sentence: This study demonstrated , for the first time , that treatment with oltipraz inhibited allodynia , hyperalgesia , and depressive-like behaviors induced by sciatic nerve injury by inhibiting microglial activation , avoiding the up-regulation of PI3K / p-Akt and p-IKB α , and activating the antioxidant enzymes HO-1 and NQO1 triggered by Nrf2 in the spinal cord , hippocampus , and / or prefrontal cortex.The management of chronic neuropathic pain is a serious clinical problem due to the reduced efficacy of conventional treatments [ 47,48 ] .