# Evaluating the Metabolomic Profile and Anti-Pathogenic Properties of _Cannabis_ Species
## 3 Results and Discussion
### Cannabis Active Compounds  
It is reported that _Camanabis_ is one of the medicinal plants that possess a high metabolomic profile with a diverse range of essential bioactive compounds used for numerous pharmacological purposes [60]. For instance, a previous study by [PERSON] et al. [61] revealed that more than 600 compounds have been discovered, with 180 belonging to the cannabinoids family and including many terpenes. In addition, [PERSON] and [PERSON] [10] indicated that their biosynthesis involves the alkylation of olivetolic acid with geranyl diphosphate. A recent study by [PERSON] et al. [62] reported that the abovementioned reaction leads to the formation of cannabigerolic acid CBGA as shown in Figure 3, which is a precursor molecule for numerous other cannabinoids, such as \(\Delta^{9}\)-tetrahydrocanabinol (\(\Delta^{9}\)-THC), which is regarded as the most important natural cannabinoid [63]; cannabidiol (CBD); cannabigerol (CBG), cannabinoid (CB); cannabichromene (CBC) [63]; \(\Delta^{8}\)-tetrahydrocanabinol (\(\Delta^{8}\)-THC) [64]; \(\Delta^{9}\)-tetrahydrocannabivarin (THCV) [64]; cannabivarin (CBV) [64]; and cannabidivarin (CBDV) [64]. Some researchers discovered the highest amount of THC in female infloresances of _Camanabis_[65]. Another recent research study discovered that biologically active cannabinoids such as \(\Delta^{9}\)-THC, (25.04%) and CBD (rescorcionol, 2-p-mentha-1,8-dien-4-yl-5-pentyl) (50.08%) were found in _Camanabis_ resin in a high percentage [66]. Cannabinoids are the best-known secondary active metabolites reported extensively in modern and scientific literature due to a considerable number of studies demonstrating their effectiveness in the treatment of some infections caused by a wide range of pathogens [67]. Consequently, this is a reaffirmation of many previous research studies that asserted that cannabinoids are usually concentrated in the viscous resin produced in structures known as glandular trichomes. These findings prove that the presence of biologically active phytochemicals in high concentrations makes it a valuable source to be used in herbal preparation for different ailments. However, attention has mostly been given to cannabinoids resulting in many other compounds, such as nitrogen compounds, amino acids, hydrocarbons, carbohydrates, organics, and fatty acids, not being thoroughly investigated for their medicinal potential. In addition, the full potential of _Camanabis_ has not been sufficiently exploited because some active molecules have not been defined and their cellular and molecular mechanisms that underlie its antimicrobial and anti-inflammatory activity are not investigated nor understood in depth. However, it is noteworthy to mention that beyond _Camanabis_, several plants have been reported to possess cannabinoid-like active compounds that interact with the cannabinoid system in one way or the other. For instance, studies conducted have reported the roots of _Otanthus maritimus_ L. to be the main receptors of CB1 and CB2 of cannabinoids [68; 69]. In addition, Ruta gravelohens, which is used in traditional medicine for its healing properties as fresh herbs, infusions, decoctions, powders, or oils [70; 71], was found to have a selective affinity to the CB2 receptors as reported by [PERSON] et al. [72]. A recent study by [PERSON] et al. [73] revealed carrots (_Dancus carota_, L) contain a high concentration of falcarinol (FaOH), which acts as a moderate skin irritant, aggravating histamine-induced edema skin, and showed receptor affinity to both CB1 and CB2 with a CB1 antagonist profile [74]. Catechins and epi-catechin compounds in tea (_Camellia sinensis_ L.) were found to be receptors of CB1 [75]. Furthermore, KavaKava (_Piper methyticum forster_) also known as \"intoxicating pepper\", which is used as a traditional medicine to cure pain, headaches, convulsions, menstrual pain, and skin diseases [76], was reported to have the ability to activate the CB1 and CB2 receptors [77].