## 3 Results and Discussion
### Effects on Toxicity
\begin{table}
\begin{tabular}{c c c c c c c} \hline \hline  & \multicolumn{2}{c}{**Parameters**} & \multicolumn{2}{c}{**Group for Acute Toxicity**} & \multicolumn{2}{c}{**Group for Subacute Toxicity**} \\ \cline{3-6}  & & **Control** & **ADCP-Treated** & **Control** & **ADCP-Treated** \\ \hline \multirow{4}{*}{Bodyweight gain} & \multirow{2}{*}{Female} & Bodyweight gain (g) & 57.20 \(\pm\) 5.70 & 59.50 \(\pm\) 3.53 & 64.20 \(\pm\) 5.98 \({}^{\mathrm{a}}\) & 46.00 \(\pm\) 2.13 \({}^{\mathrm{b}}\) \\  & & Food intake (g/day) & 22.20 \(\pm\) 0.82 & 22.02 \(\pm\) 1.87 & 24.09 \(\pm\) 1.06 & 21.73 \(\pm\) 0.21 \\ \cline{2-6}  & & Water intake (ml/day) & 23.48 \(\pm\) 0.33 & 25.12 \(\pm\) 0.04 & 24.04 \(\pm\) 1.09 & 27.36 \(\pm\) 2.30 \\ \cline{2-6}  & & Bodyweight gain (g) & 133.70 \(\pm\) 4.06 & 111.50 \(\pm\) 1.55 & 125.20 \(\pm\) 4.84 \({}^{\mathrm{a}}\) & 93.60 \(\pm\) 5.63 \({}^{\mathrm{b}}\) \\ \cline{2-6}  & \multirow{2}{*}{Male} & \multirow{2}{*}{Male} & Food intake (g/day) & 29.01 \(\pm\) 1.98 & 28.38 \(\pm\) 1.54 & 28.42 \(\pm\) 1.03 & 24.56 \(\pm\) 0.73 \\  & & Water intake (ml/day) & 29.28 \(\pm\) 1.23 & 28.46 \(\pm\) 0.10 & 32.70 \(\pm\) 0.75 & 26.79 \(\pm\) 0.04 \\ \hline \multirow{4}{*}{Hematological parameters} & \multirow{4}{*}{Female} & RBC (\(\times 10^{6}\)/ml) & 7.47 \(\pm\) 0.33 & 7.53 \(\pm\) 0.29 & 7.47 \(\pm\) 0.19 \({}^{\mathrm{b}}\) & 7.76 \(\pm\) 0.16 \({}^{\mathrm{b}}\) \\  & & WBC (\(\times 10^{6}\)/ml) & 7.29 \(\pm\) 0.69 \({}^{\mathrm{b}}\) & 10.19 \(\pm\) 1.14 \({}^{\mathrm{b}}\) & 7.29 \(\pm\) 0.40 & 8.36 \(\pm\) 0.85 \\  & & Hot (c/day) & 58.98 \(\pm\) 2.62 & 58.23 \(\pm\) 1.88 & 58.98 \(\pm\) 15 \({}^{\mathrm{b}}\) & 59.16 \(\pm\) 0.73 \({}^{\mathrm{b}}\) \\  & & Hgb (g/dL) & 15.73 \(\pm\) 0.66 & 15.25 \(\pm\) 0.38 & 15.73 \(\pm\) 0.38 \({}^{\mathrm{b}}\) & 16.04 \(\pm\) 0.26 \({}^{\mathrm{b}}\) \\  & & MCV (H) & 78.88 \(\pm\) 0.28 & 77.53 \(\pm\) 1.26 & 78.88 \(\pm\) 0.16 \({}^{\mathrm{a}}\) & 76.28 \(\pm\) 0.91 \\  & & MCH (pg/dL) & 21.05 \(\pm\) 0.21 & 20.33 \(\pm\) 0.36 & 21.05 \(\pm\) 0.12 & 20.06 \(\pm\) 0.25 \\  & & MCHC (g/dL) & 26.68 \(\pm\) 0.30 & 26.23 \(\pm\) 0.18 & 26.68 \(\pm\) 0.17 \({}^{\mathrm{b}}\) & 27.12 \(\pm\) 0.34 \({}^{\mathrm{a}}\) \\  & & Platelets (\(\times 10^{6}\)/ml) & 1476.75 \(\pm\) 216.80 & 1349.75 \(\pm\) 153.03 & 1476.75 \(\pm\) 125.17 & 1390.80 \(\pm\) 119.25 \\ \hline \multirow{4}{*}{Male} & \multirow{4}{*}{Male} & RBC (\(\times 10^{6}\)/ml) & 7.47 \(\pm\) 0.27 & 7.13 \(\pm\) 0.25 & 7.28 \(\pm\) 0.31 \({}^{\mathrm{a}}\) & 7.30 \(\pm\) 0.75 \({}^{\mathrm{a}}\) \\  & & WBC (\(\times 10^{6}\)/ml) & 8.96 \(\pm\) 0.98 & 8.94 \(\pm\) 0.96 & 8.71 \(\pm\) 0.78 & 7.40 \(\pm\) 0.37 \\  & & Hot (c/day) & 62.00 \(\pm\) 1.85 & 60.00 \(\pm\) 1.95 & 60.35 \(\pm\) 1.33 \({}^{\mathrm{a}}\) & 60.30 \(\pm\) 4.40 \({}^{\mathrm{b}}\) \\  & & HB (g/dL) & 15.66 \(\pm\) 0.47 & 15.05 \(\pm\) 0.46 & 15.28 \(\pm\) 0.33 & 13.95 \(\pm\) 2.35 \\  & & MCV (H) & 83.08 \(\pm\) 1.03 & 84.13 \(\pm\) 0.65 & 83.13 \(\pm\) 1.83 & 82.95 \(\pm\) 2.45 \\  & & MCH (pg) & 20.96 \(\pm\) 0.25 & 21.10 \(\pm\) 0.18 & 21.00 \(\pm\) 0.45 \({}^{\mathrm{a}}\) & 19.05 \(\pm\) 1.25 \({}^{\mathrm{b}}\) \\  & & MCHC (g/dL) & 25.24 \(\pm\) 0.08 & 25.08 \(\pm\) 0.19 & 25.28 \(\pm\) 0.06 & 23.00 \(\pm\) 2.20 \\  & & Platelets (\(\times 10^{6}\)/ml) & 1600.60 \(\pm\) 170.63 & 1877.50 \(\pm\) 339.03 & 1805.75 \(\pm\) 120.68 & 1197.00 \(\pm\) 286.00 \\ \hline \multicolumn{4}{l}{Values represent the mean \(\pm\) SE of five rats per group. In the acute toxicity test, the control group and the ADCP-treated group were orally administered a single dose of PBS and 5000 mg/kg of ADCP-treated CRCs, respectively, in a water vehicle, with no further treatment for 14 d. In the subacute toxicity test, the control group and the ADCP-treated group were orally administered PBS and 1000 mg/kg of ADCP-treated CRCs, respectively, in a water vehicle for 14 d. Differences between the control and samples (ADCP-treated) animals in acute or subacute toxicity treatment groups were evaluated using one-way ANOVA and [PERSON]’s multiple range tests. Different superscripts indicate significant differences (\(p<0.05\)) among groups (\(p<0.05\)). \\ \hline \end{tabular}
\end{table}