## 7 Applications
Experimental extraction parameters affecting the efficiency and repeatability of the extraction were optimized. Optimized conditions included cellulose fabric coated with a sol-gel polyethylene glycol sorbent and back extraction using ACN-MeOH (80:20 \(v/v\)) mixture. Limits of quantification (LOQs) ranged between 0.03 and 0.3 ng mL\({}^{-1}\). Relative recoveries ranged from 77 \(\pm\) 6% to 118 \(\pm\) 4%, and from 87 \(\pm\) 4% to 121 \(\pm\) 6% for red and white wines, respectively. The applicability of the method was proved for commercial wines. In 2019, [PERSON] et al. [40] developed and validated an innovative fabric phase sorptive extraction high-performance liquid chromatography-diode array detection (FPSE-HPLC-DAD) method for the extraction of five common antidepressants (venlafaxine, paroxetine, fluoxetine, amitriptyline, clomipramine) in human urine samples. The extraction protocol was optimized with regards to the extraction main parameters. Sol-gel graphene sorbent, coated on cellulose FPSE media, were the most efficient among other with different polarities using CH\({}_{3}\)OH:CH\({}_{3}\)CN (50:50 \(v/v\)) for back-extraction. The absolute recovery values were 25.5% for venlafaxine, 33.9% for paroxetine, 67.0% for fluoxetine, 43.0% for amitriptyline, and 29.0% for clomipramine, while relative recoveries were higher than 90%. The developed method provides satisfactory limit of detection 0.15 ng/mL. [PERSON] in 2019 [41] proposed a fabric phase sorptive extraction based method prior to high-performance liquid chromatography-photodiode array detection (FPSE-HPLC-PDA) for the simultaneous extraction and analysis of six benzophenone derivative UV filters, including benzophenone (BZ), 5-benzoyl-4-hydroxy-methoxybenzenesulfonic acid (BP-4), bis(4-hydroxyphenyl)methananone (4-DHB), bis(2,4-dihydroxyphenyl)methanone (BP-2), (2,4-dihydroxybenzophenone) (BP-1), and 2,2\({}^{\prime}\)-dihydroxy-4-methoxybenzophenone (DHMB) in human whole blood, plasma, and urine samples. The limit of quantification was found to be 0.1 ug/mL. This new approach shows promising results with high potential for direct adaptation as a rapid, robust, and green analytical tool for several applications, e.g., in the current sample preparation practices used in many bioanalytical fields including pharmacokinetics (PK), pharmacodynamics (PD), therapeutic drug monitoring (TDM), clinical and forensic toxicology, disease diagnosis, and drug discovery. Optimized conditions included the use of sol-gel CW@20M FPSE membrane with a 20:80 (% \(v\):\(v\)) mixture of phosphate buffer 40 mM at pH 3 and methanol. [PERSON] et al. in 2019 [42] reported a metabolomics workflow using a mass spectrometry-compatible fabric phase sorptive extraction (FPSE) technique implementing a matrix coated with sol-gel poly(caprolactone-b-dimethylsiloxane-b-caprolactone) that binds both polar and nonpolar metabolites in whole blood, eliminating serum processing steps. FPSE preparation technique combined with liquid chromatography-mass spectrometry can distinguish radiation exposure markers such as taurine, carnitine, arachidonic acid, \(\alpha\)-linolenic acid, and oleic acid found 24 h after 8 Gy irradiation. These findings suggest that the FPSE approach could work in future technology to triage irradiated individualsaccurately, via biomarker screening, by providing a novel method to stabilize biofluids between collection and sample analysis. [PERSON] et al. in 2019 [43] proposed an environmentally friendly method by making use of high-performance liquid chromatography and photo-diode array detection (HPLC-PDA) for the determination of four penicillin antibiotics residues (benzylpenicicillin, coloxacillin, dicloxacillin, and oxacillin) in human blood serum after FPSE. Solvent evaporation and reconstitution steps, which are considered to be rather time-consuming, were eradicated successfully from the sample preparation workflow, organic solvent consumption was brought to a minimum, while protein precipitation was assessed as impractical.