## 4 Conclusions  
In this study, a simple, rapid, and on-site applicable SPME Arrow-PMS method for the selective and quantitative detection of five veterinary drugs in food was developed. This method eliminates the need for chromatographic separation, allowing detection within 30 s with LODs ranging from 2.8 to 9.3 \(\upmu\)g L\({}^{-1}\). The durability and enhanced extraction efficiency of the SBA-15-SPME Arrow make it a strong candidate for incorporation into routine food safety inspections and other high-throughput screening environments. Compared to commercially available SPME Arrows, the SBA-15-coated Arrow showed superior extraction performance, offering greater sensitivity and selectivity while requiring only 1 \(\upmu\)L of the desorbed sample. These features make it highly suitable for real-time food safety monitoring. The SBA-15-SPME Arrow not only improves sensitivity and precision but also reduces costs, making it a viable tool for large-scale screening of veterinary drug residues in food products. The SPME Arrow-PMS method offers a portable, cost-effective solution for on-site food safety monitoring, enhancing both detection speed and accuracy. Its potential for routine screening of veterinary drug residues in dairy products and meat suggests broader utility in routine food safety inspections. **Supplementary Materials:** The following supporting information can be downloaded at: [[https://www.mdpi.com/article/10.3390/foods13203337/s1](https://www.mdpi.com/article/10.3390/foods13203337/s1)]([https://www.mdpi.com/article/10.3390/foods13203337/s1](https://www.mdpi.com/article/10.3390/foods13203337/s1)), text S1. Synthesis of SBA-16, MCM-41, and UIO-66 series materials; Figure S1: Optimization of SPME Arrow coating procedures: (a) material proportion in the electrospinning solution, (1) 0.1 g PAN + 0.1 g SBA-15 + 2 mL DMF, (2) 0.1 g PAN + 0.2 g SBA-15 + 3 mL DMF, (3) 0.1 g PAN + 0.3 g SBA-15 + 4 mL DMF, (4) 0.2 g PAN + 0.1 g SBA-15 + 3 mL DMF, (5) 0.2 g PAN + 0.2 g SBA-15 + 4 mL DMF, (6) 0.3 g PAN + 0.1 g SBA-15 + 4 mL DMF; (b) electrospinning time; Figure S2. SEM images of SBA-15-SPME Arrow at different spinning times (a) Bare SPME Arrow (diameter = 0.98 mm); (b) 20 min (coating thickness = 0.27 mm); (c) 30 min (coating thickness = 0.34 mm); (d) 50 min (coating thickness = 0.6 mm); (e) 60 min (coating thickness = 0.53 mm); Figure S3. Optimization of the extraction and desorption conditions of PDMS Smart SPME Arrow: (a) extraction time, (b) desorption solvents (1. methanol:water = 7:3, 2. acetonitrile:water = 7:3, 3. methanol:water = 9:1, 4. acetone:water = 7:3) and (c) desorption time; Figure S4. Optimization of the extraction and desorption conditions of Polyacrylate Smart SPME Arrow: (a) extraction time, (b) desorption solvents (1. methanol:water = 7:3, 2. acetonitrile:water = 7:3, 3. methanol:water = 7:3) and (c) desorption time; Figure S5. Optimization of the extraction and desorption conditions of Carbon WR/PDMS Smart SPME Arrow: (a) extraction time, (b) desorption solvents (1. methanol:water = 7:3, 2. acetonitrile:water = 7:3, 3. methanol:water = 9:1, 4. acetone:water = 7:3) and (c) desorption time; Figure S6. Optimization of the extraction and desorption conditions of DVB/Carbon WR/PDMS Smart SPME Arrow: (a) extraction time, (b) desorption solvents (1. methanol:water = 7:3, 2. acetonitrile:water = 7:3, 3. methanol:water = 9:1, 4. acetone:water = 7:3) and (c) desorption time; Figure S7 Optimization of the extraction and desorption conditions of DVB/PDMS Smart SPME Arrow: (a) extraction time, (b) desorption solvents (1. methanol:water = 7:3, 2. acetonitrile:water = 7:3, 3. methanol:water = 7:3) and (c) desorption time; Figure S8 Optimization of the SBA-15-SPME Arrow with five veterinary drugs. **Author Contributions:** Conceptualization, H.L. and X.L. ; methodology, H.L. and X.L. ; software, H.L. and X.L. ; validation, H.L., X.L. and Z.W. ; investigation, H.L., X.L. and D.P. ; writing--original draft preparation, H.L., X.L. and Z.W. ; writing--review and editing, H.L., X.L. and Z.W.