###### Abstract  
Increasing evidence sustains the potential of periodontitis as a risk factor for chronic kidney disease (CKD). Our study aimed to analyze several periodontal specific inflammatory biomarkers within the gingival crevicular fluid (GCT) of patients with CKD, compared to patients with normal kidney function, providing an inflammatory profile of the dialysis patient. The study comprised 79 patients divided into: group 1 (59 subjects with periodontitis and CKD) and group 2 (20 patients with periodontitis, without other systemic conditions). Clinical diagnosis was performed via dental and periodontal examination. GCF samples were collected from each patient, and the levels of TNF-\(\alpha\), IL-1\(\beta\) and MMP-8 were determined by using ELISA assay. In group 1, the average values were: 22.85 \(\pm\) 5.87 pg/mL for TNF-\(\alpha\), 33.00 \(\pm\) 39.68 pg/mL for IL-1\(\beta\) and 18.80 \(\pm\) 27.75 pg/mL for MMP-8. In group 2, the mean values were: 2.10 \(\pm\) 1.34 pg/mL for TNF-\(\alpha\), 0.71 \(\pm\) 2.42 pg/mL for IL-1\(\beta\) and 5.35 \(\pm\) 0.37 ng/mL for MMP-8. Statistical analysis revealed significant differences between groups as referring to all three biomarkers and, TNF-\(\alpha\) and MMP-8, in certain stages of periodontitis. The level of TNF-\(\alpha\), IL-1\(\beta\) and MMP-8 points out the increased inflammatory status of the dialysis patient with PD, supporting the mutual connection of the two pathologies. p 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 12 2022 122 12 202 the cytokine and chemokine family, that control leucocytes and monocytes chemotaxis towards the kidney damaged site [5; 6]. On the other hand, CKD is associated with a poor immune status, determined either by the diseases that cause kidney failure (for example, diabetes mellitus and cardiovascular disorders), or uremia, or as a consequence of specific therapy (dialysis or transplant). This immuno-incompetence is the result of the process of non-compliant antigen recognition and antibody production, but also of impaired neutrophil function. By affecting the cellular or humoral mediated immune response, the host organism becomes ineffective in responding to bacterial aggressions [7]. Hence, CKD patients, especially those undergoing dialysis, develop an inadequate immune inflammatory response, that subsequently triggers infectious and thrombotic events which in turn create and maintain an added inflammatory burden [8]. Periodontal disease or periodontitis is defined as a multifactorial disorder, characterized by the disfunction of inflammation resolution pathways, which, in turn, leads to healing failure and a dominant chronic, progressive, destructive and irreversible inflammation upon periodontal level, with the consequent destruction of the attachment tissue and alveolar bone resorption [9; 10]. Gram-negative subgingival microorganisms (i.e., _Porphylomonas gingialis, Troponema denticola_ and _Tannerella forsythia_) play an essential role in inflammatory response, that subsequently determines the progression of periodontal injuries [11]. After the recognition and presentation of microbial antigens to immune-inflammatory cells, the cytokines of the innate immune response-tumor necrosis factor alpha (TNF-\(\alpha\)), interleukin IL-18, IL-6 are the first to be generated during the development of periodontal impairment [12]. Periodontitis is frequently diagnosed in patients with CKD [13; 14; 15; 16]. Based on the common inflammatory status, the relationship between periodontitis and CKD is an interesting avenue for the research of kidney disease progression. Literature indicates that periodontitis could be a potential risk factor for CKD [17; 18], through interferences in the immune response control, but no cause-effect has yet been proven. The concept of CKD patient predisposition towards periodontitis has also been taken into consideration, with both pros and cons.