sentence: Consideration in this regard should take into account that a ) studies rather diagnose haploinsufficiency forms of ADID because of truncating variants and that pathogenic loss-of-function missense variants in addition to gain-of-function variants would still make up a significant number of undiagnosed cases [ 1 ] , b ) ARID is more heterogeneous and despite a large number of known genes , most ( two thirds to three quarters ) ARID genes have not yet been identified , and c ) deciphering noncoding variants and multifactorial inheritance in ID is still far behind .