# The Role of Platelet-Rich Plasma in the Management of Ankle Osteoarthritis: A Systematic Review
## Appendix A Search Strategies  
PUBMED AND MEDLINE SEARCH STRATEGIES  
1. \"Osteoarthritis\"[Mesh]
2. \"Osteoarthritis/etiology\"[Mesh] OR \"Osteoarthritis/rheobiology\"[Mesh] OR \"Osteoarthritis/pathology\"[Mesh] OR \"Osteoarthritis/rheabilitation\"[Mesh] OR \"Osteoarthritis/therapy\"[Mesh]
3. \"Ankle osteoarthritis\"
4. #1 OR #2 OR #3
5. \"Ankle\"[Mesh]
6. \"Ankle Joint\"[Mesh]
7. \"Ankle Injuries\"[Mesh]
8. #5 OR #6 OR #7
9. \"Platelet-Rich Plasma\"[Mesh]
10. \"Injections, Intra-Articular\"[Mesh]
11. \"PRP\"[mp]
12. #9 OR #10 OR #11
13. #4 AND #8 AND #12  
((\"Osteoarthritis\"[Mesh]) OR (\"Osteoarthritis/etiology\"[Mesh] OR \"Osteoarthritis/microbiology\"[Mesh] OR \"Osteoarthritis/pathology\"[Mesh] OR \"Osteoarthritis/rehabilitation\"[Mesh] OR \"Osteoarthritis/therapy\"[Mesh]) OR (\"Ankle osteoarthritis\")) AND ((\"Ankle\"[Mesh]) OR (\"Ankle Joint\"[Mesh]) OR (\"Ankle Injuries\"[Mesh])) AND ((\"Platelet-Rich Plasma\"[Mesh]) OR (\"Injections, Intra-Articular\"[Mesh]) OR (\"PRP\"[mp])) SPORT DISCUS SEARCH STRATEGY  
1. DE \"Osteoarthritis\"
2. \"Ankle osteoarthritis\"
3. DE \"Arthritis\"
4. #1 OR #2 OR #3
5. DE \"ANKLE\"
6. DE \"ANKLE injuries\"
7. DE \"ANKLE injury treatment\"
8. DE \"ANKLEBONE\"
9. DE \"ANKLEBONE injuries\"
10. #5 OR #6 OR #7 OR #8 OR #9
11. DE \"PLATELET-derived growth factor\"
12. DE \"PLATELET-rich plasma\"
13. \"PRP\"
14. DE \"Injections\"* [15] #11 OR #12 OR #13 OR #14
* [16] #4 AND #10 AND #15  
CINAHL SEARCH STRATEGY
* [1] MH \"Osteoarthritis\"
* [2] MH \"Arthritis\"
* [3] \"Ankle osteoarthritis\"
* [4] #1 OR #2 OR #3
* [5] MH \"Ankle\"
* [6] MH \"Talus\"
* [7] MH \"Ankle Joint\"
* [8] MH \"Ankle Injuries\"
* [9] #5 OR #6 OR #7 OR #8
* [10] MH \"Platelet-Rich Plasma\"
* [11] MH \"Platelet-Derived Growth Factor\"
* [12] \"PRP\"
* [13] MH \"Injections, Intraarticular\"
* [14] #10 OR #11 OR #12 OR #13
* [15] #4 AND #9 AND #14  
COCHRANE SEARCH STRATEGY
* [1] MeSH descriptor: [Osteoarthritis] explode all trees
* [16] MeSH descriptor: [Ankle Joint] explode all trees
* [17] MeSH descriptor: [Ankle] explode all trees
* [18] MeSH descriptor: [Platelet-Rich Plasma] explode all trees
* [19] MeSH descriptor: [Platelet-Derived Growth Factor] explode all trees
* [20] MeSH descriptor: [Injections, Intra-Articular] explode all trees
* [21] \"PRP\"
* [22] \"PRP\"
* [23  
* _[PERSON] et al. (2018)_ [PERSON]; [PERSON] [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON] on behalf of the EnCORE Research Group. Intra-articular Injections in the Treatment of Symptoms from Ankle Arthritis: A Systematic Review. _Foot Ankle Int._**2018**, _39_, 1141-1150. [CrossRef]
* [PERSON] et al. (2020) [PERSON]; [PERSON] [PERSON]; [PERSON]; [PERSON] The Use of Platelet-Rich Plasma and Stem Cell Injections in Musculoskeletal In Injuries. _Cureus_**2020**, _16_, e59970. [CrossRef] [PubMed]
* Thu (2022) [PERSON] The use of platelet-rich plasma in management of musculoskeletal pain: A narrative review. _J. Yeungnam Med. Sci._**2022**, _39_, 206-215. [CrossRef] [PubMed]
* [PERSON] et al. (2009) [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON] [PERSON]; [PERSON] The PRISMA Statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. _J. Clin. Epidemiol._**2009**, _62_, e1-e34. [CrossRef] [PubMed]
* [PERSON] et al. (2018) [PERSON] [PERSON]; [PERSON] [PERSON]; [PERSON]; [PERSON] [PERSON]; [PERSON] [PERSON] Efficacy of Platelet Rich Plasma in the Treatment of Ankle Joint Osteoarthritis. PROSPERO CRD42018085261. 2018. Available online: [[https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42018085261](https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42018085261)]([https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42018085261](https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42018085261)) (accessed on 27 September 2024). * Cochrane Effective Practice and Organisation of Care (EPOC) (2017) Cochrane Effective Practice and Organisation of Care (EPOC).