sentence: Mislocalized proteins ubiquitinated by the Asi complex are subsequently extracted from the INM by the soluble ATPase Cdc48 ( p97 in mammals ) in complex with its cofactors Npl4 and Ufd1 and handed to the proteasome for degradation ( Bays et al ., 2001 , Foresti et al ., 2014 , Jarosch et al ., 2002 , Khmelinskii et al ., 2014 , Rabinovich et al ., 2002 , Ye et al ., 2001 ) .