## 2 Materials and Methods
### Chemistry
13C NMR (DMSO-d6, 100 MHz) \(\delta\): 21.63 (C1-CH3), 122.58 (C2\({}^{\prime}\), C6\({}^{\prime}\)), 128.70 (C4\({}^{\prime}\)), 129.19 (C2\({}^{\prime\prime}\), C6\({}^{\prime\prime}\)), 129.37 (C3, C5), 130.13 (C3\({}^{\prime\prime}\), C5\({}^{\prime\prime}\)), 130.76 (C2, C6), 131.66 (C4), 132.79 (C3\({}^{\prime}\), C5\({}^{\prime}\)), 133.58 (C4\({}^{\prime\prime}\)), 135.05 (C1\({}^{\prime\prime}\)), 147.19 (N=CH), 146.46 (C1), 151.68 (C1\({}^{\prime}\)), 162.48 (C=O). MS (ESI) \(m/z\) calcd. for C21H17 ClN2O4S [M+2H]+ 430.06, found 429.91. _N\({}^{\prime}\)-[(2-Fluorophenyl)methylidene)]-4-[(4-methylphenyl)sulfonyl]benzoylhydrazizide_ (**3**n). Yield 93.0%. mp 146.5-147.0 \({}^{\circ}\)C. HPLC tR: 7.470 min, purity: 99.77%. 1H NMR (DMSO-d6, 400 MHz) \(\delta\): 2.42 (s, 3H, C1-CH3),123.47 (C6\({}^{\prime\prime}\)), 128.24 (C4\({}^{\prime}\)), 129.71 (C3, C5), 130.31 (C2, C6), 130.97, 130.87 (C5\({}^{\prime\prime}\)), 131.20 (C4), 132.28 (C3\({}^{\prime}\), C5\({}^{\prime}\)), 136.72, 136.79 (C1\({}^{\prime\prime}\)), 146.03 (C1), 146.69 (N=CH), 151.27 (C1\({}^{\prime}\)), 161.17, 162.12 (C3\({}^{\prime\prime}\)), 163.60 (C=O). MS (ESI) \(m/z\) calcd. for C21H17 FN2O4S [M]+ 412.09, found 412.07. _N\({}^{\prime}\)-[(4-Fluorophenyl)methylidene)]-4-[(4-methylphenyl)sulfonyl]benzoylhydrazazide_ (**3p**). Yield 98.8%. mp 174.8-175.5 \({}^{\circ}\)C. HPLC tR: 6.625 min, purity: 99.07%. 1H NMR (DMSO-d6, 400 MHz) \(\delta\): 2.40 (s, 3H, C1-CH3), 7.18-7.21 (d, 2H, J = 8.8 Hz, H2\({}^{\prime}\), H6\({}^{\prime}\)), 7.26-7.30 (d, 2H, J = 9.2, 8.4 Hz, H3\({}^{\prime\prime}\), H5\({}^{\prime\prime}\)), 7.46-7.48 (d, 2H, J = 8.4 Hz, H2, H6), 7.76-7.80 (d, 4H, J = 8.4, 7.6 Hz, H3, H5\({}^{\prime}\), H2\({}^{\prime\prime}\), H6\({}^{\prime\prime}\)), 7.90-7.92 (d, 2H, J = 8.4 Hz, H3\({}^{\prime}\), H5\({}^{\prime}\)), 8.41 (s, 1H, N=CH), 11.92 (s, 1H, CONH). 13C NMR (DMSO-d6, 100 MHz): \(\delta\) 21.19 (C1-CH3), 115.81, 116.03 (C3\({}^{\prime\prime}\), C5\({}^{\prime\prime}\)), 122.68 (C2\({}^{\prime}\), C6\({}^{\prime}\)), 128.28 (C4\({}^{\prime}\)), 129.29, 129.38 (C2\({}^{\prime\prime}\), C6\({}^{\prime\prime}\)), 129.69 (C3, C5), 130.33 (C2, C6), 130.80, 130.83 (C1\({}^{\prime\prime}\)), 131.22 (C4), 132.44 (C3\({}^{\prime}\), C5\({}^{\prime}\)), 146.05 (C1), 146.99 (N=CH), 151.24 (C1\({}^{\prime}\)), 161.96, 162.05 (C4\({}^{\prime\prime}\)), 164.42 (C=O). MS (ESI) \(m/z\) calcd. for C21H17 FN2O4S [M]+ 412.09, found 411.99. _N\({}^{\prime}\)-[(2-Nitrophenyl)methylidene)]-4-[(4-methylphenyl)sulfonyl]benzylhydrazazide_ (**3r**). Yield 96.3%. mp 180.0-180.4 \({}^{\circ}\)C. HPLC tR: 6.586 min, purity: 99.39%. 1H NMR (DMSO-d6, 400 MHz) \(\delta\): 2.41 (s, 3H, C1-CH3), 7.19-7.22 (d, 2H, J = 8.8 Hz, H2\({}^{\prime}\), H6\({}^{\prime}\)), 7.47-7.49 (d, 2H, J = 8.0 Hz, H2, H6), 7.65-7.68 (t, 1H, J = 7.6 Hz, H4\({}^{\prime\prime}\)), 7.76-7.78 (d, 2H, J = 8.0 Hz, H3, H5), 7.78-7.81 (t, 1H, J = 7.6 Hz, H5\({}^{\prime\prime}\)), 7.93-7.95 (d, 2H, J = 7.6 Hz, H3\({}^{\prime}\), H5\({}^{\prime}\)), 8.05-8.07 (d, 1H, J = 8.0 Hz, H3\({}^{\prime\prime}\)), 8.11-8.12 (d, 1H, J = 7.2 Hz, H6\({}^{\prime\prime}\)), 8.54 (s, 1H, N=CH), 12.19 (s, 1H, CONH). 13C NMR (DMSO-d6, 100 MHz) \(\delta\): 21.15 (C1-CH3), 122.14 (C2\({}^{\prime}\), C6\({}^{\prime}\)), 124.65 (C3\({}^{\prime\prime}\)), 127.93 (C1\({}^{\prime\prime}\)), 128.23 (C4\({}^{\prime}\)), 128.60 (C6\({}^{\prime\prime}\)), 129.79 (C3, C5), 130.29 (C2, C6), 130.71 (C4\({}^{\prime\prime}\)), 131.19 (C4\({}^{\prime}\)), 132.00 (C3\({}^{\prime}\), C5\({}^{\prime}\)), 133.69 (C5\({}^{\prime\prime}\)), 143.33 (C2\({}^{\prime\prime}\)), 146.01 (C1), 148.20 (N=CH), 151.37 (C1\({}^{\prime}\)), 162.19 (C=O). MS (ESI) \(m/z\) calcd. for C21H17N3O6S [M]+ 439.08, found 439.03. _N\({}^{\prime}\)-[(3-Nitrophenyl)methylidene)]-4-[(4-methylphenyl)sulfonyl]benzoylhydrazazide_ (**3s**). Yield 97.7%. mp 182.5-183.1 \({}^{\circ}\)C. HPLC tR: 6.820 min, purity: 99.04%.