###### Abstract
Several studies reported that 49.9% of the samples collected in ambulances were positive for bacteria and that 0.9% were highly drug-resistant pathogenic strains: Methicillin-Resistant _Staphylococcus aureus_ (MRSA); methicillin-resistant coagulase-negative staphylococci (MRCoNS); and carbapenemase-producing _Klebsiella pneumoniae_ (KPC) [15]. In a study of 21 ambulances, 47.6% of swabs were confirmed positive for MRSA [16]. Contamination by a large number of microbes was also found in helicopter air ambulances [17], also confirmed by detailed data obtained in an Australian study [18]. Another study in four ambulances showed that \"four of the seven isolated species were substantial nosocomial pathogens and three of these four possess formidable patterns of antibiotic resistance\" [19]. These data are also confirmed in rural ambulances, where 49% tested positive in at least one internal point for MRSA contamination [20]. Furthermore, Gram-negative coliforms are commonly present including _Enterobacter, Klebsiella_ and _Escherichia_[21]. The same study shows that the number of contaminated sites inside an ambulance increases from 57% to 86% after cleaning and disinfection. Regular and priority disinfection inside the ambulance should therefore be carried out on items frequently handled by paramedics who may be at greater risk of contamination. This type of contamination is applicable also to SARS-CoV-2 considering recent studies that have measured the persistence on surfaces [22]. Respiratory droplets and aerosol particles exhaled during the speech of infected people have a crucial role in the spread of the infection [23; 24]. According to several studies virus stability and persistence on surfaces of common use such as plastic, glass, stainless steel, wood, paper, copper and cloth [3; 4; 25; 26] seems to be influenced by the characteristics of the different materials but also by environmental conditions such as temperature, pH and humidity [4; 8; 27; 28]. The 254 nm wavelengths of the UVC light exerts bactericidal and virucidal effects, and it is widely used in the environmental disinfection of enclosed spaces [29]. In fact, UVC light induces chemical modifications of nucleic acids, blocking the replication mechanisms [30]. Different studies demonstrated the rapid inactivation by UVC irradiation of pathogens, also of SARS-CoV-2 on droplet nuclei of bioaerosols and on surfaces and supplies [31; 32; 33; 34; 35; 36; 37]. During the COVID-19 pandemic period, in addition to the cleaning processes already in place, various sanitization solutions were implemented based on the use of surgical medical aids and biocidal substances. In all cases, sanitation is an operation that interrupts the ambulance service and requires the intervention of operators. In the light of the above, the efficient and rapid disinfection of surfaces may have an important role in the containment of the pandemic. In addition, the need to trace the sanitization carried out has become increasingly pressing to meet regulatory needs. In this context, an advanced UltraViolet SANitizing System (UV-SAN) was developed and integrated into an ambulance, capable of guaranteeing high levels of sanitation, and that can be used several times during the day. The system is equipped with a remote control and a traceability system exploits the germicidal effect of the UVC radiation at 254 nm to sanitize the patient's compartment of ambulances.