###### Abstract
Additionally, plant-based proteins can provide several health benefits that animal-based proteins may not. For example, the use of protein isolates (hydrolysates) from peas have been shown to lower blood pressure and reduce the risk of kidney disease [8; 9], the body metabolizing this protein similar to whey-based ones [10]. Almond protein powders are also metabolized similar to well-known whey-based proteins [11], being as well associated with beneficial effects against cardiometabolic diseases [12; 13]. Spirulina powder's beneficial effects are identified in particular reference to obesity, hypertension and cardiovascular diseases [14; 15]. Additionally, _Pleurotus_ spp. protein powders have been associated with beneficial aids in various chronic diseases [16; 17; 18], as well as yeast protein powders promoting muscle protein synthesis, rapid recovery and biodiversity of gut-microbiota [19; 20]. In summary, the origin of protein is an important consideration for optimizing health benefits. Consuming a variety of plant-based proteins can provide a range of health benefits, while minimizing the consumption of animal-based proteins may reduce the risk of chronic diseases associated with a high intake of saturated fat and cholesterol. In addition, it is well known that compounds with antioxidant activity contribute to the cells' amelioration and/or protection of oxidative stress [21]. Synthetic antioxidants have been widely used in different industries being known for their health hazards such as liver damage and carcinogenesis [22]. Natural antioxidant peptides and proteins are an alternative in terms of safety and availability [23]. In the case of antioxidant peptides, the potential to reduce the risk of aging, inflammation and cardiovascular disease have been demonstrated, thus improving human health [24; 25]. Up to date, numerous antioxidant peptides from various animal, plant and microbial proteins have been identified [26; 27; 28; 29] with different mechanisms of action: inhibition of lipid oxidation, scavengers of free radicals and/or chelate pro oxidative metals [25; 28; 30; 31]. Various studies have shown that the antioxidant properties of proteins are related to their composition, sequence, structure and hydrophobicity [11; 32; 33; 34]. Keeping this in mind, we can highlight several advantages of consuming proteins of plant origin, such as lower saturated fat and cholesterol content, higher values of fiber, vitamins, minerals, and antioxidants compared to animal-based proteins, which are associated with a reduced risk of chronic diseases [35], environmental sustainability [36], cost-effectiveness, versatility and suitability for various dietary restrictions [37; 38; 39; 40]. Overall, consuming proteins of plant origin can be a beneficial choice for both personal health and the health of the planet. Although dietary supplementation seems like a viable solution that can balance our busy and demanding life and enhance or help maintain normal physiological functions of the human body, varying pros and cons have been associated with them regarding the absorption rate, bioavailability, cytotoxicity and actual nutritional benefits. Especially since according to the 2020 Agri-Food Fraud Network (FFN) report based on Regulation (EU) No. 1169/2011 on the food information to consumers, the majority of non-compliances regarded mislabeling, support documentation and product dilution/addition [41]. Therefore, our study analyzed the nutritional profile, physico-chemical properties, antioxidant activity and cytotoxicity degree of five high protein ingredients represented by: pea powder, almond powder, yeast powder, spirulina powder and _Pleurotus_ spp. flour. These ingredients are frequently used in various diets, workout regimes or as meal replacements; as we know, the supplements are not as restricted by legislation, therefore mistakes and misconceptions are more likely to occur. Therefore, our study focuses on analyzing three key domains capable of outlining the safety consumption limits of ingredients such as these.