sentence: Additionally , work has revealed that determination of the active strand in the post-Dicer-processed dsRNA is directly related to the stability of dsRNA ends ( Khvorova et al ., 2003 ; Schwarz et al ., 2003 ) ; more specifically , the strand with a less-stable base pairing of the two to four nucleotides at the 5 ′ end of the duplex tends to associate with the RISC and becomes the active miRNA which can be trafficked to its mRNA target to effectively post-transcriptionally silence that target ( Schwarz et al ., 2003 ) .