# Antibacterialarial Agents Used in Modifications of Dental Resin Composites: A Systematic Review
## 2 Methods
### Article Selection
\begin{table}
\begin{tabular}{l c c c} \hline \hline \multicolumn{1}{c}{**Modification**} & \multicolumn{1}{c}{**Microorganisms**} & \multicolumn{1}{c}{**Results**} & \multicolumn{1}{c}{**References**} \\ \multicolumn{1}{c}{} & \multicolumn{1}{c}{**Tested**} & \multicolumn{1}{c}{**Results**} & \multicolumn{1}{c}{**References**} \\ \hline Myristyltrimethylammoniumium & & Antimicrobial activity against biofilm formation was obtained with 0.5 wt\%, & \\ Bromide (MYTAB) & _Streptococcus mutans_ & and activity against planktonic bacteria was obtained with 1 wt\% & \\ \hline
2.5 or 5 wt \% of the methacrylate & & The higher the TAT concentration, the & \\ monomer 1,3,5-triacylglycerollyhexahydro-1,3,5-triacylglycerol & _Streptococcus mutans_ & higher the antibacterial activity & [34] \\ triazine (TAT) & & & \\ \hline Methexylated chitosan (CH-MA) & _Streptococcus mutans_ & Reduction in biofilm formation & [35] \\ \hline
1,2,3-triazolamium-functionalized POSS & _Streptococcus mutans_ & The nanocomposite incorporating & \\ Triazolamium/POSS exhibited markedly & & & \\ elevated bactericidal activity & & \\ \hline Fluorinated dimechacrylate FDMA was & & & \\ mixed with triethylene-glycol & & & \\ dimethacrylate (TEGDMA) and & _Streptococcus mutans_ & The use of fluorinated methacrylate & \\ fluorinated diluent 1 H,1 & & & \\ H-heptafluorobutyl methacrylate (FBMA) & & & \\ \hline Copper(l)-catalyzed azide-alkyne & & Reduction in luciferase activity and the & \\ cycloaddition (CuAAC) & _Streptococcus mutans_ & number of viable bacteria recovered & [38] \\ \hline Nanoparticles of amorphous calcium & & & \\ phosphate (NACP) with & & & \\ dimethylaminobenzexadecyl methacrylate & _Streptococcus mutans_ & Reduction in biofilm growth & [39] \\ \hline Triethylene glycol divinylbenzyl ether & & & \\ (TEG-DVBE), and 3\% & & & \\ dimethylaminohexadecyl methacrylate & _Streptococcus mutans_ & Exhibited remineralizing and & \\ (DMATHDM), and 20\% calcium phosphate & & & \\ \hline Alkaline fillers (alkasite—alkaline fillers & & & \\ such as barium aluminum silicate glass & _Streptococcus mutans_ & The antibacterial effect of alkasite was & [41] \\ and ytterbium trifluoride) & & lesser than that of the control group & [41] \\ \hline Development of Chlorhexidine-loaded & _Streptococcus mutans_ & Significant antibacterial activity & [42] \\ halloysite nanotube & & & \\ \hline Core–shell chlorbaseline/amorphous & & 5 wt\% and more of CHX/ACP & \\ calcium phosphate (CHX/ACP) nanoparticles & _Streptococcus mutans_ & nanoparticles effectively inhibited the growth of _Streptococcus mutans_ & [43] \\ \hline Magnesium oxide nanoparticles (nMgO) & _Streptococcus mutans_ & Very good antibacterial properties & [44] \\ \hline Silver nanoparticle (AgNP)-laden HA (HA-PDA-Ag) nanowires & _Streptococcus mutans_ & High antibacterial activity & [45] \\ \hline Chitosan or chitosan loaded with dibasic calcium phosphate anhydrous & _Streptococcus mutans_ & The modified composites contained about 20\% less biofilm & [46] \\ (DCPA) particles & _Streptococcus mutans_ & Modification with 2\% TiO\({}_{2}\)/Ag & \\ \hline TiO\({}_{2}\) and TiO\({}_{2}\)/Ag nanoparticles & _Streptococcus mutans_ & nanoparticles significantly reduced biofilm accumulation & [47] \\ \hline Ag–TiO\({}_{2}\) filler particles & _Streptococcus mutans_ & Bactericidal effect (small quantities) & [48] \\ \hline Ag–doped sol–gel–derived bioactive glass (Ag–BG) & & As the concentration of Ag–BG in & \\  & & BGCOMP increases, the number of dead & [49] \\  & & bacteria in the biofilm increases & \\ \hline Ciprofloxacinacin–loaded silver & _Streptococcus mutans_, & Antimicrobial activity after CIP–AgNP & [50] \\ nanoparticles (CIP–AgNPs) & _Salisu microorganism_ & modification was increased & \\ \hline Commercial barium borosilicate-based & & & \\ glass powders immobilized with silver & _Streptococcus mutans_ & Strong and effective action & [51] \\ sulfadiazine filler & & & \\ \hline \hline \end{tabular}
\end{table} 
Table 2: _Cont._