## Appendix A  
This appendix section contains tables that provide a comprehensive list of _Camabis_ genes identified in the NCBI that are involved in key metabolic pathways. Table A1 presents genes associated with the biosynthesis of the aromatic amino acids phenylalanine and tyrosine, which serve as precursors for numerous specialized metabolites. Table A2 \begin{table}
\begin{tabular}{c c c c c c} \hline \hline \multirow{2}{*}{**Compound**} & **Range Levels** & **Mean Levels** & **Cultivar for Quantification** & **Tissue** & **Pharmacological Significance** & **Ref.** \\ \hline \multirow{4}{*}{Canniprene} & & & \multicolumn{2}{c}{Ermo} & & \\  & & & Carma & & Anti-inflammatory, \\  & 4–2085 & 433 &
\begin{tabular}{c} Carmagnola \\ THC-3 \\ MH-WU-112 \\ \end{tabular} & Leaf & antiproliferative, potential anti-viral activity & [57] \\  & & & MH-WU-112 & & & Anti-inflammatory \\ Cannabispirenone & - & - & & Leaf & Antiproliferative, cholesterol \\ HM1 & - & - & & & transport \\ HM2 & - & - & & Leaf & Antiproliferative, cholesterol \\ HM3 & - & - & & Leaf & Antiproliferative, cholesterol \\ \hline \hline \end{tabular}  
* For level comparison, cannabinoids such as THCA can attain concentrations of 300,000 mg/kg (30% m/m) in flowers. According to the SeedFinder database, Antal is an indica-dominant low-THC (0.2%) moderate-CBD (8%), hemp cultivar. Carmagnola is a sativa-dominant two-THC (0.5%) moderate-CBD (4%) bump cultivar. Kompelit is a sativa-dominant no-THC, high-CBD (14%) hemp cultivar. Tbroszallasi is a low-THC (<0.2%) low-CBD (2–3%), hemp cultivar. Zenith is a sativa-dominant low-THC (<0.02%) low-CBD (0.5%) hemp cultivar. According to [57], cultivars Ermo, Carmagnola, and MH-WU-112 are hemp fiber and CBD-chemotypes cultivars. Carma is hemp fiber CBC-chemotype cultivar. THC-3 is a narcite THC-chemotype cultivar. Their details were not found on the SeedFinder database.  
\end{table} 
Table 3: _Cont._details genes involved in the phenylpropanol pathway, including those responsible for the production of cinnamic acids and their amides, essential intermediates in lignin and flavonoid biosynthesis. Table 14 lists genes encoding enzymes for the biosynthesis of polyamines (spermine and spermidine) and spermidine-derived alkaloids, which play vital roles in plant growth and stress responses. Finally, Tables 15 and 16 highlight genes involved in flavonoid and stilbene biosynthesis pathways, respectively, which are pathways crucial for the production of bioactive compounds with diverse physiological and pharmacological properties. The sequencing of the _Cannabis_ genome, from which the genes mentioned below are sourced, was carried out by [PERSON]'s team in 2011 [133]. One ADH1 gene (LOC133033635) is not from the article produced by [PERSON] et al. (2011). Other sequences corresponding to phenylalanine ammonia lyase-like enzymes are also found in the NCBI, but these genes are not listed in the table above. The Cs4 CL4 mentioned in Section 3.6 corresponds to 4 CL2 in Table 17. The caffeine 3-O-methyltransferasease (COMT) genes encode for the enzymes capable of producing fertile acid, by methylating caffe acid. They are numerous in _Cannabis_, and they have notable variations between them at the protein level. This suggests that this gene has been the subject of duplication over time and that it is probably expressed in various tissues and with different regulations. We also find many COMT genes in the NCBI, with comparable sequences that have not yet been characterized. The search for spermidine-hydroxycinnamoyl transferase in the NCBI gives several results, including spermidine coumaroyl-CoA acyltransferases and proteins that are spermidine-hydroxycinnamoyl transferase-like. These are listed in Table 14. It is likely that there are many of these spermidine-hydroxycinnamoyl transferase-like proteins, as they have not yet been characterized enzymatically, and do not necessarily use spermidine as a substrate.