## 1 Introduction  
Gas hydrates are stable inclusion compounds made up of a network of water molecule cages that act as a host that trap light hydrocarbon as guest statistical analysis on experimental Hydrate Liquid-Vapor Equilibrium (HLVE) data under high pressure and low-temperature conditions during deep-water energy exploration and recovery [1; 2; 3; 4; 5; 6; 7]. The risk of gas hydrate formation is highly prevalent and poses a significant operational and safety challenge [8; 9]. When the pipeline is clogged with gas hydrates, the explosion of pipes can occur, which will pose a threat to safety and environment and lead to economic loss [10; 11; 12; 13]. Although many methods are handled to prevent hydrate formation, the chemical inhibition method is the most prevalent [14]. The conventional way of preventing gas hydrate formation is to -inject Thermodynamic Hydrate Inhibitors (THIs) into pipelines, thereby shifting hydrate formation conditions to higher pressure and lower temperature regions [15; 16; 17; 18; 19]. However, there are a few drawbacks associated with the conventional gas hydrates inhibitor, especially on the volatility of the chemical. Thus, researchers have been working towards Ionic Liquids (ILs) as gas hydrate inhibitors but currently looking for an alternative as the ILs itself have their disadvantages [1; 4; 6; 15; 17; 18; 20; 21; 22]. ILs need a high purity, are expensive, require a large number of salts and solvents for complete exchange of anions, and have poor biodegradability. These drawbacks can be overcome with the use of Deep Eutectic Solvent (DES), which is known for its cheap, non-toxic, and biodegradable nature. DES is an analog of ILs, which possesses a few similar characteristics of an ionic liquid. DES is usually in liquid form and is usually formed by mixing a quaternary ammonium salt with hydrogen bond donors [23]. Generally, a eutectic system is a mixture of components having the lowest melting point through virtue of specific proportions. Without covalent or ionic bonds, these components interact merely through intermolecular forces [24]. Detailed works comparing DES and ILs have been done, and DESs have been slowly replacing ILs in various fields [23; 24; 25; 26; 27; 28; 29; 30; 31; 32; 33]. DESs have great potential to be effective and eco-friendly Thermodynamic Hydrate Inhibitors (THIs) because DESs have functional groups capable of forming hydrogen bonds with water. DESs also have high biodegradability and low toxicity, besides exhibiting negligible vapor pressure [34; 35; 36]. DES is known for its cheap, non-toxic, and biodegradable characteristic, which is also characterized by a significant depression of low melting point. Four types of DESs can be formed, namely, (1) quaternary ammonium salt + metal chloride, (2) quaternary ammonium salt + metal chloride hydrate, (3) quaternary ammonium salt + hydrogen bond donor, and (4) metal chloride hydrate + hydrogen bond donor [25; 31]. Nature showed by Choline Chloride, Propagatioic Acid, 3-Phenyl Propionic Acid, Itaconic Acid, and 3-Mercaptopropionic Acid-based DESs, as potential shale inhibitors in water-based drilling fluids, is further evidence of the DESs to be efficient THIs [37]. In the research work by [PERSON] et al. [38], DESs based on Choline Chloride displayed significant absorption of H\({}_{2}\)O from natural gas down to the concentrations specified for pipelines to avoid hydrate formation. As DESs are generally formed by mixing Hydrogen Bond Acceptors (HBA) and Hydrogen Bond Donors (HBD), there is a significant margin to be exploited in making the greener gas hydrate inhibitors. Many substances have been tested to be potential gas hydrate inhibitors but have displayed either biodegradability or performance issues.