## 1 Introduction  
Medical device items based on polymers, metals, and ceramics are used for a variety of purposes, from diagnostic to therapeutic medical procedures. The use of nanocomposites in the medical field by application of nanotechnology reformed current medicine offering new opportunities to design products for different applications. Thus, a distinctive class of nanocomposites is based on natural and synthetic polymers as matrix combined with a nanofiller with mineral, organic, or metallic origins. The interactions between components provide important characteristics that certify the use of nanocomposites into medical devices [1]. Recently, the interest for poly(lactic acid) (PLA), a biodegradable aliphatic polyester, as a sustainable alternative for biomedical applications has been increased. Its favorable properties, such as biocompatibility, good mechanical strength, and stability with respect to tissues, cells, enzymes, and various body fluids recommend it as one of the most important available biopolymer [2; 3; 4]. However, this biomaterial shows some barrier for medical areas related to its high rigidity, low toughness, and ductility. To overcome such weakness, PLA has been mixed with ecological plasticizers, such as polyethylene glycol (PEG) [5], acetyl tributyl citrate (ATBC) [6; 7], and combination of ATBC and LAPOL 108 [8]. By introduction of nanofillers, such as ZnO nanoparticles [9], vinyl POSS (vinyl 50 polyhedral oligomeric silsequioxane) nanoparticles [10], carbon nanotubes [11], and nano-clay [12], into PLA matrix another useful feature like antimicrobial and UV-light screening properties are obtained. The use of PLA in material engineering is slowing down due to the bacterial adhesion [13]. To overcome these disadvantages, the usage of PLA coated with collagen, a synthetic tetracycline and minocycline (MH), and citrate-hydroxyapatite nanoparticles (cHA) was reported [13]. In another paper, [PERSON] et al. [14] developed biocompatible and antimicrobial composites by use of chitosan into PLA. In [15], the authors immobilized glucosamine/chondroitin sulfate onto the PLA surface to obtain antibacterial PLA films bactericidal with increased cell viability. Natural polymers such as chitosan, starch, collagen, and cellulose have presented a great interest, due to their biocompatibility and non-toxic properties. Also, it has been observed that natural polymers can favor cell attachment and proliferation, while synthetic polymers offer stability of the scaffolds [16]. Collagen is one of the most used natural polymers widely used for scaffold compositions being responsible for cell growth and cell penetration into the engineered matrix, as a biomimetic substitute of the skin. Collagen coated with poly(3-hydroxybytric acid)-gelatin nanofibrous scaffold provides a soft bio-mimetic material for skin tissue engineering applications [17]. [PERSON] et al. suggested the introduction of lignin into PLA to facilitate the control of oxidative stress caused by PLA formulations [18]. Silver is well recognized since antiquity for its antimicrobial activity against bacteria, fungi, and virus, nanotechnology being considered one of the most promising strategies to control microbial biofilms. On a large scale it is used as an ecological alternative for organic biocides and synthetic polymers. [19; 20]. It was reported that the antibacterial activity of silver nanoparticles (AgNPs) is determined by their concentration, size, and shape [21]. High concentration of AgNPs led to both effective antimicrobial activity but potential toxicity in human health. Several alginate based nanocomposite films such as silver zeolite, silver nitrate, metallic silver, and citrate reduced AgNPs, and laser-ablated AgNPs were developed in order to apply these materials into medicine and food industry [22].