The kinetic behaviour of phenolic compounds, \(\alpha\)-tocopherol and pigments during the storage of different virgin olive oil samples at different temperatures (25-60 \({}^{\circ}\)C) was evaluated. Hydroxytyrosol, tyrosol and \(\alpha\)-tocopherol conformers to pseudo-zero-order kinetics, while secoriidoid derivatives of hydroxytyrosol and tyrosol, \(\alpha\)-diphenyl and total phenols apparently followed pseudo-first-order kinetics. Principal component analysis was used to transform the considered composition and degradation variables into a smaller number of uncorrelated principal components. In addition, multivariate linear regression was used to obtain several modelling equations for shelf-life prediction, considering the initial composition and easily determinable experimental variables in accelerated storage. [PERSON] et al. [5] chemically characterized and selected autochthonous Tuscany EVOOs to obtain hydroalcoholic phytocomplexes, which were assayed to establish their anti-inflammatory and vasorelaxant properties. Apigenin and luteolin were found as representative flavones; other components were pinoresinol, ligstroside and oleupreein. The extracts showed anti-inflammatory and antioxidant properties via the modulation of NF-kB and Nrf2 pathways, respectively, and good vasorelaxant activity, both in the presence and absence of an intact endothelium. [PERSON] et al. [6] studied the modulation of DPP-IV activity of two extra virgin olive oil (EVOO) phenolic extracts (BUO and OMN) using in vitro, cellular and in silico molecular modeling investigations. The in vitro DPP-IV activity assay showed a dose-dependent inhibition. Moreover, both BUO and OMN reduced the DPP-IV activity expressed by Caco-2 cells. The most abundant and representative secoriidoids, such as Oleuropein, oleacein, oleocanthal, hydroxytyrosol and tyrosol, reduced the DPP-IV activity. Finally, in silico molecular docking simulations permitted the study of the binding mode of these compounds. Oleocanthal (OLE), a characteristic and exclusive secoriidoid of the _Oleoaceae_ family, is mainly found in extra virgin olive oil (EVOO). Since the pathogenesis of rheumatoid arthritis (RA) involves inflammatory and oxidative components, this study by [PERSON] et al. [7] was designed to evaluate the preventive role of dietary OLE-supplemented effects in a collagen-induced arthritis (CIA) murine model. Dietary OLE prevented bone, joint and cartilage rheumatic affections induced by collagen. Levels of circulatory matrix metalloproteinase (MMP)-3 and proinflammatory cytokines (IL-6, IL-1\(\beta\), TNF-\(\alpha\), IL-17, IFN-\(\gamma\)) were significantly decreased in secoriidoid-fed animals. Additionally, dietary OLE was able to diminish COX-2, mPGES-1 and iNOS protein expressions, as well as PGE\({}_{2}\) levels. The mechanisms underlying these protective effects could be related to Nrf-2/HO-1 axis activation and the inhibition of relevant signaling pathways, including JAK-STAT, MAPKs and NF-\(\kappa\)B, thus controlling the production of inflammatory and oxidative mediators. Overall, these results exhibit preliminary evidence concerning OLE as a novel dietary tool for the prevention of autoimmune and inflammatory disorders, such as RA. [PERSON] et al. [8] studied the beneficial effects of oleacein (OLE), an olive secoriidoid, in an experimental model of experimental autoimmune encephalomyelitis (EAE). Treatment with OLE significantly reduced the clinical and histological signs typical of EAE by modulating the expression of pro- and anti-inflammatory cytokines and minimising the serum levels of anti-MOG35 antibodies. In addition, OLE significantly decreased the presence of oxidative system parameters, while increasing the ROS disruptor, Sestrin-3. Mechanistically, OLE prevented NLRP3 expression, the phosphorylation of p65-NF-\(\kappa\)B and decreased the synthesis of proinflammatory mediators in BV2 cells without affecting the viability and phagocytic capacity of the BV2 microglia. In addition, OLE prevented oxidative stress factor-induced apoptosis of RGC-5.