sentence: SorLA belongs to the family of vacuolar protein sorting 10 protein ( VPS10P ) - domain receptors [ 15 ] , and is well characterized for its protective role in Alzheimer ’ s disease , and for bolstering insulin signaling in adipose tissue , by regulating the traffic and biological function of the amyloid precursor protein and the insulin receptor , respectively [ 14 , 16 , 17 ] .