# The Link Between Physical Function, \(\beta\)-Amyloid, and Cognitive Aging in Women
## 3 Results
### Mediation Analysis  
To examine whether the association between baseline FC and longitudinal cognitive function was potentially mediated by the baseline A\(\beta\) burden, a mediation analysis was performed controlling for age, years of education, ApoE4 genotype, and FHS-CVD. The association between the TUG and PACC scores was statistically accounted for by baseline A\(\beta\) burden in 2012 (Figure 2, cognition 2012). However, for cognition in 2014, FC was partially mediated by the baseline A\(\beta\) burden (Figure 2, cognition 2014). In both cases (model 1 and model 2), TUG performance showed an indirect association with cognition, such that faster TUG results were associated with lower A\(\beta\) deposition.  
No significant associations were found between the baseline TUG and PACC scores in 2019 (Figure 2, cognition 2019).  
\begin{table}
\begin{tabular}{c c c c c c} \hline \hline  & \multicolumn{5}{c}{**Dependent Variable: PACC 2012**} \\ \hline  & **F** & **df** & \(p\) & **R\({}^{2}\)** & **Adjusted R\({}^{2}\)** \\ \hline
**Final Model** & 14.290 & 3,85 & \(<\)0.001 & 0.335 & 0.312 \\ \hline
**Independent Variables** & **B** & **SE** & \(\beta\) & **t** & **Sig.** \\ \hline
**Baseline SUVR \({}^{*}\)** & \(-\)2.064 & 0.461 & \(-\)0.403 & \(-\)4.481 & \(<\)0.001 \\
**Education (years) \({}^{*}\)** & \(0.081\) & 0.025 & 0.286 & 3.200 & 0.002 \\
**Age (years) \({}^{*}\)** & \(-\)0.077 & 0.036 & \(-\)0.193 & \(-\)2.161 & 0.033 \\ \hline  & \multicolumn{5}{c}{**Dependent Variable: PACC 2014**} \\ \hline  & **F** & **df** & \(p\) & **R\({}^{2}\)** & **Adjusted R\({}^{2}\)** \\ \hline
**Final Model** & 22.117 & 3,84 & \(<\)0.001 & 0.441 & 0.421 \\ \hline
**Independent Variables** & **B** & **SE** & \(\beta\) & **t** & **Sig.** \\ \hline
**Baseline SUVR \({}^{*}\)** & \(-\)2.563 & 0.474 & \(-\)0.465 & \(-\)5.407 & \(<\)0.001 \\
**Education (years) \({}^{*}\)** & \(0.097\) & 0.026 & 0.318 & 3.698 & \(<\)0.001 \\
**Baseline TUG (seconds) \({}^{*}\)** & \(-\)0.200 & 0.070 & \(-\)0.251 & \(-\)2.859 & 0.005 \\ \hline  & \multicolumn{5}{c}{**Dependent Variable: PACC 2019**} \\ \hline  & **F** & **df** & \(p\) & **R\({}^{2}\)** & **Adjusted R\({}^{2}\)** \\ \hline
**Final Model** & 15.577 & 3,57 & \(<\)0.001 & 0.450 & 0.422 \\ \hline
**Independent Variables** & **B** & **SE** & \(\beta\) & **t** & **Sig.** \\ \hline
**Baseline SUVR \({}^{*}\)** & \(-\)4.505 & 0.813 & \(-\)0.550 & \(-\)5.544 & \(<\)0.001 \\
**Education (years) \({}^{*}\)** & 0.090 & 0.035 & 0.257 & 2.576 & 0.013 \\
**FHS-CVD (index) \({}^{*}\)** & \(-\)2.722 & 1.122 & \(-\)0.239 & \(-\)2.427 & 0.018 \\ \hline \hline \end{tabular} Abbreviations: ApoE, apolipoprotein E; FHS-CVD, Framingham Heart Study cardiovascular disease risk index; PACC, Preclinical Alzheimer Cognitive Composite; SUVR, Standardized Uptake Value Ratio; and TUG, timed up and go test. All analyses were adjusted by age, ApoE4 genotype, education, and FHS-CVD. Rows are marked with an asterisk to indicate results that survived correction for multiple comparisons using the Benjamini–Hochberg procedure.  
\end{table}
Table 3: Stepwise multiple linear regressions for associations of cognitive function (PACC) over time with baseline brain amyloid burden (SUVR) and baseline functional capacity (TUG).