sentence: These traits could facilitate rapid changes in gene expression in response to various regulatory stimuli and major biological defects when that control is disrupted.A key result from our study was to show that XRN4 substrates include NMD-sensitive targets such as CPuORF , and upf1 - and upf3-elevated transcripts ( Figure 3C and D ; Supplementary Table S4 and Supplementary Dataset S2 ) .