## 3 Results  
Post-CRT changes were found in 32 patients, whereas 5 patients had tumor persistence/recurrence. Results were summarized in Table 1 and Tables S3-S5 in Supplementary Materials. Cohen kappa values showed substantial agreement between the two observers for DWI and DCE-PWI assessments (K values 0.75 to 0.79). ADC\({}_{\text{post}}\) values > 1.33 \(\times\) 10\({}^{-3}\) mm\({}^{2}\)/s, a percentage increase greater than 65.5% in mean ADC\({}_{\text{post}}\) values compared to mean ADC\({}_{\text{pre}}\) values (ADC\({}_{\text{post-pre}}\)%), and values > 0.72 \(\times\) 10\({}^{-3}\) mm\({}^{2}\)/s in the difference between mean ADC\({}_{\text{post}}\) and ADC\({}_{\text{pre}}\) values (ADC\({}_{\text{post-pre}}\)) strongly correlated with post-CRT changes (100% specificity, Figure 1A-C). ADC\({}_{\text{post/muscle post}}\) values > 1.15 and >0.85 showed 96.2% sensitivity and 100% specificity in the detection of post-CRT changes, respectively (Figure 1D). Hypo \begin{table}
\begin{tabular}{c c c c} \hline \hline \multirow{2}{*}{**Magnetic Resonance Feature**} & \multicolumn{2}{c}{**Post-CRT Changes**} & \multicolumn{2}{c}{**Tumor Persistence/Recurrence**} & \multirow{2}{*}{\(p\)**-Value**} \\  & **(32 Patients)** & **(5 Patients)** & **(5 Patients)** & \\  & **Mean \(\pm\) SD (Range)** & **Mean \(\pm\) SD (Range)** & \\ \hline Pre-treatment tumor maximum size (mm) & 18.46 \(\pm\) 7.22 (10.0–40.0) & 20.50 \(\pm\) 9.67 (7.0–30.0) & 0.391 \\ Pre-treatment tumor mean ADC value & 0.82 \(\pm\) 0.15 (0.56–1.14) & 0.89 \(\pm\) 0.08 (0.80–1.0) & 0.245 \\ (\(\times\)10\({}^{-3}\) mm\({}^{2}\)/s) (ADCpre) & 96.76 \(\pm\) 44.15 (44.71–213.73) & 101.61 \(\pm\) 43.21 (55.66–159.70) & 0.746 \\ Pre-treatment tumor mean K(trans) value & 264.80 \(\pm\) 196.75 (61.39–786.30) & 157.44 \(\pm\) 55.02 (113.35–231.28) & 0.498 \\ (\(\times\)10\({}^{-3}\) min) (K(trans)pre) & 0.69 \(\pm\) 0.16 (0.50–1.0) & 0.70 \(\pm\) 0.08 (0.60–0.80) & 0.746 \\ ADCpre & & & \\ AUCpre/trapzius muscle & & & \\ : & 3.70 \(\pm\) 1.50 (1.53–6.73) & 4.07 \(\pm\) 1.23 (3.16–5.89) & 0.536 \\ AUCpre & & & \\ K(trans)pre/trapezius muscle & & & \\ : & 5.62 \(\pm\) 2.96 (1.52–12.92) & 4.73 \(\pm\) 0.38 (4.28–5.23) & 0.702 \\ K(trans)pre & & & \\ Post-treatment residual tissue maximum & & & \\ submucosal enhancement thickness (mm) & 3.31 \(\pm\) 4.13 (0–10.0) & 22.75 \(\pm\) 17.09 (7.0–45.0) & 0.002 \\ Post-treatment residual tissue mean ADC value & & & \\ (\(\times\)10\({}^{-3}\) mm\({}^{2}\)/s) (ADCpost) & 1.54 \(\pm\) 0.23 (0.96–1.96) & 1.05 \(\pm\) 0.26 (0.78–1.32) & 0.002 \\ Post-treatment residual tissue mean AUC value & & & \\ (AUCpost) & 105.10 \(\pm\) 51.14 (35.37–260.88) & 123.62 \(\pm\) 49.26 (59.77–162.90) & 0.425 \\ Post-treatment tumor mean K(trans) value & & & \\ (\(\times\)10\({}^{-3}\) min) (K(trans)pre) & 181.80 \(\pm\) 201.80 (25,54–787.92) & 142.42 \(\pm\) 67.63 (56.24–215.45) & 0.659 \\ ADCpost/trapezius muscle & & & \\ : & 1.24 \(\pm\) 0.18 (0.80–1.50) & 0.87 \(\pm\) 0.15 (0.8–1.10) & 0.002 \\ ADCpost & & & \\ AUCpost/trapezius muscle & & & \\ : & 3.55 \(\pm\) 1.24 (1.13–6.07) & 4.34 \(\pm\) 0.82 (3.52–5.43) & 0.177 \\ AUCpost & & & \\ K(trans)post/trapezius muscle & & & \\ : & 5.15 \(\pm\) 4.57 (1.17–23.07) & 4.86 \(\pm\) 0.65 (4.08–5.41) & 0.359 \\ K(trans)post & & & \\ ADCpost-pre & 0.70 \(\pm\) 0.26 (0.16–1.20) & 0.26 \(\pm\) 0.40 (\(-\)0.13–0.70) & 0.052 \\ ADCpost-pre\% & 92.12 \(\pm\) 44.10 (21.0–209.0) & 20.75 \(\pm\) 36.48 (\(-\)13.0–65.0) & 0.005 \\ AUCpost/pre & 1.26 \(\pm\) 0.79 (0.40–3.70) & 1.24 \(\pm\) 0.37 (1.01–1.80) & 0.659 \\ AUCpost/pre/trapezius muscle & 1.08 \(\pm\) 0.11 (0.37–2.70) & 1.09 \(\pm\) 0.57 (0.92–1.18) & 0.791 \\ K(trans)post/pre & 1.06 \(\pm\) 1.41 (0.06–5.66) & 0.96 \(\pm\) 0.63 (0.48–1.90) & 0.498 \\ K(trans)post/pre/trapezius muscle & 1.07 \(\pm\) 0.91 (0.30–4.01) & 1.02 \(\pm\) 0.11 (0.86–1.14) & 0.271 \\ \hline \hline \end{tabular}
\end{table} 
Table 1: Mean, standard deviation, and range values of the post-chemoradiotherapy tissue changes and tumor persistence/recurrence. CRT: chemoradiotherapy.