sentence: NOX-A12 is an L-configured aptamer ( spiegelmer ) 48 that binds CXCL12 with high affinity and specificity across various species , including humans.49 Of note , NOX-A12 not only directly binds and inhibits but also detaches the cell-surface bound CXCL12 , which also diminishes a CXCL12 gradient throughout the tissue.50 NOX-A12 inhibits the interaction of CXCL12 with both its receptors : CXCR4 and CXCR7 .