## 3 Results
### Diagnostic Performance of PET/CT and BMB in Determining BMI
#### 3.4.2 Diagnostic Performance of [18]FDG PET/CT and BMB in Determining BMI in Subtypes Lymphoma  
According to the studies included in this systematic review, the overall sensitivity, specificity, PPV, NPV of [18]FDG PET/CT and BMB were analyzed for different subtypes of lymphoma cases. For DLBCL, across the eligible studies, the sensitivity of [18]FDG PET/CT in determining BMI (n = 2336; studies = 20) ranged from 14.10% to 100% (median = 77.40%), specificity ranged from 54% to 100% (median = 91.65%), PPV ranged from 29.00% to 100% (median = 63.60%), and NPV ranged from 81.00% to 100%  
\begin{table}
\begin{tabular}{c c c c c c c c c c} \hline \hline  & & \multicolumn{3}{c}{**Sensitivity (Median)**} & \multicolumn{3}{c}{**Specificity (Median)**} & \multicolumn{3}{c}{**PPV (Median)**} & \multicolumn{3}{c}{**PPV (Median)**} \\ \hline
**No.** & **Disease** & **[18]**FFDG** & **BMB** & **[18]**FFDG** & **BMB** & **[18]**FFDG** & **BMB** & **[18]**FFDG** & **BMB** \\
**Studies** & **Disease** & **PET/CT** & **BMB** & **PET/CT** & **BMB** & **PET/CT** & **BMB** \\ \hline
20 & DLBCL & 77.40\% & 47.00\% & 91.65\% & 100.00\% & 63.60\% & 100.00\% & 97.00\% & 80.00\% \\
9 & FL & 60.00\% & 81.00\% & 81.00\% & NR & 59.50\% & NR & 79.65\% & 85.55\% \\
4 & MCL & 60.34\% & 95.20\% & 86.67\% & NR & 87.50\% & NR & 55.60\% & 71.65\% \\
2 & BL & 58.30\% & 66.70\% & NR & NR & NR & 77.50\% & 73\% \\
1 & PMBCL & 33.30\% & 66.70\% & NR & NR & NR & 83.30\% & 90.90\% \\
1 & PTCL & 89.30\% & 60.70\% & 100\% & 100\% & 100\% & 100\% & 94.80\% & 83.30\% \\
41 & NHL & 73.30\% & 56.00\% & 89.70\% & 100.00\% & 63.30\% & 100.00\% & 92.45\% & 83.65\% \\
12 & Indolent & 58.50\% & 93.70\% & 85.10\% & 100.00\% & 60.00\% & 100.00\% & 78.30\% & 95.55\% \\
24 & Aggressive & 77.00\% & 57.90\% & 93.80\% & 100.00\% & 63.60\% & 100.00\% & 97.00\% & 84.42\% \\ \hline \hline \end{tabular}
\end{table}
Table 5: Diagnostic performance of [18]FDG PET/CT and BMB in determining BMI in NHL cases and subtypes of NHL lymphoma cases.  
(median = 97.00%). For DLBCL, the sensitivity of BMB in determining BMI ranged from 24.00% to 68.80% (median = 47.00%), specificity was 100%, PPV was 100% and NPV ranged from 63.20% to 91.10% (median = 80.00%).  
For the subtype FL, the sensitivity of [18F]FDG PET/CT in determining BMI (n = 1059; studies = 9) ranged from 0% to 86.00% (median = 60.00%), specificity ranged from 72.70% to 88.00% (median =81.00%), PPV ranged from 0% to 61.10% (median = 59.50%), and NPV ranged from 63.00% to 89.70% (median = 79.65%). Compared to BMB, for the subtype FL the sensitivity of [18F]FDG PET/CT ranged from 0% to 81.00% (median = 58.50%) while for BMB ranged from 60.00% to 93.70% (median = 81.00%).  
For MCL cases, the sensitivity and NPV of [18F]FDG PET/CT in determining BMI (n = 97; studies = 4) ranged from 28.60% to 100% (median = 60.34%) and 28.60% to 76.47% (median = 55.60%), respectively. For BMB, the sensitivity and NPV ranged from 42.90% to 100% (median = 95.20%) and 55.60% to 87.70% (median = 71.65%), respectively. For BL cases, the sensitivity of [18F]FDG PET/CT in determining BMI (n = 21; studies = 2) ranged from 33.30% to 83.30% whereas for the BMB it was 66.70%. The NPV for [18F]FDG PET/CT ranged from 75.00% to 80.00% and the BMB ranged from 60.00% to 88.90%. The specificity and PPV were not reported in any of the studies.