## 2 Materials and Methods
### Study Cohort
\begin{table}
\begin{tabular}{c c c c c c c c} \hline \hline
**Variable** & **Population** & **Cluster A** & **Cluster B** & **Cluster C** & **Cluster D** & **Cluster E** & **Significant Comparisons** \\  & **Summary** & **(in 23)** & **(in = 23)** & **(in = 30)** & **(in = 19)** & **(in = 29)** & **Significant Comparisons** \\ \hline \multicolumn{1}{c}{Stroke (\%)} & 1.6\% (0.09,19.2) & 0.07\% (0.00,0.0) & 4.4\% (0.12,17.0) & 0.07\% (0.00,0.0) & 0.07\% (0.00,0.0) & 3.6\% (0.00,10.5) & - \\ \hline \multicolumn{1}{c}{Syroscope test 12} & \multicolumn{1}{c}{3.7 \(\pm\) 5.3} & \multicolumn{1}{c}{4.1 \(\pm\) 6.7} & \multicolumn{1}{c}{3.8 \(\pm\) 4.5} & \multicolumn{1}{c}{1.7 \(\pm\) 1.6} & \multicolumn{1}{c}{3.89 \(\pm\) 3.16} & \multicolumn{1}{c}{5.5 \(\pm\) 7.5} & \multicolumn{1}{c}{B \(\pm\) C \(\
u\) = 045, C \(\pm\) D \(\
u\) = 0.006} \\  & \multicolumn{1}{c}{} & \multicolumn{1}{c}{} & \multicolumn{1}{c}{} & \multicolumn{1}{c}{} & \multicolumn{1}{c}{} & \multicolumn{1}{c}{} & \\ \hline Total number of \(g\) & \multicolumn{1}{c}{8.6 \(\pm\) 11.7} & \multicolumn{1}{c}{9.7 \(\pm\) 11.8} & \multicolumn{1}{c}{10.5 \(\pm\) 15.7} & \multicolumn{1}{c}{4.6 \(\pm\) 4.1} & \multicolumn{1}{c}{10.7 \(\pm\) 13.0} & \multicolumn{1}{c}{8.9 \(\pm\) 12.0} & - \\ \hline \multicolumn{1}{c}{Inliers list} & \multicolumn{1}{c}{1.0 \(\pm\) 1.7} & \multicolumn{1}{c}{0.5 \(\pm\) 0.8} & \multicolumn{1}{c}{1.3 \(\pm\) 2.2} & \multicolumn{1}{c}{0.9 \(\pm\) 1.9} & \multicolumn{1}{c}{1.6 \(\pm\) 2.5} & \multicolumn{1}{c}{0.9 \(\pm\) 0.9} & \\ \hline \multicolumn{1}{c}{Daytime Trendness} & 48.8\% (0.61,61.4) & 60.9\% (0.00,90.8) & 34.8\% (53.54,53.4) & 20.0\% (57.34,3) & 42.1\% (0.99,64.3) & 85.7\% (728,98.7) & \multicolumn{1}{c}{A \(\times\) C \(\
u\) = 0.006, B \(\pm\) C \(\
u\) = 0.001, C \(\times\) E \(\
u\) = 0.001, D \(\times\) E \(\
u\) = 0.001} & \\ \hline \multicolumn{1}{c}{Natural} & \multicolumn{1}{c}{52.0\% (0.98,64.3)} & 47.8\% (27.4,68.2) & 69.6\% (0.08,88.4) & 40.0\% (22.5,57.5) & 42.1\% (0.99,64.3) & 60.7\% (42.6,78.8) & - \\ \hline \multicolumn{1}{c}{Lack of} & \multicolumn{1}{c}{35.0\% (0.27,49.2)} & 26.1\% (81.4,40) & 26.1\% (81.4,40) & 16.7\% (33.30,30) & 36.8\% (52.85,85) & 67.9\% (506,85.2) & \multicolumn{1}{c}{A \(\times\) E \(\
