# Adipolin, Chemerin, Neprilysin and Metabolic Disorders Associated with Obesity
## 4 Discussion
### Adipokines and Lipid Metabolism and Hypertension  
The role of the adipokines assessed in lipid metabolism is not well known. However, [PERSON] et al. observed that CTRP12 (\(\pm\)), CTRP12 (\(-/-\)), and wild-type mice differed in lipid and cholesterol metabolism. Their study showed, among other things, that mice partially deficient in the adipolin gene (CTRP12) had lower secretion of very low-density lipoproteins [6]. Furthermore, [PERSON] et al., in another study, showed that adipolin supply to mouse hepatocytes inhibits triglyceride synthesis [7]. Furthermore, in vitro studies proved that overexpression of the CTRP12 gene in mice reduces fasting and postprandial serum triglyceride levels [46]. The positive correlation between adipolin levels and triglyceride in non-obese women found in our study can be explained by some compensatory mechanism. Furthermore, the demonstrated negative correlation between adipolin concentrations and LDL-C in obese subjects with normal glucose tolerance confirms its protective effect in the context of disorders associated with obesity. The lack of differences in adipolin concentrations between the study group and the control group may be because some of the subjects in the control group had elevated total cholesterol and LDL-C concentrations. Therefore, the mean values of these parameters were comparable in both groups. Another study showed reduced adipolin levels in patients with coronary artery disease compared to healthy subjects [22]. A positive association between the concentration of adipolin and the occurrence of ischemic heart disease was observed by [PERSON] et al. [20]. In contrast, these authors did not demonstrate an association between blood adipolin concentrations and blood pressure values in patients with coronary artery disease [21; 22]. In our study, we observed a positive correlation between the concentration of the adipokine in question and systolic and diastolic blood pressure values in the control group. This relationship was particularly noticeable among women. The results of the study conducted so far suggest a possible link between CTRP12 and the pathomechanism of atherosclerosis, but further research is needed in this area. Adipolin appears to be of particular importance not only in glucose metabolism and the formation of tissue insulin sensitivity but also in preventing cardiovascular disease, and efforts to increase its blood levels in at-risk groups seem justified. One of the few studies evaluating the relationship between neprilysin levels and blood pressure values is that of [PERSON] et al., who found a positive relationship between neprilysin levels and systolic blood pressure values [37]. [PERSON] et al. also found a positive relationship with both systolic and diastolic blood pressure in pregnant women [25]. Our study found a negative relationship with systolic blood pressure but only among those without obesity, but there are no studies with which to compare the results. The role of chemerin in the pathogenesis of the cardiovascular disease, where dyslipidemia is a significant risk factor, is suggested. Many researchers have reported positive correlations between chemerin levels and triglycerideemia and LDL-C [47; 48; 49] and negative correlations with HDL-C [45; 50; 51]. Our study also showed a positive association of chemerin concentration with triglyceride among men. Moreover, high chemerin levels (above median values equal to 46.926 pg/mL) were observed almost four times more frequently in the male population, characterized by elevated triglyceride levels (above 1.7 mmol/L). Chemerin can affect vascular remodeling, proliferation, and migration [52; 53]. Increased adipokine levels are most commonly observed in hypertensive patients [54; 55]. [PERSON] et al. observed a positive correlation between chemerin levels and systolic blood pressure values in obese individuals [30]. Furthermore, one of the blood pressure-lowering drugs, amlodipine, has been shown to decrease plasma chemerin concentrations.