## 2 Materials and Methods
### Synthesis of Chalcone Derivatives
Mp = 158-160 \({}^{\circ}\)C. IR (ATR diamond, cm\({}^{-1}\)) = 3051 (C-H), 2920 (C-H), 1644 (C=O), 1024 (C-O) cm\({}^{-1}\). \({}^{1}\)H NMR (400 MHz, CDCl\({}_{3}\)) \(\delta\): 8.22 (dd, \(J_{1}\) = 7.9, \(J_{2}\) = 1.5 Hz, 1H, H5), 7.87 (dd, \(J_{1}\) = 9 Hz, 2H, H2\({}^{\prime}\), H6\({}^{\prime}\)), 7.69 (ddd, \(J_{1}\) = 8.5, \(J_{2}\) = 8.7, \(J_{3}\) = 1.7 Hz, 1H, H7), 7.54 (ddd, \(J_{1}\) = 8.4 Hz, 1H, H8), 7.41 (ddd, \(J_{1}\) = 8.0, \(J_{2}\) = 8.0, \(J_{3}\) = 1.0 Hz, H6), 7.02 (dd, \(J_{1}\) = 9 Hz, 2H, H3\({}^{\prime}\), H5\({}^{\prime}\)), 6.73 (s, 1H, H3), 3.87 (s, 3H, H11). \({}^{13}\)C NMR (100 MHz, CDCl\({}_{3}\)) \(\delta\): 178.4 (s, C4), 163.5 (s, C2), 162.5 (s, C4\({}^{\prime}\)), 156.3 (s, C9), 133.6 (d, C7), 128.1 (d, C2\({}^{\prime}\), \(C6^{\prime}\)), 125.7 (d, C5), 125.1 (d, C6), 124.1 (s, C10), 124.0 (s, C1\({}^{\prime}\)), 118.0 (d, C8), 12-(3,4-dimethoxyyphenyl)-4H-chromen-4-one (**3**g**): white powder (yield 85%). C\({}_{17}\)H\({}_{14}\)O\({}_{4}\). Mp = 128-130 \({}^{\circ}\)C. IR (ATR diamond, cm\({}^{-1}\)) = 3062 (C-H), 2929 (C-H), 1651 (C=O), 1144 (C-O) cm\({}^{-1}\). \({}^{1}\)H NMR (400 MHz, CDCl\({}_{3}\)) \(\delta\): 8.23 (dd, \(J_{1}\) = 7.9, \(J_{2}\) = 1.5 Hz, IH, H5), 7.70 (ddd, \(J_{1}\) = 8.5, \(J_{2}\) = 8.6, \(J_{3}\) = 1.7 Hz, 1H, H7), 7.57 (ddd, \(J_{1}\) = 8.4, \(J_{2}\) = 1.9 Hz, 2H, H8, H2\({}^{\prime}\)), 7.42 (ddd, \(J_{1}\) = 8.0, \(J_{2}\) = 7.6, \(J_{3}\) = 1.0 Hz, 1H, H6), 7.39 (ddd, 1H, H6\({}^{\prime}\)), 6.99 (d, 1H, H3\({}^{\prime}\)), 6.77 (s, 1H, H3), 3.98 (s, 3H, H11), 3.96 (s, 3H, H12). \({}^{13}\)C NMR (100 MHz, CDCl\({}_{3}\)) \(\delta\): 193.7 (s, C4), 163.6 (s, C2), 151.9 (s, C9), 149.4 (s, C5\({}^{\prime}\)), 145.7 (s, C4\({}^{\prime}\)), 136.2 (d, C7), 129.6 (d, C5), 127.7 (s, C10), 123.6 (d, C6), 121.6 (s, C1\({}^{\prime}\)), 120.2 (d, C2\({}^{\prime}\)), 118.8 (d, C8), 117.9 (d, C3\({}^{\prime}\)), 111.3 (d, C6\({}^{\prime}\)), 110.5 (d, C3), 56.1 (q, C11, C12). GC-MS m/z (rel. int.) = 282.18 [M]\({}^{+}\) (35), 168.13 (12), 147.11 (16), 127.18 (25), 121.08 (100), 119.05 (32), 92.07 (86), 91.09 (99), 76.08 (91). 2-(4-chlorophenylophenyl)-4H-chromen-4-one (**3**h**): white powder (yield 82%). C\({}_{15}\)H\({}_{9}\)ClO\({}_{2}\). Mp = 188-190 \({}^{\circ}\)C. IR (ATR diamond, cm\({}^{-1}\)) = 3071 (C-H), 1647 (C=O), 756 (C-Cl) cm\({}^{-1}\). \({}^{1}\)H NMR (400 MHz, CDCl\({}_{3}\)) \(\delta\): 8.23 (dd, \(J_{1}\) = 7.9, \(J_{2}\) = 1.4 Hz, IH, H5), 7.86 (dd, \(J_{1}\) = 8.8 Hz, 2H, H3\({}^{\prime}\), H5\({}^{\prime}\)), 7.71 (ddd, \(J_{1}\) = 8.5, \(J_{2}\) = 8.7, \(J_{3}\) = 1.7 Hz, 1H, H7), 7.55 (ddd, \(J_{1}\) = 8.4, \(J_{2}\) = 1.0 Hz, IH, H8), 7.50 (dd, \(J_{1}\) = 8.8 Hz, 2H, H2\({}^{\prime}\), H6\({}^{\prime}\)), 7.43 (ddd, \(J_{1}\) = 8.0, \(J_{2}\) = 7.8, \(J_{3}\) = 1.0 Hz, IH, H6), 6.77 (s, 1H, H3). \({}^{13}\)C NMR (100 MHz, CDCl\({}_{3}\)) \(\delta\): 178.2 (s, C4), 162.3 (s, C2), 156.2 (s, C9), 138.0 (d, C7), 134.0 (s, C4\({}^{\prime}\)), 130.3 (d, C2\({}^{\prime}\), C6\({}^{\prime}\)), 129.4 (d, C3\({}^{\prime}\), C5\({}^{\prime}\)), 127.6 (s, C1\({}^{\prime}\)), 125.8 (d, C5), 125.4 (s, C10), 124.0 (d, C6), 118.1 (d, C8), 107.8 (d, C3). GC-MS m/z (rel. int.) = 258.18 [M]\({}^{+}\) (3), 256.18 (10), 228.16 (6), 165.18 (3), 136.13 (13), 120.12 (29), 101.13 (28), 92.11 (100). 2-(4-(dimethylamino)phenyl)-4H-chromen-4-one (**3**i**): white powder (yield 67%). C\({}_{17}\)H\({}_{15}\)NO\({}_{2}\). Mp = 193-195 \({}^{\circ}\)C. IR (ATR diamond, cm\({}^{-1}\)) = 3057 (C-H), 1659 (C=O), 1277 (C-N) cm\({}^{-1}\). \({}^{1}\)H NMR (400 MHz, CDCl\({}_{3}\)) \(\delta\): 8.17 (dd, \(J_{1}\) = 8.8, \(J_{2}\) = 2 Hz, 1H, H5), 80.4-7.78 (m, 3H, H6, H7, H8), 7.77 (dd, 2H, H3\({}^{\prime}\), H5\({}^{\prime}\)), 6.94 (dd, 2H, H2\({}^{\prime}\), H6\({}^{\prime}\)), 6.84 (s, 1H, H3), 2.99 (s, 6H, H11).