sentence: These data confirmed that our optimized L. major promastigote drug susceptibility HTS assay format could be used to identify compounds exhibiting in vitro as well as in vivo leishmanicidal activity.The percentage of compounds in these two validation assays that were identified as growth inhibitory was relatively high , namely 10.5 % and 22.6 % for the diverse LOPAC and the more focused UP-CMLD DP sets , respectively , as would be expected under low stringency conditions .