## 3 Proposed IBFO-KELM Model
**Acknowledgments: This research is funded by the National Natural Science Foundation of China (61602206, 61702376), Zhejiang Provincial Natural Science Foundation of China (LY17F020012, LY18F020022), Science and Technology Plan Project of Wenzhou of China (ZG2017019). **Author Contributions: [PERSON] and [PERSON] conceived and designed the experiments; [PERSON] performed the experiments; [PERSON] and [PERSON] analyzed the data; [PERSON] contributed reagents/materials/analysis tools; [PERSON] wrote the paper. **Conflicts of Interest: The authors declare no conflict of interest. **

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\begin{tabular}{c c c c c} \hline \hline \multirow{2}{*}{**Method**} & \multicolumn{4}{c}{**Metrics**} \\ \cline{2-5}  & **ACC** & **MCC** & **Sensitivity** & **Specificity** \\ \hline NB & 0.9182 \(\pm\) 0.0543 & 0.7766 \(\pm\) 0.1495 & 0.9800 \(\pm\) 0.0322 & 0.7350 \(\pm\) 0.1634 \\ SVM & 0.8971 \(\pm\) 0.0735 & 0.7122 \(\pm\) 0.2148 & 0.9595 \(\pm\) 0.0469 & 0.7100 \(\pm\) 0.2601 \\ RF & 0.9382 \(\pm\) 0.0405 & 0.8337 \(\pm\) 0.1133 & 0.9652 \(\pm\) 0.0367 & 0.8500 \(\pm\) 0.1414 \\ \hline \hline \end{tabular}
\end{table} 
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