## 3 Results
muricata_ leaf ethanol extract: (**a**) anonaine; (**b**) chlorogenic acid; (**c**) colaurine; (**d**) isolaureline; (**e**) isoquercetin; (**f**) kaempferol, (**g**) loliolide; (**h**) norcrydine; (**i**) quercetin; (**j**) reticuline; (**k**) rutin; (**l**) xylopine. Figure 4: Histopathology profiles: the renal glomerular diameters, the Bowman’s space width, the renal proximal convoluted tubule and the renal glomerular tubularization of the left kidney. All figures were prepared by Hematoxylin and Eosin (H&E) staining at 400\(\times\) magnification in each group of: (**a**). Negative control; (**b**). Positive control; (**c**). Low-dose ethanol extract of soursop leaf (LD-SLEE) group 150 mg/kg BW; (**d**). Medium-dose ethanol extract of soursop leaf (MD-SLEE) group 300 mg/kg BW; (**e**). High-dose ethanol extract of soursop leaf (HD-SLEE) group 600 mg/kg BW. An analysis using [PERSON]'s test of the variable of the thickness of proximal convoluted tubule of left kidney showed a \(p\)-value of 0.175 (\(p>0.05\)). Thus, the data variants in the treatment group were homogeneous. On the other hand, [PERSON]'s test of the thickness of proximal convoluted tubule of right kidney variable had a \(p\)-value of 0.001 (\(p<0.05\)) in each treatment group. It was confirmed that the data variants of proximal convoluted tubule's thickness were significantly different from the thickness of proximal convoluted tubule of right kidney. The data variant analysis of left renal glomerular tubularization variable using [PERSON]'s test showed a \(p\)-value was 0.071 (\(p>0.05\)). It indicated that the data variant of each treatment group was homogeneous. Moreover, the data variant analysis of right renal glomerular tubularization variable using Kruskal-Wallis test showed a \(p\)-value was 0.085 (\(p>0.05\)), performing no significant difference among the treatment groups. Therefore, [PERSON] post hoc test was unnecessary. Statistical analysis using the one-way ANOVA test was carried out to determine the optimal dose of soursop leaf ethanol extract (_Anmonia muricata_) against renal histopathological changes, particularly the thickness in right Bowman's space width and left renal glomerular diameter of alloxan-induced mice. The one-way ANOVA statistical analysis of [PERSON]'s space width of right kidney and glomerular diameter of left kidney is shown in Figure 5.  
Based on the one-way ANOVA test results, the thickness of left renal had a \(p\)-value of 0.947 (\(p>0.05\)). It exhibited that the mean of thickness of left kidney glomerulus between treatment groups was not significantly different. The one-way ANOVA test for the thickness of [PERSON]'s space width of right kidney had a \(p\)-value of 0.025 (\(p<0.05\)). Furthermore, Bonferroni post hoc test was carried out, and there was a significant difference between the high-dose SLEE (HD-SLEE) group and the negative control group (Figure 2). Therefore, it was concluded that the mean of [PERSON]'s space width of right kidney in each group was significantly different. The one-way ANOVA test from the thickness of proximal convoluted tubule of left kidney variable showed that a \(p\)-value was 0.119 (\(p>0.05\)) and exhibited no significant difference. In contrast, the results of one-way ANOVA test for the thickness of proximal convoluted tubule of right kidney had a \(p\)-value of 0.239 (\(p>0.05\)). Thus, it can be suggested that the mean of the thickness of proximal convoluted tubule of right kidney in each group was not significantly different. The results of the data distribution that were normally distributed and the variants of the homogeneous data in each treatment group had fulfilled the one-way ANOVA test requirements. Left renal glomerular tubularization variable showed a \(p\)-value of 0.001 (\(p<0.05\)), which was significantly different.