## 1 Introduction  
Breast cancer is a predominant cancer among women [1], and over 2 million cases of breast cancer were reported worldwide in 2018 [2]. The expression of hormone receptors is a predictive feature in breast cancer treatment. Estrogen and progesterone receptor-positive breast cancers have a more favorable prognosis and are more responsive to anti-estrogen therapy than that of estrogen and progesterone receptor-negative breast cancer [3]. Ten to twenty percent of breast cancer cases are triple-negative breast cancers (TNBC). TNBC grows more aggressively, and women diagnosed with TNBC typically have a higher mortality ratio [4]. Moreover, there are very limited treatment options for TNBC, these mainly being chemotherapy and surgery, but the recurrence rate is higher compared to -hormone receptor-positive breast cancers. Limited treatment options and resistance to cytotoxic drugs are major contributing factors to the poor prognosis of TNBC [5]. Cancer cells gradually develop resistance to chemotherapy, which poses a major problem in cancer treatment. Natural products from medicinal plants and dietary sources have shown promising results in cancer treatment when used either alone or in combination with conventional chemotherapy [6]. Herbal drugs are believed to possess less side effects that arise from conventional chemotherapy [7]. It has been shown that natural compounds often exert effects by targeting multiple pathways in cancer biology, and thus are more effective than single-target chemotherapy agents [8]. The natural products either alone or in combination with conventional anticancer drugs would be an effective remedy to treat breast cancer with minimum side effects. Combining natural compounds with conventional chemotherapy can produce positive outcomes; for example, the anticancer activity of doxorubicin was improved upon by co-treatment with genistein in drug-resistant human breast cancer MCF-7/ Adr cells [9]. The supplementation of rosmary extracts with tamoxifen, trastuzumab, and paclitaxel increased the cytotoxicity and ER-\(\alpha\) and HER2 receptors downregulation in multiple drug-resistant breast cancer cells [10]. _Moricandia_ is a genus of plants of the family Brassicaceae, and many plants from this genus have been reported for their anticancer and antioxidant activities. The _Moricandia_ genus has most likely originated in the Mediterranean Basin and then spread to North Africa, the Middle East, Central Asia, and Southern Europe in arid and semi-arid environments. They usually have upright and branched stems, and the leaves are without stipules, having a featherlike shape [11]. Eight species are currently recognized in this genus, some of which have been reported to have medicinal value, or are used as traditional folk medicines. Among all, _Moricandia arrenesis_ ([PERSON]) _DC_ has been extensively studied. It is an ornamental plant that is also used in traditional cooking. The Decoctions of leaves and stem of _Moricandia arrenesis_ ([PERSON]) _DC_ are employed to treat sexually transmitted bacterial infection (syphilis) [12; 13]. The antigenotoxic and antimutagenic activities of extracts of _M. arrenesis_ and its sub-species _\"eu-arrenesis\"_, which is found in the southern region of Tunisia, have been reported [14; 15]. The in vivo analgesic, anti-inflammatory, and antipyretic properties _M. sinaica_ have been reported quite recently [16]. Keeping in view the medicinal application of the plants from this genus, extensive phytochemical screening has been done and a large number of bioactive compounds have been identified from medicinally important plants of this genus. The methanol extract of _M. arrenesis_ contains a high amount of Quercetin and kaempfer [17]. The positive impact of quercetin and kaempfer on type 2 diabetes mellitus has been shown in experimental animal models [18; 19]. Various sulfur compounds, glucosinolates and isothicyanates, and indole glucosinolates polyphenols have been reported from _Moricandia arrenesis_[20; 21; 22; 23], Quercetin, and kaempfer from _M.