# 2\({}^{\prime}\)-Hydroxylfavanone: A Bioactive Compound That Protects against Cancers
## 2 Role of 2\({}^{\prime}\)-Hydroxyflavanone in Various Cancers
### Pancreatic Cancer
In murine macrophages, 2 HF blocks LPS-induced loss of mitochondrial membrane potential, nitric oxide (NO) production, reactive oxygen species (ROS), and lipid peroxidation. Induction of the protein kinases SAPK/JNK and p38 MAPK is forbidden by 2 HF. LPS-induced phosphorylation, DNA binding of the redox transcription factor NF-kB, and nuclear translocation are also averted by 2 HF. LPS-induced liberation of inflammatory chemokines and cytokines such as eotaxin, IL-12p40, IL-15, IL-2, MCP-1, LIX, IL-10, IL-17, and TNF-\(\alpha\) is restricted by 2 HF [53]. Docking studies were conducted between 11 hydroxyflavanones with hydroxy groups at various positions, one flavonone, and _Enterococcus faecalis_ KAS III (efKAS III) disclosed the binding potential to efKAS III and the MIC values of these flavonones for E. faecalis and vancomycin-resistant E. faecalis (VEGF). efKAS III docks well with naringenin, eriodictyl, and taxifolin due to their great binding affinities and high-scoring function. The major interactions for efKAS III inhibition are seen to be the side chain of Arg38, the 5\({}^{\prime}\)- and 4\({}^{\prime}\)-hydroxy group's hydrogen bonds among each other, and the backbone carbonyl of Phe308. Therefore, flavonones can be potential antimicrobials [54]. Generation of formyl-l-methionyl-l-leucyl-l-phenylalanine (fMLP)-induced superoxide anion by human neutrophils is inhibited by 2S-7\({}^{\prime}\)-hydroxyflavanone [55]. The number of viable _Streptococcus pneumoniae_ in the lung decreased upon administration of 7\({}^{\prime}\)-hydroxyflavanone (1 mg/mouse) and _Zucagnia punctata_ extract (ZpE) (1 mg/mouse). The intake of Flavonoid 7 HF extracted from _Zuccagnia punctata_ or _Zuccagnia punctata_ extract once or twice a day could be a potential treatment for respiratory infections [56]. An increase in the levels of P-glycoprotein (P-gp) expression was observed in HK-2 cells in the presence of ZpE or dihydroxyflavone (DHF) for 72 hrs, whereas the activity of HK-2 cells either dropped or remained unchanged. No effect of 7 HF was observed in HK-2 cells [57]. Apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in HeLa cancer cells was amplified by 6-hydroxyflavanone (6-HF) and its derivative 6-propionoxy-flavonone (6-PF). A decrease in the mitochondrial membrane potential and an increase in the expression of the TRAIL-R2 death receptor led to the apoptosis of HeLa cells. Therefore, flavonones can be of potential use in TRAIL-based anticancer therapy, as they magnify the anticancer effects of TRAIL [58]. Collagen synthesis in human dermal fibroblasts by flavonone, flavone, and flavonoid illustrate varying effects. There was a decline in the collagen concentration due to quercetin-3, 3\({}^{\prime}\), 4\({}^{\prime}\), 7-tetramethyl ether, flavonone, fiesetin, and 4\({}^{\prime}\)-hydroxyflavanone. The levels of collagen increased with morin, rutin, and chrysin, with no change in the overall protein concentration. Naringenin displays no effect on total protein concentration or total collagen, whereas protein concentration drops due to the cytotoxicity of 5, 7-pentahydroflavone, quercetin-3,3,4\({}^{\prime}\), 3-methyl quercetin, and 7-hydroxy flavone [59]. A comparison of the immunomodulatory activity of certain flavonoids between levamisole and cell-mediated immune responses and antigen-specific humoral and complement-mediated hemolysis demonstrated that the primary response in mice was inhibited by rutin, 6-hydroxyflavanone, and 7-hydroxyflavanone, while bavachinin amplified sheep erythrocyte (SRBC), 7\({}^{\prime}\)-methoxyflavanone, flavonone, and 6-methoxyflavonone-initiated both humoral immune responses-primary and secondary. There was the suppression of the secondary response and stimulation of the primary response in levamisole. No effect was seen on classical or alternative pathway-dependent hemolysis by any of the flavonoids. There was a decrease in the exhibition of SRBC-induced delayed-type hypersensitivity reactions by all the flavonoids.