Of these, JAZ proteins have a conserved TIFY (also known as ZIM) domain containing a core TIF[F/Y]XG motif near the N-terminal region of JAZ protein sequences, and a JA-associated (also named CCT_2) domain which contains the extremely conserved sequence \"SLX\({}_{2}\)FX\({}_{2}\)KRX\({}_{2}\)RX\({}_{5}\)PY\", located in the C-terminus [31; 32; 33]. In fact, the TIFY domain is not only necessary for JAZ proteins to recruit transcriptional co-repressors like TPL or TPRs via interacting with the NINJA protein [22], but also functions to mediate the paired interactions of JAZ proteins to form homo- and heterodimers [34]. The Jas domain, on the other hand, mediates the JA-Ile dependent interaction of JAZ protein with COI1, or the interaction of JAZ proteins with various TFs [30]. Interestingly, several JAZ proteins, like _Arabidopsis_ AtJAZ5-AtJAZ8 and AtJAZ13 also have additional ethylene-responsive elements binding factor-associated amphiphilic repression (EAR) motifs that can recruit TPL/TPRs in the absence of NINJA [35; 36], thus providing additional functional paths for JAZ proteins in plants. JAZ proteins were first identified in _Arabidopsis thaliana_ in 2007 [19], and are widely present in the green plant lineage. For instance, there are 13, 34, 15, 18 and 13 JAZ proteins identified in _A. thaliana_[33], _Triticum aestivum_[37], _Oryza sativa_[38], _Heeva brasiliensis_[39], and _Solanum Lycopersicum_[40]. Next, functional studies indicated that different _JAZ_ genes have varied biological function. _Arabidopsis_ AtJAZ4 is involved in regulating the development of root, hypocotyl, and petiole [41], and AtJAZ proteins promote growth and reproductive success partially by attenuating the abnormal metabolic effects of an unrestrained immune response [42]. Likewise, MpJAZ, a homolog of AtJAZ, regulated cell growth and reproductive fitness in _Marchantia polymorpha_[43]. In addition, overexpression of _VqJAZ7_ enhanced resistance to powdery mildew by controlling cell death and the accumulation of superoxide anions [44]. TaJAZ1 positively regulated powdery mildew resistance via up-regulating expression of defense-related gene _TaPRI2_ and increasing reactive oxygen species accumulation in wheat [45]. In rice, up- or down-regulation of _OsJAZ1_ or _OsJAZ9_ resulted in drought response or salt sensitivity [46; 47]. It has also been reported that _Glycine soja_ CsJAZ2 positively regulate salt and alkali stress tolerance [48]. More importantly, several lines of evidence have revealed the key role of JAZ proteins in biosynthesis of plant specialized metabolism such as alkaloids, artemisinin, and tanshinone. In _Artemisia annuua_, AaJAZ8 negatively regulated the biosynthesis of artemisinin, a first line of defense against malaria, in response to JA elicitation [24]. In _Salvia mitiformis_, overexpression of _SmJAZ3_ and _SmJAZ9_ reduced tanshinone content [49]. Therefore, _JAZ_ genes have a broad role in regulating adaptability to environmental challenges, and modulate development and specialized metabolism in different plants. _Mentha canadensis_ L. belongs to the _Lamiaceae_ family, is a widely cultivated aromatic plant, and is also a common medicinal plant in China [50; 51]. Furthermore, _M. canadensis_ and its relatives are a source of high-value natural products including essential oils (EOs) widely used in cosmetics, aromotherapy industries, and also exhibit natural antioxidant properties, antibacterial properties, and pharmaceutical value [52; 53; 54]. These species are also promising bioenergy feedstocks for ethanol production [50; 55] or use as natural insecticides for pest management in agriculture [56]. Meanwhile, pioneering studies have found that monoteres including (\(-\))-Limonene, (\(-\))-Carvone, (\(+\))-Menthofuran, (\(-\))-Menthone, and (\(-\))-Menthol, a kind of C\({}_{10}\) class of terpenoid, are the major constituents of EOs in mint.