# Modifications of Wound Dressings with Bioactive Agents to Achieve Improved Pro-Healing Properties
## 4 Patented and Commercial Bioactive Dressings  
Due to the high biomedical potential of some wound care products, more and more research units have decided to patent the method for wound dressing production. The European Patent Office holds thousands of patents covering wound dressings loaded with bioac \begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Type of** & **Composition of the** & & & **Biological Properties** & & \\
**Biomaterial** & **Biomaterial** & **Experimental Model** & & & **and Advantages** & \\ \hline Foam-like, & & & & Enhanced fibroblasts viability and & & \\ hydrocolloid & & & & & proliferation, supported & \\ type & & & & & platelet-derived growth factor & \\  & & & & (PDGF-BB) synthesis & & \\ \hline Film & Vitamin C, Brazilian & & & & \\ propols, cellulose, PVA & & & & & \\ \hline Membrane & & & & & \\  & & & & & \\  & & & & & \\  & & & & & \\ \hline Nanofibrous scaffold & & & & & \\  & & & & & \\  & & & & & \\  & & & & & \\ \hline Hydrogel & & & & & \\  & & & & & \\  & & & & & \\  & & & & & \\ \hline Hydrogel & & & & & \\  & & & & & \\  & & & & & \\  & & & & & \\ \hline Hydrogel & & & & & \\  & & & & & \\  & & & & & \\  & & & & & \\ \hline  & & & & & \\ \hline  & & & & & \\ \end{tabular}
\end{table} 
Table 3: Vitamin-enriched biomaterials for wound healing applications. tive agents. Our previous research resulted in two Polish patents (PL 236368, PL 236367) describing the production methods of foam-like and hydrogel-type curdlan/agarose dressing materials (Figure 4). Both types of developed wound dressings can be produced with the addition of bioactive compounds, such as vitamins, growth factors, antibiotics, or curcumin, which is reserved in the patent description. As a result of the incorporation of bioactive compounds, it is possible to obtain the preferred properties of the biomaterial and adapt it to a specific type of wound. Chinese patent, specification no. CN107475812A, describes the production method of a bioactive wound dressing based on chitosan and curcumin using electrostatic spinning. The described method allows users to obtain a porous structure of a biomaterial with antibacterial (_E. coli_) and anti-inflammatory properties. Moreover, due to the highly specific surface area of the biomaterial, it can be loaded with numerous drugs, acting as a drug delivery system. Another Chinese patent, specification no. CN110025817A, discloses a method for preparing a composite antibacterial fiber dressing containing essential oils. The obtained bioactive wound dressing is characterized by good permeability and antibacterial properties against _E. coli_ and _S. aureus_. A Taiwan patent, specification no. TW201208717A, discloses a method for production of a bioactive wound dressing containing citrus extract. The method of wound dressing production with the citrus extract content is based on the wet spinning technique or soaking method. Conducted tests on chitosan biomaterial loaded with citrus extract showed enhanced cell proliferation and angiogenesis. Another Chinese patent, specification no. CN105963753A, describes the production method of an anti-bacterial film. The biomaterial described in the patent is a multicomponent dressing containing natural plant ingredients (margidol oil, tea polyphenols, red oak powder, and calendula oil) that contribute to its non-toxicity, good elasticity, and anti-infective properties. The biomaterials presented within this article are the result of scientific activities and presently are not used in practice. However, there are many bioactive wound dressings currently available on the world market that are in wider usage as a medical wound care product. On the list of companies offering wound care materials, there are some that produce dressings enriched with a substance that accelerates the regeneration process. The German company Hartmann offers the HydroClean plus superabsorbent wound dressing, which is activated with Ringer's solution and contains polyhexanide (PHMB).