###### Abstract  
Coatings with high water repellence represent a promising field for biomedical applications. Superhydrophobicity (SH) can be used for preventing adhesion, controlling cell deposition, and spreading by inhibition of adsorption processes at liquid-solid interfaces. The recyclability of medical aids like fabrics can open the way for lower cost and more environmentally-friendly solutions. In this case, two different coatings form recyclable and low global warming potential materials and green solvents have been prepared and characterized based on their wettability properties. The resulting substrates have been used for the adhesion and spreading of representative skin cell lines, both tumoral and non-tumoral, showing a strong decrease in cell viability with values \(<\) 10%. The coated substrates showed a complete recovery on initial SH properties after rinsing with suitable solvents. cell viability; fabrics; superhydrophobicity; recyclability; wettability 202020  
loaded with titanium dioxide (TiO\({}_{2}\)) nanoparticles have been investigated in Ref. [5] showing the influence of surface chemistry in reducing cell viability in samples at a higher TiO\({}_{2}\) ratio. The growing potential of SH coatings or materials repelling bacteria settlement or biological fluids with consequent inflammation or infection is studied in Ref. [6]. Polyhexamethylene biguanide has been used in layer by layer application on cotton fabrics, followed by inclusion of an epoxy alkane/epoxy cross-linker. With high contact angle and good shedding angle, these textiles were shown to inhibit biofilm attachment of about 70%. Plasma CVD and UV irradiation have been used to prepare superhydrophobic/philic surfaces as a cell culture scaffold [7]. The adhesion of the cells takes place in a very selective way; in fact, they were arranged in circular shapes corresponding to the fabricated micro pattern. Cell adhesion and spreading on modified surfaces seems to be influenced by contact time on the superhydrophobic surface, while cell proliferation rapidly starts after seeding on the superhydrophobic surface. Proteins adsorbed preferentially on the flat hydrophilic surface than on the flat hydrophobic one. The influence of the composition of poly(dimethylsiloxane) (PDMS) on different types of mammalian cell adhesion and proliferation [8] was comparable to the behavior on tissue culture-treated polystyrene for most of the cell lines growing at similar rates on PDMS substrates and not depending on substrate stiffness in a wide range of [PERSON]'s moduli. In the biomedical field, the malfunctioning of devices is often caused by the uncontrolled adhesion of cells onto synthetic surfaces requiring the control of cell adhesion on artificial surfaces. Cell-resistant polymer coatings like poly ethyleneglycol and zwitterionic polymers have successfully been introduced onto a wide range of surfaces by appropriate immobilization techniques. The advantage of this method is that it can be applied to any material surfaces, including superhydrophobic surfaces. Moreover, it is known that polydopamine-coated surfaces show excellent cell-adhesive properties. Polydopamine-coated superhydrophobic surfaces could then provide an efficient platform for cell adhesion control [9]. Admicellar polymerization (ADPM) has been employed to form thin polystyrene film on cotton [10], improving the coverage by divinylbenzene (DVB) as cross-linking agent. Also, the same technique has been exploited for hydrophobizing cotton fabrics [11] studying the effect of ethanol and methanol on styrene ADPM on polymerization time. SEM characterization revealed ultrathin layers of polystyrene on cotton. The hydrophobicity was tested with wettability and durability investigations finding a moderate water-repellent treatment comparable with stearic acid melamine resins based commercial products. Hydrophobic and hydrophilic FEP Teflon were compared in Ref. [12] for adhesion and spreading of human fibroblasts on untreated FEP-Teflon and tissue culture polystyrene (TCPS).