[27] carried out field measurements of the oxygen concentration inside a typical room in Beijing, and the test results showed that the O\({}_{2}\) concentration inside a densely populated and closed room was generally low. The oxygen supply vent is used to inject a certain concentration of oxygen into closed building spaces, and the oxygen flows out by a gas jet. For jet problems, there are usually three research methods. The first method is to obtain practical empirical relations through experimental data. [PERSON] et al. [28] carried out a small-scale experimental study of CO\({}_{2}\) pipeline leakage, obtaining the peak concentration curve of the monitoring point by power function fitting and determining the safety distance of the production site. [PERSON] et al. [29] studied a combustible refrigerant R32 indoor air-conditioner. The leakage diffusion characteristics were experimentally studied. [PERSON] et al. [30] proposed a method for calculating the stable pressure of small hole leakage by constructing a small hole leakage experimental system for a liquid phase pipeline, which effectively solved the pressure solution problem in the classic calculation formula. The second method is to theoretically analyze the Gaussian distribution of the cross-sectional velocity of the jet [31; 32]. The third method is Computational Fluid Dynamics (CFD) numerical simulation. With the continuous development of computer technology, the CFD method has been adopted by more and more researchers. [PERSON] et al. [33] used different turbulence models to study the flow characteristics of circular jets based on fluent and considered that the standard model could obtain reasonable results. [PERSON] et al. [34] studied the hydrogen leakage process based on CFD simulation, and the results accurately predicted that the diffusion and the law of motion is suitable for emergency treatment. [PERSON] et al. [35] studied the heat transfer characteristics of impinging jets based on numerical simulation. [PERSON] et al. [36] investigated rarefication effects on jet impingement loads at an inclined plate surface, with the jet firing from a planar or round nozzle. The simulation results were compared with recently developed jet impingement flow formulas at the collisionless flow limits. [PERSON] et al. [37] employed an improved one-dimensional diesel spray model to analyze the potential of varying injection rate shapes to lower the pollutant emissions of diesel engines and find the optimized injection strategy. The most effective way to improve the IAQ of traditional closed air-conditioned rooms is to introduce fresh air. But the energy used to process the fresh air during the air-conditioning process accounts for approximately 25% to 30% of the total building energy consumption, and 40% [38] for hotels and office buildings. Therefore, it is particularly important to study the alternative or supplementary schemes of closed air-conditioned room ventilation to improve IAQ in closed air-conditioned rooms. In order to effectively improve the micro-hypoxia environment to meet people's physiological needs and improve work efficiency, local oxygen supply can be provided to closed air-conditioned rooms. This method achieves the dual effects of improving indoor air quality and reducing energy consumption by eliminating micro-hypoxia and reducing fresh air supply. Therefore, based on experiments and CFD numerical simulations, this paper studies the number of oxygen supply vents, the diameter of the oxygen supply vents, the oxygen supply flow rate, the oxygen supply method, and the different air flow organization forms on the oxygen enrichment of a closed air-conditioned room. This article has reference significance for establishing oxygen-enriched safety standards, increasing the amount of fresh air in air-conditioned rooms, and reducing air-conditioning energy consumption.