## 1 Introduction  
Viticulture is one of the most important agricultural activities in the world; in 2018 approximately 7.4 million hectares were cultivated globally, of which 4.3 million hectares were cultivated in Europe. Statistics place Spain in first place regarding the areas cultivated with grape vines (969,000 hectares); in second place is China (875,000 hectares); in third place is France (793,000 hectares) [1]. The average number of byproducts harvested from annual vine trimmings is 1.3 kg of wood/live log, thus \"accumulating\" to 2 \(\times\) 10\({}^{7}\) tons of wood in the world. The only use for this waste is to grind it and use it as a fertilizer, by distributing it on vineyards [2]. Recent studies have shown that vine waste from annual trimmings accumulate via a wide range of stillenoids, from resveratrol to complex stilbene oligomers [3]. Thereby, due to the fact that vine waste contains valuable bioactive substances, with potential applications in medicine and agriculture (due to multiple pharmacological and phytopathogenic properties), these can represent promising bioresources [4]. Stilbenoids are produced by plant secondary metabolisms and are a part of the non-flavonoid phenolic compound family. They are synthetized by plants as defense mechanisms in response to biotic and abiotic stresses. There is increased interest surrounding stillenoids due to their potential effects on human health [5]. Stilbenes are a reduced group of phenylpropanoids characterized by a 1,2-diphenylethylene-ylene general structure. Plant stilbenes are derived from the general phenylpropanoidpathway [6]. Only a few plant species are capable of producing stilbenes, although all higher plants can synthesize esters of cinnamic acid derivatives and malonyl-CoA. The first enzymes of the phenylpropanol pathway are phenylalanine ammonia lyase (PAL), cinnamate-4-hydroxylase (C4H), and 4-comamate: CoA ligase (4 CL). Stilbene synthase (STS) catalyzes, in a single reaction, the biosynthesis of stilbene's general structure from one CoA-ester of a cinnamic acid derivative (p-coumaroyl-CoA--most (or frequently) cinnamoyl-CoA) and three molecules of malonyl-CoA, and is only characteristic to plants that are able to produce stilbene [7]. First, the purified protein of the STS gene was from the stressed cell suspension cultures of the peanut (_Arachis hypogaea_) [8]. Subsequently, Scots pine (_Pinus sylvestris_) and grape (_Vitis viinifera_) were used to clone STS genes [9]. STS genes are found in many plant species as families of related genes. The vine was the only plant capable of producing stilbene, whose genome was sequenced until recently. It has been demonstrated in early studies that more than 20 STS genes are contained by the grapevine genome [10]. The large size of the multigene family was confirmed by an analysis of the first sketch of the grapevine genome, with an estimated 20-40 STS genes. A minimum of 20 different STS genes are expressed in the grape after infection with _Plasmapara viticola_[11]. Resveratrol is synthesized in grape vines using three molecules of malonyl-CoA and one molecule of coumaroyl-CoA, by the catalysis of stilbene synthase (EC 2.3.1.95; STS, malonyl-CoA:4-coumaroyl-CoA malonyltransferase). Most stilbenes synthesized by plants are derived from the basic unit trans-resveratrol (_trans_-3,5_,4_\({}^{\prime}\)-trihydroxystilbene) [12]. Generally, plants synthesize trans-resveratrol (3,5_,4_\({}^{\prime}\)-trihydroxystilbene) as a phytoalexin, naturally, in response to exogenous factors, such as ultraviolet (UV) irradiation, traumatic damage, pathogen infection, and other stresses. Only a few dietary sources have been found to contain this compound; the main representatives being peanuts, grapes, hops, strawberries, blueberries, and the products derived therefrom [13].