## 1 Introduction  
The roles of oxidative stress and reactive oxygen species (ROS) in the development of neurological disorders, cancer, and diabetes have been well established. Oxidative stress is an imbalance when the body's oxidizing systems, which include numerous free radicals such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as antioxidant systems, which counteract those potentially dangerous free radicals, are out of equilibrium. Oxidative stress has been further reported to be linked with infections, notably those caused by RNA viruses that include corona viruses [1]. Diabetes mellitus is a chronic disease indicated by an unusually high blood glucose level, technically known as hyperglycemia [2]. Diabetes mellitus type 2 has already been known to be a risk factor for SARS-CoV-2 infection. It is reasonable to speculate that hyperglycemia may have a role in the glycation of this protein, triggering a chain of events that results in acute respiratory distress syndrome and mortality of patients with COVID-19 [3].  
Protein glycation changes protein molecular structure, altering enzyme or receptor functioning and activity, and hence plays a vital role in the development of illnesses. Under hyperglycen conditions, advanced glycation end products (AGEs) have been found to be elevated in diabetes mellitus. It is produced by the glycation of biomolecules [2,4]. COVID-19 risk factors have been connected to AGEs [5].  
AGEs create crosslinks with many biomolecules, including proteins, and interact with plasma membrane local AGE receptors (RAGE), modulating intracellular signaling, expression of genes, and the production of free radicals and pro-inflammatory chemicals [6]. AGE/RAGE signaling in diabetes-mediated vascular calcification has been reported to be linked with oxidative stress [7]. Further, the increased production and accumulation of ROS at the inflammatory sites cause tissue damage and endothelial dysfunction leading to inflammatory disorders [8]. Various events such as protein denaturation, increased vascular permeability, and pain are important for inflammation. Chronic inflammation has been found to be involved in cancer development [9]. AGE-modified proteins produce proteinase-resistant and detergent-insoluble aggregates, as well as autoantibodies [10].  
A number of medicinal plants have been identified to be very beneficial in the prevention and treatment of a wide variety of diseases [11]. Myrrh resin is a transparent yellow resin from the tiny, thorny stems of the Commiphora genus tree, most often from _Commiphora myrrha_ and _C. molmol_ species [12]. Myrrh is commonly used as an antiseptic for wounds [13], as a pain reliever [14,15], and in the cholesterol metabolism [16]. In search of new, economic, and effective therapeutic agents against morbidity and mortality of diabetic patients, the purpose of this research is to look at the molecular and cellular effects of myrrh on AGEs' formation, glycation, inflammation, oxidative stress, and other chronic disease risk factors such as oxidative stress using in vitro and in silico studies. The purpose of molecular docking investigations involving superoxide dismutase and catalase with myrrh compounds was to explore the antioxidant activities of myrrh resin extract in reducing oxidative stress and to link the most interesting components to their chemical properties, as well as to explore possible antiviral properties.