# 2\({}^{\prime}\)-Hydroxylfavanone: A Bioactive Compound That Protects against Cancers
## 2 Role of 2\({}^{\prime}\)-Hydroxyflavanone in Various Cancers
### Pancreatic Cancer
\begin{table}
\begin{tabular}{c c c c c} \hline \hline
**Cancer Type** & **Inhibition by 2 HF** & **Reduced Expression** & \begin{tabular}{c} **Increased** \\ **Expression** \\ \end{tabular} & **Ref.** \\ \hline Prostate cancer & & PSA messenger RNA & - & [35] \\ \hline Prostate cancer & \begin{tabular}{c} Wnt/\(\beta\)-catenin signaling \\ pathway \\ \end{tabular} & \(\beta\)-catenin expression, & - & [36] \\ \hline Prostate cancer & EMT & GSK-3\(\beta\) phosphorylation & - & [36] \\ \hline Prostate cancer & \begin{tabular}{c} Aldo-keto reductase family 1 \\ member C3(AKR1C3) \\ \end{tabular} & - & - & [37] \\ \hline Osteosarcoma & \begin{tabular}{c} tumor growth of 143B cells \\ in vivo \\ \end{tabular} & the amount of resulting DNA content & death receptor 5 & [39] \\ \hline Osteosarcoma & - & \begin{tabular}{c} compressions of B-cell \\ lymphoma/leukemia-2 in 143B cells \\ \end{tabular} & \begin{tabular}{c} tumor necrosis \\ factor-related \\ apoptosis- \\ inducing \\ ligand \\ \end{tabular} & [39] \\ \hline Osteosarcoma & - & - & - & \begin{tabular}{c} the rise in the \\ number of \\ hypodipid \\ cells in the \\ sub-G1 phase \\ \end{tabular} & [39] \\ \hline Osteosarcoma & - & - & - & \begin{tabular}{c} cleavage poly \\ (ADP-ribose) \\ polymerase, \\ cytochrome C \\ and B-cell \\ lymphoma- \\ extra small in \\ 143 B cells \\ \end{tabular} & [39] \\ \hline Melanoma & EMT & \
\begin{tabular}{c} mesenchymal markers fibronectin and \\ vimentin \\ \end{tabular} & E-cadherin & [13] \\ \hline Melanoma & - & tumor necrosis factor \(\alpha\) & - & [17,18] \\ \hline Melanoma & - & levels of PARP-1, caspase-9, and \\ caspase-3 & - & [17] \\ \hline Melanoma & - & RLIP76 & - & [18] \\ \hline Melanoma & - & BCL2, phospho-AKT, kiof7, and survivin & - & [17,18] \\ \hline Melanoma & - & phospho-PDGFR-\(\beta\) & - & [17] \\ \hline Melanoma & - & in cell invasion and migration & - & [17,18] \\ \hline Gastric Carcinoma &
\begin{tabular}{c} activation of the STAT3 \\ pathway \\ \end{tabular} & cell viability & - & [22] \\ \hline Gastric Carcinoma & cell proliferation of MGC-803 & - & - & [22] \\ \hline Bladder Cancer & - & p-STAT3, MMP-9, p-AKT and MMP-2 & - & [46] \\ \hline Bladder Cancer & - & Invasion and migration of T24 cells & - & [46] \\ \hline \hline \end{tabular}
\end{table} 
Table 1: _Cont._3 Role of 2\({}^{\prime}\)-Hydroxyflavanone and Flavonoids in Diseases Other Than Cancers (Figure 5)  
As the dose of 2 HF increases, the proliferation of intracellular amastigotes and cellular promastigotes is inhibited in leishmaniasis. Cutaneous leishmaniasis due to both wild-type and antimony-resistant _Leishmania_ species can be treated using leishmaniasis chemotherapy by 2 HF. Oral administration of 2 HF decreases the size of the lesion and the infection index in macrophages [51]. \begin{table}
\begin{tabular}{c c c c c} \hline \hline
**Cancer Type** & **Inhibition by 2 HF** & **Reduced Expression** & **Increased Expression** & **Ref.** \\ \hline Colon Cancer & HCT116 cells to clone itself & - & nonsteroidal anti-inflammatory drug-activated gene 1 due to activation of Egr-1 & [48] \\ \hline Pancreatic Cancer & Tumor growth & cyclin D1 and Bcl2 (an apoptosis inhibiting marker) & p27 (a cell cycle-inhibiting maker) and Bax (an apoptosis-promoting maker) & [34] \\ \hline Pancreatic Cancer & Tumour growth & cyclin D1 and Bcl2 (an apoptosis inhibiting marker) & cleavage subtype in poly-PARP and total-Caspase3 & [34] \\ \hline Pancreatic Cancer & movement and invasion of the pancreatic cancer & - & - & [34] \\ \hline \hline \end{tabular}
\end{table} 
Table 1: _Cont._  
Figure 5: Hydroxyflavanone in diseases other than cancers [51]. In rats with early portal hypertension and liver fibrosis, no significant change is observed in the hemodynamics, but 2 HF displays ease in the collaterals. This partially amplifies the apoptosis of mesenteric vascular endothelial cells [52]. Analysis of murine RAW 264.7 macrophages by flow cytometry revealed the prevention of LPS-induced macrophage apoptosis by 2 HF.