## 3 Results
\begin{table}
\begin{tabular}{c c c c c} \hline \hline
**Group** & **Survival Time at** & **Survival Rate, \%** & **Loss of Posture** & **Posture Recovery** \\  & **Altitude, min** & **Survival Rate, \%** & **Time, s** & **Time, s** \\ \hline Control (PBS & & & & \\ intraventricularly) (\(n=12\)) & 3.77 \(\pm\) 0.81 & 33.3\% & 76.83 \(\pm\) 2.56 & 681.3 \(\pm\) 49.52 \\ SRC inhibitor & & & & \\ intraventricularly (\(n=12\)) & 6.68 \(\pm\) 0.84 * & 33.3\% & 76.00 \(\pm\) 2.26 & 738 \(\pm\) 19.43 \\ IKK\(\upbeta\) inhibitor & & & & \\ intraventricularly (\(n=13\)) & 5.16 \(\pm\) 0.64 * & 23.1\% & 77 \(\pm\) 2.44 & 619 \(\pm\) 36.5 \\ \hline \hline \end{tabular}  
* HR—high resistance, MR—medium resistance, LR—low resistance. *—the differences are significant compared to the Control group; \(p\leq 0.05\), one-way ANOVA. Survival time at altitude—F(2,34) = 3.5371, \(p=0.0402\); Bonferroni post-hoc test revealed significant differences between the following groups: Control vs. SRC \(p=0.0356\). Loss of posture time—no statistically significant differences, F(2,34) = 0.1414, \(p=0.8686\), Posture recovery time—no statistically significant differences, F(2,8) = 1.2525, \(p=0.3363\), Survival rate—no statistically significant differences, \(p=0.8138\) (a long-rank Mantel-Cox test).  
\end{table} 
Table 2: The main parameters of animal resistance to acute hypobaric hypoxia. Figure 3: The influence of inhibition of the studied kinases on the distribution of animals according to the degree of resistance to hypoxia, %. We analyzed the memory traces within the reproduction of navigation learning in the Morris water maze. The results of animal training in the Morris maze are shown in Supplementary Figure S1. Our research has shown that ischemia decreases the spatial learning abilities of mice. There were no mistakes in the Intact group during the training in the maze since the third session. In the Ischemia group, two animals failed one attempt to find the hidden platform on the third learning session and one attempt to find the hidden platform on the fifth learning session. In the SRC inhibitor\" group there were no failed attempts on the fourth and fifth session. In the IKK\(\beta\) inhibitor group, two animals had a wrong attempt on the third learning session and one animal failed on the fourth and fifth learning sessions. It was shown that the delayed coefficient of memory retention in the Control group after ischemia was significantly decreased compared to intact animals (Intact--42.62 \(\pm\) 1.12, Control--29.48 \(\pm\) 2.15). IKK\(\beta\) inhibitor treatment also led to the delayed coefficient of memory retention decreasing. In SRC kinase blockade, the values of the delayed coefficient of retention did not differ from the Intact group (Table 3). Figure 4: The main parameters of the locomotor and orientation-exploratory activity of animals 24 h after the AHH modeling against the background of intraventricular administration of kinase inhibitors. “Intact” n = 6, “Control” n = 4, “SRC” n = 4, “Ikk\(\beta\)” n = 3, “—the differences are significant compared to the Intact group, \(p\leq\) 0.05, one-way ANOVA was followed by Bonferroni post-hoc test for multiple comparisons. (**A**)—Time in the center—F(3,13) = 3.4099; \(p\) = 0.05, Bonferroni post-hoc test revealed significant differences between the following groups: Intact vs. Control \(p\) = 0.0448, (**B**)—Distance in the center—F(3,13) = 3.5714; \(p\) = 0.0441, (**C**)—Total distance, no statistically significant differences, F(3,13) = 0.0864, \(p\) = 0.9663; (**D**)—Number of stances, no statistically significant differences, F(3,13) = 1.3393, \(p\) = 0.3044. Figure 5: The main parameters of the locomotor and orientation-exploratory activity of animals 24 h after ischemia modeling against the background of intraventricular administration of kinase inhibitors.