ejaasaari/simplewiki-2025-04-01 huggingface dataset:
RNA interference (RNAi) is a process in living cells. It adjusts (moderates) the activity of their genes. RNAi molecules are a key to gene regulation. In 2006, Andrew Fire and Craig Mello shared the Nobel Prize in Physiology or Medicine for their work on RNA interference in the nematode worm "Caenorhabditis elegans", published in 1998. Two types of small RNA molecules – microRNA (miRNA) and small interfering RNA (siRNA) – do the work. These small RNAs bind to normal messenger RNA (mRNA) molecules and increase or decrease their activity. They can prevent a mRNA from producing a protein. RNA interference defends cells against foreign nucleotide sequences – viruses and transposons. Also, they control development, and gene expression in general. The RNAi pathway is found in many eukaryotes including animals. RNAi is a valuable research tool, in cell culture and in living organisms. Synthetic dsRNA introduced into cells can suppress specific genes of interest. RNAi may be used for large-scale screens that shut down each gene to analyse cellular process or cell division. The pathway is also used as a practical tool in biotechnology and medicine. Functions. Natural functions. The natural functions of RNA interference are:
Deidre Ann Hall (born October 31, 1947 in Milwaukee, Wisconsin, USA) is an American actress and producer. She has been featured in many television soap opera shows. She played "Dr. Marlena Evans" in "Days of Our Lives" for more than 30 years. References. &lt;br&gt;
Emerson Drive are a Canadian country band from Grande Prairie, Alberta. Emerson Drive have five members in the band; the current band members are Danick Dupelle, Brad Mates, Mike Melancon, David Pichette and Dale Wallace. The band was formed in 1995 originally known under the name 12 Gauge. The band was forced to change their name because a rap group had already owned the name. They decided to choose Emerson Drive as their name and is named for the Emerson Trail that crosses Western Alberta and joins the Alaskan Highway. They released their debut album "Open Season" in 1996. Their newest album "Decade of Drive" was released on February 8, 2011. They will release their seventh studio album in 2012. The first single, "She's My Kind of Crazy" was released on July 16, 2012. On September 25, 2007, the bands bassist Patrick Bourque committed suicide in his Montreal, Quebec home. Bourque had quit the band in July of that year. The band has been nominated for many awards including a Grammy Award for Best Country Performance by a Duo or Group with Vocals for their song "Moments" in 2008 and many Canadian Country Music Association awards.
William McKinley, the 25th President of the United States, was shot on September 6, 1901, inside the Temple of Music on the grounds of the Pan-American Exposition in Buffalo, New York. He died eight days later from gangrene caused by the wound. Shooting and death. On September 6, 1901, McKinley was shaking hands with the people when he was shot by the anarchist Leon Czolgosz. He died eight days later from his gunshot wounds. He was 58 years old. It was later known that Czolgosz killed the President in an attempt to advance anarchism. Czolgosz was executed by the electric chair on October 29, 1901. McKinley's vice president, Theodore Roosevelt, became America's 26th president of the United States of America.
The assassination of President James A. Garfield happened in Washington, D.C. on July 2, 1881. Garfield was shot in the back by Charles J. Guiteau at about 9:30 am, less than four months into Garfield's term as the 20th President of the United States.  Guiteau shot Garfield after being mad at him about not receiving credit for Garfield's victory in 1880 after he wrote a speech about Garfield but never made the speech. The 31st Speaker of the United States House of Representatives James G. Blaine was at Garfield's side when he was shot down. Garfield died eleven weeks later on September 19, 1881 aged 49. He was the second of four presidents to be assassinated, after Abraham Lincoln and the next president to be assassinated would be William McKinley and next John F. Kennedy. His vice president, Chester A. Arthur, became the next president after Garfield. And on June 2, 1882, Guiteau was executed by hanging, aged 40. Garfield also lived the longest after the shooting than the other presidents who were assassinated. Lincoln and Kennedy died less than a day after being shot, and McKinley died a week later.
