sentence: Furthermore , crystal structures of association between the proteins ANKS6 and ANKS3 suggest physical binding between their SAM domains [ 10 ] , providing that they are co-expressed in the same cells , which we were able to confirm here through analysis of the mutation R823W in the ANKS6 SAM domain that prevents ANKS3-ANKS6 binding , and through evidence of their co-localisation in kidney tubules and glomeruli.Proteins of the ANKS family are structurally related molecules characterized by the presence of both ankyrin repeats and SAM domain .