## 4 Conclusions
\begin{table}
\begin{tabular}{l|l|l|l} \hline \hline
**Transition** & **Biological Meaning** & **Transition** & **Biological Meaning** \\ \hline \(t_{0}\) & Hepatic lipase (LIPC) activation & \(t_{61}\) & high inorganic pyrophosphate (PPI) \\  & & OH phosphorylation \\ \hline \(t_{1}\) & endocytosis via RME & \(t_{62}\) & processes increasing inorganic pyrophosphate \\  & & (PPI) 1 activity \\ \hline \(t_{2}\) & binding LDL and LDL-R & \(t_{63}\) & conversion from CE found in HDL into free \\  & & cholesterol pool \\ \hline \(t_{3}\) & LDL-R expression on cell membrane & \(t_{64}\) & hydrolase of cholesterol esters activation \\ \hline \(t_{4}\) & increasing activity by SREBP2 & \(t_{65}\) & remaining cholesterol removed by fecal sterols \\ \hline \(t_{5}\) & LKB1 activation & \(t_{66}\) & reabsorption in the intestine and return to the liver \\ \hline \(t_{6}\) & processes increasing intracellular calcium & \(t_{67}\) & apical sodium-dependent bile acid transporter \\  & & (ASBT) activation \\ \hline \(t_{7}\) & conversion into LDL & \(t_{68}\) & HSL activation \\ \hline \(t_{8}\) & receptor being returned stimulated by lower pH & \(t_{69}\) & hydrodylation of stored TAG \\ \hline \(t_{9}\) & acetyl CoA synthesis from glucose in the liver & \(t_{70}\) & free fatty acids (FFA) pool in adipose tissue increases \\ \hline \(t_{10}\) & processes lowering free cholesterol pool in the & \(t_{71}\) & LCAT activation in serum \\  & intestine and the peripheral tissues & \(t_{71}\) & LCAT activation in serum \\ \hline \(t_{11}\) & AMP-activated protein kinase & \(t_{72}\) & processes catalyzed by ACAT \\  & AMPK phosphorylation & \(t_{72}\) & \\ \hline \(t_{12}\) & processes decreasing phosphoprotein phosphatase & \(t_{73}\) & steroid synthesis \\ \hline \(t_{13}\) & conversion VLDL into IDL, TAG hydrolysis & \(t_{74}\) & TAG storage in adipocytes \\ \hline \(t_{14}\) & CE hydrolysis & \(t_{75}\) & ACAT activation in the intestine \\ \hline \(t_{15}\) & lysosomal lipase activation & \(t_{76}\) & diet and hypertension \\ \hline \(t_{16}\) & carboxylation catalysed by acetyl CoA & \(t_{77}\) & efflux of cholesterol to ApoA-1 and ApoE \\  & carboxylase (ACC) & \(t_{77}\) & catalysed by ABCA1 \\ \hline \(t_{17}\) & decarboxylation & \(t_{78}\) & HDL synthesis in the Liver \\  & & (AMPK-OH) inactive & \(t_{79}\) & nascent CM synthesis in enterocytes \\ \hline \(t_{19}\) & pancreatic synthesis & \(t_{80}\) & HDL secreted by enterocytes and by the liver \\ \hline \(t_{20}\) & free cholesterol effluxes endosome & \(t_{81}\) & cholesterol transport from the lumen to \\  & & the intestinum \\ \hline \(t_{21}\) & reaction catalysed by thiolase & \(t_{82}\) & NPC11 activation \\ \hline \(t_{22}\) & mexulonate synthesis & \(t_{83}\) & processes lowering cholesterol \\ \hline \(t_{23}\) & malonyl CoA decarboxylase (MCD) activation & \(t_{84}\) & expression remnant CE receptors in the liver when \\  & & the intestinal pool is high \\ \hline \(t_{24}\) & dephosphorylation by protein phosphatase 2C & \(t_{85}\) & ApoC-2 returned to HDL cholesterol \\ \hline \(t_{25}\) & protein phosphatase activation & \(t_{86}\) & exchanging HDL components in blood \\ \hline \(t_{26}\) & HMG inactivation by phosphorylation & \(t_{87}\) & nascent CM exchange components with HDL \\ \hline \(t_{27}\) & processes decreasing HMGCR & \(t_{88}\) & transport mainly TAG within nascent \\  & phosphatase activity & & chylomicrons from the intestine to the blood \\ \hline \(t_{28}\) & CE transfer from LDL & \(t_{89}\) & conversion cholesterol into CE \\ \hline \(t_{29}\) & thiolase activation & \(t_{90}\) & transport by ABCA1 \\ \hline \(t_{30}\) & acetyl-CoAs conversion & \(t_{91}\) & LPL activation \\ \hline \(t_{31}\) & reaction phosphorylation catalysed by ATP & \(t_{92}\) & FFA absorption in enterocyte \\ \hline \(t_{32}\) & fatty acids (FA) synthesis in the liver & \(t_{93}\) & ABCA1 synthesis \\ \hline \(t_{33}\) & dephosphorylation of ACC and its activation & \(t_{94}\) & cholesterol pool increases in the intestine because \\  & & & of biliary cholesterol \\ \hline \(t_{34}\) & dephosphorylation & \(t_{95}\) & formation of the biliary cholesterol \\ \hline \(t_{35}\) & CE transfer from HDL-2 & \(t_{96}\) & bile acids synthesis \\ \hline \(t_{36}\) & HMG-CoA synthase activation in cytoplasm & \(t_{97}\) & reaction increasing cholesterol pool in the liver \\  & & via RME \\ \hline \(t_{37}\) & reaction forming farnesyl PP & \(t_{98}\) & TG distribution from CM \\ \hline \(t_{38}\) & decreased PKA activation & \(t_{99}\) & binding with glycerol albumins \\ \hline \(t_{39}\) & HMG activation & \(t_{100}\) & ACAT activation in the liver \\ \hline \(t_{40}\) & CETP secretion from the liver & \(t_{101}\) & re-esterification of cholesterol by ACAT in the liver \\ \hline \(t_{41}\) & beta oxidation & \(t_{102}\) & APOB100 synthesis in the liver and secreted \\  & & into circulation \\ \hline \hline \end{tabular}
\end{table}