# Exploring the Potential of Microextraction in the Survey of Food Fruits and Vegetable Safety
## 2 Extraction Approaches Used to Assess Food Safety
### Conventional Extraction Approaches
** \\ \hline \multirow{8}{*}{UAE/SPE} & A 1 g sample; spiked; 10 mL MeOH/H\({}_{2}\)O & & & \\  & (4:1, \(v/v\)) acidified with 0.2\% FA; 10 min & & & \\  & US; centrifugation 10 min (* repeated two & & & \\  & more times but in the second step, DisQue & & & \\  & salt was added); evaporated to 6 mL; & & 0.001–0.26 ng g\({}^{-1}\) & Banana and & [9] \\  & Oasis PRiME HLB cartridge; eluate was & & & \\  & dried and reconstituted with 0.5 mL & & & \\  & MeOH/UHPLC-MS/MS & & & \\ \hline \multirow{8}{*}{UAE/SPE} & A 0.25–0.5 g sample; lyophilized; 3 mL & & & \\  & 20\% \(v/v\) Mg(NO\({}_{3}\))\({}_{2}\) + 2\% \(v/v\) NH\({}_{3}\); 10 & & & \\  & min (\(\times\)2) US; spiked; diluted to 25 mL & & & \\  & (H\({}_{2}\)O); pH 3; HLB cartridges; elution & & & \\  & (2 \(\times\) 2.5 mL 0.1\% FAc-MeOH (80:20, & & \\  & \(v/v\)))/HPLC-MS/MS & & \\ \hline \multicolumn{6}{l}{Preservatives} \\ \hline \multirow{4}{*}{SLE} & A2 g sample; 2 \(\times\) 5 mL of MeOH solvent; & & & \\  & sonication (30 min); centrifugation; & Parabens (P)—MeP, EtP, & & \\  & supernatant elimination; addition of 5 mL & PrP, BuP, and & & \\  & of MeOH to the extracts; & isoBuP/0.005–0.05 \(\mu\)g g\({}^{-1}\) & & \\  & filtration/HPLC-PDA & & & \\ \hline \multirow{4}{*}{SLE} & Sample-25\% EtOH (solvent); stirring (1 h) & & & \\  & at 45 °C; centrifugation (15 min); & & & \\  & supernatant collection; dry; resuspension & & & \\  & (H\({}_{2}\)O)/HPLC-DAD & & & \\ \hline \multirow{4}{*}{UAS/SPE} & A 2 g sample; 6 mL ACN; & & & \\  & homogenization; 10 min US; & A total of 24 EDCs & & \\  & centrifugation (10 min); supernatant & including alkylphenols, & & \\  & cloclino; dry to 200 \(\mu\)L; reconstitution & BPA, phenylphenols, & & \\  & (10 mL H\({}_{2}\)O); pH 4; SPE cartridge; elution & & & \\  & (400 \(\mu\)L. ACN); evaporation to 25 \(\mu\)L; & & & \\  & 70 \(\mu\)L + 1% TMCS mixture for & & & \\  & derivatization/GC-MS & & & \\  & & & \\ \hline \multirow{8}{*}{QuECHERS/dSPE} & J\multicolumn{1}{c}{J\multicolumn{1}{c}{J \begin{tabular}{} \end{tabular}  } } & \multirow{8}{*}{ \begin{tabular}{} \end{tabular}  } & \begin{tabular}{} \end{tabular}  \\  & J\multicolumn{1}{c}{J \begin{tabular}{} \end{tabular}  } & & & \\  & (5 min); 5 mL supernatant; pH 6; 1.5 g & PG, TBHQ, NDGA, 3-BHA, & & \\  & MgSO\({}_{4}\) + 250 mg NaCl; vortex (1 min); & 2-BHA, 2,6-BHP, 3,5-BHT, & & \\  & 4 mL ACN; vortex (5 min); centrifugation & 4-HRC, FA, LG, and & & \\  & (10 min); collection (1 mL); 200 mg PSA; & & & \\  & vortex (1 min); centrifugation & & & \\  & (5 min)/GC-MS/MS & & & \\ \hline \multirow{8}{*}{QuECHERS/dSPE} & J\multicolumn{1}{c}{J\multicolumn{1}{c}{ \begin{tabular}{} \end{tabular}  } } & \multirow{8}{*}{\ \begin{tabular}{} \end{tabular}  } & \begin{tabular}{} \end{tabular}  \\  & & & \\ \cline{1-1} \cline{3-3}  & & & & \\ \cline{1-1} \cline{3-3}  & & & \\ \cline{1-1} \cline{3-3}  & & & & \\ \cline{1-1} \cline{3-PBS: phosphate buffered saline; PDA: photodiode array detector; PE: petroleum ether; PG: propyl gallate; PrP: propyl paraben; PSA: primary secondary amine; QuEChERS: Quick, Easy, Cheap, Effective, Rugged, and Safe; SALE: sailing-out liquid extraction; SC-CO\({}_{2}\); supercritical carbon dioxide; SFE: supercritical-fluid extraction; SPOME: solidification of floating organic drop microextraction; SLE: solid-liquid extraction; SPE: solid-phase extraction; TBIQ: _tert_-butyl hydroxyquinone; TMCS: trimethylchlorosilane; IQ: tandem quadrupole; UAE: ultrasound-assisted extraction; UHPSE: ultra-high pressure supercritical-fluid extraction; UPLC: ultra-high performance liquid chromatography; US: ultrasonic bath; UV: ultraviolet detector; \"...\" means the respective information is not available.