## 3 Results
### Prediction of plaque Progression
\begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Dependent Variable** & **Effect** & \multicolumn{2}{c}{**Univariate Linear Regression Analysis**} & \multicolumn{2}{c}{**Multivariate Linear Regression Analysis**} \\ \cline{3-6}  & & **Estimated Regression Coefficient (95\% CI)** & _p-Value_ & \multicolumn{2}{c}{**Estimated Regression Coefficient (95\% CI)**} & _p-Value_ \\ \hline \multirow{7}{*}{Plaque progression (at least 2 out of 3 of the criteria below)} & Age (years) & 0.006 (0.000 to 0.012) & 0.0429 & 0.011 (0.003 to 0.019) & 0.0067 \\ \cline{2-6}  & Triglycerides (mg/dl) & 0.001 (0.000 to 0.002) & 0.0417 & 0.001 (\(-\)0.001 to 0.002) & 0.2955 \\ \cline{2-6}  & CE\_18\_3 (\mu\)M) & 0.003 (0.001 to 0.005) & 0.0138 & 0.001 (\(-\)0.003 to 0.004) & 0.7102 \\ \cline{2-6}  & CE\_20\_3 (\mu\)M) & 0.008 (0.003 to 0.014) & 0.0043 & 0.006 (\(-\)0.006 to 0.018) & 0.3336 \\ \cline{2-6}  & CE\_20\_4 (\mu\)M) & 0.002 (0.000 to 0.003) & 0.0203 & 0.000 (\(-\)0.003 to 0.004) & 0.7980 \\ \cline{2-6}  & PC\_36\_0 (\mu\)M) & 0.009 (\(-\)0.001 to 0.018) & 0.0845 & - & - \\ \cline{2-6}  & PC\_36\_3 (\mu\)M) & 0.000 (\(-\)0.000 to 0.001) & 0.0756 & - & - \\ \cline{2-6}  & \multicolumn{2}{c}{TG\_54\_2\_TG_18\_1\_18\_0} & \multicolumn{2}{c}{18.0} & \multicolumn{2}{c}{(\(-\)0.000 to 0.004)} & 0.0872 & - & - \\ \cline{2-6}  & \multicolumn{2}{c}{(uM)} & 0.169 (0.017 to 0.321) & 0.0292 & \(-\)0.128 (\(-\)0.374 to 0.118) & 0.3046 \\ \cline{2-6}  & PS\_40\_6 (\mu\)M) & 0.325 (\(-\)0.054 to 0.705) & 0.0921 & - & - \\ \cline{2-6}  & SM\_42\_1 (\mu\)M) & 0.002 (\(-\)0.000 to 0.005) & 0.0892 & - & - \\ \cline{2-6}  & Baseline plaque & \(-\)0.012 (\(-\)0.013 to burden) & \(<\).0001 & \(-\)0.011 (\(-\)0.013 to \(-\)0.010) & \(<\)0.0001 \\ \cline{2-6}  & \multicolumn{2}{c}{(uM)} & 0.002 (\(-\)0.000 to 0.004) & 0.0872 & - & - \\ \cline{2-6}  & PS\_38\_6 (\mu\)M) & 0.169 (0.017 to 0.321) & 0.0292 & \(-\)0.128 (\(-\)0.374 to 0.118) & 0.3046 \\ \cline{2-6}  & PS\_40\_6 (\mu\)M) & 0.325 (\(-\)0.054 to 0.705) & 0.0921 & - & - \\ \cline{2-6}  & SM\_42\_1 (\mu\)M) & 0.002 (\(-\)0.000 to 0.005) & 0.0892 & - & - \\ \cline{2-6}  & Baseline plaque & \(-\)0.012 (\(-\)0.013 to burden) & \(<\).0001 & \(-\)0.011 (\(-\)0.013 to \(-\)0.010) & \(<\)0.0001 \\ \cline{2-6}  & burden & \(-\)0.011) & \(<\).0001 & \(-\)0.010) & \(<\)0.0001 \\ \cline{2-6}  & Minimum ESS (Pa) & \(-\)0.056 (\(-\)0.074 to \(-\)0.038) & \(<\)0.0001 & 0.004 (\(-\)0.004 to 0.011) & 0.3653 \\ \cline{2-6}  & Maximum LDL concentration & 0.075 (0.045 to 0.105) & \(<\).0001 & \(-\)0.004 (\(-\)0.033 to 0.024) & 0.7593 \\ \cline{2-6}  & SmartFFR & 0.385 (0.116 to 0.654) & 0.0052 & \(-\)0.027 (\(-\)0.379 to 0.326) & 0.8816 \\ \hline \multirow{7}{*}{Lumen area reduction by 20\%} & Diabetes Mellitus & \(-\)0.180 (\(-\)0.316 to \(-\)0.045) & 0.0093 & 0.068 (\(-\)0.152 to 0.289) & 0.5393 \\ \cline{2-6}  & Hypertension & \(-\)0.077 (\(-\)0.161 to 0.006) & 0.0700 & \(-\)0.101 (\(-\)0.229 to 0.028) & 0.1221 \\ \cline{2-6}  & CE\_16\_0 (\mu\)M) & \(-\)0.000 (\(-\)0.000 to 0.000) & 0.0330 & \(-\)0.000 (\(-\)0.001 to 0.000) & 0.5564 \\ \cline{2-6}  & CE\_16\_1 (\mu\)M) & \(-\)0.000 (\(-\)0.001 to 0.000) & 0.0609 & \(-\)0.000 (\(-\)0.001 to 0.000) & 0.5856 \\ \cline{2-6}  & CE\_18\_1 (\mu\)M) & \(-\)0.000 (\(-\)0.000 to 0.000) & 0.0439 & 0.000 (\(-\)0.000 to 0.000) & 0.8448 \\ \cline{2-6}  & PS\_36\_1 (\mu\)M) & 0.007 (\(-\)0.001 to 0.015) & 0.0865 & \(-\)0.000 (\(-\)0.001 to 0.001) & 0.7504 \\ \cline{2-6}  & Baseline plaque & \(-\)0.006 (\(-\)0.007 to \(-\)0.006) & \(<\) 0.0001 & \(-\)0.004 (\(-\)0.005 to \(-\)0.002) & \(<\)0.0001 \\ \cline{2-6}  & burden & \(-\)0.006) & \(<\) 0.0001 & \(-\)0.021 (\(-\)0.027 to \(-\)0.014) & \(<\)0.0001 \\ \cline{2-6}  & Minimum ESS (Pa) & \(-\)0.102 (\(-\)0.117 to \(-\)0.088) & \(<\) 0.0001 & \(-\)0.021 (\(-\)0.027 to \(-\)0.014) & \(<\)0.0001 \\ \cline{2-6}  & Maximum LDL concentration & 0.118 (0.093 to 0.142) & \(<\) 0.0001 & 0.057 (0.017 to 0.097) & 0.0051 \\ \hline \multirow{2}{*}{SmartFFR} & 0.226 (0.011 to 0.441) & 0.0394 & 0.087 (\(-\)0.219 to 0.394) & 0.5720 \\ \cline{2-6}  & \multicolumn{2}{c}{(uM)} & 0.002 (\(-\)0.000 to 0.005) & 0.0892 & - & - \\ \cline{2-6}  & Baseline plaque & \(-\)0.012 (\(-\)0.013 to burden) & \(<\) 0.0001 & \(-\)0.011 (\(-\)0.013 to \(-\)0.010) & \(<\)0.0001 \\ \cline{2-6}  & PS\_38\_6 (\mu\)M) & 0.002 (\(-\)0.000 to 0.004) & 0.0872 & - & - \\ \cline{2-6}  & PS\_40\_6 (\mu\)M) & 0.169 (0.017 to 0.321) & 0.0292 & \(-\)0.12