Additional proteins such as coactivators , chromatin remodelers , histone acetylases , deacetylases , kinases , and methylases , while also playing crucial roles in gene regulation , lack DNA-binding domains , and , therefore , are not classified as transcription factors .
Other proteins such as coactivators , chromatin remodellers , histone acetylases or deacetylases , kinases , and methylases , also playing crucial roles in gene regulation . Because they lack DNA-binding domains , they are not transcription factors .