# The Central Dogma of Information
## 7 Comparison between Info-Autopoiesis and Genomic Flow of Information  
Figure 7 shows side by side simplified diagrams of info-autopoiesis in a human being and the genomic flow of information in a prokaryote. What is clear in both instances is that the human being and the cell are in continuous interaction with their environment. The human being responds to 'Sensory Signals' that allow info-autopoiesis to govern its actions in its environment in pursuit of satisfaction of its physiological and/or relational needs. In a similar way, the cell responds to 'Cell Signals' that direct the genomic flow of information to best respond to the environment also in pursuit of satisfaction of its physiological and/or relational needs. In the case of the human being, info-autopoiesis governs the self-production and flow of information starting from 'Sensory Signals'. The Central Nervous System is an organ that allows the processing of electrical signals (info-autopoiesis) for meaning-making (semantic information) so that the human body can engage in syntactic information generation that allows for its continued renewal. In other words, internally the human being produces semantic information which guides its expression through actions that externalize syntactic information and mold matter to satisfy its physiological and/or relational needs. Similarly, the prokaryotic cell is subjected to 'Cell Signals' of many kinds that guide its response and actions in the environment. The cell genome (DNA) may be considered as a biochemical organ for meaning-making (semantic information) internal to the cell nucleus that results in the production of proteins (syntactic information) external to the cell nucleus. In other words, DNA allows syntactic information generation in the form of proteins so that the cell acts on the environment in pursuit of satisfying its physiological and/or relational needs. This also means that there is not information in DNA per se, thus no 'genomic flow of information'. Rather, the genomic functions that exist perform the self-production of semantic information internal to the cell nucleus, from which syntactic information is externalized. This perspective allows the reconciliation of the self-production of information of both a human being and a prokaryotic cell from the perspective of [PERSON]'s 'difference which makes a difference'. To illustrate this, Figure 8 shows a parallel portrayal of the central dogma of information to that of the central dogma of molecular biology in Figure 6. Previously, the central dogma of information was stated as 'info-autopoiesis results in endogenous semantic information that irreversibly becomes exogeneous syntactic information'. Now, to word it in a parallel fashion as the central dogma of molecular biology it is phrased as 'once semantic information has got into syntactic information it can't get out again'. Comparing Figure 6a to Figure 8a we find the following parallel relationships:  
Cell Signals \(\leftrightarrow\) Sensory Signals: which permit the organism to establish a means of access to the environment with the potential to understand the environment through repetition and recursion. It is only through these signals that the respective organism can interact with the environment. DNA \(\leftrightarrow\) Info-autopoiesis: which requires interpreting DNA as a biochemical organ for meaning-making (of transcription of DNA into semantic information as mRNA) internal to the cell nucleus; and info-autopoiesis as the self-referenced, recursive, interactive process of transcription or rearrangement of electrical signals in the Central Nervous System (CNS) for meaning-making (into semantic information). RNA \(\leftrightarrow\) Semantic Information: RNA embodies the result of meaning-making by DNA; and Semantic Information is the result of the info-autopoietic process. Protein \(\leftrightarrow\) Syntactic Information: RNA translates into Proteins outside of the cell nucleus; and Semantic Information translates into Syntactic Information outside of the human organism.