sentence: The Debcl-induced apoptosis is mediated by other factors including ; the mitochondrial fission protein Drp1 ( Clavier et al ., 2015 ) that interacts with Debcl to induce mitochondrial fragmentation ; Glycerophosphate oxidase-1 ( Colin et al ., 2015 ) that increases mitochondrial ROS accumulation ; and possibly through the initiation of autophagy , since both α - synuclein expression ( Xilouri & Stefanis , 2015 ) and Debcl ( Hou et al ., 2008 ) overexpression are implicated in this process .