## 1 Introduction  
At the European level, the REACH (Registration, Evaluation, Authorization, and Restriction of Chemicals), was created to protect human/animal health and the environment from chemicals. REACH is intended not only to mitigate the environmental damage that new compounds can cause, but also to protect human health. European companies and industries have been forced to incorporate this type of regulation into their manufacturing and industrialization processes since its implementation (1 June 2007). Currently, there are more than 80,000 chemical substances registered for use in Europe. REACH applies to all chemical substances: those involved in industrial processes and those that are present in objects in our daily life, such as cosmetics, including sun creams [1,2].  
According to Commission Regulation 2018/605 amending the Plant Protection Regulation No. 1107/2009 adopted by the European Commission, a substance shall be considered as having endocrine disrupting activity in humans if: it shows an adverse effect in an intact organism or its progeny leading to functional changes; it has an endocrine mode of action (anti-estrogenic, androgenic or anti-androgenic activity, steroidogenesis alteration and thyroid and anti-thyroid hormone activity); the adverse effect is a consequence of the endocrine mode of action [3]. The Endocrine Society and the World Health Organization(WHO) define an endocrine-disrupting chemical (EDC) as \"an exogenous substance or mixture that alters function (s) of the endocrine system and consequently causes adverse health effects in an intact organism, or its progeny, or (sub)populations\" [4; 5]. There are many harmful effects that EDC can have on health at any age, such as malformations and/or malfunction of the reproductive system, obesity, and cancer [6; 7; 8; 9], in particular hormone-dependent cancers (such as breast, endometrium, prostate, testis, and thyroid) [6].  
Endogenous hormones and EDCs share many structural similarities which may lead to hormone-dependent cancers interfering with hormone receptor function [10]. Parabens (methylparaben, butylpraben, ethylparaben, propylparaben, isopropylparaben, Isobutylparaben, benzylparaben) are an example of EDCs [11]. There is an important link between alterations of reproductive and metabolic health as a result of EDC exposure, such as from bisphenol A, bisphenol S, bisphenol F, phthalate metabolites, and mercury [6; 7; 8; 10].  
Sun creams are made up of three main ingredients. The excipients that create the cream or vehicle, the additives, preservatives, and other active substances, and finally the sun cream filters. The safety of UV filters for humans and the environment has been questioned recently. It has been studied that these filters can be harmful to the skin because when they come into contact with sunlight, they degrade and produce reactive oxygen substances that generate oxidative stress in skin cells, damage to genetic material, premature aging, and predisposition to skin cancer [12]. Multiple investigations reveal the presence of UV filters in human biological tissues [13; 14].  
It is important that sunscreens have some requirements to be safe for use in vivo: they must not be absorbed through the skin or if they do so, only in the stratum corneum, must not act as an EDC, must not have other effects different from the above, must not favor the absorption of other chemical substances, must be photostable, must not cause allergies or photosensitivity, must not be bioaccumulative, and must be easily degradable and not effect flora and fauna. Thus, the ideal photoprotector would meet all these requirements, have adequate cosmetic effects, and not have harmful effects on health [15]. Could it be possible?  
The objective of this research is to compare sun cream filters used in conventional commercial sunscreens and those that are considered natural products.