## 5 Conclusions  
High-induction magnetic stimulation is an effective form of electrotherapy without the need for galvanic contact with the patients' body, which is based on the effect of electric currents induced in treated tissues through time-varying low-frequency magnetic field. Every biophysical therapeutic method has its limitations, including the HIMS method, such as contraindication, risks, and possible side effects. However, with more research in this field, a considerable amount of new knowledge is being presented, including new contraindications, or on the other hand, some already known contraindications may be proved irrelevant. Some of the contraindications are obvious concerning the presented biophysical therapeutic method, such as a cardiac pacemaker, insulin, and other electronically controlled infusion pumps, implantable neurostimulators, cochlear implant, microchips for the stimulation of _N. vagus_ or intracranially implanted in the central nervous system, any biotic electronically controlled implants or prostheses implanted in the location of patients' body within the range of magnetic field. Except for the above mentioned, it seems possible to also discuss the metal orthopedic and other implants in the location of the magnetic stimulation application. Another contraindication is pregnancy. Due to the development of safety using these devices, it is necessary to consider also direct undesirable effect of such therapeutic methods. Therefore, the primary aim of this paper was to study the impact of HIMS application in the area that might affect the electrical conduction system of a heart in terms of short-term changes in cardiac activity, particularly with the aim of inducing ventricular fibrillation. Although no pathological signs were found in the ECG record by the supervising physician, the results of the presented study show that HIMS might affect the complex variability of heart rhythm. Therefore, regarding the results of the performed nonlinear analysis and the implications of parameters describing variability, it is quite clear that further study of the problem seems to be appropriate. For a deeper insight into this issue, it would be advisable to monitor the long-term effects of HIMS on the electrical conduction system of a heart. To assess the long-term effects of HIMS, it would be necessary to collect records of the cardiac activity of subjects through the Holter system and to perform subsequent analysis of these records. In such a case, it would be possible to formulate conclusions with regard to long-term changes in the HRV complexity, but in our records, where the signals are 3 and 5 min long it, is not possible to formulate such conclusions regardless of the analysis performed. However, as already mentioned, the study was not focused on monitoring long-term changes, but mainly on inducing ventricular fibrillation (which did not occur) and monitoring the acute condition. Another limitation is the relatively low number of monitored subjects, but the study was conducted as a pilot study and serves as a basis for further research. Therefore, for a more in-depth insight into the issue, it would be necessary to extend the sample of measured subjects, possibly to extend the time of observation of measured subjects after the HIMS application or to use more frequencies of HIMS pulses to influence the electrical conduction system of the heart. Conceptualization, J.P., V.S. And M.S. ; data curation, L.H., J.P., V.S. ; formal analysis, L.H. And V.S. ; funding acquisition, J.P., V.S. And M.S. ; investigation, L.H., J.P. And V.S. ; methodology, J.P. And M.S. ; project administration, J.P. And V.S. ; resources, L.H., J.P., V.S., M.S. And S.V.d.B. ; supervision, J.P.; validation, L.H., V.S. ; visualization, L.H., V.S. ; writing--original draft, L.H., V.S., S.V.d.B; writing--review and editing, L.H., J.P., V.S. M.S. And S.V.d.B. All authors have read and agreed to the published version of the manuscript. This research was funded by Czech Health Research Council within the project no.