## 1 Introduction  
As a biological antioxidant, molecular H\({}^{+}\) can selectively neutralize free radicals and exert anti-oxidative, anti-inflammatory, anti-apoptotic, and therapeutic effects on cells from various biological tissues and organs [1, 2, 3]. Another advantage of H\({}^{+}\) is its strong diffusion ability [4]. Cell membranes and various biological barriers do not affect the diffusion and penetration of H\({}^{+}\). H\({}^{+}\) can reach any part of the body and is considered to exert therapeutic effects in several common acute and chronic diseases, such as appoley [5], diabetes [6], arteriosclerosis [7], and Parkinson's disease [8]. H\({}^{+}\) gas has recently been recognized as an important gaseous signaling molecule (GSM) in biology and holds appealing potential in healthcare due to its ability to prevent various types of cellular injury [9, 10, 11, 12]. More recently, [PERSON] et al. reported that inhalation of hydrogen gas (XEN) once for 45 min attenuatedairway inflammation in patients with asthma and chronic obstructive pulmonary disease (COPD), mainly by inhibiting the pro-inflammatory cytokines monocyte chemoattractant protein-1 (MCP-1), interleukin-4 (IL-4), and IL-6 [13]. H\({}^{+}\) can be administered by inhaling H\({}^{+}\)[12], drinking H\({}^{+}\) water [2], or injecting H\({}^{+}\) brine [14]. Inhalation of H\({}^{+}\) has been shown to improve the symptoms of neurological [15] and cardiovascular diseases, such as apoplexy and myocardial infarction [16,17]. Drinking H\({}^{+}\) water has been reported to have therapeutic effects in diabetes and metabolic diseases [6,18]. In addition, drinking H\({}^{+}\) water has also been proven to improve hypersensitivity in animal models of diseases, such as atopic dermatitis [19]. Direct injection of H\({}^{+}\) brine into retinopathic eyeballs can treat fundus oculi diseases [20]. [PERSON] et al. (2015) administered high-concentration H\({}^{+}\) water in combination with the anticancer drug 5-fluorouracil in both cytological and animal models and reported that H\({}^{+}\) not only promoted tumor cell apoptosis but also significantly increased the anti-tumor effects of 5-fluorouracilacil and prolonged the lifespan of tumor-bearing animals [21]. As described above, molecular hydrogen can be ingested/delivered in various convenient ways, including inhalation [13], drinking hydrogen-dissolved water [2,22], injection of hydrogen-saturated saline [23] and taking a hydrogen bath [24]. Moreover, in contrast to other medical gases, such as carbon monoxide (CO), hydrogen sulfide (H\({}_{2}\)S), and nitric oxide (NO), H\({}_{2}\) offers the advantages of being non-cytotoxic [25], and can readily diffuse into tissues and cells [26] and cross the blood-brain barrier [27], suggesting this gas could potentially be used to treat brain tumors. However, first, a H\({}^{+}\) production machine is needed, which is bulky and requires a power source, and it is not easy to store the H\({}^{+}\) water produced. A high-pressure H\({}^{+}\) steel cylinder is usually used to produce high-purity H\({}^{+}\). However, in addition to the problem of non-portability due to the volume and weight of the cylinders, the potential safety risks of high-pressure gas steel cylinders are also of concern. H\({}^{+}\)-producing machines and high-pressure H\({}^{+}\) steel cylinders are inconvenient to transport, which limits the use of H\({}^{+}\) in practical applications [28]. Oxygen's critical role in the healing of wounds is well understood [29]. Wound healing is an energy-demanding process and oxygen is needed to support the respiration essential to release the required energy [30,31]. There has been significant progress in the transition from refining vascularization techniques to engineering oxygen-releasing biomaterials over the past decade [32]. Oxygen-releasing biomaterials can be fabricated through the incorporation of solid peroxides, liquid peroxides, and fluorinated compounds into the scaffold polymer.