## 2 Materials and Methods
### Synthesis of ligands
#### 2.2.8 2-(2-(2-(Pent-4-en-1-yloxy)ethoxy)ethoxy)ethyl-4-methylbenzenesulfonate **14**  
To a solution of compound **13** (1.62 g, 7421 mmol) and DMAP (0.148 mmol) in CH\({}_{2}\)Cl\({}_{2}\) (40 mL, \(\approx\)0.2 M), \(p\)-toluenesulfphonyl chloride (14.84 mmol) and Et\({}_{3}\)N (18.55 mmol) were added. The reaction was stirred at r.t. and followed by TLC (CH\({}_{2}\)Cl\({}_{2}\)/MeOH 9.5:0.5). After 10 h, TLC indicated the disappearance of the starting material, and 40 mL of water was added. The organic phase was separated and the aqueous phase was extracted thrice with CH\({}_{2}\)Cl\({}_{2}\). The combined organic phases were dried with Na\({}_{2}\)SO\({}_{4}\) and evaporated. The crude was purified by flash chromatography (silica gel, eluent CH\({}_{2}\)Cl\({}_{2}\)/MeOH 9.9:0.1), affording tosylate **14** (1976 g, 5.3 mmol, 72% yield). \({}^{1}\)H NMR (400 MHz, CDCl\({}_{3}\)) \(\delta\) 7.79 (d, J = 8.2 Hz, 2H, CH Ar), 7.33 (d, J = 8.0 Hz, 2H, CH Ar), 5.80 (ddt, J = 16.8, 10.1, 6.6 Hz, 1H, H4), 5.00 (dd, J = 17.1, 1.5 Hz, 1H, H5a), 4.94 (d, J = 9.4 Hz, 1H, H5b), 4.20-4.09 (m, 2H, -CH\({}_{2}\)CH\({}_{2}\)OTs), 3.72-3.64 (m, 2H, CH\({}_{2}\)CH\({}_{2}\)OTs), 3.64-3.52 (m, 8H, -CH\({}_{2}\)CH\({}_{2}\)O-), 3.45 (t, J = 6.7 Hz, 2H, H1a,b), 2.44 (s, 3H, CH\({}_{3}\)PhSO\({}_{3}\)), 2.10 (q, J = 7.2 Hz, 2H, H3a,b) and 1.72-1.60 (m, 2H, H2a,b). \({}^{13}\)C NMR (101 MHz, CDCl\({}_{3}\)) \(\delta\) 144.90 (Cq Ar), 138.36 (C4), 133.04 (Cq Ar), 129.92 and 128.08 (C Ar), 114.82 (C5), 70.86, 70.81, 70.74, 70.64, 70.17, 69.36 and 68.77 (CH\({}_{2}\)CH\({}_{2}\)O-), 30.32 (C3), 28.84 (C2) and 21.77 (CH\({}_{3}\)PhSO\({}_{3}\)). MS: \(m/z\) = 373.4 [M+H]\({}^{+}\). 2.2.9. 2-(2,3,4-Tri-O-benzyl-6-(2-(2-(2-(pent-4-en-1-yloxy)ethoxy)ethoxy)ethyl)-\(\alpha\)-D-glucopyranosyl)-1-azidoethane **15**  
Compound **12** (1024 mg, 2036 mmol) was dissolved in dry DMF (20 mL, 0.1 M) under argon and 3054 mmol of NaH (60% dispersion in mineral oil) was added at room temperature; after 10 min, a solution of toysolate **14** (3.9 mmol) in 5 mL of dry DMF was added dropwise. The reaction was stirred at r.t. under argon atmosphere and followed by TLC (Hexane/EtOAc 7:3). After 12 h, the reaction was quenched by adding some drops of MeOH; the mixture was diluted with water and extracted three times with EtOAc. The organic phase was dried over sodium sulfate, filtered and evaporated and the crude purified by flash chromatography (silica gel, eluent Hexane/EtOAc 7:3), affording 1065 g (1.7 mmol, 83% yield) of compound **15**. \({}^{1}\)H NMR (400 MHz, CDCl\({}_{3}\)) \(\delta\) 7.35-7.22 (m, 15H, CH Ar), 5.79 (ddt, J = 16.9, 10.1, 6.6 Hz, 1H, H10), 4.99 (dd, J = 17.1, 1.6 Hz, 1H, H11a), 4.93 (d, J = 12.0 Hz, 1H, H11b), 4.90 (d, J = 11.1 Hz, 2H, H1, CH\({}_{2}\)Ph), 4.84 (d, J = 10.9 Hz, 1H, CH\({}_{2}\)Ph), 4.79 (d, J = 10.9 Hz, 1H, CH\({}_{2}\)Ph), 4.69 (d, J = 11.6 Hz, 1H, CH\({}_{2}\)Ph), 4.63 (d, J = 11.0 Hz, 1H, CH\({}_{2}\)Ph), 4.59 (d, J = 11.6 Hz, 1H, CH\({}_{2}\)Ph), 4.15-4.05 (m, 1H, H1), 3.75-3.70 (m, 2H, H2, H3), 3.68-3.54 (m, 13H, H4, \(-\)CH\({}_{2}\)CH\({}_{2}\)O-), 3.54-3.47 (m, 3H, H5, H6a,b), 3.42 (t, J = 6.7 Hz, 2H, H7a,b), 3.39-3.25 (m, 2H, H2\({}^{2}\),a), 2.08 (dd, J = 14.2, 7.3 Hz, 2H, H9a,b), 1.99-1.89 (m, 2H, H1\({}^{1}\),a),b and 1.70-1.60 (m, 2H, H8a,b). \({}^{13}\)C NMR (101 MHz, CDCl\({}_{3}\)) \(\delta\) 138.70 (Cq Ar), 138.39 (C10), 138.34 (Cq Ar), 138.09 (Cq Ar), 128.58, 128.55, 128.50, 128.04, 128.01, 127.98, 127.88 and 127.74 (C Ar), 114.80 (C11), 82.31 (C3), 79.63 (C2), 77.98 (C4), 75.59 (CH\({}_{2}\)Ph), 75.16 (CH\({}_{2}\)Ph), 73.37 (CH\({}_{2}\)Ph), 71.67 (C1), 71.43 (C5), 71.10, 70.78, 70.73, 70.67, 70.59, 70.29 and 70.15 (C6, CH\({}_{2}\)CH\({}_{2}\)O-), 48.02 (C2\({}^{\prime}\)), 30.32 (C9), 28.84 (C8) and 24.47 (C1\({}^{\prime}\)). MS: \(m/z\) = 704.7 [M+H]\({}^{+}\). 2.2.10.