# Antibacterialativity of _Lysimachia nummularia_ L. in Oro-Dental Diseases
## 1 Introduction  
There are many biologically active compounds from plant extracts that have been shown to have antibacterial properties and can potentially help in developing resistance against bacterial infections. These natural plant extracts can potentially be used in combination with conventional antibiotics to enhance their effectiveness or as an alternative to antibiotics to reduce the risk of antibiotic resistance. However, it is important to note that more research is needed to fully understand the antimicrobial properties and potential uses of these compounds from natural plant extracts. It is also important to consult with a healthcare professional before using any natural plant extracts as a treatment. They may be incorporated into oral health products, such as mouthwash, toothpaste, biofilms, and tooth powder, as they have been shown to have beneficial effects on oral health [1]. They can reach their goal and purpose in relation to the targeted organs [2; 3; 4]. Lysimachia nummularia L. has a long history of use in traditional folk medicine. In traditional Chinese medicine, it has been used to treat various ailments, such as inflammation, diarrhea, and jaundice. It has also been used to promote diuresis, in detoxification, and to alleviate pain [5]. In European traditional medicine, the plant has been used as an as stringent, diuretic, and expectorant. It has also been used to treat jaundice, kidney stones, and bladder infections. Additionally, it has been used as a topical remedy for skin conditions, such as eczema, psoriasis, and dermatitis [6]. In Native American traditional medicine, _Lysimachia nummularia_ L. was used to treat digestive disorders, respiratory infections, and skin ailments [7]. Lysimachia nummularia L. contains various chemical compounds, including flavonoids, iridoids, triterpenoids, and tannins. Some of the specific compounds found in this plant include hyperoside, a flavonoid with antioxidant properties that has been shown to have anti-inflammatory and neuroprotective effects, rutin, another flavonoid with antioxidant properties that has been found to have anti-inflammatory and antitumor effects [8; 9], nummularoside and ursolic acid, triterpenoids with anti-inflammatory, antitumor, and antiviral activities [10], and tannins, a compound with astingt properties that can be used to treat diarrhea, hemorrhoids, and other gastrointestinal disorders [6]. These compounds are believed to contribute to the medicinal properties of _Lysimachia nummularia_ L., although further research is needed to fully understand their effects and potential use in medicine. Before obtaining the dried extracts, we previously identified, separated, and quantitatively determined the phenolic compounds obtained from _Lysimachia nummularia_ L. (_radix_, _hebra_, and _flores_) and thus we demonstrated its antioxidant properties [11]. The human oro-dental cavity hosts over 700 bacterial species (Gram-positive, Gram-negative) and is defined as one of the most complex microbial flora in the human body; most of these bacterial species are associated with dental plaque and may represent important elements in the etiopathogenesis of periodontitis and dental caries [12]. These diseases were identified in recent reports by the WHO as being the most common infectious human diseases that constantly register an increase in incidence in all countries of the world. Trans-resveratrol is a natural phenolic compound found in various plants, including grapes and peanuts, and has been studied for its potential antibacterial effects against _Enterococcus faecalis_, as well as its ability to induce the production of plant defense compounds, such as phytoalgebras [13]. Some studies suggest that _trans_-resveratrol may have antimicrobial effects against a range of microorganisms, including bacteria, viruses, and fungi, and that it was effective in inhibiting the growth of several _Enterococcus_ species, including _Enterococcus faecalis_ and _Enterococcus ficeium_.