###### Abstract  
A new biotechnology based on micro-needing (MND) with low-level light/laser therapy (LLLT) that is used for hair re-growth (HR-G) needs to be standardized. The study aims to report the clinical outcomes resulting from a multicentric, retrospective, observational, case-series study in which MND with LLLT was used on patients affected by androgenic alopecia (AGA). Twenty-six patients were initially enrolled of which 15 males were classified as stages I-III of vertex by the Norwood-Hamilton scale, and 11 females was classified in stages I-II by the [PERSON] scale. Twenty patients (10 females and 10 males) were analyzed after their screening (the exclusion and inclusion criteria evaluation). The HR-G assessment was evaluated with photography, as well as the physician's and patient's global assessment scales, in addition to standardized phototrichograms, during a short follow-up at T0-baseline, TI-16 weeks. Encouraging results represented by a hair density increase of 12 \(\pm\) 2 hairs/cm\({}^{2}\) at TI after 16 weeks (16 weeks vs. 0 weeks) in the targeted area, compared with the baseline results (59 \(\pm\) 2 hairs/cm\({}^{2}\) at T1 versus 47 \(\pm\) 2 hairs/cm\({}^{2}\) at baseline), were observed using computerized trichograms with a statistically significant difference in hair re-growth (\(p\) = 0.0238). The effectiveness of MND with LLLT use has been demonstrated in mild to moderate AGA patients.  
h +
Footnote †: journal:  
hair growth [6]. In 2007, the first cleared LLLT device was introduced for MPHL by the US Food and Drug Administration (FDA) [7]. Up until the present, LLLT technology, based on the laser diode (LD) and light emitting diode (LED), has been adopted by different manufacturers to create LLLT devices; nevertheless, only some of the LLLT products are cleared by the FDA, with few articles published to support the efficacies.  
Red light and laser therapies at 660 nm have been confirmed as an effective treatment for HL, and, therefore, the use of LLLT, such as phototherapy with LED, [8] has been intensified to market HG in AGA [9; 10]. For several years, LED phototherapy has been offered as a good and safe device for the treatment of the skin, mucous, and scalp affected by inflammatory components, being employed efficaciously within the treatment of acne [11], vaginal atrophy [12], facial aging [13; 14], and, additionally, in disorders associated with HL [15]. The innovative use of combining LLLT, LED, and magnetic flux technology for the treatment of AGA seems to be the latest advancement. The synergy of emissions, including the spectrum, infrared, a soft laser, and magnetic flux helps to increase the density of the hair by activating the cellular metabolism of the hair follicles (HFs) and improving the standard and density of the prevailing hair.  
Additionally, the combined use of the micro-needling (MND) technique with LLLT has further improved HR-G in patients with AGA [16].  
This study aims to describe the impact of LLLT with MND on HR-G. The characteristics and, therefore, the outcomes of the device analyzed are reported, aspiring to clarify any doubts regarding the chance to standardize the utilization of this method.