sentence: ORM1 is involved in modulating the activity of the immune system during the acute-phase reaction with the degranulation of neutrophils.In addition to insulin some of the other most significantly downregulated protein between T1D and the control cases is PFKB2 which is involved in glycolysis , hydroxyacyl-CoA dehydrogenase ( HADH ) which is involved in the beta-oxidation pathway and ATP2A3 , magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium and STX1A , syntaxin 1A which is involved in peptide hormone metabolism and insulin secretion [ 50 ] .