## 4 Discussion
While this inherent constraint introduces potential vendor-specific bias, we mitigated analytical influences through blinded assessment protocols and independent processing pipelines. Furthermore, we limited our study and analyses to a specific set of MRI acquisition and reconstruction parameters. We acknowledge that our results also inherently depend on the selection of these parameters. Thirdly, we limited our analysis to subjective image quality and subjective evaluation of anatomical structures. Diagnostic accuracy was not assessed due to the very limited number of subjects presenting with relevant/pathological imaging findings. Moreover, we did not evaluate objective image quality of the sequences. However, it should be noted that conventional ROI-based signal-to-noise ratio (SNR) metrics can be compromised by the inherent denoising algorithm of CS- and CS-AI-based technologies, where the regional distribution of noise within the image may inherently vary [36]. In conclusion, our findings demonstrate that DL-powered SSR can enhance imaging performance by introducing flexibility in T2w hippocampal imaging, either by improving image quality in non-accelerated scans or by maintaining acceptable quality in accelerated scans, with the added benefit of reduced scan times. Futures studies should evaluate the impact of SSR on diagnostic performance. Conceptualization, T.S., A.A., T.H., A.M. and S.S.-S.; data curation, T.H. ; formal analysis, E.S. and S.S.-S.; investigation, T.S. ; methodology, E.S., T.S., C.A.B. and S.S.-S.; resources, A.A., T.H. and C.A.B. ; software, T.S. and T.H. ; supervision, A.-A., M.M. and C.A.B. ; validation, T.S. ; writing--original draft, T.S. and S.S.-S.; writing--review and editing, E.S., T.H., A.M., M.M. and C.A.B. All authors have read and agreed to the published version of the manuscript. This research received no specific external funding. The study was conducted in accordance with the Declaration of Helsinki and had full IRB approval from our ethics committee (BASEC, Canton Zurich of Switzerland); Approval Number: BASEC 2019-00259; Approval Date: 4 July 2019. Informed Consent Statement: Informed consent was obtained from all subjects involved in the study. The data presented in this study are available on reasonable request to the corresponding author. During the preparation of this work the author(s) used ChatGPT (version GPT-4) and DeepSeek (version DeepSeek-R1) in order to improve readability, spelling, and grammar. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the publication. Author [PERSON] was employed by the company Philips Healthsystems. The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: [PERSON] reports that financial support was provided by Philips Healthcare Switzerland. [PERSON] reports that financial support and equipment, drugs, or supplies were provided by Philips Healthcare Switzerland. [PERSON] reports that financial support was provided by Philips Healthcare Switzerland. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.