## 1 Introduction  
Epigenetics refers to the reversible and heritable changes in gene function when there is no change in the nuclear DNA sequence [1]. DNA methylation modifications play important roles in epigenetic regulation of gene expression without altering the sequence, and it is widely distributed in the genome of different species [2]. It can be divided into three categories according to the position of methylation modification: N6-methyladenine (6 mA), 5-Methylcytosine (5 mC), and N4-methylcytosine (4 mC) [3, 4]. DNA methylations at the 5 th position of the pyrimidine ring of cytosine 5-Methylcytosine(5 mC) and at the 6 th position of the purine ring of adenine N6-methyladenine (6 mA) are the most common DNA modifications in eukaryotes and prokaryotes, respectively [5]. Previous studies have shown that DNA N6-methyladenine (6 mA) is associated with germ cell differentiation, stress response, embryonic development, nervous system, and other processes [6, 7, 8, 9]. N6-Methyladenine (6 mA) DNA methylation has recently been implicated as a potential new epigenetic marker in eukaryotes, including the _Arabidopsis thaliana_, _Rice_, _Drosophila melanogaster_, and so on [5; 8; 10]. [PERSON] et al. reveal that 6 mA is a conserved DNA modification that is positively associated with gene expression and contributes to key agronomic traits in plants [11]. Some studies have found that N6-methyladenine DNA modification is also widely distributed in the Human Genome and plays important biological functions. [PERSON] et al. demonstrate that 6 mA DNA modification is extensively present in human cells, and the decrease of genomic DNA 6 mA promotes human tumorigenesis [12]. [PERSON] et al. proposed a 6 mA DNA modification area as a new mechanism for the epigenetic regulation of stem cell differentiation [13]. [PERSON] et al. report that N6-methyladenine DNA modifications are enriched in human glioblastoma, and targeting regulators of this modification can inhibit cancer growth by altering heterochromatin landscapes and downregulating oncogenic programs [14]. Therefore, how to quickly and accurately detect the DNA 6 mA modification sites is also an important research topic in these epigenetic studies. Due to the rapid development of high-throughput sequence technology, various experimental techniques have been proposed to detect DNA 6 mA modifications and study protein function. [PERSON] et al. developed a protocol using bisulfite sequencing and a methyl-DNA immunoprecipitation technique to analyze genome-wide DNA methylation in eukaryotes [15]. [PERSON] et al. reported a fast and sensitive method for the quantification of global adenine methylation in DNA, using laser-induced fluorescence and capillary electrophoresis [16]. [PERSON] et al. proposed the single-molecule real-time sequencing (SMRT) technology to detect the 4 mC and 6 mA sites from the whole genome [17]. [PERSON] et al. used ultra-high performance liquid chromatography coupled with mass spectrometry technique to access DNA 6 mA levels in _Caenorhabditis elegans_[18]. By performing mass spectrometry analysis and 6 mA immunoprecipitation followed by sequencing (IP-seq), [PERSON] and his colleagues obtained the 6 mA profile of the rice genome [10]. Although experimental methods indeed yielded encouraging results, the technology cannot detect m6A sites from the whole genome and the cost of the technique is high. Therefore, it is necessary to develop a computational model that can efficiently and accurately predict and identify 6 mA sites. Recent studies focus more on the recognition of 6 mA sites using machine learning [19], which is capable of predicting 6 mA sites based on genome sequences, without any prior experimental knowledge. [PERSON] et al. developed the first ML-based method named i6 mA-Pred for identifying DNA 6 mA sites and provided a benchmark 6 mA dataset containing 880 6 mA sites and 880 non-6 mA sites in the rice genome.