sentence: Altogether , this makes the DA neurons in SN especially susceptible to mitochondrial dysfunction , and the resultant energy deficits could contribute mightily to DA-related impairments , such as those occurring in PD ( Horowitz et al ., 2011 ; Venkateshappa et al ., 2012 ; Burbulla et al ., 2017 ; Prots et al ., 2018 ) .