###### Abstract  
In the present study, a thorough examination of nanoindentation-based mechanical properties of a refractory MoTaNbVW high-entropy alloy (RHEA) was conducted. Basic mechanical properties, such as the indentation modulus of elasticity, indentation hardness, and indentation-absorbed elastic energy, were assessed by means of different input testing variables, such as the loading speed and indentation depth. The obtained results were discussed in terms of the elasto-plastic behavior of the affected material by the indentation process and material volume. Detailed analysis of the RHEA alloy's nanoindentation creep behavior was also assessed. The effect of testing parameters such as preset indentation depth, loading speed, and holding--at the creep stage--time were selected for their impact. The results were explained in terms of the availability of mobile dislocations to accommodate creep deformation. Crucial parameters, such as maximum shear stress developed during testing (\(\tau_{\text{max}}\)), critical volume for dislocation nucleation (Vcr), and creep deformation stress exponent \(n\), were taken into consideration to explain the observed behavior. Additionally, in all cases of mechanical property examination and in order to identify those input testing parameters--in case--that have the most severe effect, an extensive statistical analysis was conducted using four different methods, namely ANOVA, correlation matrix analysis, Random Forest analysis, and Partial Dependence Plots. It was observed that in most of the cases, the statistical treatment of the obtained testing data was in agreement with the microstructural and metallurgical observations and postulates. ref:fig-entropy alloys (RHEAs); nanoindentation testing; nanoindentation creep; ANOVA analysis; correlation analysis; Random Forest; Partial Dependence Plots 2024 21 March 2024 21 March 2024 22 March 2024 25 March 2 and refractory metal variants, have been extensively explored and evaluated for their diverse physical, chemical, and mechanical characteristics [1]. Among these properties, creep resistance stands out as particularly critical for the performance of both traditional and advanced alloys across numerous industrial applications. Consequently, the study of HEAs' creep behavior has become indispensable. Traditionally, the examination of creep behavior relied heavily on meticulously designed experimental tests, primarily utilizing standard tensile testing equipment, which has been crucial for understanding material performance under extreme conditions. However, the introduction of dynamic indentation techniques for evaluating creep response, among other mechanical attributes, has marked a significant advancement. The benefits of such indentation methods include the simplicity of both the testing process and the required sample size and shape, as well as the reduced duration of experiments. Nonetheless, the complexity of the stress fields induced during indentation necessitates a thorough and accurate analysis of test parameters at both practical and theoretical levels [2; 3]. The pioneering systematic study on the creep behavior of various materials via indentation techniques was conducted by [PERSON] et al. [4]. They identified two distinct zones beneath the indenter: a hydrostatic pressure zone devoid of plasticity, followed by an elastic-plastic zone where plastic deformation and, consequently, creep phenomena could occur. [PERSON] et al. [4] outlined several creep mechanisms, including dislocation glide under high stress in the elastic-plastic region (predominant at lower temperatures), a mixed mode of power law dislocation climb-glide at higher temperatures; a mixed climb-glide mode under conditions of high temperature and stress; and diffusion creep, where stress field differences between zones create chemical potential gradients, facilitating atomic diffusion and material flow.