sentence: With regard to the importance of the BAF complex and distinct subunit switches in neural development , it is not surprising that mutations in BAF-coding genes are associated with neurodevelopmental disorders such as Coffin – Siris syndrome , Nicolaides – Baraitser syndrome or autism spectrum disorders.One of the syndromes commonly caused by mutations in BAF subunits is the Coffin – Siris syndrome ( CSS ) , first described in 1970 as a combination of intellectual disability , growth retardation , joint malformations and brachydactyly combined with hypoplastic or missing fingernails at the fifth finger / toe [ 124 , 125 ] .