# Propolis as Natural Product in the Oral Cavity Bacterial Infections Treatment: A Systematic Review
###### Abstract
\begin{table}
\begin{tabular}{c c} \hline
**Disease** & **Bacteria** \\ \hline \multirow{10}{*}{Caries} & _Actinomyces israelii_[4; 5], _Actinomyces naeslundii_[6], _Actinomyces odontylticus_[7], _Actinomyces viscosous_[6], _Alexandrium mintum_[8; 9], _Bacteroides oatus_[8; 10], _Bifidobacterium longum_[4; 11], _Bifidobacterium aoldescentis_[4; 11], _Clostidium ransosum_[4; 12], _Clostidium perfessions_[4; 12], _Eibiella cordendens_[7], _Fusobacterium uncalatum_[7], _Lactobacillus actinolulus acidophilus_[7], _Lactobacillus fermentum_[8; 10], _Peptonophilus asacachrolyticus_[16; 17], _Peptonofibulos asachrolyticus_[16; 17], _Peptostreptococcus micross_[18; 19], _Porphyromonas endodontalis_[6], _Porphyromonas gingivalis_[6], _Prevotella melaninogenica_[18; 19], _Prevotella dentica_[6], _Staphylococcus aureus_[8; 20], _Streptococcus crietus_[21], _Streptococcus mittis_[7], _Streptococcus mutans_[21], _Streptococcus salivarius_[15; 15], _Streptococcus sapiunits_[6; 22] \\ \hline \multirow{10}{*}{Periodontitis} & _Actinomyces israelii_[23], _Actinomyces naeslundii_[6; 24], _Actinomyces viscosous_[6; 24], _Campylobacter gracilis_[23], _Clostidium perfrigens_[23] \\ \cline{2-3}  & _Actinomyces israelii_[25], _Actinomyces naeslundi_[25], _Actinomyces odontylticus_[7], _Aggregatighter actinolomelectomentiments_[26], _Capmycotophaga o oleraca_[8; 25], _Eikerella corordens_[7], _Fusobacterium untaelatum_[7; 27], _Fusobacterium periodoucticum_[25], _Fusobacterium urirum_[16; 28], _Lactobacillus spp._[29], _Peptostreptococcus anaerbtis_[19; 30], _Porphyromonas gingivalis_[31; 32], _Prevotella interpreachie bria_[16; 33], _Prevotella interpreachie intermedia_[27], _Prevotella nigrescenes_[25], _Streptococcus bovis_[13; 34], _Streptococcus sporodini_[35; 36], _Streptococcus internardius_[37], _Streptococcus mutans_[29], _Tanneralla forysthia_[25; 38], _Trepotococcus oralis_[38; 43], _Veillonella disrup_[43] \\ \hline \multirow{10}{*}{Pharyngitis} & _Streptococcus pyogenes_[40] \\ \cline{2-3}  & _Streptococcus sapiens_[6] \\ \cline{2-3}  & _Prevotella inermedia_[27], _Prevotella oralis_[19; 41], _Porphyromonas gingivalis_[27; 38], _Tannerella forysthia_[42] \\ \hline \multirow{10}{*}{Supragingival plaque} & _Actinomyces naslundii_[25; 43], _Fusobacterium nucleatum_[43], _Neisseria subflara_[8; 44], _Streptococcus mutans_[43], _Streptococcus oralis_[8; 43], _Veillonella disrup_[43] \\ \cline{1-1} \cline{2-3}  & _Acinomyces_ naslundii_[25; 43], _Fusobacterium nucleatum_[43], _Neisseria subflara_[8; 44], _Streptococcus mutans_[43], _Streptococcus oralis_[8; 43], _Veillonella disrup_[43] \\ \hline \end{tabular}
\end{table} 
Table 1: Bacterial strains responsible for infections of the oral cavity. in a single dose can be considered safe. This confirms that propolis is a generally safe natural product [52]. The side effects of propolis that were observed are shown in Table 2.  
Moreover, propolis therapy may also lead to stomatitis, contact dermatitis (only 1.2-6.6% of individuals [52]), chemitis, and erythema multiforme [53]. This review aims to summarize up-to-date research on propolis as an effective substance for maintaining hygiene of the oral cavity and treatment of oral infections caused by bacteria. Therefore, we focused on the papers in which the researchers reported _in vitro_ studies on bacterial strains which caused oral cavity infections and some _in vivo_ studies which underlined the therapeutic potential of propolis.