# Herbal Support for the Nervous System: The Impact of Adaptogens in Humans and Dogs
## 5 Maral Root (_Leuzea carthamoides_ (Wild.) [PERSON])
### Studies Related to Therapeutic Effects on Humans  
_Leuzea carthamoides_ is classified as an adaptogen, meaning it helps the body adapt to stress and restore homeostasis. Its compounds, such as ecdysteoroids, enhance physical endurance, improve recovery, and support the immune system. Additionally, _L. carthamoides_ extracts exhibit antibacterial activity against various Gram-positive and Gram-negative bacterial strains [106; 107; 108]. Due to its properties, _Leuzea carthamoides_ has been used in traditional medicine and as an ingredient in dietary supplements supporting physical performance, immunity, and overall well-being. Studies indicate the pharmaceutical potential of compounds isolated from this plant, opening possibilities for their future applications as natural therapeutic agents [109]. Extracts from _L. carthamoides_ roots stimulate the body after physical exertion and enhance resistance to long-term stress, making them a valuable addition to a dog's diet.  
[PERSON] et al. [110] reported that compounds in _L. carthamoides_, such as \(N\)-feruloyserotonin, can inhibit oxidative bursts in human whole blood and isolated neutrophils, suggesting potential in reducing oxidative stress\(-\)a key factor in the pathogenesis of many neurodegenerative diseases.  
Figure 5: Characteristics of the plant and its principal active compounds [102; 103; 104; 105] (search without time range in the Scopus database with Article title, Abstract, Keywords, searching documents with the following command: (adaptogen name) AND nervous AND human/dog, as of 30 March 2025 [60]).  
The ecdysteroids in _Leuzea carthamoides_ have anti-inflammatory effects, which may help protect neurons from inflammatory processes often associated with neurodegenerative diseases. Furthermore, the presence of compounds such as 20-hydroxycedysone may contribute to protecting nerve cells from damage, which is relevant in the context of neurodegenerative disease prevention [111].  
Compounds contained in _L. carthamoides_ can stimulate neurogenesis, the process of creating new neurons, which is crucial for brain plasticity and cognitive functions. Studies on animal models suggest that extracts from _L. carthamoides_ can improve cognitive functions, such as memory and learning, which may be related to the modulation of neurotransmitters and protection against oxidative stress [107]. The adaptogenic properties of _L. carthamoides_ can improve mood and reduce symptoms of depression, which is important for overall mental health. Therefore, _L. carthamoides_ can affect the regulation of the HPA axis, which is important in the context of stress response and maintaining the body's homeostasis [107].  
Studies on rats have shown that extracts of _L. carthamoides_ in a dosage of 0.2 mL per animal can stimulate protein and RNA biosynthesis in various organs, which may translate into improved cognitive functions [112]. Recommended doses of maral root extract range from 200 to 500 mg per day, divided into two or three servings, depending on individual needs and manufacturer recommendations. There is not enough scientific data to determine the appropriate dose of maral root [104].