## 1 Introduction
The aim of the study was to identify a correlation between the MPV value and BNP concentration, the latter being a parameter suggestive of decompensation in HF. The results from this study showed a positive correlation between the MPV value and the BNP value, and through it, demonstrated that MPV could be an indicator of HF severity and clinical status [10]. The study conducted by [PERSON] et al. [11] concluded that MPV could be a possible independent predictor of hospitalization [11]. The study was carried out in a retrospective manner on a group of 197 patients with stable chronic HF (NYHA class I-III HF) in sinus rhythm and with reduced left ventricle ejection fraction. Patients were classified into two categories according to MPV value (group I with an MPV value under 9.1 fl, and group 2 with an MPV value over 9.1 fl). The results showed that patients with an MPV value over 9.1 fl were at an increased risk of HF-related hospitalization [11]. The study conducted by [PERSON] et al. [12] found that the MPV value was much higher in patients with decompensated HF compared to those with stable HF and indicated that an increased MPV at admission could be a possible predictor of in-hospital and 6-month mortality in patients with decompensated HF [12]. The study was carried out in a prospective manner on a population of 207 patients with HF, of which 136 had decompensated HF and 71 had stable HF. Patients were followed for a period of 18 \(\pm\) 12 months. The results, based on a receiver operating characteristic analysis, revealed that MPV value on admission was a predictor for in-hospital mortality and 6-month mortality [12]. The study conducted by [PERSON] et al. [13] focused on HF patients with preserved left ventricle ejection fraction (preserved LVEF) and the prognostic impact of MPV in this population. The study was conducted in a prospective manner on 228 patients with HF and preserved LVEF and 38 control patients, who were followed over a period of 26 months. The prognostic impact of MPV was obtained using Cox hazard models. The results from this study revealed that increased MPV values were encountered in the group of patients with HF versus the control groups, and that patients with increased levels of MPV were hospitalized or died. Thus, based on the above results, the study concluded that increased levels of MPV predicted a poor prognosis in HF patients with preserved LVEF [13]. The study conducted by [PERSON] et al. [14] was an epidemiological, prospective cohort study which focused on the relationship between platelet indices (MPV and platelet-to-leukocyte ratio) and clinical outcome in HF patients. The study was carried out on 3289 participants, of which 294 were the control group, and revealed that a lower platelet-to-leukocyte ratio was associated with worsening of HF and high MPV values were associated with worse outcomes, defined by cardiac death and hospitalization due to worsening of HF [14]. The main objective of our research was to introduce new thinking to the current medical research regarding MPV as a prognostic parameter in HF. Knowing that a simple parameter such as MPV (which is found in the components of any hemogram) could provide information regarding the prognosis of patients with HF was an important consideration because through it we could potentially identify HF patients at risk of having a poor outcome, and, therefore, treat them in advance to prevent negative events.