# Performance Qualification of Automatic System for Antineoplastic Preparation
## 2 Materials and Methods
### Compounding and Formulation System
\begin{table}
\begin{tabular}{c c c c c c c} \hline \hline  & \multicolumn{6}{c}{**Paclitaxel**} \\ \hline  & \multicolumn{2}{c}{**DRUG**} & \multicolumn{2}{c}{**Diluent**} & \multicolumn{2}{c}{**Total**} & \multirow{2}{*}{**Bag Name**} & \multicolumn{2}{c}{**Theoretical**} \\  & & & **(NaCl 0.9\%)** & & & \\ \hline \multirow{6}{*}{\begin{tabular}{c} RUN\({}^{\circ}\) 1 \\ (High dosage) \\ \end{tabular} } & Paclitaxel 1 & 350 mg & 58.33 mL & 441.67 mL & 500 mL & Run1\_1 & 0.7 mg/mL \\  & Paclitaxel 2 & 350 mg & 58.33 mL & 441.67 mL & 500 mL & Run1\_2 & 0.7 mg/mL \\  & Paclitaxel 3 & 350 mg & 58.33 mL & 441.67 mL & 500 mL & Run1\_3 & 0.7 mg/mL \\  & Paclitaxel 4 & 350 mg & 58.33 mL & 441.67 mL & 500 mL & Run1\_5 & 0.7 mg/mL \\ \hline \multirow{6}{*}{\
\begin{tabular}{c} RUN\({}^{\circ}\) 2 \\ (Low dosage) \\ \end{tabular} } & Paclitaxel 1 & 75 mg & 12.5 mL & 237.5 mL & 250 mL & Run2\_1 & 0.3 mg/mL \\  & Paclitaxel 2 & 75 mg & 12.5 mL & 237.5 mL & 250 mL & Run2\_2 & 0.3 mg/mL \\  & Paclitaxel 3 & 75 mg & 12.5 mL & 237.5 mL & 250 mL & Run2\_3 & 0.3 mg/mL \\  & Paclitaxel 4 & 75 mg & 12.5 mL & 237.5 mL & 250 mL & Run2\_4 & 0.3 mg/mL \\  & Paclitaxel 5 & 75 mg & 12.5 mL & 237.5 mL & 250 mL & Run2\_5 & 0.3 mg/mL \\ \hline \multirow{6}{*}{
\begin{tabular}{c} RUN\({}^{\circ}\) 3 \\ (Random dosage) \\ \end{tabular} } & Paclitaxel 1 & 75 mg & 12.5 mL & 237.5 mL & 250 mL & Run3\_1 & 0.3 mg/mL \\  & Paclitaxel 2 & 100 mg & 16.66 mL & 233.34 mL & 250 mL & Run3\_2 & 0.4 mg/mL \\ \cline{1-1}  & Paclitaxel 3 & 150 mg & 25 mL & 475 mL & 500 mL & Run3\_3 & 0.3 mg/mL \\ \cline{1-1}  & Paclitaxel 4 & 200 mg & 33.33 mL & 466.67 mL & 500 mL & Run3\_4 & 0.4 mg/mL \\ \cline{1-1}  & Paclitaxel 5 & 270 mg & 45 mL & 455 mL & 500 mL & Run3\_5 & 0.54 mg/mL \\ \hline \hline \end{tabular}
\end{table} 
Table 2: Recipe for preparation of infusion bags at different concentrations for the paclitaxel drug. \begin{table}
\begin{tabular}{c c c c c c c} \hline \hline  & \multicolumn{6}{c}{**Cyclophosphamideamide**} \\ \hline  & \multicolumn{2}{c}{**DBUG**} & \multicolumn{2}{c}{**Diluent**} & \multicolumn{2}{c}{**Total**} & \multirow{2}{*}{**Bag Name**} & \multicolumn{2}{c}{**Theoretical**} \\  & & & & **(NaCl 0.9\%)** & & & \\ \hline \multirow{6}{*}{\begin{tabular}{c} RUN\({}^{\circ}\) 1 \\ (High dosage) \\ \end{tabular} } & Cyclophosphamideamide 1 & 1500 mg & 75 mL & 175 mL & 250 mL & Run1\_1 & 6 mg/mL \\  & Cyclophosphamideamide 2 & 1500 mg & 75 mL & 175 mL & 250 mL & Run1\_2 & 6 mg/mL \\  & Cyclophosphamideamide 3 & 1500 mg & 75 mL & 175 mL & 250 mL & Run1\_3 & 6 mg/mL \\  & Cyclophosphamideamide 4 & 1500 mg & 75 mL & 175 mL & 250 mL & Run1\_4 & 6 mg/mL \\  & Cyclophosphamideamide 5 & 1500 mg & 75 mL & 175 mL & 250 mL & Run1\_5 & 6 mg/mL \\ \hline \multirow{6}{*}{\
\begin{tabular}{c} RUN\({}^{\circ}\) 2 \\ (Low dosage) \\ \end{tabular} } & Cyclophosphamideamide 1 & 600 mg & 30 mL & 220 mL & 250 mL & Run2\_1 & 2.4 mg/mL \\  & Cyclophosphamideamide 2 & 600 mg & 30 mL & 220 mL & 250 mL & Run2\_2 & 2.4 mg/mL \\  & Cyclophosphamideamide 3 & 600 mg & 30 mL & 220 mL & 250 mL & Run2\_3 & 2.4 mg/mL \\  & Cyclophosphamideamide 4 & 600 mg & 30 mL & 220 mL & 250 mL & Run2\_4 & 2.4 mg/mL \\  & Cyclophosphamideamide 5 & 600 mg & 30 mL & 220 mL & 250 mL & Run2\_5 & 2.4 mg/mL \\ \hline \multirow{6}{*}{
\begin{tabular}{c} RUN\({}^{\circ}\) 3 \\ (Random dosage) \\ \end{tabular} } & Cyclophosphamideamide 1 & 600 mg & 30 mL & 220 mL & 250 mL & Run3\_1 & 2.4 mg/mL \\  & Cyclophosphamideamide 2 & 700 mg & 35 mL & 215 mL & 250 mL & Run3\_2 & 2.8 mg/mL \\ \cline{1-1}  & Cyclophosphamideamide 3 & 800 mg & 40 mL & 210 mL & 250 mL & Run3\_3 & 3.2 mg/mL \\ \cline{1-1}  & Cyclophosphamideamide 4 & 900 mg & 45 mL & 205 mL & 250 mL & Run3\_4 & 3.6 mg/mL \\ \cline{1-1}  & Cyclophosphamideamide 5 & 1000 mg & 50 mL & 200 mL & 250 mL & Run3\_5 & 4 mg/mL \\ \hline \hline \end{tabular}
\end{table} 
Table 3: Recipe for preparation of infusion bags at different concentrations for the cyclophosphamideamide drug.