## 4 Results
\begin{table}
\begin{tabular}{l c c c} \hline \hline \multicolumn{1}{c}{**Clinical Symptoms**} & **Abs.** & **P ES (\%)** & **95\% CI** \\ \hline Speech disorder & 33 & 63.5 & 56.82–70.18 \\ \hline Psychomotor agitation & 27 & 51.9 & 44.97–58.83 \\ \hline Impaired consciousness & 25 & 48.1 & 41.17–55.03 \\ \hline Impaired coordination & 17 & 32.3 & 26.19–39.21 \\ \hline Tremor & 16 & 30.8 & 24.4–37.2 \\ \hline Nystagmus & 11 & 21.2 & 15.54–26.86 \\ \hline Impaired eyesight & 7 & 13.5 & 8.77–18.23 \\ \hline Respiratory disorder & 6 & 11.5 & 7.07–15.93 \\ \hline Vomiting & 4 & 7.7 & 4.0–11.4 \\ \hline \multicolumn{4}{c}{Age: children older than 3 years (Number of cases = 39)} \\ \hline Focal neurological deficit: & 37 & 94.9 & 91.37–98.43 \\ - & Hemiplegia; & 6 & 16.2 & 10.14–22.26 \\ - & Hemiparesis. & 31 & 83.8 & 77.74–89.86 \\ \hline Headaches & 25 & 64.1 & 56.42–71.78 \\ \hline Psychomotor agitation & 20 & 51.3 & 43.3–59.3 \\ \hline Focal epileptic seizures & 18 & 46.2 & 38.22–54.18 \\ \hline Impaired consciousness & 16 & 41.0 & 33.12–48.88 \\ \hline Ataxia & 11 & 28.2 & 20.99–35.41 \\ \hline Nystagmus & 10 & 25.6 & 18.61–32.59 \\ \hline Vertigo & 8 & 20.5 & 14.03–26.97 \\ \hline Full or partial hemianopia & 7 & 17.9 & 11.75–24.05 \\ \hline Impaired speech & 7 & 17.9 & 11.75–24.05 \\ (dysarthria, aphasia) & & & \\ \hline \hline \end{tabular}
\end{table} 
Table 2: _Cont._scale confirmed the clinical neurological manifestations, enabling the recognition of mild and moderate forms of IS in most patients. Children presenting with sudden onset of general neurologic symptoms should undergo an immediate neurological examination to identify the following neurological symptoms: focal neurological symptoms, seizures associated with neurological symptoms, visual or speech disorders, mental disorders, impaired coordination or ataxia, headaches, and signs of intracranial tension. Urgent neuroimaging studies are essential in such cases, as these symptoms have a high significance as predictors for IS. Regarding the imaging aspects of IS, in addition to cerebral hypodensities observed through CT examination in neonates, other cerebral changes were also identified. These included myelination deficiency (\(n=11\); 15.5%; 95% CI [11; 21; 22; 23; 24; 25; 26; 27  
was performed, in most cases, within the first week, during the onset of disease symptoms (Table 4). The cerebral CT examination was not sufficient to establish the diagnosis, but it was helpful to clear concerns regarding the presence of a hemorrhagic stroke, tumor process, etc., and a brain MRI evaluation followed. This evaluation was performed in all 37 children (34.3%; 95% CI [29.73-38.87]) with suspected IS during the acute period of the disease. In all examined cases, ischemic lesions of various sizes were detected, characterized by a hypointense signal in T1 and a hyperintense signal in T2 (Table 5). Medium-sized ischemic lesions predominated in 46% of cases, while small or large lesions were observed in a smaller number of cases (24.3% and 29.7%, respectively). The distribution of ischemic foci according to size in the total study group, within the prospective study, is depicted in Figure 3. It is observed that medium-sized ischemic lesions were the most frequent type detected, with a slight predominance in the infant group. However, large-sized foci prevailed in the group of children older than 28 days, particularly in infants and those of young age. This trend was influenced by the characteristic etiologies associated with these age groups, often determined by infectious causes. In the cerebral MRI examination, in addition to the ischemic foci, other types of changes were also detected in some children, which possibly constituted a cause of IS or worsened the evolution of this disease.