# Common Molecular Mechanisms and Biomarkers in Breast, Colon and Ovarian Cancer
## 3 Results
### Identification of Common Proteins
\begin{table}
\begin{tabular}{c c} \hline
**Protein** & **Description—Functions** \\ \hline CHEK2 & Serine/threonine-protein kinase Chk2—Cell cycle arrest; activation of DNA repair and apoptosis \\ \hline CTNNB1 & Catenin beta-1—Promotes phosphorylation and ubiquitination promoting degradation by the proteasome; regulation of cell adhesion \\ \hline ERBB2 & Receptor tyrosine-protein kinase erbB-2—Regulates outgrowth and stabilization of peripheral microtubules \\ \hline IDH2 & Isocitrate dehydrogenase [NADP], mitochondrial—Intermediary metabolism and energy production \\ \hline KIT & Mast/stem cell growth factor receptor Kit—Cell surface receptor; regulation of cell survival and proliferation; hematopoiesis; stem cell maintenance; gametogenesis; mast cell development; migration; melanogenesis \\ \hline KRAS & GTPase KRas, N-terminally processed—GTPase activity; regulation of cell proliferation; promoting oncogenic events \\ \hline KRT7 & Keratin, type II cytoskeletal 7—Blocks interferon-dependent interphase; stimulates DNA synthesis; regulation of the human papillomavirus type 16 E7 mRNA \\ \hline MDM2 & E3 ubiquitin-protein ligase Mdm2—Ubiquitination of p53/TP53 for degradation; inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis; nuclear export of p53/TP53; promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein; inhibits DAXX-mediated apoptosis \\ \hline MLH1 & DNA mismatch repair protein Mlh1—Component of the post-replicative DNA mismatch repair system (MMR); generates new entry points for the exonuclease EXO1 to degrade the DNA strand \\ \hline MSH2 & DNA mismatch repair protein Msh2—Component of the post-replicative DNA mismatch repair system (MMR); binds to DNA mismatches initiating DNA repair \\ \hline MSH6 & DNA mismatch repair protein Msh6—Component of the post-replicative DNA mismatch repair system (MMR); binds to DNA mismatches initiating DNA repair \\ \hline MYC & Myc proto-oncogene protein—Binds DNA; activates the transcription of growth-related genes; promotes angiogenesis; regulator of somatic reprogramming; controls self-renewal of embryonic stem cells; activates target gene expression \\ \hline PARP1 & Poly [ADP-ribose] polymerase 1—Plays a key role in DNA repair \\ \hline PIK3 CA & Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform—Activates signaling cascades involved in cell growth, survival, proliferation, motility, and morphology \\ \hline PTEN & Phosphatase and tensin homolog—Tumor suppressor; acts as a dual-specificity protein phosphatase; acts as a lipid phosphatase \\ \hline RABL3 & Rab-like protein 3—Member of RAS oncogene family like 3; belongs to the small GTPase superfamily \\ \hline RNF43 & E3 ubiquitin-protein ligase RNF43—Negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex \\ \hline SMAD4 & Mothers against decapentaplegic homolog 4—In muscle physiology, plays a central role in the balance between atrophy and hypertrophy; acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression \\ \hline \end{tabular}
\end{table} 
Table 2: Cont.