## 3 Results  
### Mass Distribution of the Agent and Blood  
The simulation of models A and B took approximately 48 min and 51 min to complete, respectively. Tables 1 and 2 show the distribution rates of the anticancer agent and blood at the outlets in models A and B, respectively. Figures 6 and 7 show the distribution rates at the LA and FA for models A and B, respectively. The blood distribution rate was calculated by dividing the mass of blood at the outlets by one at the inlet of the CCA in each model. In all analyses, including analyses for models A0 and B0 with two injection conditions, the distribution rates of the agent were not consistent with those of blood. \begin{table}
\begin{tabular}{c c c c c c c c c c c c c c c} \hline \hline  & \multicolumn{2}{c}{\
\begin{tabular}{c} **Model A0** \\ **(Driver)** \\ \end{tabular} } & \multicolumn{2}{c}{
\begin{tabular}{c} **Model A0** \\ **(Manual)** \\ \end{tabular} } & \multicolumn{2}{c}{**Model A1**} & \multicolumn{2}{c}{**Model A2**} & \multicolumn{2}{c}{**Model A3**} & \multicolumn{2}{c}{**Model A4**} & \multicolumn{2}{c}{**Model A5**} \\ \hline  & **Agent** & **Blood** & **Agent** & **Blood** & **Agent** & **Blood** & **Agent** & **Blood** & **Agent** & **Blood** & **Agent** & **Blood** \\ \hline
**LA** & 0 & 4.3 & 22.9 & 3.3 & 67.6 & 4.4 & 68.7 & 4.3 & 38.7 & 4.4 & 46.6 & 4.6 & 18.0 & 4.4 \\ \hline
**FA** & 0.1 & 5.0 & 32.9 & 3.6 & 32.4 & 5.1 & 31.3 & 5.0 & 61.3 & 5.0 & 53.4 & 5.0 & 82.0 & 5.0 \\ \hline
**STha** & 0 & 2.7 & 18 & 1.8 & 0 & 2.7 & 0 & 2.7 & 0 & 2.7 & 0 & 2.7 & 0 & 2.7 \\ \hline
**OA** & 1.8 & 4.7 & 2.1 & 4.8 & 0 & 4.7 & 0 & 4.7 & 0 & 4.7 & 0 & 4.7 & 0 & 4.7 \\ \hline
**MA** & 98.1 & 13.8 & 22.9 & 13.2 & 0 & 13.9 & 0 & 13.8 & 0 & 13.8 & 0 & 13.8 & 0 & 13.9 \\ \hline
**ICA** & 0 & 69.5 & 0.9 & 73.3 & 0 & 69.3 & 0 & 69.5 & 0 & 69.4 & 0 & 69.3 & 0 & 69.4 \\ \hline \hline \end{tabular}
\end{table} 
Table 1: Distribution rate (%) of anticancer agent and blood in models A0–A5. \begin{table}
\begin{tabular}{c c c c c c c c c c c} \hline \hline  & \multicolumn{2}{c}{\ \begin{tabular}{c} **Model B0** \\ **(Driver)** \\ \end{tabular}  } & \multicolumn{2}{c}{ \begin{tabular}{c} **Model B0** \\ **(Manual)** \\ \end{tabular}  } & \multicolumn{2}{c}{**Model B1**} & \multicolumn{2}{c}{**Model B2**} & \multicolumn{2}{c}{**Model B3**} \\ \hline  & **Agent** & **Blood** & **Agent** & **Blood** & **Agent** & **Blood** & **Agent** & **Blood** & **Agent** & **Blood** \\ \hline
**LA** & 21.6 & 6.6 & 11.2 & 6.2 & 0 & 6.7 & 0 & 6.7 & 0 & 6.6 \\ \hline
**FA** & 78.4 & 25.0 & 67.2 & 22.7 & 100.0 & 25.0 & 100.0 & 24.9 & 100.0 & 24.9 \\ \hline
**STha** & 0 & 2.8 & 0 & 3.0 & 0 & 2.8 & 0 & 2.83 & 0 & 2.8 \\ \hline
**OA** & 0 & 8.9 & 0.5 & 9.4 & 0 & 8.9 & 0 & 8.92 & 0 & 8.9 \\ \hline
**APA** & 0 & 3.5 & 0.2 & 3.4 & 0 & 3.5 & 0 & 3.49 & 0 & 3.5 \\ \hline
**PEA** & 0 & 4.0 & 8.3 & 3.8 & 0 & 4.0 & 0 & 3.97 & 0 & 4.0 \\ \hline
**MA** & 0 & 4.2 & 12.6 & 3.7 & 0 & 4.2 & 0 & 4.23 & 0 & 4.2 \\ \hline
**ICA** & 0 & 45.0 & 0 & 47.7 & 0 & 44.9 & 0 & 45.0 & 0 & 45.0 \\ \hline
**100\%** & \multicolumn{2}{c}{ \begin{tabular}{c} **LA** \\ **80\%** \\ \end{tabular}  } & \multicolumn{2}{c}{\ \begin{tabular}{c} **FA** \\ \end{tabular}  } & \multicolumn{2}{c}{ \begin{tabular}{c} **82.0\%** \\ \end{tabular}  } \\
60\% & \multicolumn{2}{c}{ \begin{tabular}{c} 67.6\% \\ \end{tabular}  } & \multicolumn{2}{c}{\ \begin{tabular}{c} 68.7\% \\ \end{tabular}  } & \multicolumn{2}{c}{ \begin{tabular}{c} 61.3\% \\ \end{tabular}  } \\
40\% & \multicolumn{2}{c}{ \begin{tabular}{c} 32.9\% \\ \end{tabular}  } & \multicolumn{2}{c}{\ \begin{tabular}{c} 32.4\% \\ \end{tabular}  } & \multicolumn{2}{c}{ \begin{tabular}{c} 31.3\% \\ \end{tabular}  } \\
20\% & \multicolumn{2}{c}{ \begin{tabular}{c} 5.0\% \\ \end{tabular}  } & \multicolumn{2}{c}{ \begin{tabular}{c} 3.6\% \\ \end{tabular}  } & \multicolumn{2}{c}{ \begin{tabular}{c} 5.1\% \\ \end{tabular}  } & \multicolumn{2}{c}{\ \begin{tabular}{c} 5.0\% \\ \end{tabular}  } & \multicolumn{2}{c}{ \begin{tabular}{c} 5.0\% \\ \end{tabular}  } \\
0\% & \multicolumn{2}{c}{