sentence: The effects of oltipraz on the nociceptive responses and depressive-like behaviors that accompany chronic pain and on microglial activation and subsequent induced pain signaling pathways in the spinal and supraspinal regions of sciatic nerve-injured animals have not yet been evaluated.Here , we investigated the antinociceptive and antidepressant properties of oltipraz in a mouse model of neuropathic pain induced by the chronic constriction of the sciatic nerve ( CCI ) .