## 2 Materials and Methods
### Interventions and Outcomes  
At the first appointment (T0), patients signed the informed consent. Glycoslated hemoglobin (HbA1c) was measured with a blood sample before each dental procedure. After that, an instructed operator collected the following periodontal indexes by means of a probe (UNC probe 15; Hu-Friedy, Chicago, IL, USA): Probing Pocket Depth (PPD) (measured on six sites per element) [15], Bleeding on Probing (BOP) [13], Bleeding Score (BS) [16], and Plaque Index (PI) [15]. Then, professional oral hygiene was performed with a piezoelectric instrument (Multipiezo, Mectron S.p.a, Carasco, Italy) and Gracey cuttes (Hu-Friedy, Chicago, IL, USA). Ozonized water was administered with the Aquolab(r) professional device (Aquolab s.r.l. EB2C S.r.l, Milano, Italy) using the following parameters: 45\({}^{\circ}\) angulation of the nozzle, 60 s time per site, 12 V tension, and ozone level 3 [16]. Participants received verbal instructions on domiciliary oral hygiene with a soft-bristled electric toothbrush to be used twice a day for 2 min. They were asked to perform a supervised brushing session in front of a mirror under the supervision of the dental hygient to check if a correct brushing technique was used. At this stage, they were randomly assigned into two groups according to the different home treatment: in the trial group, Biorepair Toothpaste and Mousse were used; in the control group, Biorepair Plus Paro-dontgel toothpaste was used. The planned follow-ups were after 3 months from baseline \begin{table}
\begin{tabular}{l l} \hline \hline
**Product** & **Composition** \\ \hline \multirow{4}{*}{Biorepair Peribioma toothpaste} & Aqua, Sorbitol, ZH *, Glycerin, HS, Silica, CB, CG, Aroma, SH, HVLE, SPE, COFE, Bifidobacterium *, Lactobacillus *, Zinc PCA, BA, SB, Phenoxyethanol, SS, Maltotodextrin, Citric Acid, PS, SMS, SMCT, Limonene, Eugenol, CI 77891, CI 16255) \\ \hline \multirow{4}{*}{Biorepair Peribioma Mousse mouthwash} & Aqua, Sorbitol, Xylitol, ZH *, Aroma, Pistacia Lenticus (Mastic) Gum Oil, Lactobacillus *, Bifidobacterium *, SH, Ascorbic Acid, HVLE, SPE, COFE, TA, RP, Eucalyptus Globulus Leaf Oil, PEG-40 Hydrogenated Castor Oil, Phenoxyethanol, SB, CB, Glycerin, Maltodextrin, SB, Helianthus Annus Seed Oil, PS, BHT, Limonene, CI 16255. (* microRepair® BIOMA) \\ \hline \multirow{4}{*}{Biorepair Parodontgel Plustoothpaste} & Aqua, ZH \({}^{\dagger}\), Glycerin, Sorbitol, HS, Silica, CB, CG, Aroma, Lactoferrin, SMS, SMCT, HVLE, SPE, COFE, Zinc PCA, SH, TA, RP, SS, Phenoxyethanol, BA, SB, PS, Limonene, CI 77891. \\ \hline \multirow{4}{*}{Biorepair Peribioma Mousse mouthwash} & Legend: ZH, Zinc Hydroxyapatite; CB, Cocamidopropyl Betaine; CG, Cellulose Gum; SH, Sodium Hyluronate; HVLE, Hamamells Virginia Leaf Extract; SPE, Spirulating Plateus Extract; COFE, Calendula Officials Flower Extract; SB, Sodium Benzoate; SS, Sodium Sacchurin; PS, Potassium Sorbate; SMCT, Sodium Methyl Cocoyl Taurate; HS, Hydrated Silica; SMS, Sodium Myristoyl Sacrosiastic; BA, benzyl alcohol; TA, Tcocopherly Acetate; RP, Retinyl Palmitate; * microRepair® BIOMA; * microRepair®. \\ \hline \end{tabular}
\end{table} 
Table 1: Materials used in the study and their compositions [12; 13].