## 2 New Techniques, Materials and Technologies in Dentistry  
All patients are different, so the \"one size fits all\" approach to prevention, diagnosis and treatment is evolving into a more personalized concept of medicine. Better knowledge of patients' genetic profile can help guide clinical decisions. An example of this is peripimdentis, a growing problem that requires better approaches in terms of prevention and treatment. [PERSON] et al. [1] carried out a systematic review via a meta-analysis with the aim of evaluating the association between IL-1A, IL-1B and IL-1 RN polymorphisms and peripimdentis. The results showed that patients who have the polymorphic allele at position +3954 of the IL-1B gene have on average almost twice the risk of developing peri-implantitis. In the area of disease diagnosis, the use of biomarkers can enable timely diagnosis and better monitoring of disease progression and response to treatment. In an innovative study, [PERSON] et al. [2] evaluated salivary interleukin-6, interleukin-1B and C-reactive protein as a diagnostic tool for plaque-induced gingivitis in children. Based on the results, the authors suggest that salivary IL-1B and CRP can be used as potential diagnostic tools to differentiate between moderate and severe plaque-induced gingivitis. In another field, [PERSON] et al. [3] tested the potential use of salivary nitric oxide as a biomarker of bone response following the application of different types of orthodontic appliances. The results showed that metal brackets lead to a significant temporary increase in oral oxidative stress as an adaptive reaction to the presence of foreign bodies in the oral cavity. Conventional prevention and treatment strategies of caries, periodontal and periimplant diseases present some limitations, making it necessary to search for alternatives or adjuurants. Probiotics may play an important role in this context. [PERSON] et al. [4] carried out a systematic review on the use of probiotics in the prevention and treatment of oral diseases, supporting the existing evidence in this regard. In relation to novel therapeutic approaches, the effect of passive ultrasonic irrigation on the elimination of organic remnant tissue from infected, narrow and curved mandibular root canals during their instrumentation was evaluated in an in vitro study by [PERSON] et al. [5]. The results suggest that clinicians should incorporate passive ultrasonic irrigation in their regular therapeutic strategy. Several articles focused on the use of digital technologies in dentistry. This area has seen extremely rapid development in recent years, with a strong impact on clinical practice. For instance, digital technologies bring several advantages, such as reducing errors and complications, faster treatments and faster patient recovery. [PERSON] et al. [6] evaluated the advantages of dynamic navigation in prosthetic implant treatment in terms of clinical results and salivary pro-inflammatory biomarkers. Dynamic navigation and the application of the flapless technique reduced surgical trauma, leading to a reduced risk of infection, reduced patient discomfort and faster recovery. Implant stability is critical in implant therapy, and there are several devices on the market that allow it to be assessed through resonance frequency analysis and the implant stability coefficient to be calculated. However, there are few studies that have compared the reliability and agreement of different devices. In an in vitro study, [PERSON] et al. [7] compared inter- and intra-rater reliability and the agreement level among three of these devices. [PERSON] et al [8] carried out a systematic review on the use of bisphosphonates and implant failure, also identifying other factors such as smoking, poor hygiene, diabetes and hypertension, which increase the risk of failure. In prosthetic procedures, digital techniques have assumed an increasingly relevant role. Intraoral scanners have gained great clinical acceptance and undergone constant improvements in recent years.