## 3 Experimental Section
### Synthesis of Compounds 7-**10** from Natural Products  
_3-(4-Hydroxy-3-methoxyphenyl)-2-methyl-2H,3H-[1,4]thiazo[2,3,4-ij]quinolin-4-ium chloride_ (7). A solution of sulffuryl chloride (0.113 g, 0.83 mmol) in chloroform (10 mL) was added dropwise to a solution of di(8-quinolinyl) disulfide (0.268 g, 0.83 mmol) in chloroform (10 mL), and the mixture was stirred for 10 min at room temperature. A solution of isoeigenol (0.274 g, 1.6 mmol) in chloroform (10 mL) was added dropwise, and the reaction mixture was stirred for 45 h at room temperature and left overnight. The formed precipitate was filtered off, washed with hexane and dried in vacuum, giving the product (0.54 g, 90% yield) in the form of a yellow powder, mp 156-159 \({}^{\circ}\)C.  
\({}^{1}\)H-NMR (400 MHz, DMSO-\(d_{6}\)): 8 1.40 (d, \(J\) = 7.0 Hz, 3H, CH\({}_{3}\)), 3.70 (s, 3H, OCH\({}_{3}\)), 3.96 (m, 1H, SCH), 5.73 (m, 1H, NCH), 6.58 (m, 1H, Ar), 6.61 (m, 1H, Ar), 6.80 (m, 1H, Ar), 7.94-7.98 (m, 1H, Hquino), 8.14-8.16 (m, 1H, Hquino), 8.24-8.27 (m, 1H, Hquino), 8.32-8.34 (m, 1H, Hquino), 9.43-9.45 (m, 1H, Hquino), 9.48-9.50 (m, 1H, Hquino). \({}^{13}\)C-NMR (101 MHz, DMSO-\(d_{6}\)): 8 20.04 (CH\({}_{3}\)), 37.46 (SCH\({}_{2}\)), 55.74 (OCH\({}_{3}\)), 73.69 (NCH), 110.39, 115.40, 117.77, 122.94, 124.85, 127.68, 129.08, 129.70, 130.87, 132.96, 133.95, 147.17, 148.03, 150.25, 151.10. Anal. Calcd for C\({}_{19}\)H\({}_{18}\)NCIO\({}_{2}\)S: C 63.41, H 5.04, N 3.89, Cl 9.85, S 8.91. Found: C 63.69, H 5.23, N 4.07, Cl 10.09, S 9.21. _2-(4-Hydroxy-3-methoxyphenyl)methyl-2H,3H-[1,4]thiazo[2,3,4-ij]quinolin-4-ium chloride_ (8). A solution of sulffuryl chloride (0.167 g, 1.2 mmol) in chloroform added dropwise to a solution of di(8-quinolinyl) disulfide (0.396 g, 1.2 mmol) in chloroform (10 mL), and the mixture was stirred for 10 min at room temperature. A solution of eugenol (0.394 g, 2.4 mmol) in chloroform (10 mL) was added dropwise. The reaction mixture was stirred for 1 h at room temperature and 7 h at reflux and left overnight. The formed precipitate was filtered off, washed with hexane and dried in vacuum, giving the product (0.648 g, 75% yield) in the form of a yellow powder, mp 195-197 \({}^{\circ}\)C.  
\({}^{1}\)H-NMR (400 MHz, D\({}_{2}\)O): 8 28.2-9.94 (m, 1H, CH\({}_{2}\)), 3.02 (dd, \(J\) = 14.2, 6.0 Hz, 1H, CH\({}_{2}\)), 3.68 (s, 3H, CH\({}_{3}\)), 3.92-3.97 (m, 1H, SCH), 4.94 (dd, \(J\) = 14.4, 6.8 Hz, 1H, NCH\({}_{2}\)), 5.21 (dd, \(J\) = 14.4, 2.4 Hz, 1H, NCH\({}_{2}\)), 6.48-6.53 (m, 2H, Ar), 6.68 (s, 1H, Ar) 7.69-7.73 (m, 1H, Hquino), 7.80-7.82 (m, 1H, Hquino), 7.92-7.98 (m, 2H, Hquino), 8.96-9.00 (m, 2H, Hquino). \({}^{13}\)C-NMR (101 MHz, D\({}_{2}\)O): 8 36.84 (CH\({}_{2}\)), 37.18 (SCH), 55.34 (CH\({}_{3}\)), 61.78 (CH\({}_{2}\)N), 112.80, 114.59, 121.35, 121.70, 125.61, 126.51, 127.91, 129.14, 130.46, 132.69, 133.07, 143.36, 146.56, 148.55, 148.68. Anal. Calcd for C\({}_{19}\)H\({}_{18}\)NCIO\({}_{2}\)S: C 63.41, H 5.04, N 3.89, Cl 9.85, S 8.91. Found: C 63.73, H5.21, N 4.01, Cl 10.31, S 9.29. _3-(4-Methoxyphenyl)-2-methyl-2H,3H-[1,4]thiazo[2,3,4-ij]quinolin-4-ium chloride_ (9). A solution of sulffuryl chloride (0.103 g, 0.76 mmol) in methylene chloride (10 mL) was added dropwise to a solution of di(8-quinolinyl) disulfide (0.243 g, 0.76 mmol) in methylene chloride (10 mL), and the mixture was stirred for 10 min at room temperature. A solution of _trans_-anethole (0.226 g, 1.52 mmol) in methylene chloride (10 mL) was added dropwise, and the reaction mixture was stirred for 48 h at room temperature. The solvent was removed by rotary evaporator.