## 3 Results  
Visual observation of the animals showed that the rats of the first (control) group were more sluggish than in the experimental groups. The scab in group II of animals after OOM treatment was lighter and more elastic. In animals of group III, which underwent subcutaneous pricking with a gas mixture, the amount of wound discharge was significantly less than in animals of groups I and II. In the experimental groups, by seven days after the injury, signs of wound healing were noted (the edges of the scab began to rise, foci of marginal epithelization appeared). In the control group, such signs appeared only by the 10 th day. In animals of group II, active rejection of the scab began three days earlier than the control. According to the results of histological examination, it was found that the first day after the injury, the histological picture in the edges of wounds in animals of all three groups had no differences (Figure 1). In all preparations, there is a lesion of the epidermis (necrosis and necrobiosis), dermis (papillary and mesh layers), manifested by the loss of the usual fibrous structure of the connective tissue of the dermis and transformation collagen fibers into a solid homogeneous mass, as well as edema and hemorrhages in loose connective tissue and adipose tissue located above the layer of the skin's own muscle. Figure 1: Histological picture of the wound on the first day after the burn (typical picture for rats of all groups). Deep burn with necrosis of the epidermis, papillary and mesh layers of the dermis, as well as necrobiosis of the muscle fibers of the skin’s own muscle. Stained with hematoxylin and eosin. The blood vessels passing through here are often also necrotic, containing red blood clots. The muscle fibers of the skin's own muscles are in a state of dystrophy: swollen, often vacuolated. There are no cores in individual fibers. In the loose connective tissue located under the muscle layer, there is fullness, puffiness, as well as an increased number of cells, among which leukocytes and macrophages predominate. Seven days after the injury, the animals in the wounds of the control group (treatment with Levomecol) showed a picture of inflammation with initial signs of healing (Figure 2). The wound is covered with a scab, which consists of necrotized tissues (epidermis, dermis), and in the center of the wound, where the burn was deepest, its own muscle is included in its skin. On the periphery, closer to the edges of the wound, approximately in the middle of the thickness of the dermis, a pronounced leukocyte demarcation shaft is found, which divides the dermis into three parts--upper, necrotized, and lower--with manifestations of regeneration in the form of proliferation of epithelial cells in the course of pre-existing hair follicles and initial manifestations of marginal epithelialization of the wound, foci of fibroblast proliferation in the dermis with the appearance of newly formed collagen fibers and thin-walled blood vessels, and in muscle tissue against the background of dystrophically altered, and even necrotized muscle fibers with the phenomena of sarcoplasm decay are sometimes found as manifestations of regeneration in the form of muscle kidneys. Proliferation of myocyte nuclei is noted along the periphery of a significant part of viable muscle fibers. In addition, fibroblasts proliferate between muscle fibers. In the loose connective tissue under the skin's own muscle, there is a proliferation of connective tissue cells in these areas. Seven days after the injury, in the group of animals whose wounds were treated with ozonated oil, purulent inflammation prevails, which is noted in the form of purulent exudate on the wound surface among the necrotic epidermis and under it, as well as in the form of focal purulent infiltrates in the necrotic dermis (Figure 3). A continuous demarcation shaft is not formed, but, nevertheless, its placement in the dermis is indicated by leukocyte infiltrates located, albeit discretely, but at a short distance from each other.