Identification of the receptor hinged on the positional cloning of the mammalian Lps locus , which had been known since the 1960s as a key genetic determinant of all biological responses to LPS .
Identification of the receptor hinged on the positional cloning ( a method of gene identification ) of the mammalian Lps locus , which had been known since the 1960s as a key gene for biological responses to LPS .