## 2 Materials and Methods
### Synthesis of Chalcone Derivatives
\({}^{1}\)H NMR (400 MHz, CDCl\({}_{3}\)) \(\delta\): 12.77 (s, 1H, OH), 7.91 (dd, \(J_{1}\) = 8.0, \(J_{2}\) = 1.6 Hz, 1H, H2\({}^{\prime}\)), 7.89 (d, \(J\) = 15.8 Hz, 1H, H7), 7.63 (d, \(J\) = 15.4 Hz, 1H, H8), 7.51 (dddd, \(J_{1}\) = 8.5, \(J_{2}\) = 8.6, \(J_{3}\) = 1.6 Hz, 1H, H4\({}^{\prime}\)), 7.36 (dd, \(J_{1}\) = 7.8 Hz, 1H, H6), 7.26 (dd, \(J_{1}\)  
C3\({}^{\prime}\)), 120, 0 (s, C1\({}^{\prime}\)), 119.0 (d, C8), 118.8 (d, C5\({}^{\prime}\)). GC-MS m/z (rel. int.) = 258.21 [M]\({}^{+}\) (4), 224.12 (5), 223.18 (26), 165.18 (7), 147.11 (20), 121.13 (32), 101.10 (39), 93.13 (26), 65.12 (100). (E)-3-(4-(dimethylamino)phenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (**2i**): purple red crystals (yield 51%). C\({}_{17}\)H\({}_{17}\)NO\({}_{2}\). Mp = 163-165 \({}^{\circ}\)C. IR (ATR diamond, cm\({}^{-1}\)) = 3064 (C-H), 1661 (C=O), 1276 (C-N) cm\({}^{-1}\). \({}^{1}\)H NMR (400 MHz, CDCl\({}_{3}\)) \(\delta\): 13.18 (s, 1H, OH), 7.919 (d, \(J\) = 14.9 Hz, 1H, H7), 7.915 (dd, \(J_{1}\) = 8.3, \(J_{2}\) = 1.8 Hz, 1H, H2\({}^{\prime}\)), 7.56 (dd, \(J_{1}\) = 8.8, \(J_{2}\) = 1.8 Hz, 2H, H2, H6), 7.46 (ddd, \(J_{1}\) = 8.5, \(J_{2}\) = 8.2, \(J_{3}\) = 1.6 Hz, 1H, H4\({}^{\prime}\)), 7.45 (d, \(J\) = 15.1 Hz, 1H, H8), 7.00 (dd, \(J_{1}\) = 8.3, \(J_{2}\) = 1.0 Hz, 1H, H5\({}^{\prime}\)), 6.92 (ddd, \(J_{1}\) = 8.2, \(J_{2}\) = 8.0, \(J_{3}\) = 1.2 Hz, 1H, H3\({}^{\prime}\)), 6.68 (dd, \(J_{1}\) = 8.9, \(J_{2}\) = 2.8 Hz, 2H, H3, H5), 3.03 (s, 6H, H10). \({}^{13}\)C NMR (100 MHz, CDCl\({}_{3}\)) \(\delta\): 193.6 (s, C9), 163.6 (s, C6\({}^{\prime}\)), 152.4 (s, C4), 146.6 (d, C7), 135.7 (d, C4\({}^{\prime}\)), 130.9 (d, C2, C6), 129.4 (d, C2\({}^{\prime}\)), 122.4 (s, C1), 120.5 (d, C3\({}^{\prime}\)), 118.6 (s, C1\({}^{\prime}\)), 118.5 (d, C8), 114.4 (d, C5\({}^{\prime}\)), 111.9 (d, C3, C5), 40.1 (q, C10). GC-MS m/z (rel. int.) = 267.11 [M]\({}^{+}\) (6), 266.11 (3), 220.13 (9), 165.16 (8), 152.16 (3), 104.05 (11), 92.09 (21), 89.06 (39), 76.07 (100). (E)-3-(anthracen-9-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one (**2j**): orange crystals (yield 45%). C\({}_{23}\)H\({}_{16}\)O\({}_{2}\). Mp = 148-150 \({}^{\circ}\)C. IR (ATR diamond, cm\({}^{-1}\)) = 3046 (C-H), 1633 (C=O), 1157 (C-O) cm\({}^{-1}\). \({}^{1}\)H NMR (400 MHz, CDCl\({}_{3}\)) \(\delta\): 12.85 (s, 1H, OH), 8.98 (d, \(J\) = 15.6 Hz, 1H, H15), 8.45 (s, 1H, H8), 8.27 (dd, \(J_{1}\) = 9.4, \(J_{2}\) = 2.9 Hz, 2H, H3, H13), 8.02 (dd, \(J_{1}\) = 9.6, \(J_{2}\) = 2.9 Hz, 2H, H3, H13), 8.02 (dd, \(J_{1}\) = 9.6, \(J_{2}\) = 2.9 Hz, 2H, H6, H10), 7.81 (dd, \(J_{1}\) = 9.6, \(J_{2}\) = 1.4 Hz, 1H, H2\({}^{\prime}\)), 7.65 (d, \(J\) = 15.6 Hz, 1H, H16), 7.53-7.46 (m, 4H, H4, H5, H11, H12), 7.53 (ddd, \(J_{1}\) = 8.3, \(J_{2}\) = 8.3, \(J_{3}\) = 1.7 Hz, H4\({}^{\prime}\)) 7.08 (dd, \(J_{1}\) = 8.4, \(J_{2}\) = 1.0 Hz, 1H, H5\({}^{\prime}\)), 6.89 (ddd, \(J_{1}\) = 8.1, \(J_{2}\) = 8.1, \(J_{3}\) = 1.1 Hz, H3\({}^{\prime}\)). \({}^{13}\)C NMR (100 MHz, CDCl\({}_{3}\)) \(\delta\): 193.3 (s, C17), 163.9 (s, C6\({}^{\prime}\)), 142.7 (d, C15), 136.7 (d, C4\({}^{\prime}\)), 131.4 (s, C1), 130.0 (s, C7, C9), 129.8 (d, C6, C10, C2\({}^{\prime}\)), 129.5 (d, C3, C13), 129.1 (s, C2, C14), 128.9 (d, C4, C12), 126.7 (d, C5, C11), 125.6 (s, C3\({}^{\prime}\)), 120.1 (d, C8, C4\({}^{\prime}\)), 119.1 (d, C16), 118.8 (d, C5\({}^{\prime}\)). GC-MS m/z (rel. int.) = 324.22 [M]\({}^{+}\)(27), 281.96 (5), 268.48 (5), 203.17 (17), 202.14 (35), 200.18 (11), 178.27 (12), 124.79 (15), 121.01 (90), 93.12 (36), 65.05 (100). (E)-3-(furan-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one (**2k**): yellow crystals (yield 84%). C\({}_{13}\)H\({}_{10}\)O\({}_{3}\). Mp = 90-92 \({}^{\circ}\)C. IR (ATR diamond, cm\({}^{-1}\)) = 3128-3150 (C-H), 1669 (C=C), 1636 (C=O), 1158 (C-O) cm\({}^{-1}\).