Moreover, seeds have been found to have the highest concentration of limonoids, with a content of 10.1 g/kg, with limonin being the predominant compound at 5.3 g/kg, whereas flavonoids are typically present in quantities comparable to those found in juice, at 9.9 g/kg [14]. _Citrus_ seeds' bioactive compounds are a source of natural ingredients that can be used in food industries for the formulation of nutraceuticals, functional foods, seed meals, antioxidant preservatives, and oils. They have also gained attention in pharmacological industries for developing, preventing, or treating against many non-communicative diseases and inflammation [15; 16; 17]. They also have a potential application in biodiesel, biosorbent development, cosmetics, and bio-food enhancement formulation [1; 12]. For example, one study found that _C. reticulata_ had a fatty acid profile of 67.4% unsaturated fatty acids (UFA) and 32% saturated fatty acids (SFA). The major components were palmitic acid (26.9%), oleic acid (25.5%), and linoleic acid (37.5%) [12]. Furthermore, _Citrus_ seeds show a good nutritional composition The macronutrient evaluation of dehulled and whole sweet orange seeds displayed a content of 54.2% fat, 28.5% carbohydrate, 5.5% crude fiber, 3.1% crude protein, and 2.5% ash [18]. Regarding the content of amino acids in _Citrus_ seeds, 18 have been reported, with arginine, glutamic acid, and aspartic acid being the most abundant, comprising 14.41% to 19.33% of the total amino acids. The same study concluded that the total content of essential amino acids was comparable with the FAO/WHO standards, between 35.16 g/16 g N for orange seeds and 36.66 g/16 g N for _Citrus_ seeds. Yet the levels of tryptophan are low, with values of 0.19 g for citron and 0.08 g for mandarin oranges [15]. The _Citrus_ seeds' lipids present also very good properties and profiles. Their acid value is ranging between 0.5 and 2.2 mg KOH/g of oil., while their iodine and saponification values are, respectively, estimated in the following ranges: 99.9-110.0 and 180.90-198.90. The lipid characterization of _Citrus_ seeds crude oil revealed the presence of different classes of oil such as free fatty acids, phospholipids, monoglycerides, triglycerides, and sterols. The _Citrus_ seed oil is mainly composed of unsaturated fatty acids (between 33.2 and 38.4%), among which oleic and linoleic acid occupied the first place with a composition varying respectively between 22.3-26.0% and 2.6-9.6%. This oil is also a source of saturated fatty acids like stearic and palmitic acid. Thus, regarding the lipid profile of _Citrus_ seed oil, it could be used for crude consumption in a salad, for cooking, or to produce margarine. On the other hand, its micronutrient composition shows that 100 g of the dried sample contains 160 mg of potassium, 136 mg of calcium, 7.5 mg of sodium, and 0.42 mg of iron [15; 19]. The extraction yield of _Citrus_ seeds oil and phytochemical compounds depends not only on the variety, origin, and growing conditions of _Citrus_ trees, but also on sample-preparation conditions, particle size, the extraction method, the applied conditions, and the type and concentration of solvent. Although the bioactive compounds of the _Citrus_ seed can be extracted by conventional methods like solvent extraction, distillation, and maceration, to both preserve the environment and the bioactive compounds of interest while obtaining the maximum of extractable compounds, novel and greener extraction methods are recommended [1; 9; 20]. For this purpose, innovative extraction methods like ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), pressurized liquid extraction (PLE), pulse electric field extraction (PEF), and supercritical fluid extraction (SFE) using CO\({}_{2}\) as solvent are suggested to obtain better recovery results, with each technique presenting their specifics advantages but also some disadvantages [20; 21; 22; 23; 24].