The Sámi languages are a branch of Uralic languages spoken by the Sámi people. They are spoken in Norway, Sweden, Finland, and Russia. They are related to the Finnish, the Estonian, and the Hungarian language. "The Sámi languages ... are sometimes considered dialects of one language", says Encyclopædia Britannica; those who speak one Sámi language, [mostly] do not understand other Sami languages; "[t]he Sámi languages share many features (or things,) with the Baltic-Finnic languages (Finnish, Estonian, Karelian, etc.)," but "they cannot be closely related to any of these"... "[T]heir grammars are similar to that of Finnish, although their syntax has been influenced by the Scandinavian languages." Some researchers of linguistics, have an idea that the Sami languages have come from a "proto-Sámi language"; That kind of a language, can have existed c. 500 before Common Era. Among the Sámi languages are
James Gillespie Blaine (January 31, 1830 – January 27, 1893) was an American Republican politician. He was a United States Representative. He was the Speaker of the United States House of Representatives. He was a U.S. Senator from Maine. He was the Secretary of State twice. He was also nominated to be President. Early life. Blaine was born on January 31, 1830 in West Brownsville, Pennsylvania. He was the third child of Ephraim Lyon Blaine and his wife Maria Gillespie Blaine. He was educated at Washington College and later met his wife Harriet Stanwood. They married in 1850 and they had seven children. Career. Blaine was a Republican. He was Speaker of the House of Representatives from 1869 until 1875. He was chosen by the 18th United States President Ulysses S. Grant. Blaine would later served as the Senator from Maine from 1876 through 1881. Secondly he served as the Member of the U.S. House of Representatives from Maine's 3rd district from 1863 until 1876. Then as the 28th and 31st United States Secretary of State from 1881 through 1881 and then again in 1889 through 1892. On July 2, 1881, Blaine and President James A. Garfield were walking in the Baltimore and Potomac Railroad station in Washington, D.C. when Charles J. Guiteau shot Garfield in the back. Blaine resigned as Secretary of State several months later. The Republicans nominated Blaine for President in 1884 but Grover Cleveland won the election. Death. Blaine died just 4 days short from his 63rd birthday on January 27, 1893 in his Washington, D.C. home from a heart attack, aged 62. He was later buried at Oak Hill Cemetery in Washington, D.C. and was later re-buried in Blaine Memorial Park, Augusta, Maine, in 1920. Blaine was hypochondriac.
Okinawa is one of Japan's southern prefectures. Okinawa may also refer to:
Burt Freeman Bacharach (May 12, 1928 – February 8, 2023) was an American composer, singer, songwriter, and music producer. He wrote many hit songs. He was born in Kansas City, Missouri. He won three Academy Awards, two Golden Globe Awards, two Grammy Awards and one BAFTA Award during his career. Some songs were written specifically for the singers who originally recorded them. Some of his songs were: Bacharach died on February 8, 2023 at his Los Angeles home from natural causes. He was 94 years old.
Dame Kristin Scott Thomas (born 24 May 1960) is an English actress. She was born in Redruth, Cornwall. She received international praise in the 1990s for "Four Weddings and a Funeral" and "The English Patient". She has acted in many other movies during her career. Her sister, Serena Scott Thomas (born 1961), is also an actress.
Jonathan Harshman Winters (November 11, 1925 – May 11, 2013) was an American comedian, television, stage, voice, movie actor, and artist. Winters had appeared in several television shows and in movies. He was recently known for voicing Papa Smurf in the 2011 movie "The Smurfs". In "", he was replaced by Jack Angel. Early life. Winters was born Jonathan Harshman Winters in Dayton, Ohio on November 11, 1925. He is of Irish-Scottish-English descent. During his senior year at Springfield High School, Winters quit school to join the United States Marine Corps and served two and a half years in the Pacific Theater during World War II. After his return, he attended Kenyon College. He later studied cartooning at Dayton Art Institute, where he met Eileen Schauder, whom he married on September 11, 1948. He was a brother of the Delta Kappa Epsilon fraternity (Lambda chapter). Career. Beginning in 1960, Winters recorded many classic comedy albums for the Verve Records label. He also had comedy albums released every decade for over 50 years, receiving 11 Grammy Award for Best Comedy Album nominations during his career, and winning the Grammy Award for Best Spoken Comedy Album for Crank(y) Calls in 1996. In 1957, he was the first comedian in the United States to be on color television, a 15-minute routine sponsored by Tums. Winters has also appeared in hundreds of television show episodes/series and movies combined, including eccentric characters on "The Steve Allen Show", "The Garry Moore Show", "The Wacky World of Jonathan Winters" (1972–74), "Mork &amp; Mindy", "Hee Haw" and in "It's a Mad, Mad, Mad, Mad World". After voicing Grandpa Smurf on "The Smurfs" (1980–2009) and Papa Smurf in "The Smurfs", Winters's final feature movie was "The Smurfs 2" in 2013, which will
Paul Dooley Brown (born February 22, 1928) is an American movie, television, voice actor, writer, and comedian. He is known for his voice role as Sarge in the Disney-Pixar animated movies "Cars," "Cars 2 and Cars 3." Dooley was born on February 22, 1928 in Parkersburg, West Virginia. Dooley married Winnie Holzman in 1984. They have a daughter, Savannah Dooley.
