## 1 Introduction  
In recent years, we have witnessed continuous discussions about the IoT (Internet of Things) concept, which involves the connection of various objects that surround us in our everyday life to the Internet. The main purpose of the IoT concept is closely related to the smart city topic, enabling an increase in quality of life by contributing to the efficient use of resources and environment protection. IoT technologies are sufficiently enhanced to enable the development of integrated solutions for the challenges humankind is facing today. All this knowledge and technological progress does not seem to have prepared us enough for the current context of the pandemic we are experiencing. Considering the pandemic context, all of these IoT devices that surround us in our daily life are powerless in the face of the spread of the SARS-CoV2 virus infection. Until the start of the pandemic, there was not a strong connection between the IoT and the healthcare industry. This aspect must change and allow for the integration of healthcare services in current existing IoT infrastructure; this change is also forced by the current pandemic situation. Thus, it is our responsibility, as a research community, to develop new systems and find solutions to current problems. The COVID-19 disease, which is a severe acute respiratory syndrome generated by the SARS-CoV2 virus, is an ongoing pandemic [1]. This has led to an immense public health concern in the international community, as the World Health Organization (WHO)has stated, that the outbreak was a public health emergency. International concern led to declaring the COVID-19 outbreak a global pandemic on the 11 th of March 2020 [2]. Since then, things have progressed quite rapidly, with the number of infections growing exponentially. Globally, as of 8 th December 2021, there have been approximately 300 million confirmed cases of COVID-19, including more than 5 million deaths, reported to WHO [3]. In this paper, we present the design, development, and implementation of an integrated system for COVID-19 illness management that is associated with the SARS-CoV2 virus infection. The urgent need for this system is related to the fact that the architecture can enable local authorities to reduce the pressure on the medical system by integrating telemedicine facilities allowing for remote monitoring of patients. Thus, the health status of patients is closely monitored by medical staff and depending on the current load on the medical system, suspect patients, quarantine, isolated patients and even mild cases can be remotely monitored while at home. The proposed system integrates an IoT multi-sensor approach that offers the possibility of monitoring different vital signs of the patient. The patient-monitoring node is integrated in a wearable device that is easy to wear and fully reconfigurable, allowing further development by integrating other sensor types. Thus, the proposed system can be seen as a powerful IoT multi-sensor platform. The implemented and tested novel architecture allows for the integration of a high number of wearable devices, in an effective and cost-efficient manner. The system also monitors the persons that are quarantined due to infection or suspicion of infection with the SARS-CoV2 virus. The paper is organized as follows: first, a brief introduction related to the state-of-the-art technology, followed by Section 2, where the main IoT challenges regarding the SARS-CoV2 pandemic are presented. The IoT communication protocols, and challenges for pandemic control are discussed in Section 3. In Section 4, the IoT wearable multi-sensor architecture for remote patient monitoring is presented and discussed in detail. The final section of the paper is represented by the conclusions and the overall performance discussion of the system.