## 3 Results
### Modulation of Cytotoxicity
\begin{table}
\begin{tabular}{c c c c c c c} \hline \hline
**Type of Habanero** & **MCF-7/Sens \({}^{\text{a}}\)** & **MCF-7/Sens \({}^{\text{a}}\)** & **MCF-7/Vin- \({}^{\text{c}}\)** & **MCF-7/Vin- \({}^{\text{c}}\)** & **RF** \\
**By-Product or Drug \({}^{\text{a}}\)** & **IC0s (ug mL-1)** & **IC0s (ug mL-1)** & **IC0s (ug mL-1)** & **IC0s (ug mL-1)** & **RF** \\ \hline PBS ME & 0.0022 \(\pm\) 0.0006 & 32.95 \({}^{\text{med}}\) & 0.46 \(\pm\) 0.02 & 3.80 \({}^{\text{h}}\) & 0.32 \(\pm\) 0.07 \({}^{\text{s}}\) & 5.77 \({}^{\text{b}}\) \\ \hline LBS ME & 0.0470 \(\pm\) 0.0023 & 4.95 \({}^{\text{a}}\) & 0.38 \(\pm\) 0.01 & 4.49 \({}^{\text{b}}\) & 0.36 \(\pm\) 0.02 \({}^{\text{s}}\) & 5.06 \({}^{\text{b}}\) \\ \hline SBS ME & 0.0014 \(\pm\) 0.0003 & 51.79 \({}^{\text{h}}\) & 2.01 \(\pm\) 0.33 & 0.87 \({}^{\text{th}}\) & 0.23 \(\pm\) 0.04 \({}^{\text{s}}\) & 7.78 \({}^{\text{a}}\) \\ \hline PRS ME & 0.0010 \(\pm\) 0.0006 & 72.50 \({}^{\text{b}}\) & 0.56 \(\pm\) 0.04 & 3.15 \({}^{\text{b}}\) & 0.95 \(\pm\) 0.07 & 1.94 \({}^{\text{a}}\) \\ \hline LBS ME & 0.0002 \(\pm\) 0.00002 & 362.50 \({}^{\text{a}}\) & 0.61 \(\pm\) 0.02 & 2.85 \({}^{\text{d}}\) & 0.55 \(\pm\) 0.05 & 3.33 \({}^{\text{c}}\) \\ \hline SRS ME & 0.0002 \(\pm\) 0.00004 & 362.50 \({}^{\text{a}}\) & 0.59 \(\pm\) 0.02 & 2.93 \({}^{\text{a}}\) & 0.89 \(\pm\) 0.02 & 2.06 \({}^{\text{a}}\) \\ \hline LBS SFE & 0.0045 \(\pm\) 0.0012 & 16.11 \({}^{\text{a}}\) & 3.74 \(\pm\) 0.29 & 0.47 \({}^{\text{h}}\) & 1.73 \(\pm\) 0.21 & 1.07 \({}^{\text{a}}\) \\ \hline SBS SFE & 0.2213 \(\pm\) 0.0065 & 0.33 \({}^{\text{d}}\) & 0.43 \(\pm\) 0.14 & 4.05 \({}^{\text{b}}\) & 0.28 \(\pm\) 0.09 & 6.59 \({}^{\text{th}}\) \\ \hline SBS SFE & 0.0141 \(\pm\) 0.0031 & 5.14 \({}^{\text{d}}\) & 0.72 \(\pm\) 0.16 & 2.40 \({}^{\text{d}}\) & 1.84 \(\pm\) 0.23 & 1.00 \({}^{\text{a}}\) \\ \hline LBS SOX & 0.0084 \(\pm\) 0.0017 & 8.63 \({}^{\text{d}}\) & 0.94 \(\pm\) 0.05 & 1.85 \({}^{\text{a}}\) & 1.48 \(\pm\) 0.06 & 1.24 \({}^{\text{d}}\) \\ \hline SBS SOX & 0.0069 \(\pm\) 0.0010 & 10.51 \({}^{\text{a}}\) & 1.12 \(\pm\) 0.14 & 1.56 \({}^{\text{th}}\) & 1.19 \(\pm\) 0.35 & 1.54 \({}^{\text{d}}\) \\ \hline SRS SOX & 0.0036 \(\pm\) 0.0006 & 20.35 \({}^{\text{a}}\) & 0.46 \(\pm\) 0.10 & 3.75 \({}^{\text{b}}\) & 1.96 \(\pm\) 0.07 & 0.94 \({}^{\text{a}}\) \\ \hline Reserpine \({}^{\text{a}}\) & 0.0022 \(\pm\) 0.0001 & 32.95 \({}^{\text{b}}\) & 0.078 \(\pm\) 0.01 & 22.42 \({}^{\text{a}}\) & 0.58 \(\pm\) 0.05 & 3.14 \({}^{\text{c}}\) \\ \hline Vinblastine & 0.0725 \(\pm\) 0.0028 & & 1.75 \(\pm\) 0.03 & & 1.84 \(\pm\) 0.02 & \\ \hline \hline \end{tabular} \({}^{\text{a}}\) Serial dilutions from 0.000128 to 2 ug mL-1 of vinblastine in the presence or absence of extract (25 ug mL-1); P = pedundes; L = leaves; S = stems; BS = black soil; RS = red soil; ME = extraction by maceration; SFE = supercritical fluid extraction; SOX = extraction by Soxhet; \({}^{\text{b}}\) MCF-7/Sens = sensitive or parental breast cancer cells; \({}^{\text{c}}\) MCF-7/Vin- = resistant breast cancer cells that grow up in the absence of vinblastine. \({}^{\text{b}}\) MCF-7/Vin- = resistant breast cancer cells that grow up in the presence of 0.19 ug mL-1 of vinblastine). \({}^{\text{b}}\) MCF-7/Vin- = resistant breast cancer cells that grow up in the presence of extract). \({}^{\text{b}}\) RF = reversal factor (IC0s; vinblastine/IC0s vinblastine in the presence of extract). \({}^{\text{b}}\) Reserpine = 5 ug mL-1 as positive control; each value represents the mean \(\pm\) SD of three independent experiments. \({}^{\text{a-h}}\) Different superscript letters in the same row indicates statistically significant differences (\(p\leq 0.05\)).  
\end{table} 
Table 1: Modulating effect of the cytotoxic activity of hbanero by-product extracts on human cell lines of breast cancer, parental and resistant to vinblastine. Figure 3: Modulation assay of vinblastine with leaves and stems of plants grown on red soil extracts obtained using maceration against MCF-7/Sens parental cell line.