## 1 Introduction
Among other things, the high oxidation efficiency of such drugs as paracetamol, metenamic acid, and diclofenac by immobilized lacases was demonstrated, which, after immobilization on polyvinylidene fluoride membrane, were highly stable in sewage conditions at variable temperatures and pH [13; 14]. However, the use of enzymes has its drawbacks, one of the most important of which is the need to isolate the enzyme, which increases the cost of the bioremediation process. Hence, it is more economical to use immobilized whole bacterial cells [12]. [PERSON] et al. [15] successfully used an immobilized bacterial consortium on activated carbon to remove pyrene-Cr(VI) from contaminated soil. In turn, [PERSON] et al. [16] demonstrated the effectiveness of immobilized bacteria on ground cinnamon shells in decomposing seawater-polluting diesel. It was indicated that introducing an immobilized bacteria to the system increased the phosphorus and nitrogen content and promoted the growth of oil-degrading bacteria [16]. Significant for technological processes, apart from the ability of microorganisms to decompose a larger group of drugs, is their resistance to the presence of co-contaminants. It was shown that a mixture of drugs could significantly affect the degradation rates of each of them. In addition, compounds such as alcohols, phenols, organic solvents, or heavy metals can considerably reduce the degradation capacity of introduced strains [11; 17; 18]. Among others, [PERSON] et al. [11] showed inhibition of the degradation of ibuprofen, diclofenac, and naproxen in the presence of 2-nitrophenol. In turn, copper inhibited the decomposition of paracetamol and diclofenac, and in the presence of acetone, the decomposition of paracetamol, naproxen, and diclofenac was inhibited. In addition, a synergistic effect of the drugs themselves on the microorganisms that decompose them is often observed. For example, _Bacillus thuringiensis_ B1(2015b) showed the ability to degrade 10 mg/L of ibuprofen within 24 h, while the same concentration of the drug administered in a bioreactor with a mixture of naproxen, diclofenac, and paracetamol was degraded within 3 days [11; 19]. In previous studies, the authors successfully immobilized strains capable of degrading selected NSAIDs on the plant sponge _Luffa cylindrica_ and characterized their properties [20; 21; 22; 23]. The choice of plant sponge from _Loofah cylindrica_ was dictated by the fact that it is a cheap, biodegradable, and biocompatible material with a hydrophilic surface on which there are many functional groups. The main advantages of this material are high porosity, non-toxicity, simple application and operation technique, and mechanical resistance [20]. The current work continues research aimed at developing an optimized preparation for the degradation of a mixture of NSAIDs and paracetamol. The specific objectives were the selection of appropriate bacterial ratios and the amount of carrier. To determine the effectiveness of the preparation in the presence of co-contaminants, the degradation of the mixture of NSAIDs and paracetamol in the presence of various phenol concentrations was tested.