## 2 Materials and Methods
### Data--Representative Sample and Measurement Units
\begin{table}
\begin{tabular}{c c c c c c} \hline \hline  & \multicolumn{4}{c}{**(a)**} \\ \hline  & **N** & **Mean** & **Sd** & **Min** & **Max** \\ \hline SN & 18 & 75.83333 & 1.158697 & 73.84 & 78.22 \\ PTM-N & 18 & 51.36722 & 2.375254 & 47.15 & 53.94 \\ AR-PTM & 18 & 39.80333 & 3.095097 & 31.77 & 43.31 \\ SAr & 18 & 36.40722 & 2.750743 & 30.76 & 39.71 \\ NSAr & 18 & 118.1539 & 5.262845 & 109.65 & 126.52 \\ NSBa & 18 & 127.9272 & 4.531925 & 120.73 & 133.84 \\ N-A-PG & 18 & 6.463333 & 1.5576 & 4.43 & 9.22 \\ ANS-N & 18 & 53.02833 & 4.486369 & 48.92 & 60.81 \\ ANS-Me & 18 & 58.04833 & 4.10118 & 55.18 & 68.02 \\ N-Me & 18 & 111.4622 & 7.348106 & 105.02 & 128.83 \\ S-Go & 18 & 71.94833 & 8.449223 & 65.23 & 85.98 \\ SN-MP & 18 & 34.42056 & 1.398527 & 33.12 & 39.15 \\ FH-MP & 18 & 25.56389 & 2.428631 & 23.28 & 31.54 \\ Co-A & 18 & 89.36333 & 2.57655 & 85.26 & 92.47 \\ ANPog & 18 & 3.172778 & 3.092271 & \(-8.65\) & 5.72 \\ SNA & 18 & 83.85167 & 1.831523 & 78.95 & 86.52 \\ SNB & 18 & 80.11778 & 1.816926 & 75.79 & 82.42 \\ ANB & 18 & 3.730556 & 0.7057868 & 2.89 & 5.74 \\ SArGo & 18 & 146.2617 & 6.500576 & 137.51 & 159.19 \\ U1-L1 & 18 & 138.9233 & 4.288158 & 129.27 & 147.82 \\ ANS-PNS & 18 & 55.48167 & 2.146248 & 53.52 & 58.91 \\ Ar-Go & 18 & 39.53444 & 4.258378 & 35.89 & 49.15 \\ Go-Pog & 18 & 80.60833 & 3.458699 & 74.18 & 87.52 \\ Co-Gn & 18 & 111.2456 & 5.011898 & 106.14 & 118.97 \\ B-Pog & 18 & 7.232778 & 1.473267 & 4.67 & 9.75 \\ ArGoGn & 18 & 124.6311 & 2.364735 & 121.95 & 132.26 \\ \hline \hline \multicolumn{4}{c}{**(b)**} \\ \hline  & **N** & **Mean** & **Sd** & **Min** & **Max** \\ \hline SN & 18 & 70.19833 & 3.893115 & 63.23 & 77.32 \\ PTM-N & 18 & 52.11556 & 1.050738 & 50.28 & 53.46 \\ AR-PTM & 18 & 37.20333 & 0.8617149 & 35.9 & 38.45 \\ SAr & 18 & 33.22944 & 1.340042 & 31.25 & 36.04 \\ NSAr & 18 & 123.0789 & 0.5853593 & 122.25 & 123.93 \\ NSBa & 18 & 130.6839 & 1.605671 & 128.12 & 133.56 \\ N-A-PG & 18 & 5.203333 & 1.134165 & 3.53 & 7.23 \\ ANS-N & 18 & 54.25111 & 1.308829 & 52.54 & 56.35 \\ ANS-Me & 18 & 61.36778 & 1.744421 & 58.01 & 64.21 \\ N-Me & 18 & 115.5078 & 3.07832 & 110.86 & 120.56 \\ S-Go & 18 & 73.60722 & 6.495733 & 65.02 & 83.98 \\ SN-MP & 18 & 33.96944 & 1.104602 & 32.12 & 35.67 \\ FH-MP & 18 & 28.79222 & 0.7744261 & 27.45 & 30.56 \\ Co-A & 18 & 86.21722 & 1.84672 & 83.52 & 88.9 \\ ANPog & 18 & 2.386667 & 1.388444 &.34 & 4.24 \\ SNA & 18 & 81.83611 & 0.6042703 & 81.12 & 82.85 \\ SNB & 18 & 79.16556 & 1.225226 & 77.23 & 81.09 \\ \hline \hline \end{tabular}
\end{table} 
Table 1: (**a**) Summary statistics for the first sample comprising 18 Prader-Willi patients, (**b**) summary statistics for the control sample (18 subjects without the disease). \begin{table}
\begin{tabular}{c c c c c c} \hline \hline  & \multicolumn{4}{c}{**(b)**} \\ \hline  & **N** & **Mean** & **Sd** & **Min** & **Max** \\ \hline ANB & 18 & 2.637222 & 0.7130614 & 1.56 & 3.89 \\ SarGo & 18 & 142.9033 & 2.160136 & 139.41 & 145.89 \\ U1-L1 & 18 & 126.3667 & 2.913298 & 122.85 & 130.56 \\ ANS-PNS & 18 & 55.21111 & 2.278048 & 52.24 & 59.11 \\ Ar-Go & 18 & 44.18667 & 3.546436 & 39.56 & 49.96 \\ Go-Pog & 18 & 82.20111 & 2.778252 & 79.12 & 87.23 \\ Co-Gn & 18 & 112.6739 & 4.123416 & 107.36 & 119.56 \\ B-Pog & 18 & 8.666111 & 0.4311973 & 7.93 & 9.35 \\ ArGoGn & 18 & 127.1172 & 4.059518 & 121.36 & 132.87 \\ \hline \(N\) & 18 & & & \\ \hline \end{tabular} Source: Authors’ contribution in Stata 16.  
\end{table} 
Table 1: _Cont._  
Figure 1: Sample representation by sex: (**a**) Prader–Willi sample; (**b**) control sample. Source: authors’ contribution in R version 3.6.3. Figure 2: Sample reprezentation by age: (**a**) Prader–Willi sample; (**b**) control sample. Source: authors’ contribution in R version 3.6.3.