Her TV roles include characters on `` The Simpsons '' , where she voices Agnes Skinner , Brandine Spuckler and Lindsey Naegle , and `` Futurama '' , in which her main role is the character Mom .
Her most famous characters on `` The Simpsons '' include Agnes Skinner , Brandine Spuckler and Lindsey Naegle , while her performance as Mom is her most notable `` Futurama '' role .