## Results  
### Demographic Data and Type D Personality Stratified by the Presence Inflammatory Markers  
Of total patients, 31 (62.0%) had not significant levels of pro-inflammatory markers, 12 (24.0%) had significant CRP levels, and 7 (14.0%) had significant levels of both CRP and IL-6, respectively. The distribution of type D personality depending upon the pro-inflammatory strata has not differed significantly (\(p\) = 0.779) as follows: non-inflammatory strata 45.2%, significant CRP increased level alone 33.3% and both CRP and IL-6 elevated levels 42.9%, respectively (Table 1). Regarding the baseline demographic data, the only significant difference was related to residency, subjects with both elevated pro-inflammatory markers were living more frequent in urban areas (\(p\) = 0.033) compared to the others (Table 1). Depressive Symptoms Profiles Depending upon the Presence of Peripheral Pro-Inflammatory Markers in Major Depressed Patients with Type D Personality. Considering the influence of peripheral pro-inflammatory markers in MDD patients with type D personality, the presence of elevated peripheral pro-inflammatory has been significantly associated with higher somatic anxiety (\(p\) = 0.005) and somatic symptoms-general (\(p\) = 0.016) mean rank scores. \begin{table}
\begin{tabular}{c c c c c} \hline \hline  & \multicolumn{2}{c}{**Without**} & \multicolumn{2}{c}{**With Significant**} & \multicolumn{2}{c}{**With Significant**} \\
**Baseline Demographic Data and** & **Significant** & **CRP Levels,** & **CRP and IL-6** & \(p\)**-Value** \\
**Type D Personality** & **Pro-Inflammatory** & **n = 12** & **Levels, n = 7** & \\ \hline Average current age (SD) a & 49.84 (11.708) & 45.83 (11.519) & 53.00 (13.166) & 0.419 \\ Gender-male, n (\%) b & 7 (22.6\%) & 3 (25.0\%) & 1 (14.3\%) & 0.856 \\ Educational level,mean ranks c & 25.73 & 22.83 & 29.07 & 0.616 \\ Residency-Urban area, n (\%) b & 21 (67.7\%) & 5 (41.7\%) & 7 (100.0\%) & * 0.033 \\ Professional status-Employed or & 12 (38.7\%) & 8 (66.7\%) & 3 (42.9\%) & 0.252 \\ Student, n (\%) b & 22 (71.0\%) & 6 (50.0\%) & 5 (71.4\%) & 0.406 \\ Marital status-with intimate & 14 (45.2\%) & 4 (33.3\%) & 3 (42.9\%) & 0.779 \\ \hline \hline \end{tabular} Note.: *-The level of significance for all analyses was set at \(\alpha\) = 0.05; *-One-Way ANOVA test; b–Chi-Squared test; c—Kruskal Wallis test; TDP–type D personality; CRP—C-reactive protein; IL6—Inteleukin-6; The listed percentages are reported to either strata considered separately.  
\end{table} 
Table 1: Demographic characteristics of the studied group depending on the peripheral elevated pro-inflammatory markersAlthough they did not reach the threshold of statistical significance, it should be noted that most items of the HAM-D scale showed higher mean scores in MDD patients with personality D and proinflammatory markers present compared to their non-inflammatory counterparts. Exceptions were items related to early and middle sleep disorders and weight loss (Table 2). Effect Size of Peripheral Pro-Inflammatory Markers and Type D Personality on the Baseline HAM-D Scores of Studied Subjects  
The significant level of peripheral IL-6 has shown a significant effect of size (\(p\) = 0.023) on the severity of major depression at baseline. Conversely, type D personality has not influenced the severity of depressive symptoms (\(p\) > 0.05) (Table 3).