The construction industry in Malaysia has adopted the Green Building Index (GBI) as the ratings tool for the environmental performance of any building. The reason is that the structural design of any project is influenced mainly by the appropriate selection of materials [4; 5]. Similarly, the structural design concept also affects the speed and quality of construction. Sometimes, inefficient structural concepts may cause the consumption of high material volume, because it is either over-designed, or unnecessarily high factor of safety is imposed on the design [4]. In order to achieve the target, the green building system is one of the most effective methods that considers all three criteria for promoting sustainable development [15]. The eco-efficiency measurement is considered a useful means for assessing the sustainability of a project, because it links together economic activities and the ecosystem impacts. Usually, eco-efficiency dictates the concept of developing or building a project with the aid of an optimum amount of resources, compared to that utilized in traditional projects. It also aims to generate less waste and pollution. In general, the principal concept for designing green buildings is the achievement of environmental friendliness [16]. In several countries, various standards are implemented for the assessment of buildings. In China, the standard called Evaluation Standard Green Building (ESGB) is practiced, whereas Leadership in Environmental and Energy Design (LEED) is a recommended method in the United States. Similarly, the Building Research Establishment's Environmental Assessment Method (BREEAM) is implemented in the United Kingdom, Australian practitioners use the Green Star system, and the Green Building Index (GBI) is adopted in Malaysia. The concept of sustainable design has a lot of potential for benefiting the environment, economy, and the social community. For example, for comfortable living, it is essential to minimize and reduce the current level of carbon emissions, which is only possible by implementing the rules of sustainable development. Furthermore, sustainable development emphasizes creating an equilibrium between the economic, environmental, and social costs of a project. The development of eco-efficient self-compacting concrete with marble sludge have been done, and it shows that changing the M/C ratio affects the compressive strength around 15%, and it shows the W/C has a greater effect than the M/C ratio on the compressive strength [17]. Design of Experiments (DOE) Made Easy, is a statistical software that offers a wide selection of graphs, including 3D graph, predicted vs. actual graph and contour graph which can help to better explain the data [18]. It is necessary to introduce new concepts and approaches in the building design processes that can fulfill the criteria of sustainable development and facilitate the objectives of the green buildings, in compliance with the relevant standards. Malaysia is a tropical country, and more than 70% of the Malaysian population lives in a single or double story house. Almost 100% of houses are made reinforced concrete (RC) structure. Therefore, this research was aimed at assessing the environmental, economic, and social impacts of the typical design, and developing an approach for enhancing the eco-efficiency.