sentence: Levels of MAP3K5 and MAP3K9 transcripts did not correlate with mutation status ( Supplementary Fig. 5 and Supplementary Table 7 ) , suggesting the mutations do not grossly affect mRNA expression and stability.We analysed the available three-dimensional protein structures to provide insight to whether the MAP3K5 or MAP3K9 mutations may have an effect on structure or kinase activity ( Fig. 2 ) .