# Additive and Dominance Genomic Analysis for Litter Size in Purebred and Crossbred Iberian Pigs
## 4 Conclusions  
(1) The additive genetic variance and the heritabilities were higher in the crossbred than those in the purebred populations, (2) the genetic correlation between purebred and crossbred performances were higher in Retinto than they were in Entrepelado pigs, and (3) the additive genetic variances were heterogeneously distributed throughout the autosomal genome, and four genomic regions in SSC6, SSC8, and SSC12 with several candidate genes were identified. **Supplementary Materials:** The following supporting information can be downloaded at: [[https://www.mdpi.com/article/10.3390/genes13010012/s1](https://www.mdpi.com/article/10.3390/genes13010012/s1)]([https://www.mdpi.com/article/10.3390/genes13010012/s1](https://www.mdpi.com/article/10.3390/genes13010012/s1)). Table S1: REML estimates \(\pm\) the standard error (SE) of the additive genotypic (co)variances for the number born alive (NBA). Table S2: REML estimates \(\pm\) the standard error (SE) of the dominance genotypic (co)variances for the number born alive (NBA). Table S3: REML estimates \(\pm\) the standard error (SE) of the permanent environmental and residual variances for the number born alive (NBA). Table S4: GO (Gene Ontology) terms for the biological process of the proposed candidate genes. Figure S1: Distribution of the percentage of the additive genetic variance explained by genomic segments of 30 SNPs within the autosomal genome of the purebred and crossbred performance for the number born alive (NBA) in the Entrepelado and Retinto varieties. Figure S2: Distribution of the percentage of the additive genetic variance explained by genomic segments of 20 SNPs within the autosomal genome of purebred and crossbred performance for the total number born (TNB) in the Entrepelado and Retinto varieties. Figure S3: Distribution of the percentage of the additive genetic variance explained by genomic segments of 40 SNPs within the autosomal genome of the purebred and crossbred performance for the total number born (TNB) in the Entrepelado and Retinto varieties. **Author Contributions:** Conceptualization, L.V. ; methodology, H.S. and L.V. ; software, L.V. ; formal analysis, H.S., V.T. and L.V. ; data curation, J.L.N., J.P.R., M.M.d.H. and N.I-E.; writing--original draft preparation, H.S. and L.V. ; writing--review and editing M.M.d.H., M.V.-G., N.I.-E., M.M.-C. and J.C.;  
\begin{table} \begin{tabular}{l c c c} \hline \hline
**SNP1** & **SSC2** & **bp 3** & **Genes** \\ \hline rs326244568 & 6 & 7,597,405 & _BCO1_, _PKD112_, _GCSH_, _ATMIN_, _CENPN_, _CDYLZ_, _DYNLRB2_ \\ rs81401202 & 8 & 11,585,865 & _CD38_, _FGFBPI_, _PROMI_, _TAPTI_, _LDB2_ \\ rs81406142 & 8 & 137,540,516 & _CFAP299_, _FG5_, _PROMMS_, _ANTXR2_ \\ rs345468811 & 12 & 46,079,417 & _TAOK1_, _ABHD15_, _TP53113_, _GIT1_, _ANKRD1_, _COR06_, _EFCAB5_, _NSRP1_, _SLC6A4_, _BLMH_, _TMIGCD1_, _COD_, _GOSR1_ \\ \hline \hline \end{tabular}  1
[FOOTNOTE:1]Footnote 1: SNP: single nucleotide polymorphism, 2
[FOOTNOTE:2]Footnote 2: SNP: single nucleotide polymorphism, 2
supervision, L.V., N.I.-E., J.C. and J.L.N., project administration, J.L.N., J.C. and N.I.-E.; funding acquisition, J.L.N., J.C. and N.I.-E. All authors have read and agreed to the published version of the manuscript. The research was partially funded by grants CGL2016-80155-R and PID2020-114705 RB-I00 (Ministerio de Ciencia e Innovacion), and IDI-20170304 (CDTI). Srihi received funding from the European Union's H2020 research and innovation program under a Marie Sklodowska-Curie grant agreement, No. 801586. The protocols were approved by the Ethical and Animal Care Committee at IRTA (Institute of Agrifood Research and Technology, Caldes de Montbui, Spain; IRTA-22032012). It was performed according to the Spanish Policy for Animal Protection (RD 53/2013), which meets the European Union Directive 2010/63/UE on the protection of research animals. Not applicable. The dataset used in this study will be available upon reasonable request to the corresponding author ([PERSON]ADDRESS]).