# Role of Nutribiotics in Skin Care
###### Abstract  
The study of the human microbiome has been a hot topic during the recent decades. More recently, the skin microbiome has attracted great interest as well. So, the scientific community has become interested in the role of the skin microbiome in skin health and its relationship with different disorders, such as atopic dermatitis, psoriasis, acne, and rosacea, among others. Numerous studies and investigations have been performed to study the role of pre- and probiotics as nutraceuticalals in the treatment of skin diseases, with growing evidence over the recent ten years. This review gathers information on the use of \"nutribiotics\" in skin care health, focusing on the main dermatological diseases and other skin conditions. Clinical studies show that nutribiotics could be a new tool to improve skin health, and pre-, pro-, syn-, post-, and para-probiotics seem to be beneficial for several skin disorders as well as for repairing the skin barrier and promoting wound healing. In conclusion, the skin microbiome has become a new field with great potential to develop innovative products to manage skin health and diseases. Future advances in this field may facilitate the treatment of skin dysbiosis, with nutribiotics being a suitable method for skin care. nutriacuticals; prebiotics; probiotics; postbiotics; skin microbiome; skin disorders +
Footnote †: journal: Medical  
obesity, allergies, and neurological disorders, among others [2]. One of the objectives of current research is to deepen our knowledge of the intricate relationships between the microbiome and human health in order to develop ways to use the microbiome for therapeutic purposes [1]. The term \"human microbiota\" has been described as the group of symbiotic microorganisms that co-occur with the human organism in balance and without causing damage. The term \"microbiome\" refers to the entire microbiota habitat, including microorganisms, their genomes, and the surrounding environment. Likewise, the aim of the use of prebiotics and probiotics in nutritional therapy is to alleviate these imbalances in the microbiota, and, in parallel, an important industry linked to these nutritional supplements, also called \"nutraceuticals\", has emerged. At the same time, the concept of antibiotics emerged, understood as a general term to refer to the set of microbiotics for human use, also called microbial biotherapy. The role of probiotics in regulating intestinal health has been widely studied in recent decades [3]. Besides that, the concept of prebiotics has been developed, and, later on, the concept of synbiotics, postbiotics, and para-probiotics [4; 5; 6; 7; 8; 9]--in the form of nutraceuticals as oral supplements and for topical applications--was also developed, with the aim of repairing or balancing the microbiota. All these concepts are summarized in Figure 1.  
Since the Russian scientist [PERSON] (1845-1916) coined the concept of probiotic in 1907 [11], numerous studies followed; finally, a consensus definition was proposed by the International Scientific Association of Probiotics and Prebiotics (ISAPP) in 2014, 2017, and 2021, which includes prebiotics, probiotics, and postbiotics definitions. Probiotics were defined as \"live microorganisms that, when administered in adequate amounts, confer a health benefit on the host\" [4]. Prebiotics were defined as \"a substrate that is selectively utilized by host microorganisms conferring a health benefit\" [5]. Postbiotics were defined as follows: \"preparation of inanimate microorganisms and/or their components that confers a health benefit on the host\" [8]. Later on, the concept of synbiotics emerged, being defined as the combination of both prebiotics and probiotics [8].