## 1 Introduction  
The circular economy is based on the principles of reducing, reusing, recycling, and recovering materials, as well as repurposing waste by interconnecting water, food, and energy resources [1]. Industrial by-products and biowaste have been increasingly recognized as sustainable sources of phytochemicals, which can be valorized into bioactive compounds [2]. Among these, grape pomace, a by-product of the winemaking process, has attracted particular attention. Traditionally used as animal feed or fertilizer, grape pomace has been acknowledged for nearly four decades as a potential source of bioactive compounds, offering an additional strategy to mitigate environmental pollution [3]. Comprising a mixture of grape skins, seeds, and stems, it accounts for approximately 20% of the weight of processed grapes. Since the winemaking process does not extract all the valuable compounds, grape pomace remains rich in polyphenols, although their distribution is inhomogeneous [4; 5; 6]. Consequently, it can be efficiently transformed into cost-effective raw materials for industries such as cosmetics, nutraceuticalals, pharmaceuticals, and food, thus, reducing the environmental impact associated with waste disposal near wine production facilities [7]. The vinicitation process generates substantial amounts of waste; however, scientific and technological advancements have identified methods to recover these materials, sometimes yielding greater economic benefits than those derived from wine production itself [8]. The potential of these compounds in terms of application is essentially focused on their capacity for significant, widely demonstrated antioxidant and anti-inflammatory properties [9; 10; 11; 12], which renders them suitable for the treatment of inflammatory skin diseases. Inflammatory skin diseases are distinguished by the release of pro-inflammatory cytokines (e.g., TNF-alpha, IL-6, IL-12) and persistent oxidative stress (ROS release), which contributes to structural skin damage [13]. Among different grape varieties, Magliocco Calabrese pomace has been identified as particularly rich in phenolic compounds with diverse physiological properties, including antiallergenic, anti-inflammatory, antimicrobial, antioxidant, antithrombotic, cardioprotective, and vasodilatory effects [14; 15]. Furthermore, it has been largely demonstrated that anthocyanins, which are present in abundance in grape pomace, exhibit significant UV-shielding properties, thereby mitigating photoaging by reducing oxidative stress and collagen degradation [16; 17]. However, the efficacy of these phenolic extracts largely depends on maintaining their stability, bioactivity, and bioavailability [18]. To enhance their preservation, various encapsulation strategies have been proposed, including the use of maltodextrin, primarily in the food industry [19]. Building upon these findings, the present study aims to expand on previously employed methods [20] by focusing on:  
1. the reuse of waste raw materials, thereby promoting a circular economy through waste reduction and repurposing;
2. the application of rapid dynamic solid-liquid extraction (RSLDE, Naviglio(r)) to maximize the preservation of bioactive compounds [21];
3. the grafting of polymers in an aqueous environment, using dextran--a natural, biocompatible, and biodegradable polysaccharide--due to its moisturizing, film-forming, and carrier properties. Its biocompatibility and chemical stability make it particularly suitable for various applications, protecting active ingredients from degradation [22; 23; 24; 25; 26]. The novelty of this study lies in the choice of grape marc as the raw material of interest, exploiting its various components with multifunctional bioactive properties. Instead of being discarded, this material can be extracted and incorporated into technologies that have a controlled release system and that reduce its degradation by increasing its stability.