## 1 Introduction  
There is an ever-growing need for research into new and innovative food sources, considering the expected large population increase and the necessity of reducing the ecological problems related to intensive food production [1]. The importance of this focus has also been highlighted in the United Nations 2030 Agenda, whose goals include zero hunger, good health and well-being, responsible consumption and production, climate action, and life on land [2]. In this context, edible insects represent an important potential food source capable of satisfying both sustainability and nutritional demands. Several sustainability advantages have been related to edible insect production, such as low water consumption, with an average expenditure of 1 L/Kg of insect proteins respect to 1.500 L/Kg of cattle proteins, lower feed consumption per Kg of obtained proteins, the generation of less greenhouse gases and ammonia, and the need for smaller spaces for farming [3, 4]. At the same time, edible insects are a good source of many essential nutrients such as proteins, fatty acids, minerals, and, in some cases, vitamins [5]. Entomology is a common practice in several cultures such as in Latin America, Asia, and Africa, with beetles, caterpillars, bees, wasps, and ants being the most-consumed insects [6]. Conversely, in Europe, the use of edible insects as food represents a niche practice. Nevertheless, in recent years, the environmental and nutritional advantages of edible insects have encouraged their gradual recognition as novel foods. Among them, _Acheta domesticus_ (house cricket) represents the last edible insect added to the official European list of novel foods, in frozen, dried and powder forms, through the Commission Implementing Regulation (EU) 2022/188 of 10 February 2022 [7]. To date, its chemical investigations reported in the literature have been focused on specific classes of compounds determined using appropriate targeted methodologies. The amino acid profile of cricket powder [8; 9; 10] as well as the fatty acid contents of cricket extracts [8; 9; 10; 11; 12] and their elemental profile [9; 12] have been reported. Moreover, phenolic acids and flavonoids have been measured in organic and commercial _A. domesticus_[13].  
Considering the increasing interest in and use of this edible insect, it is important to further develop the knowledge regarding its chemical composition. For this purpose, the simultaneous application of several advanced methodologies could be an effective strategy, as demonstrated in previous studies [14; 15].  
On the basis of these premises, in the present study, a spray-dried _A. domesticus_ powder was investigated, for the first time, through a multimethodological approach including both untargeted nuclear magnetic resonance (NMR) spectroscopy and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) and targeted gas chromatography-mass spectrometry (GC-MS) analyses to obtain a comprehensive chemical profile. In particular, the NMR and FT-ICR MS methodologies are recognized as the two main powerful untargeted approaches to achieve the metabolomic profiling of natural matrix extracts [16], since these techniques are able to identify, with a single analysis, several classes of compound present in a complex matrix. On the other hand, GC-MS is a targeted methodology useful for identifying and quantifying specific classes of compounds. Altogether, these complementary methodologies can be useful for obtaining the most co-exhaustive chemical profile of the product possible.