## 2 Materials and Methods
### Chemistry
N\({}^{\prime}\)-[(2-Methylphenyl)methylidene)]-4-[(4-methylphenyl)sulfonyl]benzoylhydrazzide_**(3b)**. Yield 94.0%. mp 202.8-203.2 \({}^{\circ}\)C. HPLC tR: 8.656 min, purity: 98.85%. 1H NMR (DMSO6, 400 MHz) \(\delta\): 2.40 (s, 3H, C2\({}^{\prime\prime}\)-CH3), 2.41 (s, 3H, C1-CH3), 7.17-7.19 (d, 2H, J = 8.8 Hz, H2\({}^{\prime}\), H6\({}^{\prime}\)), 7.22-7.24 (d, 1H, J = 7.6 Hz, H3\({}^{\prime\prime}\)), 7.26-7.30 (q, 2H, J = 7.2 Hz, J = 6.4 Hz, H4\({}^{\prime\prime}\), H5\({}^{\prime\prime}\)), 7.45-7.47 (d, 2H, J = 8.0 Hz, H2, H6), 7.75-7.77 (d, 2H, J = 8.0 Hz, H3\({}^{\prime}\), H5), 7.81-7.83 (d, 1H, J = 8.4 Hz, H6\({}^{\prime\prime}\)), 7.89-7.91 (d, 2H, J = 8.8 Hz, H3\({}^{\prime}\), H5), 8.70 (s, 1H, N=CH), 11.83 (s, 1H, CONH). 13C NMR (DMSO-d6, 100 MHz) \(\delta\): 19.43 (C2\({}^{\prime\prime}\)-CH3), 21.63 (C1-CH3), 122.58 (C2\({}^{\prime}\), C6\({}^{\prime}\)), 126.29 (C5\({}^{\prime\prime}\)), 126.63 (C3\({}^{\prime\prime}\)), 128.70 (C4\({}^{\prime}\)), 130.05 (C3, C5), 130.29 (C2, C6), 130.75 (C4\({}^{\prime\prime}\)), 131.31 (C4), 131.65 (C6\({}^{\prime\prime}\)), 132.60 (C3\({}^{\prime}\)), C5\({}^{\prime}\)), 132.92 (C1\({}^{\prime\prime}\)), 137.35 (C2\({}^{\prime\prime}\)), 146.46 (C1), 147.18 (N=CH), 151.64 (C1\({}^{\prime}\)), 162.29 (C=O). MS (ESI) _m_/_z_ calcd. for C22H20N2O4S [M+H]+ 409.12, found 409.62. N\({}^{\prime}\)-[(3-Methylphenyl)methylidene)-4-[(4-methylphenyl)sulfonyl]benzoylhydrazzide_**(3c)**. Yield 98.1%. mp 162.8-163.2 \({}^{\circ}\)C. HPLC tR: 9.047 min, purity: 96.07%. 1H NMR (DMSO, 400 MHz) \(\delta\): 2.35 (s, 3H, C3\({}^{\prime\prime}\)-CH3), 2.42 (s, 3H, C1-CH3), 7.18-7.20 (d, 2H, J = 8.4 Hz, H2\({}^{\prime}\), H6\({}^{\prime}\)), 7.24-7.25 (d, 1H, J = 7.2 Hz, H4\({}^{\prime\prime}\)), 7.32-7.35 (t, 1H, J = 8.0 Hz, J = 7.2 Hz), 7.48-7.50 (d, 3H, J = Hz, H2, H6, H2\({}^{\prime\prime}\)), 7.55 (s, 1H, H6\({}^{\prime\prime}\)), 7.77-7.79 (d, 2H, J = 8.4 Hz, H3\({}^{\prime}\)), 7.90-7.92 (d, 2H, J = 8.4 Hz, H3\({}^{\prime}\), H5\({}^{\prime}\)), 8.38 (s, 1H, N=CH), 11.82 (s, 1H, CONH). 13C NMR (DMSO-d6, 100 MHz) \(\delta\): 20.84 (C3\({}^{\prime\prime}\)-CH3), 21.16 (C1-CH3), 122.10 (C2\({}^{\prime}\), C6\({}^{\prime}\)), 124.54 (C5\({}^{\prime\prime}\)), 127.36 (C6\({}^{\prime\prime}\)), 128.23 (C4\({}^{\prime}\)), 128.71 (C4\({}^{\prime\prime}\)), 129.64 (C3, C5), 130.30 (C2, C6), 130.88 (C2\({}^{\prime\prime}\)), 131.20 (C4), 132.46 (C3\({}^{\prime}\), C5\({}^{\prime}\)), 134.12 (C1\({}^{\prime\prime}\)), 138.07 (C3\({}^{\prime\prime}\)), 146.01 (C1), 148.14 (N=CH), 151.18 (C1\({}^{\prime}\)), 161.97 (C=O). MS (ESI) _m_/_z_ calcd. for C22H20N2O4S [M]+ 408.11, found 408.04. N\({}^{\prime}\)-[(4-Methylphenyl)methylidene)-4-[(4-methylphenyl)sulfonyl]benzoylhydrazzide_**(3d)**. Yield 88.5%. mp 209.2-210.0 \({}^{\circ}\)C. HPLC tR: 8.614 min, purity: 98.15%. 1H NMR (DMSO6,400 MHz) \(\delta\): 2.33 (s, 3H, C4\({}^{\prime\prime}\)-CH3), 2.42 (s, 3H, C1-CH3), 7.18-7.20 (d, 2H, J = 7.6 Hz, H2\\(N^{\prime}\)_-[(2-Methoxyphenyl)methylidene)]-4-[(4-methylphenyl)]sulfonylylbenzohydrazide_ (**3e**). Yield 97.2%. mp 199.3-199.8 \({}^{\circ}\)C. HPLC tR: 7.147 min, purity: 97.79%. 1H NMR (DMSO-d6, 400 MHz) & 2.41 (s, 3H, C1-CH3), 3.85 (s, 3H, OCH3), 6.99-7.03 (t, 1H, J1 = J2 = 7.6 Hz, H5\({}^{\prime\prime}\)), 7.09-7.11 (d, 1H, J = 8.4 Hz, H3\({}^{\prime\prime}\)), 7.17-7.19 (d, 2H, J = 8.8 Hz, H2\({}^{\prime}\), H6\({}^{\prime}\)), 7.39-7.43 (t, 1H, J1 = J2 = 7.2 Hz, H4\({}^{\prime\prime}\)), 7.47-7.49 (d, 2H, J = 8.4 Hz, H2, H6), 7.76-7.78 (d, 2H, J = 8.0 Hz, H3, H5), 7.85-7.87 (d, 1H, J = 7.6 Hz, H6\({}^{\prime\prime}\)), 7.92-7.94 (d, 2H, J = 8.8 Hz, H3\({}^{\prime}\), H5\({}^{\prime}\)), 8.78 (s, 1H, N=CH). 11.89 (s, 1H, CONH).