u\) = 0.007, B \(\pm\) P = 0.007, C \(\times\) E \(\
u\) = 0.001} & \\ \hline \multicolumn{1}{c}{Witnessed groups} & 19.5\% (0.7,35.4) & 17.4\% (19.32,9.2) & 13.0\% (0.0,26.8) & 6.7\% (0.01,156) & 15.8\% (0.3,32.2) & 42.9\% (42.54,61.2) & \multicolumn{1}{c}{B \(\pm\) C \(\
u\) = 0.004, C \(\times\) E \(\
u\) = 0.004} & \\ \hline \multicolumn{1}{c}{Aplyvia spokes} & 8.9\% (0.0,258.0) & 21.7\% (49.36,86) & 8.7\% (0.0,20.2) & 3.3\% (0.98,98) & 0.0\% (0.0,0.0) & 10.7\% (0.20,22.2) & - \\ \hline \multicolumn{1}{c}{Non-fasting} & \multicolumn{1}{c}{3.0\% (0.8,62.9)} & 69.6\% (0.08,8.4) & 30.4\% (11.6,92) & 30.3\% (16.5,50.2) & 36.8\% (152.8,58.7) & 78.6\% (634.9,38.0) & \multicolumn{1}{c}{A \(\times\) E \(\
u\) = 0.001, D \(\times\) E \(\
u\) = 0.001} & \\ \hline \multicolumn{1}{c}{Egrowth} & \multicolumn{1}{c}{8.5 \(\pm\) 6.5} & \multicolumn{1}{c}{11.9 \(\pm\) 6.2} & \multicolumn{1}{c}{5.8 \(\pm\) 5.4} & \multicolumn{1}{c}{4.2 \(\pm\) 3.9} & \multicolumn{1}{c}{9.5 \(\pm\) 6.9} & \multicolumn{1}{c}{11.7 \(\pm\) 6.1} & \multicolumn{1}{c}{A \(\times\) B \(\
u\) = 0.001, A \(\times\) C \(\
u\) = 0.001, B \(\times\) E \(\
u\) = 0.001} & \\ \hline \multicolumn{1}{c}{Average RR} & 96.74\% \(\pm\) 152.86 & 99.40\% \(\pm\) 150.97 & 95.13\% \(\pm\) 140.78 & 1034.7\% \(\pm\) 157.37 & 954.6\% \(\pm\) 132.73 & 89.89\% \(\pm\) 136.89 & \multicolumn{1}{c}{A \(\times\) E \(\
u\) = 0.001, C \(\times\) E \(\
u\) = 0.001, B \(\times\) E \(\
u\) = 0.001, D \(\times\) E \(\
u\) = 0.001} & \\ \hline \multicolumn{1}{c}{SDNN} & 132.75 \(\pm\) 132.12 & 100.57 \(\pm\) 29.84 & 80.52 \(\pm\) 26.79 & 140.93 \(\pm\) 166.27 & 266.37 \(\pm\) 206.88 & 102.64 \(\pm\) 90.21 & \multicolumn{1}{c}{B \(\times\) D \(\
u\) = 0.001, C \(\times\) D \(\
u\) = 0.001, D \(\times\) E \(\
u\) = 0.001} & \\ \hline \multicolumn{1}{c}{SDNN index} & 93.44 \(\pm\) 64.54 & 68.96 \(\pm\) 22.39 & 54.87 \(\pm\) 21.82 & 84.33 \(\pm\) 0.26 & 214.3\% \(\pm\) 47.77 & 72.93 \(\pm\) 46.53 & \multicolumn{1}{c}{A \(\times\) E \(\
u\) = 0.000, C \(\times\) E \(\
u\) = 0.001, B \(\times\) E \(\
u\) = 0.001} & \\ \hline \multicolumn{1}{c}{RMSD} & 110.39 \(\pm\) 103.84 & 88.22 \(\pm\) 24.68 & 62.17 \(\pm\) 32.23 & 88.17 \(\pm\) 68.