## 2 Materials and Methods
### Synthesis
\({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\): 2.68-2.87 (m, 2H, CH\({}_{2}\)CO), 3.63, 3.76. 3.77 (3s, 9H, 3 OCH\({}_{3}\)), 3.95-4.17 (m, 3H, NCH\({}_{2}\), CH), 6.99 (s, 2H, H\({}_{\rm Ar}\)), 7.42-7.78 (m, 4H, H\({}_{\rm Ar}\)), 8.03 (s, 0.65H, CH=N), 8.22 (s, 0.35H, CH=N), 11.65 (s, 0.65H, CONH), 11.71 (s, 0.35H, CONH) ppm. \({}^{13}\)C NMR (101 MHz, DMSO-\(d_{6}\)) \(\delta\): 32.67, 34.75, 35.20, 35.72, 50.41, 51.96, 55.91, 60.11, 97.84, 98.06, 128.56, 128.73, 128.94, 133.09, 134.23, 134.28, 134.35, 134.59, 135.21, 135.26, 142.43, 145.76, 152.67, 168.74, 171.76, 171.89, 173.67 ppm. IR (KBr): \(\
u_{\rm max}\): 3129, (NH), 1681, 1651 (2C=O), 1292, 1279, 1232 (3 OCH\({}_{3}\)) cm\({}^{-1}\). Anal. Calcd. for C\({}_{21}\)H\({}_{22}\)ClN\({}_{3}\)O\({}_{5}\), %: C 58.40; H 5.13; N 9.73. Found: C 58.29; H 5.05; N 9.64. \(N^{\prime}\)-(4-bromobenzylidene)-5-oxo-1(3,4,5-trimethoxyphenyl)pyrrolidine-3-carbohydrazide (**11**) White solid, yield 0.7 g (91%), m. p. 210-211 \({}^{\circ}\)C (from propan-2-ol). \({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\): 2.69-2.89 (m, 2H, CH2 CO), 3.63, 3.76. 3.77 (3s, 9H, 3 OCH\({}_{3}\)), 3.92-4.18 (m, 3H, NCH\({}_{2}\), CH), 6.99 (s, 2H, H\({}_{\rm Ar}\)), 7.52-7.73 (m, 4H, H\({}_{\rm Ar}\)), 8.01 (s, 0.64H, CH=N), 8.20 (s, 0.36H, CH=N), 11.65 (s, 0.64H, CONH), 11.71 (s, 0.36H, CONH) ppm. \({}^{13}\)C NMR (101 MHz, DMSO-\(d_{6}\)) \(\delta\): 32.67, 34.74, 35.19, 35.71, 50.40, 50.95, 55.91, 60.11, 97.84, 98.06, 123.12, 123.38, 128.79, 128.96, 131.82, 131.85, 133.42, 134.22, 134.27, 135.21, 135.25, 142.53, 145.84, 152.67, 168.75, 171.75, 171.88, 173.67 ppm. IR (KBr): \(\
u_{\rm max}\): 3145, (NH), 1689, 1667 (2C=O), 1275, 1221 (3 OCH\({}_{3}\)) cm\({}^{-1}\). Anal. Calcd. for C\({}_{21}\)H\({}_{22}\)BrN\({}_{3}\)O\({}_{5}\), %: C 52.95; H 4.66; N 8.82. Found: C 52.84; H 4.54; N 8.75. \(N^{\prime}\)-(4-fluorobenzylidene)-5-oxo-1(3,4,5-trimethoxyphenyl)pyrrolidine-3-carbohydrazide (**12**) White solid, yield 0.58 g (87%), m. p. 177-179 \({}^{\circ}\)C (from propan-2-ol). \({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\): 2.71-2.89 (m, 2H, CH\({}_{2}\)CO), 3.63, 3.76. 3.77 (3s, 9H, 3 OCH\({}_{3}\)), 3.91-4.24 (m, 3H, NCH\({}_{2}\), CH), 6.99 (s, 2H, H\({}_{\rm Ar}\)), 7.17-8.5 (m, 4H, H\({}_{\rm Ar}\)), 8.03 (s, 0.65H, CH=N), 8.23 (s, 0.35H, CH=N), 11.60 (s, 0.65H, CONH), 11.65 (s, 0.35H, CONH) ppm. \({}^{13}\)C NMR (101 MHz, DMSO-\(d_{6}\)) \(\delta\): 32.67, 34.74, 35.20, 35.73, 50.43, 50.99, 55.91, 60.11, 97.85, 98.07, 115.77, 115.99, 129.05, 129.13, 129.24, 129.32, 130.75, 134.28, 135.27, 142.56, 145.96, 152.67, 161.78, 164.24, 168.66, 171.77, 171.91, 173.60 ppm. IR (KBr): \(\
u_{\rm max}\): 3126, (NH), 1678, 1651 (2C=O), 1282, 1232 (3 OCH\({}_{3}\)) cm\({}^{-1}\). Anal. Calcd. for C\({}_{21}\)H\({}_{22}\)FN\({}_{3}\)O\({}_{5}\), %: C 60.72; H 5.34; N 10.12. Found: C 60.64; H 5.23; N 10.04. \(N^{\prime}\)-(4-methoxybenzylidene)-5-oxo-1(3,4,5-trimethoxyphenyl)pyrrolidine-3-carbohydrazide (**13**) White solid, yield 0.43 g (62%), m. p. 226-228 \({}^{\circ}\)C (from propan-2-ol). \({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\): 2.67-2.88 (m, 2H, CH\({}_{2}\)CO), 3.63, 3.76. 3.77 (3s, 9H, 3 CH\({}_{3}\)), 3.92-4.20 (m, 3H, NCH\({}_{2}\), CH), 6.89-7.10 (m, 4H, H\({}_{\rm Ar}\)), 7.64 (d, J = 8.0 Hz, 2H, H\({}_{\rm Ar}\)), 7.98 (s, 0.63H, CH=N), 8.16 (s, 0.37H, CH=N), 11.46 (s, 0.63H, CONH), 11.51 (s, 0.37H, CONH) ppm. \({}^{13}\)C NMR (101 MHz, DMSO-\(d_{6}\)) \(\delta\): 32.69, 34.72, 35.21, 35.76, 50.49, 51.05, 55.30, 55.91, 60.11, 97.84, 98.06, 114.32, 126.66, 126,73, 128.48, 128.71, 134.21, 134. \(N^{\prime}\)-(2,4-difluorobenzzylidene)-5-oxo-1-(3,4,5-trimethoxyphenyl)pyrrolidine-3-carbohydrazide **(14)**  
White solid, yield 0.6 g (86%), m. p. 179-181 \({}^{\circ}\)C (from propan-2-ol). \({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\): 2.71-2.88 (m, 2H, CH\({}_{2}\)CO), 3.63, 3.76.