); [EMAIL_ADDRESS] (S.-G.K.) Department of Biotechnology, Alagappa University, Science Campus, Karaikudi, Tamil Nadu 630003, India; [EMAIL_ADDRESS] (R.M.B.S. ); [EMAIL_ADDRESS] (S.A.L.) Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel  
4 Correspondence: [EMAIL_ADDRESS]  
[PERSON]  
3 Department of Food Engineering, Mokpo National University, Muan, Jeonnam 534-729, Korea; [EMAIL_ADDRESS] (Y.-K.P. ); [EMAIL_ADDRESS] (K.-S.H. ); [EMAIL_ADDRESS] (S.-G.K.) Department of Biotechnology, Alagappa University, Science Campus, Karaikudi, Tamil Nadu 630003, India; [EMAIL_ADDRESS] (R.M.B.S. ); [EMAIL_ADDRESS] (S.A.L.) Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel  
4 Correspondence: [EMAIL_ADDRESS]  
[PERSON]  
3 Department of Food Engineering, Mokpo National University, Muan, Jeonnam 534-729, Korea; [EMAIL_ADDRESS] (Y.-K.P. ); [EMAIL_ADDRESS] (K.-S.H. ); [EMAIL_ADDRESS] (S.-G.K.) Department of Biotechnology, Alagappa University, Science Campus, Karaikudi, Tamil Nadu 630003, India; beema. with peels of two kiwifruit's significantly reduced total cholesterol and triglycerides, and increased the high-density lipoprotein levels in rats [6]. The kiwifruit flour was used for food formulations, and the contents of free phenolics and antioxidant capacities were significantly higher than those of other investigated samples [7]. It was reported that kiwifruit is consumed in many forms such as fresh, flour, juice, vinegar, dried slices, jam, wine, yogurt, and jelly [6; 7; 8; 9; 10]. Despite limited absorption and digestion, dietary polyphenols have shown many health-promoting effects [11]. The investigations proved that kiwifruit's with high amounts of health-beneficial metabolites, including polyphenols and vitamin C, which are the main compounds, also possess pharmacological properties [6; 8; 12]. Persimmon possesses high nutritional properties, containing organic acids, phenolic compounds, carotenoids, and tannins as its main nutrients [4; 5]. Such composition determines antioxidant, cytotoxic, and antidiabetic activities, where some of them, related to human health, are attributed directly to tannins and gallic acid. The indices of recovery and bioaccessibility of phenols and flavonoids during gastrointestinal digestion in samples of persimmon flour were evaluated in vitro [13; 14; 15; 16]. Persimmon in the same way as kiwifruit is used in different forms such as fresh, dry and flours [8; 17]. As it was mentioned previously, kiwifruit 'Hayward' is one of the most popular in the international scale, as well as persimmon 'Fuyu'. These traditional cultivars are main income fruits in Korea, and consumption of these fruits is consistently higher compared to pear, peach and grapes [1; 2; 18]. Kiwifruit 'Bidan' and 'Cheongsan' are new cultivars, introduced recently in Korea [3; 19; 20]. As it was cited in the recent literature there are many reports showing the properties of kiwifruit and persimmon, but two new kiwifruit cultivars are rarely compared by their nutritional and functional properties. ADH and DKF [19; 20] are the most popular cultivars in comparison with the new ones AAC and AEB [3]. The comparison of the overall properties of the most popular kiwifruit and persimmon cultivars with two new ones will advance their industrialization. There are few reports about the biophysical interaction of polyphenols in the investigated fruits, as well as the correlation between phenolic, antioxidant and binding properties [16; 21]. In spite of such wide scientific information it is a lack of medicinal properties of the investigated fruits, based on interaction of polyphenols with human serum albumin (HSA), the main carrier of drugs in human metabolism. These fruits have already been reported for several health benefits. Nonetheless, the study with their bioactive ingredients/ligands is very scanty.