## 3 Results
### Single Locus Associations
\begin{table}
\begin{tabular}{c c c c c c c c c} \hline \hline
**Gene/SNV** & **Allele** & **Controls (N = 240)** & **IUFD** & **OR (95\% CI)** & \(\chi^{2}_{p\text{Value}}\) & **RM** & **OR (N = 220)** & **OR (95\% CI)** & \(\chi^{2}_{p\text{Value}}\) \\ \hline FOLR1 & G & 233 (0.971) & 154 (0.963) & 1.297 & \(\chi^{2}_{p\text{Value}}=0.212\) & 207 (0.941) & 2.09 & \(\chi^{2}_{p\text{Value}}=0.115\) \\ \cline{2-10} rs2071010 & A & 7 (0.029) & 6 (0.037) & (0.427-3.932) & 0.645 & 13 (0.059) & (0.818-5.339) & \(\chi^{2}_{p\text{Value}}=0.115\) \\ \hline FOLR1 & C & 107 (0.446) & 83 (0.519) & 0.746 & \(\chi^{2}_{p\text{Value}}=2.046\) & 112 (0.509) & 0.776 & \(\chi^{2}_{p\text{Value}}=1.841\) \\ rs630074 & T & 133 (0.554) & 77 (0.481) & (0.500-1.115) & 0.153 & 108 (0.491) & (0.537-1.120) & 0.174 \\ \hline FOLH1 & G & 231 (0.963) & 144 (0.900) & 2.852 & \(\chi^{2}_{p\text{Value}}=6.400\) & 208 (0.945) & 1.481 & \(\chi^{2}_{p\text{Value}}=0.765\) \\ rs1886492 & A & 9 (0.037) & 16 (0.100) & (1.228-6.624) & 0.011 & 12 (0.055) & (0.612-3.585) & 0.382 \\ \hline GGH & G & 220 (0.917) & 148 (0.925) & 0.892 & \(\chi^{2}_{p\text{Value}}=0.091\) & 207 (0.941) & 0.691 & \(\chi^{2}_{p\text{Value}}=1.013\) \\ rs11545078 & A & 20 (0.083) & 12 (0.075) & (0.423-1.879) & 0.763 & 13 (0.059) & (0.335-1.424) & 0.314 \\ \hline GGH & G & 173 (0.721) & 119 (0.744) & 0.889 & \(\chi^{2}_{p\text{Value}}=0.256\) & 161 (0.732) & 0.946 & \(\chi^{2}_{p\text{Value}}=0.070\) \\ rs378149 & A & 67 (0.279) & 41 (0.256) & (0.565-1.399) & 0.613 & 59 (0.268) & (0.628-1.427) & 0.792 \\ \hline SLC19A1 & T & 122 (0.508) & 79 (0.494) & 1.060 & \(\chi^{2}_{p\text{Value}}=0.082\) & 97 (0.441) & 1.311 & \(\chi^{2}_{p\text{Value}}=2.092\) \\ rs1051266 & C & 118 (0.492) & 81 (0.506) & (0.711-1.582) & 0.775 & 123 (0.559) & (0.908-1.893) & 0.148 \\ \hline \end{tabular}
\end{table} 
Table 4: Allele frequencies of six examined polymorphisms in RM, IUFD patients and controls. \begin{table}
\begin{tabular}{c c c c c c c c c c} \hline \hline
**Gene, SNV** & **Genotypes/Model** & **Controls (N = 120)** & **IUFD** & **OR** & **OR** & **OR** & **OR** & **OR** & **OR** \\ \hline \multirow{6}{*}{FOLR1} & GG & 113 (94.2) & 74 (92.5) & 1.00 & & & 97 (88.2) & 1.00 & & \\ \cline{2-10}  & GA & 7 (5.8) & 6 (7.5) & \begin{tabular}{c} 1.31 \\ (0.42-4.05) \\ \end{tabular}  & 0.642 & 273.0 & 13 (11.8) & \begin{tabular}{c} 2.16 \\ (0.83-5.64) \\ \end{tabular}  & 0.106 & 319.8 \\ \cline{2-10}  & AA & 0 (0.0) & 0 (0.0) & — & & 0 (0.00) & & \\ \cline{2-10}  & Dominant & — & — & — & — & — & — & — & — \\ \cline{2-10}  & Recessive & — & — & — & — & — & — & — & — \\ \cline{2-10}  & Over dominant & — & — & — & — & — & — & — & — \\ \cline{2-10}  & Log-additive & 120 (60.0) & 80 (40.0) & \begin{tabular}{c} 1.31 \\ (0.42-4.05) \\ \end{tabular}  & 0.642 & 273.0 & 110 (47.8) & \begin{tabular}{c} 2.16 \\ (0.83-5.64) \\ \end{tabular}  & — & 319.8 \\ \hline \multirow{6}{*}{FOLR1} & TT & 36 (30.0) & 23 (28.8) & 1.00 & & & 24 (21.8) & 1.00 & \\ \cline{2-10}  & TC & 61 (50.8) & 31 (38.8) & 0.80 & & 0.083 & 270.2 & 60 (54.5) & 1.48 & 0.337 & 322.2 \\ \cline{2-10}  & CC & 23 (19.2) & 26 (32.5) & \begin{tabular}{c} 1.77 \\ (0.82-3.81) \\ \end{tabular}  & & & & 26 (23.6) & \begin{tabular}{c} 1.70 \\ (0.79-3.64) \\ \end{tabular}  & & & & & & \\ \cline{2-10}  & Cominant & 84 (70.0) & 57 (71.2) & \begin{tabular}{c} 1.06 \\ (0.57–1.98) \\ \end{tabular}  & 0.849 & 273.2 & 86 (78.2) & \begin{tabular}{c} 1.54 \\ (0.84–2.79) \\ \end{tabular}  & 0.157 & 320.4 \\ \hline \multirow{2}{*}{FOLR1} & \multirow{2}{*}{ \begin{tabular}{c} Optimant \\ rs630074 \\ \end{tabular}  } & 97 (80.8) & 54 (67.5) & \begin{tabular}{c} 2.03 \\ (1.06-3.90) \\ \end{tabular}  & 0.033 & 268.7 & 84 (76.4) & \begin{tabular}{c} 1.31 \\ (0.69–2.46) \\ \end{tabular}  & 0.408 & 321.7 \\ \hline \multirow{2}{*}{Over dominant} & 59 (49.2) & 49 (61.2) & \begin{tabular}{c} 0.61 \\ (0.34–1.09) \\ \end{tabular}  & 0.092 & 270.4 & 50 945.5 & \begin{tabular}{c} 1.16 \\ (0.69–195) \\ \end{tabular}