Knoxville 's textile and manufacturing industries largely fell victim to foreign competition in the 1950s and 1960s , and after the establishment of the Interstate Highway system in the 1960s , the railroad-which had been largely responsible for Knoxville 's industrial growth-began to decline .
After the building of the Interstate Highway system in the 1960s , the railroad-which had been largely responsible for Knoxville 's industrial growth-began to decline .