###### Abstract  
Web platforms are gaining relevance in eHealth, where they ease the interaction between patients and clinician. However, some clinical fields, such as the cardiovascular one, still need more effort because cardiovascular diseases are the principal cause of death and medical resources expenditure worldwide. The lack of daily control is the main reason hypertension is a current health problem, and medical web services could improve this situation. To face this challenge, this work proposes a novel intelligent web-based ecosystem, called SENIOR, capable of predicting adverse blood pressure events. The innovation of the SENIOR ecosystem relies on a wearable device measuring patient's biomarkers such as blood pressure, a mobile application acquiring patient's information, and a web platform consulting environmental services, processing data, and predicting blood pressure. The second contribution of this work is to consider novel environmental features based on the users' location, such as climate and pollution data, to increase the knowledge about known variables affecting hypertension. Finally, our last contribution is a proof of concept with several machine learning algorithms predicting blood pressure values both in real-time and future temporal windows within one day has demonstrated the suitability of SENIOR. eHealth; web-based platforms; distributed services and platforms; artificial intelligence; hypertension; telemedicine; personalized medicine +
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Cardiovascular diseases are the leading cause of death and medical resource expenditure globally, being high blood pressure (HBP, also known as hypertension), a significant risk factor for cardiovascular diseases. Although resources have been invested in reducing the impact of this condition, hypertension remains a direct cause of mortality, loss of quality of life, and consumption of healthcare resources. A study of the hypertension situation between 1980 and 2015 [1] showed that the number of individuals with high blood pressure increased from 442 to 874 million people in this period. From the age of 69 onward, this percentage augmented to 60%. It is expected that the incidence of this disease will increase by 2025, with an estimation of around 1.5 billion people affected worldwide. Additionally, deaths associated with HBP have increased by 1.6% per year during this period, from 7.2 to 10.7 million people. In 2015, 14% of all deaths were associated with hypertension, related firstly to ischemic heart disease and, secondly, to cerebrovascular accident. This has placed blood pressure as a risk factor in an increasing number of diseases and events such as dementia or the risk of cognitive impairment, applying to all age and ethnic groups. [PERSON] et al. [2] reported that individuals with hypertension are much less productive, highlighting the enormous benefits that a better identification, treatment, and control of the disease could have. Most cases of hypertension appear to be caused by reversible environmental factors, being the most critical weight gain leading to obesity, insufficient physical activity, inadequate sodium and potassium intake, and alcohol abuse [3]. Based on that, the main strategy to control HBP is implementing lifestyle changes before or during drug treatment, as long-term control of the disease has been achieved in these cases [3; 4; 5]. Additionally, blood pressure measurements at home are essential to control the status of the disease actively. Nevertheless, only a small percentage of patients follow these recommendations since implementing effective strategies leading to sustained lifestyle changes is difficult [6]. The goal to stabilize this condition is to bring most patients to a scenario where all these lifestyle deficiencies are addressed. Considering the inefficiency of traditional methods to control HBP, the literature has defined and implemented web-based systems aiming to support clinical monitoring of hypertension patients [7].