Some newer drugs such as selegiline and moclobemide have proven to be safer than the older MAOIs and are prescribed by physicians in the first instance .
In the past , MAOIs were prescribed for those resistant to tricyclic antidepressant therapy , but newer MAOIs such as selegiline and moclobemide provide a safer alternative and are now sometimes used as first-line therapy , although these substances are not always as effective as their predecessors .