## 3 Results  
The results are presented as Mean \(\pm\) S.D. of the different measured variables. The percentage increase or decrease was also presented within the same tables. Table 1 presents the concentrations of brain serotonin, dopamine, and glutamate as three important brain neurotransmitters. While serotonin and glutamate were not affected by the three nutritional interventions, dopamine was significantly elevated in response to the combined effects of MPE and CRE (\(p\) < 0.025). Table 2 demonstrates the anti-inflammatory effects of the independent and combined MPE and CRE. It can be easily noticed that there was significantly lower IL-12 in all groups (\(p<0.005\)) compared to controls, and only a significantly lower IL-6 in the MPE + CRE combined-treated group (\(p<0.028\)). Table 3 demonstrates the concentrations of serum leptin in control, MPE, CRE and synergistically-treated rats. It was clear that the three dietary interventions induced remarkably lower levels of leptin with the combined treatment, in which it recorded a significantly lower level compared to healthy control group. Levels of malondialdehydedehyde (MDA) and GSH as markers of oxidative stress and antioxidant capacity were considerably improved with the combined treatment of MPE + CRE, in which it recorded a tendency to significance at \(p<0.071\) and \(0.06\), respectively (Table 4). \begin{table}
\begin{tabular}{c c c c c} \hline
**Parameters** & **Groups** & **Mean \(\pm\) S.D.** & **Percent Change** & \(p\) **Value** \\ \hline \multirow{6}{*}{\(\mathrm{(IL12)}\) pg/mL} & Control & \(77.40\pm 14.50\) & \(100.00\) & \multirow{6}{*}{\(0.111\)} \\  & MPE & \(64.20\pm 2.17\) & \(-17.05\) & \(0.111\) \\ \cline{1-1}  & CRE & \(80.60\pm 13.32\) & \(+4.13\) & \(0.726\) \\ \cline{1-1}  & MPE + CRE & \(62.40\pm 16.04\) & \(-19.38\) & \(0.159\) \\ \cline{1-1}  & Control & \(34.60\pm 11.37\) & \(100.00\) & \multirow{6}{*}{\(0.345\)} \\ \cline{1-1} Dopamin & MPE & \(40.40\pm 5.46\) & \(+16.76\) & \(0.345\) \\ \cline{1-1} \cline{2-5}  & CRE & \(43.40\pm 11.55\) & \(+25.43\) & \(0.259\) \\ \cline{1-1}  & MPE + CRE & \(57.20\pm 14.36\) & \(+65.32\) & \(0.025\) \\ \cline{1-1}  & Control & \(36.20\pm 8.79\) & \(100.00\) & \multirow{6}{*}{\(0.584\)} \\ \cline{1-1} Glutamate & MPE & \(38.60\pm 3.36\) & \(+6.63\) & \(0.584\) \\ \cline{1-1} \cline{2-5}  & CRE & \(36.20\pm 6.72\) & \(100.00\) & \multirow{6}{*}{\(1.000\)} \\ \cline{1-1}  & MPE + CRE & \(42.60\pm 8.62\) & \(+17.68\) & \(0.278\) \\ \hline \end{tabular}
\end{table} 
Table 1: Levels of brain serotonin, dopamine, and glutamate neurotransmitters in the control, independent MPE- or CRE-treated groups, and the combined-treated group. \begin{table}
\begin{tabular}{c c c c c} \hline
**Parameters** & **Groups** & **Mean \(\pm\) S.D.** & **Percent Change** & \(p\) **Value** \\ \hline \multirow{6}{*}{\(\mathrm{(IL12)}\) pg/mL} & Control & \(44.14\pm 6.68\) & \(100.00\) & \multirow{6}{*}{\(0.028\)} \\  & MPE & \(34.50\pm 5.20\) & \(-21.83\) & \(0.034\) \\ \cline{1-1}  & CRE & \(35.14\pm 3.46\) & \(-20.39\) & \(0.028\) \\ \cline{1-1}  & MPE + CRE & \(34.86\pm 3.75\) & \(-21.03\) & \(0.027\) \\ \cline{1-1}  & Control & \(84.50\pm 6.22\) & \(100.00\) & \multirow{6}{*}{\(0.362\)} \\ \cline{1-1}  & MPE & \(81.17\pm 4.55\) & \(-3.94\) & \(0.362\) \\ \cline{1-1}  & CRE & \(85.59\pm 4.30\) & \(+1.30\) & \(0.754\) \\ \cline{1-1}  & MPE + CRE & \(76.02\pm 3.40\) & \(-10.13\) & \(0.028\) \\ \hline \end{tabular}
\end{table} 
Table 2: Levels of serum IL-12 and IL-6 in the control, independent MPE or CRE, and the combined-treated rats. is a table. Tables should be placed in the main text near to the first time they are cited.