## 2 Materials and Methods
### Search Strategy  
To ensure a comprehensive search for relevant studies, a targeted search string was developed based on the project's focus areas, starting from keywords identified through an initial set of relevant papers, and validated via a series of focus groups with biomedical engineers and medical doctors with substantive expertise in evidence generation in medicine. Moreover, PUBMED mesh term finder was used to look for possible synonym key terms to ensure a complete search string. The identified key terms were combined using Boolean operators (e.g., AND, OR) and the final search string was obtained.  
The Scopus search string was TITLE-ABS-KEY((\"eye track\" OR \"gaze track\" OR \"ocular track\" OR \"eye mov\" OR \"gaze detection\" OR \"eye gaze\" OR \"pupil track\") AND (\"machine learning\" OR \"ML\" OR \"artificial intelligence\" OR \"AI\" OR \"deep learning\" OR \"computer vision\" OR \"neural networks\" OR \"CNN\" OR \"pattern recognition\" OR \"computational model\" OR \"natural language processing\" OR \"NLP\" OR \"text comprehension\" OR \"image classification\") AND (\"blink\" OR \"fixation\" OR \"saccad\" OR \"pupil dilat\" OR \"pupil constric\" OR \"eye strain\" OR \"visual fatigue\" OR \"ocular fatigue\" OR \"cognitive load\" OR \"attention span\" OR \"digital fatigue\" OR \"screen time\" OR \"screen exposure\" OR \"reading fatigue\" OR \"focus loss\" OR \"biomedical\" OR \"visual attention\" OR \"Computer Vision Syndrome\" OR \"CVS\" OR \"asthenopia\" OR \"bloodshot eye\" OR \"eye redness\") AND (\"productivity\" OR \"efficiency\" OR \"work performance\" OR \"focus enhancement\" OR \"reading comprehension\" OR \"reading skill\" OR \"reading performance\" OR \"cognitive function\" OR \"visual engagement\" OR \"task engagement\" OR \"productivity software\" OR \"performance optimi?ation\" OR \"fatigue management\" OR \"break suggestion\" OR \"cognitive engagement\" OR \"reading focus\" OR \"personali?ed feedback\" OR \"behavior?ar analysis\" OR \"text highlight\" OR \"word highlight\" OR \"bionic reading\" OR \"memory\" OR \"medical imaging\").  
The Web Of Sciences search string was (\"eye track\" OR \"gaze track\" OR \"ocular track\" OR \"eye mov\" OR \"gaze detection\" OR \"eye gaze\" OR \"pupil track\") AND (\"machine learning\" OR \"ML\" OR \"artificial intelligence\" OR \"AI\" OR \"deep learning\" OR \"computer vision\" OR \"neural networks\" OR \"CNN\" OR \"pattern recognition\" OR \"computational model\" OR \"natural language processing\" OR \"NLP\" OR \"text comprehension\" OR \"image classification\") AND (\"blink\" OR \"fixation\" OR \"saccad\" OR \"pupil dilat\" OR \"pupil constric\" OR \"eye strain\" OR \"visual fatigue\" OR \"ocular fatigue\" OR \"cognitive load\" OR \"attention span\" OR \"digital fatigue\" OR \"screen time\" OR \"screen exposure\" OR \"reading fatigue\" OR \"focus loss\" OR \"biomedical\" OR \"visual attention\" OR \"Computer Vision Syndrome\" OR \"CVS\" OR \"asthenopia\" OR \"bloodspot eye\" OR \"eye redness\") AND (\"productivity\" OR \"efficiency\" OR \"work performance\" OR \"focus enhancement\" OR \"reading comprehension\" OR \"reading skill\" OR \"reading performance\" OR \"cognitive function\" OR \"visual engagement\" OR \"task engagement\" OR \"productivity software\" OR \"performance optimi?ation\" OR \"fatigue management\" OR \"break suggestion\" OR \"cognitive engagement\" OR \"reading focus\" OR \"personali?ed feedback\" OR \"behavior?ar analysis\" OR \"text highlight\" OR \"footing  
The search was conducted on the Scopus and Web of Sciences databases. This initial search produced 1782 articles (1024 and 758, respectively). These were then filtered to remove duplicates and include only publications in English and within the period from January 2015 to November 2024, i.e., the last 10 years, to consider only recent advancements in technology, reducing the set to 924 articles.