## 3 Experimental Section
### Synthesis
#### 3.2.5 General Procedure for Thioether **(5)**  
A CEM designed 10 mL pressure-rated vial was charged with DMF (5 mL), **4** (1 mmol), RCH2 Cl (1.1 mmol) and NaOH (1.2 mmol). The mixture was irradiated in a CEM Discover Focused Synthesizer (150 W, 90 \({}^{\circ}\)C, 200 psi, 15 min). The mixture was cooled to room temperature by passing compressedair through the microwave cavity for 2 min. It was poured into cold ice (40 mL) and the formed precipitate was filtered. The crude solid was recrystallized from EtOH to give the title compounds **5a**. All the other compounds are synthesized according to the procedure (Scheme 1). 3-(butylthio)-5-((4-chlorophenylophenoxyoxy)methyl)-4-phenyl-4_H_-1,2,4-triazole **5a** yield 87%, m.p. 140-141 \({}^{\circ}\)C; \({}^{1}\)H-NMR (DMSO-\(d_{6}\), 400 MHz), \(\delta\): 0.85 (t, 3H, CH\({}_{3}\)), 1.34 (q, 2H, CH\({}_{2}\)), 1.62 (m, 2H, CH\({}_{2}\)), 3.12 (m, 2H, CH\({}_{2}\)), 3.12 (t, 2H, SCH\({}_{2}\)), 5.09 (s, 2H, OCH\({}_{2}\)), 6.90 (d, \(J\) = 8.2 Hz, 2H, Ph), 7.27 (d, \(J\) = 8.2 Hz, 2H, Ph), 7.45-7.55 (m, 5H, Ar-H). ESI-MS: 375 [M + H]\({}^{+}\); Elemental analysis for C\({}_{19}\)H\({}_{20}\)ClN\({}_{3}\)OS: found C 60.98, H 5.56, N 11.43; calcd. C, 61.03; H, 5.39; N, 11.24. 3-(benzylthio)-5-((4-chlorophenylophenoxyoxy)methyl)-4-phenyl-4_H_-1,2,4-triazole **5b** yield 81%, m.p. 104-105 \({}^{\circ}\)C; \({}^{1}\)H-NMR (DMSO-\(d_{6}\), 400 MHz), \(\delta\): 4.38 (s, 2H, SCH\({}_{2}\)), 5.08 (s, 2H, OCH\({}_{2}\)), 6.87 (d, \(J\) = 8.0 Hz, 2H, Ph), 7.27-7.20 (m, 8H, Ph), 7.51 (m, 4H, Ph). ESI-MS: 409 [M + H]\({}^{+}\); Elemental analysis for C\({}_{22}\)H\({}_{18}\)ClN\({}_{3}\)OS: found C 64.44, H 4.53, N 10.98; calcd. C, 64.78; H, 4.45; N, 10.30. 3-((4-chlorobenzyl)thio)-5-((4-chlorophenylophenoxyoxy)methyl)-4-phenyl-4_H_-1,2,4-triazole **5c** yield 77%, m.p. 108-109 \({}^{\circ}\)C; \({}^{1}\)H-NMR (DMSO-\(d_{6}\), 400 MHz), \(\delta\): 4.38 (s, 2H, SCH\({}_{2}\)), 5.09 (s, 2H, OCH\({}_{2}\)), 6.88 (d, \(J\) = 8.2 Hz, 2H, Ph), 7.05-7.19 (m, 2H, Ph), 7.27-7.37 (m, 6H, Ph), 7.50-7.52 (m, 3H, Ph). ESI-MS: 443 [M + H]\({}^{+}\); Elemental analysis for C\({}_{22}\)H\({}_{17}\)Cl\({}_{2}\)N\({}_{3}\)OS: found C 59.83, H 3.97, N 9.45; calcd. C, 59.73; H, 3.87; N, 9.50. 3-((4-bromobenzyl)thio)-5-((4-chlorophenylophenoxyoxy)methyl)-4-phenyl-4_H_-1,2,4-triazole **5d** yield 68%, m.p. 99-100 \({}^{\circ}\)C; \({}^{1}\)H-NMR (DMSO-\(d_{6}\), 400 MHz), \(\delta\): 4.35 (s, 2H, SCH\({}_{2}\)), 5.08 (s, 2H, OCH\({}_{2}\)), 6.88 (d, \(J\) = 8.2 Hz, 2H, Ph), 7.27-7.33 (m, 6H, Ph), 7.45-7.52 (m, 6H, Ph). ESI-MS: 488 [M + H]\({}^{+}\); Elemental analysis for C\({}_{22}\)H\({}_{17}\)BrClN\({}_{3}\)OS: found C 53.97, H 3.31, N 8.99; calcd. C, 54.28; H, 3.52; N, 8.63. 3-((2-chlorobenzyl)thio)-5-((4-chlorophenylophenoxyoxy)methyl)-4-phenyl-4_H_-1,2,4-triazole **5e** yield 77%, m.p. 108-109 \({}^{\circ}\)C; \({}^{1}\)H-NMR (DMSO-\(d_{6}\), 400 MHz), \(\delta\): 4.44 (s, 2H, SCH\({}_{2}\)), 5.09 (s, 2H, OCH\({}_{2}\)), 6.88 (d, \(J\) = 8.2 Hz, 2H, Ph), 7.08-7.19 (m, 2H, Ph), 7.27-7.39 (m, 6H, Ph), 7.50-7.52 (m, 3H, Ph). ESI-MS: 443 [M + H]\({}^{+}\); Elemental analysis for C\({}_{22}\)H\({}_{17}\)Cl\({}_{2}\)N\({}_{3}\)OS: found C 59.63, H 3.97, N 9.45; calcd. C, 59.73; H, 3.87; N, 9.50. 3-((4-chlorophenylophenoxyoxy)methyl)-5-((4-methoxybenzyl)thio)-4-phenyl-4_H_-1,2,4-triazole **5f** yield 82%, m.p. 122-123 \({}^{\circ}\)C; \({}^{1}\)H-NMR (DMSO-\(d_{6}\), 400 MHz), \(\delta\): 3.72 (s, 3H, OCH\({}_{3}\)), 4.33 (s, 2H, SCH\({}_{2}\)), 5.09 (s, 2H, OCH\({}_{2}\)), 6.82 (d, \(J\) = 6.8 Hz, 2H, Ph), 6.88 (d, \(J\) = 6.8 Hz, 2H, Ph), 6.88 (d, \(J\) = 6.8 Hz, 2H, Ph), 7.21-7.33 (m, 3H, Ph), 7.46-7.58 (m, 5H, Ph). ESI-MS: 478 [M + H]\({}^{+}\); Elemental analysis for C\({}_{22}\)H\({}_{16}\)Cl\({}_{3}\)N\({}_{3}\)OS: found C 55.22, H 3.07, N 8.51; calcd. C, 55.42; H, 3.38; N, 8.81. 4-(((5-(4-chlorophenylophenoxyoxy)methyl)-4-phenyl-4_H_-1,2,4-triazole0-3-yl)thio)methyl)benzonitrile **5h** yield 79%, m.p.