sentence: Three Phase II / III clinical trials enrolling patients with squamous cell carcinomas of head and neck ( SCCHN ) demonstrated that Gendicine in combination with radiotherapy showed obvious synergistic effects.37 – 39 An extended follow-up on a subset of nasopharyngeal carcinoma patients , in which 82 patients were randomized to receive Adp53 injection and radiotherapy ( GTRT ; n = 42 ) or radiotherapy alone ( RT ; n = 40 ) , showed that complete response rate in the GTRT group was observed at 2.73 times that of the RT group ( 66.7 % vs 24.4 % ) .40 Upregulation of p21 / WAF1 and Bax and downregulation of vascular endothelial growth factor were observed in postinjection tumor biopsy .