## 1 Introduction  
In recent years, the insertion of dental implants as a substitute for absent teeth has evolved into a widespread procedure, encompassing even those patients afflicted with periodontal disease [1; 2]. Oxidative stress occurs when there is a disproportion between the generation of reactive oxygen species (ROS) and the body's antioxidant mechanisms' ability to neutralize these ROS. The latter include free radicals that can damage the cells and tissues [2; 3; 4; 5; 6; 7; 8; 9]. Periodontitis, a chronic inflammatory disorder, is distinguished by symptoms in the oral cavity and substantial systemic effects. This condition significantly influences the support tissues within the mouth. Factors contributing to periodontitis include inadequate dental hygiene, smoking, the oral microbiota's composition, and an individual's genetic susceptibility. A pivotal aspect in the progression of periodontitis is oxidative damage to tissues, which is crucial in the disease's advancement [2; 3; 4; 5; 6; 7; 8; 9]The analysis of salivary biomarkers of oxidative stress has been applied to the diagnosis of various diseases of the oral cavity, as they may be involved in the occurrence and/or development of periodontitis, caries, potentially malignant oral diseases, cancer, inflammation, and fungal diseases [10]. Salivary oxidative stress biomarkers have become a tool for analyzing the pathogenesis and conducting follow-up of oral disorders, and their correct analysis could, in future, lead to individualized diagnosis and treatment for each patient, since their determination is noninvasive, simple, safe, rapid, and painless [11; 12]. The study of saliva is an easy and reproducible method for determining salivary oxidant activity and antioxidant capacity [11]. Periodontitis is characterized by an increase in ROS at the periodontal level, resulting in oxidant imbalance [13; 14; 15; 16]. [PERSON] et al. [9] observed notable changes in the biochemical markers of patients with periodontitis. Their study indicated a marked reduction in the overall antioxidant capacity. Concurrently, there was an observable elevation in several compounds: malondialdehydedehyde (MDA), nitric oxide, total oxidant status (TOS), and 8-hydroxydeoxyguanosine, all of which were measured in the saliva of these patients. Conventional periodontal treatment exerts beneficial effects upon the antioxidant marker levels; in this regard, several studies have found nonsurgical treatment to significantly modify the MDA concentrations to levels comparable to those observed in periodonontally healthy individuals [17]. It is important that patients with a history of periodontitis who are considering dental implant rehabilitation receive complete and comprehensive information. Factors such as oxidative stress and chronic inflammation are known to have the potential to trigger complications, including peri-implantits [18; 19; 20; 21; 22]. There are data suggesting an increased risk of peri-implantitis in people with periodontitis. This risk is exacerbated by inadequate management of dental plaque control and the absence of regular checkups after implant placement [21; 22; 23]. A study conducted by [PERSON] et al. [23] highlighted that the presence of periodontal disease increases the likelihood of peri-implantits. Following this, [PERSON] et al. [24] investigated the role of periodontitis in the development of peri-implantitis. Their findings revealed a markedly increased risk (odds ratio [OR] 0.23, 95% confidence interval [95%CI] 0.11-0.46) of peri-implantitis. Implant biocompatibility has been studied; in this regard, titanium (Ti) is the predominant material of choice in the field. Damage to the TiO\({}_{2}\) surface layer of dental implants can give rise to corrosion, thereby producing an inflammatory reaction. This in turn results in loss of osseointegration, peri-implantitis, and damage and/or contamination of the peri-implant tissues [8; 17]. There is controversy about the role that ROS may play in osseointegrations [8; 21].