## 3 Results
### Clinical Research  
Evaluation of the effectiveness of the method of activation of reparative processes in the tissues of the decubitus wound by LTP discharges was carried out at the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology clinic using a specialized device for WP activation. The activation procedure was performed by chipping along the border of problem areas (Figure 4). All patients participated in this part of the study (38 people in the experimental group and 29 people in the control group). At the start of treatment, all DUs had the appearance of open, long-term nonhealing ulcerative-necrotic defects with a moderately severe inflammatory reaction and obvious WP stagnation: fibrin plaque, necrosis foci, rare loci of flaccid granulations, edematous rigid edges, exudation, etc. Local therapy was of an urgent complex nature, and was carried out taking into account the phase of the complicated wound process and, in addition to standard preventive measures, was focused on accelerated cleansing (necrolysis) and stimulation of wound-defect healing. Within the framework of the above concept in all 38 patients (main group), since the start of treatment, we performed WP activation by exposure to cold glow discharge plasma. The developed method of WP activation by LTP discharges contributed to accelerated necrolysis, which in most cases proceeded in parallel with the growth and maturation of granulation tissue in the DU. A comparative assessment of WP indicators in cohorts was performed (Table 1). According to the key macroscopic parameters, it can be seen that the main group was ahead of the control group by about 6-7 days (\(p<0.05\)). The most pronounced intergroup differences were in the duration of necrolysis (more than 8 days). Figure 4: Technique for the treatment of pressure sores by the method of activation by LTP discharges. In addition, activation of WP by LTP discharges favored a decrease in wound exudation and relief of perifocal inflammation at an earlier time. In a cytological scraping from the surface of the DU, the percentage ratio of the neutrophil group of cells and cells responsible for proliferation at the beginning of the study was 70/30%, and 40/60% in the main group and 55/45% in the control group by the end (conditionally 30 days) (\(p<\) 0.01). Against the background of regular exposure of the tissues of the wound zone to LTP discharges, an improvement in the status of the DU was also noted according to the standard Bates-Jensen scale, most noticeable by the end of the third week of complex therapy (Table 1). The dynamics of the bedscore condition in the main and control clinical groups is shown in the photographs (Figures 5 and 6). \begin{table}
\begin{tabular}{c c c c} \hline \hline
**Index** & **Main Group (_n_ = 38)** & **Control (_n_ = 29)** & _p-Value_ \\ \hline Terms of complete cleansing of DU & 11.2 \(\pm\) 0.5 & 19.8 \(\pm\) 0.01 & \textless{}0.05 \\ (M \(\pm\) m), days & 12.4 \(\pm\) 0.2 & 19.0 \(\pm\) 0.4 & \textless{}0.05 \\ Time of appearance of the first & 32.4 \(\pm\) 1.0 & 39.4 \(\pm\) 0.1 & \textless{}0.05 \\ granulations in the wound (M \(\pm\) m), days & 32.4 \(\pm\) 1.0 & 39.4 \(\pm\) 0.1 & \textless{}0.05 \\ Beginning of epithelialization of DU & 27.4 \(\pm\) 0.8 & 34.0 \(\pm\) 0.6 & \textless{}0.05 \\ Relief of paravelinar inflammation & 28.9 \(\pm\) 0.3 & 34.7 \(\pm\) 0.1 & \textless{}0.05 \\ (M \(\pm\) m), days & 2.8 \(\pm\) 0.2\% & 2.0 \(\pm\) 0.5\% & \textless{}0.05 \\ The rate of epithelialization of the DU & 31/26/24 & 32/30/27 & - \\ DU scores on the Bates-Jensen wound & 36 [30; 53] & 44 [37; 63] & \textless{}0.05 \\ assessment tool in days 14/21/28, M & 31/26/24 & 32/30/27 & - \\ Terms of treatment, Me [30; 53] & 36 [30; 53] & 44 [37; 63] & \textless{}0.05 \\ \hline \hline \end{tabular} Mean values in each group are presented.  
\end{table} 
Table 1: Parameters of the wound process in clinical groups. Figure 5: Dynamics of the pressure sore in the main group: (**a**) before treatment and (**b**) on the 30 th day.