## 3 Materials and Methods
#### Synthesis of the Starting Substrates
\({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\) = 13.22 (brs, 1H), 7.79 (d, \(J\) = 7.6 Hz, 1H), 7.72-7.63 (m, 4H), 7.45-7.41 (m, 1H), 7.37-7.33 (m, 1H), and 7.28-7.24 (m, 2H) ppm; \({}^{13}\)C[\({}^{1}\)H] NMR (100 MHz, DMSO-\(d_{6}\)) \(\delta\) = 154.4, 147.2, 1431.1, 127.9, 125.7, 123.6, 122.6 (brs), 121.9, 111.3, and 106.1 ppm. _2-(Futman-2-yl)-1H-benzo[d]imidazole_ (**3a**) [71]. A yield of 0.182 g (76%), 7 h, grey solid. Mp. = 235-237 \({}^{\circ}\)C (EtOAc, lit. [71] 230-232 \({}^{\circ}\)C). \({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) = 12.88 (br.s, 1H), 7.93-7.92 (m, 1H), 7.58-7.54 (m, 2H), 7.22-7.18 (m, 3H), and 6.73-6.71 (m, 1H) ppm; \({}^{13}\)C[\({}^{1}\)H] NMR (100 MHz, DMSO-\(d_{6}\)) \(\delta\) = 145.5, 144.5, 143.5, 138.9 (brs), 122.1, 115.1 (brs), 112.2, and 110.3 ppm. _2-(Thiophen-2-yl)-1H-benzo[d]imidazole_ (**3a**) [72]. A yield of 0.247 g (95%), 6 h, light-beige solid. Mp. = 308-309 \({}^{\circ}\)C (DMAC/H\({}_{2}\)O, lit. [72] 312-313 \({}^{\circ}\)C). \({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\) = 12.91 (br.s, 1H), 7.84-7.83 (m, 1H), 7.72-7.71 (m, 1H), 7.58-7.54 (m, 2H), and 7.24-7.18 (m, 3H) ppm; \({}^{13}\)C[\({}^{1}\)H] NMR (100 MHz, DMSO-\(d_{6}\)) \(\delta\) = 146.9, 138.9 (brs), 133.6, 128.6, 128.1, 126.6, 122.1, and 114.6 (brs) ppm. _2-(1-Methyl-1H-pyrrol-2-yl)-1H-benzo[d]imidazole_ (**3 av**) [73]. A yield of 0.177 g (69%), 12 h, light-beige solid. Mp. = 231-232 \({}^{\circ}\)C, decomposition (EtOH, lit. [74] 231-232(m, 2H), 7.98-7.95 (m, 2H), 7.61-7.56 (m, 4H), 7.43-7.39 (m, 1H), 7.30-7.25 (m, 2H), and 7.23-7.19 (m, 2H) ppm; \({}^{13}\)C[\({}^{1}\)H] NMR (100 MHz, DMSO-\(d_{6}\)) \(\delta\) = 162.2 (d, \(J_{\rm CF}\) = 243.0 Hz), 149.4, 145.4, 138.9, 130.3 (d, \(J_{\rm CF}\) = 10.0 Hz), 130.29, 129.6, 128.8 (d, \(J_{\rm CF}\) = 3.0 Hz), 126.9, 121.8, 118.5, 115.0 (d, \(J_{\rm CF}\) = 21.0 Hz), and 112.6 ppm. _2-Cyclohexyl-1H-benzo[d]imidazole_ (**3 ay**) [76]. A yield of 0.169 g (65%), 6 h, beige solid. Mp. = 218-219 \({}^{\circ}\)C, decomposition (acetone/EtOAc, lit. [76] 222-224 \({}^{\circ}\)C). \({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\) = 7.48-7.44 (m, 2H), 7.13-7.08 (m, 2H), 2.88-2.81 (m, 1H), 2.04-2.00 (m, 2H), 1.83-1.57 (m, 5H), and 1.45-1.21 (m, 3H) ppm; \({}^{13}\)C[\({}^{1}\)H] NMR (100 MHz, DMSO-\(d_{6}\)) \(\delta\) = 158.7, 138.4 (br.s), 120.9, 114.3 (br.s), 37.6, 31.1, 25.5, and 25.4 ppm. _2-(1H-Indol-3-yl)benzo[d]thiazol_ (**3 az**) [77]. A yield of 0.284 g (87%), 16 h, beige solid. Mp. = 170-172 \({}^{\circ}\)C (EtOH, lit. [77] 171-172 \({}^{\circ}\)C). \({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\) = 11.90 (br.s, 1H), 8.42-8.38 (m, 1H), 8.25 (d, \(J\) = 2.8 Hz, 1H), 8.03 (d, \(J\) = 8.0 Hz, 1H), 7.98 (d, \(J\) = 8.0 Hz, 1H), 7.56-7.53 (m, 1H), 7.50-7.46 (m, 1H), 7.37-7.33 (m, 1H), 7.29-7.25 (m, 2H) ppm; \({}^{13}\)C[\({}^{1}\)H] NMR (100 MHz, DMSO-\(d_{6}\)) \(\delta\) = 162.7, 136.7, 133.0, 128.7, 126.0, 124.5, 124.1, 122.6, 121.6, 121.5, 121.0, 120.6, 112.2, and 110.4 ppm. _2-(Thiophen-2-yl)benzo[d]thiazol_ (**3 ba**) [78]. A yield of 0.272 g (96%), 2 h, beige needles. Mp. = 97-99 \({}^{\circ}\)C (EtOH, lit. [78] 99-100 \({}^{\circ}\)C). \({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\) = 8.10-8.08 (m, 1H), 8.01-7.98 (m, 1H), 7.86-7.82 (m, 2H), 7.54-7.50 (m, 1H), 7.46-7.42 (m, 1H), and 7.25-7.23 (m, 1H) ppm; \({}^{13}\)C[\({}^{1}\)H] NMR (100 MHz, DMSO-\(d_{6}\)) \(\delta\) = 160.7, 153.0, 136.3, 134.1, 130.6, 129.4, 128.6, 126.6, 125.4, 122.3, and 122.1 ppm. _2-(Furan-2-yl)benzo[d]thiazol_ (**3 bb**) [78]. A yield of 0.249 g (95%), 2 h, beige solid. Mp. = 105-107 \({}^{\circ}\)C (EtOH, lit. [78] 106-107 \({}^{\circ}\)C). \({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\) = 8.14-8.09 (m, 1H), 8.03-7.97 (m, 2H), 7.56-7.52 (m, 1H), 7.47-7.42 (m, 1H), 7.35-7.31 (m, 1H), and 6.79-6.76 (m, 1H) ppm; \({}^{13}\)C[\({}^{1}\)H] NMR (100 MHz, DMSO-\(d_{6}\)) \(\delta\) = 156.7, 153.2, 147.9, 146.0, 133.6, 126.6, 125.3, 122.6, 112.2, and 111.8 ppm.