sentence: Among U snRNAs , the 2 ′ - O-methylation of U6 snRNA at positions A47 , C60 and C62 was reduced to ~ 50 % in TFIP11-depleted cells , though strikingly this was not the case upon depletion of DHX15 or coilin ( Fig. 6a to e ) , indicating strong specificity of the methylation defect .