## 1 Introduction  
The use of emerging technologies is becoming increasingly frequent in the supply chain because they provide flexibility in processes, achieving a reduction in time, cost and degree of complexity. A technology that provides logistical advantages involves drones, which are a delivery alternative due to the growth of demand by electronic commerce, where important parcel delivery companies and other commercial sectors have carried out tests to deliver packages with drones, This is because this technology offers less travel time and lower operating costs compared to trucks, and drones have the advantage that they enable fast and direct delivery from the depot to a customer regardless of the traffic conditions [1]. Useful drone functions include delivery of urgent small items and timely delivery, for example, of urgently needed medications such as blood and vaccines. However, locations needing the delivery may have difficult access due to poor transportation infrastructure, or roads blocked by severe weather, disasters or traffic congestion. Since a drone can fly over an inaccessible road, innovative organizations have begun to use drones for healthcare delivery [2]. UAVs bring different benefits to logistic transportation such as avoiding the congestion of traditional road networks by flying over them, higher speeds than trucks, and lower transportation costs per km [3]. The UAVs are less expensive to maintain than traditional delivery vehicles, such as trucks, and can lower labor costs by performing tasks autonomously. Delivering with drones may be faster than delivering with traditional delivery vehicles, as drones are not limited by established infrastructures such as roads, and generally face less complex obstacle avoidance scenarios [4]. The use of automated UAVs to deliver commercial packages is poised to become a new industry, significantly shifting energy use in the freight sector. If carefully deployed, drone-based delivery could reduce greenhouse gas emissions and energy use in the freight sector [5]. UAV-assisted delivery systems are a reality in the e-commerce business; some recent examples are Google's \"Project Wing\" that tested these vehicles as part of a food delivery system at Virginia Tech [6]. UAVs for logistics may be applied for specific delivery tasks that imply urgency, physical inaccessibility or various types of perils humans may be subjected to if delivering goods [7]. Some advantages of implementing drones identified by [PERSON] and others [8] are the following:  
* Truck-drone hybrid delivery has the potential to provide substantial cost savings, especially in suburban areas. * Incorporating multiple drones per truck offers important but marginally decreasing savings that can be large. * Measures of savings per delivery and savings intensity per square mile provide complementary perspectives that highlight the conditions and regions likely to generate the greatest savings. * The benefits from truck-drone delivery depend strongly on the relative operating costs per mile for trucks and drones, the relative stop costs for trucks and drones, and the spatial density of customers. The use of drones can significantly reduce the traffic-based uncertainty of the shipping process, providing a faster and more reliable service. Both these characteristics increase the probability that customers are home when the shipment is delivered, which, at the same time, helps reducing pollution emissions [9]. UAVs have potential for fast and low cost delivery for short distances, and alternatives for an area of poor transportation infrastructure such as small places [10]. Companies are looking for the best profitable distribution methods for their products in the logistical networks [11]. An alternative of distribution between drones and trucks to improve the delivery companies supply chain has been proposed. The highest logistics cost is the distribution process with 50.3%, therefore, companies should consider using new modes of transport to improve logistics efficiency [12].