## 5 Potential Indications, Advantages, and Disadvantages of LIE-CT in Clinical Practice  
Given the promising results observed in the literature, we aim to provide readers with a concise overview of the main clinical applications, advantages, and disadvantages of LIE-CT. In the acute setting, LIE-CT scanning could be integrated into the protocol for patients presenting with chest pain at low to intermediate risk for acute coronary syndrome requiring coronary CT angiography. An LIE-CT scan, indeed, aims to identify potential cases of acute myocarditis, Takotsubo cardiomyopathy, and myocardial infarction with non-obstructed coronary arteries, as proposed by [PERSON] et al. [38]. However, their study demonstrated the slight underestimation of the scar extension compared to LGE-CMR. Nonetheless, LIE-CT remains a valuable tool in acute scenarios. In non-acute settings, LIE-CT may assist in identifying myocardial scars in patients with contraindications to magnetic resonance imaging or those unable to undergo prolonged scans. This aids in diagnosis based on the location and distribution patterns of the myocardial enhancement in both ischemic and non-ischemic conditions, albeit with lower sensitivity compared to LGE-CMR.  
Among the main advantages of LIE-CT are its wide availability (especially in the acute setting), short scan times with optimized protocols allowing for minimal contrast agent and ionizing radiation exposure, and the ability to perform the exam in patients with contraindications to CMR. Among the major disadvantages are the use of ionizing radiation, the unsuitability for patients with contraindications to iodinated contrast media,  
\begin{table}
\begin{tabular}{c c c} \hline \hline \multirow{2}{*}{**Pathology**} & **Authors Investigating** & \multirow{2}{*}{**Typical Pattern**} \\  & **LIE-CT’s Role** & \\ \hline \multirow{6}{*}{Myocardial infarction} & [PERSON] et al. [6] & \\  & [PERSON] & \\  & et al. [17; 21] & \\  & [PERSON] et al. [14] & \\  & [PERSON] et al. [20] & \\  & [PERSON] et al. [22] & \\  & [PERSON] et al. [24] & \\  & [PERSON] et al. [25] & \\ \hline \multirow{6}{*}{Myocardialitis} & [PERSON] et al. [33] & \\  & [PERSON] et al. [31] & \\  & [PERSON] et al. [34] & \\  & [PERSON] et al. [35] & \\  & [PERSON] & \\  & et al. [36] & \\  & [PERSON] et al. [37] & \\  & [PERSON] et al. [38] & \\ \hline \multirow{2}{*}{Hyperthropic cardiomyopathy} & \multirow{2}{*}{[PERSON] et al. [48]} & \multirow{2}{*}{\begin{tabular}{c} Basal interventricular septum, \\ particularly at the anterior and posterior \\ right ventricular insertion points. \\ \end{tabular} } \\  & & & Variable, usually observed in the \\  & [PERSON] et al. [48] & \\  & [PERSON] et al. [49] & \\  & & & \\  & & & \\  & & & \\ \hline \multirow{2}{*}{Amyloidosis} & [PERSON] et al. [55] & \multirow{2}{*}{\
\begin{tabular}{c} Global subendocardial or diffuse \\  & & & \\  & & & \\  & & & \\ \hline \multirow{2}{*}{Mitral valve prolapse} & \multirow{2}{*}{
\begin{tabular}{c} [PERSON] et al. [44] \\ disjunction \\ \end{tabular} } \\  & & & & \\ \end{tabular}
\end{table}
Table 1: The most typical distribution patterns of delayed enhancement in both ischemic and non-ischemic heart diseases and some of the key authors investigating the role of LIE-CT in these pathologies.  
the difficulty in detecting diffuse myocardial LIE due to poor contrast between the enhanced and normal myocardium, and the unavailability of dual-energy technology, which has shown the best results in the literature. The major advantages and disadvantages of LIE-CT are summarized in Table 2.