## 1 Introduction
In our previous work [10], we developed SCO\({}_{2}\) extracts in laboratory scale, starting from raspberry, blueberry, wild strawberry, pomegranate, blackberry, and blackcurrant waste from Rigoni di Asiago. Certified organic biomasses were selected to guarantee the quality of the material and ensure absence of contaminants admitted in conventional agriculture, such as pesticides. We evaluated the qualitative and quantitative phytochemical composition of the obtained SCO\({}_{2}\) extracts, focusing on fatty acids profile, and the results showed the oil extracted from the waste (peel and seeds) of wild strawberries as the most promising for future industrial applications, due to the high extraction yields and the high amount of polyunsaturated fatty acids (PUFAs) obtained in the preliminary prototypes [10]. Wild strawberry or alpine strawberry (_Fragaria vesca_ L.) is a perennial herbaceous plant of the rose family that grows naturally throughout northern Europe and that producesedible fruits. Wild strawberry fruit is flavored, collected, and grown for domestic use and for the industrial production of jam and liquors [13]. Wild strawberry fruits contain monosaccharides, vitamins (C, B1, B2, K), and organic acids (malic, citric, and salicylic) and are a rich source of macro- and micronutrients (calcium, potassium, phosphorus, iron, magnesium, and manganese) [14]. Seeds are part of the residual biomass of wild strawberry fruits' processing waste and contain about 20% of fatty fraction rich in PUFAs, with a low n-6/n-3 fatty acids ratio, which supports the valuable characteristics of wild strawberry seeds oils [15]. PUFAs are essential macronutrients that are attracting attention as potential agents for maintenance of skin health and treatment of skin disorders, particularly those mediated by solar ultraviolet radiation (UVR), including sunburn, cancer, photosensitivity, and photoaging [16]. Furthermore, long-chain PUFAs exhibit potential in diminishing inflammatory processes, which could be beneficial for the management of inflammatory skin diseases, such as atopic dermatitis, psoriasis, and acne [17]. As a source of major lipid components of the stratum corneum, the obtained wild strawberry waste extract could be used as a valuable moisturizing agent for cosmetics products, especially as an embilient, and to repair the moisture barrier of the skin [17]. Indeed, linoleic acid (C18:2) contributes to the composition of ceramides that are crucial for the structure of epidermal barriers, prevent trans-epidermal water loss, and protect from environmental factors and barrier permeability problems [18]. PUFAs are also metabolized to octadecanoids, eicosanoids, docosanoids, endocannabinoids, and related bioactive lipid species, known to mediate inflammatory and immune reactions in many tissues, including skin [19]. It is also reported in the literature that unsaturated fatty acids can inhibit 5\(\alpha\)-reductase, a fundamental enzyme in androgens pathway. After birth, 5\(\alpha\)-reductase type 1 is expressed in more tissues, including the liver, the skin, the scalp, and the prostate, while 5\(\alpha\)-reductase type 2 is expressed in prostate, seminal vesicles, epididymis, liver, and, to a lesser extent, in scalp and skin [20; 21]. The biological function of 5\(\alpha\)-reductase is the irreversible reduction in testosterone to more potent dihydrotestosterone (DHT) [22]. An overexpression of 5\(\alpha\)-reductase enhances cellular DHT and may cause androgen-dependent disorders, including androgenic alopecia, hair loss, hirsutism, and acne [23; 24]. A large number of treatments have been tested for these diseases, including pharmacological 5\(\alpha\)-reductase inhibitors like finasteride and Mutasteride [25; 26]. However, the use of these drugs may imply common adverse effects, such as sexual dysfunction, infertility, mood disorders, gynecomastia, and raised cardiovascular morbidity/risk factors [27; 28] that are less acceptable in case of skin or hair disorders compared to more serious pathological conditions.