## 3 Results and Discussion
### Statistical Analysis of the Extracts on Cell Metabolic Activity  
To measure metabolic activity, five repetitions were performed at 100, 20, 10, 5, 1, 0.1, 0.01, and 0.001 mg/mL concentrations using five different extracts: curcumin, goji berry, grape marc and seeds, horsetail, and rosemary. The effect of each extract on the metabolic activity of cells was determined by comparison with the control. No test compound was exposed to cell control. In the control, the cells were exposed only to the medium. Each set of measurements was tested for possible outliers using [PERSON]'s [PERSON]'s statistical tests [98] and in cases where they were present, they were discarded. Average metabolic activities and corresponding standard deviations at different concentrations of extracts are presented in Figure 3. The change in significance in metabolic activity was accessed using a statistical t-test by comparing two sample means at 95% confidence. This test considers the average values at certain concentrations and its standard deviations. The calculated t-value (t\({}_{\text{calc}}\)) is compared with the critical t-values (t\({}_{\text{crit}}\)) and if t\({}_{\text{calc}}>\) t\({}_{\text{crit}}\), the change in average value was considered as significant. The change in bar colors in Figure 3 represents the transition of significant influence on the metabolic activity with the change in concentration. Similar bar color represents an insignificant influence on metabolic activity with change in concentration. Furthermore, in cases where the same metabolic activity was predicted statistically (using the t-test) for more than two samples, non-significant change between these samples was also confirmed by the analysis-of-variances (ANOVA) at 95% confidence. Curcuma extract shows two concentration regions where metabolic activity drops significantly (Figure 3a). The first concentration region is at 0.001-1 mg/mL (MA \(\approx\) 50%), the second at 5-100 mg/mL (MA \(\approx\) 20%). Goji berry extract has the lowest influence on metabolic activity: an insignificant influence of goji berry extract occurred at up to 20 mg/mL (Figure 3b), but a 100 mg/mL concentration had an influence (MA \(\approx\) 20%). In the case of grape marc and seeds extract, a significant influence on metabolic activity occurs at 0.001-5 mg/mL (MA \(\approx\) 70%) (Figure 3c), followed by a second significant drop at 10 mg/mL (MA \(\approx\) 50%). Grape marc and seed extract had the most significant influence at 20-100 mg/mL concentration (MA \(\approx\) 50%). Horsetail extract showed a significant change in metabolic activity even at the lowest concentration present, 0.001 mg/mL (Figure 3d). However, with an increase in the concentration of horsetail extract up to 20 mg/mL, its influence is statistically insignificant. Increasing the concentration from 20 to 100 mg/mL changed metabolic activity significantly again (MA \(\approx\) 20%). Rosemary extract has a different influence on metabolic activity compared with horsetail extract (Figure 3e). In the range of 0.001-1 mg/mL, the effect is similar; it drops at 5 mg/mL, and again drops at 10-20 mg/mL (MA \(\approx\) 20%). The latter concentration has the most significant effect on metabolic activity. Surprisingly, an increase in rosemary concentration to 100 mg/mL increases metabolic activity.