## 3 Cardiovascular Disease
### Clinical Relevance
\begin{table}
\begin{tabular}{|p{42.7 pt}|p{42.7 pt}|p{42.7 pt}|p{42.7 pt}|p{42.7 pt}|} \hline \multicolumn{1}{|c|}{**Protein**} & \multicolumn{1}{c}{**Probe**} & \multicolumn{1}{c}{**Model and Species**} & \multicolumn{1}{c}{**Reference**} & \multicolumn{1}{c}{**General Application**} \\ \hline
**Collagen** & & & & & \\ \hline \multirow{3}{*}{EP-3533} & \multicolumn{3}{c}{Fibrosis in various disease including myocardial infarction (MI) model—mice (in vivo)} & [PERSON] et al., 2007 & Imaging of Type I collagen in fibrosis \\ \cline{2-5}  & \multicolumn{3}{c}{A Atherosclerotic model of plaque progression and regression—mice (in vivo)} & [PERSON] et al., 2013 & \\ \cline{2-5}  & \multicolumn{3}{c}{Healed myocardial infarction (MI)—mice (in vivo)} & [PERSON] et al., 2008 & \\ \cline{2-5}  & \multicolumn{3}{c}{CNA-35} & Atherosclerotic arteries—mice (ex vivo) & [PERSON] et al., 2007 & \
\begin{tabular}{c} Birds to all fibrillar collagens and \\ collagen type IV \\ \end{tabular} \\ \cline{2-5}  & \multicolumn{3}{c}{A Aortic aneurysms and rupture} & [PERSON] et al., 2011 & \\ \cline{2-5}  & \multicolumn{3}{c}{Clarid atherosclerotic plaques—human (ex vivo) and atherosclerotic model—mice (in vivo)} & [PERSON] et al., 2008 &
\begin{tabular}{c} Targeted to selectively visualise type I \\ and III \\ \end{tabular} \\ \hline
**Elastic** & & & & \\ \hline \multirow{3}{*}{ESMA} & \multicolumn{3}{c}{Arterial remodelling post stent—serine (in vivo)} & [PERSON] et al., 2011 & Quantification of elastin in plaque \\ \cline{2-5}  & \multicolumn{3}{c}{Plaque rupture—rabbit (in vivo)} & [PERSON] et al., 2014 & \\ \cline{2-5}  & \multicolumn{3}{c}{Matrix remodelling in a MI model—mice (in vivo)} & [PERSON] et al., 2014 & Quantification of elastin \\ \cline{2-5}  & \multicolumn{3}{c}{Aortic aneurysm remodelling—mice (in vivo)} & [PERSON] et al., 2014 & in myocardium \\ \hline \multirow{3}{*}{TESMA} & \multicolumn{3}{c}{Elastic remodelling in aortic wall in Marfan mouse model (in vivo)} & [PERSON] et al., 2014 & \\ \cline{2-5}  & \multicolumn{3}{c}{A Atherosclerosis model—mice and rabbits (in vivo)} & [PERSON] et al., 2018 &
\begin{tabular}{c} Tropoleastin selectively visualises \\ dysfunctional elastogenesis \\ or elastolysis \\ \end{tabular} \\ \cline{2-5}  & \multicolumn{3}{c}{Model of abdominal aortic aneurysm—mice (in vivo)} & [PERSON] et al., 2019 & \\ \cline{2-5}  & \multicolumn{3}{c}{} & \\ \end{tabular}
\end{table} 
Table 2: Summary of recent probe development in the field of cardiovascular disease (CVD) with indication to the ECM structure that they target. \begin{table}
\begin{tabular}{|l|l|l|l|l|} \hline \hline
**Protein** & **Probe** & **Model and Species** & **Reference** & **General Application** \\ \hline
**Collagen** & & & & \\ \hline
**Fibrin** & & Lipid encapsulated & Human thrombus (ex vivo) & [PERSON] et al., 2000 & Imaging of fibrin clots \\ \hline  & perfluorocarbon nanoparticle & & & & Targets and enhances signal \\ \hline Para-magnetic nanoparticle & Jugular vein—carine (in vivo) & [PERSON] et al., 2001 & & \\  & & & & in thrombi \\ \hline EP-1242 & Acute plaque thrombus—guinea pig & [PERSON] et al., 2005 & & \\ \hline EP-1873 & Plaque rupture model—rabbit (in vivo) & [PERSON] et al., 2004 & Imaging subacute plaque thrombosis \\ \hline  & Acute coronary thrombosis—swine (in vivo) & [PERSON] et al., 2004 & Detection of acute coronary \\ EP-2014R & and human translation & & & thrombosis \\ \cline{2-5}  & & & \\ \cline{2-5}  & & & & \\ \cline{2-5}  & & & \\ \cline{2-5}  & & & \\ \hline  & Mouse model of DVT—mice (in vivo) & [PERSON] et al., 2014 & \\ \hline FTP11-cy+NIRF & Deep venous thrombosis (DVT) & [PERSON] et al., 2012 & \\  & model—mice (in vivo) & [PERSON] et al., 2012 & \\ \hline \({}^{\text{\#}}\)Cu-FBP8 & Carotid artery and femoral vein & [PERSON] et al., 2015 & \\  & thrombosis—rodent (in vivo) & & \\ \hline \multicolumn{4}{l}{**Matrix Metalloproteinase (MMP)**} & & \\ \hline  & & &