###### Abstract
The application of nitrogen plasma for BC modification has been found to improve the adhesion of eukaryotic cells to the BC surface and increase its porosity [10; 11]. The modification of BC membranes' surfaces using oxygen plasma can lead to a decrease in the effective pore area and water flux, while increasing the number of O-H groups. As a result, there is a significant change in the water contact angle, making the membrane surface more hydrophilic [12]. The modification of BC with argon plasma can confer bactericidal properties, making it suitable for use as antibacterial and antiviral filters based on BC [11]. Moreover, the introduction of new functional groups on the surfaces of polymer matrices through plasma exposure may affect the release process of active compounds, including enzymes, from the surfaces of polymeric materials, especially in applications related to biofilm eradication [13; 14; 15; 16]. _Pseudomonas aeruginosa_ and _Staphylococcus aureus_ are the most frequently isolated bacterial pathogens found in wounds of various origins. Unlike wounds infected by _S. aureus_, which can readily colonize the upper layers of the wound, _P. aeruginosa_ tends to establish itself in the deeper regions of the wound bed, making eradication more challenging. _P. aeruginosa_ is known for its high resistance to antimicrobial agents, resulting in a significant prolongation of the wound healing process or even complete stoppage of healing [17; 18]. The main reason for the increased risk associated with _P. aeruginosa_ infections is its ability to form biofilms, which are recognized as the most significant virulence factors of this bacterium. Biofilms exhibit a complex structure composed primarily of proteins, nucleic acids, lipids, biosurfactants, and exopolysaccharideacharides. The presence of exopolysaccharideacharides plays a crucial role due to their diverse functions, including bacterial adhesion to surfaces, protection against phagocytosis and the immune system, and restriction of antibiotic diffusion within the biofilm structure. _P. aeruginosa_ is capable of synthesizing three of the polysaccharides involved in biofilm matrix formation: alginate, Pel, and Psl. However, the specific types and quantities of the polysaccharides produced can vary depending on the strain [19; 20; 21; 22; 23]. Psl is a neutral polysaccharide composed of repeating units of D--mannose, D--glucose, and D--rhannose, while until recently, the exact structure of Pel remained unclear. In the latest research, [PERSON] et al. described the structure of Pel as a linear homopolymer of partially de-N-acetylated \(\alpha\)-1,4-GalNAc comprised predominantly of dimeric repeats of galactosamine and N--acetylgalactosamine [24; 25]. To prevent the development of these polysaccharide components of the biofilm matrix, it is possible to use an enzyme with specific activity against the _P. aeruginosa_ matrix, such as PelA\({}_{\rm h}\) and PslG\({}_{\rm h}\) glycoside hydrolases [26; 27; 28; 29; 30]. In the field of medicine, it is crucial to develop suitable approaches for creating non-fouling biomaterials. Currently, there is a growing interest in the use of immobilized PelA\({}_{\rm h}\) and PslG\({}_{\rm h}\) on polymer surfaces in medical applications. These proteins have shown potential in limiting the development of _P. aeruginosa_ biofilms, thereby aiding the effectiveness of antibiotics and the immune system. [PERSON] et al. investigated the immobilization of PslG\({}_{\rm h}\) on surfaces such as silica glass, polydimethylsiloxane, polystyrene, and indwelling catheters, confirming the ability of surface-attached enzymes to effectively inhibit _P. aeruginosa_ biofilm formation. Similarly, [PERSON] et al. conducted studies demonstrating that the adsorption of PelA\({}_{\rm h}\) on BC surfaces could reduce the polysaccharide components of the _P. aeruginosa_ matrix, thereby expanding the utility of BC as a wound-dressing material [26; 27; 30; 31].