## 2 Materials and Methods  
### Study Design and Study Population  
This study was carried out as prospective observational research within the Cardiology Department of \"Bagdasar-Arseni\" Emergency Hospital in Bucharest, Romania. A total number of 136 patients were evaluated for enrollment in our study between January 2022 and April 2023. NSTEMI was diagnosed according to the symptoms of angina pectoris or their equivalents, elevated cardiac biomarkers, electrocardiogram with myocardial ischemia signs--without changes consistent with STEMI, and abnormal echocardiography indicating myocardial ischemia [14]. The inclusion criteria consisted of patients aged 18 and older bearing the diagnosis of NSTEMI. After implementing the exclusion criteria, which encompassed inflammatory conditions such as collagen vascular disorders, autoimmune diseases, neoplastic conditions, acute or chronic infections, severe liver and/or kidney ailments, hematological disorders, recent bleeding episodes, and radiation/chemotherapy within the preceding 30 days, a total of 98 NSTEMI patients were included in the research study. Their demographic data (age, ethnicity, and gender), anthropometric measurements (BMI--body mass index), medical history (old myocardial infarction or another disease that could interfere with our results--see the exclusion criteria above), additional cardiovascular comorbidities (arterial hypertension, diabetes mellitus, dyslipidemia, smoking, and obesity), laboratory data (complete blood count, NT-proBNP, admission and peak high sensitive troponin, admission and peak creatine kinase, and creatine kinase-MB, creatinine, AST, ALT, and LDH) were collected. The demographical, anthropometric, main clinical, and main laboratory parameters (MCV, RDW, MPV, and PDW), which we have tried to correlate with prognosis, are presented in the table below (Table 1). Regarding the diagnosis of infection, which compels us to exclude the respective patients (see exclusion criteria), we defined the presence of an infection by the following: a PSEP exceeding 300 pg/mL and increased ESR and fibrinogen. For a comprehensive blood analysis, we obtained 2 milliliters of blood through venous puncture within 10 min of the patient's arrival. The blood was subsequently analyzed using a Beckman Coulter ACT5 diff AL autoencoder to determine key hematological parameters such as MCV, RDW, MPV, and PDW. For measuring NT-proBNP, the ELISA technique was employed on a Pathfast-compact immunolyzer autoanalyzer. The laboratory's standard reference range for MCV was 7.4-10.4 fl, RDW was 11.5-15.5%, MPV was 7.4-10.4 fl, and PDW was 0-99%. Any disruptions in kidney function were identified by a serum creatinine level exceeding 1.3 mg/dl for men and 1.1 mg/dl for women. A heightened level of NT-proBNP, indicating cardiac decompensation, was denoted by levels exceeding 300 pg/mL. Any medication regimen the patients had been following prior to hospitalization was also recorded, with an emphasis on antihypertensive medication, oral antidiabetic agents, B-blockers, diuretics, antiagreggants, anticoagulants, and lipid-lowering agents. Upon admission to the hospital, we assessed all factors included in the GRACE (Global Registry of Acute Coronary Events) risk score, such as age, heart rate, systolic blood pressure, baseline serum creatinine level, Killip class, cardiac arrest at admission, elevated cardiac markers, and ST-segment deviation [15]. The decision for surgical revascularization was predominantly based on the characteristics of the coronary artery lesion. Factors such as the lesion's location, size, and complexity had a critical impact on determining the necessity of surgery. It is worth noting that this decision was individualized and involved the input of a diverse team of healthcare professionals, which included cardiologists and cardiac surgeons [14].