sentence: The expressed p53 gene appears to exert its antitumor activities by triggering apoptotic pathways , activating immune response factors such as natural killer cells , inhibiting DNA repair and antiapoptosis functions , and blocking the transcription of survival signals.In a Phase I clinical trial in 2003 , Gendicine was used for treating 12 patients with advanced laryngeal cancer , with an average clinical course of 41 months.36 There was no patient relapse for more than 5 years after Gendicine treatment .