There is no uniform and accurate definition of biopesticides globally. In 2017, the FAO/WHO jointly published the Guidelines for the Registration of Biopesticides of Microbial, botanical and Pheromone Classes for Plant Protection and Public Health, which means that biopesticides include microbial pesticides, botanical pesticides, and pheromone pesticides, while natural enemies, genetically modified organisms, and chemically synthesized substances with the same structure as natural compounds do not belong to this category [12]. In the United States, biopesticides refer to naturally existing substances that have pest control efficacy and function through non-toxicological mechanisms, including biochemical pesticides, microbial pesticides, and genetically modified protectants. It is worth noting that under the definition issued by the EPA, not all naturally occurring substances are biopesticides; for the sake of management, _pyrethrins_, _spinosad_, _asermectins_, etc., are still registered and managed according to chemical pesticides [13]. According to the Pesticide Registration Data Requirements implemented in China in 2017, biopesticides include three categories of biochemical pesticides, microbial pesticides, and botanical pesticides. Agricultural antibiotics are produced through microbial fermentation and therefore belong to the microbial pesticide category of biopesticides but are basically equivalent to chemical pesticides in terms of registration criteria and others [14]. It can be found that most countries and organizations generally recognize microbial pesticides and biochemical pesticides as biopesticides. FAO, the United Kingdom, Australia, China, and other countries and organizations recognize that pesticides of botanical origin also belong to biopesticides. The United States, Canada, and other countries recognize genetically modified insecticid crops PIP as also belonging to biopesticides. In this paper, biopesticide refers to a formulation made from living organisms or their metabolites that has a killing or inhibiting effect on agricultural pests, including microbial-derived pesticides, botanical pesticides, natural enemy itself, animal-derived pesticides, antibiotics, biochemical pesticides, and plant-incorporated protectant (PIP) [15; 16; 17]. Compared with chemical pesticides, biopesticides have outstanding safety advantages. Firstly, biopesticides are more easily degradable. From a microscopic point of view, the ingredients of biopesticides are substances that exist in nature, which are easily decomposed and have a shorter safety interval, and do not cause major damage to the ecological balance. Secondly, biopesticides produce no or low residues. [PERSON] et al. compared the effects of the application of the chemical pesticides _chloryrifos_, _cypermethrin_, and the biopesticide _azadirachtiu_ on the production of inter-root bacterial communities in _covape_ and found that the residual concentrations of _chloryrifos_ and _cypermethrin_ in soil were 0.18 mg/kg and 0.86 mg/kg, respectively, at low doses and 0.36 mg/kg and 4.02 mg/kg, respectively, at high doses. While The residue levels of _azadirachtin_ were not detected [18]. Up to now, there are no reports of residues or persistent toxicity of botanical biopesticides such as azadirachtin in the environment [19]. Thirdly, the toxicity of biopesticides is generally lower. For example, biogenic information compounds, synthesized artificially from plants, insects, etc., are released slowly into the field using a release device to interfere with the mating, feeding, and other behaviors of insects, thus reducing the population of target pests. This mechanism does not affect other organisms. [PERSON] et al.