## 2 Materials and Methods
### Chemistry
{2-[4-(_tert_-Butyl)phenyl][ethyl]quinazolin-4-ylamine, **12a**  
Following general procedure A, using 4-chloroquinazoline (**5**, 100 mg, 0.59 mmol), 2-[4-(tert-butyl)phenyl]ethylamine (110 mg, 0.59 mmol) and potassium carbonate (81 mg, 0.59 mmol) gave **12a** as yellow crystals (58 mg, 29%). mp 149.5-151.3 \({}^{\circ}\)C; \({}^{1}\)H (500 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 8.71 (s, 1H), 7.86 (dd, \(J\) = 8.4, 0.6 Hz, 1H), 7.74 (ddd, \(J\) = 8.4, 7.0, 1.3 Hz, 1H), 7.57 (ddd, \(J\) = 8.3, 0.8 Hz, 1H), 7.45 (ddd, \(J\) = 8.2, 7.0, 1.2 Hz, 1H), 7.39 (dt, \(J\) = 8.3, 2.3 Hz, 2H), 7.22 (dt, \(J\) = 8.3, 2.2 Hz, 2H), 5.81 (brs, 1H), 3.96 (dt, \(J\) = 6.8, 5.7 Hz, 2H), 3.04 (t, \(J\) = 6.8 Hz, 2H), 1.35 (s, 3H). \({}^{13}\)C (125 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 159.3, 155.5, 149.6, 149.5, 135.8, 132.5, 128.7, 128.5, 125.9, 125.7, 120.3, 115.0, 42.3, 34.7, 34.5, 31.4. HRMS (EI), M + 1 calculated for C\({}_{20}\)H\({}_{23}\)N\({}_{3}\), 306.1965, found 306.1967. These experimental results are consistent with a previous report [21]. Quinazolin-4-yl[2-(3-(trifluoromethylomenthoxy)phenyl]ethyl]amine, **13a**  
Following general procedure A, using 4-chloroquinazoline (**5**, 100 mg, 0.59 mmol), 3-(trifluoromethyloxy)phenylamine (125 mg, 0.59 mmol) and potassium carbonate (84 mg, 0.59 mmol) gave **13a** as white crystals (136 mg, 67%). mp 144.0-144.9 \({}^{\circ}\)C; \({}^{1}\)H (500 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 8.72 (s, 1H), 7.87 (d, \(J\) = 7.8 Hz), 7.76 (ddd, \(J\) = 8.4, 7.0, 1.3 Hz, 1H), 7.60 (ddd, \(J\) = 8.2, 7.0, 1.2 Hz, 1H), 7.39-7.35 (m, 1H), 7.22-7.19 (m, 1H), 7.16-7.12 (m, 1H), 5.83 (brs, 1H), 3.97 (dt, \(J\) = 6.9, 5.9 Hz, 2H), 3.09 (t, \(J\) = 6.9 Hz, 2H). \({}^{13}\)C (125 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 159.3, 155.4, 149.5 (q, \(J\) = 1.8 Hz), 141.3, 132.6, 130.1, 128.7, 127.3, 126.1, 121.4, 120.5 (q, \(J\) = 257.2 Hz), 120.2, 119.1, 114.9, 42.1, 35.1. \({}^{19}\)F (470 MHz, CDCl\({}_{3}\)) \(\delta\) ppm -57.7 (s, 3F). HRMS (EI), M + 1 calculated for C\({}_{17}\)H\({}_{14}\)F\({}_{3}\)N\({}_{3}\)O, 306.1965, found 306.1967. [2-(3-Ethoxypheny)ethyl]quinazolin-4-ylamine, **14a**  
Following general procedure A, using 4-chloroquinazoline (**5**, 151 mg, 0.92 mmol), 3-ethoxyphenyethylamine (155 mg, 0.92 mmol) and potassium carbonate (127 mg\(J\) = 8.0 Hz, 1H), 7.44 (ddd, \(J\) = 8.0, 7.0, 1.1 Hz, 1H), 6.86 (d, \(J\) = 7.5 Hz, 1H), 6.83-6.79 (m, 2H), 5.79 (br.s, 1H), 4.02 (q, \(J\) = 7.0 Hz, 2H), 3.96 (dt, \(J\) = 6.7, 5.8 Hz, 2H), 1.42 (t, \(J\) = 7.0 Hz, 3H), 13C (125 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 159.4, 159.3, 155.5, 149.5, 140.4, 132.5, 129.8, 128.7, 126.0, 121.0, 120.3, 115.1, 115.0, 112.6, 63.4, 42.1, 35.3, 14.8. HRMS (EI), M + 1 calculated for C\({}_{18}\)H\({}_{19}\)N\({}_{3}\)O, 294.1601, found 294.1616. Quinazolin-4-yl[2-[2-(trifluoromethylomethyl)phenylylethyl]amine, **15a**  
Following general procedure A outlined, using 4-chloroquinazoline (**5**, 100 mg, 0.59 mmol), 2-(2-trifluoromethylphenyl)ethylamine (117 mg, 0.59 mmol) and potassium carbonate (81 mg, 0.59 mmol) gave **15a** as a yellow flaky solid (68 mg, 34%). mp 134.4-137.4 \({}^{\circ}\)C; \({}^{1}\)H (500 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 8.64 (s, 1H), 8.12-8.05 (m, 1H), 7.95 (d, \(J\) = 8.3 Hz, 1H), 7.80-7.74 (m, 1H), 7.66 (d, \(J\) = 7.8 Hz, 1H), 7.54-7.49 (m, 1H), 7.49-7.46 (m, 1H), 7.37-7.32 (m, 1H), 4.04 (dt, \(J\) = 6.9, 6.7 Hz, 2H), 3.30 (t, \(J\) = 7.2 Hz, 2H). \({}^{13}\)C (125 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 159.9, 153.5, 145.7, 137.3, 133.6, 132.0, 131.7, 128.9 (q, \(J\) = 29.7 Hz), 126.9, 126.1 (q, \(J\) = 5.7 Hz), 126.8, 125.7, 124.5 (q, \(J\) = 254.0 Hz), 121.9, 114.4, 42.7, 31.8. \({}^{19}\)F (470 MHz, CDCl\({}_{3}\)) \(\delta\) ppm \(-\)59.2 (s, 3F). HRMS (EI), M + 1 calculated for C\({}_{17}\)H\({}_{14}\)F\({}_{3}\)N\({}_{3}\)O\({}_{2}\), 364.1267, found 364.1276.