## 1 Introduction
Gene abbreviations in **(a)**: _ARO1_: _3-phosphhikhimate 1-carboxyvinyltransferase, ARO2_: _chorisinite synthase_, ARO3_: _3-deoxy-7-phosphhiophantine synthase 3, ARO4_: _3-deoxy-7-phosphhiophantine synthase 4, ARO7_: _chorisinite mutase_, ARO8_: _aromatic amino acid aminotransferase_, HIS1_: _ATP phosphoribosyltransferase_, HIS2_: _histidinolphosphatase_, HIS4_: _phosphhiogly-ATP pyrophosphhydrolase_, HIS5_: _histidinol-phosphate aminotransferase_, HIS6_: _phosphhioglyforminino-5-aminoimidazole carboxamide riboide isomerase_, HIS7_: _imidazole glycerol phosphate synthase_, NQM1_: _transaldolase_, PHA2_: _prephenate dehydratase_, PRS1_: _ribose 5-phosphate isomerase_, PRS2_: _ribose-phosphate pyrophosphhiokinase 2, PRS3_: _ribose-phosphate pyrophosphate3 3, PRS4_: _ribose-phosphate pyrophosphate3 4, PRS5_: _ribose-phosphate pyrophosphate3 5, RK1_: _ribose 5-phosphate isomerase_, RPE1_: _ribulose-phosphate 3-epimerase_, TAL1_: _transaldolase_, TKL1_: _transkeldolase 1, TKL2_: _transkeldase 2, TRP2_: _anthranilate synthase_, TRP3_: _anthranilate synthase_/_indole-3-glycerol-phosphate synthase_, TRP4_: _anthranilate phosphoribosyltransferase_, TRP5_: _ tryptophan synthase_, TYR1_: _prephenate dehydrogenase_. In **(b)**: _BAT1_: _branched-chain amino acid aminotransferase_ 1, BAT2_: _branched-chain amino acid aminotransferase_ 2, CHA1_: _\(\mathsf{l}\)-serine_/_\(\mathsf{l}\)-threonine ammonia- lyase_, CYS4_: _cysteine synthase_, GLY1_: _threonine alidase_, ILY1_: _\(\mathsf{l}\)-serine_/_\(\mathsf{l}\)-threonine ammonia-lysine_, ILY2_: _acelocalate synthase_ catalytic subunit 2, ILV3_: _dihydroxy-acid dehydratase_, ILV5_: _ketol-acid reductoisomerase_, ILV6_: _acelocalate synthase_, IRC7_: _cysteine-S-conjugate beta-lyase_, LEUI: 3-isopropylmalate dehydratase_, LEUI4_: _2-isopropylmalate synthase 4, LEUI9_: _2-isopropylmalate synthase 9, MET2_: _homoserine O-acetyltransferase_, MET6_: 5-methyltetrahydropropertytrigluamate-homocysteine methyltransferase_, SAM1_: \(\mathsf{s}\)-adenosylmethionine synthetase1_, SAM2_: \(\mathsf{s}\)-adenosylmethionine synthetase2_, SER1_: _phosphoserine aminotransferase_, SER2_: _phosphhiatase_, SER3_: _D-3-phosphoglycerate dehydrogenase 3, SER3_: _D-3-phosphoglycerate dehydrogenase 33, SHM1_: _glycine hydroxymethtransferase1_, SHM2_: _glycine hydroxymethlltransferase2_, STR2_: _cystathione gamma-synthase_, STR3_: _cysteine-S-conjugate beta-lyase_, THR1_: _homoserine kinase_, THR4_: _threonine synthase_. In **(c)**: _AAT1_: _alanine transaminase_, _AAT1_: _aspartate aminotransferase_, _AAT2_: _alanine transaminase_, _AAT2_: _aspartate aminotransferase_, ACO2_: _homocatinse_, ALT1_: _alanine transaminase 1, ALT2_: _alanine transaminase 2, ARG1_: _agrininosuccinate synthase_, _ARG2_: _amino-acid N-acetyltransferase_, ARG3_: _or-nithinic carbamohydtransferase_, ARG4_: _agrininosuccinate lyase_, ARG7_: _amino-acid N-acetyltransferase_, ARG8_: _glutamate N-acetyltransferase_, ARG56_: _N-acetyl-gamma-glutamyl-phosphate reductase_, _ASN1_: _asparagine synthase 1, ASN2_: _asparagine synthase 2, CAR1_: _arginase_, GLT1_: _glutamate synthase_, GLN1_: _glutamine synthetase_, HOM2_: _aspartate-semialdehyde dehydrogenase_, HOM3_: _aspartate kinase_, HOM6_: _homoserine dehydrogenase_, LYS1_: _sacchropine dehydrogenase 1, LYS2_: _\(\mathsf{l}\)-2-aminoadipate reductase_, LYS4_: _homocatinte hydratase_, LYS9_: _sacchropine dehydrogenase 9, LYS12_: _homoisocitrate dehydrogenase_, LYS20_: _homocitrate synthase 20, LYS21_: _homocitrate synthase 21, PRO1_: _glutamate 5-kinase_, PRO2_: _glutamate-5-semialdehyde dehydrogenase_, PRO3_: _pyruvate-5-carboxylate reductase_. The similarly colored and shaped marks in figures mean transcription levels of the same enzyme genes. **(a)** Comparison of gene transcription levels in YG+HLMU medium and WG+HLMU medium for biosynthesis of amino acids relating to pentose phosphate pathway. **(b)** Comparison of gene transcription levels in YG+HLMU medium for biosynthesis of amino acids from pyruvate.