# A Genomic Survey of Signalling in the Myxococcaceae
## 3 Results
### Different Families of Regulators Exhibit Distinct Patterns of Conservation
\begin{tabular}{c c c c c c c c c c c c c c c c c c c c} \hline \hline
**Protein Class** & **P** & **F** & **RR** & **RR** & **RR** & **RR** & **RR** & **RR** & **RR** & **RR** & **RR** & **RR** & **RR** & **RR** & **RR** & **RR** & **TR** & **TR** & **TR** & **TR** & **TR** \\ \hline
**Protein Family** & **HikKa** & **Hpt** & **CheV** & **CJC-C** & **LyITR** & **GompR** & **Pra** & **Tori** & **VieB** & **Xne** & **MerR** & **Fur** & **HrcA** & **NrdR** & **PucR** & **Rak** \\ \hline \hline \(\alpha\)_depressions_ AR000A & 3 & 1 & 2 & 5 & 9 & 1 & & 1 & 6 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_countfresh_ CA010 & 3 & 1 & 2 & 8 & 12 & 1 & & 1 & 6 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_countfresh_ D8299 & 2 & 1 & 2 & 5 & 9 & 1 & & 1 & 7 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_countfresh_ AR00A & 3 & 1 & 2 & 5 & 11 & 1 & 1 & 8 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_countfresh_ AR027A & 2 & 1 & 2 & 8 & 1 & 1 & 5 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_countfresh_ CA011 & 4 & 1 & 2 & 7 & 9 & 1 & & 1 & 5 & 2 & 1 & 1 & 1 \\ \hline \(\alpha\)_countfresh_ CA013B & 5 & 1 & 2 & 8 & 11 & 1 & 1 & 7 & 2 & 1 & 1 & 1 \\ \hline \(\alpha\)_countfresh_ CA040B & 3 & 1 & 2 & 4 & 10 & 1 & 1 & 8 & 2 & 1 & 1 & 1 \\ \hline \(\alpha\)_countfresh_ CA054A & 3 & 1 & 2 & 7 & 10 & 1 & 1 & 6 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_countfresh_ D81466 & 2 & 1 & 2 & 6 & 10 & 1 & 1 & 6 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_census_ AR004 & 3 & 1 & 2 & 7 & 13 & 1 & 1 & 6 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_census_ AR016 & 8 & 1 & 2 & 7 & 13 & 1 & 1 & 6 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_census_ AR018 & 3 & 1 & 1 & 2 & 6 & 11 & 1 & 1 & 5 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_census_ AR030 & 3 & 1 & 1 & 2 & 6 & 11 & 1 & 1 & 5 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_census_ AR031 & 3 & 1 & 2 & 7 & 13 & 1 & 1 & 6 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_census_ AR032C & 3 & 1 & 2 & 7 & 13 & 1 & 1 & 7 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_census_ AR038B & 3 & 1 & 2 & 8 & 12 & 1 & 1 & 6 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_census_ AR051 & 5 & 1 & 2 & 7 & 13 & 1 & 1 & 6 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_census_ CA011A & 2 & 1 & 1 & 2 & 5 & 11 & 1 & 1 & 6 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_census_ CA048 & 3 & 1 & 2 & 6 & 11 & 1 & 1 & 6 & 2 & 1 & 1 & 1 & 1 \\ \hline \end{tabular}   
\begin{tabular}{c c c c c c c c c c c c c c c c} \hline \hline
**Protein Class** & **P** & **FR** & **RR** & **RR** & **RR** & **RR** & **RR** & **RR** & **RR** & **RR** & **RR** & **TR** & **TR** & **TR** & **TR** & **TR** \\ \hline
**Protein Family** & **HikKa** & **Hpt** & **CheV** & **CJC-C** & **LyITR** & **GompR** & **Pra** & **Tori** & **VieB** & **Xne** & **MerR** & **Fur** & **HrcA** & **NrdR** & **PucR** & **Rak** \\ \hline \hline \(\alpha\)_depressions_ AR000A & 3 & 1 & 2 & 5 & 9 & 1 & & 1 & 6 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_countfresh_ CA010 & 3 & 1 & 2 & 8 & 12 & 1 & & 1 & 6 & 2 & 1 & 1 & 1 & 1 \\ \hline \(\alpha\)_countfresh_ D8299 & 2 & 1 & 2 & 5 & 9 Some protein families, for example Hpt proteins, are present in small numbers, in some but not all members of a group of genomes (a single Hpt protein each is found in the genomes of just _P. fallax_ and three strains of _C. exigius_). Such proteins are not components of the core genome and are most likely to have been acquired recently by horizontal gene transfer. Other examples include the TrxB response regulator, which is found in four of the eleven _Myxococcus/Pyxidicoccus_ spp. genomes, and HisKA phosphotransfer proteins, which, when present, are found in small and highly variable numbers. Some other protein families are found in small numbers in each genome (or each genome within a group), but at a constant number. These proteins are therefore part of the core genome, and illustrative examples include CheV, HrcA, NrdR, Rok and Xre (one in each genome), VieB (one in each _Myxococcus/Pyxidicoccus_ genome, but absent from _Corallococcus_ genomes) and PucR (one in each _C. exigius_ genome, but only present sporadically in _Myxococcus_ spp. and _Corallococcus_ spp.