## Appendix C Prompts
Technology&Engineering:Coversawiderangeoftopicsinscience,technology,engineering,and~appliedsciencesthatdonotbelongtoothercategories.This-includesemergingtechnologies(e.g.,AI,IoT,robotics),engineeringdesign,-informationsystems,and~dataanalysis. Whengivenadetailedtopic'sdescriptionand10 randomsampledarticlesbelowthe-topics,choosetheindexnumberofthebestmatchingtopicfromthelist. You[mustonlyreturntheindexnumber]asatstring,noexplanation. \"\"\" user_prompt=f\"\"\" Pleasereadthefollowingtopic'sdescriptionandpaperdetailsunderthetopic,-thendeterminetheindexnumberofthebroaderclassthistopicbelongsto. You[mustonlyreturntheindexnumber]. Topicanddescription:{topic_des} Articles:{text4 emb_list}

```
system_prompt=\"\"\"Youareanintelligentassistantthatspecializesin - refiningandmodifyingtopicdescriptionsbasedongiveninstructions. Yourtaskistocarefullyanalyzetheprovidedtopicanditsdescription - whilepreservingitsoriginalmeaning. Ensurethatthenewlygenerateddescriptionremainsascloseaspossibleto - theoriginalversion,except\"forthespecificmodificationsrequested. \"\"\" user_prompt=f\"\"\" PleaseanalyzethefollowingtopicanditsdescriptionintheformatTopic: - Description. Ifthedescriptioncontainsconcretegeographicallocations(suchas - villagenames,states,provinces,or\"countries),removetheseplace - nameswhileensuringtheremainingcontentremainsmeaningful - and\"coherent. Example 1: AlcoholUseinHIV:ExploringimpactsandpatternsofalcoholuseamongHIV - patientsin Uganda. Ugandaisaconcretecountry'sname,whichshouldberemoved.Thus,you - shouldoutput: AlcoholUseinHIV:Exploringimpactsandpatternsofalcoholuseamong - HIV'patients. Example 2: PalliativeCareAccess:Challengesinopioidavailabilityandcancerpain - managementinlow-incomecountries. Thereisnoconcretegeographiclocationname.Noneedtochange,just - outputtheoriginal-one. Hereistheinputtopicdescription:(topic_des) Youshouldoutputthemodifiedtopicanddescriptionstrictlyinthe - originalformat(Topic:Description). \"\"\"
```

## Appendix D. Partial Mapping From Meso- to Micro-Topics

Cluster 1:

* Pediatric Asthma Management: Focus on improving techniques, adherence, and care outcomes in children with asthma. * Sleep Health: Examines the impact of COVID-19 and lifestyle factors on sleep behaviors and quality. * ICU Delriium: Delriium in ICU patients, its detection, educational, environmental factors, and management strategies. Cluster 2:
* Virtual Reality Assessment: Evaluating cognitive functions using VR technology improves accuracy and ecological validity. * Functional Brain Networks: Examines connections and dynamics of brain regions under various cognitive conditions. * Virtual Patient Training: Utilizing virtual characters to enhance clinical skills in interviewing PTSD patients. Cluster 3:

- Alcohol Use in HIV: Exploring impacts and patterns of alcohol use among HIV patients. - Injection Drug Use: Investigating risks and transmissions among injection drug users in urban environments. - HIV Neurocognitive Disorders: Explores cognitive impairments and disorders among HIV-positive individuals on antiretroviral therapy. Cluster 4:

- Behavioral Weight Loss: Focuses on interventions and strategies to promote weight loss in diverse populations. - Exercise and Health: Impact of aerobic and resistance exercises on health, fitness, and metabolic outcomes. - Postmenopausal Health: Examining weight, diet, metabolic factors impacting heart disease and diabetes post-menopausal. Cluster 5:

- Atrial Fibrillation Genetics: Studies identify genetic factors influencing atrial fibrillation risk and related conditions. - Alzheimer's Disease Diagnosis: Methods and biomarkers improving Alzheimer's diagnosis and understanding cognitive decline patterns. - Pharmacogenomics Prediction: Machine learning predicts drug response in MDD, osteoporosis using genomic, clinical data. Cluster 6:

- Parasite-Host Interactions: Explores ecological and immunological interactions between parasites and hosts impacting evolution and virulence.