# Positron Emission Tomography in Cerebral Amyloid Angiopathy: A Scoping Review
## 2 Materials and Methods
### Literature Search  
A systematic review was conducted of published papers reporting abdominal aortic involvement in patients with FMD, following the Meta-Analyses and Systematic Reviews of Observational Studies (MOOSE) group guidelines [22]. We searched the PubMed and EMBASE databases for studies addressing abdominal aortic status in FMD, from inception to 17 September 2024. We used the following keywords for PubMed: \"(angiopathy, cerebral amyloid [MeSH Terms]) AND (positron emission tomography [MeSH Terms])\". We excluded patients with thoracic aortic dissection and traumatic dissection. In addition, we applied forward and backward citation tracking to improve the results. All studies presenting original data relating to the topic of the review were included. We limited the  
\begin{table}
\begin{tabular}{c c} \hline
**Diagnostic Category** & **Criteria** \\ \hline \multirow{5}{*}{
\begin{tabular}{c} Definite CAA \\ \end{tabular} } & Full post-mortem examination demonstrating the following: \\  & \(\bullet\) & Lobar, cortical, or cortical–subcortical hemorrhage \\  & \(\bullet\) & Severe CAA with vasculopathy \\  & \(\bullet\) & Absence of other diagnostic lesion \\  & & Clinical data and pathologic tissue (evacuated \\ Probable CAA & hematoma or cortical biopsy) demonstrating the following: \\ with supporting & \(\bullet\) & Lobar, cortical, or cortical–subcortical hemorrhage (including ICH and/or CMB) \\ pathology & \(\bullet\) & Some degree of CAA in specimen \\  & \(\bullet\) & Absence of other diagnostic lesion \\  & \(\bullet\) & Clinical data and MRI or CT demonstrating the following: \\  & \(\bullet\) & Multiple hemorrhages (ICH, CMB) restricted to lobar, cortical, or \\  & & cortical–subcortical regions (cerebellar hemorrhage allowed) \\  & & OR \\ Probable CAA & \(\bullet\) & Single lobar, cortical, or cortical–subcortical hemorrhage and cSS (focal or \\  & \(\bullet\) & disseminated) \\  & \(\bullet\) & Age \(\geq\) 55 years \\  & \(\bullet\) & Absence of other cause of hemorrhage or cSS \\  & & Clinical data and MRI or CT demonstrating the following: \\  & \(\bullet\) & Single lobar, cortical, or cortical–subcortical ICH, CMB \\  & & OR \\ Possible CAA & \(\bullet\) & Presence of cSS (focal or disseminated) \\  & \(\bullet\) & Age \(\geq\) 55 years \\  & \(\bullet\) & Absence of other cause of hemorrhage or cSS \\ \hline \end{tabular}
\end{table}
Table 1: CAA diagnostic criteria v. 1.5 [18].  
selection to English studies, and excluded studies on nonhuman subjects and case reports or cases. Abstracts presented at relevant scientific meetings were excluded because of a lack of relevant information. We avoided including duplicated datasets. Two investigators ([PERSON], [PERSON]) independently screened the papers retrieved in the literature search, performing this according to previously detailed criteria, and a third investigator ([PERSON]) was involved to resolve disagreements. The NIH Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies [23] was used to evaluate each eligible publication. The following information was extracted: authors, year of publication, number of patients with possible/probable/definite CAA, and MRI and PET findings. In the case of missing values, we tried to derive them whenever it was possible [23]. Disagreements between the two reviewers were addressed and resolved by consensus.