## 3 Results
### Non-Targeted LC-QTOF-MS Based Metabolomics Data
\begin{table}
\begin{tabular}{c c c c} \hline \hline
**Precursor** & **EC Number** &
\begin{tabular}{c} **Is It Included in** \\ **CannGEM?** \\ \end{tabular} \\ \hline E2 5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase & 2.5.1.54 & Yes \\ \hline ARO1; pentafunctional AROM polypeptide & 4.2.3.4 & Yes \\ \hline aroKB; shikimate kinase/3-dehydroquinate synthase & 2.7.1.71 & Yes \\ \hline K16305; fructose-bisphosphate aldolase/6-deoxy-5-ketofructose 1-phosphate synthase & 4.1.2.13 & Yes \\ \hline K11646; 3-dehydroquinate synthase II & 1.4.1.24 & No \\ \hline aro; 3-dehydroquinate dehydatase I & 4.2.1.10 & Yes \\ \hline QUIB, qa-3; quinate dehydrogenase & 1.1.1.24 & No \\ \hline aroE; shikimate dehydrogenase & 1.1.1.25 & Yes \\ \hline quiA; quinate dehydrorogenase (quinone) & 1.1.5.8 & No \\ \hline ydiB; quinate/shikimate dehydrogenase & 1.1.1.282 & Yes \\ \hline aroK, aroL; shikimate kinase & 2.7.1.71 & Yes \\ \hline aroA; 3-phosphhikimate 1-carboxyvinyltransferase & 2.5.1.19 & Yes \\ \hline K24018; cyclohexarieny/prephenate dehydrogenase/3-phosphhikimate & 1.3.1.43 & No \\ \hline \multirow{2}{*}{aroC; chorismate synthase} & 4.2.3.5 & Yes \\ \cline{2-2}  & TRP3; anthranilate synthase/indole-3-glycerol phosphate synthase & 4.1.3.27 & Yes \\ \hline \multirow{2}{*}{trp; anthranilate phosphoribosyltransferasetransferase} & 2.4.2.18 & Yes \\ \cline{2-2}  & trpF; phosphoribosylanthranilate isomerase & 5.3.1.24 & Yes \\ \hline \multirow{2}{*}{trp; phosphoribosyl isomerase A} & 5.3.1.16 & Yes \\ \cline{2-2}  & trpC; indole-3-glycerol phosphate synthase & 4.1.1.48 & Yes \\ \hline \multirow{2}{*}{trp; tryptophan synthase} & 4.2.1.20 & Yes \\ \cline{2-2}  & E5.4.99.5; chorismate mutase & 5.4.99.5 & Yes \\ \cline{2-2}  & tryA1; chorismate mutase & 5.4.99.5 & Yes \\ \hline \multirow{2}{*}{tyrA; chorismate mutase/prephenate dehydrogenase} & 5.4.99.5 & Yes \\ \cline{2-2}  & pheA1; chorismate mutase & 5.4.99.5 & Yes \\ \hline \multirow{2}{*}{pheA; chorismate mutase/prephenate dehydratase} & 5.4.99.5 & Yes \\ \cline{2-2}  & AROA1, aroA; chorismate mutase & 5.4.99.5 & Yes \\ \hline \multirow{2}{*}{aroH; chorismate mutase} & 5.4.99.5 & Yes \\ \cline{2-2}  & pheB; chorismate mutase & 5.4.99.5 & Yes \\ \hline \multirow{2}{*}{tyrA2; prephenate dehydrogenase} & 1.3.1.12 & No \\ \cline{2-2}  & TYR1; prephenate dehydrogenase (NAP+) & 1.3.1.13 & No \\ \hline \multirow{2}{*}{tyrC; cyclohexadieny/prephenate dehydrogenase} & 1.3.1.43 & No \\ \hline \multirow{2}{*}{tyrA; arogenate dehydrogenase (NAP+)} & 1.3.1.78 & Yes \\ \cline{2-2}  & pheC; cyclohexadienyl dehydatase & 4.2.1.51 & Yes \\ \hline AT, PT; arogenate/prephenate dehydatase & 4.2.1.91 & Yes \\ \hline GOT1; aspartate aminotransferase, cytoplasmic & 2.6.1.1 & Yes \\ \hline TAT; tyrosine aminotransferase & 2.6.1.5 & Yes \\ \hline hisC; histidinol-phosphate aminotransferase & 2.6.1.9 & Yes \\ \hline tyB; aromatic-amino-acid transaminase & 2.6.1.57 & Yes \\ \hline ARO8; aromatic amino acid aminotransferase I/2-aminoadipate transaminase & 2.6.1.57 & Yes \\ \hline ARO9; aromatic amino acid aminotransferase II & 2.6.1.58 & Yes \\ \hline pdh; phenylalanine dehydrogenase & 1.4.1.20 & No \\ \hline IL4 II; L-amino-acid oxidase & 1.4.3.2 & No \\ \hline phhA, PAH; phenylalanine-4-hydroxylase & 1.14.16.1 & No \\ \hline hphA; benzyl malate synthase & 2.3.3.- & No \\ \hline \hline \end{tabular}
\end{table} 
Table 4: \(Cont.\)