## 1 Introduction  
Glycolipids and, more generally, surfactants are getting more attention and are currently under scrutiny from the scientific community because of their various fields of applications [1]. This versatility allows them to fill different functions, such as excipient in drugs, encapsulating agents, lubricants and many more [2]. Such quasi-omnipresence makes their use valuable in very concrete and industrialized applications such as oil recovery enhancement or even as dough conditioning [3, 4]. Moreover, the recent sanitary crisis, which resulted from the current global pandemic, is announced to increase further this production, as surfactants are among the main components present in hygiene products [5]. Thus, the whole chain of production starting from the acquisition of raw materials to the formulation and storage should be logically stimulated as well. Given the context, it appears topical to develop processes that enable safe, reliable and straightforward production of such compounds. In addition, the processes and the resulting compounds should respond to present concerns in relation to sustainability, renewability, and biodegradability. Such problems brought to awareness and theorized by the Green Chemistry field revolve around the \"benign by design\" concept [6]. By definition, it means that chemical products and processes should be designed to eliminate the generation of hazardous substances [7]. Therefore, it reduces the number of steps necessary for the production, from the synthesis to the downstream processing (DSP), and simplifies the overall process chain. Glycolipids, such as sugar esters (SEs), are, in this regard, relevant candidates that meet the aforementioned requirements; several challenges and problems are raising in the meantime, which are tackled in this work. The well-established chemical production of SEs presents several disadvantages and limitations such as low specificity, low selectivity and use of corrosive reactants [8]. Consequently, alternative ways were pursued to prevent the use of organic solvents, as they represent most of the waste in industrial processes and syntheses [9]. Moreover, they present undeniable limitations for the solubilization of polyols such as sugars. In this aim, the production of SEs in ionic liquids (ILs) [10] and in Deep Eutectic Systems (DESs) [11] were investigated. The latter, described first by [PERSON] et al., represents a cheaper, less toxic, and facile option among the low-transition temperature mixtures [12]. Additionally, their low water contents and low water activities lead lipases to reverse their activity and form ester bonds using relatively mild and harmless conditions [13]. Numerous applications of DESs in environmentally friendly chemical processes have been made, notably for the production of pharmaceutically relevant building blocks and scaffolds [14; 15; 16]. Moreover, DESs can also be used for the extraction of valuable compounds such as phenolics contained in olive oil wastes [17], adding them as a sustainable tool for food waste treatment and re-volarization. In our similar and inherently benign approach, sorbitol is simultaneously part of the solvent as a DES partner, in combination with choline chloride, and part of the lipase-catalyzed reaction as a substrate. Intrinsically, this reaction design solves solubility problems of the polyols while saturating the system with the acyl acceptor. This \"2-in-1\" principle described first by [PERSON] et al. [18], using notably C4 to C6 sugars in combination with vinyl fatty esters, presented however exceptionally low yields (~4%) and lacked proof of scalability [19]. The use of vinyl esters for SE synthesis, described by [PERSON] et al., is thermodynamically favored as the vinyl adduct is converted during the reaction to the side-product ethanol, which itself tautomerizes in the highly volatile acetaldehyde [20] (Figure 1). For the first time, we enhanced further the conversion yield of this advantageous system, using a relatively better acyl acceptor for the reaction [21].