## 4 Discussion
### Skin Aging  
[PERSON] et al. [28] introduce the Mimicking Intraoral Mucosal Tissues (MIMT) concept in orofacial aesthetics. This concept aims to replicate the characteristics and properties of oral mucosal tissues in dental procedures and restoration. By using materials and techniques that mimic the natural tissues of the mouth, dental professionals can achieve more natural aesthetic results, where restoration and prosthetics blend seamlessly with the surrounding tissues. Mimicking the characteristics of intraoral tissues, such as texture, color, and elasticity, the materials used in dental procedures can provide greater comfort and adaptation for patients. In addition, the authors suggest that incorporating dermal HA fillers, such as those in the Restylane(r) product line, along with the MIMT concept, can provide natural and long-lasting results in orofacial rejuvenation, as they consider the unique qualities of intraoral mucosal tissues.  
[PERSON] [25], meanwhile, proposes different aesthetic techniques that use botulinum toxin and/or dermal fillers in the oral and maxillofacial area. The author analyzes the relevant anatomy and physiology of the muscles and skin of the region and discusses the various aesthetic approaches in which botulinum toxin and dermal fillers can be used. The study highlights that botulinum toxin and HA are safe and effective options for treating the oral and maxillofacial area and can produce optimal aesthetic results for patients.  
[PERSON] et al. [29] discuss the suggestions for using HA in different areas of the period region, lips, and jaw and describe injection techniques to achieve a more youthful and balanced facial appearance. In addition, the article highlights the possible side effects of HA, such as edema, hematomas, infection, and vascular complications, so recommendations are provided to minimize these risks and ensure safe and effective application, as reported in other research studies [50; 51; 52; 53; 54]. The authors also highlight that facial filler with HA has been established as an effective and safe intervention because it is a biocompatible substance that occurs naturally in the body, which minimizes the risk of adverse reactions and increases patient acceptance of the treatment, as reported by other researchers [55; 53; 56; 57].  
According to [PERSON] et al. [11], changes in the period region that occur with aging are evaluated using anthropometric measurements. The sample consisted of seventy individuals of different ages and gender, and age-related changes in period morphology were identified. These changes included decreased lip height and thickness, increased philtrum depth, decreased chin projection, and increased vertical distance between the lower lip and chin. The study aimed to provide a better understanding of how the period region changes with age and its clinical implications for aesthetic and reconstructive procedures in this area. The authors also discussed their findings' clinical implications,suggesting that dermal fillers, fat grafting, or surgical procedures could restore a youthful appearance in the period region.  
The research studies by [PERSON] et al. [58], [PERSON] et al. [59], [PERSON] et al. [60], and [PERSON] et al. [61] also address different aspects of skin aging and the aesthetic approaches used for facial rejuvenation, adding evidence that HA and botulinum toxin are safe and effective options in dentistry for facial rejuvenation, thus supporting the abovementioned findings. These fillers can fill wrinkles, increase skin hydration, improve elasticity, and provide a more youthful and balanced appearance. The studies report the importance of recognizing the anatomy and physiology of the oral and maxillofacial region and the appropriate application techniques to achieve optimal aesthetic results. Moreover, it is emphasized that using these fillers in combination with other procedures can potentiate the effects and achieve satisfactory patient results.