## 3 Results
### Identification of Differentially Expressed Genes and Gene Ontology Analyses
\begin{table}
\begin{tabular}{c c c c} \hline \hline
**Gene Name** & **Fold Change** & **Description** & **Related Function** \\ \hline ACAN & 177.4 & Aggrecan & Cell differentiation, extracellular matrix \\ NGF & 136.7 & Nerve growth factor & Apoptotic process, cell death, cell \\ HAPLN1 & 106.0 & Hyaluronan and proteoglycan link & Extracellular matrix \\ NPR3 & 102.8 & Natriuretic peptide receptor 3 & Cell proliferation \\ CTNND2 & 86.6 & Catenin delta 2 & Cell differentiation \\ ADM2 & 81.4 & Adrenomedullin 2 & Angiogenesis \\ TRIM67 & 58.4 & Tripartite motif containing 67 & Cell differentiation \\ ADAMTS14 & 55.6 & ADAM metalloproteinases with & Extracellular matrix \\  & & thrombospondin type 1 motif 14 & \\ DLGAP5 & 52.7 & Discs large homolog-associated & Cell cycle, cell proliferation \\  & & protein 5 & Cell proliferation \\ ADRA1B & 45.1 & Adrenocopter alpha 1B & Cell proliferation \\ LGR5 & 45.1 & Leucine-rich repeat-containing & Cell differentiation, cell proliferation \\ TENM2 & 41.3 & Teneurin transmembrane protein 2 & Cell differentiation \\ SLITRK1 & 41.2 & SLIT and NTRK like family & Cell differentiation \\ MAP2 & 38.3 & Microtubule associated protein 2 & Cell differentiation \\ IL7R & 35.5 & Interleukin 7 receptor & Cell differentiation, cell proliferation, \\ GLI1 & 33.3 & GLI family zinc finger 1 & Immune response \\ KRT33B & 32.6 & Keratin 33B & Cell differentiation \\ COL1A1 & 27.8 & Collagen type I alpha 1 & Cell differentiation, \\ HILS1 & 25.5 & Histone linker H1 domain, & extracellular matrix \\ ANK2 & 25.5 & Ankyrin 2, neuronal & Cell differentiation \\ PRELP & 25.0 & Proline/arginine-rich end & Cell differentiation, extracellular matrix \\ KRT34 & 23.2 & Keratin 34 & Cell death, cell differentiation \\ TTK & 19.6 & TTK protein kinase & Cell cycle \\ ASB2 & 18.7 & Ankyrin repeat and SOCS & Cell differentiation \\  & & box-containing 2 & Cell differentiation \\  & & Pregnancy-specific & Cell migration \\ PSG1 & 17.8 & beta-1-glycoprotein 1 & Cell migration \\ ASPN & 16.9 & Asporin & Extracellular matrix \\ RSPO2 & 16.5 & R-Spondin 2 & Cell differentiation \\ \hline \hline \end{tabular}
\end{table} 
Table 2: Genes downregulated >10-fold in 3D- compared to 2D-cultured sPDLSCs. \begin{table}
\begin{tabular}{c c c c} \hline \hline
**Gene Name** & **Fold Change** & **Description** & **Related Function** \\ \hline SOCS2 & 11.3 & Suppressor of cytokine signaling 2 & Cell differentiation \\ CXCL3 & 11.2 & CXC motif chemokine ligand 3 & Cell migration, immune response, \\ GEM & 11.1 & GTP-binding protein overexpressed & Cell migration, immune response \\  & & in skeletal muscle & inflammatory response \\  & & Zinc finger protein 443 & Cell cycle, immune response \\ ZNF443 & 10.8 & Zinc finger protein 443 & Apoptotic process, cell death \\ MGP & 10.7 & Matrix Gla protein & Extracellular matrix \\ TNIK & 10.5 & TRAF and NCK interacting kinase & Cell differentiation \\ NR4A3 & 10.3 & Nuclear receptor subfamily 4 group & Cell differentiation, cell proliferation, \\  & & A member 3 & immune response \\  & & Chondroitin sulfate & Cell proliferation \\ CSGALNAACT1 & 10.3 & \(N\)-acetylgalactosaminyltransferase 1 & Cell proliferation \\  & & Cathepsin S & Immune response \\ \hline \hline \end{tabular}
\end{table} 
Table 1: Cont.