sentence: Alternatively , RNA incorporation may reflect a mechanism that minimizes the deleterious consequences of collisions between transcription and replication complexes ( 30 ) , by inhibiting transcription on replicating molecules ( 31 ) , or restraining the replisome.The in organello mtDNA replication system provides a test-bed to study the role of proteins implicated in mtDNA replication , such as the mitochondrial RNA polymerase POLRMT ( 32 ) , mitochondrial transcription factors ( 33 ) , members of the mTERF family ( 34 ) and the DNA helicase Twinkle ( C10orf2 ) .