In his NFL debut game on September 11 , 2011 , Newton was 24 -- 37 passing for 422 yards , 2 touchdowns and 1 interception , in a 28 -- 21 road loss to the Arizona Cardinals .
In his first NFL game on September 11 , 2011 , Newton was 24 -- 37 passing for 422 yards , 2 touchdowns and 1 interception in a 28 -- 21 road loss to the Arizona Cardinals .