# Flavonoids as Promising Multitarget Agents in Alzheimer's Disease Therapy
## 1 Introduction
\begin{table}
\begin{tabular}{c c c c c c c} \hline \multicolumn{5}{c}{**Flavonoid**} & \multicolumn{2}{c}{**Mechanism of**} & \multicolumn{1}{c}{**IC\({}_{\text{50}}\)**} & \multicolumn{1}{c}{**Ref.**} \\ \hline N. & **Name** & **Log\({}^{\text{1}}\)** & **Class** & **Action** & **(\mu M)** & **Ref.** \\ \hline
**10** & (\(-\))-Kurarine & - & Flavanone & BACE1 & 3.30 & [63] \\
**11** & Lexahinone A & - & & & 8.40 & \\
**12** & Kushenol A & - & & & 2.60 & \\
**13** & (2)\(\times\)2-MethoxyVariinone & - & & & 6.70 & \\
**14** & Kushenol I & 5.85 & & & 36.80 & \\
**15** & Kurarinol & 4.80 & & & 39.20 & \\ \hline
**16** & Isoxanthohumol & 4.75 & Flavanone & BACE1 & 27.70 & [63] \\  & & & AChE & NA & [64] \\ \hline
**17** & Didymin & 2.72 & Flavanone & BACE1 & 2.34 & [59] \\  & & & AChE & 2.13 & [59] \\ \hline
**18** & Poncinin & - & Flavanone & BACE1 & 3.96 & [59] \\  & & & AChE & 12.96 & [59] \\ \hline
**19** & (\(-\))-Prunin & 0.60 & Flavanone & BACE1 & 13.41 & [59] \\  & & & AChE & 6.31 & [59] \\ \hline
**20** & (\(-\))-Hesperidin & - & Flavanone & BACE1 & 10.02 & [65] \\  & & & GSK-3B & NA & [66] \\  & & & P-IF & NE & [47] \\  & & & AChE & 22.80 & [66] \\ \hline
**21** & Neeoriocitin & - & Flavanone & BACE1 & 22.49 & [60] \\
**22** & Selagitntiflavonoid A & - & & & 0.75 & [67] \\ \hline
**23** & Cardamonin & 3.55 & Chalcone & BACE1 & 4.35 & [61] \\
**24** & 2,2,4-Thirhydroxychalcone & 2.99 & & & 2.50 & [51] \\ \hline
**25** & Xanthohumol & 5.43 & Chalcone & BACE1 & 7.19 & [68] \\  & & & AChE & 71.34 & [64] \\ \hline
**26** & Kurardiin & - & Chalcone & BACE1 & 6.03 & [68] \\
**27** & Kurardiinol & 5.83 & & & 7.10 & \\ \hline
**28** & Phlorizin & 0.72 & Dihydrochalcone & BACE1 & 2.70 & [69] \\ \hline
**29** & Apigenin & 3.02 & Flavone & BACE1 & 38.50 & [49,50,52,53] \\  & & & GSK-3B & 1.91 & [66] \\  & & & P-IF & NE & [47] \\  & & & AChE & 34.43 & [49] \\ \hline
**30** & Baicalein & 3.27 & Flavone & BACE1 & 69.18 & [70] \\  & & & AChE & 0.61 & [55] \\  & & & P-IF (NO) & 66.40 & [54,71] \\ \hline
**31** & Acacetin & 3.41 & Flavone & BACE1 & 88.50 & [72] \\  & & & AChE & 50.33 & [73] \\ \hline
**32** & Mosolfavone & 3.19 & Flavone & BACE1 & 43.65 & [70] \\ \hline
**33** & Diosmein & 3.10 & Flavone & BACE1 & 43.65 & [70] \\  & & & P-IF & NE & [47] \\ \hline
**34** & Luteolin & 2.53 & Flavone & BACE1 & 13.75 & [74] \\  & & & GSK-3B & 1.51 & [66] \\  & & & P-IF (NO) & 1.74 & [47,54,75,76] \\  & & AChE & 9.27 & [76] \\ \hline
**35** & Norartocarptein & 2.36 & Flavone & BACE1 & 60.60 & [52] \\
**36** & Fitzhovskov-3,4,7- & - & & 2.14 & [70] \\
**37** & _3,4,5,7-_ & 2.43 & & & 1.66 & [70] \\  & Tetramethoxyflavone & 2.43 & & & 1.66 & [70] \\ \hline
**38** & Tangeritin & 3.18 & Flavone & BACE1 & 49.00 & [77] \\  & & & GSK-3B & NA & [66] \\ \hline
**39** & Nobileitin & 2.74 & Flavone & BACE1 & 59.00 & [77] \\  & & GSK-3B & 52.48 & [66] \\ \hline
**40** & Sinnestein & 2.66 & Flavone & BACE1 & 63.00 & [77] \\
**41** & Cirsilineol & 2.54 & & 20.35 & [78] \\
**42** & Isothymusin & 1.98 & & 4.45 & [78] \\ \hline
**43** & Vitexin & \(-\)1.68 & Flavone & BACE1 & 51.07 & [79] \\  & & & AChE & 12.16 & [79] \\ \hline
**44** & Isovitexin & 0.32 & Flavone & BACE1 & NA & [79] \\  & & & GSK-3B & 195.00 & [80] \\  & & & P-IF (NO) & 66.70 & [81] \\  & & AChE & 6.24 & [79] \\ \hline
**45** & 5-O-(\(\beta\)-D- & 0.10 & Flavone & BACE1 & NA & [74] \\  & & & & & \\ \end{tabular}
\end{table} 
Table 2: _Cont._  
\begin{table}
\begin{tabular}{c c c c c c c} \hline \multicolumn{2}{c}{**Flavonoid**} & \multicolumn{2}{c}{**Mechanism of**} & \multicolumn{2}{c}{**IC\({}_{\text{SB}}\)**} \\ N. & **Name** & **LogP\({}^{\text{1}}\)** & **Class** & **Action** & **(uM)** & **Ref.