One main exception to this is when , in rare cases , a male has XXY chromosomes ( see Klinefelter 's syndrome ) , in which case the male could have tortoiseshell or calico markings .
It is possible for a male cat to be a calico if it has Klinefelter 's syndrome , where it has two X chromosomes and one Y chromosome , though not all cats with Klinefelter 's syndrome are calico .