## Result
### Docking Scores and Inhibition of Receptors  
In the four selected targets, some of the identified compounds show the best binding efficacy than the positive controls of these respective targets. In EGFR triple mutant protein, ethyl2E,4Z-hexadecationoate shows the best binding efficacy with a MolDock  
Figure 4: **(A)** Chromatogram of GC-MS of AT—MeOH; **(B)** chromatogram of HRLC-MS of AT—MeOH in +ve ESI; **(C)** chromatogram of HRLC-MS of AT—MeOH in \(-\)ve ESI. score of \(-124.85\), whereas positive control gefitinib shows \(-103.14\). Other than ethyl2E,_AZ_-hexadecadienoate, 19 more phytocompounds from this plant show better binding than its positive control (Table 3). The docking result with B-Raf V600E mutant protein reveals that the compound americine shows the best binding followed by 9-Hydroxy-9,11,15-octadecatrienoic acid compared to its positive control Dabrafenib (MolDock Score \(-138.89\)). Americine shows the binding score, i.e., MolDock score \(-144.45\). These two proteins are involved in cancer cell proliferation. The binding minimizes the cancer cell proliferation and formation of the malignant tumor. Two more selected proteins involved in the antiapoptotic activity of carcinoma are also inhibited by the identified compounds of the selected plant. G12C mutant K-Ras protein is inhibited by 8-hydroxyoctadeca-9,12-dienoic acid (MolDock Score \(-140.70\)) along with more than 13 compounds, whereas the binding efficiency shown by its positive control Adagrasib is \(-136.77\). Di-n-octyl phthalate (MolDock score \(-133.50\)) shows the best binding efficacy with the target protein PI3K than its positive control Duvelisisib (MolDock score \(-113.52\)). In addition, eight more compounds show better binding efficiency than the positive control of PI3K. \begin{table}
\begin{tabular}{l c c c c} \hline \hline \multicolumn{1}{c}{\multirow{2}{*}{**Compound Name**}} & \multicolumn{5}{c}{**Docking Score (MolDock Score)**} \\ \cline{2-5}  & **EGFR** & **K-Ras** & **PI3K** & **B-Raf** \\ \hline Gefitinib (Positive Control of EGFR) & \(-103.14\) & - & - & - \\ Adagrasib (Positive Control of K-Ras) & - & \(-136.77\) & - & - \\ Duvelisib (Positive Control of PI3K) & - & - & \(-113.52\) & - \\ \hline Dabrafenib (Positive Control of B-Raf) & - & - & - & \(-138.89\) \\ \hline Americine & \(-112.82\) & \(-139.02\) & \(-115.76\) & \(\mathbf{-144.45^{*}}\) \\ \hline
9-Hydroxy-9,11,15-octadecatrienoic acid (9-HOTE) & \(-121.96\) & \(-144.61\) & \(-123.48\) & \(-140.27\) \\ \hline Di-n-octyl phthalate & \(-110.60\) & \(-154.00\) & \(\mathbf{-133.50^{*}}\) \\ \hline
8-hydroxyoctadeca-9,12-dienoic acid (8S-HODE) & \(-111.91\) & \(\mathbf{-140.70^{*}}\) & \(-127.40\) \\ \hline
9-hydroxyoctadeca-10,12,15-trienoic acid [9(S)-HpOTrE] & \(-123.38\) & \(-142.13\) & \(-126.70\) \\ \hline \(\alpha\)-Linolenic Acid & \(-118.29\) & \(-142.05\) & \(-122.03\) \\ \hline Fumaricaciddi(2-decy)ester & \(-117.66\) & \(-167.84\) & \(-127.15\) \\ \hline
3-ketosteearic acid & \(-115.01\) & \(-143.54\) & \(-123.17\) \\ \hline
1,2-Benzenedicarboxylatelicacidbutyloclylester & \(-103.81\) & Low Score & \(-114.19\) \\ \hline N,N\({}^{\prime}\)-Pentamethylenebis[s-3-aminopropyl thiosulfuric acid & \(-110.92\) & \(-150.51\) \\ \hline Ethyl2E,_AZ_-hexadecadienoate & \(\mathbf{-124.85^{*}}\) & \(-144.21\) \\ \hline
9,12-Octadecadien-1-Ol & \(-110.65\) & \(-142.31\) \\ \hline Eicosanoicacid, Methyl ester & \(-106.81\) & \(-141.91\) \\ \hline Petroselinicacid & \(-115.01\) & \(-138.96\) \\ \hline
10,16-dihydroxy-palmitic acid & \(-120.06\) & \(-137.31\) \\ \hline Nonadecane,9-methyl & \(-114.58\) \\ \hline Methaphenilene & \(-109.04\) \\ \hline
10,11-Epoxy-3,7,11-trimethyl-2E,6E-tridecadienoic acid & \(-105.83\) \\ \hline Glycerol1,2-diacetate & \(-105.46\) \\ \hline Leucyl-glutamate & \(-104.83\) \\ \hline \hline \end{tabular}  
* best binding shown among all compounds and positive control for this target.  
\end{table} 
Table 3: Docking score ligands against the targets in comparison with the positive control, i.e., market-approved drugs against the target.