sentence: We first designed a variant , named OaAEP2_select where , given the importance of the MLA , we extended the substitutions of residues into OaAEP2 to include OaAEP1 residues Asp295 , Lys296 , Ile 298 , His300 , and Ala301 ( OaAEP1 numbering ) ( Fig. 6b , Supplementary Fig. 4 ) .