sentence: These results are supported by the effects of other antidepressants , such as desipramine , which also inhibits depressive-like behavior provoked by chronic mild stress by activating both the HO-1 and NQO1 isoenzymes in the prefrontal cortex [ 64 ] , and reveal the participation of NQO1 in the antidepressant effects of oltipraz.In conclusion , this study showed that the intraperitoneal administration of oltipraz inhibited the mechanical and thermal sensitization induced by CCI by modulating the balance between oxidative stress and proinflammatory pathways triggered by microglia in the spinal cord .