sentence: Obviously , future studies , using larger number of human culture samples and additional , different types of assays are warranted to unequivocally establish if the overexpresion of In1-ghrelin variant observed in all the human pituitary adenomas analyzed herein is directly associated with an increase in proliferation and a decrease in apoptotic rate observed in these human pituitary pathologies.In NFPAs , no functional studies had been implemented to date and , therefore , the role of the ghrelin system in this pathology remained unknown1 .