# Extracellular Vesicles for Regenerative Medicine Applications
## 4 Clinical Development of EVs
### Clinical Trials Testing EV Therapies
\begin{table}
\begin{tabular}{c c c c} \hline
**NCT Number** & **Study Description** & **Status** & **Patients** \\ \hline \multicolumn{4}{c}{_Phase 1_} \\ \hline \multirow{3}{*}{NCT01668849} & Edible plant exosome ability to prevent oral & \multirow{3}{*}{Active, not recruiting} & \multirow{3}{*}{60} \\  & mucositis associated with chemoradiation treatment & & \\  & of head and neck cancer & & \\ \hline \multirow{3}{*}{NCT04276987} & Pilot clinical study investigating inhalation of & \multirow{3}{*}{Completed} & \multirow{3}{*}{24} \\  & MSC-derived exosomes for the treatment of severe & & \\  & COVID-19 pneumonia & & \\ \hline \multirow{3}{*}{NCT04313647} & Clinical study assessing tolerance of aerosolized & \multirow{3}{*}{Completed} & \multirow{3}{*}{24} \\  & inhalation of MSC-derived exosomes in & & \\  & healthy volunteers & & \\ \hline \multirow{3}{*}{NCT04134676} & Study assessing the therapeutic potential of stem cell & \multirow{3}{*}{Completed} & \multirow{3}{*}{38} \\  & conditioned medium on chronic ulcer wounds. & & \\ \hline \multirow{3}{*}{NCT04849429} & Investigation of intra-discal injection of platelet-rich & \multirow{3}{*}{Recruiting} & \multirow{3}{*}{30} \\  & plasma (PRP) enriched with exosomes in chronic & & \\  & low back pain & & \\ \hline \multirow{3}{*}{NCT01294072} & Study investigating the ability of plant exosomes to & \multirow{3}{*}{Recruiting} & \multirow{3}{*}{35} \\  & deliver curcumin to normal and colon cancer tissue & & \\ \hline \multirow{3}{*}{NCT04747574} & Evaluation of the safety of CD24-derived exosomes & \multirow{3}{*}{Recruiting} & \multirow{3}{*}{35} \\  & in patients with COVID-19 infection & & \\ \hline \multirow{3}{*}{NCT03608631} & Exosomes in treating participants with metastatic & \multirow{3}{*}{Recruiting} & \multirow{3}{*}{28} \\  & pancreas cancer with KRAS G1D mutation & & \\ \hline \multirow{3}{*}{NCT05387278} & Safety and efficacy of placental-derived exosomes & \multirow{3}{*}{Recruiting} & \multirow{3}{*}{20} \\  & and umbilical cord mesenchymal stem cells (UMSC) & & \\ \cline{1-1}  & in moderate to severe acute respiratory distress & & \\ \cline{1-1}  & syndrome (ARDS) associated with & & \\ \cline{1-1}  & COVID-19 infection & & \\ \hline \multirow{3}{*}{NCT05375604} & A study of exoASO-STAT6 (CDK-004) in patients & \multirow{3}{*}{Recruiting} & \multirow{3}{*}{30} \\  & with advanced hepatocellular carcinoma (HCC) and & & \\ \cline{1-1}  & patients with liver metastases from primary gastric & & \\ \cline{1-1}  & cancer and colorectal cancer (CRC) & & \\ \hline \multicolumn{4}{c}{_Phase 1/II_} \\ \hline NCT04384445 & Zofin (organicell flow) for patients with COVID-19 & Active, not recruiting & 20 \\ \hline NCT04491240 & Evaluation of safety and efficacy of exosome & \multirow{3}{*}{Completed} & \multirow{3}{*}{30} \\  & inhalation in COVID-19-associated pneumonia. & & \\ \hline NCT05402748 & Safety and efficacy of human placenta MSC derived & \multirow{3}{*}{Recruiting} & \multirow{3}{*}{80} \\  & exosomes for the treatment of complex anal fistulas & & \\ \hline \multirow{3}{*}{NCT03384433} & Assessment of using allogenic mesenchymal stem & \multirow{3}{*}{Recruiting} & \multirow{3}{*}{5} \\  & cell derived exosomes in patients with acute & & \\ \cline{1-1}  & ischemic stroke & & \\ \hline \end{tabular}
\end{table} 
Table 2: Clinical trials investigating EV-based therapies.