## 1 Introduction
The subsequent phenylpropanoic acids (contirely) aldehyde, cinnamaldehyde, sinyapaldehyde, estragole, eugenol, and methyleugenol) exhibited lower anticandidal efficacy (with MIC values exceeding 100 \(\upmu\)g/mL). The neoligans (honokiol, magnolol, or glochidiboside) at MICs of 3.3-25 \(\upmu\)g/mL also possessed an inhibitory effect toward _Candida_ strains [14]. There are several reports of significant antifungal activity of quinones, such as purpurin, aloemodin, shikonin, or menadione (MIC = 1.28-15.6 \(\upmu\)g/mL). The anticandidal effect also showed flavonoids: baicalein, mycretin, sequocretin, quercetin, kaempfer, derrone, and licoflavone C (MICs of 1.9-64 \(\upmu\)g/mL). Additionally, the promising effect against _C. albicans_ indicated ruin, papyriflavonol A, pinocembrin, genistein, silibinin, and alpinetin (MIC = 6.25-32 \(\upmu\)g/mL). Moreover, some alkaloids have strong activity toward _Candida_ spp., especially tylophorinine hydrochloride, vincamine, trigonelline (MIC = 0.6-8 \(\upmu\)g/mL), and tetrandrine (MIC = 32 \(\upmu\)g/mL). The anti-_Candida_ activity of other alkaloids (berberine, roemerine, or matrine) was also reported [14]. In addition, there are also many studies on the antifungal effect of terpen and terpenoids. Among them, laurepoxyene and laurokamurene C possessed potent anticandidal activity even at MICs of 1-2 \(\upmu\)g/mL and plumericin or its isomers at MICs < 4 \(\upmu\)g/mL. Hinokitiol, rubiarbonol G and retigeric acid B inhibited growth of _C. albicans_ strains at MIC = 5-16 \(\upmu\)g/mL. Isopimaric acid and some diterpenoids (MIC = 15-18 \(\upmu\)g/mL), or pseudolaric acid B (MICs of 16-128 \(\upmu\)g/mL) were also active against _Candida_ spp. In turn, linalool, carvacrol, thymol, citral, geraniol, citronellol, and citronellal were responsible for the anti-_Candida_ activity of the essential oils (EOs) from many plants [14]. Therefore, it would be an excellent idea to use EOs and their selected constituents to develop new potential phytopharmaceuuticals with antifungal effect. EOs are well-known as agents with broad-spectrum activity. They are rich mixtures of different substances, including terpenes (monoterpenes, e.g., linalool, thymol, menthol, geraniol, and sesquiterpenes), terpenoids, alcohols, phenols, aldehydes, ketones, esters, ethers, and other components with low molecular weights produced by aromatic plants [5; 16]. One type of EO may contain even over 100 various compounds in different ratios (1-70%) with 2-3 main components constituting 20-70% of the total composition [5; 14; 17; 18]. Linalool (LIN), also known as 3,7-dimethyl-1,6-octadian-3-ol (C\({}_{10}\)H\({}_{18}\)O), is an unsaturated aliphatic alcohol belonging to the terpene group--monoterpene [19; 20; 21; 22; 23; 24]. It is a volatile flavor compound which is produced by over 200 plants worldwide (lavender, basil, co-riander, jasmine, rosewood, linaloe, rosemary, rose, petitgrain, and bergamot) and isolated from their flowers, leaves, herbs, seeds, and wood [20; 22; 25]. LIN was approved by the Food and Drug Administration (FDA) as Generally Recognized as Safe (GRAS) [1; 19; 25; 26; 27]. Therefore, it is widely use in various industry sectors, including the food as well as the perfume, cosmetic, and pharmaceutical industries [23; 24; 25]. This terpen and EOs rich in LIN exhibit various biological activities, including antimicrobial [1; 20; 22; 24; 28; 29], anti-inflammatory [1; 19; 21; 22; 23; 24; 28], antioxidant [20; 21; 24], anticancer [20; 21; 23; 28; 29], antiplasmodal [19; 22], antinociceptive [1; 19; 22; 28], antihypersigc, or antihyperlipidemic [19; 22]. LIN is also known as an intermediate in the biosynthesis of vitamins A and E [19; 20; 22; 30]. In addition, it prevents complications in diabetes, atherosclerosis of the coronary arteries, Alzheimer's disease, and aging processes [25]. Its anxiolytic, antidepressive, and neuroprotective activities were also demonstrated in several studies [28; 29].