Anthony Marcus "Tony" Shalhoub (born October 9, 1953) is an American movie, stage, television, and voice actor. He is known for his roles as Adrian Monk in "Monk", Alexander Minion in the first three "Spy Kids" movies, and as Luigi in "Cars" and in "Cars 2". Shalhoub has also appeared in plays on stage. Biography. He was born in Green Bay, Wisconsin on October 9, 1953. Shalhoub is married to Brooke Adams since 1992 and they have two children.
Richard Anthony Marin (born July 13, 1946) is an American actor and writer. He was part of the comedy duo Cheech and Chong along with fellow comedian Tommy Chong. He played Ramone in the Disney-Pixar animated movies "Cars", "Cars 2", and "Cars 3". Early life. Marin was born Richard Anthony Marin on July 13, 1946 in Los Angeles, California. Marin was married to Darlene Morley from 1975 until they divorced in 1984. They had one child. He was married to Patti Heid from 1986 until they divorced. They had 2 children. He has been married to Natasha Rubin since 2009. Marin lives in Malibu, California. He is Mexican-American.
Katherine Marie Helmond (July 5, 1929 – February 23, 2019) was an American film, theater and television actress and director, who portrayed Emily Dickinson on "Meeting of Minds", as well as fictional characters, for which she was best-known, such as Jessica Tate on "Soap", Mona Robinson on "Who's the Boss?", Doris Sherman on "Coach", and Lois Whelan on "Everybody Loves Raymond" and Mrs. Lowry in "Brazil". Helmond was born in Galveston, Texas on July 5, 1929. She was married to George N. Martin from 1957 until they divorced in 1962. She married her second husband David Christian in 1962. She has no children. Helmond died on February 23, 2019, from complications of Alzheimer's disease at her home in Los Angeles. aged 89.
Joseph Anthony "Joe" Mantegna (born November 13, 1947) is an American movie, stage, television, voice actor, producer, writer, and director. He did the voice of Fat Tony in "The Simpsons". He also played David Rossi in "Criminal Minds". He also played Ian "The Shark" in "Airheads". He played Grem in the Disney-Pixar animated movie "Cars 2". He has won a Tony Award. Mantegna was born in Chicago, Illinois. He has been married to Arlene Vrhel since 1975 and they have two children.
William Horton "Bill" Kurtis (born September 21, 1940) is an American television journalist, producer, narrator, news anchor, and historian who anchored "CBS Morning News". He has also narrated crime shows and in movies. Kurtis mostly spent his childhood in Chicago, Illinois. He studied his B.S. degree at the University of Kansas and his J.D. degree at Washburn University of Law. He was married to Helen Kurtis from 1966 until her death in 1977, they had two children (one who died). He is currently partners with Donna La Pietra.
Walter David Jacobson (born July 28, 1937) is an American, historian, and television personality. He is the anchor of WBBM-TV news at 6:00 pm. He was the anchor of WFLD news until his retirement in 2006. Jacobson was born in Chicago, Illinois on July 28, 1937. He attended New Trier High School and Grinnell College. He got a B.A. degree. He went to Columbia University in New York to receive his J.D. degree. He was married to Lynn Straus from 1960 until they divorced in the 1970s. They had two children including actor Peter Jacobson. He was married to Diane Dybsky from 1980 until they divorced. They had two children. He has been married to Susan Jacobson since 1995.  He currently lives in Chicago, Illinois. On June 18, 2008 Jacobson was arrested for DUI driving near his Chicago home. He pleaded guilty and received supervision. On November 2002 he slipped on a pumpkin in his house and broke several ribs.
Dale Evans Rogers (born Lucille Wood Smith; October 31, 1912 – February 7, 2001), best known as Dale Evans, was an American writer, movie actress, and singer-songwriter. She was the third wife of singing cowboy Roy Rogers. Evans was born in Uvalde, Texas on October 31, 1912. She was married to Thomas Frederick Fox from 1927 until they divorced in 1929. They had a son. She was later married to August Wayne Johns from 1929 until they divorced in 1935. Her third husband was R. Dale Butts. They were married from 1937 until they divorced in 1946. Her last husband was Roy Rogers. They were married from 1947 until his death in 1998. They had one child and 4 adopted children. Evans died on February 7, 2001 in Apple Valley, California from heart failure, aged 88.
