sentence: For example , the recommended phase II dose of the ATRi M6620 when combined with carboplatin is a quarter of the dose intensity compared with the recommended M6620 monotherapy dose.44 45 Other significant high grade toxicities that have been reported include drug-induced liver dysfunction for ceralasertib46 and SRA737 ,47 as well as high grade pulmonary toxicity with triapine use.48 Although dose-limiting cardiac toxicities were reported in 4.7 % of patients enrolled on a phase I dose-escalation study of the CHK1 / 2 inhibitor AZD7762 ( AstraZeneca ) in combination with gemcitabine ,49 praxasertib has not been associated with this feared side effect , even at the maximal tolerated dose .