###### Abstract  
Reduction of the wound healing time after surgical procedures along with good hemostasis, and the reduction of post-surgical edema, pain and infective complications are generally desirable to both clinicians and patients. Recently, a gel compound containing sodium hyaluronate and four synthetic aminoacids (glycine, leucine, proline, lysine) and marketed as Aminogam(r) (Errekappa Euroterapici, Italy), has been proposed as a medical device promoting faster wound healing after oral surgery procedures. To assess its achievable clinical benefits, we studied retrospectively 580 cases (290 study cases and 290 control cases) undergoing oral surgery and receiving Aminogam(r) gel application. More precisely, cases were divided into 7 groups on the bases of the kind of surgery (teeth extraction, oral surgery in patients taking bisphosphonates, surgical treatment of jaw osteeencrosis related to bisphosphonates therapy, placement of endosseous implants, diode laser surgery of oral mucosa lesions with second intention healing without stitches, diode laser photocogaulation of slow flow vascular malformations and bone surgery). In all instances, Aminogam(r) gel was applied at least five times a day until the wound healed completely. We compared the elapsed time between surgery and complete healing with Aminogam(r) application compared to control cases receiving no other drug treatment. Our results confirmed that the overall time of healing is certainly reduced in cases receiving Aminogam(r) gel regardless of the kind of oral surgery.  
wound healing; faster healing; oral cavity; sodium hyaluronate; aminoacids +
Footnote †: journal: Applied  
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clinicians and patients. Wound healing is a specific and crucial biological process characterized by consecutive phases starting with angiogenesis and followed by fibroblast proliferation and differentiation, deposition of the extracellular matrix (ECM) and final re-epithelialization [1; 2; 3]. Fibroblasts and macrophages are both involved in the healing process. Fibroblasts promote neo-angiogenesis, secrete all ECM components (glycosaminoglycans, proteoglycans, glycoproteins and collagens) and produce several cytokines and growth factors [4]. Macrophages digest and kill bacterial pathogens, clean tissue debris and secrete a variety of chemotactic and growth factors [5; 6]. Hyaluronic acid is a glycosaminoglycan composed of repeating disaccharide units of D-glucoronate and N-acetyllylglucosamine, which is one of the most abundant constituents of the ECM, and is also involved in developmental processes such as cell proliferation, differentiation and motility [7; 8; 9]. Its effectiveness in favoring wound repair has been previously described in literature [1; 7]. Moreover, it is generally accepted that because of the increased metabolic activity, a large availability of aminoacids is necessary on site during the wound repair process [10]. On such bases, Aminogam(r) gel has been formulated as containing sodium hyaluron with the addition of four synthetic aminoacids (glycine, leucine, proline, lysine) to increase their availability in the surgical site. In previously published studies, authors have already demonstrated that Aminogam(r) gel promotes a faster healing of oral soft tissues after surgery and reduces post-surgical complications [1; 11] by neo-angiogenesis and fibroblasts' activity stimulation, thus inducing neo-collagenogenesis and ECM deposition.  
On these bases, we performed the current retrospective study on 580 cases in order to confirm on a larger sample the effectiveness of Aminogam(r) to promote faster healing of oral soft tissues after different surgical procedures in the oral cavity.