## 2 Materials and Methods
### Chemistry
IR \(v_{\max}\) (KBr): 3319, 3205, 2954, 2929, 1643, 1553, 1524, 1449, 1384, 1354, 1273, 1249, 1170, 1158, 1080, 1032, 977 cm\({}^{-1}\), 1H-NMR (600 MHz, DMSO) 8: 891 (1H, d, \(J\) = 9.6 Hz, ArH), 8.81 (1H, br s, NH, exchange with D\({}_{2}\)O), 8.69 (1H, br s, NH, exchange with D\({}_{2}\)O), 8.16 (1H, d, \(J\) = 1.8 Hz, ArH), 7.96-7.92 (2H, m, ArH), 7.83 (1H, \(J\) = 9.6 Hz, ArH), 7.65 (1H, d, \(J\) = 8.4 Hz, ArH), 7.55 (1H, d, \(J\) = 9.6 Hz, ArH), 7.52 (1H, t, \(J\) = 7.8 Hz, ArH), 6.10 (1H, s, C=CH), 5.86 (1H, s, C=CH), 4.23 (4H, t, \(J\) = 7.5 Hz, NCH\({}_{2}\)(CH\({}_{2}\))\({}_{4}\)CH\({}_{3}\)), 1.76-1.67 (4H, m, NCH\({}_{2}\)CH\({}_{2}\)(CH\({}_{2}\))\({}_{3}\)CH\({}_{3}\)), 1.51 (2H, qt, N(CH\({}_{2}\))\({}_{2}\)CH\({}_{2}\)({}_{2}\)(CH\({}_{2}\))\({}_{2}\)CH\({}_{3}\)), 1.42 (2H, qt, N(CH\({}_{2}\))\({}_{2}\)CH\({}_{2}\)({}_{2}\)(CH\({}_{3}\))\({}_{3}\)), 1.36-1.2 Vis \(\lambda_{\rm max}\) (ACT): 703 nm, log \(\varepsilon\) = 5.21. Vis \(\lambda_{\rm max}\) (DCM): 707 nm, log \(\varepsilon\) = 5.30. Vis \(\lambda_{\rm max}\) (DMF): 711 nm, log \(\varepsilon\) = 5.20. Vis \(\lambda_{\rm max}\) (DXN): 716 nm, log \(\varepsilon\) = 5.15. Vis \(\lambda_{\rm max}\) (EtOH): 702 nm, log \(\varepsilon\) = 5.28. Vis \(\lambda_{\rm max}\) (MeOH): 698 nm, log \(\varepsilon\) = 5.25. Vis \(\lambda_{\rm max}\) (THF): 714 nm, log \(\varepsilon\) = 5.17. IR \(\upsilon_{\rm max}\) (KBr): 3240, 2953, 2930, 1623, 1551, 1445, 1380, 1347, 1286, 1242, 1180, 1157, 1112, 1078, 1029, 988 cm\({}^{-1}\); \({}^{1}\)H-NMR (400 MHz, DMSO) \(\delta\): 9.02 (2H, br s, NH, exchange with D\({}_{2}\)O), 9.00 (1H, d, \(J\) = 9.6 Hz, ArH), 8.88 (1H, d, \(J\) = 9.6 Hz, ArH), 8.21 (1H, s, ArH), 8.13 (1H, s, ArH), 8.00-7.96 (2H, m, ArH), 7.93-7.90 (3H, m, ArH), 7.78 (1H, d, \(J\) = 9.6 Hz, ArH), 7.71 (1H, d, \(J\) = 8.8 Hz, ArH), 7.64 (2H, t, \(J\) = 8.4 Hz, ArH), 7.59 (1H, d, \(J\) = 6.0 Hz, ArH), 7.55 (1H, d, \(J\) = 7.2 Hz, ArH), 7.52-7.48 (2H, m, ArH), 7.38 (1H, t, \(J\) = 8.8 