# Therapeutic Potential of Polymer-Coated Mesoporous Silica Nanoparticles
## 2 Polymer Coated MSNs for Cancer
A remarkable antitumor activity was observed in C6 glioblastoma orthotopic rats when treated with ligand targeted hybrid carrier (tumor volume = \(27.43\pm 11.92\) mm\({}^{3}\)) compared to free arsenic trioxide (\(80.91\pm 13.45\) mm\({}^{3}\)) or with polymer coated MSNs (\(52.82\pm 10.82\) mm\({}^{3}\)) [42]. Figure 10: Graphical representation of the synthesis of PAA coated MSNs and their encapsulation in liposomes for glioma therapy [42]. \begin{table}
\begin{tabular}{l|l|l l l l} \hline
**Sr No** & **Investigators** & **Silica Core** & **Polymer Used** & **Drug** & **Application** \\ \hline
1 & [PERSON] et al. [20] & MSNs & Polydopamine & DOX & Cancer \\ \hline
2 & [PERSON] et al. [21] & Gold modified MSNs & Polydopamine & DOX & Cancer \\ \hline
3 & [PERSON] et al. [22] & MSNs & Polydopamine, PEG and EpCAM aptamer & DM-1 & Colorectal cancer \\ \hline
4 & [PERSON] et al. [26] & Mo6e2 wrapped MSNs & Polydopamine & DOX & Cancer \\ \hline
5 & [PERSON] et al. [27] & MSNs & Alpha-tocopherol) polyethylene glycol 1000 succinate & DOX & Cancer \\ \hline
6 & [PERSON] et al. [28] & KIL-2 and KIT-6 & k-Carrageenan and Chitosan & Curcumin & Cancer \\ \hline
7 & [PERSON] et al. [29] & MSNs & Folic acid modified Chitosan and hyaluronic acid & DOX & Cancer \\ \hline
8 & [PERSON] et al. [30] & MSNs & Chitosan & Gallic acid & Cancer \\ \hline
9 & [PERSON] et al. [31] & MSNs & Poly-(L-Histidine) and PEG & sorafenib & Cancer \\ \hline
10 & [PERSON] et al. [35] & Core-shell magnetic MSNs & Poly(N-isopropylacrylamide) (PNPAAm) & DOX & Cancer \\ \hline
11 & [PERSON] et al. [36] & MSNs & Poly(N-isopropylacrylamide-co-methacrylic acid) and & Evolamine and & Cancer \\  & & & DSPE-PExxx & & Berberine & Cancer \\ \hline
12 & [PERSON] et al. [37] & MSNs & Poly(L-lysine) and hyaluronic acid & Glucose Oxidase and & Cancer \\ \hline
13 & [PERSON] et al. [38] & MSNs & Sodium Alginate & DOX & Cancer \\ \hline
14 & [PERSON] et al. [39] & Fe0\({}_{4}\) core MSNs & Poly(ethyleneimine and Folic acid) & Edinburgh & Cancer \\ \hline
15 & [PERSON] et al. [43] & Gold core MSNs & Poly-2+ethyl-2-cavazoline & DOX & Cancer \\ \hline
16 & [PERSON] et al. [44] & MSNs & 4-(4,4,5,5-tetramethyl-1,3,2-dioxbordian-2-yl)benzyl & DOX & Cancer \\ \hline
17 & [PERSON] et al. [45] & MSNs & Lipid Galactosyl-Ceramide & Hydroxy-campothecine & Cancer \\ \hline
18 & [PERSON] et al. [46] & MSNs encapsulated in liposomes & Calcium Phosphate & DOX and Zinc & Cancer \\ \hline
19 & [PERSON] et al. [41] & Gold Nanoreds coated with Mesoporous silica & \(\beta\)-cyclodextrinutin and (2,3-dimethylmale anhydride & & \\  & & & modified chitosan oligosaccharide-b-poly(ethylene & Indocyanine Green dye & Cancer \\ \hline
20 & [PERSON] et al. [32] & Highly ordered MSNs & PEGylated Lipid bilayer & Paclitaxel and Curcumin & Cancer \\ \hline
21 & [PERSON] et al. [33] & Dendritic MSNs & Polyethyleneimine and Poly ethylene glycol & TNF-a & Cancer \\ \hline
22 & [PERSON] et al. [34] & Chlorin-e loaded MSNs & PEG & DOX & Cancer \\ \hline \end{tabular}
\end{table} 
Table 2: Tabular presentation of different coating materials used for MSNs along with their investigated applications.