## 2 Materials and Methods
### Fourier Transform Infrared Measurements
Subsequently, the solvent was removed under vacuum, and the residue was purified by flash chromatography using hexane and ethyl acetate (\(v/v\) = 6:1) as the eluent to obtain the title compounds. _3-(Benzylideneamino)-6-chloro-1-(3,3-dimethylbutanoyl)-2-phenyl-2,3-dilydroquinazolin-4(1H)-one_ (**3a**): white solid, yield 49.5%; m.p. 149.5-150.8 \({}^{\circ}\)C; \({}^{1}\)H-NMR (600 MHz, DMSO-\(d_{6}\)) \(\delta\) 9.17 (s, 1H), 7.81 (m, 4H), 7.61 (s, 2H), 7.52-7.41 (m, 3H), 7.33-7.13 (m, 5H), 2.67 (s, 2H), 0.95 (s, 9H); \({}^{13}\)C-NMR (151 MHz, DMSO-\(d_{6}\)) \(\delta\) 171.56, 158.59, 152.50, 136.82, 136.54, 134.42, 133.39, 131.45, 130.95, 129.34, 129.27, 129.02, 128.16, 128.01, 127.57, 126.33, 125.90, 44.73, 32.14, 29.86; HRMS: \(m/z\) Calcd. for C\({}_{27}\)H\({}_{26}\)ClN\({}_{3}\)O\({}_{2}\) [M + H]\({}^{+}\) 460.1786, found 460.1776. _6-Chloro-1-(3,3-dimethylbutanoyl)-3-((4-methylbenzylidene)amino)-2-(-tolyl)-2,3-dilydroquinazolin-4(1H) -one_ (**3b**): white solid, yield 53.3%; m.p. 149.3-150.1 \({}^{\circ}\)C; \({}^{1}\)H-NMR (600 MHz, DMSO-\(d_{6}\)) \(\delta\) 9.07 (s, 1H), 7.80 (s, 1H), 7.77-7.63 (m, 3H), 7.59 (s, 2H), 7.30-7.22 (m, 2H), 7.12-7.00 (m, 4H), 2.65 (s, 2H), 2.33 (s, 3H), 2.17 (s, 3H), 0.94 (s, 9H); \({}^{13}\)C-NMR (151 MHz, DMSO-\(d_{6}\)) \(\delta\) 171.48, 158.50, 152.61, 141.45, 138.43, 136.80, 133.53, 133.29, 131.69, 130.89, 129.94, 129.81, 128.16, 127.97, 127.51, 126.26, 125.99, 44.75, 32.13, 29.86, 21.56, 20.97; IR (\(v\), cm\({}^{-1}\)): 3430.9, 2954.1, 1678.4, 1665.8, 1604.4, 1466.7, 1360.8, 1229.5, 1140.3, 824.2, 754.5, 688.0, 592.2; HRMS: \(m/z\) Calcd. for C\({}_{29}\)H\({}_{30}\)ClN\({}_{3}\)O\({}_{2}\) [M + H]\({}^{+}\) 488.2027, found 488.2050. _6-Chloro-1-(3,3-dimethylbutanoyl)-3-((4-methoxyphenylylene)amino)-2-(4-methoxyphenyl)-2,3-dilydroquinazolin -4(1H)-one_ (**3c**): white solid, yield 59.5%; m.p. 104.5-105.8 \({}^{\circ}\)C; \({}^{1}\)H-NMR (600 MHz, DMSO-\(d_{6}\)) \(\delta\) 9.04 (s, 1H), 7.80 (s, 1H), 7.76-7.72 (m, 2H), 7.65-7.57 (m, 3H), 7.08-7.01 (m, 4H), 6.84-6.82 (m, 2H), 3.80 (s, 3H), 3.64 (s, 3H), 2.66 (s, 2H), 0.95 (s, 9H); \({}^{13}\)C-NMR (151 MHz, DMSO-\(d_{6}\)) \(\delta\) 171.47, 162.05, 159.69, 158.34, 136.74, 133.19, 130.83, 129.93, 128.27, 127.95, 127.67, 127.45, 126.83, 126.04, 114.85, 114.60, 55.83, 55.50, 44.80, 32.15, 29.87; IR (\(v\), cm\({}^{-1}\)): 3430.4, 2957.9, 2226.2, 1695.2, 1669.1, 1479.8, 1422.5, 1364.4, 1262.8, 1233.3, 1147.7, 837.9, 557.1; HRMS: \(m/z\) Calcd. for C\({}_{29}\)H\({}_{30}\)ClN\({}_{3}\)O\({}_{3}\) [M + H]\({}^{+}\) 626.2707, found 626.2737. _6-Chloro-1-(3,3-dimethylbutanoyl)-3-((4-cyanophenylidene)amino)-2-(4-cyanophenyl)-2,3-dilydroquinazolium-4(1H)-one_ (**3d**): white solid, yield 46.7%; m.p. 115.3-116.1 \({}^{\circ}\)C; \({}^{1}\)H-NMR (600 MHz, DMSO-\(d_{6}\)) \(\delta\) 9.27 (s, 1H), 7.99-7.97 (m, 2H), 7.96-7.84 (m, 3H), 7.83-7.74 (m, 3H), 7.66 (s, 2H), 7.38-7.36 (m, 2H), 2.68 (s, 2H), 0.94 (s, 9H); \({}^{13}\)C-NMR (151 MHz, DMSO-\(d_{6}\)) \(\delta\) 171.66, 158.56, 141.83, 138.84, 136.71, 133.91, 133.31, 133.28, 131.31, 128.70, 128.11, 127.82, 127.51, 125.42, 118.99, 118.58, 113.25, 112.10, 44.67, 32.09, 29.82; IR (\(v\), cm\({}^{-1}\)): 3677.4, 2964.2, 1670.3, 1481.0, 1356.5, 1270.9, 1231.8, 1143.7, 1087.3, 826.0, 692.8, 518.2; HRMS: \(m/z\) Calcd. for C\({}_{29}\)H\({}_{24}\)ClN\({}_{5}\)O\({}_{2}\) [M + H]\({}^{+}\) 510.1619, found 510.1643. _6-Chloro-1-(3,3-dimethylbutanoyl)-3-((4-trifluoromethyl)benzylidene)amino)-2-(4-(trifluoromethyl)phenyl) -2,3-dilydroquinazolium-2,3-dilydroquinazolium-4(1H)-one_ (**3e**): white solid, yield 53.5%; m.p.