related to Internet of Things (IoT) to create ICT solutions to improve people's health and well-being. A healthcare system can be defined as a set of hardware and software tools designed to provide a broad range of healthcare services and applications to individuals, such as medical staff and patients, aiming to promote health and well-being in in in an effective and often pervasive manner. Healthcare systems are closely related to ELE and AAL. AAL systems present an efficient potential to address several healthcare challenges through ICT. Moreover, ELEs incorporate an ecosystem of healthcare systems, which include medical sensors, microcontrollers, wireless communication technologies, and open-source software platforms, for data visualization and analytics. AAL systems provide pervasive methods and ambient intelligence to design ELE applications that incorporate healthcare systems able to provide 24/7 continuous monitoring and control of the environment. ELE include healthcare systems that directly or indirectly help to maintain people within their home environments instead of being moved into institutionalized environments. Moreover, these systems provide efficient methods to improve individuals' independence and facilitate medical treatments. Currently, there are different healthcare systems that incorporate several technologies to monitor several human physiological status and environmental parameters using different wireless communications technologies, such as ZigBee, 3G, Bluetooth, Ethernet, and Wi-Fi [3]. On the one hand, human physiological status monitoring provides medical state perception and is particularly important for at-risk individuals, such as older adults and newborns, to detect symptoms in useful time. On the other hand, environmental conditions also play a major role in well-being and can be monitored in real-time to detect and prevent dangerous situations. Both monitored data (physiological and environmental) can be analyzed by doctors in order to support clinical diagnostics. In particular, indoor air quality (IAQ) is a significant factor to be monitored and controlled in real-time for ELEs and occupational health as people typically spend about 90% of their time inside buildings. IAQ assessment supports decision making on possible interventions to improve productivity and a healthy indoor environment by identifying multiple situations or habits that affect well-being. There are several open issues in both the planning and implementation of healthcare systems, such as usability, user interface, data structure, ubiquitous design, ergonomics, and data access [4]. Although there are a number of social and ethical issues, such as acceptance by the users, the privacy and confidentiality of information are already recognized by most healthcare systems [5]. It is likewise imperative to guarantee that technological innovation does not replace human care, and instead it should be used to support medical decisions and monitoring health/diseases anywhere and anytime [6]. By 2050, 20% of the total population will be 60 years old or more [7], and that will bring an increase of healthcare systems' costs and lead to a high dependency on healthcare systems [8]. Likewise, 87% of the general population prefers to stay in their homes instead of moving to a retirement home so they can have better quality of life, and therefore, healthcare systems are also expected to support the high cost of nursing care [9]. IoT architectures refer to the connectivity of physical objects connected to the Internet that support sense capabilities. These objects can be accessed through unique addressing schemes with interaction and cooperation features. IoT architectures incorporate numerous types of devices, such as microcontrollers, sensors, actuators, smartphones, and wearables. Furthermore, open-source platforms, hardware, and enhanced software solutions for data analytics, consulting, management, and storage are required to design and develop IoT architectures.