This has driven scientists to develop new materials, with the most well-known nanocarriers being linear block amphiphilic copolymers. These were first used in the 1980s for the formation of micelles in solution [7]. This type of nanoparticle allowed for the improvement of the solubility of lipophilic drugs that are poorly soluble in water, as well as an increase in their efficacy and bioavailability [8]. Linear polymers have also been able to form other types of smart nanocarriers that are responsive to stimuli, carrying chemical entities sensitive to various conditions such as light, pH, temperature, etc [9]. Linear polymers, despite their advantages, have always been limited by their low encapsulation capacity and high micellar concentration; furthermore, the resulting micelles are only able to encapsulate one type of drug, whether it is hydrophobic or hydrophilic [10]. These limitations have prompted researchers to explore new strategies to enhance the efficiency of drug encapsulation and optimize the performance of drug delivery systems based on amphiphilic copolymers. Several approaches have been developed recently, such as the use of smart linear polymers, modification of micelle structures, or the combination of multiple types of polymers to improve drug encapsulation capacity. These advances have opened up new perspectives in the field of drug delivery, offering new options for the treatment of various diseases [11; 12; 13; 14]. Scientific research has further evolved towards designing new non-linear architectures of copolymers [15], including star [16], comb [17; 18], brush [19; 20], and hyperbranched structures such as dendrimers [21; 22]. This diversity in architecture has overcome certain limitations in drug delivery by personalizing nanoparticles with greater precision. These structures have unique physical and chemical properties that make them attractive for use in drug delivery systems [23]. Dendrimers, for instance, possess a highly branched, tree-like structure that provides precise control over their size and surface properties [24]. They can be functionalized with a variety of molecules, making them ideal for targeted drug delivery. Similarly, star, comb, and brush copolymers have unique structural features that make these types of polymers suitable for drug delivery applications. These architectures have a high degree of branching, which provides a large number of functional groups on their surface. This enables the copolymers to encapsulate and deliver drugs with greater efficiency and to target specific tissues or cells in the body [25]. In addition to offering unique physical and chemical properties, multi-arm copolymers have advantages over traditional linear copolymers in terms of mechanical stability and controlled drug release [26]. The high degree of branching in these structures provides mechanical stability [27; 28], which allows them to withstand the harsh conditions of the body's environment. Moreover, the tunable surface chemistry of these structures allows for the controlled release of drugs over a specified period, which is essential for effective drug therapy [29; 30]. Polymer science has played an important role in this advancement, enabling a better understanding of the pharmacokinetic behavior of branched architecture-based nanoparticles and their progression in in vitro and in vivo evaluations [31; 32; 33]. Among the various materials used for the fabrication of nanoparticles, polycaprolactone (PCL) has gained considerable attention due to its biodegradability [34; 35], biocompatibility [34; 36; 37], and ease of synthesis [38; 39]. Multi-arm architectures based on PCL have been explored in recent years as a strategy to enhance the drug delivery efficiency of nanoparticles [40; 41]. The multi-arm architecture offers several advantages over linear and dendritic polymers, such as increased stability, improved drug loading, and enhanced cellular uptake [42].