## 2 Materials and Methods
### Individual Cases Description  
Case 1 describes a 24-year-old Caucasian referral male patient presenting with DA at sites #35 and #45, orthodontically treated for space maintenance. Tooth #75 was previously lost by spontaneous exfoliation (Figure 1). Tooth #85 was affected by severe rhizolysis, resulting in a poor prognosis for conservative treatment. The edentulous site was characterised by moderate atrophy in the horizontal and vertical directions with sufficient bone volume for implant placement. Tooth #85 was extracted under local anesthesia (LA), followed by the immediate placement of a BLT RC implant (4.1 \(\times\) 10 mm) (Figures 2 and 3). Lateral and mesiodistal gaps around the implant were augmented. Figure 1: Panoramic radiograph and clinical situation of sites #45 (**left** images) and #35 (**right** images) of Case 1 prior treatment. Figure 2: Extraction of #85 and osteotomy preparation at site #45.  
comparably stable bone levels for the two sites. An incomplete papilla was noted at the distal aspect of crown 35 (Figure 7). The patient expressed his satisfaction with the result on both sides without expressing an aesthetic preference. He also expressed superior postoperative comfort on the right side receiving immediate placement compared to the side treated with a delayed protocol. Case 2 describes the implant therapy of a 35-year-old African female patient at DA sites #35 and #45. An intraoral examination revealed site #45 to be dedentulous following spontaneous exfoliation of tooth #85 several months prior to treatment. Tooth #75 displayed degree-three mobility in the context of periodontal disease, resulting in a poor prognosis for preservation. (Figure 8). Figure 6: Illustration of the prosthetic delivery 2 months post-op for sites 45 (**upper** image row) and 35 (**lower** image row), comprising clinical situations at the 2 months post-op reentry, after removal of healing abutments and placement of final crowns prior to closure of abutment holes. Figure 7: Lateral view comparing the soft tissue situations at the 1-year follow-up of sites 45 (**left** image) and 35 (**right** image). Tooth 75 was extracted under AL, followed by the immediate placement of a BLT RC 4.1 \(\times\) 10 mm implant at site #35. Delayed implant placement of the same implant type, in analogy to the above-presented procedures, was performed at site 45. At seven days post-op, the wound healing was adequate. The patient reported to have experienced pain on the right side for the first 3 days, relieved by paracetamol 1 g, and no symptoms on the left side. Clinically, there was no evidence of infection or swelling on either side. The screw-retained crowns were delivered two months post-surgery (Figure 9), and the clinical and radiological situations were stable at the 1-year follow-up appointment (Figure 10). Figure 8: Panoramic radiograph of case 2 prior to treatment with DA sites 45 (edentulous) and 35 (with deciduous tooth in situ). Figure 10: Periapical radiographs at 2 months post-op (**upper** images) and at the 1-year post-op follow-up (**lower** images) of sites #35 (**left** images) and #45 (**right** images). Case 3 describes a 44-year-old female Caucasian patient with controlled type I diabetes presenting at the University Hospital with a chief complaint of pain at tooth #85. Radiographic and intraoral examination revealed DA at sites #35 and #45, with tooth #75 missing. Tooth #85 presented pulp necrosis due to perforating caries (Figure 11). As the prognosis of tooth #85 was poor, the tooth was extracted under local anaesthesia, followed by the immediate placement of a BLT RC 4.1 \(\times\) 10 mm implant (Figures 12 and 13). Site #35 received the same implant type following the delayed procedure described above. Screw-retained crowns were delivered 2 months post-surgery (Figure 14). 1- and 2-year follow-up examinations revealed stable clinical and radiological situations.