# Gene Networks and Pathways Involved in _Escherichia coli_ Response to Multiple Stressors
## 3 Results
### Functional Categories Involved in E. coli Response to Multiple Stressors
\begin{table}
\begin{tabular}{c c c c c c c c c} \hline \hline \multirow{2}{*}{**Functional Category**} & \multirow{2}{*}{**Function Type**} & \multirow{2}{*}{**Names of Genes**} & \multirow{2}{*}{**Names of Genes**} & \multirow{2}{*}{**Notes**} & \multirow{2}{*}{**Notes**} & \multirow{2}{*}{**Notes**} & \multirow{2}{*}{**Notes**} & \multirow{2}{*}{**Notes**} & \multirow{2}{*}{**Notes**} & \multirow{2}{*}{**Notes**} \\  & & & & & & & & & \\  & & & & & & & & & \\ \hline \multirow{8}{*}{**Transport**} & B lactam resistance & 3 & _oppb_, _oppc_, _ampG_ & \(\times\) & \(\times\) & & & \(\times\) & \(\times\) \\  & Electron & 1 & _rsxC_ & \(\times\) & \(\times\) & & \(\times\) & \(\times\) & \(\times\) \\  & Iron & 2 & _fecC_, _efo_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & Nucleoside & 1 & _tsx_ & \(\times\) & & \(\times\) & \(\times\) & \(\times\) \\  & Fatty acid & 1 & _fallL_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & Sugar & 4 & _gatA_, _frRb_, _ptsG_, _mgIA_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & Amino acid & 10 & _licvM_, _licG_, _llivF_, _artQ_, _artp_, _lysP_, _plaP_, _pheP_, _codB_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & Others & 7 & _xumP_, _urrA_, _vBi_, _diB_, _thiP_, _potB_, _potD_ & \(\times\) & \({}^{\text{a}}\times\) & \(\times\) & \(\times\) & \(\times\) \\ \hline \multirow{8}{*}{**Metabolic pathways**} & Purine biosynthesis & 12 & _purrD_, _purrD_, _purrD_, _purrD_, _purM_, _purN_, _prsP_, _purE_, _purT_, _purK_, _purF_, _purC_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & Antibiotics biosynthesis & 7 & _accC_, _gpu_, _accE_, _id_, _liC_, _sdB_, _dapB_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & Pyrimidine metabolism & 8 & _pyrB_, _pyrD_, _pxP_, _carA_, _upp_, _pyrC_, _coda_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & Argin biosynthesis & 3 & _argD_, _gdhA_, _alaA_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & Glycine, serine and threonine metabolism & 6 & _thrA_, _thrB_, _gcVT_, _gxCvP_, _lysC_, _glyA_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & Cysteine methionine & 3 & _ynjE_, _metE_, _metC_ & \(\times\) & & \(\times\) & \(\times\) & \(\times\) \\  & metabolism & 2 & _trpE_, _cysJ_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & Amino acid biosynthesis & 2 & _trpE_, _cysJ_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & Lipopolysaccharide & 4 & _eptC_, _wauL_, _waaC_, _lpxH_ & \(\times\) & & & \(\times\) & \(\times\) \\  & biosynthesis & 2 & _pfo_, _aldA_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & Pyruvate metabolism & 2 & _pfo_, _aldA_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & Transferase & 4 & _hsdM_, _grB_, _lipB_, _opgH_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & Hydrolase & 8 & _mgtA_, _frmB_, _ydC_, _hypB_, _yHbC_, _yIIE_, _ruA_, _rnb_ & & & & \\  & & _atpP_, _niU_, _niU_, _nucA_, _rnU_, _guB_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & Oxidative phosphorylation & 8 & _unoE_, _niU_, _niU_, _quB_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & Others & 6 & _speA_, _bioD_, _pntA_, _gatD_, _ycaO_, _hypD_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\ \hline \multirow{2}{*}{**Cellular Response**} & Stimulus & 2 & _tsgA_, _borD_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & Acidic pH & 3 & _evgS_, _ygQ_, _yggB_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\ \hline \multirow{2}{*}{**Motility**} & Flagellum biogenesis and & 3 & _flipP_, _fhA_, _flB_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\  & protein export & Flagellar assembly & 4 & _fliM_, _flgH_, _flgG_, _fliK_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\ \hline \multirow{2}{*}{**Peptidoglycan**} & Biosynthetic process & 4 & _dacA_, _mipA_, _lpoA_, _murI_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\ \hline \multirow{2}{*}{**Transcription**} & Regulation & 3 & _fs_, _mprA_, _sublB_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\ \hline \multirow{2}{*}{**Others**} & & 3 & _cvpA_, _grS_, _yeiD_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\ \hline \multirow{2}{*}{**Uncharacterized**} & Proteins & 3 & _ymfl_, _ydilj_, _yedE_ & \(\times\) & \(\times\) & \(\times\) & \(\times\) & \(\times\) \\ \hline \hline \end{tabular}  
* An \(\times\) denotes that half or more of the genes within a functional category are differentially expressed. \({}^{\text{a}}\times\) For oxidative 3 out of 7 genes are upregulated.  
\end{table}