## 5 Microarray Results
\begin{table}
\begin{tabular}{l l l l l} \hline \multicolumn{2}{c}{**Gene Symbol**} & \multicolumn{1}{c}{**Description**} & \multicolumn{1}{c}{**Fold Change**} & \multicolumn{1}{c}{_p-Value_} \\ \hline
31 & Abat & 4-aminobutyrate aminotransferase & \(-1.72\) & \(8.88\times 10^{-6}\) \\ \hline
32 & Lcn2 & lipocalin 2 & \(-1.71\) & \(0.0191\) \\ \hline
33 & Olfr1418 & olfactory receptor 1418 & \(-1.71\) & \(0.0208\) \\ \hline
34 & Osr1 & odd-skipped related 1 (Drosophila) & \(-1.7\) & \(9.46\times 10^{-5}\) \\ \hline
35 & Casc4 & cancer susceptibility candidate 4 & \(-1.7\) & \(0.0002\) \\ \hline
36 & Lcmt2 & leucine carboxyl methyltransferase 2 & \(-1.7\) & \(0.0004\) \\ \hline
37 & Sloc2b1 & solute carrier organic anion transporter & \(-1.7\) & \(0.0063\) \\ \hline
38 & Cyp1b1 & cytochrome P450, family 1, subfamily b, & \(-1.69\) & \(4.16\times 10^{-5}\) \\ \hline
39 & Apod & apolipoprotein D & \(-1.69\) & \(0.0002\) \\ \hline
40 & Snora21 & small nucleolar RNA, H/ACA box 21 & \(-1.69\) & \(0.02\) \\ \hline
43 & Arg1 & arginase, liver & \(-1.68\) & \(0.0215\) \\ \hline
41 & Pgap2 & post-GPI attachment to proteins 2 & \(-1.67\) & \(3.44\times 10^{-6}\) \\ \hline
42 & Fmo2 & flavin containing monooxygenase 2 & \(-1.67\) & \(0.0019\) \\ \hline
43 & Gm7697 & predicted gene 7697 & \(-1.66\) & \(0.0011\) \\ \hline
44 & Gm20946 & predicted gene, 20946 [Source:MGI & \(-1.64\) & \(0.0004\) \\ \hline
45 & Hand2 & heart and neural crest derivatives & \(-1.64\) & \(0.0005\) \\ \hline
46 & Lnx1 & ligand of numb-protein X 1 & \(-1.64\) & \(0.0012\) \\ \hline
47 & Gm9495 & predicted gene 9495 & \(-1.63\) & \(0.0004\) \\ \hline
49 & Gcnt1 & glucosaminyl (N-acetyl) transferase 1, core 2 & \(-1.63\) & \(0.0302\) \\ \hline
50 & Ano5 & anoctamin 5 & \(-1.62\) & \(0.0004\) \\ \hline
51 & Ankrd9 & ankyrin repeat domain 9 & \(-1.6\) & \(0.0011\) \\ \hline
52 & Ucp3 & uncoupling protein 3 (mitochondrial, proton carrier) & \(-1.59\) & \(0.0002\) \\ \hline
53 & Gnb3 & guanine nucleotide binding protein (G & \(-1.59\) & \(0.0003\) \\ \hline
54 & Usp17 ld & ubiquitin specific peptidase 17-like D & \(-1.59\) & \(0.0004\) \\ \hline
55 & Gm7265 & predicted gene 7265 & \(-1.59\) & \(0.0152\) \\ \hline
56 & Amy1 & amylase 1, salivary & \(-1.58\) & \(0.0009\) \\ \hline
57 & Gpr22 & G protein-coupled receptor 22 & \(-1.58\) & \(0.016\) \\ \hline
58 & Ttl7 & tubulin tyrosine ligase-like family, member 7 & \(-1.57\) & \(0.0006\) \\ \hline
59 & Mal & myelin and lymphocyte protein, T cell & \(-1.56\) & \(4.18\times 10^{-5}\) \\ \hline
60 & Rasl10b & RAS-like, family 10, member B & \(-1.56\) & \(0.0001\) \\ \hline
61 & Gm7120 & predicted gene 7120 & \(-1.56\) & \(0.0004\) \\ \hline \end{tabular}
\end{table} 
Table 2: _Cont._The differentially regulated 174 genes were subsequently imported into the Ingenuity pathway analysis software (version 24.0.2). The graphical summary IPA is given in Figure 5, which shows several key signaling pathways, out of which the key pathways related to myocardial angiogenesis are VEGF signaling, YAP1 signaling, WNT signaling, IGF signaling, FGF signaling, EGF signaling, EGF signaling, and TLR4 signaling. Also, the in-depth analysis of the genes using the tool network analysis in IPA revealed 13 gene interaction networks. Among these networks, one of the most significant (network 11) is linked to cardiovascular disease. The network exhibited clustering with multiple vital genes, such as ACK3, APLNR, Beta Arrestin, chemokine, EDNRA, Endothelin, estrogen receptor, Focal adhesion kinase, G protein, PI3K (complex), and others. Network 5 concerning cell death and survival included genes such as 26S proteasome, Adaptor protein 1, Ap1, ARG1, BMP4, CCL5, CYP1B1, F Actin, Ficolin-rich granule lumen proteins, FSH, Histone h2a, Histone h3, Histone h4, HLA-A, HSPA1A/HSPA1B, HSPA8, IDH1, IFI16, IFN gamma, IKK (complex), LCMT2, LNX1, MHC CLASS I (family), MTORC1, NFkB (family), P110, p85 (pik3r), PI3K p85, Pkc(s), SCARB2, SERPINA3, STAT5a/b, trypsin, Ubiquitin, and Vegf.