## 5 Conclusions  
Although there are currently no candidate genes available for molecular targets that are useful as companion diagnoses for urologic tumors, many researchers have shown  
\begin{table}
\begin{tabular}{l l l l} \hline \hline miRNA & Target Molecules/Function & Target Cancer & Reference \\ \hline \hline miR-145 & Syndecan-1/suppressed cell proliferation & Bladder carcinoma & [25] \\ \hline miR-1826 & \(\beta\)-catenin, MEK1 & renal cell carcinoma & [37] \\ \hline miR-185 & VEGFR/ Inhibits cell proliferation and induces cell apoptosis & renal cell carcinoma & [39] \\ \hline miR-204 & Suppress tumor growth & renal cell carcinoma & [40] \\ \hline miR-224.5p & Cyclin D1/Regulates D2-L1 expression & renal cell carcinoma & [42] \\ \hline miR-497-5p & Regulates PD-L1 expression & renal cell carcinoma & [43] \\ \hline miR-107 & Tumor suppressor & renal cell carcinoma & [44] \\ \hline miR-92 & Regulates VHL gene expression & renal cell carcinoma & [46] \\ \hline miR-15a & renal cell carcinoma & [52] \\ \hline miR-20a-5p & renal cell carcinoma & [53] \\ \hline miR-30a-5p & renal cell carcinoma & [54] \\ \hline miR-96-5p & Bladder carcinoma & [73] \\ \hline miR-192 & Bladder carcinoma & [74] \\ \hline miR-214 & Bladder carcinoma & [76] \\ \hline miR-99a,125b & Bladder carcinoma & [27] \\ \hline miR-106b & Bladder carcinoma & [80] \\ \hline miR-283a & suppressed cell proliferation & Prostate carcinoma & [86] \\ \hline miR-194 & Post-transcriptional regulation & Prostate carcinoma & [87] \\ \hline miR-125-5p & NAIF1/regulates cell proliferation and migration & Prostate carcinoma & [88] \\ \hline miR-185 & Androgen receptor & Prostate carcinoma & [92] \\ \hline miR-122 & Rho associated protein kinase 2/inhibits cell proliferation & Prostate carcinoma & [93] \\ \hline miR-149-5p & RGS17/suppress cancer malignancy & Prostate carcinoma & [94] \\ \hline miR-1838,205 & Prostate carcinoma & [96] \\ \hline miR-26a & Modulates the metastasis and tumor growth & Prostate carcinoma & [99] \\ \hline miR-145 & suppressed cell proliferation & Prostate carcinoma & [100] \\ \hline miR-205, 338-3p & BCL2/Regulates cell apoptosis & Prostate carcinoma & [102] \\ \hline miR-188 & MARCS / suppressed cell proliferation & Prostate carcinoma & [103] \\ \hline miR-203 & Bladder carcinoma & [116] \\ \hline \hline \end{tabular}
\end{table}
Table 1: miRNA for molecular biomarker.  
Figure 4: The function of cancer-related proteins and miRNAs in tumor cells and the detection of target genes by genetic analysis. Tumor-associated proteins and miRNAs control cell proliferation, invasion, and prognosis. Genetic analyses of DNA/RNA in tumor cells and cell-free DNA in body fluids are effective for diagnoses and prognoses.  
that urinary miRNAs and cell-free DNA/RNA have the potential to serve as biomarkers and may be useful in predicting prognoses. It is expected that various molecular targeted therapies and tumor-specific biomarkers based on the functions of miRNAs and their target molecules will be used in practice in the future.  
[PERSON], [PERSON], [PERSON] and [PERSON] prepared the manuscript. [PERSON] critically revised the manuscript. All authors have read and agreed to the published version of the manuscript.  
This research was supported, in part, by a Grant-in-Aid from the Japanese Ministry of Education, Culture, Sports, Science, and Technology (21K06906).  
The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Institutional Review Board of Nara Medical University (#253-6).  
Patient consent was waived by disclosing the opt-out statement on our institution's website and on the bulletin board of the institution's affiliated hospital.  
The data that support the findings of this study are available from the corresponding author upon reasonable request.  
The authors declare no conflict of interest.