## 2 Materials and Methods  
Relevant literature was obtained from scientific databases such as TCMSP ([[https://old.tcmsp-e.com/tcmsp.php](https://old.tcmsp-e.com/tcmsp.php)]([https://old.tcmsp-e.com/tcmsp.php](https://old.tcmsp-e.com/tcmsp.php)), accessed on 21 April 2023), Pubchem ([[https://pubchem.ncbi.nlm.nih.gov](https://pubchem.ncbi.nlm.nih.gov)]([https://pubchem.ncbi.nlm.nih.gov](https://pubchem.ncbi.nlm.nih.gov)), accessed on 23 April 2023), Scientific Database of China Plant Species ([[http://db.kib.ac.cn](http://db.kib.ac.cn)]([http://db.kib.ac.cn](http://db.kib.ac.cn)), accessed on 10 April 2023), Google Scholar ([[https://xs.scqylaw.com](https://xs.scqylaw.com)]([https://xs.scqylaw.com](https://xs.scqylaw.com)), accessed on 5 April 2023), PubMed ([[https://pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov)]([https://pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov)), accessed on 5 April 2023), Baidu Scholar ([[https://xueshu.baidu.com](https://xueshu.baidu.com)]([https://xueshu.baidu.com](https://xueshu.baidu.com)), accessed on 3 April 2023), Vip site (China Science and Technology Journal Database) ([[http://www.cqirp.com](http://www.cqirp.com)]([http://www.cqirp.com](http://www.cqirp.com)), accessed on 3 April 2023), and CNKI site (Chinese National Knowledge Infrastructure) ([[https://www.cnki.net](https://www.cnki.net)]([https://www.cnki.net](https://www.cnki.net)), accessed on 3 April 2023). The most extensive collection of publicly available chemical data in the world is found on PubChem. Chemicals can be found using their names, structures, molecular formulas, and other identifiers. Discover information about biological activity, safety and toxicity, chemical and physical qualities, patents, literature citations, et al. The PubChem Compound, Substance, and Bioassay sub-databases are the three sub-databases that make up the PubChem database. TCMSP, which includes 499 Chinese herbal medicines, a total of 29,384 ingredients, 3311 targets, and 837 related diseases. TCMSP is a unique systematic pharmacology platform for Chinese herbal medicines, where we can find the relationship between drugs, targets, and diseases. This database platform provides information that includes identifying active ingredients, compounds, drug target networks, et al. [17]. The Database of China Plant Species is jointly constructed by the Kunming Institute of Botany, Chinese Academy of Sciences (KIB), the Institute of Botany, Chinese Academy of Sciences (IBS), the Wuhan Botanical Garden, Chinese Academy of Sciences (WBG), and the South China Botanical Garden, Chinese Academy of Sciences (SCBG). There are more than 31,000 species of higher plants in more than 3400 genera in more than 300 families, and the data content mainly includes standard names of plant species, basic information, systematic taxonomic information, ecological information, physiological and biochemical characteristic description information, habitat and distribution information, literature information, and other information. TCMSP, Pubchem, and Web of Huayuan were used to find the chemical composition of _T. chinensis_. Most of the active components were obtained by searching for _T. chinensis_ in TCMSP. Then, PubChem and Web of Huayuan were used to obtain and validate information related to the chemical structure of organic small molecules contained in the herb and their biological activities. The Web of China Plant Species Information Database is the primary source for the botanical collection of the genus _Tollius_. All the sites listed above are public databases and have access to the public database. The article is summarized using other websites that gather literature about the development of _T. chinensis_ research. Diverse studies have been published in recent years. Therefore, a comprehensive review is necessary. This paper reviewed the research progress of _T.