# Advances and Challenges in IoT-Based Smart Drug Delivery Systems: A Comprehensive Review
## 3 Applications of Smart Drug Delivery Devices
### Wearable Smart Drug Delivery Devices
#### 3.1.4 Smart Auto-Injectors  
Smart auto-injectors are programmable medical devices that are designed to automatically inject a specific dose of medication. They are also equipped with IoT technology which enables them to connect to other devices or networks and share data in real-time. The IoT-enabled smart auto-injectors are used to administer various types of medication, such as insulin, epinephrine, and other types of drugs. They can be pre-programmed to deliver medication at a specific time or when certain physiological parameters are detected, such as glucose levels in the case of diabetes patients. Table 4 shows some examples of smart auto-injectors for drug delivery.  
\begin{table}
\begin{tabular}{p{56.9 pt} p{56.9 pt} p{56.9 pt} p{56.9 pt} p{56.9 pt}} \hline \hline
**Ref.** & **Brand Name** & **Device Name** & **Key Features** & **Drug Delivered** & **Limitations** \\ \hline \multirow{2}{*}{[32]} & \multirow{2}{*}{Amgen} & \multirow{2}{*}{Neulasta Onpro Kit} & Smart auto-injector treats & \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\begin{tabular}{} \end{tabular} } \\  & & & & \\ \hline \multirow{2}{*}{[33]} & \multirow{2}{*}{Teva Pharmaceuticals} & \multirow{2}{*}{Ajovy Autoinjector} & Smart auto-injector for & \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\begin{tabular}{} \end{tabular} } \\  & & & & \\ \hline \multirow{2}{*}{[34]} & \multirow{2}{*}{AbbVie} & \multirow{2}{*}{Humira Citrate-Free Pen} & \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\begin{tabular}{} \end{tabular} } \\  & & & & \\ \hline \multirow{2}{*}{[35]} & \multirow{2}{*}{Eli Lilly and Company} & \multirow{2}{*}{Trulicity Pen} & \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\
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\begin{tabular}{} \end{tabular} } \\  & & & & \\ \hline \hline \end{tabular}
\end{table}
Table 4: List of smart auto-injectors for drug delivery.  
\begin{table}
\begin{tabular}{p{56.9 pt} p{56.9 pt} p{56.9 pt} p{56.9 pt} p{56.9 pt} p{56.9 pt}} \hline \hline
**Ref.** & **Brand Name** & **Device Name** & **Key Features** & **Drug Delivered** & **Limitations** \\ \hline \multirow{2}{*}{[28]} & \multirow{2}{*}{Teva Pharmaceuticals} & \multirow{2}{*}{ProAir® DighälerTM} & Smart inhaler records usage data, automates dosing. & Albuetrol for the treatment of asthma and COPD & Age restriction, limited emergency use, maintenance required. \\ \hline \multirow{2}{*}{[29]} & \multirow{2}{*}{ResMed} & \multirow{2}{*}{Propeller Health} & Inhaler usage tracker and reminder with app integration and customization. & Various inhaler types for the treatment of asthma and COPD & Limited compatibility, needs patients’ engagement, limited clinical evidence. \\ \hline \multirow{2}{*}{[30]} & \multirow{2}{*}{Adherium} & \multirow{2}{*}{SmartinhalerTM} & Smart inhaler sensor with app integration, tracking usage, reminders, and notifications. & Various inhaler types for the treatment of asthma and COPD & Inhaler compatibility, limited feedback, dependence. \\ \hline \multirow{2}{*}{[31]} & \multirow{2}{*}{CoheroHealth} & \multirow{2}{*}{HeroTracker® sensors} & Wireless sensors track inhaler medication usage automatically and support most inhaler types. & Various inhaler types for the treatment of asthma and COPD & Limited battery life, limited data sharing. \\ \hline \hline \end{tabular}
\end{table}
Table 3: List of smart inhalation devices for drug delivery.