## 2 Materials and Methods
### Chemistry
\({}^{13}\)C (125 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 165.0 (d, \(J\) = 253.3 Hz), 159.1, 156.4, 151.6 (d, \(J\) = 13.1 Hz), 148.1 (q, \(J\) = 2.0 Hz), 137.6, 130.1, 122.8 (d, \(J\) = 10.4 Hz), 121.3, 120.5 (q, \(J\) = 256.9 Hz), 115.8 (d, \(J\) = 24.9 Hz), 112.9 (d, \(J\) = 20.4 Hz), 111.8, 42.3, 34.6. \({}^{19}\)F (470 MHz, CDCl\({}_{3}\)) \(\delta\) ppm -57.9 (s, 3F), -105.3 (ddd, \(J\) = 5.3, 9.2, 9.2 Hz, 1F). HRMS (EI), M + 1 calculated for C\({}_{17}\)H\({}_{13}\)F\({}_{4}\)N\({}_{3}\)O, 352.1068, found 352.1072. (7-Chloroquinazolin-4-yl)[2-[4-(trifluoromethyloormethoxy)phenyl]ethylamine, **20a**  
Following general procedure A, using 4,7-dichloroquinazoline (**20**, 100 mg, 0.51 mmol), 2-[4-(trifluoromethyloormethoxy)phenyl]ethylamine (105 mg, 0.51 mmol), and potassium carbonate (78 mg, 0.56 mol) gave **20a** as off-white flaky crystals (72 mg, 50%). mp 153.0-153.4 \({}^{\circ}\)C; \({}^{1}\)H (500 MHz, MCD) \(\delta\) ppm 8.47 (s, 1H), 8.03 (d, \(J\) = 8.6 Hz, 1H), 7.69 (d, \(J\) = 2.1 Hz, 1H), 7.49 (dd, \(J\) = 8.6, 2.1 Hz, 1H), 7.36 (dt, \(J\) = 8.6, 2.7 Hz, 2H), 7.21-7.16 (m, 2H), 3.86 (t, \(J\) = 7.3 Hz, 2H), 3.06 (t, \(J\) = 7.3 Hz, 2H). \({}^{13}\)C (125 MHz, MeOD) \(\delta\) ppm 159.8, 155.8, 149.3, 147.7 (q, \(J\) = 1.7 Hz), 138.6, 130.1, 126.4, 125.4, 123.9, 120.7, 120.5 (q, \(J\) = 255.1 Hz), 113.6, 42.2, 33.9. \({}^{19}\)F (470 MHz, MeOD) \(\delta\) ppm -59.6 (s, 3F). HRMS (EI), M + 1 calculated for C\({}_{17}\)H\({}_{13}\)CIF\({}_{3}\)N\({}_{3}\)O, 368.0772, found 368.0767. (7-Bromoquinazolin-4-yl)[2-[4-(trifluoromethyloormethoxy)phenyl]ethyl]amine, **21a**  
Following general procedure A, using 4-chloro-7-bromoquinazoline (**21**, 75 mg, 0.30 mmol), 2-[4-(trifluoromethyloormethoxy)phenyl]ethylamine (62 mg, 0.30 mmol), and potassium carbonate (41 mg, 0.30 mmol) gave **21a** as off-white crystals (52 mg, 42%). mp 151.8-152.8 \({}^{\circ}\)C; \({}^{1}\)H (500 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 8.68 (s, 1H), 8.06 (s, 1H), 7.56 (s, 2H), 7.32-7.26 (m, 2H), 7.20 (d, \(J\) = 8.0 Hz, 2H), 6.18 (brs, 1H), 3.97 (dt, \(J\) = 6.9, 6.1 Hz, 2H), 3.09 (t, \(J\) = 7.0 Hz, 2H). \({}^{13}\)C (125 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 159.4, 155.7, 149.4, 148.1 (q, \(J\) = 1.6 Hz), 137.4, 130.4, 130.1, 129.7, 127.4, 122.2, 121.3, 120.5 (q, \(J\) = 257.0 Hz), 113.4, 42.5, 34.5. \({}^{19}\)F (470 MHz, CDCl\({}_{3}\)) \(\delta\) ppm -57.9 (s, 3F). HRMS (EI), M + 1 calculated for C\({}_{17}\)H\({}_{13}\)Brf\({}_{3}\)N\({}_{3}\)O, 412.0267, found 412.0246. {2-[4-(trifluoromethyloormethoxy)phenyl]ethyl][7-(trifluoromethyloormethyl)]amine, **22a**  
Following general procedure A, using 7-(trifluoromethyloormethyl)-4-chloroquinazoline (**22**, 100 mg, 0.45 mmol), 2-[4-(trifluoromethyloormethoxy)phenyl]ethylamine (93 mg, 0.45 mmol), and potassium carbonate (69 mg, 0.50 mol) gave **22a** as off-white crystals (82 mg, 55%). mp 149.7-152.3 \({}^{\circ}\)C; \({}^{1}\)H (500 MHz, MeOD) \(\delta\) ppm 8.44 (d, \(J\) = 8.4 Hz, 1H), 8.41-8.37 (m, 1H), 8.01 (s, 1H), 7.86 (dd, \(J\) = 8.4, 1.5 Hz, 1H), 7.42 (dt, \(J\) = 8.6, 2.8 Hz, 2H), 7.31-7.25 (m, 2H), 3.22 (t, \(J\) = 7.7 Hz, 2H), 3.02 (t, \(J\) = 7.7 Hz, 2H). \({}^{13}\)C (125 MHz, MeOD) \(\delta\) ppm 160.4, 148.3 (q, \(J\) = 1.8 Hz), 147.3, 135.8, 135.8 (q, \(J\) = 32.9 Hz), 130.2, 127.7, 125.0, 123.4 (q, \(J\) = 272.4 Hz), 123.1 (q, \(J\) = 3.6 Hz), 122.8 (m), 121.2, 120.5 (q, \(J\) = 255.5 Hz), 119.5, 40.3, 32.4. \({}^{19}\)F (470 MHz, MeOD) \(\delta\) ppm -59.6 (s, 3F), -64.8 (s, 3F). HRMS (EI), M + 1 calculated for C\({}_{18}\)H\({}_{13}\)F\({}_{6}\)N\({}_{3}\)O, 402.1036, found 402.1025. (7-Methoxyquinazolin-4-yl)[2-[4-(trifluoromethyloormethoxy)phenyl]ethyl]amine, **23a**  
Following general procedure A, using 7-(methoxy)-4-chloroquinazoline (**23**, 100 mg, 0.54 mmol), 2-[4-(trifluoromethyloormethoxy)phenyl]ethylamine (110 mg, 0.54 mmol), and potassium carbonate (82 mg, 0.59 mol) gave **23a** as colorless crystals (68 mg, 51%).