# Quantification of Liver Fibrosis--A Comparative Study
## 4 Results and Discussion  
In this section, a summary is made of how the examined from the literature methods were able to quantitate hepatic fibrosis in microscopic images, obtained from patients with chronic liver conditions. During the PRISMA selection method, when the gathered papers were sorted by methodological approach, a corresponding number of groups were formed in the following tables (Tables 2-5) to summarize all results after the end of the discussion. \begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Author/Year** & **Dataset/Histological Stain** & **HAI** & **Image Analysis Method** & **Results/Remarks** \\ \hline \multirow{4}{*}{[PERSON] et al. 1985 [11]} & 38 samples (8 steatosis w/o & & & & \\  & fibrosis, & Schraculberis, 7 & & & & Histomorphemetric–colormimetric \\  & fibrotic, 15 alcoholic & - & - & - & CPA correlation (\(r=0.77\), \\  & climatic patients) & & & \(p<0.001\)) \\  & Stains: RifE, Karl system & & & & \\ \hline \multirow{4}{*}{[PERSON] et al. 1993 [12]} & 59 samples (54 HCV & & & \\  & antibody patients) & & & Histomorphemetric analysis (Biocom 200) & Histomorphemetric–colormimetric \\  & Stains: [PERSON]’s silver, & & & & \\  & Stinis Past real & & & & \\ \hline \multirow{4}{*}{[PERSON] et al. 1993 [13]} & 24 samples (autopsy, hepatic & & & \\  & transmission patients) & & & & \\  & Stains: Sririva red, Fast green, & & & & \\  & Azan, [PERSON] & & & & \\ \hline \multirow{4}{*}{[PERSON] et al. 1994 [14]} & 20 samples (alcoholic & & & \\  & viral patients) & & & & \\  & Stain: picro-Sirus red & & & & \\ \hline \multirow{4}{*}{[PERSON] et al. 1996 [15]} & 65 samples (liver & & & \\  & disease patients) & & & & \\  & 5 normal as controls & (modified) & & & \\  & & & & & \\ \hline \multirow{4}{*}{[PERSON] et al. 1997 [16]} & 45 samples (25 CHC patients. 20 & & & \\  & CH patients as controls & & & & \\  & Stains: H&H, Azan & & & \\ \hline \multirow{4}{*}{[PERSON] et al. 1988 [17]} & 243 samples (83 viral liver & & & \\  & disease: 160 ALD patients) & METAVIR & Manual thresholding & \\  & Stains: H&E-Suffman, MT, & Knodell & & Semi-automated \\  & Spicro-Sirus red & & & & \\ \hline \multirow{4}{*}{[PERSON] et al. 2000 [18]} & 48 samples (CHC patients), & & & & \\  & 11 normal as controls & & & User interference & (0.72 \(\pm\) 0.83, \\  & Stain: picro-Sirus red & & & & \\ \hline \multirow{4}{*}{[PERSON] et al. 2001 [19]} & 98 samples (HCV-chronic & & & & \\  & hepatitis patients) & & & & \\  & Stain: picro-Sirus red & & & & \\ \hline \multirow{4}{*}{[PERSON] et al. 2003 [20]} & 161 samples (chronic viral & & & & \\  & hepatitis patients (B, C or D) & & & \\  & Stains: H&E, Periodic Acid & & & \\  & Scitl, MT, Perts’ & & & \\ \hline \multirow{4}{*}{[PERSON] et al. 2003 [21]} & 46 samples (BA fibrosis & & & \\  & index patients) & - & & \\  & Stain: Azan Mallory & & & \\  & 30 sections (from & & & \\  & 300 CSt samples) & (modified) & & \\  & Stain: picro-Sirus red & & & \\ \hline \multirow{4}{*}{[PERSON] et al. 2000 [23]} & 30 samples (CHC patients) & & & & \\  & Stains: H&H, Malory trichrome & & & \\ \hline \multirow{4}{*}{[PERSON] et al. 2004 [24]} & 214 samples (HCV patients) & \multirow{4}{*}{[PERSON]. [PERSON]} & - & & \\  & Stain: Perf’s & & & & \\ \hline \multirow{4}{*}{[PERSON] et al. 2005 [25]} & 164 samples (CHC patients) & & & & \\  & Stains: H&E, trichrome & & & \\  & & & & & \\  & 25 samples (from HVC, 20 IFN & & \\  & treatment patients) & - & & & \\  & Stains: H&H, Azan-Mallory & & \\ \hline \hline \end{tabular}
\end{table} 
Table 2: Comparison of works using exclusively semi-quantitative examinations for collagen proportionate area (CPA) calculation and combinatorial systems employing digital image analysis (DIA) with histology activity index (HAI) performance verification.