## 3 Limitations of BSA Dosing
\begin{table}
\begin{tabular}{c c c} \hline
**Authors (Year)** & **Formula** & **Estimated BSA Values (m\({}^{2}\))** \\ \hline [PERSON] (1879) [27] & \(0.1053\times W^{2/3}\) & 2.24 \\ \hline DuBois and DuBois (1916) [24] & \(0.007184\times W^{0.425}\times H^{0.725}\) & 2.04 \\ \hline Faber and Melcher (1921) [28] & \(0.00785\times W^{0.425}\times H^{0.725}\) & 2.23 \\ \hline [PERSON] (1925) [29] & \(0.007246\times W^{0.425}\times H^{0.725}\) & 2.06 \\ \hline [PERSON] (1932) [30] & \(0.0087\times(W+H)-0.26\) & 2.03 \\ \hline [PERSON] (1935) [31] & \(\begin{array}{c}0.0003207\\ \times(W\times 1000)^{0.7285-0.0188\times\log_{10}}\left(W\times 1000\right) \times H^{0.3}\end{array}\) & 2.18 \\ \hline [PERSON] (1937) [32] & \(0.0128\times W+0.0061\times H-0.1529\) & 2.10 \\ \hline [PERSON] and [PERSON] (1954) [33] & \(0.0097\times(W+H)-0.545\) & 2.00 \\ \hline [PERSON] and [PERSON] (1955) [34] & \(0.007466\times W^{0.425}\times H^{0.725}\) & 2.12 \\ \hline [PERSON] (1956) [35] & \begin{tabular}{c} Men : \(0.005902\times W^{0.407}\times H^{0.7276}\) \\ Women : \(0.008692\times W^{0.442}\times H^{0.678}\) \\ \end{tabular} & 2.00 \\ \hline [PERSON] (1958) [36] & \(0.01131\times W^{0.4092}\times H^{0.6468}\) & 2.00 \\ \hline [PERSON] and [PERSON] (1961) [37] & \(0.007\times W^{0.425}\times H^{0.725}\) & 1.99 \\ \hline [PERSON] et al. (1968) [38] & \(0.008883\times W^{0.444}\times H^{0.663}\) & 2.01 \\ \hline [PERSON] and [PERSON] (1970) [39] & \(0.0235\times W^{0.51456}\times H^{0.42246}\) & 2.15 \\ \hline [PERSON] et al. (1978) [40] & \(0.024265\times W^{0.5378}\times H^{0.3964}\) & 2.16 \\ \hline [PERSON] (1987) [41] & \(\sqrt{W\times H/3600}\) & 2.12 \\ \hline [PERSON] (1989) [42] & \((W+H-60)/100\) & 2.03 \\ \hline [PERSON] (1989) [43] & \(0.001315\times W^{0.262}\times H^{1.2139}\) & 2.15 \\ \hline [PERSON] and [PERSON] (2000) [44] & \(0.00949\times W^{0.441}\times H^{0.655}\) & 2.03 \\ \hline [PERSON] and [PERSON] (2001) [45] & \(0.1173\times W^{0.6466}\) & 2.27 \\ \hline [PERSON] et al. (2001) [46] & \begin{tabular}{c} Men : \(0.01281\times W^{0.44}\times H^{0.6}\) \\ Women : \(0.01474\times W^{0.47}\times H^{0.55}\) \\ \end{tabular} & 2.06 \\ \hline [PERSON] and [PERSON] (2003) [47] & \(0.02036\times W^{0.427}\times H^{0.516}\) & 2.01 \\ \hline [PERSON], [PERSON], [PERSON] (2003) [48] & \(0.015925\times(W\times H)^{0.5}\) & 2.02 \\ \hline [PERSON] et al. (2010) [49] & \
\begin{tabular}{c} Men : \(0.000579479\times W^{0.38}\times H^{1.24}\) \\ Women : \(0.000975482\times W^{0.46}\times H^{1.08}\) \\ \end{tabular} & 1.86 \\ \hline [PERSON], [PERSON], [PERSON] (2010) [50] & \(0.00713989\times W^{0.404}\times H^{0.7437}\) & 2.03 \\ \hline [PERSON] et al. (2017) [51] &
\begin{tabular}{c} General : \(0.0151\times H^{0.5751}\times W^{0.4259}\) \\ Sub - group : \(0.0151\times H^{0.8516}\times H^{0.3262}\times\) \\ \(exp(-0.0120\times Sex)\times exp(0.0036\times BMI)\) \\ \end{tabular} & 2.00 \\ \hline \end{tabular}
\end{table} 
Table 1: Previously developed body surface area (BSA) estimation formulae and estimated BSA values for a typical male patient. weight (_BMI_) and BSA--do not account for. Measures of overall body mass and size assume both homogenous body composition and drug distribution throughout the body. However, using these measures in isolation, especially in atypical populations, should be performed with caution since it is now widely acknowledged that they are unable to distinguish between fat and lean tissue, or provide information regarding the distribution of mass around the body [52]. The combination of these factors can reduce the confidence of practitioners when determining individualised chemotherapy dosages for people of atypical body types, particularly as they try to limit the risk of over-dosing and consequent excess toxicity, or under-dosing, leaving patients at risk of reduced anti-cancer effects from their treatment.