## 3 Results  
### Search Results and Studies Selection  
The pre-established document search strategy initially yielded 305 results. After the removal of duplicates, the search yielded 251 results. Following evaluation of titles and abstracts, this number was narrowed to 129 documents. Subsequently, an additional 41 documents were excluded because they did not focus on the treatment or recurrence of the lesions, including some studies that did not include a retrospective analysis of treatment outcome and others that did not meet the inclusion criteria for the clinical and histopathological characteristics of the lesions. At the end of the study selection process, 59 documents were considered suitable for review (Figure 1). Figure 1: Flowchart systematic review. At the end of the selection process, the studies were divided according to the type of treatment into pharmacological and non-pharmacological therapies (Table 1). A summary of all studies included was compiled. For each treatment found in the literature, the following parameters were examined (Tables 2-12):  
* Type of treatment and study (authors and year);
* Dosage and therapy administration;
* Number of patients;
* Type of benign lesion;
* Treatment length;
* Follow-up length;
* Presence of recurrence;
* Side effects;
* Number of immunocompromised patients. \begin{table}
\begin{tabular}{c c c c c} \hline \hline
**Treatment** & \multicolumn{4}{c}{**Studies**} \\ \hline Imiquimod & [PERSON] et al., 2003 & [PERSON] et al., 2004 & [PERSON] [PERSON] et al., 2015 & \\ \hline Cidofovir & [PERSON] 2000 & [PERSON] et al., 2004 & [PERSON] et al., 2005 & [PERSON] et al., 2011 \\ \hline Bleomycin & [PERSON] et al., 2000 & & & \\ \hline Imidazoquinoline & [PERSON] et al., 2017 & & & \\ \hline Interferon & [PERSON] et al., 2001 & [PERSON] et al., 2001 & [PERSON] et al., 2003 (con CO\({}_{2}\)) & [PERSON] et al., 2009 (con laser) \\ \cline{2-5}  & NCT00454181, 2011 & & & \\ \hline Trichloracetic acid & [PERSON] et al., 2017 & & & \\ \hline \multicolumn{5}{c}{**Non-Pharmacological Treatment**} \\ \hline
**Treatment** & \multicolumn{4}{c}{**Studies**} \\ \hline Cryotherapy & [PERSON] et al., 2005 & & \\ \hline \multirow{4}{*}{Surgical excision Cold scalpel} & [PERSON] 2001 & [PERSON] et al., 2009 & [PERSON] et al., 2009 & [PERSON] et al., 2011 \\ \cline{2-5}  & [PERSON] et al., 2014 & [PERSON] et al., 2014 & [PERSON] et al., 2015 & [PERSON] et al., 2016 \\ \cline{2-5}  & [PERSON] et al., 2018 & [PERSON] et al., 2018 & [PERSON] et al., 2018 & [PERSON] et al., 2019 \\ \cline{2-5}  & [PERSON] 2019 & & & \\ \hline Electrosurgery & [PERSON] et al., 2003 & [PERSON] et al., 2012 & [PERSON] et al., 2014 & [PERSON] 2019 \\ \hline \multirow{4}{*}{Surgical excision Laser} & [PERSON] et al., 1990 & [PERSON] et al., 1992 & [PERSON] et al., 1999 & [PERSON] et al., 2000 \\ \cline{2-5}  & [PERSON] et al., 2001 & [PERSON] et al., 2002 & [PERSON] et al., 2003 & [PERSON] et al., 2004 \\ \cline{2-5}  & [PERSON] et al., 2005 & [PERSON] et al., 2007 & [PERSON] et al., 2009 & [PERSON] et al., 2009 (con interference) \\ \cline{2-5}  & [PERSON] et al., 2010 & [PERSON] 2013 & [PERSON] et al., 2014 & [PERSON] 2015 \\ \cline{2-5}  & [PERSON] et al., 2018 & & & \\ \hline Mohs micrographic surgery & [PERSON] et al., 2006 & & & \\ \hline Follow-up (after incisional biopsy) & [PERSON] et al., 1996 & [PERSON] et al., 2004 & [PERSON] et al., 2009 & [PERSON] et al., 2010 \\ \hline \hline \end{tabular}
\end{table} 
Table 1: Studies included.