## 3 Results and Discussion  
Figure 1 and Table S1 (Supplementary Materials) reveals the results for different yeast strains used in the vinicification of five wine varieties: Pinot noir, Feetasca Neagra, Burgund Mare, Syrah, and Novac. The evaluated indicators included the following: total polyphenic content (TPC, expressed in mg GAE/L), total anthocyanins (TAs, expressed in mg equivalent Oenin/L), DPPH radical scavenging activity (% DPPH), and total antioxidant activity (TEAC, expressed in mmol equivalent Trolox/L). As it can be seen, the results varied with the yeast strain used. Thus, in the case of using the ESFC strain, the values for total polyphenic content are relatively high for all wine varieties, with the highest values for Syrah (2121.1 \(\pm\) 17.4 mg GAE/L) and Feetasca Neagra (1803.4 \(\pm\) 10.8 mg GAE/L). In the case of the total anthocyanin content, Syrah had the highest value (111.2 \(\pm\) 1.8 mg equivalent Oenin/L) and Burgund Mare the lowest one (69.1 \(\pm\) 1.2 mg equivalent Oenin/L). DPPH scavenging activity registered high values for Pinot noir (77.7%), Syrah (73.3%), and Novac (77.8%), while the total antioxidant capacity values were high for Pinot noir (7.72 mmol equivalent Trolox equivalent/L) and Novac (7.88 mmol equivalent Trolox equivalent/L). In the case of using the VS strain in the fermentation process, the TPC values are lower compared to other strains, but still quite consistent, Syrah having a high value (2027.4 \(\pm\) 12.3 mg GAE/L). The concentration of anthocyanins varied, with Syrah again showing the highest value (129.7 \(\pm\) 1.6 mg equivalent Oenin/L) and Burgund Mare the lowest (64.7 \(\pm\) 1.1). DPPH is high for Pinot noir (92.3%) and Feetasca Neagra (87.3%), and TAs for Pinot Noir (9.31) and Feetasca Neagra (8.69) show high values. The cultured yeasts obtained from the Recas area (SCR297 and SCR462) gave the wines superior qualities, so the polyphenol values were generally high, with the highest for Syrah (2201.9 \(\pm\) 15.8) and Feetasca Neagra (1822.1 \(\pm\) 11.1 mg GAE/L), and Syrah (2201.9 \(\pm\) 15.8). Figure 1: Total polyphenic content (TPC), total anthocyanins (TAs) (**a**), and antioxidant activity (DPPH and TEAC) (**b**) in wine samples obtained by using commercial and indigenous cultured yeasts. (2028.3 \(\pm\) 16.1 mg GAE/L) and Burgund Mare (1873.4 \(\pm\) 12.3 mg GAE/L), respectively. When SCR297 was used, TAs showed the highest value in Syrah wine (134.9 \(\pm\) 1.3 111.2 \(\pm\) 1.8 mg equivalent Oenin/L), and Burgund Mare showed the lowest value (56.9 \(\pm\) 1.3 111.2 \(\pm\) 1.8 mg equivalent Oenin/L). Also, when the SCR462 strain was used, respectively, TAs in Syrah wine of 108.2 \(\pm\) 1.5 were the highest and in Burgund Mare the lowest (64.5 \(\pm\) 1.2 111.2 \(\pm\) 1.8 mg equivalent Oenin/L). Instead, the scavenging activity was high for Feteasca Neagra (93.1\(\%\)) and Syrah (88.1\(\%\)) when SCR297 was applied, and in the case of the SCR462 strain it increased to 96.8\(\%\) for Pinot noir and 93.4\(\%\) for Syrah. The total antioxidant activity was high in the case of Feteasca Neagra (9.04 mmol equivalent Trolox equivalent/L) and Pinot noir wine (8.34 mmol equivalent Trolox equivalent/L) when the SCR297 strain was used. For the autochthonous strain SCR462, the values were high for Pinot noir (9.73 mmol equivalent Trolox equivalent/L) and Feteasca Neagra (8.67 mmol equivalent Trolox equivalent/L). It can be observed that yeast strains ESFC and SCR297 tended to generate high values for TPC and TAs, mainly for the Syrah and Feteasca Neagra varieties. The VS strain showed high antioxidant activities, especially for Pinot noir and Feteasca Neagra. Strain SCR462 promoted notable values for TPC and DPPH in Pinot noir and Feteasca Neagra. These observations suggest that yeast strain selection can significantly influence the phenolic composition and antioxidant activity of wines produced from different grape varieties.