sentence: For factors responsible for Nrf2 repression , one report proposed that BRD4 expression is up-regulated by high glucose concentrations in the mouse podocyte cell line MPC5 [ 93 ] , whereas another report indicated that GSK3 β , which is known to repress Nrf2 activity in a β TrCP-proteasome-dependent manner , is activated in diabetic fetal endothelial cells [ 94 ] .