## 4 Discussion  
Attempts to the use suPAR markings to predict the progress of severe diseases are made in general surgery [9; 10] due to CRP, one of the most frequently assessed parameters, is nonspecific and its elevation is observed after 48 h [11] from the onset of symptoms, which can delay implementation of appropriate treatment. Therefore, there is a need for the detection of a new parameter of inflammation that could be applied as a rapid marker in the early prognosis of the course of severe complications [10]. In the pleural infection, suPAR has been shown to be potentially used in predicting of the need for tube thoracostomy in parapneumonic effusions [9; 12]. Next, in renal injury [13] and other diseases [14] suPAR is known diagnostic marker. Intestinal inflammations in HIV-positive patients [15], acute pancreatitis and its progress prediction [10] also may by assessed with the use of suPAR. Additionally, in patients of advanced age [16], with renal insufficiency [17] and heart disease [18] the protein was studied. Its prognostic potential was also raised here. It is precisely these hidden deficiencies of the internal organs that may give rise to unexpected complications in patients after scheduled maxillofacial surgery. The most frequent complication in maxillao-facial surgery is inflammation. The traditional anti-inflammatory and at the same time anti-infective treatment, i.e., antibiotic prophylaxis, is sometimes supplemented with topical anti-infective agents [19]. Nevertheless, inflammatory complications are still unavoidable and increasingly sophisticated methods such as neural networks are being used to predict complications [20; 21], as was done in this study. When considering the causes of complications, it is important to point out the significant shortcomings in their diagnosis in everyday hospital practice where markers of metalloproteinase activity and mitochondrial enzymes are not routinely used. The use of the fixative material itself and especially its effect on the tissue environment is debatable. On the one hand, negative effects in the form of oxidative and nitrosative stress are observed [22; 23], while on the other hand, macrophage function is properly preserved [24]. Figure 6: Application of fuzzy mathematics for predicting minor complications after maxillofacial surgery procedures. Pre-operational IBI higher values (i.e., 3.5–4.3) protect patients from postoperative complications. (**a**) Prediction with the evaluation of Glycemia and Chlorides concentration assessment in blood serum; (**b**) based on IBIpre and Chlorides; (**c**) based on IBIpre and Glycaemia; (**d**) based on IBIpre an ALT + Alb + Hb Factor originated from Factor Analysis. Therefore, it seems appropriate to search for new predictive factors of successful treatment and/or indicating the risk of complications. At the same time, general intrinsic factors, sex, place of residence, addictions and habits exert a influence on bone mineral content in the facial skeleton and its local immunity [25]. Thus, a great field of unknowns regarding the scheduled patient remains unexplained. Having a marker of overall immune system efficiency to predict even minor postoperative complications would be very valuable. The use of the suPAR study to predict mild inflammatory complications, that are not life-threatening [26], requires a different approach than that published in the literature to date. This is related to the impossibility of obtaining a classical cut-off point, e.g., 4.75 ng/mL as in the case of patients entering into severe pancreatitis [10]. These authors also noted that predicting the development of moderate inflammatory process and its separation from mild process is already more difficult (although they give a limit of 3.65 ng/mL, it is less certain). Multiorgan failure was predicted in severe inflammation at 5.2 ng/mL and the risk of death (already more difficult to predict and less certain) from 7.05 ng/mL.