## 3 Results  
The results of measurements before and after the series of treatments were compared to evaluate procedure effectiveness (Table 1). A statistically significant (\(p<0.0001\)) improvement in skin viscoelasticity (parameter R6 cutometer) was demonstrated for both the left and right eyes. The improvement was observed in 32 of 39 subjects (82.1% of subjects) for the right eye (carboxytherapy) and in 34 of 39 subjects (87.2% of subjects) for the left eye--a combined procedure. The changes in Corneometer measurements were statistically insignificant; however, skin hydration was improved in 59% of subjects in the right-eye area and in 74.4% of subjects in the left-eye area (Table 2). The analysis of the efficacy of carboxytherapy (right) in monotherapy and the treatment including carboxytherapy and acids (left) revealed that both treatments were effective. There were no statistically significant differences in treatment results, assessed with the use of the Corneometer and the Cutometer, between both therapies (Table 2). The combination of carboxytherapy and lactobionic acid was used in 25 individuals. The improvement in hydration was observed in 80% of them following the therapy. Carboxytherapy in combination with ferulic acid and ascorbic acid was performed in 14 patients and the improvement was observed in 64% of cases. This shows that lactobionic acid has stronger moisturizing properties compared to ferulic and ascorbic acids. In 92.9% of individuals treated with ferulic and ascorbic acid, an improvement in viscoelasticity was demonstrated (R6). It cannot be ruled out that carboxytherapy improves hydration since its higher values were found in 59% of study participants after applying therapy. In turn, the improvement in the hydration within the area of the left eye was observed in 74.4% of individuals after combined therapy. Slight differences in viscoelasticity (R6) were demonstrated between the right and left sides (82.1% vs. 87.2%, respectively). The analysis of changes in studied parameters in age groups (25-40 years vs. 41-55 years) is presented in Table 3. This analysis demonstrated that, in both age groups, applied treatments were associated with similar improvement. Based on photographic documentation and the case descriptions presented in Figure 2, generalized and simplified outcomes of the treatments were assessed. A series of carboxytherapy treatments combined with selected acids demonstrated diverse benefits in improving the appearance of the periodital area across different patients. Treatments with lactobionic acid resulted in noticeable smoothing of the skin, reduction in fine wrinkles associated with dryness, brightening of the skin, and diminishing vascular shadows. In contrast, the combination of carboxytherapy with ferulic and ascorbic acid led to an improvement in skin texture, reduction in the depth of wrin \begin{table}
\begin{tabular}{l c c c} \hline \hline \multirow{2}{*}{**Parameter**} & \multicolumn{3}{c}{**Time Point**} & \multirow{2}{*}{\(p\)} \\ \cline{2-3} \cline{5-5}  & **Baseline** & **After Treatment** & \\ \hline n = 39 & & Right Eye & \\ \hline Corneometer [units] & 70.6 \(\pm\) 9.6 & 73.3 \(\pm\) 8.9 & NS (\(p\) = 0.101) \\ \cline{2-3} [\% vs. baseline] & & 0.8 (\(-\)4.1; 9.0) & — \\ \cline{2-3} Improvement—n [\%] & & & \\ \hline R6 [units] & 0.422 \(\pm\) 0.171 & 0.313 \(\pm\) 0.132 & \textless{}0.0001 \\ \cline{2-3} [\% vs. baseline] & & \(-\)18.3 (\(-\)43.2; \(-\)2.1) & — \\ \cline{2-3} Improvement—n [\%] & & 32 [82.1] & — \\ \hline n = 39 & & Left Eye & \\ \hline Corneometer [units] & 72.4 \(\pm\) 11.1 & 74.7 \(\pm\) 8.3 & NS (\(p\) = 0.052) \\ \cline{2-3} [\% vs. baseline] & & 2.5 (\(-\)3.4; 9.4) & — \\ \cline{2-3} Improvement—n [\%] & & 29 [74.4] & — \\ \hline R6 [units] & 0.409 \(\pm\) 0.211 & 0.255 \(\pm\) 0.106 & \textless{}0.0001 \\ \cline{2-3} [\% vs. baseline] & & \(-\)32.0 (\(-\)50.9; \(-\)10.0) & — \\ \cline{2-3} Improvement—n [\%] & & 34 [87.2] & — \\ \hline \hline \end{tabular}
\end{table}