## 7 Conclusions and Perspectives  
Autologous platelet concentrates were thought to revolutionize both bones and soft tissue regeneration, thus indirectly affecting the quality of life of patients throughout the postoperative recovery period. Therefore, they have found their application in many medical fields, including dentistry [55]. Many authors of clinical studies involving the aforementioned tissue-engineering technologies confirm their efficacy in reducing post-extraction pain and emphasize the anti-inflammatory component of their action, which manifests itself, among other things, in the reduction of trismus and postoperative swelling.  
A number of studies have been conducted to determine the efficacy of A-PRF and CGF in the treatment of edema, pain, and trismus. The therapeutic effect is clearly evident in some publications, but appears to have no significant impact on the recovery process in others. Instead, some studies highlight the lack of benefit associated with the use of the aforementioned approaches, casting doubt on their use.  
In line with the above, the vast majority of publications treating the topic of blood concentrates either state their beneficial effect on the healing of post-extraction wounds or extraction sockets, or indicate that there is no perceived benefit from their use. However, it should be remembered that autologous platelet concentrates are not the panacea of bone healing. PRP, PRGF, A-PRF and CGF, depending on their generation, show differences in the quantitative composition of platelets, leukocytes, growth factors (including TGF-\(\beta\)1, PDGF-BB, VEGF) and pro-inflammatory cytokines (including IL-1B, IL-6) [22]. The amount of the latter increases in the blood of people who have an ongoing inflammatory process or who suffer from systemic diseases such as diabetes. This may result in a prolongation of the inflammatory phase of post-extraction wound healing by increasing the production of local pro-inflammatory cytokines [56]. They result in an imbalance between polarized pro-inflammatory M1 macrophages and inflammation-silencing M2 macrophages in favor of the former. Activated M1 macrophages continuously produce pro-inflammatory cytokines, causing bone resorption through increased osteoclast activity and the inhibition of bone formation by osteoblasts, resulting in impaired and prolonged soft and hard tissue healing [57; 58].  
Unfortunately, there is a lack of studies in the current literature comparing the amount of pro-inflammatory cytokines in a patient's peripheral blood with their levels after centrifugation in blood concentrates. Undoubtedly, more studies are needed to clarify the correlation between pro-inflammatory cytokine levels and alveolar healing after extraction and to assess the risk of treatment with blood concentrates in patients with systemic diseases causing chronic inflammation.  
The tissue-engineering technologies discussed in the article above are relatively new and are constantly being refined by a large number of researchers, necessitating additional clinical trials on large groups of patients to collect more data.  
**Author Contributions:** Conceptualization, M.D.; methodology, M.S. and D.S.; validation, D.S., M.S. and M.D.; formal analysis. P.K.-R. and M.D.; investigation, D.S. and M.S.; writing--original draft preparation, D.S., M.S. and A.P.; writing--review and editing, D.S., M.S., F.M., J.H. and M.D.; supervision, M.D. and J.H.; project administration, M.S. and M.D.; funding acquisition, D.S. and M.D. All authors have read and agreed to the published version of the manuscript.  
**Funding:** The APC was funded by Wroclaw Medical University, grant SIMPLE: STM.B040.20.075.  
**Institutional Review Board Statement:** Not applicable.  
**Informed Consent Statement:** Not applicable.  
**Data Availability Statement:** Available on request.  
**Conflicts of Interest:** The authors declare that they have no conflict of interest.