## 3 Results
### Mechanism of Action at Gene and Protein Level
\begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**UniGEne** & **RefSeq** & **Symbol** & **Description** & **Fold** & **SD** \\ \hline \multicolumn{5}{c}{Genes Up-Regulated by Pheophorbide \(a\) Treatment plus Photo-Activation} \\ \hline Hs.632469 & NM\_020387 & RAB25 & RAB25, member RAS oncogene family & 3.84 & 0.00082 \\ Hs.241570 & NM\_000594 & TNF & Tumor necrosis factor & 3.06 & 0.00033 \\ Hs.744830 & NM\_000125 & ESR1 & Estrogen receptor 1 & 2.44 & 0.00021 \\ Hs.643440 & NM\_002361 & MAG & Myelin associated glycoprotein & 2.38 & 0.00017 \\ Hs.32949 & NM\_005218 & DEFB1 & Defensin, beta 1 & 2.20 & 0.00019 \\ Hs.2007 & NM\_000639 & FASLG & Fas ligand (TNF superfamily, member 6) & 2.02 & 0.00019 \\ \hline \multicolumn{5}{c}{Genes down-regulated by Pheophorbide \(a\) treatment plus photo-activation} \\ \hline Hs.434980 & NM\_000484 & APP & Amyloid beta (A4) precursor protein & -3.48 & 0.10040 \\ Hs.189782 & NM\_018202 & TMEM57 & Transmembrane protein 57 & -2.80 & 0.00419 \\ Hs.1437 & NM\_000152 & GAA & Glucosidase, alpha; acid & -2.47 & 0.00531 \\ Hs.269027 & NM\_014568 & GALNT5 & UDP-N-acetyl-alpha-D-galactosamine:polypeptide & -2.41 & 0.00010 \\ Hs.171844 & NM\_006505 & PVR & Poliovirus receptor & -2.07 & 0.02680 \\ \hline \multicolumn{5}{c}{Genes up-regulated by Fraction E plus photo-activation} \\ \hline Hs.744830 & NM\_000125 & ESR1 & Estrogen receptor 1 & 5.59 & 0.00049 \\ Hs.472860 & NM\_001250 & CD40 & CD40 molecule, TNF receptor superfamily member 5 & 4.17 & 0.00028 \\ Hs.241570 & NM\_000594 & TNF & Tumor necrosis factor & 3.75 & 0.00040 \\ Hs.592244 & NM\_000074 & CD40 LG & CD40 ligand & 2.30 & 0.00019 \\ Hs.32949 & NM\_005218 & DEFB1 & Defensin, beta 1 & 2.30 & 0.00020 \\ Hs.87236 & NM\_012188 & FOXI 1 & Forkhead box I1 & 2.30 & 0.00019 \\ Hs.856 & NM\_000619 & IFNG & Interferon, gamma & 2.30 & 0.00021 \\ Hs.700350 & NM\_000207 & INS & Insulin & 2.30 & 0.00020 \\ Hs.519680 & NM\_01145805 & IRGM & Immunity-related GTPase family, M & 2.30 & 0.00090 \\ Hs.592068 & NM\_020655 & IPH3 & Junctionbilin 3 & 2.30 & 0.00022 \\ Hs.553833 & NM\_001004467 & ORI0J3 & Olfactory receptor, family 10, subfamily J, member 3 & 2.30 & 0.00020 \\ Hs.442337 & NM\_176823 & S100A7A & S100 calcium-binding protein A7A & 2.30 & 0.00020 \\ Hs.632469 & NM\_020387 & RAB25 & RAB25, member RAS oncogene family & 2.14 & 0.00046 \\ Hs.2007 & NM\_000639 & FASLG & Fas ligand (TNF superfamily, member 6) & 2.09 & 0.00020 \\ \hline \multicolumn{5}{c}{Genes down-regulated by Fraction E plus photo-activation} \\ \hline Hs.591834 & NM\_003844 & TNFRSF10A & Tumor necrosis factor receptor superfamily, member & -4.35 & 0.00046 \\ Hs.434980 & NM\_000484 & APP & Amyloid beta (A4) precursor protein & -2.73 & 0.13269 \\ Hs.1437 & NM\_000152 & GAA & Glucosidase, alpha; acid & -2.59 & 0.00507 \\ Hs.189782 & NM\_018202 & TMEM57 & Transmembrane protein 57 & -2.19 & 0.00537 \\ Hs.643120 & NM\_000875 & IGF1R & Insulin-like growth factor 1 receptor & -2.15 & 0.02531 \\ \hline \multicolumn{5}{c}{Genes up-regulated by Pheophorbide \(a\) and Fraction E treatment plus photo-activation} \\ \hline Hs.241570 & NM\_000594 & TNF & Tumor necrosis factor & 3.75 & 0.00040 \\ Hs.744830 & NM\_000125 & ESR1 & Estrogen receptor 1 & 3.67 & 0.00032 \\ Hs.592068 & NM\_020655 & JPH3 & Junctionbilin 3 & 2.55 & 0.00022 \\ Hs.592244 & NM\_000074 & CD40 LG & CD40 ligand & 2.19 & 0.00024 \\ Hs.32949 & NM\_005218 & DEFB1 & Defensin, beta 1 & 2.19 & 0.00019 \\ Hs.87236 & NM\_012188 & FOXI 1 & Forkhead box I1 & 2.19 & 0.00019 \\ Hs.856 & NM\_000619 & IFNG & Interferon, gamma & 2.19 & 0.00132 \\ Hs.700350 & NM\_000207 & INS & Insulin & 2.19 & 0.00019 \\ Hs.519680 & NM\_001145805 & IRGM & Immunity-related GTPase family, M & 2.19 & 0.00021 \\ Hs.553833 & NM\_001004467 & ORI0J3 & Olfactory receptor, family 10, subfamily J, member 3 & 2.19 & 0.00009 \\ Hs.442337 & NM\_176823 & S100A7A & S100 calcium binding protein A7A & 2.19 & 0.000019 \\ \hline \multicolumn{5}{c}{Genes down-regulated by Pheophorbide \(a\) and Fraction E treatment plus photo-activation} \\ \hline Hs.434980 & NM\_000484 & APP & Amyloid beta (A4) precursor protein & -9.80 & 0.03694 \\ Hs.1437 & NM\_000152 & GAA & Glucosidase, alpha; acid & -4.91 & 0.00267 \\ Hs.269027 & NM\_014568 & GALNT5 & UDP-N-acetyl-alpha-D-galactosamine:polypeptide & -4.39 & 0.00055 \\ \multicolumn{5}{c}{N-acetylgalactosamine} \\ \hline Hs.434980 & NM\_000484 & APP & Amyloid beta (A4) precursor protein & -9.80 & 0.03694 \\ Hs.1437 & NM\_000152 & GAA & Glucosidase, alpha; acid & -4.91 & 0.00267 \\ Hs.269027 & NM\_014568 & GALNT5 & UDP-N-acetyl-alpha-D-galactosamine:polypeptide & -4.39 & 0.00055 \\ \multicolumn{5}{c}{N-acetylgalactosamine} \\ \hline \hline \end{tabular}
\end{table}