## 4 Discussion
\begin{table}
\begin{tabular}{c c c c c c c} \hline \hline  & \multicolumn{4}{c}{**CFU/mL (Microbial Bodies per 1 g of Tissue or 1 mL of Wound Exudate)**} \\ \cline{2-7}  & \multicolumn{2}{c}{**1 Day**} & \multicolumn{2}{c}{**14 Day**} & \multicolumn{2}{c}{**28 Day**} \\ \cline{2-7}  & **Main Group** & **Control Group** & **Main Group** & **Control Group** & **Main Group** & **Control Group** \\ \hline \multirow{3}{*}{_Klebsiella_ _pneumoniae_} & Me 12 \(\times\) 10\({}^{5}\) & Me 2 \(\times\) 10\({}^{6}\) & Me 7 \(\times\) 10\({}^{5}\) & Me 4 \(\times\) 10\({}^{6}\) & Me 7.5 \(\times\) 10\({}^{4}\) & Me 5.3 \(\times\) 10\({}^{5}\) \\  & [9 \(\times\)10\({}^{5}\); & [11 \(\times\) 10\({}^{5}\); & [1.6 \(\times\) 10\({}^{5}\); & [3.8 \(\times\) 10\({}^{5}\); & [6.25 \(\times\) 10\({}^{4}\); & [2.6 \(\times\) 10\({}^{4}\); \\  & 9.8 \(\times\) 10\({}^{7}\)] & 9.3 \(\times\) 10\({}^{7}\)] & 11 \(\times\) 10\({}^{5}\)] & 16 \(\times\) 10\({}^{6}\)] & 8 \(\times\) 10\({}^{4}\)] & 5.8 \(\times\) 10\({}^{6}\)] \\ \hline \multirow{3}{*}{_Proteus mirabillis_} & Me 17 \(\times\) 10\({}^{6}\) & Me 10 \(\times\) 10\({}^{6}\) & Me 3.6 \(\times\) 10\({}^{6}\) & Me 8.8 \(\times\) 10\({}^{6}\) & Me 5.5 \(\times\) 10\({}^{5}\) & Me 18 \(\times\) 10\({}^{5}\) \\  & [5 \(\times\) 10\({}^{6}\); & [5 \(\times\) 10\({}^{6}\); & [1.05 \(\times\) 10\({}^{6}\); & [5 \(\times\) 10\({}^{6}\); & [1.9 \(\times\) 10\({}^{5}\); & [12 \(\times\) 10\({}^{5}\); \\  & 56 \(\times\) 10\({}^{6}\)] & 44 \(\times\) 10\({}^{6}\)] & 9 \(\times\) 10\({}^{6}\)] & 24 \(\times\) 10\({}^{6}\)] & 6 \(\times\) 10\({}^{5}\)] & 22 \(\times\) 10\({}^{6}\)] \\ \hline \multirow{3}{*}{_Pseudomonas aeruginosa_} & Me 6.5 \(\times\) 10\({}^{5}\) & Me 7.1 10\({}^{5}\) & Me 3.9 \(\times\) 10\({}^{5}\) & Me 7.0 \(\times\) 10\({}^{5}\) & Me 6.7 \(\times\) 10\({}^{4}\) & Me 6.8 \(\times\) 10\({}^{5}\) \\  & [2.3 \(\times\) 10\({}^{5}\); & [2.0 \(\times\) 10\({}^{5}\); & [2.5 \(\times\) 10\({}^{5}\); & [3.7 \(\times\) 10\({}^{5}\); & [5.3 \(\times\) 10\({}^{4}\); & [2.8 \(\times\) 10\({}^{5}\); \\  & 13.8 \(\times\) 10\({}^{5}\)] & 14.2 \(\times\) 10\({}^{5}\)] & 7.5 \(\times\) 10\({}^{5}\)] & 12.5 \(\times\) 10\({}^{5}\)] & 33 \(\times\) 10\({}^{4}\)] & 10.8 \(\times\) 10\({}^{5}\)] \\ \hline \hline \end{tabular}
\end{table} 
Table 4: Dynamics of the level of microbial contamination of bedsores. radicals, nitrate and nitrite anions, peroxynitrite, nitric, and nitrous and peroxynitrous acids) in the environment surrounding the LTP torch, which directly affect the properties of tissues and cells of living organisms [41,42]. This may be due to the ROS-induced initiation of intracellular signaling cascades, including the participation of subcellular organelles (primarily mitochondria), which play a decisive role in the processes of cell differentiation and proliferation, and, on the other hand, trigger the mechanisms of cell death through apoptosis and necrosis [43]. It is known that ROS, along with the induction of destructive processes, can also stimulate regenerative processes in the tissues of living organisms [24, 25, 26]. One of the mechanisms of inducing cell proliferation is the participation of ROS in the activation of mitogenic signaling pathways [44]. It is known that various growth factors with mitogenic activity, such as PDGF, FGFb, and EGF, activate MAP kinase mitogenic pathways in which ROS generated by NADPH oxidase are a necessary component [45]. In this work, we noted the activation of VEGF (Figure 9 and Table 2), which plays an important role in angiogenesis. In addition, there is reason to believe that the LTP discharges are the source of short nanosecond pulses of electric field strength that are capable of inducing electroporation of the cytoplasmic membrane of the cells in the affected area [46, 47, 48]. This is evidenced by the experimental data, according to which the local voltage gradient in the LTP discharge region can reach \(10^{5}\)-\(10^{6}\) V/m [32,49,50].