## 3 Results
### CBCT Analysis  
Mean + SD and minimal and maximal values for each ROI in OI-I patients and age matched HSs before and after extraction are shown in Table 2. As no significant statistically differences were observed for the different ROIs between the left (ROI-1, -3, -5 and -7) and right (ROI -2, -4, -6 and -8) side in the CBCT performed either before or after third molar extraction, the comparative analysis was performed combining data obtained at the same ROIs independent of laterality (i.e., ROI-1/-2, ROI-3/-4, ROI-5/-6 and ROI-7/-8).  
Before third molar extraction, no significant differences were observed between OI-I patients and age-matched HSs (Figure 2). In contrast, after the extraction, a significant statistical difference was observed for ROI-1/-2 (Figure 2A), ROI-3/-4 (Figure 2B) and for ROI-7/-8 (Figure 2D) with greater mean values for OI-I patients compared to age-matched HSs (OI-I vs. age-matched HSs; ROI-1/-2: 453.30 \(\pm\) 149.30 vs. 323.35 \(\pm\) 106.52, \(p\) = 0.0464; ROI-3/-4: 640.69 \(\pm\) 151.57 vs. 387.14 \(\pm\) 122.44, \(p\) = 0.0037; ROI-7/-8: 1689.96 \(\pm\) 157.56 vs. 1397.48 \(\pm\) 152.96, \(p\) = 0.0079). A statistically significant increase in the ROI values was observed after third molar extraction in OI-I patients (pre- vs. post-extraction: 284.73 \(\pm\) 148.67 vs. 453.30 \(\pm\) 149.30, \(p\) = 0.0039) for ROI-1/-2 (Figure 2A) and in both OI-I patients (pre- vs. post-extraction: 336.76 \(\pm\) 207.24 vs. 640.69 \(\pm\) 151.57, \(p\) = 0.0039) and age-matched HSs (pre- vs. post-extraction: 308.96 \(\pm\) 83.32 vs. 387.14 \(\pm\) 122.44, \(p\) = 0.0234) for ROI-3/-4(Figure 2B). As a result of post hoc power analysis, adequate power was limited to ROI-3/-4 and ROI-7/-8 after extraction in the inter-group analysis (0.930 and 0.941, respectively) and to ROI-1/-2 and ROI-3/-4 in both OI-I (0.877 and 0.999, respectively) and HSs (0.864 and 0.953, respectively).  
\begin{table}
\begin{tabular}{c c c c c c c c} \hline  & & \multicolumn{2}{c}{**OI-I**} & \multicolumn{4}{c}{**HSs**} \\  & & \multicolumn{2}{c}{**Mean \(\pm\) SD**} & \multicolumn{4}{c}{**Mean \(\pm\) SD**} \\  & & \multicolumn{2}{c}{**(Minimum-Maximum)**} & \multicolumn{4}{c}{**(Minimum-Maximum)**} \\ \hline  & **N** & **Pre** & **N** & **Post** & **N** & **Pre** & **N** & **Post** \\ \hline \multirow{2}{*}{**ROI-1**} & \multirow{2}{*}{4} & 309.36 \(\pm\) 211.21 & \multirow{2}{*}{4} & 467.73 \(\pm\) 194.53 & \multirow{2}{*}{4} & 288.43 \(\pm\) 65.90 & \multirow{2}{*}{4} & 338.86 \(\pm\) 135.68 \\  & & (160.05–612.56) & & (244.12–717.25) & & (207.24–349.47) & & (183.15–514.28) \\ \hline \multirow{2}{*}{**ROI-2**} & \multirow{2}{*}{5} & 265.03 \(\pm\) 98.28 & \multirow{2}{*}{5} & 441.77 \(\pm\) 125.81 & \multirow{2}{*}{4} & 243.32 \(\pm\) 74.76 & \multirow{2}{*}{4} & 307.85 \(\pm\) 86.16 \\  & & (157.67–418.77) & & (337.57–640.03) & & (176.18–310.62) & & (206.24–417.03) \\ \hline \multirow{2}{*}{**ROI-3**} & \multirow{2}{*}{4} & 346.04 \(\pm\) 248.57 & \multirow{2}{*}{4} & 684.75 \(\pm\) 120.65 & \multirow{2}{*}{4} & 314.76 \(\pm\) 75.25 & \multirow{2}{*}{4} & 347,70 \(\pm\) 46.64 \\  & & (180.52–705.95) & & (529.37–793.10) & & (206.29–370.83) & & (337.73–392.61) \\ \hline \multirow{2}{*}{**ROI-4**} & \multirow{2}{*}{5} & 337.49 \(\pm\) 214.65 & \multirow{2}{*}{5} & 605.44 \(\pm\) 177.59 & \multirow{2}{*}{4} & 303.15 \(\pm\) 102,20 & \multirow{2}{*}{4} & 426.58 \(\pm\) 169.28 \\  & & (161.22–680.85) & & (349.71–772.23) & & (206.62–398.88) & & (237.00–615.32) \\ \hline \end{tabular}
\end{table}
Table 2: Descriptive statistics for all ROIs from OI-I adolescents and age-matched HSs before and after third molar extraction.  
Figure 2: Graphical representation of ROI values from the same regions of the left and right side [ROI-1/-2 (**A**), ROI-3/-4 (**B**), ROI-5/-6 (**C**) and ROI-7/-8 (**D**)] from OI-I patients and age-matched HSs. Mean \(\pm\) SD and statistically significant differences between different groups are shown. Data are expressed as HU for each ROI.