## 3 Results
### Prevalence of Efflux Pump and Regulatory Genes

Table 3: Distribution of efflux pump genes, outer membrane proteins, and resistance patterns of MDR _P. aeruginosa_ isolates. \begin{table}
\begin{tabular}{c c c c c c c c c c c c c c c c c c c c c} \hline \hline
**Antibiotics** & \multicolumn{2}{c}{**MexA**} & \multicolumn{2}{c}{**MexB**} & \multicolumn{2}{c}{**OprM**} & \multicolumn{2}{c}{**MexC**} & \multicolumn{2}{c}{**MexD**} & \multicolumn{2}{c}{**OprJ**} & \multicolumn{2}{c}{**MexX**} & \multicolumn{2}{c}{**MexY**} & \multicolumn{2}{c}{**OprN**} \\ \hline  & **P** & **N** & **P** & **N** & **P** & **N** & **P** & **N** & **P** & **N** & **P** & **N** & **P** & **N** & **P** & **N** & **P** & **N** & **P** & **N** \\  & **(n)** & **(n)** & **(n)** & **(n)** & **(n)** & **(n)** & **(n)** & **(n)** & **(n)** & **(n)** & **(n)** & **(n)** & **(n)** & **(n)** & **(n)** & **(n)** & **(n)** & **(n)** & **(n)** \\ \hline
**Cefazidime** & 43 & 2 & 45 & 0 & 43 & 2 & 45 & 0 & 33 & 12 & 27 & 18 & 40 & 5 & 0 & 45 & 21 & 24 \\
**Aztreonam** & 22 & 2 & 24 & 0 & 23 & 1 & 24 & 0 & 15 & 9 & **11** & **13** & **21** & 3 & 0 & 24 & 14 & 10 \\
**Meropenem** & 38 & 2 & 40 & 0 & 39 & 1 & 40 & 0 & 30 & 10 & 27 & 13 & 35 & 5 & 0 & 40 & 22 & 18 \\
**Imipenem** & 5 & 0 & 5 & 0 & 4 & 1 & 5 & 0 & 4 & 1 & 3 & 2 & 5 & 0 & 0 & 5 & 2 & 3 \\
**Gentamicin** & 43 & 2 & 45 & 0 & 44 & 1 & 45 & 0 & 32 & 13 & 27 & 18 & 40 & 5 & 0 & 45 & 26 & 19 \\
**Tobramycin** & 10 & 2 & 12 & 0 & 12 & 0 & 12 & 0 & 9 & 3 & 9 & 12 & 0 & 0 & 12 & 6 & 6 \\
**Amikacin** & 53 & 0 & 53 & 0 & 53 & 0 & 53 & 0 & 52 & 1 & 52 & 1 & 52 & 1 & 0 & 53 & 52 & 1 \\
**Ciprofloxacinacin** & 31 & 2 & 33 & 0 & 32 & 1 & 33 & 0 & 24 & 9 & 29 & 4 & 29 & 4 & 0 & 33 & 23 & 10 \\
**Levofloxacin** & 43 & 0 & 43 & 0 & 41 & 2 & 43 & 0 & 33 & 10 & 38 & 5 & 38 & 5 & 0 & 43 & 23 & 20 \\
**Norfloxacin** & 12 & 0 & 12 & 0 & 11 & 1 & 12 & 0 & 7 & 5 & 10 & 2 & 10 & 2 & 0 & 12 & 7 & 5 \\ \hline \hline \end{tabular}
\end{table} 
Table 4: Efflux pumps genes and antibiotics resistance of _P. aeruginosa_ isolates isolates. \begin{table}
\begin{tabular}{c c c c c c c c c c c c} \hline \hline
**Isolates** & **MexA** & **MexB** & **OprM** & **MexC** & **MexD** & **OprJ** & **MexX** & **MexY** & **OprN** & **Resistance Pattern** \\ \hline J24 & + & + & + & + & + & + & + & \(-\) & \(-\) & \(-\) & CIP-AK-LEV-CAZ \\ J25 & + & + & + & + & + & + & + & \(-\) & \(-\) & \(-\) & CIP-AK-CAZ \\ J26 & + & + & + & + & \(-\) & \(-\) & \(+\) & \(-\) & \(-\) & \(-\) & GM-AK-LEV-MEM-ATM \\ J27 & + & + & + & + & \(-\) & \(-\) & \(+\) & \(-\) & \(+\) & \(-\) & \(+\) & GM-CIP-AK-LEV-NOR-CAZ-MEM-ATM \\ J28 & + & + & + & + & + & + & + & \(-\) & \(-\) & \(-\) & \(-\) & GM-CIP-AK-LEV-CAZ-MEM \\ J29 & + & + & + & + & + & + & + & \(-\) & \(-\) & \(-\) & GM-CIP-AK-LEV-CAZ-MEM \\ J30 & + & + & + & + & + & + & + & \(-\) & \(-\) & \(-\) & GM-CIP-AK-LEV-CAZ \\ J31 & + & + & + & + & + & + & + & \(-\) & \(-\) & \(-\) & GM-CIP-AK-LEV-NOR-CAZ-MEM \\ J32 & + & + & + & + & + & \(-\) & \(+\) & \(-\) & \(-\) & \(+\) & GM-CIP-MEM-TOB \\ J33 & + & + & + & + & + & + & + & \(-\) & \(-\) & \(-\) & GM-CIP-AK-LEV-NOR-MEM \\ J33 & + & + & + & + & + & + & + & \(-\) & \(-\) & \(+\) & GM-CIP-AK-LEV-CAZ-MEM-TOB \\ J41 & + & + & + & + & + & + & + & \(-\) & \(+\) & \(-\) & \(+\) & GM-CIP-AK-LEV-CAZ-MEM-ATM \\ J42 & + & + & + & + & + & \(-\) & \(-\) & \(-\) & \(-\) & \