## 1 Introduction  
New natural product development must meet the requirements of Current Good Manufacturing (cGMP) as well as satisfy consumer demands for a tasty, nutritious, and healthful result. Extraction is a critical stage in the food, nutraceuticaltical, and pharmaceutical industries [1]. Bioactive components from a plant can be obtained by extracting various parts such as leaves, flowers, fruits, stems, or tubers. The primary goal of extraction is to employ a cost-effective, eco-friendly technique that produces a high and consistent yield of bioactive components in a short period. Therefore, significant efforts are required to maximize and stabilize extract production [2]. Maceration and Soxhlet extraction are commonly used laboratory-scale methods, while percolation is widely used on an industrial scale. Percolation provides a continuous flow of the menstruum through the material in a percolation cone [3]. Many plant extraction facilities prefer percolations because they are more efficient, requiring a smaller ratio of simplicia to solvent, shorter extraction time, better extract quality and stability, and higher yield [4; 5; 6]. Traditionally, percolation completes the extraction process in hours, compared to maceration, which can take 2-4 weeks, with an average extraction efficiency of 63.52% [5]. The efficiency of percolation extraction is influenced by factors such as solvent, wetting time, solvent flow rate, loading capacity, particle size, and temperature [7]. Polar solvents are frequently used for recovering polyphenols from plant matrices. Ethanol is a preferred solvent due to its efficiency in polyphenol extraction and is safe for human consumption. Chemical components soluble in water and/or organic solvents can dissolve more easily when ethanol and water are combined properly. The 60% ethanol solvent can remarkably dilute phytochemical compounds since the solvent contains optimum water content that could help in the extraction process. In this way, most of the compounds would be attracted to the ethanol and some in the water. For extracting flavonoids from tea, aqueous ethanol performed better than aqueous methanol and aqueous acetone [8]. Extracts with the greatest antioxidant activity were obtained in mate tea and black tea by using 50% aqueous ethanol and 50% aqueous acetone, respectively [9]. Epicatechin, a potent antioxidant flavonoid, is maximally produced using 70% ethanol [10]. In addition, a wetting time of 1 h before percolation increases the yield [11]. Changes in the type and amount of chemical components may occur due to the complexity of the process from raw material to finished products. Therefore, a system is needed to guarantee the quality, safety, and efficacy of the resulting product. The European Product Evaluation Agency (EMEA) and the Food and Drug Administration (FDA) endorsed chromatographic fingerprinting for quality control of raw materials, preparations, and final products [12; 13]. If the chromatographic fingerprint of an herbal is identical to its botanical reference material or standardized extract, it is considered that the herb is phytoequivalent to the standard [14]. TLC is widely used for process monitoring and quality documentation, ensuring batch-to-batch consistency [15]. The TLC fingerprint of _Ipomoea hatatas_ L. has been successfully identified [16; 17], with 11 peaks identified as flavonoid and anthocyanin compounds at UV wavelengths of 330 nm and 543 nm [17]. Fingerprint reproducibility, consistency, and stability can be evaluated using similarity values [18]. The assessment of fingerprint similarities, differences, and consistency can be assessed objectively using a multivariate analysis approach [19; 20]. The sweet potato (_Ipomoea hatatas_ L.) ranks as the world's sixth most popular food crop due to its high productivity and adaptability to various climates [21]. Though the leaves are mainly utilized for animal feed, research is mainly focused on the tubers.