## 1 Introduction
This study refers to synthesis and physico-chemical characterization of erythromycinomic-loaded poly (lactic acid) (PLA--Figure 2) and poly (lactic-co-glycolytic acid) (PLGA--Figure 3), as polymers chains are partitioned by hydrolysis into lactic and glycolytic acid natural metabolites, being then eliminated by citric acid cycle metabolic pathway. In the last few decades, both PLA and PLGA biopolymers have been studied for various medical and pharmaceutical applications, especially as drug delivery systems, as they proved high safety and excellent biocompatibility. An important issue of this work is the encapsulation of erythromycinocin active molecules into PLA and PLGA nanoparticles and their evaluation for further delivery to targeted site of infections [17; 18; 19; 20; 21; 22; 23; 24]. These antibiotic-loaded polymeric nanoparticle delivery systems improve the prevention and/or treatment of severe infections caused by antibiotic pathogen resistance by improving preparation methods, thus ensuring a drug release profile according to its action. Moreover, this approach includes erythromycinomycin as anti-infective agent knowing that, today, the medical field around the world is facing drug-resistant microorganisms. Prolonged and controlled release of encapsulated erythromycinocin consists of longer contact time in the circulatory system to prevent the multiplication of bacteria, especially multi-drug resistant ones, and to limit the side effects of the drug. The characterization of as synthesized samples was performed in this study to provide useful formulate for a prolonged and controlled drug release system in prevention and treatment of several infections. In addition to the obtained samples type drug delivery systems used in medicine, medical teams must have key communication skills effective in improving patient care. An extended approach for standardizing and improving communication, especially between disciplines, is the \"SBAR\" method (Situation, Background, Assessment, and Recommendation) [25; 26]. Interdisciplinary cooperation is important for obtaining new drug formulations in the context of reducing morbidity and mortality in healthcare facilities. An important goal of this research is to obtain a new polymer nanostructure loaded with antibiotics for  
Figure 3: Chemical structure of poly (lactic-co-glycolic acid), where x represents the number of lactic acid units, and y represents the number of glycolic acid units. Figure 2: Chemical structure of poly (lactic acid), where n represents the number of chains. the prevention and treatment of healthcare-associated infections. PLA/PLGA polymers are good candidates for drug carriers due to their biodegradability [27; 28]. A significant feature of these delivery systems is the disintegration kinetics, which can be prolonged for the sustained release of therapeutically agents, thus ensuring enough time for the drug to cause its effect [29; 30; 31; 32]. An important aspect in nanomedicine is the incorporation of the antibiotic in the polymeric structure of PLA and PLGA to limit the action of infectious agents. This work focused on preparing erythromycincom-loaded poly (lactic acid) (PLA) and poly (lactic-co-glycolic acid) (PLGA) and further evaluation of this broad spectrum curative agent encapsulated into polymer matrix.