## 2 Methods and Materials  
### Methods--Resonant Recognition Model (RRM)  
Here, we utilized the RRM model to analyze lectins, leptin receptors, and related neuropeptides Y with the aim of finding out the common RRM frequency characterizing the control of hunger and energy balance within the organism.  
The RRM model is based on the findings that certain periodicities within the distribution of energy of delocalized electrons along protein/DNA molecules are critical for protein/DNA biological functions and/or interactions with their targets [1; 2; 3; 4; 5; 6; 7]. In the case of protein--protein receptor interactions, it has been found that phases at the characteristic interaction frequency should be opposite, i.e., should be close to \(\pi\) (3.14 rad) [1; 2; 3; 4; 5; 6; 7]. If charge transfer through these macromolecules is introduced, then charge moving through the macromolecular backbone can produce electromagnetic radiation, absorption, and resonance, with spectral characteristics corresponding to the energy distribution and charge velocity [1; 2; 3; 13; 14; 15; 16]. These wavelengths are found to correspond to electromagnetic radiation wavelengths in the range of far infra-red, infra-red, visible, and ultra-violet spectrum. The relationship between calculated RRM frequencies and corresponding electromagnetic radiation wavelengths has been empirically derived [1; 2; 3] as the following:  
\[\lambda=\text{K/f}_{\text{rrm}}\]  
where \(\lambda\) is the wavelength of light radiation in nanometers (nm), which can influence particular biological process; frm is the RRM numerical frequency; and K is the coefficient that is obtained empirically to be K = 201 [1; 2; 3; 4; 5; 6; 7].  
This concept has been further experimentally tested on electromagnetic frequencies activating l-lactate dehydrogenase [17], photon emission from dying melanoma cells [18], photon emission from lethal and non-lethal Ebola strains [19], JAK-STAT signaling pathway [20], as well as more recently on osteoblastic differentiation of stem cells by photo biomodulation [21]. Even more, the RRM model, for the first time, explains how and why external blue light can be used in treatment of Crigler-Najjar syndrome [16]. This means that, by radiating the whole body with specific RRM frequency, the desired health and medical effects can be achieved.  
Keeping all this in mind, we propose that the RRM concept is an excellent predictor for proteins and DNA-selective interactions, biological processes, and pathways in living cells. In our previous work, we calculated a large number of specific frequencies for different protein and DNA biological functions and interactions, as presented in Figure 1.  
Once the characteristic frequency for biological function of the protein is identified, it is possible to design de novo proteins with desired frequency components and subsequently with desired biological functions [1; 2; 3; 6]. The design of bioactive peptides using the RRM concept has been already successfully experimentally tested in the design of FGF analogue [1; 2; 3; 4], HIV envelope protein analogue [1; 2; 3; 22; 23; 24], IL-12 analogue [25], and peptide to mimic Myxoma virus oncolytic function [26; 27].  
When the characteristic frequency of protein-protein receptor interaction is identified, it is possible to interfere in a desired manner with this interaction, either by designing peptides using this characteristic frequency or by directly applying electromagnetic radiation of identified frequency. Such interference can achieve certain desired medical or health effects.  
The RRM concept has been already extensively published [1; 2; 3; 4; 5; 6; 7; 13; 14; 15; 16; 21] and is presented in detail within the Supplementary Material.