## 1 Introduction  
Oral disorders, whether localized or generalized, can affect speech, function, nutritional status, and appearance, which can lead to a reduction in social interactions and family life [1]. The \"oral health-related quality of life (OHRQoL)\" questionnaire emphasizes the aspects of people's lives affected by oral disease. The OHRQoL not only analyzes pain and physical functioning but also evaluates life satisfaction and social and psychological functioning [2]. Conventionally, patient management in dentistry and medicine is based on the clinical signs and symptoms of a particular disease by the clinicians, with less contribution from patients [3]. As patients can convey facts regarding changes in their social life and oral functions because of painful oral conditions, patient-based outcomes can be a component of the decision-making process [4, 5]. Currently, the impact of edentulism and denture prescription on quality of life is increasingly recognized as an important component of therapy and outcome measures in clinical trials [6]. In this regard, denture stomatitis (DS) is one of the most prevalent oral lesions. The swelling, erythema, and edema of the oral mucosa covering the hard and soft palate are the obvious signs and symptoms of DS and may not be diagnosed or treated expeditiously [7]. Denture stomatitis, an inflammation of the denture-bearing mucosa, can be caused by various factors, including poor denture hygiene, _Candida albicans_ overgrowth, and trauma. Its classifications include simple DS, characterized by erythema, edema, and sometimes pain; _Candida_-associated DS, with erythema, edema, and pseudomembrane formation; angular cheilitis, an inflammation of the skin at the mouth's corners; and linear gingival erythema, a red, edematous, and sometimes painful inflammation of the marginal gingiva. A specific classification depends on an individual's presentation. The prevalence rate of denture stomatitis among denture wearers varies widely depending on the study population, with estimates ranging from 15% to over 60% [8]. The etiology of the disease is unclear but is closely associated with a carbohydrate-rich diet, poor oral hygiene, vitamin deficiency, and the judicious wearing of dentures. It is more prevalent in immunocompromised patients. The opportunistic organism _Candida albicans_ is commonly associated with denture stomatitis. The organism is mostly found on denture surfaces and the oral mucosal lining, especially in the posterior tongue region [9]. Denture stomatitis commonly appears and affects the elderly population with dentures, and the inflammatory lesion negatively affects their quality of life [6; 9]. The orthodox treatment for DS is antifungal drugs administered through topical and systemic routes [7]. The use of antifungal therapy comes with side effects. The long-term use of such drugs may lead to the development of microorganism strains that are resistant to the therapy and the recurrence of DS [10]. The optimal treatment has not been proposed in general; however, the application of contemporary techniques and equipment can deliver effective approaches. They may provide safe, efficient, user-friendly, and cost-effective treatment methods without the disadvantages of topical or systemic antifungal medication [11]. Anti-microbial photodynamic therapy (a-PDT) with various dyes and wavelengths is considered a contemporary method alongside low-level laser therapy. The a-PDT stimulates the \"biological cell's chromophores at appropriately low doses of visible wavelength light, which causes the generation of reactive oxygen species (singlet oxygen and superoxide's)\" [12; 13]. It is a proven fact that DS is caused by the superficial proliferation of _Candida_ species, which makes them accessible to photodynamic photons [14]. The principal advantage of using a-PDT is that it does not require the maintenance of a high level of drug dose, unlike topical and systemic antifungal drugs. A-PDT is beneficial even in the management of recurrent _candidal_ infections.