## 5 Conclusions  
Micellized naringenin, when delivered intra-myocardially at the time of MI, suppresses tubulin detyrosination, increases cardiomyocyte cotraction and relaxation velocity, and improves ejection fraction one day after MI in rats. Micellized naringenin merits further investigation as a potential treatment for post-MI cardiogenic shock.  
**Supplementary Materials:** The following supporting information can be downloaded at [[https://www.mdpi.com/article/10.3390/app142411936/s1](https://www.mdpi.com/article/10.3390/app142411936/s1)]([https://www.mdpi.com/article/10.3390/app142411936/s1](https://www.mdpi.com/article/10.3390/app142411936/s1)). Figure S1: Transmission electron microscopy image of naringenin-loaded micelles; Figure S2. FTIR spectra for naringenin-loaded micelles (NarMic), naringenin and PEG-PCL micelle physical mixture (Nar+PEG-PCL), PEG-PCL micelle alone (PEG-PCL), and naringenin alone (Nar). References [26, 27] are cited in the Supplementary Materials.  
**Author Contributions:** Conceptualization, N.W., A.I., A.A., Z.C., A.T. and P.A.; methodology, N.W., A.I., J.D., D.M., A.B., S.G.-P., A.A., D.N., B.W.L., D.M.E. and K.B.M.; software, K.B.M., Z.C., A.T. and P.A.; validation, B.W.L., D.M.E., K.B.M., Z.C., A.T. and P.A.; formal analysis, N.W., A.I., J.D., D.M., A.B., S.G.-P., R.W., J.H., C.K., A.A. and D.N.; investigation, N.W., A.I., J.D., D.M., A.B., S.G.-P., R.W., [PERSON], C.K., A.A. and D.N.; resources, K.B.M., Z.C., A.T. and P.A.; data curation, N.W., A.I., J.D., D.M., A.B., S.G.-P., R.W., [PERSON], C.K., A.A. and D.N.; writing--original draft preparation, N.W., A.I., J.D., A.A., D.N. and P.A.; writing--review and editing, N.W., A.I., J.D., D.M., A.B., S.G.-P., R.W., [PERSON], C.K., A.A., D.N., B.W.L., D.M.E., K.B.M., Z.C., A.T. and P.A.; visualization, N.W., J.D., D.M., A.B., S.G.-P., R.W. and J.H.; supervision, K.B.M., Z.C., A.T. and P.A.; project administration, J.D.; funding acquisition, N.W., K.B.M., Z.C., A.T. and P.A. All authors have read and agreed to the published version of the manuscript.  
**Funding:** This research was funded by the American Association for Thoracic Surgery Foundation, Cardiac Surgical Resident Investigator Award (2022-2023), and by the National Institute of Health, R01 (Project #1R01 HL135090-01A1).  
**Institutional Review Board Statement:** The animal study protocol was approved by the Institutional Animal Care and Use Committee of the University of Pennsylvania (protocol #806689 and date of approval: 14 March 2022).  
**Informed Consent Statement:** Not applicable.  
**Data Availability Statement:** All data used in this study can be obtained via email request sent to the corresponding author. The data are not publicly available due to proprietary considerations.  
**Acknowledgments:** We acknowledge the University of Pennsylvania and its Departments of Surgery, Bioengineering, and Medicine for providing the facilities, equipment, and other resources that were critical for completing the studies described herein.  
**Conflicts of Interest:** The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.