## 3 Results and Discussion
### LgAC is an Optogenetic Modulator of cAMP in E. coli
Details of the DEPs are given in Table 1. (**C**) A pie diagram representing the KEGG (Kyoto Encyclopedia of Gene and Genome) pathway analysis output data; tick labels represent the KEGG identifiers (IDs) of the corresponding pathways. Details of the pathways are given in Table 2. \begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Accession No.** & **Differentially Expressed Protein (DEPs)** & **Abv.** & **Log Student’s +Test \(p\)-Value** & \multicolumn{2}{c}{**Abundance (Logs)**} \\ \hline  & & & & **Dark Blue Light** \\ \hline PAARS2 & Glyceraldehyde-3-phosphate dehydrogenase A & GapA & 2.51 & 9.62 & 9.43 \\ A0A387 CPK3* & Phosphoonpolyruvate-protein phosphotransferase & FTS* & 2.22 & 8.45 & 8.23 \\ P21179 & catalase & Katz* & 2.03 & 9.06 & 8.84 \\ B1 DFR1* & Adenylate kinase & Ada* & 2.39 & 8.50 & 8.28 \\ POARK5 & Cysteine synthase A & CysK & 2.29 & 8.54 & 8.41 \\ A0A387 CC21* & Acetate kinase & AckA* & 2.01 & 8.32 & 8.11 \\ PWA991 & Fructose-bisphosphate aldolase class 1 & FRuB & 1.98 & 8.81 & 8.68 \\ P0 ACY3 & Uncharacterized protein & YesC* & 1.89 & 8.54 & 8.22 \\ P0A993 & Fructose-1.6-bisphosphate class 1 & Rpp & 1.96 & 7.99 & 7.79 \\ Q1P72 & Isocidental dehydrogenase (Fragment) & led & 1.87 & 8.54 & 8.32 \\ P0 AC33 & Fumarate hydrolase class 1, aerobic & FumA & 1.90 & 7.93 & 7.80 \\ A0A387 CC22 & 3-oxoxoxox-ACP synthase I & Kasa & 2.15 & 8.04 & 7.80 \\ A0A387 CCV4 & Citrate synthase & GlnA & 2.39 & 7.98 & 7.65 \\ PAAP46 & Phag shock protein A & PgpA & 2.57 & 7.73 & 7.40 \\ P3089 & Putative ABC transporter arghiane-binding protein 2 & Artif & 1.97 & 7.66 & 7.30 \\ P0A677 & ATP-dependent Clp protease proteolytic subunit & Clp* & 2.66 & 8.14 & 7.86 \\ P0A85 & Glutamine synthetase & GlnA* & 2.10 & 8.11 & 7.96 \\ P0A9G6 & Isocittative lyase & AceA & 2.05 & 7.95 & 7.50 \\ A0A387 CC6 & Pyruvate dehydrogenase [ubiquene] & Pdn & 2.28 & 7.72 & 7.42 \\ P0 AC47 & Fumarate reductase non-sulfur subunit & FröB & 2.02 & 8.12 & 7.91 \\ P0A8E7 & UFP234 protein & YajQ* & 1.89 & 8.15 & 7.94 \\ A0A387 CCUS & Glutamine-tRNA ligase & GlnS & 2.14 & 7.77 & 7.59 \\ P7658 & NAD-dependent malic enzyme & Maß & 2.75 & 7.88 & 7.62 \\ A0A387 CCQ4 & Oxidative stress defense protein & nk* & 2.06 & 8.64 & 8.48 \\ A0A387 CD3 & Flagship & FitC* & 2.39 & 8.30 & 8.00 \\ P0A8A0 & Probable transcriptional regulatory protein & Yck* & 2.33 & 7.96 & 7.84 \\ P00363 & Fumarate reductase flavoprotein subunit & FrdA & 3.07 & 8.07 & 7.70 \\ P25516 & Acconitrile hydratase A & AcA & 2.27 & 7.93 & 7.52 \\ C427H6 & Phenylalanine-tRNA ligase alpha subunit & PrDes & 2.14 & 7.80 & 7.41 \\ A0A387D1 KS & Transdatabase & Tal & 2.51 & 8.12 & 7.98 \\ A0A387 CC25 & Transdatabase & Tal & 2.66 & 7.77 & 7.45 \\ P06610 & Thioderosing/glutathione peroxidase & BuiE* & 1.88 & 7.76 & 7.43 \\ P0 ABC3 & Modulator of FSH protease & HfC* & 2.82 & 7.87 & 7.61 \\ P0A677 & Integration host factor subunit alpha & HbA* & 3.01 & 8.61 & 8.43 \\ \hline \hline \end{tabular}
\end{table} 
Table 1: Details of the differentially expressed proteins from light-gated adenylate cyclase expressing _E. coli_ incubated in the dark and illuminated with blue light.