## 1 Introduction  
Morocco has a vegetal flora that is rich and diversified. Among the medicinal plants that constitute vegetal cover, the genus _Artemisia_ is a greenish-silver perennial, biennial, annual herb dwarf and evergreen shrub, growing widely in arid and semiarid climates as well as in cold and subhumid regions, warm climates, and muddy areas [1; 2; 3]. _Artemisia herba-alba_ Asso, called by the common name wormwood, is widespread throughout the northern half of the world, found in the steppes and deserts of North Africa (Morocco, Algeria, Tunisia, Libya, and Egypt) [4; 5], the Middle East (Turkey, desert of Sinai, Jordan, and Saudi Arabia), Asia and the Northwestern Himalayas, and extending into Europe (Spain) and North America [6; 7; 8]. This perennial herb is abundant in Morocco, where it inhabits clay steppes, meadows, rocky earth plateaus, and low mountains in dry and piedmont regions. It grows in stony lands and pastures, and spans a wide geographical distribution in Morocco (Est, Est-Rif, Middle-Atlas, High-Atlas, Saharan-Atlas) under a hot Saharan biocimate [1; 6; 8]. _Artemisia herba-alba_ Asso is commonly known as \"chih\" in Arabic or \"Ifsi\" in Berber. It is known for its therapeutic and medicinal properties and has been widely used in traditional Arab-Muslim culture as a source of green nanoinsecticides against mosquito vectors [9], and in modern medicine [10] to treat bronchitis, hypertension, neuralgia, and stomach disorders. It can be consumed as a carminative and presents a wormer effect during diseases [11]. In addition, different types of _Artemisia_ species represent a source of economic support for local (traditional activities) or nonlocal (recent activities) populations in several fields: cosmetics, food, medicine, and folk medicine, ethnopharmacology (as an analgesic and hemostatic agent), and pharmaceuticals [7; 10]. Referring to previous studies concerning the medicinal properties of _Artemisia herba-alba_ essential oil, numerous biological and pharmacological activities were reported, such as antioxidant [12; 13], antifungal [14], and antispasmodic activity [15]; being a natural and alternative antibacterial agent [16]; neuroprotective effects; anti-inflammatory effects with high potency against COX-1; and a reduction of the effects of ischemia [17]. In addition, the essential oil extracted from seeds was known for therapeutic virtues, such as being antiangiogenic [18], anticancer, and antifungal, and presenting an insecticidal effect [19]. Moreover, other beneficial effects well known in folk medicine have been manifested against diseases, such as the treatment of eczema, pimples and sores [13; 20], hepatitis [21], hair loss, cough, fever [22], poisoning, and vomiting, as well as the healing of external wounds [23] and use as a relaxation agent [6; 8; 18]. Recently, [PERSON] et al. 2018 [24] reported on the relationship between the interpopulation chemotype variation and genetic diversity of _Artemisia herba-alba_ growing in Tunisia, using for discrimination the PCA (principal component analysis) method. Concerning the chemical composition, numerous studies in the literature have focused their investigation on the secondary metabolite constituents in both essential oils and extracts containing bioactive compounds. Phytochemical studies have shown their richness with new biologically active compounds that are described as promising for the treatment of cancer [25]. Among the constituents of oxygenated monoterpenes EO (75%) which present different chemical classes (alcohol, ether, ketone, ester), [PERSON] et al. (2015) [26] indicated the presence of the three predominant components (cis-chrysanthenol, 1,8-cineole; \(\alpha\)-terpinenol), accounting for 33.6%, while the remaining 41.4% is attributed to the 33 compounds that are in minority (\(\gamma\)-terpinenol; terpinen-4-ol acetate, trans-thujone, carvenone, cis-chrysanthenyl acetate, isobornyl acetate, iso-menthyl acetate, Z-jasmone... ).