## 1 Introduction  
The process of tissue repair, regardless of the stimulus of the damage, involves highly coordinated, physiological, time-stretched, systemic responses. Irregular progression of the regeneration process leads to the development of chronic wounds, necrosis, or exaggerated scarring. Some disorders necessitate the assistance of dressings, particularly those possessing biodegradable, non-immunogenic properties, in the course of damaged tissue recovery. The forementioned special type of dressing constitutes an indispensable component of healthcare, playing a vital role in burn injury treatment [1]. Electrospun polymer nanofiber dressings are intended not only to protect the wound against the influence of the external environment but also to support the process of regeneration of damaged tissue [2]. The dressings in question allow both air and body fluids to flow into the wound, while blocking the access of microorganisms. In order to shorten the regeneration time of the damaged tissues, nanofibers with the addition of active substances are used [3]. An example of a substance of natural origin used in apitherapy is bee glue, i.e., propolisis, in addition to honey, pollen, bee bread or royal jelly [4]. Among bee products, propolisis is the most biologically active substance. Most reports in the literature regarding the discussed apitherapeutic agent focus on determining its chemical composition, as well as describing the antibacterial, antiviral, antifungal, antioxidant and anticancer activities of its extracts [4; 5; 6; 7]. The mentioned properties of propolisis also include regenerative and reparative effects (also on post-burn wounds) through the influence on the components of the extracellular matrix (ECM), i.e., glycosaminoglycans (GAGs), collagen, fibronectin, laminin and vitronectin. The ECM plays a crucial role in tissue integrity restoration, involving the coordinated action of various cells, including neutrophils, macrophages, fibroblasts, and epithelial and endothelial cells. These cells interact with ECM components through integrin receptors and adhesion molecules. During the repair process, ECM components form a temporary matrix, facilitating cellular adhesion, migration, differentiation, and proliferation. Additionally, ECM components regulate the organization and metabolism of the matrix itself. GAGs and proteoglycans (PGs) within the ECM bind with high affinity to cytokines, growth factors, and chemokines, thus playing a significant role in signal transduction. Changes in ECM composition during repair can affect reepithelialization, basement membrane regeneration, and intercellular communication. Understanding these mechanisms is pivotal for developing new therapeutic strategies in wound healing processes [8; 9; 10; 11; 12; 13]. The recovery of thermal tissue injuries encompasses four overlapping \"events\", including the hemostasis stage, inflammatory stage, proliferation stage, and maturation stage. Hemostasis occurs immediately after injury, where blood vessels restrict and clotting mechanisms are activated to prevent excessive bleeding. This is followed by the inflammation phase, characterized by the infiltration of immune cells such as neutrophils and macrophages, which work to remove debris and pathogens from the wound site. The proliferation phase then ensues, marked by the formation of granulation tissue, angiogenesis, and re-epithelialization. During this stage, fibroblasts play a critical role by synthesizing ECM components like collagen, which provide structural support for new tissue formation. Finally, the remodeling phase involves the maturation and reorganization of collagen fibers, leading to increased tensile strength of the healed tissue and restoration of normal skin architecture. Throughout these stages, the ECM not only provides a scaffold for cellular activities but also regulates various signaling pathways crucial for effective wound healing [14].