## 2 Amidoalkyl Naphthols as Bioactive Molecules  
The 1-amidoalkyl-2-naphthols possess diverse biological properties, such as antiviral, antibacterial, antifungal, and antiparasitic qualities [18; 19; 20; 21; 22]. Furthermore, members of this family are promising antioxidants, which also show cholinesterase and \(\alpha\)-glucosidase inhibitory activities [23; 24; 25]. [PERSON] and colleagues evaluated the in vitro antibacterial and antiviral activities of a series of amidoalkyl naphthol derivatives featuring pyrazole or indole fragments [18]. The most potent compounds are illustrated in Figure 2. The results of the antibacterial test revealed that compounds **1** and **4** show high potency against _Staphylococcus aureus_, whereas compounds **2** and **3** have more pronounced inhibitory effects towards _Klebsiella pneumoniae_ and _Bacillus subtilis_, respectively. All four derivatives demonstrated comparable antibacterial activities to the used reference, gentamicin. In terms of antiviral properties, the most active compounds against avian influenza virus (H5N1) were found to be **3** and **5**, which showed similar results to the control, zanamivir. [PERSON] and co-workers synthesized a series of 14 amidoalkyl naphthols bearing an azo-moiety and subjected them to in vitro antimicrobial assays [19]. It was observed that none of the derivatives showed better antibacterial activities than the reference drugs trimethoprim/sulfamethoxazole (SXT) and ciprofloxacin. However, the results from the antifungal test were very promising, since five substances (compounds **6-10**, Figure 3) exhibited better potencies against _Aspergillus niger_ than the standard drugs fluconazole and miconazole. Figure 3: Antifungal amidoalkyl naphthols. Figure 2: Representative amidoalkyl naphthol derivatives with different antibacterial and antiviral properties. Another study by [PERSON] et al., revealed the in vitro anti-_Helicobacter pylori_ activities of various amidoalkyl naphthols [20]. The obtained results illustrated that many of them show promising potency with compound **11** (Figure 4) being the most active against this bacteria. [PERSON] et al., used different benzaldehyde and long-chain amide derivatives to prepare a number of amidoalkyl naphthols, and examined their antibacterial properties in vitro [21]. The results indicated that compounds **12-18** (Figure 5) were the most potent against _Staphylococcus aureus_, exhibiting better activity than the reference, gentamicin. [PERSON] and co-authors reported the antiparasitic activity of a series of 23 amidoalkyl naphthol derivatives [22]. As a result of an in vitro screening against _Leishmana donovani_, followed by a molecular docking study and an in silico study of the ADME (absorption, distribution, metabolism, and excretion) properties of the molecules, four of them (compounds **19-22**, Figure 6) were distinguished as the most promising anti-leishman agents possessing good drug-like characteristics. [PERSON] et al., synthesized 19 amidoalkyl naphthols and evaluated their cholinesterase and \(\alpha\)-glucosidase inhibitory activities [23]. The results of the in vitro assays were backed by a docking study of selected derivatives. The properties of compounds **23** and **24** (Figure 7) were found to be very promising since both substances showed better inhibition on cholinesterase than the reference drug galantamine. Derivative **24** was also the most potent one in the \(\alpha\)-glucosidase assay and exhibited a greater inhibitory effect than quercetin and acarbose, which were used as standards. Figure 4: Promising anti-_Helicobacter pylori_ agent from the amidoalkyl naphthol class. Figure 5: Amidoalkyl naphthols potent against _Staphylococcus aureus_. Figure 6: Amidoalkyl naphthols with antiparasitic properties. In vitro and in silico studies by [PERSON] et al., aimed to estimate the biological potential of another two amidoalkyl naphthol derivatives--**NDHA**[24] and **BHMA**[25] (Figure 8).