## 2 Materials and Methods
### Chemistry
mp 158.0-159.0 \({}^{\circ}\)C; \({}^{1}\)H (500 MHz, MeOD) \(\delta\) ppm 8.40 (s, 1H), 7.94 (d, \(J\) = 9.1 Hz, 1H), 7.36 (dt, \(J\) = 8.7, 2.8 Hz, 2H), 7.21-7.16 (m, 2H), 7.711 (dd, \(J\) = 9.1, 2.6 Hz, 1H), 7.08 (d, \(J\) = 2.5 Hz, 1H), 3.93 (s, 3H), 3.83 (t, \(J\) = 7.4 Hz, 2H), 3.05 (t, \(J\) = 7.4 Hz, 2H). \({}^{13}\)C (125 MHz, MeOD) \(\delta\) ppm 163.5, 159.6, 155.0, 150.6, 147.7 (q, \(J\) = 1.7 Hz), 138.7, 130.1, 123.5, 120.7, 120.6(2-Methylquinazolin-4-yJ)[2-4-(trifluoromethyloormethoxy)phenyllethylamine, **24a**  
Following general procedure A, using 4-chloro-2-methylquinazoline (**24**, 100 mg, 0.56 mmol), 2-[4-(trifluoromethyloormethoxy)phenyl]ethylamine (115 mg, 0.56 mmol), and potassium carbonate (77 mg, 0.56 mmol) gave **24a** as a pale yellow solid (153 mg, 79%). mp 124.4-127.2 \({}^{\circ}\)C; \({}^{1}\)H (500 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 7.81 (d, \(J\) = 8.3 Hz, 1H), 7.74-7.68 (m, 1H), 7.60 (d, \(J\) = 8.1 Hz, H), 7.42-7.37 (m, 2H), 7.20 (d, \(J\) = 8.0 Hz, 2H), 5.91 (br.s, 1H), 3.96 (dt, \(J\) = 6.9, 6.0 Hz, 2H), 3.07 (t, \(J\) = 7.0 Hz, 2H), 2.69 (s, 3H). \({}^{13}\)C (125 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 164.3, 159.3, 149.4, 148.0 (q, \(J\) = 1.7 Hz), 137.8, 132.7, 130.2, 127.5, 125.3, 121.2, 120.5 (q, \(J\) = 256.9 Hz), 120.3, 112.8, 42.2, 34.7, 26.5. \({}^{19}\)F (470 MHz, CDCl\({}_{3}\)) \(\delta\) ppm \(-\)57.9 (s, 3F). HRMS (EI), M + 1 calculated for C\({}_{18}\)H\({}_{16}\)F\({}_{3}\)N\({}_{3}\)O, 348.1318, found 348.1335. (2-Cyclopropylquinazolin-4-yl)[2-[4-(trifluoromethyloormethoxy)phenyl]ethyl]amine, **25a**  
Following general procedure A, using 4-chloro-2-cyclopropylquinazoline (**25**, 100 mg, 0.49 mmol), 2-[4-(trifluoromethyloormethoxy)phenyl]ethylamine (100 mg, 0.49 mmol) and potassium carbonate (67 mg, 0.48 mmol) gave **25a** as a tan solid (119 mg, 65%). mp 205.1-205.5 \({}^{\circ}\)C; \({}^{1}\)H (500 MHz, MeOD) \(\delta\) ppm 8.24 (d, \(J\) = 8.5 Hz, 1H), 8.02-7.97 (m, 1H), 7.74-7.68 (m, 2H), 7.36 (dt, \(J\) = 8.6, 2.7 Hz, 2H), 7.20 (d, \(J\) = 7.8 Hz, 2H), 3.99 (t, \(J\) = 7.1 Hz, 2H), 3.08 (t, \(J\) = 7.1 Hz, 2H), 2.23-2.16 (m, 1H), 1.44-1.32 (m, 4H). \({}^{13}\)C (125 MHz, MeOD) \(\delta\) ppm 166.5, 160.8, 147.9, 138.3, 137.9, 135.7, 130.2, 127.7, 123.3, 120.9, 120.5 (q, \(J\) = 255.2 Hz), 118.0, 111.9, 42.9, 33.8, 14.5, 11.2. \({}^{19}\)F (470 MHz, MeOD) \(\delta\) ppm \(-\)59.6 (s, 3F). HRMS (EI), M + 1 calculated for C\({}_{20}\)H\({}_{18}\)F\({}_{3}\)N\({}_{3}\)O, 374.1475, found 374.1493. (7-Fluoro-2-methylquinazolin-4-yl)[2-[4-(trifluoromethyloormethoxy)phenyl]ethyl]amine, **26a**  
Following general procedure A, using 4-chloro-7-fluoro-2-methylquinazoline (**26**, 75 mg, 0.37 mmol), 2-[4-(trifluoromethyloormethoxy)phenyl]ethylamine (77 mg, 0.37 mmol), and potassium carbonate (52 mg, 0.37 mmol) gave **26a** as a white solid (58 mg, 43%). mp 121.7-124.7 \({}^{\circ}\)C; \({}^{1}\)H (500 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 14.78 (s, 1H), 10.62 (s, 1H), 9.10 (dd, \(J\) = 9.1, 5.2 Hz, 1H), 7.84 (dd, \(J\) = 8.6, 2.4 Hz, 1H), 7.30-7.22 (m, 1H), 7.19-7.13 (m, 2H), 7.06-7.02 (m, 2H), 4.14 (q, \(J\) = 6.9 Hz, 2H), 3.22 (t, \(J\) = 7.4 Hz, 2H), 2.77 (s, 3H). \({}^{13}\)C (125 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 166.1 (d, \(J\) = 259.4 Hz), 162.0, 160.0, 149.3 (q, \(J\) = 2.0 Hz), 140.7, 140.5 (d, \(J\) = 12.9 Hz), 129.8, 128.7 (d, \(J\) = 10.3 Hz), 127.4, 121.4, 120.4 (q, \(J\) = 257.1 Hz), 119.1, 116.9 (d, \(J\) = 23.9 Hz), 108.6, 104.7 (d, \(J\) = 25.6 Hz), 43.1, 34.6, 22.4. \({}^{19}\)F (470 MHz, CDCl\({}_{3}\)) \(\delta\) ppm \(-\)57.8 (s, 3F), \(-\)98.3 (ddd, \(J\) = 4.8, 8.1, 8.1 Hz, 1F). HRMS (EI), M + 1 calculated for C\({}_{18}\)H\({}_{15}\)F\({}_{4}\)N\({}_{3}\)O, 366.1224, found 366.1199.