## 3 Results and Discussion
### Exposure Assessment  
#### 3.3.1 Health Effect #01  
Based on the results of consumption survey and laboratory analysis of agricultural products, Table 4 shows the calculated EDI for the young population in Serbia for the \"as is\" scenario. The highest EDI was observed for crypordinil (0.067 ug/kg bw/day)--FFQ recall; 0.056 ug/kg bw/day--24 h recall) and boscalid (0.047 ug/kg bw/day--FFQ recall; 0.023 ug/kg bw/day--24 h recall). This fact is not surprising since animopyrimidine (AP) fungicide cyprodinil, currently classified as potential methionine biosynthesis inhibitors, and boscalid, fungicide belonging to the class of carboxamides which inhibits enzyme succinate dehydrogenase in fungal cells [39], are widely used in Serbia for the control of several diseases, especially grey mold (_Botrytis cinerea_) on grapevine, raspberries and strawberries; apple scab (_Venturia inaequalis_) and brown rot (_Monilia_ spp.) of stone fruits. Estimated daily intake of active substances for two recall periods for differebt scenarios and 'health effect #1' are displayed in Supplementary Table S2a, S2b and S2c. All calculate EDI values (expressed in ug/kg bw/day) are lower than ADI values (expressed in mg/kg bw/day). Acceptable Daily Intake values is provided in Supplementary Table S3. The estimates of the MOETs and their mean values, as well as their 95 th and 99 th percentile of the exposure assessment are shown in Figure 1, for two recall scenarios--FFQ recall and 24 h recall. The 99 th percentile in 10 European populations covering toddlers, other children and adults ranged between 155 and 401. This study included traces of active substances with effects on hypothyroidism captured from the official pesticide monitoring programs of the EU member states during the period 2014-2016 [17]. MOET results from \begin{table}
\begin{tabular}{c c c c c c} \hline \hline \multirow{2}{*}{**Active Substance**} & **NOAEL** & **ADI** & \multicolumn{2}{c}{**EDI Values (ug/kg bw/day)**} & \multicolumn{2}{c}{**EDI Values (ug/kg bw/day)**} \\  & **(mg/kg bw/day)** & **(mg/kg bw/day)** & **FFQ Recall** & \multicolumn{2}{c}{**24 h Recall**} \\  & **(mg/kg bw/day)** & **Mean** & **95 th Percentile** & **Mean** & **95 th Percentile** \\ \hline Boscalid & 22 & 0.044 & 0.047 & 0.232 & 0.023 & 0.088 \\ Buprofearine & 0.9 & 0.010 & 0.002 & 0.010 & 0.001 & 0.002 \\ Cyratanilipole & 7 & 0.010 & 0.001 & 0.002 & 0.000 & 0.003 \\ Cyprocanazole & 24.7 & 0.020 & 0.002 & 0.008 & 0.001 & 0.008 \\ Cyprodini & 3.14 & 0.030 & 0.067 & 0.248 & 0.056 & 0.414 \\ Dithianon & 7.9 & 0.010 & 0.000 & 0.002 & 0.000 & 0.000 \\ Fenbuconazole & 3 & 0.006 & 0.005 & 0.022 & 0.003 & 0.007 \\ Fluorpicolide & 32 & 0.080 & 0.003 & 0.010 & 0.003 & 0.022 \\ Fluorpyram & 1.2 & 0.012 & 0.007 & 0.029 & 0.003 & 0.017 \\ Fluasymyroaxd & 2.7 & 0.020 & 0.005 & 0.017 & 0.004 & 0.013 \\ Folpet & 68.4 & 0.100 & 0.002 & 0.006 & 0.002 & 0.009 \\ Mycobutanil & 15 & 0.025 & 0.003 & 0.010 & 0.002 & 0.011 \\ Pendimethain & 43 & 0.125 & 0.001 & 0.003 & 0.000 & 0.002 \\ Pyrimethanil & 17 & 0.170 & 0.030 & 0.132 & 0.013 & 0.041 \\ Spinosad & 2.7 & 0.024 & 0.007 & 0.031 & 0.005 & 0.000 \\ Spirodicofen & 19.88 & 0.015 & 0.002 & 0.007 & 0.002 & 0.013 \\ Spiropinestien & 6.5 & 0.030 & 0.003 & 0.012 & 0.001 & 0.009 \\ Thabendazole & 10 & 0.100 & 0.010 & 0.047 & 0.005 & 0.033 \\ Thiophene-methyl & 8 & 0.020 & 0.005 & 0.024 & 0.002 & 0.000 \\
2,4-D & 75 & 0.050 & 0.003 & 0.010 & 0.001 & 0.000 \\ Bitternald * & 100 & 0.003 & 0.000 & 0.000 & 0.000 & 0.000 \\ Carbaryl * & 60.2 & 0.007 & 0.000 & 0.000 & 0.000 & 0.000 \\ Chlorpropham * & 5 & 0.007 & 0.004 & 0.013 & 0.003 & 0.014 \\ Lufenuron * & 0.4 & 0.015 & 0.000 & 0.000 & 0.000 & 0.000 \\ Pyridially * & 47.4 & 0.030 & 0.000 & 0.000 & 0.000 & 0.000 \\ Terbuthyalaxie * & 6.97 & 0.004 & 0.000 & 0.002 & 0.000 & 0.000 \\ Tetraconazole * & 1 & 0.004 & 0.000 & 0.000 & 0.000 & 0.000 \\ Thiacloprid * & 1.2 & 0.010 & 0.000 & 0.002 & 0.000 & 0.000 \\ Thiamethoxam * & 198.6 & 0.026 & 0.001 & 0.005 & 0.001 & 0.005 \\ \hline \hline \end{tabular}
\end{table}