## 3 Materials and Methods
### Materials
\({}^{1}\)H NMR (CDCl\({}_{3}\), 500 MHz) \(\delta\) 7.85-7.83 (_dd_, \(J\) = 5.45, 3.05 Hz, 2H), 7.71-7.70 (_dd_, \(J\) = 5.45, 3.00 Hz, 2H), 3.69-3.62 (_m_, 20H), 3.57-3.54 (_m_, 4H), 3.44-3.42(\(t\), \(J\) = 6.78 Hz, 2H), 3.38 (\(s\), 3H), 1.70-1.64 (\(m\), 4H), 1.59-1.54 (\(m\), 2H), 1.34-1.30 (\(m\), 6H). HRMS (ESI) Calcd. for C\({}_{28}\)H\({}_{45}\)NNaO\({}_{9}\) [M + Na]\({}^{+}\): \(m\)/z 562.2992, Found: 562.3199. 2-(2,5,8,11,14,17,20-heptaoxaoctacosan-28-yl)isoindoline-1,3-dione (Eg\({}_{6}\)C\({}_{8}\)NPht)  
**Eg\({}_{6}\)C\({}_{8}\)NPht** was prepared in a manner similar to that described for **Eg\({}_{6}\)C\({}_{6}\)NPht**, using **Eg\({}_{6}\)C\({}_{8}\)Br** instead of **Eg\({}_{6}\)C\({}_{6}\)Br**. The reaction yield was 94.7%. \({}^{1}\)H NMR (CDCl\({}_{3}\), 500 MHz) \(\delta\) 7.85-7.83 (\(dd\), \(J\) = 5.45, 3.05 Hz, 2H), 7.71-7.70 (\(dd\), \(J\) = 5.4, 3.00 Hz, 2H), 3.68-3.62 (\(m\), 2H), 3.58-3.54 (\(m\), 4H), 3.44-3.42 (\(t\), \(J\) = 6.85 Hz, 2H), 3.38 (\(s\), 3H), 1.68-1.64 (\(m\), 2H), 1.58-1.53 (\(m\), 2H), 1.33-1.30 (\(m\), 10H). HRMS (ESI) Calcd. for C\({}_{29}\)H\({}_{47}\)NNaO\({}_{9}\) [M + Na]\({}^{+}\): \(m\)/z 576.3149, Found: 576.3349. 2,5,8,11,14,17,20-heptaoxahexacosan-26-amine (Eg\({}_{6}\)C\({}_{6}\)NH\({}_{2}\))  
To a solution of **Eg\({}_{6}\)C\({}_{6}\)NPht** (4.69 g, 8.92 mmol) in 40 mL EtOH, hydrazine monohydrate (1.73 mL, 35.7 mmol) was added dropwise, and the mixture was refluxed for 2 h. The resulting solution was cooled to room temperature and evaporated to afford a white solid. The residue was dissolved with Et\({}_{2}\)O and filtered over Celite. After evaporation of the filtrate, the residue was chromatographed on silica gel with CH\({}_{2}\)Cl\({}_{2}\)/MeOH/trimethylamine (1:0.02:0.05) as the eluent to afford **Eg\({}_{6}\)C\({}_{6}\)NH\({}_{2}\)** as a pale yellow transparent oil in 97.8% yield (3.57 g, 9.03 mmol). IR (neat on NaCl) 3429, 2933, 2862, 1646, 1567, 1461, 1352, 1246, 1105, 938, 847 cm\({}^{-1}\). \({}^{1}\)H NMR (CDCl\({}_{3}\), 270 MHz) \(\delta\) 3.66-3.62 (\(m\), 20H), 3.59-3.53 (\(m\), 4H), 3.45 (\(t\), \(J\) = 8.1 Hz, 2H), 3.38 (\(s\), 3H), 2.71 (\(t\), \(J\) = 6.75 Hz, 2H), 1.74 (\(m\), 2H), 1.59-1.56 (\(t\), \(J\) = 4.05 Hz, 2H), 1.45-1.25 (\(m\), 6H). HRMS (ESI) Calcd. for C\({}_{19}\)H\({}_{42}\)NO\({}_{7}\) [M + H]\({}^{+}\): \(m\)/z 396.2961, Found: 396.3093. 2,5,8,11,14,17,20-heptaoxaheptacosan-27-amine (Eg\({}_{6}\)C\({}_{7}\)NH\({}_{2}\))  
**Eg\({}_{6}\)C\({}_{7}\)NH\({}_{2}\)** was prepared in a manner similar to that described for **Eg\({}_{6}\)C\({}_{6}\)NH\({}_{2}\)**, using **Eg\({}_{6}\)C\({}_{7}\)NPht** instead of **Eg\({}_{6}\)C\({}_{6}\)NPht**. The reaction yield was 86.2%. \({}^{1}\)H NMR (DMSO-\(d_{6}\), 270 MHz) \(\delta\) 3.53-3.50 (\(m\), 24H), 3.49-3.30 (\(m\), 2H), 3.37 (\(s\), 3H), 2.71-2.69 (\(t\), \(J\) = 5.0 Hz, 2H), 1.74 (\(m\), 4H), 1.50-1.45 (\(t\), \(J\) = 12.5 Hz, 2H), 1.40-1.30 (\(m\), 4H), 1.19-1.13 (\(m\), 2H). HRMS (ESI) Calcd. for C\({}_{20}\)H\({}_{44}\)NO\({}_{7}\) [M + H]\({}^{+}\): \(m\)/z 410.3118, Found: 410.2994. 2,5,8,11,14,17,20-heptaoxaoctacosan-28-amine (Eg\({}_{6}\)C\({}_{8}\)NH\({}_{2}\))  
**Eg\({}_{6}\)C\({}_{8}\)NH\({}_{2}\)** was prepared in a manner similar to that described for **Eg\({}_{6}\)C\({}_{6}\)NH\({}_{2}\)**, using **Eg\({}_{6}\)C\({}_{8}\)NPht** instead of **Eg\({}_{6}\)C\({}_{6}\)NPht**. The reaction yield was 81.8%. \({}^{1}\)H NMR (DMSO-\(d_{6}\), 500 MHz) \(\delta\) 3.51-3.50 (\(m\), 16H), 3.47-3.45 (\(m\), 2H), 3.45-3.41 (\(m\), 2H), 3.40-3.23 (\(m\), 6H), 3.24 (\(s\), 3H), 2.60-2.56 (\(t\), \(J\) = 10 Hz, 2H), 1.49-1.46 (\(m\), 2H), 1.40-1.36 (\(m\), 2H), 1.30-1.20 (\(m\), 6H). HRMS (ESI) Calcd. for C\({}_{21}\)H\({}_{46}\)NO\({}_{7}\) [M + H]\({}^{+}\): \(m\)/z 424.3274, Found: 424.3145.