This model suggests that some limits related to dose radiation and contrast medium required in different positional CTA acquisitions can be overcome by the use of this virtual prediction model, above all in the study of dynamic structures like the neck. This study highlights the importance of virtual models in the prediction of some pathological conditions such as ES, which might be otherwise overlooked with standard radiological tools. Further integrations of our virtual prediction model with artificial intelligence and machine learning could help its implementation and the reduction of potential operator-dependent bias when used in routine clinical settings. Figure 2: Patient with Eagle Syndrome in a flexed position of the head. (**A,B**) show a 3D reconstruction model of a patient with Eagle Syndrome in a flexed position of the head (15\({}^{\circ}\)). The model was created from the rest position CTA of the head and neck, applying a virtual bending of 15\({}^{\circ}\). The right styloid process impinges the ipsilateral internal carotid artery tightening its caliber (arrow in (**B**). The enclosed image in (**B**) represents a postero-lateral perspective with a zoomed-out view. (**C**) shows the CTA image of the subject in a flexed position of the head (15\({}^{\circ}\)). The right styloid process impinges the ipsilateral internal carotid artery (arrow). SP = Styloid process; ICA = Internal carotid artery; C2 = C2 Vertebral body. **Supplementary Materials:** The following supporting information can be downloaded at: [[https://www.mdpi.com/article/10.3390/app12094564/s1](https://www.mdpi.com/article/10.3390/app12094564/s1)]([https://www.mdpi.com/article/10.3390/app12094564/s1](https://www.mdpi.com/article/10.3390/app12094564/s1)), Video S1: Dynamic 3D virtual reconstruction model of a CTA of the head and neck in a patient with Eagle Syndrome. **Author Contributions:** Conceptualization, E.N.S., E.M. and S.C.; methodology, E.N.S., E.M. and S.C.; software, S.C.; validation, E.N.S., F.S.D.P., F.G. and S.L.V. ; formal analysis, K.G. and L.C. ; investigation, K.G. and L.C. ; writing--original draft preparation, E.N.S. and E.M.; writing--review and editing, E.N.S. and E.M. All authors have read and agreed to the published version of the manuscript. **Funding:** This research received no external funding. **Institutional Review Board Statement:** The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of the University of Messina (CEME7721--13.7.2021). **Informed Consent Statement:** The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of the University of Messina (CEME7721--13.7.2021). Informed consent was obtained from all subjects involved in the study. **Data Availability Statement:** Not applicable. **Conflicts of Interest:** The authors declare no conflict of interest. Figure 3: Patient with Eagle Syndrome in a right rotation of the head. (**A,B**) show a 3D reconstruction model in a 20\({}^{\circ}\) right rotation of the head. The model was created from the rest position CTA of the head and neck by applying a virtual 20\({}^{\circ}\) right rotation of the head. The right styloid process impinges the ipsilateral internal carotid artery tightening its caliber (arrow in (**B**)). The 3D reconstruction model has been created from the rest position CTA of the head and neck. The enclosed image in (**B**) represents a postero-lateral perspective with a zoomed-out view. SP = Styloid process; ICA = Internal carotid artery; C2 = C2 Vertbral body.