# Exploring the Potential of Sensing for Breast Cancer Detection
## 5 Biosensors for Breast Cancer Detection
### Microfluidic Chip  
Fluid can flow in two different ways, viz., laminar flow and turbulent flow. In laminar flow, the streams are parallel [124]. So, there is no mixing between the streams. Then there is turbulent flow, where various inertial forces cause the fluids to move randomly. Turbulent flows tend to affect reading accuracy [124]. In the micrometer regime, the liquid flow is to be considered as laminar flow. So, a complex pattern is produced by the joining points of two fluid streams in a microchannel, and diffusion is required to explain this. On the other hand, the scaling law is a comprehensive way of describing the variation in the physical quantity as a function of the size of the system [124]. Microfluidics is a study associated with submicron fluidic structures, and this knowledge is applied to developing lab-on-chip or microfluidic chip technology [124], which combines different operations. All kinds of operations are completed in a micron-sized chip. Microfluidic chips use semiconductor-like micro-electromechanical processing technology to build a microfluidic system on the chip [124]. Different interconnected paths and liquid phase chambers exist in the chip, and the analysis process associated with the experiment is printed over the chip [124]. Biological samples with their solutions have been loaded, and different pumps and forms of electro-osmotic flow have been used to transmit the flow of the buffer in the chip to form a micro flow path. So, the flow experiences several successive reactions over the traveling trajectory. For accurate and precise sample analysis, different detection systems, along with analysis methods, have been employed in microfluidic chips [124]. A complete microfluidic system includes many components, mainly micr-pumps, microchips, microvalves, and detection units. A micropump is the power source for microfluidic transportation [124]. Microchips can also be classified according to different dimensions and according to the material of the chip. They can be divided into silicon, glass, organic polymer materials, and paper materials [124]. Based on the types of channel arrays, they are single-channel and multi-channel chips. According to the network shape, they can be divided into linear, spiral, curved snake, polygon, folded, etc. Figure 4: Experimental setup of flow cytometry [121]. In microfluidic technology, a small chip can integrate several steps associated with miniaturing and automation. There is high throughput since microfluidics can be designed as multiple channels, and multiple items can be tested in parallel on the same sample as needed. The detection time is significantly shortened, the efficiency is improved, and high-throughput detection is realized. The reaction unit cavity associated with the microfluidic chip is tiny. The reagent usage is far lower than that of conventional methods, and thus, the consumption of reagents is greatly reduced. The demand for sample sizes is small. Since the task is completed on a small chip, the sample size required to be tested is very small, so microliters or even nanoscale amounts could be enough [124]. Biological analysis based on microfluidics includes microfluidic-based analysis in cell mode and microfluidic-based exosome separation analysis [125]. Clinical diagnostic research based on microfluidics includes pathogen detection and analysis based on microfluidics. Cancer detection and analysis can be based on microfluidics. Food safety analysis, including detecting pesticide residuals, pathogenic bacteria, heavy metals, and food additives, has been based on microfluidics [126]. Environmental monitoring and analysis have been based on microfluidics detection methods including electrochemical, optical, and MS methods. Creative Boliols is a leading customer service provider in cancer next-generation sequencing with a professional platform and rich experience.