His grandson and successor Charles , was to inherit not only the Spanish lands of his maternal grandparents , but the Habsburg and Burgundian lands of his paternal family , which would make his heirs the most powerful rulers on the continent and , with the discoveries and conquests in the Americas and elsewhere , of the first truly global Empire .
The succession of his grandson Charles , who inherited not only the Spanish lands of his maternal grandparents , but the Habsburg and Burgundian lands of his paternal family , would make his heirs the most powerful rulers on the continent .