## 2 Materials and Methods
### Data Collection and Evaluation  
Data collection included self-reporting measures. The self-report included data obtained through patient interviews and questionnaires. This information from patients included demographic information (gender, age, and main disease), usability and satisfaction (using a validated System Usability Scale (SUS) questionnaire [40]), and health management attitudes (using an ad hoc Likert-type scale from 1 to 5 that asks questions on self-care, information, autonomy, safety and QoL. It was scored from \"1--Completely disagree\" to \"5--Completely agree\"). The participants were contacted by research teams via telephone or in-person to conduct follow-up interviews regarding their experience with the HRS. The patients were asked about their weekly QoL related to the system. At the end of the pilot, a post-survey was administered to assess several aspects of the patients with the HRS. The post-survey consisted of the QoL questionnaire, SUS questionnaire, and a final questionnaire assessing the level of satisfaction with the use of the HRS. The specific questions included in each of the questionnaires and their objectives are outlined below: \begin{table}
\begin{tabular}{l l l l l} \hline \hline
**Category** & **Inclusion Criteria** & \multicolumn{2}{l}{**Exclusion Criteria**} \\ \hline \multirow{4}{*}{Patients} & \(\bullet\) & Over 60 years & \(\bullet\) & Unwilling to use technology in the project \\  & \(\bullet\) & Understand local language & \(\bullet\) & Unable to follow the requirements of the study \\  & \(\bullet\) & Has a reference person or caregiver in case of dependency & \(\bullet\) & Life expectancy less than 6 months \\  & & & \(\bullet\) & Alcoholism or drug addiction \\ \hline \multirow{4}{*}{Parkinson Disease Patients} & \multirow{4}{*}{\(\bullet\)} & \multirow{4}{*}{Confirmed diagnosis} & \(\bullet\) & Multiple system atrophy \\  & & & \(\bullet\) & Progressive supranuclear palsy \\  & & & \(\bullet\) & Corticobasal syndrome \\  & & & \(\bullet\) & Dementia with Lewy bodies \\ \hline \multirow{4}{*}{Alzheimer Disease Patients} & \multirow{4}{*}{\(\bullet\)} & MMSE between 19 and 28 points & \(\bullet\) & GDS over 6–7 \\  & & & & \\ \hline \multirow{4}{*}{Cardiovascular Disease Patients} & \multirow{4}{*}{\(\bullet\)} & Heart failure with a NYHA grade II–III HF & \multirow{4}{*}{\(\bullet\)} & Arterial coronary & disease \\  & & Stable coronary artery disease or artery coronary disease with or without ST elevation & & (less than 4 weeks ago) \\  & & Atrial fibrillation, pacemaker, and stroke & & Severe aortic stenosis \\ \hline \multirow{4}{*}{C caregivers} & \multirow{4}{*}{\(\bullet\)} & Current care for a participant patient & \multirow{4}{*}{\(\bullet\)} & Do not understand the local language \\  & & Ability to use a smartphone and have basic tech knowledge & & \(\bullet\) & Do not agree to participate in the study \\  & & & \(\bullet\) & In case not living with the patient, provide logistical & \(\bullet\) & Do not sign the informed consent form \\  & & support or be a paid carer or directly employed & & \\ \hline \multirow{4}{*}{Health Professionals} & \multirow{4}{*}{\(\bullet\)} & Socio-health professionals & \multirow{4}{*}{\(\bullet\)} & \multirow{4}{*}{\(\bullet\)} & \multirow{4}{*}{\(\bullet\)} \\  & & Carrying out professional activity in a PCHC participating in the study & & & \\ \cline{1-1}  & & At least one-year professional experience & & & Do not agree to participate in the study \\ \cline{1-1}  & & Ability to provide continuity of care for the patient during the intervention & & \\ \hline \hline \end{tabular}
\end{table} 
Table 2: Criteria for participants in the project. * QP: QoL Proxy. The measure of effectiveness for the TeNDER system was the QoL Proxy surveys, which were used to assess the impact of the system on participants' well-being. The QoL proxy questions included in the survey were carefully designed to capture important aspects of daily life, such as physical activity, self-care, social engagement, and emotional well-being.