## 3 Materials and Methods
### Materials
1-(2,5,8,11,14,17,20-heptaoxahexacosan-26-yl)-3-phenylurea (UBD-1)  
To a solution of phenyl isocyanate (52.9 mg, 0.44 mmol) in 1 mL toluene, a solution of **Eg\({}_{6}\)C\({}_{6}\)NH\({}_{2}\)** (200 mg, 0.49 mmol) in 1 mL CH\({}_{2}\)Cl\({}_{2}\) was added dropwise while stirring in an ice bath. The mixture was stirred overnight, allowing it to reach room temperature. The resulting solution was evaporated and chromatographed on silica gel with CH\({}_{2}\)Cl\({}_{2}\)/MeOH (10:1) as the eluent to afford 189 mg of **mono-PhC6** as a colorless oil in 82.6% yield. IR (neat on NaCl) 3348, 2931, 2864, 1696, 1668, 1597, 1553, 1500, 1441, 1350, 1311, 1238, 1109, 949, 850 cm\({}^{-1}\). \({}^{1}\)H NMR (DMSO-\(d_{6}\), 500 MHz) \(\delta\) 8.35 (\(s\), 1H), 7.38-7.37 (\(dd\), \(J\) = 8.7, 1.2 Hz, 2H), 7.21-7.18 (\(t\), \(J\) = 8.0 Hz, 2H), 6.89-6.85 (\(t\), \(J\) = 8.5 Hz, 1H), 6.09-6.07 (\(t\), \(J\) = 5.6 Hz, 1H), 3.50-3.49 (\(m\), 20H), 3.46-3.45 (\(m\), 2H), 3.43-3.41 (\(m\), 2H), 3.39-3.36 (\(t\), \(J\) = 6.6 Hz, 2H), 3.23 (\(s\), 3H), 3.08-3.03 (\(q\), \(J\) = 12.7, 6.9 Hz, 2H), 1.51-1.48 (\(m\), 2H), 1.43-1.40 (\(m\), 2H), 1.30-1.29 (\(m\), 4H). \({}^{13}\)C NMR (DMSO-\(d_{6}\), 126 MHz) \(\delta\) 155.21, 140.61, 128.62, 120.90, 117.56, 71-(2,5,8,11,14,17,20-heptaoxaheptacosan-27-yl)-3-phenylurea (UBD-2)  
**UBD-2** was prepared in a manner similar to that described for **mono-PhC6**, using **Eg\({}_{6}\)C\({}_{7}\)NH\({}_{2}\)** instead of **Eg\({}_{6}\)C\({}_{6}\)NH\({}_{2}\)**. The reaction yield was 91.5%. IR (neat on NaCl) 3306, 2929, 2864, 1686, 1597, 1551, 1500, 1442, 1351, 1313, 1239, 1106, 952, 849 cm\({}^{-1}\). \({}^{1}\)H NMR (DMSO-\(d_{6}\), 500 MHz) \(\delta\) 8.36 (s, 1H), 7.37-7.35 (\(dd\), \(J\) = 8.7, 1.2 Hz, 2H), 7.20-7.18 (\(t\), \(J\) = 4.3 Hz, 2H), 6.87-6.86 (\(t\), \(J\) = 1.0 Hz, 1H), 6.10-6.08 (\(t\), \(J\) = 5.6 Hz, 1H), 3.50-3.49 (\(m\), 24H), 3.47-3.45 (\(m\), 2H), 3.43-3.41 (\(m\), 2H), 3.38-3.34 (\(t\), \(J\) = 10.3 Hz, 2H), 3.23 (s, 3H), 3.08-3.04 (\(q\), \(J\) = 12.7, 6.8 Hz, 2H), 1.50-1.47 (\(m\), 2H), 1.43-1.40 (\(m\), 2H), 1.28 (\(m\), 6H). \({}^{13}\)C NMR (DMSO, 126 MHz) \(\delta\) 155.23, 140.60, 128.64, 120.93, 117.58, 71.29, 70.32, 69.81, 69.60, 69.50, 58.07, 39.25, 29.72, 29.17, 28.61, 26.37, 25.66. HRMS (ESI) Calcd. for C\({}_{27}\)H\({}_{48}\)N\({}_{2}\)NaO\({}_{8}\) [M + Na]\({}^{+}\): _m/z_ 537.3308, Found: 551.3323. Anal. Calcd. for C\({}_{27}\)H\({}_{48}\)N\({}_{2}\)O\({}_{8}\): C, 61.34; H, 9.15; N, 5.30, Found: C, 61.33; H, 9.26; N, 5.44. 1-(2,5,8,11,14,17,20-heptaoxaoctacosan-28-yl)-3-phenylurea (UBD-3)  
**UBD-3** was prepared in a manner similar to that described for **mono-PhC6**, using **Eg\({}_{6}\)C\({}_{8}\)NH\({}_{2}\)** instead of **Eg\({}_{6}\)C\({}_{6}\)NH\({}_{2}\)**. The reaction yield was 45.6%. IR (neat on KBr) 3303, 2927, 2860, 1685, 1597, 1551, 1450, 1441, 1351, 1312, 1236, 1106, 951, 849 cm\({}^{-1}\). \({}^{1}\)H NMR (DMSO-\(d_{6}\), 500 MHz) \(\delta\) 8.35 (s, 1H), 7.37-7.35 (\(dd\), \(J\) = 8.6, 1.0 Hz, 2H), 7.21-7.18 (\(t\), \(J\) = 7.9 Hz, 2H), 6.88-6.85 (\(t\), \(J\) = 7.9 Hz, 1H), 6.09-6.07 (\(t\), \(J\) = 5.6 Hz, 1H), 3.50-3.46 (\(m\), 2H), 3.43-3.41 (\(m\), 2H), 3.38-3.36 (\(t\), \(J\) = 6.6 Hz, 2H), 3.23 (s, 3H), 3.08-3.04 (\(q\), \(J\) = 12.8, 6.8 Hz, 2H), 1.50-1.46 (\(m\), 2H), 1.42-1.40 (\(m\), 2H), 1.27 (\(m\), 8H). \({}^{13}\)C NMR (DMSO-\(d_{6}\), 126 MHz) \(\delta\) 155.22, 140.60, 128.63, 120.92, 117.57, 71.30, 70.33, 69.81, 69.60, 69.50, 58.07, 39.25, 29.76, 29.22, 28.88, 28.79, 26.36, 25.64. HRMS (ESI) Calcd. for C\({}_{27}\)H\({}_{48}\)N\({}_{2}\)NaO\({}_{8}\) [M + Na]\({}^{+}\): _m/z_ 565.3465, Found: 565.3577. Anal. Calcd. for C\({}_{28}\)H\({}_{50}\)N\({}_{2}\)O\({}_{8}\): C, 61.97; H, 9.29; N, 5.16, Found: C, 61.68; H, 9.43; N, 5.04.