## 3 Results
According to Figure 3, significant differences were observed between groups in terms of HDL-C, LDL-C, TG, and TC levels, as well as the AIP. As indicated in Figure 3A, although the HDL-C level was highest in the C group, this group was statistically categorized in the same group as the MICT and HICT groups. The lowest HDL-C level was observed in the MICTQ\({}_{10}\) group. In Figure 3B, the LDL-C level was highest in the C group compared to in the other groups, and this difference was statistically significant (\(\chi^{2}\) = 9.246, \(p\) < 0.001, \(\eta^{2}\) = 0.62). The lowest LDL-C level was measured in the MICTQ\({}_{10}\) group, which was statistically different from the MICT group (\(p\) = 0.04, d = 1.65) and the Q\({}_{10}\) group (\(p\) = 0.03, d = 2.35). Figure 3C indicates that the TG level was highest in the C group compared to in the other groups, and this difference was statistically significant (\(\chi^{2}\) = 11.05, \(p\) < 0.001, \(\eta^{2}\) = 0.73). The lowest TG level was recorded in the MICTQ\({}_{10}\) group, which differed significantly from the MICT (\(p\) = 0.04, d = 1.05), HICT (\(p\) = 0.03, d = 1.35), and Q\({}_{10}\) (\(p\) = 0.03, d = 2.25) groups. According to Figure 3D, the TC level was highest in the C group (excluding the HICT group) compared to in the other groups, and this difference was statistically significant (\(\chi^{2}\) = 12.47, \(p\) < 0.01, \(\eta^{2}\) = 0.83). Compared to in the C group, the TC level was significantly lower in the MICT group (\(p\) = 0.003, d = 3.25), Q\({}_{10}\) group (\(p\) = 0.003, d = 3.30), MICTQ\({}_{10}\) group (\(p\) = 0.002, d = 3.02), and HICTQ\({}_{10}\) group (\(p\) = 0.001, d = 6.41). Finally, Figure 3E indicates that the AIP was highest in the C group (excluding the MICT group and Q\({}_{10}\) group) compared to in the other groups, and this difference was statistically significant (\(\chi^{2}\) = 41.00, \(p\) < 0.001, \(\eta^{2}\) = 0.15). Compared to in the C group, the AIP was significantly  
Figure 2: The change in body mass from baseline to the 50 th day is illustrated. C: control group, MICT: moderate-intensity continuous training group, HICT: high-intensity continuous training group, Q\({}_{10}\): coenzyme Q\({}_{10}\) group, MICTQ\({}_{10}\): moderate-intensity continuous training combined with Q\({}_{10}\), and HICTQ\({}_{10}\): high-intensity continuous training combined with Q\({}_{10}\). The changes in body mass days, groups, and day \(\times\) group interaction were analyzed using the [PERSON] test, followed by the Wilcoxon test. ##: differences in body mass between groups were analyzed using the Kruskal-Wallis test, followed by [PERSON]’s multiple comparison test. ns: no significant difference, \(\eta^{2}\): indicates eta squared, *: \(p\) < 0.05, **: \(p\) < 0.01, ***: \(p\) < 0.001.  
lower in the HICT group (\(p\) = 0.03, d = 1.21), MICTQ\({}_{10}\) group (\(p\) = 0.02, d = 2.02), and HICTQ\({}_{10}\) group (\(p\) = 0.01, d = 4.01). According to Figure 4A, the plasma tumstatin levels did not differ significantly among the groups (\(p\) > 0.05). However, as indicated in Figure 4B, the homogenized skeletal muscle samples exhibited significant differences among the groups (\(\chi^{2}\) = 3.918, \(p\) < 0.01, \(\eta^{2}\) = 0.68). According to these findings, the MICTQ\({}_{10}\) group displayed the highest tumstatin levels in skeletal muscle samples, whereas the lowest levels were observed in the same group, with a significant difference (\(p\) = 0.01, d = 2.11). These findings were also observed in the immunohistochemical results for tumstatin positivity in skeletal muscle cells and bands (A Band and I Band), as presented in Figure 5.  
Figure 3: The plasma concentrations of HDL-C (**A**), LDL-C (**B**), TG (**C**), TC (**D**), and AIP (**E**) are illustrated. HDL-C: high-density lipoprotein cholesterol level, LDL-C: low-density lipoprotein cholesterol level, TG: triglyceride level, TC: total cholesterol level, and AIP: atherogenic index ratio.