## 5 Conclusions  
TS-NP with K-VPRS has been implemented in previous studies [33], but to our knowledge, it has not yet been applied in the neuromotor rehabilitation of children with cerebral palsy (CP). Our study suggests the hypothesis that intensive TS-NT with K-VPRS administered during hospitalization could induce an improvement in motor function in the impaired upper limb of children with unilateral spastic CP. Additionally, our data suggest that TR with K-VPRS can provide continuity or extend the benefits of treatments initiated in rehabilitation centers, which may be critical for maintaining the motor improvements achieved during the hospitalization period. However, randomized, double-blind controlled studies with larger sample sizes are necessary to thoroughly assess the efficacy of K-VPRS-based neuromotor treatments in enhancing upper limb motor function in children with CP. Moreover, the use of K-VPRS relies on various technologies (e.g., internet access), which may hinder accessibility to rehabilitation programs based on this system. Therefore, further studies are needed to fully understand the challenges of implementing K-VPRS-based treatments. Finally, comprehensive cost-effectiveness and economic analyses should be conducted to determine whether rehabilitation with the VPRS, either during hospitalization or through the TR modality, reduces costs for healthcare providers and patients compared to conventional (face-to-face) treatments. The limitations of the present study prevent the generalization of the results observed in our sample and do not allow conclusions to be drawn regarding the effectiveness of the TS-NP with K-VPRS. We are aware that further studies are needed to evaluate the hypotheses raised by the present study. Nevertheless, we consider the data we have collected in the present study encouraging and potentially motivating for further studies concerning the application and the effectiveness of TS-NP with K-VPRS in improving motor function in patients with cerebral palsy. The following supporting information can be downloaded at: [[https://www.mdpi.com/article/10.3390/app142411961/s1](https://www.mdpi.com/article/10.3390/app142411961/s1)]([https://www.mdpi.com/article/10.3390/app142411961/s1](https://www.mdpi.com/article/10.3390/app142411961/s1)). Figure S1: Box plots related to Range of movement scores as measured by Melbourne Assessment 2 at T0. Figure S2: Box plots related to Range of movement scores as measured by Melbourne Assessment 2 at T1. Figure S3: Box plots related to Range of movement scores as measured by Melbourne Assessment 2 at T2. Figure S4: Box plots related to Fluency of movement score as measured by Melbourne Assessment 2 at T0. Figure S5: Box plots related to Fluency of movement score as measured by Melbourne Assessment 2 at T1. Figure S6: Box plots related to Fluency of movement score as measured by Melbourne Assessment 2 at T2. **Author Contributions:** Concept/idea: [PERSON] and L.M. ; Research design: L.M., A.T., G.B., M.D.R., C.F., V.N. and G.P., Writing: [PERSON] and A.T.; Data collection: I.F., M.C.O., I.G., M.D.R., G.A., V.N. and G.P. ; Data analysis: [PERSON], A.T., C.F. and G.P. ; Project management: [PERSON] and [PERSON]; Consultation (including review of manuscript before submitting): [PERSON], A.T., C.F., I.F., M.C.O., I.G., M.D.R., G.A. and G.P. ; Final approval of the Manuscript: [PERSON] and L.M. All authors have read and agreed to the published version of the manuscript. **Funding:** This research was funded by the \"5 per mille\" 2021-funds for biomedical research-Italian Health Ministry-by [PERSON]. **Institutional Review Board Statement:** The study was approved by the Ethic Committee of Istituto Tumori [PERSON]\"--IRCCS, with the reference number 15/CE Medea 19 October 2021. **Informed Consent Statement:** Informed consent was obtained from all subjects involved in this study. **Data Availability Statement:** Data will be available on request to the corresponding author.