## 4 Discussion
As a result, higher damping of electromagnetic field occurs, and ordering forces must be disrupted. The presence of electromagnetic field generated by living cells was experimentally confirmed [10; 11; 12], and increased damping in cancer tissue was detected [52; 53; 54; 55]. The idea of electromagnetic control over biochemical reactions is a hypothesis only, although partially supported by a massive influence of electric field on enzymatic reactions discussed in [14; 15]. If valid, the hypothesis would shed light to the origin of genome mutations in a cancer cell. It is well-known that microparticle parameters are affected by an electric field [73], in particular, frequency and energy of oscillations--vibrational Stark effect [74; 75]. We suggest that chemical reactions might be triggered and controlled by a coherent electromagnetic field (reverse vibrational Stark effect), which generates resonant frequency components [9]. In such a case, a virus is able to disturb the bond if it produces a resonant electromagnetic field of sufficient power (sufficient number of photons in the time of bonding) in comparison with the biological source. If the biological field is damped, the probability of virus bonding is increased. In the case of high-enough damping, randomized biochemical reactions may also occur [9], together with disturbed long-range organization forces of an electric and electromagnetic nature [76]. Numerous carcinogenic agents, such as tobacco tar, might then contribute to specificity of the mutation and thus accelerate the process of cancer initiation. Genome mutations are known to drive cancer progression. However, their role in cancer initiation is questionable, as specific oncogene mutations are not being found in all tumors in a given cancer type, while being absent in their healthy counterparts [77]. In other words, cancer transformation can occur without a specific mutation, while the mutation itself need not necessarily lead to cancer. Our model thus explains the mechanism of cancer initiation and suggests a hypothesis on its consequence--genome mutation. Even though the model is based on data of CMI response to the LDH virus antigen, it  
Figure 5: A schematic picture of physical pathological links in cancer development of the reverse Warburg effect (undifferentiated) phenotype. Pathological processes in a fibroblast associated with the cancer cell are similar to those in a cancer cell of the Warburg effect. Pathological transformation of the fibroblast is controlled by signaling from the tissue and from the cancer cell. Loss of stromal Cav-1 expression is a key condition for development of the reverse Warburg effect. The cancer cell is fueled by energy-rich metabolites produced by fibroblasts. may be valid for other oncogenic viruses as virus-induced ATP production by fermentative processes prior to the oxidative stage (Warburg effect) commonly occurs in infected cells [78]. Some viruses can even directly target mitochondria to affect their function, and induced alterations in their membrane potential are reported [79]. The generally presented knowledge of carcinogenesis contains only a part of cancer processes--the processes of biological and biochemical origin. Biophysical energy defects are often neglected. Biological systems should be also viewed as physical objects--open dissipative structures with dynamic stability sustained by exchange of matter, energy and information based on specific organized structure--solitons and generation of electromagnetic field [56]. Damped cellular electromagnetic activity may cause (1) loss of resonant interaction between cells, resulting in interrupted mutual communication and ordering forces, and (2) weakening the reverse vibrational Stark effect, resulting in genome mutations. Therefore, diagnosis of cancer initiation should be based on detecting changed physical parameters, such as resonant frequencies, the presence of parasitic energy consumption, and decrease of respiration energy processes.