## 1 Introduction  
Sterility inspection plays an important role in controlling food and drug quality for enterprises and regulatory agencies inspecting qualified products. Therefore, the requirements of sterility tests are clearly listed in the latest 2011 GMP (Good Manufacturing Practice for Pharmaceuticals) [1; 2; 3], the 2015 Chinese Pharmacopoeia and the United States pharmacopoeia USP31-NF26 \"71\" etc. [4; 5] editions. The sterility test of the samples can adopt the membrane filtration method and the direct inoculation method. Conventionally, the sterility inspection relies on manual operations, which have low automation and intelligence levels, leading to low efficiency. The key processes of sterility inspection will be greatly affected by personnel. It is possible that there are significant differences in sterility inspection results and efficiency due to the operations of different personnel. Therefore, it is imperative to improve intelligence levels through the automatic design and operation. For the ampoule bottle filled with the test samples, its automatic opening is key to the operation of the sterility inspection. The process of an automatic opening of an ampoule bottle includes cutting and breaking steps. The cutting aims to produce a non-penetrating crack, avoiding glass fragments breaking and then entering the ampoule bottle to contaminate the samples. The ampoule bottle is made from the glass, which has high compressive strength, hardness and good elasticity at room temperature. In comparison to steel parts, plastics and building materials, the glass has a linear relationship between stress and strain. [PERSON] first proposed the theory of low stress brittle fracture of glass and established the fracture mechanics of glass [6; 7]. Since then, fracture mechanics has been used to study the fracture behavior of the glass, which plays a crucial role in the use of the glass. [PERSON] et al. [8] studied the phenomenon of crack healing and its relationship with glass transition and characterized the glass transition and explored the glass transition mechanism. [PERSON] et al. [9] conducted a systematic study on the fracture surface of brittle metallic glass under compressive load, proposed its fracture mechanism and provided a theoretical basis for the development of dynamic fracture of brittle metallic glass. [PERSON] [10] investigated the crack growth rate of the fracture of silicate glass and estimated the kinetic energy at the crack growth by using the strain energy release rate. [PERSON] et al. [11; 12] demonstrated the strain energy and fracture pattern morphology of thermally tempered glass and elaborated the relevant parameters that affect glass fracture. For different materials of glass, the fracture characteristics and mechanical properties will be different. The ampoule bottles are fabricated from high borosilicate glass. Compared with ordinary glass, high borosilicate glass has greater thermal stability, mechanical properties, acid and alkali resistance, and no toxic side effects. Therefore, it is widely used in various fields, such as chemical industry, household and medical treatment. During the opening of the ampoule bottle, the crack left by cutting the neck of ampoule bottle can be regarded as a semi-elliptical crack through observation and measurement. The initial crack is a non-penetrating three-dimensional crack; its width and depth are different because of the difference in initial incision. According to the geometric characteristics of cracks, the cracks can be divided into three types: penetration cracks, deep buried cracks and surface cracks. According to the mechanical characteristics of cracks, the cracks can be divided into type I cracks (open cracks), type II cracks (slide cracks), type III cracks (tear cracks) and compound cracks. In their actual conditions, most of the cracks are type I cracks [13].