# Tabular Data Generation to Improve Classification of Liver Disease Diagnosis
## 2 Related Works  
### Liver Disease Diagnosis  
The liver is the main laboratory of the human body. About 20 million chemical reactions per minute occur in this organ. Here, blood proteins are synthesized (for example, immunoglobulins responsible for the so-called humoral immunity of the whole organism, albumin, which hold the required volume of fluid in the bloodstream, and others), the synpaper of bile acids, which are substances necessary for the digestion of food in the small intestine, and the accumulation and breakdown of glucose as the main source of energy for the body [18]. The liver metabolizes fats and detoxifies toxins. The slightest violation of at least one of the functions of the liver leads to serious disturbances in the work of the whole organism. In mild cases, acute hepatitis is practically asymptomatic, being detected only during random or targeted examination (for example, in the workplace among persons in contact with hepatotropic poisons, or in the household with regard to poisoning with mushrooms, etc.). In more severe cases (for example, with toxic hepatitis), the clinical symptoms of the disease develop rapidly, often in combination with signs of general intoxication and toxic damage to other organs and systems. During the disease, icteric coloration of the skin and mucous membranes, whitish-clay-colored stools, saturated dark-colored (\"beer-colored\") urine, and hemorrhagic phenomena are characteristic. The color of the skin is orange or saffron. However, in mild cases of jaundice, the yellowing of the skin and eyes may only be noticeable in daylight. The first sign of jaundice is typically the yellowing of the whites of the eyes and the soft palate's mucous membrane. Other symptoms may include frequent nosebleeds and petechiae, itching, slow heartbeat, depression, irritability, insomnia, and other signs of damage to central nervous system. The liver and spleen are slightly enlarged and slightly painful in liver disease. Its size may decrease with especially severe lesions and the predominance of necrotic changes in the liver (acute dystrophy). Laboratory tests may show elevated bilirubin levels (100-300 umol/L or higher), increased activity of certain serum enzymes such as aldolase, aspartate aminotransferase, and alanine aminotransferase (levels higher than 40 units), lactate dehydrogenase, decreased albumin levels, and increased globulin levels. Additionally, there may be indicators of protein deposits in sedimentary samples (such as thymol and sublimate). The liver's production of fibrinogen, prothrombin, and VII and V coagulation factors is impaired because of hemorrhagic phenomena, considering the epidemiological situation in identifying the nature and cause of the disease. In unclear cases, first, one should think about viral hepatitis. Detection of the so-called Australian antigen is characteristic of serum hepatitis B (it is also detected in virus carriers, but rarely in other diseases x). Mechanical (subhepatic) jaundice usually occurs acutely only when a stone in cholelithiasis blocks the common bile duct. However, in this case, jaundice is preceded by an attack of biliary colic; bilirubin in the blood is mostly straight, and the stool is discolored. With hemolytic adrenal jaundice, free (indirect) bilirubin is determined in the blood, the stool is intensely colored, and the osmotic resistance of erythrocytes is usually reduced. In the case of false jaundice (due to skin staining with caroten with prolonged and abundant consumption of oranges, carrots, and pumpkin), the sclera is usually not colored, and hyperbilirubinemia is absent. Scanning the liver allows for the determination of its size; with hepatitis, sometimes there is a reduced or uneven accumulation of a radioisotope drug in the liver tissue. In some cases, increased accumulation in the spleen occurs. The research by [PERSON] et al. [19] focuses on developing a prediction system for liver disease using a specific type of machine learning algorithm called Convolutional Neural Network (CNN).