# Exploring the Potential of Microextraction in the Survey of Food Fruits and Vegetable Safety
## 2 Extraction Approaches Used to Assess Food Safety
### Conventional Extraction Approaches
\begin{table}
\begin{tabular}{l l l l l} \hline
**Extraction Method** & **Description/Analytical Technique** & **Contaminants/LODs** & **Matrix** & **Ref.** \\ \hline \multirow{8}{*}{QuEChERS (a) SLE/dSPE (b)} & A (a) 10 g sample; (10 mL H\({}_{2}\)O in & & & \\  & oranges); 10 mL ACN; 4 g MgSO\({}_{4}\) + 1 g & & & \\  & NaCl; agitation (1 min); centrifugation & & & \\  & (10 min); UHPLC-Q-Orbitrap-MS\({}^{2}\); & 21 triazoles and & Orange, grape, & \\  & (b) 10 g sample; (10 mL H\({}_{2}\)O in orange & 5 pesticides metabolites/ & & \\  & samples); 10 mL ACN (or 10 mL ACN & 0.05–2 mg kg\({}^{-1}\) & strawberry & \\  & containing 1\% (\%) / FAc; agitation (1 min); & & \\  & centrifugation (10 min); (dSPE clean-up in & & \\  & oranges)/UHPLC-Q-Orbitrap-MS\({}^{2}\) & & & \\ \hline \multirow{8}{*}{QuEChERS/dSPE} & A 10 g sample; 10 mL ACN; agitation & & & \\  & (10 min); agitation (1 min); 4 g MgSO\({}_{4}\) + & & & \\  & 1 g NaCl Cl + 1 g C\({}_{6}\)H\({}_{9}\)Na\({}_{3}\)O\({}_{9}\) + 0.5 g & & & \\  & C\({}_{6}\)H\({}_{8}\)Na\({}_{2}\)O\({}_{8}\); agitation (1 min); & & & \\  & centrifugation (5 min); 2 mL supernatant + 25 mg PSA + 150 mg MgSO\({}_{4}\); & & & \\  & 25 mg PSA + 5 mg GCB + 150 mg MgSO\({}_{4}\); & & & \\  & vortex (30 s); centrifugation (2 min); dry; & & & \\  & redissove (acetone)/GC-MS/MS & & & \\ \hline \multirow{8}{*}{QuEChERS/dSPE} & A 10 g sample; 0.1\% FAc in ACN; agitation & & & \\  & agitation; 1.5 g NaOAC + 6 g MgSO\({}_{4}\) + & & & \\  & agitation (1 min); centrifugation (5 min); & & & \\  & 1 mL supernatant + 25 mg PSA + 150 mg MgSO\({}_{4}\); & & & \\  & MgSO\({}_{4}\); vortex (1 min); centrifugation & & & \\  & (5 min)/LC-MS/MS & & & \\ \hline \multirow{8}{*}{QuEChERS/dSPE} & A 10 g sample; 10 mL ACN; agitation & & & \\  & (10 min); 4 g MgSO\({}_{4}\) + 1 g NaCl + 0.5 g & & & \\  & C\({}_{6}\)H\({}_{8}\)Na\({}_{3}\)O\({}_{7}\) + 1 g C\({}_{6}\)H\({}_{8}\)O\({}_{7}\); vortex (1 min); & & & \\  & centrifugation (2 min); 2 mL supernatant + 25 mg PSA + 150 mg & & & \\  & vortex (30 s); centrifugation & & & \\  & (2 min)/LC-MS/MS & & & \\  & (2 min)/LC-MS/MS & & & \\ \hline \multirow{8}{*}{QuEChERS/dSPE} & A 5 g sample; 20 mL ACN (+10 mL H\({}_{2}\)O for longan and Chinese cabbage); & & & \\  & agitation (2 min); 4 g MgSO\({}_{4}\) + 1 g NaCl + 0.5 g & & & \\  & 0.25 g C\({}_{6}\)H\({}_{8}\)Na\({}_{2}\)O\({}_{7}\) + 0.5 g C\({}_{6}\)H\({}_{5}\)Na\({}_{3}\)O\({}_{7}\); & & & \\  & agitation (1 min); centrifugation (5 min); & & & \\  & 2 mL supernatant + 150 mg C\({}_{18}\) + 150 mg MgSO\({}_{4}\); agitation (1 min); centrifugation & & & \\  & (5 min)/HPLC-MS/MS & & & \\ \hline \multirow{8}{*}{QuEChERS/dSPE} & A 5 g sample; 10 mL ACN; vortex (5 min); & & & \\  & 4 g NaCl; agitation (1 min); centrifugation & & & \\  & (5 min); 1 mL supernatant + 20 mg GCB; & & & \\  & vortex (1 min); stand (1 min)/LC-MS/MS & & & \\ \hline \multirow{8}{*}{Antibiotics} & & & & \\ \hline \multirow{8}{*}{UAE/SPE} & A 1 g sample + 10 mL MeOH + 15 min US; centrifugation 15 min; supernatant & & & \\  & collection; evaporation to 1 mL; + 10 mL & & & \\ \cline{1-1}  & H\({}_{2}\)O; Strata-X cartridge; elution with 2 mL MeOH; dry; reconstitution (H\({}_{2}\)O); & & & \\ \cline{1-1}  & spiked/UPLC-TQ & & & \\ \hline \end{tabular}
\end{table} 
Table 1: _Cont._  
\begin{table}
\begin{tabular}{l l l l l l} \hline \hline
**Extraction Method** & **Description/Analytical Technique** & **Contaminants/LODs** & **Matrix** & **Ref.