## 1 Introduction  
Many studies have been applied to achieve controlled drug delivery systems. Although different drug delivery systems have been developed, the introduction of a new strategy that can achieve the goals of controlled drug delivery is still felt. Zeolites are highly regarded as targeted drug delivery because of their mesoporous structure [1; 2; 3].  
The research for polymeric drug delivery has been developed for the last three decades [4; 5; 6]. Providing new polymeric drug delivery systems methods are among the significant concerns of pharmaceutical researchers regarding their ability to release active parts for a more extended period without changing the plasma level [7; 8; 9]. Biodegradable polymers have received much attention for drug delivery recently because of their bio-compatible and biodegradable nature [10; 11; 12]. The primary issue with non-biodegradable polymers is removing this polymer from a body after releasing the drug. Thus, biodegradable polymers are preferred more than non-biodegradable polymers for formulating drug delivery systems [13; 14]. Because they break down into small monomers in the body, determining whether their monomers are non-toxic or toxic is essential. As a result, introducing new types of biodegradable drug-delivering formulations is of high necessity to target specific areas of the body, such as tumors and inflammation [15; 16; 17].  
Cyclodext (CDs) are cyclic oligosaccharides synthesized from the enzymatic degradation of starch. The three mains, CDs, and many derivatives are produced on a large scale and studied extensively for use as drug carriers. The advantages involved in using CDs in drug delivery include flexibility in cavity size, a chemical structure with many potential chemical modification sites, the ability to preserve the structural integrity of degradable drug molecules, the ability to control the release rate profile of complex drugs, and low toxicity [18; 19; 20].  
Biodegradable polymers (BPs) are broadly used in gene therapy, ocular, tissue engineering, vascular, drug delivery, the promotion of plant growth, and heart valve replacements (Dacon, Teflon, and polyurethane). They may occur in both natural and synthetic forms. Synthetic BPs have several advantages over natural, including their unlimited resources, and being synthesized with different physical and chemical properties. Synthetic BPs can be synthesized from a reported method to give the same polymer [21; 22; 23].  
Citric acid (CA) is a multipurpose chemical compound that plays a crucial role in the Krebs cycle and is used in the food, beverages, pharmaceutical, agriculture, and metal industries. Nowadays, CA is considered an effective multifunctional monomer for biological synthesis. CA plays roles in co-forming ester cross-linking to improve compatibility coordination, balance the hydrophobicity of the polymer network, and provide other hydrogen bonding and binding sites for biocompatibility [24; 25].  
CA modified \(\beta\)-Cyclodextrin (\(\beta\)-CD) polymers have been used for drug delivery systems. In this regard, the synthesis of a porous silicon-cyclodextrintrin-based polymer as a carrier for ciprofloxacin and prednisolone delivery [26], CA-\(\gamma\)-cyclodextrintrin cross-linked oligomers for doxorubicin delivery [27], and citrate-modified \(\beta\)-CD functionalized magnetite nanoparticles as curcumin delivery have been reported [28]. Using nanozoelite (NZ) with a water-insoluble \(\beta\)-CD polymer cross-linked by CA can be an efficient carrier for hydrophobic drugs and the delivery of water-insoluble drugs. The presence of a natural zeolite can be a biological, economically feasible, and eco-friendly means for synthesizing the nanocarrier. The present study reports the synthesis, characterization, and studies on IB loaded on poly (\(\beta\)-cyclodextrintrin-_co_-citric acid) entrapped NZ.