## 5 Discussion
This underlined that all patients in the xerostomia [41] group had a decreased SSF, which was considered an important marked sign in patients with oral cancer after RT treatments [42, 43]. At 3 months, there was a significant reduction in unstimulated (0.346 mL/min) and stimulated (0.80 mL/min) SRF, the unstimulated flow rate continued to decrease further until 6 months (0.295 mL/min), and an increase in SFR (0.91 mL/min) was recorded. After a period of time, 12 months, minimal recovery was detected in both unstimulated (0.362 mL/min) and SFR (1.09 mL/min), facts also revealed by literature confirmation [44, 45]. Despite advances in new RT techniques, patients with oral cancer were registered with oral complications regarding mean stimulated whole salivary flow decreasing from 1.09 to 0.47 mL/min; mean maximal mouth opening, reducing from 45.58 to 42.53 mm at 6 months (at \(p<\) 0.001); and the presence of 8.10% oral mucositis and 3.80% with oral ulceration [46]. Palliative radiation can help relieve symptoms such as pain, swallowing, or breathing problems that can be caused by advanced cancer. These tumors can be treated, even if they spread quickly, to make them smaller, so that the patients can feel better and lead a normal life. Oral diagnostic tools, dedicated to oral health-related quality of life (OH-QO) being reduced [47], can detect changes related to dry mouth, sticky saliva, swallowing solid foods, and sense of taste at 6 months after RT, with resulting negative impacts on oral function and quality of life. Regarding quality of life, it was observed that emotional dimensions were the most affected, and, also, there was a higher number of moderate mucositis correlations with quality of life in association with variables such as pain, saliva, swallowing, and anxiety. Stomatitis, in its various clinical forms, can be found in most systemic diseases (respiratory, metabolic, cardiovascular, hepatic, renal diseases), which alter the local mucosal reactivity. The oral cavity reflects the existence of clinical manifestations caused by systemic risk factors, which can often become their \"primary alarm signal\" or \"primary diagnostic key\" [48]. In this context, after periodontal tissue integration the fixed and mobile prosthetic treatments were applied during the rehabilitation process, obtaining a minimal comfort. Patients in the present study generally had complex pathologies, such as coronal lesions, mixed edentations, periodontal, endodontics, occlusal disorders with a high degree of pathogenicity and a proportional degree of rehabilitation 89.29%, compared to the control group. This was demonstrated by evaluating the mentioned caro- and periodontal indexes and also by the numerous prosthesis applications [49]. Studies present the insufficiency of cohesion forces in situations where the lowest value of adhesion forces was caused by the reduction in salivation, showing that not only the quality but also the amount of saliva secreted was important in adults using mobile prosthetic restorations [50]. Drug support with sialagogue status, cranio-mandibular repositioning, and mental recovery, as well as specific rebalancing treatments, not only in the field of SS, but in the body, with SS being an integral biological system, shows the complexity, and the major impact of management in oral pathology rehabilitation treatments [50], in patients after RT [51]. Radiotherapy significantly improves a patient's chances of survival, and it often coincides with side effects due to the unavoidable co-irradiation of normal tissues surrounding the tumor, which includes salivary glands [52]. Our study had some limitations. The study design was realized with some cases that affected the results' generalization. However, difficulties in participant enrollment existed, as well as unfavorable economic criteria, accompanied by the small number of cases suitable for such research.