## Materials and Methods
### Procedure  
Firstly, a surface electromyography (sEMG) of the anterior temporal and masseter muscles was performed by using the occlusal contact analyzer software called Teethan (BTS S.p.A., Garbagnate Milanese, Milan, Italy) (Figure 1), which consists of 4 wireless probes and an acquisition frequency of 1 kHz. This recording was set as T0 data. Then, the subjects were assigned to two different groups: the study group (a) (12 subjects: 3 males 9 females, mean age \(42.17\pm 7\) years) was treated using a computer-aided designed and CAD/CAM milled (digital) mockup and a control group (b) (10 subjects: 2 males, 8 females; mean age \(42.2\pm 10.5\) years) treated using a conventional technique (traditional) mockup. (a) Computer-aided designed/manufactured mockup (digital mockup)  
An intraoral scanner (Intra-oral scanner 3D Progress, M.H.T. s.r.I, Verona, Italy) was used to get intraoral digital impressions of the maxillary and mandibular arches while the mouth was open and in static occlusion. Intraoral scans in.stl format were used to design the mockup using Zirkonzahn.software with virtual articulator (Zirkonzahn s.r.l., Gais, Bolzano, Italy) and milled in PMMA (Bredent s.r.l., Bolzano, Italy), using a milling unit (M1 wet, Zirkonzahn s.r.l., Gais, Bolzano, Italy) (Figures 2 and 3). Then, the milled mockup was positioned in the patient's mouth, and at this time another sEMG recording was taken to detect the electrical potentials of the masticatory muscles (this recording was considered in T1). Figure 2 represents all the stages of the digital mockup preparation. In cases where the mockup was not perfectly stable the sEMG data did not document an adequate occlusal symmetry index; so, a touch-up was performed on the same mockup, to improve its stability. Then, a new sEMG recording was accomplished (T1b). Once the desired result was obtained, the definitive mockup was used as the temporary prosthesis. Figure 1: Image of a surface electromyographic exam ([PERSON], BTS S.p.A., Garbagnate Milanese, Milan, Italy). Figure 3: The images represent all the stages of the creation of the digital mockup, from design to insertion in the mouth. Figure 2: Occlusal, labial/facial and lingual views of the mockup obtained with a digital technique. (b) Conventional technique (traditional mockup)  
Initially, alginate impressions of both upper and lower arches were taken. The overjet and the overbite were then evaluated, and phonetic tests were performed to establish the right length of the central and lateral upper incisors, on which the composite-up (made with Ivoclar Vivadent composite) were bonded to establish the necessary elongations of the clinical crown. Then, a wax was modelled to register the OVD after the composite-up had been placed. This wax represents the OVD to be replicated during the prosthetic rehabilitation procedure. To model the wax, the patient was asked to slowly open the mouth starting from his/her habitual occlusion, freely following his/her usual opening/closing path. The patient was asked to repeat this habitual movement for at least 2-3 times, without placing any wax inside the mouth. Then, in order to register the wax bite, it was anchored on the upper arch (leaving the edge of the upper incisors, reconstructed with composite-up, visible to the patient through a frontal mirror), and the patient was asked to close his/her mouth slowly, respecting his/her usual path without reaching the end of the run, but letting the clinician to establish the stop-point. The clinician established the stop-point of the closing path, with respect to the overjet and overbite values and functional movements of the mandible. For the wax bite, a red wax sheet (Tenatex, Kermdent, Swindon Wiltshire, United Kingdom) was used, rebased with Aluwax (Aluwax Dental Products Co., Allendale, Michigan, USA), folded several (2-3) times based on the patient's need, until the alleged OVD was obtained (Figure 4). Figure 4: Traditional mockup and wax.