## 2 Materials and Methods
### Chemistry
13C NMR (DMSO-d6, 100 MHz) & 21.18 (C1-CH3), 55.67 (C2\({}^{\prime\prime}\)-OCH3), 111.83 (C3\({}^{\prime\prime}\)), 120.74 (C5\({}^{\prime\prime}\)), 122.09 (C2\({}^{\prime}\), C6\({}^{\prime}\)), 122.16 (C1\({}^{\prime\prime}\)), 125.50 (C6\({}^{\prime\prime}\)), 128.57 (C4\({}^{\prime}\)), 129.64 (C3, C5), 130.32 (C2, C6), 131.19 (C4), 131.67 (C4\({}^{\prime\prime}\)), 132.42 (C3\({}^{\prime}\), C5\({}^{\prime}\)), 143.55 (N=CH), 146.03 (C1), 151.17 (C1\({}^{\prime}\)), 157.78 (C2\({}^{\prime\prime}\)), 161.76 (C=O). MS (ESI) \(m/z\) calcd. for C22H20N2C5S [M + H]+ 424.11, found 423.96. \(N^{\prime}\)_-[(3-Methoxyphenyl)methylidene)]-4-[(4-methylphenyl)sulfonylylbenzohydrazide_ (**3f**). Yield 96.1%. mp 147.1-147.8 \({}^{\circ}\)C. HPLC tR: 7.106 min, purity: 99.42%. 1H NMR (DMSO-d6, 400 MHz) & 2.42 (s, 3H, C1-CH3), 3.80 (s, 3H, OCH3), 7.00-7.02 (dd, 1H, J1 = 8.0 Hz, J2 = 1.6 Hz, H4\({}^{\prime\prime}\)), 7.19-7.21 (d, 2H, J = 8.8 Hz, H2\({}^{\prime}\), H6\({}^{\prime}\)), 7.27-7.28 (d, 2H, J = 4.0 Hz, H2\({}^{\prime\prime}\), H6\({}^{\prime\prime}\)), 7.35-7.39 (t, 1H, J1 = 8.4 Hz, J2 = 7.6 Hz, H5\({}^{\prime\prime}\)), 7.47-7.49 (d, 2H, J = 8.0 Hz, H2, H6), 7.77-7.79 (d, 2H, J = 8.4 Hz, H3, H5), 7.90-7.92 (d, 2H, J = 8.8 Hz, H3\({}^{\prime}\), H5\({}^{\prime}\)), 8.39 (s, 1H, N=CH), 11.90 (s, 1H, CONH). 13C NMR (DMSO-d6, 100 MHz) & 21.15 (C1-CH3), 55.14 (C3\({}^{\prime\prime}\)), 111.23 (C2\({}^{\prime\prime}\)), 116.30 (C4\({}^{\prime\prime}\)), 120.07 (C6\({}^{\prime\prime}\)), 122.11 (C2\({}^{\prime}\), C6\({}^{\prime}\)), 128.23 (C4\({}^{\prime}\)), 129.65 (C5\({}^{\prime\prime}\)), 130.30 (C2, C6), 131.21 (C4), 132.42 (C3\({}^{\prime}\), C5\({}^{\prime}\)), 135.60 (C1\({}^{\prime\prime}\)), 146.00 (C1), 151.19 (C1\({}^{\prime}\)), 159.53 (C3\({}^{\prime\prime}\)), 162.01 (C=O). MS (ESI) \(m/z\) calcd. for C22H20N205S [M]+ 424.11, found 423.87. \(N^{\prime}\)_-[(4-Methoxyphenyl)methylidene)]-4-[(4-methylphenyl)sulfonylylbenzohydrazide_ (**3g**). Yield 95.1%. mp 172.1-172.8 \({}^{\circ}\)C. HPLC tR: 6.158 min, purity: 99.77%. 1H NMR (DMSO-d6, 400 MHz) & 2.41 (s, 3H, C1-CH3), 3.79 (s, 3H, OCH3), 7.00-7.02 (d, 2H, J = 8.4 Hz, H3\({}^{\prime}\), H5\({}^{\prime}\)), 7.18-7.20 (d, 2H, J = 8.4 Hz, H2\({}^{\prime}\), H6\({}^{\prime}\)), 7.47-7.48 (d, 2H, J = 7.6 Hz, H2, H6), 7.66-7.68 (d, 2H, J = 8.4 Hz, H2\({}^{\prime\prime}\), H6\({}^{\prime\prime}\)), 7.76-7.78 (d, 2H, J = 8.4 Hz, H3, H5), 7.90-7.92 (d, 2H, J = 8.8 Hz, H3\({}^{\prime}\), H5\({}^{\prime}\)), 8.36 (s, 1H, N=CH), 11.77 (s, 1H, CONH). 13C NMR (DMSO-d6, 100 MHz) & 2:1.16 (C1-CH3), 55.26 ((C4\({}^{\prime}\)-OCH3), 114.32 (C3\({}^{\prime\prime}\), C5\({}^{\prime\prime}\)), 122.08 (C2\({}^{\prime}\), C6\({}^{\prime}\)), 126.74 (C1\({}^{\prime\prime}\)), 128.24 (C4\({}^{\prime}\)), 128.75 (C2\({}^{\prime\prime}\), C6\({}^{\prime}\)), 129.58 (C3, C5), 130.30 (C2, C6), 131.23 (C4), 132.62 (C3\({}^{\prime}\), C5\({}^{\prime}\)), 146.00 (C1), 148.02 (N=CH), 151.12 (C1\({}^{\prime}\)), 160.91 (C4\({}^{\prime\prime}\)), 161.83 (C=O). MS (ESI) \(m/z\) calcd. for C22H20N2C5S [M]+ 424.11, found 423.94. \(N^{\prime}\)_-[(2-Bromophenyl)methylidene)]-4-[(4-methylphenyl)]sulfonylylbenzohydrazide_ (**3h**). Yield 99.1%. mp 192.3-193.0 \({}^{\circ}\)C. HPLC tR: 10.518 min, purity: 98.25%. 1H NMR (DMSO-d6, 400 MHz) & 2.40 (s, 3H, C1-CH3), 7.18-7.20 (d, 2H, J = 8.4 Hz, H2\({}^{\prime}\), H6\({}^{\prime}\)), 7.34-7.37 (t, 1H, J = 8.0 Hz, J2 = 7.4 Hz, H4\({}^{\prime\prime}\)), 7.42-7.45 (t, 1H, J = 8.0 Hz, H5\({}^{\prime\prime}\)), 7.45-7.47 (d, 2H, J = 8.0 Hz, H2, H6), 7.65-7.67 (d, 1H, J = 7.2 Hz, H3\({}^{\prime\prime}\)), 7.75-7.77 (d, 2H, J = 8.4 Hz, H3, H5), 7.91-7.93 (d, 2H, J = 9.2 Hz, H3\({}^{\prime}\), H5\({}^{\prime}\)), 7.92-7.99 (d, 1H, J = 7.2 Hz, H6\({}^{\prime\prime}\)), 8.77 (s, 1H, N=CH), 12.12 (s,1H, CONH).