###### Abstract
Although PMS systems provide several advantages, such as portability, ease of use, and minimal sample preparation, they also have certain limitations, including lower resolution and sensitivity compared to benchtop instruments, which arise from their compact design and simplified vacuum systems. Nevertheless, recent advances in PDESI-based PMS configurations have improved their performance for multi-analyte detection in complex matrices, making them increasingly valuable for real-time food safety monitoring in field settings [21; 22]. Several alternative techniques can reduce or eliminate the need for extensive sample preparation. These include flow injection analysis, ambient mass spectrometry, and continuous phase membrane introduction mass spectrometry [23]. However, sample pretreatment is still critical to minimize matrix interference before PMS detection, especially in complex food samples containing veterinary drugs. Common techniques include liquid-liquid extraction, dispersive liquid-liquid microextraction, dispersive solid-liquid phase extraction, stir bar sorptive extraction, and solid-phase microextraction (SPME) [24]. SPME is particularly advantageous, as it integrates sampling, separation, enrichment, and injection into a single streamlined process [25]. Conventional SPME fiber utilizes a thin fused silica or stainless-steel wire as the substrate that coated with a layer of adsorbent or absorbent. However, the SPME fiber's small surface area limits its extraction capacity, and its mechanical fragility can reduce its lifespan, especially during repeated sampling. In contrast, the SPME Arrow--introduced in 2015--addresses these limitations by featuring a larger diameter and more robust construction, offering several key advantages over traditional SPME fibers [26]. The SPME Arrow has a 10-fold larger coating volume, which significantly enhances extraction efficiency, especially for trace-level analytes. Additionally, the increased mechanical strength of the Arrow reduces the risk of fiber breakage and improves the stability of the coating, allowing for repeated use without performance degradation [27]. These structural modifications result in higher sensitivity, improved robustness, and greater reproducibility in complex matrices. However, the efficiency of the SPME Arrow depends heavily on the adsorbent material. Mesoporous silica materials (MSM) [28] and metal-organic frameworks (MOFs) have been widely used for sample preparation [29]. MSMs offer high porosity, ordered pore channels, stability, and various functionalization options. SBA-15, SBA-16, and MCM-41 are typical MSMs with distinguished pore structures and pore sizes [27; 30; 31]. SBA-15 and MCM-41 exhibited two-dimensional pore structures with different pore sizes. SBA-16 exhibited a similar pore size to MCM-41 but with a three-dimensional pore structure. MOFs, with their highly porous structure composed of metal ions and organic linkers, are ideal for applications such as gas storage and separation [29]. Zirconium-based MOFs have gained wide attention because of their high physical and chemical stability and tunable pore size [32]. Representative Zirconium-based MOFs are UiO-66 and amino- UiO-66 ( UiO-66-NH\({}_{2}\)), which have ordered two-dimensional pore structures and microporous pore sizes. Furthermore, mesoporous UiO-66 series materials are also available after a post-synthesis modification step [26]. Therefore, both MSMs and MOFs have great potential to adsorb various analytes. Therefore, a comprehensive comparison of these materials is essential for optimizing adsorption performance across a wide range of analytes. This study presents a novel approach to detecting veterinary drugs in food products by integrating PMS with the SPME Arrow. Specifically, five veterinary drugs--amantadine, thiabendazole, sulfamethazine, clenbuterol, and ratcopamine--were used as the template analytes, and milk and chicken were chosen as the template food samples.