sentence: Moreover , viral assembly appears to be cell-type dependent ( Ono and Freed , 2004 ) , and virions are assembled and released in viral-containing compartments ( VCCs ) in macrophages , beyond the reach of antivirals or antibodies , and from where cell-to-cell infection can occur unhindered ( Pelchen-Matthews et al ., 2003 ; Sharova et al ., 2005 ; Gousset et al ., 2008 ; Groot et al ., 2008 ; Chu et al ., 2012 ; Inlora et al ., 2016 ) .