## Potential Health Benefits of Fruits and Vegetables II
This study aimed to investigate the chemical composition of safflower and its antidepressant-like effects using a hot water extract in male mice. The mechanism of action was explored through the transcriptomic analysis of the hippocampus. GC-MS analysis revealed that the hot water extract contained a significant amount of oleamide, which is known for its activity. Neuro-behavioral tests showed that safflower treatment significantly reduced immobility time in the TST and FST, and improved performance in the YMSAT compared to the control group. RNA-seq analysis identified differential gene expression in several genes related to MDD regulation. Overall, this study demonstrated the antidepressant-like effects of safflower hot water extract, attributed to its bioactive ingredient oleamide, as evidenced by behavioral changes and gene expression patterns [10]. The human in vivo trial was conducted by [PERSON] et al. (2022) and investigated dyslipidemia, which is a risk factor for cardiovascular disease and a leading cause of global mortality. Lipid-lowering drugs can have side effects; therefore, consuming vegetables and fruits with probiotics is a potential alternative to positively influence plasma lipid profiles. This study aimed to investigate the effects of consuming vegetable and fruit juice (VFJ) with and without probiotic _Lactobacillus paracasei_ on various parameters in dyslipidemic patients over 30 days. The probiotic group showed significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, triglycerides, and the TG/high-density lipoprotein cholesterol ratio compared to the placebo group. Additionally, the probiotic group had higher levels of high-density lipoprotein cholesterol. The probiotic group also demonstrated reduced levels of malondialdehydedehyde (a marker of lipid peroxidation), increased levels of oxidative stress enzymes (catalase and glutathione peroxidase) in plasma, and increased bile acid levels in feces. These findings suggest that VFJ enriched with probiotic _L. paracasei_ may serve as an alternative approach for preventing dyslipidemia in patients who have not yet started other medication, providing a primary intervention method [11]. The last two contributions to this collection are RVs, which provide a detailed overview of two different central topics for the evaluation of the potential health benefits of fruits and vegetables: the role of different vegetal-derived bioactive compounds in the modulation of colorectal cancer, and the main characteristics and health effects of berry fruit volatiles. According to [PERSON] et al. (2023), colorectal cancer is a significant cause of illness and death, and drug resistance poses a major challenge in its treatment. Bioactive compounds derived from vegetables are being investigated as a potential strategy to enhance antitumor therapies by targeting key pathways involved in carcinogenesis and multidrug resistance. In both laboratory and animal studies, these compounds have shown the ability to reduce drug resistance and enhance therapeutic effectiveness when combined with cytotoxic drugs. This review aims to summarize the existing scientific literature on the antitumor and chemo-sensitizing properties of vegetable-derived biomolecules such as polyphenols, flavonoids, and terpen. These compounds have the potential to offer promising prospects for improving the treatment of colorectal cancer [12]. In the second RV, [PERSON] et al. (2022) state that volatile compounds give fruits their aroma, and berries are rich in these compounds, including esters, alcohols, terpenoids, and more. This review focuses on the volatile compounds in strawberries, blueberries, raspberries, blackberries, and cranberries. These compounds have various health benefits, such as anti-inflammatory, anti-cancer, anti-obesity, and anti-diabetic effects. Monoterpenes, like linalool, limonene, and geraniol, are particularly important in berry aromas and offer several health benefits.