## 1 Introduction  
Despite decades of research into the interaction between cells and nanoparticles, the literature is pervaded with insufficiently comprehensive, methodologically limited reports that frequently contradict each other's findings with regard to the effect of specific physicochemical characteristics of the nanoparticles, such as chemical composition, crystallinity, size, morphology, charge, and aspect ratio, among others, on their internalization and intracellular fate. For example, for each report demonstrating that eukaryotic cells have a greater affinity for smaller nanoparticles [1; 2; 3], two reports can be found that demonstrate the opposite, namely a direct proportionality between the cell viability and the particle size [4; 5; 6; 7; 8; 9]. Likewise, the number of literature reports arguing in favor of the greater affinity of cells for negatively charged nanoparticles [10; 11; 12] is counterbalanced by the reports demonstrating the greater affinity for positively charged nanoparticles [13; 14], as well as reports showing nil difference between the two [15]. Even when comparisons are limited to a single cell type, such as mesenchymal stem cells (MSCs), which lie at the focus of this study, there are still considerable incoherencies pervading the literature. For example, while some reports provide evidence in favor of the inverse dependence of the degree of differentiation of MSCs on the particle size [16; 17], other reports demonstrate the direct dependence [18; 19], with the rest of the studies providing mixed findings, such as the greatest effect of particles in the medium size ranges [20; 21], or the different effect of differently sized particles on markers dominant in early, middle, and later stages of the differentiation process [22; 23]. This lack of consensus with respect to the causative grounds underlying the interaction of nanoparticles with cells indicates the complexity, and the existence of a multitude of physicochemical factors, that synergistically determine the interaction with cells and other biological entities. It also highlights the need for the assessment of this fundamental subject from new angles, using innovative experimental approaches. Methodological novelties offer new perspectives on the same old problematics, and often translate into enriched insight on the given topic. Inspired by an analogy with the theme of a movie about movies, titled Lisbon Story, one such conceptually unconventional method for gaining insight into the interaction between nanoparticles and cells is proposed here. [PERSON] Lisbon Story, a movie that this author watched at the Belgrade FEST in 1995 and that exists at the time of writing this piece only in three analog 35 mm prints, is to a large extent a story about the writer's block, about the lack of inspiration for creative work befalling a burned-out auteu. In the sciences, such lack of inspiration for engaging in conceptualization and testing of groundbreaking ideas often drives scientists to the mainstream of conventional, paradigmatic research. In Lisbon Story, the film artist sought by the protagonist deals with this writer's block by strapping a camera to his back and taking random images of Lisbon, with the idea that each of these accidental images would bear a greater significance for our lives than the best planned schemes. As in [PERSON]'s Blowup, as it were, magnification of the fine details in these images, and meticulous subjection thereof to scrutiny can open whole new universes before the explorer and his community; a point that originates from the domain of arts, but even more strongly resonates with the core of the scientific method. In this conceptually experimental study, an analogous method involving a random, \"Take 1\" capture of an image showing the interaction of nanoparticles with cells was set to take place, and its detailed inspection was performed to see how far, and in what direction, it will take the investigator. Numerous points can be invoked as justifications of this unorthodox method.