sentence: With the use of TUG-891 , Hudson et al. [ 160 ] confirmed the anti-inflammatory and insulin-sensitizing effects of FFAR4 agonism ; on the other hand , the limited selectivity of the compound between murine FFA1 and FFA4 receptors and its rather low potency when looking at endogenously expressed FFA4 receptors are two obstacles that prevent its use in translating in vitro results into in vivo effects .