# Texture-Based Analysis of \({}^{\bf 18}\)F-Labeled Amyloid PET Brain Images
## 4 Discussion  
In this study, image features from 18F-labeled amyloid PET images are evaluated to differentiate between A\(\beta\)+ and A\(\beta-\) cases. The SUVR, commonly used in clinical practice, as well as 6 HFs, which do not require a reference region normalization, are extracted. The quantitative features are compared in three study groups. These correspond to all the patients of the retrospective cohort, those whose amyloid PET images were acquired with [18]FJFBP, and [18]FJFMM PET images. Each HF is evaluated individually whether it can \begin{table}
\begin{tabular}{c c c c c c c c c c c c} \hline \hline
**Image Feature** & \multicolumn{2}{c}{**Frontal**} & \multicolumn{2}{c}{**Occipital**} & \multicolumn{2}{c}{**Parietal**} & \multicolumn{2}{c}{**Temporal**} & \multicolumn{2}{c}{**PCC**} & \multicolumn{2}{c}{**Anterior**} \\  & **L** & **R** & **L** & **R** & **L** & **R** & **L** & **R** & **L** & **R** & **L** & **R** \\ \hline SUVR & **0.772** & **0.768** & **0.705** & 0.698 & **0.717** & **0.745** & **0.747** & **0.775** & **0.787** & **0.768** & **0.788** & **0.720** \\ Energy & 0.671 & **0.730** & **0.880** & **0.837** & 0.584 & 0.479 & **0.722** & **0.738** & 0.659 & **0.811** & 0.541 & **0.767** \\ Contrast & **0.249** & **0.183** & **0.187** & **0.178** & 0.388 & 0.376 & **0.295** & 0.316 & **0.212** & **0.223** & 0.543 & 0.490 \\ Entropy & **0.231** & **0.203** & **0.152** & **0.167** & 0.388 & 0.456 & 0.333 & 0.301 & 0.384 & **0.172** & 0.460 & **0.264** \\ Homogeneity & 0.696 & **0.768** & **0.864** & **0.858** & 0.597 & 0.520 & **0.773** & **0.769** & **0.780** & **0.799** & 0.642 & **0.777** \\ Correlation & 0.588 & 0.685 & 0.626 & 0.560 & 0.545 & 0.589 & **0.758** & 0.671 & 0.624 & 0.529 & 0.449 & **0.260** \\ Dissimilarity & **0.249** & **0.194** & **0.167** & **0.159** & 0.388 & 0.407 & **0.266** & **0.294** & **0.211** & **0.210** & 0.517 & 0.397 \\ \hline \hline \end{tabular}
\end{table} 
Table 7: AUC values from ROC analyses of VOI image features for all patients. AUCs > 0.7 and <0.3 are given in bold. (L, left; R, right; PCC, combined posterior cingulate/precuneus). \begin{table}
\begin{tabular}{c c c c c c c c c c c c} \hline \hline
**Image Feature** & \multicolumn{2}{c}{**Frontal**} & \multicolumn{2}{c}{**Occipital**} & \multicolumn{2}{c}{**Parietal**} & \multicolumn{2}{c}{**Temporal**} & \multicolumn{2}{c}{**PCC**} & \multicolumn{2}{c}{**Anterior**} \\  & **L** & **R** & **L** & **R** & **L** & **R** & **L** & **R** & **L** & **R** & **L** & **R** \\ \hline SUVR & **0.768** & **0.777** & **0.732** & 0.692 & 0.692 & **0.754** & **0.759** & **0.817** & **0.835** & **0.799** & **0.826** & **0.741** \\ Energy & 0.696 & **0.826** & **0.777** & **0.728** & 0.594 & 0.616 & 0.594 & 0.656 & **0.781** & **0.728** & 0.580 & **0.781** \\ Contrast & **0.183** & **0.138** & **0.263** & **0.290** & 0.317 & **0.295** & 0.335 & 0.411 & **0.223** & **0.254** & 0.527 & 0.446 \\ Entropy & **0.161** & **0.125** & **0.246** & **0.259** & 0.362 & 0.353 & 0.460 & 0.442 & **0.196** & **0.259** & 0.420 & **0.205** \\ Homogeneity & **0.732** & **0.848** & **0.786** & **0.781** & 0.616 & 0.634 & 0.687 & 0.696 & **0.754** & **0.714** & 0.674 & **0.844** \\ Correlation & 0.665 & **0.737** & 0.589 & 0.554 & 0.634 & 0.638 & **0.746** & **0.705** & 0.647 & 0.598 & 0.540 & 0.366 \\ Dissimilarity & **0.192** & **0.134** & **0.259** & **0.246** & 0.335 & 0.330 & 0.335 & 0.388 & **0.241** & **0.254** & 0.496 & 0.330 \\ \hline \hline \end{tabular}
\end{table} 
Table 8: AUC values from ROC analyses of VOI image features from [18]FJFBP PET images. AUCs > 0.7 and <0.3 are given in bold. (L, left; R, right; PCC, combined posterior cingulate/precuneus).