## 3 Results  
### Effectiveness of Tested Substances against MRSA Standard Strain  
Based on the results, it was confirmed that the _S. aureus_ ATCC 43300 strain was susceptible to four out of five tested commercial antiseptics. Among all substances, CITROclorex 2% and Microdacyn 60 Wound Care exhibited the best and the weakest antibacterial properties, respectively. Furthermore, it was observed that three out of four antiseptics which were active against the reference strain had a bacteriostatic effect. It was also noted that the _S. aureus_ ATCC 43300 strain was susceptible to five out of ten natural products. Of all the compounds, famesol exhibited the best antistaphylococcal properties. Five out of ten tested natural agents (eucalypt, limonene, linalyl acetate, (-)-menthone and _trans_-anethole) showed no antimicrobial properties (MIC > 50.0%). Furthermore, four out of five active substances of natural origin demonstrated a bactericidal effect against the reference strain of _S. aureus_. Detailed data regarding MIC, MBC, the MBC/MIC ratio and the effectiveness of the tested substances against the _S. aureus_ ATCC 43300 strain are listed in Table 1.  
Analysis of Interaction of Commercial Antiseptics with Natural Products against MRSA Standard Strain  
The obtained results showed that four out of five Braunol-natural product combinations decreased the MIC level of the commercial antiseptic and natural compounds, \begin{table}
\begin{tabular}{l c c c c} \hline \hline
**Substance** & **MIC (\%)** & **MBC (\%)** & **MBC/MIC Ratio** & **Effectiveness** \\ \hline Commercial antiseptics & & & & \\  Braunol & 6.25 \(\pm\) 0.00 & 12.5 \(\pm\) 0.00 & 2 & BB \\  CITROclorex 2\% & 0.01 \(\pm\) 0.00 & 0.10 \(\pm\) 0.00 & 8 & BS \\  Octenisept & 0.20 \(\pm\) 0.00 & 1.56 \(\pm\) 0.00 & 8 & BS \\  Prontooderm Solution & 0.20 \(\pm\) 0.00 & 1.17 \(\pm\) 0.55 & 6 & BS \\  Microdacyn 60 Wound Care & \textgreater{}50.0 & \textgreater{}50.0 & - & - \\ \hline Natural products & & & & \\ \(\beta\)-citronellol & 6.25 \(\pm\) 0.00 & 6.25 \(\pm\) 0.00 & 1 & BB \\  Eugenol & 3.13 \(\pm\) 0.00 & 3.13 \(\pm\) 0.00 & 1 & BB \\  Eucalyptus & \textgreater{}50.0 & \textgreater{}50.0 & - & - \\  Farnesol & 0.10 \(\pm\) 0.00 & 0.78 \(\pm\) 0.00 & 8 & BS \\  Geraniol & 3.13 \(\pm\) 0.00 & 3.13 \(\pm\) 0.00 & 1 & BB \\  Carvacrol & 0.78 \(\pm\) 0.00 & 0.78 \(\pm\) 0.00 & 1 & BB \\  Limonene & \textgreater{}50.0 & \textgreater{}50.0 & - & - \\ (-)-Menthone & \textgreater{}50.0 & \textgreater{}50.0 & - & - \\  Linalyl acetate & \textgreater{}50.0 & \textgreater{}50.0 & - & - \\ _trans_-Anethole & \textgreater{}50.0 & \textgreater{}50.0 & - & - \\ \hline \hline \end{tabular} BB— bactericidal activity; BS— bacteriostatic activity.  
\end{table} 
Table 1: Analysis of results of the minimum inhibitory concentration (MIC), the minimum bactericidal concentration (MBC), the MBC/MIC ratio and the effectiveness of tested substances against the _Staphylococcus aureus_ (ATCC 43300) strain. respectively. This was most noticeable in the Braumol-\(\beta\)-citronellol combination, for which a statistically significant decrease in the MIC value of the antiseptic (8-fold) and natural constituent (16-fold) was observed. Four out of five CITROclorex 2%-natural agent combinations contributed to a 2- or 5-fold increase in the MIC value of the antiseptic. Nevertheless, these combinations variably influenced the MIC value of natural ingredients, for which increased (\(n=2/5\)) and decreased (\(n=3/5\)) antibacterial activity was recorded, respectively. For three out of five Octenisept-natural agent combinations, a 2-fold increase in the MIC value of Octenisept in combination with eugenol, farnesol and carvacrol was found. Interestingly, in most cases (\(n=4/5\)) of interactions, phytochemicals were characterized by higher antibacterial activity. This was most visible in the Octenisept-\(\beta\)-citronellol combination, where a statistically significant reduction (16-fold) in the MIC value of the natural ingredient against the analyzed strain was noted.