## 1 Introduction
Electrospun PLGA/gelatin (GE) membranes containing _Hypericum capitatum_ extract have been developed and their biocompatibility properties investigated [38]. A wound dressing was designed from zein polymer containing _Hypericum perforatum_ oil [39]. The cellulose-based fibrous dressing material for the treatment of acute wounds was produced from carboxymethyl cellulose (CMC)/poly (ethylene oxide) (PEO)/_Hypericum perforatum_ solutions by needle-free electrospinning method [40]. The production of PEO and chitosan (CS) based fibrous containing _Hypericum perforatum_ for wound dressings has been investigated [41]. A new wound dressing was fabricated by electrospinning using _Hypericum perforatum_ oil into a mixture of biodegradable PCL/GE blended polymers [42]. PLA is an aliphatic polyester that is biocompatible and biodegradable. The US Food and Drug Administration has approved PLA for clinical applications. These properties have made PLA-based materials suitable for biomedical applications such as sutures, bone fixation implants, stents, tissue engineering scaffolds, and drug delivery carriers [6; 18]. Researchers have been worked about the development antibacterial PLA-based electrospun materials using chitosan and silver [43], thymol [44], propolisis [45], silver and vitamin E [46], copaiba (_Copafera_ sp.) oil [47], tetracycline hydrochloride and chitosan [48], cinnamon essential oil [49], thymoquinone [50], tea tree and manuka oil [51], carvacrol [52], clary stage and black pepper [53], terpinen-4-ol [54], epidermal growth factor [55], quercetin [56],Nigella sativa herbal extract [57], Eucalyptus essential oil [58], silver diclofenac complex [59], chitosan, black pepper essential oil and limonene [60], selenium and clarithromycin [61], cefazolin [62], silver nanoparticles [63], zinc oxide [64], thyme essential oil [65], zenian (_Carum copticum_) essential oil [66], birch bark triterpene extract [67], _Carparis spinosa_ L. extracts [68], _Plumbago europaea_ plant extract [69], curcumin [70], babassu oil [71], and cypress (_Cupressus sempervirens_ L.) essential oil [72]. Despite all the efforts mentioned above, the effects of _Hypericum perforatum_ oil on the morphology of poly(lactic acid) electrospun mats have not yet been studied. PLA is easily available, biodegradable and renewable [1; 2; 3; 4; 5; 6]. _Hypericum perforatum_ oil exhibits bioactive properties such as antioxidant, anti-inflammatory, anticarcinogenic, and antifungal [30; 31; 32; 33]. Moreover, it is already widely used and accessible in the medical field. It has been proposed that developing an advanced material using a combination of the beneficial properties of _Hypericum perforatum_ oil and the advantages of poly(lactic acid) might be an alternative in bioengineering applications. This study contributes to the development of new sustainable materials and opens a new door to other studies. This research work aims to develop antimicrobial PLA-based nonwoven fabrics containing HPO using a simple, environmentally-friendly method. HPO/PLA nonwoven fabrics were fabricated by electrospinning HPO/PLA aqueous solutions. The morphology, chemical composition, thermal and physical properties of the electrospun nonwovens were investigated. The electrospun HPO/PLA nonwoven fabrics demonstrated good antibacterial activity and have the potential for use in a variety of biomedical applications, particularly wound dressing, due to the combination of the antibacterial activity of the HPO and the favorable biocompatible and biodegradable polymer due to the PLA fibers.