## Appendix A Automated Accuracy Evaluation Results
Larger-scale randomized controlled trials of longer duration in selected age groups are needed. * **System Generated Text:** The benefits of Vitamin B are potentially lowering homocysteine levels, which might reduce the risk of cognitive decline and dementia. The benefits of polyunsaturated fatty acids are that they can enhance cognitive functions and may counteract the negative effects of poor dietary habits. The benefits of combination therapies are potential synergistic benefits in cognitive function from combinations like estrogen, statins, and polyunsaturated fatty acids. While the benefits are promising, the studies often call for more research to fully understand the effectiveness and safety of long-term supplementation. Dosage and the specific combinations of supplements need to be carefully considered to avoid potential adverse effects. Individuals, particularly those at risk of cognitive decline or with existing mild cognitive impairment, might consider discussing with healthcare providers the possibility of incorporating certain supplements into their regimen. However, it is crucial to do so under professional guidance to tailor the supplement type and dosage to individual health needs and conditions. **Question 5:**  
* **Question Text:** Does ginger supplementation lower blood pressure? * **Reference Text:** Pooled analysis suggested that ginger supplementation can reduced systolic blood pressure and diastolic blood pressure. When studies were categorized based on participants' mean age, ginger dosage and duration of intervention, systolic blood pressure and diastolic blood pressure were significantly decreased only in the subset of studies with mean age less than or equal to 50 years, follow-up duration of less than or equal to 8 weeks and ginger doses greater than or equal to 3 g per day. Our findings revealed that ginger supplementation has favorable effects on blood pressure. Nonetheless, further studies are warranted before definitive conclusions may be reached. * **System Generated Text:** In conclusion, while there is some evidence supporting the potential of ginger to aid in blood pressure management, particularly through its vasodilatory properties and possible synergistic effects with anti-hypertensive medications, the evidence is not uniformly strong or conclusive. Further research, particularly large-scale human clinical trials, is needed to better understand the role of ginger in blood pressure regulation and its long-term health impacts. **Question 6:**  
* **Question Text:** Can improved legume varieties optimize iron status in low- and middle-income countries? * **Reference Text:** Evidence shows that, in addition to depletion of biomarkers of iron status, consumption of improved legumes is associated with both clinical and functional outcomes. The prevalence of iron deficiency decreases with consumption of improved legumes, with increases of less than or equal to 3.0 g/L in Hb concentrations. Improvement in cognition and brain function in women has been reported as well. However, further research is necessary in more at-risk groups and also to show if the reported improvements in status markers translate to improved health outcomes. Evidence from the included studies shows potential from consumption of improved legumes suggesting them to be a sustainable solution to improve iron status. * **System Generated Text:** Improved varieties of legumes that incorporate higher levels of bioavailable iron and lower inhibitors like phytic acid and polyphenols can significantly contribute to better iron status, particularly in regions where legumes are a dietary staple. Biofortification appears to be a sustainable and effective strategy to combat iron deficiency in low- and middle-income countries, potentially reducing the global disease burden associated with micronutrient deficiencies. While the current evidence is promising, ongoing research and careful implementation are necessary to optimize the benefits of biofortified legumes and ensure they reach the populations most in need.