###### Abstract  
Heavy-metal contamination of the environment is a serious worldwide issue, as it presents dangerous threats to both human health and aquatic ecosystems. This has led to a paradigm shift toward the development of simple, user-friendly, and economically viable remediation technologies that are essential for addressing heavy-metal soil pollution and for the global preservation of the environment. This review provides a comprehensive overview of environmental remediation strategies using cyclodextrin (CD) and its derivatives. Additionally, this study examines the effectiveness of methylated gamma-cyclodextrintrin (M-\(\gamma\)-CD) as a modified oligosaccharidesaride for the elimination of toxic elements from impure soil matrices. M-\(\gamma\)-CD has emerged as a potent agent for treating soil impurities with noxious metals. As a modified form of cyclodextrin, M-\(\gamma\)-CD features hydrophobic cavities that are particularly adept at forming inclusion complexes with heavy-metal ions, thereby cumulating the aqueous solubility and efficiency of pollutants in environmental applications and improving soil bioremediation. This paper also reviews the unique structural configuration of M-\(\gamma\)-CD, which significantly enhances the solubility and mobility of cyclodext and facilitates the extraction of noxious metal particles such as Ni, Cu, and Pb from soil matrices. Furthermore, M-\(\gamma\)-CD is a promising soil remediation agent due to its capacity to boost contaminant solubility, improve environmental safety, offer cost-effectiveness, ensure adaptability, and minimize impact on soil parameters. Therefore, M-\(\gamma\)-CD is a desirable agent for the elimination of toxic metal impurities from soil. environmental contamination; inclusion complex formation; native cyclodextrin; encapsulation; hydrophobic cavity [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] [26] [27] [28] [29] [30] [31] [32  
waste disposal. In agricultural regions, livestock manure comprising poultry, bovine, and porcine exceta is commonly used as organic fertilizer. However, these manures often contain a high number of noxious metals such as copper (Cu), zinc (Zn), arsenic (As), nickel (Ni), lead (Pb), cadmium (Cd), chromium (Cr), and mercury (Hg). Moreover, these metals can enter aquatic ecosystems via agricultural runoff, industrial effluents, and poor waste management [3; 5; 6], where they persist and accumulate in aquatic organisms, promoting bioaccumulation and biom magnification over the entire ecosystem [7]. In recent decades, various remediation strategies using physical, chemical, and biological methodologies have been developed to reduce heavy-metal accumulation in the soil. Key techniques include phytoremediation (using plants), bioremediation (employing microorganisms), and immobilization (chemically altering metals) [1]. Traditional methods face challenges such as high costs, ineffectiveness, and the risk of secondary contamination. Despite progress, creating effective, scalable solutions remains difficult. Therefore, this study aimed to expand on bioremediation and novel chemical extraction techniques that employ cyclodext and their derivatives as effective tools for soil remediation [2]. Cyclodextrin (CD) molecules, which are cyclic oligosaccharides derived from enzymatically treated starch, come in various forms, such as \(\alpha\), \(\beta\), and \(\gamma\)[8]. CDs and their derivatives possess hydrophobic cavities that facilitate the formation of inclusion complexes with contaminants like heavy metals, organic pollutants, and pharmaceutical residues [9]. Notably, their ability to sequester heavy metals without forming covalent bonds enhances their applicability for addressing contamination issues [9; 10; 11; 12]. This manuscript investigates the efficacy of methylated gamma-cyclodextrintrin (M-\(\gamma\)-CD) as a novel and effective agent for extracting heavy metals from contaminated soils.