## 1 _Eiditorial_
Using different optimized extraction approaches may enable plant extracts with more defined, stronger antimicrobial activity to be obtained, compared to the ones obtained conventionally. Supercritical fluid extraction (SFE) is one of the alternative methods to conventional systems that in the last decade has gained acceptance in the extraction of valuable substances. In order to obtain the best qualitative and quantitative values of bioactive compounds in the extracts,the choosing of the extraction techniques must be followed by the right choice of the solvents and extraction conditions applied. [PERSON] et al. 2022 [5] investigated _Glechoma hederacea_ var. _longituba_ plant extracts obtained by SFE with carbon dioxide (SC-CO2), using methanol as a co-solvent. According to the obtained results, SC-CO2 extracts of _Glechoma_ are a promising source of bioactive constituents that can be beneficial in a sustainable manner, acting as natural antioxidants and antibacterial agents. Nevertheless, the biological activity of _G. hederacea_ extracts obtained under different conditions of the process was affected by the increasing temperature of the process. The results indicate that the obtained _Glechoma_ extracts are characterized by high total phenolic content (TPC) values, which differ depending on the extraction conditions. The high TPC values correlate with high antioxidant properties, as well as antimicrobial (excluding filamentous fungi) and antibiofilm activity (the prevention of biofilm formation) [5]. The research of [PERSON] et al. 2022 [6] included optimization of the ultrasound-assisted extraction (UAE) of phenolic compounds from kiwi peel, contributing to this fruit waste valorization. This low-cost raw material was determined by its promising bioactive properties, among which antioxidant and antimicrobial effects, and no toxicity to Vero cells were observed. Optimization of the UAE coupled with the response surface methodology (RSM) included different process parameters, including time, ultrasonic power and ethanol concentration. The extraction efficiency was determined gravimetrically and the contents of phenolic compounds identified by HPLC-DAD-ESI/MSn were also used in the optimization. In turn, the polynomial models were fitted to the experimental data and used to determine the optimal conditions. The sonication of the sample under appropriate conditions allowed for the experimental validation of the predictive model. The studies are consistent with the current trends concerning the development of natural ingredients (such as food preservatives) from waste and also the resource-use efficiency and circular bioeconomy [6]. Despite the fact that the Special Issue has been closed, the research concerning the discovery of new sufficient antimicrobial substances, characterized by broad biological properties, is the matter of constant ongoing research. As the newly developed approaches of extraction are investigated, new opportunities for obtaining plant-derived antimicrobials are observed. Furthermore, the application for food products and agriculture of such substances enables the exclusion of their chemical equivalents. Sustainable recovery seems to be an important trend in view of the need to care for the environment. Novel approaches of obtaining antimicrobial substances should be more environmentally friendly and pollution-free; therefore, there is a great need to develop and optimize such methods. The authors declare no conflict of interest.