## 3 Results
### Quality Assessment
\begin{table}
\begin{tabular}{c c c c c} \hline \hline \multirow{2}{*}{**Article**} & **Type of the** **Biomaterial** & **Biomaterial’s Shape** & \begin{tabular}{c} **Theoretical Amount of** \\ **Sr in the Biomaterial** \\ **(wt.\%)** \\ \end{tabular} & \begin{tabular}{c} **Amount of** \\ **from Biomaterial** \\ **(wt.\%)** \\ \end{tabular} \\ \hline \multirow{2}{*}{[PERSON] et al. [37]} & \multirow{2}{*}{Sr-HA} & Coating on PET \\  & & artificial ligaments \\ \hline [PERSON] et al. [60] & \multirow{2}{*}{Sr-HA} & Spheres & 0.71 (at.\%) & Not specified \\ \hline [PERSON] et al. [38] & \multirow{2}{*}{Sr-HA} & Discs & 50 (at.\%) & \(\sim\)8 ppm (SBF) and 20 ppm (PBS) after 28 days \\ \hline [PERSON] et al. [40] & \multirow{2}{*}{Sr-HA} & Powder & 1, 5 and 10\% (Sr substitution) & 5.05, 12.7 and 19.46 ppm in media after 24 h. \\ \hline [PERSON] et al. [41] & \multirow{2}{*}{Sr-HA} & Coatings on Activated \\  & & Carbon Fiber Cloth \\ \hline [PERSON] et al. [42] & \multirow{2}{*}{Sr-HA} & Powders and Pellets & \begin{tabular}{c} 10\%, 30\%, 50\%, 70\% of \\ Ca replaced by Sr \\ \end{tabular} & Not specified \\ \hline [PERSON] et al. [43] & \multirow{2}{*}{Sr-HA} & Porous Scaffold & 2.8 wt\% & Not specified \\ \hline [PERSON] et al. [44] & \multirow{2}{*}{Sr-CHA} & Microspheres & 5 (at.\%) & \(\sim\)4 ppm (culture medium) \\  & & & after 24 h \\ \hline [PERSON] et al. [45] & \multirow{2}{*}{Sr-nHAp} & Powder & 1, 3 and 10 wt\% & up to 1 mg/mL \\ \hline [PERSON] et al. [46] & \multirow{2}{*}{Sr-\(\alpha\)-TCP cement} & Disc & 8.3 and 16.7\% & Not specified \\ \hline [PERSON] et al. [47] & \multirow{2}{*}{Sr-CaP} & Nanotubes & 10\% and 50 at.\% & 2–18 mg/L \\ \hline [PERSON] et al. [48] & \multirow{2}{*}{Sr-CPC} & Scaffolds & 8 (at.\%) & \(\sim\)0.020 ppm (SBF) after 4 weeks \\ \hline [PERSON] et al. [49] & \multirow{2}{*}{Sr-CaP} & Scaffold & 4.2\% & Not specified \\ \hline [PERSON] et al. [50] & \multirow{2}{*}{Sr-CaP} & Coating on \\  & & titanium alloy & 2 wt\% & Not specified \\ \hline [PERSON] et al. [61] & \multirow{2}{*}{Sr-HA} & Rod (titanium coating) & \begin{tabular}{c} 5, 10 and 20 (7.6, 13 and \\ 22.7 experimental) \\ \end{tabular} & Not specified \\ \hline [PERSON] et al. [62] & \multirow{2}{*}{Sr-HA} & \multirow{2}{*}{Disks} & (9.1, 91 and 98.6 \\  & & experimental) (at.\%) & Not specified \\ \hline [PERSON] et al. [51] & \multirow{2}{*}{Sr-HA} & Injectable Gel & 15 mol\% & Not specified \\ \hline [PERSON] et al. [63] & \multirow{2}{*}{Sr-HAP/TCP} & Granules & 5 wt\% & Not specified \\ \hline [PERSON] et al. [52] & \multirow{2}{*}{Sr-HA} & \multirow{2}{*}{Discs} & 10, 40 and 100 (8.73, 37.95 and 100 \\  & & experimental) (at.\%) & \begin{tabular}{c} 14, 35 and 50 ppm (DMEM) \\ after 24 h. \\ \end{tabular} \\ \hline [PERSON] et al. [64] & \multirow{2}{*}{Sr-HA} & \begin{tabular}{c} Cylinders (titanium \\ coating) \\ \end{tabular} & 2.5 (at.\%) & \
\begin{tabular}{c} \(\sim\)0.53 ppm (NaCl 0.9\%) \\ after 24 days \\ \end{tabular} \\ \hline [PERSON] et al. [53] & \multirow{2}{*}{Sr-ABS} & Scaffolds & \(\sim\)2–5 experimental & \(\sim\)5 ppm (deionized water) \\  & & (at.\%) &
\begin{tabular}{c} after 5 days \\ after 5 days \\ \end{tabular} \\ \hline [PERSON] et al. [54] & \multirow{2}{*}{Sr-HA} & Whisker-like Scaffolds & 10\% & 1.5–2.0 ppm (in vitro, over 7 days) \\ \hline [PERSON] et al. [55] & \multirow{2}{*}{Sr-HA} & Scaffolds (titanium \\  & & coating) & 16.5 (at.\%) & Not specified \\ \hline \hline \end{tabular}  
* Sr-OCP = octacalcium phosphate; Sr-CaP = strontium calcium phosphate; Sr-CPC = strontium calcium cement; Sr B-TCP = strontium B-tricalcium phosphate; Sr-TCP = strontium tracticum phosphate; Sr-CPP = strontium calcium polyphosphate particles; Sr-ABS = Allograft Bone Scaffolds.  
\end{table} 
Table 3: _Cont._were characterized for their strontium incorporation and release properties, which are crucial for their performance in bone regeneration applications.