## 3 Results and Discussion
### Interaction between Ummi Dipeptides and Rattus Norvegicus mGluR1 Closed-Open Conformation
\begin{table}
\begin{tabular}{c c c c c c c c c} \hline \hline \multirow{2}{*}{**Legend**} & \multirow{2}{*}{**PubChem ID**} & \multirow{2}{*}{**Binding Energy**} & \multirow{2}{*}{\begin{tabular}{c} **Inhibition** \\ **Constant** \\ **(sM)** \\ \end{tabular} } & \multirow{2}{*}{\begin{tabular}{c} **Protein Residues Involved** \\ **in H-Rond Interactions** \\ **[Chain:Resolute** \\ **(Distance bw Down-Acceptor** \\ **(Protein Donor/Acceptor** \\ **Resolute from side Chaial**)] \\ \end{tabular} } & \multicolumn{2}{c}{**Protein Residues Involved in**} & Involved in Salt Bridges \\  & & & & **[Chain:Resolute** \\ \hline \multirow{4}{*}{DG} & \multirow{4}{*}{151,148} & \multirow{4}{*}{\(-7.12\)} & \multirow{4}{*}{6.00} & \
\begin{tabular}{c} A:Type4 (3.13) (Acceptor,sd) \\ A:Type4 (3.037) (A) (Acceptor) \\ A:Series (2.72 \AA) (Acceptor) \\ A:Series (2.82 \AA) (Dron) \\ A:Series (2.82 \AA) (Dron) \\ A:Series (2.82 \AA) (Dron) \\ A:ThrThruss (8.05 \AA) (Dron) \\ A:Aspis (3.48 \AA) (Acceptor) \\ A:Lys499 (3.90 \AA) (Dron),sd \\ A:Lys499 (3.90 \AA) (Dron),sd \\ \hline \multirow{4}{*}{EE} & \multirow{4}{*}{439,500} & \multirow{4}{*}{5.77} &
\begin{tabular}{c} A:Type4 (2.97) (Acceptor,sd) \\ A:Type4 (3.22 \AA) (Acceptor,sd) \\ A:Series (2.73 \AA) (Dron) \\ A:Series (2.76 \AA) (Dron) \\ A:Series (2.64 \AA) (Acceptor) \\ A:Series (2.61 \AA) (Acceptor) \\ A:Thruss (2.99 \AA) (Dron) \\ A:Gly293 (3.41 \AA) (Dron) \\ A:Gly293 (3.54 \AA) (Dron) \\ A:Gly319 (2.58 \AA) (Acceptor) \\ A:Gly323 (2.44 \AA) (Dron,sd) \\ A:Gly332 (2.44 \AA) (Dron,sd) \\ A:Gly349 (2.80 \AA) (Acceptor) \\ A:Gly499 (2.80 \AA) (Acceptor) \\ A:Gly499 (2.80 \AA) (Acceptor) \\ A:Gly499 (2.81 \AA) (Acceptor) \\ A:Gly50 (2.97 \AA) (Dron,sd) \\ A:Gly516 (2.97 \AA) (Dron,sd) \\ A:Gly529 (3.68 \AA) (Dron) \\ A:Gly53 (3.68 \AA) (Dron) \\ A:Gly540 (3.33 \AA) (Dron) \\ A:Gly540 (3.57 \AA) (Acceptor,sd) \\ A:Gly540 (3.99 \AA) (Carboval) \\ A:Gly540 (3.99 \AA) (Carboval) \\ A:Gly541 (3.99 \AA) (Dron,sd) \\ A:Gly555 (3.86 \AA) (Dron,sd) \\ \hline \hline \end{tabular}
\end{table} 
Table 2: _Cont._  
\begin{table}
\begin{tabular}{c c c c c c c c} \hline  & & & & & & & \\  & & & & & & & \\ \hline \multirow{4}{*}{**Ligand**} & \multirow{4}{*}{**PubChem ID**} & \multirow{4}{*}{**Binding Energy**} & \multirow{4}{*}{**Inhibition**} & \multirow{4}{*}{**Protein Residues Involved**} & \multirow{4}{*}{**Protein Residues Involved in**} & \multirow{4}{*}{**Inolved in**} & \multirow{4}{*}{**Sial Bridges**} \\  & & & & & & & \\  & & & & & & & \\  & & & & & & & \\  & & & & & & & \\  & & & & & & & \\ \hline \multirow{4}{*}{**Ligand**} & \multirow{4}{*}{**PubChem ID**} & \multirow{4}{*}{**Binding Energy**} & \multirow{4}{*}{**Inhibition**} & \multirow{4}{*}{**Constant**} & \multirow{4}{*}{**Lina-Residue**} & \multirow{4}{*}{**No. of**} & \multirow{4}{*}{**Hydrophobic Interactions**} & \multirow{4}{*}{**[Chain-Residue**} \\  & & & & & & \\  & & & & & & \\  & & & & & & & \\  & & & & & & \\  & & & & & & & \\  & & & & & & & \\  & & & & & & & \\ \hline \multirow{4}{*}{**CV**} & \multirow{4}{*}{6,992,567} & \multirow{4}{*}{\(-\)6.96} & \multirow{4}{*}{**7.87**} & \multirow{4}{*}{**A:Cl929**} (2.38 A) (Accepted)**} & \multirow{4}{*}{**A:Cl929**} (3.03 A) & \multirow{4}{*}{**A:Cl929**} (3.19 A) (Carbovolate)**} \\  & & & & & & & \\  & & & & & & \\  & & & & & & \\  & & & & & & \\  & & & & & & \\  & & & & & & \\  & & & & & & \\ \hline \multirow{4}{*}{**CV**} & \multirow{4}{*}{6,993,111} & \multirow{4}{*}{\(-\)8.31} & \multirow{4}{*}{\(0.811\)} & \multirow{4}{*}{**A:Cl92**} (2.72 A) (Accepted)**} & \multirow{4}{*}{**5**} & \multirow{4}{*}{**A:Cl92**} (3.44 A) & \multirow{4}{*}{**A:Cl92**} (3.66 A) (Carbovolate)**} \\  & & & & & & & \\  & &  
Figure 2: Two-dimensional representation of protein–ligand interactions between _Rattus norvegicus_ closed–open  
conformation of mGluR1 (PDB ID: 1 EWK) and Glu (PubChem ID: 33032), AH (PubChem ID: 9837455), DA (PubChem ID: 5491963), DG (PubChem ID: 151148), EE (PubChem ID: 439500), ES (PubChem ID: 6995653), EV (PubChem ID: 6992567), VG (PubChem ID: 6993111).