## 3 Experimental
### Chemistry
#### 3.1.2. Synthesis of Bipyridine Derivatives **8** and **9**
for C\({}_{38}\)H\({}_{32}\)N\({}_{6}\)O\({}_{3}\) (620.71): C, 73.53; H, 5.20; N, 13.54. Found: C, 73.39; H, 5.38; N, 13.36%. _Ethly 3-(3-acetyl-1-(4-chlorophenylenyl)-5-phenyl-1,5-dihydro-[1,2,4]triazoleolo[4,3-\(a\)]pyrimidine-7-yl)-1,5-diphenyl-1H-pyrazol-4-carboxylate_**(15c)**. Yellow solid, (74% yield), mp 242-244 \({}^{\circ}\)(DMF/EtOH); IR (KBr) \(\
u_{\rm max}\) 3028, 2963 (C-H), 1707, 1641 (2C=O), 1597 (C=N) cm\({}^{-1}\); \({}^{1}\)H NMR (DMSO-\(d_{6}\)) 8 1.02 (t, J = 7.2 Hz, 3H, CH\({}_{3}\)), 2.44 (s, 3H, CH\({}_{3}\)), 4.15 (q, J = 7.2 Hz, 2H, CH\({}_{2}\)), 5.36 (d, J = 4 Hz, 1H, CH), 6.69 (d, J = 4 Hz, 1H, CH), 7.27-7.70 (m, 19H, Ar-H); MS \(m/z\) (%) 643 (M\({}^{+}\), 2), 4), 641 (M\({}^{+}\), 13), 499 (57), 322 (39), 180 (28), 105 (35), 77 (100). Anal. Calcd. for C\({}_{37}\)H\({}_{29}\)ClN\({}_{6}\)O\({}_{3}\) (641.13): C, 69.32; H, 4.56; N, 13.11. Found: C, 69.19; H, 4.51; N, 13.00%. _Ethly 3-(3-acetyl-1-(4-nitrophenyl)-5-phenyl-1,5-dihydro-[1,2,4]triazoleolo[4,3-\(a\)]pyrimidine-7-yl)-1,5-diphenyl-1H-pyrazol-4-carboxylate_**(15d)**. Yellow solid, (75% yield), mp 204-206 \({}^{\circ}\)(EtOH); IR (KBr) \(\(C-H), 1712, 1656 (2C=O), 1598 (C=N) cm\({}^{-1}\); \({}^{1}\)H NMR (DMSO-\(d_{6}\)) 8 1.02 (t, \(J\) = 7.2 Hz, 3H, CH\({}_{3}\)), 2.47 (s, 3H, CH\({}_{3}\)), 4.15 (q, \(J\) = 7.2 Hz, 2H, CH\({}_{2}\)), 5.39 (d, \(J\) = 4 Hz, 1H, CH), 6.72 (d, \(J\) = 4 Hz, 1H, CH), 7.24-8.52 (m, 19H, Ar-H); MS \(m/z\) (%) 651 (M\({}^{+}\), 26), 484 (48), 400 (71), 252 (39), 179 (42), 105 (100), 57 (83). Anal. Calcd. for C\({}_{37}\)H\({}_{29}\)N\({}_{7}\)O\({}_{5}\) (651.68): C, 68.19; H, 4.49; N, 15.05. Found: C, 68.04; H, 4.33; N, 14.92%. _Ethly 7-(4-(ethoxycarbonyl)-1,5-diphenyl-1H-pyrazol-3-yl)-1,5-diphenyl-1,5-dihydro-[1,2,4]triazole0[4,3-a] pyrimidine-3-carboxylate_ (**15c**). Yellow solid, (72% yield), mp 180-182 \({}^{\circ}\)C (DMF/ EtOH); IR (KBr) \(\gamma_{\max}\) 3056, 2973 (C-H), 1713, 1679 (2C=O), 1596 (C=N) cm\({}^{-1}\); \({}^{1}\)H NMR (DMSO-\(d_{6}\)) 8 1.04 (t, \(J\) = 7.2 Hz, 3H, CH\({}_{3}\)), 1.26 (t, \(J\) = 7.6 Hz, 3H, CH\({}_{3}\)), 4.14 (q, \(J\) = 7.2 Hz, CH\({}_{2}\)), 4.26 (q, \(J\) = 7.6 Hz, 2H, CH\({}_{2}\)), 5.46 (d, \(J\) = 4 Hz, 1H, CH), 6.47 (d, \(J\) = 4 Hz, 1H, CH), 6.96-7.79 (m, 20H, Ar-H); MS \(m/z\) (%) 636 (M\({}^{+}\), 9), 394 (51), 283 (33), 235 (49), 194 (62), 83 (53), 57 (100). Anal. Calcd. for C\({}_{38}\)H\({}_{32}\)N\({}_{6}\)O\({}_{4}\) (636.71): C, 71.68; H, 5.07; N, 13.20. Found: C, 71.62; H, 5.01; N, 13.03%. _Ethly 7-(4-(ethoxycarbonyl)-1,5-diphenyl-1H-pyrazol-3-yl)-5-phenyl-1-(p-tolyl)-1,5-dihydro-[1,2,4]triazole0 [4,3-a]pyrimidine-3-carboxylate_ (**15f**). Yellow solid, (73% yield), mp 172-174 \({}^{\circ}\)C (EtOH); IR (KBr) \(\gamma_{\max}\) 3052, 2955 (C-H), 1710, 1699 (2C=O), 1595 (C=N) cm\({}^{-1}\); \({}^{1}\)H NMR (DMSO-\(d_{6}\)) 8 1.02 (t, \(J\) = 7.2 Hz, 3H, CH\({}_{3}\)), 1.23 (t, \(J\) = 7.6 Hz, 3H, CH\({}_{3}\)), 2.30 (s, 3H, CH\({}_{3}\)), 4.10 (q, \(J\) = 7.2 Hz, 2H, CH\({}_{2}\)), 4.26 (q, \(J\) = 7.6 Hz, 2H, CH\({}_{2}\)), 5.39 (d, \(J\) = 4 Hz, 1H, CH), 6.45 (d, \(J\) = 4 Hz, 1H, CH), 7.12-7.76 (m, 19H, Ar-H); MS \(m/z\) (%) 650 (M\({}^{+}\), 6), 439 (44), 361 (30), 244 (57), 104 (100), 91 (48), 43 (60). Anal. Calcd. for C\({}_{39}\)H\({}_{34}\)N\({}_{6}\)O\({}_{4}\) (650.74): C, 71.98; H, 5.27; N, 12.91. Found: C, 71.75; H, 5.19; N, 12.74%. _Ethly 1-(4-chlorophenylophenyl)-7-(4-(ethoxycarbonyl)-1,5-diphenyl-1H-pyrazol-3-yl)-5-phenyl-1,5-dihydro-[1,2,4] triazol0[4,3-a]pyrimidine-3-carboxylate_ (**15g**).