## 4 Conclusions  
As shown, the seeds of some unexplored taxa belonging to the _Ribes_ genus constitute potentially raw sources of healthy phenolic compound-rich seed oils, in addition to their already known GLA-rich FA profiles. Among the different taxa analyzed here, we highlight _R. nigrum_ cultivars due to the diversity of compounds they show, especially _Ribes_ 'Algo' Yakutskaya and _R. nigrum_ 'Koksa'. The compounds that were identified in all _Ribes_ samples were ferulic and 4-hydroxybenzoic acids, while some compounds were restricted to a few taxa. It was not possible to establish a correlation between the presence of phenolic compounds and taxonomic rank and, probably, environmental factors were more decisive for compound occurrence than any genetic proximity. This highlights the antiproliferative activity of some seed extracts against HT-29 cells. Cell growth inhibition was strongly affected by _R. nigrum_ 'Koksa' and _Ribes_ 'Erkeeni', which show very low \(\text{GI}_{50}\) values and contain most identified phenolics. Future research on this subject should be carried out to elucidate the composition of other components of the unsaponifiable of these oils, such as sterols and tools, and it is recommended to obtain _Ribes_ oils exclusively by cold pressing so that they can be enriched in the healthy components contained in the unsaponifiable fraction. Other actions should be carried out to deepen the knowledge of the quantification of the detected phenolics and their individual or combined actions against various cancer cell lines. Furthermore, research devoted to unraveling the molecular mechanisms underlying the antitumor activity displayed by each of the detected phenolics on colorectal cancer cells will be welcomed.  
Figure 3: MTT assay. \(\text{GI}_{50}\) after HT-29 cell exposure for 48 and 72 h to seed extracts, as well as ferulic acid and doxorubicin (positive control). The \(\text{GI}_{50}\) value is detailed over the columns, and the SI for 72 h exposed cells to seed extracts is shown in parentheses. Data represent the mean of three complete independent experiments \(\pm\) SD (error bars). In a bar, means followed by different lower-case letters (for 48 h treatment) and capital letters (for 72 h) are significantly different at \(p<0.05\).  
**Author Contributions:** Conceptualization, S.L., I.R.-G. and J.L.G.-G.; Methodology, S.L., R.L.-R. and J.L.G.-G.; Software, S.L., R.L.-R., I.R.-G. and J.L.G.-G.; Validation, S.L., R.L.-R., A.M.G.-C., I.R.-G., S.Y. and J.L.G.-G.; Formal Analysis, S.L., R.L.-R., A.M.G.-C., I.R.-G., S.Y. and J.L.G.-G.; Investigation, S.L., R.L.-R. and J.L.G.-G.; Resources, R.L.-R. and J.L.G.-G.; Data Curation, S.L., R.L.-R., A.M.G.-C., I.R.-G., S.Y. and J.L.G.-G.; Writing--Original Draft Preparation, S.L. and J.L.G.-G.; Writing--Review & Editing, S.L., I.R.-G. and J.L.G.-G.; Visualization, S.L., R.L.-R., A.M.G.-C., I.R.-G., S.Y. and J.L.G.-G.; Supervision, J.L.G.-G., Project Administration, R.L.-R. and J.L.G.-G.; Funding Acquisition, R.L.-R. and J.L.G.-G. All authors have read and agreed to the published version of the manuscript.  
The authors acknowledge financial support from Junta de Andalucia (Project P20_00806), University of Almeria (P_LANZ_2023/003), Campus de Excelencia Internacional Agroalimentario (ceiA3), and Centro de Investigacion en Agrosistemas Intensivos Mediterraneos y biotecnologia Agroalimentaria (CIAMBITAL), and the State Tasks 'FMRS-2022-0023-122031400260-7'.  
**Informed Consent Statement:** Not applicable.  
**Data Availability Statement:** The original contributions presented in the study are included in the article, and further inquiries can be directed to the corresponding author.  
**Acknowledgments:** The authors acknowledged the botanical gardens listed in Table 1 for providing plant material.  
**Conflicts of Interest:** The sponsors had no role in the design, execution, interpretation, or writing of the study.