## 6 New Approaches in the Use of Natural Raw Materials in the Treatment of Soriasis  
Based on studies conducted by many researchers, it can be concluded that natural raw materials play a significant role in alleviating the skin symptoms of psoriasis by maintaining normal skin function and structure [80; 81; 82; 83]. Therapy with natural products mainly plays an adjunctive role to primary treatment, and in special cases replaces traditional treatment. [PERSON] et al. in 2023 [82] in their review paper proved that the action of substances that have a positive effect during the treatment of psoriasis can be anti-inflammatory, keratolytic, moisturizing, regenerating, or reducing pruritus. The goal of using antisporiatic preparations is to achieve the PASI (posriasis severity index) score as low as possible. The PASI score refers to an assessment of the area of erythema, severity and type of skin lesions. This measure is aimed at reducing susceptibility to epidermal damage, which consequently reduces the development of psoriasis skin symptoms. In a study conducted by the authors [84], it was shown that the following substances have the most effective therapeutic effect among natural substances for psoriasis: Curcumin amada, Humulus lupulus and Hypericum perforatum. Another natural substance identified by subsequent authors [85] that shows probable effectiveness in the treatment of psoriasis is chamomile (_Matricaria chamonilla_). However, it should be noted that these studies are still in the developmental phase. [PERSON] et al. in 2018 [85] studied the effectiveness of a chamomile-pumpkin oil gel (ChP) applied topically to psoriatic lesions. The oil gel demonstrated efficacy in mild and moderate plaque psoriasis. In the group of patients who applied the oil gel, after 4 weeks from the start of the study, erythema alleviation and skin softening were observed [85]. The anti-inflammatory activity of chamomile is primarily attributed to its flavonoids [86]. Other researchers have shown that chamomile extracts and apigenin, a pure compound derived from chamomile, reduce the cytotoxic activity and proliferation of human T cells, which play a crucial role in chronic wounds and inflammatory skin diseases [87]. Furthermore, chamomile consists of numerous secondary metabolites and active compounds (organic acids, terpen, sesquiterpene lactones, essential oils, coumarin) that positively influence the skin [88]. Topical chamomile poutlices are used to improve skin condition, repair the skin barrier in sores, burns, wounds, ulcers [88]. Chamomile supports granulation processes, which contributes to faster epidermal regeneration. In a study conducted in 2022, scientists analyzing the composition of essential oil derived from chamomile showed its repairing properties and ability to inhibit inflammation in keratinocytes. One of the substances in the composition of chamomile showing anti-inflammatory properties is azulene, which accounts for as much as 88.9% of the oil's composition. When chamomile-derived essential oil was applied to the skin of mice with psoriatic lesions, the lesions were relieved [89]. In another study, researchers showed in a study conducted on rats that chamomile accelerates the healing of ulcers compared to the effects of corticosteroids [90]. Additionally, it exhibits antimicrobial activity, showing mainly fungicidal [91] and bactericidal [92] properties. Thus, it can be concluded that the use of chamomile extract can reduce the risk of infection of damaged skin tissue. Superinfection of psoriatic lesions can lead to the development of more serious dermatoses, so it is reasonable to consider the selection of new potential solutions that will reduce the possibility of such side effects of this disease [88]. A promising natural substance in the treatment of psoriasis is Aloe vera (Aloe vera) [93; 94]. Aloe has been used for the treatment of chronic wounds for many years. It has been proven to be more effective in chronic wounds than in acute ones.