sentence: Other proteins positively associated with frailty in our study were coagulation factor IXab , IL ‐ 1Ra , and FSTL3 that play important roles in homeostasis ( Mari , Coppola , & Provenzano , 2008 ) , inflammation ( De Martinis , Franceschi , Monti , & Ginaldi , 2006 ) , and cardiovascular outcomes ( Heidecker et al ., 2015 ) , respectively , all important contributors to frailty.The top most protein negatively associated with frailty was ANTR2 ( anthrax toxin receptor protein 2 ) , also called capillary morphogenesis gene 2 ( CMG2 ) , which is characterized by its binding ability to anthrax toxin .