## 4 Discussion
\begin{table}
\begin{tabular}{c c c c} \hline \hline \multirow{2}{*}{**Group Treatment**} & \multicolumn{3}{c}{**Fibrocyte (cells/mm\({}^{2}\))**} \\ \cline{2-4}  & **Day 3** & **Day 7** & **Day 14** \\ \hline Normal (NC) & 22.0 \(\pm\) 0.5 & 26.0 \(\pm\) 0.4 & 21.0 \(\pm\) 0.5 \\ Diabetic (DC) & 10.0 \(\pm\) 0.7 & 10.0 \(\pm\) 0.9 & 9.0 \(\pm\) 0.5 \\ Alginate ointment (DA) & 15.0 \(\pm\) 0.5 & 19 \(\pm\) 0.7 & 14.0 \(\pm\) 1.9 \\ Alginate–magnosteen find ointment (DAM) & 22.0 \(\pm\) 0.2 ** & 28 \(\pm\) 0.5 ** & 20.0 \(\pm\) 0.7 ** \\ \hline \hline \end{tabular} Asterisk notation in the table shows the result of the statistical test (\(\alpha<0.05\)). ** notation shows insignificant differences with NC, but significant differences with DC. ** = \(\alpha\leq 0.01\).  
\end{table} 
Table 6: Cell counts considering the mean and standard deviation of fibrocytes. \begin{table}
\begin{tabular}{c c c c} \hline \hline \multirow{2}{*}{**Group Treatment**} & \multicolumn{3}{c}{**Neutrophil (cells/mm\({}^{2}\))**} \\ \cline{2-4}  & **Day 3** & **Day 7** & **Day 14** \\ \hline Normal (NC) & 57.0 \(\pm\) 1.4 & 28.0 \(\pm\) 4.9 & 11.0 \(\pm\) 1.4 \\ Diabetic (DC) & 118.0 \(\pm\) 1.2 & 55.0 \(\pm\) 1.9 & 38.0 \(\pm\) 1.4 \\ Alginate Güntment (DA) & 77.0 \(\pm\) 1.2 & 43.0 \(\pm\) 6.4 & 28.0 \(\pm\) 0.4 \\ Alginate–magnosteen find ointment (DAM) & 55.0 \(\pm\) 0.9 ** & 35.0 \(\pm\) 2.1 * & 14.0 \(\pm\) 0.2 ** \\ \hline \hline \end{tabular} Asterisk notation in the table shows the result of the statistical test (\(\alpha<0.05\)). ** and ** notation shows insignificant differences with NC but significant differences with DC. * = \(\alpha<0.05\), ** = \(\alpha\leq 0.01\).  
\end{table} 
Table 4: Cell counts considering the mean and standard deviation of neutrophils. \begin{table}
\begin{tabular}{c c c c} \hline \hline \multirow{2}{*}{**Group Treatment**} & \multicolumn{3}{c}{**Fibrocyte (cells/mm\({}^{2}\))**} \\ \cline{2-4}  & **Day 3** & **Day 7** & **Day 14** \\ \hline Normal (NC) & 2673.0 \(\pm\) 22.9 & 882.0 \(\pm\) 44.1 & 0.0 \(\pm\) 0.0 \\ Diabetic (DC) & 4786.0 \(\pm\) 63.9 & 3636 \(\pm\) 37.0 & 0.0 \(\pm\) 0.0 \\ Alginate Güntment (DA) & 3030.0 \(\pm\) 126.6 & 1002.0 \(\pm\) 11.5 * & 0.0 \(\pm\) 0.0 \\ Alginate–magnosteen find ointment (DAM) & 2502.0 \(\pm\) 10.4 ** & 726.0 \(\pm\) 29.7 ** & 0.0 \(\pm\) 0.0 \\ \hline \hline \end{tabular} Asterisk notation in the table shows the result of the statistical test (\(\alpha<0.05\)). ** and ** notation shows insignificant differences with NC but significant differences with DC. * = \(\alpha\leq 0.01\).  
\end{table} 
Table 3: Counts considering the mean and standard deviation of wound width. \begin{table}
\begin{tabular}{c c c c} \hline \hline \multirow{2}{*}{**Group Treatment**} & \multicolumn{3}{c}{**Fibrocyte (cells/mm\({}^{2}\))**} \\ \cline{2-4}  & **Day 3** & **Day 7** & **Day 14** \\ \hline Normal (NC) & 15.0 \(\pm\) 0.5 & 21.0 \(\pm\) 0.7 & 5.0 \(\pm\) 0.2 \\ Diabetic (DC) & 37.0 \(\pm\) 0.7 & 40.0 \(\pm\) 3.1 & 17.0 \(\pm\) 0.7 \\ Alginate Güntment (DA) & 21.0 \(\pm\) 2.1 & 26.0 \(\pm\) 0.5 * & 9.0 \(\pm\) 0.2 \\ Alginate–magnosteen find ointment (DAM) & 15.0 \(\pm\) 0.5 ** & 20.0 \(\pm\) 0.5 ** & 5.0 \(\pm\) 0.2 ** \\ \hline \hline \end{tabular} Asterisk notation in the table shows the result of the statistical test (\(\alpha<0.05\)). ** and ** notation shows insignificant differences with NC but significant differences with DC. * = \(\alpha<0.05\), ** = \(\alpha\leq 0.01\).  
\end{table} 
Table 5: Cell counts considering the mean and standard deviation of macrophages. Fibroblasts are cells that have a role in the proliferation phase. These cells have the function to regulate collagen, glycosaminoglycan, proteoglycan, fibronectin, and elastin as the extracellular matrix components [49; 50]. In addition, fibroblasts also play a role in collagen. The presence of an increase and decrease in the number of fibroblasts is the same as observed in the measurement of the number of fibrocytes in the wound.