# Potential New Treatments for Knee OA: A Prospective Review of Registered Trials  
[PERSON]  
1 Department of Orthopedics, \"[PERSON]\" University of Medicine and Pharmacy of Timisoara,  
Eftimie Murgu Square No 2, 300041 Timisoara, Romania; [EMAIL_ADDRESS] (M.L. ); [EMAIL_ADDRESS] (D.V. ); [EMAIL_ADDRESS] (M.A.-Q. ); [EMAIL_ADDRESS] (R.P.) [PERSON]  
1 Department of Physics, \"[PERSON]\" University of Medicine and Pharmacy of Timisoara,  
Eftimie Murgu Square No 2, 300041 Timisoara, Romania; [EMAIL_ADDRESS] (M.L. ); [EMAIL_ADDRESS] (D.V. ); [EMAIL_ADDRESS] (M.A.-Q. ); [EMAIL_ADDRESS] (R.P.) [PERSON]  
1 Department of Physics, \"[PERSON]\" University of Medicine and Pharmacy of Timisoara,  
Eftimie Murgu Square No 2, 300041 Timisoara, Romania; [EMAIL_ADDRESS] (M.L. ); [EMAIL_ADDRESS] (D.V. ); [EMAIL_ADDRESS] (M.A.-Q. ); [EMAIL_ADDRESS] (R.P.) [PERSON]  
2 Department of Plastic Surgery, \"[PERSON]\" University of Medicine and Pharmacy of Timisoara,  
Eftimie Murgu Square No 2, 300041 Timisoara, Romania; [EMAIL_ADDRESS] (C.D. ); [EMAIL_ADDRESS] (V.B.) [PERSON]  
1 Department of Orthopedics, \"[PERSON]\" University of Medicine and Pharmacy of Timisoara,  
Eftimie Murgu Square No 2, 300041 Timisoara, Romania; [EMAIL_ADDRESS] (M.L. ); [EMAIL_ADDRESS] (D.V. ); [EMAIL_ADDRESS] (M.A.-Q. ); [EMAIL_ADDRESS] (R.P.) [PERSON]  
2 Department of Plastic Surgery, \"[PERSON]\" University of Medicine and Pharmacy of Timisoara,  
Eftimie Murgu Square No 2, 300041 Timisoara, Romania; [EMAIL_ADDRESS] (C.D.) [PERSON]  
1 Department of Physics, \"[PERSON]\" University of Medicine and Pharmacy of Timisoara,  
Eftimie Murgu Square No 2, 300041 Timisoara, Romania; [EMAIL_ADDRESS] (M.L. ); [EMAIL_ADDRESS] (D.V. ); [EMAIL_ADDRESS] (M.A.-Q. ); [EMAIL_ADDRESS] (R.P.) [PERSON]  
3 Faculty of Medicine, \"[PERSON]\" University of Medicine and Pharmacy of Timisoara,  
Eftimie Murgu Square No 2, 300041 Timisoara, Romania; [EMAIL_ADDRESS]  
[PERSON]  
1 Department of Orthopedics, \"[PERSON]\" University of Medicine and Pharmacy of Timisoara,  
Eftimie Murgu Square No 2, 300041 Timisoara, Romania; [EMAIL_ADDRESS] (M.L. ); [EMAIL_ADDRESS] (D.V. ); [EMAIL_ADDRESS] (M.A.-Q. ); [EMAIL_ADDRESS] (R.P.) [PERSON]  
2 Department of Plastic Surgery, \"[PERSON]\" University of Medicine and Pharmacy of Timisoara,  
Eftimie Murgu Square No 2, 300041 Timisoara, Romania; [EMAIL_ADDRESS] (C.  
plane (varus), incomplete extension, decreased range of motion, instability, constant pain, and serious disability [1; 4; 7; 8]. Current treatments include lifestyle changes, physical therapy, walking aids, nonsteroidal anti-inflammatory drugs (NSAIDs), and intraarticular injections (IA). Surgical procedures are aimed at restoring limb alignment (high tibial osteotomy) or entirely replacing the diseased joint (arthroplasty) [3; 7; 9; 10; 11; 12]. The surgical management for OA of the knee guideline was developed in 2015. It summarizes the current knowledge and is endorsed by several societies [9]. Obese patients and those with chronic pain have less improvement in outcomes with total knee arthroplasty (TKA). Patients with diabetes are at higher risk for complications after TKA [9]. Peri-articular local anesthetic infiltration, peripheral nerve blockade, decrease postoperative pain and opioid requirements. Neuraxial anesthesia may improve selected perioperative outcomes and decrease some complications [9]. Tourniquet decreases blood loss but increases short term postoperative pain. Tranexamic acid, as with virtually all major surgeries, significantly reduces blood loss [9]. There appears to be no difference in outcome, function, or complications between cruciate retaining and posterior stabilized implants, all-polyethylene or modular tibial components cemented or cementless fixation, especially on the femur, as well as patellar resurfacing. For OA predominantly of the medial compartment, unicompartmental arthroplasty has similar outcomes compared to high tibial osteotomy but more revisions versus total knee replacement [9].