# Texture-Based Analysis of \({}^{\bf 18}\)F-Labeled Amyloid PET Brain Images
## 3 Results
In [18F]FBP, the regions with the most significant features are the right frontal lobe (all except correlation, \(p\) = 0.028) and left PCC (all except correlation, \(p\) = 0.170. In the [18F]FMM study group, 5 VOIs show significant differences between A\(\beta+\) and A\(\beta-\) for all features except correlation (occipital and PCC VOIs, as well as the right temporal VOI). ROC curves of the image features using the global VOI for each study group are shown in Figure 1 and their corresponding AUC values in Table 6. The SUVR shows the best discriminatory capabilities with the highest AUC in the [18F]FMM study groups (0.96) while homogeneity performs better in the other two groups (0.813 and 0.862, respectively). Except in the case of SUVR, AUC values are higher in the study group of patients whose amyloid PET images were acquired with [18F]FBP. Lastly, only correlation results in an AUC value < 0.7. In the study group of all patients, the AUC is 0.654. When analyzing only the [18F]FMM study group, homogeneity results in an AUC value of 0.611. \begin{table}
\begin{tabular}{c c c c} \hline \hline
**Image Feature** & **All Patients** & **[18F]FBP** & **[18F]FMM** \\ \hline SUVR & **0.758** & **0.772** & **0.960** \\ Energy & **0.785** & **0.844** & **0.702** \\ Contrast & **0.203** & **0.143** & **0.269** \\ Entropy & **0.181** & **0.134** & **0.251** \\ Homogeneity & **0.813** & **0.862** & **0.749** \\ Correlation & 0.654 & 0.746 & 0.611 \\ Dissimilarity & **0.194** & **0.129** & **0.265** \\ \hline \hline \end{tabular}
\end{table} 
Table 6: Area under the curve (AUC) values from ROC analyses for the three study groups. AUCs > 0.7 and <0.3 are given in bold. \begin{table}
\begin{tabular}{c c c c c c c c c c c c} \hline \hline
**Image Feature** & **Frontal** & **Occipital** & **Parietal** & **Temporal** & **PCC** &
\begin{tabular}{c} **Anterior** \\ **Cingulate** \\ \end{tabular} \\ \hline  & **L** & **R** & **L** & **R** & **L** & **R** & **L** & **R** & **L** & **R** \\ \hline SUVR & **0.003** & **0.010** & 0.031 & 0.074 & 0.074 & **0.018** & **0.016** & **0.003** & **0.002** & **0.005** & **0.002** & 0.025 \\ Energy & 0.067 & **0.002** & **0.010** & 0.034 & 0.383 & 0.280 & 0.383 & 0.146 & **0.009** & 0.034 & 0.454 & **0.009** \\ Contrast & **0.003** & **0.001** & 0.028 & 0.051 & 0.088 & 0.056 & 0.124 & 0.406 & **0.010** & 0.022 & 0.803 & 0.618 \\ Entropy & **0.002** & **<0.001** & **0.018** & 0.025 & 0.198 & 0.170 & 0.708 & 0.589 & **0.005** & 0.025 & 0.454 & **0.006** \\ Homogeneity & **0.011** & **0.001** & **0.008** & **0.009** & 0.280 & 0.212 & 0.081 & **0.067** & **0.018** & 0.046 & 0.105 & **0.001** \\ Correlation & 0.124 & 0.028 & 0.406 & 0.618 & 0.212 & 0.198 & 0.022 & 0.056 & 0.170 & 0.360 & 0.708 & 0.212 \\ Dissimilarity & **0.004** & **0.001** & 0.025 & **0.018** & 0.124 & 0.114 & 0.124 & 0.299 & **0.016** & 0.022 & 0.967 & 0.114 \\ \hline \hline \end{tabular}
\end{table} 
Table 4: Differences between VOI image features of A\(\beta+\) and A\(\beta-\) of [18F]FBP cases evaluated by Mann–Whitney U-tests. Significant \(p\)-values after FDR correction are given in bold. (L, left; R, right; PCC, combined posterior cingulate/precuneus).