## 1 Introduction  
The endocrine system comprises endocrine glands, hormones, and target cells involved in reproduction, development, growth, metabolism, and stress response, thereby maintaining the living organism's homeostasis [1]. Hormones produced by the endocrine glands throughout the blood flow circulate in the whole organism and bind to receptors on target cells thus transmitting chemical signals or inducing hormone action. The endocrine system is present in all vertebrates ranging from fish to mammals and secretes similar hormones [2]. Synthetic or natural chemicals that have an abnormal effect on normal endocrine system function are called endocrine disruptors. The exact definition of endocrine disruptors is different for various organizations, such as the United States Environmental Protection Agency [3] or the Organization for Economic Co-operation and Development [4]. Therefore, a globally established list of endocrine disruptors is non-existent, and chemical substances with potential risks are estimated through prior research [5]. Unlike biological hormones, these endocrine disruptors are stable and not easily degraded; therefore, they remain in the environment or inside a living organism [6]. Additionally, due to their strong lipid affinity, endocrine disruptors can accumulate in fats and tissues of organisms along the food chain [7]. Chemicals that are estimated to disturb the endocrine system are very diverse, such as plastic plasticizers [8], pesticides [9], heavy metals [10], and persistent organic compounds [11]. Bisphenol A (BPA) is suspected to be a representative endocrine disruptor [12]. BPA is a compound synthesized from phenol and acetone in 1891 [13] and has been used since the 1950s to produce resilient and transparent polycarbonate plastics and epoxy resins [14]. This compound has been used for various purposes, including electronic equipment, medical devices, reusable bottles, food storage containers, canned food, and thermal paper recepits [13; 15; 16; 17]. The worldwide demand for BPA increases by 5% annually and is classified as a high production volume chemical in the United States [18]. As the use of BPA increases, it is frequently detected in human samples [19; 20; 21], as well as in environmental media [22; 23]. As BPA causes estrogenic activity [24; 25] and is detected at a high frequency in human, environmental, and product samples, concerns regarding its use have increased. According to the precautionary principle, Canada, the European Union, and the United States have banned the use of BPA in baby bottles [26]. Substances similar in structure to BPA are now used as an alternative [27]. As shown in Table 1, bisphenol analogs have two phenolic rings, and the types and positions of functional groups are slightly different. Since the key structure of bisphenol analogs is similar to the original compound, they can replace the role of BPA. However, there is a possibility that the toxicity resulting from the structure remains. BPA analogs are used in many consumer products and are frequently detected in urine samples of the general population [28], surface water [23], and indoor dust [22]. The zebrafish has become a powerful model for testing endocrine disruptors based on their higher fecundity, fast embryonic development, and a conserved neuroendocrine system, which are also observed in humans [2]. This small fish has a hypothalamus-pituitary-endocrine gland axis, which connects the central nervous system and the endocrine system. Depending on the prominent glands, the axis can be divided into the hypothalamic-pituitary-gonad (HPG) axis, hypothalamic-pituitary-thyroid (HPT) axis, and hypothalamic-pituitary-adrenal (HPA) axis. All axes cooperate with other neuroendocrine systems to control body physiology [2]. Both the technical and practical advantages have