## 5 Biomedical Indispensability of the PCL Electrospun Nanocomposites  
The preparation of PCL nanocomposites by the electrospinningning method in order to afford a smooth surface of the nanocomposites materials with large surface area-to-volume ratio, exclusive properties and required applicability, have been intensely explored in the last decades [25; 27; 30; 48; 52; 53; 54; 55; 56; 57; 58; 59; 60; 61; 62; 63; 64; 65; 66; 67; 68; 69; 70; 71; 72; 73; 74; 75; 76; 77; 78; 79; 80; 81; 82]. PCL as a quintessential synthetic thermoplastic that possesses extremely outstanding properties, such as sluggish rate of biodegradability, biocompatible towards numerous materials, thermal stability and can be readily modified. On the account of these phenomenal facets, PCL has been considered as a superb biomaterial, which can be employed in various biomedical applications (_viz._, scaffolds for tissue re-engineering, wound dressing and targeted drug delivery systems) [25; 52; 53]. In addition, the incorporation of a foreign nanoparticle into the PCL matrix can result in the alteration of virtually all the native properties of PCL and account for a specific improvement in which the biomedical utility  
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**PCL Blend or** **Compposite System** & **Preparation (Solvent System)** & **Morphological Results** & **Application** & **Refs. ** \\ \hline Chitosan (CS)/PCL concentrations were electrospun at room temperature & PCL was kept at 6\% and CS was concentration was varied from 0.5\% to 2\%. In the concentration of 0.5\% three concentrations of CS/PCL i.e., 13; 1:1 and 3:1 sweep electrospun. The 1:3 composition showed fine months with uneven morphology. The increase in CS concentration to 1:3 and 3:1 resulted in highly healed fibers. Furthermore, CS was kept at a fixed concentration of 19\%. At 4\% PCL, both 1:3 and 1:1 compositions of 5/PCL gave a beaded fibrous structure. The 3:1 concentration resulted in beaded and irregular fibers & Electrospun scaffold would be applied for biomedical applications & [47] \\ \hline PCL/hydroxapatite (HA)/AZ31/HA treated with PCL/HA by electrospinningpin & PCL/HA was dispersed in chloroform-methanol (3:1 v/v) mixture. HA nanoparticles were added to AZ31 (2.9\% Al, 0.88\% Zn, 0.001\% Fe, 0.02\% Mn and the remaining was Mg) by friction and proliferation. & SEM images showed cell adhesion and proliferation. & Degradation implant applications & [48] \\ PCL/glydeatin were prepared first, then were cross-linked by genipin & PCL/HA was dispersed in chloroform-methanol (3:1 v/v) mixture. HA nanoparticles were added to AZ31 (2.9\% Al, 0.88\% Zn, 0.001\% Fe, 0.02\% Mn and the remaining was Mg) by friction and proliferation. & SEM and AFM images showed that the nanofibress possessed uniform and smooth structures in two (2D) and three (3D) dimension. The average diameters of the nanofibers were in the region of 200–600 nm. The addition of gelatin to PCL improved adhesion and proliferation & [49] \\ PCL/glydeatin were prepared first, then were cross-linked by genipin & PCL/HA was dispersed in chloroform-methanol (3:1 v/v) mixture. HA nanoparticles were added to AZ31 (2.9\% Al, 0.88\% Zn, 0.001\% Fe, 0.02\% Mn and the remaining was Mg) by friction and proliferation. & Guided bone regeneration (Bone tissue engineering) & [49]  
of the resultant PCL/nanofiber composites can be broadly expanded. Notwithstanding the excellent properties of the synthetic PCL thermoplastic and the type of nanofiller introduced into its matrix, electrospinning method has proved to be pertinent for the preparation of PCL/fiber nanocomposites, with desirably envisaged properties for specific applications in the biomedical practices, particularly in the in-vivo cures [20].