# Genetic Engineering Approaches for the Microbial Production of Vanillin
## Abbreviations  
**Abbreviation** **Description**, _gene_  
**1,3 DPG** 3-phospho-D-glycerol-phosphate  
**3 DSD** 3-dehydrodiskimate dehydratase, _aroZ_, _3 DSD_, _asbF_  
**4 CL** 4-hydroxycinnamoyl-CoA ligase, _4 CL_  
**4 HBS** 4-hydroxybenzaldehyde synthetase  
**4 PG** 4-n-propylguaiacol  
**ACAR**  aldehyde carboxylic acid reductase, _car_  
**Ac-CoA**  acetyl-coenzyme A  
**Acc**  acetate  
**AcP**  acetyl phosphate  
**ADH**  alcohol dehydrogenase, _AHD6_  
**ADO**  aromatic dioxygenase, _ado_  
**AKR**  aldehyde reductases  
**ALDR**  aldehyde reductases, _areA_  
**APX1**  ascorbate oxidase  
**ARO4**  DAHP synthase, _aro4_  
**ARO7**  chorismate mutase, _aro7_, _csm_  
**AroB**  DHQ synthase, _aroB_  
**AroD**  DHQ dehydratase, _aroD_  
**AroE**  Shikimate dehydrogenase, _aroE_  
**AroF**, **AroG**, **AroH**  DAHP synthase feedback regulated isoenzymes, _aroF, aroG, aroH_  
**BFD**  Benzoylformate decarboxylase, _BFD_  
**C3H** 4-coumaric acid 3-hydroxylase, _sam5_, _IbraBC_  
**C4H**  cinnamate-4-hydroxylase, _C4H_  
**CADH**  coniferly alcohol dehydrogenase, _calA_  
**CALDH**  coniferly aldehyde dehydrogenase, _calB_  
**CCR**  cinnamoyl-CoA reductase, _crcr_  
**COMT**  caffeic acid O-methyltransferase transferase, _comt_  
**CPL**  chorismate-pyruvate lyase, _ubiC_  
**CPR**  cytochrome P450 reductase, _CPR_  
**CSO**  carotenoid oxygenase, _cso2_  
**DAHP** 3-deoxy-D-arabino-heptulosonate-7-phosphate  
**DCDDH** 1,4-dicarboxylic acid dehydrogenase  
**DHGA** 3,4-dihydroyphenylglyoxylate  
**DHMA** 3,4-dihydroromandelate  
**DHQ** 3-dehydroquinic acid  
**DHS** 3-dehydrodiskimic acid  
**DyP**  dye-decolorism peroxidase  
**E4P**  erythromes-4-phosphate  
**ECH**  enoyl-CoA hydratase, _echt_  
**EUGH**  eugenol hydroxylase, _ehyA, ehyB_  
**F6P**  fructose 6-phosphate  
**FCS**  feruloyl-CoA synthetase, _fc_  
**FDC**  ferulic acid decarboxlase, _fdc_  
**G6P**  glucose 6-phosphate  
**GAP**  D-glyceroldehyde 3-phosphate  
**GapC**  GAP dehydrogenase  
**GDH1**  NADP+ dependent glutamate dehydrogenase, _gdh1_  
**GDH2**  NAD+ dependent glutamate dehydrogenase, _gdh2_  
**GHA**  citrate synthase, _gdhA_  
**GPP1**  glycerol-1-phosphate, _gpp1_  
**HBH**  Hydroxybenzoate hydroxylase, _pohA, hbh_  
**HCHL** 4-hydroxycinnamate CoA-hydratase/lyase  
**HCT**  hydroxycinnamoyl transferase  
**HCys**  homocysteine  
**HMA**  hydroxylandelate  
**HmaS**  
hydroxymandelate synthase, _HmaS_  
hydroxymandelate oxidase, _HMO_  
**HMPHP-CoA**  
4-hydroxy-3-methoxyphenyl-\(\beta\)-hydroxypropionyl-CoA  
**HpaBC**  
Two-component flavin-dependent monooxygenase, _hpaBC_  
HPP & hydroxyphenylpyruvate  
**IcdA**  
isocitrate dehydrogenase, _icdA_  
**IEM**  
isoeugenol monooxygenase, _item_  
**Lac**  
laccase  
lipin peroxidase  
**LuxS**  
S-ribosylhomocysteine lyase, _luxS_  
**MARE**  
minimal aromatic aldehyde reduction ability  
**Met**  
methionine  
**MetE, MetH**  
methionine synthases, _metE, metH_  
**MetJ**  
transcription regulator of methionine biosynthetic gene cluster, _melf_  
**MetK**  
SAM synthetase, _metK_  
**MnP**  
manganese-dependent peroxidase  
**Mtn**  
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, _mtn_  
**OMT**  
O-methyltransferase transferase, _OMT, comt_  
PAD & phenolic acid decarboxylase, _pad_  
**PAL**  
phenylalanine ammonia-lyase, _PAL_  
**PCA**  
protocatechuric acid  
**PcaHG**  
protocatechuate dioxygenase, _pcaHG_  
**PDC1**  
pyruvate decarboxylase  
**PEP**  
phosphoenolpyruvate  
**PET**  
polyethylene terephthalate  
**PhdB**  
HMPHP-CoA dehydrogenase, _phdB_  
**PosSc**  
cytosol-recloalised NADH kinase, _pos5c_  
**PDDO**  
phenylpropanol 2,3-dioxygenase  
**PpsA**  
phosphenolpyruvate synthase, _ppsA_  
**PTase**  
phophopentetheinyl transferase, _entD, fgp, PPT_  
**Pta**  
phosphotransferacetylase, _pta_  
**PtsH**  
phosphocarrier protein, _ptsH_  
**Pyr**  
pyruvate  
**RARE**  
reduced aromatic aldehyde reduction ability  
**ROS**  
reactive oxygen species  
**SAH**  
S-adenosylyl-L-homocysteine  
**SAM**  
S-adenosylyl-L-methionine  
**SerA**  
phosphoglycerate dehydrogenase, _serA_  
**SRH**  
S-ribosyl-L-homocysteine  
**TA**  
terephthalatic acid  
**TAL**  
ammonia-lyase activity, _sam8_  
**Tkta**  
transketolase, _tktA_  
**TPADO**  
TA 1,2-dioxygenase, _tphA1, tphA2, tphB2_  
**Trp**  
tryptophan  
**UDP**  
uridine-diphosphate activated sugar  
**UGT**  
UDP-glycostransferase  
**VAO**  
vanillyl alcohol oxidase, _vao, pchF_  
**VDC**  
vanillate decarboxylase, _vdcBCD_  
**VDH**  
vanillin dehydrogenase, _vdh_  
**VDM**  
vanillate demethylylase, _vamAB_  
**VpVAN**  
vanillin synthase, _VvpVan_  
**VR**  
vanillin reductase, _vr_  
**Xfpk**  
phosphoketolase, _xfpk_  
\(\beta\)-Gluc**  
\(\beta\)-glucosidase  
* (28) [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON]; [PERSON] _Arabidopsis_ REF8 Gene Encodes the 3-Hydroxylase of Phenylpropanol Metabolism.