# Cross Talk between Synthetic Food Colors (Azo Dyes), Oral Flora, and Cardiovascular Disorders
## 2 Food Colors, Oral Flora and Cardiovascular Disorders
### Oral Flora and Periodontal Disease
#### 2.3.3 Role of Oral Flora in Periodontal Disease
gordonii_) that contribute to periodontal disease [49], the Fusobacterium species also plays an important role in causing different diseases. The Gram-negative bacterium is implicated in periodontal disease. Fusobacterium is the most common bacteria, according to the literature survey. Fusobacterium is one of the first bacteria that was spotted in the accumulation of dental plaque biofilms. It is considered to be one of most common species isolated from extra-oral infections [50]. Oral microbiota not only cause cardiovascular disorders but are also involved in cancer and other systematic diseases. Increasing evidence supports an association between oral cancer and oral microbiomes, such as oral squamous cell carcinoma. A systematic understanding of such an association may originate from the ability of various microorganisms to alter the inflammatory microhabitat and to restrain host signalling pathways that control cell viability, proliferation, and differentiation. Peculiarly, the influence of the oral microbiome can expand beyond the oral cavity and can cause \begin{table}
\begin{tabular}{c c c c c} \hline \hline \multicolumn{5}{c}{**Human Oral Flora**} \\ \hline
**Phyla** & **Class** & **Order** & **Family** & **Genera** \\ \hline \multirow{4}{*}{**Proteobacteria**} & Gammaproteobacteria & Pasteurellales & Pasteurellaceae & _Aggregatibacter_ \\  & Gammaproteobacteria & Pasteurellales & Pasteurellaceae & _Haenophilus_ \\  & Epsilonproteobacteria & Campylobacteraceae & _Campylobacyaceae_ & _Campylobacyaceae_ \\  & Betaproteobacteria & Neisseria & Neisseriaceae & _Kingella_ \\  & Betaproteobacteria & Neisseria & Nrisseriaceae & _Neisseria_ \\ \hline \multirow{4}{*}{**Bacteroidetes**} & Falvobacteria & Flavobacteriales & Flavobacteriaceae & _Campocytophaga_ \\  & Bacteroidia & Bacteroidales & Porphyromonadaceae & _Porphyromonas_ \\  & Bacteroidia & Bacteroidales & Prevotellaceae & _Prevotella_ \\  & Bacteroidetes & Bacteroidales & Porphyromonadaceae & _Tannerella_ \\ \hline \multirow{4}{*}{**Actinobacteria**} & Actinobacteria & Actinomycetes & Actinomycetaceae & _Actinomyces_ \\  & Actinobacteria & Bifidobacteriales & Bifidobacteriaceae & _Bifidobacterium_ \\  & Coriobacteria & Eggerthellales & Eggerthellaceae & _Slackia_ \\ \hline \multirow{4}{*}{**Spirochaetes**} & Spirochaeta & Brachyspirales & Brachyspiraceae & _Brachyspira_ \\  & Spirochaeta & Brevinematales & Brevinemataceae & _Brevinema andersonii_ \\  & Spirochaeta & Leptospirales & Leptospiraceae & _Leptospira_ \\  & Spirochaeta & Spirochaeta & Spirochaeta & _Spirochaeta_ \\ \hline \multirow{2}{*}{**Fusobacteria**} & Fusobacteria & Fusobacteriales & Fusobacteriaceae & _Fusobacterium_ \\  & Fusobacteria & Fusobacteriales & Leptotrichiaceae & _Lodottricchia_ \\ \cline{1-1}  & Fusobacteria & Fusobacteriales & Fusobacteriaceae & _Fusobacterium_ \\ \hline \hline \end{tabular}
\end{table} 
Table 1: Cont. different diseases, such as coronary artery disease, the preterm delivery of low-birth weight neonates, and rheumatoid arthritis.