## 2 Materials and Methods
### NMR Experiment  
One-dimensional \({}^{1}\)H NOESY NMR and \({}^{1}\)H NMR spectra were recorded through a Bruker Avance 400 MHz spectrometer equipped with a 5 mm inverse probe and with an autosampler (Bruker, Billerica, MA, USA). The following acquisition parameters were used to record \({}^{1}\)H NOESY NMR: pulse program = noesygppr1d; size of fid (TD) = 64 K; spectral width (SW) = 20 ppm; transmitter offset = 4.70 ppm; 90\({}^{\circ}\) hard pulse (p1) = 8.16 us; power level for pre-saturation (pl9) = 62.80 dB; dummy scans (ds) = 4; number of scans (ns) = 32; acquisition time = 4.09 s; mixing time (d8) = 0.01 s; recycle delay (d1) = 3 s. The following acquisition parameters were used to record \({}^{1}\)H NMR: pulse program = zg; size of fid (TD) = 64 K; spectral width (SW) = 20 ppm; transmitter offset = 5.00 ppm; 90\({}^{\circ}\) hard pulse (p1) = 8.16 us; power level (pl1) = 1.00 dB; dummy scans (ds) = 0; number of scans (ns) = 128; acquisition time = 4.08 s; recycle delay (d1) = 10.00 s. Bidimensional spectra (TOCSY, and COSY) were acquired with 4096 and 256 data points. The following acquisition parameters were used to record COSY on the aqueous extracts: pulse program = cosygpprqf; size of fid (TD) = 4 K; spectral width (SW) = 15 ppm; transmitter offset = 4.70 ppm; 90\({}^{\circ}\) hard pulse (p1) = 8.16 us; power level for pre-saturation (pl9) = 70.00 dB; dummy scans (ds) = 4; number of scans (ns) = 32; acquisition time = 0.34 s; recycle delay (d1) = 9 s; gradient pulse (p16) = 1.00 ms. The following acquisition parameters were used to record COSY on the DMSO-\(d_{6}\) extracts: pulse program = cosygpqf; size of fid (TD) = 2 K; spectral width (SW) = 15 ppm; transmitter offset = 4.70 ppm; 90\({}^{\circ}\) hard pulse (p1) = 8.16 us; dummy scans (ds) = 4; number of scans (ns) = 16; acquisition time = 0.18 s; recycle delay (d1) = 6 s; gradient pulse (p16) = 1.00 ms. The following acquisition parameters were used to record TOCSY on the aqueous extracts: pulse program = mlevphpr; size of fid (TD) = 4 K; spectral width (SW) = 20 ppm; transmitter offset = 4.70 ppm; 90\({}^{\circ}\) hard pulse (p1) = 8.16 us; power level for pre-saturation (pl9) = 62.80 dB; dummy scans (ds) = 4; number of scans (ns) = 32; acquisition time = 0.26 s; recycle delay (d1) = 7 s; spin lock (d9) = 40.00 ms. The following acquisition parameters were used to record TOCSY on the DMSO-\(d_{\phi}\) extracts: pulse program = mlevph; size of fid (TD) = 4 K; spectral width (SW) = 15 ppm; transmitter offset = 4.70 ppm; 90\({}^{\circ}\) hard pulse (p1) = 8.16 us; dummy scans (ds) = 4; number of scans (ns) = 8; acquisition time = 0.26 s; recycle delay (d1) = 2 s; spin lock (d9) = 75.00 ms.  
Each spectrum was acquired using TOPSPIN 2.1 software (Bruker BioSpin GmbH, Rheinstetten, Germany) under an automatic process that lasted ca. 15 min and encompassed sample loading, temperature stabilization for 5 min, tuning, matching, shimming, and 90\({}^{\circ}\) pulse calibration.  
NMR raw data (Free Induction Decays, FIDs) were processed using the software MestReNova 11.0 (Mestrelab Research SL, Santiago de Compostela, Spain). The FIDs were zero-filled to 128 K number of points and then underwent Fourier transformation by applying an exponential multiplication function with a line broadening of 0.1 Hz. Phase and baseline were automatically corrected, and the TSP singlet signal set at \(\delta\) = 0.00 ppm was used as a chemical shift reference.