## 3 Results and Discussion
### Molecular Docking Studies
\begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Compounds** & **NADPH Osidase** & **Cyclochrome F490 (CP480)** & **Lipoxygenase** & **Myeloperoxidase** & **Xanthine Oxidase (NO)** \\
**(PDB: 2 CDU)** & **(PDB: 10 GS)** & **(PDB: 10 GS)** & **(PDB: 1 NQQ)** & **(PDB: 1 DNN)** & **(PDB: 3 NKE)** \\ \hline \multicolumn{5}{c}{**Interactions**} \\ \hline \multirow{2}{*}{Hesperetin} & HR: **Val214** & HR: **Scx265** & \multirow{2}{*}{NO} & HR: **Arg188**, **Val199**, **Gla201** & **HR: **Thr1010** \\  & p1-p1: **Hiss1** & p1-p1: **Phel76** & & & \\ \hline \multirow{2}{*}{Hesperetin} & HR: **Ide243**, **Av246** & HR: **Ide248** & \multirow{2}{*}{NO} & HR: **Arg188**, **[PERSON]**, **[PERSON]**, **Gla201** & **p1-p1** **Phel100** \\  & & p1-p1: **Phel14** & & & \\ \hline \multirow{2}{*}{Kemperel 3-glucose} & HR: **[PERSON]**, **[PERSON]** & HR: **[PERSON]** & \multirow{2}{*}{NO} & HR: **[PERSON]**, **[PERSON]**, **[PERSON]**, **[PERSON]**, **[PERSON]** & **NO** \\  & & p1-p1: **Hiss1** & p1-p1: **Phel14** & & & \\ \hline \multirow{2}{*}{Mytreton} & HR: **[PERSON]** & HR: **[PERSON]** & \multirow{2}{*}{NO} & HR: **[PERSON]**, **[PERSON]**, **[PERSON]**, **[PERSON]** & **HR: **[PERSON]**, **[PERSON]** \\  & & p1-p1: **Phel76** & & & & \\ \hline \multirow{2}{*}{[PERSON]} & HR: **Ide381**, **V214** & HR: **[PERSON]** & \multirow{2}{*}{NO} & HR: **Asn186**, **Asn189**, **Phel213** & **HR: **Ide248** \\  & & p1-p1: **Phel76** & & & & \\ \hline \multirow{2}{*}{[PERSON]} & HR: **Ide381**, **V213**, **Av246** & HR: **Phel00**, **Th201** & \multirow{2}{*}{NO} & HR: **Asn186**, **Arg188**, **Net190**, **Phel214** & **NO** \\  & & p1-p1: **Phel14** & & & & \\ \hline \multirow{2}{*}{Procyandin B1} & HR: **[PERSON]**, **V214** & HR: **[PERSON]**, **Le240** & \multirow{2}{*}{NO} & HR: **Gln201**, **Gla201**, **Gla204**, **Gla207** & **NO** \\  & & p1-p1: **Phel24** & & & & \\ \hline \multirow{2}{*}{Procyandin B2} & HR: **[PERSON]**, **Lys187** & HR: **[PERSON]** & \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & HR: **[PERSON]**, **[PERSON]**, **Gla207**, **Av259** & **NO** \\  & & p1-p1: **Phel76** & & & & \\ \hline \multirow{2}{*}{Pyregalloid} & HR: **Asp197**, **Lys187** & HR: **Ide386** & \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & HR: **Asn196**, **Gla2021**, **Gla202** & **HR: **Asn196**, **Tru1010** \\  & & p1-p1: **Phel76** & & & & \\ \hline \multirow{2}{*}{Quertition 3-glucose} & HR: **Asp197**, **Gly180**, **Lys213**, & HR: **Ala100**, **Le203**, **Asn217**, & \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & HR: **Asn186**, **Av189**, **Asn189**, **Net190**, **Ser191**, **Val199** & **NO** \\  & & p1-p1: **Phel14** & & & & \\ \hline \multirow{2}{*}{Reversearch} & HR: **Ide381**, **Lys187**, **Lys188**, **Lys187**, **Lys188** & HR: **Sx456** & \multirow{2}{*}{\begin{tabular}{} \end{tabular} } & HR: **Asn200**, **Gla201**, **Gla203** & **p1-p1** **Phel14**, **Phel1009** \\  & & p1-p1: **Phel76** & & & & \\ \hline \multirow{2}{*}{Retin} & HR: **Ide3823**, **Val214** & HR: **Asn107**, **Leu203**, **Gla214** & \multirow{2}{*}{NO} & HR: **Asn189**, **Gla201**, **Gla201**, **Gla202** & **NO** \\  & & p1-p1: **Phel76** & & & & \\ \hline \multirow{2}{*}{Syrnigic acid} & HR: **Ide382** & \multirow{2}{*}{\
\begin{tabular}{} \end{tabular} } & HR: **Asn106**, **Leu203**, **Gla214** & \multirow{2}{*}{NO} & HR: **Asn189**, **Gla201**, **Aan258**, **Asn540** & **NO** \\  & & p1-p1: **Phel73** & & & & \\ \hline \multirow{2}{*}{Syrnigic acid} & HR: **Val214** & HR: **Ide386**, **Ser365** & HR: **Ide387** & HR: **Arg188**, **Met190**, **Ser191**, **Val199** & **HB: **Asn706**, **Clus202** \\  & & & p1-p1: **Phel76** & & & \\ \hline \multirow{2}{*}{Vanillic acid} & HR: **Asp197**, **Val214** & HR: **Ide386** & \multirow{2}{*}{
\begin{tabular}{} \end{tabular} } & HR: **Asn196**, **Met190**, **Val199** & **HB: **Gla202**, **Arg88**, **Tru1010** \\  & & p1-p1: **Phel76** & & & & \\ \hline \multirow{2}{*}{\({}^{1}\)HB: Hydrogen bond; NO: not observed. \({}^{2}\) Notes in bold refer to the crucial amino acids for the binding} & & & & \\ \end{tabular}
\end{table}