## 2 Materials and Methods
### Synthesis
(2s, 9H, 3 OCH\({}_{3}\)), 3.92-4.17 (m, 3H, NCH\({}_{2}\), CH), 6.98 (s, 2H, H\({}_{\rm Ar}\)), 7.09-8.10 (m, 3H, H\({}_{\rm Ar}\)), 8.19 (s, 0.67H, CH=N), 8.40 (s, 0.33H, CH=N), 11.69 (s, 0.67H, CONH), 11.78 (s, 0.33H, CONH) ppm. \({}^{13}\)C NMR (101 MHz, DMSO-\(d_{6}\)) \(\delta\): 32.69, 34.82, 35.14, 35.67, 50.35, 50.90, 55.91, 60.11, 97.85, 98.06, 104.50, 112.51, 112.72, 118.49, 128.20, 134.24, 134.28, 135.20, 135.25, 135.86, 152.67, 168.71, 171.71, 171.86, 173.67 ppm. IR (KBr): \(\
u_{\rm max}\): 3121, (NH), 1680, 1651 (2C=O), 1296, 1234 (3 OCH\({}_{3}\)) cm\({}^{-1}\). Anal. Calcd. for C\({}_{21}\)H\({}_{21}\)F\({}_{2}\)N\({}_{3}\)O\({}_{6}\), %: C 58.20; H 4.88; N 9.70. Found: C 58.08; H 4.70; N 9.58. 5-Oxo-\(N^{\prime}\)-(3,4,5-trimethoxybenzylidene)-1-(3,4,5-trimethoxyphenyl)pyrrolidine-3-carbohydrazide **(15)**  
White solid, yield 0.68 g (86%), m. p. 185-187 \({}^{\circ}\)C (from propan-2-ol). \({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\): 2.67-2.91 (m, 2H, CH\({}_{2}\)CO), 3.63, 3.69. 3.75, 3.77, 3.81, 38.2 (6s, 18H, 6 OCH\({}_{3}\)), 3.92-4.20 (m, 3H, NCH\({}_{2}\), CH), 7.00 (s, 4H, H\({}_{\rm Ar}\)), 7.95 (s, 0.60H, CH=N), 8.15 (s, 0.40H, CH=N), 11.61 (s, 1H, CONH) ppm. \({}^{13}\)C NMR (101 MHz, DMSO-\(d_{6}\)) \(\delta\): 32.54, 34.71, 35.29, 35.77, 50.51, 51.07, 55.90, 55.96, 60.12, 97.88, 98.05, 104.20, 104.32, 129.64, 134.24, 135.22, 135.29, 139.10, 139.25, 143.58, 147.07, 152.68, 153.20, 168.63, 171.80, 172.00, 173.69 ppm. IR (KBr): \(\
u_{\rm max}\): 3179, (NH), 1695, 1673 (2C=O), 1290, 1234 (6 OCH\({}_{3}\)) cm\({}^{-1}\). Anal. Calcd. for C\({}_{24}\)H\({}_{29}\)N\({}_{3}\)O\({}^{8}\), %: C 59.13; H 6.00; N 8.62. Found: C 58.98; H 5.91; N 8.54. \(N^{\prime}\)-(2-chlorobenzylidene)-5-oxo-1-(3,4,5-trimethoxyphenyl)pyrrolidine-3-carbohydrazide **(16)**  
Light violet solid, yield 0.5 g (72%), m. p. 136-138 \({}^{\circ}\)C (from propan-2-ol). 1H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\): 2.71-2.89 (m, 2H, CH\({}_{2}\)CO), 3.63, 3.76, 3.77. (3s, 9H, 3 OCH\({}_{3}\)), 3.94-4.17 (m, 3H, NCH\({}_{2}\), CH), 6.87-8.07 (m, 6H, H\({}_{\rm Ar}\)), 8.43 (s, 0.65H, CH=N), 8.62 (s, 0.35H, CH=N), 11.77 (s, 0.65H, CONH), 11.88 (s, 0.35H, CONH) ppm. \({}^{13}\)C NMR (101 MHz, DMSO-\(d_{6}\)) \(\delta\): 32.68, 34.85, 35.17, 35.66, 50.39, 50.91, 55.91, 60.11, 97.84, 98.06, 126.87, 126.92, 127.64, 127.68, 129.92, 131.60, 132.99, 133.17, 134.23, 135.21, 135.25, 139.76, 142.96, 152.67, 168.79, 171.73, 171.87, 173.76 ppm. IR (KBr): \(\
u_{\rm max}\): 3133, (NH), 1673 (2C=O), 1296, 1276, 1235 (3 OCH\({}_{3}\)) cm\({}^{-1}\). Anal. Calcd. for C\({}_{21}\)H\({}_{22}\)ClN\({}_{3}\)O\({}_{5}\), %: C 58.40; H 5.13; N 9.73. Found: C 58.43; H 5.08; N 9.78. \(N^{\prime}\)-(3-chlorobenzylidene)-5-oxo-1-(3,4,5-trimethoxyphenyl)pyrrolidine-3-carbohydrazide **(17)**  
Grayish powder, yield 0.53 g (76%), m. p. 170-172 \({}^{\circ}\)C (from acetone). \({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\): 2.70-2.88 (m, 2H, CH\({}_{2}\)CO), 3.63, 3.76, 3.77. (3s, 9H, 3 OCH\({}_{3}\)), 3.92-4.18 (m, 3H, NCH\({}_{2}\), CH), 7.00 (s, 2H, H\({}_{\rm Ar}\)), 7.38-7.82 (m, 4H, H\({}_{\rm Ar}\)), 8.02 (s, 0.65H, CH=N), 8.21 (s, 0.35H, CH=N), 11.70 (s, 0.65H, CONH), 11.78 (s, 0.35H, CONH) ppm. \({}^{13}\)C NMR (101 MHz, DMSO-\(d_{6}\)) \(\delta\): 32.58, 34.76, 35.24, 35.70, 50.43, 50.94, 55.90, 60.10, 97.85, 98.03, 125.67, 125.76, 126.10, 126.45, 129.57, 130.70, 130.74, 133.64, 133.71, 134.26, 135.20, 135.27, 136.36, 136.41, 142.15, 145.39, 152.67, 168.84, 171.73, 171.90, 173.84 ppm. IR (KBr): \(\
u_{\rm max}\): 3134, (NH), 1682 (2C=O), 1269, 1235 (3 OCH\({}_{3}\)) cm\({}^{-1}\). Anal. Calcd. for C\({}_{21}\)H\({}_{22}\)ClN\({}_{3}\)O\({}_{6}\), %: C 58.40; H 5.13; N 9.73. Found: C 58.30; H 5.02; N 9.63. \(N^{\prime}\)-(2-chloro-5-nitrobenzylidene)-5-oxo-1-(3,4,5-trimethoxyphenyl)pyrrolidine-3-carbohydrazide **(18)**  
Light brown powder, yield 0.66 g (86%), m. p. 199-201 \({}^{\circ}\)C (from propan-2-ol). \({}^{1}\)H NMR (400 MHz, DMSO-\(d_{6}\)) \(\delta\): 2.71-2.92 (m, 2H, CH\({}_{2}\)CO), 3.63, 3.76, 3.77.