sentence: The others are SEC61B which is involved in the translocations of proteins to the ER , ASB9 which is involved in the ubiquitination pathway , PLCXD3 which has signal transducer and phosphoric diester hydrolase activity , UCHL1 which is a ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins and GSTM2 which is involved in the detoxification of electrophilic compounds and products of oxidative stress , by conjugation with glutathione.In the AAB + cases the most significantly upregulated protein is REG1B which is also upregulated in T1D cases .