## 4 Discussion
\begin{table}
\begin{tabular}{c c c c c c c} \hline
**Growth Impairment** & **Feed Intake** & **Level of DI** & **Inflammation** & **Enzymes** & **Time Sampling** & **Tissues Analyzed** & **Parameters** & **Ref.** \\ \hline SRM yes & & & & & & & MSA/1 SC, ESA/1 SC, \\ SPC no & & & & & & ESA/1 PSA, GC/E, LM & [16] \\ Yes & & +++ & & 2, 7, 14 and 21 & DI & MF & [17] \\  & & ++ & \(\mathcal{F}^{\prime}\) N, Mg-ATPase, ALP, & 21 & MI and DI & [3] \\ Low SBM no & & & & & & \\ High SBM yes & No changes & +, + and +++ & ALP, LAP, malase, isomalites, lactose and sucrose & MI and DI & ME, SWV, LP levocyte & [4] \\  & & +, + and +++ & & DI & ME, SWV, LP, CT & [28] \\  & & ++ and +++ & & DI & MF, GC, LP SWV, EG, SM & [29] \\  & & ++ and +++ & & DI & MF, GC, LP SWV, EC, SM & [10] \\  & & & & & \\  & & & & & & \\  & & & & & & \\  & & & & & & \\  & & & & & & \\ Low saponins no & Low saponins no & & & & & \\ Mid-high saponins & Mid-high saponins & +, +, and +++ & Trypism activity, bile acids, brush border membrane & PI and DI & ME, LP, entrocyte vacuolization, & \\  & & & enzyme activity (LAP) & PI and DI & GC, nucleoside position within the & [20] \\ yes & yes & ++ & & DI & ME, SWV, LP, CT & [3] \\  & & +, +, and +++ & & 7, 14 and 21 & DI & Inflammation score, SM and & [18] \\ No & No changes & & & & & \\ No & No changes & & & & & \\ No & No changes & + and ++ & Brush border LAP, trypsin activity & DI & MF, SC, LP, ex, SM & [9] \\  & & + and ++ & & & & \\ SRM 17 no & & & & & & \\  & & & & & & \\  & & & & & & \\  & & & & & & \\  & & & & & & \\  & & & & & & \\ \end{tabular}
\end{table} 
Table 9: Summary of the main findings and parameters investigated of soybean meal-induced enteritis studies with Atlantic salmon (_Salimo salim_). This is not the first study where animal growth was not impaired by dietary SBM displaying equivalent performance as the fishmeal SBM-free feeds. As [PERSON] et al. [27] has demonstrated, no detrimental growth effects in feeding 20% SBM to juvenile Atlantic salmon are present; however, more aggressive inclusion levels of 40% reduced growth are evident as compared to the fishmeal control feeds. Indeed, this pattern has been described with other fish species, including California yellowtail _Seriola dorsalis_[7]. Removal of certain antinutritional factors from SBM also did not affect Atlantic salmon growth response compared to the standard SBM [9]. Conservative inclusion levels of standard SBM at the expense of fishmeal appears to be suitable as long as no intestinal health impairment is noticed. High levels of dietary SBM resulted in mild intestinal inflammation indicating enteritis progression. Speciality soybean types lacking lipoxygenenses, altered glycinin profile and oligosaccharides did not improve intestinal health of juvenile Atlantic salmon suggesting these antinutrients are not drivers of the intestinal inflammatory process in this species. No additional benefits in terms of production performance or blood biochemistry were noticed in the speciality soybean types compared to the traditional soybean. The present findings contribute to and summarize the growing literature in the antinutrient space, providing more insights to future research. Conceptualization, A.N.R., A.T.J. and C.J.S. ; Data curation, A.N.R., D.B. and T.N. ; Formal analysis, A.N.R. ; Funding acquisition, A.T.J. and C.J.S. ; Methodology, D.B. and T.N. ; Writing--original draft, A.N.R. ; Writing--review & editing, D.B., A.T.J. and C.J.S. All authors have read and agreed to the published version of the manuscript. This research was funded by Commonwealth Scientific and Industrial Research Organisation grant number SIP331. Not applicable. This research was approved by the CSIRO Queensland Animal Ethics Committee--AEC Number: 2018-44. Data Availability StatementData available upon request. The authors thank [PERSON] and [PERSON] for assistance with the histology analysis and interpretation. We also thank [PERSON], [PERSON] and our late colleague [PERSON] for the chemical analyses. The authors declare no conflict of interest.