sentence: These conjectures invite computer simulations and cell culture experiments and may provide deeper understanding of the regulation defects in cancer.The unusually high NEC correlations of IRF6 ( r = 0.93 ) , OVOL1 ( r = 0.83 ) , OVOL2 ( r = 0.75 ) , ST14 / matriptase ( r = 0.89 ) , PRSS8 / prostasin ( r = 0.83 ) , and SPINT1 / Hai1 ( r = 0.88 ) are striking and indicate that these proliferation / differentiation control genes work together specifically in epithelial tumor cell lines.Finally , it may be noted that expression of many of these NEC-correlated genes is associated with relatively low carcinoma aggressiveness .