## 5 Antioxidants from Natural Products as Alternative Treatment
### Gingerol  
Gingerol, a bioactive compound found in ginger (_Zingiber officinal_), possesses notable antioxidant properties that make it a promising candidate for managing psoriasis symptoms. By neutralizing harmful free radicals in the body, gingerol effectively combats oxidative stress, potentially alleviating the manifestations of psoriasis. Research by [PERSON] et al. (2022) highlights the pivotal role of oxidative stress in initiating inflammatory pathways such as MAPK, NF-k\(\beta\), and JAK-STAT, which subsequently activate immune cells and induce cytokine production, notably TNF-\(\alpha\) and IL-17. Ginger's ability to suppress NF-k\(\beta\) and reduce cytokine expression underscores its potential as an alternative therapy for psoriasis, particularly given the heightened expression of NF-k\(\beta\) in psoriatic lesions [81]. The study demonstrates that ginger therapy reduced MDA levels in both erythrocytes and lymphocytes to levels that were even lower than those observed in healthy controls and enhanced the TAS over a period of 60 days, indicating a time-dependent improvement in antioxidant capacity, which may offer therapeutic advantages for controlling oxidative stress [82]. The antioxidant molecule [6]-gingerol, found abundantly in soil ginger, demonstrated antioxidant properties by enhancing CAT activity and decreasing MDA levels in Sprague Dawley rats of various ages [83]. The findings indicate that soil ginger has potential as a nutraceuticaltial for attenuating oxidative stress.  
Practically, individuals with psoriasis may find relief through the use of topical therapies containing ginger or by incorporating gingerol-rich dietary supplements or extracts into their regimen. In research by [PERSON] et al., the encapsulation of metformin and ginger in lipid-based nanoparticles showed promising results in treating psoriasis. Results showed that co-administration of metformin and ginger-loaded liposomes effectively treated psoriatic lesions, significantly reducing inflammatory markers like IL-22 and TNF-\(\alpha\)[9]. This study emphasizes the potential of ginger as a supplementary treatment for controlling psoriasis, evidenced by its beneficial impact on the advancement of the illness through the regulation of inflammatory pathways. Moreover, the bioavailability and efficacy of gingerol can be further improved by using novel delivery methods such as nano-encapsulation. These systems safeguard the active chemicals from degradation and allow for precise distribution to the specific tissues that are impacted. Whether applied topically or consumed as a dietary supplement, gingerol offers hope for individuals seeking relief from psoriasis symptoms, although continued research is necessary to fully understand its mechanisms of action.  
Despite promising evidence, further investigation is warranted to elucidate the precise mechanisms underlying gingerol's therapeutic effects in psoriasis. A comprehensive understanding of how gingerol interacts with molecular pathways involved in psoriasis pathogenesis could provide valuable insights into its therapeutic potential and optimize its use in psoriasis management. In conclusion, gingerol, a potent antioxidant compound found in ginger, holds promise as a natural remedy for alleviating the symptoms of psoriasis. Its promise as an alternative treatment for psoriasis management is suggested by its capacity to reduce inflammatory pathways, including NF-k\(\beta\), and fight oxidative stress.