## 4 Discussion
The interaction between the oils and receptor is at a noncompetitive antagonist site that is crucial in the mechanism of the other AMPAR biophysical properties. Hence, desensitization is caused by ion channel pore closure without the disassociation of the ligand from the receptor. On the contrary, the deactivation of AMPARs is characterized as the natural decay in current after the dissociation of glutamate from the receptor and closure of the channel gate [25; 26]. Computational ligand docking is needed to assess how the action of these oils targets all kinetics of the receptor's activation, deactivation, and desensitization. Nonetheless, reducing the desensitization and deactivation rates of AMPARs indirectly portrays neuroprotective properties as this will reduce the signal transduction and excessive activation of AMPARs, which is of pharmaceutical significance in treating epilepsy, ALS, and other neurological diseases. However, only one pharmaceutical drug is currently in the market and is known as Perampanel. This drug is primarily used as an antiepileptic drug, yet has numerous serious side effects such as depression, anxiety, paranoia, weight gain, and joint and back pain [21]. In response, the current study investigates two conventional essential oils; the Citronellol oil as possible AMPAR antagonist. In attempt to reduce the side effect seen from Perampanel these oils have been documented to be antidepressant, anti-inflammatory, diuretics etc., hence the result of the study indicates that not only do they inhibit AMPARs, but also provide a natural antagonist of no side effects. In the same manner as the reduction in peak current, the desensitization and deactivation rates also decreased, insinuating the action of EOs target all biophysical properties of the AMPAR subunits in the same way. The level of inhibition between the EOS was distinct as the Citronellol oil inhibited AMPARs subunit by four folds while the Geraniol oil inhibition was by only three-fold. Moreover, the inhibition between AMPAR subunits was also biased in that specific subunits were more susceptible to inhibition than others hence, the AMPAR subunit that was significantly impacted the most was GluA1 followed by its heteromeric subunit GluA1/A2, then GluA2 and, finally, GluA2/3. Both oils portrayed the same bias to specific AMPAR subunits, suggesting the action of these oils is similar and target the same antagonist site. However, due to the discrepancy seen in inhibition, the Citronellol is a more favorable and stable antagonist for AMPARs than the Geraniol oil. Although both oils favor certain AMPAR subunits, they remained to significantly inhibit all tested subunits, which is critical significance because unlike Talampanel that failed in clinical trials, due to its effectiveness on certain AMPAR subunits [22], these oils deploy their neuroprotective properties on all AMPARs. Finally, the inhibition of both essential oils was irrelevant to glutamate concentration, suggestion they act as non-competitive inhibitors. Due to excessive concentration of glutamate and as a result over activation of AMPARs, noncompetitive inhibitors are a significantly important and desirable target in drug synthesis to treat the disease associated with AMPARs. The administration of multi-components or single essential oils or their constituents in conventional medicine, complementary/alternative medicine, folk medicine, and aromatherapy has been known for a long time, and its relevance is steadily growing [17; 18]. In the last few years, many scientific investigations have been established to assess the effectiveness and the mechanisms of action of these compounds on the central nervous system [19; 20]. Previously, we have shown no inhibitory effect from _Origanum srivicum_ L. and _Lavandula dentate_ L. essential oils on any of the tested AMPAR subunits [6]. Although they influenced the desensitization and deactivation of the AMPARs, the results given previously were not as significant in comparison to the present oils that non-competitively inhibit AMPARs.