## 3 Results
### Work Productivity and Activity Impairment  
Among students and employed or self-employed patients with available data, 29.7% (44/148) reported missing school or work due to AD for at least 2 days in the last month; the percentages among m-AD and s-AD patients were 20.2% (19/94) and 46.3% (25/54), respectively. WPAI:GH outcomes in the overall population and among those reporting missed time or impairment are presented in Table 3. Interestingly, although absenteeism \begin{table}
\begin{tabular}{l c c c c c} \hline \hline  & \multicolumn{5}{c}{**OLS Estimates (of Mean DLQI Total Score)**} \\ \cline{2-6}  & **n** & \begin{tabular}{c} **Crude Betas** \\ **(95\% CI)** \\ \end{tabular} & \begin{tabular}{c} **\(p\)-Value** \\ **(95\% CI)** \\ \end{tabular} & \
\begin{tabular}{c} **Adjusted Betas** \\ **(95\% CI)** \\ \end{tabular} &
\begin{tabular}{c} **\(p\)-Value** \\ **(95\% CI)** \\ \end{tabular} \\ \hline EASI score & 187 * & 0.18 (0.09–0.27) & \textless{}0.001 & 0.12 (0.00–0.23) + & 0.044 \\ PP-NRS total score & 187 * & 1.34 (0.97–1.71) & \textless{}0.001 & 1.11 (0.74–1.47) + & \textless{}0.001 \\ Sleep disturbance (VAS) & 185 ** & 1.10 (0.80–1.39) & \textless{}0.001 & 0.96 (0.67–1.26) + & \textless{}0.001 \\ Pain intensity NRS score & 187 * & 0.87 (0.57–1.16) & \textless{}0.001 & 0.64 (0.34–0.94) + & \textless{}0.001 \\ \hline \hline \end{tabular}  
* Including 3 EASI-based mild cases. *
* Including 1 EASI-based mild case.
* Adjusted for baseline factors of interest: age at study visit (years; continuous), sex, educational status (\(\geq\)Bachelor’s versus \(<\)Bachelor’s degree), employment status (employed versus other), BMI (kg/m\({}^{2}\); continuous), vIGA-AD score (3 versus 4), duration of AD (years; continuous), BSA (%; continuous). Abbreviations: AD, atopic dermatitis; BSA, body surface area; CI, confidence interval; DLQI, Dermatology Life Quality Index; EASI, Eczema Area and Severity Index; M2S, moderate-to-severe; n, number of patients with variable; NRS, numerical rating scale; OLS, ordinary least squares; PP-NRS, Peak Printing Numerical Rating Scale; PRO, patient-reported outcome; VAS, visual analogue score; vIGA, validated Investigator’s Global Assessment.  
\end{table} 
Table 2: Association of EASI and PROs with DLQI total score through univariate linear regression model adjusted for baseline factors of interest through multivariate linear regression model in the overall M2S population. and presenteeism are more often reported in s-AD than m-AD patients, the impact on those reporting is similar in the two subgroups. \begin{table}
\begin{tabular}{l l c c c} \hline  & & **Overall** & **m-AD** & **s-AD** \\  & & **(N = 184)** & **(N = 117)** & **(N = 67)** \\ \hline \multicolumn{4}{l}{**All patients**} \\ \hline Employed, n & & 112 & 72 & 40 \\ \hline \multirow{3}{*}{Absenteeism} & Completion rate, \% (n/N) & 97.3 (109/112) & 95.8 (69/72) & 100.0 (40/40) \\  & Mean (SD) score, \% & 4.9 (12.0) & 4.9 (14.1) & 4.7 (7.2) \\  & Median (IQR) score, \% & 0.0 (0.0–4.8) & 0.0 (0.0–2.0) & 0.0 (0.0–6.0) \\ \hline \multirow{3}{*}{Presenteeism} & Completion rate, \% (n/N) & 99.1 (111/112) & 98.6 (71/72) & 100.0 (40/40) \\  & Mean (SD) score, \% & 27.1 (26.3) & 25.8 (27.0) & 29.5 (25.3) \\  & Median (IQR) score, \% & 20.0 (0.0–40.0) & 20.0 (0.0–40.0) & 20.0 (10.0–45.0) \\ \hline \multirow{3}{*}{Work productivity loss} & Completion rate, \% (n/N) & 97.3 (109/112) & 95.8 (69/72) & 100.0 (40/40) \\  & Mean (SD) score, \% & 29.8 (27.3) & 28.0 (28.5) & 32.8 (25.2) \\ \cline{1-1}  & Median (IQR) score, \% & 23.8 (2.4–50.0) & 20.0 (0.0–46.6) & 26.9 (10.0–51.0) \\ \hline \multirow{3}{*}{Activity impairment} & Completion rate, \% (n/N) & 100.0 (184/184) & 100.0 (117/117) & 100.0 (67/67) \\  & Mean (SD) score, \% & 34.2 (30.0) & 29.5 (28.6) & 42.4 (30.7) \\ \cline{1-1}  & Median (IQR) score, \% & 30.0 (5.0–60.0) & 20.0 (0.0–50.0) & 40.0 (20.0–70.0) \\ \hline \end{tabular}
\end{table}