sentence: Plaque formation appears to be a continuing process tightly associated with synaptic degeneration , with dendritic spine loss and axonal terminal degeneration / dystrophy at the lesion sites ( Gonatas et al ., 1967 ; Masliah et al ., 1991 ; Ferrer et al ., 1998 ; Adalbert and Coleman , 2013 ; Yan et al ., 2014 ; Herms and Dorostkar , 2016 ; Sadleir et al ., 2016 ) .