# Classification of Alzheimer's Disease Based on White Matter Connectivity Network
## 3 Results and Discussion
### Feature Extraction  
Figure 5 shows the cross-validation scores of the feature factor RFE between the MCI and NC groups. As can be seen from the figure, the left gyrus rectus had the highest score, the model had the best performance, and the prediction accuracy was 81.67%. Several brain regions with higher scores were highly correlated with visual function, so it is hypothesized that there may be a direct or indirect relationship between the degradation of visual function and cognitive dysfunction in patients with MCI, which is consistent with previous studies on the association of visual networks with cognitive dysfunction [38]. It also reveals that the MCI stage is already potentially at risk for impaired motor levels. Figure 6 shows the cross-validation scores after the RFE of the trait factors between the MCI and AD groups. As can be seen from the figure, the right thalamus has the highest score, the model had the best performance, and the prediction accuracy was 86.92%. The several brain regions with higher scores are highly correlated with motor and sensory functions. Therefore, we believe that the decrease in motor ability in AD patients may be affected by changes in the WM fiber bundle, and during the MCI stage, the fiber bundle may have partially changed, but not enough to affect the patient's motor level. At the  
Figure 5: Cross-validation scores of eigenvectors between MCI and NC groups. \begin{table}
\begin{tabular}{c c c c} \hline \hline
**Mricro Name** & **MCI** & **AD** & \(\boldsymbol{p}\)**-Value** \\ \hline Putamen\_L & 0.48 \(\pm\) 0.13 & 0.26 \(\pm\) 0.25 & 3.31 \(\times\) 10\({}^{-6}\) \\ Putamen\_R & 0.47 \(\pm\) 0.15 & 0.25 \(\pm\) 0.26 & 1.27 \(\times\) 10\({}^{-5}\) \\ Thalamus\_L & 0.43 \(\pm\) 0.17 & 0.21 \(\pm\) 0.24 & 5.55 \(\times\) 10\({}^{-6}\) \\ Thalamus\_R & 0.41 \(\pm\) 0.19 & 0.20 \(\pm\) 0.24 & 3.39 \(\times\) 10\({}^{-5}\) \\ Supp\_Motor\_Area\_L & 0.41 \(\pm\) 0.07 & 0.27 \(\pm\) 0.19 & 2.49 \(\times\) 10\({}^{-5}\) \\ Supp\_Motor\_Area\_R & 0.39 \(\pm\) 0.15 & 0.19 \(\pm\) 0.22 & 5.17 \(\times\) 10\({}^{-6}\) \\ caudate\_L & 0.31 \(\pm\) 0.23 & 0.11 \(\pm\) 0.20 & 7.11 \(\times\) 10\({}^{-5}\) \\ Caudate\_R & 0.47 \(\pm\) 0.13 & 0.28 \(\pm\) 0.26 & 5.10 \(\times\) 10\({}^{-5}\) \\ Precuneus\_L & 0.36 \(\pm\) 0.16 & 0.17 \(\pm\) 0.21 & 1.05 \(\times\) 10\({}^{-5}\) \\ Frontal\_Sup\_Medial\_L & 0.41 \(\pm\) 0.07 & 0.27 \(\pm\) 0.19 & 2.49 \(\times\) 10\({}^{-5}\) \\ Hippocampus\_L & 0.47 \(\pm\) 0.17 & 0.26 \(\pm\) 0.27 & 2.93 \(\times\) 10\({}^{-5}\) \\ Pallidum\_L & 0.41 \(\pm\) 0.22 & 0.19 \(\pm\) 0.25 & 3.41 \(\times\) 10\({}^{-5}\) \\ Cingulum\_Post\_L & 0.30 \(\pm\) 0.25 & 0.08 \(\pm\) 0.18 & 4.02 \(\times\) 10\({}^{-5}\) \\ Insula\_R & 0.39 \(\pm\) 0.15 & 0.19 \(\pm\) 0.22 & 5.17 \(\times\) 10\({}^{-6}\) \\ Frontal\_Inf\_Oper\_R & 0.37 \(\pm\) 0.06 & 0.24 \(\pm\) 0.19 & 3.33 \(\times\) 10\({}^{-5}\) \\ Frontal\_Sup\_R & 0.37 \(\pm\) 0.06 & 0.24 \(\pm\) 0.19 & 3.33 \(\times\) 10\({}^{-5}\) \\ \hline \hline \end{tabular}
\end{table} 
Table 3: Nodes with significant differences in FA values between the MCI and AD groups. same time, declines in sensory abilities, and a wide range of brain functions including sensory processing, attention, decision-making, and memory, are consistent with the early symptoms exhibited by AD patients [39]. The features selected for the RFE between the MCI and NC groups were the left supplementary motor area-right thalamus, left medial superior frontal gyrus-left posterior cingulate gyrus, right insula-right supplementary motor area, right insula-left lenticular nucleus, right insula-left pallidum lenticular nucleus, and right dorsolateral superior frontal gyrus-right opercular part inferior frontal gyrus.