## 3 Results
In the multivariate analysis, significance was retained for patient age (the probability of periodontitis increasing with age) and smoking (the probability of periodontitis in smokers being 2.87 times more likely than among non-smokers) (Table 6). Of the total 241 implants analyzed in the study, only 7% presented some degree of peri-implantitis. In the univariate analysis, the following results in relation to the presence \begin{table}
\begin{tabular}{c c c c c} \hline \hline  & \multicolumn{2}{c}{**Univariant Logistic Regression**} & \multicolumn{2}{c}{**Multivariant Logistic Regression**} \\ \cline{2-5}  & **OR (IC 95\%)** & _p-Valor_ & **OR (IC 95\%)** & _p-Value_ \\ \hline Gender & & & & \\ Male & 1 & & & \\ Female & 0.85 (0.45–1.62) & 0.625 & & \\ Age & 2.05 (1.83–4.97) & \textless{}0.001 & 2.03 (1.72–4.86) & \textless{}0.001 \\ Medical Treatment & & & & \\ No & 1 & & 1 & \\ Yes & 2.81 (1.39–5.69) & 0.004 & 1.24 (0.45–3.43) & 0.682 \\ Tabacco consumption & & & & \\ No & 1 & & & \\ Yes & 2.30 (1.15–4.58) & 0.018 & 2.87 (1.18–6.95) & 0.020 \\ Alcohol consumption & & & & \\ No & 1 & & & \\ Yes & 1.49 (0.77–2.89) & 0.241 & & \\ Body Mass Index & 1.03 (0.95–1.13) & 0.473 & & \\ \% O’LEARY’s plaque index & 1.95 (1.18–3.22) & \textless{}0.001 & 1.07 (0.99–1.15) & 0.094 \\ Brushing frequency & & & & \\
2/day & 1 & & 1 & \\
3 or more/day & 0.39 (0.19–0.77) & 0.007 & 0.86 (0.35–2.10) & 0.732 \\ Bleeding & & & & \\ No & & & & \\ Yes & & & & \\ CUPRAC (mmol/L) & 1.48 (0.27–8.25) & 0.655 & & \\ FRAP (mmol/L) & 1.03 (0.49–2.14) & 0.943 & & \\ TEACH (mmol/L) & 1.20 (0.24–5.89) & 0.827 & & \\ AOPP (\(\upmu\)mol/L) & 1.00 (1.00–1.00) & 0.099 & & \\ PT (mg/dL) & 1.00 (1.00–1.01) & 0.151 & & \\ \hline \hline \end{tabular}
\end{table} 
Table 6: Effect of demographic and clinical variables and salivary markers on the course of periodontitis. \begin{table}
\begin{tabular}{c c c c c c c} \hline \hline  & \multicolumn{1}{c}{**Healthy**} & \multicolumn{1}{c}{**Periodontitis**} & \multicolumn{2}{c}{**\(p\)-Value**} & \multicolumn{2}{c}{**Healthy**} & \multicolumn{2}{c}{**Periodontitis**} \\  & **No Implant** & **No Implant** & & & **Implant** & \\  & & & & & _p-Value_ & \\ \hline CUPRAC (mmol/L) & 0.29 (0.25) & 0.28 (0.17) & 0.903 & 0.27 (0.16) & 0.30 (0.14) & 0.352 \\ FRAP (mmol/L) & 0.60 (0.61) & 0.58 (0.39) & 0.861 & 0.57 (0.35) & 0.60 (0.32) & 0.695 \\ TEACH (mmol/L) & 0.32 (0.26) & 0.32 (0.18) & 0.939 & 0.31 (0.18) & 0.32 (0.17) & 0.653 \\ AOPP (mmol/L) & 318.68 (308.81) & 608.67 (108.45) & 0.11 & 331.85 (346.96) & 531.97 (1.008.24) & 0.239 \\ PT (mg/dL) & 65.74 (46.82) & 82.97 (54.15) & 0.141 & 66.33 (54.23) & 74.49 (60.00) & 0.528 \\ \hline \hline \end{tabular}
\end{table} 
Table 5: Descriptive and comparative salivary markers between healthy patients and patients with controlled periodontal disease, with and without implants. of peri-implantitis were recorded: absence or presence of periodontal disease (odds ratio [OR] 0.89. 95% confidence interval [95%CI] 0.33-2.39) (\(p\) = 0.815); implant location in the maxilla or mandible (OR 0.76. 95%CI 0.28-2.03) (\(p\) = 0.58); years of implant in place (OR 1.14. 95%CI 0.95-1.38) (\(p\) = 0.168) (Table 7).