## 1 Introduction  
The dialyzable leukocyte extract is a biocompound described for the first time in 1949 by [PERSON] [1]. The extract is obtained from fresh human or animal blood or lymphoid tissues [2]. In order to preserve the properties of the dialyzable leukocyte extract, it is necessary to keep it vacuum-sealed and refrigerated until use.  
Our research team worked with the dialyzable leukocyte extract from bovine spleen (bDLE). The spleen was chosen because it is one of the largest lymphoid organs, rich in nutrients, and it was obtained from an animal already certified as safe for human consumption. Furthermore, the consumption of high amounts of bovine meat guarantees the availability of our raw material, even in the case that the production volume needs to be increased. Finally, the bovine spleen is commonly discarded by slaughterhouses, and repurposing it decreases waste.  
To produce the extract, bovine spleens are mechanically disaggregated, dialyzed against a 10-12 kDa cut-off dialysis membrane, and tested for the presence of lipopolysaccharide-charitable (LPS) to ensure a pyrogen free product. The resulting product is a bDLE commercialized under the name IMMUNEPOTENT CRP(r), and it is used as complement for the treatment of various pathological conditions including cancer, inflammation, immunity disorders, and viral infections [2, 3].  
IMMUNEPOTENT CRP(r) contains bioactive peptides smaller than 12 kDa that possesses antioxidant, anti-inflammatory, and antitumoral properties [4]. Several techniques are employed to preserve the bioactive properties of the natural compounds during the production process [5].  
Dehydration is one of the oldest preservation techniques. The main objective of dehydration is to extend the shelf-life of the product without the need to refrigate it; additionally, dehydration reduces volume and mass and, therefore, the cost of transport and storage. Dehydrated goods can be reconstituted to their original form by adding water, making this technique exceptionally convenient [6]. Dehydration also augments nutrient concentration by increasing the amounts of proteins, fats, and carbohydrates present per unit of weight [7].  
The purpose of this study is to improve the production process of the dialyzable leukocyte extract derived from bovine spleen without decreasing its antioxidant, anti-inflammatory, and antitumoral properties.  
We propose that including dry heating to the IMMUNEPOTENT CRP(r) production process will be beneficial for our product quality and safety. Furthermore, dry weight formulations are more accurate and practical for standardization of the final product. To test this hypothesis, dialyzable spleen extract was obtained from fresh or dry spleens and characterized by infrared analysis, zeta potential, scanning electron microscope, X-ray diffraction and bromatology, and its antioxidant, anti-inflammatory and antitumor biological activities were evaluated.  
Our study is original because many studies have focused on the biological properties of dialyzable leukocyte extracts [2; 4; 8; 9], but to our knowledge, there are no previous studies reporting substantial modifications to their production process.