## 3 Synthesis Methods  
The reported methods in this review show that mixing AgNPs in monomer is the most frequently used method for synthesizing PMMA-AgNP composites independently of any kind of synthesized material (bone cement or denture base material). Another reported method includes the use of solvents and specialized equipment to form PMMA modified with silver nanoparticles, such as dimethyl-formamide, oleic acid, N-methyl pyrrolone and chloroform. This is done using a high-speed sonicator, as well as techniques such as cluster beam deposition and pulsed laser deposition. Methods reported are depicted in Table 1.  
Figure 1: PRISMA flow chart. \begin{table}
\begin{tabular}{c c c c c c c} \hline \hline
**Author,** & **Synthesis** & **Biocompatibility** & **Antimicrobial** & **Material** & **Application** \\
**Publication Year** & **Method** & **Test** & **Effect** & **Properties** & **Application** \\ \hline \multirow{9}{*}{[PERSON] et al., 2012 (16)} & Mixing powder & & & & & \\  & and monomer. & & & & & \\  & AgNPs were & & & & & \\  & synthesized by & & & & & \\  & adding silver & & & & & \\  & nitrate and & & & & & \\  & isopropyl alcohol & & & & & \\  & to monomer & & & & & \\ \hline \multirow{9}{*}{[PERSON] et al., 2014 (15)} & Mixing MMA & & & & & \\  & monomer with & & & & & \\  & AgNP & & test (MT) & & & \\  & suspension & & & & \\ \hline \multirow{9}{*}{[PERSON] et al., 2014 (9)} & Mixing acrylic & & & & & \\  & resin powder and & & & & & \\  & nano-silver in an & & & & & \\  & amalgamator & & & & & \\ \hline \multirow{9}{*}{[PERSON] et al., 2015 (11)} & Encapsulating & & & & Compression test, & \\  & AgNPs with oleic & Cell viability & Microbial & AFM, Inductively & \\  & acid and mixing & & test (MT) & & & coupled plasma & \\  & with PMMA & & & & & \\  & & & & & (ICP-MS) & \\ \hline \multirow{9}{*}{[PERSON] et al., 2015 (11)} & Dissolving & & & & & \\  & AgNO\({}_{3}\) with & & & & & \\  & n-methyl & & & & & \\  & pyrrolone and & & & & & \\  & mixing with & & & & & \\  & PMMA solution & & & & & \\  & in chloroform & & & & \\ \hline \multirow{9}{*}{[PERSON] et al., 2015 (17)} & Stirring AgNP & & & & UV & \\  & dispersion in & & & & spectrophotometry, & \\  & monomer & & & DSC, TGA, FTIR, & \\  & & monomer & & & swelling test, & \\  & & & & flexural strength & \\ \hline \multirow{9}{*}{[PERSON] et al., 2016 (13)} & Mixing MMA & & & & Nanofibers made & \\  & monomer with & & & by & \\  & AgNP & & & test & electrospinningming. & \\  & suspension & & & SEM and TEM & \\ \hline \multirow{2}{*}{[PERSON] et al., 2016 (3)} & Cluster beam & & & & \\  & deposition & & & & \\  & technique & & & & \\ \hline \multirow{9}{*}{[PERSON] et al., 2017 (7)} & & Cell viability & & SEM, inductively & \\  & Pulsed laser & test (MT), & Dynamic & coupled plasma & \\  & deposition (PLD) & necrosis & contact & mass & \\  & deposition by & detection by & conditions test & spectrometry & \\  & & flow cytometry & & & (ICP-MS) & \\ \hline \multirow{9}{*}{[PERSON] et al., 2018 (10)} & Mixing MMA & & & Quantification & \\  & monomer with & & & biomass & \\  & monomer with & & formation & & \\  & AgNP & & using Crystal & & \\  & suspension & & & & \\  & & & & \\  & & & & & \\  & & & & \\  & & & & & \\  & & & & \\  & & & & & \\  & & & & \\  & & & &The \"Material Properties\" column refers to the properties measured or tested in the PMMA\(-\)AgNP composites that claim to have dental applications. In this column, we also show different characterization methods. The aim of the table is to show different approaches that researchers used to synthetize and characterize these materials, as well as how their different properties, including flexural strength, flexural modulus and tensile strength, were tested. In the \"Antimicrobial Effect\" column, where we indicate whether reported papers on the use of PMMA and silver nanoparticles in forming materials for dental applications evaluated the antimicrobial effect.