## 4 Discussion
\begin{table}
\begin{tabular}{c c c c c c} \hline \hline \multirow{2}{*}{**Unvaccinated**} & \multicolumn{4}{c}{**Vaccinated**} \\ \cline{2-6}  & **1** & **2–3** & \(\geq\)**4** & \(p\) **for Trend** \\ \cline{2-6}  & **Adjusted HR** & **Adjusted HR** & **Adjusted HR** & **Adjusted HR** & **(95\% CI)** & \\ \cline{2-6}  & **(95\% CI)** & **(95\% CI)** & **(95\% CI)** & **(95\% CI)** & \\ \hline Main model \({}^{\dagger}\) & 1.00 & 0.84 (0.79, 0.89) *** & 0.67 (0.63, 0.71) *** & 0.39 (0.37, 0.41) *** & \(<\)0.001 \\ Subgroup effects & & & & & \\ Age, years & & & & & \\
55–64 & 1.00 & 0.64 (0.57, 0.71) *** & 0.51 (0.45, 0.57) *** & 0.36 (0.31, 0.41) *** & \(<\)0.001 \\ \(\geq\)65 & 1.00 & 0.94 (0.87, 1.02) & 0.72 (0.67, 0.78) *** & 0.39 (0.36, 0.41) *** & \(<\)0.001 \\ Sex & & & & & \\ Female & 1.00 & 0.87 (0.79, 0.95) *** & 0.70 (0.64, 0.76) *** & 0.42 (0.38, 0.45) *** & \(<\)0.001 \\ Male & 1.00 & 0.82 (0.76, 0.89) *** & 0.64 (0.59, 0.69) *** & 0.36 (0.33, 0.40) *** & \(<\)0.001 \\ Diabetes & & & & & \\ No & 1.00 & 0.84 (0.78, 0.90) *** & 0.67 (0.62, 0.71) *** & 0.39 (0.37, 0.42) *** & \(<\)0.001 \\ Yes & 1.00 & 0.84 (0.75, 0.95) ** & 0.67 (0.59, 0.75) *** & 0.38 (0.33, 0.43) *** & \(<\)0.001 \\ Dyslipidemia & & & & & \\ No & 1.00 & 0.85 (0.80, 0.91) *** & 0.67 (0.63, 0.72) *** & 0.39 (0.37, 0.42) *** & \(<\)0.001 \\ Yes & 1.00 & 0.78 (0.68, 0.89) *** & 0.65 (0.57, 0.74) *** & 0.37 (0.33, 0.43) *** & \(<\)0.001 \\ AF & & & & & \\ No & 1.00 & 0.84 (0.79, 0.90) *** & 0.67 (0.63, 0.71) *** & 0.38 (0.36, 0.41) *** & \(<\)0.001 \\ Yes & 1.00 & 0.82 (0.68, 0.98) * & 0.66 (0.55, 0.78) *** & 0.42 (0.35, 0.49) *** & \(<\)0.001 \\ Antihypertensive & & & & & \\ No (<28 days) & 1.00 & 0.84 (0.78, 0.90) *** & 0.65 (0.61, 0.70) *** & 0.36 (0.34, 0.39) *** & \(<\)0.001 \\ Yes (\(\geq\)28 days) & 1.00 & 0.86 (0.76, 0.97) * & 0.72 (0.65, 0.81) *** & 0.46 (0.41, 0.51) *** & \(<\)0.001 \\ Diuretics & & & & & \\ No (<28 days) & 1.00 & 0.88 (0.80, 0.98) * & 0.64 (0.57, 0.71) *** & 0.34 (0.31, 0.39) *** & \(<\)0.001 \\ Yes (\(\geq\)28 days) & 1.00 & 0.83 (0.76, 0.89) *** & 0.68 (0.64, 0.73) *** & 0.40 (0.38, 0.43) *** & \(<\)0.001 \\ Beta blocking agents & & & & & \\ No (<28 days) & 1.00 & 0.81 (0.74, 0.90) *** & 0.64 (0.58, 0.71) *** & 0.35 (0.32, 0.39) *** & \(<\)0.001 \\ Yes (\(\geq\)28 days) & 1.00 & 0.85 (0.79, 0.92) *** & 0.68 (0.63, 0.74) *** & 0.41 (0.38, 0.44) *** & \(<\)0.001 \\ Calcium channel blockers & & & & & \\ No (<28 days) & 1.00 & 0.83 (0.73, 0.96) * & 0.62 (0.54, 0.72) *** & 0.34 (0.29, 0.41) *** & \(<\)0.001 \\ Yes (\(\geq\)28 days) & 1.00 & 0.84 (0.79, 0.90) *** & 0.68 (0.63, 0.72) *** & 0.40 (0.37, 0.42) *** & \(<\)0.001 \\ RAA & & & & & \\ No (<28 days) & 1.00 & 0.85 (0.76, 0.96) ** & 0.63 (0.56, 0.71) *** & 0.33 (0.29, 0.38) *** & \(<\)0.001 \\ Yes (\(\geq\)28 days) & 1.00 & 0.84 (0.78, 0.90) *** & 0.68 (0.64, 0.73) *** & 0.41 (0.38, 0.44) *** & \(<\)0.001 \\ Statin drugs & & & & & \\ <28 days & 1.00 & 0.86 (0.80, 0.93) *** & 0.69 (0.64, 0.74) *** & 0.38 (0.35, 0.41) *** & \(<\)0.001 \\
28–365 days & 1.00 & 0.74 (0.65, 0.85) *** & 0.60 (0.52, 0.68) *** & 0.38 (0.33, 0.44) *** & \(<\)0.001 \\ >365 days & 1.00 & 0.86 (0.74, 1.00) * & 0.67 (0.58, 0.77) *** & 0.45 (0.39, 0.51) *** & \(<\)0.001 \\ Metformin drug & & & & \\ <28 days & 1.00 & 0.84 (0.78, 0.90) *** & 0.67 (0.63, 0.72) *** & 0.38 (0.35, 0.41) *** & \(<\)0.001 \\
28–365 days & 1.00 & 0.81 (0.66, 0.99) * & 0.60 (0.49, 0.73) *** & 0.37 (0.30, 0.46) *** & \(<\)0.001 \\ >365 days & 1.00 & 0.86 (0.75, 0.99) * & 0.70 (0.61, 0.80) *** & 0.44 (0.39, 0.51) *** & \(<\)0.001 \\ Aspirin drug & & & & & \\ <28 days & 1.00 & 0.86 (0.77, 0.96) ** & 0.69 (0.61, 0.77) *** & 0.35 (0.31, 0.40) *** & \(<\)0.001 \\
28–365 days & 1.00 & 0.83 (0.74, 0.92) *** & 0.60 (0.54, 0.66) *** & 0.36 (0.33, 0.41) *** & \(<\)0.001 \\ >365 days & 1.00 & 0.86 (0.78, 0.96) ** & 0.73 (0.66, 0.80) *** & 0.44 (0.40, 0.48) *** & \(<\)0.001 \\ \hline \hline \end{tabular}  
*: \(p<0.05\) **: \(p<0.01\) ***: \(p<0.001\) HR: hazard ratio. \({}^{\dagger}\) Main model is adjusted for age, sex, Charlson comorbidity index, diabetes, dyslipidemia, AF, antihypertensives, diuretics, beta blocking agents, calcium channel blockers, RAA, statin, metformin, aspirin, level of urbanization and monthly income in propensity score.  
\end{table}