## 4 Discussion  
Our study refuted the initial hypothesis that the morphology of the somatosensory cortex would be related to the presence and severity of cutaneous allodynia among patients with different migraine diagnosis. Our study found no association between the thickness and volume of the somatosensory cortex with the allodynia scores and headache clinical \begin{table}
\begin{tabular}{c c c c c} \hline  & **MoA (\(\mathbf{n}\) = 15)** & **MA (\(\mathbf{n}\) = 15)** & **CM (\(\mathbf{n}\) = 15)** & \(\mathbf{p}\) \\ \hline Age (years) & 32.73 (9.70) & 32.73 (8.14) & 33.06 (10.30) & 0.46 \\ BMI (kg/cm\({}^{2}\)) \({}^{1}\) & 24.26 (3.60) & 24.55 (4.47) & 23.15 (2.91) & 0.64 \\ Migraine onset (years) & 15.40 (7.27) & 16.20 (8.25) & 14.13 (10.10) & 0.46 \\ Migraine intensity (NVS) \({}^{2}\) & 7.53 (0.83) & 7.67 (1.63) & 7.67 (1.95) & 0.26 \\ Migraine frequency (days) & 6.80 (2.89) & 8.13 (2.95) & 23.07 (5.82) & 0.04 \\ Aura frequency (days) & - & 4.10 (2.54) & 1.87 (4.07) & 0.06 \\ Thickness (mm) & 2.51 (0.09) & 2.50 (0.09) & 2.49 (0.08) & 0.93 \\ Volume (mm\({}^{3}\)) & 3016.93 (370.87) & 3129.26 (445.36) & 2967.13 (399.74) & 0.98 \\ \hline ASC-12/Brazil & \% (\mu\) & \% (\mu\) & \% (\mu\) & \\ Without allodynia & 13.3 (2) & 0 (0) & 6.7 (1) & \\ With allodynia & 86.6 (13) & 100 (15) & 93.3 (14) & 0.34 \\ Mild allodynia & 15.4 (2) & 13.3 (2) & 28.6 (4) & \\ Moderate allodynia & 46.2 (6) & 33.3 (5) & 28.6 (4) & 0.73 \\ Severe allodynia & 38.5 (5) & 53.3 (8) & 42.9 (6) & \\ \hline \end{tabular} \({}^{\dagger}\) BMI: body mass index, \({}^{2}\) NVS: numeric visual scale.  
\end{table} 
Table 1: Average (SD) and distribution (%, \(n\)) of demographic characteristics, headache features, scores of the allodynia symptom checklist (ASC-12/Brazil), somatosensory cortex volume and thickness of the migraine groups without aura (MoA), with aura (MA) and chronic migraine (CM). \begin{table}
\begin{tabular}{c c c c c} \hline  & **Volume (mm\({}^{3}\))** & **Thickness (mm)** \\ \hline  & r \({}^{1}\) & 95\% CI \({}^{2}\) & r \({}^{1}\) & 95\% CI \({}^{2}\) \\ ASC-12/Brazil & 0.22 & \(-\)0.47 to 0.01 & \(-\)0.16 & \(-\)0.40 to 0.11 \\ Migraine frequency & \(-\)0.14 & \(-\)0.36 to 0.10 & \(-\)0.10 & \(-\)0.34 to 0.15 \\ Migraine onset & \(-\)0.12 & \(-\)0.35 to 0.11 & \(-\)0.06 & \(-\)0.29 to 0.20 \\ Migraine intensity & \(-\)0.11 & \(-\)0.33 to 0.12 & \(-\)0.10 & \(-\)0.39 to 0.19 \\ Aura frequency & \(-\)0.02 & \(-\)0.27 to 0.28 & \(-\)0.20 & \(-\)0.37 to 0.03 \\ \hline \end{tabular} \({}^{\dagger}\) r: [PERSON]’s correlation, \({}^{2}\) 95\% CI: 95\% confidence intervals.  
\end{table} 
Table 2: Correlation between migraine and aura frequency, headache onset, allodynia symptom checklist (ASC-12/Brazil) scores with the thickness and volume of the somatosensory cortex. \begin{table}
\begin{tabular}{c c c c c c} \hline  & **B** & **SE B** & \(\mathbf{\beta}\) & \(\mathbf{p}\) & \(\mathbf{R}^{2}\) & **Adjusted R\({}^{2}\)** \\ \hline Model & - & - & - & 0.08 & 0.04 \\ Constant & 31.58 & 17.40 & - & 0.08 & - & - \\ Volume (mm\({}^{3}\)) & \(-\)0.00 & 0.00 & \(-\)0.21 & 0.17 & - & - \\ Thickness (mm) & \(-\)6.61 & 7.23 & \(-\)0.14 & 0.36 & - & - \\ \hline \end{tabular}
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Table 3: Linear regression model with the scores of the allodynia symptom checklist (ASC-12/Brazil) as dependent variables and the somatosensory cortex thickness and volume as independent variables. features. Furthermore, no differences were verified among migraine subtypes for all assessed outcomes. These results do not agree with previous reports that found a greater thickness of the somatosensory cortex among migraineurs, which correlated to migraine onset and frequency [16]. The authors suggest that the prolonged and repeated attacks would lead to morphologic changes in the areas related to pain processing, including the somatosensory cortex [16].