Xanthine oxidase inhibitors ( including allopurinol and febuxostat ) block uric acid production , and long-term therapy is safe and well tolerated , and can be used in people with renal impairment or urate stones , although allopurinol has caused hypersensitivity in a small number of individuals .
Xanthine oxidase inhibitors ( including allopurinol and febuxostat ) block uric acid production .