## 3 Results and Discussion
### Identification and Quantification of Phenolic Compounds by HPLC-PDA  
HPLC-PDA was employed to identify and quantify the individual phenolic compounds of _S. rnmossisima_ extracts (Figure 1). Table 2 summarizes the different phenolic compounds identified and quantified.  
Figure 1: HPLC-PDA chromatogram monitored at 280 nm for (**a**) polyphenol standard mixture of 5 mg/L and for (**b**) salicomia extract (blue and brown lines correspond to CE and MAE extracts, respectively); peak identification: (1) gallic acid, (2) protocatechuic acid, (3) (+)-catechin, (4) chlorogenic acid, (5) vanillic acid, (6) caffe acid, (7) syring acid, (8) (\(-\))-epicatechin, (9) \(p\)-comamic acid, (10) _trans_-ferulic acid, (11) sinaptic acid, (12) naringin, (13) 3,5-di-O-caffeoylquinic acid, (14) quercetin-3-O-galactosidase, (15) rutin, (16) chloridzin, (17) ellagic acid, (18) 3,4-di-O-caffeoylquinic acid; (19) myricetin, (20) cinnamic acid, (21) kaempfer-3-O-glucose, (22) kaempfer-3-O-rutinoside, (23) naringenin, (24) quercetin, (25) phloretin, (26) illioside, (27) kaempfer, (28) apigenin and (29) chrysin.  
According to Table 2, the total amount of phenolic compounds identified and quantified in both extracts were similar. Phenolic acids and flavonoids are the principal constituents of the CE, being responsible of 50% and 40% of the total phenolic composition, respectively. On the other hand, flavonoids are present in highest concentration in MAE, followed by phenolic acids (53% and 43%, respectively). For both extracts, myricetin was the compound present in highest amounts (0.4250 and 0.4655 mg myricetin/g dw for CE and MAE extracts, respectively). Myricetin is a flavonoid well known by its benefits for human health that are based on different pharmacological activities, such as antioxidant, anti-  
cancer, or even immunomodulatory activities, among others [36; 37; 38]. Recently, [PERSON] et al. demonstrated in-vivo the antiproliferative effects of myricetin on endometriosis through cell cycle regulation [39].  
Regarding phenolic acids, gallic acid was the major compound in both extracts (0.2105 and 0.1553 mg gallic acid/g dw, respectively). Catechin and epicatechin were the two flavanols identified and quantified, but CE showed the highest values (0.1116 mg catechin/g dw and 0.0102 mg epicatechin/g dw). Naringin (0.0124 mg/g dw) and naringenin (0.0076 mg/g dw) were only identified and quantified in MAE. Rutin, kaempfer-3-\(O\)-glucose and quercetin-3-\(O\)-galactoside were the principal flavonoids quantified. Apigenin was the flavone found in high amount, with CE extract exhibiting the highest result (0.0045 mg/g dw).  
To the best of our knowledge, this is the first study that analyzed the phenolic profile of _S. ramsissima_. [PERSON] et al. studied the phenolic compounds of three halophyte species, including _S. europaea_, through LC-MS/MS analysis [40]. The authors identified and quantified 11 compounds in the methanolic extract of _S. europaea_. The principal compound reported was rosmarinic acid (346.41 mg/g extract), followed by quinic acid (116.7 mg/g extract). Gallic acid was the compound present in lower amounts (4.24 mg/g extract), being this value inferior to the one reported in our study. [PERSON] et al. characterized by HPLC-ESI-MS/MS two extracts of _Sarcocornia ambigua_, a plant similar to _S. ramsissima_, with different growing conditions [41]. The authors reported the presence of phenolic acids and flavonoids, being ferulic, caffeic, vanillic, \(p\)-coumaric acids, kaempfer and galangin the principal compounds.