## 3 Results
### RCTs (Ozone)
\begin{table}
\begin{tabular}{c c c c c c} \hline \hline
**Articles** & \
\begin{tabular}{c} **Type of** \\ **Study** \\ \end{tabular} & **Problem** & **Intervention/Comparison** &
\begin{tabular}{c} **Clinical** \\ **Indices/Follow-Up** \\ \end{tabular} & **Outcome** \\ \hline
**Seydanur** & & & & & SRP plus gaseous \\
**Dengizek** & RCT & 40 patients with & & & & ozone versus SRP alone \\
**e14** & RCT & moderate generalized & & & Control: SRP & 1 month & does not correlate to a significant \\
**e15** & & chronic periodontitis & & & improvement in \\  & & & & & periodontal recovery. \\ \hline
**Tasdemir** & & 36 patients with & & & Ozone therapy did not \\
**e16** & RCT & moderate and/or & & & & have any additional \\
**e17** & & severe generalized & & Control: SRP & GI; 3 months & effect on periodontal \\  & & & & & parameters. \\ \hline
**[PERSON] et al.,** & RCT &
\begin{tabular}{c} 90 patients with \\ moderate or severe \\ generalized \\ chronic periodontitis \\ \end{tabular} & Test: SRP + ozone gas & & & & & When SRP and ozone \\
**e18** & & chronic periodontitis & & & therapy were used \\  & & & & & together to treat \\  & & & & & periodontitis, the \\  & & & & results were better than \\
**[PERSON] et al.,** & RCT &
\begin{tabular}{c} 10 patients with \\ chronic periodontitis \\ \end{tabular} & Test: SRP + ozone gas & & & & & when SRP was used \\  & & & & Control: SRP & 6 months & alone. From the \\  & & & & & baseline, there was a \\  & & & & & statistically significant \\  & & & & & difference between the \\  & & & & & groups’ scores for CAL, \\  & & & & & PPD \\  & & & & & and BOP. \\ \hline
**[PERSON] et al.,** & \
\begin{tabular}{c} **10 patients with \\ **2020** [51] \\ \end{tabular} & RCT &
\begin{tabular}{c} 10 patients with \\ chronic periodontitis \\ \end{tabular} & Test: SRP + ozone gas & & & & & _T. forsytthia_ and _T. denticola_ were \\  & & & & Control: SRP & samples; 7 days & eradicated in the \\  & & & & & ozone group. \\ \hline
**[PERSON] et al.,** & \
\begin{tabular}{c} 18 patients with \\ generalized \\ chronic periodontitis \\ \end{tabular} & RCT &
\begin{tabular}{c} 18 patients with \\ generalized \\ chronic periodontitis \\ \end{tabular} & Test: SRP + ozone gas & & & & & Ozone therapy did not \\  & & & & & provide additional \\  & & & & & benefits to clinical, \\  & & & & Control: SRP & 3 months & microbiological and \\  & & & & & biochemical parameters \\  & & & & over SRP in chronic \\  & & & & periodontitis patients. \\ \hline
**Al** & & & & & & As an adjuvant therapy \\
**Habashneh** & RCT &
\begin{tabular}{c} 41 patients with \\ chronic periodontitis \\ \end{tabular} & Test: SRP + ozonated & & & & & to SRP, ozonated water \\  & & & water & & & irrigation yields no \\  & & & & & statistically \\  & & & & & significant benefit. \\ \hline
**[PERSON] et al.,** & \
\begin{tabular}{c} **105** \\ \end{tabular} & RCT &
\begin{tabular}{c} 30 patients with \\ chronic periodontitis \\ \end{tabular} & Test: SRP + ozonated & & & & & \\  & & & & microbiological & & irrigation can help \\  & & & & & patients with chronic \\  & & & & & periodontitis by \\  & & & & improving their clinical \\  & & & & & and microbiological \\  & & & & parameters. \\ \hline \hline \end{tabular}
\end{table} 
Table 3: RCTs included (ozone) [48; 49; 50; 51; 52; 53; 54; 55; 56; 57; 58; 59; 57]. The results suggest that ozone as an adjuvant to scaling and root planing offers contrasting clinical results and that further clinical trials are needed to better define its efficacy in improving periodontal tissues and healing processes (secondary outcome); a recent literature review has shown that the use of ozone as an adjunct to nonsurgical periodontal therapy does not bring any additional benefit [14].