## 2 Current Concepts in Diagnostics & Treatment  
Considering the changing concepts of oral disease and the advancements in their treatment approaches, this Special Issue was introduced. We had an overwhelming response, with the receipt of a total of 25 submission from eminent researchers across the globe, out of which 12 articles were published. A wide range of papers were published, including three systematic reviews and meta-analysis (SRMA), three randomized controlled trials, one prospective clinical study, two retrospective clinical studies, one retrospective audit study, and two questionnaire-based studies, where one study explored the psychological burnout of dental interns, and the other assessed the knowledge and awareness of the general population regarding oral cancer. One of the systematic reviews published in the Special Issue was by [PERSON] et al., in which the review detailed randomized studies comparing the efficiency of conventional over physics forceps for dental extraction [1]. After a rigorous literature search, a total of five studies were considered for the systematic review. However, the heterogeneity in the studies limited the meta-analysis for the topic. Various parameters influencing the outcome of extraction were assessed, along with the risk of bias. The intensive review concluded that there is a lack of high-quality evidence to support the superiority of physics forceps over its conventional counterpart. Another intensive systemic review and meta-analysis was published by [PERSON] et al. where two therapeutic approaches for the treatment of Class III malocclusion, namely orthognathic and camouflage treatment, were studied [2]. A total of six articles were included for the systematic review; out of which, only three qualified to be included in the meta-analysis. Primarily due to publication bias and heterogeneity, no clear conclusion was drawn in favor of either modality, and further research was advised. The third SRMA was authored by [PERSON] et al. who studied the effect of various surgical movements conducted in order to correct skeletal malocclusion on the dimensions of the upper airway [3]. Based on the strict inclusion and exclusion criteria, a total of twenty-nine studies were included in the SRMA. The authors concluded that there was a statistically significant increase in the volume of the upper airway observed after an intervention, namely rapid maxillary expansion and a surgical advancement procedure, conducted for the correction of Class II. Another category of studies published were randomized control trials (RCTs). [PERSON] et al. presented the results of a non-blind RCT assessing the efficacy of two methods, namely auditory distraction and brief relaxation, in the reduction in anxiety levels in patients undergoing dental extraction [4]. A total of 76 subjects were recruited with 32 patients each receiving either of the interventions; the remaining 10 patients made up the control group. Individually, both intervention methods were effective in reducing anxiety; however, only brief relaxation methods managed to significantly reduce anxiety in comparison to the control group. Another interesting RCT by [PERSON] et al. compared the efficacy of nano bio-fusion gel, a nanotechnology-based product in reducing the perception of pain among fixed orthodontic patients suffering from treatment-induced gingivitis [5]. A total of 32 patients were randomly allocated to the case and control group, and the measurement of the perception of pain was performed over 3 time intervals, including the baseline, 7 th day, and 28 th day. The study concluded that there was a significant reduction in the perception of pain after the application of gel in contrast to the placebo. A prospective clinical study by [PERSON] et al. was published, where twenty-six subjects in their adolescence with class III malocclusion were recruited [6].