# Structure-Function Coupling Reveals Seizure Onset Connectivity Patterns
## 3 Results
### Structure-Function Coupling  
The structure-function coupling observed in the nine patients revealed three distinct groups with the following features. The first group (Patients 1-3, Figure 2a) had the highest laterality scores (L = 3), with coupled electrode pairs that consistently overlapped with the seizure onset zone. The second group (Patients 4-6, Figure 2b) had less well-lateralised seizures (L = 2-3), and the coupled electrode pairs overlapped with the onset side but not the exact zone. In Patient 4, only two out of three seizures were highly lateralised (L = 3) while the third was not (L = 2), and the electrode pair (PZ-O2) that did not overlap with the exact seizure onset zone was observed on the poorly lateralised seizure. Patient 4 also had three single electrodes from highly connected MRI and EEG pairs that overlapped inside the seizure onset zone (shown in heatmaps in Figure A1). Patients 5 and 6 were less well lateralised, and highly coupled electrode pairs were present both within and outside the seizure onset zone. In Patient 6, the electrode pair T3-C3 overlapped with the expected onset zone of the one poorly lateralised seizure. The third group (Patients 7-9, Figure 2c) were considered non-lateralised for most of their seizures. These patients generally displayed highly coupled electrode pairs that were inconsistent with the expected onset zone or had only a single overlapping MRI and EEG electrode rather than a pair (Patient 7). Figure 2 contains a condensed interpretation of the detailed results for each patient, shown in Appendix A. The overlapping electrode pairs with MRI z-scores (>2) and EEG z-scores (>1.8) are displayed. The most common seizure onset zone for each patient is also displayed.  
\begin{table}
\begin{tabular}{l c c c c c c c c c} \hline \hline
**Subject No.** & **1** & **2** & **3** & **4** & **5** & **6** & **7** & **8** & **9** \\ \hline L. rostralamericionguilate & FP1 & FP1 & FP1 & FZ & F3 & FP1 & FZ & FP1 & FP1 \\ R. rostralamericionguilate & FP2 & FP2 & FP2 & FZ & FP2 & FP2 & FZ & F4 & FP2 \\ L. parsopercularis & F3 & F7 & F7 & F3 & F7 & F7 & T3 & F7 & F3 \\ L. ranspecularis & F8 & F8 & F8 & F8 & F8 & F8 & F4 & T4 & F4 \\ L. insula & T3 & F7 & T3 & F7 & T3 & T3 & T3 & T3 & T3 \\ R. insula & T4 & F8 & F8 & F8 & F8 & T4 & C4 & T4 & T4 \\ L. inferiortemporal & T5 & T5 & T5 & T5 & T3 & T5 & T5 & T3 & T5 \\ R. inferiortemporal & T6 & T4 & T6 & T6 & T4 & T6 & T6 & T4 & T6 \\ L. lateralorbitofrontal & FP1 & F7 & F7 & F7 & F7 & F7 & F7 & F7 & F7 \\ R. lateralorbitofrontal & FP2 & F8 & F8 & F8 & F8 & F8 & F4 & F8 & F2 \\ L. cuneus & O1 & O1 & O1 & O1 & O1 & O1 & PZ & O1 & O1 \\ R. cuneus & O2 & O2 & O2 & PZ & O2 & PZ & O2 & PZ & O2 \\ L. transversetemporal & T3 & T3 & T3 & C3 & T3 & T3 & T3 & T3 & T3 \\ R. transversetemporal & T4 & T4 & T4 & C4 & T4 & T4 & T4 & T4 \\ L. caudalantiercingulate & FZ & FZ & FZ & FZ & F3 & FZ & F3 & FZ \\ R. caudalantiercingulate & FZ & FZ & FZ & FZ & FZ & FZ & F4 & FZ \\ L. isthmuscingulate & FZ & PZ & PZ & CZ & PZ & PZ & PZ & PZ & PZ \\ R. isthmuscingulate & PZ & PZ & PZ & CZ & PZ & PZ & PZ & PZ & PZ \\ R. bankssts & T6 & T6 & T4 & T6 & T4 & T6 & T6 & T6 & T6 \\ R. superiorofrontal & FZ & FZ & FZ & FZ & FZ & FZ & CZ & FZ \\ R. caudalmiddle frontal & C4 & C4 & C4 & F4 & C4 & C4 & C4 & C4 & C4 \\ R. temporpolpolpo & F8 & F8 & F8 & F8 & F8 & F8 & F8 & T4 & F8 \\ L. suparararginal & C3 & P3 & C3 & C3 & C3 & C3 & C3 & C3 \\ L. superiorar parietal & P3 & PZ & PZ & PZ & PZ & PZ & PZ & PZ & PZ \\ \hline \hline \end{tabular}
\end{table}
Table 2: Between patient region variance in the region to electrode mapping.