## 1 Introduction  
The oral administration of drugs through conventional dosage forms such as capsules, lozenges, and tablets, among others, presents limitations when used in geriatric, pediatric,dysphagic, psychiatric, and even animal patients [1]. One of the primary causes of these limitations is neuromuscular changes; however, they can also occur in patients with neurocognitive disorders [2]. Studies evaluating dysphagia have documented a prevalence of approximately 30% in individuals over 65 years of age who are hospitalized, leading to its classification as a new geriatric syndrome. Additionally, dysphagia is estimated to affect 50% of elderly residents in nursing homes and more than 40% of patients who have suffered strokes [2]. In the clinic, the need for this type of method of administration arises due to there being patients, such as babies or elderly people, with problems swallowing pills or capsules. Thus, there is a necessity to develop edible films that can release and deliver a hydrophilic drug quickly and a need for orodispersible dosage forms to demonstrate their ability to overcome these limitations. One promising alternative is orally disintegrating films (ODFs), which are polymer-based, thin (thickness ranging from >10 um to <750 um) [3], flexible, easy to administer, and stable during preparation, packaging, and transportation [1; 2; 3; 4]. ODFs are generally composed of water-soluble polymers, plasticizers, and a pharmaceutical ingredient. Upon hydration, they adhere to the oral mucosa and release the drug for transmucosal or local therapy. This offers several advantages over conventional oral administration, primarily due to the high vascularization of the mucosa, which enables faster drug absorption. This improves bioavailability while preventing enzymatic degradation in the gastrointestinal tract and avoiding first-pass metabolism [5]. Additionally, the accessibility of the oral cavity and buccal mucosa facilitates the application and removal of drug delivery systems, making them convenient for both patients and caregivers. However, continuous saliva flow, as well as tongue and jaw movements, can limit their effectiveness. Furthermore, the permeability of the oral mucosa is lower than that of the small intestine, although this limitation can be mitigated by prolonged retention times [6]. There are two types of oral films: orodispersible ones that aim for rapid dissolution and bioadhesiveness that allows high solubility and absorption, leading to bioavailability of the drug [7], on the one hand, and mucoadhesive films that are intended for application on the oral mucosa, allowing controlled release of the active ingredient over an extended period. Therefore, the polymer matrix responsible for transporting the active ingredient must integrate the characteristics of multiple compounds to enhance its application. The intrinsic properties of the polymers constitute a fundamental part of the synergy of the formulations. Biopolymers based on polysaccharides play a fundamental role due to the ability to form films in the presence of plasticizers and the organoleptic properties that they provide to the matrix-drug system. Among the biopolymers used in the process of formulating edible films from solutions, starch and chitosan have been extensively studied. Optimal ratios of 1.5:1 (starch-chitosan) have been identified, yielding excellent mechanical properties by balancing the flexibility of thermoplastic starch (TPS) with the rigidity of chitosan, due to the 1.5:1 relation showed an elongation of 61.1% [8], while [PERSON]. [PERSON] et al. showed that the tensile strength is increased due to the addition of the chitosan to the blend. With rice starch, the best radios were 1:1 and 0.5:1 (starch-chitosan) with a 36 MPa and 38 MPa, respectively [9]. Also, [PERSON] et al. determined that the E value of a blend of chitosan-starch increases due to the hydrogen bonds between NH\({}_{3}\)+ protonated from chitosan and the OH of the starch [10].