# Analytical Methods for Exploring Nutraceuticalticals Based on Phenolic Acids and Polypphenols
## 3 Nutraceuticalials from Plant Extracts  
A type of trendy nutraceuticaltical and dietary supplement consists of mixtures of fruit and medicinal plant extracts such as American cranberry and other red and blackberries, turmeric, grapevine, and green tea, with exceptional detoxifying, antiaging, and antioxidant features [32]. American cranberry (_Vaccinium macroxarbon_) is rich in a wide variety of phytochemicals such as saccharides, carotenoids, phenolic acids, and flavonoids [33; 34]. Fresh berries, raisins, and powdered extracts have been used as natural remedies to treat inflammatory and microbial processes. Other properties have also been recognized, including antineoplastic, cardioprotective, or antidegenerative activities [35; 36]. Regarding antimicrobial issues, A-type PACs are the main compounds to be used for the prophylaxis and treatment of urinary tract infections (UTIs). The bioactivity of these species is attributed to their planar structure, which may create a protecting barrier on the urinary tract walls, thus avoiding the adhesion of bacteria [9]. Cranberry extracts are sometimes combined with other medicinal plants such as _Salvia officinalis_, _Urtica urens_, or _Solidago virgaurea_ that provide additional anti-inflammatory and diuretic properties to facilitate the excretion of urine. Another group of nutraceuticalials is focused on products to reduce weight and control obesity [37]. For this purpose, raspberry (_Rubus ideas_) and green tea (_Camelia sinensis_) extracts have been widely used, often combined in the same pharmaceutical form in slimming treatments [38; 39]. Raspberry contains phenolic ketones (e.g., 4-phenylbutan-2-one) that activate the fat metabolism, while green tea is rich in caffeine and epigallocatechin with fat-burning properties. Adjuvant plant extracts with diuretic activity are sometimes included in the composition of this type of product to reinforce the feeling of weight reduction. Preparations based on grape (_Vitis vinifera_) extracts are highly rich in phenolic acids, flavonoids, and stilbenes. Their high antioxidant power is undeniable, thus making grape extracts very healthy [40]. Grapevine is another product derived from _Vitis vinifera_ rich in resveratrol and many other polyphenols, such as rutinosides, with cardioprotective and anti-inflammatory properties to be used in venous insufficiency [41]. Nutraceuticalials made with artichoke (_Cynara scolymus_) possess hypolipidemic, detox, and hepatotoxicity indications. Artichoke extracts contain high amounts of phenolic acids, sesquiterpene lactones, and flavonoids as the principal bioactive compounds [42; 43]. Soya (_Glycine max_), as well as other members of Fabaceae, has been used traditionally in multiple nutraceuticaltical products. The high content in polyphenols provides antioxidant,antimicrobial, and hypolipidemic activity. However, its estrogenic property is probably the most remarkable attribute [20; 21]. Hence, soya-based capsules containing purified extracts of isoflavenes are widely used to treat menopausal symptoms. Turmeric (_Curcuna longa_) belongs to the ginger family, used for centuries as a remedy in traditional Asian pharmacy, as well as a valuable condiment in cuisine. Turmeric extracts or powders of dry rhizome are appreciated due to their antioxidant and anti-inflammatory activities. Turmeric is sometimes combined with other species such as ginger, garlic, and cinnamon for both nutraceutical and culinary purposes. Curcumin and related curcuminoids are the main bioactive compounds of turmeric [7]. Finally, a more diverse group of samples commercialized under detoxifying attributes has also been studied, consisting of mixtures of fruit extracts (_Vaccinium corymbosum_, _Fragaria vesca_, _Vaccinium macroxporom_, _Rubus ideaus_, _Ribes nigrum_, _Vaccinium myrillus_, _Ruscus aculeatus_, and _Punica granatum_) and some medicinal plants (e.g., _Aesculus hipprocastanum_ and _Hamamelis virginiana_).