# Acute and Repeated Toxicological Study of Anti-Inflammatory Herbal Formula, Yeosinsan, in Rats
## 3 Results
### Chronic oral Toxicity
#### 3.2.4 Hematological Test
**\(p\) < 0.01 according to  
\begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Dosage Group (mg\(\cdot\)kg\({}^{-1}\).d\({}^{-1}\))** & **0** & **500** & **1000** & **2000** \\ \hline RBC (\(\times 10^{6}\)/\(\mu\)L) & 9.06 \(\pm\) 0.626 & 8.70 \(\pm\) 0.371 & 8.40 \(\pm\) 0.337 ** & 8.21 \(\pm\) 0.347 ** \\ HGB (g/dL) & 15.6 \(\pm\) 0.54 & 15.3 \(\pm\) 0.37 & 15.1 \(\pm\) 0.53 & 15.2 \(\pm\) 0.41 \\ HCT (\%) & 50.8 \(\pm\) 1.96 & 49.7 \(\pm\) 1.23 & 48.9 \(\pm\) 2.14 & 49.2 \(\pm\) 1.61 \\ MCV (fL) & 56.2 \(\pm\) 2.71 & 57.2 \(\pm\) 2.2 & 58.3 \(\pm\) 1.78 & 60.0 \(\pm\) 2.14 ** \\ MCH (pg) & 17.4 \(\pm\) 1.06 & 17.7 \(\pm\) 0.8 & 17.9 \(\pm\) 0.55 & 18.6 \(\pm\) 0.65 ** \\ MCHC (g/dL) & 30.8 \(\pm\) 0.68 & 30.9 \(\pm\) 0.56 & 30.8 \(\pm\) 0.5 & 30.9 \(\pm\) 0.47 \\ RET\% (\%) & 2.03 \(\pm\) 0.453 & 2.25 \(\pm\) 0.412 & 2.76 \(\pm\) 0.366 ** & 3.21 \(\pm\) 0.352 ** \\ RETA (\(\times 10^{9}\)/uL) & 181.9 \(\pm\) 30.02 & 194.1 \(\pm\) 28.71 & 231.5 \(\pm\) 27.26 ** & 263.5 \(\pm\) 27.76 ** \\ PLT (\(\times 10^{5}\)/uL) & 884.8 \(\pm\) 241.68 & 996.4 \(\pm\) 95.96 & 1036.3 \(\pm\) 148.98 & 989.3 \(\pm\) 219.31 \\ NEU\% (\%) & 14.9 \(\pm\) 5.49 & 16.5 \(\pm\) 5.01 & 14.7 \(\pm\) 4.78 & 16.1 \(\pm\) 5.57 \\ LYM\% (\%) & 79.7 \(\pm\) 5.7 & 78.2 \(\pm\) 5.45 & 80.5 \(\pm\) 4.35 & 78.6 \(\pm\) 6.26 \\ EOS\% (\%) & 1.2 \(\pm\) 0.49 & 1.3 \(\pm\) 0.22 & 1.1 \(\pm\) 0.28 & 1 \(\pm\) 0.37 \\ MON (\%) & 2.7 \(\pm\) 0.76 & 2.4 \(\pm\) 0.77 & 2.4 \(\pm\) 0.95 & 2.5 \(\pm\) 0.85 \\ BAS\% (\%) & 0.4 \(\pm\) 0.09 & 0.4 \(\pm\) 0.11 & 0.4 \(\pm\) 0.13 & 0.5 \(\pm\) 0.15 \\ LUC\% (\%) & 1.1 \(\pm\) 0.6 & 1.3 \(\pm\) 0.65 & 1 \(\pm\) 0.4 & 1.3 \(\pm\) 0.67 \\ WBC (\(\times 10^{3}\)/uL) & 11.95 \(\pm\) 2.923 & 10.76 \(\pm\) 2.25 & 9.23 \(\pm\) 1.877 & 10.35 \(\pm\) 2.063 \\ NEUA (\(\times 10^{3}\)/uL) & 1.76 \(\pm\) 0.75 & 1.79 \(\pm\) 0.695 & 1.32 \(\pm\) 0.372 & 1.68 \(\pm\) 0.801 \\ LYMA (\(\times 10^{3}\)/uL) & 