sentence: These findings underscore a potentially important role of ARHGEF3 in the development and progression of NPC , and suggest that examination of ARHGEF3 expression by IHC could be used as an additional tool in identifying those NPC patients at increased risk of tumor growth and / or metastasis.Our investigation of the mechanisms through which ARHGEF3 regulates NPC cell malignancy demonstrated that knockdown of ARHGEF3 in CNE2 and SUNE1 NPC cells dramatically repressed cell growth , migration , and invasion in vitro .