sentence: Unrepaired damage to mtDNA leading to mutations and energetic dysfunction has been linked to several debilitating diseases , such as diabetes mellitus , neoplasias , and Parkinson 's and Alzheimer 's diseases.When injected intra-articularly in mice , purified mtDNA induced arthritis whereas nDNA from the same cells did not ( LV Collins , S Hajizadeh , E Holme , I-M Jonsson , A Tarkowski , unpublished work ) .