# BODIPY-Based Nanomaterials--Sensing and Biomedical Applications
## 3 Conclusions  
Recent scientific results in the field of novel materials based on metal-based nanostructures and BODIPY derivatives were gathered in this review. Multiple research documents were analyzed concerning the latest discoveries within the scope of BODIPY-based nanomaterials with particular emphasis on their utilization for diagnostic sensing as well as cancer diagnostics and therapy. The collected literature data on the mentioned materials were presented in order to draw the attention of the scientific community to their practical applications, consistently elucidate the topic, and inspire fellow researchers for new findings concerning their expediency in the diagnosis and treatment of tumor ailments as well as in sensing of heavy metals. Many of the discussed BODIPY-modified nanoparticles have found applications in determining biologically significant ions. One interesting example concerns pH detection and toxic chromium(VI) ions detection and their elimination from aqueous solutions. Another example constitutes superparamagnetic/BODIPY connections, which can be applied in the complexation of nickel ions, giving access to unique adsorbents for protein purification in the immobilized metal affinity chromatography method. Other nanoparticles carrying BODIPY's manifested highly selective and sensitive photoreaction with cysteine molecules in biological conditions or constituted a reliable tool for determining the immunosuppressive tacrolimus drug in narrow concentration ranges. Particular attention was given to cancer diagnosis and treatment techniques where metallic nanoparticles/BODIPY's conjunctions firmly distinguished themselves. The aforementioned examples of MOFs with BODIPY were successfully tested for many medical applications. Among these applications were tumor visualization, promoting dye internalization by cancer cells, photothermal imaging, computed and photoacoustic tomography, and significant photodynamic tumor reduction due to improved light-harvesting properties and the heavy-atom effect. The experiments on carbon-coated cobalt nanomagnets bearing nonovalently joined fluorescent BODIPY moieties and covalently attached dendrimeric components showed their expediency as transporting units for multifunctionalization with drug and targeting molecules, especially in cancer treatment. Recently discovered aza-BODIPY probe-containing mesoporous black anatase titanium dioxide nanoplatforms represent highly potential theranostic instruments for effective photothermal and photodynamic cancer therapy. Attachment of another aza-BODIPY derivative to gold nanoparticles allowed ultrasensitive recognition of human fibrosarcoma cell lines to be achieved. Other functionalized golden nanocarriers with BODIPY as guest compounds entrapped in hydrophobic pockets demonstrated promising capabilities for targeting drug delivery in tumor tissues. Silver nanoparticles with iodinated BODIPY molecules inserted through galactose polymer revealed high efficacy in eradicating bacterial infection, bypassing even established drug resistance. In Table 1 we summarize the data collected in this review. Figure 26: The influence of the chemical structure elements of BODIPY dyes on their properties. The collected data encourage further explorations in the area of metallic nanoparticles/ BODIPY conjugates since the provided examples proved their practicality and opened new horizons for discoveries of even more potent biologically active photosensitive nanostructures.