sentence: As would be expected , these data confirm that the decay of many XRN4 substrates are impacted by VCS and fit well with our PARE analysis that demonstrated the importance of decapping and 5 ′ to 3 ′ decay.One category of transcripts that overaccumulates decapped intermediates in xrn4 is comprised of those with annotated CPuORFs in their 5 ′ UTRs .