# Acute and Repeated Toxicological Study of Anti-Inflammatory Herbal Formula, Yeosinsan, in Rats
## 3 Results
### Chronic oral Toxicity
#### 3.2.4 Hematological Test
\begin{tabular}{c c c c c c} \hline
**Dosage Group (mg\(\cdot\)kg\({}^{-1}\).d\({}^{-1}\))** & **0** & **500** & **1000** & **2000** \\ \hline TBW (g) & 546.1 \(\pm\) 79.76 & 543.6 \(\pm\) 42.11 & 551.0 \(\pm\) 49.88 & 565.0 \(\pm\) 42.30 \\ (ADRG) Adrenal glands (g) & 0.062 \(\pm\) 0.0096 & 0.063 \(\pm\) 0.0072 & 0.065 \(\pm\) 0.0110 & 0.064 \(\pm\) 0.0042 \\ (BRA) Brain (g) & 2.163 \(\pm\) 0.1352 & 2.214 \(\pm\) 0.0803 & 2.174 \(\pm\) 0.0824 & 2.214 \(\pm\) 0.0878 \\ (HT) Heart (g) & 1.706 \(\pm\) 0.2359 & 1.584 \(\pm\) 0.1162 & 1.641 \(\pm\) 0.1242 & 1.679 \(\pm\) 0.1135 \\ (KID) Kidneys (g) & 3.625 \(\pm\) 0.3945 & 3.958 \(\pm\) 0.3891 & 4.065 \(\pm\) 0.4607 & 4.280 \(\pm\) 0.4100 ** \\ (LIV) Liver (g) & 15.464 \(\pm\) 3.4509 & 15.848 \(\pm\) 2.1123 & 15.676 \(\pm\) 2.0249 & 16.580 \(\pm\) 1.3323 \\ (PITG) Pituitary glands (g) & 0.014 \(\pm\) 0.0033 & 0.015 \(\pm\) 0.0025 & 0.013 \(\pm\) 0.0016 & 0.013 \(\pm\) 0.0015 \\ (SPL) Splean (g) & 0.925 \(\pm\) 0.2494 & 0.903 \(\pm\) 0.1138 & 0.916 \(\pm\) 0.0730 & 1.068 \(\pm\) 0.2334 \\ (TES) Testes (g) & 3.517 \(\pm\) 0.3382 & 3.515 \(\pm\) 0.3207 & 3.516 \(\pm\) 0.2252 & 3.319 \(\pm\) 0.7046 \\ (THY) Thymus (g) & 0.478 \(\pm\) 0.1020 & 0.446 \(\pm\) 0.1158 & 0.449 \(\pm\) 0.0757 & 0.463 \(\pm\) 0.1338 \\ (SALG) Salivary glands (g) & 0.754 \(\pm\) 0.1519 & 0.714 \(\pm\) 0.0505 & 0.765 \(\pm\) 0.0780 & 0.783 \(\pm\) 0.0553 \\ (EPI) Epididymis (g) & 1.603 \(\pm\) 0.1721 & 1.610 \(\pm\) 0.1146 & 1.520 \(\pm\) 0.0698 & 1.453 \(\pm\) 0.2286 \\ (LUN) Lung (g) & 1.721 \(\pm\) 0.1855 & 1.772 \(\pm\) 0.1125 & 1.714 \(\pm\) 0.0862 & 1.836 \(\pm\) 0.0848 \\ (THPA) Thyroid and & 0.024 \(\pm\) 0.0058 & 0.028 \(\pm\) 0.0069 & 0.023 \(\pm\) 0.0028 & 0.025 \(\pm\) 0.0043 \\ parathyroid glands (g) & & & & & \\ (SVCG) Seminal vesicles & 1.983 \(\pm\) 0.4411 & 1.877 \(\pm\) 0.4002 & 1.805 \(\pm\) 0.2810 & 1.702 \(\pm\) 0.3097 \\ with coagulating gland & & & & & \\ (PROS) Prostate (g) & 0.606 \(\pm\) 0.1249 & 0.613 \(\pm\) 0.1515 & 0.581 \(\pm\) 0.1695 & 0.621 \(\pm\) 0.1494 \\ \hline TBW (g) & 309.4 \(\pm\) 26.33 & 300.5 \(\pm\) 20.04 & 292.2 \(\pm\) 19.22 & 290.4 \(\pm\) 29.27 \\ (ADRG) Adrenal glands (g) & 0.081 \(\pm\) 0.0062 & 0.082 \(\pm\) 0.0129 & 0.078 \(\pm\) 0.0084 & 0.077 \(\pm\) 0.0154 \\ (BRA) Brain (g) & 1.997 \(\pm\) 0.0653 & 2.019 \(\pm\) 0.0769 & 1.987 \(\pm\) 0.0634 & 1.969 \(\pm\) 0.0583 \\ (HT) Heart (g) & 1.046 \(\pm\) 0.0966 & 1.054 \(\pm\) 0.0735 & 0.974 \(\pm\) 0.0904 & 0.964 \(\pm\) 0.0835 \\ (KID) Kidneys (g) & 2.321 \(\pm\) 0.2309 & 2.303 \(\pm\) 0.1974 & 2.246 \(\pm\) 0.1541 & 2.297 \(\pm\) 0.2777 \\ (LIV) Liver (g) & 8.729 \(\pm\) 1.1196 & 8.443 \(\pm\) 0.7715 & 8.377 \(\pm\) 0.4921 & 8.611 \(\pm\) 0.9457 \\ (OVA) Ovaries (g) & 0.098 \(\pm\) 0.0249 & 0.095 \(\pm\) 0.0156 & 0.084 \(\pm\) 0.0139 & 0.093 \(\pm\) 0.0197 \\
**Female** & (PITG) Pituitary glands (g) & 0.021 \(\pm\) 0.0043 & 0.018 \(\pm\) 0.0032 & 0.019 \(\pm\) 0.0036 & 0.020 \(\pm\) 0.0041 \\ (SPL) Splean (g) & 0.574 \(\pm\) 0.0379 & 0.611 \(\pm\) 0.1084 & 0.657 \(\pm\) 0.0855 & 0.661 \(\pm\) 0.1035 \\ (THY) Thymus (g) & 0.343 \(\pm\) 0.0581 & 0.329 \(\pm\) 0.0683 & 0.331 \(\pm\) 0.0479 & 0.344 \(\pm\) 0.0899 \\ (SALG) Salivary glands (g) & 0.466 \(\pm\) 0.0690 & 0.458 \(\pm\) 0.0476 & 0.449 \(\pm\) 0.0369 & 0.471 \(\pm\) 0.0413 \\ (LUN) Lung (g) & 1.347 \(\pm\) 0.1355 & 1.346 \(\pm\) 0.0768 & 1.329 \(\pm\) 0.0896 & 1.344 \(\pm\) 0.1263 \\ (THPA) Thyroid and & 0.019 \(\pm\) 0.0039 & 0.020 \(\pm\) 0.0037 & 0.019 \(\pm\) 0.0025 & 0.019 \(\pm\) 0.0036 \\ (UTEC) Uterus/cervix & 0.725 \(\pm\) 0.1570 & 0.903 \(\pm\) 0.4507 & 0.741 \(\pm\) 0.3030 & 0.741 \(\pm\) 0.3344 \\ \hline \end{tabular}  Data are expressed as the mean \(\pm\) SD, n = 10 animals per group.