sentence: Accumulative evidence has demonstrated that MSCs are capable of self-renewal , multipotent differentiation ( Minguell et al ., 2001 ; Munmun and Witt-Enderby 2021 ) , regulating immune and inflammatory responses ( Uccelli et al ., 2008 ) , and suppressing apoptosis and oxidative stress ( Tsubokawa et al ., 2010 ) .