9.55 \(\pm\) 2.582 & 8.39 \(\pm\) 1.67 & 7.47 \(\pm\) 1.768 & 8.11 \(\pm\) 1.524 \\ MONA (\(\times 10^{3}\)/uL) & 0.32 \(\pm\) 0.107 & 0.26 \(\pm\) 0.119 & 0.22 \(\pm\) 0.085 & 0.26 \(\pm\) 0.135 \\ EOSA (\(\times 10^{3}\)/uL) & 0.14 \(\pm\) 0.054 & 0.14 \(\pm\) 0.047 & 0.1 \(\pm\) 0.036 & 0.1 \(\pm\) 0.04 \\ BASA (\(\times 10^{3}\)/uL) & 0.05 \(\pm\) 0.012 & 0.05 \(\pm\) 0.016 & 0.04 \(\pm\) 0.016 & 0.05 \(\pm\) 0.016 \\ LUCA (\(\times 10^{3}\)/uL) & 0.14 \(\pm\) 0.089 & 0.15 \(\pm\) 0.111 & 0.09 \(\pm\) 0.043 & 0.14 \(\pm\) 0.104 \\ \hline RBC (\(\times 10^{5}\)/uL) & 8.23 \(\pm\) 0.355 & 7.91 \(\pm\) 0.236 * & 7.91 \(\pm\) 0.285 * & 7.44 \(\pm\) 0.277 ** \\ HGB (g/dL) & 15.5 \(\pm\) 0.56 & 15.2 \(\pm\) 0.61 & 15.1 \(\pm\) 0.70 & 14.8 \(\pm\) 0.39 \\ HCT (\%) & 49.2 \(\pm\) 1.61 & 47.5 \(\pm\) 1.68 & 47.9 \(\pm\) 2.43 & 46.2 \(\pm\) 1.07 ** \\ MCV (fL) & 59.8 \(\pm\) 1.38 & 60.0 \(\pm\) 1.04 & 60.5 \(\pm\) 1.75 & 62.1 \(\pm\) 0.96 ** \\ MCH (pg) & 18.9 \(\pm\) 0.36 & 19.2 \(\pm\) 0.46 & 19.0 \(\pm\) 0.57 & 19.9 \(\pm\) 0.33 ** \\ MCHC (g/dL) & 31.5 \(\pm\) 0.46 & 31.9 \(\pm\) 0.67 & 31.5 \(\pm\) 0.42 & 32.1 \(\pm\) 0.32 * \\ RET\% (\%) & 2.10 \(\pm\) 0.367 & 2.73 \(\pm\) 0.296 ** & 3.27 \(\pm\) 0.375 ** & 2.98 \(\pm\) 0.486 ** \\ RETA (\(\times 10^{9}\)/uL) & 173.3 \(\pm\) 30.99 & 216.1 \(\pm\) 23.02 ** & 258.9 \(\pm\) 34.10 ** & 220.9 \(\pm\) 33.50 ** \\ PLT (\(\times 10^{5}\)/uL) & 996.1 \(\pm\) 96.69 & 1052.1 \(\pm\) 105.30 & 1074.4 \(\pm\) 78.18 & 1087.1 \(\pm\) 137.76 \\ NEU\% (\%) & 11.4 \(\pm\) 5.63 & 12.8 \(\pm\) 2.93 & 12.7 \(\pm\) 5.93 & 12.3 \(\pm\) 4.25 \\ LYM\% (\%) & 83.4 \(\pm\) 5.78 & 81.1 \(\pm\) 4.41 & 82.1 \(\pm\) 6.21 & 82.8 \(\pm\) 4.90 \\ EOS\% (\%) & 1.3 \(\pm\) 0.39 & 1.4 \(\pm\) 0.55 & 1.1 \(\pm\) 0.26 & 1.1 \(\pm\) 0.52 \\ MON (\%) & 2.4 \(\pm\) 0.88 & 2.9 \(\pm\) 1.32 & 2.3 \(\pm\) 0.57 & 2.1 \(\pm\) 0.60 \\ BAS\% (\%) & 0.4 \(\pm\) 0.15 & 0.5 \(\pm\) 0.16 & 0.6 \(\pm\) 0.21 & 0.5 \(\pm\) 0.32 \\ LUC\% (\%) & 1.1 \(\pm\) 0.41 & 1.4 \(\pm\) 0.59 & 1.2 \(\pm\) 0.24 & 1.3 \(\pm\) 0.53 \\ WBC (\(\times 10^{3}\)/uL) & 7.82 \(\pm\) 2.014 & 7.