### Healing and Repairing Process  
The healing process is based on the intervention of the bone tissue, the bone marrow's cells, the periosteum and the soft tissue [12]. The homeostasis of the bone tissue is kept by the interactions of the osteoblasts, osteoclasts, bone-lining cells and osteocytes, all of them being responsible for the remodelling process [13]. When an interruption in the normal process occurs due to various causes, the aim is to regain the normal function of the tissue. A special category of cells that were discovered in the bone marrow have the power to differentiate into various other cell types, and among them are osteoblasts and chondrocytes. These cells are the mesenchymal stem cells (MSC), and they are defined through several specific surface markers (CD73, CD90 and CD105) [14]. Multiple studies have been conducted and the results revealed an important characteristic of the MSC--a characteristic that offers them a crucial role in the regenerative and reparative process of several adult tissues (bone, muscles, neuronal cells). The immunomodulatory effects of the MSC as proangiogenic, prosurvival and antiappotosis properties transform them into an important adjuvant in tissue engineering and regenerative medicine [14]. In the oral cavity, the oral-derived stem cells (ODSC) can be obtained from the extracted teeth, mainly from the fresh dental pulp. Offering such an easy approach in the oral environment, this type of mesenchymal stem cells has gained the attention of researchers for further studies [15]. Also, similar cell populations have been identified in the periodontal ligament, dental follicle and gingival tissue with remarkable regenerative potential [16; 17; 18]. Further clinical studies that examined the oral bone formation after the removal of periapical cysts, describe the implication of stem-like cells in the local regenerative process, suggesting their presence in the granulation tissue [19]. These results could influence and change the perspective of bone regeneration in the maxillofacial region after the excision of cystic pathology. Multiple studies focus on reporting the existing relationship between the mesenchymal stem cells and bone tissue regeneration. The implication of the TGF1 gene in the differentiation process influences the mesenchymal stem cell's pathway to either an osteogenic or adipogenic cell. The use of PRP blood clot or vitamin D associated with dental-derived mesenchymal stem cells promoted the osteogenic process in the reported studies [20]. Taking into consideration the high potential of the oral cavity's tissues to provide mesenchymal stem cells that can develop into different types of tissue, the path of regenerative medicine encountered a new challenge. The oral mesenchymal stem cells are the target, possessing immunomodulatory molecules that have direct action upon the healing process and the inflammatory alterations. Another possibility that promotes bone healing and regeneration in preclinical and clinical trials is the involvement of growth factors. The results revealed that for the expected results, the dose of growth factors is very high in order to accomplish the desired outcome, generating extreme cell multiplication [21]. In order to accelerate the bone regeneration, nanomaterials could be an option as the dimension is similar to the bone and the shape facilitates the local bioactivity, improving the bone growth. Several studies have revealed that a certain nanotopography of the inserted bone implants can influence bone regeneration. Also, nanomaterials can serve as matrices for the stem cells in order to obtain osteolineage, that could permit their differentiation [21]. Results have been obtained when bioactive coating of the implants occurred. Using titanium implants associated with bioactive coating proved to determine new bone growth at the interface.