## 3 Results

Table 1: Comparison of temperature measurements across different time points among groups. Markers of pancreatic function, however, showed more striking differences. The amylase levels were significantly lower in both the Alcohol and Benzodiazepepines groups compared to the Control group (\(p<0.001\)), and there was also a significant difference between the Alcohol and Benzodiazepepines groups themselves (\(p=0.002\)). Similarly, lipase levels were lower in the treatment groups compared to the Control group (\(p=0.030\)), though no significant difference was found between the Alcohol and Benzodiazepepines groups (\(p=0.7\)). The post hoc comparisons of biochemical parameters revealed several significant differences between the groups (Table 3). Total protein showed large standardized mean differences (SMD) between the control and both treatment groups, with SMDs of 2.3 (\(p=0.016\)) for Control vs. Alcohol and 2.6 (\(p=0.016\)) for Control vs. Benzodiazepepines. However, the difference between the Alcohol and Benzodiazepepines groups was smaller and not statistically significant (SMD = 0.85, \(p=0.3\)). Similarly, globulin levels exhibited significant differences between the control and treatment groups (SMD = 2.4, \(p=0.018\) for Control vs. Alcohol and SMD = 2.1, \(p=0.025\) for Control vs. Benzodiazepepines), but no significant difference was observed between the Alcohol and Benzodiazepepines groups (SMD = 0.55, \(p=0.6\)). For albumin, no statistically significant differences were found between the control and treatment groups (\(p=0.12\) for both comparisons), though the SMDs suggested some degree of variation (Figure 1). The albumin-to-globulin ratio did not show significant  
\begin{table}
\begin{tabular}{c c c c c c c c c c} \hline \hline  & \multicolumn{4}{c}{**Group**} & \multicolumn{4}{c}{**Pairwise Comparisons (\(p\)-Value)**} \\ \hline \multirow{2}{*}{**Variable**} & **Control** & **95\%** & **Alcohol** & **95\%** & **Benzo** & \multirow{2}{*}{**95\% CI 2**} & \multirow{2}{*}{\(p\)-Value 3**} & **Control vs.** & **Control vs.** & **Alcohol vs.** \\  & **(\(p=7\))** & **CI 2** & **(\(p=7\))** & **CI 2** & & & & **Alcohol 4** & Benzodiazepepines 4 & Benzodiazepepines 4 \\ \hline \multirow{2}{*}{**Total Protein (g/L)**} & 77.0 & 76,78 & 71.3 & 68,75 & 67.9 (\(\pm 5.0\)) & 63,73 & **-0.001** & **0.016** & **0.016** & 0.3 \\  & (\(\pm 1.0\)) & 29.6 & 29,30 & (\(\pm 0.8\)) & 28,29 & 26.9 (\(\pm 2.2\)) & 25,29 & **0.024** & 0.12 & 0.12  
differences across the comparisons, with the largest effect size noted in Control vs. Alcohol (SMD = \(-1.5,p=0.2\)). Similarly, the alanine aminotransferase (ALT) levels did not exhibit any significant differences between groups (\(p>0.9\) for all comparisons). In contrast, pancreatic enzymes showed marked differences (Figure 1). Amylase levels were significantly lower in the Alcohol and Benzodiazepepines groups compared to the Control group, with large SMDs of 2.6 (\(p=0.003\)) and 4.6 (\(p<0.001\)), respectively. Additionally, a significant difference was found between the Alcohol and Benzodiazepepines groups (SMD = 3.1, \(p=0.002\)). Lipase levels followed a similar pattern, though the differences between the control and treatment groups were not statistically significant (SMD = 1.6, \(p=0.064\) for both comparisons). No significant difference in lipase was observed between Alcohol and Benzodiazepepines (SMD = 0.48, \(p=0.7\)). Figure 1: Boxplot of biochemical parameters across groups. Statistically significant values in post hoc tests evaluated with Games–Howell post hoc test, corrected for FDR with Benjamini–Hochberg procedure.