## 4 Conclusions  
_Laureliopsis philippiana_ essential oil was chemically characterized, and its main components were \(\beta\)-Linalool, \(\beta\)-Isosafrole, Eucalyptusptol, and Methyleleugenol. In addition, it showed high inhibitory antibacterial activity against Gram-positive _S. aureus_ and Gram-negative  
Figure 6: Chemical structure of the most abundant compounds in _Laureliopsis philippiana_ essential oil: \(\beta\)-Linalool (**A**), \(\beta\)-Isosafrole (**B**), Eucalyptusptol (1,8-Cineole) (**C**) and Methyleleugenol (**D**). \begin{table}
\begin{tabular}{c c c c} \hline \hline \multirow{2}{*}{**Sample**} & \multicolumn{2}{c}{**Akaike Information Criterion (AIC)**} & \multirow{2}{*}{**F-Value**} \\ \cline{2-3} \cline{5-5}  & **First-Order** & & **Korsmeyer–Peppas** \\ \hline nPSi-Ox & 34.62239 & 44.19362 & ns \\ nPSi-UAc & 40.89699 & 49.53074 & ns \\ nPSi-APTS & 28.16102 & 49.58153 & ns \\ nPSi-Chi & 48.77567 & 44.39639 & 14.89 * \\ nPSi-GCD & 25.50497 & 46.01561 & ns \\ \hline \hline \end{tabular}
\end{table} 
Table 3: Model comparison by AIC and F-Value. _K. pneumonia_ in comparison to mineral oil. The chemical functionalization of nPSi was demonstrated as an effective alternative to allow loading and controlled kinetic release of _L. philippiana_ essential oil. The presence of different degrees of interaction of the essential oil components with the nPSi structures was demonstrated by the loading/release of the essential oil over time. The release profiles were studied for up to 4 h. According to the kinetics data, the diffusive mechanism of essential oil release was better explained by the First-order and Korsmeyer-Peppas models, suggesting a quasi-Fickian diffusion mechanism. Between all functionalizations studied in this work, nPSi-APTS and nPSi-UAc presented the best controlled release due to the interaction of the substrate with the essential oil. Finally, these results could indicate that _L. philippiana_ essential oil may increase its sustained release time into the environment through the use of functionalized nPSi structures, which is interesting due to the scarce reports about it and its potential applications in the biomedical sector. The following supporting information can be downloaded at: [[https://www.mdpi.com/article/10.3390/app12168258/s1](https://www.mdpi.com/article/10.3390/app12168258/s1)]([https://www.mdpi.com/article/10.3390/app12168258/s1](https://www.mdpi.com/article/10.3390/app12168258/s1)), Figure S1. Comparison of bacterial growth inhibition of essential oil in different years. The effect of different volume/volume ratio of essential oil (solid line) and three-year-old essential oil (segmented line) was evaluated using (A) _Staphylococcus aureus_ and (B) _Klebsiella pneumoniae_. The essential oil three-year-old result was from 1 independent experiment (_n_ = 1). Table S1. Incubation protocol for the antibacterial evaluation of _L. philippiana_ essential oil and mineral oil. Conceptualization, G.R.-S., A.P.-S.M. and K.U. ; porous silicon synthesis, A.P.-S.M. and K.U. ; porous silicon functionalization, A.P.-S.M., K.U. and J.H.-M.; physicochemical characterizations, K.U., N.N. and M.M.-S.; release profiles, A.P.-S.M. and K.U. ; mathematical analysis, A.P.-S.M. and J.H.-M.; biological characterizations, P.O., V.D.-G. and B.C. ; writing--original draft preparation, G.R.-S., A.P.-S.M. and K.U. ; project administration, G.R.-S. All authors have read and agreed to the published version of the manuscript. This research was funded by the National Agency for Research and Development (ANID) of Chile through the grants DOCTORADO NACIONAL/2020--21201805, CONICYT PFCHA/DOCTORADO/2017-21172001, and FONDECYT POSTDOCTORADO 3190734. Not applicable. The data that support the findings of this study are available from the corresponding author upon reasonable request. [PERSON] thanks Ph.D. Program \"Ciencias Agropecuarias\" from Universidad Catolica de Temuco.