sentence: Interestingly , RDR2 knock-out plants are not hypersusceptible against geminiviruses and vsiRNA profiles against the geminivirus cabbage leaf curl virus ( CaLCuV ) are not remarkably changed in RDR1 ,2,6 triple knock out plants compared with wild type plants ( Raja et al ., 2008 ; Aregger et al ., 2012 ) .