group of naturally occurring, non-steroidal plant compounds that have the ability to cause estrogenic or anti-estrogenic effects. Phytoestrogens are not essential nutrients [1; 2; 3; 4; 5; 6]. There are several phytoestrogen families, including coumestan, lignans, resorcylic acid lactones, and isoflav, presents in many foods, such as fruits and vegetables, tea, and wine, including botanical dietary food supplements [7]. Phytoestrogens can attach to the same estrogen receptors. It is believed that phytoestrogens compete with estradiol for binding to intercellular estrogen receptors. The estrogenic action of phytoestrogens can be either agonistic or antagonistic according not only to their tissue concentrations but also to the endogenous estrogen levels occurring at different human life stages [8]. As a weak estrogen, isoflav can compete with the more potent natural endogenous estrogens to act as an anti-estrogen, which has important implications for reducing breast cancer risk. The hormone action of these agents has been known for some time [9; 10; 11], and estrogenic and/or anti-estrogenic effects have been observed in farm and wild animals, in vivo and in vitro tests, and in humans [3; 12; 13; 14; 15]. In vitro assays have shown the estrogenic agonist activity of certain phytoestrogens at lower concentrations, which stimulate mammary cell proliferation and gene expression of estrogen-dependent genes, whereas at higher concentrations they may antagonize natural hormones [1; 16; 17; 18]. Although evolutionary adaptation to phytoestrogens has occurred, exposure to high concentrations of some phytoestrogens may be associated with a risk [19; 20; 21] of alterations in cellular production, hormone metabolism or action, protein synthesis, and malignant cell multiplication or angiogenesis, as well as other functions [22; 23; 24]. It has been suggested that the high prevalence of hormone-dependent cancers and other disorders in Western populations could be associated with the decline in fruit and vegetable intake over the last 50 years [25; 26]. Emerging evidence suggests that phytoestrogens may have a preventive role in chronic disorders, warranting further investigation into their dietary implications [27], and investigators continue to study the nutritional contribution of these compounds to metabolic functions as diverse as cholesterol regulation and the maintenance of postmenopausal bone density [23; 28]. Certain phytoestrogens have antioxidant properties. This also means that, in addition to the potential health benefits of nutrients, they combat cell damage in the body which is connected to a wide spectrum of chronic disorders, also known as the anti-aging effect [29]. Recent studies have highlighted the importance of various dietary supplements, including boron, in maintaining bone health [30]. The most well-studied group is isoflav, like genistein and daidzein, which appear to be the strongest and are found in a wide range of foods, especially cereals, legumes, vegetables, and fruits, with soybeans being the most plentiful human source [28; 31; 32]. Lignans are phytoestrogens found in nuts, grains, plants, seeds, tea, and wine. Lignans are claimed to have an antioxidant function when they are converted into estrogen-like substances by naturally occurring bacteria in the body [33]. Daidzein, genistein, and equal are powerful free radical scavengers and have high antioxidant activity in vitro [34]. Equol's characteristics decrease skin aging in conjunction with its anti-aging skin effects through the reduction in oxidative stress cascade events by a combination of a variety of biochemical/molecular mechanisms and actions to improve human skin health [35]. Lignans exert antioxidant and anti-inflammatory effects, as well as activity in estrogen receptor-dependent pathways [36]. The neuroprotective properties of phytoestrogens appear to be associated with both their antioxidant effects and their estrogen receptor interaction.