sentence: There are two major WHSC1L1 isoforms , the long WHSC1L1 ( 1437aa ) and the short WHSC1L1 ( 645aa ) , which share a common 620aa N-terminal region , while the short WHSC1L1 lacks the SET domain.Given that WHSC1L1 is recurrently amplified in SCCHN and that few studies have explored the role of PKMTs in SCCHN [ 8] , we aimed to evaluate its potential function as an oncogenic force in this disease , and to elucidate relevant mechanisms of its oncogenic activity .