## 3 A New Approach  
The author has pursued a new approach distinguished by its goal of building a distributed shared infrastructure rather than a single centralized repository, independent site maps or simple peer-to-peer connections. The design for the infrastructure core, called the PORTAL-DOORS System for the semantic web [1], was modeled on the enormously successful design of the IRIS-DNS System for the original web. More specifically, the Internet Registry Information Service (IRIS) registers domain names while the Domain Name System (DNS) publishes domain addresses with mapping of names to addresses for the original web. Analogously, the Problem Oriented Registry of Tags And Labels (PORTAL) registers resource labels and tags while the Domain Ontology Oriented Resource System (DOORS) publishes resource locations and descriptions with mapping of labels to locations for the semantic web. Both the IRIS-DNS System and the PORTAL-DOORS System share a common architectural style for pervasive metadata networks that operate as distributed metadata management systems with hierarchical authorities for entity registering and attribute publishing. Hierarchical control of metadata redistribution throughout the registry-directory networks constitutes an essential characteristic of this architectural style called Hierarchically Distributed Mobile Metadata (HDMM) with its focus on moving the metadata for _who what where_ as fast as possible from servers in response to requests from clients [45]. PORTAL-DOORS and IRIS-DNS each operate as information-seeking support systems that function as hierarchical registry-directory networks for the distribution of mobile metadata. While the original motivation for the design of PORTAL-DOORS has been and remains that of serving the goals of neuroinformatics for the study of gene-brain-behavior relationships, PORTAL-DOORS was also designed [1, 11] to solve several major problems of web engineering: cybersilos in scientific discourse, search engine consolidation, registry/repository centralization, the spread of misinformation, and barriers to progress in the transition from original web to semantic web (see Section 1 for further discussion). For the original internet protocols and systems including IRIS-DNS, the architectures were configured purposefully to promote failsafe redundancy and high-speed efficiency for distributed communication networks. These systems were designed with full awareness that significant risks exist when consolidation or centralization results in monopolistic control of centralized hubs as single points of failure. Moreover, non-hierarchical peer-to-peer strategies may work fine for delivery of large amounts of data to a known destination, but they will not necessarily work well for search and discovery of a small datum at an unknown destination within a large universe of data. Thus, simple flat non-hierarchical or peer-to-peer approaches that lack mobile metadata (such as the web site files of the Biositemaps initiative or the web page and data markup of the Linked Data initiative) will not scale to meet the demands presented by the ever accelerating growth in production of data, web pages, and web sites and services. Only an architecture with an HDMM style akin to the successful design of IRIS-DNS will scale sufficiently to meet the demands of the explosive growth in data requiredto solve the problems of brain diseases and other complex system challenges. This data will be available in varying kinds including public or private, raw or processed, analyzed as qualitative or quantitative results, interpreted as inferred conclusions, redacted for publication in literature, and thus, amenable to data mining, text mining, or both to varying degrees. To use a geographic metaphor, simple non-hierarchical approaches risk trapping the information seeker stuck and bogged down in the valleys of isolated lands around a world in which any information sought and found in an isolated valley is not shared with or redistributed to other isolated valleys.