## 3 Results and Discussion
### The Effect of Fruit Enzymes at Differential Concentration on the Change of Various Floaters
\begin{table}
\begin{tabular}{c c c c c} \hline \hline
**Numbers of Capsules Each Day** & **Before** & **1 st Month** & **2 nd Month** & **3 rd Month** \\ \hline none & 40 & 40 & 40 & 38 (95.0\%) \\
1 capsule & 40 & 38 & 33 & 14 * (35.0\%) * \\
2 capsules & 40 & 35 & 32 & 12 * (30.0\%) * \\
3 capsules & 40 & 34 & 30 & 10 * (25.0\%) \\ \hline \hline \end{tabular}  
1. Group 1 (n = 40 eyes): no proteases were taken (placebo group). Group 2: (n = 40 eyes): all volunteers took 1 capsule with mixed proteases including 190 mg bromelain, 95 papain and 95 ficin every day: Group 3 (n = 40 eyes): All patients took 2 capsules daily. Group 4 (n = 40 eyes): all patients took 3 capsules daily. 2. At first, we compared the results at the beginning and during the whole 3 months by Scheffe test in the four groups. Statistical significance was considered at \(p<0.05\) (We make * as a symbol). 3. Moreover, we further compared the outcome at the 3 rd month (Group 2, Group 3 and Group 4) with the placebo group by Williams test. A \(p\)-value of less than 0.05 was considered to indicate a statistically significant difference (We mark # as a symbol).  
\end{table} 
Table 2: Change in ocular floaters before and after the fruit enzymes at differential concentration over a 3-month treatment. adaptation. In most cases, the initial symptoms are transient as the patients learn to 'live with them'. However, some patient cases continue to have quite troublesome floaters even with good visual acuity. The vitreous is composed of collagen fibers (-0.5%), HA (-0.5%) and water (-99%) and is characterized by the dilute dispersion of collagen fibrils interspersed with extensive arrays of HA. Taken together, HA is the predominant macromolecule that could form a meshwork and an unbranched polymer of disaccharides linked by the glycosidic bonds. Many enzyme fruits could degrade HA by cutting the glycosidic bonds and breaking down vitreous opacity. Moreover, collagens are organized into fibrils with Types I, II, III, IV, V, VI, IX and XI, which provides a solid structure. It is also known the vitreous consists of collagens, glycosaminoglycans, PGs and hydrated ECM molecules (e.g., fibrillin and opticin). With aging, there is a loss of Type IX collagen from the fibril surfaces. Moreover, loss of the Type IX collagen chondroitin sulfate chains from the fibril surfaces combined with increased surface exposure of Type II collagen results in fibrillar aggregation. Finally, the purpose of any method of vitreous for treating SVOs is to clear vitreous strands and opacities. Current treatments for ocular floaters and SVOs include observation, Nd:YAG laser vitreolysis, PPV and newly developing pharmacologic vitreolysis. At first, close and regular observation by experienced ophthalmologists was indicated when the victims experiencing limited vision were relatively young or extremely old. Patients with few floaters and SVOs should receive close follow-up. The treatment success rate varies and cannot be predicted. However, most patients desire more aggressive treatments for resolution of visual symptoms and psychological problems. Nd:YAG laser, which vaporizes opacities, is attractive due to its effectiveness and ease in treating the middle or posterior floaters. The laser would be used for the lysis of fibers, rheis of aggregates and displacement out of the visual axis. Now, it has been too widely used for severe vitreous strands and breaking larger opacities into small particles. For therapy, we always use the sufficient energy (3 to 4 mJ) to treat opacity, as well as a sufficient number of laser pulses (150 to 200 pulses) to treat SVOs. Typically, only opacities relatively far from the retina are treated; thus, the therapy may be appropriate for only some patients. Unfortunately, the laser has the potential risks of cataracts, elevated IOP, posterior capsule defects, retinal tear or hemorrhage and RD [24]. However, the amorphous floaters in the mid- to posterior vitreous are difficult to visualize and treat by laser sometimes.