## 3 Results of the Literature Review  
A total of eleven studies meeting the selection criteria were selected. Of these, four studies used EEG, six studies used fMRI, and one study used PET. The number of fMRI tests hasgradually increased compared to previous years. The PRISMA flow diagram is presented in Figure 1.  
An overview of all included studies and their results is presented in Table 1.  
Figure 1: PRISMA flow diagram [17]. \begin{table}
\begin{tabular}{c c c c} \hline \hline
**Study (Year)** & **Method/Design** & **Characteristics** & **Main Result(s)** \\  & & **of Samples Studied** & **Statistical Significance** \\ \hline \multirow{4}{*}{[PERSON] et al. (2010) [1]} & Examined brain function in burnout patients by analyzing EEG and neuropsychological outcomes. & 13 burnout subjects (mean age 48.2, range 26–55). & Reduced P300 potency, peak alpha (F = 4.40,df = 1.24, \(p\) < 0.05)and 13 healthy controls & \\  & & 4 females, 9 males in each group. & beta (F = 5.86, df = 1.24, \(p\) < 0.05) in burnout patients. & \\ \hline \multirow{4}{*}{[PERSON] et al. (2016) [18]} & Examined the relationship between potential biomarkers in the alpha frequency band and student self-reports of occupational burnout and the role of gender. & 117 subjects. & IAF is associated with depression and power is associated with burnout (_t_(115) = 3.02, \(p\) = 0.003); \\  & Examined differences in brain activity were investigated by analyzing EEG power versus resting frequency in burnout and control patients. & 46 burnout employees (incl. 19 males). & ground (f(115) = 3.02, \(p\) = 0.003); \\  & Examined differences in brain activity were investigated by analyzing EEG power versus resting frequency in burnout and control patients. & 46 healthy controls (incl. 19 males), mean age: 36.14 years, SD = 7.89. & \ \begin{tabular}{} \end{tabular}  \\  & & 36.14 years, SD = 7.89. & \begin{tabular}{} \end{tabular}  \\  & & & \\ \hline \multirow{4}{*}{[PERSON] et al. (2021) [20]} & Quantitative EEG analysis of different stages of burnout syndrome (tension, resistance, exhaustion). & 131 burnout employees (middle school teachers and medical workers). & At various stages of burnout, an increase in dysfunction of the brain’s regulatory systems was observed, correlating with an increase in the severity of clinical symptoms (_p_ < 0.05). \\ \cline{2-4}  & & 17 internal medicine residents (\(p\) = 0.033), residents mean = 2.33 (SD 2), while internists mean = 0.8 (SD 1.08). \\ \cline{2-4}  & & 17 board-certified internists (\(p\) = 0.011), residents mean = 3.12) while internists mean = 1.67 (SD 1.29). \\ \hline \multirow{4}{*}{[PERSON] (2013) [22]} & Investigated structural changes in the brain in connection with occupational stress in the MRI study (cortical thickness (Chh) and subcortical volumes). & 40 burnout subjects (38 \(\pm\) 6 years, range 19–46 years, 15 males, 25 females). & Reduced volume of the amygdala, caudate nucleus, and impaired motor function in burnout patients (r = 0.44, \(p\) = 0.04; r = 0.43, \(p\) = 0.04). \\ \cline{1-1}  & & 410 brumout subjects (\(p\) = 0.033), residents mean = 2.33 (SD 2), while internists mean = 0.8 (SD 1.08). \\ \cline{1-1}  & & 17 internal medicine residents (\(p\) = 0.033), residents mean = 2.33 (SD 2), while internists mean = 0.8 (SD 1.08). \\ \cline{1-1}  & & 17 board-certified internists (\(p\) = 0.011), residents mean = 3.12) while internists mean = 1.67 (SD 1.29). \\ \hline \multirow{4}{*}{[PERSON] et al. (2013) [21]} & Investigated structural changes in the brain in connection with occupational stress in the MRI study (cortical thickness (Chh) and subcortical volumes). & 40 burnout subjects (38 \(\pm\) 6 years, range 19–46 years, 15 males, 25 females). & Reduced volume of the amygdala, caudate nucleus, and impaired motor function in burnout patients (r = 0.04, \(p\) = 0.04; r = 0.43, \(p\) = 0.04). \\ \cline{1-1}  & & 410 brumout subjects (\(p\) = 0.033), residents mean = 2.33 (SD 2), while internists mean = 0.8 (SD 1.08).