# A Review: Using Multiple Templates for Molecular Imprinted Polymer: Is It Good?
## 3 A Review of MT-MIPs That Have Been Created
### Template
#### 3.1.2 Organic Compounds
\begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Template** & **Monomer** & **Polymerisation** & **Qmax** & **IF** & **Application of** & **Reference** \\ \hline PAHs & P-vinylbenzene & Not mentioned & - & - & SPE & [126] \\ \hline \multirow{4}{*}{\begin{tabular}{c} Aniline \\ Indole \\ 3-methylindole \\ \end{tabular} } & \multirow{4}{*}{\begin{tabular}{c} AAA, AM, and \\ 4-VP \\ \end{tabular} } & \multirow{4}{*}{\begin{tabular}{c} Seeded \\ emulsion \\ polymerisation \\ \end{tabular} } & 47.49 & 5.5 & Not mentioned, but it & \multirow{4}{*}{\begin{tabular}{c} Not mentioned, but it \\ can be utilised in any \\ application where a \\ sorbent is required to \\ purify and concentrate \\ a target analyte \\ \end{tabular} } \\  & & & & & \\ \hline \multirow{4}{*}{\begin{tabular}{c} Aniline \\ Indole \\ 3-methylindole \\ \end{tabular} } & \multirow{4}{*}{\begin{tabular}{c} AAA, AM, and \\ 4-VP. \\ \end{tabular} } & Two-stage & 46.39 & 4.89 & Not mentioned, but it & \multirow{4}{*}{\begin{tabular}{c} Not in any \\ can be utilised in any \\ application where a \\ sorbent is required to \\ purify and concentrate \\ a target analyte \\ \end{tabular} } \\  & & & & & \\ \hline Capsaicin & \multirow{4}{*}{\begin{tabular}{c} AAA and AM \\ \end{tabular} } & Bulk & 0.04625 & \multirow{4}{*}{-} & Not mentioned, but it & \multirow{4}{*}{\begin{tabular}{c} Not in the only \\ can be utilised in any \\ application where a \\ sorbent is required to \\ purify and concentrate \\ a target analyte. \\ \end{tabular} } \\  & & & & & \\ \hline Dimethyl phthalate & \multirow{4}{*}{\begin{tabular}{c} AAA \\ polymerisation \\ \end{tabular} } & \multirow{4}{*}{\
\begin{tabular}{c} Multi-step \\ polymerisation \\ \end{tabular} } & 0.95 & \multirow{4}{*}{-} & Not mentioned, but it & \multirow{4}{*}{
\begin{tabular}{c} Not in the only \\ can be utilised in any \\ application where a \\ sorbent is required to \\ purify and concentrate \\ a target analyte. \\ \end{tabular} } \\  & & & & & \\ \hline \hline \end{tabular}
\end{table} 
Table 5: Organic molecules used as templates for multi-template molecularly imprinted polymers. MT-MIPs synthesised with organic molecules as templates have presented good results, with IF values >1 (Table 5). Using the seeded emulsion polymerisation for aniline, indole, and 3-methylindole as templates produced an IF of 5.5, 4.15, and 3.68. Using two-stage precipitation polymerisation for aniline, indole, and 3-methylindole produced an IF of 4.89, 2.89, and 2.83 [102]. In another study, the IF for 1-naphthol, 9-phenanthrole, and 9-hydroxyfluorene was 3.7, 3.1, and 2.6 [61]. [PERSON] et al. [139] synthesised MT-MIP to synthesise 17 triazine herbicides. MT-MIP was synthesised with atrazine and prometryn as a template, MAA functional monomer, TRIM crosslinker, AIBN initiator, and acetonitrile as porogen. In this study, the synthesis of NIP and ST-MIP for each template was also carried out. MT-MIP produces a selectivity percentage of 72.9%, while NIP produces a selectivity percentage of 30.9%. This shows that the formed MT-MIP has good selectivity. In addition, in comparison with ST-MIP, MT-MIP is more effective for the extraction of several analytes at one time. This is evidenced by the inability of ST-MIP to absorb chloro-triazine while MT-MIP can. The formed MT-MIP also has good reusability. After being used 25 times for five cycles, it was observed that the extraction efficiency was still in the range of 77.8-112.1%. Even after 25 cycles, MT-MIP did not suffer any significant damage [139]. MT-MIPs generated using organic compound templates produced good Qmax values (Table 5), indicating their good selectivity. In one study, MT-MIP was synthesised using MAA as a monomer and methyl parathion as one of the templates; the Qmax was 13.13 [128]. In another study, methyl parathion was used to generate ST-MIP with the same monomer, and the Qmax was 12.9 [140]. However, IF cannot be compared between the study because one of the studies did not include this measurment [128]. In addition, ST-MIP and MT-MIP cannot be compared.