Norfloxacin, Ciprofloxacinacin, Enoxacin/OmpF [74], Norfloxacin/OmpF [52], Kanamycin, Gentamicin, Amikacin/Ompf, OmpC, LamB, ChiP [39], Gentamicin, kanamycin, Polymxin B/OmpF [53], Ceftazidime-Avibactam/Omp35, Omp36 [113], Imipenem, Meropenem/Omp35, Omp36 [114; 115], Ceftriaxone/Omp35, Omp36 [116], Ertenpenem, Cefpime/Omp36 [117], Imipenem, Ceftepime, Cefpime/Omp36 [118], Ampicillin, Ticarcillin, Piperacillin, Piperacillin, Ertenpemen, Imipenem, Meropenem, Certotazime, Ceftzaidime/Omp35, Omp36 [23], Norfloxacin/Omp36, Omp35 [17], Ampicillin, Ticarcillin, Piperacillin, Ertenpemen, Imipenem, Meropenem, Ceftoxime, Cefepime, Certazidine/OmpE36 and OmpE35 [23], Ceftazidime-Avibactam, Tigecycline, Colistin/OmpK36, OmpK35 [122], Ampicillin, Benzylpenicillin, Oxacillin, Cephaloridine, Cefoxitin, Cloxacillin, Cephalothin, Ceftriaxone, Ceftazidine, Erythromycin Imipenem, Ertenpenem, Cefepime, Novobiocin/OmpK35, OmpK36 [112; 113], Ampicillin, Ticarcillin, Piperacillin, Ertenpenem, Imipenem, Meropenem, Ceftoxime, Ceftazidine/OmpK36, OmpK35 [23], Ertenpem, Ceftorazine, Ceftzaidime/OmpPstl [121], Fosfomycin/OprO, Oppr [165], Meropenem, imipenem/OprD [140; 143] Ceftazidime-Avibactam, Ceftolozane-Tazobactam/OprD [144], Imipenem, Meropenem/OccD3 [42], Temocillin/OccK1, OccK2 [135], Fosmidomycin/OprO, OrPP [123], ceftazidime, cefotaxime, carbenicillin/Occk8(OprE) [164]. Note that the list is not limited to the mentioned names. These findings indicate that outer membrane porins can have an impending responsibility towards the efficacy of antimicrobials/antibiotics and may serve as potential targets to support the progression of innovative and novel antimicrobial approaches [6; 31; 35; 180]. As per the studies, transmembrane proteins present in the outer membrane of the Gram-negative bacterium might be directly responsible for the transport of small molecules such as nutrients and antibiotics [6; 35; 180]. The porin channels are selective for specific types of molecules, and their size and charge selectivity determine the types of molecules that can cross the outer membrane [35; 180].