# Recent Applications of Solid Phase Microextraction Coupled to Liquid Chromatography
## 3 Conclusions
\begin{table}
\begin{tabular}{c c c c c c c c} \hline \hline
**Application** & **Analyte** & **Matrix** & **Coating** & **Desorption** & **Detector** & **LOQ** & **Ref** \\ \hline \multirow{4}{*}{**Food**} & \multirow{2}{*}{\begin{tabular}{c} OPPs/CMs \\ insecticides \\ \end{tabular} } & \multirow{2}{*}{\begin{tabular}{c} honey \\ \end{tabular} } & \multirow{2}{*}{CW/TPR} & \multirow{2}{*}{on-line} & \multirow{2}{*}{MS/MS} & \multirow{2}{*}{(CCa) 1–55 ng/g} & [58] \\ \cline{2-3} \cline{5-7}  & pesticides & & & & & \\ \cline{2-3} \cline{5-7}  & triazoles & & & & & \\ \cline{2-3} \cline{5-7}  & staisclates & & & & & & \\ \cline{2-3} \cline{5-7}  & isoflav & & & & & & \\ \cline{2-3} \cline{5-7}  & trans-resveratrol & & & & & & \\ \hline \multirow{4}{*}{**Environmental**} & \multirow{4}{*}{\begin{tabular}{c} Pharmacoeticals \\ -methoxyfenoterol \\ \end{tabular} } & \multirow{4}{*}{\begin{tabular}{c} rawstewater \\ \end{tabular} } & \multirow{4}{*}{CW/TPR} & \multirow{4}{*}{on-line} & \multirow{4}{*}{\
\begin{tabular}{c} MS/MS, \\ ion trap \\ \end{tabular} } & \multirow{4}{*}{0.005–0.05 ng/mL} & [64] \\ \cline{2-3} \cline{5-7}  & chloramphenicol & & & & & & \\ \cline{2-3} \cline{5-7}  & - & Environment./Biological & & & & & \\ \cline{2-3} \cline{5-7}  & antibacterials & river & & & & & \\ \cline{2-3} \cline{5-7}  & EDCs & seawater & & & & & & \\ \cline{2-3} \cline{5-7}  & \multirow{2}{*}{BFRs} & \multirow{2}{*}{tap water} & \multirow{2}{*}{PDMS/DVB} & \multirow{2}{*}{on-line} & \multirow{2}{*}{
\begin{tabular}{c} MS/MS, \\ QqP \\ \end{tabular} } & \multirow{2}{*}{(LOD) 0.01–0.04 ng/mL} & [69] \\ \cline{2-3} \cline{5-7}  & & & & & & & \\ \hline \hline \end{tabular}
\end{table} 
Table 2: Food and environmental applications of SPME-LC. \begin{table}
\begin{tabular}{c c c c c c c} \hline \hline
**Application** & **Analyte** & **Matrix** & **Coating** & **Desorption** & **Detector** & **LOQ** & **Ref** \\ \hline \multirow{4}{*}{**Food**} & \multirow{2}{*}{\begin{tabular}{c} OPPs/CMs \\ insecticides \\ \end{tabular} } & \multirow{2}{*}{\begin{tabular}{c} honey \\ \end{tabular} } & \multirow{2}{*}{CW/TPR} & \multirow{2}{*}{on-line} & \multirow{2}{*}{MS/MS} & \multirow{2}{*}{(CCa) 1–55 ng/g} & [58] \\ \cline{2-3} \cline{5-7}  & insecticides & & & & & \\ \cline{2-3} \cline{5-7}  & & & & & & \\ \cline{2-3} \cline{5-7}  & triazoles & & & & & & \\ \cline{2-3} \cline{5-7}  & staisclates & & & & & & \\ \cline{2-3} \cline{5-7}  & isoflavones & & & & & & \\ \cline{2-3} \cline{5-7}  & trans-resveratrol & & & & & & \\ \hline \hline \multirow{4}{*}{**Environmental**} & \multirow{2}{*}{\begin{tabular}{c} Pharmacoeticals \\ -methoxyfenoterol \\ \end{tabular} } & \multirow{2}{*}{\begin{tabular}{c} rawstewater \\ \end{tabular} } & \multirow{2}{*}{CW/TPR} & \multirow{2}{*}{on-line} & \multirow{2}{*}{\
\begin{tabular}{c} MS/MS, \\ ion trap \\ \end{tabular} } & \multirow{2}{*}{0.005–0.05 ng/mL} & [64] \\ \cline{2-3} \cline{5-7}  & chloramphenicol & & & & & \\ \cline{2-3} \cline{5-7}  & - & Environment./Biological & & & & \\ \cline{2-3} \cline{5-7}  & antibacterials & river & & & & \\ \cline{2-3} \cline{5-7}  & EDCs & seawater & & & & & \\ \cline{2-3} \cline{5-7}  & \multirow{2}{*}{BFRs} & \multirow{2}{*}{tap water} & \multirow{2}{*}{PDMS/DVB} & \multirow{2}{*}{on-line} & \multirow{2}{*}{
\begin{tabular}{c} MS/MS, \\ QqP \\ \end{tabular} } & \multirow{2}{*}{(LOD) 0.01–0.04 ng/mL} & [69] \\ \cline{2-3} \cline{5-7}  & & & & & & \\ \hline \hline \end{tabular}
\end{table} 
Table 1: _Cont._indispensable for many partitioning, in vivo, and/or metabolomics applications. The online desorption mode is also widely used, as demonstrated by several applications carried out with the commercial interface as well as by studies dedicated to its improvement. Conceptualization, C.Z. and A.A.; methodology, C.Z. and A.A.; software, C.Z. and A.A.; validation, C.Z. and A.A.; formal analysis, C.Z. and A.A.; investigation, C.Z. and A.A.; resources, C.Z. and A.A.; data curation, C.Z. and A.A.; writing--original draft preparation, C.Z.