## 3 Results
### Analysis of EAT-REI Ratio High and Low Group  
The comparison of high and low EAT-REI groups shows no significant difference among the age, sex, BMI, CRP level, albumin level, lymphocyte count, triglyceride, and total cholesterol. In clinical T stage (\(p\) = 0.69), clinical N stage (\(p\) = 0.92), and cTNM stage (\(p\) = 0.72) also showed no significant difference (Table 4).  
\begin{table}
\begin{tabular}{l c c c} \hline \hline \multicolumn{1}{c}{**Characteristics**} & **EAT-REI \(\geq\) 68.8 (\(n\) = 23)** & **EAT-REI \(<\) 68.8 (\(n\) = 13)** & \(p\) **Value** \\ \hline Age (years), & \(57.3\pm 7.9\) & \(61.6\pm 9.4\) & 0.15 \\ Sex & & & 0.60 \\ Man & 22 (95.7\%) & \(12\) (92.3\%) & \\ Woman & 1 (4.3\%) & 1 (7.7\%) & \\ BMI (kg/m\({}^{2}\)) & 21.2 \(\pm\) 4.4 & 23.6 \(\pm\) 3.7 & 0.11 \\ CRP (mg/dL) & 7.0 \(\pm\) 6.2 & \(6.2\pm 5.5\) & 0.66 \\ Albumin (g/dL) & \(3.9\pm 0.5\) & \(4.0\pm 0.6\) & 0.71 \\ Hb (g/dL) & \(11.9\pm 1.4\) & \(12.3\pm 1.5\) & 0.38 \\ Lymphocyte (number/uL) & 1414.4 \(\pm\) 770.5 & 1744.2 \(\pm\) 631.4 & 0.20 \\ Cholesterol (mg/dL) & 178.6 \(\pm\) 48.6 & 186.4 \(\pm\) 18.8 & 0.60 \\ Triglycerides (mg/dL) & \(115.8\pm 52.9\) & \(116.8\pm 66.1\) & 0.77 \\ Metabolic diseases & 4 (17.4\%) & 2 (15.4\%) & 1.00 \\ Cardiac diseases & 4 (17.4\%) & 5 (38.5\%) & 0.24 \\ \hline \hline \end{tabular}
\end{table}
Table 4: Compare EAT-REI ratio with high and low patient groups.  
\begin{table}
\begin{tabular}{l c c c} \hline \hline  & **Univariate** & **Multivariate** & \\ \hline
**Characteristics** & **HR (95\% C)** & \(p\) **Value** & **HR (95\% C)** & \(p\) **Value** \\ \hline Metabolic diseases & 0.040 (0.000–20.334) & 0.311 & \\ Cardiac diseases & 0.344 (0.078–1.522) & 0.160 & \\ Clinical T (T1–2 vs. T3–4) & 0.904 (0.444–1.839) & 0.780 & \\ Clinical N (N0–1 vs. N2–3) & 1.524 (0.689–3.375) & 0.299 & \\ cTNM stage (II vs. III) & 0.828 (0.342–2.004) & 0.675 & \\ Pathological response (non-pCR vs. pCR) & 0.694 (0.288–1.669) & 0.414 & \\ Target Volume & 1.001 (1.000–1.002) & 0.164 & \\ Heart mean dose & 1.000 (0.999–1.000) & 0.663 & \\ Dose-volume of EAT \({}^{*}\) & & & \\ Volume (mL) & 0.982 (0.959–1.005) & 0.114 & \\ Mean dose (Gy) & 1.000 (0.999–1.000) & 0.751 & \\ V5 & 0.969 (0.943–0.996) & 0.026 & 1.131 (0.933–1.369) & 0.209 \\ V10 & 0.965 (0.935–0.996) & 0.049 & 0.796 (0.608–1.041) & 0.095 \\ V20 & 0.958 (0.918–1.000) & 0.049 & 1.116 (0.943–1.321) & 0.200 \\ V30 & 0.959 (0.902–1.029) & 0.182 & \\ V40 & 0.871 (0.735–1.032) & 0.111 & \\ REI of EAT (EAT-REI) & 1.003 (1.001–1.004) & 0.002 & 1.002 (1.000–1.004) & 0.030 \\ TAT volume (mL) & 0.999 (0.999–1.000) & 0.014 & 0.970 (0.998–1.000) & 0.060 \\ TAT mean dose (Gy) & 1.000 (0.998–1.002) & 0.896 & \\ SAT volume (mL) & 0.999 (0.999–1.000) & 0.018 & \\ SAT mean dose (Gy) & 1.000 (0.998–1.002) & 0.855 & \\ VAT volume (mL) & 0.995 (0.991–1.000) & 0.035 & 1.003 (0.995–1.010) & 0.458 \\ VAT mean dose (Gy) & 1.000 (0.999–1.001) & 0.739 & \\ \hline \hline \end{tabular} \({}^{*}\) VS = volume (mL) of EAT receiving X Gy or more. Abbreviations: CI, confidence interval; DVH, dose-volume histogram; REI, radiation exposure intensity; HR, hazard ratio; TAT, total adipose tissue.  
\end{table}
Table 3: _Cont._