# Towards Understanding the Function of Aegerolysins
## 4 Aegerolysin Binary Partner Proteins
\begin{table}
\begin{tabular}{c c c c c c c c c} \hline \hline \multirow{2}{*}{**Short Name**} & **Aegerolysin/ Structure** & **Membrane Receptor** & **Function** &
\begin{tabular}{c} **Partner Protein/** \\ **Photein** \\ **Short Name** \\ \end{tabular} & **Partner Protein/ Structure** & **Organism** & **Reference** \\ \hline \multirow{4}{*}{**Asp-HS**} & \multirow{4}{*}{Asp-hemolysin} & \multirow{4}{*}{Oxidized low-density} & \multirow{4}{*}{**Function**} & **AfpT-1B** & **AfpT-2C** & **Apergillus** & \multirow{4}{*}{**Apergillus**} & \multirow{4}{*}{**[107, 108, 109, 110, 111, 112, 113, 114, 115]} \\  & & & & **Apergillus** & & & & \\  & & & & **Apergillus** & & & & \\  & & & & & & & & \\ \hline
**Asp-HS-like** & Asp & \multirow{4}{*}{n.d.} & \multirow{4}{*}{n.d.} & \multirow{4}{*}{No} & \multirow{4}{*}{No} & \multirow{4}{*}{_Apergillus_} & \multirow{4}{*}{[114]} \\  & & & & & & & & \\  & & & & & & & & \\ \hline
**NigA1** & Nigerolysin A1 & n.d. & n.d. & No & No & & & \\  & & & & & & & & \\ \hline
**NigA2** & Nigerolysin A2 & CPE/Chol & n.d. & **NigB1** & Nigerolysin B1 &
\begin{tabular}{c} _Apergillus_ \\ _niger_ \\ \end{tabular} & [91, 92] \\ \hline
**Ter** & Terrelysin & n.d. & n.d. & No & No & & & \\ \hline
**AoHlyA** &
\begin{tabular}{c} _Apergillus oryzae_ \\ hemolysin \\ \end{tabular} & n.d. & n.d. & No & No & & \\ \hline
**BlyA** & Beauveriolysin A & \
\begin{tabular}{c} SM/Chol \\ CPE/Chol \\ \end{tabular} & n.d. & **BlyB** & Beauveriolysin B &
\begin{tabular}{c} _Beunveria_ \\ _basiana_ \\ \end{tabular} & [52] \\ \hline
**Agli1** & \begin{tabular}{c} _Trichoderma_ \\ _atroviatile_ \\ aegerolysin \\ \end{tabular} & \
\begin{tabular}{c} Conidation \\ Antagonism \\ \end{tabular} & n.d. & No & No &
\begin{tabular}{c} _Trichoderma_ \\ _atroviatile_ \\ \end{tabular} & [128] \\ \hline
**L152** & \
\begin{tabular}{c} _Alternaria giesen_ \\ aegerolysin \\ \end{tabular} & n.d. & n.d. & **L152B** & n.d. &
\begin{tabular}{c} _Alternaria_ \\ _giesen_ \\ \end{tabular} & [36] \\ \hline
**Cry34 Ab1** & \begin{tabular}{c} 13.6 kDa \\ Insecicidal \\ crystal protein \\ PDB ID: 4 JOX \\ \end{tabular} & \begin{tabular}{c} Unknown \\ protein \\ receptor \\ \end{tabular} & \begin{tabular}{c} Insecicidal \\ (+Cry34 Ab1) \\ \end{tabular} & \begin{tabular}{c} **Cry35 Ab1** \\ **(Trp35 Ab1)** \\ \end{tabular} & \
\begin{tabular}{c} **A3.8 kDa** \\ insecticicidal crystal \\ protein \\ PDB ID: 4 JPO \\ \end{tabular} &
\begin{tabular}{c} _Bacillus_ \\ _huringiensis_ \\ \end{tabular} & [39, 129, 130, 131, 132, 133, 134, 135, 136] \\ \hline
**Cbm17.1** & Hemolysin-like protein Cbm17.1 & n.d. & \begin{tabular}{c} Insecicidal \\ (+Cry16 Aa/ \\ Cry17 Aa/ \\ Cbm17.2) \\ \end{tabular} & \begin{tabular}{c} **Cry16 Aa,** \\ Cry17 Aa,** \\ Cbm17.2) \\ \end{tabular} & \
\begin{tabular}{c} **Cry16 Aa and** \\ Cry17 Aa,** \\ Cry17 Aa,** \\ protein Cbm17.2 \\ \end{tabular} &
\begin{tabular}{c} **Cry16 Aa and** \\ Cry17 Aa,** \\ _bifermetants_ \\ \end{tabular} & [40, 140, 142] \\ \hline
**Cbm17.2** & Hemolysin-like protein Cbm17.2 & n.d. & \begin{tabular}{c} Insecicidal \\ (+Cry16 Aa/ \\ Cry17 Aa/ \\ Cbm17.1) \\ \end{tabular} & \begin{tabular}{c} **Cry16 Aa,** \\ Cry17 Aa,** \\ Hemolysin-like \\ protein Cbm17.1 \\ \end{tabular} & \
\begin{tabular}{c} **Cry16 Aa and** \\ Cry17 Aa,** \\ Hemolysin-like \\ protein Cbm17.1 \\ \end{tabular} &
\begin{tabular}{c} **Cry16 Aa,** \\ Cry17 Aa,** \\ _bifermetants_ \\ \end{tabular} & [40, 140, 142] \\ \hline
**AfIP-1A** & \begin{tabular}{c} Two-component \\ insectical protein \\ 16 kDa unit \\ PDB ID: 5V3S \\ \end{tabular} & \begin{tabular}{c} Unknown \\ protein receptor \\ \end{tabular} & n.d. & **AfIP-1B** & \
\begin{tabular}{c} Two-component \\ insecticidal protein \\ 77 kDa unit \\ \end{tabular} &
\begin{tabular}{c} _Alcaligenes_ \\ _facalis_ \\ \end{tabular} & [143, 144] \\ \hline
**RahU** & \
\begin{tabular}{c} RahU protein \\ PDB ID: 6 ZC1 \\ \end{tabular} & CPE/Chol & n.d. & No & No &
\begin{tabular}{c} _Pseudomonas_ \\ _aerginosa_ \\ \end{tabular} & [145, 148] \\ \hline
**P23** & n.d. & n.d. & n.d. & No & No &
\begin{tabular}{c} _Pseudoplasma_ \\ _includes_ \\ \end{tabular} & [48] \\ \hline
**TnAV2 cgp029** & n.d. & n.d. & n.d. & No & No &
\begin{tabular}{c} _Trichophilia_ \\ _in asovirus_ \\ \(2c\) \\ \end{tabular} & [49, 50, 149, 150, 152] \\ \hline \hline \end{tabular}
\end{table}