## 4 Results
### Comparison between FC and IPLFCS
\begin{table}
\begin{tabular}{l c c c c c c c c c} \hline  & \multicolumn{4}{c}{**Cohort 1**} & \multicolumn{4}{c}{**Cohort 2**} \\ \cline{2-10}  & **NC** & **SCD (61)** & **MCI** & **AD** & **\(p\) Value** & **NC** & **MCI** & **AD** & **\(p\) Value** \\  & **(91)** & **SCD (61)** & **MCI** & **AD** & **(13)** & **\(p\) Value** & **NC** & **MCI** & **AD** & **\(p\) Value** \\ \hline Age & \multirow{2}{*}{\(65.5\pm 5.7\)} & \multirow{2}{*}{\(66.7\pm 5.9\)} & \multirow{2}{*}{\(66.9\pm 8.4\)} & \multirow{2}{*}{\(71.4\pm 8.9\)} & \multirow{2}{*}{\(0.204\) b} & \multirow{2}{*}{\(72.0\pm 5.9\)} & \multirow{2}{*}{\(71.6\pm 5.5\)} & \multirow{2}{*}{\(71.3\pm 7.2\)} & \multirow{2}{*}{\(74.0\pm 7.8\)} & \multirow{2}{*}{\(0.560\) b} \\ (years) & & & & & & & & & \\ \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\(12.5\pm 3.0\)} & \multirow{2}{*}{\(12.8\pm 2.7\)} & \multirow{2}{*}{\(10.6\pm 3.9\)} & \multirow{2}{*}{\(11.5\pm 4.2\)} & \multirow{2}{*}{\(0.488\) b} & \multirow{2}{*}{\(16.2\pm 2.2\)} & \multirow{2}{*}{\(16.9\pm 2.5\)} & \multirow{2}{*}{\(16.0\pm 2.7\)} & \multirow{2}{*}{\(14.9\pm 2.5\)} & \multirow{2}{*}{\(0.035\) b,*} \\  & & & & & & & & & \\ \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\(38/53\)} & \multirow{2}{*}{\(12/49\)} & \multirow{2}{*}{\(19/25\)} & \multirow{2}{*}{\(3/10\)} & \multirow{2}{*}{\(0.004\) a,*b} & \multirow{2}{*}{\(59/81\)} & \multirow{2}{*}{\(32/43\)} & \multirow{2}{*}{\(100/105\)} & \multirow{2}{*}{\(45/49\)} & \multirow{2}{*}{\(0.941\) a} \\  & & & & & & & & & \\ \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\(22/14\)} & \multirow{2}{*}{-} & \multirow{2}{*}{-} & - & - & \multirow{2}{*}{\(0.555\) a} & \multirow{2}{*}{\(45/19\)} & \multirow{2}{*}{\(31/19\)} & \multirow{2}{*}{-} & \multirow{2}{*}{-} & \multirow{2}{*}{\(0.350\) a} \\  & & & & & & & & & & \\ \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\(2.8\pm 3.8\)} & \multirow{2}{*}{\(5.3\pm 1.7\)} & \multirow{2}{*}{\(6.4\pm 6.8\)} & \multirow{2}{*}{\(4.7\pm 5.7\)} & \multirow{2}{*}{\(0.044\) b,*b} & \multirow{2}{*}{-} & - & - & - & - \\ \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\(3.3\pm 2.2\)} & \multirow{2}{*}{\(5.3\pm 4.5\)} & \multirow{2}{*}{\(5.0\pm 4.9\)} & \multirow{2}{*}{\(4.5\pm 4.4\)} & \multirow{2}{*}{\(0.002\) b,*b} & \multirow{2}{*}{-} & - & - & - & - \\ SCD-9 & & & & & & & & & \\ \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\(3.5\pm 2.2\)} & \multirow{2}{*}{\(5.3\pm 1.7\)} & \multirow{2}{*}{\(2.0\pm 1.8\)} & \multirow{2}{*}{\(2.8\pm 0.8\)} & \multirow{2}{*}{\(<\)} & \multirow{2}{*}{\(<\)} & \multirow{2}{*}{-} & - & - & - & - \\ MMSE & \(28.9\pm 1.4\) & & & & & & & & & \\ \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\(28.9\pm 1.3\)} & \multirow{2}{*}{\(26.0\pm 2.7\)} & \multirow{2}{*}{\(17.0\pm 5.3\)} & \multirow{2}{*}{\(0.861\) b} & \multirow{2}{*}{\(28.7\pm 4.6\)} & \multirow{2}{*}{\(29.0\pm 0.9\)} & \multirow{2}{*}{\(27.3\pm 2.5\)} & \multirow{2}{*}{\(21.1\pm 3.5\)} & \multirow{2}{*}{\(0.119\) b} \\  & & & & & & & & & \\ \multirow{2}{*}{\
\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\(7.5\pm 1\)} & \multirow{2}{*}{\(7.1\pm 1.9\)} & \multirow{2}{*}{\(3.8\pm 2.4\)} & \multirow{2}{*}{\(0.9\pm 0.4\)} & \multirow{2}{*}{\(0.248\) b} & \multirow{2}{*}{-} & - & - & - & - \\ \multirow{2}{*}{
\begin{tabular}{} \end{tabular} } & \multirow{2}{*}{\(22.4\pm 1.5\)} & \multirow{2}{*}{\(22.4\pm 1.4\)} & \multirow{2}{*}{\(19.7\pm 2.6\)} & \multirow{2}{*}{\(15.7\pm 2.6\)} & \multirow{2}{*}{\(0.881\) b} & \multirow{2}{*}{-} & - & - & - & - \\ \hline \end{tabular}
\end{table} 
Table 1: Demographic characteristics. Figure 2: Group comparison between NC and SCD in brain regions. (**a**) Comparison of FC between group; (**b**) Comparison of IPLFCs between group; (**c**) Differential brain regions were found by the between-group comparison of IPLFCS but not in the between-group comparison of FC. Z value represents the \(z\)-axis of standard space.