###### Abstract
The relatively low toxicity of AuNPs, compared to other metallic nanoparticles such as copper (Cu) or radon (Rn), opens up many opportunities for medical applications. These applications include diagnostics, therapeutics, biosensors, targeted delivery of anticancer drugs, or immunoassay. Gold nanoparticles have been scientifically confirmed to play a potential role in anti-cancer therapies such as chemo-radiotherapy, thermo-chemotherapy, thermo-radiotherapy, thermo-chemotherapy, and gene therapy [14]. The phenomenon of chemoresistance in neoplastic cells manifests itself over time due to chronic exposure to pharmacological agents. Gold nanoparticles can enhance the accumulation of drugs inside cells. When doxorubicin (DOX) is attached to gold nanoparticles, it increases the concentration of the drug inside the cells, leading to improved effectiveness in killing the cancer cells compared to using doxorubicin alone (not bound to gold nanoparticles) [15]. The optical properties of AuNPs make them useful in highly sensitive sensors and imaging-based therapeutic modalities for oncological treatments and other medical conditions [6]. AuNPs also show promise as carriers of antimicrobial drugs, which is especially important given the increasing resistance of bacteria to antibiotics. They make it possible to limit the concentrations of antibiotics used by reducing their potential toxicity. It is believed that AuNPs can increase the efficacy of antibiotics and other chemotherapeutic agents or even antifungal drugs [16]. Interesting data were obtained for vancomycin [17] and gentamicin or floorouracil [18; 19], as well as chloramphenicol [20]. AgNPs can also be used for their antifungal potential, which can be further enhanced with antifungal drugs, including azoles [21]. Azoles represent a class of heterocyclic compounds with a five-membered aromatic ring that includes at least one nitrogen atom as a heteroatom. Compounds like linezolid, cefixime, metronidazolezole, and ceforanide have antimicrobial activity and are used in therapeutic applications. Micronazole, fluconazoleide, and itraconazole (ITZ) possess antifungal activity, and nitazoxanide, ribavirin, and ritonavir have antiviral activity [22]. ITZ is a synthetic azole antifungal drug that can be used for the long-term treatment of chronic fungal infections due to its low toxicity. It works by binding to the cytochrome P-450 of the fungus, inhibiting the enzyme lanosterol, and blocking the demethylation of lanosterol to ergosterol, a key component of the fungal cell membrane. This leads to an increase in the permeability of the cell membrane, the disappearance of its protective function, the inhibition of growth, and consequently, the death of the fungal cell. It has a broad spectrum of activity against many fungal species, including _Candidia_, _Aspergillus_, _Cryptococcus_, _Trichophthora_, _Microsporum_, _Epiderruption_, and _Malassezia_[22]. However, the poor solubility of ITZ in water presents a significant challenge in developing topical formulations. It has been suggested that adding hydroxypropyl-beta-cyclodextrintrim may enhance solubility [19], or using an amorphous form of ITZ [23] may be a valuable approach. Nevertheless, the safety profile and tolerability of the active substance (ITZ) indicate that the potential development of a topical formulation may be advantageous [24]. Furthermore, a report by [PERSON] et al. suggests that gold nanoparticles can serve as carriers to facilitate the targeted delivery of ITZ, increasing its concentration at the site of infection and reducing systemic exposure [25]. AuNPs can be functionalized with a variety of ligands to target specific fungal cells, thereby enhancing the specificity and efficacy of antifungal treatment [26]. The utilization of AuNPs may facilitate the penetration of ITZ into fungal biofilms by disrupting its structure [27]. The potential efficacy of the system may be attributed to the generation of reactive oxygen species (ROS), which can damage fungal cell membranes and ultimately result in cell death [26].