## 3 Results and Discussion
### Phytochemical Identification of Plant Extract  
The phytochemical characterization of plant extract identified fourteen potentially bioactive compounds in _W. frutescens_ hydroethanolic extract, which represent 99.98% of the total recovered extract that reacted with MSTFA and could be detected by GC-MS analysis. As shown Figure 4 and Table 2, the extract was found to be majorly constituted of methanamine,N,N-di (2-trimethylsilyloxyethyl), bicyclo [3.1.1] heptane, 6,6-dimethyl-2-methylene-, (IS), and bicyclo [2.2.1] hept-2-ene, 2,7,7-trimethyl, with scores of 34.12, 28.48 and 10.19%, respectively. These chemicals cannot be excluded from being involved in the biological activities investigated in the present work such as antidiabetic and antihyperglycemic activities [25; 26; 27]. The present chemicals can react individually or in synergy without excluding potential potentiation effects. The synergistic function of constituents \begin{table}
\begin{tabular}{c c c c c c c c c} \hline \hline \multirow{2}{*}{**Treatment**} & \multicolumn{3}{c}{**Bodyweight Development (mg/kg b.w)**} & \multicolumn{3}{c}{**Biochemical Parameter**} \\ \cline{2-9}  & **Day 1** & **Day 7** & **Day 14** & **Day 21** & **Day 28** & **AST (0/1)** & **ALT (U/1)** & **Urea (g/1)** & **Creatinine** \\ \hline Normal & 234 \(\pm\) 3.3 & 247 \(\pm\) 35\({}^{\star}\) & 253 \(\pm\) 24 \({}^{\star}\) & 26 \(\pm\) 33 \({}^{\star}\) & 272 \(\pm\) 35 \({}^{\star}\) & 253 \(\pm\) 33.73 \({}^{\star}\) & 45 \(\pm\) 6.58 \({}^{\star}\) & 0.25 \(\pm\) 0.04 \({}^{\star}\) & 3.3 \(\pm\) 0.44 \({}^{\star}\) \\ \hline Dab. Control & 239 \(\pm\) 2.1 & 21.8 \(\pm\) 32 & 20.2 \(\pm\) 2.7 & 19.3 \(\pm\) 2.4 & 17.8 \(\pm\) 2.2 & 502 \(\pm\) 48.85 & 134 \(\pm\) 21.2 & 0.64 \(\pm\) 0.06 & 5.9 \(\pm\) 0.83 \\ \hline Dab. Glib. 2 mg & 244 \(\pm\) 2.6 & 23.2 \(\pm\) 1.6 & 24.3 \(\pm\) 23 \({}^{\star}\) & 25.9 \(\pm\) 25 \({}^{\star}\) & 25.8 \(\pm\) 1.77 \({}^{\star}\) & 258 \(\pm\) 25.66 \({}^{\star}\) & 77 \(\pm\) 9.80 \({}^{\star}\) & 0.29 \(\pm\) 0.04 \({}^{\star}\) & 4.3 \(\pm\) 0.44 \({}^{\star}\) \\ \hline Dab. WFRE & 248 \(\pm\) 2.2 & 24.0 \(\pm\) 1.9 & 24.4 \(\pm\) 18 \({}^{\star}\) & 25.0 \(\pm\) 20 \({}^{\star}\) & 26.2 \(\pm\) 22 \({}^{\star}\) & 243 \(\pm\) 27.42 \({}^{\star}\) & 57 \(\pm\) 7.26 \({}^{\star}\) & 0.35 \(\pm\) 0.05 \({}^{\star}\) & 3.80 \(\pm\) 0.46 \({}^{\star}\) \\ \hline Dab. WFRE & 239 \(\pm\) 2.4 & 23.4 \(\pm\) 2.3 & 24.1 \(\pm\) 19 \({}^{\star}\) & 24.9 \(\pm\) 22 \({}^{\star}\) & 26.4 \(\pm\) 21 \({}^{\star}\) & 276 \(\pm\) 23.01 \({}^{\star}\) & 52 \(\pm\) 6.82 \({}^{\star}\) & 0.34 \(\pm\) 0.04 \({}^{\star}\) & 3.70 \(\pm\) 0.32 \({}^{\star}\) \\ \hline \hline \end{tabular}  
* Values are expressed as mean \(\pm\) SD (\(n=5\) mice).
* \(p<\) 0.05, *
* \(p<\) 0.01, **
* \(p<\) 0.001 compared with diabetic control.  
\end{table} 
Table 1: Effect of plant extract on body weight and biochemical parameter development. Figure 3: Plant extract effect on alloxan-induced diabetic mice during the 12 h of the antihyperglycemic test. present in the crude extract can also feature the antidiabetic nature of the plant extract. However, the minor components could interaction with the major chemicals which might affect antidiabetic and antihyperglycemic activities. Thus, testing the entire extract rather than its components is more fitting. Antidiabetic and antihyperglycemic activities can be related to methanaminee,N,N-di (21-trimethylsilyloxyethyl), a major compound of the plant extract. The results obtained agreed with those reported by [PERSON] et al. (2017) [28] who showed that methyl salicate as closer compounds isolated from _Pericampylus glaucus_ [PERSON] had significant hypoglycemic properties in STZ-induced diabetic rats [28]. The other major compounds detected in the extract such as bicyclo1 [3.1.1] heptane, 6,6-dimethyl-2-methylene-, (1S) and 1 bicyclo [2.2.1] hept-2-ene, 2,7,7-trimethyl can also be responsible for the antidiabetic activity even though no previous data have shed light on their activities to the best of our knowledge.