## 2 Materials and Methods  
### Synthesis of Compounds  
Tested esters and ketones of phenolic acids were synthesized as previously reported [27; 28; 29; 30; 31]. Descriptions of the NMR analyzes of the seven selected compounds (**1**, **12**, **16**, **26**, **35**, **42**, **44**) after the first screening are as follows:(E)-3-Phenylpropyl 3-(3,4-dihydoxyphenyl)acrylate (1) was synthesized according to the procedure that we previously reported [30]. The product was purified by flash chromatography; white solid; yield: 81%; 1H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\) (ppm): 9.63 (br s, 1H, OH), 9.18 (br s, 1H, OH), 7.47 (d, J = 16 Hz, 1H, =CHC\({}_{\rm ar}\)), 7.29 (t, J = 7.4 Hz, H\({}_{\rm ar}\)), 7.24-7.17 (m, 3H, H\({}_{\rm ar}\)), 7.06 (s, 1H, H\({}_{\rm ar}\)), 7.02 (d, J = 9.1 Hz, H\({}_{\rm Ar}\)), 6.77 (d, J = 8 Hz, 1H, Har), 6.28 (d, J = 16 Hz, 1H, =CHCO), 4.11 (t, J = 6.4 Hz, 2H, CH\({}_{2}\)CH\({}_{2}\))\({}_{2}\)Ph), 2.68 (t, J = 7.44 Hz, 2H, (CH\({}_{2}\))\({}_{2}\)CH\({}_{2}\)Ph), 1.94 (quint., J = 6.8 Hz, 2H, CH\({}_{2}\)CH\({}_{2}\)CH\({}_{2}\)Ph); \({}^{13}\)C NMR (101 MHz, DMSO-\(d_{6}\)) \(\delta\) (ppm): 167.06, 148.85, 146.02, 145.55, 141.68, 128.81, 128.78, 126.33, 125.97, 121.84, 116.18, 115.29, 114.39, 63.58, 31.96, 30.36 (1H and 13C NMR spectra were included in the Supplementary Materials). Phenethyl-2-(3,4-dihydoxyphenyl)acetate (**12**) was synthesized according to the procedure that we previously reported [29]. The product was purified by flash chromatography; yellow oil; yield: 63%; 1H NMR (CD\({}_{3}\)OD); \(\delta\) (ppm): 7.27-7.14 (m, 5H, H\({}_{\rm ar}\)), 6.72-6.70 (m, 2H, H\({}_{\rm ar}\)), 6.54 (dd, J = 8.0 Hz, 1.7 Hz, 1H, H\({}_{\rm ar}\)), 4.27 (t, J = 6.8 Hz, CH\({}_{2}\)CH\({}_{2}\)Ph), 3.44 (s, 2H, Ca\({}_{x}\)CH\({}_{2}\)CO), 2.89 (t, J = 6.8 Hz, 2H, CH\({}_{2}\)CH\({}_{2}\)Ph); \({}^{13}\)C-NMR (CD\({}_{3}\)OD); \(\delta\) (ppm): 172.56, 144.91, 144.06, 137.91, 128.59, 128.04, 126.05, 125.51, 120.28, 116.04, 114.92, 65.13, 40.14, 34.60 (1H and 13C NMR spectra were included in the Supplementary Materials). Phenethyl 3,4,5-trihydroxybenzoate (**16**) was synthesized according to the procedure that we previously reported [31; 32]. The product was purified by flash chromatography; white solid; yield: 67%; 1H NMR (400 MHz, CDCl\({}_{3}\)), \(\delta\) (ppm): 7.36-7.26 (m, 7H), 4.51 (t, J = 7.0 Hz, 2H, CH\({}_{2}\)CH\({}_{2}\)Ph), 3.07 (t, J = 7.0 Hz, 2H, CH\({}_{2}\)CH\({}_{2}\)Ph), 13C NMR (100 MHz, CDCl\({}_{3}\)) \(\delta\) (ppm): 166.48, 143.39, 137.74, 136.48, 128.94, 128.59, 126.65, 121.73, 65.75, 35.17 (1H and 13C NMR spectra were included in the Supplementary Materials). 3-(4-Methoxyphenyl)prop-2-yn-1-yl (2E)-3-[3,4-dihydroxyphenyl]prop-2-enoate (**26**) was synthesized according to the procedure that we previously reported [28]. The product was purified by flash chromatography; pale brown solid; yield: 96%; 1H NMR (400 MHz, DMSO-\(d_{6}\)), \(\delta\) (ppm): 9.50-9.20 (m, 2H, OH), 7.55 (d, 1H, J = 16 Hz, =CHC\({}_{\rm ar}\)), 7.41 (d, 2H, J = 8.6 Hz, H\({}_{\rm ar}\)), 7.09 (s, 1H, H\({}_{\rm ar}\)), 7.04 (d, 1H, J = 8.2 Hz, H\({}_{\rm ar}\)), 6.95 (d, 2H, J = 8.6 Hz, H\({}_{\rm ar}\)), 6.77 (d, 1H, J = 8.2 Hz, H\({}_{\rm ar}\)), 6.34 (d, 1H, J = 16 Hz, =CHCO), 5.03 (s, 2H, CH\({}_{2}\)CC), 3.78 (s, 3H, CH\({}_{3}\)O). 13C NMR (101 MHz, DMSO-\(d_{6}\)), \(\delta\) (ppm): 166.40, 160.19, 149.13, 146.58, 146.04, 133.67, 125.84, 122.15, 116.18, 115.39, 114.83, 113.81, 113.52, 86.19, 83.39, 55.72, 52.70 (1H and 13C NMR spectra were included in the Supplementary Materials). (2E)-3-(4-Methoxyphenyl)prop-2-en-1-yl (2E)-3[3,4-dihydroxyphenyl]prop-2-enoate (**35**) was synthesized according to the procedure that we previously reported [28].