## 5 Conclusions  
The antioxidant capacity of the tested anti-aging creams varies depending on the type of extract and the method used for its determination. Although the DPPH method is applicable to both types of extracts, it is not the most suitable method for determining the antioxidant capacity in anti-aging creams. The reason for this is that the measurements for this method are carried out in the part of the spectrum in which the plant pigments commonly contained in these creams absorb. The Folin-Ciocalteu method is suitable for testing the antioxidant capacity of hydrophilic extracts, while lipophilic extracts should be avoided due to the occurrence of turbidity and the formation of a gelled ring. FRAP provided similar results for all the samples and proved to be a less sensitive method compared to the other methods, mainly due to the lower reactivity of ferro ions compared to the more sensitive DPPH and ABTS radicals. The ferroion chelation method with ferroise, similar to the DPPH method, takes measurements in the part of the spectrum where plant pigments interfere, making this method unsuitable for determining the antioxidant capacity in anti-aging creams. Furthermore, it was not possible to determine the antioxidant capacity of the lipophilic cream extracts using this method. As the antioxidant content in these creams is low, more sensitive methods are better suited for determining the antioxidant capacity in these samples. The ABTS method for both types of extracts has proven to be the most suitable method for determining the antioxidant capacity.  
The advantage of in vitro methods for testing antioxidant activity is reflected by the fact that they can be used to separately determine the antioxidant capacity in hydrophilic and lipophilic cream extracts, which is not possible with in vivo methods. The disadvantage of these in vitro methods is that they cannot fully predict how these topical products will exhibit antioxidant activity in a living organism, as well as that the results are affected by the complexity of the matrix. From all of the tested methods, only the ABTS method proved to be suitable for the in vitro testing of the antioxidant activity of this type of topical preparation. The method was sufficiently sensitive, selective, rapid and furthermore adequate for the in vitro estimation of the efficacy of this type of product in a control analytical laboratory. However. a combination of the in vitro method and the in vivo method would provide the best insight into the antioxidant activity of these products, which could be the next aim in researching the antioxidant capacity of anti-aging creams in the future.  
Conceptualization--B.I. and I.I.; methodology--B.I. and A.A.; validation--B.I. and I.I; resources--E.B. and M.D.; data curation--I.I. and B.I.; writing--original draft preparation. B.I. and A.D.; writing--review and editing. B.I.; supervision--B.I. and A.D. All authors have read and agreed to the published version of the manuscript.  
This research received no external funding.  
Not applicable.  
The data presented in this study are available on request from corresponding author.  
The authors thank the Faculty of Pharmacy, University of Sarajevo for financial support in preparing this study.  
The authors declare no conflict of interest.