## 1 Introduction  
Cellular processes of postoperative tissue regeneration are negatively affected by antiresorptive drugs, especially in patients with breast cancer, prostate cancer, and multiple myeloma [1, 2]. A serious complication associated with the application of bisphosphonates, monoclonal antibodies, or angiogenesis inhibitors is medication-related osteonecrosis of the jaw (MRONJ). MRONJ is frequently observed after dental surgery and due to denture pressure points [3, 4].  
MRONJ is the progressive destruction of alveolar bone that may remain asymptomatic for years, but may also be associated with pain, ulceration, suppuration, and exposed or sequestered bone [4, 5, 6]. Once MRONJ has developed, complex surgical procedures are frequently required, necessitating prolonged hospitalisation of the patients. Usually, these complicated interventions are a burden on the health care system as well as a psychological burden for patients [7, 8].  
Therefore, in patients treated with these drugs, increased safety precautions must be taken when planning oral surgical interventions. These include perioperative antibiosis and primary wound closure using a muco-periosteal flap [9]. However, since the bone metabolism is affected by bisphosphonates and monoclonal antibodies for a long period of time, the stability of wounds after surgical dental procedures is not guaranteed. Early dehiscence of the wound increases the risk of MRONJ many times over, especially since inflammation and bacterial infection due to bacteria of the oral flora and insufficient oral hygiene can already be a trigger for MRONJ [4; 10].  
In recent years, non-invasive physical plasma (NIPP) has received increased attention with regard to novel therapeutic procedures. The most important effects of NIPP treatment are the highly effective antimicrobial efficacy on a variety of pathogens and the promotion of wound healing. Additionally, NIPP has also been shown to be very effective in devitalizing neoplastic tissue [11; 12; 13; 14; 15]. NIPP corresponds to a highly reactive gas that affects miscellaneous cells and tissues, particularly through reactive oxygen and nitrogen species [16]. Different types of NIPP devices are known in the field of medical applications: dielectric barrier discharges (DBD), plasma jets, as well as hybrid devices that combine both technologies. With DBD devices, NIPP is generated directly at the site of action, with the treated object serving as a counter-electrode. Plasma jets form NIPP inside the device between the cathode and the anode and use a carrier gas to transport NIPP to the place of action [16; 17]. Thus far, the utilization of NIPP in the field of oral and craniomaxillofacial surgery and therapy is not a routine procedure. However, assumingly, NIPP has positive effects on tissue regeneration, due to antimicrobial factors, anti-inflammatory effects and additionally, promotes wound healing.  
This report presents the case of a wound dehiscence associated with zoledronate-therapy for oncological reasons and the benefit of non-invasive treatment with an intraoral certified NIPP device. Additionally, the effect of NIPP on factors associated with wound healing were to be studied using XTT, rtPCR, and scratch assay. Since a healing wound is characterised by a high level of proliferating cells, typically associated proliferation proteins Ki67 and Proliferating Cell Nuclear Antigen (PCNA) [18] should be investigated.