## 7 Human Safety Data with an Indication of the Role of Health Care Providers  
Many scientific studies proved that GTE have the potential to be used for different diseases [111] (Figure 3). These concern antimicrobial and neuroprotective activities, anti-inflammatory, photoprotective action, and possibilities for hyperlipidemia, hyperuricemia, diabetes, overweight, heart, and cerebrovascular diseases, genital warts treatment, and anticancer potential. Figure 3: Beneficial effects of green tea extracts (GTE). Lately [PERSON] et al. reviewed GTE applications and indicated that patients with various types of cancers could benefit from its usage [112]. Furthermore, it was noted that overweight women taking GTE, capsaicin, and ginger co-supplements, could observe beneficial effects connected with weight, body mass index, markers of insulin metabolism and plasma glutathione levels [113]. Green tea supplements have many indications, but there is not enough scientific evidence to support these uses. Taken orally, it may have a positive effect on hyperlipidemia [114]. GTE also reveals neuroprotective properties and can be used against depression [111]. For diabetes, many studies confirmed a positive influence on glycosylated hemoglobin (HbA1c). However, several articles reported lack of GTE effect on insulin sensitivity, fasting blood glucose, and glucose tolerance [115; 116]. Interestingly, it was found that drinking 3-4 cups of GTE per day could decrease total cancer and respiratory disease mortality in women. More than 5 cups a day may lower the risk of all-cause mortality, especially for heart and cerebrovascular disease [117]. Taking 3 or more cups daily (720 mL) could reduce the incidence of stroke [118]. Capsules containing GTE can reveal hypouricemic effects [119]. Furthermore, consuming GTE at least twice each day could be associated with the reduced odds of chronic obstructive lung disease in middle-aged and older adults [120]. GTE, when topically applied, reveals an anti-inflammatory effect on skin and reduces its redness [121]. In can also be used as a topical photoprotective agent [122]. Moreover, a foot bath with green tea polyphenols can improve the treatment of interdigital tine pedia, such as interdigital erythema, desquamation, maceration [123]. Green tea mouthwash may reduce pain, exhibits antimicrobial actions against oral bacteria, and inhibits amylase activity in human saliva. Green tea can also be used in an ointment for genital warts [124; 125; 126]. In general, there is no evident confirmation of EGCG effectiveness in treating medical conditions according to FDA opinion. Studies on obesity/weight loss and diabetes have shown minimal treatment effects and no overall therapeutic benefit. What is essential, oral bioavailability of GTE is minimal and may be a factor in limiting clinical results [127]. Certainly, GTE should not be used instead of the medication prescribed by a physician and without pharmacist consultation. Unfortunately, there are no recommendations for many herbal compounds which could be contaminated with toxic metals or other drugs [128]. The increasing consumption and popularity among patients led to the development of recommendations for GTE use, primarily due to potential side effects (Table 3). It is worth mentioning that there are many different GTE products in community pharmacy e.g., ready-to-drink green tea beverages, food supplement products in capsule and tablet forms. \begin{table}
\begin{tabular}{l p{142.3 pt}} \hline \hline \(\  
A review of [PERSON] at al. on toxicological evidence from laboratory studies confirmed the GTE hepatotoxicityicity in the liver. It was strongly associated with doses and positively correlated with total catechin and EGCG content [138]. Several 159 human intervention studies confirmed toxicological evidence. Catechin-rich green tea preparations resulted in hepatic AEs (adverse event) in a dose-dependent manner when ingested in large bolus doses, but not when consumed as brewed tea or extracts in beverages or even as part of food.