## 3 Observations and Analysis
### Serious Games for Affective Disorders  
There were five different types of affective disorders that were investigated in the selected studies. Almost all of them were investigated solely as well as being comorbid with other affective disorders and their distributions among the selected studies are shown in Figure 2. Table 2 shows the names and characteristic details of the games that had been applied as a therapeutic intervention or to mediate therapeutic interventions for autistic or neurotypical patients with affective disorders in the reviewed studies. There were 21 different games utilized in the reviewed studies, which were 'MindLight', 'Neuro Racer', 'Pegasas VR', 'ACT RAGE-Control', 'Vrelax', 'Tetris', 'Bear Blast', 'BIPOLIFE', 'Plants vs. Zombie', 'VIMSE', 'Space Academy', 'Dance Central', 'Hit the Cancer', 'Pesky Gnats: The Feel Good Island', 'Claustrophobia Game', '0 Phobia', 'Flowy', 'Maya', 'Processing Speed Training Game', 'Wii Sports Gaming Package', 'New Horizon and SpaceControl'. The most frequently used game was a neurofeedback third-person adventure game called 'MindLight' (5 out of 37) [35; 49; 55; 62; 64] and this was also the most often used game for anxiety therapy, among others such as 'New Horizon and Space Control' (2 out 37) [63; 67]. There were some other games as well for other forms of anxiety, for instance, the puzzle game 'Tetris' was used for PTSD symptom mitigation [40; 45] and the therapeutic VR game 'Pegasas VR' was used for therapy of social anxiety disorder [34]. Moreover, there were other games that were used for therapy when anxiety was comorbid with other affective disorders, for instance, the therapeutic VR game 'Vrelax' for therapy for depressive, bipolar and anxiety disorders [39], the third person adventure game 'Pesky Gnats: The Feel Good Island' [52] and the first person shooter game 'Hit the Cancer' [51] for anxiety and depression. Among these games, 'MindLight' [62; 64], 'New Horizon and Space Control' [63; 67] and three other unnamed games [65; 66; 68] were used for interventions for participants with ASD while the rest were utilized as interventions for neurotypical participants [33; 34; 35; 36; 37; 38; 39; 40; 41; 42; 43; 44; 44; 45; 46; 47; 48; 49; 51; 53; 54; 55; 56; 57; 58; 59; 60; 61; 62; 63; 64; 65; 66; 67; 68; 69; 70; 71; 72; 73; 74; 75; 76; 77; 78; 79; 80; 81  
Four different games were utilized for therapy against different types of phobias, two of them were named in the studies, namely the therapeutic VR game 'VIMSE' for spider phobia [46] and the action-exploration VR game '0 Phobia' for acrophobia [54]. Three games were utilized for phobias/fear disorders being comorbid with other affective disorders and the only game that was comorbid with an ailment other than an affective disorder among these was the exergame 'Dance Central' (for depression and fear of falling) [50]. The most frequently used game for depression therapy was the racing game 'Neuro Racer' (3 out of 37) [37; 56; 98] followed by a first-person role-playing adventure game 'Maya' [59] and a set of puzzle games 'Processing Speed Training Games' [60]. Some other games were utilized for some forms of depression, for instance, the exergame 'Wii Sports Gaming Package' for subsyndromal depression [61] and the action-shooter game 'Plants vs. Zombies' for recurring depression [44]. In the studies reviewed for this paper, depression was found to be comorbid with anxiety, phobias, and one instance of bipolar disorder. The games utilized for those studies have already been discussed above. There was only one study that investigated therapy with a serious game solely for bipolar disorder, which utilized the web-based social simulation 'BIPOLIFE' [42]. The only other disorder for which a serious game intervention was investigated among the selected studies was emotion dysregulation of anger and aggression; the game utilized for that study was the isometric action game 'ACT RAGE-Control' [36].