## 2 Results
### 3222401L13 Rik Is a Glial-Enriched lncRNA Showing Increased Expression in Astrocytes of Aged Mice
\begin{table}
\begin{tabular}{c c c c c c c} \hline \hline
**IncRNA Name** & \begin{tabular}{c} **log2 FC 3 vs.** \\ **16 Months** \\ \end{tabular} & \begin{tabular}{c} **\(p\)-adj** \\ **NeuN+** \\ \end{tabular} & \begin{tabular}{c} **Log2 FC** \\ **Neu-vs.** \\ **Neu-** \\ \end{tabular} & \begin{tabular}{c} **\(p\)-adj** \\ **Neu-** \\ \end{tabular} & \
\begin{tabular}{c} **Conserved** \\ **NeuN+** \\ \end{tabular} &
\begin{tabular}{c} **Human Homolog** \\ \end{tabular} \\ \hline \hline \multicolumn{8}{c}{**Upregulated in 16-month-old mice**} \\ \hline
**Neat1** & **0.36** & **1.08 \(\times\) 10\({}^{-5}\)** & **7.82** & **0.00 \(\times\) 10\({}^{+00}\)** & **Yes** & **Neat1** \\ \hline Gm42756 & 0.40 & 2.36 \(\times\) 10\({}^{-5}\) & 9.48 & 3.67 \(\times\) 10\({}^{-83}\) & No & \\ \hline A330023F24 Rik & 0.31 & 1.58 \(\times\) 10\({}^{-4}\) & \(-\)1.90 & 2.71 \(\times\) 10\({}^{-112}\) & Yes & MIR29B2 CHG \\ \hline
9330111N05 Rik & 0.58 & 4.96 \(\times\) 10\({}^{-7}\) & 4.97 & 7.96 \(\times\) 10\({}^{-198}\) & No & \\ \hline Lncpint & 0.47 & 1.32 \(\times\) 10\({}^{-4}\) & \(-\)1.19 & 1.15 \(\times\) 10\({}^{-25}\) & Yes & LINC-PINT \\ \hline
**3222401L13 Rik** & **0.31** & **1.44 \(\times\) 10\({}^{-3}\)** & **4.31** & **2.50 \(\times\) 10\({}^{-177}\)** & **Yes** & **ENSG00000272070** \\ \hline E230029C05 Rik & 0.31 & 4.72 \(\times\) 10\({}^{-2}\) & 1.60 & 4.67 \(\times\) 10\({}^{-43}\) & No & \\ \hline
7630403G23 Rik & 0.86 & 3.96 \(\times\) 10\({}^{-13}\) & 9.74 & 4.32 \(\times\) 10\({}^{-33}\) & No & \\ \hline Gm43242 & 0.31 & 1.41 \(\times\) 10\({}^{-2}\) & 8.54 & 4.00 \(\times\) 10\({}^{-53}\) & No & \\ \hline B230216N24 Rik & 0.51 & 6.73 \(\times\) 10\({}^{-4}\) & \(-\)0.97 & 1.99 \(\times\) 10\({}^{-19}\) & No & \\ \hline AU020206 & 0.47 & 1.31 \(\times\) 10\({}^{-3}\) & 7.18 & 1.94 \(\times\) 10\({}^{-51}\) & No & \\ \hline C130073E24 Rik & 0.54 & 1.45 \(\times\) 10\({}^{-4}\) & \(-\)2.18 & 2.03 \(\times\) 10\({}^{-77}\) & No & \\ \hline Gm5086 & 0.41 & 1.50 \(\times\) 10\({}^{-2}\) & 3.60 & 4.94 \(\times\) 10\({}^{-41}\) & No & \\ \hline A530053G22 Rik & 2.11 & 1.47 \(\times\) 10\({}^{-29}\) & 7.10 & 4.60 \(\times\) 10\({}^{-21}\) & No & \\ \hline Gm12689 & 0.44 & 2.16 \(\times\) 10\({}^{-2}\) & 1.72 & 1.83 \(\times\) 10\({}^{-15}\) & Yes & ENSG00000237163 \\ \hline Gm15802 & 0.45 & 4.73 \(\times\) 10\({}^{-2}\) & 1.78 & 1.13 \(\times\) 10\({}^{-9}\) & No & \\ \hline Gm10069 & 0.77 & 1.78 \(\times\) 10\({}^{-3}\) & 0.99 & 3.31 \(\times\) 10\({}^{-3}\) & No & \\ \hline \multicolumn{8}{c}{**Downregulated in 16-month-old mice**} \\ \hline Mir124-2 hg & \(-\)0.41 & 2.67 \(\times\) 10\({}^{-3}\) & \(-\)2.74 & 9.96 \(\times\) 10\({}^{-267}\) & Yes & MIR124-2 HG \\ \hline Gm4221 & \(-\)1.19 & 4.48 \(\times\) 10\({}^{-12}\) & 3.78 & 1.11 \(\times\) 10\({}^{-48}\) & No & \\ \hline Gm10530 & \(-\)0.46 & 3.75 \(\times\) 10\({}^{-2}\) & 1.48 & 2.29 \(\times\) 10\({}^{-16}\) & No & \\ \hline B130024G19 Rik & \(-\)0.53 & 3.22 \(\times\) 10\({}^{-2}\) & \(-\)1.04 & 4.10 \(\times\) 10\({}^{-10}\) & Yes & NR2F2-A51 \\ \hline
**C430049B03 Rik** & \(-\)**0.82** & **6.31 \(\times\) 10\({}^{-5}\)** & **9.66** & **2.49 \(\times\) 10\({}^{-28}\)** & **Yes** & **MIR503 HG** \\ \hline Gm13270 & \(-\)0.55 & 4.66 \(\times\) 10\({}^{-2}\) & 1.77 & 1.65 \(\times\) 10\({}^{-13}\) & No & \\ \hline Gm45847 & \(-\)0.79 & 4.20 \(\times\) 10\({}^{-2}\) & \(-\)0.88 & 6.30 \(\times\) 10\({}^{-4}\) & Yes & TNRC6A \\ \hline \end{tabular}  
* This table displays the 17 lncRNAs that are significantly altered when comparing NeuN\(-\)nuclei from 3-month-old versus 16-month-old mice. It includes the corresponding fold change (log2 FC 3 vs. 16 months) and adjusted \(p\)-value (\(p\)-adj). The column ‘log2 FC Neu- vs. Neu+’s based on differential expression analysis comparing transcripts in NeuN\(-\) versus NeuN\(-\)nuclei, with a positive value above 4 indicating significant enrichment in NeuN\(-\) nuclei. The columns “Conserved” and “Human Homolog” indicate whether a human homolog exists. LncRNAs in bold indicate the presence of a human homolog.  
\end{table}