# Differential Proteomic Analysis of _Listeria monocytogenes_ during High-Pressure Processing
## 3 Results
### The Influence of HPP on Differential Expression of L. monocytogenes Proteomes
\begin{table}
\begin{tabular}{c c c c} \hline \hline
**Functional** & & **Upresulation** & **Downregulation** \\ \hline
**Characterization** & & & \\ \hline
**Metabolism (M)** & & & \\ \hline Global and overview maps & 01100 Metabolic pathways & tall\({}^{2}\), adk, tpiA1\({}^{2}\), pdxS\({}^{2}\), luxS, & thrB, hemE, hemA, deoC, \\  & & tari\({}^{2}\), dapF\({}^{1}\) & Alt\({}^{2}\), murE\({}^{2}\), accA\({}^{2}\), gatC, \\  & & atpC\({}^{2}\), gcvH\({}^{2}\), aroD\({}^{2}\), dltC\({}^{2}\) \\ \hline  & 01110 Biosynthesis of secondary & adk, tall\({}^{2}\), tpiA1\({}^{2}\), dapF\({}^{1}\) & thrB, hemE, accA\({}^{2}\), gcvH\({}^{2}\), \\  & metabolites & adk, tall\({}^{2}\), tpiA1\({}^{2}\), dapF\({}^{1}\) & thrB, accA\({}^{2}\), bemA, aroD\({}^{2}\) \\ \hline  & 01120 Microbial metabolism in & \\  & diverse environments & adk, tall\({}^{2}\), tpiA1\({}^{2}\), dapF\({}^{1}\) & thrB, accA\({}^{2}\), hemA \\ \hline  & 01200 Carbon metabolism & tall\({}^{2}\), tpiA1\({}^{2}\) & accA\({}^{2}\), gcvH\({}^{2}\) \\ \hline  & 01230 Biosynthesis of amino acids & tall\({}^{2}\), tpiA1\({}^{2}\), luxS\({}^{2}\), dapF\({}^{1}\) & thrB, aroD\({}^{2}\) \\ \hline Carbohydrate metabolism & 00010 & \\  & Glycolysis/Gluconeogenesis & tpiA1\({}^{2}\) & \\ \hline  & 00030 Pentose phosphate & tall\({}^{2}\) & deoC \\  & pathway & & \\ \hline  & 00040 Pentose and glucuronate & \\  & interconversions & tari\({}^{2}\) & \\ \hline  & 00051 Fructose and mannose & \\  & metabolism & tpiA1\({}^{2}\) & \\ \hline  & 00620 Pyrruvate metabolism & & accA\({}^{2}\) \\ \hline  & 00630 Glyoxylate and & & gcvH\({}^{2}\) \\  & dicarboxylate metabolism & & accA\({}^{2}\) \\ \hline  & 00640 Propanoate metabolism & & accA\({}^{2}\) \\ \hline  & 00562 Inositol phosphate & tpiA1\({}^{2}\) & \\  & metabolism & & \\ \hline Energy metabolism & 00190 Oxidative phosphorylation & & atpC2 \\ \hline  & ko0302 Mitochondrial biogenesis & infC, rpmF\({}^{2}\), rpsP, dnaJ & gatC \\ \hline  & 00195 Photosynthesis & & atpC\({}^{2}\) \\ \hline  & 00710 Carbon fixation in & & \\  & photosynthetic organisms & tpiA1\({}^{2}\) & \\ \hline  & 00720 Carbon fixation pathways & & accA\({}^{2}\) \\  & in prokaryotes & & accA\({}^{2}\) \\ \hline Lipid metabolism & 00061 Fatty acid biosynthesis & & accA\({}^{2}\) \\ \hline Nucleotide metabolism & 00230 Purine metabolism & adk, rpoZ & \\ \hline Amino acid metabolism & 00260 Glycine, serine and & & \\  & threonine metabolism & & thrB, gcvH\({}^{2}\) \\ \hline  & 00270 Cysteine and methionine & & \\  & metabolism & luxS & \\ \hline  & 00300 Lysine biosynthesis & dapF\({}^{1}\) & murE\({}^{2}\) \\ \hline  & 00400 Phenylalanine, tyrosine and & & aroD\({}^{2}\) \\  & tryptophan biosynthesis & & \\ \hline  & ko01002 Peptides and inhibitors & clpP & lexA \\ \hline Glycan biosynthesis & 00473 D-alanine metabolism & & Alr\({}^{2}\), dltC\({}^{2}\) \\ \hline  & 00550 ko01011 PeptideGlycan & & \\  & biosynthesis and degradation & & Alr\({}^{2}\), murE\({}^{2}\), dltC\({}^{2}\) \\  & proteins & & \\ \hline \hline \end{tabular}
\end{table} 
Table 1: KEGG pathway analysis of the DEPs of \(L\). _monocytogenes_ under HPP at 200 and 400 MPa.