## 3 Results
### General Results
In some cases, PRP promoted tissue healing but did not fully restore normal ultrasound features, particularly in chronic hindlimb PSLD cases [18]. Randomized trials demonstrated that PRP enhanced lameness reduction and matrix organization; however, long-term return-to-work rates were comparable to those achieved with extracorporeal shockwave therapy (EST) [46] or bone marrow aspirate concentrate (BMAC) [47] treatments. On the other hand, in experimental models, PRP increased collagen production, the glycosaminoglycan (GAG) content, and cellularity [50]; stimulated neovascularization and blood flow; improved fibrillogenesis; and reduced inflammation [48; 49]. Histological studies confirmed enhanced collagen fiber alignment, although fibroblast and vascular responses varied [52; 54]. PRP was scored as positive in all case series studies [17; 18; 37; 38; 39; 40; 41; 42; 43], in two [44; 45] out of four randomized clinical trials, in six [48; 49; 50; 51; 52; 53] (85.7%) out of seven experimental studies in which PRP was used as the only treatment, and in one [55] of out two experimental studies in which PRP was evaluated together mesenchymal stem cells. In general, 18 (82%) of out 22 studies were scored with positive outcome, 2 [46; 47] (9%) of out 22 studies were scored with negative outcome, and 2 [54; 56] (9%) out of 22 studies had a neutral outcome. Where reported, the magnitude of improvement in PRP-treated groups varied widely: lameness scores decreased by 30-60% (vs. 10-25% in controls) in RCTs [44; 45], while ultrasonographic fiber alignment improved by 40-80% in experimental studies [48; 49; 50]. Return-to-work rates ranged from 70-89% for PRP vs. 50-60% for saline controls [17; 39; 45], though these differences were not always statistically significant due to small sample sizes. \begin{table}
\begin{tabular}{p{113.8 pt} p{113.8 pt} p{113.8 pt} p{113.8 pt} p{113.8 pt} p{113.8 pt}} \hline \hline
**Study** & **Study Type, Number of Animals, and Objectives** & **Study Design** & **Results and Adverse Effects** & **Length of Follow-Up** & **Outcome** \\ \hline \multirow{9}{*}{[PERSON] et al. [18]} & Case series, 11 hours with 18 supervisory ligament (SJ) branch (SJL) injuries. To evaluate the effect of an autologous PRP product on lanneness scores and US changes. & 2.5 mL of PRP obtained by a gravitational method was injected L, only once perforated structure. Hoses were evaluated by a lameness examination and US before and 3 months after treatment & \multirow{2}{*}{20 months} & \multirow{2}{*}{Positive} \\ \cline{1-1} \cline{5-5}  & Case series, 7 horses, 5 with SDFT, 1 with inferior check ligament injury, and 1 with tendmothey of the deep digital record (DoDFT). To evaluate the effect of an autologous PRP product (autologous command plasma (ACP) on lanneness scores and US changes. & 2.5 mL of PRP obtained by a gravitational method was injected L, only once perforated structure. Hoses were evaluated by a lameness examination and US before and 3 months after treatment & \multirow{2}{*}{20 months} & \multirow{2}{*}{Positive} \\ \cline{1-1} \cline{5-5}  & Case series, 7 horses, 5 with SDFT, 1 with inferior check ligament injury, and 1 with tendmothey of the deep digital record (DoDFT). To evaluate the effect of an autologous PRP product (autologous command plasma (ACP) on lanneness scores and US changes. & 2.5 mL of PRP obtained by a gravitational method was injected L, only once perforated structure. Hoses were evaluated by a lameness examination and US before and 3 months after treatment & \multirow{2}{*}{20 months} & \multirow{2}{*}{Positive} \\ \cline{1-1} \cline{5-5}  & Case series, 9 horses with SDFT, 1 with inferior check ligament injury, and 1 with tendmothey of the deep digital record (DoDFT). To evaluate the effect of an autologous PRP product (autologous command plasma (ACP) on lanneness scores and US changes. & 2.5 mL of PRP obtained by a gravitational method was injected L, only once perforated structure.