## 3 Results
### Results of Statistical Correlation between Brain-Volume and pASL
#### 3.2.1 Patients with FTD  
Of the 43 brain regions, five displayed good linear correlation of significant brain atrophy and a reduced CBF--in two cases, additionally rCBF--of the pASL data. The significant results for FTD patients can be summarized as follows:  
We observed a good positive correlation between brain volume and CBF/rCBF for the left STG ([PERSON]'s rho = 0.900, \(p\) = 0.037). The right IFWMO demonstrated very good correlation between CBF and volume (Pearson = 0.968, \(p\) = 0.007; [PERSON]'s rho = 0.900, \(p\) = 0.037). After having excluded one patient with negative pASL values, the merged observation of both thalami showed good positive correlation of CBF/rCBF data with brain volume (CBF: Pearson = 0.810, \(p\) = 0.015; [PERSON]'s rho = 0.810, \(p\) = 0.015; Kendall Tau-b = 0.643, \(p\) = 0.026; rCBF: Pearson = 0.722, \(p\) = 0.043). Ultimately, there was good positive linear correlation between volume and CBF for the right EC ([PERSON]'s rho = 0.900, \(p\) = 0.037). For exemplary imagery, see Figure 4. \begin{table}
\begin{tabular}{l c c c} \hline \hline
**Brain Region of Interest** & **Mean Volume in FTD (in mm\({}^{3}\))** & **Mean Volume in CO (in mm\({}^{3}\))** & **Level of Significance (\(p\))** \\ \hline MFG-DPFC left & 9525.6 & 11,480.0 & 0.053 \\ MFG-DPFC-right & 9763.6 & 11,947.1 & 0.031 \\ IFGO left & 2755.0 & 3347.1 & 0.023 \\ IFGO right & 2062.2 & 2622.6 & 0.002 \\ MROG right & 3534.4 & 4028.0 & 0.041 \\ RG left & 3770.2 & 4625.9 & 0.026 \\ RG right & 3747.6 & 4691.5 & 0.006 \\ STG left & 9212.4 & 11,653.5 & 0.004 \\ STG right & 8948.2 & 10,913.4 & 0.004 \\ STG-pole left & 4168.4 & 5227.8 & 0.013 \\ AG left & 5866.8 & 6770.3 & 0.048 \\ SOG left & 2051.2 & 2395.6 & 0.030 \\ Insula left & 5104.8 & 6127.6 & 0.038 \\ Insula right & 5202.0 & 6141.0 & 0.024 \\ Amygdala left & 1071.8 & 1497.9 & 0.000 \\ Amygdala right & 1217.2 & 1630.7 & 0.006 \\ Hippocampus left & 2868.4 & 3442.0 & 0.022 \\ Putamen left & 2886.0 & 3684.6 & 0.001 \\ Putamen right & 3152.0 & 3876.3 & 0.002 \\ GP left & 1124.2 & 1340.4 & 0.025 \\ Thalamus left & 4468.4 & 5237.5 & 0.034 \\ Thalamus right & 4668.8 & 5348.7 & 0.041 \\ NucAccumbens right & 604.6 & 730.8 & 0.049 \\ Snigra left & 261.0 & 318.8 & 0.026 \\ Snigra right & 210.8 & 256.3 & 0.048 \\ CP left & 1536.2 & 1858.2 & 0.026 \\ CP right & 1623.4 & 1916.5 & 0.050 \\ ICP left & 631.4 & 761.0 & 0.036 \\ SCR left & 13,355.8 & 15,739.9 & 0.044 \\ PCR left & 5040.6 & 6124.4 & 0.013 \\ PCR right & 4243.2 & 5156.5 & 0.036 \\ EC left & 2514.0 & 2862.1 & 0.034 \\ EC right & 2433.0 & 2821.2 & 0.035 \\ IFO left & 1534.8 & 1765.8 & 0.024 \\ IFO right & 1561.2 & 1787.8 & 0.024 \\ SS right & 3210.8 & 4012.9 & 0.009 \\ CI right & 264.2 & 374.7 & 0.003 \\ Basal Forebrain left & 462.6 & 536.5 & 0.044 \\ IFWMO left & 1818.8 & 2283.6 & 0.008 \\ IFWMO right & 1543.2 & 1881.6 & 0.010 \\ Caudate–tail left & 273.4 & 338.1 & 0.030 \\ Caudate–tail right & 253.8 & 347.0 & 0.022 \\ Fimbria right & 16.4 & 36.5 & 0.011 \\ \hline \hline \end{tabular} Note: FTD indicates frontotemporal dementia; CO, control subjects.  
\end{table} 
Table 2: Significant atrophy in brain regions of interest—FTD vs. CO.  
Figure 2: Significant atrophy of regions for FTD compared to CO (control)—volumes in mm\({}^{3}\): (a) left: STG; (b) left SOG; (c) left thalamus; (d) right thalamus; (e) left EC; (f) right EC. \begin{table}
\begin{tabular}{l c c c} \hline \hline
**Brain Region of Interest** & **Mean Volume in AD (in mm3)** & **Mean Volume in CO (in mm3)** & **Level of Significance (\(p\))** \\ \hline STG right & 9516.6 & 10,913.4 & 0.056 \\ SOG right & 1916.4 & 2465.6 & 0.008 \\ Hippocamp right & 2873.0 & 3510.2 & 0.025 \\ CGH right & 1182.6 & 1456.6 & 0.036 \\ MTWM right & 7245.6 & 8682.2 & 0.045 \\ Caudate-tail left & 259.4 & 338.1 & 0.013 \\ \hline \hline \end{tabular} Note: AD indicates Alzheimer’s disease; CO, control subjects.  
\end{table}