# Biocompatibility of Membranes Based on a Mixture of Chitosan and _Lythri herba_ Aqueous Extract  
[PERSON]  
1 Faculty of Pharmacy, Ovidius University of Constanta, 9004070 Constanta, Romania; [EMAIL_ADDRESS] (M.I.L. ); [PERSON]L_ADDRESS]om (A.H.); [EMAIL_ADDRESS] (V.I. ); [EMAIL_ADDRESS] (L.A.B. ); [EMAIL_ADDRESS] (G.M. ); [EMAIL_ADDRESS] (G.A.-P)  
[PERSON]  
1 Faculty of Pharmacy, Ovidius University of Constanta, 9004070 Constanta, Romania; [EMAIL_ADDRESS] (M.I.L. ); [PERSON]SS] (A.H.); [EMAIL_ADDRESS] (V.I. ); [EMAIL_ADDRESS] (L.A.B. ); [EMAIL_ADDRESS] (G.M. ); [EMAIL_ADDRESS] (G.A.-P)  
[PERSON]  
1 Faculty of Pharmacy, Ovidius University of Constanta, 9004070 Constanta, Romania; [EMAIL_ADDRESS] (M.I.L. ); [PERSON]SS] (A.H.); [EMAIL_ADDRESS] (V.I. ); [EMAIL_ADDRESS] (L.A.B. ); [EMAIL_ADDRESS] (G.M. ); [EMAIL_ADDRESS] (G.A.-P)  
[PERSON]  
1 Faculty of Pharmacy, Ovidius University of Constanta, 9004070 Constanta, Romania; [EMAIL_ADDRESS] (M.I.L. ); [PERSON]SS] (A.H.); [EMAIL_ADDRESS] (V.I. ); [EMAIL_ADDRESS] (L.A.B. ); [EMAIL_ADDRESS] (G.M. ); [EMAIL_ADDRESS] (G.A.-P)  
[PERSON]  
1 Faculty of Pharmacy, Ovidius University of Constanta, 9004070 Constanta, Romania; [EMAIL_ADDRESS] (M.I.L. ); [PERSON]SS] (A.H.); [EMAIL_ADDRESS] (V.I. ); liuarbaucur@univ-ovidius. properties intended for the food packaging industry [12] and on advanced biomaterials for pharmaceutical or biomedical fields [9; 13; 14; 15]. Consequently, emphasis is placed on the mass production of natural, non-toxic, biodegradable, eco-friendly, easy to procure and relatively cheap materials, such as gelatin [16; 17], chitosan [18; 19; 20], chitin [21; 22], collagen [23; 24] and cellulose [25; 26], in order to achieve diverse biomedical, environmental and food applications. One such material, chitosan, is a cationic biopolymer indispensable in its use as a carrier of therapeutic substances [27; 28] due to its non-toxic, biodegradable, biocompatible, antibacterial and antioxidant nature [29]. Chitosan, a biopolymeric macromolecule, possesses a multitude of technical and biological properties that have gained significant attention in diverse global research, in particular concerning biomedical healing applications that require anti-microbial and anti-inflammatory capacities [30; 31; 32; 33; 34; 35; 36]. At the same time, attractive aspects were analyzed for various fields in the food, cosmetic, medical and pharmaceutical industries, such as the abundant availability and low cost of chitosan, which falls within the general desideratum of obtaining materials through renewable green resources [37; 38]. In addition, an important property of chitosan is its uncoadhesiveness as a result of its ability to interact with negatively charged mucins through electrostatic attraction [39], since this biopolymer is the only positively charged polysaccharide in the world due to the presence of amino groups in its chemical structure [38]. Moreover, chitosan is known as a hemostatic agent in the pharmaceutical industry for the formulation of wound dressings due to its affinity for red blood cells and its ability to induce clotting. Although chitosan is widely used in the fields of biotechnology, wastewater treatment, agriculture, the food industry, cosmetics, medicine and pharmacy for its unique properties, it has some limitations in the biomedical field caused by its poor solubility and inferior mechanical properties [40; 41]. The solubility issue can be improved through structural modifications, thereby creating novel derivatives with superior physical properties, broadening its application range [41]. Some of the most recent studies evaluate chitosan-based membranes in which plant extracts [42] or their secondary metabolites [43; 44] have been incorporated, precisely due to the superior ability of chitosan to form membranes [45; 46; 47]. An underestimated traditional medicinal plant rich in bioactive compounds (polyphenols, tannins) is the _Lythrum salicia_ L. species.