sentence: Since high ‐ risk disease ( which includes men with HGPC ) accounts for approximately 15 % of new localized PC diagnoses , it is important to attempt sub ‐ stratification of these men in order to identify those most likely to benefit from upfront combinatorial therapy and reduce morbidity associated with adverse effects from chemotherapy or other adjuvant treatments 19 , 20 , 21.In accordance with previous studies , we found few clinical or pathological variables associated with progression to CRPC , metastases or death from PC in the analysis of this HGPC cohort 9 .