## 4 Materials and Methods
### Experimental Data
#### 4.3.5 Products **3A**  
Isolated yield of four diastereomers (isomers 1, 2, 3, 4 in a 12:7:6:5 ratio) of **3A** was 51%. White solid. Isomer 1 of **3A** (7-(\(R\)) 8-(\(R\))):  
\({}^{1}\)H-NMR (500 MHz, MeOD): \(\delta\) (ppm) = 6.87 (d, \(J\) = 1.6 Hz, 1 H, H-2'), 6.81 (d, \(J\) = 2.0 Hz, 1 H, H-2), 6.78 (d, \(J\) = 8.2 Hz, 1 H, H-5), 6.69 (dd, \(J\) = 8.2, 2.0 Hz, 1 H, H-6), 6.68-6.69 (m, 2 H, H-5' and H-6'), 5.33 (br. s, 1 H, H-7), 4.20 (dd, \(J\) = 5.3, 1.0 Hz, 1 H, H-8'), 3.81 (s, 3 H, OMe), 3.79 (s, 3 H, OMe), 2.93-2.96 (m, 2 H, H-7'ab), 2.84-2.88 (m, 1 H, H-8'). \({}^{13}\)C-NMR (125 MHz, MeOD): \(\delta\) (ppm) = 179.7 (9'), 149.3, 148.8, 147.6, 145.9, 132.0, 129.5, 122.3, 118.4, 116.4, 116.1, 113.7, 109.6, 88.8, (7), 75.6 (8), 56.4 (OMe), 56.3 (OMe), 46.6 (8'), 30.0 (7'). HRMS: found 359.1143 (M\({}^{-}\)). C\({}_{19}\)H\({}_{19}\)O\({}_{7}\)\({}^{-}\) requires 359.1136. Isomer 2 of **3A** (7-(5) 8-(R)):  
\({}^{1}\)H-NMR (500 MHz, MeOD): \(\delta\) (ppm) = 6.97 (d, \(J\) = 0.7 Hz, 1 H, H-2\({}^{\prime}\)), 6.90 (d, \(J\) = 1.9 Hz, 1 H, H-2), 6.80 (m, 2 H, H-5\({}^{\prime}\) and H-6\({}^{\prime}\)), 6.75 (dd, \(J\) = 8.0, 1.9 Hz, 1 H, H-6), 6.71 (d, \(J\) = 8.0 Hz, H-5), 5.31 (d, \(J\) = 2.8 Hz, 1 H, H-7), 4.26 (dd, \(J\) = 4.5, 2.8 Hz, 1 H, H-8), 3.86 (s, 3 H, OMe), 3.83 (s, 3 H, OMe), 3.14 (ddd, \(J\) = 11.0, 4.5, 3.9 Hz) 3.00 (dd, \(J\) = 13.9, 3.9 Hz, 1 H, H-7\({}^{\prime}\)a), 2.94 (dd, \(J\) = 13.9, 11.0 Hz, 1 H, H-7\({}^{\prime}\)b). \({}^{13}\)C-NMR (125 MHz, MeOD): \(\delta\) (ppm) = 180.0 (9\({}^{\prime}\)), 148.9 (3\({}^{\prime}\)), 148.8 (3), 147.7 (4\({}^{\prime}\)), 146.0 (4), 132.4 (1\({}^{\prime}\)), 127.4 (1), 122.3 (6), 121.0 (6\({}^{\prime}\)), 116.2 (5), 115.8 (5\({}^{\prime}\)), 113.6 (2), 111.9 (2\({}^{\prime}\)), 86.0 (7), 72.8 (8), 56.4 (OMe), 56.3 (OMe), 51.1 (8\({}^{\prime}\)), 30.2 (7\({}^{\prime}\)). HRMS: found 359.1143 (M\({}^{-}\)). C\({}_{19}\)H\({}_{19}\)O\({}_{7}\)\({}^{-}\) requires 359.1136. Isomer 3 of **3A** (7-(R) 8-(S)):  
