## Appendix A
There is no isoform listed for the genes in Table 14.  
Very few enzymes involved in the biosynthesis of cannabisativine and anhydrocannabisativine are known or available, with the exception of polyamine biosynthesis genes. Table 15 shows the gene for an enzyme that adds a myristoyl group to a glycine at the N-terminus of a protein, possibly capable of catalyzing the condensation reaction between a spermidine molecule and a myristic acid. Polyamine biosynthesis genes are well-conserved across species and are therefore easily characterized. Table 15 shows all the genes required for spermine and spermidine biosynthesis. \begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Enzyme** & **Name** & **Gene ID** & **Chromosome** & **mRNA** & **Protein** \\ \hline \multirow{3}{*}{Phenylalanine ammonia-lyase} & PAL & LOC115706668 & 1 & XM\_030634382.2 & XP\_030490242.2 \\ \cline{2-6}  & \multirow{3}{*}{PAL} & LOC115709862 & 3 & XM\_030638093.2 & XP\_030493953.1 \\ \cline{3-6}  & & LOC115709383 & 3 & XM\_030637471.2 & XP\_030493331.2 \\ \hline \multirow{3}{*}{Cinnamate 4-hydroxyylase} & C4H & LOC115719463 & 2 & XM\_030648524.2 & XP\_030504384.1 \\ \cline{2-6}  & CYP73A100 & LOC115709609 & 3 & XM\_030637745.2 & XP\_030493605.2 \\ \hline \multirow{3}{*}{4-Cumarate-CoA ligase} & 4 CL1 & LOC115699364 & 8 & XM\_030626724.2 & XP\_030482584.2 \\ \cline{2-6}  & 4 CL2 & LOC115717276 & 5 & XM\_030646244.2 & XP\_030502104.2 \\ \cline{2-6}  & \multirow{3}{*}{CCL1} & LOC115694777 & 6 & XM\_061116895.1 & XP\_060972878.1 \\ \cline{3-6}  & & & XM\_030621866.2 & XP\_030477726.2 \\ \hline \multirow{3}{*}{Caffeoyl-CoA-O- methyltransferase} & \multirow{3}{*}{CCOMT} & LOC115702947 & X & XM\_030630419.2 & XP\_030486279.1 \\ \cline{3-6}  & & LOC115716906 & 5 & XM\_030645827.2 & XP\_030501687.2 \\ \cline{3-6}  & & LOC115716367 & & XM\_030645149.2 & XP\_030501009.2 \\ \cline{3-6}  & & LOC115697697 & 7 & XM\_030624792.2 & XP\_030480652.2 \\ \cline{3-6}  & & LOC115721930 & 9 & XM\_030651036.2 & XP\_030506896.2 \\ \cline{3-6}  & & LOC115723302 & 9 & XM\_030652742.2 & XP\_030508602.2 \\ \hline \multirow{3}{*}{Tyrosine decarboxylase} & \multirow{3}{*}{TYDC} & LOC115696858 & 7 & XM\_030623740.2 & XP\_030479600.1 \\ \cline{3-6}  & & LOC115721923 & 9 & XM\_030651029.2 & XP\_030506889.2 \\ \cline{2-6}  & & TYDC1 & LOC115721880 & 9 & XM\_061105012.1 & XP\_060960995.1 \\ \hline \multirow{3}{*}{Spermidine hydroxycinnamoyl transferase} & \multirow{3}{*}{SHCT} & LOC115716016 & 5 & XM\_030644703.2 & XP\_030500563.2 \\ \cline{3-6}  & & LOC115695248 & 6 & XM\_030622328.2 & XP\_030478188.2 \\ \cline{3-6}  & & LOC115696820 & 7 & XM\_030623703.2 & XP\_030479563.2 \\ \hline \multirow{3}{*}{Spermidine hydroxycinnamoyl transferase} & \multirow{3}{*}{SHCT-L} & LOC115712649 & 4 & XM\_030640956.2 & XP\_030496816.2 \\ \cline{3-6}  & & LOC115716993 & \multirow{3}{*}{5} & XM\_030645919.2 & XP\_030501779.2 \\ \cline{3-6}  & & LOC115716541 & & XM\_030645353.2 & XP\_030501213.2 \\ \hline \multirow{3}{*}{Hydroxycinnamoyl transferase} & \multirow{3}{*}{HCT} & LOC115721023 & 2 & XM\_030650250.2 & XP\_030506110.2 \\ \hline \hline \end{tabular}
\end{table} 
Table 14: Listed _Cannabis_ genes found on NCBI involved in the phenylpropanol pathway and in the biosynthesis of cinnamic acids and their amides.