A mechanistic study and review of volatile products from peroxidation of unsaturated fatty acids: An aid to understanding the origins of volatile organic compounds from the human body. J. Breath Res. **2020**, _14_, 34001. 16.22. Fabric Phase Sorptive Extraction Coupled to Porous Graphitized Carbon Liquid Chromatography for the Quantitation of Parabens in Human Breast Milk A. Parla 1,*, I. Balatsouka 1, G. Mavrogeorgos 2, A. Kabir 3, V. Samanidou 4, K. G. Furton 3, D. Gennimata 5, I. Vinkovic Vrcek 6 and I. Panderi 1,*  
1 Laboratory of Pharmaceutical Analysis, Division of Pharmaceutical Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece  
2 P.&A. Kyriakou Children's Hospital, 15771 Athens, Greece  
3 Department of Chemistry and Biochemistry, International Forensic Research Institute, Miami, FL 33199, USA  
4 Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece  
5 General Hospital \"Korgialenio-Benakio National Red Cross\", Eithrou Stavrou 1, 11526 Athens, Greece  
6 Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, 10000 Zagreb, Croatia  
* Correspondence: anthiparla@hotmail.com (A.P. ); irenepanderi@gmail.com (I.P.) Human breast milk is the optimum source of nutrition during the first six months of life with several health and social benefits. Drug treatment during breast feeding raises several issues including the risk of exposure to drugs and chemicals passing through the breast milk to the infant. Milk is slightly more acidic than human plasma and contains significantly more lipids and fewer proteins. Thus, drugs and chemicals with low molecular weight, low plasma protein binding, and high lipophilicity tend to concentrate more into the breast milk [1,2]. Parabens have been widely employed as preservatives since the 1920s for extending the shelf life of foodstuffs, medicines, and daily care products. Given the fact that there are some legitimate concerns related to their potential multiple endocrine disrupting properties, the development of novel bioanalytical methods for their biomonitoring is crucial. In recent years, the development of novel sample preparation procedures following the philosophy of Green Analytical Chemistry is a matter of growing interest among the analytical and bioanalytical scientists. To this purpose, we thought that it would be of interest to develop a method for the quantitation of parabens in human breast milk samples using a novel, eco-friendly, and efficient fabric phase sorptive extraction (FPSE) technique. In this work a fabric phase sorptive extraction-high performance liquid chromatography method (FPSE-HPLC) has been developed and validated for the quantification of parabens in human breast milk. This technique uses a natural or synthetic fabric membrane as a substrate that is chemically coated in the form of a very thin but spongy coating of sol-gel organic-inorganic hybrid sorbent. In this study, a sol-gel Carbowax(r) 20M coated FPSE membrane was used for sample preparation of the human breast milk samples [3]. Chromatographic separation was performed on a porous graphitized carbon analytical column which allowed the elution of the analytes within 10 min. The assay was linear over a concentration range of 20 to 500 ng mL\({}^{-1}\) for all the analytes, and it was applied to the analysis of parabens in real samples. ## References  
* Kiriazopoulos et al. 2017 Kiriazopoulos, E.; Zaharaki, S.; Vonaparti, A.; Vourna, P.; Panteri-Petratou, E.; Gennimata, D.; Lombardo, K.; Panderi, I. Quantification of three beta-lactam antibiotics in breast milk and human plasma by hydrophilic interaction liquid chromatography/ positive-ion electrospray ionization mass spectrometry. _Drug Test. Anal._**2017**, \(9\), 1062-1072. * Geballa-Koukoula et al.