## 1 Introduction  
The use of non-soluble polymers is gaining presence in the chemistry arena [1, 2]. There is no universal solvent that can be considered as compatible with all of them due to the broad available spectrum of these kinds of polymers. The identification of the most adequate solvent in terms of compatibility and/or swelling could be determined through several parameters. As a result, certain solvents are considered as good solvents, while the others are not (called \"bad\" solvents). This classification was made mainly based on the \"Solubility\" parameters of solvents and solutes [3]. In this work, the Hildebrand \"Solubility\" parameters (\(\delta\)) will be adopted for analyzing the adequacy of a family of solvents in our current research in green chemistry. This parameter is mainly derived based on the cohesive energy of the chemical compounds [4]. It also considers the addition of other parameters that were introduced by [PERSON] [5] to account for dispersion forces, polarity, and hydrogen bonding [6]. Insummary, materials that have similar or close \(\delta\) values are likely miscible [7]. The solubility parameters have a great impact on the polymers industry to choose the most convenient solvent. Thus, they help in enhancing the synthetic processes of polymers, where the unreacted monomers could be easily removed, minimizing the by-products and reducing several health and/or environment related concerns [8]. Furthermore, they are playing an enormous role in several applications of the polymer science, such as kidney dialysis, soft contact lenses, and surgical implants, among others [8]. The use of the so-called good solvents, which can be defined as those that show a similar or close \(\delta\) with the polymer, should preserve its morphological properties. On the other hand, the use of \"bad\" solvents could cause an alteration in the morphology of the resin. This phenomenon is known as \"osmotic shock\" phenomenon, which is also observed due to the low mechanical stability of the resin. Osmotic shock could affect the reaction rate as a result of the damaged morphological characteristics of the beads. The mild damage usually appears as a peeling/flaking in the outer shell of the bead, but the bead itself remains intact. Whereas in the higher severity level, the dented tracks become as a major characteristic of the bead, and in the escalated levels dimples and even fractures are most likely taking place. Crosslinked non-soluble polymeric supports play an important role in the field of heterogeneous reactions [9]. Most importantly, these supports are the base for the solid-phase peptide synthesis (SPPS) [2], which is the method of choice for the synthesis of peptides for both research and industrial purposes. In SPPS, the growing peptide is anchored to the polymeric support, which acts as a kind of protecting group [2; 9; 10]. In principle, the use of solvents is not limited to a prerequisite of the solubility of these supports in the different solvents used in the reactions, as occurs in the case of homogeneous phase. The solid-phase is compatible with a broad range of solvents. However, the solvents used in SPPS should possess some properties because reactions do not take place in solid state, for instance, the ability to swell the solid support for allowing the reactants to reach the active sites. Furthermore, they must solubilize the soluble reactants (protected amino acids, coupling reagents, deprotection reagents). The presence of crosslinking enables the swelling of the polymer to a certain elastic limit that is imposed by the crosslinks themselves. In some sense, swelling is a kind of solvation process. Swelling is also controlled by the type of solvent in contact with them [11]. At the same time, crosslinking confers a certain degree of mechanical stability to the resin. Therefore, a certain balance should be kept, which assures the mechanical stability as well as the swelling capacity.