Performance can vary widely between systems, and there is still some room for improvement in thermal tumour ablation. Various studies have demonstrated improvement in the effectiveness of thermal ablation. In a modelling study, [PERSON] et al. [24] presented results dealing with the application of pulsating heat sources applied to different tissue morphologies. They concluded that the advantages were that when using a pulsating heat source instead of a constant one, high temperature peaks were avoided, and at the same time, they achieved ablation of the same tumoural area as was achieved with a non-pulsing heat source. Along this line of thought of improving the target zone, although these authors used RF, [PERSON] et al. [25] presented a study where four different types of RF waveform, i.e., half-sine, half-square, half-exponential, and damped-sine, were studied. With the use of numerical models, they concluded that their study provided information on the relationship between various RF waveforms and thermodynamic responses during the RFA process. Other researchers have used multiple antennas with various configurations for thermal ablation in their approach to improving ablation zones. In their investigation of the effects of single, double, and triple antenna configurations, [PERSON] et al. [26] used a mathematical model and concluded that the results obtained using multiple antennas offered potential for ablation zone enlargements. [PERSON] et al. [27] evaluated the thermal performance of multi-antenna arrays with the goal of treating large bone tumours. With their model, they concluded that bone tumours of more than 3 cm\({}^{3}\) could be treated using their antenna-array configuration. MW-based ablation devices are relatively recent additions to the field. [PERSON] et al. reported that it is possible to selectively heat one or more components of a material while leaving the others relatively cool [28], and that it is possible to selectively heat one phase of a multi-phase system while leaving other phases relatively cool [29; 30; 31; 32]. While these techniques were initially developed to selectively destroy the microstructure of plant and animal tissues, their application can be transposed to in situ human tissues. Hence, this selective heating characteristic of MWs could have many important applications in the medical ablation field, and it is imperative to pursue the development of methods and apparatus that can take advantage of these properties. The advantages increase significantly when the selective heating can be augmented using chemical means as opposed to physical ones, as is the case with MW and other energy-based techniques. Taken collectively, there is a pressing need to harness the selective heating characteristics of MWs to enhance the efficiency of chemical ablation procedures and broaden the range of their applicability in the medical field, with special emphasis on the area of oncology [33; 34]. In this study, a new approach combining MW ablation and chemical ablation is developed. Herein, a novel MW antenna concept, along with the use of ethanol as a susceptor, is presented, along with the preliminary results of this ablation technology, using MA-CA treatment on ex vivo bovine liver tissues.