## 3 Results
### Non-Targeted LC-QTOF-MS Based Metabolomics Data
\begin{table}
\begin{tabular}{c c c c} \hline \hline
**Precursor** & **EC Number** &
\begin{tabular}{c} **Is It Included in** \\ **CannGEM?** \\ \end{tabular} \\ \hline hphC; 3-benzylmalate isomerase & 4.2.1.- & No \\ \hline hphB; 3-benzylmalate dehydrogenase & 1.1.1.- & Yes \\ \hline xanB2; chorismate lyase/3-hydroxybenzoate synthase & 4.1.3.40 & No \\ \hline fkbO, rapK; chorismatase & 3.3.2.13 & No \\ \hline dss; 1-deoxy–xylulose-5-phosphate synthase & 2.2.1.7 & Yes \\ \hline dxr; 1-deoxy–xylulose-5-phosphate reductioisomerase & 1.1.1.267 & Yes \\ \hline isp; 2-C-methyl–erythritol 4-phosphate cytidylyltransferase & 2.7.7.60 & Yes \\ \hline ispE; 4-diphosphocytidyl-2-C-methyl–erythritol kinase & 2.7.1.148 & Yes \\ \hline ispF; 2-C-methyl–erythritol 2,4-cyclodextrin diphosphate synthase & 4.6.1.12 & Yes \\ \hline gcpE, ispG; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase & 1.17.7.1 & Yes \\ \hline ispH, lytB; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase & 1.17.7.4 & No \\ \hline ACAT, atob; acetyl-CoA C-acetyltransferase & 2.3.1.9 & Yes \\ \hline HMGCS; hydroxymethylglutaryl-CoA synthase & 2.3.3.10 & Yes \\ \hline HMGCR; hydroxymethylglutaryl-CoA reductase (NAPH) & 1.1.1.34 & Yes \\ \hline mvaA; hydroxymethylglutaryl-CoA reductase & 1.1.1.88 & No \\ \hline MVK, mvaK1; mexulonate kinase & 2.7.1.36 & Yes \\ \hline E2.7.4.2, mvaK2; phosphomevalonate kinase & 2.7.4.2 & Yes \\ \hline PMVK; phosphomevalonate kinase & 2.7.4.2 & Yes \\ \hline MV, mva; diphosphomevalonate decarboxylase & 4.1.1.33 & Yes \\ \hline pmd; phosphomevalonate decarboxylase & 4.1.1.99 & No \\ \hline ipk; isopentenyl phosphate kinase & 2.7.4.26 & No \\ \hline acnX1; mexulonate 5-phosphate dehydratase large subunit & 4.2.1.- & No \\ \hline K25518; trans-anhydromevalonate 5-phosphate decarboxylase & 4.1.1.- & Yes \\ \hline ubiX, bsdB, PA1; flavin prelytransferase & 2.5.1.129 & No \\ \hline E2.7.1.185; mexulonate-3-kinase & 2.7.1.185 & No \\ \hline E2.7.1.186; mexulonate-3-phosphate-5-kinase & 2.7.1.186 & No \\ \hline E4.1.1.110; bisphosphonate decarboxylase & 4.1.1.110 & No \\ \hline idi, II; isopentenyl-diphosphate elta-isomerase & 5.3.3.2 & Yes \\ \hline FPS; famesyl diphosphate synthase & 2.5.1.1 & Yes \\ \hline E2.5.1.68; short-chain Z-isoprenyl diphosphate synthase & 2.5.1.68 & No \\ \hline ZFPS; (Z2,6Z)-farnesyl diphosphate synthase & 2.5.1.92 & No \\ \hline E2.5.1.86; trans, polycis-decaprenyl diphosphate synthase & 2.5.1.86 & No \\ \hline E2.5.1.88; trans, polycis-polyphenyl diphosphate synthase & 2.5.1.88 & No \\ \hline hexPS, COQI; hexaprenyl-diphosphate synthase & 2.5.1.82 & No \\ \hline hexs-a; hexaprenyl-diphosphate synthase small subunit & 2.5.1.83 & No \\ \hline hepS; heptaprenyl diphosphate synthase component 1 & 2.5.1.30 & Yes \\ \hline ispB; octaprenyl-diphosphate synthase & 2.5.1.90 & No \\ \hline SPS, sds; all-trans-nonnpenryl-diphosphate synthase & 2.5.1.84 & Yes \\ \hline PSS1; decaprenyl-diphosphate synthase subunit 1 & 2.5.1.91 & No \\ \hline upPS; undecaprenyl diphosphate synthase & 2.5.1.31 & No \\ \hline NUS1; dehydrodolichy diphosphate synthase complex subunit NUS1 & 2.5.1.87 & No \\ \hline upPS, cpdS; tritrans, polycis-undecaprenyl-diphosphate synthase [gearanylgeranyl-diphosphate specific & Yes \\ \hline chlP, bchP; geranylgeranyl diphosphate/geranylgeranyl-bacteriochlorophyllide a reductase & 1.3.1.83 & No \\ \hline ispS; isoporene synthase & 4.2.3.27 & No \\ \hline \hline \end{tabular}
\end{table} 
Table 4: \(Cont.\)