report the first case of steroid-refractory relapsed multiple sclerosis (MS) on Fingolimod (FTY), treated effectively by this technique, in a 37-year-old woman. Their findings were: First, the steroid-refractory relapsed MS on FTY, however serious, can be treated with DFPP; second, given the good clinical improvement due to the DFPP-induced neuroinflammationlamatory components removal, this clinical condition can be associated with a Lucchinetti pattern II of demyelination [20]. Since early 2020, COVID-19, a consequence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly affected millions of people worldwide. The SARS-CoV-2 infection in children appears to be an unusual event. Due to the promising effects of mesenchymal stem cells (MSCs) in the treatment of various diseases, [PERSON] et al. hypothesis aimed to focus on the auxiliary role of MSCs to reduce inflammatory processes of acute respiratory infections caused by the 2019 novel coronavirus (COVID-19) [21]. Coronary computed tomography angiography (CCTA) is a first-line non-invasive imaging modality for the detection of coronary atherosclerosis. Computational modeling with lipidomics analysis can be used for the prediction of coronary atherosclerotic plaque progression. In the study proposed by [PERSON] et al., a multi-parametric predictive model, including traditional risk factors, plasma lipids, 3D imaging parameters, and computational data, demonstrated 88% accuracy to predict site-specific plaque progression, outperforming current computational models [22]. Currently, little published research exists evaluating the stability of commercial vitamin A products during storage. Therefore, in a further study, [PERSON] et al. aimed to determine the storage stability of five commercial sources of vitamin A in premix, and provide a guideline for product formulation and application [23]. Alternative treatment strategies are necessary to reduce the severity of glaucoma, a group of eye conditions that progressively damage the optic nerve and impair vision. The aim of [PERSON] et al. review was to gain insight into potentially exploitable molecular mechanisms to slow down the death of retinal ganglion cells (RGCs), a fundamental element in the pathophysiology of all forms of glaucoma, and to stimulate adult optic nerve repair. For this purpose, they focus analysis on both visible and far-red to near-infrared light photobiomodulation (PBM) as phototherapeutic agents, which were recently proposed in RGCs, and on the nerve lamina region neural progenitor cell (ONLR-NPC) niche [24]. It is well-known that tooth brushing might be associated with the development of oral soft tissue lesions. There is currently a continuing increase in the demand for new safety and performing materials in daily homecare oral hygiene, including soft and extra-soft toothbrush bristles that tend to be safer. An original and featured study presented in the Special Issue, aimed to compare the efficacy of plaque control and the potential effects on gingival health of two different toothbrush bristle models. From the comparison between data and the literature studies, the authors can state that the material and shape of the bristles of the toothbrush affect the home practice of oral hygiene. The proposed thermoplastic elastomer (TPE) bristles reduce the presence of plaque formation and gingival bleeding, oral soft tissue injuries acquired during homecare oral hygiene [25]. Apples are the most popular fruits grown in Polish orchards. In order to obtain the best quality fruit, it is necessary to improve plantation maintenance, fruit harvesting, and processing. Given that many fruits are exposed to external factors, including forces that adversely affect their structure--causing them to crack, bruise, or crush--it is necessary to provide conditions that do not adversely affect their quality. Therefore, the aim of [PERSON] et al. article was to develop a simplified model of an apple that could be tested under different loads using the finite element method [26].