## 2 Materials and Methods
The stimulating system is based on the stimulation of the above mechanism, in order to keep the optic nerve signal alive, avoiding or reducing the neurochemical phenomena related to ocular nervous fibres degeneration of the fibres of the ocular nerve. Therefore, we could consider effective the light stimulation if a slowing in the progression of the disease occurs, and the visual field, and the quality of vision, is maintained or improved. In order to obtain experimental evidence in relation to our thermodynamic results, useful for the definition of a more detailed trial on a large number of patients, and to design a possible future therapy, we have developed a first trial on a small set of patients, approved by our bio-ethic board. So, this operative study is focused on the achievement of two objectives specific for patients with pathologies concerning damage to the optic nerve resulting from primary chronic open-angle glaucoma:  
* Primary objective: to verify a reduction in the damage to the optic nerve, and a progressive recovery of vision, in patients undergoing rehabilitation therapy, based on visual stimuli;
* Secondary objective: to verify an improvement in the quality of life in enrolled patients. The criteria to enrol the patients can be summarised as follows:
* They are affected by a chronic open angle glaucoma;
* The damage is no more than the 50% of the vision field;
* They do not suffer any further disease. The number of patients suggested by the bio-ethic board was twelve white Italians, as reported in \[c_{N}=c_{N,0}\,\exp\left(\frac{N\,e_{N}}{k_{B}\,T}\right) \tag{2}\]1 All the patients enrolled continued their pharmacological treatments. All the patients were enrolled after an ophthalmic visit and anamnesis of vision loss in certain areas. The quantitative technical diagnosis was obtained using Optic Computed Tomography (OCT). OCT is an imaging technique that uses low-coherence (or white light) interferometry to capture micrometer resolution, from within optical scattering media [47]. Ocular OCT is used by ophthalmologists to obtain high-resolution images of the retina and anterior segment [48]. It provides a straightforward method of assessing cellular organisation, photoreceptor integrity, and axonal thickness in glaucoma, macular degeneration, retinal nerve fibre layers (RNFL), etc. Since 1991, OCT has been improved by rapid evolution for use in detection and monitoring of glaucoma and macular diseases. Indeed, average RNFL thickness indicates patient overall RNFL health. The mean value for RNFL thickness in the general population is \(92.9\pm 9.4\)\(\upmu\)m [49; 50; 51; 52; 53]. Typically, a normal, non-glaucomatous eye has an RNFL thickness of 80 \(\upmu\)m or greater, and is represented by green colour in the OCT exam result. An eye with an average RNFL thickness of 70 \(\upmu\)m to 79 \(\upmu\)m is suspected of glaucoma, and is represented by yellow colour in the OCT exam result. OCT shows optic nerve hypoplasia (ONH) and RNFL parameters: RNFL and ONH parameters present a green colour code for normality, values below normality present a red colour code, and borderline values are represented by a yellow colour code. A white colour code refers to values above the normality range, and grey indicates that normative data are not applicable. Red colour represents the diseased thickness. All the patients undergo an optical computed tomography CIRRUS 5000 by [PERSON] (Oberkochen, Germany) scan prior to and after the complementary therapy. The treatment is realised by using the smartphones of the patients (Android OS, display Touchscreen, 6.3 in, pixels 2340 \(\times\) 1080). Python-based software generates the stimuli on the patient's smartphone screen. The software generates light circles which move randomly around the periphery of the area of visual loss: this is the treatment suggested. So, the moving circles appear on the screen, upon which the patients gaze must remain fixed.