It flows west to east and crosses the Paktia Province Afghan-Pakistan border at Coordinates : 33 ° 49 ′ N 69 ° 58 ′ E \ / 33.817 ° N 69.967 ° E \ / 33.817 ; 69.967 about 80 km southwest of Jalalabad , and joins the Indus near Isa Khel after a course of more than 320 km ( 200 mi ) .
It crosses the Afghan-Pakistan border about 80 km southwest of Jalalabad , and joins the Indus near Isa Khel after a course of more than 320 km ( 200 miles ) .