## 3 Results  
The results are shown in Table 1. The effect size is larger than 0.80 for the conditioned pain modulation between measurements A and B and B and C. The rest of the outcome measures had small effect sizes.  
\begin{table}
\begin{tabular}{l l l l l l l l} \hline \hline
**Data Sampling Time** & \multicolumn{2}{c}{**A**} & \multicolumn{2}{c}{**B**} & \multicolumn{2}{c}{**C**} & \multicolumn{2}{c}{**A vs. B**} & \multicolumn{2}{c}{**A vs. C**} & \multicolumn{2}{c}{**B vs. C**} \\ \hline  & & & & & \(d\) & \(d\) & \(d\) \\ \hline \multicolumn{8}{l}{**Objective pain measurements**} \\ \hline Widespread mechanical & SD: 6.46 & 12.2 & 8.66 & 12.48 & \(-0.54\) & 0.04 & 0.59 \\ hyperalgesia & SD: 13.59 & 19 & 21 & 25 & 0.15 & 0.44 & 0.29 \\ \hline Conditioned pain modulation & SD: 1.31 & 2.36 & \(-0.78\) & 1.66 & \(\mathbf{-2.40}^{*}\) & \(-0.53\) & \(\mathbf{1.86}^{*}\) \\ \hline \multicolumn{8}{l}{**Pain, disability, quality of sleep and oral health**} \\ \hline PSQI & SD: 3.53 & 31 & 25 & 25 & \(\mathbf{-1.70}^{*}\) & \(\mathbf{-1.70}^{*}\) & 0 \\ \hline BPI & Intensity & 26 & 20 & 26 & \(\mathbf{-2.86}^{*}\) & 0 & 2.79 * \\ \hline  & Functionality & & & & & & \\  & SD: 2.25 & 49 & 39 & 45 & \(\mathbf{-4.44}^{*}\) & \(\mathbf{-1.77}^{*}\) & \(\mathbf{2.66}^{*}\) \\ \hline PCS & SD: 6.92 & 34 & 25 & 15 & \(\mathbf{-1.3}^{*}\) & \(\mathbf{-2.73}^{*}\) & \(\mathbf{-1.44}^{*}\) \\ \hline LANSS & SD: 5.38 & 14 & 9 & 5 & \(\mathbf{-0.93}^{*}\) & \(\mathbf{-1.68}^{*}\) & \(-0.75\) \\ \hline IDCP-1/2 & SD: 1.34 & 33 & 31 & 29 & \(\mathbf{-1.49}^{*}\) & \(\mathbf{-2.98}^{*}\) & \(\mathbf{-1.49}^{*}\) \\ \hline GOHAI & SD: 9.37 & 24 & 24 & 24 & 0 & 0 & 0 \\ \hline OHIP-14 & SD: 3.03 & 39 & 38 & 39 & \(-0.33\) & \(\mathbf{-3.34}^{*}\) & \(\mathbf{-3.01}^{*}\) \\ \hline \multicolumn{8}{l}{**Cognitive measures**} \\ \hline  & A & 92\({}^{\prime\prime}\) & 77\({}^{\prime\prime}\) & 69\({}^{\prime\prime}\) & \(\mathbf{-1}^{*}\) & \(\mathbf{-1.53}^{*}\) & \(-0.53\) \\ TMT & SD: 14.6 & & & & & & \\ \cline{2-8}  & B & 261\({}^{\prime\prime}\) & 160\({}^{\prime\prime}\) & 124\({}^{\prime\prime}\) & \(\mathbf{-1.40}^{*}\) & \(\mathbf{-1.89}^{*}\) & \(-0.49\) \\ \hline  & Word & & & & & & \\  & SD: 18 & 68 & 83 & 86 & \(\mathbf{0.83}^{*}\) & \(\mathbf{1}\) & 0.16 \\ \cline{2-8} Stroop & Color & & & & & & \\  & SD: 14 & 28 & 33 & 37 & 0.35 & 0.64 & 0.28 \\ \cline{2-8}  & Word-color & & & & & & \\  & SD: 10 & 16 & 13 & 18 & \(-0.3\) & 0.2 & 0.5 \\ \hline MoCA & SD: 3.7 & 21 & 27 & 26 & \(\mathbf{1.62}^{*}\) & \(\mathbf{1.35}^{*}\) & \(-0.27\) \\ \hline WAIS III: Digit-Symbol & SD: 17.68 & 18 & 26 & 30 & 0.45 & 0.67 & 0.23 \\ \hline  & State. SD: & & & & & & \\  & 11.93 & 25 & 22 & 28 & \(-0.25\) & 0.25 & 0.5 \\ \cline{2-8} STAI & Trait. SD: & & & & & & \\  & 10.05 & 15 & 19 & 18 & 0.39 & 0.30 & \(-0.10\) \\ \hline BDI-2 & SD: 10.9 & 29 & 25 & 30 & \(-0.09\) & \(-0.46\) & \(-0.37\) \\ \hline \multicolumn{8}{l}{Note: SD: standard deviation. PSQI: Pittsburgh Sleep Quality Index; BPI: Brief Pain Inventory. IDCP-1/2: Inventory of Disability and Craniofacial Pain; GOHAI: General Oral Health Assessment Index; OHIP: Oral Health Impact Profile; PCS: Pain Catastrophizing Scale; LANSS: Leeds Assessment of Neuropathatic Symptoms and Signs; TMT: Trail Making Test; MoCA: Montreal Cognitive Assessment; WAIS III: Wechser Intelligence Scale III; STAI: State– Trait Anxiety Inventory; BDI-2: Beck Depression Inventory II; A: day 1; B: day 15; C: day 45; _d A_ vs. B: value of _d Cohen_ between measurements A and B; _d A_ vs. C: value of _d Cohen_ between measurements A and C and \(d\) B vs. C: value of _d Cohen_ between measurements B and C. \({}^{*}\) Large effect size. \\ \hline \hline \end{tabular}
\end{table}
Table 1: Results and size of effect.