## 3 Results and Discussion
### Correlation Analysis  
The correlation analysis did not highlight an apparent influence of the total polyphenols on the cholinesterase-inhibitory activities exhibited by the five legume honeys, except ACHe, where a moderate influence exerted by the total content of these metabolites was noted (\(\rho=0.46\)). This partially agrees with [PERSON] [40], who noted a correlation between total polyphenol content and cholinesterase-inhibitory activity (\(\rho=0.33\) for TPC/AChE; \(\rho=0.48\) for TPC/BChE). A naturally more incisive influence was noted in the antioxidant activity. In this case, the effect of total polyphenols was evident, so much so that we recorded a correlation value of \(\rho=0.93\) in the TEAC test compared to \(\rho=-0.91\) in the DPPH test, where, as we know, the antioxidant efficacy is measured in terms of IC\({}_{50}\). The correlation coefficients indicated a more significant correlation between ACHe-inhibitory action and antioxidant activity (DPPH and TEAC), so much so that the correlation coefficient found between ACHe-inhibitory activity and TEAC was 0.67, and the correlation coefficient between ACHe-inhibitory activity and DPPH was \(\rho=-0.14\). The correlation between antioxidant activity and BCHe-inhibitory activity (IC\({}_{50}\)) was much more pronounced; here, the BChE and TEAC correlation coefficients were equal to 0.95, while the BChE and DPPH correlation coefficients were equal to \(-0.74\). As regards the inhibitory action on tyrosinase, we observed a good correlation with the presence of total polyphenols, which seemed to have influenced the inhibitory activity of tyrosinase on L tyrosine more (\(\rho=0.861\)), comparedto that exerted by tyrosinase on L DOPA (\(\rho=-0.47\)). The good influence exerted by total polyphenols on the ability to inhibit tyrosinase confirms--indeed, reinforces--what has already been described by [PERSON] et al. [103], in whose work, studying Euphoria honey, a correlation value between TPC and tyrosinase-inhibitory activity of \(\rho=0.56\) was noted. The anti-inflammatory activity instead seemed to be influenced more by the presence of vitamin C (\(\rho=0.65\)); on the contrary, total polyphenols appeared to influence it negatively (\(\rho=-0.45\)). Compared to the quantity of individual polyphenols, at least those most present in the various types of honey, the correlation analysis highlights a strong influence of gallic acid on the tyrosinase-inhibitory activity of honey on L-tyrosine (\(\rho=0.84\)). This also agrees with [PERSON] et al. [10], who noted a good neuroprotective effect of gallic acid and quercetin in honey. Instead, the metabolite HMF seemed to affect, above all, the AChE-inhibitory action of honey (\(\rho=0.84\)). When present in the honey, rutin and taxifolin seemed to influence the honey's inhibitory action, calculated as a percentage of BChE (\(\rho=0.80\) and \(0.75\), respectively). Therefore, flavonoids, such as rutin and taxifolin, can communicate with specific signalling pathways and adjust their activities accordingly, prompting valuable neuroprotective impacts [20; 21; 22; 23; 24; 25; 26; 27; 28; 29; 30; 31; 32; 33; 34; 35; 36; 37; 38; 39; 40; 41; 42; 43; 44; 45; 46; 47; 48; 49; 5  
formulations, or even specific foods, including honey, the standard therapies could be modified or optimized. Bioactive compounds can exert incalculable potential, as proven by their capacity to influence the expression and activity of numerous proteins implicated in oxidative stress and neuroinflammation [110]. As indicated by the results, the legume honeys studied herein showed interesting biochemical characteristics and intriguing in vitro biological properties. As already seen in the case of other monofloral honey, such as _Citrus_ honey, their potential inhibiting action against the three most important enzymes involved in neurodegenerative diseases makes them appealing candidates for implementation in recommended diets or in pharmacological treatment to fight some NDDs, especially in the older adults.