sentence: In contrast to the LEM domain proteins otefin , bocksbeutel , and dMAN1 , and several newly identified nuclear envelope transmembrane proteins that depend on lamins for their INM localization ( Wagner et al ., 2004 , 2006 ; Malik et al ., 2010 ) , Kuk localizes at the INM even when lamin Dm0 is down-regulated , which indicates that Kuk is tethered at the NM without depending on lamin Dm0 .