## 2 Contaminants of Emerging Concern (CECs)
### Pharmaceuticals (PhACs)
in AM Arges river); Lyaponen (1-39) & [45] \\ \hline Along the Darube banks of Novi Sad / July and November 2011, March and May 2012, seasonal monitoring & Four compounds, including caffeine, sulfamethoxazole, chloramphenicol, and stay 2012, seasonal monitoring & Four compounds, including caffeine, sulfamethoxazole, chloramphenicol, and stay 2012, seasonal monitoring & Four compounds, including caffeine, sulfamethoxazole, chloramphenicol, and stay 2012, seasonal monitoring & Four compounds, including caffeine, sulfamethoxazole, chloramphenicol, and stay 2012, seasonal monitoring & Four compounds, including caffeine, sulfamethoxazole, and stay 2012, seasonal monitoring & Four compounds, including caffeine, carbamazepine, diazemap and metabolite & Surface waters (ng/L); Lyaponen (5.27-256); AM MM mode & [47] \\ \hline Middle and lower sector of the Danube & Five compounds, including: carbamazepine, in metabolite 10.11-August-September 2013 (DS3) & Five compounds, including: carbamazepine, in metabolite 10.11-MS-MS, MS-MS, MR mode & Surface waters (ng/L); Calvanazepine (20-46, max) in AM Arges river); Sulfamethoxazole (20-255, max. in AM Arges river); Lyaponen (1-39) & [45] \\ \hline Alog the Darube banks of Novi Sad / July and November 2011, March and May 2012, seasonal monitoring & Four compounds, including caffeine, sulfamethoxazole, chloramphenicol, and stay 2012, seasonal monitoring & Four compounds, including caffeine, sulfamethoxazole, chloramphenicol, and stay 2012, seasonal monitoring & Four compounds, including caffeine, sulfamethoxazole, chloramphenicol, and stay 2012, seasonal monitoring \begin{table}
\begin{tabular}{l l l l} \hline \hline
**Sampling Site/Sampling Moment** & **Monitored Contaminants** & **Analytical Approach** & **Relevant Environmental Concentrations Range** & **Ref.** \\ (**Data**) & & & **for the Detected Compounds in Analysed** & **Ref.** \\  & & & **Matrices** & \\ \hline
16 samples from Dan Danne river and from three of the main effluents: Stret, Ott, Arges 4 samples from Danhe Delta/ & 36 compounds, including macrolides, benzimidazole, tranquilizers, macrolides, sulfemamides, quintomides, penicillins, targeted analysis in sID mode & Surface waters (ng/L): Carbamazepine (4-40, max. in Angs tributary); Sulfematheoxazole (2.5-30); Tinetrophin (S-12); Tinetrophin (S-12) & \\ May, June, August and October 2014 & & Targeted analysis in sID mode & Moderate (4-8,66 max. in Angs HRV); Tinetrophin (S-55, max. in Stret tributary); Napponen (6-12-22) & [10] \\ \hline
3 samples from the Danne river and 2 samples from tributary Sirt and Prut & 15 compounds, including macrolides, benzimidazole, tranquilizers, macrolides, sulfemamides, quintomides, penicillins, targeted screening method & Surface waters (ng/L): Tinetrophin (2-25); Sulfematheoxazole (3-30); Dodecircol (2-50); Cudammazepine (2-20); Phytromycin (2-25) & \\ April 2012 & & & \\ regular, occoidistats & & \\ \hline \hline \end{tabular}
\end{table} 
Table 1: _Cept._The selection of the monitored compounds in the listed studies (Table 1) was generally based on the occurrence in the aquatic environment, documented in previous reports or published data [10; 39], frequency and magnitude of the pharmaceuticals usage [46], and updated priority substances [36; 37]. Frequently monitored classes were: penicillins, macrolide and sulphonamides antibiotics, trimethoprim, antineepileptic carbamazepine, NSAIDs, lipid regulators, psychiatric drugs (benzodiazepepines), diquetes, antidiabetic, etc. More than 40 unregulated PhACs were reported in the listed publications (Table 1). Six studies reported the identification of metabolites for carbamazepine, aminophenazone, ibuprofen, metamazole, and others. The most reported antibiotic herein reviewed was sulfamethoxazole, followed by trimethoprim, and erythromycincin. Among NSAIDs, the most reported was ibuprofen, followed by diclofenac.