## 4 Conclusions  
Today, it is well known that the positive effects of fruit and vegetables in preventing disorders depend on the composition of the bioactive compounds they contain (Table 1) [5; 7; 166; 167; 168; 169; 170; 169; 171]. \begin{table}
\begin{tabular}{c c c} \hline \hline
**Structure** & **Activity** & **Bibliographic Reference** \\ \hline
**OCH\({}_{3}\)** & & \\
**HO** & **OH** & \\
**PH** & **OH** & \\
**Pelargonidin-3-O-glucose (4) & & \\
**HO** & **OH** & \\ \begin{table}
\begin{tabular}{c c c} \hline \hline
**Structure** & **Activity** & **Bibliographic** \\  & **Reference** \\ \hline HO & OH & Anti-inflammatory \\ HO & OH & Antiproliferative \\ HO & OH & Pro-apoptosis Antigenotoxic \\ HO & OH & Anti-inflammatory \\ HO & OH & Pro-apoptosis Antigenotoxic \\ \hline \hline \end{tabular}
\end{table} 
Table 1: _Cont._In particular, among them, pomergnate emerges, as well as nutritional resources, for its extensively documented health properties in several application fields (neoplastic, cardiovascular, viral, inflammatory, etc.) that make it a promising tool in medicinal treatments (Table 2). \begin{table}
\begin{tabular}{c c c} \hline \hline
**Structure** & **Activity** & **Bibliographic Reference** \\ \hline
**HO** & **OH** & **OH** \\
**Vitamin A or retinol (14) & & \\
**HO** & **OH** & **Antioxidant** & **[**20**]** \\
**Vitamin C or ascorbic acid (15) & & \\
**HO** & **OH** & **Antidiabetics** & **[**5**]** \\
**OH** & **OH** & **Anti-inflammatory** & **[**5**]** \\
**Caffeic acid (17) & & \\
**COOH** & & **Antimicrobial** & **[**110**]** \\
**HO** & **OH** & **Anti**icrobial** & **[**18**]** \\
**OH** & **OH** & **Hevention of cardiovascular diseases** & **[**18**]** \\
**Gallic acid (18) & & \\ \hline \hline \end{tabular}
\end{table} 
Table 1: Cont. _Appl. Sci._**2020**, _10_, 6915 \begin{table}
\begin{tabular}{c c c} \hline \hline
**Pomegranate Extracts** & **Properties** & **References** \\ \hline
**Juice** & & ROS & [23; 25; 26; 32] \\
**Peel (PPE)** & & ROS & [25; 27; 28; 29; 30; 31] \\
**Seed** & Radical scavenging & [24; 25; 32] \\ \hline
**Anticancer properties** & & \\ \multirow{2}{*}{**Fruit (PoMx)**} & Reverse tamoxifen resistant & [61] \\  & Inhibition of cell proliferation and metastasis & \\  & (HSC-3) & [62] \\
**Husk** & Inhibition of cell proliferation (HepG2 and & \\  & CACO) & [68] \\
**Juice** & Inhibition of cell proliferation (HT-29) & [5] \\  & Inhibition of cell proliferation (HeLa) & \\
**Leaf** & & Necrosis & [75] \\  & Apoptosis & \\  & Inhibition of cell proliferation (MCF-7 and & \\  & HCT-116) & [67] \\  & Inhibition of cell proliferation (MCF-7, & \\
**Peel** & & SKOV3, PC3 and A549) & [69] \\  & Inhibition of cell proliferation (K562) & \\  & Cell cycle G2/M & [70] \\  & Apoptosis & \\  & Inhibition of cell proliferation (HONE1) & [76] \\
**Seed** & Inhibition of cell proliferation (HepG2 and & [68] \\
**Seedless arid** & Inhibition of cell proliferation (LAPC4) & [59] \\  & Inhibition of cell proliferation (MCF-7 and & \\  & LAPC4) & [59] \\  & Apoptosis & \\
**Skin (PoPx)** & Inhibition of cell proliferation (MCF-7) & \\  & Antiangiogenic & [60] \\  & Inhibition of cell invasion and motility & \\  & Inhibition of cell proliferation (melanocyte) & \\  & Free radicals block in UVA and UVB & [63; 64] \\  & irradiated human skin & \\  & Inhibition of cell proliferation (WA-4) & \\  & Cell cycle arrest G0/G1 & [65] \\
**Whole extract (PE)** & Apoptosis & \\  & Inhibition of cell proliferation (PANC-1 and & \\  & AsPC-1) & [66] \\  & Cell cycle arrest G2 & \\  & Immunomodulatory effects in stem cells & [71] \\ \hline \hline \end{tabular}
\end{table} 
Table 2: Biological properties of different pomergnate extracts. \begin{table}
\begin{tabular}{c c c} \hline \hline
\begin{tabular}{c} **Peel (PPE)** \\ **Seed** \\