Several comparative studies have demonstrated the excellent performances, in terms of recovery and precision, obtainable with MAE compared to other traditional extraction techniques (for example extraction with Soxhlet) and its superiority in terms of reduction of solvent consumption and extraction time [7; 8]. For example, conventional Soxhlet extraction usually requires long extraction times leading also to thermal degradation of phytoconstituents. During MAE process, the internal pressure of the sample is increased by microwaves in a few minutes with the effect of enhanced extraction efficiency and reduce the deterioration of phenolic compounds [9]. The post-extraction analytical characterization was performed by ATR- FTIR and HPLC, above all to identify the main phenolic compounds, especially quercetin and kaempfer, notoriously characteristic of this plant species [10]. These tandem processing procedures led to evaluate the dependence of phenolic content with respect to both the harvesting time and Aglianico and Greco di Tufo varieties. The obtained phyto-extracts can be used in fluid form to functionalize healthy products having a liquid phase such as hydrogels, topical emulsions [11] and liquid oral dosage forms (i.e., elixirs, syrups or poisons). Additionally, they can be commonly transformed into dry extracts via various technological approaches such as evaporation, lyophilization or spray drying because of their physical, chemical, and microbiological stability, better standardization, higher concentration of active ingredients and compounds. In all the cases, the process of extracts treatment should aim at obtaining a product which attends market requirements as well as provide efficacy, safety, and quality. The removal of solvents by evaporation leads to obtain a sticky dry extract that is difficult both to recover from evaporator flasks and incorporate into dosage forms. On the other hand, the lyophilization is particularly expensive tool, also producing a highly hygroscopic powder that must be stored under controlled temperature and humidity conditions; it provides special storage containers and does not guarantee the stability of the product after opening [12]. In the pharmaceutical industry, the use of suitable technological adjuvants along with the technology of spray drying represents an important step in the assurance of adequate stability and quality of plant extracts [13]. Natural extracts present critical physical and organoleptic characteristics that are not compatible with food, food supplements, cosmetics, or health products in general [14; 15]. The incorporation of these dry extracts in spry-dried formulations is recommended because they are easily obtained, standardized, industrially scalable and embeddable in dosage forms. The spray drying technique is a one-step processing operation for turning a liquid feed into a powder product and it can be used as a microencapsulation tool by introducing into the liquid feed, particular carriers as loading/coating agents [16; 17]. Common carriers for this encapsulation process include carbohydrates, gums, and cellulose esters. Combinations of carriers are also used to provide stability and high technological characteristics (i.e., size, flowability, water up-take) to particular feed materials such as herbal natural extracts [18; 19]. In a previous work, a combination of maltodext (M) and pectins (P), was developed as a tandem-polymeric matrix by spray-drying to encapsulate dried herbal extracts [15]. The excellent obtained results led us to apply the same approach to wine leaves extract (Aglianico variety) with the aim to enhance both the usability and stability also verifying the versatility of the spry drying microencapsulation process. The obtained powder was characterized in term of chemical-physical and enhanced technological characteristics. Results report the feasibility of a transformation process within a production flow-chart from the recovery, through the extraction, to the final product.