## 1 Introduction  
Previous studies have shown the critical role of metal-based nanoparticles in the health sciences, including their anti-bacterial, anti-fungal, and anti-viral activity, as well as their potential use in the therapy of several diseases [1]. Silver nanoparticles (AgNPs), which have unique optical and electronic properties and function in numerous ways (e.g., catalysis, degradation of environmental pollutants, biosensors, cancer therapy, and anti-bacterial activity), have received substantial attention in the fields of nanoscience and nanotechnology [2]. Applications of AgNPs in health management, including dentistry, drug delivery, and tumor imaging, as well as in every day uses, such as bio-labeling, coating for solar energy absorption, catalysis, electronics, and the food industry, have been reported [3, 4]. Additionally, silver nanoparticles are demonstrated to play a role in anti-biofilm activity and inhibit the growth of pathogenic bacteria [5]. Biofilm is a natural survival strategy that is used by various pathogens to protect them from antibiotics, biocides, and other physical or chemical challenges [6]. Biofilm is also considered an issue in the persistence of various infections [6, 7, 8]. Furthermore, studies have confirmed the potential role of nanoparticles in anti-cancer activity due to their ability to modulate biological activities [9]. Of further importance, natural compounds are suggested to possess fewer toxic manifestations and greater efficacy in the treatment of various types of cancers [10, 11]. Many synthetic approaches have been established to synthesize metal nanoparticles, such as the photochemical, sovothermal, sonochemical, and spin-coating methods [12, 13, 14, 15]. However, interest in biosynthesis, rather than physical and chemical synthesis, has grown due to the ever-increasing demand to produce clean and nontoxic chemicals, as well as biocompatible and environmentally agreeable solvents [2]. Moreover, biological synthesis is advantageous not only because of its eco-friendlier manner with respect to some of the physicochemical strategies but it has also been shown to produce a much larger quantity of NPs [16]. For this reason, biological methods that use aqueous extracts derived from plant materials have emerged as viable alternatives to the chemical and physical synthesis approaches that are still widely used as of today [17]. Thus far, plants, plant extracts, plant tissue, fruits, microorganisms, and marine algae have been used for green synthesis of metal nanoparticles [18]. During the biosynthesis of nanoparticles, plant extracts may work both as reducing agents as well as stabilizing agents [19], and this method is rapid and compatible with the large-scale synthesis of metal nanoparticles in comparison to other methods [20]. Date palm (_Phoenix dactylifera_) is one of humankind's oldest cultivated plants, and it plays a noteworthy role in the everyday life of humans; it also has important health implications. [PERSON] et al. reported the health-promoting aspects of date fruit extracts, their applications to the pharmaceutical industry, and their use for the synthesis of natural-compound-based industrial products [21]. Dates also contain various ingredients, including polyphenic compounds that exhibit anti-inflammatory, hepatotoxicity, and anti-cancer properties [22]. Moreover, they have been reported to possess anti-diabetic, hypolipidemic, and antioxidant properties [23]. This is of relevance given that the eco-friendly synthesis of AgNPs using palm date seeds has been recently proposed and was shown to be an effective strategy for improving the activity of anti-inflammatory drugs [24]. This was also touched upon by [PERSON] and [PERSON] [10], and [PERSON] et al. [3] demonstrated the anti-fungal, anti-bacterial, and catalytic activities of AgNPs synthesized by date palm.