###### Abstract  
The creation of scaffolds for cartilage tissue engineering has faced significant challenges in developing constructs that can provide sufficient biomechanical support and offer suitable degradation characteristics. Ideally, such tissue-engineering techniques necessitate the fabrication of scaffolds that mirror the mechanical characteristics of the articular cartilage while degrading safely without damaging the regenerating tissues. The aim of this study was to create porous, biomechanically comparable 3D-printed scaffolds made from Poly(L-lactide-co-glycolic) 85:15 and to assess their degradation at physiological conditions 37 \({}^{\circ}\)C in pH 7.4 phosphate-buffered saline (PBS) for up to 56 days. Furthermore, the effect of scaffold degradation on the cell viability and proliferation of human bone marrow mesenchymal stem cells (HBMSC) was evaluated in vitro. To assess the long-term degradation of the scaffolds, accelerated degradation tests were performed at an elevated temperature of 47 \({}^{\circ}\)C for 28 days. The results show that the fabricated scaffolds were porous with an interconnected architecture and had comparable biomechanical properties to native cartilage. The degradative changes indicated stable degradation at physiological conditions with no significant effect on the properties of the scaffold and biocompatibility of the scaffold to HBMSC. Furthermore, the accelerated degradation tests showed consistent degradation of the scaffolds even in the long term without the notable release of acidic byproducts. It is hoped that the fabrication and degradation characteristics of this scaffold will, in the future, translate into a potential medical device for cartilage tissue regeneration. poly(L-lactide-co-glycolic); accelerated; degradation; cartilage tissue engineering; bioresorbable 3  
(PGA), Polylactide (PLA), and their related copolymers like Polylactic-co-glycolic acid (PLGA) have been employed in the past [8] with PLA found in the L enantiomer form, namely poly(L-lactide) (PLLA), a popular choice for biomedical applications. Since the use of copolymers enables greater control of mechanical properties, as well as degradation rates, the copolymerisation of PLLA and PGA, forming Poly(L-lactide-co-glycolic) (PLLGA) is an excellent material for load-bearing applications due to its superior mechanical strength and semi-crystalline structure [9]. The different variables that can affect the degradation rate of PLGA are (i) molecular weight and (ii) the ratio of Lactic acid to Glycolic acid [10]. Due to its reasonable degradation (\(\sim\)6-12 months) and comparable biomechanical properties (compressive modulus 1-2 MPa) to the native cartilage (compressive modulus 0.45-0.8 MPa), PLGA with high Lactic acid-to-Glycolic acid ratio and ester end cap can make an effective scaffold for cartilage regeneration [11; 12]. It is for this reason that PLLGA 85:15 has been selected as the material for this study that has not been widely evaluated in the past as a scaffold for cartilage tissue engineering applications. The utilisation of a high Lactic acid-to-Glycolic acid ratio like PLLGA 85:15 is hypothesised to provide stable degradation and to support biocompatibility in the host. PLGA scaffolds to date have mostly been fabricated using manufacturing methods that allow limited control over the architecture and porosity of the scaffolds, which can be a concern for reproducibility, mechanical properties, and cartilage regeneration [9; 10; 13; 14]. A scaffold with a porous, interconnected structure is a prerequisite for tissue regeneration because it enables the efficient mass transfer of oxygen and nutrients for infiltrating cells and a suitable surface area for cell proliferation [15; 16]. 3D printing offers previously unheard-of versatility, with exact control over pore characteristics [17].