## 2 Materials and Methods
### Chemistry
(6-Fluoroquinazolin-4-yl)[2-[4-(trifluoromethylomethyl)phenyl]lethyl]amine, **19a**  
Following general procedure A, using 4-chloro-6-fluoroquinazoline (**16**, 100 mg, 0.55 mmol), 2-[4-(trifluoromethylomethyl)phenyl]ethylamine (112 mg, 0.55 mmol), and potassium carbonate (76 mg, 0.55 mmol) gave **16a** as a white solid (99 mg, 51%). mp 171.6-172.6 \({}^{\circ}\)C; \({}^{1}\)H (500 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 8.70 (s, 1H), 7.89 (dd, \(J\) = 9.1, 5.3 Hz, 1H), 7.52 (ddd, 9.1, 8.2, 2.7 Hz, 1H), 7.32-7.29 (m, 2H), 7.23-7.19 (m, 3H), 5.57 (br.s, 1H), 3.96 (dt, \(J\) = 7.0, 5.8 Hz, 2H), 3.08 (t, \(J\) = 7.0 Hz, 2H). \({}^{13}\)C (125 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 160.0 (d, \(J\) = 248.9 Hz), 159.0, 148.1 (q, \(J\) = 1.9 Hz), 146.5, 137.5, 131.4 (d, \(J\) = 8.4 Hz), 130.1, 122.2 (d, \(J\) = 24.4 Hz), 121.5, 121.3, 120.5 (q, \(J\) = 255.5 Hz), 115.2 (d, \(J\) = 7.9 Hz), 104.7 (d, \(J\) = 22.7 Hz), 42.4, 34.6. \({}^{19}\)F (470 MHz, CDCl\({}_{3}\)) \(\delta\) ppm -57.9 (s, 3F), -112.3 (ddd, \(J\) = 5.4, 8.5, 8.5 Hz, 1F). HRMS (EI), M + 1 calculated for C\({}_{17}\)H\({}_{13}\)F\({}_{4}\)N\({}_{3}\)O, 352.1068, found 352.1078. This compound was shown to inhibit autophagy in referenced patent [22]. (6-Methylquinazolin-4-yl)[2-[4-(trifluoromethylomethyl)phenyl]lethyl]amine, **17a**  
Following general procedure A, using 4-chloro-6-methylquinazoline (**17**, 100 mg, 0.56 mmol), 2-[4-(trifluoromethylomethyl)phenyl]lethylamine (115 mg, 0.56 mmol), and potassium carbonate (77 mg, 0.56 mmol) gave **17a** as an off-white solid (134 mg, 69%). mp 134.3-135.0 \({}^{\circ}\)C; \({}^{1}\)H (500 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 8.67 (s, 1H), 7.77 (d, \(J\) = 8.5 Hz, 1H), 7.58 (dd, \(J\) = 8.5, 1.6 Hz, 1H), 7.36 (s, 1H), 7.31-7.27 (m, 2H), 5.76 (br.s, 1H), 3.94 (dt, \(J\) = 6.9, 5.9 Hz, 2H), 3.08 (t, \(J\) = 7.0 Hz, 2H), 2.50 (s, 3H). \({}^{13}\)C (125 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 158.9, 154.6, 148.0 (q, \(J\) = 1.8 Hz), 147.8, 137.8, 136.1, 134.5, 130.2, 128.5, 121.2, 120.5 (q, \(J\) = 256.9 Hz), 119.4, 114.8, 42.3, 34.7, 21.7. \({}^{19}\)F (470 MHz, CDCl\({}_{3}\)) \(\delta\) ppm -57.9 (s, 3F). HRMS (EI), M + 1 calculated for C\({}_{18}\)H\({}_{16}\)F\({}_{3}\)N\({}_{3}\)O, 348.1318, found 348.1336. (6-Methoxyquinazolin-4-yl)[2-[4-(trifluoromethylomethyl)phenyl]lethyl]amine, **18a**  
Following general procedure A, using 4-chloro-6-methoxyquinazoline (**18**, 100 mg, 0.51 mmol), 2-[4-(trifluoromethylomethyl)phenyl]lethylamine (105 mg, 0.51 mmol), and potassium carbonate (71 mg, 0.51 mmol) gave **18a** as a white solid (93 mg, 50%). mp 144.7-145.2 \({}^{\circ}\)C; \({}^{1}\)H (500 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 8.64 (s, 1H), 7.81 (d, \(J\) = 9.1 Hz, 1H), 7.41 (dd, \(J\) = 9.1, 2.5 Hz, 1H), 7.32-7.26 (m, 2H), 7.20 (d, \(J\) = 8.1 Hz, 2H), 6.82 (d, \(J\) = 2.5 Hz, 1H), 5.65 (br.s, 1H), 3.95 (dt, \(J\) = 6.8, 6.2 Hz, 2H), 3.87 (s, 3H), 3.08 (t, \(J\) = 7.0 Hz, 2H). \({}^{13}\)C (125 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 158.6, 157.6, 153.4, 148.0 (q, \(J\) = 1.8 Hz), 144.9, 137.9, 130.3, 130.2, 123.6, 121.2, 120.5 (q, \(J\) = 258.4 Hz), 115.3, 99.85, 55.6, 42.3, 34.7. \({}^{19}\)F (470 MHz, CDCl\({}_{3}\)) \(\delta\) ppm -57.9 (s, 3F). HRMS (EI), M + 1 calculated for C\({}_{18}\)H\({}_{16}\)F\({}_{3}\)N\({}  
Following general procedure A, using 4-chloro-7-fluoroquinazoline (**19**, 100 mg, 0.55 mmol), 2-[4-(trifluoromethyloormethoxy)phenyl]ethylamine (112 mg, 0.55 mmol), and potassium carbonate (76 mg, 0.55 mol) gave **19a** as off-white crystals (107 mg, 56%). mp 128.9-129.7 \({}^{\circ}\)C; \({}^{1}\)H (500 MHz, CDCl\({}_{3}\)) \(\delta\) ppm 8.69 (s, 1H), 7.60 (dd, \(J\) = 9.1, 5.6 Hz, 1H), 7.49 (dd, \(J\) = 9.8, 2.5 Hz, 1H), 7.32-7.26 (m, 2H), 7.24-7.17 (m, 3H), 5.74 (brs, 1H), 3.96 (dt, \(J\) = 6.9, 5.9 Hz, 2H), 3.07 (t, \(J\) = 7.0 Hz, 2H).