## 3 Chemical Composition of _Hyssopus officinalis_ L. and _Agastache foeniculum_ (Pursh) Kuntze EOs
### Chemical Composition of Hyssopus officinalis L. EO  
The effective quality control of _H. officinalis_ EO is based on the identification of plant samples at the intraspecific level and subjected to a precise chemical analysis. The _H. officinalis_ EO international standard (ISO 9841:2013) [35] provides 13 compounds as representative and characteristic, where pinocamphone, isopinocamphone, and pinene are the most significant. The volatile compounds of _H. officinalis_ L. EO are listed in detail in Table 3. The _H. officinalis_ EO constituents are categorized as oxygenated monoterpenes (27.32-92.25%) [21], monoterpene hydrocarbons (3.84-67.24%) [21], sesquiterpene hydrocarbons (0.64-28.31%) [23; 37], and oxygenated sesquiterpenenes (0-21.08%) [37]. Figure 2 presents the distribution of these classes. \begin{table}
\begin{tabular}{c c c c c c c} \hline \hline
**Method of** & **Part of the** **Plant Used** & **Stage of the Plant** **at Harvest** & **Mass of the Plant Material Used for Extraction** & **Yield** & **Origin of the Plant** & **Reference** \\ \hline Hydrodistillation & & & & & & \\ with a & Stem, leaves, and & & & & & \\ Clevenger-type & flowers & Flowering & 50 g & 1.86 \(\pm\) 0.64\% (\(r/w\)) & Romania & [16]\({}^{1}\) \\ apparatus & & & & & & \\ \hline Hydrodistillation & & & & & & \\ with a & Aerial parts & Flowering & 25 g & NM & Iran & [40] \\ Apparatus & & & & & & \\ \hline Hydrodistilled & & & & & & \\ using & & & & & & \\ a Likens–Nickerson apparatus with extraction with dichloromethane & & & & & & \\ \hline Hydrodistillation & & & & & & \\ with a & & & & & & \\ Clevenger-type & & & & & & \\ apparatus & & & & & & \\ \hline Hydrodistillation & & & & & & \\ using a & & & & & & \\ Neo-Clevenger type & & & & & & \\ apparatus & & & & & & \\ \hline Hydrodistillation & & & & & & \\ using a & & & & & & \\ Neo-Clevenger type & & & & & & \\ apparatus & & & & & & \\ \hline Hydrodistillation & & & & & & \\ using a & & & & & & \\ Neo-Clevenger type & & & & & & \\ apparatus & & & & & & \\ \hline Hydrodistillation & & & & & & \\ with a & & & & & & \\ Clevenger-type & & & & & & \\ apparatus & & & & & & \\ \hline \hline \end{tabular}
\end{table} 
Table 2: _Cont._  
\begin{table}
\begin{tabular}{c c c c c c c} Total Number of & Total & Min Classes & Min Compounds & Min Compounds & Reference \\ Identified & Compounds & Compounds & (C) & (C) & (C) \\ \hline \multicolumn{1}{c}{} & & & & \\  & & & & &  
\begin{table}
\begin{tabular}{c c c c c} \hline
**Total Number of** & **Total** & **Min Cases** & **Min Cases** & **Min Compounds** & **Reference** \\
**Identified** & **Journal** & **of Compounds** & **of Compounds** & **of Compounds** \\
**Compounds** & **Co** & **(**)** & **(**)** & **(**)** \\ \hline \multicolumn{5}{c}{**Ospensed temperatures: 100T,94K, 102C, 41.7, KO3**} & **14-Chemical GO1**: 60T, 60E, 597.70, KO3**: 12C, 868.13, 160.66, 606.06 \\  & & & **of-Mn**:**  
\begin{table}
\begin{tabular}{c c c c c c} \hline \hline Total Number of & \multicolumn{1}{c}{Total} & \multicolumn{1}{c}{Mass Causes} & \multicolumn{1}{c}{Mass Causes} & \multicolumn{1}{c}{Mass Compounds} & \multicolumn{1}{c}{References} \\  
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\begin{tabular}{c c c c c c} Total Number of & Total & Main Classes & Main Compounds & Reference \\ Modified & Modified & of Compounds & Ed & Ed \\ Compounds & (e) & (e) & & \\ \end{tabular}
\end{table} 
Table 3: Cont. The preponderance of the oxygenated monoterepenes in the oil composition is reflected in its major constituents: 1,8-cineole, isopinocamphone, and pinocamphone. This class is completed by linaloal, myrtenol, and borneol, among others. The prominent monoterepene hydrocarbons were \(\beta\)-pinene, \(\beta\)-phellandrene, and \(\beta\)-ocimene, but \(\alpha\)-pinene, sabinene, myrcene, and limonene can also be found. The main sesquiterpene hydrocarbons found in _H. officinalis_ EO are \(\beta\)-caryophyllene, germacrene D, bicyclogermacrene, and alloaromadetrene.