sentence: We further provide initial characterisation of the functional role of ANKS3 in vivo in the regulation of the expression of Anks6 and genes encoding proteins involved in vasopressin-driven water reabsorption ( Vit32 , aquaporins 1 , 2 and 3 ) , in apoptotic and proliferative signaling pathways ( caspases 3 and 9 , p53 ) and in cilium structure ( Cep290 , Gli2 , Nek8 and Nphp1 , 2 , 4 and 5 ) in the mouse kidney .