sentence: We recently established a positive role for cyclin G ( cycG ) in the regulation of growth and metabolism in Drosophila ( Fig. 1A ) .16 In order to analyze the function of Drosophila cycG during development , we generated 2 independent cycG null mutant alleles using both , ends-in and ends-out homologous recombination techniques for the knock out.17 ,18 The resulting mutant flies are homozygous viable , although developmentally delayed and underrepresented when compared to the number of heterozygous siblings.16 Moreover , females are sterile and lay ventralized eggs , as a result from a defect in recombination repair.19 ,20 Notably , cycG mutant flies and larvae are underweight , show signs of starvation and have a disturbed fat metabolism ( Fig. 1A ) .