## 4 Discussion  
One of the most serious corneal injuries is burns. Chemical injury of the eye may produce extensive damage to the ocular surface epithelium, cornea, and anterior segment, resulting in permanent visual impairment. Immediately following chemical injury, it is important to estimate and clinically grade the severity of limbal stem cell injury and intraocular penetration of the noxious agent [11]. Immediate therapy is directed toward prompt irrigation and removal of any remaining reservoir of chemical contact with the eye. Initial medical therapy is directed at promoting re-epithelialization and transdifferentiation of the ocular surface, augmenting corneal repair by supporting keratocyte collagen production and minimizing ulceration related to collagenase activity, and controlling inflammation [19]. At the 1-month follow-up, it was found that systemically transplanted MSCs could implant into the injured cornea to accelerate wound healing through differentiation, proliferation, and synergy with hematopoietic stem cells [20]. Human limbal niche cells (LNC) or bone-marrow-derived mesenchymal stem cells (BMMSC) were used to prevent limbal stem cell deficiency (LSCD) in an alkali burn rabbit model, and their results were compared. In contrast to the control group, the severity of LSCD in both the LNC and BMMSC transplantation groups was dramatically reduced as shown by smaller epithelial cell defects, decreased fluorescein sodium staining, decreased neovascularization, and decreased goblet cell density. Interestingly, the LNC group was shown to more effectively prevent LSCD than the BMMSC group [21]. The effect of cultured human adipose tissue-derived stem cells on the regeneration of the rabbit cornea after alkaline chemical burn was studied, using human adipose tissue-derived stem cells as the source material. Immediately after the chemical burn, the experimental eye received a single subconjunctival injection of a stem cell suspension. Transplantation of cultured human adipose tissue-derived stem cells as a treatment for chemical corneal burn was found to promote cell renewal and help repair damage to the rabbit cornea [22]. Acute phase treatment includes a broad spectrum topical antibiotic, cycloplegic, and antiglaucoma therapy [23]. Oral treatment with doxycycline was found to be very effective in preventing corneal angiogenesis and inflammation of alkali-burned corneas [24]. Positive results in oxidative disorder management have been achieved with tear supplements, particularly based on hyaluronic acid, topically administered corticosteroids, and prophylactic antibiotic use. Chemically modified and cross-linked hyaluron gels improved corneal wound healing after alkali injury in rabbits. The wound closure rate and thickness of the corneal epithelium in eyes treated with hyaluron gel were significantly greater than in untreated injured eyes. Acceleration of corneal healing can occur after administration of low-molecular organic compounds [6]. High solution of retinol palmitate to treat corneal damage with \(n\)-heptanol. \begin{table}
\begin{tabular}{c c c} \hline \hline  & **Study Group** & **Control Group** \\ \hline Homogenate & 19.2 \(\pm\) 3.6 & 15.2 \(\pm\) 2.8 \\ Solcosenyl & 20.4 \(\pm\) 4.3 & 13.9 \(\pm\) 3.5 \\ \hline \hline \end{tabular}
\end{table} 
Table 3: Mean corneal anterior epithelial thickness (\(\upmu\)m) measured by histo-pathology 9 weeks after corneal injury. However, effective treatment required eye drops six times a day at a dose of over 1000 mU/mL. At the same time, complete healing of the cornea was observed on the 12 th day after the damage. [PERSON] et al. [7]. showed that a polysaccharide fraction isolated from tamarind (_Tama-rindus indica_ L.) seeds slightly but significantly increased the wound healing rate caused by surface alcohol damage. [PERSON] et al. examined the effect of antioxidants (allopurinol and acetylcysteine) and corticosteroids (prednisolone acetate) in eye drops in the healing of corneal alkali burns [25].