sentence: DPWG guidelines also recommend dose changes for aripiprazole , risperidone , and haloperidol in CYP2D6 PMs , but no CPIC guidelines , at the time of writing , exist for antipsychotics.CYP2D6 metabolizer status strongly influences the metabolism of antipsychotics , leading to changes in pharmacokinetic parameters , including overall exposure as defined by the area under the concentrationtime curve ( AUC ) , half-life , clearance , and steady-state concentration .