## 3 Results
muricata_ leaf ethanol extract using LC-MS/MS analysis. Based on Table 3, the \(p\)-value > 0.05 were found in most treatment groups. It indicated that the experimental data were normally distributed. The \(p\)-value of Bowman's space width of left kidney were > 0.05 in positive control, low-dose ethanol extract of soursop leaf (LD-SLEE), medium-dose ethanol extract of soursop leaf (MD-SLEE), and high-dose ethanol extract of soursop leaf (HD-SLEE) groups. It indicated that these treatment gorups have a normal data distribution. However, the negative control group had an abnormal data distribution with a \(p\)-value of 0.006 (\(p<0.05\)). The histopathology analyses of renal glomerular diameters, [PERSON]'s space width, the thickness of proximal convoluted tubule, and renal glomerular tubularization of both left and right kidneys were performed by Hematoxylin and Eosin (H&E) staining at 400\(\times\) magnification under light microscopy, as depicted in Figure 4.  
The analysis of the data distribution using Shapiro-Wilk test showed a \(p\)-value > 0.05 in each treatment group of [PERSON]'s space width of the right kidney. It showed that the distribution of data in each group of [PERSON]'s space width of right kidney is normally distributed (Table 4). [PERSON]'s test was used to perform data variant homogeneity of a diameter of renal glomerulus in left kidney had a \(p\)-value of 0.794 (\(p>0.05\)), indicating that the data variant was homogeneous. The results of Kruskal-Wallis test from right kidney glomerular diameter had a \(p\)-value of 0.917 (\(p>0.05\)), showing no significant difference in the mean between treatment groups. Therefore, Mann-Whitney post hoc test was not performed. The results of Kruskal-Wallis test from [PERSON]'s space width of left kidney had a \(p\)-value of 0.072 (\(p>0.05\)), which showed no significant difference in the mean between the treatment groups. Thus, Mann-Whitney post hoc test was not performed. Meanwhile, [PERSON]'s test results from [PERSON]'s space width of right kidney had a \(p\)-value of 0.319 (\(p>0.05\)) in each treatment group, showing that data variance in each treatment group was homogeneous. \begin{table}
\begin{tabular}{c c c c} \hline \hline
**Variable** & **Treatment Group** & **Mean \(\pm\) SE *** & \(p\)-Value** \\ \hline \multirow{6}{*}{Right kidney [PERSON]’s space width} & Negative control & 37.33 \(\pm\) 4.02 & 0.426 * \\  & Positive control & 68.57 \(\pm\) 7.23 & 0.538 * \\  & LD-SLEE & 80.75 \(\pm\) 16.77 & 0.540 * \\  & MD-SLEE & 93.46 \(\pm\) 18.89 & 0.231 * \\  & HD-SLEE & 102.60 \(\pm\) 14.41 & 0.540 * \\  & Negative control & 54.32 \(\pm\) 2.19 & 0.134 * \\  & Positive control & 56.23 \(\pm\) 4.85 & 0.826 * \\  & LD-SLEE & 64.13 \(\pm\) 3.19 & 0.449 * \\  & MD-SLEE & 62.24 \(\pm\) 1.94 & 0.351 * \\  & HD-SLEE & 54.01 \(\pm\) 3.15 & 0.718 * \\  & Negative control & 59.22 \(\pm\) 1.55 & 0.291 * \\  & Positive control & 55.37 \(\pm\) 2.98 & 0.436 * \\ The thickness of the proximal convoluted & LD-SLEE & 58.48 \(\pm\) 1.65 & 0.268 * \\ tubule of the right kidney & MD-SLEE & 52.87 \(\pm\) 5.82 & 0.123 * \\  & HD-SLEE & 47.33 \(\pm\) 5.40 & 0.761 * \\  & Negative control & 23.80 \(\pm\) 1.77 & 0.057 * \\  & Positive control & 13.20 \(\pm\) 1.14 & 0.090 * \\ Left renal glomerular tubularization & LD-SLEE & 17.60 \(\pm\) 1.60 & 0.377 * \\  & MD-SLEE & 15.00 \(\pm\) 1.81 & 0.627 * \\  & HD-SLEE & 9.20 \(\pm\) 3.32 & 0.808 * \\  & Negative control & 26.40 \(\pm\) 1.40 & 0.032 \\  & Positive control & 18.20 \(\pm\) 3.27 & 0.363 * \\ Right renal glomerular tubularization & LD-SLEE & 24.00 \(\pm\) 3.42 & 0.587 * \\  & MD-SLEE & 17.80 \(\pm\) 1.35 & 0.492 * \\  & HD-SLEE & 13.00 \(\pm\) 5.18 & 0.283 * \\ \hline \hline \end{tabular}  
* SE: standard error;
* \(p>0.05\) indicated normal data distribution. LD-SLEE = low-dose ethanol extract of soursop leaf; MD-SLEE = medium-dose ethanol extract of soursop leaf; HD-SLEE = high-dose ethanol extract of soursop leaf.  
\end{table} 
Table 3: _Cont._Figure 3: Bioactive compound structures found in _A.