# MScope: A Reliable Battery for Functional Status Assessment in Multiple Sclerosis
## 3 Results
### Inter-Day Reproducibility
\begin{table}
\begin{tabular}{c c c c c c} \hline \multirow{2}{*}{**Tests**} & \multicolumn{2}{c}{**Measures**} & \multirow{2}{*}{**RMs \(p\)-Value**} & \multirow{2}{*}{**ICC (95\% CI)**} & \multirow{2}{*}{**\%CV**} \\ \cline{2-2} \cline{5-6}  & **Day 1** & & & & \\ \hline Handgrip (kg) & 26.84 \(\pm\) 6.2 & 28.18 \(\pm\) 5.9 & 0.031 & 0.817 (0.648–0.905) & 9.2 \\ \hline VLR muscle thickness (cm) & 1.82 \(\pm\) 0.4 & 1.88 \(\pm\) 0.4 & 0.032 & 0.933 (0.875–0.964) & 6.2 \\ \hline VLL muscle thickness (cm) & 1.81 \(\pm\) 0.4 & 1.85\(\pm\) 0.4 & 0.130 & 0.958 (0.920–0.978) & 4.8 \\ \hline RFR muscle thickness (cm) & 1.88 \(\pm\) 0.4 & 1.94 \(\pm\) 0.4 & 0.033 & 0.933 (0.874–0.964) & 5.5 \\ \hline RFL muscle thickness (cm) & 1.85 \(\pm\) 0.4 & 1.88 \(\pm\) 0.4 & 0.028 * & 0.973 (0.948–0.986) & 3.2 \\ \hline TUG test (s) & 5.80 \(\pm\) 0.9 & 5.24 \(\pm\) 0.7 & \textless{}0.001 & 0.866 (0.752–0.927) & 8.6 \\ \hline
60 STST (n) & 33.49 \(\pm\) 10.0 & 38.17 \(\pm\) 10.0 & \textless{}0.001 & 0.937 (0.884–0.966) & 10.8 \\ \hline
5 RSTST (w/kg) & 3.26 \(\pm\) 0.9 & 3.96 \(\pm\) 1.0 & \textless{}0.001 * & 0.832 (0.690–0.909) & 17.8 \\ \hline MVICSQ (N) & 541.79 \(\pm\) 213.0 & 593.18 \(\pm\) 229.0 & 0.014 * & 0.775 (0.587–0.877) & 17.0 \\ \hline GRF (N) & 1196.72 \(\pm\) 276.6 & 1248.35 \(\pm\) 282.4 & 0.102 * & 0.882 (0.682–0.907) & 9.6 \\ \hline GRFR (N) & 604.49 \(\pm\) 152.0 & 628.70 \(\pm\) 156.7 & 0.136 * & 0.850 (0.723–0.919) & 9.6 \\ \hline GRFL (N) & 592.47 \(\pm\) 130.0 & 621.77 \(\pm\) 132.2 & 0.082 & 0.797 (0.625–0.890) & 10.2 \\ \hline MVIC\({}_{\text{LEXT\_R}}\) (N) & 327.87 \(\pm\) 183.9 & 349.23 \(\pm\) 178.9 & 0.067 & 0.955 (0.917–0.975) & 17.1 \\ \hline UMVIELXT\_R (N) & 109.51 \(\pm\) 92.3 & 108.8 \(\pm\) 99.9 & 0.922 & 0.932 (0.875–0.963) & 25.9 \\ \hline UMVIELXT\_L (N) & 122.14 \(\pm\) 96.4 & 122.68 \(\pm\) 94.6 & 0.288 & 0.897 (0.812–0.944) & 26.9 \\ \hline
10 MWT (s) & 5.11 \(\pm\) 0.9 & 4.86 \(\pm\) 0.8 & \textless{}0.001 * & 0.933 (0.875–0.964) & 4.9 \\ \hline
6 MWT (m) & 621.51 \(\pm\) 87.3 & 644.40 \(\pm\) 84.8 & 0.002 & 0.929 (0.866–0.962) & 4.2 \\ \hline \end{tabular}  
* Statistically significant changes between days were assessed using the Student’s \(t\)-test for paired samples unless specified.* Wilcoxon signed-rank test was employed if any data distributions were non-normal. Abbreviations: 5 RSTST, five-repetitions sit-to-stand test; 10 MWT, ten-meter walking test; 60 STST, 60 s sit-to-stand test; cm, centimeters; CI, confidence interval; CV, coefficient of variation; ICC, intraclass correlation coefficient; GRF, peak isometric ground reaction force; GRF\({}_{\text{L}}\), unilateral left peak isometric ground reaction force; GRF\({}_{\text{R}}\), unilateral right peak isometric ground reaction force; kg, kilograms; MVIC\({}_{\text{LEXT}}\), maximal voluntary isometric contraction during the leg extension exercise; MVIC\({}_{\text{SQ}}\), maximal voluntary isometric contraction during the seat exercise; N, newtons; n, number; RF\({}_{\text{L}}\), left rectus femoris; RF\({}_{\text{R}}\), right rectus femoris; s, seconds; RMs, repeated measures; TUG test, timed up–and-go test; UMVICLXT\_L, unilateral left leg extension maximal voluntary isometric contraction; UMVICLXT\_R, unilateral right leg extension maximal voluntary isometric contraction; VL\({}_{\text{L}}\), left vastus lateralis; VL\({}_{\text{R}}\), right vastus lateralis; w/kg, watts per kilogram of body weight.  
\end{table} 
Table 2: Inter-day repeatability of the different evaluated tests. Figure 3: Bland–Altman plots for functional capacity assessments. Figure 2: Bland–Altman plots for muscle mass assessments in vastus lateralis and rectus femoris.