sentence: The third and fourth lines of evidence that TpbA is a tyrosine phosphatase were found using tyrosine specific substrates ; TpbA-cHis dephosphorylated both phosphotyrosine peptides , END ( pY ) INASL ( peptide type I ) and DADE ( pY ) LIPQQG ( peptide type II ) ( Fig. 6C ) , and this activity was inhibited by trisodium orthovanadate .