## 1 Introduction  
At the current stage of creating new drugs, more and more attention is paid to medicinal plants. It is important to study medicinal plants that have centuries-old use in scientific and folk medicine and exhibit antimutour activity. Such plants include _Filipendula vulgaris Moench_ (syn. _F. hexapetala_ Gilib., _Filipendula_ Gilib. genus, Rosaceae family), which is native to Europe and north Asia and has been introduced in New York, New Zealand North,New Zealand South, Newfoundland, Primorye, and Vermont [1]. This plant is widely distributed in Ukraine and is used in folk medicine, which allows for industrial harvesting. _F. vulgaris_ is distributed throughout Ukraine, except for the Carpathians, in the steppe and forest-steppe zones. The possibility of plant cultivation has also been investigated [2]. Information on the pharmacological properties of _F. vulgaris_ remains limited, and the study of specific activity, in particular antitumor activity, is important [3; 4; 5]. As a result of phytochemical studies of the above-ground and underground organs of _F. vulgaris_ using chemical and physicochemical methods of analysis, including various types of chromatography, phenolic compounds such as hydroxycinamic acids, flavonoids, glycosides, and tannins, as well as amino acids, fatty acids, carbohydrates, organic acids, and macro- and microelements, were identified [6; 7; 8]. Polyphenols are the main biologically active substances in the raw material of _F. vulgaris_. They play an important role in the implementation of antioxidant, anti-inflammatory, and antitumor activity [3; 4]. The content of flavonoids, such as quercetin and kaempfer and their glycosides, determines the antioxidant potential of the plant [9; 10]. Quercetin helps protect cells from oxidative stress and exhibits antiproliferative activity. Kaempfer is known for its anti-inflammatory properties. The concentration of flavonoids in dry raw material varies within 3.5-4.0%, depending on the environmental conditions. In the composition of _F. vulgaris_, phenolic acids (chlorogenic, caffe, and ferulic acids) were found to make up about 1.8-2.3%. They can inhibit angiogenesis (the formation of new blood vessels necessary for tumour growth). Chlorogenic acid is one of the main phenolic compounds of _F. vulgaris_. It has antioxidant, anti-inflammatory, and antitumor properties. Of particular interest to scientists is its ability to inhibit the growth of hepatocarcinoma cells (HepG2), which is one of the most common and aggressive forms of liver cancer. Chlorogenic acid demonstrates potent antiproliferative activity against hepatocarcinoma cells by inducing apoptosis, blocking proliferation, and reducing oxidative stress and angiogenesis [11; 12; 13]. The tannin fraction of _F. vulgaris_ is represented by hydrolys and condensed tannins. Their content reaches 6-10% in dry mass. They can exhibit antimuour effects through inhibition of tumour signalling pathways and activation of the immune response, effectively inducing apoptosis in lung cancer cells [14; 15; 16]. Extracts of _F. vulgaris_ rhizomes with roots also contain triterpene saponins, which can cause lysis of tumour cell membranes and inhibit their proliferation [16; 17]. Essential oils additionally contribute to the protection of cells from oncogenic factors [4; 14]. The raw material also contains aqueous-soluble polysaccharides (2.5-4.0%), in particular pectins (1.5-2.2%), which regulate the work of the gastrointestinal tract, contributing to the detoxification of the body [18; 19]. Glycans have immunostimulatory activity [20]. Given this composition, it can be assumed that rhizomes with roots of _F. vulgaris_ can exhibit antimuour activity through antioxidant action and modulation of cellular metabolism [3; 4]. Modern oncology requires new effective agents, in particular those of natural origin, which would have minimal toxicity and could be used in combination therapy.