# Development and Application of MAGIC-f Gel in Cancer Research and Medical Imaging
## 6 Application of MAGIC-f Gel  
The gel dosimetry field is rapidly growing [54]. Gel dosimetry is applied in various applications for radiation dose measurement where the conventional dosimeter will not give an accurate measurement [54]; the application of polymer gel which was developed before MAGIC-f gel is discussed in several works of the literature [3; 8; 55; 56; 57; 58]. The polymer gel dosimeter replaces the conventional dosimeter from the very basic dosimetry parameters such as percentage depth dose (PDD) in photons and electron beams, to the complex dosimetry parameters, due to its ability to demonstrate the dose distribution in three dimensions [25; 44; 58; 59]. Moreover, the polymer gel has been applied to the dosimetry analysis in simple arrangements, such as nine-field tomotherapy [60], to a more complex anatomical situation, such as tangential breast cancer therapy [61; 62] and scalp treatment with electron beams [63]. Lately, several advancements in the field of polymer gel dosimetry utilized to demonstrate dose distribution from imaging procedure have been made; the benefits are that the dose distribution throughout the desired volume of a patient can be evaluated without using point dosimeters, and the dose averaging along the line or volume is avoided [64]. Medical science has developed various new techniques/therapies for the treatment of various diseases for complicated dose distributions. On the one hand, ion chamber and thin film fail in the measurement of the complex dose distribution, whereas hand gel dosimeters are useful in the measurement of dose for complex dose distribution produced by such treatments as 3D conformal radiation therapy (3D CRT), intensity-modulated radiation therapy (IMRT), and brachytherapy [25; 65; 66; 67; 68]. The complexity of dose distribution in brachytherapy is due to the high dose rate produced by the therapy, which introduces the temperature gradients influencing the polymerization of acrylamide monomer in polymer gel [31; 68; 69; 70]. The application area of the polymer gel broadens amid the rapid growing medial technology; these applications apply to several other functions, such as internal dosimetry, calculation of neutron [71; 72; 73; 74], particle dose distribution [75; 76; 77; 38; 78], and in the evaluation of tissue heterogeneities [78; 79; 80; 81; 82; 55]. The trend of interest in polymer gel application continues with more innovation in the polymer gel dosimetry by making it more efficient and easier to use. As an outcome of the innovation MAGIC-f gel is most suitable for a wide range of applications; many types of research have been conducted on the application of MAGIC-f gel to determine the dose distribution at different conditions for various applications, [PERSON] et al. applied MAGIC-f gel to measure of three-dimensional dose distribution from a tomotherapy device. In this research, the gel phantom was simulated with a prostate intensity-modulated radiation therapy (IMRT), a tomotherapy device was used for treatment. Then, the spin-spin relaxation rate (\(R2\)) distribution measured by magnetic resonance imaging was evaluated for the dose distribution; a high similarity was found in the comparison of dose distribution measured from the gel and calculated one from the treatment planning system (TPS), the comparison was based on two quantities, the relative dose profile and gamma index analysis. Hence, this work concludes that the MAGIC-f gel is a promising gel for three-dimensional dose distribution measurement [36]. The advancements in nuclear medicine and cancer treatment using radionuclides require a specific dosimetric knowledge; Monte Carlo simulations are used extensively for experimental study to verify the dose distribution in the new polymer gel dosimeter (MAGIC-f) that is used in nuclear medicine [3]. [PERSON] et al.