# Anti-Breast Cancer Activity of Essential Oil:
## 3 Result
### Bioactivity of Essential Oils as Anti-Breast Cancer Agents
\begin{table}
\begin{tabular}{c c c c c} \hline \hline
**No** & **Plant Name** & **Compounds** & **Methods** & **Activities** & **Ref.** \\ \hline
25 & _Murraya keenigii_ & Sesquiterpenes & MCF-7 cells & Essential oil in particular exhibits strong antibacterial and cytotoxic effects with a dose-dependent trend (\(\leq\)5.0 \(\mathrm{\SIUnitSymbolMicro g}\)/mL). & [114] \\ \hline
26 & _Cedrelopsis grevei_ & Sesquiterpenes & MCF-7 cells & The main constituents are (E)-\(\beta\)-farnesene (27.61\%), \(\delta\)-cadience (14.48\%), \(\alpha\)-copaene (7.65\%), and \(\beta\)-elemene (6.96\%). Grevei essential oil is active against MCF-7 cells (IC\({}_{50}\) = 21.5 mg/L). & [115] \\ \hline
27 & _Asteraceae family_ & Sesquiterpenes & MCF-7 and MDA-MB-468 cells & _Britannin_ can induce apoptosis in MCF-7 and MDA-MB-468 cells. Western blot analysis shows that Bcl-2 expression markedly decreased in response to _Britannin_ treatment, whereas Bax protein expression increased, which is positively correlated with increased p53 expression. & \\ \hline
28 & _Tanactum_ & Sesquiterpenes & In vivo (white rats) & Histopathological examination showed that TPHE significantly suppressed the carcinogenic effect of LA7 tumor cells. Tumor sections from TPHE-treated mice showed a significantly decreased expression of Ki67 and PCNA compared to the control group. & [117] \\ \hline
29 & _Gailardin, was_ & & Gaillardin is able to induce apoptosis in the breast cancer cell lines of MCF-7 and MDA-MB-468 and determine the mechanism underlying their anticancer effects. Induction of apoptosis with Gaillardin treatment is confirmed by annexin V-FITC/PI staining, and activation of caspase-3, -6, and -9. & \\ \hline
30 & _Opoponax_ (_Commiphora_ & Sesquiterpenes & In vivo (white rats) & Opoponax essential oil shows specific cytotoxicity for mammary tumor cells of humans and mice in vitro and in vivo, and this warrants further investigation into the use of \(\beta\)-bisabolene in medicine. & [103] \\ \hline
31 & _Eupatorium_ & Sesquiterpenes & MDA-MB-231 cells (TNBC) & Inhibits migration, invasion, and motility of MDA-MB-231 cells in a concentration-dependent manner by invasion and apoptosis. & [119] \\ \hline
32 & _Eupatorium_ & Sesquiterpenes & MDA-MB-468 cells (TNBC) & EO-induced cytotoxicity is mediated by the induction of apoptosis. & [120] \\ \hline
33 & _Ulva fasciata_ & Sesquiterpenes & MDA-MB 231 cells (TNBC) & Computational study shows the interaction of gavi-2-en-10\(\alpha\)-ol with the Asp855 residue of the EGFR kinase domain in the active conformation. All these results suggest the anticancer potential of guai-2-en-10\(\alpha\)-ol via the EGFR/PI3K/Akt pathway. & [121] \\ \hline
34 & Plants such as _Inula helminth_ & Sesquiterpenes & MDA-MB 231 cells (TNBC) & ALA can inhibit the proliferation, motility, migration, and tube formation of human umbilical vein endothelial cells. ALA also inhibits angiogenesis at the chorioallantoic membrane of chicken embryos and slows the growth of the xenograft of human breast cancer of MDA-MB-231. & [61] \\ \hline \hline \end{tabular}
\end{table} 
Table 1: _Cont._