sentence: Systematic analysis of the presence and functional implications of some components of the ghrelin system , including native ghrelin , receptors and the recently discovered splicing variant In1-ghrelin , in human normal pituitaries ( n = 11 ) and pituitary adenomas ( n = 169 ) revealed that expression pattern of ghrelin system suffers a clear alteration in pituitary adenomasas comparedwith normal pituitary , where In1-ghrelin is markedly overexpressed .