## 1 Introduction  
Cancer is an uncontrollable division and growth of cells in the body that is believed to be the leading cause of mortality worldwide [1]. Lung cancer is one of the predominantly diagnosed cancer types common among patients. The alteration in genetic level due to recent changes in the environment and trends in lifestyle accounts for the increased number of cancer cases [2]. Lung cancer is further classified into Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC) [3]. NSCLC is a heterogenous type of cancer, with 85 to 90% of the cases commonly associated with primary and secondary smokers; workers exposed to asbestos, nickel, chromium, arsenic, and beryllium; people with a family history of lung cancer; people who live in a region with high air pollution. The class NSCLC has reduced sensitivity to radiation and chemotherapy [4]. The epithelial cells covering the central bronchi to alveoli at the terminal of the lung are the site of origin for the NSCLC [5]. NSCLC includes multiple types of cancer, viz., adenocarcinoma (LUADs), large cell cancers, and squamous cell cancers (LUSCs). LUSCs arise usually near the central bronchus and LUADs usually initiate from the periphery of lung tissue [6]. Lung carcinogenesis follows a complex multiple-step pathway to develop into a diseased condition. LUSCs and LUADs develop from a defined-premalignant lesion [7]. Gradually, the precursor lesions turn invasive and undergo morphological changes due to dysplasia, metaplasia, hyperplasia, and carcinoma [8]. Symptoms such as chest pain, weight loss, worsening cough, hoarseness, hemoptysis, and dyspnea are found to be associated with patients suffering from lung cancer [9]. Plants have been an unconditional support system for food, feed, and medicine since ancient civilizations. Plants have been profoundly used as a therapeutic source to heal a wide array of diseases in humans [10]. Following up on this knowledge, a high-fold interest is growing among researchers to unveil and study the chemical attributes of various compounds present in plants. Many novel phytochemicals having anticancer potentials have been identified from the various plant families. Alliaceae is one among them, having therapeutic potential against many human ailments. This family consists of approximately 700 members, distributed across Asia, Europe, North America, and Northern Africa [11]. The representatives vary in color, odor, taste, and phenotypic traits, while showing affinities in terms of phytochemical, nutraceutical, and biochemical value. _Allium tuberosum_ Rottler [PERSON] is one of the significant therapeutic representatives of the family. Consumption and cultivation of _Allium tuberosum_ are mainly reported from China (origin), Southern Asia, and in the Northeastern region of India [12; 13; 14]. This plant species is reported to have antidiabetic, hepatoprotective [15], cytotoxic, and antitumor activity [16]. Because the crude extract of this plant demonstrated antitumor and cytotoxic properties, we chose it for the identification of possible anti-NSCLC phytoocompounds. Taking a clue from the literature and the retrieval of data from KEGG pathways, four different targets for the progression of NSCLCs, viz., B-Raf, EGFR, K-Ras, and PI3K, were selected for in silico-based anticancer activity prediction [17]. The genome studies of most lung cancer patients reflect highly the presence of a mutation in the BRAF (a proto-oncogene that encodes B-Raf and belongs to the Raf kinase family) [18]. The BRAF mutation leads to the activation of the MAP kinase pathway and suppresses phosphorylation of the AKT-induced pathway inhibition, resulting in tumorigenesis [19]. EGFR (Epidermal Growth Factor Receptor) has become another significant target for the therapeutic process to check NSCLCs complications [20]. Somatic mutation of the EGFR gene was found commonly in populations of Japanese and U.S lung cancer patients [21]. Further, KRAS is a mutated oncogene common in NSCLC cases [22].