## 4 Conclusions and Future Perspectives  
Within the present study, highly bioactive compounds of amphiphilic polarity were detected in the TAC extracts from both apple juice and its bio-wastes (apple-pomace), with antioxidant activities mainly attributed to their phenolic bioactives (phenolic acids and flavonoids) and carotenoids, as well as with strong antiplatelet effects against the standard platelet agonist ADP and anti-inflammatory qualities against the potent thrombol inflammatory mediator, PAF, respectively. These are mainly attributed to the rich-in-UFA polar lipids present in these extracts, which, however, may act in synergy with the coherent phenolics and carotenoids for these activities. A structure activity relationship was observed to be relevant to these activities, as the LC-MS analysis identified the main polar lipids belonging to specific phospholipids (PE, PC and PI) and glycolipids (DGDG, MGDG and SQDG) subclasses, with their UFA being mostly in their sn2 position of their structure, which further highlights their significant potential as bioactive compounds, with anti-inflammatory and antithrombotic benefits against inflammation and oxidative stress complications and associated disorders. Nevertheless, further research, both in vitro and in vivo in clinical studies, are needed to fully unveil the potential of the observed beneficial properties of Starking apple products (i.e., juice) and their by-products (apple pomace), and their effect on inflammatory disorders solely as extracts or as bioactive ingredients in functional products with health promoting properties, such as wheat bread, pasta, cookies and even cosmetic formulations like creams and emulsions. At the same time, there has been a strong focus on reducing waste and its management costs, which is pushing industries to adopt more sustainable practices, in a circular economy design as mandated by the UN. This highlights the importance of innovative use of available resources such as agri-food by-products, including apple bio-wastes like apple pomace, that were also found to contain so many valuable bioactives in the present study. The growing demand for apple juice, cider and vinegar is driving the production of large quantities of apple pomace, which can be a natural and sustainable source of the biofunctional compounds detected in the present study. This conversion of waste into valuable nutritional bioactive ingredients for food and other industries such as cosmetics and pharmaceuticals is important, enhancing thus their sustainability importance, while offering economic benefits. Nevertheless, as aforementioned, further research and awareness among food companies is needed to fully utilize the bioactive components of apple pomace in functional foods, nutraceuticalals, cosmeceuticals and/or pharmaceuticals, thus reducing waste and benefiting both the environment and the juice and cider industries. **Author Contributions:** Conceptualization, A.T.; methodology, A.T. and S.K.S. ; software, all authors; validation, A.T.; formal analysis, all authors; investigation, A.T. and C.P. ; resources, A.T. and S.K.S. ; data curation, all authors; writing--original draft preparation, A.T., M.V. and C.P. ; writing--review and editing, A.T., A.O. and S.K.S. ; visualization, A.T.; supervision, A.T.; project administration, A.T.; All authors have read and agreed to the published version of the manuscript. **Funding:** This research received no external funding. **Institutional Review Board Statement:** The anti-inflammatory and antithrombotic properties of shrimp bioactives (natural bioactives) of this study was conducted in platelets from healthy volunteers, in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of DEMOCRTUS UNIVERSITY OF THRACE (protocol code AITO/EHAE/7690/70 on the 27 th of September of 2024). **Informed Consent Statement:** Informed consent was obtained from all healthy blood donors involved in the study. **Data Availability Statement:** All data are contained within the article.