Furthermore, studies conducted over the last two decades indicate a strong correlation between the impaired healing of chronic wounds and low levels of antioxidants with a low molecular weight [14], suggesting that a supplementation of these compounds could enhance and ameliorate the regeneration process [15]. This hypothesis was confirmed by several specific experiments conducted on animal wound models; for instance, [PERSON] et al. found that the administration of \(\alpha\)-tocopherol (VitE) led to the drastic lowering of lipid peroxydes in diabetic mice, resulting in a significant enhancement of the wound healing process [16]. Clinically, the standard procedures for the management and treatment of chronic ulcers are represented by the periodical debridement of necrotic tissue and the surgical drainage of abscesses, the management of infections (antibiotic therapies), negative pressure sessions, and the application of medicated dressings [17]. The latter are more and more investigated and employed as adjuvant treatments since novel materials are continuously being developed as are the manufacturing techniques used to manipulate them. Nowadays, several alternatives are widely available on the market, ranging from highly absorbent patches to moisturizing ones, produced by exploiting both naturally occurring or synthetic materials. Many of the aforementioned products are loaded with silver or other antimicrobial substances for the control of ongoing infections [18]. Nevertheless, these active ingredients often result in high toxicity and might delay cell proliferation and differentiation from the wound bed [19]. Among medicated dressings, active ones are conceived to promote healing by providing a biocompatible microenvironment that is able to host cell proliferation. The fundamental element of this approach is the presence of an ECM biomimetic scaffold: for this reason, the choice of the material is of primary importance in terms of physical form, hydration, mechanical strength, and porosity as well as shaping/structuration. Taking naturally derived polymers into account [20], chitosan is considered to be unique because of its combination of biological properties, such as hemostatic action, biocompatibility [21], and wide spectrum antimicrobial activity [22]. Furthermore, this cationic polysaccharide, which is composed of repeated sequences of acetyl-glucosamine and glucosamine, has a great chemical similarity with the glycosaminoglycans present in the ECM, prompting its use as a scaffolding material for tissue regeneration [23]. In the literature, other works have described the useful association of chitosan and vitamin E in wound dressings [24; 25; 26], but preparation methods include the use of other polymers and organic crosslinkers or gamma radiation to induce chitosan gelation, which could leave potentially toxic residues. In this work, a freeze-deposition 3D printing method is proposed, offering the chance to avoid toxic solvents while providing a controlled porosity of the hydrogel. The three-dimensionality of chitosan scaffolds was recently investigated by [PERSON] et al. [27] in terms of wound healing enhancement, exploiting it for their production of a freeze-deposition additive manufacturing system developed to obtain reproducible, micro-structured, biocompatible chitosan hydrogels, as previously reported by [PERSON] et al. [28]. The use of three-dimensional printing provides the chance to design more complex devices in terms of geometry and control of drug release towards the target of tailored personalized medicine with respect to traditional manufacturing processes [29; 30]. Certain 3D chitosan constructs have also favored human fibroblast/keratinocyte adhesion and three-dimensional growth in vitro, spurring the cell proliferation rate compared to bi-dimensional sheets of the same material. Additionally, these patch prototypes implanted in vivo on a diabetic model in Wistar rats led to faster and improved wound healing [27].