# Deep Eutectic Solvents as Extraction Media for
## 2 Factors Affecting the Extraction of Flavonoids Using DES Separation Techniques
### Separation Techniques
\begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Plant Source** & **DES** & **Target Flavonoids** & **Biostivity** & **Ref.** \\ \hline \multirow{4}{*}{_Horth artensionic scepurarie_} & \multicolumn{4}{c}{Formic acid} \\  & & Aortic acid & & \\  & & Propionic acid & Rutin & Anti-inflammatory, antibacterial, and \\  & & Glycerol & Quercetin & anti-oxidant properties. & [45] \\  & & & Urea & Scopurgene & \\  & & 1,2-Butaned & & \\  & & & 1,4-Butaned & & \\ \hline \multirow{4}{*}{_Mentha Piperies L_} & \multirow{4}{*}{Critic Acid} & Glycerol (1:2) & & \\  & & Xylitol (1:1) & & \\  & & D (+)-Glucose (1:1) & & \\ \cline{2-5}  & & & Glycerol (2:1) & & \\  & & Xylitol (2:1) & & \\  & & D (+)-Glucose (2:1) & & \\ \hline \multirow{4}{*}{_Screditlinkiasis Georgia_} & \multirow{4}{*}{ChCI (1:1)} & \multicolumn{4}{c}{Lactic acid} \\  & & Glucose & & \\  & & Glycerol & & \\  & & 1,4-Butaned & & \\  & & Ethylene Glycol & & \\ \hline \multirow{4}{*}{Cyclocarp-pairairs (Batal.)} & \multirow{4}{*}{ChCI} & Glucose (2:1) & & \\  & & Citric acid (1:1) & & \\  & & Glycerol (1:1) & & \\  & & Urea(1:1) & & \\  & & Clinic Acid/Glycerol (1:1) & Multiple flavonoids & N/A (bioactivity not directly attributed to \\  & & & 1,4-Butaned (1:1) & & flavonoids). \\  & & & Lact acid (1:1) & & \\  & & Malonic acid (1:1) & & \\  & & Malic Acid/Glyscale Alcohol (1:1) & & \\ \hline \multirow{4}{*}{_Palion hyphae_} & \multirow{4}{*}{ChCI} & 1,4-Butaned (1:4) & & \\  & & Glucose (1:4) & & \\  & & Glycerol (1:4) & & \\ \cline{1-1}  & & & Acetle acid (1:4) & & \\ \cline{1-1}  & & Ethylene Glycol (1:0) & & \\ \cline{1-1}  & & 1,2-Propaned (1:3) & & \\ \cline{1-1} \cline{2-5}  & & L-proline & Glycerol (4:1) & & \\ \hline \hline \end{tabular}
\end{table} 
Table 2: _Cont._ \begin{table}
\begin{tabular}{c c c c c} \hline \hline
**Plant Source** & **DES** & **Target Flavonoids** & **Biectivity** & **Ref.** \\ \hline \hline \multirow{6}{*}{Ginlage Rieken} & Multiple DES based on ChCl, betaine, proline, & & \multicolumn{2}{c}{Protection against capillary fragility,} \\  & 1,3-Butanediol, 1,2-Propanediol and xylitol with numerous & Multiple flavonoids & anti-inflammatory agents, anti-oxidants, \\  & & components & & reduction of edema caused by tissue injury, free \\ \hline \multirow{2}{*}{Orange Peels} & \multirow{2}{*}{ChCl} & Glycerol (1.2:13;1:4) & Phenolic anti-oxidants (gallic acid, ferritic acid, \\  & Ethylene Glycerol (1.2:13;1:4) & para-counamic acid) & Antibiotics, anti-inflammatory, anti- allergic. \\ \hline \multirow{2}{*}{_Moring Oleifera_} & \multirow{2}{*}{ChCl} & \multirow{2}{*}{Cirtic acid} & Flavonoids, among other \\  & & & compounds & anti-inflammatory, anti-inflammatory, and anti-inflammatory, and anti-epidemic activities. \\ \hline \multirow{2}{*}{_Jaganus Rgia L._} & \multirow{2}{*}{ChCl (1:2)} & Butyric acid & Quercetin and miscellaneous \\  & & Phenylpropionic acid & compounds & N/A \\ \hline \multirow{6}{*}{Sea Buckwood Leaves} & \multirow{6}{*}{ChCl (1:1)} & Citric acid & \multirow{6}{*}{Rutin} \\  & & Malic acid & \\  & & Lactic acid & & \\  & & Ethylene Glycerol & & \\  & & 1,3-butanediol & Rutin & Anti-oxidant, cytoprotective, \\  & & 1,4-butanediol & Quercetin-3-O-glucose & immune-modulatory, cardioprotective, \\  & & 1,6-hexhenediol & Quercetin & anti-inflammatory, and wound-healing activity. \\  & & & Glycerol & \\  & & Glucose & & \\  & & & Fructose & \\  & & & Sactors & \\ \hline \multirow{6}{*}{Radix Scotellurie} & \multirow{6}{*}{ChCl} & Glycerol(1:4) & Scutellarin \\  & & Glycerol(1:4) & Baisalin \\  & & 1,2-Propylene(1:4) & Woogenine Bicialen & Antibacterial and antiviral action. \\ \cline{1-1}  & & 1,2-Butanediol(1:8) & Woogenin & \\ \cline{1-1}  & & Lactic acid(1:4) & & \\ \cline{1-1}  & & Malic acid(1:4) & & \\ \cline{1-1}  & & Glucose(1:4) & & \\ \hline \hline \end{tabular}
\end{table} 
Table 2: _Cont._