which is a time-consuming and labor-intensive procedure that does not provide in situ information on the distribution of pesticide residues in the tea samples [12]. [PERSON] et al. developed a new electrochemical molecularly-imprinted polymer aptasensor, demonstrating exceedingly high sensitivity and enhanced selectivity in CBZ detection. However, special and complex preprocessing steps were required, possibly affecting the accuracy of quantitative results [17]. In addition to traditional chemical analysis methods, laser ionization mass spectrometry analysis methods have been developed in recent years, and these have benefitted from novel ion source technologies. Secondary ion mass spectrometry (SIMS), thermal desorption ionization (DART), matrix-assisted laser desorption ionization (MALDI), and laser desorption postionization (LDPI) have been developed, and they require almost no sample preparation [18; 19; 20]. The applicability of ionization mass spectrometry analysis methods has been demonstrated for a variety of analytes, e.g., biological and environmental samples including alkaloids in plants, phospholipids in mammalian tissues, and lipids and proteins in bacteria [21; 22]. Substantial progress was made in the last decade in MALDI-MS analyses for complex protein samples, especially biomolecules, because innovative \"soft ionization\" MS techniques offered advantages in sample-integrity preservation, strong molecular ion peaks, and high sensitivity [23; 24]. However, interference peaks can be generated from matrices used in the MALDI-MS detection methods in the low-molecular-weight region, which may adversely affect the detection of target compounds. Consequently, MALDI is satisfactorily employed for high-molecular-weight molecules, such as proteins, carbohydrates, and proenzymes, while the results for substances with a relative molecular weight lower than five hundred, such as amino acids, are often unsatisfactory [25; 26; 27; 28]. LDPI-MS has a working principle similar to that of MALDI-MS, and yet, there are some important differences [29]. LDPI-MS utilizes two experimental lasers with different energies to complete the sample desorption and ionization processes separately. The method was previously used to detect the distribution of polycyclic aromatic hydrocarbons in gasoline aerosols and analyze drugs and biomaterials [30; 31]. The ionization process in LDPI-MS mainly involves two independent steps: desorption gasification and ionization after desorption. In the first step, a sample is irradiated with a desorption laser; typically, a low-energy infrared laser is applied. The laser effectively vaporizes stable and non-volatile substances within a few microseconds, facilitating the gasification process [32]. Generally, gaseous particles formed upon the sample's vaporization aggregate into small, electroneutral gaseous clusters which float at a vertical distance of approximately 1 mm from the sample platform. After the vaporization process is completed, a second laser beam is applied after a certain delay time. In general, the ionization laser used in LDPI-MS is a vacuum ultraviolet (VUV) laser, with its photon energy reaching 10.48 eV. This energy level is higher than the ionization energy of most molecules. Therefore, gasification and ionization of target molecules can be achieved using single-photon energy, which also helps minimize the generation of abundant ion fragments [33]. LDPI-MS has several unique advantages over other types of ionization sources. First, fewer fragment peaks form due to the soft VUV-laser single-photon ionization, resulting in a greater proportion of intact molecular peaks and improved experimental accuracy [34]. Second, the separate utilization of two laser beams provides a basis for optimizing the experimental operation and makes it more convenient [35].