## 3 Results
### biocompatibility with Colon Epithelial Cells
\begin{table}
\begin{tabular}{c c c c c} \hline  & **L\({}^{\bullet}\)** & **a\({}^{\bullet}\)** & **b\({}^{\bullet}\)** & **Chroma** & **\(\Delta\)E** \\ \hline Control 1 & 85.75 \(\pm\) 0.10 \({}^{\text{a}}\) & \(-\)1.13 \(\pm\) 0.03 \({}^{\text{k}}\) & 10.67 \(\pm\) 0.53 \({}^{\text{c}}\) & 10.73 \(\pm\) 0.52 \({}^{\text{h}}\) & \\ A & 52.36 \(\pm\) 0.45 \({}^{\text{d}}\) & 9.43 \(\pm\) 0.10 \({}^{\text{f}}\) & \(-\)13.14 \(\pm\) 0.20 \({}^{\text{8}}\) & 16.17 \(\pm\) 0.21 \({}^{\text{de}}\) & 42.34 \(\pm\) 0.44 \({}^{\text{d}}\) \\ E & 44.49 \(\pm\) 1.11 \({}^{\text{f}}\) & 31.13 \(\pm\) 0.73 \({}^{\text{a}}\) & \(-\)24.20 \(\pm\) 0.67 \({}^{\text{h}}\) & 39.44 \(\pm\) 0.42 \({}^{\text{c}}\) & 62.94 \(\pm\) 0.56 \({}^{\text{c}}\) \\ Control 2 & 74.26 \(\pm\) 0.14 \({}^{\text{e}}\) & 3.38 \(\pm\) 0.04 \({}^{\text{h}}\) & 14.90 \(\pm\) 0.15 \({}^{\text{b}}\) & 15.28 \(\pm\) 0.16 \({}^{\text{e}}\) & \\ B & 47.03 \(\pm\) 0.41 \({}^{\text{e}}\) & 12.94 \(\pm\) 0.10 \({}^{\text{e}}\) & \(-\)13.39 \(\pm\) 0.12 \({}^{\text{d}}\) & 13.01 \(\pm\) 0.11 \({}^{\text{8}}\) & 33.14 \(\pm\) 0.32 \({}^{\text{f}}\) \\ F & 37.53 \(\pm\) 0.17 \({}^{\text{h}}\) & 23.44 \(\pm\) 0.49 \({}^{\text{d}}\) & \(-\)33.96 \(\pm\) 0.07 \({}^{\text{f}}\) & 41.27 \(\pm\) 0.23 \({}^{\text{b}}\) & 64.33 \(\pm\) 0.13 \({}^{\text{b}}\) \\ Control 3 & 77.74 \(\pm\) 0.03 \({}^{\text{b}}\) & 0.48 \(\pm\) 0.01 \({}^{\text{j}}\) & 14.36 \(\pm\) 0.03 \({}^{\text{b}}\) & 14.37 \(\pm\) 0.03 \({}^{\text{f}}\) & \\ C & 46.11 \(\pm\) 1.06 \({}^{\text{e}}\) & 7.85 \(\pm\) 0.01 \({}^{\text{g}}\) & \(-\)11.02 \(\pm\) 0.36 \({}^{\text{f}}\) & 13.53 \(\pm\) 0.29 \({}^{\text{g}}\) & 41.22 \(\pm\) 0.59 \({}^{\text{d}}\) \\ G & 40.37 \(\pm\) 0.29 \({}^{\text{g}}\) & 25.06 \(\pm\) 0.06 \({}^{\text{c}}\) & \(-\)29.32 \(\pm\)0.10 \({}^{\text{i}}\) & 38.57 \(\pm\) 0.49 \({}^{\text{c}}\) & 62.52 \(\pm\) 0.19 \({}^{\text{c}}\) \\ Control 4 & 75.64 \(\pm\) 0.02 \({}^{\text{c}}\) & 2.96 \(\pm\) 0.01 \({}^{\text{i}}\) & 17.01 \(\pm\) 0.02 \({}^{\text{a}}\) & 17.26 \(\pm\) 0.01 \({}^{\text{d}}\) & \\ D & 43.79 \(\pm\) 0.01 \({}^{\text{fg}}\) & 8.92 \(\pm\) 0.02 \({}^{\text{f}}\) & \(-\)5.11 \(\pm\) 0.06 \({}^{\text{e}}\) & 10.28 \(\pm\) 0.05 \({}^{\text{h}}\) & 39.23 \(\pm\) 0.04 \({}^{\text{e}}\) \\ H & 36.40 \(\pm\) 0.02 \({}^{\text{h}}\) & 27.10 \(\pm\) 0.52 \({}^{\text{b}}\) & \(-\)38.31 \(\pm\) 0.05 \({}^{\text{k}}\) & 46.93 \(\pm\) 0.31 \({}^{\text{a}}\) & 71.99 \(\pm\) 0.35 \({}^{\text{a}}\) \\ \hline \end{tabular} Abbreviations: Control 1, microcapsules Alg + Pect + Pect + CE; F, microcapsules Alg + Pect + Pect + PE; Control 3, microcapsules Alg + WPI; C, microcapsules Alg + WPI + CE; G, microcapsules Alg + Pect + WPI; D, microcapsules Alg + Pect + WPI + CE; H, microcapsules Alg + Pect + WPI + PE. Results are expressed as mean (n = 3) and SD. Statistically significant differences within a given parameter are marked with different letters (\(p\) < 0.05; Duncan’s test).  
\end{table} 
Table 7: Colorimetric parameters such as lightness (L\({}^{\bullet}\)), green/red (a\({}^{\bullet}\)), yellow/blue (b\({}^{\bullet}\)), saturation (chroma), and color change (\(\Delta\)E) of control microcapsules and those enriched with blueberry fruit extracts. increase in cell proliferation after 7 days of exposure to microcapsules compared to the control in the biocompatibility test with CCD841 CoN cells. Moreover, a prolonged phenotype was demonstrated for cells treated with microcapsules, confirming their low cytotoxicity and no negative effect on their proliferation. In turn, [PERSON] et al. [53] assessed the cytocompatibility of microcapsules (chitosan and cellulose) used for engineering soft and hard tissues and revealed that the free amino groups of chitosan have the most positive effect on the growth of osteoblast cells (CRL-11372). However, in the same study, an increase in the concentration of chitosan was observed; therefore, amino groups can also potentially lead to a higher surface charge, which results in the inhibition of cell viability.