## 1 Introduction  
Conventional implant surgery involves incisions of the alveolar mucosa and elevation of the mucoperiosteal flap to visualise and access the bone. This approach ensures the identification and protection of the underlying vital anatomical structures: vessels, nerves, or the maxillary sinus [1, 2]. Insufficient bone in the regions to be treated with implants requires prior bone regeneration. The materials involved in bone augmentation can be classified as autogenous (grafts taken directly from the patient's tissues), allogenic (human bone material), xenogenic (derived from animals), or alloplastic (synthetic or natural provenance) [3]. Recently, an autogenous bone substitute extracted from the appropriately processed dentin of retained teeth has been successfully used to meet biological and physical criteria [4; 5]. In the case of reduced alveolar bone, elevation of the full-thickness or partial-thickness flap results in loss of bone mass and increased osteoclast activity [6], which further aggravates the local anatomical conditions [7; 8]. In extreme cases, it can lead to complications, such as injury to the inferior alveolar nerve or nasopalatine nerve and the perforation of the nasal cavity or the maxillary sinus, including accidental migration of a dental implant into the sinus [9; 10]. Recently, surgical navigation techniques have been developed that provide safety, aesthetics, and comfort with a minimally invasive surgical method and are well accepted among both doctors and patients [11]. Navigation can be divided into static (using templates) and dynamic surgical navigation. The use of dynamic navigation techniques does not require the use of preprepared templates. Digital planning helps to optimise the position of the implant, taking into account the requirements for future prosthetic restoration. The accurate tracking of the position of each instrument in the surgical field by the navigation system allows for high precision in restricted anatomical conditions, shorter duration, and better outcomes regarding the procedure performed, along with less patient exposure to the procedure-related risks of infection, pain, and stress [12; 13]. Researchers are attempting to objectively assess the body's response to a range of conditions, not only systemic, such as systemic lupus erythematosus (SLE), tuberculosis, or malignant processes [14; 15], but also oral conditions, including periodontitis [16], caries [17; 18], lichen planus [19], or peri-implantitis [20]. To this end, the levels of various cytokines, such as IL-18, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IFN-\(\gamma\), TNF-\(\alpha\), and CRP, are monitored for diagnostic and prognostic purposes, and their fluctuations are reflected in the patient's clinical condition or to assess the severity of the disease [21; 22]. Cytokine concentrations can be assessed in body fluids, tissues, and cells [23], and recently, human saliva has been more widely used [24]. In comparison to blood, saliva collection is a non-invasive procedure, does not involve nursing personnel, and does not evoke negative associations. Therefore, saliva sampling is especially suitable in cases where blood sampling is difficult, e.g., in very small children, the elderly, or anxious individuals [25; 26]. Inflammatory mediators can affect leukocyte, osteoblast, and osteoclast activity and promote systemic and local tissue remodelling [27; 28]. The frequently assessed biomarkers of inflammation are CRP and IL-6, and clinical use has been confirmed in studies [29; 30]. Interleukin-6 (IL-6) is a pleiotropic cytokine involved in multiple inflammatory responses, with roles in immune regulation [31] and pathological conditions, including both acute and chronic inflammatory diseases [32]. IL-6 initiates and up-regulates inflammation, triggers the release of acute phase proteins, regulates the inflammatory response, attracts immune cells to sites of injury or infection, and stimulates coagulation [33].