sentence: Microparticles , heterogeneous extracellular vesicles that include exosomes , nanoparticles , and shedding vesicles , are not only a prognostic marker of atherosclerosis acceleration and clinical presentation of familial hypercholesterolemia but also therapeutic agents for CAD ( Boulanger et al. 2017 ; Loyer et al. 2014 ; Suades et al. 2019 ) .