# CalculatetheROCcurve fpr,tpr,thresholds=roc_curve(expected,observed) roc_auc=auc(fpr,tpr)
PlottheROCcurve plt.figure() plt.plot(fpr,tpr,color='darkorange',lw=2,label='ROCcurve(area=%0.2f)'%roc_auc) plt.plot([0, 1], [0, 1],color='navy',lw=2,linestyle='--') plt.xlim([0.0, 1.0]) plt.ylim([0.0, 1.05]) plt.xlabel('FalsePositiveRate') plt.ylabel('TruePositiveRate') plt.title('ReceiverOperatingCharacteristic') plt.legend(loc=\"lowerright\") plt.show()
```

## 4 Discussion

It is possible to create a graphical user interface for data collection from patients under 15 years of age, and this allows us to have a complete picture of the current situation of the patient The development and training of the neural network contains the information for hospital admissions of the patients, as well as their family data, which allow us to determine the toxicity levels in methotrexate administration in patients with ALL who are younger than 15 years old, as observed in the learning curve in Figure 7, with statistical patterns established by the World Health Organization or by the doctors themselves. Patient differences in the pathophysiology of MTX neurotoxicity are complex because inhibiting DFR increases adenosine and homocysteine. Adenosine dilates cerebral blood vessels, delays the release of neurotransmitters in the pre-synaptic junctions, modifies the response after the synapse, and slows the neuronal discharge, which is manifested by headache, anorexia, vomiting, nausea, arterial hypertension, poisoning, vertigo, aphasia, agitation, lethargy, seizures, sensory depression, and coma. This neurotoxicity is usually associated with MTX-induced neurotoxicity or renal failure that leads to a poor outcome like in the sample shown by the authors of [23]. ## 5 Conclusions

Acute lymphoblastic leukemia is a condition suffered by children under 15 years old, with treatment presenting substantial progress to improve the life of children suffering from this disease. It was possible to design a graphical user interface to collect patient and family data to have a complete vision of the patient's current situation. The development and training of the neural network allow determining the levels of toxicity from methotrexate administration in patients with ALL with the help of statistical patterns established by the World Health Organization or by the physicians themselves, allowing access to the symptom characteristics depending on the morphological and risk classification of the ALL suffered by the patient. Once this classification is available, it will help the doctor decide the safety measures that must be taken within of the first 48 h after methotrexate administration. This development will help improve treatment monitoring and prevent frequent complications such as mucositis, as well as increase the life expectancy of patients. It will help reduce costs in the treatment follow-up by identifying the levels of methotrexate in patients. In conclusion, this article represents the impact on a vulnerable population due to economic, family, mobility, and housing situations at the time of having a patient with these characteristics. Conceptualization, A.M.S., J.A.O.T. and J.I.B.R. ; methodology, A.M.S., J.A.O.T. and J.I.B.R. ; sidu, A.M.S., J.A.O.T., J.B.R., J.A.G.R., J.M.VI. and G.F.A. ; formal analysis, A.M.S., J.A.O.T. and J.I.B.R. ; investigation, A.M.S., J.A.O.T. and J.I.B.R. ; resources, A.M.S. ; data curation, A.M.S., J.A.O.T. and J.I.B.R. ; writing--original draft preparation, A.M.S., J.A.O.T. and J.I.B.R. ; writing--review and editing, A.M.S., J.A.O.T., J.I.B.R., J.A.G.R., J.M.VI. and G.F.A. ; visualization, A.M.S., J.A.O.T., J.I.B.R., J.A.G.R., J.M.V.I. and G.F.A. ; supervision, A.M.S. ; project administration, A.M.S. ; funding acquisition, A.M.S., J.A.O.T., J.I.B.R., J.A.G.R., J.M.V.I. and G.F.A. All authors have read and agreed to the published version of the manuscript. The research was funded by the authors and some of the institutions where the authors themselves are employed.