## 1 Introduction  
Plants have been used by humans as both food and medicine since prehistoric times. Currently, there is an interest in the use of bioactive compounds, especially polyphenols, derived from plant materials in food preservation, pharmaceuticals, cosmetics, and natural pesticides. These bioactive compounds can play a preventive or supportive role in the treatment of various metabolic disorders and diseases due to their antioxidant, antimicrobial, anticancer, and anti-inflammatory properties [1]. _Laminum album_, widely known as non-sting nettle or white dead nettle, is a perennial herbaceous plant with white blooms that is inherent to Europe, Western Asia, and North Africa [2]. It belongs to the _Lamiacene_ family, which is recognized for producing plant species high in different bioactive compounds that generally differ in structures, biological properties, and mechanisms of action. Furthermore, the genus _Laminum_ contains nearly 40 species; among them, the _Laminum album_ is the most widely distributed species [3]. It has a wide variety of biological activities due to its various phytochemicals such as iridoids, flavonoids, triterpenes, fatty acids, polysaccharides, saponines, phytoecdysteoroids, phenolic acids, amines, essential oils, tannins, and mucilage [4]. Flowers and leaves of the Laminum album are considered food for humankind [2]. They can be eaten raw or cooked. It is also used in teas, dietary supplement products, and its intake is primarily connected with its health benefits [2; 5]. The dried flowers of this plant have demonstrated uterotonic, as stringent, antispasmodic, and anti-inflammatory activities and consequently are used in menorrhaging, uterine hemorrhage, vaginal and cervical inflammation, and leukorrhea treatment [3; 6]. Additionally, _L. album_ flowers have been reported to possess antioxidant, free radical scavenging, and antiproliferative properties [3]. Nowadays, the beneficial understanding of natural products has been substantially increased and scientifically proven, allowing a better grasp of their valuable features. Therefore, a significant quantity of information regarding the efficacy of _L. album_ extracts and raw material has been accumulated, and several health-related benefits have been successfully verified. Various studies in vivo or in vitro of _Laminum album_ extracts (methanol, ethyl acetate and heptane, butanol, ethanol, and chloroform) have been done, and their antioxidant, cytoprotective, anticancer, antiviral, antimicrobial, and antiproliferative activities have been reported [5; 7; 8; 9]. Additionally, bioactive phenolic compounds of this plant were also studied, and the results have shown that the crucial compounds mainly include; phenylpropanol weldasoside, isoscutellarein derivatives, and isoverbasoside, some phenolic acids such as caffe acid, ferulic acid, syryngic acid, and flavonoids [4; 5]. Various conclusions from the mentioned studies have shown a possible correlation between phenolic compounds and the antioxidant activity of this plant and its natural health benefits [8]. Despite all of the positive attributes claimed to the _Laminum album_, there are very few publications on _L. album_, and the data are incomplete. It is vital to carefully study the properties of this plant using modern techniques, including advanced techniques for bioactive extraction such as ultrasound, pulsed electric field, extrusion, microwave heating, ohmic heating, supercritical fluids, and accelerated solvents as they improve the quantity, quality, and selectivity of bioactive components extracted from plant matrix [10] and advanced analytical techniques for identifying and quantitating different bioactive components such as ultrahigh-performance liquid chromatography with photodiode array or/and mass spectrometer (UPLC/PDA or LC/MS/MS), gas chromatography, etc., which have been claimed to be cost-effective, repeatable, accurate, linear, precise, and resilient.