sentence: In this context , the top six highly significant targets — PPAR δ , FFAR1 , DPP4 , PYGL , PTPN1 , and FFAR4 — can be considered especially interesting.A comparison of the data between Table 1 and Table 2 suggests that , in general , the studied bornyl derivatives exert a bifunctional multitarget effect with high significance ; mainly , they decrease insulin resistance ( five significant targets : PPAR δ , FFAR1 , PTPN1 , FFAR4 , and PPAR α ) and also have properties of incretin-mimetics ( three significant targets : DPP4 , GIPR , and GLP1R ) .