## 1 Introduction  
It is well-recognized that clean and high-quality water is certainly fundamental for the health of all livings. It has been globally observed that millions of people are divested of this, and approximately 80% of all human diseases in developing nations are correlated to contaminated water, which leads to an increased number of deaths worldwide. This can lead to more than 14,000 deaths daily [1]. Chronic diseases such as liver cirrhosis occur because of the contamination of drinking water by heavy metals (HMs) such as Cu, Cd,Ni, Cr, and Pb [2]. During the past few decades, urbanization and rapid industrialization have increasingly contaminated the environment with HMs in many countries [34]. Heavy metals can be released into the environment either naturally or anthropogenically [1; 3; 4; 5; 6; 7]. HM contamination, unlike organic contamination, is of great interest because of its high toxicity, concealment, persistence, enrichment, non-degradability, and bioaccumulation in higher trophic levels [4; 6; 8; 9; 10]. However, some HMs (such as Cr, Cu, Fe, Mn, Ni, and Zn) are essential and are needed in small quantities for living organisms because they perform an important role in the metabolism of the human body, with small limits from deficit to toxicity. However, the excessive concentrations of these metals may be toxic [3; 6; 11]. The intake of contaminated food and water is the most important pathway of human exposure to HMs. HMs tend to accumulate in many organs and cause potential health hazards including intracellular accumulated redox-active metals (such as Co, Cr, Cu, and Fe), which catalyze free-radical reactions and disturb the chain of electron transport in the mitochondria, causing the unceasing generation of reactive oxygen species (ROS). This disturbance causes oxidative stress, which then prompts DNA damage, protein modification, and lipid peroxidation [9]. Among HMs, Cu is one of the essential nutrients and biosyntheses that aids in maintaining normal biochemical and physiological tasks in plants, animals, and humans. However, Cu is toxic at high concentrations [10; 12; 13]. The most widespread source of Cu in drinking water is the corrosive action of water leaching Cu pipes in buildings due to increased levels of dissolved oxygen. The health-based standard value of Cu is 2 mg L\({}^{-1}\)[14]. Zinc is also an essential nutrient in almost all food and drinkable water. It acts as a cofactor of various catalytic enzymes in living cells. In addition, it is a vital nutrient that participates in cell division. It performs functions in the growth and development of organs, particularly in pregnant women and infants [14; 15; 16]. Together with Cu, Zn contributes to the mechanisms of antioxidative stress [16]. The dissolution of Zn from pipes is the highest source for a high concentration of Zn. The health-based standard value of Zn is 3 mg L\({}^{-1}\) and the concentrations higher than this are not acceptable for human use [14; 17]. In addition, Mn is a vital metal to human health that acts as a co-factor in the activity of many enzymes. It is needed in order to maintain the functions of the nerve systems and immune cells, as well as for normal development and for regulating the blood sugar and vitamin levels. However, overexposure to Mn can also be toxic to many organs [18]. The main source of Mn is coating on pipes. An Mn concentration below 0.1 mg L\({}^{-1}\) is usually acceptable to humans [14; 17]. Germinated wheat (_Tritcium aestivum_) seeds are new high value-added products that have been presented to the food market as a result of their high nutritional value and their potential to enhance the nutrient uptake, in addition to flavour and taste [19]. Wheat is a major global crop and is a prime source of biologically active substances. It has antioxidative, anti-inflammatory, anticancer, and anti-obesity effects.