# Facial Anti-Aging Treatments with Soft Peeling and Microneedling Technique
## 3 Results  
The study recruited 56 subjects between the ages of 42 and 73 (average 56.18). Of these subjects, 38 women and 11 men completed the study and were evaluated at 30 and 60 days after treatment, while 4 subjects who did not perform the check within the pre-established timing and 3 subjects who experienced the onset of an acute inflammatory pathology that led to the intake of medication, were not considered suitable for evaluation. The evaluations showed a significant improvement in wrinkles in all areas of the face (Table 2). There were no significant differences in the different subpopulations compared: males-females, Glogau 3-Glogau 4, smokers-non smokers, phototypes 1-4, or subjects who had their check up at 30 days-control group who had their check up at 60 days. The wrinkles that benefited most from the treatment were those originating from the modification of the dermis and the dermal-epidermal junction, such as cheek and periauricular wrinkles, and those due to the structural modification of the subcutaneous loose connective tissue with the interaction of gravity, such as the lines of the corners of the mouth and the nasolabial folds (Scheme 1). The wrinkles that benefited the least were those induced by mimic muscles, such as forehead wrinkles, barcode wrinkles, and glabellar wrinkles (Figures 1-4 and Scheme 1). \begin{table}
\begin{tabular}{c c c c c c} \hline \hline \multirow{2}{*}{**Facial Wrinkle**} & \multirow{2}{*}{**Pre-Treatment**} & **30 Days** & **60 Days** & **Grade of** & **Grade of** \\  & & **Post-Treatment** & **Post-Treatment** & **Improvement (1)** & **Improvement** \\ \hline Horizontal forehead lines & 3.938 \(\pm\) 0.77 & 3.367 \(\pm\) 0.67 & 3.388 \(\pm\) 0.68 & 0.571 & 0.551 \\ Glabellar frown lines & 3.857 \(\pm\) 0.84 & 3.082 \(\pm\) 0.73 & 3.122 \(\pm\) 0.70 & 0.776 & 0.735 \\ Periorbital lines & 3.755 \(\pm\) 0.83 & 2.775 \(\pm\) 0.55 & 2.775 \(\pm\) 0.55 & 0.975 & 0.989 \\ Preauricular lines & 3.367 \(\pm\) 0.73 & 2.286 \(\pm\) 0.74 & 2.265 \(\pm\) 0.73 & 1.082 & 1.102 \\ Cheek lines & 3.857 \(\pm\) 0.70 & 2.714 \(\pm\) 0.89 & 2.735 \(\pm\) 0.91 & 1.143 & 1.123 \\ Nasolabals fold & 3.612 \(\pm\) 1.02 & 2.755 \(\pm\) 0.85 & 2.775 \(\pm\) 0.87 & 0.857 & 0.837 \\ Radial upper lip lines & 4.081 \(\pm\) 1.04 & 3.429 \(\pm\) 0.84 & 3.449 \(\pm\) 0.84 & 0.653 & 0.632 \\ Radial lower lip lines & 3.142 \(\pm\) 1.02 & 2.306 \(\pm\) 0.87 & 2.306 \(\pm\) 0.87 & 0.836 & 0.836 \\ Corner of the mouth lines & 3.694 \(\pm\) 1.12 & 2.775 \(\pm\) 0.92 & 2.734 \(\pm\) 0.93 & 0.919 & 0.959 \\ Marionette lines & 4.143 \(\pm\) 0.93 & 3.347 \(\pm\) 0.85 & 3.347 \(\pm\) 0.88 & 0.796 & 0.795 \\ Labiomental crease & 3.449 \(\pm\) 0.89 & 2.612 \(\pm\) 0.70 & 2.632 \(\pm\) 0.72 & 0.837 & 0.816 \\ \hline \hline \end{tabular}
\end{table} 
Table 2: Comparison between the average values resulting from the medical evaluation (carried out according to the Lamperle rating scale, Table 1) before treatment, at 30 days post-treatment and at 60 days post-treatment. The last 2 columns show the values of the degree of improvement after 30 days (1) and after 60 days (2). **Figure 1.** Female patient, Glogau 3, phototype 3, 42 years old. The treatment showed an improvement of 2 points on the corner of the mouth line (arrow) and 1 point on the nasolabial fold (blue circle). Even though it was not evaluated in this study, the treatment brought benefits in subjects with active acne, as in this case. Figure 3: Female patient, Glogau 3, phototype 2, 64 years old, in whom superficial wrinkles predominate as signs of advanced aging. The cheek lines improved by 1 point (blue circle). Figure 2: Female patient, Glogau 3, phototype 2, 51 years old, with many expression lines (also present at rest), and dyschromia. The improvement of periocular wrinkles of 1 point (arrows) was associated with the improvement of hyperchromic spots, another typical sign of advanced facial aging (blue circle).