## 3 Chemical Composition of _Hyssopus officinalis_ L. and _Agastache foeniculum_ (Pursh) Kuntze EOs
### Chemical Composition of Agastache foneticulum (Pursh) Kuntze EO  
The volatile compounds of _A. foneiculum_ (Pursh) Kuntze EO are listed in Table 4. The EO constituents are categorized as phenylpropanoids, (22.39-84.67%) [17; 19], monoterpene hydrocarbons (2.4-10.23%) [19; 41], oxygenated monoterpenes (0.08-54.51%) [17; 19], sesquiterpene hydrocarbons (1.8-19.19%) [17; 41], and oxygenated sesquiterpennes (0.2-3.96%) [17; 41]. Figure 4 presents the distribution of these main classes of EO. Also, some researchers reported benzenoid aromatics (approximately 90%) or oxygenated aliphatics. \begin{table}
\begin{tabular}{c c c c c} \hline \hline
**Total Number of** & \begin{tabular}{c} **Total** \\ **Identified** \\ **Compounds** \\ **(\%)** \\ \end{tabular} & \
\begin{tabular}{c} **Main Classes** \\ **of Compounds** \\ **(\%)** \\ \end{tabular} &
\begin{tabular}{c} **Main Compounds** \\ **(\%)** \\ \end{tabular} & **Reference** \\ \hline
7 & 99.99 & NM &
\begin{tabular}{c} **Estragole: 94.89;** \\ **Limonene: 2.91** \\ \end{tabular} & [16] \\ \hline
12 & 99.26 & NM &
\begin{tabular}{c} **Estragole: 94;** \\ **1,8-Cineole: 3.33** \\ \end{tabular} & [44] \\ \hline
7 & 95.4 & NM & \begin{tabular}{c} **Estragole: 83.;** \\ **Limonene: 3.4;** \\ **Spathulenol: 3.1;** \\ **Caryophyllene oxide: 3.1** \\ \end{tabular} & [40] \\ \hline EO1: 31 & 1000 & 1000 & 1000 & 1000 \\ EO2: 45 & 1000 & 1000 & 1000 & 1000 \\ EO3: 44 & \begin{tabular}{c} **Monoterpene hydrocarbons**: \\ EO1: 2.4, EO2: 4.9, EO3: 2.9** \\ **Oxygenated monoterpencids**: \\ EO1: 1.0, EO2: 0.1, EO3: 0.1 \\ **Sesquiiterpene hydrocarbons**: \\ EO2: 45 & 100 & 1000 & 1000 \\ EO3: 44 & \
\begin{tabular}{c} **Crystalened sesquiterpennoids**: \\ EO1: 0.2, EO2: 0.2, EO3: 0.3 \\ **Benzenoid aromatics**: \\ EO1: 94.1, EO2: 91.3, EO3: 92.9 \\ **Others**: EO1: 0.5, EO2: 1.0, EO3: 0.9 \\ \end{tabular} &
\begin{tabular}{c} **Estragole: EO1: 93.2, EO2: 88.4,** \\ EO3: 91.5;** \\ **Limonene: EO1: 1.5, EO2: 4.9,** \\ EO3: 2.9;** \\ **Benzenoid**: 1.2,** \\ EO2: 1.6, EO3: 1.9 \\ \end{tabular} \\ \hline \hline \end{tabular}
\end{table} 
Table 4: Volatile compounds of _Agastache foneiculum_ (Pursh) Kuntze EO. Figure 3: The chemical structures of the main compounds of _H. officinalis_ EO (created with BioRender. com; accessed on 2 April 2025). The high amount of phenylpropanoids can be explained through the concentrations of estragole or methyl chavicol (3.2-94.89%) [16; 42], methyl eugenol, eugenol, and methyl isoeugenol. Some authors reported a high amount of oxygenated monoterpene methone (31.58-34.3%) [17; 42]. Limonene is the most representative compound (1.5-9.9%) [19; 41] from the monoterpene hydrocarbons class; meanwhile, \(\beta\)-caryophyllene is the most common compound from the sesquiterpene hydrocarbon group. Caryophyllene oxide and spathulenol are the most representative of the oxygenated sesquiterpene class. The chemical structures of the main compounds are presented in Figure 5.  
\begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Total Number of** & \begin{tabular}{c} **Total** \\ **Identified** \\ **Compounds** \\ **(\%)** \\ \end{tabular}  & \ \begin{tabular}{c} **Main Classes** \\ **of Compounds** \\ **(\%)** \\ \end{tabular}  & \begin{tabular}{c} **Main Compounds** \\ **(\%)** \\ \end{tabular}  & **Reference** \\ \hline
13 & 100 & \begin{tabular}{c} **Oxygenated aliphatics: 1.98** \\ **Monoterpene hydrocarbons**: 10.23 \\ **Oxygenated monoterepenes**: 0.08 \\ **Sesquietpene hydrocarbons**: 3.04 \\ **Phenylpropanoids**: 84.67 \\ \end{tabular}  & \begin{tabular}{c} **Methyl chavicol**: 82.03 \(\pm\) 0.80; \\ **Limonene**: 9.90 \(\pm\) 0.09; \\ **-Caryophyllene**: 2.35 \(\pm\) 0.02; \\ **1-Octen-3-ol, acetate**: 1.84 \(\pm\) 0.01 \\ \end{tabular}  & \ \begin{tabular}{c} **Methyl chavicol**: 82.03 \(\pm\) 0.80; \\ **Limonene**: 9.90 \(\pm\) 0.09; \\ **-Caryophyllene**: 2.35 \(\pm\) 0.02; \\ **1-Octen-3-ol, acetate**: 1.84 \(\pm\) 0.01 \\ \end{tabular}  & \begin{tabular}{c} **[19]** \\ **-Octen-3-ol, acetate**: 1.84 \(\pm\) 0.01 \\ \end{tabular}