## 4 Discussion
\begin{table}
\begin{tabular}{c c c c c c c c c c} \hline \hline \multirow{2}{*}{**Model**} & \multirow{2}{*}{**R**} & \multirow{2}{*}{**R**} & \multirow{2}{*}{**Adjusted R**} & \multirow{2}{*}{**Std. Err. of the Estimate**} & \multicolumn{6}{c}{**Change Statistics**} \\ \cline{5-10}  & & & & & **R Square** & \multicolumn{1}{c}{**R Square**} & \multirow{2}{*}{**F Change**} & \multirow{2}{*}{**df1**} & \multirow{2}{*}{**df2**} & **Sig. F** \\  & & & & & & **Change** & & & **Change** \\ \hline
1 & 0.267 [FOOTNOTE:]Footnote : Predictors: (Constant), age, \(\mathrm{b}\) Predictors: (Constant), age, BMI, \(\mathrm{c}\) Predictors: (Constant), age, BMI, SAS. \(\mathrm{d}\) Predictors: (Constant), age, BMI, SAS, \(\mathrm{d}\) Predictors: (Constant), age, BMI, SAS, AHI/h.[ENDFOOTNOTE] & 0.071 & 0.056 & 2.64734 & 0.071 & 4.76 & 1 & 62 & 0.033 \\
2 & 0.389 [FOOTNOTE:]Footnote : Predictors: (Constant), age, \(\mathrm{b}\) Predictors: (Constant), age, BMI, \(\mathrm{c}\) Predictors: (Constant), age, BMI, SAS, \(\mathrm{d}\) Predictors: (Constant), age, BMI, SAS, AHI/h.[ENDFOOTNOTE] & 0.151 & 0.123 & 2.55145 & 0.08 & 5.748 & 1 & 61 & 0.02 \\
3 & 0.398 [FOOTNOTE:]Footnote : Predictors: (Constant), age, \(\mathrm{b}\) Predictors: (Constant), age, BMI, \(\mathrm{c}\) Predictors: (Constant), age, BMI, SAS, \(\mathrm{d}\) Predictors: (Constant), age, BMI, SAS, AHI/h.[ENDFOOTNOTE] & 0.158 & 0.116 & 2.56184 & 0.007 & 0.506 & 1 & 60 & 0.48 \\
4 & 0.437 [FOOTNOTE:]Footnote : Predictors: (Constant), age, BMI, \(\mathrm{c}\) Predictors: (Constant), age, BMI, SAS, \(\mathrm{d}\) Predictors: (Constant), age, BMI, SAS, \(\mathrm{d}\) Predictors: (Constant), age, BMI, SAS, AHI/h.[ENDFOOTNOTE] & 0.191 & 0.136 & 2.53294 & 0.033 & 2.377 & 1 & 59 & 0.128 \\ \hline \hline \end{tabular}
\end{table} 
Table 3: Multivariate analysis of corneal biomechanical parameters. 2013, 27% [PERSON] et al., 2008 to 30%--[PERSON] et al. 2019 [1, 11]. There are several types of glaucoma, but those associated with SAS are: normal pressure glaucoma and primary open-angle glaucoma [1, 8, 12]. The connection between SAS and glaucoma has been confirmed over time by several studies, which investigated several glaucoma-specific ocular parameters, including increased IOP, peripapillary RNFL thinning, visual field impairment, glaucomatous changes of the optic nerve [11] [PERSON] et al. stated that patients who do not have glaucoma but have SAS may develop glaucoma if SAS is not well controlled. Thus, strict control of this condition can contribute to a better management of glaucoma and stabilization of visual fields [11, 12, 13, 14]. In 2019, [PERSON] et al. [13] conducted a study to evaluate the RNFL and complex in patients with SAS, which confirmed that 40% of retinal ganglion cells axons are already lost before the occurrence of visual field defects. In a study that included more than 800 subjects aged 19-22, of which 150 had different types of SAS vs. healthy subjects assessing the OCT RNFL, [PERSON] et al. showed a preclinical thinning of RNFL in young subjects, suggesting an increased risk of glaucoma, which may already be present in young adults with OSA. Following this study, they concluded that patients diagnosed with SAS had an increase in RNFL of approximately 4 \(\upmu\)m (especially in the intratemporal and supratemporal segments), compared to the control group [14]. The change in the thickness of RNFL was also highlighted by [PERSON] et.al and [PERSON] et al. [15, 16] in patients who had a severe type of SAS compared to the control group. In their studies, the authors referred to an early thinning in the RNFL the supero lateral sectors being most severely affected in SAS. RNFL thinning is a change found in early glaucoma, which may indicate an increased risk of SAS-associated glaucoma at an early age. [1]. In our study, depending on the sleep apnea syndrome, the average level of disk area in the study eye was lower in mild obstructive SAS and the most increased in severe mixed SAS.