# Adipolin, Chemerin, Neprilysin and Metabolic Disorders Associated with Obesity
## 3 Results  
### Comparative Analysis of Assessed Parameters  
Anthropometric parameters, metabolic parameters, blood pressure values, and adipokine concentrations in the group with and without obesity and in the group with normal and abnormal glucose tolerance were summarized. Statistical analyses were also carried out, taking gender into account.  
Obese subjects had statistically significantly higher fasting glucose and insulin levels and a higher HOMA-IR than non-obese subjects. In addition, obese people had higher triglyceridemia and higher blood pressure values but lower HDL-C levels. Other parameters analyzed, including adipokine concentrations, were comparable (Table 2).  
Comparing the results of obese subjects with NGT or AGT, there was a marked difference in glycemia at 120\({}^{\prime}\) of OGTT [mmol/L] (5.72 \(\pm\) 1.20 vs. 9.49 \(\pm\) 2.26, \(p\) < 0.001) insulinemia [mU/mL] (5.20 \(\pm\) 0.42 vs. 6.21 \(\pm\) 0.93, \(p\) < 0.001) and HOMA-IR 2.33 (1.80; 3.45) vs. 4.00 (2.72; 5.63) \(p\) < 0.001 and systolic blood pressure values 140.00 (135.00; 146.25) vs. 150.00 (140.00; 165.00) [mmHg] \(p\) = 0.038. The values of the other parameters analyzed, i.e., lipid metabolism exponents and DBP, were similar [14]. There were also no differences between the concentrations of the analyzed adipokines in these groups (Figure 1A-C).  
\begin{table}
\begin{tabular}{l c c c} \hline  & **Obesity** & **No Obesity** & \(p\) \\  & **(_n = 51_)** & **(_n = 37_)** & \(p\) \\ \hline Fasting glucose [mmol/L] & 5.65 (5.15; 6.12) & 4.99 (4.55; 5.38) & \textless{}0.001 \\ \hline Fasting insulin [μU/L] & 12.3 (8.95; 18.45) & 6.4 (4.1; 8.4) & \textless{}0.001 \\ \hline HOMA-IR & 3.12 (2.22; 4.38) & 1.37 (0.91; 1.92) & \textless{}0.001 \\ \hline Total cholesterol [mmol/L] & 5.58 \(\pm\) 1.35 & 5.33 \(\pm\) 0.86 & 0.339 \\ \hline Triglycerides [mmol/L] & 1.89 (1.38; 2.67) & 1.06 (0.78; 1.38) & \textless{}0.001 \\ \hline LDL cholesterol [mmol/L] & 3.67 (2.83; 4.38) & 3.31 (2.66; 3.90) & 0.124 \\ \hline HDL cholesterol [mmol/L] & 1.11 (0.94; 1.30) & 1.78 (1.34; 1.94) & \textless{}0.001 \\ \hline SBP [mm Hg] & 140 (137.5; 154) & 125 (106; 132) & \textless{}0.001 \\ \hline DBP [mm Hg] & 90 (80; 100) & 80 (75; 91) & \textless{}0.001 \\ \hline Adipolin [ng/mL] & 0.60 (0.14; 1.33) & 1.08 (0.13; 3.29) & 0.354 \\ \hline Neprilysin [pg/mL] & 810.63 (736.56; 1131.56) & 785.94 (637.81; 1304.38) & 0.736 \\ \hline Chemerin [ng/mL] & 47.71 (35.50; 68.48) & 44.59 (28.33; 74.20) & 0.853 \\ \hline \end{tabular}
\begin{tabular}{l c c} \hline  & **A. Adipolin concentration [ng/mL]** \\ \hline  
In the analyzed groups, there were no statistically significant differences in the concentrations of adipolin, chemerin, and neprilysin when gender was considered. Detailed information is included in the supplement (Tables S1-S16).  
Figure 1: Adipokine concentrations ((**A**)—adipolin, (**B**)—chemerin, (**C**)—neprilysin) in NGT (normal glucose tolerance) group (\(n=24\); assigned as light boxes) and AGT (abnormal glucose tolerance) group (\(n=27\); assigned as grey boxes); \(n\)—number of subjects.  
The chi-square test conducted in the obesity group divided into two groups (with CRP above 5 ng/mL and below this value) indicated no statistically significant differences in frequency of elevated glycemia in 120\({}^{\prime}\) OGTT (above vs. below 7.8 mmol/L), elevated insulinemia (above vs. below 12 uU/L), elevated triglyceridesion (above vs. below 1.7 mmol/L), elevated blood pressure (above 130 mmHg for SBP and/or above 85 mmHg for DBP vs. below), reduced HDL cholesterol (below vs. above 1.0 mmol/L in male group and 1.3 mmol/L in the female group), (Table 3).