# DIVA Meets EEG: Model Validation Using Formant-Shift Reflex
## 5 Conclusions  
The extension of DIVA to include a new neuroimaging modality (EEG) will expand the use of this neurocomputational tool for assessing different aspects of speech motor control, including sensorimotor integration and predictive coding. DIVA_EEG was validated using group-level statistics of the behavior and the EEG acquired from volunteers with typical voices. Further research is needed to ascertain if the configuration parameters of DIVA_EEG can predict vocal compensatory behaviors and brain activation at individual level. Subject-specific simulations can be fostered by incorporating vocal fold control models, as carried out in LaDIVA [63], which provide a complete set of biomechanical parameters for vocal function assessment. In fact, vocal fold models associated with LaDIVA have been successfully used for subject-specific modeling of vocal hyperfunction [101]. Likewise, further extension of DIVA_EEG may consider neurophysiological muscle activation schemes for controlling vocal fold models [102] for assessing reflective and adaptive vocal behaviors at the laryngeal level. The latter may incorporate the parametrization of the sensory adaptation elicited by continuous and repetitive stimulation [103,104]. These developments are the foundations for constructing a complete and comprehensive neurocomputational framework to tackle vocal and speech disorder, which can guide model-driven personalized interventions. The following supporting information can be downloaded at: [[https://www.mdpi.com/article/10.3390/app13137512/s1](https://www.mdpi.com/article/10.3390/app13137512/s1)]([https://www.mdpi.com/article/10.3390/app13137512/s1](https://www.mdpi.com/article/10.3390/app13137512/s1)), Table S1: Cortical regions selected as seeds in DIVA_EEG, Figure S1: Synthetic EEG (DIVA_EEG) traces, and electrode layout, Table S2: Numbers of active voxels in AAL90 areas in DIVA model simulations, Table S3: Numbers of active voxels in AAL90 areas reflecting the cortical activity in feedback reflexive paradigms, Numbers of active voxels in AAL90 areas reflecting the by cortical activity in auditory feedback reflexive paradigms, Table S4: Numbers of active voxels in AAL90 areas by cortical activity when comparing DIVA-EEG model and real EEG, Figure S2: Example of compensations in the same direction of the down- shift F1, Table S5: Cohen Effect Size of the cortical activations. Conceptualization: J.C., E.M.-M., P.P. and M.Z. ; methodology, J.C., P.P. and E.M.-M.; software, J.C., A.W., M.O., E.M.-M. and C.C. ; validation, J.C., L.Z.-R., A.W. and C.C. ; formal analysis, J.C., L.Z.-R., M.O. and P.P. ; investigation, J.C. and P.P. ; resources, M.Z. ; data curation, J.C. and L.Z.-R.; writing--original draft preparation, J.C., G.W. and P.P. ; writing--review and editing, J.C., G.W., P.P. and M.Z. ; visualization, P.P. and J.C.; supervision, P.P. and M.Z. ; project administration, M.Z. ; funding acquisition, M.Z. All authors have read and agreed to the published version of the manuscript. This research was funded in part by the U.S. National Institutes of Health (NIH), National Institute on Deafness and Other Communication Disorders Grant P50 DC015446 (M.Z. ), Agencia Nacional de Investigacion y Desarrollo de Chile (ANID) grants BASAL FB0008 (M.Z. ), FONDECYT 1230828 (M.Z. ), FONDECYT 1231132 (A.W. ), FONDECYT Postdoctorado 3210508 (M.O. ), BASAL FB210008 (M.O.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The study was conducted in accordance with the Declaration of Helsinki, and approved by the Institutional Review Board of Universidad de Valparaiso (protocol code 52015, approved on April 2019). Informed Consent Statement:Informed consent was obtained from all subjects involved in the study. Data Availability Statement:The data presented in this study are available on request from the corresponding author to protect the personal information of participants. Conflicts of Interest:M.Z. and A.W.