## 3 Materials and Methods
### Materials  
26-bromo-2,5,8,11,14,17,20-heptaoxahexacosane (Eg\({}_{6}\)C\({}_{6}\)Br)  
To a solution of 1,6-dibromohexane (5.93 mL, 39.1 mmol) and 60% sodium hydride (0.939 g, 23.5 mmol) in 8.5 mL THF was added dropwise to a solution of hexaethylene glycol monomethyl ether (2.32 g, 7.83 mmol) in 8.5 mL THF while stirring in an ice bath, and the mixture was stirred overnight at room temperature. The resulting solution was diluted with a mixture of MeOH and saturated ammonium chloride aqueous solution and then extracted three times with Et\({}_{2}\)O. The combined organic phases were dried over MgSO\({}_{4}\) and evaporated. The resulting residue was chromatographed on silica gel with n-hexane/AcOEt (100:5-100:30) as the eluent to afford **Eg\({}_{6}\)C\({}_{6}\)Br** as a colorless oil in 81.9% yield (2.95 g, 6.42 mmol). \({}^{1}\)H NMR (CDCl\({}_{3}\), 270 MHz) \(\delta\) 3.63-3.26 (_m_, 24H), 3.59-3.53 (_m_, 2H), 3.46 (_t_, \(J\) = 6.8 Hz, 2H), 3.38 (_s_, 3H), 1.89-1.81 (_m_, 2H), 1.62-1.57 (_m_, 2H), 1.40-1.36 (_m_, 4H). The \({}^{1}\)H NMR spectrum was consistent with that previously reported [19]. 27-bromo-2,5,8,11,14,17,20-heptaoxaheptacosane (Eg\({}_{6}\)C\({}_{7}\)Br)  
**Eg\({}_{6}\)C\({}_{8}\)Br** was prepared in a manner similar to that described for **Eg\({}_{6}\)C\({}_{6}\)Br**, using dibromoheptane instead of dibromohexane. The reaction yield was 66.4%. \({}^{1}\)H NMR (CDCl\({}_{3}\), 500 MHz) \(\delta\) 3.53-3.49 (_m_, 22H), 3.47-3.46 (_m_, 2H), 3.44-3.42 (_m_, 2H), 3.38 (_t_, \(J\) = 2.5 Hz, 2H), 3.23 (_s_, 3H), 1.49-1.46 (_m_, 2H), 1.37-1.36 (_m_, 2H), 1.30-1.27 (_m_, 6H). HRMS (ESI) Calcd. for C\({}_{20}\)H\({}_{41}\)BrNaO\({}_{7}\) [M + Na]\({}^{+}\): _m_/2 495.1833, Found: 475.1819. 28-bromo-2,5,8,11,14,17,20-heptaoxaoctacosane (Eg\({}_{6}\)C\({}_{8}\)Br)  
**Eg\({}_{6}\)C\({}_{8}\)Br** was prepared in a manner similar to that described for **Eg\({}_{6}\)C\({}_{6}\)Br**, using dibromooctane instead of dibromohexane. The reaction yield was 67.7%. \({}^{1}\)H NMR (CDCl\({}_{3}\), 500 MHz) \(\delta\) 3.65-3.64 (_m_, 20H), 3.58-3.54 (_m_, 4H), 3.46-3.39 (_m_, 4H), 3.38 (s, 3H), 1.88-1.82 (_m_, 2H), 1.60-1.54 (_m_, 2H), 1.46-1.38 (_s_, 2H), 1.31 (_m_, 6H). HRMS (ESI) Calcd. for C\({}_{21}\)H\({}_{43}\)BrNaO\({}_{7}\) [M + Na]\({}^{+}\): _m_/2 509.2090, Found: 509.2046. 2-(2,5,8,11,14,17,20-heptaoxahexacosan-26-yl)bisiondoline-1,3-dione (Eg\({}_{6}\)C\({}_{6}\)NPht)  
A mixture of **Eg\({}_{6}\)C\({}_{6}\)Br** (2.94 g, 6.40 mmol) and potassium phthalimide (1.30 g, 7.04 mmol) in 49.3 mL DMF was stirred at 110 \({}^{\circ}\)C for 4 h. After cooling to room temperature, the resulting solution was evaporated and diluted with water. The obtained mixture was extracted three times with Et\({}_{2}\)O and the combined organic phases were dried over MgSO\({}_{4}\) and evaporated to afford **Eg\({}_{6}\)C\({}_{6}\)NPht** as a colorless oil in 73.5% yield (2.47 g, 4.70 mmol). IR (Neat on NaCl) 3465, 2932, 2862, 1716, 1606, 1459, 1399, 1360, 1302, 1251, 1104, 721 cm\({}^{-1}\). \({}^{1}\)H NMR (CDCl\({}_{3}\), 270 MHz) \(\delta\) 7.86-7.83 (_m_, 2H), 7.72-7.69 (_m_, 2H), 3.70-3.61 (_m_, 2H), 3.58-3.53 (_m_, 4H), 3.46-3.41 (_t_, \(J\) = 6.75 Hz, 2H), 3.38 (_s_, 3H), 1.70-1.65 (_m_, 4H), 1.59 (_m_, 2H), 1.38-1.36 (_m_, 4H). The \({}^{1}\)H NMR spectrum was consistent with that previously reported [19]. 2-(2,5,8,11,14,17,20-heptaoxaheptacosan-27-yl)isoindoline-1,3-dione (Eg\({}_{6}\)C\({}_{7}\)NPht)  
**Eg\({}_{6}\)C\({}_{7}\)NPht** was prepared in a manner similar to that described for **Eg\({}_{6}\)C\({}_{6}\)NPht**, using **Eg\({}_{6}\)C\({}_{7}\)Br** instead of **Eg\({}_{6}\)C\({}_{6}\)Br**. The reaction yield was 76.7%. IR (neat on NaCl) 3517, 2930, 2863, 1771, 1713, 1635, 1467, 1438, 1396, 1369, 1108, 722 cm\({}^{-1}\).