\({}^{1}\)H-NMR (500 MHz, MeOD): \(\delta\) (ppm) = 6.83 (d, \(J\) = 1.9 Hz, 1 H, H-2\({}^{\prime}\)), 6.65-7.75 (m, 4 H, H-5, H-6, H-5\({}^{\prime}\), H-6\({}^{\prime}\)), 6.51 (d, \(J\) = 2.0 Hz, 1 H, H-2\({}^{\prime}\)) 4.93 (d, \(J\) = 7.2 Hz, 1 H, H-7), 4.06 (dd, \(J\) = 8.6, 7.2 Hz, 1 H, H-8), 3.80 (s, 3 H, OMe), 3.71 (s, 3 H, OMe), 3.11 (dd, \(J\) = 13.7, 4.3, 1 H, H-7\({}^{\prime}\)a), 2.99 (ddd, \(J\) = 8.6, 5.7, 4.3 Hz, 1 H, H-8\({}^{\prime}\)), 2.93 (dd, \(J\) = 13.7, 5.7 Hz, 1 H, H-7\({}^{\prime}\)b). \({}^{13}\)C-NMR (125 MHz, MeOD): \(\delta\) (ppm) = 178.1 (9\({}^{\prime}\)), 149. 2 (3\({}^{\prime}\)), 148.9 (3), 148.2 (4\({}^{\prime}\)), 146.4 (4), 130.4 (1\({}^{\prime}\)), 130.0 (1), 123.4 (6), 121.0 (6\({}^{\prime}\)), 116.1 (5), 115.9 (5\({}^{\prime}\)), 114.3 (2), 110.3 (2\({}^{\prime}\)), 86.8 (7), 77.7 (8), 56.3 (OMe), 56.3 (OMe), 51.4 (8\({}^{\prime}\)), 33.1 (7\({}^{\prime}\)). HRMS: found 359.1143 (M\({}^{-}\)). C\({}_{19}\)H\({}_{19}\)O\({}_{7}\)\({}^{-}\) requires 359.1136. Isomer 4 of **3A** (7-(S) 8-(S)):  
\({}^{1}\)H-NMR (500 MHz, MeOD): \(\delta\) (ppm) = 6.90 (d, \(J\) = 0.9 Hz, 1 H, H-2\({}^{\prime}\)), 6.89 (d, \(J\) = 1.9 Hz, 1 H, H-2\({}^{\prime}\)), 6.79 (d, \(J\) = 8.1 Hz, 1 H, H-5), 6.76 (m, 2 H, H-5\({}^{\prime}\) and H-6\({}^{\prime}\)), 6.74 (dd, \(J\) = 8.1, 1.9 Hz, 1 H, H-6), 5.32 (d, \(J\) = 4.4 Hz, 1 H, H-7\({}^{\prime}\)), 4.28 (dd, \(J\) = 4.4, 2.4 Hz, 1 H, H-8),3.86 (s, 3 H, OMe), 3.84 (s, 3 H, OMe), 3.02 (dd, \(J\) = 13.9, 5.7 Hz, 1 H, H-7\({}^{\prime}\)a), 2.96 (dd, \(J\) = 13.9, 8.2 Hz, 1 H, H-7\({}^{\prime}\)b), 2.90 (ddd, \(J\) = 8.2, 5.7, 2.4 Hz, 1 H, H-8\({}^{\prime}\)). \({}^{13}\)C-NMR (125 MHz, MeOD): \(\delta\) (ppm) = 180.4 (9\({}^{\prime}\)), 149.1 (3), 148.8 (3\({}^{\prime}\)), 147.8 (4\({}^{\prime}\)), 146.6 (4), 130.6 (1\({}^{\prime}\)), 127.0 (1), 122.7 (6\({}^{\prime}\)), 120.9 (6), 116.3 (5), 115.9 (5\({}^{\prime}\)), 113.7 (2\({}^{\prime}\)), 111.9 (2), 85.5 (7), 74.4 (8), 56.4 (OMe), 56.4 (OMe), 53.1 (8\({}^{\prime}\)), 34.3 (7\({}^{\prime}\)).