## 1 Introduction  
Achieving success in endodontic therapy is contingent upon accurately utilizing devices and materials throughout cleansing and filling the root canal system. The purpose of the obturation phase is to create a completely sealed barrier throughout the endodontic system. This will inhibit the entry of microorganisms into the root canal system via the foramen, coronal, and periapical tissue fluids. Additionally, it will serve as a preventive measure against apical periodontitis lesions. Globally, fifty percent of adults possess at least one tooth affected by apical periodontitis [1]. Increasing evidence suggests that the bacteremia and low-grade systemic inflammation associated with chronic apical periodontitis may adversely affect general health, perhaps contributing to cardiovascular diseases, adverse pregnancy outcomes, and diabetes, which complicates blood sugar regulation [2]. Moreover, compelling research indicates that effective root canal therapy enhances general health by reducing the inflammatory load [2]. Maintaining proper dental hygiene, mainly through the regular removal of dental plaque, is essential for preventing microbial infiltration that may result in complications like apical periodontitis [3]. Root canal obturation is commonly carried out by employing a core substance, typically gutta-percha, together with an endodontic sealer. [PERSON] (1981) states that an optimal endodontic sealer must possess several attributes to ensure a successful endodontic treatment [4; 5; 6]. These include biocompatibility, antibacterial properties, dimensional stability, dentin and core material adherence, radiopacity, and flowability. It is crucial to recognize that, although [PERSON]'s ideal sealer offers a structure for desirable characteristics [6], no sealer can presently encompass all of these traits. Sealers are often selected by clinicians depending on the individual requirements of each case, taking into account aspects like biocompatibility, handling characteristics, and therapeutic efficacy. Previously, epoxy resin-based sealers were the preferred choice for sealants in endodontics. The interaction between hexamethylene tetramine and bis-phenol resin monomer undergoes ring-opening polymerization, resulting in their solidification. However, not all endodontic sealers are compatible with the tissues at the apex of the tooth [7]. One example is AH26 (Dentsply Sirona, York, PA, USA), which is an epoxy resin sealer that utilizes hexamethylene-tetramine (methenamine) for the process of polymerization [8]. One significant drawback of methanamine is its tendency to emit formaldehyde during solidification. Consequently, dentists tend to favor alternative forms of sealants [9]. In recent decades, there has been substantial growth in study within materials science and engineering, specifically focusing on biocompatible materials, often known as biomaterials, replacing materials with cytotoxic potential [10]. The primary benefits of these materials include their ability to interact well with living organisms, their capacity to promote biological processes, and their strong ability to combat microbial growth [4]. Due to these specific criteria, dentists are progressively utilizing bioceramic sealants. Meanwhile, they do not experience any size-reduction and retain their volume for a prolonged duration [4; 5]. Thus, it is feasible to utilize bioceramic sealers in greater quantities without augmenting the quantity of gutta-percha within the root canal. It is advisable to utilize hydraulic calcium silicate-based sealers in conjunction with a single-cone obturation procedure. The gutta-percha cone increases hydraulic pressure in the root canal and pushes the sealer into isthmuses, anomalies, and dental tubules [11; 12; 13]. This obturation technique is readily adaptable, even for doctors with less expertise. Research has demonstrated that bioceramic sealers have a heightened capacity to promote collagen synthesis, hence assisting in tissue regeneration [14].