## 1 Introduction  
Bone defects in oral surgery are common and sometimes difficult to repair, requiring bone regeneration techniques to ensure the success of restorative treatment. Scientific research continues to make advances in the understanding of the biological and physiological processes involved in bone healing, regeneration and remodelling [1]. In vivo tissue engineering covers regeneration and reconstruction of tissues and organs in the body itself. The basic premise is that controlled manipulation of the extracellular microenvironmentmay lead to controlling the ability of the cells to organise themselves, grow, differentiate, and form a functioning extracellular matrix and finally new functional tissue [2]. Regenerative techniques have become routine procedures and with proven clinical results, but their predictability and wait time are still some of the drivers for continuing to investigate the development of new and improved materials for bone regeneration. Autologous bone and platelet-rich plasma are two widely used materials in the field of implantology for regenerating soft and hard tissue. However, a material that combines all the advantages of each of them separately has not yet been developed. The use of autologous bone is widely described in the literature since it is considered the gold standard for bone regeneration. Notwithstanding, despite the fact that it has excellent biological properties of osteoinduction, osteoconduction and osteogenesis, autograft presents considerable morbidity and an elevated and unpredictable resorption rate [3] but has shown that its behaviour improves on combination with other bone substitutes, obtaining a more abundant and consistent volume over time and quicker bone healing [4; 5]. Together with autologous bone, platelet-rich blood derivatives are also frequently used in tissue regeneration. Amongst these derivatives is platelet-rich fibrin [PRF]. It is a regenerative biomaterial widely used in various medical applications. Furthermore, it has gained greater popularity compared to platelet-rich plasma [PRP] because it a single-step technique to which no chemical substances need to be added. Another advantage is greater gradual release of growth factors over time [6]. A single fibrin membrane contains a large amount of growth factors and cytokines involved in bone regeneration and soft tissue maturation [7]. It is an easily manipulated biomaterial which in oral surgery is applied in periodontal therapy, alveolar preservation, surgical bone augmentation procedures and, in combination with bone grafts, in maxillary sinus elevation surgery [8; 9; 10; 11]. Its latest application, still not clinically tested, is as a decontaminant for rough titanium surfaces due to its antimicrobial properties [12; 13]. Finally, there are several publications which state that bioinorganic ions such as zinc, manganese, magnesium or silicon are essential in bone metabolism [14; 15]. Silicon is the second most abundant element in the Earth's crust and in the human body it is found mainly in areas of bone mineralisation and growth [16]. It plays a vital role in bone and connective tissue biology, and although its mechanism of action is not understood exactly, thanks to the research by [PERSON] and [PERSON] it is known that it acts by producing greater mineralisation on bone matrix through the synthesis and stabilisation of the crosslinking of collagen fibres [17; 18; 19; 20]. Silicon is an initiating factor in bone mineralisation since it is present in elevated concentrations in the osteoid matrix of immature bone and, as the bone matures, silicon concentration is diminished by the concentration of calcium [17; 21]. It has been used over the years as bone regenerative material in the form of dental implant coating as well as being incorporated in ceramic biomaterials [hydroxyapatite, tricalcium phosphate or glass ceramics] providing good results regarding bone regeneration in vitro and in vivo studies [22; 23; 24].