# Fibroblast-Specific Protein Interactions for Myocardial Fibrosis from MetaCore Network
## 2 Data Sets and INFI Model Description
### Network Data Sets
\begin{table}
\begin{tabular}{c c c c c} \hline \hline \(K_{g}\) & \(K_{t,u,d,x}\) & \(K\) & \(K^{*}\) & **Protein** \\ \hline
1 & \(K_{t}=1\) & 10,780 & 26,299 & TCF-\(\beta\) 0 \\
2 & \(K_{t}=2\) & 235 & 5690 & TGF-\(\beta\) 1 \\
3 & \(K_{t}=3\) & 968 & 25,073 & TGF-\(\beta\) 2 \\
4 & \(K_{t}=4\) & 4726 & 29,508 & TGF-\(\beta\) 3 \\
5 & \(K_{t}=1\) & 28,737 & 25,928 & ADAMTS16 \\
6 & \(K_{t}=2\) & 3478 & 25,137 & FGF21 \\
7 & \(K_{u}=3\) & 40,048 & 28,152 & TNSF81 \\
8 & \(K_{u}=4\) & 2467 & 19,160 & ACAN \\
9 & \(K_{u}=5\) & 1489 & 24,511 & RPH3A \\
10 & \(K_{u}=6\) & 26,600 & 29,559 & ADAMTS8 \\
11 & \(K_{u}=7\) & 34,769 & 39,960 & MEGF6 \\
12 & \(K_{u}=8\) & 26,295 & 27,326 & SV2B \\
13 & \(K_{u}=9\) & 27,111 & 36,021 & C1 QTNF3 \\
14 & \(K_{u}=10\) & 34,616 & 39,841 & ANO4 \\
15 & \(K_{u}=11\) & 12,696 & 16,566 & IL11 \\
16 & \(K_{u}=12\) & 26,624 & 23,640 & CDH10 \\
17 & \(K_{u}=13\) & 7263 & 30,243 & HTR2B \\
18 & \(K_{u}=14\) & 4647 & 6551 & LAMA1-1 \\
19 & \(K_{u}=15\) & 8342 & 26,295 & LAMA1-2 \\
20 & \(K_{u}=16\) & 4021 & 8252 & RARGET4 \\
21 & \(K_{u}=17\) & 29,945 & 36,964 & DNER \\
22 & \(K_{u}=18\) & 22,159 & 8569 & GALNT3 \\
23 & \(K_{u}=19\) & 29,145 & 15,531 & ACSB61 \\
24 & \(K_{u}=20\) & 24,786 & 8735 & OLFM2 \\
25 & \(K_{d}=1\) & 19,039 & 28,262 & CLEC3B \\
26 & \(K_{d}=2\) & 26,477 & 28,290 & SCARA5 \\
27 & \(K_{d}=3\) & 26,109 & 11,185 & SLC10A6 \\
28 & \(K_{d}=4\) & 6360 & 29,204 & CXCL5 \\
29 & \(K_{d}=5\) & 14,952 & 8729 & MYOC \\
30 & \(K_{d}=6\) & 5961 & 22,288 & IFITM1 \\
31 & \(K_{d}=7\) & 5599 & 4483 & ANGPTL4 \\
32 & \(K_{d}=8\) & 25,538 & 17,434 & SELENBP1 \\
33 & \(K_{d}=9\) & 18,938 & 33,179 & FMO1 \\
34 & \(K_{d}=10\) & 34,008 & 39,427 & GPR88 \\
35 & \(K_{d}=11\) & 6276 & 22,141 & HMG52 \\
36 & \(K_{d}=12\) & 37,060 & 28,328 & LG12 \\
37 & \(K_{d}=13\) & 9162 & 2485 & PTN \\
38 & \(K_{d}=14\) & 513 & 5974 & ADORA2A \\
39 & \(K_{d}=15\) & 7789 & 22,652 & GFRA1 \\
40 & \(K_{d}=16\) & 6718 & 8844 & IL1R2-1 \\
41 & \(K_{d}=17\) & 35,446 & 28,306 & IL1R2-2 \\
42 & \(K_{d}=18\) & 12,148 & 3444 & PEG10 \\
43 & \(K_{d}=19\) & 27,829 & 36,195 & FMO2 \\
44 & \(K_{d}=20\) & 1973 & 24,994 & COX412 \\
45 & \(K_{x}=1\) & 3 & 13 & \(\beta\)-catenin \\
46 & \(K_{x}=2\) & 4 & 6 & p53 \\
47 & \(K_{x}=3\) & 11 & 10 & ESR1 \\
48 & \(K_{x}=4\) & 13 & 25 & STAT3 \\
49 & \(K_{x}=5\) & 22 & 11 & RelA \\
50 & \(K_{x}=6\) & 38 & 82 & PPAR-\(\gamma\) \\
51 & \(K_{x}=7\) & 111 & 767 & IK\(\beta\) \\
52 & \(K_{x}=8\) & 179 & 198 & SNAIL1 \\
53 & \(K_{x}=9\) & 237 & 1520 & MMP-14 \\
54 & \(K_{x}=10\) & 578 & 2123 & Flotillin-1 \\ \hline \hline \end{tabular}
\end{table} 
Table 1: Table of the subset of \(N_{r}=54\) selected fibrosis proteins (nodes). Here \(K_{g}\) represents the global index of this group, \(K_{t,u,d,x}\) represent the index of the four subgroups of 4 TGF-\(\beta\) proteins, 20 up-proteins, 20 down-proteins and 10 additional X-proteins; the \(K\) (\(K^{*}\)) index represents the PageRank (CheiRank) index for the global MetaCore network of \(N=40\),079 nodes; the last column gives the associated protein names.