## 3 Materials and Methods
### Chemical Syntheses
#### 3.2.5 Preparation of Phenyl(4-benzyloxy)-7-morpholinobenzo[_d_]thiazol-2-yl)carbamate (6)
HRMS \(m/z\): [M + H]\({}^{+}\) calcd: 393.1591; found: 393.1588. Preparation of Tetrabutylammonium 2-(4-Hydroxy-4-methylpiperidine-1-carboxamido)-7-morpholinobenzo[\(d\)]thiazol-4-olate (8a)  
(According to a Modification of the Procedure in [27])  
Tetrabutylammonium hydroxide (1 m solution in MeOH, 100 \(\mu\)L, 100 \(\mu\)mol, 1 equiv) was added dropwise to a vortexed suspension of **8** (47 mg, 120 \(\mu\)mol, 1.2 equiv) in MeOH (2.4 mL, 20 \(\mu\)L/ \(\mu\)mol 8, \(c\) = 0.05 M). The mixture was vortexed for 1 min and then centrifuged at 20,000 rpm for 1 min to remove unreacted **8**. The clear yellow supernatant was recovered with a pipette and MeOH evaporated under reduced pressure. The product was dried using careful heating (<40 \({}^{\circ}\)C) under reduced pressure to afford the title compound (58 mg, 92% yield based on TBAOH) as a greenish semi-solid. \({}^{1}\)H-NMR (400 MHz, CDCl\({}_{3}\)) \(\delta\) = 0.90 (t, \(J\) = 7.3 Hz, 12H, TBAC\({}^{4}H_{3}\)), 1.21-1.30 (m, 1H, TBAC\({}^{3}H_{2}\) + CH\({}_{3}\)), 1.34-1.42 (m, 8H, TBAC\({}^{2}H_{2}\)), 1.57 (t, \(J\) = 5.5 Hz, 4H, Pip-C\({}^{3}H_{2}\) + Pip-C\({}^{5}H_{2}\)), 3.08 (s\({}_{\rm br}\), 4H, CH\({}_{2}\)NCH\({}_{2}\)), 2.87-2.91 (m, 8H, TBAC\({}^{1}H_{2}\)), 3.46-3.50 (m, 3H, 0.5 Pip-C\({}^{2}H_{2}\) + 0.5 Pip-C\({}^{6}H_{2}\) + OH), 3.82 (t, 4H, \(J\) = 4.3 Hz, CH\({}_{2}\)OCH\({}_{2}\)), 4.05 (s\({}_{\rm br}\), 2H, 0.5 Pip-C\({}^{2}H_{2}\) + 0.5 Pip-C\({}^{6}H_{2}\)), 6.38 (d, \(J\) = 8.2 Hz, 1H, \(H^{6}\)), 6.88 (d, \(J\) = 8.2 Hz, 1H, \(H^{5}\)). \({}^{13}\)C-NMR (101 MHz, CDCl\({}_{3}\)) \(\delta\) = 13.7 (TBAC\({}^{4}\)), 19.5 (TBAC\({}^{3}\)), 23.8 (TBAC\({}^{2}\)),29.6 (CH\({}_{3}\)), 39.1 (Pip-C\({}^{3,5}\)), 40.1 (Pip-C\({}^{2,6}\)), 51.5 (CNC), 58.3 (TBAC\({}^{1}\)), 67.6 (COC), 68.7 (Pip-C\({}^{4}\)), 109.6 (\(C^{6}\)), 111.9 (\(C^{5}\)), 124.7 (\(C^{7a}\)), 137.8 (C\({}^{3a}\)), 139.5 (\(C^{7}\)), 142.2 (\(C^{4}\)), 162.3 (C=O), 170.8 (\(C^{2}\)). C\({}_{34}\)H\({}_{59}\)N\({}_{5}\)O4S, 633.92 g/mol. MS not possible due to decomposition. 2.9 Preparation of (\(N\)-(4-(Benzyloxy)-7-morpholinoobenz[\(d\)]thiazol-2-yl)-4-hydroxy-4-methylpiperidine-1-carboxamido)methyl Pivalate (9)  
(100,000)(000,000)(000,000)(000,000)(000,000)(000,000)(00,000)(00,000)(00,000)(00,000)(00,000)(00,0000)(000,000)(00,000)(000,000)(000,000)(00,000)(00,000)(000,000)(000,000)(000,000)(000,000)(000,000)(000,000)(000,000)(000,000)(000,000)(000,000)(000,0000)(000,0000)(000,000)(000,0000)(000,000)(0000,000)(00  
stirred at 60 \({}^{\circ}\)C for 30 min and a solution of chloromethyl1 pivalate (252 \(\upmu\)L, 1.3 mmol) in anhydrous DMF (500 \(\upmu\)L) was slowly added. After stirring for another 1 h at 60 \({}^{\circ}\)C (TLC: ethyl acetate/hexane, 70/30, R\({}_{\textrm{fUrea}}\) 0.37, R\({}_{\textrm{fPom-urea}}\) 0.44), the reaction mixture was cooled to ambient temperature and poured into a combination of ice/water (150 mL). The mixture was stirred for 0.5 h and cooled overnight. The resulting precipitate was collected via filtration and treated with boiling ethyl acetate (\(\pm\) 25 mL). After cooling to ambient temperature, the solid was recovered by filtration and dried at 60 \({}^{\circ}\)C to afford the title compound (555 mg, 91%) as colorless crystals, mp >300 \({}^{\circ}\)C (ethyl acetate). \({}^{1}\)H-NMR (400 MHz, DMSO-\(d_{6}\)) 8 1.03 (s, 9H, Pom-CH\({}_{3}\)), 1.13 (s, 3H, CH\({}_{3}\)), 1.27-1.53 (m, 4H, Pip-C\({}^{3}\)\(H_{2}\) + Pip-C\({}^{5}\)\(H_{2}\)), 2.95 (t, 4H, \(J\) = 4.5 Hz, CH\({}_{2}\)NCH\({}_{2}\)), 3.12-3.28 (m, 2H, 0.5 Pip-C\({}^{2}\)\(H_{2}\) + 0.5 Pip-C\({}^{5}\)\(H_{2}\)), 3.76 (t, 4H, \(J\) = 4.5 Hz, CH\({}_{2}\)OCH\({}_{2}\)), 3.84 + 4.04 (2\(\textrm{s}_{\textrm{br}}\), 2H, 0.5 Pip-C\({}^{2}\)\(H_{2}\) + 0.5 PipC\({}^{6}\)\(H_{2}\)), 4.36 (8\(\textrm{s}_{\textrm{br}}\), 1H, OH), 5.22 (s, 2H, Bn-CH\({}_{2}\)), 6.43 (8\(\textrm{s}_{\textrm{br}}\), 2H, Pom-CH\({}_{2}\)), 6.94 (d, 1H, \(J\) = 8.5 Hz, \(H^{6}\)), 7.17 (d, 1H, \(J\) = 8.5 Hz, \(H^{5}\)), 7.30-7.50 (m, 5H, C\({}_{6}\)\(H_{5}\)).