sentence: Finally , we saw a highly significant decrease in the proportion of CD11c + myDCs in the IFN-beta-treated subjects.Although the absolute number of T cells , especially CD4 + T cells , and CD19 + B cells decreased in the CSF of IFN-beta-treated subjects , the proportions of HLA-DR + T cells , both CD4 + and CD8 + , actually increased , paralleling the same proportional increases of these recently activated T cells in the blood of IFN-beta-treated subjects .