## 1 Introduction
Regarding diabetic wounds, it was shown that the n-butanol fraction of _Cycas thouarsii_ decreased matrix metalloproteinase-9 activity while increasing transforming growth factor \(\beta\)1 (TGF-\(\beta\)1) levels, suggesting that the extract might act both in collagen remodeling and anti-inflammatory action. Thus, even though phytochemicals are known to show exciting biological activities, in many cases, they have not found any therapeutic applicability, since they suffer from rapid metabolism, low bioavailability, poor solubility in water, and instability under physiological conditions [10]. New developments focus on the use of nanotechnology-based delivery systems to deliver phytochemicals and overcome these limitations to their therapeutic efficiency [11]. Nanotechnology solutions provide more efficient wound care due to improved drug solubility, prolonged release, site-specific targeting, and the co-delivery of drugs. Hydrogels, electrospun nanofibers, nanoparticles, and quantum dots have been utilized as effective platforms for the entrapment of phytochemicals [12]. These systems increase cellular uptake and the therapeutic index of active substances while simultaneously protecting them from degradation [13]. Poly(vinyl alcohol)- (PVA) nanofibers incorporated with flaxseed extract exhibited superior wound healing compared to control groups, with a significantly higher wound closure of 97.3% and antimicrobial activity against both Gram\({}^{+}\) and Gram\({}^{-}\) bacteria [14]. Another study showed that rosmarinic-acid-loaded CS/polyethylene oxide nanofibers enhanced \(\alpha\)-smooth muscle actin and elastin expression, thereby expediting wound contraction and supporting tissue regeneration in diabetic mice [13]. Inorganic nanoparticles have also been applied as possible carriers for enhanced wound healing; carbon-based quantum dots are becoming the next-generation nanomaterials for wound care because of their intrinsic antibacterial activity, photostability, and theranostic potential, which surpass even conventional nanoparticles. Moreover, their antibacterial activity is enhanced by functionalization with phytochemicals or doping with elements like sulfur or nitrogen potentially involved in combating MDR microorganisms commonly associated with chronic wound infections [15]. On the one hand, there seems to be a paradigm shift in wound care with the combination of phytotherapy with nanotechnology to provide treatment solutions that acknowledge the intricate wound pathophysiological mechanisms at play. Nevertheless, the clinical validation, regulatory approval, large-scale production, and standardization of these cutting-edge treatments continue to pose challenges [16]. In this context, the aim of this review article is to summarize the most current research findings on nanotechnology-based formulations employing phytochemicals known to provide wound healing properties. A thorough search was conducted on databases such as PubMed(r), ScienceDirect(r), and Google Scholar(r) from 2020 to 2025 using keywords such as wound healing, infections, phytochemical, nanofibers, and nanoparticles. The main inclusion criteria were studies involving the previous terms and especially \"Wound AND Healing OR Infections AND nanoparticles OR nanofibers\". The number of articles retrieved using the main inclusion keywords is shown in Figure 1. In addition, an introductory section about the stages of wound healing is also included so readers can understand how phytochemicals can play a significant role in wound healing. Figure 1: The number of the articles retrieved from searches in (**a**) ScienceDirect®, (**b**) PubMed®, and (**c**) Google Scholar®, using the main inclusion keywords: Wound AND Healing OR Infections AND nanoparticles OR nanofibers between 2020 and 2025.