# Can Semantics Uncover Hidden Relations between Neurodegenerative Diseases and Artistic Behaviors?
###### Abstract  
Semantics play a crucial role in organizing domain knowledge, schematizing it, and modeling it into classes of objects and relationships between them. Knowledge graphs (KGs) use semantic models to integrate and represent different types of data. This study aimed to systematically review related work on the topics of ontologies for neurodegenerative diseases (NDs), ontology-based expert systems for NDs, and the artistic behavior of ND patients. The utilization of ontologies allows for a more comprehensive understanding of the progression and etiology of NDs, the structure and function of the brain, and the artistic expression associated with these diseases. The data collected from ND patients highlights the presence of cases where artistic expression can be linked to the disease. By developing fuzzy ontologies for NDs and incorporating them into expert systems, early detection and monitoring can be supported. Through our systematic review, we identify and discuss open issues and challenges in understanding the relationship between ND patients and their artistic behavior. We also conclude that ontology-based expert systems hold immense potential in uncovering hidden correlations between these two. Further research in this area has the potential to address key research questions and provide deeper insights. neurogenerative disease; fuzzy semantics; artistic behavior; ontologies +
Footnote †: journal: Medical  
network, and limbic system, which likely contributes to artists' ability to create new and innovative works of art [1; 2; 3]. As described by [PERSON] et al. 2022 [5], these brain regions collaborate in the expression of artistic activities such as painting, dance, creative writing, and more. A literature review revealed a connection between NDs and individuals who participate in performing arts. The symptomatology and brain regions involved in art production were previously identified in the literature [6; 7]. Studies [5; 6; 7] discovered a link between NDs and participation in performing arts, with a higher prevalence of musical and artistic abilities among individuals with autism spectrum disorder (ASD) compared to the general population [8]. This is believed to stem from enhanced abilities in perception and attention to detail in individuals with ASD, which are advantageous for tasks related to music and art. Participation in performing arts was found to have therapeutic benefits for individuals with NDs, such as improving social skills and reducing anxiety [9]. However, it is important to note that not all individuals with NDs will have enhanced artistic abilities or benefit from participation in performing arts, as the relationship between NDs and artistic abilities is complex and multifactorial. Advancements in ontology technology provide the capacity to manage and combine various forms of heterogenous big data, but a scale of aesthetic expression or style identification cannot be established through arts. Hence, research into the connection between NDs and artistic abilities requires the adoption of fuzzy concept research, as the mechanisms involved in NDs are complex and often uncertain. Studies examined artistic production in individuals before and after the manifestation of NDs and discovered alterations in style as well as new artistic talents in specific cases. Our hypothesis is that there is a structural and functional overlap between NDs and aesthetic expression. This hypothesis is supported by studies in neuroscience, which found similarities in the brain regions and cognitive processes activated during both NDs and artistic tasks [2; 3; 4; 5]. Structural overlap refers to the presence of similar brain regions that are activated during both NDs and artistic tasks, such as the amygdala, which is involved in processing emotions and has increased gray matter volume in individuals with ASD [7; 8; 9].