Hz, ArH), 6.19 (1H, s, C=CH), 6.04 (1H, s, C=CH), 5.92 (1H, s, C=CH), 5.82 (1H, s, C=CH), 4.35 (4H, br t, \(J\) = 7.0 Hz, NCH\({}_{2}\)(CH\({}_{2}\))\({}_{4}\)CH\({}_{3}\)), 4.26 (4H, br t, \(J\) = 7.0 Hz, NCH\({}_{2}\)(CH\({}_{2}\))\({}_{4}\)CH\({}_{3}\)), 3.35 (3H, s, NCH\({}_{3}\), only appears in DMSO + D\({}_{2}\)O spectrum), 3.32 (3H, s, NCH\({}_{3}\), only appears in DMSO + D\({}_{2}\)O spectrum), 1.72 (8H, br qt, NCH\({}_{2}\)CH\({}_{2}\)(CH\({}_{2}\))\({}_{3}\)CH\({}_{3}\)), 1.49 (4H, br qt, N(CH\({}_{2}\))\({}_{2}\)CH\({}_{2}\)(CH\({}_{2}\))\({}_{2}\)CH\({}_{3}\)), 1.40 (4H, br qt, N(CH\({}_{2}\))\({}_{2}\)CH\({}_{2}\)(CH\({}_{2}\))\({}_{2}\)CH\({}_{3}\)), 1.36-1.27 (16H, m, N(CH\({}_{2}\))\({}_{3}\)(CH\({}_{2}\))\({}_{2}\)CH\({}_{3}\)), 0.90-0.84 (12H, m, N(CH\({}_{2}\))\({}_{5}\)CH\({}_{3}\)) ppm; \({}^{13}\)C-NMR (100.63 MHz, DMSO) 8: 173.62, 173.54,165.36, 165.30, 160.88, 159.21, 157.22, 156.59, 155.70, 154.51, 150.55, 149.52, 140.59, 140.47, 140.21 (ArCH), 139.87 (ArCH), 138.46, 138.13, 136.88 (ArCH), 136.56 (ArCH), 134.16 (ArCH), 132.83 (ArCH), 127.84 (ArCH), 127.62 (ArCH), 126.78, 126.35, 125.25 (ArCH), 125.10 (ArCH), 124.99 (ArCH), 124.48 (ArCH), 122.76 (ArCH), 122.47 (ArCH), 121.74, 119.60, 118.09 (ArCH), 117.77 (ArCH), 113.35 (ArCH), 112.94 (ArCH), 94.03 (C=CH), 93.65 (C=CH), 90.11, 89.25, 86.61 (C=CH), 86.33 (C=CH), 48.18 (NCH\({}_{2}\)), 48.00 (NCH\({}_{2}\)), 46.41 (NCH\({}_{2}\)), 45.70 (NCH\({}_{2}\)), 31.10 (CH\({}_{2}\)), 30.98 (CH\({}_{2}\)), 30.93 (CH\({}_{2}\)), 30.81 (CH\({}_{2}\)), 30.30 (NCH\({}_{3}\)), 30.06 (NHCH\({}_{3}\)), 27.24 (CH\({}_{2}\)), 26.87 (CH\({}_{2}\)), 26.79 (CH\({}_{2}\)), 26.30 (CH\({}_{2}\)), 25.76 (CH\({}_{2}\)), 25.69 (CH\({}_{2}\)), 25.63 (CH\({}_{2}\)), 22.23 (CH\({}_{2}\)), 22.17 (CH\({}_{2}\)), 22.11 (CH\({}_{2}\)), 22.04 (CH\({}_{2}\)), 13.93 (CH\({}_{3}\)), 13.88 (CH\({}_{3}\)), 13.85 (CH\({}_{3}\)) ppm; HRESI-TOFMS _m/z_: 678.19974 [M-CF\({}_{3}\)SO\({}_{3}\)]\({}^{+}\) (C\({}_{35}\)H\({}_{41}\)IN\({}_{3}\)OS\({}^{+}\), calc. 678.20095).