The development of a nanoemulsion concurrently achieved improvements in substance stability, greater surface area for enhanced cellular administration, and an enhanced bioavailability and biodistribution of molecules [105]. Silver nanoparticles with the self-assembling GL13K peptide were also used as a nanocoating material for enhanced osseointegration in titanium mini implants [106]. The DK5 peptide was also evaluated, which was derived from histatin-1 and further encapsulated into a liposomal delivery system (DK5-Lips) for remineralization of initial enamel caries. Researchers confirmed both in vitro and in vivo that DK5-Lips displayed a favorable slow-release effect of the peptides. Simultaneously, such developed nanoliposomes also demonstrated good stability in saliva, while promoting a higher amount of remineralization and reducing the extent of tooth decay [76]. Significantly fewer recent literature reports have addressed the use of natural AMPs and their synthetic analogs in treating head and neck cancers, including oral cancers. Among those presented, piscidin-1, an AMP derived from the mast cells of hybrid striped bass (_Morone saxatilis_\(\times\)_M. chrysops_), in addition to its antibacterial properties, induces ROS-mediated apoptosis in oral squamous cell cancer cells and inhibits the angiogenesis, demonstrating the ability to limit cancer spreading by both direct and indirect mechanisms [107; 108]. A unique advantage in the treatment of periodontal diseases has recently been attributed to the development of nanofibrous membranes with antibacterial, anti-inflammatory, and tissue regenerative properties, prepared by electrospinning. To date, a compelling number of reports demonstrate the great clinical potential of electrospinning-prepared biomaterials for wound dressings [109], cancer treatment [110], and tissue engineering [111]. The extensive range of medical applications, including dentistry, is attributable to the distinctive properties of these biomaterials, which include (i) their capacity to replicate the scale and morphology of extracellular matrix (ECM) proteins, thereby promoting cell attachment, proliferation, and differentiation, (ii) high porosity that permits oxygen permeation, and (iii) the ability to enhance drug loading and ensure localized, sustained, and controlled drug delivery [112; 113]. Although a majority of reports on the antimicrobial properties of electrospun biomaterials engage conventional antibiotics [114], polymers [115], or nanoparticles [116] as factors limiting the spreading of infection, there are also a few studies demonstrating that such prepared biomaterials might be incorporated with AMPs. In one report, LL-37 and plant-derived polyphenol were used to modify nanofibrous scaffolds to obtain a material with antimicrobial features, anti-inflammatory effects, and the ability to promote bone regeneration [117]. Similarly, lysozyme was integrated into a uncoadhesive electrospun patch, creating a drug delivery system with significant promise for administering therapeutic proteins to the oral mucosa [118]. In another study, Pac-525, a short, tryptophan-rich AMP with antimicrobial activity against _S. sanguis_, _F. nucleatum_, and _P. gingivalis_, was released over extended periods from nanofibrous membranes, inhibiting bacterial infections for up to one month while accelerating bone regeneration [119]. These studies encourage continued research on the creation of AMP-containing electrospun biomaterials, despite the numerous hurdles that remain in attaining clinical treatment for patients. Collectively, cited reports suggest that AMPs have significant application potential in the treatment of oral disorders, which is related to their multidirectional antimicrobial activity, including not only direct lethal effects but also indirect effects such as the induction of phagocytosis processes. Thus, further research into the modification of AMPs to improve their stability, biological activity, or biocompatibility is justified and greatly needed.