## 1 Introduction  
The surgical extraction of the mandibular third molar is one of the most frequent oral surgical procedures performed in dental clinics. Several postoperative complications have been reported including pain, edema, trismus, and/or functional limitation. These complications may eventually have an impact on the patient's quality of life [1]. The postoperative patient discomfort might be due to triggering an inflammatory response [2]. Pain represents the major postoperative problem, as it may affect 20-40% of patients. The most intense pain is predicted in the first 12 h after surgery and may endure up to between the third and fifth day after surgery at a lower intensity [3]. The use of anti-inflammatory agents, including non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids, has been shown to be efficient in the management of these postoperative complications in general and pain in particular [2,4]. However, there are many reported side effects of the use of these drugs, such as gastrointestinal irritation, allergic reactions,or hemorrhagic complications. In addition, these drugs should be avoided in certain conditions for some patients [5]. Several modifications and improvements in surgical procedures have been proposed as a trial to decrease surgical trauma and, eventually, postoperative discomfort, such as the use of piezosurgery, surgical closure techniques with/without the placement of a drain, cryotherapy, the use of platelet-rich fibrin, and photobiomodulation (PBM) [6; 7; 8; 9; 10; 11]. PBM is the application of non-ionizing forms of light by utilizing the impact of light energy on living cells for therapeutic purposes. This application may modulate, restore, and stimulate physiological processes, which may eventually lead to the repair of damages caused by injuries or diseases [12]. PBM can induce several physiological pathways, resulting in anti-inflammatory, analgesic, and bio-modulatory effects. Therefore, PBM has been proposed as an adjunctive modality in the management of many medical and dental conditions, such as oral mucositis, oral lichen planus, medication-related osteeonecrosis of the jaw, and temporomandibular joint disorders [13; 14; 15; 16; 17]. PBM has been widely investigated as an adjunctive modality to the surgical procedure of the extraction of the impacted third molar [11; 18; 19]. Several meta-analyses and systematic reviews have been conducted in recent years to evaluate the effectiveness of the PBM and determine the best effective protocols [20; 21; 22; 23; 24]. In the literature, it appears that the level of the effectiveness of PBM has grown through the years with the performance of studies, as [PERSON] et al. in 2012 and then [PERSON] et al. in 2017 did not observe any positive effect of PBM with third molar surgery [20; 21]. In 2021, [PERSON] et al. observed, by adding the new studies to the previous systematic metastases, the effectiveness of PBM for swelling but not for pain and trismus [22]. In the same year (2021), [PERSON] et al. reported in their meta-analysis the effectiveness of PBM for the reduction in pain and edema but not for trismus [23]. Recently, [PERSON] et al. reported, in 2023, the effectiveness of PBM for the reduction in all pain, swelling, and trismus. However, they found that PBM's level of evidence still ranges from low to very low in a way meaning that PBM cannot be considered a routine practice with third molar surgery [24]. They recommended using the combined protocols of PBM (intraoral and extraoral) rather than only the intraoral or extraoral protocol [24]. Most of the wavelengths used for PBM in the studies included in these systematic reviews were red and near-infrared wavelengths [20; 21; 22; 23; 24]. All of these systematic reviews recommended conducting further studies in order to determine the effective PBM protocols [20; 21; 22; 23; 24]. In addition, to the best of our knowledge, there is no study that evaluates PBM application using a combination of different wavelengths.