## Materials and Methods
### Catalytic Investigations  
The catalytic experiments were carried out in a 300 ml high-pressure batch reactor (Parr Instruments Co.) equipped with digital controls for pressure, temperature, and stirring speed. The reaction parameters were monitored and recorded via a 4848B acquisition interface (Parr Instruments Co., (Frankfurt, Germany). Additionally, the reactor was equipped with a preheating unit.  
Prior to the catalytic reaction, the reactor was flushed with hydrogen three times and the catalyst (0.25 g) was reduced in situ overnight under a static atmosphere of 20 bar hydrogen at 250 \({}^{\circ}\)C for 5 h (ramp: 8 \({}^{\circ}\)C min\({}^{-1}\)). After cooling down to room temperature, the reactor was depressurized to 5 bar and preheated to the desired reaction temperature (usually 250 \({}^{\circ}\)C). Simultaneously, the preheating unit was loaded with the reaction solution (containing 0.5 g FAc (24.5 mmol l\({}^{-1}\)) dissolved in 150 ml of cyclohexane and 1 ml of \(n\)-hexadecane as internal standard), flushed three times with hydrogen and also preheated to the desired reaction temperature. The catalytic reaction was then started by charging the preheated reaction solution into the reactor, adjusting the hydrogen pressure to the desired value (usually 100 bar), and setting the desired stirring speed (usually 1000 min\({}^{-1}\)). Subsequently, the first liquid sample was taken (0 min). Additional samples were collected after 10, 30, 60, 90, 120, 180, 240, 360, and 480 min of reaction time.  
These samples were analyzed by gas chromatography (GC) using an Agilent 7890A GC equipped with a flame ionization detector and a HP-5 capillary column (30 m, 0.32 mm i.d., 0.25 \(\upmu\)m film). The GC-mass-spectrometry (MS) based peak identification was based on an earlier work [29] and conducted using a Thermo Scientific ITQ 1100 unit (Thermo Fischer, Waltham, MA, USA). The catalytic results could be reproduced within a standard deviation of \(<\)10%. The calculation of product concentrations was also based on earlier work [29]. Since different furan isomers could not be distinguished by GC-MS and due to the general complexity of the reaction network, in this study all products in which the ring is not yet opened are considered half-hydrogenated (HH) as displayed in Figure 1. In addition to that, the alcohols were also summarized as one product group to simplify the presentation of the results. This grouping of products closely follows the reaction pathway for the HDO of FAc suggested by [PERSON] et al. [30]. The product fractions have been calculated by using the following formula:  
\[z=\frac{\sum_{i=1}^{n}c_{i}}{\sum_{i=1}^{m}c_{i}} \tag{1}\]  
where, \(z\) is the product fraction, \(\sum\limits_{i=1}^{n}c_{i}\) is the sum of the respective concentrations of products associated to the product group, and \(\sum\limits_{i=1}^{m}c_{i}\) is the summed-up concentration of all products observed.  
In case not all isomers could be clearly identified via GC-MS and/or no reference substances were available for calibration, the same response factor was assumed for groups of isomers. Using this method the carbon balance could be closed \(\geq\)95% for reactions with \(n\)-octane product fractions (z\({}_{n\text{-octane}}\)) \(>\) 0.8 and \(\geq\)80% for \(n\)-octane product fractions (z\({}_{n\text{-octane}}\)) \(\leq\) 0.8.