sentence: These results are consistent with the antinociceptive effects of other Nrf2 inducers , including sulforaphane and plumbagin , and of several antioxidant compounds in animals with neuropathic pain induced by nerve injury , diabetes , or oxaliplatin [ 22,24,30,49,50,51,52 ] , further demonstrating the antinociceptive properties of oltipraz under the condition of chronic neuropathic pain.The participation of spinal microglial cells in the development of neuropathic pain via the activation of several intracellular paths , such as PI3K - , NF - κ B - , and MAPK-related pathways , has been established .