## 4 Discussion
\begin{table}
\begin{tabular}{c c c c c c c c c c c c c c c} \hline \hline
**Auto, Year** & **Q1** & **Q2** & **Q3** & **Q4** & **Q5** & **Q6** & **Q7** & **Q8** & **Q9** & **Q10** & **Q11** & **Q22** & **Q13** & \begin{tabular}{c} **Overall** \\ **Appraisal** \\ \end{tabular} \\ \hline \begin{tabular}{c} [PERSON] et al., \\ 2017 [23] \\ \end{tabular} & Y & Y & Y & Y & N & Y & Y & Y & Y & Y & Y & Y & Y & Induce \\ \hline \begin{tabular}{c} [PERSON] et al., \\ 2021 [24] \\ \end{tabular} & Y & Y & Y & U & U & U & Y & Y & Y & Y & Y & Y & Y & Induce \\ \hline \begin{tabular}{c} [PERSON] \\ et al., 2019 [25] \\ \end{tabular} & Y & Y & Y & Y & Y & N & Y & Y & Y & Y & Y & Y & Y & Induce \\ \hline \begin{tabular}{c} [PERSON] et al., \\ 2020 [26] \\ \end{tabular} & N & N & Y & U & U & U & Y & Y & Y & Y & Y & Y & Y & Induce \\ \hline \begin{tabular}{c} [PERSON] \\ et al., 2014 [27] \\ \end{tabular} & Y & Y & Y & U & U & U & Y & Y & Y & Y & Y & Y & Induce \\ \hline \begin{tabular}{c} [PERSON] et al., \\ 2017 [28] \\ \end{tabular} & Y & Y & Y & Y & Y & N & Y & Y & Y & Y & Y & Y & Y & Induce \\ \hline \begin{tabular}{c} [PERSON] \\ et al., 2022 [29] \\ \end{tabular} & Y & Y & Y & U & U & U & Y & Y & Y & Y & Y & Y & Y & Induce \\ \hline \
\begin{tabular}{c} [PERSON] et al., \\ 2016 [30] \\ \end{tabular} & N & N & Y & U & U & U & Y & Y & Y & Y & Y & Y & Induce \\ \hline
\begin{tabular}{c} [PERSON] et al., \\ 2006 [31] \\ \end{tabular} & U & U & Y & Y & N & Y & Y & Y & Y & Y & Y & Y & Induce \\ \hline \hline \end{tabular}
\end{table} 
Table 2: _Cont._and photobiomodulation therapy (PBMT) also aid in axonal regeneration and functional recovery. PBMT, utilizing low-level infrared light, stimulates SC proliferation and axonal diameter expansion, yet standardized application parameters remain a challenge [25]. Subsequently, in 1992, [PERSON] and [PERSON] [26] demonstrated that photobiomodulation therapy (PBMT) influenced the electrical activity and morphology of injured and intact peripheral nerves in rats. They observed that the action potential of intact nerves increased by up to 33% following a single transcutaneous laser treatment. Similarly, injured nerves subjected to corresponding therapy exhibited a significantly increased action potential amplitude compared to untreated injured nerves [26]. [PERSON] and colleagues [27] conducted an investigation using a rat model to assess the effectiveness of PBMT on nerve regeneration. Their findings revealed that in studies involving highly metabolically active cells like nerve tissue, unfavorable outcomes were more commonly attributed to excessive dosing rather than insufficient dosing. In the current research, a notably expedited nerve recovery was achieved using an energy density of 6 J/cm\({}^{2}\). This discovery lends support to the notion of a \"biphase dose-response\" phenomenon in PBMT, wherein positive biostimulation responses are triggered at doses below 10 J/cm\({}^{2}\), while inhibitory responses are prominent at doses surpassing 20 J/cm\({}^{2}\)[27]. Nevertheless, this concept of a \"window effect\" has been extensively examined in existing literature, and the findings from the study under consideration align well with the established data in this field. The results obtained from the immunoblotting analysis conducted on the second day after the injury indicated elevated concentrations of the nerve growth factor (NGF) in rats that underwent PBMT treatment, in comparison to the control group that did not receive PBMT. This rise in NGF levels corresponded with a swifter restoration of neurossensory functionality [26]. Likewise, a multitude of other investigations, encompassing both controlled and uncontrolled trials, have highlighted favorable subjective enhancements attributed to PBMT across diverse clinical contexts, such as period lesions [26], recovery after musculoskeletal surgery [24], and the promotion of osteogenic differentiation [27]. To sum up, PBMT manifests positive influences on distinct nervous, musculoskeletal, and epithelial systems.