# Identifying Terpenoid Biosynthesis Genes in _Euphoria maculata_ via Full-Length cDNA Sequencing
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3 BIT Institute, NBIT Co., Ltd., Chuncheon 24341, Korea; [EMAIL_ADDRESS]  
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4 On Biological Resource Research Institute, Chuncheon 2439, Korea; [EMAIL_ADDRESS]  
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3 BIT Institute, NBIT Co., Ltd., Chuncheon 24341, Korea; [EMAIL_ADDRESS]  
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1 Microorganism Resources Division, National Institute of Biological Resources, Incheon 22689, Korea; mi428 [EMAIL_ADDRESS] (M.J.J. ); [EMAIL_ADDRESS] (J.Y.O.) [PERSON]  
2 Agriculture and Life Sciences Research Institute, Kangwon National University, Chuncheon 24341, Korea; [EMAIL_ADDRESS] (N.S.R. ); [EMAIL_ADDRESS] (T.U.) [PERSON]  
3 BIT Institute, NBIT Co., Ltd., Chuncheon 24341, Korea; [EMAIL_ADDRESS]  
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4 On Biological Resource Research Institute, Chuncheon 24239, Korea; [EMAIL_ADDRESS]  
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5 Biological Resources Assessment Division, National Institute of Biological Resources, Incheon 22689, Korea; [EMAIL_ADDRESS]  
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3 BIT Institute, NBIT Co., Ltd., Chuncheon 24341, Korea; [EMAIL_ADDRESS]  
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4 On Biological Resource Research Institute, Chuncheon 2439, Korea; [EMAIL_ADDRESS]  
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3 BIT Institute, NBIT Co., Ltd., Chuncheon 24341, Korea; [EMAIL_ADDRESS]  
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4 On Biological Resource Research Institute, Chuncheon 2439, Korea; [EMAIL_ADDRESS]  
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3 BIT Institute, NBIT Co., Ltd., Chuncheon 24341, Korea; [EMAIL_ADDRESS]  
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4 On Biological Resource Research Institute, Chuncheon 2439, Korea; [EMAIL_ADDRESS]  
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3 BIT Institute, NBIT Co., Ltd., Chuncheon 24341, Korea; [EMAIL_ADDRESS]  
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4 On Biological Resource Research Institute, Chuncheon 2439, Korea; [EMAIL_ADDRESS]  
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3 BIT Institute, NBIT Co., Ltd., Chuncheon 24341, Korea; [EMAIL_ADDRESS]  
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4 On Biological Resource Research Institute, Chuncheon 24329, Korea; [EMAIL_ADDRESS]  
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3 BIT Institute, NBIT Co., Ltd., Chuncheon 24341, Korea; [EMAIL_ADDRESS]  
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4 On Biological Resource Research Institute, Chuncheon 24329, Korea; [EMAIL_ADDRESS]  
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3 BIT Institute, NBIT Co., Ltd., Chuncheon 24341, Korea; [EMAIL_ADDRESS]  
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1 Microorganism Resources Division, National Institute of Biological Resources, Incheon 22689, Korea; mi428 star@korea.lx (M.J.J. ); ohy21@korea.lx (J.Y.O.) [PERSON]  
2 Agriculture and Life Sciences Research Institute, Kangwon National University, Chuncheon 24341, Korea; [EMAIL_ADDRESS] (N.S.R. ); [EMAIL_ADDRESS] (T.U.) [PERSON]  
4 On Biological Resource Research Institute, Chuncheon 243341, Korea; [EMAIL_ADDRESS]  
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4 On Biological Resource Research Institute, Chuncheon 2439, Korea; [EMAIL_ADDRESS]  
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3 BIT Institute, NBIT Co., Ltd., Chuncheon 24341, Korea; [EMAIL_ADDRESS]  
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3 BIT Institute, NBIT Co., Ltd., Chuncheon 24341, Korea; [EMAIL_ADDRESS]  
Yoongcause skin irritation and rash in some people, extracts have been used to treat diarrhea, hemolysis, and hematuria [4]. There are numerous reports on the bioactive phytochemicals in _E. maculata_, such as polyphenols, tannins, flavonoid glycosides, and triterpenoids [4; 5; 6; 7]. Also known as isoprenoids, terpenoids are a large class of plant secondary metabolites with more than 50,000 naturally occurring members [8]. Terpenoids are organic compounds derived from a 5-carbon isoprene (C\({}_{5}\)) called isopentyl diphosphate (IPP). Terpenoids are synthesized by the head-to-tail addition of IPP (C\({}_{5}\)) units, resulting in hemiterpenoids (C\({}_{5}\)H\({}_{8}\)), monoterepenoids (C\({}_{10}\)H\({}_{16}\)), triterpenoids (C\({}_{20}\)H\({}_{32}\)), and triterpenoids (C\({}_{30}\)H\({}_{48}\)) [9]. There are two IPP biosynthesis pathways: the cytosolic mexulonic acid (MVA) pathway, resulting in IPP; and the plasidial methylerythitol phosphate (MEP) pathway, resulting in dimethylallyl diphosphate (DMAPP), an IPP isomer [10].