## 1 Introduction  
Natural products are widespread used for nourishment and therapeutic goals [1]. However, the mechanisms of their actions and their efficacy, in general, are not fully studied. [2]. Paullinia cupana_ (guarana) is a Brazilian plant (subfamily Sapindoideae) known for its stimulant and medicinal properties [3, 4]. Guarana has been associated with diverse pharmacological properties, such as antiproliferative [5], anti-inflammatory [6], antioxidant, and cardioprotective [4, 7, 8]. Moreover, it would have cytoprotective [4], energetic, thermogenic [9], antidepressant [10], and anxiolytic [11] qualities (Figure 1). This natural product is commonly consumed by dissolving the powder of its seeds in water or in association with other herbal drugs. Currently, guarana is exploited on a large scale by food supplements and the soft drinks industry for its effects on physical performance and body mass control [4]. The effects of some substances [12, 13], including natural products [14, 15], in association with whole-body vibration (WBV) exercise have been reported. WBV is a type of exercise based on body adaptations to exposure to mechanical vibrations (MV) generated in a vibrating platform (VP) [16]. [PERSON] et al. [17] discussed various parameters associated with WBV exercises and, consequently, the frequency and peak-to-peak displacement, which are biomechanical parameters, must be selected and adapted to each person. Exposure time interspersed with a rest time must be also considered [17, 18]. In controlled conditions, MV have generated WBV exercises in feasible, useful, and safe conditions [18]. In addition, WBV exercises have been considered as a noninvasive and non-pharmacological intervention [19]. The effects of WBV exercises on plasma concentrations of selected biomarkers have been studied in human beings [20, 21, 22]. In addition, some investigations have reported that WBV exercises could improve muscle activity, force and power [23, 24], balance and flexibility [25], and cognitive performance [26]. Studies about the use of WBV exercises have increased over time [[[https://www.ncbi.nlm.nih.gov/pubmed/?term=whole+body+vibration](https://www.ncbi.nlm.nih.gov/pubmed/?term=whole+body+vibration)]([https://www.ncbi.nlm.nih.gov/pubmed/?term=whole+body+vibration](https://www.ncbi.nlm.nih.gov/pubmed/?term=whole+body+vibration))], and therefore the development of experimental models to assess the effects of this type of exercise in tissues and organs is desirable. In experimental designs, the course of a drug (synthetic and natural) treatment or even WBV intervention can be evaluated with the effect on the radiopharmaceutical distribution [27, 28]. Sodium peretechnate (Na\({}^{99m}\)TcO\({}_{4}\)) is an example of a radiopharmaceutical used in clinical [29, 30] and experimental approaches [28, 31, 32]. Furthermore, parameters, such as food intake, body mass, and stool consistency could also support understanding the effects of the current intervention,  
Figure 1: Biological effects of _Paullinia cupana_. as they have been verified with some medicinal plants, and _Coriandrum sativum_[15] and _Chenopodium ambrosioides_[33]. In view of the various actions of guarana extract in _in vitro_[2; 5; 6] and _in vivo_ studies [10; 11; 34], or even in preparations associated with other herbal drugs (chemical agents) [7], very little is known about the biological effects of guarana in association with a physical agent. These considerations were the motivation for the current investigation. Therefore, this work aimed to investigate the biological effects of guarana in Wistar rats in combination with WBV exercises (50 Hz, peak acceleration of 7.84 x g) on physiological parameters such as the biodistribution of Na\({}^{99\text{m}}\)TcO\({}_{4}\), blood biochemical analysis, food intake, body mass, and stool consistency.