sentence: Taken together , our findings hint that iron chelation may inhibit mTORC1 by activating AMPK , leading to increased interactions of p-raptor ( S792 ) and PRAS40 with mTOR.To determine whether activation of AMPK is truly responsible for iron chelation-induced mTORC1 inhibition , A549 , A427 , and Rh30 cells were pretreated with Compound C , an AMPK inhibitor , followed by CPX or Dp44mT treatment for 24 h.