## 7 Applications
Four acrylates were studied: ethylene glycol dimethacrylate (EGDM), pentaerythnitol triacrylate (PETA), triethylene glycol diacrylate (TEGDA), and trimethylolpropane triacrylate (TMPTA). Five different types of FPSE membrane coated with different sol-gel sorbents were studied, and finally sol-gel polyethylene glycol-polypropylene glycol-polyethylene glycol triblock copolymer (PEG-PPG-PEG) coated FPSE membrane was chosen for its satisfactory results combined with methanol for back-extraction since it provided an elution ability slightly higher than acetonitrile. Under the optimized conditions, the method provided limits of detection of the compounds in the range of (0.1-1.9 ng g\({}^{-1}\), 0.1-1.2 ng g\({}^{-1}\), 0.2-2.3 ng g\({}^{-1}\)) in EtOH 10%, HAc 3%, and EtOH 20%, and the enrichment factor values (EFs) after applying N\({}_{2}\) were in the range of 11.1-25.0, 13.8-26.3, 8.3-21.9, in simulants A, B, and C, respectively. The optimized method was applied successfully to analyze thirteen types of recycled PET samples. [PERSON] et al. in 2019 [10] developed a simple and sensitive analytical methodology for rapid screening and quantification of selected estrogenic endocrine disrupting chemicals including \(\alpha\)-estradiol, hexestrol, estrone, 17\(\alpha\)-ethinyl estradiol, diethylstilbestrol, and bisphenol A from intact milk using fabric phase sorptive extraction in combination with high-performance liquid chromatography coupled to ultraviolet detection/tandem mass spectrometry. The new approach eliminates protein precipitation and defatting step from the sample preparation workflow, while the error prone and time-consuming solvent evaporation and sample reconstitution steps have also been eliminated. Parameters which mostly affect the extraction efficiency of fabric phase sorptive extraction, including sorbent chemistry, sample volume, and extraction time, were optimized. The limit of detection values obtained in fabric phase sorptive extraction with high-performance liquid chromatography with ultraviolet detection ranged from 25.0 to 50.0 ng/mL. Two sol-gel sorbent coatings were tested to determine the better sorbent coating for the selected EDCs, sol-gel PTHF, and sol-gel PDMS. Sol-gel PTHF was distinctly superior in extraction efficiencies for all compounds, with acetonitrile used for back extraction. [PERSON] et al. in 2019 [47] developed a method for the quantification of highly potent analgesic agent (2\(R\),4\(R\),7\(R\),8_A_R_)-4,7-dimethyl-2-(thiophen-2-yl)octahydro-2_H_-chromen-4-ol in rat whole blood and plasma using dried matrix spots (DMS) and fabric phase sorptive extraction (FPSE) techniques in combination with LC-MS/MS. The linearity was obtained in the range of 20-5000 ng/mL and 50-5000 ng/mL for plasma-FPSE and blood-FPSE experiments, respectively. The mean extraction recovery (%) was 26 for plasma-DMS, 25 for blood DMS, 38 for plasma-FPSE, and 31 for blood-FPSE. A sol-gel PCAP-PDMS-PCAP sorbent-coated FPSE biofluid sampler FPSE blood sampler was compared to a DBS card and has been used under a different sampling and extraction mode (DBS card with direct spotting, and FPSE biofluid sampler with equilibrium extraction mode); both perform satisfactorily with different sample matrices. However, the FPSE biofluid sampler was found more selective in preparing an interferents-free sample for instrumental analysis. Due to the exploitation of high-performance sol-gel sorbent, the FPSE biofluid sampler has the potential to streamline the current practice of blood analysis. [PERSON] et al. in 2019 [48] developed a fabric phase sorptive extraction (FPSE)-based sample preparation method for methyl paraben (MP), propyl paraben (PP), and butyl paraben (BP) in cosmetic and environmental samples, prior to high performance liquid chromatography-photodiode array (HPLC-PDA) detection. In the proposed method, MP, PP, and BP molecules were efficiently retained on a sol-gel Carbowax-20M sorbent-coated FPSE membrane when the matrix pH was adjusted to 5.