## 8 Conclusions and Future Prospective  
Wound healing is a complicated, multi-step, and dynamic process with several involved cells, biochemical molecules, and signaling pathways. Moreover, various endogenous and exogenous interfering factors affect the process, such as acute inflammatory responses, pathogenic contaminations, wound bed dryness, exudates, and oxygen permeability. The passive wound-healing/dressing biomaterials solely act as the physical structures, which prevent bacterial invasion and modulate the wound bed's moisture at the optimum situation. Many types of wounds, including an infected wound, diabetic ulcers, and burn wounds, required physical care and biological interventions, which are not accessible with the passive wound-healing/dressing biomaterials. Accordingly, bioactive interacting wound-healing/dressing biomaterials with different biological activities, such as antibacterial, antioxidant, and proliferative properties, are highly encouraged to improve and accelerate the wound-healing process.  
Cellulose-based biomaterials are attractive for wound-healing/care applications due to their diversity, tunable physical, chemical, mechanical, and biological performances, accessibility, low cost, and biocompatibility. Moreover, cellulose can be obtained from various bacteria, tunicates, and plants. Cellulose-based biocompatibility are fascinating for wound-healing/dressing materials because of their processability to multiple structures, such as nano/microfibers, hydrogels, films, and colloids. Their hydrophilic nature has been applied to modulate the performance of different natural and synthetic wound-healing/dressing materials. Various bioactive molecules such as antibiotics, vitamins, growth factors, peptides, and natural substances have been delivered to the wound site using cellulose-based structures. The biodegradation of cellulose-based biomaterials in the human body is challenging, which is not a big deal for wound-healing/dressing applications. They are easily removed from the wound bed after inducing the intended effect.  
The application of toxic crosslinking agents (e.g., GA) is a concerning issue for fabricating biocompatible cellulose-based hydrogels. Accordingly, the development of safe, efficient, and biocompatible crosslinking approaches is necessary for the production of hydrogel-based biomaterials with appropriate physicochemical and biological features. The combination of the cell therapy concept with cellulose-based wound-healing biomaterials as the cell-laden structures is promising to accelerate the healing process in chronic wounds. The authors believe that the combination of wound-healing and stem cell therapy may result in more efficient clinical outcomes. In this review, we discussed the studies conducted on cellulose-based biomaterials as the wound-healing material and highlighted their outcomes and drawbacks beneficial for the future direction of wound-care/healing approaches.  
Conceptualization, M.H. and C.D.; Writing--original draft preparation, M.F.A., S.G. and S.Z.K.; writing--review and editing, M.F.A., S.G., S.Z.K., N.H.B., D.A., S.P., H.D., Z.A., S.M.A., M.H. and C.D. All authors have read and agreed to the published version of the manuscript.  
There is no funding info for this manuscript.  
Authors earnestly acknowledge the support from the Nano Drug Delivery Research Center (NDDRC), Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran (Grant Number: 980959).  
The authors declare that they have no competing interests.