Meshes previously used in pelvic floor dysfunction were originally designed for hernia repair, matching the mechanical properties of the abdominal wall, but failed to meet the specific requirements for pelvic support, resulting in a high complication rate [11; 12; 13]. Exploring novel materials and manufacturing techniques is essential to improving women's quality of life. The use of rapid prototyping in additive manufacturing (AM) and 3D printing technology has led to the development of customized medical devices [14]. Previous research has highlighted significant advancements in integrating biomaterials, biopolymers, and additive manufacturing, demonstrating their potential to develop dynamic, self-transforming objects that promote sustainable practices [15; 16]. By analyzing the properties of key biomaterials and exploring the applications of \"living\" hydrogels and tissue engineering scaffolds, research emphasizes the need to create materials that fulfill essential biomedical requirements [17]. These findings pave the way for advanced manufacturing techniques that can effectively address the challenges of complex physiological environments, contributing to the future of biomedical applications and processes [18]. More recently, several studies have focused on the development of biodegradable meshes with non-medical-grade polycaprolactone (PCL) for POP repair, using a prototype of melt electrowriting (MEW) [19; 20; 21; 22; 23; 24]. This has also been studied by [PERSON] et al., who found that biodegradable meshes are a potential effective treatment option for POP [25]. MEW is an innovative method that offers the advantages of cost efficiency and high precision in mesh fabrication, producing fine filaments with nano- and microscale diameters to create intricate mesh structures [26; 27; 28]. Similarly, electrohydrodynamic printing (EHDP) has been used to fabricate polycaprolactone/silk fibroin meshes, demonstrating improved mechanical properties, biocompatibility, and biodegradability [29]. Additionally, research into MEW-printed medical-grade PCL scaffolds loaded with platelet-rich plasma (PRP) has shown promising results for soft tissue regeneration in a sheep model [30]. Recent advancements in biodegradable meshes for POP repair emphasize enhancing mechanical properties and biocompatibility. Innovations, such as incorporating nanoparticle additives like calcium zirconium silicate (CZS) into PCL scaffolds, have demonstrated improved tissue integration and mechanical strength [31]. Furthermore, integrating smart materials, including shape memory polymers and stimulus-responsive hydrogels, into 3D printing techniques offers dynamic, biomimetic solutions. These developments in additive manufacturing and biomaterials are transforming regenerative medicine by creating tissue constructs that closely mimic the mechanical behavior of native tissues, offering improved treatment outcomes [32]. Despite these advancements, mesh-related complications in surgeries remain an issue. Thus, developing meshes with specific properties--such as diameter, pore size, medical-grade material, and mechanical characteristics matching pelvic tissue--remains essential for advancing safer, more effective treatment options. The main objective of this study was to adapt a MEW prototype with a pellet extruder and optimize the printing parameters by comparing medical-grade biodegradable PCL polymers in pellet form with non-medical-grade PCL polymers (Figure 1). The goal was to produce meshes with specific characteristics, including defined geometries such as square and diagonal patterns and controlled filament diameter, as well as specific mechanical properties like stress, strain in uniaxial response, and Secant's modulus. The parameters optimized included the temperature, speed, voltage, and tip-collector distance. Mechanical tests were performed to evaluate the performance of the produced meshes and compare them to vaginal tissue and a commercially available mesh.