## 3 Results
### Meta-Analysis Results  
Of the 59 studies included in the initial systematic review, those related to trials that included pharmacological treatments were eliminated because of poor numbers of cases. Additionally, all studies that did not include excision with laser or cold-blade scalpel were eliminated. Therefore, only studies that included treatment of oral HPV-related lesions by excision using laser or scalpel were retained for meta-analysis purposes (Figure 2 and Table 13). Figure 2: Flowchart meta-analysis. \begin{table}
\begin{tabular}{c c c c c c c c c} \hline \hline
**Study** & **No of Patients** & \begin{tabular}{c} **Type of** \\ **Lesions** \\ \end{tabular} & \begin{tabular}{c} **Treatment Length/** \\ **No of Application** \\ \end{tabular} & \begin{tabular}{c} **Follow-Up** \\ **(months)** \\ \end{tabular} & **Side Effects** & **Recurrence** & \begin{tabular}{c} **Immunocompromised** \\ **Patients** \\ \end{tabular} & **Healed Lesions** \\ \hline [PERSON] et al., 1990 & 1 & FEH & 1 & 18 & 0 & 0 & 0 & 1 \\ \hline [PERSON] et al., 1992 & 2 & AC & 1 & 23 & 0 & 0 & 0 & 2 \\ \hline [PERSON] et al., 1992 & 11 & SP & 1 & 30 & 0 & 0 & 0 & 11 \\ \hline [PERSON] et al., 1999 & 3 & AC & 2 & 4 & 0 & 3 & 0 & 0 \\ \hline [PERSON] et al., 1999 & 5 & SP & 1 & 3 & 0 & 2 & 0 & 2 \\ \hline [PERSON] et al., 2000 & 1 & FEH & 1 & 20 & 0 & 0 & 0 & 1 \\ \hline [PERSON] 2000 & 1 & SP & 1 & 12 & 0 & 1 & 1 & 0 \\ \hline [PERSON] et al., 2001 & 1 & FEH & 3 & 8 & 0 & 1 & 1 & 0 \\ \hline [PERSON] et al., 2002 & 1 & AC & 3 & 4 & \
\begin{tabular}{c} Malignant \\ transformation \\ \end{tabular} & 1 & 1 & 0 \\ \hline [PERSON] et al., 2003 & 1 & FEH & 1 & 24 & 0 & 0 & 0 & 1 \\ \hline [PERSON] 2003 & 1 & SP & 1 & 36 &
\begin{tabular}{c} Malignant \\ transformation \\ \end{tabular} & 1 & 0 & 0 \\ \hline [PERSON] et al., 2004 & 1 & FEH & 1 & 18 & 0 & 1 & 0 & 0 \\ \hline [PERSON] et al., 2005 & 3 & AC & 1 & 12 & 0 & 0 & 0 & 3 \\ \hline [PERSON] et al., 2007 & 1 & AC & 1 & 6 & 0 & 0 & 0 & 1 \\ \hline [PERSON] et al., 2009 & 1 & Papillomatosis & 6 & 36 & 0 & 0 & 0 & 1 \\ \hline [PERSON] et al., 2009 & 1 & FEH & 1 & 6 & 0 & 0 & 0 & 1 \\ \hline [PERSON] et al., 2010 & 1 & SP & 1 & 6 & Worsening & 1 & 1 & 0 \\ \hline [PERSON] et al., 2011 & 1 & FEH & 1 & 12 & Pain & 1 & 1 & 0 \\ \hline [PERSON] et al., 2012 & 5 & AC & 1 & 2 & 0 & 0 & 5 & 5 \\ \hline Misir 2013 & 1 & SP & 1 & 12 & 0 & 0 & 0 & 1 \\ \hline [PERSON] et al., 2014 & 17 & FEH & 1 & 12 & 0 & 0 & 17 & 17 \\ \hline \hline \end{tabular}
\end{table} 
Table 13: Laser excision studies. \begin{table}
\begin{tabular}{c c c c c c c c c c} \hline \hline
**Study** & **No of Patients** & \begin{tabular}{c} **Type of** \\ **Lesions** \\ \end{tabular} & \begin{tabular}{c} **Treatment Length/** \\ **No of Application** \\ \end{tabular} & \
\begin{tabular}{c} **Follow-Up** \\ **(months)** \\ \end{tabular} & **Side Effects** & **Recurrence** &
\begin{tabular}{c} **Immunocompromised** \\ **Patients** \\ \end{tabular} & **Healed Lesions** \\ \hline Angiero 2015 & 129 & SP & 1 & 12 & 0 & 0 & 0 & 129 \\ \hline Angiero 2015 & 17 & VV & 1 & 12 & 0 & 0 & 0 & 17 \\ \hline Angiero 2015 & 13 & SP & 1 & 12 & 0 & 0 & 0 & 13 \\ \hline Angiero 2015 & 2 & FFH & 1 & 12 & 0 & 0 & 0 & 2 \\ \hline [PERSON] et al., 2018 & 1 & SP & 1 & 1 & 0 & 0 & 0 & 1 \\ \hline [PERSON] et al., 2019 & 12 & SP & 1 & 15 & 0 & 2 & 0 & 10 \\ \hline TOT & 233 & & & & 6 & 12 & 27 & 221 \\ \hline \hline \end{tabular}
\end{table} 
Table 13: _Cent._The results of the meta-analysis of the laser excision studies are summarized in the forest plot in Figure 3. The area of the square is proportional to the weight of the study. To evaluate the presence of heterogeneity, the Higgins I\({}^{2}\) index equal to 16.61%, low heterogeneity, with a p value of 0.268, was used. When heterogeneity occurred, a random-effects model was used. The results show that the pooled proportion was 4.07% (95% CI 0.030-0.182).