# Personalized Bone Reconstruction and Regeneration in the Treatment of Craniosomiasis
### Craniosynostosis: A Heterogeneous Condition
\begin{table}
\begin{tabular}{c c c c} \hline \hline \multirow{2}{*}{**Syndrome(s) or Phenotype**} & **OMIM ID and/or PubMed** & **Involved Suture(s)** & **Gene** \\  & **Reference** & **Symbol** & **Symbol** \\ \hline SPONDYLOEPIIHYSEAL & & & \\ DYSPLASIA WITH CORONAL & & & \\ CRANIOSYNOSTOSIS, & 602611 & Coronal & - \\ CATARACTS, CLEFT PALATE, & & & \\ AND MENTAL RETARDATION & & & \\ STRUCTURAL BRAIN & & & \\ ANOMALIES WITH IMPAIRED & & & \\ INTELECTUAL & 618736 & Coronal & _ZIC1_ \\ DEVELOPMENT AND & & & \\ CRANIOSYNOSTOSIS & & & \\ \hline SUMMITT SYNDROME & 272350 & - & - \\ \hline SWENEY-COX SYNDROME & 617746 & Variable & _TWIST1_ \\ \hline SYNDACTYLY, TYPE 1, WITH & & & \\ OR WITHOUT & 185900 & Sagittal & IHH \\ CRANIOSYNOSTOSIS & & & \\ TETRASOMY 15Q26 & 614846 & \
\begin{tabular}{c} Metopic, coronal, \\ multisuture \\ \end{tabular} & 15q26-qter a \\ \hline THANATOPHORIC DYSPLASIA, & 187600 & - & _FGFR3_ \\ TYPE I & & & \\ TOE SYNDACTY, & & & \\ TELEVANTHUS, AND & & & \\ ANOGENTIAL AND RENAL & & & \\ MALFORMATIONS & & & \\ TREACHER COLLINS & 154500 & Multisuture & TCOF1 \\ SYNDROME 1 & & & \\ \hline TRICHOTHIOYSTROPHY 6, & & & \\ NONPHOTOSENSITIVE & 616943 & Coronal & _GT2E2_ \\ \hline TRIGONOCEPHALY 1 & 190440 & Multisuture & _FGFR1_ \\ \hline TRIGONOCEPHALY 2 & 614485 & Metopic & _FREM1_ \\ \hline TRIGONOCEPHALY WITH & & & \\ SHORT STATURE AND & 314320 & Metopic & - \\ DEVELOPMENTAL DELAY & & & \\ \hline UNDEFINITED/UNCLEAR & 600921 & Sagittal & _FGF9_ \\ \hline UNDEFINITED/UNCLEAR & 610966 & Multisuture & _FTO_ \\ \hline UNDEFINITED/UNCLEAR & 147370 & Sagittal, coronal & _IGF1R_ \\ \hline UNDEFINITED/UNCLEAR & 600727 & Metopic & _NFIA_ \\ \hline UNDEFINITED/UNCLEAR & 611909 & - & _FNDC3B_ \\ \hline [PERSON] & & & \\ SYNDROME & 600920 & Multisuture & _SCARF2_ \\ \hline WEISS-KRUSZKA SYNDROME & 618619 & Metopic & _ZNF462_ \\ \hline WILLIAMS-BEUREN & 194050 & Sagittal & 7q11.23 a \\ SYNDROME & 617140 &
\begin{tabular}{c} Metopic, sagittal, \\ multisuture \\ \end{tabular} & _SON_ \\ \hline \hline \end{tabular}  
* Cytogenetic location.  
\end{table} 
Table 1: _Cont._ \begin{table}
\begin{tabular}{c c c c} \hline \hline
**Syndrome(s) or** & **OMIM ID/** & **Involved Suture(s)** & **Gene Symbol** \\
**Phenotype** & **Reference** & **Involved Suture(s)** & **Gene Symbol** \\ \hline Craniosynostosis, & & & \\ nonsyndromic & [35] & Coronal & _FGFR2_ \\ \multicolumn{3}{c}{uncoronal} \\ \hline Nonsyndromic & [36] & - & _SNAII_ a \\ craniosynostosis & [37] & - & _PTH2R_ (_intron break_) \\ \hline Nonsyndromic & [17] & Coronal & _FFNB1_ a \\ craniosynostosis & [17] & Sagittal & _ALX4_ a \\ \hline Nonsyndromic & [17] & Sagittal, coronal & _TWIST1_ a (c.435C\textgreater{}C) \\ craniosynostosis & [17] & Coronal & _TWIST1_ a (c.421G\textgreater{}C) \\ \hline Nonsyndromic & [17] & Sagittal & _ADCK1_ a \\ craniosynostosis & [17] & Sagittal & _ALPL_ a \\ \hline Nonsyndromic & [17] & Sagittal & _BMPER_ a \\ craniosynostosis & [17] & Sagittal, coronal & _FREM1_ a \\ \hline Nonsyndromic & [17] & Sagittal, coronal & _FREM1_ a \\ craniosynostosis & [17] & Coronal & _JAG1_ a \\ \hline Nonsyndromic & [17] & Coronal & _NELL1_ a \\ craniosynostosis & [17] & Sagittal & _NOTCH_1 a \\ \hline Nonsyndromic & [17] & Sagittal & _NOTCH_2 a \\ craniosynostosis & [17] & Sagittal & _PDIIT_ a \\ \hline Nonsyndromic & [17] & Sagittal & _REQ4_ a \\ craniosynostosis & [17] & Coronal & _SHC4_ a \\ \hline Nonsyndromic & [17] & Sagittal & _TGFR2_ a \\ craniosynostosis & [38] & Metopic & _RUNX2_ b \\ \hline Nonsyndromic & [18] & Metopic & _ARAP3_ \\ craniosynostosis & & & \\ \hline \hline \end{tabular}
\end{table} 
Table 2: Nonsyndromic Craniosynostosis and associated genes.