## 3 Results
### Proteomic Analysis
\begin{table}
\begin{tabular}{c c c c c c c c} \hline  & & & & & \multicolumn{2}{c}{**YA/MC**} & \multicolumn{2}{c}{**PA/MC**} \\ \hline
**Accession** & **Description** & **Protein Name** & \begin{tabular}{c} **Unique** \\ **Petides** \\ \end{tabular} & \
\begin{tabular}{c} **\(p\) Value** \\ \end{tabular} & **Ratio** &
\begin{tabular}{c} \(p\) **Value** \\ \end{tabular} & **Ratio** \\ \hline P00742 & FA10 & Coagulation factor X & 9 & \(7.7\times 10^{-4}\) & **4.8** & \(1.4\times 10^{-3}\) & **7.7** \\ P22692 & IBP4 & Insulin-like growth factor- & & 2 & \(6.7\times 10^{-2}\) & 3.9 & \(2.5\times 10^{-2}\) & **5.4** \\ Q9 UK55 & ZPI & Protein Z-dependent protease inhibitor & 7 & \(9.6\times 10^{-3}\) & **4.2** & \(6.7\times 10^{-3}\) & **5.1** \\ P01766 & HV313 & Immunoglobulin heavy & 1 & \(2.4\times 10^{-2}\) & **5.1** & \(2.8\times 10^{-2}\) & **4.5** \\ P05452 & TETN & Tetranectin & 9 & \(1.2\times 10^{-4}\) & **2.3** & \(7.1\times 10^{-6}\) & **2.8** \\ P08697 & A2 AP & Alpha-2-antiplasmin & 3 & \(6.6\times 10^{-3}\) & **2.6** & \(1.4\times 10^{-2}\) & **2.2** \\ P04196 & HRG & Histidine-rich glycoprotein & 15 & \(1.8\times 10^{-3}\) & **1.9** & \(1.2\times 10^{-3}\) & **1.9** \\ P03952 & KLKB1 & Plasma kallikrein & 16 & \(6.0\times 10^{-5}\) & **1.8** & \(5.6\times 10^{-4}\) & **1.8** \\ P00747 & PLMN & Plasminogen & 36 & \(9.4\times 10^{-6}\) & **1.9** & \(3.9\times 10^{-5}\) & **1.7** \\ P20851 & C4 BPB & C4b-binding protein beta chain & 5 & \(1.5\times 10^{-2}\) & 1.5 & \(1.6\times 10^{-3}\) & **1.7** \\ P02743 & SAMP & Serum amyloid P-component & 10 & \(4.6\times 10^{-4}\) & 1.5 & \(7.3\times 10^{-5}\) & **1.7** \\ O14791 & APOL1 & Apolipoprotein L1 & 6 & \(5.9\times 10^{-4}\) & **1.7** & \(1.0\times 10^{-3}\) & **1.6** \\ P05155 & IC1 & Plasma protease Cl inhibitor & 12 & \(4.6\times 10^{-3}\) & 1.3 & \(2.6\times 10^{-3}\) & **1.5** \\ Q13790 & APOF & Apolipoprotein F & 3 & \(1.4\times 10^{-2}\) & **1.6** & \(9.8\times 10^{-1}\) & 1.0 \\ O95445 & APOM & Apolipoprotein M & 4 & \(8.3\times 10^{-3}\) & **0.6** & \(7.8\times 10^{-1}\) & 0.9 \\ P55056 & APOC4 & Apolipoprotein C-IV & 4 & \(1.2\times 10^{-2}\) & **0.6** & \(2.2\times 10^{-1}\) & 0.8 \\ P03951 & FA11 & Coagulation factor XI & 31 & \(9.5\times 10^{-1}\) & 1.0 & \(1.2\times 10^{-2}\) & **0.7** \\ Q9 BXR6 & FHR5 & Complement factor H-related protein 5 & 5 & \(1.7\times 10^{-2}\) & **0.5** & \(9.0\times 10^{-2}\) & 0.6 \\ P81605 & DCD & Dermcidin & 5 & \(6.3\times 10^{-3}\) & **0.5** & \(3.1\times 10^{-2}\) & **0.5** \\ Q02413 & DSG1 & Desmoglien-1 & 14 & \(3.8\times 10^{-2}\) & **0.2** & \(3.4\times 10^{-1}\) & 0.5 \\ P02649 & APOE & Apolipoprotein E & 27 & \(1.9\times 10^{-3}\) & 0.5 & \(2.1\times 10^{-4}\) & **0.4** \\ Q14520 & HABP2 & Hylauronan-binding protein 2 & 16 & \(1.8\times 10^{-4}\) & **0.4** & \(7.7\times 10^{-4}\) & **0.4** \\ P35542 & SAA4 & Serum amyloid A-4 protein & 4 & \(9.4\times 10^{-5}\) & **0.4** & \(2.4\times 10^{-5}\) & **0.4** \\ P12259 & FA5 & Coagulation factor V & 6 & \(2.7\times 10^{-2}\) & **0.3** & \(8.5\times 10^{-5}\) & **0.3** \\ P06702 & S10A9 & Protein S100-A9 & 5 & \(9.8\times 10^{-2}\) & 0.2 & \(2.4\times 10^{-2}\) & **0.2** \\ P04406 & G3P & Glyceraldehyde-3-phosphate dehydrogenase & 5 & \(4.0\times 10^{-3}\) & **0.3** & \(9.6\times 10^{-4}\) & **0.2** \\ \hline \end{tabular}
\end{table} 
Table 1: Perseus comparative analysis between proteins adsorbed onto the anodized surfaces (YA and PA) versus MC. Proteins with \(p\leq 0.05\) (yellow) and a ratio greater than 1.5 (in either direction) are considered as significantly different (boldface). Proteins differentially more adsorbed (UP) are marked in red, while those less adsorbed (DOWN) appear in green. regulation, localization, multicellular organismal processes and cellular and metabolic functions (Figure 5a,a').