Vibration-induced failure and lifetime assessment are also important in structure analysis. Several relevant studies are reviewed below. [PERSON], et al. [11], analyzed the lifetimes of fired heater tubes. The authors statistically characterized the uncertainty associated with the omega creep procedure of the API-579 Part 10 by treating the primary input parameters as random variables and processes. They also employed Monte Carlo simulations to estimate the probability of tubes failing for a specified time. [PERSON], et al. [12], analyzed reformer catalyst tubes which had failed after eight years of service. They assessed the tube lifetime by the Larson-Miller parameter method. The authorsconcluded that the failure was caused by local overheat, leading to premature creep failure. [PERSON], et al. [13], investigated the remaining life of the catalyst tubes of a fertilizer plant. The investigation included microscopy, hardness measurement, dimensional measurement, hot tensile tests, and accelerated creep tests. The authors concluded that overheating was the primary cause of the significant degradation in the microstructures and mechanical properties of the catalyst tubes. [PERSON] [14] reported a stochastic approach under variability of different input parameters to investigate the fatigue crack growth in a railway axle. They used the approach to predict the probability distribution of the residual fatigue life for a railway axle in the presence of defects when considering multiple sources of uncertainty. [PERSON] and [PERSON] [15] discussed the vibration and fatigue failures at pipeline facilities. They reviewed the vibration phenomena occurring at pipeline facilities and took practical examples to illustrate the types and ways of resolving vibration-induced fatigue failures at pipeline facilities. [PERSON] [16] investigated the damages caused by acoustic-induced vibrations and flow-induced vibrations in pipelines, plants, and facilities. He gave practical examples to illustrate the types and ways of resolving the two vibration-induced failures. [PERSON], et al. [17], theoretically and experimentally discussed the piping vibration phenomena and the ways of preventing vibration-related damage. They also investigated an empirical rule by experimental measurement and numerical analysis. More literature related to vibration-induced failure and lifetime assessment can be found in the author's previous studies [18; 19; 20]. From the above literature, many experimental and numerical investigations in structure analysis have been conducted. However, very few structural analyses of petrochemical heaters were presented in public literatures. Nevertheless, the structural design of a heater is undoubtedly closely connected with its performance and operating security, which in turn strongly affects the profits, capacities, and product qualities of the petrochemical industry. Therefore, this study aims to investigate the operating security of a petrochemical heater under the action of a strong wind. When the fatigue limit was exceeded, the support frame was damaged. The support frames were made of steel and were used to bear the heater under the action of wind and gravity. In this study, we first performed an in situ measurement for the stress distribution of a petrochemical heater. Next, we applied the finite element method to analyze its vibration modes and stress distribution. The aims of this study were to ensure that (1) the potential threat of fatigue failure could be detected in an earlier phase, (2) the stress monitoring in situ, service life assessment, and subsequent improvement tasks could proceed smoothly, and (3) the operating security of the heater could be ensured.