# The Less Known Cyclins--Uncovered
## 14 Summary
\begin{table}
\begin{tabular}{c c c} \hline \hline
**Protein** & **Function in Normal Cells** & **References** \\ \hline \multicolumn{3}{c}{RNAPII transcription in complex} \\  & with Cdk8 & \\  & Transmission of the oxidative stress & [PERSON] et al., 2019 [7] \\ Cyclin C & Cell’s exit from the G0 phase through & [PERSON] et al., 2019 [10] \\  & phosphorylation of the & [PERSON] et al., 2004 [12] \\  & retinoblastoma protein (Rb) in & [PERSON] et al., 1998 [14] \\  & complex with Cdk3 & \\  & Regulation of G1 and G2 phases & \\ \hline \multirow{4}{*}{Cyclin F} & & [PERSON] et al., 2010 \\  & Synthesis, stability and repair of DNA & [24] \\  & Transcription & [PERSON] et al., 2012 \\  & Cell proliferation & [25] \\  & Embryogenesis & [PERSON] et al., 2015 [27] \\  & & [PERSON] et al., 2004 [28] \\ \hline \multirow{2}{*}{Cyclin G} & Transcription & [PERSON] et al., 2004 [36] \\  & The p53-Mdm2 pathway & [PERSON] et al., 2002 [37] \\ \hline \multirow{2}{*}{Cyclin H} & Transcription in the CAK complex & [PERSON] et al., 2010 [49] \\ \hline \multirow{4}{*}{Cyclin I} & Cell cycle & \\  & Protection of podocytes from & [PERSON] et al., 2013 [54] \\  & apoptosis after mitosis & [PERSON] et al., 2006[55] \\  & Final arrest of growth of & [PERSON] et al., 2007 [56] \\  & cardiomyocytes & \\ \hline \multirow{4}{*}{Cyclin J} & Early embryogenesis in complex with & [PERSON] et al., 2000 [60] \\  & Cdk2 & [PERSON] et al., 2014 [61] \\ \hline \multirow{4}{*}{Cyclin K} & RNAPII transcription in complex & [PERSON] et al., 2002 [71] \\  & with Cdk9, Cdk12 or Cdk13 & [PERSON] et al., 2012 [70] \\  & DNA repair and genome stability in & [PERSON] et al., 2011 [72] \\  & complex with Cdk12 & \\ \hline \multirow{2}{*}{Cyclin L} & Regulation of pre-mRNA splicing in & \\  & complex with Cdk11 & [PERSON] et al., 2008 [75] \\ \hline \multirow{4}{*}{Cyclin M} & Ciliogenesis process in complex with & \\  & Cdk10 & [PERSON] et al., 2017[83] \\  & Regulation of the protein C-ets-2 (ETS2) transcription factor in complex & [PERSON] et al., 2013 [87] \\  & with Cdk10 & \\ \hline \multirow{4}{*}{Cyclin O} & Process of central cell amplification & [PERSON] et al., 2015 [94] \\  & Development of oocytes & [PERSON] et al., 2013 [95] \\  & Normal development of the body & [PERSON] et al., 2017 \\ \hline \multirow{4}{*}{Cyclin T} & RNAPII transcription in complex & \\  & with Cdk9 & \\  & Differentiation of muscle cells in & \\  & complex with Cdk9 & [PERSON] et al., 2001 [100] \\  & Presentation and processing of & [PERSON] et al., 1998 [102] \\  & antigen in complex with Cdk9 & [PERSON] et al., 2001 [101] \\  & Cell proliferation in complex with [PERSON] [PERSON] et al., 2008 [104] \\  & Differentiation and activation B-cell & \\  & in complex with Cdk9 & \\ \hline \multirow{4}{*}{Cyclin Y} & Wnt-B-catenin pathway in complex & [PERSON] et al., 2009 [110] \\  & with Cdk14 & [PERSON] et al., 2012 \\ \cline{1-1}  & Spermat in complex with & [108] \\ \cline{1-1}  & Cdk16 & \\ \hline \hline \end{tabular}
\end{table} 
Table 1: The biological functions of the less-known cyclins in normal cells. **Author Contributions:** A.Z. : funding acquisition, writing--cyclin C and G chapters; A.O. : writing--cyclin H, I, J, K, L, M and Y chapters; W.Z. : writing--cyclin T chapter and original draft editing; A.G.: supervision, resource investigation and draft editing; A.K. : writing--cyclin F and O chapters and figures preparation. All authors have read and agreed to the published version of the manuscript. This work was supported by the Nicolaus Copernicus University, Collegium Medicicum (grant 114/2019). The cyclins expression profiles in human lung cancer endothelial cells were generated using The Endothelial Cell Database (EndoDB: [[https://endothelomics.shinyapps.io/endodb/](https://endothelomics.shinyapps.io/endodb/)]([https://endothelomics.shinyapps.io/endodb/](https://endothelomics.shinyapps.io/endodb/)) (accessed on 19 February 2021)) through ssCycle tool. The authors declare no conflict of interest.