For the improvement of eye-hand coordination tasks, different exercises and activities could be performed. Among these, the activities that make use of an unstable platform, such as a wobble board, and the manipulation of small objects, such as gaming, are considered useful strategies to increase fine motor skills and eye-hand coordination [13]. Eye-hand coordination uses the eyes to direct attention and the hands to execute and accomplish a task [14], of which a fundamental component is manual dexterity. Manual dexterity is defined as the ability to skillfully use hands and fingers to perform intricate tasks that demand precision and coordination, involving the precise manipulation of objects and the fine coordination of manual movements [15]. It is characterized as precise, diverse, and flexible behavior that requires the coordination of many segments and can be expanded through learning. Influenced by hand dominance, it plays a crucial role in everyday life [16]. In fact, the preferred hand is usually defined as the hand that is most efficient to perform specific manual dexterity tasks (e.g., writing, manipulating objects or tools, etc.). The difference in skills due to lateral dominance is defined as inter-limb imbalance or inter-limb asymmetry [17]. When this asymmetry is attributed to the tremor and the difference in tremor between the limbs, it could be defined as the inter-limb asymmetry of tremors [17]. Several studies suggest that regular physical exercise may improve a variety of physiological and psychological factors in hand tremors [18; 19]. In fact, more researchers [10; 20; 21; 22] have focused their work on the effect of training interventions on the hand tremor. Studies on healthy individuals have reported an improvement in steadiness (a general term used to indicate a reduction in physiological tremor or increased precision in executing tasks requiring a high degree of motor control) as a result of structured interventions involving a physical task, such as yoga, functional and manual tasks, and light-load training. Exercise in general is defined as a protective factor of neurological capacity and cognitive impairment. Studies have shown that an increased amount of exercise in the general population leads to improved cognition, highlighting the neuroprotective benefits of physical activity [23; 24]. One of the most utilized types of exercise in programs for the management of hand tremors is resistance training [25], which may provide considerable benefit to participants with a hand tremor, especially those who experience greater tremor intensity in one limb compared to the other. A previous study highlighted how a 6-week high-load resistance training program that separately exercised muscles of each forearm and upper arm, with the goal of increasing overall upper-limb strength, had a notable effect on hand tremors [22]. Although the role of exercise and physical activity is traditionally focused on strength and resistance training to improve motor control and reduce tremors in individuals with a physiological hand tremor [21; 22; 26], there is less evidence of the role of eye-hand coordination exercise with an unstable platform to address the inter-limb asymmetry of tremors. Inter-limb asymmetry is an important aspect to consider in physical health and exercise programs. It could have a negative impact on sporting performance and be associated with a high incidence of injuries and difficulty in carrying out daily activities [27; 28]. The strongest limb may sustain excessive stress compared to the other one, resulting in unequal force absorption or a loss of frontal plane stability. Since eye-hand coordination has a significant impact on sporting performance and daily activities [28], it would be interesting to investigate the impact on hand tremors and inter-limb asymmetry. We hypothesized that participants could show a decrease in hand tremor magnitude after eye-hand coordination exercises in their non-dominant limb, reflecting the acute impact of hand exercises on inter-limb asymmetry.