# Antibacterialarial Agents Used in Modifications of Dental Resin Composites: A Systematic Review
## 2 Methods
### Article Selection  
Publication abstracts retrieved using search engines were selected using inclusion and exclusion criteria by the first reviewer ([PERSON]). Duplicate articles were removed manually. With the second reviewer's ([PERSON]) participation, we discussed any discrepancies in the evaluation. In the next step, the reviewers ([PERSON] and [PERSON]) evaluated the full articles and the literature references contained in them, which made it possible, through a manual search, to find more articles related to the field of the review. All publications that met the inclusion criteria were downloaded electronically and analyzed (Table 1). Figure 2: Diagram of the PICO structure implemented in this review. \begin{table}
\begin{tabular}{p{113.8 pt} p{113.8 pt} p{113.8 pt} p{113.8 pt}} \hline \hline
**Modification** & \multicolumn{2}{c}{**Microorganisms**} & \multicolumn{1}{p{113.8 pt}}{**Results**} & \multicolumn{1}{p{113.8 pt}}{**References**} \\ \hline Triclosan-encapsulated halloysite nanotubes & _Streptococcus mutans_ & No significant antimicrobial effect was observed between the groups for CFUs and similarly for dry mass & [18] \\ \hline Deep eutectic solvent (DES) with benzalkonium chloride (BC) and acrylic acid (AA) & _Streptococcus mutans_, _Staphylococcus aureus_ & BC-C produced a larger inhibitory halo & [19] \\ \hline MMT loaded with chlorhexidine (CHX) & _Staphylococcus aureus_, _Streptococcus mutans_, _Porphylomonas gingialis_ & Among the three tested bacteria, modified composites exhibited growth inhibition at all concentrations with one exception (2.5\%)—no growth inhibition of _Porphylomonas gingialis_ was observed & [20] \\ \hline Core–shell AgBr/cationic polymer nanocomposite (AgBr/BHPVP) & _Streptococcus mutans_ & Strong bactericidal effect & [21] \\ \hline \multirow{4}{*}{Thyme oil/TiO2 nanoparticle filler acidophilus, Candida albicans} & The resin containing 2 wt\% thymme/TiO2 acidophilus, Candida albicans & & [22] \\ \cline{1-1} \cline{2-3} Tertiary quaternary ammonium acrylamide (AMs) and methylamides (C9 and C14) & _Streptococcus mutans_ and 14 carbons (C9 and C14) & All the C14 versions demonstrated potent antibacterial properties & [23] \\ \hline Nine monomers based on bis-quaternary ammonium salts were prepared & _Streptococcus mutans_, _Escherichia coli_, _Staphylococcus aureus_, _Streptococcus mutans_ biofilms formation & All bis-QAMs were capable of inhibiting _Streptococcus mutans_ biofilms formation & [24] \\ \hline Quaternary ammonium dimethyl-hexadecyl-methacrylammonium iodide (DHMAI), methacryloxymethylphosphorycholine (MPC) & _Streptococcus mutans_ & Reduction in biofilm & [25] \\ \hline Urethane dimethacrylate quaternary ammonium compound (UDMQA-12) & _Streptococcus mutans_ & Significant antibacterial activity & [26] \\ \hline bi-quaternary ammonium methylacrylates (biQAMA-12, biQAMA-14, and biQAMA-16) & _Streptococcus mutans_ & BiQAMA-12 showed the greatest antimicrobial efficacy & [27] \\ \hline Quaternary ammonium urethane-dimethacrylate derivative (QAUDMA-m (m—number of carbon atoms in the N-alkyl substituent—8, 10, 12, 14, 16, 18)) & _Streptococcus mutans_ & Three copolymers, BG\(\cdot\)QA8\(\cdot\)TEG, BG\(\cdot\)QA10\(\cdot\)TEG, and BG\(\cdot\)QA12\(\cdot\)TEG, demonstrated high antibacterial activity against both bacterial strains & [28,29] \\ \hline Dimethylaminododecyl methacrylate (DMADDM) & _Streptococcus mutans_ & The incorporation of 3\% and 5\% DMADDM resulted in a significant decrease in _Streptococcus mutans_ biofilm colony-forming units (CFUs). & [30] \\ \hline Dimethylaminododecyl methacrylate (DMADDM) & _Helicobacter pylori_ & DMADDM reduced H. pylori colonization of oral origin in the stomach, thereby alleviating both local and systemic gastritis & [31] \\ \hline Methacryloyloxydodecylpyridinium bromide (MDP) & _Enterococcus faecalis_ & Significant antibacterial activity & [32] \\ \hline \hline \end{tabular}
\end{table} 
Table 2: Bicoidal dental resin materials.