sentence: 50 As we have learned from difficulties combining high-potency PARPi with chemotherapy due to toxic myelosuppression , the sequential administration of chemotherapy followed by maintenance PARPi has led to clinical approvals , and this may be the required approach for novel ATRi – WEE1i – CHK1i.Another area that deserves further exploration is the crosstalk between enhanced replicative stress with the immune response .