sentence: We have previously demonstrated that the metabolites of sesamin and episesamin ; SC1 ( ( 7 α ,7 ′ α ,8 α ,8 ′ α ) -3,4 - dihydroxy-3 ′ ,4 ′ - methylenedioxy-7 ,9 ′ :7 ′ ,9 - diepoxylignane ) , EC1 ( ( 7 α ,7 ′ β ,8 α ,8 ′ α ) -3,4 - dihydroxy-3 ′ ,4 ′ - methylenedioxy-7 ,9 ′ :7 ′ ,9 - diepoxylignane ) , or ( ( 7 α ,7 ′ β ,8 α ,8 ′ α ) -3,4 - methylenedioxy-3 ′ ,4 ′ - dihydroxy-7 ,9 ′ :7 ′ ,9 - diepoxylignane ) ; produced by P-450 have potent antioxidative effects [ 21,28 ] .