## 4 Conclusions  
In summary, we report a total synthesis strategy for surfactant-mimetic nanocolloids (SMNCs) via regioselective silica deposition on engineered linear-block-brush bottlebrush polymers (PCNB-b-P (NB-PSt)). The resulting SMNCs feature a well-defined silica nanoparticle head (~5 nm) and a programmable bottlebrush polymer tail, as confirmed by SEM and TEM. Furthermore, these SMNCs exhibit typical amphiphilic characteristics and self-assemble into compound micelles (~214 nm) in methanol. This synthesis strategy is versatile, enabling the fabrication of other molecular-mimetic nanocolloids (GMNCs) (e.g., dumbbell-shaped structures using linear-_block_-brush-_block_-linear bottlebrush polymers), and adaptable to MMNCs with different nanoparticle lobes, such as metal oxides (e.g., Fe\({}_{3}\)O\({}_{4}\)) [48]. The structural precision of SMNCs holds potential for applications including emulsion stabilization, targeted drug delivery, and hierarchical assembly structures. For instance, amphiphilic SMNCs can serve as efficient Pickering stabilizers, outperforming molecular surfactants under harsh conditions (e.g., extreme pH) [49]. The ultrasmall silica lobes enable drug loading [50], while the brush tails provide enhanced functionality and reactive sites. Asymmetric single-molecule nanocolloids can potentially direct the assembly of superlattices through oriented interactions between the silica lobes and polymer tails [51]. Our strategy paves the way for a new class of MMNCs and MMNC-based materials.  
The following supporting information can be downloaded at [[https://www.mdpi.com/article/10.3390/app15158766/s1](https://www.mdpi.com/article/10.3390/app15158766/s1)]([https://www.mdpi.com/article/10.3390/app15158766/s1](https://www.mdpi.com/article/10.3390/app15158766/s1)): Figure S1: Synthesis routes of macromolecular norbornene-terminated polystyrene; Figure S2: 1H NMR spectra of NB-OH, NB-Br and NB-PSt\({}_{25}\); Figure S3: GPC traces of NB-PSt\({}_{h}\); Figure S4: GPC traces of NB-PSt, PiBNB, as-synthesized PfBNB-\(b\)-P (NB-PSt), purified PfBNB-\(b\)-P (NB-PSt) and hydrolyzed PCNB-\(b\)-P (NB-PSt); Figure S5: TGA thermograms of SMNCs and BBPs, respectively. Table S1: The structural parameters of macromolecular NB-PSt\({}_{h}\); Table S2: The structural parameters of bottlebrush polymers.  
Figure 4: (**a**) SEM image of SMNC micelles. (**b**) The size distribution of SMNC micelles. The data are presented as statistical analysis from SEM images (orange columns) and DLS results for the micelle solution in methanol (red circles) (\(D_{\text{h}}\) = 272.6 \(\pm\) 2.6 nm, PDi = 0.063) and SMNCs in THF (blue triangles) (\(D_{\text{h}}\) = 63.7 \(\pm\) 0.3 nm, PDi = 0.132). (**c**) Magnified SEM image of a single micelle, highlighted by the dashed-line box in (**a**). (**d**) A schematic illustration of the compound micelle.  
**Author Contributions:** Conceptualization, C.Y.; methodology, L.L. and C.Y.; validation, L.L.; formal analysis, L.L. and C.Y.; investigation, J.Z., L.L. and L.A.; data curation, J.Z. and L.L.; writing--original draft preparation, L.A. and C.Y.; writing--review and editing, C.Y.; visualization, H.Z.; supervision, K.S. and C.Y.; project administration, C.Y.; funding acquisition, C.Y. All authors have read and agreed to the published version of the manuscript.  
**Funding:** This work was supported by Natural Science Foundation of Sichuan Province (2023 NS-FSC0314) and the Fundamental Research Funds for the Central Universities.  
**Institutional Review Board Statement:** Not applicable.  
**Informed Consent Statement:** Not applicable.  
**Data Availability Statement:** The original contributions presented in this study are included in the article. Further inquiries can be directed to the corresponding author.  
**Conflicts of Interest:** The authors declare no conflicts of interest.