## 3 Results
### Silver Nanoparticles
\begin{table}
\begin{tabular}{c c c c c} \hline \hline
**Material** & **Extract** **(Reference)** & **Cell Line/ Animal Model** & **ICS0/LD50** & & **Results** \\ \hline ME (10\%) of & 36 Wistar rats: & & & Decreased CEA.Ca19, APC and TP53 expression \\ _Morriage oleifera_ & chemical induction & - & & in nano-extract treatment. \\ leaves [23] & by AOM & & & Absence of toxicity in non-tumor cells and \\  & & & & protection against oxidative damage. \\ \hline AE of leaves (LE) & & AgNPs-PE: 1.285 \(\upmu\)g/mL & \(\bullet\) & Induction of apoptosis by ROS. \\ and peel (PE) of _Anmonia_ & HCT-116 & PE: 309.3 \(\upmu\)g/mL & \(\bullet\) & AgNPs-PE are less toxic compared to AgNPs-LE \\ _nurticla_ [31] & & LE: 404.8 \(\upmu\)g/mL & & against macrophages. \\ \hline AE of leaves of & & & & \\ _Mentha_ & HCT-116 & - & Encapsulation of phytochemicals by nanoparticles is \\ _loniglui_ [32] & & & low, so there is no cytotoxic activity. \\ \hline AE of seeds of & & & & The nanoparticles encapsulating the extract induce \\ _Putranijica_ & HCT-116 & PJSNPs: 0.54 \(\upmu\)g/mL & \(\upmu\)g/mL & genotoxicity, triggering cell apoptosis to a greater extent \\  & _rexburghii_ [29] & & & than the free extract. \\ \hline AE, ME, EAE, & & AE: 18.7 \(\upmu\)g/mL & \(\bullet\) & The increased antitumor activity by NPs is \\  & PEE and CE of & & ME: 51 \(\upmu\)g/mL & attributed to an increased apoptotic induction. \\  & leaves of & HCT-116 & EAE: 72 \(\upmu\)g/mL & \(\bullet\) & Greater antitumor activity was observed with the \\  & _Casalpinia_ & & PEE: 69.3 \(\upmu\)g/mL & aqueous extract, compared to the extracts \\  & _pulcherrima_ [30] & & CE: 77 \(\upmu\)g/mL & obtained through solvents. \\ \hline AE, EEAE, NBE of & & & Extracts: 0.625-1.25 & \(\bullet\) & Apoptosis induction via ROS damage. \\ fruits of _Balanites_ & Caco-2 & \(\upmu\)g/mL & \(\bullet\) & No increased antitumor activity was observed \\  & _agsyptiaca_ [35] & & AgNPs: 0.625 \(\upmu\)g/mL & with NPs compared to the functional extracts. \\ \hline EA (70\%) of petals & HCT-15 & Extract: \textgreater{}250 mg/mL & \(\bullet\) & Increased antitumor activity with NPs compared to functional extracts. \\  & of _Rose indica_ [33] & HCT-15 & AE: 150 \(\upmu\)g/mL & \(\bullet\) & Increased antitumor activity with NPs compared \\  & _Vitex negundo_ [34] & HCT-15 & AE: 309.70 \(\upmu\)g/mL & \(\bullet\) & Cell death is attributed to apoptosis due to \\  & & & AE: 176.90 \(\upmu\)g/mL & \(\bullet\) & Apoptosis induction via ROS damage and \\  & AE, EE and PEE & & PEE: 692.10 \(\upmu\)g/mL & \(\bullet\) & Greater antitumor activity with AE and ZnO-A \\  & of seeds of _Crotan_ & & ZnO-EE: 252.50 \(\upmu\)g/mL & compared to other extracts and NPs. The highest \\  & _tiglium_ [36] & & ZnO-EE: 100.20 \(\upmu\)g/mL & activity was achieved by ZnO-AE compared to \\  & & & ZnO-PE: 353.0 \(\upmu\)g/mL & \(\bullet\) & Cell death is attributed to apoptosis due to \\  & & & & & \\ \hline AE of leaves of & & & & \\ _Spondias pimata_ & HCT-116 & \(\upmu\)g/mL & \(\bullet\) & Increased Advisory on DNA fragmentation. \\  & (SpL) [37] & & ZnNPs: 60 \(\upmu\)g/mL & \(\bullet\) & Increased antitumor activity with SplZnONPs \\  & & & & compared to non-extract NPs. \\ \hline AE of aerated & & & & \\ parts of _Deverna_ & Caco-2 & \(\upmu\)g-NPs: 50.81 \(\upmu\)g/mL & \(\bullet\) & Increased antitumor activity with NPs compared \\  & _fortusa_ [38] & & & AE: 136.12 \(\upmu\)g/mL & \(\bullet\) \\  & & & & \\ \hline AE of fruits of & & & & \\ _Anmonia_ & HCT-116 & \(\upmu\)g/mL & \(\bullet\) & The encapsulation of _Anmonia muricata_ extract did not \\  & _muricata_ [39] & & Am-ZnNPs: 60 \(\upmu\)g/mL & exert any additional cytotoxic effect compared to the \\  & & & & administration of ZnNPs alone. \\ \hline \hline \end{tabular}
\end{table} 
Table 1: Most relevant information obtained from the studies included in the systematic review. [PERSON] et al. (2015) obtained an extract of _Rosa indica_ using 70% ethanol.