sentence: Thus , the PARE libraries made from polyA + and polyA - RNA from two xrn4 mutants ( xrn4 – 5 and xrn4 – 6 ) and two replicates of the WT that were grown alongside provide the means to extend knowledge about this set of XRN4 substrates and to identify others.We first examined whether the known accumulation of the miRNA-guided cleavage intermediates of ARF10 mRNA in xrn4 mutants reported previously could be recapitulated with PARE .