sentence: Nonetheless , both studies did not demonstrate an improvement of VIPN after vincristine dose reduction.Here , we present a large “ real world ” cohort of patients with de novo DLBCL treated with R-CHOP in 21-day cycles showing a VIPN rate of 32 % ( 199/605 ) which is in agreement with published large prospective trials [ 4 , 6 – 9 ] .