## 1 Introduction
### Cannabinoids as Strategic Compounds to Develop New Antibiotics  
Omitting to comment on each strategy reported in Table 1, because it is out of the scope of this study, and instead focusing on the development of alternative antibiotics, we can observe that cannabinoids, better known for many other pharmacological and psychotropic effects are included in this category. Particularly, cannabinoids are prenylated \begin{table}
\begin{tabular}{c c c} \hline \hline \multicolumn{2}{c}{**Strategies for Combating Antibiotic Resistance**} & **Ref.** \\ \hline Nanotechnology & Quality by design (QbD) approach & [13] \\ \hline Computational methods & In silico modelling & [14] \\  & Fragment-based drug design (FBDD) & [15] \\ \hline  & Antimicrobial peptides (AMPs) & \\  & Essential oils & \\  & Anti-Quorum Sensing (QS) & \\  & Darobactins & \\ Antibiotic alternatives & Vitamin B6 & [12] \\  & Bacteriophages & \\  & Odilorhabdins & \\  & 18-\(\beta\)-glycyrrhetic acid & \\  & Cannabinoids & \\ \hline  & Ticagrelor & \\  & Mitomycin C (MMC) & \\ Drug reproposing & Auranofin & [16] \\  & Pentamidine & \\  & Zidovudine (AZT) & \\ \hline  & Lactones & [17] \\ Synthesis of novel & Piperidinol & [18] \\ antibacterial agents & Sugar-based bactericides & [19] \\  & Isooxazole derivatives & [20] \\  & Carbazole & [21] \\ \hline  & Siderophores & \\ Prodrugs & Carbapenem-oxazolidinones & \\  & Oral Gyrb/ParE dual binding inhibitor & \\  & AMPs prodrugs & \\ \hline Development of efficient & Point-of-care tests (POCTs) & \\  & diagnostic agents (RDTs) & Molecular (genotyping) assays & [23] \\ \hline  & Penicillin with streptomycin * & \\  & Rifampin–isoniazid–pyrazinamide ** & \\  & Trimethoprim-sulfamethoxazole & \\  & Quinupristian-dalprotistin & \\ Combination therapy & Beatricin-polymyxin B & \\  & Bacitracin-polymyxin B-gramicidin & \\  & Neomycin,-bacitracin-gramicidin & \\ \cline{2-3}  & \(\beta\)-Lactams antibiotics-\(\beta\)-Lactamase & \\  & inhibitors *** & [25; 26] \\ \hline \hline \end{tabular}
\end{table} 
Table 1: Strategies for combating antibiotic resistance. polyketides produced in _Cannabis_ plants and particularly in _Cannabis sativa_, which is an herbaceous plant that has been used for millennia for both medicinal and recreational purposes. _C. sativa_ possesses a plethora of pharmacological properties and mind-altering effects, largely due to its content in cannabinoids, more precisely phytocannabinois (PCs), given their vegetable origin [28]. Collectively, more than 1600 chemical compounds have been isolated from _C. sativa_, of which over 500 are phytochemicals including cannabinoids, flavonoids terpenoids and sterols [28]. Among phytochemicals, more than 180 are cannabinoids, about 125 have been isolated, that can be classified into 11 structural families [28; 29]. The most abundant representatives of these families are \(\Delta^{9}\)-tetrahydrocannabinol (\(\Delta^{9}\)-THC, also the main psychoactive cannabinoid), cannabidiol (CBD), and cannabichromene (CBC). Additionally, other classes whose prototypes are \(\Delta^{8}\)-\(E\)-tetrahydrocannabinol (\(\Delta^{8}\)-THC), cannabigerol (CBG), cannabinoid (CBND), cannabielsoin (CBE), cannabicylcol (CBL), cannabinol (CBN), cannabitriol (CBT), and a miscellaneous group have been identified [28; 29]. Currently, despite its psychotropic effects, \(\Delta^{9}\)- THC is used as therapeutic agent in the treatment of chemotherapy-associated nausea and vomiting, AIDS related loss of appetite, as well as pain and muscle spasms in multiple sclerosis [30]. Also, its carboxylic acid precursor, THCA, not exerting psycho-active effects in humans, is currently examined for its immunomodulatory, anti-inflammatory, neuroprotective and anti-neoplastic effects as well for its effectiveness in reducing adiposity and preventing metabolic disease caused by diet-induced obesity [31]. CBD, non-psychotropic as well, is currently investigated for application in the treatment of Alzheimer's disease, Parkinson's disease, epilepsy, cancer and for its neuroprotective efficacy [32].