## 1 Introduction
### Membrane Proteins of Gram-Negative Bacterium Species
\begin{table}
\begin{tabular}{c c c} \hline \hline
**Species** & **Concluding Analysis** & **Membrane** \\  & **Proteins/Channels/Porins** \\ \hline _Pseudomonas_ & Showed and explained amino acid substrates uptake/translocation in-order to & OccD1 \\ _aeruginosa_ & recognize the structure and dynamics of pore [132]. & OccD3 \\ \hline _Pseudomonas_ & Showed and explained impenem and meropenem uptake [42]. & OccD3 \\ \hline _Pseudomonas_ & Showed and explained membrane protein’s role in citrate, isocitrate, and & OccK5 \\ _aeruginosa_ & tricarboxylate uptake [133]. & OccK5 \\ \hline _Pseudomonas_ & Showed and explained the different distinct gating mechanisms of & OccK5 \\ _aeruginosa_ & the channel [134]. & OccK5 \\ \hline _Pseudomonas_ & Examined and described the contribution of the membrane proteins in the & OccK1, \\ _aeruginosa_ & transport of temocillin [135]. & OccK2 \\ \hline _Pseudomonas_ & The ionic selectivity of the phosphate-specific pore was investigated and & \\ _aeruginosa_ & elucidated. The energetic properties, particularly for phosphate, chloride, & OprP \\  & potassium, and sulfate ions, were determined [34; 136]. & \\ \hline _Pseudomonas_ & Explored, confirmed, and elucidated the significance of negatively charged & \\ _aeruginosa_ & residue (D94) in central binding for specific phosphate binding & OprP \\  & and selectivity [137]. & \\ \hline _Pseudomonas_ & The role of the central arginine (R133) in determining channel selectivity and & \\ _aeruginosa_ & ion transport properties has been investigated and established [138]. & OprP \\ \hline _Pseudomonas_ & The impact of important residues on channel constriction and their influence & \\ _aeruginosa_ & on the substrate specificity of the membrane protein has & OprP and OprO \\  & been investigated [139]. & \\ \hline _Pseudomonas_ & Demonstrated declined membrane protein production to be only of the & \\ _aeruginosa_ & causative considerations for carbapenem hetero-resistance [140]. & OprD \\ \hline _Pseudomonas_ & The role of membrane proteins in increasing the minimal inhibitory & \\ _aeruginosa_ & concentrations of carbapenems in clinical isolates has been investigated & OprD \\  & and confirmed [141]. & \\ \hline _Pseudomonas_ & Examined and recognized membrane protein levels in distinct & \\ _aeruginosa_ & carbapenem-resistant isolates [142]. & OprD \\ \hline _Pseudomonas_ & Recognized conflicting susceptibility of carbapenem together with alterations & \\ _aeruginosa_ & in outer membrane permeability [143]. & OprD \\ \hline _Pseudomonas_ & The in vitro activity of ceftolozane-tazobactam and ceftazidine-aubactam & \\ _aeruginosa_ & against meropenem-resistant bacterial isolates was examined & OprD \\  & and confirmed [144]. & \\ \hline _Pseudomonas_ & Examined and recognized distinctive membrane proteins in-frame deletions & \\ _aeruginosa_ & amongst particular clinical isolates [145]. & OprD \\ \hline _Pseudomonas_ & Researched distinct adaptations of membrane proteins domination in -isolated & \\ _aeruginosa_ & resistant stains, particularly towards impenem [146]. & OprD \\ \hline _Pseudomonas_ & Investigated the structure-porin permeation relationships of a group of novel & \\ _aeruginosa_ & carbapenem analogs across the membrane protein [147]. & OprD \\ \hline _Pseudomonas_ & The influence of membrane protein polymorphisms, particularly amino acid & \\ _aeruginosa_ & substitutions or replacements at codon 170, on carbapenem resistance & OprD \\  & was examined [148]. & \\ \hline _Pseudomonas_ & Investigated the influence of single swaps of amino acid in outer membrane & \\ _aeruginosa_ & proteins on carbapenem resistance strains [149]. & OprD \\ \hline _Pseudomonas_ & The study examined and uncovered that debilitating mutations and decreased & \\ _aeruginosa_ & expression of outer membrane proteins are among the factors that contribute & \\ _aeruginosa_ & to resistance against impenem and meropenem [150]. & \\ \hline _Pseudomonas_ & Showed the existence of membrane proteins in distinct (seventy) clinical & \\ _aeruginosa_ & bacterial isolates resistant to carbapenem [151]. & \\ \hline \hline \end{tabular}
\end{table}