## 3 Results
### Effects of Honey Extract on Blood Glucose Level (BGLs (mg/dL) and Liver Glycogen (mg/gm Tissue)  
The results obtained in Table 2 demonstrated that the diabetic group III exhibited significantly higher BGLs. However, BGLs in the treated group IV and V were much lower (132 \(\pm\) 6.45, 149 \(\pm\) 4.63 mg/dL), respectively, than those in group III (233 \(\pm\) 6.72 mg/dL). Furthermore, the liver glycogen content significantly dropped in the diabetic group III (4.6 \(\pm\) 0.18 mg/gm tissue) compared to that of group I (7.13 \(\pm\) 0.16 mg/gm tissue). Nevertheless, treatment with insulin and honey extract in group IV and V significantly restored declined glycogen content to (7.06 \(\pm\) 0.29, 6.86 \(\pm\) 0.13 mg/gm tissue), respectively, compared to diabetic group III and showed insignificant changes in comparison with groups I and II. Effects of Honey Extract on SOD (unit/min/mg Protein), Reduced GSH (\(\mu\)mol/gm Wet Tissue) and CAT (\(\mu\)mol/gm Wet Tissue) Activity of Pancreatic Tissue  
The activity of SOD, GSH, and CAT in the diabetic group III was significantly reduced compared with the normal group I. Treatment with insulin and honey extract group IV and V revealed a significant amelioration of SOD, GSH and CAT activity compared with diabetic group III. This amelioration of GSH activity was high enough to achieve insignificant changes compared to that in group I, while CAT and SOD enzyme activity were still considerably lower (Table 3). \begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Groups** & **Group I Normal** & \begin{tabular}{c} **Group II** \\ **Control** \\ \end{tabular} & \begin{tabular}{c} **Group III** \\ **Normal and** \\ **Extract Treated** \\ \end{tabular} & \begin{tabular}{c} **Group IV** \\ **Diabetic and** \\ **Diabetic and** \\ **Insulin Treated** \\ \end{tabular} & \begin{tabular}{c} **Group V** \\ **Diabetic and** \\ **Extract Treated** \\ \end{tabular} \\ \hline \begin{tabular}{c} Initial Weight (gm) \\ Day 1 \\ \end{tabular} & 24.1 \(\pm\) 0.54 & 24.3 \(\pm\) 0.34 & 24.8 \(\pm\) 0.55 & 24.2 \(\pm\) 0.42 & 24.6 \(\pm\) 0.52 \\ \hline \
\begin{tabular}{c} 7 days after STZ \\ injection (gm) Day 22 \\ \end{tabular} & 25.7 \(\pm\) 0.56 & 24.9 \(\pm\) 0.21 & 19.9 \(\pm\) 0.46 \({}^{\text{ab}}\) & 18.7 \(\pm\) 0.96 \({}^{\text{ab}}\) & 19.6 \(\pm\) 0.43 \({}^{\text{ab}}\) \\ \hline
\begin{tabular}{c} Weight after 24 days of \\ treatment (gm) Day 46 \\ \end{tabular} & 26.4 \(\pm\) 0.55 & 26.2 \(\pm\) 0.19 & 17.6 \(\pm\) 0.42 \({}^{\text{ab}}\) & 23.4 \(\pm\) 0.57 \({}^{\text{abc}}\) & 22.8 \(\pm\) 0.48 \({}^{\text{abc}}\) \\ \hline \hline \end{tabular}  
* Data expressed as mean \(\pm\) SEM. \({}^{\text{a}}\) significant vs. normal control, \({}^{\text{b}}\) significant vs. normal with extract treated, \({}^{\text{c}}\) significant vs. diabetic group. (ANOVA with Tukey HSD post-hoc Test).  
\end{table} 
Table 1: Effect of honey extract 2 mg/kg/b.wt on mice body weight. \begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Groups** & **Group I Normal** & \begin{tabular}{c} **Group II** \\ **Control** \\ \end{tabular} & \begin{tabular}{c} **Group III** \\ **Normal and** \\ **Extract Treated** \\ \end{tabular} & \
\begin{tabular}{c} **Group IV** \\ **Diabetic and** \\ **Disuline Treated** \\ \end{tabular} &
\begin{tabular}{c} **Group V** \\ **Diabetic and** \\ **Extract Treated** \\ \end{tabular} \\ \hline Glucose mg/dL & 94 \(\pm\) 3.42 & 96 \(\pm\) 5.27 & 233 \(\pm\) 6.72 \({}^{\text{ab}}\) & 132 \(\pm\) 6.45 \({}^{\text{abc}}\) & 149 \(\pm\) 4.63 \({}^{\text{abc}}\) \\ \hline Glycogen mg/gm tissue & 7.13 \(\pm\) 0.16 & 6.92 \(\pm\) 0.11 & 4.6 \(\pm\) 0.18 \({}^{\text{ab}}\) & 7.06 \(\pm\) 0.29 \({}^{\text{c}}\) & 6.86 \(\pm\) 0.13 \({}^{\text{c}}\) \\ \hline \hline \end{tabular}  
* Data expressed as mean \(\pm\) SEM. \({}^{\text{a}}\) significant vs. normal control, \({}^{\text{b}}\) significant vs. normal with extract treated, \({}^{\text{c}}\) significant vs. diabetic group. (ANOVA with Tukey HSD post-hoc Test).  
\end{table}