# PolySorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy
## 5 PS-Coated NPs for Efficient BBB Transport
\begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Drug** & **Therapeutic** & **Diseases** & **Surface** & **Study Model** & **Reference** \\ \hline PCBA & Dalargin & Analgesic & PS 80 & In vivo mice & [113] \\ PCBA & Dalargin & Analgesic & PS 80 & In vivo mice & [115] \\ PCBA & Dalargin & Analgesic & PS 80 & In vivo mice & [120] \\ PCBA & Malaysian & Analgesic & PS 80 & In vivo mice & [125] \\ PCBA & Rivastigmine & Alzheimer & PS 80 & Wistar rats & [126] \\ \multirow{2}{*}{PLA} & FITC- & \multirow{2}{*}{BBB} & \multirow{2}{*}{PS 80} & In vivo Kunming & \multirow{2}{*}{[132]} \\  & dextran & & & & \\ \multirow{4}{*}{PLGA} & \multirow{4}{*}{Acetylpuerarin} & Cerebral & \multirow{4}{*}{PS 80} & In vivo Wistar & \multirow{4}{*}{[133]} \\  & & ischaemi- & & & \\ \multirow{4}{*}{PCBA} & \multirow{4}{*}{Gemcitabine} & \multirow{4}{*}{Glioblastoma} & \multirow{4}{*}{PS 80} & In vivo rats & \multirow{4}{*}{[134]} \\  & & & & & In vivo white & \\ \multirow{4}{*}{PCBA} & \multirow{4}{*}{Doxorubicin} & \multirow{4}{*}{Glioblastoma} & \multirow{4}{*}{PS 80} & male non-inbred & \multirow{4}{*}{[135]} \\  & & & & & \\ \multirow{4}{*}{PLA-b-PEG} & \multirow{4}{*}{Amphotericin} & \multirow{4}{*}{Cryptococcal } & \multirow{4}{*}{PS 80} & In vivo BALB/c & \multirow{4}{*}{[136]} \\  & & B & Meningitis & & mice & \\ \multirow{4}{*}{Iron oxide} & \multirow{4}{*}{Curcumin} & Brain & \multirow{4}{*}{PS 80} & \multirow{4}{*}{Sprague\(-\)Dawley} & \multirow{4}{*}{[137]} \\  & & targeting & & & & \\ \multirow{4}{*}{PBCA} & \multirow{4}{*}{Curcumin} & Targeting & \multirow{4}{*}{PS 80} & In vitro B.End3 & \multirow{4}{*}{[138]} \\  & acid & & & & & \\ \multirow{4}{*}{PBCA} & \multirow{4}{*}{Fluorophore} & \multirow{4}{*}{Brine target-} & \multirow{4}{*}{PS 80} & \multirow{4}{*}{In vivo mice} & \multirow{4}{*}{[139]} \\  & and anti-A\(\beta\) & & & & \\ \multirow{4}{*}{PLGA} & antibody & & detection & & \\ \multirow{4}{*}{PLGA} & Methotrexate- & Brain cancer & PS 80 & In vivo & \multirow{4}{*}{[140]} \\  & transferrin & & & & \\ \multirow{4}{*}{PLGA} & \multirow{4}{*}{Thymoquinone} & Alzheimer & PS 80 & In vivo & \multirow{4}{*}{[141]} \\  & & & & & \\ \multirow{4}{*}{PLGA} & \multirow{4}{*}{siRNA} & Traumatic & \multirow{4}{*}{PS 80} & In vivo & \multirow{4}{*}{[142]} \\  & brain injury & & & & C57 BL/6] mice & \\ \hline \hline \end{tabular}
\end{table} 
Table 1: Various PS-coated NPs for brain-targeted delivery. PS 80-coated redox-sensitive micelles were fabricated using hydrophilic hyaluronic acid-conjugated curcumin through disulfide linkers [138]. The micelles were coated with PS 80 to achieve effective brain targeting. The PS 80-coated redox-sensitive micelles exhibited redox sensitivity in the presence of glutathione. CD44 is a cell surface hyaluronic acid-binding glycoprotein that is overexpressed in cancer cells. Therefore, cellular uptake of hyaluronic acid-curcumin conjugates encapsulated into PS 80-coated redox-sensitive micelles was higher than that of free curcumin in CD44 receptor-expressing G422 glioblastoma cells. The increased cellular internalization of PS 80-coated redox-sensitive micelles incorporating curcumin induced higher cytotoxicity against G422 cells than free curcumin [138]. The redox-sensitive micelles also exhibited high plasma stability and did not induce hemolysis in erythrocytes. PS 80-coated PBCA NPs were developed for the delivery of brain-impermeable imaging agents into the brain. The results showed that PS 80-coated PBCA NPs delivered imaging agents into the brain of mice for in vivo imaging of neuronal and glial nuclei. Neuropathological changes in neurodegenerative diseases can be visualized using NPs. Notably, BBB-permeable NPs did not induce nonspecific disruption of the BBB [139]. PS 80-coated PLGA NPs loaded with methotrexate-transferrin conjugates were developed for efficient BBB migration [140]. Figure 9 shows the BBB crossing details in the pictorial view.