## 3 Results
“Intact” n = 6, “Control” n = 11, “SRC” n = 5, “Ikk\(\beta\)” n = 4, “—the differences are significant compared to the Intact group, \(p\leq 0.05\), one-way ANOVA was followed by Bonferroni post-hoc test for multiple comparisons. (**A**)—Time in the center—no statistically significant differences, F(3,20) = 0.9635, \(p\) = 0.4469; (**B**)—Distance in the center—no statistically significant differences, F(3,20) = 1.7625, \(p\) = 0.1867; (**C**)—Total distance, no statistically significant differences, F(3,20) = 1.4155, \(p\) = 0.2649; (**D**)—Number of stances, F(3,20) = 7.9602, \(p\) = 0.0011, Bonferroni post-hoc test for multiple comparisons revealed significant differences between the following groups: Intact vs. Control \(p\) = 0.0005. \begin{table}
\begin{tabular}{c c c c} \hline \hline
**Group** & \multicolumn{1}{c}{**Distance Covered before**} & \multicolumn{1}{c}{**Total Distance Covered, cm**} & \multicolumn{1}{c}{**Delayed Coefficient of**} \\  & **Platform Was Detected, cm** & & **Retention, \%** \\ \hline Intact (\(n=6\)) & 19.59 \(\pm\) 8.12 & 148.5 \(\pm\) 5.45 & 42.62 \(\pm\) 1.12 \\ Control (PBS) (\(n=12\)) & 29.42 \(\pm\) 8.67 & 132.2 \(\pm\) 6.55 & 29.48 \(\pm\) 2.15 * \\ SRC inhibitor (\(n=6\)) & 32.15 \(\pm\) 11.22 & 142.8 \(\pm\) 8.56 & 33.33 \(\pm\) 4.46 \\ IKK\(\beta\) inhibitor (\(n=6\)) & 31.46 \(\pm\) 10.01 & 141.2 \(\pm\) 6.86 & 33.28 \(\pm\) 2.26 \\ \hline \hline \end{tabular}  
*—the differences are significant compared to the Intact group, one-way ANOVA was followed by Bonferroni post-hoc test for multiple comparisons. Distance covered before platform was detected—no statistically significant differences F(3,20) = 1.7344, \(p\) = 0.8921. Total distance covered—no statistically significant differences, F(3,20) = 2.0574, \(p\) = 0.1381. Delayed coefficient of retention F(3,20) = 5.1521, \(p\) = 0.0084, Bonferroni post-hoc test for multiple comparisons revealed significant differences between the following groups: Intact vs. Control \(p\) = 0.0054.  
\end{table} 
Table 3: The main parameters of testing of experimental animals in the Morris water maze in postischemic period. Thus, inhibition of SRC kinase increased the animals' resistance to hypoxic and ischemic damage and supported their muscle abilities. In contrast, the use of an IKK\(\beta\) kinase inhibitor negatively affected the survival rate of animals in AHH and ischemia modeling. Histological samples were analyzed to study the dynamics of morphological changes in the brain tissue. The nervous tissue of intact animals was normal. The cells had a round or oval shape; the membrane had no ruptures; the cell diameter was 5.2 \(\pm\) 0.6 \(\upmu\)m, nuclear diameter was 2.2 \(\pm\) 0.3 \(\upmu\)m. The nuclei had an elongated oval shape, clearly defined. The cytoplasm of the cells was homogeneous, the contours of the cells were even, and the processes were quite numerous. During the study of the morphology of the sensorimotor cortex and the region of the ventricles of the brain, when modeling hypoxia as a factor of ischemia and ischemic damage, pronounced changes were observed (Figure 6). There was an expansion of the pericapillary spaces and hyperchromic neurons (small clusters of two to three cells in 10 fields of view). Tissue edema was pronounced. A significant part of the cells had an irregular shape with uneven contours; nuclear pycnosis was noted (about five cells in 10 fields of view). The cell size and nuclear diameter increased compared to the Intact group and was 8.0 \(\pm\) 0.9 and 4.4 \(\pm\) 0.6 \(\upmu\)m, respectively (Table 4). The group with blockade of SRC kinase showed slight morphological changes when modeling AHH relative to the Control. Near the inflammation focus, there were few altered neurons. Moreover, there were cells with distinct nucleus and soma contours (10 \(\pm\) 1.5%). Figure 6: Representative microphotographs of histological preparations of the cerebral cortex of mice in the modeling of acute hypobaric hypoxia. (**A**)—Intact, (**B**)—Control, (**C**)—SRC inhibitor, (**D**)—IK\(\beta\) inhibitor.