## 4 Valorization of Agricultural By-Products Using DESs
\begin{tabular}{c} **Sample** \\ **(Amount)** \\ \end{tabular}  } & \multirow{2}{*}{**Biositive Compound**} & \multirow{2}{*}{** \begin{tabular}{c} **DES** \\ **Moaler Ratio Amount** \\ **Water Content** \\ \end{tabular} } & \multirow{2}{*}{**Extraction Procedure**} & \multirow{2}{*}{**Analytical Technique**} & \multirow{2}{*}{**Extraction Efficiency**} & \multirow{2}{*}{**Comments**} & \multirow{2}{*}{**Ref. **} \\ \cline{4-4} \cline{6-10}  & & & & & & & & & & \\ \hline \multirow{4}{*}{_Agelic membrane_ Back pulp} & 10 phenolic acids, 6 flavonoidsids and (c)trainamide acid & ChClCloxide acid (r/r) & & & & & & & & \\  & & & & & & & & & & \\  & & & & & & & & & & \\  & & & & & & & & & & \\  & & & & & & & & & & \\  & & & & & & & & & & \\  & & & & & & & & & & \\  & & & & & & & & & & \\  & & & & & & & & & & \\ \hline \multirow{4}{*}{_Agelic membrane_ Back pulp} & 10 phenolic acids, 6 flavonoidsids and (c)trainamide acid & ChClCloxide acid (r/r) & & & & & & & & \\  & & & & & & & &  
\begin{table}
\begin{tabular}{c c c c c c c c c c} \hline \hline \multicolumn{1}{c}{**Sample**} & \multicolumn{1}{c}{**DIS**} & \multicolumn{1}{c}{**Extraction Procedure**} & \multicolumn{1}{c}{**Analytical Technique**} & \multicolumn{1}{c}{**Extraction Efficiency**} & \multicolumn{1}{c}{**Comments**} & \multicolumn{1}{c}{**Ref. **} \\ \cline{2-10} **(Announ)** & **Biosactive Compound** & **Molar Ratio: Amount** & **Water Content** & & & & & - & Totalphenol index was & \\  & & & & & & & & & - & Other HIDS were evaluated: \\ \hline Hoplkmac dive leaves & & ChCl  
\begin{table}
\begin{tabular}{c c c c c c c c} \hline \hline
**Sample** & \multicolumn{3}{c}{**DES**} & \multicolumn{3}{c}{**Extraction Procedure**} & **Analytical Technique** & **Extraction Efficiency** & **Comments** & **Ref. ** \\ \hline
**Sample** & **Biactive Compound** & **Molecular Ratio Amount** & **Extraction Procedure** & **Analytical Technique** & **Extraction Efficiency** & **Comments** & **Ref. ** \\ \hline
**Using criteria** & & & & & & & \\
**Cargebruitl peps** & **Polyphenols** & **Lactic acidglucose** & **HVDED, SLE** & **HPLC-DAD** & - & **Directed DBs** were tested. & [3]  
Regarding the type of DES applied in this area, the use of ChCl-based NADESs has been the most extended combined with different types of HBDs, although combinations of lactic acid and glucose also have demonstrated their suitability for the extraction of phenolic and acidic compounds [35; 36]. In those works, in which the nature of the DES was evaluated, results demonstrated the relevance of the type of DES on the extraction performance, as well as the activity of the obtained extracted. An exhaustive study in this sense was developed by [PERSON] et al. [33]. In this case, the authors evaluated the influence of the HBD (i.e., carboxylic acid, polyol and amide) components in ChCl-based NADESs on the UAE of phenolic acids and flavonoids from Sapodilla pulp (natural chewing gum from _Manilkara zapota_ tree), as well as on the storage stability, radical-scavenging and antimicrobial properties of the extracts. Results indicated a larger extraction yield for acid HBDs due to the lower pH and higher polarity of the resulting DESs which favored their interaction with phenolic compounds and provided extraction efficiency higher than for conventional acetone/water (5/5, \(v/v\)) solvent. Moreover, it was observed that the higher viscosity of DESs with respect to conventional solvents, which reduced air incorporation, and the H-bonding interaction of polyphenols with DESs, allow further stability of the extracts when acid-based DESs were applied. Antioxidant activity resulted in agreement with the extraction capacity of the evaluated DESs. Therefore, the higher activity was found for oxalic-based NADES that was also the one with the highest extraction efficiency. With respect to antimicrobial activity, the authors found that in this case both the phenolic content and the solvent provided antimicrobial capacity, independently.