## 3 Results
### Neuropsychological Test Scores Analysis
\begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Carrier Status** & \begin{tabular}{c} **APOE \(\epsilon\)4\(-\)** \\ **(n = 85)** \\ \end{tabular} & \
\begin{tabular}{c} **APOE \(\epsilon\)4\(+\)** \\ **(n = 24)** \\ \end{tabular} &
\begin{tabular}{c} **B-Value** \\ **B-Value** \\ \end{tabular} & **95\% CI** & \(p\)**-Value** \\ \hline LM Delay & 11.3 & 12.8 & \(-\)1.447 & \(-\)3.524 to 0.631 & 0.172 \\ \hline LM Recognition & 12 & 12.2 & \(-\)0.22 & \(-\)1.009 to 0.570 & 0.586 \\ \hline CVLT\_TL & 41.3 & 45 & \(-\)3.547 & \(-\)8.980 to 1.886 & 0.201 \\ \hline CVLT sdfr & 8.8 & 9.6 & \(-\)0.585 & \(-\)2.282 to 1.112 & 0.499 \\ \hline CVLT ldr & 9.3 & 9.8 & \(-\)0.273 & \(-\)2.101 to 1.554 & 0.769 \\ \hline Letter Fluency & 42.2 & 44.4 & \(-\)1.817 & \(-\)6.948 to 3.314 & 0.488 \\ \hline Category Fluency & 19.7 & 19.5 & 0.147 & \(-\)1.679 to 1.972 & 0.875 \\ \hline SDMT & 48.5 & 48.9 & \(-\)0.283 & \(-\)4.653 to 4.087 & 0.899 \\ \hline DSF & 11 & 10.9 & 0.169 & \(-\)0.847 to 1.185 & 0.744 \\ \hline DSB & 9.2 & 8.4 & 0.905 & \(-\)0.038 to 1.848 & 0.06 \\ \hline DS Seq & 8 & 8.4 & \(-\)0.348 & \(-\)1.055 to 0.358 & 0.334 \\ \hline DS Total & 28.2 & 27.6 & 0.726 & \(-\)1.265 to 2.717 & 0.475 \\ \hline TMA & 32.6 & 33.4 & \(-\)0.277 & \(-\)4.030 to 3.476 & 0.885 \\ \hline TMB & 79 & 92.7 & \(-\)11.14 & \(-\)34.891 to 12.610 & 0.358 \\ \hline BNT\_NCS & 27.4 & 27.7 & \(-\)0.414 & \(-\)1.468 to 0.640 & 0.441 \\ \hline MMSE & 28.4 & 28.7 & \(-\)0.363 & \(-\)1.099 to 0.372 & 0.333 \\ \hline GDS & 1.9 & 1.4 & 0.504 & \(-\)1.062 to 0.923 & 0.288 \\ \hline RCFT\_1 & 33.7 & 34.2 & \(-\)0.619 & \(-\)1.962 to 0.723 & 0.366 \\ \hline RCFT\_2 & 17.3 & 19.2 & \(-\)1.97 & \(-\)5.351 to 1.411 & 0.253 \\ \hline RCFT\_3 & 16.6 & 17.5 & \(-\)0.813 & \(-\)4.600 to 2.973 & 0.674 \\ \hline \multicolumn{6}{c}{Visual Evoked Potential} \\ \hline VEP Amplitude (nV) & 141 & 154.1 & \(-\)5.601 & \(-\)29.539 to 18.337 & 0.647 \\ \hline VEP Latency (ms) & 143.6 & 139.4 & 4.241 & \(-\)2.981 to 11.462 & 0.25 \\ \hline \multicolumn{6}{c}{MRI Brain Volumes (mL)} \\ \hline ETICV & 1,567,758 & 1,548,422 & \(-\)39,335.344 & \(-\)112,315,810 to 33,645.121 & 0.291 \\ \hline TGMV & 600,412 & 597,664 & \(-\)14,160.752 & \(-\)40,569.022 to 12,247.518 & 0.293 \\ \hline Cortex Volume & 438,318 & 437,714 & \(-\)12,689.852 & \(-\)34,193.327 to 8813.623 & 0.247 \\ \hline CWMV & 447,808 & 444,803 & \(-\)5479.851 & \(-\)20,893.032 to 9933.330 & 0.486 \\ \hline GM Cingulate & 18,396 & 17,873 & \(-\)180.946 & \(-\)1182.660 to 820.768 & 0.723 \\ \hline GM Parietal & 102,065 & 100,950 & \(-\)1798.391 & \(-\)7333.500 to 3736.717 & 0.524 \\ \hline Entorhinal Volume & 3798 & 3840 & \(-\)132.203 & \(-\)472.440 to 208.034 & 0.446 \\ \hline Third Ventricle & 1534 & 1552 & \(-\)148.685 & \(-\)400.656 to 103.286 & 0.247 \\ \hline Forth Ventricle & 1970 & 1796 & 116.368 & \(-\)68.410 to 301.146 & 0.217 \\ \hline Thalamus & 13,368 & 13,225 & \(-\)127.904 & \(-\)810.665 to 554.857 & 0.713 \\ \hline Putamen & 9110 & 8935 & 3.211 & \(-\)748.604 to 755.026 & 0.993 \\ \hline Hippocampus & 7962 & 7795 & 69.839 & \(-\)333.016 to 472.694 & 0.734 \\ \hline \hline \end{tabular} Abbreviations: RNFL = retinal nerve fibre layer; mfVEP = multifocal visual evoked potential; Amp = amplitude; Lat = latency; nV = nanovolvs; ms = milliseconds; GM = grey matter; LM = logical memory; CVLT = California Verbal Learning Test; TL = total learning; sdfr = short-delay free recall; ldfr = long-delay free recall; ldfr = 8 symbolsoffr Leg = Symbol Digit Modality Test; DS = digit span; TMT = rrail-Making Test; BNT_NCS = Boston Naming Test—no-cue score; RCFT = Rey Complex Figure Test; MMSE = Mini-Mental State Examination; GDS = Geriatric Depression Scale. ETICV = estimated total intracranial volume; TGMV = total grey matter volume; CWMV = cerebral white matter volume. *\(p\) + 0.05.  
\end{table} 
Table 3: _Cont_.