## 2 Materials and Methods
### Synthesis
General procedure for the preparation of hydrazones **7**, **8**  
A solution of hydrazide **4** (0.5 g, 1.6 mmol) and the corresponding aldehyde (1.8 mmol) in propan-2-ol (10 mL) was refluxed for 7-11 h. After completion of the reaction, the mixture was cooled, the formed precipitate was filtered off, washed with propan-2-ol and diethyl ether, and dried. The obtained compounds were purified by recrystallization from propan-2-ol. \(N^{\prime}\)-((5-nitrofuran-2-yl)methylene)-5-oxo-1-(3,4,5-trimethoxyphenyl)pyrrolidine-3-carbohydrazide (7)  
Light yellow solid, yield 0.7g (86%), m. p. 213-215 \({}^{\circ}\)C.  
\({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\): 2.66-2.88 (m, 2H, CH\({}_{2}\)CO), 3.63, 3.76 (2s, 9H, 3 OCH\({}_{3}\)), 3.94-4.15 (m, 3H, NCH\({}_{2}\), CH), 6.98 (s, 2H, H\({}_{Ar}\)), 7.21-7.32 (m, 1H, H\({}_{Het}\)), 7.74-82 (m, 1H, H\({}_{Het}\)), 7.98 (s, 0.6H, CH=N), 8.19 (s, 0.40H, CH=N), 11.98 (s, 0.60H, CONH), 12.02 (s, 0.4H, CONH) ppm. \({}^{13}\)C NMR (101 MHz, DMSO-\(d_{6}\)) \(\delta\): 32.57, 34.88, 35.11, 35.66, 50.31, 50.77, 55.90, 60.11, 97.88, 98.10, 114.59, 114.75, 115.51, 131.87, 134.27, 134.32, 135.01, 135.17, 135.20, 151.56.151, 151.61, 151.77, 151.96, 152.68, 169.26, 171.59, 171.76, 174.09 ppm. IR (KBr): \(\gamma_{\rm{max}}\): 3190, (NH), 1687, 1668 (2C=O), 1251, 1204 (3 OCH\({}_{3}\)) cm\({}^{-1}\). Anal. Calcd. for C\({}_{19}\)H\({}_{20}\)N\({}_{4}\)O\({}_{8}\), %: C 52.78; H 4.66; N 12.96. Found: C 52.68; H 4.57; N 12.89. \(N^{\prime}\)-((5-nitrothiophene-2-yl)methylene)-5-oxo-1-(3,4,5-trimethoxyphenyl)pyrrolidine-3-carbohydrazide (8)  
Yellow solid, yield 0.46 g (64%), m. p. 219-221 \({}^{\circ}\)C.  
\({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\): 2.69-2.88 (m, 2H, CH\({}_{2}\)CO), 3.63, 3.76 (2s, 9H, 3 OCH\({}_{3}\)), 3.92-4.19 (m, 3H, NCH\({}_{2}\), CH), 6.99 (s, 2H, H\({}_{Ar}\)), 7.50-7.61 (m, 1H, H\({}_{Het}\)), 8.06-8.14 (m, 1H, H\({}_{Het}\)), 8.20 (s, 0.65H, CH=N), 8.48 (s, 0.35H, CH=N), 12.00 (s, 1H, CONH) ppm. \({}^{13}\)C NMR (101 MHz, DMSO-\(d_{6}\)) \(\delta\): 32.82, 34.82, 35.12, 35.59, 50.29, 50.81, 55.90, 60.11, 97.88, 98.05, 129.27, 129.81, 130.64, 134.29, 135.16, 135.22, 136.93, 140.63, 146.47, 146.57, 150.56. 152.67, 169.18, 171.62, 171.71, 173.82 ppm. IR (KBr): \(\gamma_{\rm{max}}\): 3115, (NH), 1692, 1665 (2C=O), 1266, 1219 (3 OCH\({}_{3}\)) cm\({}^{-1}\). Anal. Calcd. for C\({}_{19}\)H\({}_{20}\)N\({}_{4}\)O\({}_{7}\)S, %: C 50.89; H 4.50; N 12.49. Found: C 51.80; H 4.43; N 12.39. General procedure for the preparation of hydrazones **9**-**18**  
A mixture of carbohydrate **4** (0.5 g, 1.6 mmol), the corresponding aldehyde (1.7 mmol), and propan-2-ol (10 mL) was refluxed for 3-8 h. Afterwards, the reaction mixture was cooled, the obtained product was filtered off, washed with propan-2-ol and diethyl ether, and recrystallized from the indicated solvent. \(N^{\prime}\)-benzylidene-5-oxo-1-(3,4,5-trimethoxyphenyl)pyrrolidine-3-carbohydrazide (9)  
White solid, yield 0.46 g (72%), m. p. 142-144 \({}^{\circ}\)C (from propan-2-ol). \({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\): 2.68-2.88 (m, 2H, CH\({}_{2}\)CO), 3.63, 3.76 (3s, 9H, 3 OCH\({}_{3}\)), 3.92-4.18 (m, 3H, NCH\({}_{2}\), CH), 6.99 (s, 2H, H\({}_{Ar}\)), 7.34-7.76 (m, 5H, H\({}_{Ar}\)), 8.04 (s, 0.65H, CH=N), 8.24 (s, 0.35H, CH=N), 11.59 (s, 0.65H, CONH), 11.65 (s, 0.35H, CONH) ppm. \({}^{13}\)C NMR (101 MHz, DMSO-\(d_{6}\)) \(\delta\): 32.72, 34.76, 35.21, 35.74, 50.45, 51.00, 55.91, 60.11, 97.85, 98.07, 126.90, 127.10, 128.85, 129.93, 130.14, 134.13, 134.23, 134.28, 135.22, 135.28, 143.69, 147.08, 152.67, 168.64, 171.78, 171.92, 173.60 ppm. IR (KBr): \(\
u_{\rm max}\): 3133, (NH), 1680, 1655 (2C=O), 1296, 1280, 1233 (3 OCH\({}_{3}\)) cm\({}^{-1}\). Anal. Calcd. for C\({}_{21}\)H\({}_{23}\)N\({}_{3}\)O\({}_{5}\), %: C 63.47; H 5.83; N 10.57. Found: C 63.39; H 5.75; N 10.48. \(N^{\prime}\)-(4-chlorobenzylidene)-5-oxo-1(3,4,5-trimethoxyphenyl)pyrrolidine-3-carbohydrazide (**10**) White solid, yield 0.59 g (85%), m. p. 184-186 \({}^{\circ}\)C (from propan-2-ol).