###### Abstract  
To thrive, an organization must adapt to the fast and constant change in the economic environment caused by an aging society, technological changes, and the pandemic crisis. Innovation becomes important for the adaptation of industries. Healthcare is one of them. Innovation development in hospitals is effective and acceptable when its management is effective and aligns with the healthcare quality context since quality is a philosophy of work in life-related settings. To the best of our knowledge, quality management and innovation management in healthcare have never been integrated. Therefore, this research aimed to create an integrated framework of quality and innovation management in healthcare (TQIM-H). To establish the effectiveness of applying TQIM-H for the development of effective healthcare innovation, this study developed a TQIM-H conceptual framework using multiple methodologies including a literature review, multiple case studies analysis, Delphi study with healthcare experts, Technology Acceptance Model (TAM), and triangulation with an external dataset. We constructed a TQIM-H conceptual framework, consisting of seven dimensions, that can be used in developing innovation projects in hospitals and which agrees with safety and quality principles in hospitals.  
quality and innovation management; healthcare management; healthcare innovation; effective innovation development 202257  
and quality [26; 27]. On the other hand, some researchers proposed that quality supports the innovation development process. High-quality innovation impresses customers and increases working quality and efficiency [28; 29].  
For the healthcare industry, [PERSON] and [PERSON] (2020) [30] found that quality management has a positive relationship with innovation management in the healthcare industry since innovation maximizes the capability of quality management and clarifies the goal of quality management. At the same time, quality guides the direction of innovation development to be safe, ethical, legal and acceptable. While the two management frameworks have a common goal to serve customer needs, [PERSON] and [PERSON] (2020) only explained the relationship between quality management in healthcare and innovation management in healthcare. The study did not develop the integrated conceptual framework of quality management healthcare and innovation management in healthcare and did not provide the details of the integrated conceptual framework. Therefore, this study aimed to integrate quality management and innovation management so the integrated framework can be used to develop healthcare innovation projects and allow the development to be efficient and agree with the quality background.  
To develop the integration framework of healthcare quality and innovation management, we used four methodologies. First, a literature review was used to integrate two management philosophies' factors, resulting in the integrated factors. Second, several case studies were examined to confirm the integrated factors. Third, a Delphi study was carried out to develop the conceptual framework. Forth, The Technology Acceptance Model (TAM) was used to assess the acceptability of the developed framework. The conceptual framework was then tested and validated by using the framework to develop an innovation project in a case study hospital from start to finish. The developed integration framework will be used as a structural management framework whose key dimensions and subfactor components can be used as a guideline for the development of healthcare innovation projects while still allowing hospitals to adhere to the quality principle.