# Anti-Breast Cancer Activity of Essential Oil:
## 3 Result
### Bioactivity of Essential Oils as Anti-Breast Cancer Agents  
Essential oils have been widely studied to treat breast cancer. From the articles collected, it is known that compounds that act as cancer agents are mostly terpene and its derivatives (Table 1). \begin{table}
\begin{tabular}{p{42.7 pt} p{113.8 pt} p{113.8 pt} p{113.8 pt} p{113.8 pt}} \hline \hline
**No** & **Plant Name** & **Compounds** & **Methods** & **Activities** & **Ref.** \\ \hline
1 & _Zataria multifora_ & Monoterpenes and triterpenes & MCF-7 and MDA-MB-231 cells & Triggers apoptosis by inducing ROS, mitochondrial membrane potential (MMP) & [93] \\ \hline
2 & _Zataria multifora_ & Monoterpenes & In vitro using 4T1 cells & Inhibition of proliferation and apoptosis of 4T1 and TC1 cells. & [94] \\ \hline
3 & _Cymbopogon citratus_ & Monoterpenes & In vivo using 54 [PERSON] female rats & Shows tumor reduction as well as necrosis and mitosis. & [95] \\ \hline
4 & _Oliveria decumbens_ & Monoterpenes & In vitro using 4T1 cells & Induces apoptosis through ROS generation, mitochondrial membrane potential disruption, caspase-3 activation, and DNA damage. & [38] \\ \hline
5 & _Pinus sylvetris_ & Monoterpenes & In vitro using MCF-7 cells & Inhibits the growth of MCF-7 cells by 45.3\% and 99.7\%. & [96] \\ \hline
6 & _Eryhrina corallodendron L._ & MonotMonoterpenes & In vitro using MDA-MB-231, MCF-7 and H\(\mathrm{\mu}\)L cells & Inhibits the proliferation, migration, and invasion of breast cancer cells in a dose-dependent manner. & [97] \\ \hline
7 & _Cyphotsemma jutta_ & Diterpenes & In vitro using MDA-MB 231 and MDA-MB 231 and SUM 149 cells & _C. jutta_ oil substantially reduces the activation of NF-kB transcription factors, resulting in a significant decrease in several NF-kB target genes. & [98] \\ \hline
8 & _Juniperus oxycedrus_ & Monoterpenes & In vitro using MCF-7 cells & ALEO shows an IC\({}_{50}\) value of 31\% (v/v) against MCF-7 cells after 36 h of treatment. & [99] \\ \hline
9 & _Pallines spinosa_ & Monoterpenes and triterpenes & In vitro using MCF-7 and MDA-MB-231 cells & Induces apoptosis in MCF-7 and MDA-MB-231 cell lines, and alters Bcl-2 and Bax protein levels. & [60] \\ \hline  & oleo-gum-resin and its essential oil of _Ferula_ & & The results show that the three constituents can inhibit the proliferation of 4T1 cells. & \\  & _assa-foetida_ and & Monoterpenes & In vitro 4T1 cells & Our MTT assay results demonstrated a significant cytotoxicity effect in a time and concentration-dependent manner. & [100] \\ \hline
11 & _Deactropis bicolor_ (Zucc.) & Monoterpenes & In vitro using MDA MB 231 cells & Cytotoxic effect on MDA-MB-231 cells in a dose- and time-dependent manner with an IC\({}_{50}\) of 53.81 \(\pm\) 1.691 \(\mu\)g/mL, but independent of the breast epithelial cell line MCF10A (207.51 \(\pm\) 3.26 \(\mu\)g/mL). & [101] \\ \hline
12 & _Cimamomom longepanicultatum_ & Monoterpenes & A549 and MCF-7 cells & The essential oil derived from C. longepanicultatum with the main compounds of terpinen-4-ol, \(\alpha\)-terpineol, and safrole induces apoptosis or substantial necrosis in human A549 lung cancer and MCF-7 breast cancer cells. & [61] \\ \hline \hline \end{tabular}
\end{table} 
Table 1: Bioactivity of Essential Oils as Anti-Breast Cancer Agent.