## 2 Drifting from Molecular to Clinical Evidence
### Cardioprotective Activity  
#### 2.1.1 Atherosclerosis  
There are several randomized, double-blinded, and placebo-controlled clinical trials assessing the anti-atherosclerotic activity of allicin-containing products (Table 1), such as garlic powder tablets, capsules containing AGE (aged garlic extract) and even the Allicor garlic-based drug. Figure 1: Allicin chemical structure and its formation. \begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Clinical Trial** & **Participants** & **Duration** & **Dose** & **Summary** & **References** \\ \hline \hline \multicolumn{5}{c}{Abbreviations} \\ \hline \hline \multicolumn{5}{c}{Prague volume in the whole collective remained practically constant within the age-span of 50-80} \\ R, DR, PC & 152 individuals & 48 months & High-dose gastric powder & years, substantiating out only a garlic precursor but probably a curative rule in radiotechnosis \\ \multicolumn{5}{c}{(glabor expansion)} \\ \hline \hline \multicolumn{5}{c}{Complex contagative model generated generated generated generated generated generated generated generated generated} \\ R, DR, PC & 65 individuals & 12 months & (505 mg/s) using Illumina [12.00 (200.00)] & April garlic extract supplemented with sulphur was associated with a favorable improvement in explosive behavior, vascular function, and reduced atherosclerosis progression \\ \multicolumn{5}{c}{explotype biomarkers, vascular function, and reduced atherosclerosis progression} \\ \hline \hline \multicolumn{5}{c}{Critical-based drug-like contact-Prakana,} \\ R, DR, PC & 100 asymptotic mean & \multicolumn{5}{c}{Cark-based drug-like contact-Prakana,} \\ \hline \multicolumn{5}{c}{Absorbance, Rosario [200] (mg/s)} \\ \hline \hline \multicolumn{5}{c}{Aged particle extract (00 mg/s) uptake plus} \\ \multicolumn{5}{c}{CAD100 (0 mg/s) uptake} \\ \hline \hline \multicolumn{5}{c}{Hypectrum} \\ \hline \hline \multicolumn{5}{c}{R} & 50 individuals & 12 weeks & April garlic extract took up upsetting & April garlic extract took upsetting to placebo by showing marked frequent (similar to 24.5 mg/s) \\ \multicolumn{5}{c}{Generalized drug-like contact-Prakana,} \\ R, DR, PC & 80 individuals & 12 weeks & 24.5 mg/s) display & 5.24 mg/s) display & 5. \begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Clinical Trial** & **Participants** & **Duration** & **Dose** & **References** \\ \hline open-field study & 50 individuals & 90 days & 3 g of raw garlic daily & \ \begin{tabular}{c} Castile has a rule in cholesterol management as a diabetic therapy in most cases of significant \\ hypercholesterol, reducing the risk of atherosclerosis and cardiovascular events \\ \end{tabular}  & [34] \\ \hline R, DR, PC & 51 adults & 12 weeks & 500 or 1000 mg dehydrated garlic powder & No significant effect on patients (i) labels and therefore, more than two as indicated in a graded effect by the garlic accept vs. 500 and 1000 mg/day & [46] \\ \hline DR, R, PC & 31 individuals & 26 weeks & 900 mg Koral garlic (standardized to 60%), as shown in [34] & Antibody levels to oxidized LDL were unchanged, and (hyperosmotic) levels in gliomas also were not \\ \hline  & 96 individuals & 900 mg of \#ogle powder (standardized to 1,3,5,4) & & Significant reduction in total cholesterol, LDL + c, and triglycerides, and an increase in HDL+c & [42] \\ \hline  & 20 individuals & 4 weeks & 600 mg died garlic &
\begin{tabular}{c} Significant decrease in diagnoses and diagnoses. A and increase in strengthen-as-cruated \\ planning/aggine and Hospital  
Aged garlic extract supplementation with B vitamins, folic acid and L-arginine has been associated with the progression of subclinical atherosclerosis [24]. A two-year treatment with Allicor (garlic powder) exerted a direct anti-atherosclerotic effect on carotid atherosclerosis in asymptomatic men [25]. Also, the age-dependent representation of the plaque volume shows an increase between 50 and 80 years that is diminished under garlic treatment by 6-13% over 4 years.