# SARS-CoV-2 Detection Using Optical Fiber Based Sensor Method
## 3 Literature Review
\begin{table}
\begin{tabular}{c c c c c c} \hline
**No.** & **Type** & **Details** & **Efficiency (\(\boldsymbol{\boldsymbol{\boldsymbol{\boldsymbol{\boldsymbol{\boldsymbol{\boldsymbol{ \boldsymbol{\boldsymbol{\boldsymbol{\boldsymbol{\boldsymbol{\boldsymbol{\boldsymbol{\boldsymbol{ \boldsymbol{ \boldsymbol{ \boldsymbol{ }}}}}}}}}}}}}\))** & **Pros** & **Cons** \\ \hline \multirow{9}{*}{3} & & & Pneumonia patients with & & \\  & & & and without COVID-19 & & & \\  & & & can be identified only & & & \\  & & based on CT imaging and & & validation, the area & & \\  & & diagnosis & clinical symptoms. These & under the curve was & & \\  & & models will be critical for & 0.986 (95 percent & & \\  & & model based & early and easy-to-access & & \\  & & on radio and & diagnosis, especially when & 0.966 1.000) and 0.936 & & \\  & & clinical characteristics [26]. & RT-PCT kits or & (95 percent confidence & \\  & & experimental platforms to & interval 0.866 1.000), & net benefits. & \\  & & screen for COVID-19 & & respectively [27]. & & \\  & & infection are in short & & & \\  & & supply [27]. & & & \\ \hline \multirow{9}{*}{4} & & & A set of four specially & & \\  & & designed primers and a & & & \\  & & DNA polymerase with & & & \\  & & strand displacement & & & \\  & & activity are used in & & & \\  & & this procedure. & manufacture up to 109 & & \\  & & Instead of heat & copies of target DNA & & \\  & & denaturation, LAMP & in less than an hour. & & \\  & & generates a & Detection sensitivity is & & \\  & & single-stranded template & greater than 95\%. & & \\  & & using strand displacement & & & \\  & & polymerase [27] & & & \\ \hline \multirow{9}{*}{5} & & & IgG was found in & & \\  & & & 71.4 percent of all sera & & \\  & & & (197/276), which is & & \\  & & & 192 percent greater & & \\  & & lumunescent & & & \\  & & immunoassays are & & & \\  & & approaches for lowering & & & \\  & & the detection limits of & & & \\  & & antibody-based reagents. & & when the two & \\  & & & fluorescence are & 193 antibodies were & \\  & & commonly used [28] & combined. In SARS, & \\  & & & different sensitivities & & \\  & & & of the 194 IgG and IgM & & \\  & & & detection techniques & & \\  & & & were recorded. & & \\ \hline \multirow{9}{*}{6} & & & & PathSensors Inc. & \\  & & & recently developed a & & \\  & & & CANARY biosensor to & \\  & & Biosensor tests rely on & Within 10 min, the & & detect the new SARS \\  & & optical, electrical, & surface plasmon & coronavirus. This & \\  & & enzymatic and other & resonance (SPR) chip & & \\  & & techniques to translate the & detected anti-SCVme & & \\  & & unique activity of & antibodies at a lower & & \\  & & biomolecules into a & limit of detection of & & \\  & & quantitative output [28]. & 200 ng/mL. & & \\  & & & & \\  & & & & \\ \hline \end{tabular}
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Table 1: _Cont._Figure 3 shows the methodologies employed recently that depict surface plasmon resonance (SPR) configuration (Part I to IV) such as traditional plasmonic based on a coupled prism, plasmonic based on grating (long/short) period and plasmonic based on a waveguide; Part V illustrates a fiber-sensing optical method using a biosensor with nanoparticles. Part VI illustrates surface-enhanced Raman scattering, employing nonpractical materials such as gold and graphene to boost viral sensitivity. The reflecting index (RI) and the wavelength of the laser have a nonlinear connection. Part VII displays structures of laser-induced fluorescence. As a result, altering the refractive index can lower the laser's velocity wavelength in the optic structure. It is also crucial to control the amount of light reflected at the contact, as well as the critical angle for total internal reflection.