## 3 Results
### Prediction of plaque Progression
\begin{table}
\begin{tabular}{c c c c c c} \hline \multirow{2}{*}{**Dependent Variable**} & \multirow{2}{*}{**Effect**} & \multicolumn{2}{c}{**Univariate Logistic Regression**} & \multicolumn{2}{c}{**Multivariate Logistic Regression**} \\ \cline{3-6}  & & \multicolumn{2}{c}{**Analysis**} & \multicolumn{2}{c}{**Analysis**} \\ \cline{3-6}  & & **Odds Ratio** & \(p\)**-Value** & **Odds Ratio** & \(p\)**-Value** \\ \hline \multirow{7}{*}{Plaque progression} & Age (years) & 1.028 (1.001 to 1.056) & 0.0401 & 1.067 (1.023 to 1.114) & 0.0026 \\ \cline{2-6}  & Triglycerides (mg/dl) & 1.004 (1.000 to 1.009) & 0.0605 & 1.000 (0.992 to 1.009) & 0.9453 \\ \cline{2-6}  & CE\_16\_1 (\mu\)M & 1.002 (1.000 to 1.004) & 0.0650 & 1.002 (1.000 to 1.005) & 0.0751 \\ \cline{2-6}  & CE\_18\_3 (\mu\)M & 1.011 (1.003 to 1.019) & 0.0095 & 1.004 (0.979 to 1.030) & 0.7523 \\ \cline{2-6}  & CE\_20\_3 (\mu\)M & 1.035 (1.011 to 1.060) & 0.0043 & 1.021 (0.959 to 1.086) & 0.5153 \\ \cline{2-6}  & CE\_20\_4 (\mu\)M & 1.006 (1.000 to 1.013) & 0.0552 & 1.002 (0.982 to 1.023) & 0.8269 \\ \cline{2-6}  & PC\_36\_0 (\mu\)M & 1.044 (0.999 to 1.091) & 0.0534 & 1.025 (0.950 to 1.106) & 0.5219 \\ \cline{2-6}  & TG\_54\_2\_TG\_18\_1 & 1.008 (0.999 to 1.016) & 0.0783 & 1.009 (0.996 to 1.022) & 0.1831 \\ \cline{2-6}  & PS\_38\_5 (\mu\)M & 1.512 (1.006 to 2.275) & 0.0469 & 2.742 (1.116 to 6.734) & 0.0278 \\ \cline{2-6}  & SM\_38\_1 (\mu\)M & 1.017 (0.999 to 1.034) & 0.0581 & 1.032 (0.987 to 1.079) & 0.1717 \\ \cline{2-6}  & SM\_42\_1 (\mu\)M & 1.012 (1.000 to 1.023) & 0.0464 & 1.029 (1.005 to 1.054) & 0.0168 \\ \cline{2-6}  & Baseline lumen area & 1.882 (1.493 to 2.371) & \(<\) 0.0001 & 1.171 (0.776 to 1.767) & 0.4517 \\ \cline{2-6}  & \multirow{2}{*}{Baseline plaque area (mm\({}^{2}\))} & \multirow{2}{*}{2.613 (2.140 to 3.191)} & \multirow{2}{*}{\(<\) 0.0001} & \multirow{2}{*}{1.626 (1.117 to 2.366)} & \multirow{2}{*}{0.0112} \\  & (mm\({}^{2}\)) & & & & \\ \cline{2-6}  & Baseline plaque & \multirow{2}{*}{1.066 (1.053 to 1.079)} & \multirow{2}{*}{\(<\) 0.0001} & \multirow{2}{*}{1.066 (1.044 to 1.087)} & \multirow{2}{*}{\(<\)0.0001} \\  & burden & & & & \\ \cline{2-6}  & SmartFFR & 5.671 (1.751 to 18.370) & 0.0038 & 1.043 (0.773 to 1.407) & 0.7814 \\ \cline{2-6}  & Minimum ESS (Pa) & 1.194 (1.081 to 1.319) & 0.0005 & 1.069 (0.737 to 1.550) & 0.7239 \\ \cline{2-6}  & Maximum LDL & \multirow{2}{*}{1.164 (0.992 to 1.367)} & \multirow{2}{*}{0.0634} & \multirow{2}{*}{1.094 (0.170 to 7.038)} & \multirow{2}{*}{0.9245} \\  & concentration & & & & \\ \hline Hypertension & 1.570 (1.017 to 2.423) & 0.0418 & 1.599 (1.025 to 2.495) & 0.0385 \\ \cline{2-6}  & Age (years) & 1.026 (1.001 to 1.052) & 0.0436 & 1.001 (0.965 to 1.038) & 0.9622 \\ \cline{2-6}  & Diabetes & 2.025 (1.083 to 3.788) & 0.0272 & 1.085 (0.514 to 2.289) & 0.8305 \\ \cline{2-6}  & Hypertension & 1.644 (1.029 to 2.626) & 0.0377 & 3.116 (1.595 to 6.089) & 0.0009 \\ \cline{2-6}  & Triglycerides (mg/dl) & 1.004 (1.000 to 1.007) & 0.0634 & 1.003 (0.996 to 1.010) & 0.3980 \\ \cline{2-6}  & Cer\_d18\_1\_16\_0 (\mu\)M & 1.110 (0.985 to 1.250) & 0.0859 & 1.192 (1.017 to 1.397) & 0.0297 \\ \cline{2-6}  & CE\_16\_0 (\mu\)M & 1.001 (1.000 to 1.002) & 0.0039 & 1.001 (0.998 to 1.004) & 0.3945 \\ \cline{2-6}  & CE\_16\_1 (\mu\)M & 1.002 (1.000 to 1.003) & 0.0077 & 1.000 (0.998 to 1.003) & 0.7316 \\ \cline{2-6}  & CE\_18\_1 (\mu\)M & 1.001 (1.000 to 1.001) & 0.0131 & 1.000 (0.999 to 1.002) & 0.5703 \\ \cline{2-6}  & SM\_36\_2 (\mu\)M & 1.040 (1.000 to 1.081) & 0.0513 & 1.148 (0.999 to 1.318) & 0.0511 \\ \cline{2-6}  & SM\_38\_2 (\mu\)M & 1.080 (1.007 to 1.158) & 0.0319 & 1.097 (0.855 to 1.408) & 0.4665 \\ \cline{2-6}  & Baseline lumen area & 2.904 (2.271 to 3.713) & \(<\)0.0001 & 1.974 (1.230 to 3.166) & 0.0048 \\ \cline{2-6}  & Baseline plaque & \multirow{2}{*}{1.038 (1.025 to 1.051)} & \multirow{2}{*}{\(<\)0.0001} & \multirow{2}{*}{1.018 (1.000 to 1.037)} & \multirow{2}{*}{0.0456} \\  & burden & & & & \\ \hline SmartFFR & 3.271 (1.103 to 9.704) & 0.0327 & 1.399 (0.179 to 10.901) & 0.7488 \\ \hline Minimum ESS (Pa) & 1.656 (1.470 to 1.865) & \(<\)0.0001 & 1.516 (1.165 to 1.972) & 0.0020 \\ \hline Maximum LDL  concentration & 1.612 (1.341 to 1.938) & \(<\)0.0001 & 1.326 (0.864 to 2.034) & 0.0014 \\ \hline \end{tabular}
\end{table}