sentence: In contrast , cycles of sequential PARPi for 1 week followed by WEE1i for 1 week were associated with long-term tolerability and marked prolongation of the depth and duration of tumor shrinkage compared with either inhibitor alone.39 Sequential treatment may retain its clinical efficacy while improving tolerability , therefore the phase I STAR study is evaluating sequential olaparib followed by adavosertib in PARPi-resistant patients with known mutations in DNA damage response genes ( Table 1 ) .