## 3 Results
### Local Genetic Correlation Analysis
At this locus, we also observed a significant positive genetic correlation between MDD and BMI (rho = 0.48, r\({}^{2}\) = 0.23, adj \(p\) = 0.012), as well as between insomnia and BMI (rho = 0.55, r\({}^{2}\) = 0.31, adj \(p\) = 0.001) or CRP (rho = 1, r\({}^{2}\) = 1, adj \(p\) = 0.0002). When adjusting for BMI, the partial correlation analysis between MDD and insomnia was still significant (r\({}^{2}\)-MDD\(\_\)BMI = 0.23, r\({}^{2}\)-MDD\(\_\)BMI = 0.31, rho partial correlation = 1, p partial correlation = 0.0003). Results for partial correlation analysis between MDD and insomnia adjusting for CRP are not reported as LAVA deemed estimates to be unreliable (estimate out of bounds). \begin{table}
\begin{tabular}{c c c c c c c c} \hline \hline  & & & & \multicolumn{2}{c}{**MDD**} & \multicolumn{2}{c}{**Insomnia**} \\ \hline
**SNP(s)** & **Chr** & **Start Locus** & **Stop Locus** & \(p\) & **adj \(p\)** & \(p\) & **adj \(p\)** \\ \hline rs77217059 & 2 & 57952946 & 59251996 & 3.6 \(\times\) 10\({}^{-7}\) & 2.2 \(\times\) 10\({}^{-5}\) & 6.8 \(\times\) 10\({}^{-11}\) & 4.1 \(\times\) 10\({}^{-9}\) \\ rs2111592 & 2 & 207726595 & 208674588 & 4.7 \(\times\) 10\({}^{-12}\) & 2.8 \(\times\) 10\({}^{-10}\) & 0.046 & 1 \\ rs9831648 & 3 & 47588462 & 50387742 & 4.1 \(\times\) 10\({}^{-5}\) & **0.002** & 7.3 \(\times\) 10\({}^{-10}\) & 4.4 \(\times\) 10\({}^{-8}\) \\ rs66511648, & 3 & 117241645 & 118086929 & 0.068 & 1 & 2.7 \(\times\) 10\({}^{-5}\) & **0.002** \\ rs1456193 & & & & & & & \\ rs309439 & 5 & 87943483 & 89584466 & 2.3 \(\times\) 10\({}^{-7}\) & 1.4 \(\times\) 10\({}^{-5}\) & 1.2 \(\times\) 10\({}^{-11}\) & 7.2 \(\times\) 10\({}^{-10}\) \\ rs30266, & & & & & & & \\ rs79760 & 5 & 103788461 & 104850490 & 4.0 \(\times\) 10\({}^{-6}\) & **0.0002** & 0.01 & 0.600 \\ rs150186873 & 6 & 26396201 & 27261035 & 6.8 \(\times\) 10\({}^{-12}\) & 4.1 \(\times\) 10\({}^{-10}\) & 0.09 & 1 \\ rs6938026 & 6 & 42103739 & 43770626 & 0.006 & 0.360 & 1.1 \(\times\) 10\({}^{-10}\) & 6.6 \(\times\) 10\({}^{-9}\) \\ rs370771 & 6 & 104951345 & 106053915 & 0.017 & 1 & 0.003 & 0.180 \\ rs10235664 & 7 & 1366973 & 2473749 & **0.0001** & **0.006** & 0.005 & 0.300 \\ rs6984111 & 8 & 9835864 & 10478851 & 0.003 & 0.180 & 0.057 & 3.420 \\ rs61914045 & 12 & 51769420 & 53039987 & 1.6 \(\times\) 10\({}^{-7}\) & 9.6 \(\times\) 10\({}^{-6}\) & 0.007 & 0.420 \\ rs9576155 & 13 & 37499811 & 38290689 & 0.0084 & 0.504 & 0.0022 & 0.132 \\ rs9536381, & & & & & & & \\ rs9563152 & & & & & & & \\ rs1950829 & 14 & 41614834 & 42562550 & 7.5 \(\times\) 10\({}^{-7}\) & 4.5 \(\times\) 10\({}^{-5}\) & 0.0021 & 0.126 \\ \hline \hline \end{tabular} The table reports significance of univariate tests to assess local heritability for the investigated loci for MDD and insomnia. The adj columns report \(p\)-values adjusted according to Bonferroni based on the number of conducted tests (n = 60). Significant results are reported in bold. Abbreviations: Chr, chromosome; MDD, major depressive disorder; SNP, single nucleotide polymorphism.  
\end{table} 
Table 6: Results of the univariate tests to assess local heritability of selected loci for MDD and insomnia.