## 1 Introduction  
### The Technical Background of CDP Synthesis Technique and the Significance of Synthesizing PNDs  
Chemical vapor deposition (CVD) is a process in which the substrate is exposed to one or more volatile precursors that react and/or decompose on the substrate surface to create the desired thin film deposit [1]. Initiated chemical vapor deposition (iCVD) is a versatile technique that allows for solvent-free and completely dry vapor-phase deposition [2]. It offers numerous advantages, including the ability to achieve conformal and uniform fabrication over large surface areas. One of its key features is the real-time control it provides over the thickness and nanostructure of the deposited films [3]. In the field of nanomaterials synthesis, iCVD has garnered significant attention due to its superior capabilities in synthesizing various nanomaterials, including 1D, 2D, and 3D materials [4]. Specifically, in the realm of 1D materials, iCVD enables the fabrication of nanoparticles, nanowires, nanotubes, nanoribbons, and similar forms [5, 6, 7]. These materials possess unique properties and find extensive applications in electronics, energy storage, sensors, and biomedical engineering [8; 9; 10]. The solvent-free and dry nature of iCVD allows for precise control over the composition and structure of the deposited polymer films, eliminating the need for post-deposition solvent removal steps and reducing the risk of contamination. Substantial research has emerged on the utilization of iCVD for polymer film applications on various substrates [11; 12; 13; 14]. Notably, [PERSON] and her team have made significant contributions in this area, particularly in the field of conformal polymer coating technologies. They have provided detailed insights into the synthesis process and system construction of polymer CVD [15; 16; 17; 18; 19]. The integration of iCVD synthesis with functional material design has fostered a burgeoning interdisciplinary field that combines materials science with microbiology [20; 21]. This emerging field focuses on exploring the interactions between materials and microorganisms at the interface. In the realm of biological applications, the design of materials with optimal biocompatibility and fouling resistance is of paramount importance. Biocompatibility refers to the ability of a material to interact with living systems without causing adverse reactions, while fouling resistance refers to the material's ability to prevent the accumulation of biological substances on its surface. Achieving optimal biocompatibility and fouling resistance necessitates a deep understanding of the complex interactions between materials and microorganisms, as well as precise control over material properties at the molecular level. Polymer nanodomes (PNDs) offer significant potential in drug delivery. They serve as effective drug carriers, safely encapsulating drug molecules within their sturdy polymer structures, protecting them from environmental factors such as humidity and light. PNDs can be tailored for controlled drug release, gradually delivering drugs to target tissues or cells by adjusting their size, shape, and polymer properties to meet specific therapeutic needs. Additionally, PNDs can be surface-modified for targeted drug delivery, adhering selectively to specific cells or tissues, enhancing drug precision while minimizing impact on healthy tissues. PNDs are typically biocompatible, causing minimal adverse reactions in biological systems, making them valuable for in vivo applications [22; 23; 24; 25; 26]. Polymeric nanoparticles can be synthesized using various techniques, such as emulsification (solvent displacement or diffusion) [27]. The latest technique for obtaining semi-spherical polymeric nanoparticles involves their polymerization through the method of initiated chemical vapor deposition [28]. In fact, current technology has advanced to the point where it is possible to synthesize nanoparticles on substrates with various shapes, such as nanodroplets, hemispheres, and domed shapes.