## 3 Results  
Under the acute stress conditions (Table 2) of the animals in the control group, there was a decrease in the activity of SOD, GPO, AST and AST of the heart. The activity of liver AST increased, and liver ALT decreased. In the animals treated with saline, in general, similar changes were observed. With the use of the enzyme gamma-butyrobetaine hydroxylase inhibitor, the activity of the enzymes did not change as compared to the intact \begin{table}
\begin{tabular}{c c c c c c c c c} \hline \hline  & \multicolumn{2}{c}{**SOD (umol/min g)**} & \multicolumn{2}{c}{**GPO (mmol/min g)**} & \multicolumn{2}{c}{**AST (mmol/min g)**} & \multicolumn{2}{c}{**ALT (mmol/min g)**} \\ \hline  & **Heart** & **Liver** & **Heart** & **Liver** & **Heart** & **Liver** & **Heart** & **Liver** \\ \hline Control group & 49.2 \(\pm\) 8.6 & 337 \(\pm\) 149 & 432 \(\pm\) 131 & 161 \(\pm\) 112 & 91.3 \(\pm\) 36.8 & 115 \(\pm\) 17.6 & 129 \(\pm\) 83.8 & 117 \(\pm\) 51.0 \\ \hline
0.9\% NaCl solution & 43.5 \(\pm\) 23.7 & 347 \(\pm\) 103 & 419 \(\pm\) 109 & 191 \(\pm\) 132 & 105 \(\pm\) 58.0 & 119 \(\pm\) 90.2 & 162 \(\pm\) 92 & 94.5 \(\pm\) 56.3 \\ \hline Inhibitor of the enzyme gamma-butyrobetaine & 50 \(\pm\) 17 & 321 \(\pm\) 134 & 450 \(\pm\) 93 & 217 \(\pm\) 107.9 & 109 \(\pm\) 52 & 105 \(\pm\) 76 & 154 \(\pm\) 117 & 107 \(\pm\) 56 \\ hydroxylase & & & & & & & & \\ \hline Ligusticum wallikii & 45.3 \(\pm\) 16.4 & 350 \(\pm\) 126 & 405 \(\pm\) 101 & 232 \(\pm\) 103 & 106 \(\pm\) 47.0 & 103 \(\pm\) 56.3 & 122 \(\pm\) 93 & 98.3 \(\pm\) 27.9 \\ extract & & & & & & & & \\ \hline Eleutherococcus & 23.4 \(\pm\) 5.7 & 385 \(\pm\) 77.3 & 453 \(\pm\) 86.7 & 241.5 \(\pm\) 81.2 & 105 \(\pm\) 63 & 113 \(\pm\) 96 & 129 \(\pm\) 91.9 & 112 \(\pm\) 98 \\ extract & & & & & & & & \\ \hline \hline \end{tabular} Note: in the table, the data is presented as: average \(\pm\) standard deviation.  
\end{table} 
Table 1: Initial activity of enzymes in groups. level; the activity of liver AST became significantly lower than in the animals of the control group, and the activity of heart AST, and heart and liver ALT was significantly higher. Against the background of Ligusticum wallichii use, the changes were similar; however, the activity of liver GPO and heart AST significantly increased as compared to the initial level. In the group of animals that were treated with Eleutherococcus, compared with the initial level, the activity of SOD of the heart increased, and the activity of SOD of the liver, AST of the liver and ALT of the liver decreased. Changes in the activities of SOD of the heart, AST of the heart, AST of the liver, ALT of the liver were multidirectional (each drug caused its own changes) in the rats of the control group and the rats treated with Eleutherococcus. Under subacute stress conditions (Table 3) in the animals of the control group, the activity of SOD and GPO decreased both in the heart and the liver. In this case, the activities of AST and ALT in both the organs increased; however, the increase in AST activity occurred to a greater extent. The introduction of a saline solution practically did not change these parameters, in comparison with the animals of the control group. When the enzyme gamma-butyrobetaine hydroxylase inhibitor was administered, the activities of all the enzymes, except for liver GPO, were indistinguishable from the intact (pre-intervention) level. In the animals of this group, the activities of all the enzymes, except for liver ALT, significantly differed from the rats of the control group: SOD and GPO upward, and heart AST and ALT downward. The effects of the Ligusticum wallichii extract were generally indistinguishable from the enzyme gamma-butyrobetaine hydroxylase inhibitor, except for the activities of SOD and ALT of the heart, which were lower against the background of a phytopreparation, compared with a synthetic inhibitor.