## 3 Results
### Ocular Symptoms Three Months after LASIK
\begin{table}
\begin{tabular}{c c c c} \hline \hline  & **Pregabalin** & **Control** & \(p\)-Value** \\ \hline Number & 21 & 22 & \\ \hline Demographics & & & \\ \hline Age, years, mean (SD) & \(37.8\) (\(9.8\)) & \(33.0\) (\(0.6\)) & \(0.12\) \\ \hline Female, \(n\) (\%) & 14 (67\%) & 8 (60\%) & 0.047 \\ \hline Race, white, \(n\) (\%) & 18 (86\%) & 18 (82\%) & 0.92 \\ \hline Hispanic, \(n\) (\%) & 11 (52\%) & 11 (50\%) & 0.88 \\ \hline Surgical information, mean (SD) & & & \\ \hline Spherical equivalent of treatment, D* & \(-3.48\) (\(3.25\)) & \(-3.95\) (\(1.79\)) & 0.56 \\ \hline Flap depth, microns, mean (SD) & 117 (21) & 109 (30) & 0.34 \\ \hline Eye co-modorbidities, \(n\) (\%) & & & \\ \hline Self-reported eye allergies & 1 (5\%) & 2 (9\%) & 1.0 \\ \hline Contact lens wear prior to surgery & 16 (70\%) & 13 (99\%) & 0.23 \\ \hline Artificial tears use prior to surgery & 4 (19\%) & 5 (23\%) & 1.0 \\ \hline Eye symptoms & & & \\ \hline DEQS, mean (SD), range 0-22 & 5.5 (3.6) & 4.3 (4.5) & 0.34 \\ \hline DEQS, mild symptoms \(>\)26, \(n\) (\%) & 10 (48\%) & 9 (41\%) & 0.66 \\ \hline DEQS, severe symptoms \(>\)12, \(n\) (\%) & 2 (10\%) & 2 (10\%) & 0.96 \\ \hline OSDI, mean (SD), range 0-100 & 11.9 (14.3) & 9.0 (13.6) & 0.50 \\ \hline Ocular pain, worst over one week recall, mean (SD), range 0-10 & 0.48 (0.75) & 0.64 (0.75) & 0.61 \\ \hline \hline \multicolumn{4}{l}{Scalar pain, average over one week recall, mean (SD), range 0-10} & 0.38 (0.67) & 0.36 (0.66) & 0.93 \\ \hline \multicolumn{4}{l}{\(\$\$\)-MPQ sensory, mean (SD), range 0-33} & 0.90 (1.84) & 0.09 (0.29) & 0.06 \\ \hline \multicolumn{4}{l}{\(\$\$\)-MPQ affective, mean (SD), range 0-12} & 0.43 (0.68) & 0.23 (0.61) & 0.31 \\ \hline Intensity of burning over one day recall, mean (SD), range 0-10 & 0.10 (0.30) & 0.27 (0.63) & 0.25 \\ \hline Intensity of wind sensitivity one day recall, mean (SD), range 0-10 & 0.48 (0.68) & 0.36 (1.09) & 0.69 \\ \hline Intensity of light sensitivity one day recall, mean (SD), range 0-100 & 0.86 (1.42) & 0.68 (1.81) & 0.73 \\ \hline NTSI-Eye total, mean (SD), range 0-100 & 2.52 (3.46) & 2.36 (4.87) & 0.90 \\ \hline Eye signs * & & & \\ \hline Any eyelid laxity, \(n\) (\%) & 3 (14\%) & 2 (9\%) & 0.66 \\ \hline Inflammatory score \(\geq\)2, \(n\) (\%) & 4 (19\%) & 3 (14\%) & 0.63 \\ \hline Inflammatory positive, \(n\) (\%) & 11 (52\%) & 15 (68\%) & 0.07 \\ \hline TBUT, seconds, mean (SD) & 10.9 (7.3) & 9.1 (6.2) & 0.67 \\ \hline Conjunctivochallas, \(n\) (\%) & 12 (5\%)* & 16 (73\%) & 0.28 \\ \hline General staining, mean (SD) & 22 (2.5) & 2.6 (2.7) & 0.66 \\ \hline Anterior tuberharitis, mean (SD) & 0.95 (0.80) & 1.00 (0.82) & 0.85 \\ \hline Eyeld vascularity, mean (SD) & 1.00 (0.95) & 0.77 (0.81) & 0.40 \\ \hline Meibomian plugging, mean (SD) & 1.33 (0.91) & 1.41 (0.91) & 0.79 \\ \hline Meibomian gland drop, mean (SD) & 1.24 (1.04) & 0.91 (0.75) & 0.24 \\ \hline Schirmers test, mm wetting, mean (SD) & 12.8 (7.4) & 17.0 (9.0) & 0.10 \\ \hline Meibomian quality, mean (SD) & 1.95 (1.32) & 1.59 (1.18) & 0.35 \\ \hline Conjunctiviral papillae, zmidl, \(n\) (\%) & 15 (71\%) & 14 (64\%) & 0.86 \\ \hline Co-modorbidities & & & \\ \hline Average daily screen time, hours, mean (SD) & 8.7 (4.1) & 7.9 (3.0) & 0.44 \\ \hline Depression via Scl-90, mean (SD), range 0-4 & 0.32 (0.33) & 0.28 (0.64) & 0.82 \\ \hline Anxiety via Scl-90, mean (SD), range 0-4 & 0.24 (0.29) & 0.13 (0.24) & 0.16 \\ \hline Carpet at home, \(n\) (\%) & 5 (24\%) & 4 (18\%) & 0.65 \\ \hline Non-contact allergies, \(n\) (\%) & 5 (24\%) & 5 (23\%) & 0.93 \\ \hline Chronic pain in any area, \(n\) (\%) & 5 (24\%) & 4 (18\%) & 0.22 \\ \hline Headache (including migraine), \(n\) (\%) & 3 (14\%) & 2 (9\%) & 0.66 \\ \hline No of chronic pain conditions (headache, low back pain, sciatic, & & \\ irritable bowel), mean (SD) & 0.52 (1.33) & 0.23 (0.61) & 0.35 \\ \hline Average non-ocular pain intensity, one week recall, mean (SD) & 0.71 (1.62) & 0.50 (1.19) & 0.62 \\ \hline \hline \end{tabular} SD = Standard deviation, D = dipeters, DEQS = Dry Eye Questionnaire 5, OSDI = Ocular Surface Disease Index, sf-MPQ = short form McGill Pain Questionnaire, NPSI-Eye = Neuropathatic Pain Symptom Inventory modified for the eye, TBUT = tear break up time, SCL = Symptom Checklist,* Unless indicated, value from more severely affected eye used in analysis.  
\end{table}