## 5 Conclusions  
Our study revealed that patients with decompensated HF (class IV NYHA HF and acute pulmonary edema) had higher MPV values than patients with stable HF (class II NYHA HF), and that, by applying regression model analysis, we could estimate the probability of a negative event happening in HF patients (3- or 6-month rehospitalization, increased length in-hospital stay, 1-year mortality) based on the MPV value. Therefore, MPV could be a potential negative predictor in HF patients. Conceptualization, A.C. and C.L.A. ; methodology, A.C.; software, O.C. ; validation, A.C. and C.L.A. ; formal analysis, A.C.; investigation, A.C.; resources, A.C. and C.L.A. ; data curation, A.C.; writing--original draft preparation, A.C. and C.L.A. ; writing--review and editing, A.C. and C.L.A. ; visualization, C.J.S. and C.L.A. ; supervision, C.J.S. and C.L.A. All authors have read and agreed to the published version of the manuscript. This research received no external funding. This study was conducted according to the guidelines of the Declaration of Helsinki. Our research in the hospital and data extraction from the hospital archive was approved by the Medical and Health Services Manager of Bagdasar-Arseni Emergency Hospital. Throughout our study, we did not risk creating emotional or physical harm to the patients since our research only entailed data collection and data analysis from the medical sheets and from the hospital's medical informatics system. Our study was conducted under the specific guidelines of the Ethical Committee of the University of Medicine and Pharmacy \"[PERSON]\", Bucharest which states that, since this is a non-interventional study that only entails data collection, ethical approval is not required. Therefore, ethical review and approval were waived for this study as it used existing patient data. The Ethical Committee of the University of Medicine and Pharmacy \"[PERSON]\", Bucharest requires ethical approval only for interventional studies (experimental procedures/medications that involve humans or animals). Please see the guidelines in the following link: [[https://umfcd.ro/wp-content/uploads/2021/NORME_ETICE_PRIVIND_CERCRETAREA_STINNTIFICA/PO%2035%20](https://umfcd.ro/wp-content/uploads/2021/NORME_ETICE_PRIVIND_CERCRETAREA_STINNTIFICA/PO%2035%20) Desf%]([https://umfcd.ro/wp-content/uploads/2021/NORME_ETICE_PRIVIND_CERCRETAREA_STINNTIFICA/PO%2035%20](https://umfcd.ro/wp-content/uploads/2021/NORME_ETICE_PRIVIND_CERCRETAREA_STINNTIFICA/PO%2035%20) Desf%)  
* [PERSON] et al. (2007) [PERSON]; [PERSON]; [PERSON]. Platelet activation in acute, decompensated congestive heart failure. _Thromb. Res._**2007**, _120_, 709-713. [CrossRef] [PubMed]
* [PERSON] et al. (2015) [PERSON]; [PERSON]; [PERSON] Correlation between mean platelet volume and B-type natriuretic peptide concentration in emergency patients with heart failure. _Biochem. Med._**2015**, _25_, 97-102. [CrossRef] [PubMed]
* [PERSON] et al. (2017) [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON] Mean Platelet Volume as a Predictor of Heart Failure-Related Hospitalizations in Stable Heart Failure Outpatients with Sinus Rhythm. _Acta Cardiol. Sin._**2017**, _33_, 292-300. * [PERSON] et al. (2011) [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON] The prognostic value of mean platelet volume in decompensated heart failure. _Emerg. Med. J._**2011**, _28_, 575-578. [CrossRef] [PubMedMed]
* [PERSON] et al. (2023) [PERSON] [PERSON]; [PERSON] [PERSON]; [PERSON] [PERSON]; [PERSON]; [PERSON] [PERSON]; [PERSON]; [PERSON]; [PERSON] [PERSON]; [PERSON]; [PERSON]; et al. Mean Platelet volume: A prognostic marker in heart failure with preserved ejection fraction. _Platelets_**2023**, _34_, 2188965. [CrossRef] [PubMed]
* [PERSON] et al. (2021) [PERSON]; [PERSON]; [PERSON] [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON]; et al. The impact of platelet indices on clinical outcomes in heart failure: Results from MyoVasc study. _ESC Heart Fail._**2021**, \(8\), 2991-3001.