## 5 Microarray Results
\begin{table}
\begin{tabular}{c c c c} \hline \hline
**Network** & **Molecules in Network** & **Score** & **Focus Molecules** & **Top Diseases and Functions** \\ \hline Activated ZAP-70, Antigen-bearing MHC Class & & & \\ II: TCR complex:CD4:Lck(7505), AP-1 & & & \\ Clathrin-coated nonameric, AP-1 & & & \\ Complex:Arf1-GTP:Clathrin & & & \\ Triskelion:Nonameric, CD4, CD74, collagen & & & \\ type i (family), cytokine, GADD45G, & & & \\ HLA-DQA1, HLA-DRB5, IFNG-regulated & & & \\ genes with GAS promoter elements, IgE, IL12 & & & \\ (family), Interferon alpha, Mapk, MERTK, & & & \\ MHC, MHC class I (complex), MHC class II & & & \\ (complex), MHC II, MHC/antigen, Nfat & & \\ (family), Ngf, Nonameric complex in COPII & & & \\ vesicle, P38 MAPK, PI(4)P:AP- & & & \\
2:clathrin:ITSNs:EPS15:REPS1:SGIP1: & & & \\ NECAPs:AAK1:CLASP proteins: cargo: F-BAR & & & \\ proteins: BAR domain proteins: ARP2/3 & & & \\ complex: WASL: f-actin: HIP dimers: DNM: & & & \\ GDP: SYNJs: auxillin: HSPA8: ATP, PLC gamma, & & \\ PPP1R3C, RNA polymerase II, Rnf125, Tgf beta, & & \\ TGN-lysosome vesicle with nonameric, TTL7, & & & \\ ZAP-70 and ITK tyrosine kinases & & & \\ \hline Ap2, Cbp/p300, DENND4A, DNAJB1, & & & \\ DNAJB1/HSP70, Dynamin, Fascin, Hdac, heat & & & \\ shock-inducible proteins, histone deacetylase, & & & \\ HSP, HSP40:HSP70:ADP:nascent protein, HSP70:ATP:nascent protein, & & & \\ HSP70 co-chaperone, HSP70: DNAJB1, HSP70: DNAJB1:Ac-K80-HSF1, & & & \\ DNAJB1:Ac-K80-HSF1 & & & \\ HSP70:DNAJB1:Ac-K80-HSF1 trimer:target & & & \\ gene, HTT aggregate, MYC, MYH7B, N-CoR, & & & \\ OSR1, PFK, PF1, Bar, SERCA, & & & \\ SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target & & & \\ gene, SMAD1/5/9, Sprr2e, STATI Dimer, & & & \\ thyroid hormone receptor, Tropomyosin, UCP3, & & & \\ YAP/TAZ & & & \\ \hline Activin (family), CCN1, CCN2, collagen, & & & \\ Collagen type I (complex), Collagen type II, & & & \\ Collagen type IV, Collagen(s), collagenase, & & & \\ elastase, ERK1/2, FAM20:C:FAM20C substrates, & & & \\ FGFR, gelatinase, GGTase I, growth hormone, & & & \\ HLA/DQ, IGF receptor, Integrin, ITG86, & & & \\ Laminin (complex), LATS, LRG1, Mirl122a, b, & & & \\ Mmp, MMP8, OTUD1, PDGF-BB, Pkg, SMAD, & & & \\ specific granule lumen proteins, TCF, TEAD, & & & \\ tertiary granule lumen proteins, TSPAN4 & & & \\ \hline \hline \end{tabular}
\end{table} 
Table 3: _Cont._ \begin{table}
\begin{tabular}{l l l l l} \hline \hline
**Categories** & \begin{tabular}{l} **Diseases or Functions** \\ **Annotation** \\ \end{tabular} & \(p\)**-Value** & **Molecules** & **\# Molecules** \\ \hline \multirow{3}{*}{Cardiac Fibrosis} & Fibrosis of heart & \multirow{3}{*}{3.82 \(\times\) 10\({}^{-5}\)} & \
\begin{tabular}{l} Airm, ARG1, ATF3, CCN2, \\ CYP1B1, EGR1, HAND2, \\ LCN2, PFKFB1, SCN5A \\ \end{tabular} & 10 \\ \hline \multirow{2}{*}{Cardiac Fibrosis} & Fibrosis of ventricular wall & 0.0217 & SCN5A & 1 \\ \hline \multirow{2}{*}{Cardiac Fibrosis} & Fibrosis of heart ventricle & 0.0306 & LCN2, SCN5A & 2 \\ \hline \multirow{2}{*}{Cardiac Fibrosis} & \multicolumn{1}{l}{Perivascular fibrosis of artery} & 0.0376 & OTUD1 & 1 \\ \hline \multirow{2}{*}{Cardiac Dysfunction, Left ventricle} & \multirow{2}{*}{
\begin{tabular}{l} Interstitial fibrosis of \\ left ventricle \\ \end{tabular} } & \multirow{2}{*}{0.0989} & \multirow{2}{*}{LCN2} & 1 \\ \hline \multirow{2}{*}{Cardiac Fibrosis} & Myocardial fibrosis & 0.156 & HAND2 & 1 \\ \hline \hline \end{tabular}
\end{table} 
Table 4: Disease and biofunction cardiac fibrosis.