These agricultural residues possess elevated moisture contents, rendering them susceptible to microbial proliferation and potential environmental contamination. Nevertheless, these by-products are rich in various phytochemicals, akin to those found in the edible flower heads of artichokes, including phenolic and terpenoid compounds [7; 13; 14; 15], inulin [7; 16], and dietary fiber [7; 17]. Remarkably, the phenolic content of these residues is higher than that of other phenol sources such as carrot peels, grape ponace, and spent coffee grounds [12]. Several epidemiological and pharmacological studies have demonstrated the health-promoting effects of globe artichoke extracts from non-edible plant parts, including hypolipicemic, hepatoprotective, anti-obesity, antioxidant, and anti-inflammatory activity [4; 7]. Significant antibacterial and antifungal effects are also recognized [7]. For this reason, in addition to the culinary use of the budding flowerhead, the abundant leaf biomass of this species has gained importance as a raw material to produce nutraceuticals, food preservatives, drugs and cosmetics [3; 4; 7], opening new possibilities for the valorization of artichoke crop residues. Previous studies also indicated that the quantity and quality of the bioactive compounds (mainly polyphenols) present in different non-edible plant parts depend on preharvest factors such as the genotype, growth conditions, and phenological stage [13; 18; 19; 20; 21]. The use of plant-derived substances as anti-cancer agents is an emerging aspect in the approach to cancer treatment. This trend is driven by their accessibility, affordability, and remarkable efficacy, while presenting minimal side effects compared to synthetic drugs [22]. Cancer cells display several hallmarks, including uncontrolled division, altered signaling pathways, stress responses, angiogenesis, metastasis, and immune evasion [23]. Cancer chemoprevention may be a promising strategy for blocking, inhibiting, reversing, or delaying the process of carcinogenesis, and the use of botanical supplements offers a convenient approach for the administration of potentially chemopre agents [24]. Some studies have explored the potential anti-cancer effects of artichoke and its role in cancer prevention, attributing these effects to its antioxidant and anti-inflammatory properties, but further research is needed [25]. Throughout human history, plant diseases have had an intensive and detrimental impact on both human society and the forest and agricultural environment [26; 27; 28; 29]. In recent years, there has been growing interest in sustainable and eco-friendly methods to control plant diseases, with plant extracts emerging as a promising solution. Although there are several studies about the possibility of using plant extracts in management of plant diseases, currently, little information is available on the use of artichoke leaf extracts [30; 31; 32; 33; 34]. This study highlights a landrace known as \"Carciofo Ortano\", belonging to the \"Romanesco\" varietal type as defined by [PERSON] et al. [35], which focused on the molecular, morphological, and nutritional characterization of this landrace. It is cultivated in the Lazio region, and it originated from the municipality of Orte in the province of Viterboand continues to be grown along the riverbanks of the Tiber River. A small number of dedicated farmers preserve the cultivation of \"Carciofo Ortano\" primarily for personal use, maintaining a tradition passed down through generations. However, the survival of this landrace is threatened by factors such as the aging population of custodians, limited cultivation areas mostly confined to local vegetable gardens, and the introduction of commercial varieties [35]. From the perspective of safeguarding agricultural biodiversity and advancing a circular economy paradigm, the aim of the present study was to assess the added value of the by-products of the \"Carciofo Ortano\" that are discarded during the local routine agricultural practices.