## 3 Results
### Complications  
There were 6630 compilations that occurred in 13,989 early cholecystectomy patients, 1221 compilations that occurred in 5970 intermediate cholecystectomy patients, and 926 compilations that occurred in 3037 delayed cholecystectomy patients.  
The complication rates were 47.93% in the early cholecystectomy group, 20.45% in the intermediate cholecystectomy group, and 30.49% in the delayed cholecystectomy group. There were significant differences (\(p\leq 0.001\)) between the three complication rates in the three groups.  
The complication rates were compared between the early cholecystectomy group and the other two groups. There were significant differences (\(p\leq 0.001\)) in the complication rates between the intermediate cholecystectomy group and the intermediate cholecystectomy group.  
\begin{table}
\begin{tabular}{c c c c c c c c c c c c c} \hline \hline  & **Outcome** & \multicolumn{3}{c}{**Recurrence**} & \multicolumn{3}{c}{**Mortality**} & \multicolumn{3}{c}{**Complications**} \\ \hline \multirow{2}{*}{**Year**} & \multirow{2}{*}{**Variable**} & **Adjusted** & **95\%** & **95\%** & **Adjusted** & **95\%** & **95\%** & **95\%** & **Adjusted** & **95\%** & **95\%** & **P** \\  & & **HR** & **CI** & **CI** & **PR** & **CI** & **CI** & **CI** & **OR** & **CI** & **CI** & **P** \\ \hline \multirow{3}{*}{Overall} & Diagnosis & \multirow{3}{*}{\begin{tabular}{} \end{tabular} } & \multirow{3}{*}{\begin{tabular}{} \end{tabular} } & \multirow{3}{*}{\begin{tabular}{} \end{tabular} } & \multirow{3}{*}{\begin{tabular}{} \end{tabular} } & \multirow{3}{*}{\begin{tabular}{} \end{tabular} } & \multirow{3}{*}{\begin{tabular}{} \end{tabular} } & \multirow{3}{*}{\begin{tabular}{} \end{tabular} } & \multirow{3}{*}{\
\begin{tabular}{} \end{tabular} } & \multirow{3}{*}{
\begin{tabular}{} \end{tabular} } \\  & to LC & & & & & & & & & & & \\  & (months) & & & & & & & & & & & \\  & 0 & Reference & & & & Reference & & & Reference & & & \\  & \(>\)0, \(\leq\)2 & 0.967 & 0.855 & 1.094 & 0.596 & 1.116 & 0.985 & 1.265 & 0.085 & 0.296 & 0.275 & 0.318 & \(<\)0.001 \\  & \(>\)2 & 1.704 & 1.498 & 1.939 & \(<\)0.001 & 1.511 & 1.313 & 1.739 & \(<\)0.001 & 0.487 & 0.446 & 0.513 & \(<\)0.001 \\  & Diagnosis & & & & & & & & & & & \\  & to LC & & & & & & & & & & & \\  & (months) & & & & & & Reference & & & & & & \\  & 0 & Reference & & & & Reference & & & & & & \\  & \(>\)0, \(\leq\)2 & 0.963 & 0.843 & 1.100 & 0.582 & 1.116 & 0.982 & 1.269 & 0.093 & 0.305 & 0.281 & 0.330 & \(<\)0.001 \\  & \(>\)2 & 1.769 & 1.540 & 2.031 & \(<\)0.001 & 1.508 & 1.304 & 1.743 & \(<\)0.001 & 0.504 & 0.457 & 0.555 & \(<\)0.001 \\  & Diagnosis & & & & & & & & & & & \\
2014–2015 & to LC & & & & & & & & & & & & \\  & (months) & & & & & & Reference & & & & & & \\  & 0 & Reference & & & & & & & & & & \\  & \(>\)0, \(\leq\)2 & 0.813 & 0.579 & 1.143 & 0.234 & 0.983 & 0.546 & 1.770 & 0.955 & 0.243 & 0.202 & 0.293 & \(<\)0.001 \\  & \(>\)2 & 1.024 & 0.717 & 1.461 & 0.897 & 1.209 & 0.668 & 2.187 & 0.531 & 0.387 & 0.317 & 0.473 & \(<\)0.001 \\ \hline \hline \end{tabular}
\end{table}
Table 4: Factors associated with the outcomes in the different study periods after using Cox regression, linear regression, and logistic regression.  
group (aHR 0.296, 95% CI 0.275-0.318). There were significant differences (\(p\leq 0.001\)) in the complication rates of the delayed cholecystectomy group (aHR 0.487, 95% CI 0.446-0.513) in the multivariable analysis.  
For the 1998-2013 or 2014-2015 subgroups, the complication rates were significantly different between the early cholecystectomy group and the other two groups, and there were also significant differences (\(p\leq 0.001\)) in the complication rates between the intermediate cholecystectomy group and the delayed cholecystectomy group.