sentence: These interactions may feed into the pathway where mutations of the APC gene , common in pre-cancerous colonic polyps , abrogate the degradation of CTNNB1.NEC-correlated genes may link between cell-cell junctions and cytoskeleton : CGN / cingulin ( r = 0.80 ) can bind both tight junctions and F-actin ; CAMSAP3 ( r = 0.76 ) links adherens junctions to microtubules ; DSP / desmoplakin ( r = 0.62 ) links desmosomes to the intermediate filament keratins KRT8 , 18 , and 19 ( r = 0.63 , 0.63 , 0.59 ) ( Figure 14 ) .