## 3 Results
The highest accuracies and AUC were achieved by FFS enhancement, global thresholding, FCM classifier and \begin{table}
\begin{tabular}{c c c c c c c} \hline \hline
**Contrast Methods** & & **Accuracy \%** & **Sensitivity \%** & **Specificity \%** & **F1 Score \%** & **AUC** \\ \hline \multirow{3}{*}{LH-CON} & K-means & 83.79 & 61 & 91.46 & 64.61 & - \\  & FCM & 93.79 & 76.84 & 98.3 & 82 & 0.86 \\  & ANFIS & 92.07 & 71.12 & 98.68 & 79.91 & 0.83 \\ \hline \multirow{3}{*}{LH-XWW} & K-means & 87.59 & 74.94 & 92.73 & 77.2 & - \\  & FCM & 94.14 & 79.44 & 98.21 & 85.27 & 0.84 \\  & ANFIS & 93.45 & 84.19 & 96.37 & 85.47 & 0.88 \\ \hline \multirow{3}{*}{IFS} & K-means & 81.38 & 76.54 & 83.1 & 70.58 & - \\  & FCM & 92.41 & 78.77 & 96.88 & 82.9 & 0.87 \\  & ANFIS & 92.07 & 71.5 & 96.78 & 78.46 & 0.81 \\ \hline \multirow{3}{*}{PFS} & K-means & 80.34 & 67.34 & 85.45 & 65.26 & - \\  & FCM & 92.41 & 72.9 & 96.98 & 77.87 & 0.8 \\  & ANFIS & 93.45 & 82.6 & 97.22 & 86.33 & 0.86 \\ \hline \multirow{3}{*}{FFS} & K-means & 86.9 & 77.68 & 90.11 & 77.39 & - \\  & FCM & **95.17** & 83.35 & 98.2 & **86.98** & **0.91** \\  & ANFIS & 93.79 & 80.61 & 97.75 & 83.75 & 0.85 \\ \hline \multirow{3}{*}{OWA-GA} & K-means & 83.79 & 77.72 & 85.05 & 70.61 & - \\  & FCM & 91.38 & 74.14 & 96.04 & 77.4 & 0.82 \\ \cline{1-1}  & ANFIS & 92.07 & 64.39 & 98.77 & 74.76 & 0.75 \\ \hline \multirow{3}{*}{OWA-HK} & K-means & 84.83 & 69.36 & 90.77 & 71.39 & - \\ \cline{1-1}  & FCM & 92.76 & 73.98 & 97 & 77.83 & 0.81 \\ \cline{1-1}  & ANFIS & 92.41 & 63.95 & 99.07 & 75.57 & 0.76 \\ \hline \hline \end{tabular}
\end{table} 
Table 1: Indicators for global thresholding method (The best scores are bold). LH-XWW enhancement, Otsu thresholding and FCM classifier, but the second combination reached a higher F1 score. \begin{table}
\begin{tabular}{c c c c c c c} \hline
**Contrast Methods** & & **Accuracy \%** & **Sensitivity \%** & **Specificity \%** & **F1 Score \%** & **AUC** \\ \hline \multirow{3}{*}{LH-CON} & K-means & 86.55 & 79.03 & 88.7 & 75.78 & - \\  & FCM & 92.76 & 82.89 & 96 & 83.89 & 0.9 \\  & ANFIS & 91.03 & 61.53 & 98.21 & 72.17 & 0.73 \\ \hline \multirow{3}{*}{LH-XWW} & K-means & 87.24 & 66.92 & 93.11 & 69.24 & - \\  & FCM & **95.17** & 88.41 & 97.32 & **89.42** & **0.91** \\  & ANFIS & 90.69 & 72.34 & 96.02 & 76.09 & 0.8 \\ \hline \multirow{3}{*}{IFS} & K-means & 80.34 & 65.31 & 85.01 & 63.76 & - \\  & FCM & 92.76 & 73.79 & 97.81 & 79.39 & 0.83 \\  & ANFIS & 91.03 & 67.63 & 96.43 & 73.76 & 0.77 \\ \hline \multirow{3}{*}{PFS} & K-means & 81.38 & 70.09 & 83.74 & 64.25 & - \\  & FCM & 92.76 & 73.96 & 97.01 & 79.74 & 0.79 \\  & ANFIS & 93.1 & 80.26 & 97.59 & 85.98 & 0.86 \\ \hline \multirow{3}{*}{FFS} & K-means & 80.69 & 74.41 & 83.59 & 65.43 & - \\  & FCM & 91.38 & 74.06 & 97.07 & 81.12 & 0.8 \\  & ANFIS & 92.07 & 69.26 & 97.82 & 76.77 & 0.75 \\ \hline \multirow{3}{*}{OWA-GA} & K-means & 81.03 & 82.45 & 79.64 & 73.22 & - \\  & FCM & 92.07 & 79.83 & 95.9 & 82.29 & 0.87 \\  & ANFIS & 92.41 & 64.79 & 98.71 & 75.39 & 0.77 \\ \hline \multirow{3}{*}{OWA-HK} & K-means & 78.62 & 43.31 & 89.66 & 45.84 & - \\  & FCM & 92.76 & 74.82 & 97.3 & 81.64 & 0.84 \\ \cline{1-1}  & ANFIS & 92.41 & 70.25 & 98.67 & 79.83 & 0.83 \\ \hline \end{tabular}
\end{table} 
Table 2: Indicators for Otsu thresholding method (The best scores are bold).