## 3 Results
### Detailed Example Case: Fibromyalgiagia with Spleen-Qi Deficiency
#### 3.2.1 Simulated Patient Creation  
Relevant symptom data were first extracted for both the disease (fibromyalgia) and the syndrome (Spleen-Qi deficiency) from our dataset (Table 1). After identifying the key symptoms for each, we then combined the keywords for each question to ensure the symptoms from both the disease and the syndrome were represented. Based on this, we applied prompt engineering techniques to transform these combined keywords into coherent, natural language responses. For example, for the question, \"Could you please describe specifically what you mean by feeling tired?\", we extracted keywords such as \"stiffness in all joints upon waking\" (from fibromyalgia) and \"drowsiness, decreased concentration\" (from Spleen-Qi deficiency). Using prompt engineering, these keywords were combined to create a natural response: \"When I wake up in the morning, all my joints feel stiff and achy. Throughout the day, I often feel drowsy and have trouble concentrating on my tasks\". This approach allowed us to generate responses that accurately reflect the patient's experience, integrating symptoms from both perspectives. This process was applied systematically across all questions in Table 1, combining symptom keywords for each question and utilizing prompt engineering to create natural, patient-centred responses.  
\begin{table}
\begin{tabular}{p{113.8 pt} p{113.8 pt} p{113.8 pt} p{113.8 pt}} \hline \hline
**Question** & **Fibromyalgia** & **Spleen Qi Deficiency** & **Synthesized Patient** \\ \hline Since when have you been feeling fatigued, and how long does the fatigued throughout the day? & Over 3 months & & “I’ve been feeling constantly tired for over three months now, and the fatigue lasts all day.” \\ Could you please describe specifically what you mean by feeling tired? & Stiffness in all joints upon waking in the morning & Drowsiness, decreased concentration & “When I wake up in the morning, all my joints feel stiff. Throughout the day, I feel drowsy and have trouble concentrating.” \\ Does your fatigue worsen at any particular time? & Seems to be getting progressively worse & & “It seems like my fatigue is gradually getting worse over time.” \\ How does your current fatigue compare to when it first appeared? & Along with fatigue, whole-body aches & & “Initially, I was just tired, but now my whole-body aches along with the fatigue.” \\ Do you have any other discomorts? & Stiffness and pain in all muscles & & “Yes, I experience stiffness and pain in all my muscles.” \\ Are there any factors that trigger or worsen your fatigue, such as stressful events or excessive work? & Work & “Work seems to make my fatigue worse, especially when I’m under a lot of pressure.” \\ Does your fatigue improve with sleep or rest? & No, feel stiffer after sleep & Still tired after sleep, slightly better with rest & “Even after sleeping, I still feel tired, and sometimes I feel even stiffer when I wake up. Resting helps a little, but not significantly.” \\ Do you consume alcohol, smoke, or drink coffee? & Coffee to endure work & “I drink coffee to help me get through the workday.” \\ Do you sleep well? How many hours do you sleep per day? & Cannot sleep well & “I don’t sleep well. Even if I sleep around six hours, I wake up feeling unrefreshed.” \\ \hline \hline \end{tabular}
\end{table}
Table 1: Integrated symptom data with patient responses for fibromyalgia with Spleen-Qi deficiency.