## 3 Results and Discussion
### Bioactivities
#### 3.2.3 Antimicrobial Bioactivity  
This bioactivity can be explored alone or even in parallel to others. For instance, if the target patients with neurodegenerative diseases need to be medicated with corticosteroids, which induce an immunodepression effect that makes them more vulnerable to infections, a molecule that accumulates acetylcholinesterasecholinesterase inhibition and activity against the most common bacteria and yeasts will improve the therapy [39]. Therefore, to complete the bioactivities for these extracts, we chose this last bioactivity, which will contribute better performance to further studies of the compounds in the extracts. The extracts were screened for the antimicrobial activity for various microorganisms _E. coli_ ATCC 29998 TM, _Staphylococcus aureus_ ATCC 43300 TM, _Candida albicans_ ATCC 10231 TM, _E. coli_ ESA37, _S. aureus_ ATCC ESA111 and amphotericin-B-resistant _Candida albicans_ ESA 100 were tested. The minimum inhibitory concentration of the _A. dealbata_ flower extracts with different maturation stages is shown in Table 4.  
The results shown in Table 5 report the higher effects of the region and maturation status on the antimicrobial bioactivity. Once again, the extracts from the EF harvested in region A gave the best activity. It seems that maybe a possible change occurred due to the different climatic conditions, soils or other factors. The effect of the harvest place should be explored more in future research designed with this purpose. \begin{table}
\begin{tabular}{c c c c c c c c} \hline \hline  & & **MS** & **EcoliA** & **Saur** & **Calbi** & **EcoliESA** & **SaurESA** & **AB\_r** \\  & & **(\(\upg\)/mL)** & **(\(\upg\)/mL)** & **(\(\upg\)/mL)** & **(\(\upg\)/mL)** & **(\(\upg\)/mL)** & **(\(\upg\)/mL)** \\ \hline \multirow{6}{*}{**Condida**} & & EF & 4.57 \(\pm\) 0.29 \({}^{\text{a}}\) & 0.79 \(\pm\) 0.11 \({}^{\text{a}}\) & 8.37 \(\pm\) 0.50 \({}^{\text{a}}\) & 9.30 \(\pm\) 0.34 \({}^{\text{a}}\) & 2.63 \(\pm\) 0.24 \({}^{\text{a}}\) & 15.00 \(\pm\) 1.08 \({}^{\text{a}}\) \\  & & MF & 4.96 \(\pm\) 0.35 \({}^{\text{c}}\) & 0.89 \(\pm\) 0.09 \({}^{\text{a}}\) & 8.90 \(\pm\) 0.55 \({}^{\text{a}}\) & 10.22 \(\pm\) 0.61 \({}^{\text{a}}\) & 2.85 \(\pm\) 0.1 \({}^{\text{a}}\) & 19.16 \(\pm\) 1.57 \({}^{\text{b}}\) \\  & & LF & 5.67 \(\pm\) 0.21 \({}^{\text{b}}\) & 1.21 \(\pm\) 0.12 \({}^{\text{b}}\) & 10.34 \(\pm\) 0.50 \({}^{\text{b}}\) & 11.19 \(\pm\) 0.79 \({}^{\text{a}}\) & 3.02 \(\pm\) 0.22 \({}^{\text{a}}\) & 19.89 \(\pm\) 3.48 \({}^{\text{b}}\) \\  & & EF & 6.00 \(\pm\) 0.26 \({}^{\text{b}}\) & 0.87 \(\pm\) 0.08 \({}^{\text{a}}\) & 10.53 \(\pm\) 0.58 \({}^{\text{b}}\) & 9.72 \(\pm\) 1.15 \({}^{\text{a}}\) & 3.21 \(\pm\) 0.24 \({}^{\text{b}}\) & 19.43 \(\pm\) 1.43 \({}^{\text{b}}\) \\  & & MF & 7.28 \(\pm\) 0.43 \({}^{\text{a}}\) & 1.32 \(\pm\) 0.16 \({}^{\text{b}}\) & 11.48 \(\pm\) 0.74 \({}^{\text{b}}\) & 11.47 \(\pm\) 1.51 \({}^{\text{b}}\) & 3.83 \(\pm\) 0.25 \({}^{\text{c}}\) & 22.59 \(\pm\) 1.68 \({}^{\text{b}}\) \\  & & LF & 8.46 \(\pm\) 0.29 \({}^{\text{a}}\) & 1.57 \(\pm\) 0.21 \({}^{\text{c}}\) & 13.40 \(\pm\) 0.71 \({}^{\text{c}}\) & 13.77 \(\pm\) 1.00 \({}^{\text{c}}\) & 4.05 \(\pm\) 0.24 \({}^{\text{c}}\) & 25.61 \(\pm\) 0.87 \({}^{\text{c}}\) \\  & & Gentamicin & Gentamicin & Anfortericin B & Gentamicin & Anfortericin B & Anfortericin B \\  & & (\(\upg\)/mL) & (\(\upg\)/mL) & (\(\upg\)/mL) & (\(\upg\)/mL) & (\(\upg\)/mL) & (\(\upg\)/mL) & (\(\upg\)/mL) \\  & & 6.16 \(\pm\) 0.08 & 1.11 \(\pm\) 0.04 & 10.50 \(\pm\) 0.005 & 10.95 \(\pm\) 0.21 & 3.27 \(\pm\) 0.08 & 20.20 \(\pm\) 0.22 \\ \hline \hline \end{tabular}
\end{table} 
Table 4: Antimicrobial bioactivity activity of the _A. dealbata_ flower extracts with different maturation stages.