## 3 Results
### Synthesis
Tert-butyl 3-(([3-acetyl-10-(([3-methacrylamideomopropyl]amino)methyl)anthracen-9-yl]methyl)amino)propanoate (Compound **5**)  
Compound **4** (7.7 g, 0.019 mol) consisted of \(\beta\)-alanine t-butyl ester hydrochloride (12.5 g, 0.069 mol), n-(3-aminopropyl) methacrylate hydrochloride (12.3 g, 0.069 mol), butylated hydroxytoluene (BHT) (0.28 g, 0.00127 mol), and NN-disopropylthymamine (DIPEA) (24 mL, 0.138 mol) in 400 mL of chloroform dissolved at 30 \({}^{\circ}\)C for 18 h. After the solvent was evaporated under reduced pressure, the mixture was washed with distilled water (3 times \(\times\) 200 mL) and dried over MgSO\({}_{4}\). The obtained crude product was purified using silica chromatography with CHCl\({}_{3}\)/MeOH (95:5, \(v/v\)) with the eluent. A yellow powder was obtained (yield: 1.1 g, 15.0%; \({}^{1}\)H NMR (400 MHz, chloroform-d): 8 8.70-7.29(m, 8H), 5.79(s, 1H), 5.72(s, 1H), 4.16(m, 6H), 3.18(d, 2H), 2.94(d, 2H), 2.50(m, 7H), 1.98(s, 3H), 1.74(t, 2H), and 1.42(s, 9H); LC-MS: calculated for C\({}_{32}\)H\({}_{41}\)N\({}_{3}\)O\({}_{4}\)\(m/z\), 531.70; found \(m/z\): 532 [M + H]+). 3.1.6. (2-([(3-Acetyl-10-[((2-borono-5-[trifluoromethylomethyl]benzyl)]-[3-methacrylamideomino)methyl)anthracen-9-yl]methyl)(3-[tert-butoxyl-3-oxopropyl)amino)methyl)-4- (trifluoromethylophenyl)phenyl)boronic Acid (Compound **6**  
Compound **5** (0.2 g, 0.38 mmol) and NN-diisopropylthymamine (DIPEA) (520 mL, 2.97 mmol) in 20 mL of chloroform were stirred at RT. Butylated hydroxytoluene (BHT) (0.01 g, 0.038 mmol), 2-(2-(bromomethyl)-4-(trifluoromethylomethyl)phenyl)-4,4,5,5-tetramethyl-1, and 3,2-dioxoborolane (0.535 g, 1.47 mmol) were added into the reaction mixture, followed by stirring at RT for at least 24 h. After removal of the solvent-reduced pressure, the mixture was dissolved in 20 mL of isopropyl ether and washed 3 times with 20 mL of phosphate buffer (0.2 M, pH 7.0). After removal of the solvent, the product was purified using silica gel chromatography, with CHCl\({}_{3}\)/MeOH (98:2, \(v/v\)) as the eluent. A yellow powder was obtained in a 48.3% yield (0.2 g) (\({}^{1}\)H NMR (400 MHz, chloroform-\(d\)): \(\delta\) 8.70-7.28(m, 14H), 5.79(s, 1H), 4.20(s, 4H), 4.10(s, 2H), 3.76-3.66(m, 6H), 3.18(d, 2H), 2.46(m, 7H), 1.98(s, 3H), 1.73(t, 2H), and 1.42(s, 9H); LC-MS: calculated for C\({}_{48}\)H\({}_{53}\)B\({}_{2}\)F\({}_{6}\)N\({}_{3}\)O\({}_{8}\)\(m/z\): 935.58; found \(m/z\): 936 [M + H]+; 918 [M-H\({}_{2}\)O + H]+ and 900 [M-2H\({}_{2}\)O + H]+). 3.1.7. 3-(((3-Acetyl)-10-(((2-borono-5-(trifluoromethyl)benzyl))(3-methacrylamidopropyl) amino)methyl)anthracen-9-yl)methyl)(2-borono-5-(trifluoromethyl)benzyl)amino)  
Compound 6 (0.2 g, 0.182 mmol) in 5 mL of methylene chloride containing 20 wt% trifluoracetic acid was stirred at room temperature for 20 h. After evaporating the solvent under a vacuum, the product was purified using silica gel chromatography with CHCl\({}_{3}\)/MeOH (95:5, \(v/v\)) as the eluent. A yellow powder was obtained in a 43.5% yield (0.074 g) (\({}^{1}\)H NMR (400 MHz, chloroform-d): \(\delta\) 12.27(s, 1H), 8.70-7.28 (m, 14H), 5.79(s, 1H), 4.20(s, 4H), 4.10(s, 2H), 3.76-3.66(m, 6H), 3.18(d, 2H), 2.46(m, 7H), 1.98(s, 3H), 1.73(t, 2H), and 1.42(s, 9H); LC-MS: calculated for C\({}_{44}\)H\({}_{5}\)B\({}_{2}\)F\({}_{6}\)N\({}_{3}\)O\({}_{8}\)\(m/z\): 879.47; found \(m/z\): 880 [M + H]+; 862 [M-H\({}_{2}\)O + H]+, 844[M-2H\({}_{2}\)O + H]+). 3.1.8. 3-((2-Borono-5-(trifluoromethylomethyl)benzyl)((10-((2-borono-5-(trifluoromethylomethyl)benzyl) (3-methacrylamidopropyl)amino)methyl)anthracen-9-yl)methyl)amino)propanoic acid (Compound 7b)  
After carrying out the same procedure, compound 7b was synthesized through the same steps except for acetylation.