## 4 Discussion  
The conclusions of this review underscore the potential of digital health interventions in addressing psychological factors associated with asthma, particularly in children and adolescents. The studies included demonstrated that eHealth interventions, mixed reality tools, mHealth technology-enhanced nurse-guided interventions, and smartphone applications integrating EMA and Bluetooth-enabled sensors for asthma inhalers can significantly enhance symptom self-management, quality of life, and mental health outcomes in this demographic [32, 35]. The systematic review by [PERSON] et al. [45] sheds light on the potential benefits of eHealth interventions in addressing psychological sequelae associated with chronic medical conditions in pediatric populations. Their findings suggest that tailored eHealth interventions, encompassing self-management education and interactive asthma monitoring, have the potential to improve disease management and enhance the quality of life in children with persistent asthma. Moreover, the authors advocate for the integration of evidence-based theoretical frameworks, such as cognitive behavioral therapy or problem-solving therapy, into future eHealth interventions to meet the specific needs of children with medical conditions. In contrast, the systematic review conducted by [PERSON] et al. [46] presents a more nuanced perspective on the efficacy of eHealth interventions for anxiety and depression in children and adolescents with long-term physical conditions, including asthma. Despite incorporating five trials involving various interventions, the authors found very low-quality evidence regarding the superiority and acceptability of eHealth interventions compared to standard treatments. This uncertainty underscores the need for further research to develop and evaluate effective and acceptable e-health interventions tailored to the unique challenges faced by children and adolescents with chronic medical conditions. However, while the findings of these studies highlight the potential of eHealth interventions in augmenting disease management and addressing psychological distress in pediatric populations with asthma, it is crucial to note that the domain of digital health interventions for the treatment of anxiety or depression in conjunction with long-term physical conditions, including asthma, remains limited. Additional research is required to ascertain the effectiveness and feasibility of these interventions across diverse populations and settings [35]. Tailored interventions that cater to the specific needs and preferences of patients with asthma and associated psychological factors are vital for ensuring sustained and equitable utilization of these technologies [35]. Future studies should concentrate on enhancing methodological rigor, generalizability, and long-term outcomes, as well as addressing concerns about accessibility, privacy, and data security. The development of personalized interventions and the integration of digital health technologies into routine clinical care holds the potential to affect a significant difference in public health for individuals living with chronic conditions, including asthma. In addition, another critical aspect to consider when discussing digital health interventions is that, unfortunately, not everyone has equal access to the use of digital health technologies among different demographic groups based on socioeconomic status, geographic location, education level, and age on the adoption and effectiveness of eHealth and mHealth interventions for asthma management [47]. It is clear that individuals from underserved communities or those with limited access to technology may face significant barriers to benefiting from digital health interventions. Factors such as lack of Internet connectivity, low digital literacy, and limited access to smartphones or computers can hinder their ability to use these technologies effectively. Addressing the digital divide is critical to ensuring equitable access to health resources and interventions.