sentence: During the activation of NF - κ B , I κ Bs are phosphorylated by activated IKK , and then the NF - κ B p50 / p65 heterodimer is released and transferred to the nucleus , which finally regulates the innate immune responses ( Bonizzi and Karin , 2004 ; Hayden and Ghosh , 2008 ; Chiu et al ., 2009b ; Iwai , 2014 ) .