## 2 Materials and Methods
### Chemistry
13C NMR (DMSO-d6, 100 MHz) & 21.63 (C1-CH3400 MHz) \(\delta\): 2.49 (s, 3H, C1-CH3), 7.19-7.21 (d, 2H, J = 8.4 Hz, H2\({}^{\prime}\), H6\({}^{\prime}\)), 7.47-7.49 (d, 2H, J = 8.8 Hz, H2, H6), 7.63-7.65 (d, 2H, J = 8.8 Hz, H3\({}^{\prime\prime}\), H5\({}^{\prime\prime}\)), 7.66-7.69 (d, 2H, J = 8.8 Hz, H2\({}^{\prime\prime}\), H6\({}^{\prime\prime}\)), 7.76-7.79 (d, 2H, J = 8.4 Hz, H3, H5), 7.90-7.92 (d, 2H, J = 8.4 Hz, H3\({}^{\prime}\), H5\({}^{\prime}\)), 8.40 (s, 1H, N=CH), 11.91 (s, 1H, CONH). 13C NMR (DMSO-d6, 100 MHz) \(\delta\): 21.16 (C1-CH3), 122.12 (C2\({}^{\prime}\), C6\({}^{\prime}\)), 123.40 (C4\({}^{\prime\prime}\)), 128.23 (C4\({}^{\prime}\)), 128.96 (C2\({}^{\prime\prime}\), C6\({}^{\prime\prime}\)), 129.67 (C3, C5), 130.30 (C2, C6), 131.20 (C4), 131.82 (C3\({}^{\prime\prime}\), C5\({}^{\prime\prime}\)), 132.33 (C3\({}^{\prime}\), C5\({}^{\prime}\)), 133.46 (C1\({}^{\prime\prime}\)), 146.00 (C1), 146.82 (N=CH), 151.12 (C1\({}^{\prime}\)), 162.03 (C=O). MS (ESI) \(m/z\) calcd. for C21H17 BrN2O4S [M+472.01, found 472.04. _N\({}^{\prime}\)-[(2-Chlorophenyl)methylidene)]-4-[(4-methylphenyl)sulfonyl]benzoylhydrazizide_ (**3k**). Yield 98.9%. mp 188.8-189.2 \({}^{\circ}\)C. HPLC tR: 11.096 min, purity: 99.47%. 1H NMR (DMSO-d6, 400 MHz) \(\delta\): 2.40 (s, 3H, C1-CH3), 7.18-7.20 (d, 2H, J = 8.4 Hz, H2\({}^{\prime}\), H6\({}^{\prime}\)), 7.41-7.51 (m, 3H, H3\({}^{\prime\prime}\), H4\({}^{\prime\prime}\), H5\({}^{\prime\prime}\)), 7.45-7.47 (d, 2H, J = 8.8 Hz, H3\({}^{\prime}\), H5\({}^{\prime}\)), 7.75-7.77 (d, 2H, J = 8.0 Hz, H2, H6), 7.91-7.93 (d, 2H, J = 8.4 Hz, H3, H5), 7.98-8.00 (d, 1H, J = 7.2 Hz, H6\({}^{\prime\prime}\)), 8.81 (s, 1H, N=CH), 12.09 (s, 1H, CONH). 13C NMR (DMSO-d6, 100 MHz) \(\delta\): 21.63 (C1-CH3), 122.61 (C2\({}^{\prime}\), C6\({}^{\prime}\)), 127.32 (C3\({}^{\prime\prime}\)), 128.06 (C5\({}^{\prime\prime}\)), 128.70 (C4\({}^{\prime}\)), 130.17 (C3, C5), 130.37 (C6\({}^{\prime\prime}\)), 130.76 (C2, C6), 131.64 (C4), 131.88 (C4\({}^{\prime\prime}\)), 132.02 (C1\({}^{\prime\prime}\)), 132.63 (C3\({}^{\prime}\), C5\({}^{\prime}\)), 133.69 (C2\({}^{\prime\prime}\)), 144.45 (N=CH), 146.47 (C1), 151.76 (C1\({}^{\prime}\)), 162.48 (C=O). MS (ESI) \(m/z\) calcd. for C21H17 ClN2O4S [M+2H]+ 430.07, found 429.91. _N\({}^{\prime}\)-[(3-Chlorophenyl)methylidene)]-4-[(4-methylphenyl)sulfonyl]benzoylhydrazizide_ (**31**). Yield 98.7%. mp 141.7-142.2 \({}^{\circ}\)C. HPLC tR: 10.518 min, purity: 98.96%. 1H NMR (DMSO-d6, 400 MHz) \(\delta\): 2.42 (s, 3H, C1-CH3), 7.19-7.21 (d, 2H, J = 8.8 Hz, H2\({}^{\prime}\), H6\({}^{\prime}\)), 7.47-7.49 (d, 4H, J = 8.4 Hz, H2, H6, H4\({}^{\prime\prime}\), H6\({}^{\prime\prime}\)), 7.68 (s, 1H, H5\({}^{\prime\prime}\)), 7.76-7.78 (d, 3H, J = 8.4 Hz, H3, H5, H2\({}^{\prime\prime}\)), 7.90-7.92 (d, 2H, J = 7.6 Hz, H3\({}^{\prime}\), H5\({}^{\prime}\)), 8.40 (s, 1H, N=CH), 11.98 (s, 1H, CONH). 13C NMR (DMSO-d6, 100 MHz) \(\delta\): 21.16 (C1-CH3), 129.72 (C3, C5), 129.78 (C4\({}^{\prime\prime}\)), 130.31 (C5\({}^{\prime\prime}\)), 130.72 (C2, C6), 131.19 (C4), 132.24 (C3\({}^{\prime}\), C5\({}^{\prime}\)), 133.64 (C1\({}^{\prime\prime}\)), 136.42 (C3\({}^{\prime\prime}\)), 146.02 (C1), 146.38 (N=CH), 151.27 (C1\({}^{\prime}\)), 162.14 (C=O). MS (ESI) \(m/z\) calcd. for C21H17 ClN2O4S [M]+ 428.05. _N\({}^{\prime}\)-[(4-Chlorophenyl)methylidene)]-4-[(4-methylphenyl)sulfonyl]benzoylhydrazizide_ (**3m**). Yield 91.2%. mp 201.8-202.4 \({}^{\circ}\)C. HPLC tR: 10.485 min, purity: 99.13%. 1H NMR (DMSO-d6, 400 MHz) \(\delta\): 2.48 (s, 3H, C1-CH3), 7.17-7.19 (d, 2H, J = 8.4 Hz, H2\({}^{\prime}\), H6\({}^{\prime}\)), 7.21-7.74 (d,2H, J = 8.8 Hz, H2\({}^{\prime\prime}\), H6\({}^{\prime\prime}\)), 7.45-7.47 (d, 2H, J = 8.4 Hz, H3\({}^{\prime\prime}\), H5\({}^{\prime\prime}\)), 7.48-7.50 (d, 2H, J = 8.8 Hz, H2, H6), 7.75-7.77 (d, 2H, J = 8.4 Hz, H3\({}^{\prime\prime}\), H5\({}^{\prime}\)), 8.39 (s, 1H, N=CH), 11.93 (s, 1H, CONH).