# Effectiveness of High-Intensity Therapy in Rehabilitation of Parkinson's Disease Patients
## 4 Results
### Functional Outcomes and Quality of Life Measures  
The impact of different therapy modalities on functional outcomes and quality of life in patients with Parkinson's disease was assessed using standardized evaluation measures. Significant improvements were observed across all therapy groups in the UPDRS (Unified Parkinson's Disease Rating Scale), with \(p<0.0001\), indicating that the interventions effectively enhanced motor function and daily life activities. The Berg Balance Scale analysis demonstrated notable improvements in balance control, particularly in the Agility and Robot therapy groups, which exhibited the largest effect sizes (\(p<0.0001\)). Furthermore, the Schwab and England Independence Scale results showed significant differences in functional independence levels across therapy groups (\(p=0.0045\)), highlighting the effectiveness of rehabilitation programs in maintaining autonomy in daily activities. In addition to motor function and independence, the psychological and emotional well-being of participants improved significantly post-intervention. The Beck Depression Inventory revealed substantial reductions in depression scores (\(p<0.001\)), indicating that engaging in high-intensity exercise programs had a positive impact on mental health. Similarly, the PDQ-39 Emotional Well-Being domain analysis confirmed significant improvements in mood and emotional stability (\(p=0.0005\)), further supporting the benefits of therapy in enhancing the overall quality of life. To determine the clinical relevance of observed improvements, we compared the average pre-post changes with established Minimal Clinically Important Difference (MCID) and Minimum Detectable Change (MDC) values for key outcomes: A gait speed improvement of \(\geq\)0.10 m/s is considered clinically meaningful in patients with PD; our study found gains of 0.40-0.54 m/s across all groups, exceeding this threshold. The Functional Independence Measure (FIM) showed an average increase of 25-30 points, well above the 22-point MCID commonly cited for PD populations. Improvements on the Berg Balance Scale (BBS) exceeded the 5-point MDC threshold in all groups, indicating real functional gains. The Tinetti Assessment Tool scores improved beyond the 3-4 point MDC range, supporting the clinical validity of balance changes. On the Falls Efficacy Scale, a change of \(\geq\)11 points is considered clinically meaningful; our data showed changes of 16-23 points. These findings confirm that the statistical significance observed throughout the analysis is supported by meaningful, clinically relevant improvements in functional performance and patient safety indicators. See Table 4 for a detailed summary of the MCID/MDC thresholds and the observed clinical improvements across groups.  
\begin{table}
\begin{tabular}{c c c c} \hline \hline
**Outcome Measure** & **MCID/MDC Threshold** & **Observed Mean Change** & **Clinically Meaningful?** \\ \hline
10 MWT (m/s) & \(\geq\)0.10 m/s & +0.46 m/s & Yes \\ \hline
6 MWT (m) & \(\geq\)50 m & +142.1 m & Yes \\ \hline FIM (total) & \(\geq\)22 points & +24.7 points & Yes \\ \hline FIM (motor) & \(\geq\)17 points & +22.8 points & Yes \\ \hline BBS & \(\geq\)5 points & +8.6 points & Yes \\ \hline Tinetti & \(\geq\)2.9 points & \(-\)3.4 points & Yes \\ \hline \hline \end{tabular}
\end{table}
Table 4: Summary of MCID/MDC thresholds and observed mean changes in key outcomes.