## 1 Introduction  
The major function of skin is to act as protective barrier between body and environment. Skin injury causes loss of slight or larger skin part, which may cause serious disability and even death. The primary concern of wound treatment is rapid wound repair and prevention from chronic wound (ulcer) [1]. Wound healing is a typical biological process, which consists of three major tasks i.e., inflammatory response, new tissue formation, and, finally, tissue remodeling. Wound healing is influenced by wound microenvironment. Skin-wound microenvironment could majorly classify as interior and exterior. Term \"interior microenvironment\" refers to environment exterior to wound but in direct contact with skin surface, while exterior microenvironment refers to the environment under wound surface and adjacent to the wound region [2]. Interior and exterior environment constitute a number of factors. Some of which have a major impact on wound healing e.g., humidity, temperature, oxygen tension and infection [3]. Clinical researchers also studied the local and systemic factors which may impair wound healing. i.e., local factors including infection, bacteria and patient age--diabetics and other diseases are included in systemic factors [4]. Therefore, continuous monitoring of wound microenvironment for wound management may result in a better response of wound healing. Different wound types hold different features e.g., acute wounds which occurs suddenly, go through all these wound healing phases in a systematic manner, but chronic wounds did not follow normal healing phases, rather they remain in inflammatory phase for long duration [5]. Therefore, acute wound showed high temperature to promote blood flow at wound site while chronic wound temperature is low due to impaired blood supply. In past, before wound healing investigation work done by [PERSON] and [PERSON], it was widely accepted that dry wound environment boosts wound healing. It has now accepted after lots of investigation that moist wound environment necessary to promote new tissues growth. However, moist balance maintenance is very critical issue, as excessive moist can impair wound healing [6]. An important step in wound local care is wound bed preparation. Wound dressing helps to heal wound faster by providing protection, prevention against harmful external bodies and also helpful in provision of moist balance. Two most common wound dressing are gauze-based dressing and second modern dressings, foams, hydrocolloids, hydro fibers, gels and films which based on principle of occlusive wound healing [7]. Discussion of previous studies revealed that lot of factors are correlated with wound healing, where exterior environment is one of them which is most critical one. Consequently, a comprehensive wound care solutions must investigate most prominent exterior environment factors, as shown in Figure 1. i.e., temperature, humidity, smoke in air and air pollutants. These exterior factors can impact wound healing in given manners. * Exterior temperature correlated with skin moisture level, if exterior temperature level is high, human body generates more sweating to maintain body normal temperature, this may cause moisture loss and wound became dry which ultimately result in delay of wound healing. * Exterior humidity level correlated with temperature, high humidity cause disturbs body temperature level and cause more sweating which ultimately effect wound hydration and moisture. Figure 1: Exterior Environment Role in Wound Healing. * Exterior environment smoke effected oxygen intake of body, while all living tissues required oxygen and nutrients to grow well. In case of skin injury tissue damage and they required healthy regeneration during healing. So, skin wound demanded suitable amount of oxygen for healthy recovery. [PERSON] et al.