## 2 Results and Discussion
### Joint Mobility  
In the overall joint mobility, both groups improved significantly, showing differences to baseline at each time point. In addition, by 3 and 6 months, joint mobility in the aMSCs group was significantly higher than the PRGF group (\(p<0.001\) at both times).  
Regarding the range of motion (ROM), significant improvement was noted in both groups, obtaining significant differences compared to baseline.  
\begin{table}
\begin{tabular}{c c c c c c c c c c} \hline \hline \multirow{2}{*}{**Variable**} & \multirow{2}{*}{**Time**} & \multirow{2}{*}{**Group**} & \multirow{2}{*}{**\(N\)**} & \multirow{2}{*}{**Mean**} & \multirow{2}{*}{**Std. Deviation**} & \multicolumn{2}{c}{**95\% Confidence Interval**} & & \multicolumn{1}{c}{\multirow{2}{*}{**\(p\)-Value**}} \\  & & & & & & & **for Mean** & & **Minimum** & **Maximum** & **between** \\ \cline{5-10}  & & & & & & **Lower Bound** & **Upper Bound** & & & **Groups** \\ \hline \multirow{8}{*}{Muscle Perimeter (cm)} & aMSCs & 34 & 32.56 & 5.37 & 30.69 & 34.44 & 25.00 & 47.00 & \multirow{8}{*}{0.609} \\  & baseline & PRGF & 36 & 32.42 & 3.07 & 31.38 & 33.46 & 27.50 & 41.00 & \multirow{8}{*}{0.005} \\  & Total & 70 & 32.49 & 4.31 & 31.46 & 33.52 & 25.00 & 47.00 & \\ \cline{2-10}  & \multirow{4}{*}{1 month} & aMSCs & 34 & 33.51 * & 4.97 & 31.78 & 35.25 & 27.00 & 45.00 & \\  & & PRGF & 36 & 32.56 & 3.24 & 31.46 & 33.65 & 26.00 & 40.00 & \multirow{4}{*}{0.005} \\  & & Total & 70 & 33.02 & 4.17 & 32.03 & 34.01 & 26.00 & 45.00 & \\ \cline{2-10}  & \multirow{4}{*}{3 months} & aMSCs & 34 & 33.26 * & 4.40 & 31.73 & 34.80 & 28.00 & 43.00 & \\  & & PRGF & 36 & 32.34 & 3.33 & 31.21 & 33.46 & 25.00 & 41.00 & \multirow{4}{*}{0.984} \\  & Total & 70 & 32.79 & 3.89 & 31.86 & 33.71 & 25.00 & 43.00 & \\ \cline{2-10}  & \multirow{4}{*}{6 months} & aMSCs & 32 & 33.98 * & 4.51 & 32.36 & 35.61 & 27.00 & 43.00 & \\  & & PRGF & 34 & 32.50 & 3.35 & 31.33 & 33.67 & 26.00 & 40.00 & \multirow{4}{*}{0.000} \\  & Total & 66 & 33.22 & 4.00 & 32.24 & 34.20 & 26.00 & 43.00 & \\ \hline \multirow{8}{*}{Range of Motion} & aMSCs & 34 & 64.12 & 12.06 & 59.91 & 68.33 & 40.00 & 90.00 & \multirow{8}{*}{0.000} \\  & baseline & PRGF & 36 & 75.61 & 12.22 & 71.48 & 79.75 & 54.00 & 95.00 & \multirow{8}{*}{0.000} \\  & Total & 70 & 70.03 & 13.37 & 66.84 & 73.22 & 40.00 & 95.00 & \\ \cline{2-10}  & \multirow{4}{*}{1 month} & aMSCs & 34 & 96.65 * & 13.21 & 92.04 & 101.26 & 60.00 & 125.00 & \\  & & PRGF & 36 & 87.69 * & 11.71 & 83.73 & 91.66 & 55.00 & 105.00 & \multirow{4}{*}{0.002} \\  & Total & 70 & 92.04 & 13.16 & 88.90 & 95.18 & 55.00 & 125.00 & \\ \cline{2-10}  & \multirow{4}{*}{3 months} & aMSCs & 34 & 103.71 * & 12.26 & 99.43 & 107.98 & 60.00 & 125.00 & \\ \cline{2-10}  & & PRGF & 36 & 92.67 * & 11.35 & 88.83 & 96.51 & 68.00 & 115.00 & \multirow{4}{*}{0.000} \\  & Total & 70 & 98.03 & 12.96 & 94.94 & 101.12 & 60.00 & 125.00 & \\ \cline{2-10}  & \multirow{4}{*}{6 months} & aMSCs & 32 & 107.09 * & 8.56 & 104.01 & 110.18 & 90.00 & 122.00 & \\ \cline{2-10}  & & PRGF & 34 & 90.50 * & 11.24 & 86.58 & 94.42 & 60.00 & 105.00 & \multirow{4}{*}{0.000} \\  & Total & 66 & 98.55 & 12.99 & 95.35 & 101.74 & 60.00 & 122.00 & \\ \hline \hline \end{tabular}
\end{table}
Table 3: _Cont._Regarding the differences between groups there were significant differences from baseline (\(p=0.001\)) with greater range of motion noted in the PRGF group, but since the first visit, animals from the aMSCs group obtained better results at 1, 3 and 6 months (\(p=0.002\); \(p<0.001\); \(p<0.001\); respectively), which indicates that the aMSCs group had a much greater increase in range of motion (Figure 4).