## 5 Conclusions  
The preliminary results of this study show that patients diagnosed with mild-to-moderate Parkinson's disease (stages I-III) can carry out a high-intensity pedaling-based physical exercise protocol and, moreover, accomplish this in an immersive virtual environment. Furthermore, the IVR software (www.oculus.com, accessed on 10 December 2023) and hardware proposed, when employed in combination with smart cycloergometers for the performance of multi-sensory stimulation therapies, are safe, tolerable, and easy to use for people with PD.  
Moreover, the effects of the ReViPark program (high-intensity pedaling + IVR over a period of 3 months) led to improvements in several disease domains. In particular, functional parameters such as strength of the lower train, dynamic balance, and gait are crucial aspects for avoiding falls in PD and ensuring functionality, quality of life, and the symptomatology of the participants as indicators of disease progression in terms of motor and non-motor aspects.  
However, future studies incorporating longer interventions and follow-up assessments are needed to corroborate these findings.  
Finally, this study opens the door to future research opportunities, such as additional aspects of using mixed reality (virtual reality or augmented reality) and the possibility of expanding the program to other pathologies (such as dementia or other neurological conditions) and other methods of virtual rehabilitation (cognitive or mental health-focused therapies).  
**Supplementary Materials:** The following supporting information can be downloaded at: [[https://www.mdpi.com/article/10.3390/app14114708/s1](https://www.mdpi.com/article/10.3390/app14114708/s1)]([https://www.mdpi.com/article/10.3390/app14114708/s1](https://www.mdpi.com/article/10.3390/app14114708/s1)), Table S1. Analysis of the physical parameters of the intervention program, taking into account the three evaluation times of the program and the EG and CG studied.  
**Author Contributions:** Conceptualization, methodology, and formal analysis, P.C.-P., G.R.-F. and J.M.C.-C. (all authors); software, validation, data curation, and visualization, P.C.-P.; resources, G.R.-F. and J.M.C.-C.; writing--original draft preparation, review, and editing, P.C.-P., G.R.-F. and J.M.C.-C. (all authors); supervision, project administration, and funding acquisition, P.C.-P. and J.M.C.-C. All authors have read and agreed to the published version of the manuscript.  
**Funding:** Intramural Call for Biomedical Research Projects 2022, from the Galicia Sur Health Research Institute (IISGS). Code: CI22-B-03.  
**Institutional Review Board Statement:** This study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Servizo Galego de Saide (protocol code 2023/286; date of approval: 14 December 2023).  
**Informed Consent Statement:** Informed consent was obtained from all subjects involved in the study.  
**Data Availability Statement:** The raw data supporting the conclusions of this article will be made available by the authors on request.  
**Acknowledgments:** We are grateful for the collaboration of the therapy staff of the Parkinson's Association of Vigo and the Baixo-Mino Parkinson's Association, as well as all their members, for making this project possible.  
**Conflicts of Interest:** The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.