## 4 Discussion
\begin{tabular}{c c c c c c c c} \hline \hline  & **Oostell\({}^{\circledR}\)** & **Oostell\({}^{\circledR}\)** & **PENGUIN\({}^{\circledR}\)** & **PENGUIN\({}^{\circledR}\)** & **MegaISQ\({}^{\circledR}\)** & **MegaISQ\({}^{\circledR}\)** & **TOTAL** \\  & **Beacon** & **Beacon** & **Parallel** & **Perpend.** & **Perpend.** & **Perpend.** & & & & \\ \hline OSSTELL\({}^{\circledR}\) & 1 & 0.723 ** & 0.667 ** & 0.555 ** & 0.766 ** & 0.405 ** & 4.12 \\ \hline OSSTELL\({}^{\circledR}\) & 0.723 ** & 1 & 0.575 ** & 0.652 ** & 0.653 ** & 0.525 ** & 4.13 \\ \hline PENGUIN\({}^{\circledR}\) & 0.667 ** & 0.575 ** & 1 & 0.760 ** & 0.691 ** & 0.298 * & 3.99 \\ \hline PENGUIN\({}^{\circledR}\) & 0.555 ** & 0.652 ** & 0.760 ** & 1 & 0.675 ** & 0.404 ** & 4.05 \\ \hline MEGASQ\({}^{\circledR}\) & 0.766 ** & 0.653 ** & 0.691 ** & 0.675 ** & 1 & 0.449 ** & 4.23 \\ \hline MEGASQ\({}^{\circledR}\) & 0.405 ** & 0.525 ** & 0.298 * & 0.404 ** & 0.449 ** & 1 & 3.08 \\ \hline \hline \end{tabular}   
* *value can be interpreted as a correct osseointegration of a failed implant with Penguin(r) or as a failed implant with a correct osseointegration with MegaISQ(r). Comparing the correlation between each instrument, MegaISQ(r) measuring parallel had the higher correlation to the others (considering every instrument and technique). However, the same instrument obtained the lowest correlation when measuring perpendicular (lowest Pearson correlation coefficient and widest difference of agreement with the mean ISQ values in the Bland-Altman plot). On the other hand, Osstell(r) Beacon obtained good correlation for measuring both parallel and perpendicular (and the narrowest difference of agreement with the mean ISQ values), and Penguin(r) had similar correlation values with the other methods measuring parallel and perpendicular. This study has some limitations. The bone density can affect ISQ values [19] and no previous evaluation of the different bone locations where implants were placed was done. However, some aspects that could affect ISQ values, such as implant length and diameter were controlled using the same implant size for all measurements. Another limitation was the manual tightening of the transducers, but this technique was previously reported to be objective and reliable [20]. Finally, it was not possible to blind the investigators within the instrument used, and the study was performed in an animal model. Therefore, further research is needed to clinically assess in vivo the behavior of these devices. The following are available online at [[https://www.mdpi.com/article/10.3390/app11083453/s1](https://www.mdpi.com/article/10.3390/app11083453/s1)]([https://www.mdpi.com/article/10.3390/app11083453/s1](https://www.mdpi.com/article/10.3390/app11083453/s1)), Table S1. Normality and homogeneity of variances. Conceptualization, J.L.-L., R.A.-M. and E.V.-O. ; Methodology, R.A.-M., J.L.-L., [PERSON]-H. and E.V.-O. ; Software, R.A.-M. and C.S.-H.; Validation, M.B.-H., [PERSON]-H., V.D.-A., J.L.-L., R.A.-M. and E.V.-O. ; Formal Analysis, R.A.-M. and [PERSON]-H.; Investigation, V.D.-A., [PERSON]-H., [PERSON] and [PERSON]-[PERSON]; Resources, [PERSON]-M. and [PERSON]-L.; Data Curation, V.D.-A., M.B.-H. and [PERSON]-M.; Writing--Original Draft Preparation, [PERSON]-M. and [PERSON]-L.; Writing--Review and Editing, M.B.-H., [PERSON]-M. and [PERSON]-[PERSON]; Visualization, [PERSON]-M., J.L.-L.; Supervision, [PERSON]-L., [PERSON]-M. and [PERSON]-[PERSON]; Project Administration, [PERSON]-H., [PERSON]-M. and [PERSON]-L. All authors have read and agreed to the published version of the manuscript. This research received funding from Bionhorizons-Camlog(r) Iberica with the grant number 018582/2019, and from the Faculty of Medicine and Health Sciences, University of Barcelona. Data Availability Statement: Data of obtained from this study is not available publicly. Information regarding these data should be requested to the corresponding author. The authors gratefully acknowledge [PERSON] for the statistical analysis support.