In recent years, traditional medicine based on oral herbal preparations has attracted the attention of both consumers and healthcare professionals. However, the use of these medicinal products requires improved knowledge of their composition and stability over time in order to support or validate these therapies in humans. Liquid preparations from medicinal plants, such as tinctures and extracts from plant buds, are typical products that are widely used but still poorly understood. Plant bud extracts are defined as extracts obtained exclusively from fresh buds, shoots, young leaves, and/or roots, which are macerated and extracted with hydro-glycerol and water-alcohol mixtures [9]. Kidney extracts represent a new category of herbal products well known and widely used in gemotherapy, as well as in homeopathy and herbal medicine [10].  
The genus _Rosa_ (family _Rosaceae_) is represented on the territory of the Trans-Baikal region, Far East (Russian Federation), and Western Siberia by 3 species--_Rosa rugosa_ [PERSON], _Rosa davurica_ [PERSON], and _Rosa acicularis_ [PERSON]. (Figures 1 and 2). Fresh fruits and leaves contain up to 900 mg% ascorbic acid per dry pulp weight. Fresh petals contain 0.25-0.38% essential oil. Its neutral volatile fraction contains 86.3% phenylethyl alcohol, some inlanool, citronello, geraniol, nerol, etc. Eugenol was found in the phenolic fraction, phenylacetic, benzoic, and other acids in the acid fraction. _R. rugosa_ is a medicinal plant widely used in traditional and folk medicine. Extracts of _R. rugosa_ have been valued for Asian culinary, cosmetic, and aromatherapy purposes, and used in herbal medicines for diabetes mellitus and osteoarthritis [11]. The medicinal effects seem to be involved in the presence of many phytochemicals in _R. rugosa_ extracts, for example flavonoids, phenylpropanol, tannins, fatty acids, and terpenoids [12].  
Several studies have reported that some compounds from rose hip extracts exhibit anti-inflammatory activity in vitro. The anti-inflammatory property of the crude hydroalcoholic extract of rose hip has been proven in vivo, suggesting its potential role as one of the main therapies for the treatment of diseases associated with inflammation [13]. In Turkish folk medicine, a decoction of fresh rose hips is prepared and used to treat various stomach disorders [14]. Trans-Tiliroside (Tribuloside) has been found to be one of the main active components of aqueous acetone extracts from fruits and seeds that inhibit weight gain and lower plasma triglyceride levels in mice [15]. Additionally, clinical studies have demonstrated the positive effect of rose hip powder in the treatment of osteoarthritis [16]. Rose hip powder enhances in vitro anti-inflammatory and chondrocyte properties in leukocytes and primary chondrocytes of human peripheral blood [17]. Unfortunately, to date, there are few data providing information on the biological action of extracts of buds and leaves, and it should be noted that these preparations have never been used for preclinical and clinical trials.  
The present investigation was designed to carry out a phytochemical study involving detailed metabolomic and comparative analysis of fruits and flowers of _Rosa rugosa_ Thumb., _Rosa davurica_ Pall., and _Rosa acicularis_ [PERSON]. originating from the Trans-Baikal region, Western Siberia, and Russian Far East.