# Modifications of Wound Dressings with Bioactive Agents to Achieve Improved Pro-Healing Properties
## 3 Pro-Healing Wound Dressings
### The Effect of Natural Compounds on Skin Regeneration
#### 3.1.1 Curcumin-Loaded Biomaterials
aureus_) & Initial burst release of curcumin [53] \\  & Curcumin & In vitro (L929—mouse cavarial preosteoblasts cell line) & Anticancer properties & Initial burst release of curcumin [53] \\  & Curcumin & In vitro (L929—mouse cavarial preosteoblasts cell line) & Anticancer properties & Initial burst release of curcumin [53] \\  & Curcumin & In vitro (L929—mouse cavarial preosteoblasts cell line) & Anticancer properties & Initial burst release of curcumin [53] \\  & Curcumin & In vitro (L929—mouse cavarial preosteoblasts cell line) & Anticancer properties & Initial burst release of curcumin [53] \\  & Curcumin & In vitro (L929—mouse cavarial preosteoblasts cell line) & Anticancer properties & Initial burst release of curcumin [53] \\  & Curcumin & In vitro (L929—mouse cavarial preosteoblasts cell line) & Anticancer properties & Initial burst release of curcumin [53] \\  & Curcumin & In vitro (L929—mouse cavarial preosteoblasts cell line) & Anticancer antibacterial activity (_E.coli_, _S. aureus_) & Initial burst release of curcumin [53] \\  & Curcumin & In vitro (L929—mouse cavarial preosteoblasts cell line) &  
[PERSON] et al. [59] performed studies on the modification of curcumin-loaded biomaterial by quaternization of chitosan. As a result of the introduced changes, the water solubility of the biomaterial increased. Modified film revealed better mechanical properties and a higher curcumin release profile (higher antioxidant activity). However, it also contributed to lower biomaterial swelling properties. [PERSON] et al. [60] developed biomaterial through the incorporation of curcumin within a hydrogel system. The TEMPO-oxidized cellulose nanofiber-PVA-Cur hydrogel supported wound contraction and provided faster wound closure in a rat model compared to the control group. Furthermore, it was revealed that tested biomaterials loaded with curcumin enhanced collagen accumulation. [PERSON] et al. [61] demonstrated that curcumin coating on the cotton gauze improved the properties of the resultant wound dressing. A spin-coating technique was used to prepare curcumin nanocomposite on a cotton cloth. The introduced modification improved the average drying time and absorption capacity of the produced nanocomposite. In turn, [PERSON] et al. [53] showed enhanced antibacterial activity (_E. coli_ and _S. aureus_) of the curcumin-loaded nanocomposite. Obtained PCL/quaternary ammonium salt-modified montmorillonite/curcumin nanocomposites exhibited low cytotoxicity and showed great potential for infected wound management. Interestingly, curcumin was also demonstrated to have promising anticancer activity. [PERSON] et al. [62] proved a high inhibitory effect of the curcumin-loaded cellulose-halloysite nanotube hydrogel on human breast cancer cells (MCF-7 cell line) in vitro. Thus, it may be assumed that curcumin-loaded biomaterials may be potentially promising wound dressings for the management of the wound after skin cancer excision. Based on presented scientific reports, it can be concluded that numerous of the biomaterial key features may be improved by the incorporation of curcumin component. Importantly, addition of curcumin not only may provide antibacterial properties of the dressing but also it can improve cell proliferation and growth or could even be used for anticancer treatment [55; 59; 63; 64]. Moreover, curcumin-loaded biomaterials may reveal improved mechanical and physicochemical properties. Nevertheless, the concentration and composition of the biomaterial must be chosen reasonably to overcome the limitations that can appear after dressing productions (e.g., too fragile structure).