## 2 Materials and Methods
### Isolation and Characterization of OPCs  
For the prefractionation, the crude extract was dissolved in 96% ethanol and separated by classical column chromatography with a SephadexTM LH-20 (50 g) column (43 \(\times\) 2.5 cm). Separation via column chromatography and all following steps were performed six times. About 5 mL of crude extract was loaded on the column end and first eluted with EtOH/H\({}_{2}\)O (96/4, \(v/v\)) under isocratic conditions. Collection of the fractions was performed by using a fraction collector (Superrack 2211, LKB Bromma, Stockholm, Sweden). Time of collection was adjusted for all fractions to have a volume of approximately 6 mL. First solvent switch to MeOH/H\({}_{2}\)O (90/10, \(v/v\)) was implemented after eluting fraction 30, and second switch to acetone/H\({}_{2}\)O (70/30, \(v/v\)) was after eluting fraction 150. In total, 240 fractions were collected and afterwards analyzed via high-performance liquid chromatography (HPLC) coupled with HRMS using an LTQ Orbitrap XL mass spectrometer with heated electrospray ionization (HESI) (Thermo Fisher Scientific, Dreieich, Germany) in negative ionization mode coupled with a Nexera XR LC-20 AD pump, Nexera XR SIL-20 AC autosampler and CTO-10 AS vp column oven (all Shimadzu Deutschland GmbH, Duisburg,Germany). The HRMS parameters are shown in Supporting Information Table S1. For the chromatographic separation, a Nucleotide phenyl-hexyl column (100 \(\times\) 2 mm, 3 \(\upmu\)m) with precolumn (4 \(\times\) 2 mm) (both Macherey-Nagel GmbH & Co. KG, Duren, Germany) was utilized. The separation was carried out with a constant flow rate of 0.3 mL/min using solvents (A) ACN + 0.1% formic acid (FA), (B) H\({}_{2}\)O + 0.1% FA with the following gradients: 0 min, 5% A; 30 min, 100% A; 32.1 min 5% A (total length of the method was 35 min). The column oven was set to 35 \({}^{\circ}\)C throughout the method. Data analysis was performed using the Xcalibur 3.1 software (Thermo Fisher Scientific) and the Skyline 24.1 software (MacCoss Lab Software, Seattle, WA, USA) where all raw data files of the analyzed fractions were uploaded. All raw data were searched for exact masses specific for known OPCs based on a mass list by [PERSON] et al. (2018) and [PERSON] et al. (2018) via Skyline. Based on these results, four enriched fractions with similar OPC pattern were combined out of the 240 Sephadex fractions. Figure 2 gives an overview of the performed fractionations and their output. The fractions (presumably DiF: 188 mg yield; TriF: 139 mg yield; TetF: 39.0 mg yield; PenF: 108 mg yield) were evaporated to dryness, lyophilized and dissolved in ACN/MeOH (4/1, \(v/v\)) for further fractionation and purification. The subsequent fractionation was performed with a Jasco HPLC system with florescence detection (FLD) (Jasco Deutsch-land GmbH, Pfungstadt, Germany) under hydrophilic interaction liquid chromatography (HILIC) conditions for all enriched fractions except DiF. As a stationary phase for the chromatographic separation, a LiChrospher 100 Diol column (250 \(\times\) 4 mm, 5 \(\upmu\)m) with precolumn (4 \(\times\) 4 mm) (both Merck) was utilized. With a constant flow rate of 3.5 mL/min, the following gradient with solvents (A) ACN and (B) MeOH/H\({}_{2}\)O (95/5, \(v/v\)) was applied: 0 min, 100% A; 1 min, 100% A; 25 min, 70% A; 25.1 min 60% A; 35 min, 60% A; 35.1 min, 100% A (total length of 38 min) [11; 21]. For detection, the following parameters were applied: \(\lambda_{\text{em}}=316\) nm; \(\lambda_{\text{ex}}=276\) nm. A volume of 100 \(\upmu\)L of the enriched fractions was injected per run, and subfractions were collected by FLD signals. For the TriF, in total, 21 subfractions (TriS), for TetF 28 subfractions (TetS) and for the PenF 10 subfractions (PenS) were collected. An exemplary chromatogram of TriF separation is available in Supporting Information Figure S1.