# Propolis as Natural Product in the Oral Cavity Bacterial Infections Treatment: A Systematic Review
## 4 Results
### Antibacterial Activity of Propolis in Oral Cavity Bacterial Infections
#### 4.2.1 In Vitro Studies
\begin{table}
\begin{tabular}{c c c c} \hline \hline
**Bacteria** & **MIC** & **MBC** & **Reference** \\ \hline \multirow{6}{*}{_Lactobacillus casei_} & 200–300 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & & [62] \\ \cline{2-4}  & 250 \(\mathrm{\SIUnitSymbolMicro g}\)/mL (ethanol extract) & 250 \(\mathrm{\SIUnitSymbolMicro g}\)/mL (ethanol extract) & [15] \\ \cline{2-4}  & 29.76 mg/mL & 59.52 mg/mL & [14] \\ \cline{2-4}  & 0.6–1.2 mg/mL & 0.6–1.2 mg/mL & [75] \\ \hline \multirow{2}{*}{_Lactobacillus salivarius subsp. salivarius_} & 2.0 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & 4.0 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & [77] \\ \hline \multirow{6}{*}{_Lactobacillus spp._} & 8.0 mg/mL & 16 mg/mL & [67] \\ \cline{2-4}  & 50 mg/mL (aqueous extract) & \multirow{2}{*}{25 mg/mL (aqueous extract)} & [91] \\ \cline{2-4}  & 100 mg/mL (hydroalcoholic extract) & & \\ \cline{2-4}  & 0.7 mg/mL & 5.91 mg/mL & [70] \\ \hline \multirow{2}{*}{_Peptostreptococcus anaerobius_} & 20.8 + 10.1 \(\mathrm{\SIUnitSymbolMicro g}\)/mL * & 32.0 + 18.4 \(\mathrm{\SIUnitSymbolMicro g}\)/mL * & [19] \\ \hline \multirow{6}{*}{_Peptostreptococcus micros_} & 16.0 + 9.2 \(\mathrm{\SIUnitSymbolMicro g}\)/mL * & 19.2 + 11.4\(\mathrm{\SIUnitSymbolMicro g}\)/mL * & [19] \\ \cline{2-4}  & 30–50 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & 200–400 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & [63] \\ \cline{2-4}  & 294.4 + 198.2 \(\mathrm{\SIUnitSymbolMicro g}\)/mL * & 384.0 + 170.6 \(\mathrm{\SIUnitSymbolMicro g}\)/mL * & [19] \\ \cline{2-4}  & 32 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & 64 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & [77] \\ \cline{2-4}  & 500 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & & [92] \\ \hline \multirow{2}{*}{_Prevotella intermediia_} & 8.0 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & 8.0 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & [77] \\ \hline \multirow{2}{*}{_Prevotella melaninogenica_} & 204.8 + 66.0 \(\mathrm{\SIUnitSymbolMicro g}\)/mL * & 381.6 + 132.1 \(\mathrm{\SIUnitSymbolMicro g}\)/mL * & [19] \\ \hline \multirow{2}{*}{_Prevotella oralis_} & 230.4 + 54.0 \(\mathrm{\SIUnitSymbolMicro g}\)/mL * & 460.8 + 107.9 \(\mathrm{\SIUnitSymbolMicro g}\)/mL * & [19] \\ \hline \multirow{2}{*}{_Streptococcus bovis_} & 12.5 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & 50 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & [34] \\ \hline \multirow{2}{*}{_Streptococcus circetus_} & 25 \(\mathrm{\SIUnitSymbolMicro g}\)/mL (EEP BA), & 100 \(\mathrm{\SIUnitSymbolMicro g}\)/mL (EEP BA), & \\  & 50 \(\mathrm{\SIUnitSymbolMicro g}\)/mL (EEP RS), & 200 \(\mathrm{\SIUnitSymbolMicro g}\)/mL (EEP RS), & [21] \\ \hline \multirow{2}{*}{_Streptococcus equinus_} & 12.5 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & 100 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & [34] \\ \hline \multirow{2}{*}{_Streptococcus gordonii_} & 1.25 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & [36] \\ \cline{2-4}  & 20 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & [62] \\ \cline{2-4}  & 12.5 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & [7] \\ \hline \multirow{2}{*}{_Streptococcus mitis biochar 1_} & 6.25–12.5 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & 50 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & [34] \\ \hline \multirow{6}{*}{_Streptococcus mutans_} & 50 \(\mathrm{\SIUnitSymbolMicro g}\)/mL (EEP BA), & 400 \(\mathrm{\SIUnitSymbolMicro g}\)/mL (EEP RS), & \\  & 100 \(\mathrm{\SIUnitSymbolMicro g}\)/mL (EEP RS), & 400 \(\mathrm{\SIUnitSymbolMicro g}\)/mL (EEP MG) & [21] \\ \cline{2-4}  & 400 \(\mathrm{\SIUnitSymbolMicro g}\)/mL (EEP MG) & \textgreater{}800 \(\mathrm{\SIUnitSymbolMicro g}\)/mL (EEP MG) & \\ \cline{2-4}  & 50–100 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & 800–1600 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & [59] \\ \cline{2-4}  & 2.5–10 mg/mL & [60] \\ \cline{2-4}  & 8.0 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & [61] \\ \cline{2-4}  & 200 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & [62] \\ \cline{2-4}  & 25–50 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & 200–400 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & [63] \\ \cline{2-4}  & 100\(\mathrm{\SIUnitSymbolMicro-}\)–200 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & 100\(\mathrm{\SIUnitSymbolMicro-}\)–200 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & [68] \\ \hline \multirow{2}{*}{_Streptococcus mitis_} & 0.17 mg/mL & [64] \\ \cline{2-4}  & 25–50 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & \textgreater{}1600 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & [69] \\ \cline{2-4}  & 35 \(\mathrm{\SIUnitSymbolMicro g}\)/mL & [65] \\ \hline \multirow{2}{*}{_Streptococcus mutans_} & 1.10 mg/mL & 9.01 mg/mL & [70] \\ \hline \hline \end{tabular}
\end{table}