## 3 Results  
Figures 2 and 3 reveal the raw (unfiltered) and superimposed temperature measurement data of all samples within each application group in temperature-controlled and fixed-dose applications, respectively. Further descriptive quantitative data are provided in Table 2 for the temperature-controlled application and in Table 3 and Figure 4 for the fixed-dose application. \begin{table}
\begin{tabular}{c c c c} \hline  & **55 \({}^{\circ}\)C** & **65 \({}^{\circ}\)C** & **75 \({}^{\circ}\)C** \\ \hline
3.4 W & 83.4 J (24.54 s) & 142.5 J (41.91 s) & 215.1 J (63.26 s) \\
6.8 W & 53.5 J (7.87 s) & 74.3 J (10.93 s) & 104.0 J (15.29 s) \\
10.2 W & 41.7 J (4.09 s) & 64.5 J (6.32 s) & 79.8 J (7.82 s) \\ \hline \end{tabular}
\end{table} 
Table 1: Average dose delivered in the temperature controlled (experiment) groups and their equivalent exposure duration for the given power setting in fixed-dose (control) groups. \begin{table}
\begin{tabular}{c c c c c c} \hline \hline \(P_{\text{laser}}\) & \(T_{\text{target}}\) & \(\mu_{\text{T}_{\text{tot}}}(\mu\pm\sigma)\) [\({}^{\circ}\)C] & \(\sigma_{T_{\text{tot}}}(\mu\pm\sigma)\) [\({}^{\circ}\)C] & \(T_{\text{min}}(\mu\pm\sigma)\) [\({}^{\circ}\)C] & \(T_{\text{max}}(\mu\pm\sigma)\) [\({}^{\circ}\)C] \\ \hline \multirow{3}{*}{3.4 W} & 55 \({}^{\circ}\)C & \(54.6\pm 0.1\) & \(0.6\pm 0.1\) & \(52.8\pm 0.4\) & \(55.8\pm 0.5\) \\  & 65 \({}^{\circ}\)C & \(64.5\pm 0.1\) & \(0.5\pm 0.1\) & \(62.8\pm 0.4\) & \(65.6\pm 0.5\) \\  & 75 \({}^{\circ}\)C & \(74.4\pm 0.1\) & \(0.6\pm 0.1\) & \(72.6\pm 0.7\) & \(75.5\pm 0.2\) \\ \hline \multirow{3}{*}{6.8 W} & 55 \({}^{\circ}\)C & \(55.0\pm 0.2\) & \(0.7\pm 0.1\) & \(52.9\pm 0.5\) & \(57.0\pm 0.6\) \\  & 65 \({}^{\circ}\)C & \(64.8\pm 0.2\) & \(0.8\pm 0.2\) & \(62.6\pm 0.6\) & \(66.6\pm 0.6\) \\  & 75 \({}^{\circ}\)C & \(74.6\pm 0.1\) & \(0.8\pm 0.1\) & \(72.4\pm 0.5\) & \(76.4\pm 0.5\) \\ \hline \multirow{3}{*}{10.2 W} & 55 \({}^{\circ}\)C & \(55.3\pm 0.2\) & \(1.0\pm 0.2\) & \(52.8\pm 0.5\) & \(57.8\pm 0.9\) \\  & 65 \({}^{\circ}\)C & \(65.1\pm 0.3\) & \(1.1\pm 0.3\) & \(62.3\pm 0.7\) & \(67.8\pm 1.2\) \\ \cline{1-1}  & 75 \({}^{\circ}\)C & \(74.9\pm 0.8\) & \(1.3\pm 0.8\) & \(71.8\pm 1.3\) & \(77.5\pm 1.1\) \\ \hline \hline \end{tabular}
\end{table} 
Table 2: Descriptive temperature values for the surface temperature controlled application: The mean (\(\mu\)) and standard deviation (\(\sigma\)) values of maximum (\(T_{max}\)), minimum (\(T_{min}\)), mean (\(\mu_{T}\)) and standard deviation (\(\sigma_{T}\)) values of the tissue surface temperature during the 5 s-period at the target value. Figure 2: Temperature monitorization data of surface temperature controlled laser irradiation. The temperature–time response graphs (each individual sample represented with a different curve color) within each group are superimposed. The horizontal black lines and the vertical green lines represent the target temperature values and the laser emission commencement marks, respectively. Figure 3: Temperature monitorization data of the fixed-dose application. The temperature–time response graphs (each individual sample represented with a different curve color) within each group are superimposed. The vertical green lines represent the laser emission commencement marks.