sentence: We found that young never ‐ smoker patients with LUAD harbored a unique pattern of germline mutations in cancer predisposition genes , including BPIFB1 ( rs6141383 , p.V284M ) , CHD4 ( rs74790047 , p.D140E ) , PARP1 ( rs3219145 , p.K940R ) , NUDT1 ( rs4866 , p.V83M ) , RAD52 ( rs4987207 , p.S346 * ) and MFI2 ( rs17129219 , p.A559T ) .