## 2 Materials and Methods
All 16 parameters, their origin and a brief description are summarized in Table 1.  
Figure 3: For each segmented GAW 5 sets of consecutive cycles are chosen for analysis. Each parameter was computed for each of the five cycle sets for each of the 20 GAW\({}_{\text{T}}\) signals. All values of one parameter calculated from one cycle set were grouped together resulting in five sets of 20 values each for every parameter. Each set of values referring to a sequence length from 5 to 100 cycles. These five sets were compared with each other for every parameter. Therefore, pairwise tests for connected samples using SPSS Statistics version 21 were performed. For each test the H\({}_{0}\) Hypothesis was rejected if the p-value was equal or less than 0.05. For the general linear model (GLM), repeated measures with five within-subject variables (i.e., the five sequence lengths) were chosen. The default setting of a saturated model with a Type III sum of squares was retained. We applied Bonferroni correction to pairwise comparisons (see Figure 4) by multiplying p-values of post hoc tests by five. The \(p\)-values were clipped at 1. The workflow of the entire statistical analysis is shown in Figure 4. \begin{table}
\begin{tabular}{||p{113.8 pt} p{113.8 pt} p{113.8 pt}||} \hline \hline
**Parameter (Unit) and Reference** & **Abbreviation** & **Parameter Description** \\ \hline \multicolumn{3}{||c||}{**Period Perturbation Measures (PPM)**} \\ \hline _Mean Jitter_ (ms) [44] & _MJit_ & Mean deviation in duration between cycle pairs \\ _Jitter_ (\%) (a.u.) [44] & _Jit_(\%) & Normalized mean deviation in duration between cycle pairs \\ _Jitter Factor_ (a.u.) [45] & _JitFac_ & Normalized mean deviation of reciprocal in duration between cycle pairs \\ _Jitter Ratio_ (a.u.) [46] & _JitRat_ & Normalized mean deviation in duration between cycle pairs \\ _Period Perturbation Quotient_-3\% (a.u.) [47]1  & _PPQ3_ & Difference in cycle lengths based on the mean difference between each inner cycle and its neighboring cycles \\ _Period Perturbation Factor_ (a.u.) [47]1  & _PPE_ & Mean normalized deviation in duration between cycle pairs \\ _Relative Average Perturbation Beliamowicz_ (a.u.) [48] & \(RAP_{B}\) & Difference in cycle lengths based on the difference between each inner cycle and its neighboring cycles \\ _Relative Average Perturbation Koke_ (a.u.) [49] & \(RAP_{K}\) & Normalized difference in cycle lengths based on the difference between each inner cycle and its neighboring cycles \\ _Relative Average Perturbation Koke_ (a.u.) [49] & \(RAP_{K}\) & Normalized mean quadratic deviation in duration between each cycle and an average cycle \\ _Period Variability Index_ (a.u.) [50] & _PVI_ & Normalized mean quadratic deviation in duration between each cycle and an average cycle \\ \hline \multicolumn{3}{||c||}{**Amplitude Perturbation Measures (APM)**} \\ \hline _Mean Shimmer_ (decibel) [44] & _MShim_ & Mean logarithmized deviation in dynamic range 2  & _MShim_ & Mean logarithmized deviation in dynamic range between cycle pairs \\ _Shimmer_ (\%) (dB/log10(pixel)) [51] & _Shim_(\%) & Normalized mean logarithmized deviation in dynamic range between cycle pairs \\ _Amplitude Perturbation Quotient_-3\% (a.u.) [47] & _APQ3_ & Difference in dynamic range based on the mean difference between each inner cycle and its neighboring cycles \\ _Amplitude Perturbation Factor_ (a.u.) [47] & _APF_ & Mean normalized deviation in dynamic range between cycle pairs \\ _Amplitude Variability Index_ (decibel) [50] & _AVI_ & Logarithmized normalized mean quadratic deviation in dynamic range between each cycle and an average cycle \\ \hline \multicolumn{3}{||c||}{**Energy Perturbation Measures (EPM)**} \\ \hline _Energy Perturbation Quotient_-3\% (a.u.) [47] & _EPQ3_ & Difference in energy based on the mean difference between each inner cycle and its neighboring cycles \\ _Energy Perturbation Factor_ (a.u.) [47] & _EPF_ & Mean normalized deviation in energy between cycle pairs \\ \hline \hline \end{tabular}
\end{table}