## Appendix A
\begin{table}
\begin{tabular}{p{113.8 pt} p{113.8 pt} p{113.8 pt} p{113.8 pt}} \hline \hline
**Plant Name** & **Active Compounds** & **Plants Parts** & **Pharmacological Properties** & **References** \\ \hline \multirow{9}{*}{_H. cordata_} & Canthaxanthin, Cholester-4,14-dien-15,20-diol-3,16-dione, Dihydrocleastrol, Fluoromethane 17-acetate, Isoquercitrin, Kanzonol V, Naltrindole, Pirenperone, Pogdelanamycin, Quercitrin, Rhodoxanthin, Sesamin, Stigmastane-3,6-dione, Usamabarensin & Cough, pneumonia, bronchitis, dysentery, dropsy, leukorkne, uveitis, coczena, herpes simplex, acne, chronic sinusitis, stomach ulcer, infection, control wrinkle, chopped skin, septic, febrileuge, heatstroke, malaria, lung disorder, tonsillitis, skin ulcer, diarrhea, dysentery arthritis, appendicitis, snake bite, stomach disorder, sinusitis, heart disorders, severe acute respiratory Syndrome (SARS), chikungunya, herpes simplex viruses, dengue virus serotype 2 (DEN-2), influenza neuroaminidase, Sesamin, Migmastane-3,6-dione, Usamabarensin & Coughs, colds, asthma, respiratory and digestive disorders, sinus, ambulatory effects of cell membrane permeability, acts against food borne gram-positive bacteria, promotion of Go/G1 cell cycle arrest, induction of apoptosis, anti-diabetic antifungal, and acts effectively against SARS-CoV-2. & [70, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109] \\ \cline{2-3}  & Chlorogenic acid, Isoquercitrin, Rutin, Beta-Sitosterol, Stigmastrelo & Leaves & Tiredness and muscle fatigue, diarrhea, coughing, muscle pain, anti-diabetic, wound, hypertension, drug addiction, anti-inflammation, antinociceptive, anti-oxidant, antimicrobial activity, and reduction of muscle pain against SARS-CoV-2. & [79, 110, 111, 112, 113, 114, 115] \\ \hline \multicolumn{3}{p{113.8 pt}}{ Kabasura kudineer} & \multirow{3}{*}{Root} & Respiratory disease, fever, anti-inflammatory, anticancer, antinociceptive, liver disorders, anti-allergic, and acts as anti-oxidant. & [63, 64, 116, 117] \\ \cline{2-3}  & Acteoside, Clerodermic acid, Verbascoside & & Respiratory disease, fever, anti-inflammatory, anticancer, antinociceptive, liver disorders, anti-allergic, and acts as anti-oxidant. & [63, 64, 116, 117] \\ \hline \multirow{9}{*}{_H. auriculata_} & \multirow{3}{*}{Apigenin 7-O-glucoside} & \multirow{3}{*}{Root} & Anasarca, urinoignentifal tract disorder, hyperlipis, vesical calculi, flatulence, diarrhea, leukorkne, gonorrhea, gastrointestinal disorder, anti-tumor, arthritis, painful tricutri, menorrhasia, and treats blood infection. & [63, 64, 118, 119] \\ \cline{2-3}  & & & Immuno-modulation, pneumonia, asthma, cough, swelling lungs, colic, constipation, tetanus, anthrax, px fracture, antipsychoticsmodic, and antipyretic activity. & [63, 64, 75, 120, 121] \\ \cline{2-3}  & & & Pneumonia, constipation, skin diseases, fever, asthma, bronchitis, inflammation, anaemia, dropsy, cough, urinary diseases, jaundice, improves insulin secretion, hypolippidemic, adaptogenic, anticancer, and hepatoprotective activity. & [63, 64, 122, 123, 124, 125] \\ \cline{2-3}  & & & Colds, sinusitis, influenza, immunohistochemical, anti-viral against hepatitis B, HIV, and respiratory syncytial virus. & [63, 64, 126, 127] \\ \cline{2-3}  & & & Anti-inflammatory, anti-oxidant, antimicrobial, antidiabetic, hepatoprotective, photo-protective, uterine stimulant, antispric, antipyretic, and immunosuppressiveulant activity. & [63, 64, 128, 129] \\ \cline{2-3}  & & & High fever, inflammation, wounds, eczena, scabies, skin infections, bronchitis pain, and antimicrobial activity. & [63, 64, 121, 130] \\ \hline \hline \end{tabular}
\end{table} 
Table 3: The pharmacological activity of the active compounds against S-Protein (mutated NTD and RBD) of Indian delta variant B.1.617.2. We finally identified the compounds acteoside and verbascoside from _C. serratum_ as acting effectively against the mutated NTD (Figure 4D-I,K,L).