_Applied_  
_sciences_  
_Keywords:_ MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. **Published:** MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. **C Copyright:** © 2021 by the authors. Licence MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([[https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)]([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/))). **Abstract:** Essential oils from different plant species were found to contain different compounds exhibiting anti-inflammatory effects with the potential to be a valid alternative to conventional chemotherapy that is limited in long-term use due to its serious side effects. Generally, the first mechanism by which an organism counteracts injurious stimuli is inflammation, which is considered a part of the innate immune system. Periodontitis is an infectious and inflammatory disease caused by a dysbiosis in the subgingival microbiome that triggers an exacerbated immune response of the host. The immune-inflammatory component leads to the destruction of gingival and alveolar bone tissue. The main anti-inflammation strategies negatively modulate the inflammatory pathways and the involvement of inflammatory mediators by interfering with the gene's expression or on the activity of some enzymes and so affecting the release of proinflammatory cytokines. These effects are a possible target from an effective and safe approach, suing plant-derived anti-inflammatory agents. The aim of the present review is to summarize the current evidence about the effects of essentials oils from derived from plants of the _Lamiaceae_ family as complementary agents for the treatment of subjects with periodontitis and their possible effect on the cardiovascular risk of these patients. **Keywords:** periodontitis; inflammation; oils; volatile; heart disease risk factors  
**1. Periodontitis**  
Periodontal disease is classically defined as a chronic inflammatory lesion, and gingivitis and periodontitis are the most common diseases derived from periodontitis involvement [1]. Periodontitis is a complex chronic inflammatory disease caused by Gram-negative anaerobic bacteria located in the subgingival biofilm [2], which can induce the production of inflammatory mediators, causing the destruction and loss of dental bone support [3]. Periodontitis is also described as an infectious disease which affects the tooth-supporting tissues and leads a numerous clinical, microbiological and immunological symptoms, associated with and, probably, induced by progressive interaction among infectious agents, host immune responses, hazardous environmental exposure and genetic predisposition [4]. Anaerobic bacteria are considered as periodontal pathogens, and the following have been highlighted: _Porhyromonas gingivalis_, _Aggregatibacter actinomycetemcomitans_, _Prevotella_intermediate, Tannerella forsythia_, Eikenella spp. and Capnocytophaga spp. However, it is important to highlight that those bacteria are mandatory for the disease development but are not enough and do not account for all cases of periodontitis [5]. The results of one survey in the USA indicate that chronic periodontitis affects about 46% of the adult population, with a higher prevalence among the elderly population [6]. This prevalence refers to the cohort of young adults according to the World Health Organization (WHO), aged 35 to 44 years. Interestingly, forms of periodontitis that occur at younger ages (before the age of 30 years), have other characteristics in addition to age and are known as aggressive periodontitis, with the prevalence ranging from 0.2% in Caucasians to 2.6% in Afro-Americans [7].