## 3 Results and Discussion
### Genomic Characteristics
The dominance of GT2, GH3 and AA3_2 (Figure 8) was also reported for _Penicillium pancosmium_ MUM 23.27 [65] and can highlight a strong metabolic focus on the biosynthesis of structural fungal cell wall polysaccharides (such as chitin and glucan) (GT2); the degradation of plant biomass, particularly complex carbohydrates such as cellulose and hemicellulose (GH3); and the breakdown of lignin (lacases) or the enhancement other lignocellulosic enzymes (AA3_2). The fungal antiSMASH tool predicted the presence of thirty-two putative biosynthetic gene clusters (BGCs) in the genome. From these, nine were T1 PKS, five were NRPS, an additional five were NRPS-like, three were terpenes, two were NRPS, T1 PKS and various single detections of betalactones; fungal-RiPP-like; indole, NRPS; NRP-metallophore, NRPS; NRPS-like, fungal-RiPP-like; NRPS-like, T1 PKS; T1 PKS, indole and T1 PKS, NRPS-like, were also detected. The most relevant and found to hold a higher similarity (>75%) with the MiBiG database pertained to the presence of monascorubrin, nidulanin A, histidyltrytptptpnbaryldiketopiperazine/dehydrohistidyltrytptptpnbaryldiketopiperazine/roqueforine C/glandicoline A/glandicoline B/meleagrine, YWA1 and choline (Table 3). Figure 8: dbCAN3 top 10 carbohydrate-active enzymes counts found in the genome annotation. Figure 7: Eggnog mapper top 10 Clusters of Orthologous Genes (COGs) categories count for the studied genome annotation. Interestingly, a possible homolog for penicillin was also detected in the genome (although with low similarity values) (Table 3 and Figure 9). Recently, the genus _Penicillium_ has been identified as producing some of the most diverse groups of metabolites [70], and the data obtained during the course of this work are in accordance with this observation. Moreover, monascorubrin is a colored polyketide belonging to a class of pigments, known as azaphilones, that possess both coloring and bioactive properties [71, 72]. Nidulanin A represents a cyclic tetrapeptide that is frequently identified within the genera _Aspergillus_ and _Penicillium_[65, 73], for which their biological features are not yet deeply characterized. Regarding the identified histidyltryttopphanyldikeitopiperazine/dehydrohistidyltryttopphanyldiketopiperazine/roquefortine D/roquefortine C/glandicoline A/glandicoline B/meleagrine BGC, they are known to be involved in the synthesis of mycotoxins with some pharmaceutically interesting properties, but they also present some challenges in the food industry [74, 75, 76]. On the other hand, YWA1 is classified as a naphthopyrone pigment and is recognized as a precursor in the biosynthetic pathway of 1,8-dihydroxyoxynaphthalene (DHN)-melanin production [77, 78, 79]. Furthermore, choline serves as a precursor for the production of phospholipids allowing the maintenance of cell membranes, with their derivates being known to be involved in osmotolerance mechanisms in some _Penicillium_ species [80]. Both the presence of YWA1 and choline reinforces a strong focus in the species survival in harsh environments, since they can function as multifaceted protectors against environmental stressors (e.g., [81, 82]). Further studies regarding the synthesis mechanisms and the identity of the possible penicillin homolog, but also from the additional BGCs, remain pending and should be encouraged due to their putative pharmaceutical and biotechnological potentials.