## 1 Introduction  
In recent years, 2D materials have become more and more popular. This was started in 2004 when [PERSON], [PERSON], and co-workers successfully received graphene by exfoliating graphite with Scotch tape. Layered materials, due to their unique physicochemical properties, can be used in many areas such as chemistry, electronics, and material engineering [1]. In addition, the large surface area of 2D materials makes them suitable for catalysis [2] or sensing. There are also records reporting derivative 2D materials including mesoporous silica on graphene, graphene oxide, or reduced graphene oxide. [PERSON] and co-workers have described the synthesis of mesoporous silica on graphene using cetyl trimethyl ammonium bromide (CTAB) as a structure-directing agent. They believe that this material can be potentially used for lithium ion storage [3]. [PERSON] et al. have successfully synthesized a composite of mesoporous silica with aligned channels vertically to the surface of single-layer graphene oxide. This material shows interesting semi-conductive behavior and sensing property [4]. [PERSON] and his co-workers have reported the synthesis and characterization of small-size mesoporous silica nanoparticles on graphene and explored the effect of experimental parameters such as pH value and the amount of raw materials on the properties and morphology [5]. [PERSON] et al. have described the synthesis of sandwich-like nanosheets from reduced graphene oxide and mesoporous silica with size tunable vertical mesochannels by an oil-water biphasic stratification. They assume that the resultant nanosheets would have a prospect in a large-molecule-weight drug delivery system, which would have both chemical and photothermal therapeutic functions [6]. There is also a report on the formation of a mesoporous silica shell on the surface of double-layered magnesium and aluminum hydroxide (LDH). This research has demonstrated precise control of the thickness and the pore diameter of the mSiO\({}_{2}\) shell on the LDH Mg/Al surface by adjusting the relative amount of LDH Mg/Al or tetraethyl orthosilicate (TEOS) and using the soft template with various hydrocarbon chain lengths [7]. Mesoporous silica and other forms of silica are attractive because of their unique properties such as a hydrophilic surface that is suitable to adsorb some functional groups, tunable size (60 nm-10 \(\upmu\)m) [8], ease of surface functionalization, and low cost of nanoparticles production [9; 10]. However, one of the most important features of silica, thanks to which it can be used in biomedical applications, is its biocompatibility [11] and high specific surface area [12]. Both pristine and functionalized silica spheres have been widely studied for bioapplications--among others, for the storage and release of drugs [13; 14], biosensing [15] and tracking cells [16], hyperthermia [17], and phototherapy [18]. There are also reports regarding functionalization of the silica surface with specific functional groups for targeting purposes. Antibodies [19], aptamers [20], and folic acid [21] have been used for this assignment. Most of the reports are about solid or mesoporous spheres. The flake-like structure of the silica is not yet well studied in this regard. According to the literature, it is possible to produce the nano- and mesoporous silica flakes. [PERSON] et al. have successfully synthesized lotus-leaf-like nanoporous silica flakes using 1-hexadecylamine and tetraethylorthosilicate. They determined that the thickness of the flakes is dependent on the concentration of TEOS. Their structure showed better adsorption properties than its microspheric analogues. The authors also supposed that flake-like properties may allow using them as a support for catalysts [22]. [PERSON] and co-workers have reported the preparation of silica nanoflakes using dual-template synthesis. The pore architectures and morphologies were controlled by the F127 block copolymer and the self-assemblies chiral low-molecular-weight amphiphiles, respectively [23].