## 4 Discussion
### Literature Review Results  
The literature review considered both case reports and case series, to address the lack of clinical trials conducted on the topic.  
Ten case reports [11; 12; 13; 14; 15; 16; 17; 18; 19; 20] and thirteen case series [21; 22; 23; 24; 25; 26; 27; 28; 29; 30; 31; 32; 33] were analyzed, noting the surgical method, the outcome, and the presence of lesion recurrence in the clinical follow-up. Of the studies, 82.61% took into consideration patients under the age of 30, confirming both the prevalence of the lesion in the younger population and the prevalence of the lesion in females. As far as the location of the lesions is concerned, 34.78% of the articles examined reported the oral floor as the location of the finding, 52.17% reported lesions located on the lower lip, 47.83% reported the lingual mucosa as the location, and, finally, there were cases of lesions located in the buccal mucosa, soft palate, and upper labial mucosa, in line with the literature reviews already present on the databases concerning epidemiological data.  
The articles included in the review reported different treatment strategies, both regarding surgical and non-surgical procedures. The surgical procedures used were excision by traditional surgery with a scalpel blade [14; 17; 18], excision by laser-assisted procedures [12; 13; 20; 30], micro-marsupialization [21; 23; 24; 29], and microwave ablation [22]. The non-surgical procedures were cryotherapy [11; 16; 26], the intralesional application of drugs and medications such as corticosteroids, absolute ethanol, and OK-432 solution [27; 28; 32; 23], sclerotherapy [15; 25], acupuncture [19], and the topical application of primrose oil [31]. All the treatments analyzed were aimed at the removal of the lesion; the surgical treatments resulted in the removal of 100% of the lesion [13; 14; 17; 18; 20; 21; 23; 24; 29; 30]; on the other hand, with regard to the non-surgical treatments, including sclerotherapy with promethazine hydrochloride [15], nitrous oxide cryotherapy [25], dexamethasone [27], and intralesional injection of OK-432 [28], showed a partial resolution of the lesion, or resolution after subsequent sessions. Treatments conducted via acupuncture [19] and the topical application of primrose oil [31] were equally effective in reducing and removing lesions but were proven to be the most time-consuming and challenging, requiring more treatment sessions and extended periods of therapy [19; 31]. The outcome also differed for the use or not of sutures: in the surgical methods with traditional cold blade surgery, in all cases it was necessary to suture the wound [14; 17; 18], while in the cases treated with laser-assisted procedures, the cauterization of the surgical site took place simultaneously with the excision, requiring no further medication [12; 13; 20; 30]. The same result was obtained with cryotherapy which did not require subsequent suturing [11; 16; 26]. The non-surgical procedures did not require any follow-up medications, other than pain relievers as needed. In terms of recurrence of the lesion, the follow-ups of the cases were very varied; the minimum follow-up was three months up to a maximum of four years. In this period, a recurrence in lesions was noted in patients treated with microwave ablation [22], micro-marsupialization [21; 23; 24; 29], sclerotherapy with promethazine hydrochloride, and intralesional injection of corticosteroids [27; 28; 32; 33].