# Plant-Origin Additives from _Boswellia_ Species in Emulgel Formulation for Radiotherapy Skin Care
###### Abstract  
The research objective of this study was to include plant-origin additives of the _Boswellia_ species in the formulation of topical preparations for skin care after radiotherapy. The main factor damaging the skin during radiotherapy is the free radicals that form from water molecules and granulocytes in the inflammatory area; hence, the use of substances with antioxidant properties, including plant extracts rich in antioxidants, seems to be an alternative therapy in radiodermatitis treatment. A series of cosmetic preparations containing plant-origin additives from _Boswellia_ species and corresponding placebo formulations were prepared. In order to assess the applicability of emulgels as oncocosmetics, their stability, physicochemical properties, rheological properties, and antioxidant capacity were determined. Somatosensory analysis was also performed. An attempt was also made to correlate the effect of plant-derived additives on the functional properties of the product determined via instrumental methods and the sensory properties. The most promising preparation was the emulel containing the Soxblet extract and essential oil (Em_SO) due to its high antioxidant properties compared to other preparations (% inhibition of 11.69) and polyphenol content (3.63 mg/d m\({}^{3}\)). Additionally, probably positively assessed all its features, including consistency (4.00), absorption (4.43), and hydration (4.71). The presence of significant correlations for % inhibition and polyphenols content with sensory and physicochemical characteristics of samples was indicated. There were low ratings for placebo preparations by probands, and the demonstrated correlations of odor with moisturization and distribution, oiliness and hydration with the % inhibition of the sample, and the content of polyphenols with the pH and size of the dispersed phase droplets proved the positive effect of the addition of plant-origin additives from _Boswellia_ to the emulgel formulation on the functional and sensory properties. emulgels; radiotherapy skin care; _Boswellia_ species; antioxidant properties +
Footnote †: journal: _Sciences_  
0000-0001-9900-0001-9900][PERSON] 0000-0001-9900-0001-9900][PERSON] 0000-0001-9900-9001-9900-99001-9900-99001-99001-99001-99001-99001-99001-99001-99001-99001-99001-99001-99001-99001-99001-9001-99001-99001-9001-99001-9001-99001-9001-9001-9001-9001-9001-9 Among the most common types of side effects of therapy affecting approximately 95% of patients are skin reactions--radiodermatitis [2; 5]. These skin manifestations range from slight to severe skin damage. The most vulnerable areas are those parts of the body where two skin surfaces meet (breasts, crouch), those with thin and smooth skin (crouch, face, armpits), and areas of skin where the integrity of the skin layers has already been compromised [2]. The skin reactions observed during treatment depend both on the radiation dose and duration of treatment but also on comorbidities, age, general health, addictions, and other drugs used [2; 6]. The most common skin reactions include transient and persistent erythema, moist and dry desquamation accompanied by serous effusion, persistent epilation, hyperpigmentation, ulceration, spots and/or rash, skin atrophy, and others [2; 7; 8; 9]. Radiodermatitis also causes burning, pain, and discomfort among patients [2; 8; 9]. This decreases the quality of patients' lives, causing pain, treatment delay, or aesthetic defects. Radiotherapy causes damage to Langerhans cells, basal cells, and the vascular endothelium. The decreased number of Langerhans cells and the depletion of basal layer stem cells lead to impaired barrier and immune function, increasing the risk of wound infection. Damage to vasculature can induce hypoxia and TGF-\(\beta\) production, further driving fibrosis. Tissue hypoxia with associated necrosis and inflammation can lead to the generation of significant amounts of reactive oxygen species (ROS).