## 3 Nanosized-Lipid-Based Drug Delivery Systems in Wound Healing
\begin{table}
\begin{tabular}{c c c c c c c} \hline \hline  & \multicolumn{2}{c}{**Properties**} & \multicolumn{2}{c}{**Administration**} & \multicolumn{2}{c}{**Effects**} & \multicolumn{1}{c}{**Refs.**} \\
**Drug Loaded in** & **PS = Particle Size (nm)** & **Experimental Design** & **Administration** & **Effects** & **Refs.** \\
**Lipid Nanoparticles** & **ZF = Zeta Potential (mV)** & **EE = Encapsulation Efficiency (\%)** & & & & \\
**Self Lipid** & **Nanoparticles (SLNs)** & & & & & \\ \hline  & & & & & Accelerated wound-healing process \\  & & & & & Increased amount of collagen \\  & & & & & deposition \\ \multirow{2}{*}{Chammolite oil} & \multirow{2}{*}{
\begin{tabular}{c} PS = 542.1 \(\pm\) 27.5 \\ ZP = \(-\)35.9 \(\pm\) 0.602 \\ \end{tabular} } & \multirow{2}{*}{In vivo} & Adult male Wistar rats & \multirow{2}{*}{Topically} & \multirow{2}{*}{Significantly increased level of} \\  & & & & TGR-Retail \\ \hline  & & & & Stimulated the proliferation of \\  & & & & fibroblasts and keratinocytes \\ \hline  & & & & & \\  & & & & & \\ \multirow{6}{*}{L13/7 and Serpin A1} & \multirow{6}{*}{In vivo} & Bj fibroblasts & 3 mg/mL LI37-A1-SLNs & Faster cell migration and increased \\  & & Primary human & 5 mg/mL blank SLNs & wound closure for LI37 and Serpin \\  & & epidermal keratinocytes & 55 ug/mL LI37 only & A1 incorporated in SLNs \\  & & & 20 mg/mL AI & Overall compared collagen type I production \\ \cline{2-6}  & & & & 2 mg/mL LI37 and Serpin \\ \cline{2-6}  & & & Evaluation of the & \multicolumn{2}{c}{An encapsulated in SLNs} & The combination LL37 and Serpin A1 \\ \cline{2-6}  & & & & 5 ug/mL LI37 & had a synergistic antibacterial activity, \\ \cline{2-6}  & & & 20 mg/mL Serpin A1 & especially against 5. _ans_ and _E. coli_ \\ \cline{2-6}  & & & & & \\ \cline{2-6}  & & & Female New Zealand & \multirow{2}{*}{10 mg/mL LI37-A1-SLNs} & \multirow{2}{*}{Higher deposition of the drugs in the target area} \\  & & white rabbits: inner & & & \\ \cline{2-6}  & & & & & \\ \cline{2-6}  & & & & & \\ \cline{2-6}  & & & & & \\ \cline{2-6}  & & & & & \\ \cline{2-6}  & & & & & \\ \cline{2-6}  & & & & & \\ \hline \hline \end{tabular}
\end{table} 
Table 2: _Cont._  
\begin{table}
\begin{tabular}{c c c c c c c} \hline \hline \multicolumn{2}{c}{**Drug Loaded in Lipid Nanoparticles**} & \multicolumn{2}{c}{**Properties**} & \multicolumn{2}{c}{**Properties**} & \multicolumn{2}{c}{**Organication**} & \multicolumn{2}{c}{**Organication**} \\ \cline{3-6}
**Drug Loaded in Lipid Nanoparticles** & **PS = Particle Size (nm)** & **ZF = Zeta Potential (mV)** & **Experimental Design** & **Administration** & **Effects** & **Refs. ** \\  & **EE = Encapsulation Efficiency (\%)** & & & & & \\ \hline Nanostructured lipid carriers (NLCs) & & & Raw 264.7 cells & 10 \(\mu\)M & Anti-inflammatory potential \\ \hline \multirow{4}{*}{20(S)-protopnaxadol  
\begin{table}
\begin{tabular}{c c c c c c c} \hline \hline  & \multicolumn{2}{c}{Properties} & & & & \\
**Drug Loaded in** & **PS = Particle Size (nm)** & **ZF = Zeta Potential (mV)** & **Experimental Design** & **Administration** & **Effects** & **Refs. ** \\
**Lipid Nanoparticles** & **ZF = Zeta Potential (mV)** & **ZF = Encapsulation Efficiency (\%)** & & & & \\ \hline Nanostructured lipid & & & & & & \\ carriers (NLCs) & & & Human foreskin & & & \\ \hline  & & & & & & \\  & & & & & & \\  & &  
\begin{table}
\begin{tabular}{c c c c c c c} \hline \hline  & \multicolumn{2}{c}{**Properties**} & & & & \\
**Drug Loaded in** & **PS = Particle Size (nm)** & **Experimental Design** & **Administration** & **Effects** & **Refs. ** \\
**Lipid Nanoparticles** & **ZF = Zeta Potential (mV)** & **EE = Encapsulation Efficiency (\%)** & & & & \\ \hline Nanostructured lipid & & & & & \\ carriers (NLCs) & & & & & \\ \hline  & & & & & \\ \multirow{4}{*}{Peppermit essential oil} & \multirow{4}{*}{ \begin{tabular}{c} \(\mathrm{PS}=40\)-250 \\ \(\mathrm{ZF}=-10\) to \(-15\) \\ EE = \(93.2\pm 1.2\) \\ \end{tabular}  } & \multirow{4}{*}{ \begin{tabular}{c} In vivo \\ \(\mathrm{ZF}=93.2\pm 1.2\) \\ \end{tabular}  } & \multirow{4}{*}{