## 3 Results
The SUvr values of the FBB, FMM, and FPN brain PET were extracted from the composite region using PMOD. The extracted SUvr was compared between the normal and patient groups, and a box plot divided by age and sex is shown in Figure 5. The distribution of the SUvr of FPN was significant (\(p<0.01\)) between the amyloid negative- and amyloid-positive groups in all brain cortex regions and is summarized in Table 4. It had the highest \(p\)-value among the three radiopharmaceutical (FBB, FMM, and FPN). The FBB, FMM, and FPN brain PET data were classified based on the age at which the number of comparison subjects was similarly distributed. There was no significant difference in the classification ability according to age distribution. In the normal group, an SUvr over 70 years of age was found to have a slightly higher distribution; however, only a small difference was observed. There was no significant difference in the discrimination ability according to sex. In the distribution of the normal group, SUvr in the female group was slightly higher in the FBB group and slightly lower in the FMM and FPN groups; however, no significant difference was observed. The distribution of the brain PET SUvr in the FBB and FMM groups was similar, and it was more widely distributed than FPN in the patient group. For the three radiopharmaceutical, it was observed that the mean value and \begin{table}
\begin{tabular}{c c c c c c c c c} \hline \hline  & \multicolumn{4}{c}{**FMM-FS \({}^{*}\)**} & \multicolumn{4}{c}{**FMM-PMOD**} & \multirow{2}{*}{**R**} \\ \cline{2-2} \cline{5-10}  & **Sensitivity** & **Specificity** & **Threshold** & \(p\)**-Value** & **Sensitivity** & **Specificity** & **Threshold** & \(p\)**-Value** & \\ \hline FC & 97.37 & 100.00 & 1.268 & \(1.33\times 10^{-17}\) & 100.00 & 95.00 & 1.242 & \(5.04\times 10^{-17}\) & 0.98 \\ LTC & 94.74 & 95.00 & 1.264 & \(5.33\times 10^{-15}\) & 97.37 & 97.50 & 1.258 & \(9.00\times 10^{-15}\) & 0.98 \\ MTC & 26.32 & 92.50 & 1.399 & \(3.18\times 10^{-1}\) & 97.37 & 20.00 & 1.093 & \(2.38\times 10^{-1}\) & 0.94 \\ PC & 97.37 & 97.50 & 1.283 & \(1.37\times 10^{-15}\) & 97.37 & 100.00 & 1.282 & \(9.45\times 10^{-18}\) & 0.95 \\ OC & 84.21 & 100.00 & 1.347 & \(1.38\times 10^{-13}\) & 84.21 & 97.50 & 1.353 & \(2.36\times 10^{-12}\) & 0.96 \\ GCA & 97.37 & 90.00 & 1.323 & \(6.68\times 10^{-17}\) & 92.11 & 97.50 & 1.395 & \(3.63\times 10^{-16}\) & 0.99 \\ GCP & 100.00 & 95.00 & 1.391 & \(4.94\times 10^{-19}\) & 97.37 & 100.00 & 1.598 & \(1.30\times 10^{-17}\) & 0.97 \\ CN & 84.21 & 95.00 & 1.27 & \(9.15\times 10^{-12}\) & 92.11 & 95.00 & 1.392 & \(2.43\times 10^{-12}\) & 0.74 \\ PUT & 89.47 & 82.50 & 1.704 & \(8.71\times 10^{-12}\) & 97.37 & 85.00 & 1.256 & \(7.65\times 10^{-13}\) & 0.80 \\ THA & 89.47 & 70.00 & 1.725 & \(1.36\times 10^{-7}\) & 97.37 & 95.00 & 1.178 & \(8.85\times 10^{-19}\) & 0.60 \\ PQ & 94.74 & 100.00 & 1.391 & \(2.05\times 10^{-18}\) & 97.37 & 100.00 & 1.332 & \(2.51\times 10^{-19}\) & 0.99 \\ Composite & 97.37 & 97.50 & 1.272 & \(4.90\times 10^{-17}\) & 97.37 & 100.00 & 1.285 & \(5.60\times 10^{-17}\) & 0.98 \\ \hline \hline \end{tabular} \({}^{*}\) FS: FreeSurfer.  
\end{table} 
Table 4: Sensitivity, specificity, the threshold of SUvr, \(p\)-value in t-test, and the correlation coefficient (R) calculated using PMOD and FreeSurfer algorithms in FMM brain PET SUvr. Each value was calculated for FC, LTC, MTC, PC, OC, GCA, GCP, PQ, and composite regions.