## 7 Conclusions
\begin{table}
\begin{tabular}{c c c c} \hline \hline
**Condition** & **Compound** & **Outcome** & **Reference** \\ \hline \multirow{8}{*}{**Cardiovascular diseases**} & \multicolumn{3}{c}{Attenuate isoproterenol-induced cardiotoxicity} & [166] \\  & \multicolumn{3}{c}{Attenuate lactate-induced cardiomyocyte apoptosis} & [167] \\  & \multicolumn{3}{c}{Protect against hypoxia-induced apoptosis} & [168] \\  & \multicolumn{3}{c}{Preserve cardiac function, inhibit left ventricular remodelling, alleviate} \\  & \multicolumn{3}{c}{cardiomyocyte apoptosis} \\  & \multicolumn{3}{c}{Asiatic acid} & Inhibt p38 MAPK and ERK 1/2 phosphorylation & [170] \\  & \multicolumn{3}{c}{Protect against cardiac hypertrophy and fibrosis} & [172] \\  & \multicolumn{3}{c}{Block IL-18 activated NF-xB signaling} & [173] \\  & \multicolumn{3}{c}{Suppress inflammation and oxidative stress} & [175] \\  & \multicolumn{3}{c}{Improve vascular function} & [177] \\  & \multicolumn{3}{c}{Attenuate glycolytic injury and coagulatory disorders} & [178] \\  & \multicolumn{3}{c}{Protect human aortic endothelial cells} & [182,183] \\ \cline{2-3}  & \multicolumn{3}{c}{Asiaticoside} & \multicolumn{3}{c}{Impede endothelial hyperpermeability} & [183] \\  & \multicolumn{3}{c}{Disrupt development of early atherosclerotic events} & [181] \\ \hline \multirow{8}{*}{**Lung diseases**} & \multicolumn{3}{c}{Madecassoside} & Activate PPAR, generate HGF, impede pulmonary fibrosis & [187] \\ \cline{2-3}  & \multicolumn{3}{c}{Ameliorate lung fibrosis and inflammation} & [190] \\  & \multicolumn{3}{c}{Inhibit TLR signaling pathway} & [194] \\  & \multicolumn{3}{c}{Asiatic acid} & Activate Nrf and inhibit NLRPs inflammasome pathway & [195] \\  & \multicolumn{3}{c}{Suppress inflammatory mediators and induction of HO-1} & [196] \\ \cline{2-3}  & \multicolumn{3}{c}{Asiaticoside} & Inhibiting inflammatory cell infiltration and downregulate the NF-xB signaling pathway & [193] \\ \hline \multirow{8}{*}{**Kidney diseases**} & \multicolumn{3}{c}{Madecassoside} & Inhibit ERK phosphorylation, reduce apoptotic factors, inhibit iNOS & [201] \\ \cline{2-3}  & \multicolumn{3}{c}{Asiatic acid} & Inhibits Smad3 signaling & [203] \\  & \multicolumn{3}{c}{Inhibit NF-xB activation and inflammatory responses} & [204] \\ \hline \multirow{8}{*}{**Liver diseases**} & \multicolumn{3}{c}{Madecassoside} & Reduce inflammatory cytokines, increase antioxidant enzymes & [207] \\ \cline{2-3}  & \multicolumn{3}{c}{Resulate PI3K/AKT/mTOR and Bcl-2/Bax signaling pathways} & [212] \\  & \multicolumn{3}{c}{Suppress NF-xB/IxB\(\alpha\) and JAK1/STAT3 signaling} & [213] \\  & \multicolumn{3}{c}{Protect mitochondrial function} & [216,217,218] \\  & \multicolumn{3}{c}{Organ protective adjuvant} & [219] \\ \hline \multirow{8}{*}{**Cancer**} & \multicolumn{3}{c}{Madecassoside} & Downregulate expression of COX-2 and PGE\({}_{2}\) & [223] \\ \cline{2-3}  & \multicolumn{3}{c}{Asiaticoside} & Autophagy induction, inhibit cell migration and invasion & [226] \\ \cline{2-3}  & \multicolumn{3}{c}{Inhibit cancerous cell growth in glioblastoma} & [232,234] \\  & \multicolumn{3}{c}{Reduce inflammation, cell proliferation and induce apoptosis in colon cancer} & [236,237,239] \\ \cline{2-3}  & \multicolumn{3}{c}{Asiatic acid} & Suppress PI3K/AKT/mTOR signaling & [241] \\  & \multicolumn{3}{c}{Inhibits lung cancer cell growth} & [243] \\  & \multicolumn{3}{c}{Apoptosis of human leukemia cells} & [246] \\ \hline \multirow{8}{*}{**Diabetes**} & \multicolumn{3}{c}{Enhance glucose uptake into skeletal muscle} & [253] \\  & \multicolumn{3}{c}{Lower lipid and glucose levels} & [254] \\ \cline{1-1}  & \multicolumn{3}{c}{Reduce islet fibrosis formation} & [256] \\ \cline{1-1}  & \multicolumn{3}{c}{Protect against diabetic nephropathy} & [260] \\ \cline{1-1} \cline{2-3}  & \multicolumn{3}{c}{Improve glycemic control, lower plasma lipids, attenuate oxidative and inflammatory stress} & [257] \\ \cline{1-1}  & \multicolumn{3}{c}{Reduce insulin resistance and endothelial dysfunction} & [258] \\ \cline{1-1} \cline{2-3}  & \multicolumn{3}{c}{Asiaticoside} & Protect cochlear hair cells} & [261] \\ \hline \hline \end{tabular}
\end{table}