## 3 Results
### RCTs (Glycine(Erythritol))  
Population: a total of 343 patients were included in the trials analyzed; an average of males and females cannot be taken into account because a few trials did not report the sex of the patients.  
Comparison: the test group had to have received nonsurgical periodontal therapy with an ultrasonic scaler or hand instruments and glycine/erythritol, while the control group had to have received SRP only (or similar therapies); erythroid was used in 67% of the studies and glycine in 33% of the studies.  
Indices: the indices evaluated were the probing pocket depth (PPD; 100%), loss of clinical attachment (CAL; 100%), bleeding on probing (BoP; 100%), plaque index (PI; 33%), approximal plaque index (GI; 33%) and gingival recessions (GR/REC; 33%).  
Outcomes: all treatments are effective in improving clinical parameters; in 83% of the studies, significant differences in clinical parameters were found for SRP treatment followed by glycine/erythritol, Table 4.  
\begin{table}
\begin{tabular}{c c c c c} \hline \hline \multirow{2}{*}{**Articles**} & **Type of** & \multirow{2}{*}{**Problem**} & **Intervention/Comparison** & **Clinical** & \\  & **Study** & & & **Indices/Follow-Up** & **Outcome** \\ \hline \hline \multirow{8}{*}{**[PERSON] et al.,**} & \multirow{8}{*}{RCT} & Test: SRP + chlorhexidine & \multirow{8}{*}{PPD, GI;} & When compared to the other two subgingival & \\  & & Test: SRP + ozonated & & irrigants, ozonated & water and 0.2\% \\  & & 10 patients with & & & \\  & & chronic periodontitis & & water & microbiological & chlorhexidine \\  & & & Test: SRP + saline solution & samples; 1 month & & \\  & & & Control: SRP & samples; 1 month & & \\  & & & Control: SRP & & efficacious, while saline & \\  & & & & & proved & \\  & & & & & to be useless. \\ \hline \hline \multirow{8}{*}{**[PERSON] et al.,**} & \multirow{8}{*}{RCT} & \multirow{8}{*}{20 patients with chronic periodontitis} & Test: SRP + chlorhexidine & \multirow{8}{*}{CAL, PPD, PI;} & Utilizing ozonized \\  & & & & & water for subgingival \\  & & & & irrigation is more & \\  & & & & advantageous than & \\  & & & & current traditional & \\  & & & & treatment approaches. & \\  & & & & & By limiting the \\
**2019**[56] & \multirow{2}{*}{RCT} & 20 patients with & Test: SRP + & \multirow{2}{*}{3 months} & \multirow{2}{*}{DROTS} & \multirow{2}{*}{DROTS} \\  & & chronic periodontitis & & & & \\  & & & ozonated water & & plaque and lowering \\  & & & & the quantity of & \\  & & & & & subgingival bacteria, \\  & & & & ozonated water helps & \\  & & & & treat & periodontal diseases. \\ \hline \hline \multirow{8}{*}{**[PERSON] et al.,** 2013**[57] & \multirow{8}{*}{RCT}} & 22 patients that & \multirow{8}{*}{Test: SRP + ozonated } & Subgingival irrigation & \multirow{8}{*}{DROTS} \\  & & exhibited mild to & & water & & with ozonated water \\ \cline{1-1}  & & moderate & & water & 8 weeks & may be a valuable \\ \cline{1-1}  & & chronic periodontitis & & Control: SRP & & adjunct to \\ \cline{1-1} \cline{2-5}  & & & & & periodontal treatment. \\ \hline \hline \end{tabular}
\end{table}
Table 3: _Cont._  
\begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Articles** & \
\begin{tabular}{c} **Type of** \\ **Study** \\ \end{tabular} & **Problem** & **Intervention/Comparison** &
\begin{tabular}{c} **Clinical** \\ **Indices/Follow-Up** \\ \end{tabular} & **Outcome** \\ \hline \hline
**Divnic-** & \begin{tabular}{c} 21 patients with \\ **[PERSON] et al.**, \\ **2022** [58] \\ \end{tabular} & \
\begin{tabular}{c} **Problem** \\ **Study** \\ \end{tabular} & **Problem** & **Intervention/Comparison** &
\begin{tabular}{c} **Clinical** \\ **Indices/Follow-Up** \\ \end{tabular} & **Outcome** \\ \hline
\begin{tabular}{c}  
The results indicate that glycine/erythritol as an adjuvant to scaling and root planing provides better clinical results in terms of improvement in periodontal indices (secondary outcome).