sentence: Therefore , the inhibition of Ubc13 by small compounds could limit the response to viral infections mediated through this pathway.Regarding the role of Ubc13 and K63 polyubiquitylation in DNA damage response , the very high similarity of Uev2 ( Mms2 ) to Uev1 , and the computed interaction of compound Ia on the hydrophobic pocket of Ubc13 , allows to predict with sufficient confidence that this compound should disrupt also the interaction of Uev2 ( Mms2 ) with Ubc13 .