Edgar Peter Lougheed, PC, CC, AOE, QC, (July 26, 1928 – September 13, 2012) was a Canadian lawyer, politician, and professional football player. Early life. Lougheed was born on July 26, 1928 in Calgary, Alberta. He studied at the University of Alberta and at Harvard University.  Lougheed was married to Jeanne Rogers until his death in 2012. They had four children.  Career. In 2012, the Institute for Research on Public Policy named him the best Canadian premier of the last 40 years. He was the 10th Premier of Alberta from September 10, 1971 through November 1, 1985.  Lougheed has also been a member of the Legislative Assembly of Alberta for Calgary West from May 23, 1967 through February 28, 1986. Death. Lougheed died on September 13, 2012 in Peter Lougheed Hospital in Calgary, Alberta from natural causes, aged 84.
Christopher Peter Meloni or Chris Meloni (born April 2, 1961) is an American movie, voice, and television actor. He is best known for his television roles as NYPD Detective Elliot Stabler in "" and as Chris Keller in "Oz". Meloni also appeared as Colonel Hardy in the 2013 movie "Man of Steel". Meloni was born on April 2, 1961 in Washington, D.C.. He is of Canadian-French descent. Since 1995, he has been married to Doris Sherman Williams. They have two children. Meloni is a long-time gay rights supporter.
Alfred Molina (born Alfredo Molina; 24 May 1953) is an English actor. He played Diego Rivera in "Frida", Dr. Sayeed Bozorg Mahmoody in "Not Without My Daughter", Satipo in "Raiders of the Lost Ark", Dr. Octopus in "Spider-Man 2" and "", and Maxim Horvath in "The Sorcerer's Apprentice". Molina was born on 24 May 1953 in Paddington, London, England to an Italian mother and Spanish father. He grew up in Notting Hill, London. He studied at Guildhall School of Music and Drama. Molina was married to actress Jill Gascoine from 1986 until her death in 2020. He has one daughter from another relationship. In 2019, he began dating Jennifer Lee. They were married in 2021. Molina lives in Los Angeles, California.
Kevin Delaney Kline (born October 24, 1947) is an American stage, television, voice, and movie actor. He has won an Academy Award and two Tony Awards. Kline was nominated for five Golden Globe Awards, two BAFTA Awards, and an Emmy Award. He is known for his role as Otto West in "A Fish Called Wanda", as both President Mitchell and Dave in "Dave", and as both Artemus "Artie" Gordon and President Ulysses S. Grant in the 1999 movie "Wild Wild West". He is currently the voice of Mr. Fischoeder in "Bob's Burgers". Personal life. Kline was born in St. Louis, Missouri on October 24, 1947. He has been married to Phoebe Cates since 1989. They have two children.
Joshua Andrew Koenig (August 17, 1968 - February 25, 2010) was an American actor, director, activist, editor and writer. Koenig is probably best known for playing Mike Seaver's best friend, Richard "Boner" Stabone on the sitcom Growing Pains. He was in 25 episodes of Growing Pains and also guest starred on episodes of 21 Jump Street, My Two Dads and My Sister Sam. Koenig starred in the 2003 fan film where he played The Joker. His father is Walter Koenig also an actor. Koenig disappeared on February 14, 2010. His parents said he showed signs of depression before he went missing. His body was found hanging from a tree in Vancouver's Stanley Park, on February 25, 2010.
Jeffrey DeMunn (born April 25, 1947) or Jeff DeMunn is an American stage, movie and television actor. He played Harry Terwilliger in the movie "The Green Mile". He played Dale Horvath in the TV series "The Walking Dead". He was born in Buffalo, New York and studied at the Uninon College. DeMunn was married to Ann Sekjaer in 1974 until they divorced in 1995. They had two children. DeMunn has been married to Kerry Leah since 2001.
Lynn Rachel Redgrave, OBE (8 March 1943 – 2 May 2010) was an English actress. She has been nominated for many other awards including the Academy, BAFTA and Emmy awards. Redgrave starred in many movies and plays as well as working on television. She made her Broadway debut in 1967. She was the sister of actress Vanessa Redgrave and actor Corin Redgrave. She was an aunt of actresses Natasha Richardson and Joely Richardson. Redgrave died of breast cancer.
Highmark Stadium is a large stadium in Orchard Park, New York. It is the home of the Buffalo Bills team. The stadium has had several names during its history. It opened in 1973 as Rich Stadium, after the food products company of that name. After the sponsorship contract ran out in 1998, it was renamed Ralph Wilson Stadium in honor of Ralph Wilson (1918-2014), the team's founding owner from 1960 until his death in 2014. A new sponsorship contract with locally based headwear company New Era in 2016 led to a new name of New Era Field. In July 2020, New Era asked to be released from its contract, and the stadium became Bills Stadium for the 2020 NFL season. The current name took effect in March 2021, after regional health insurance company Highmark Blue Cross Blue Shield signed a 10-year naming deal. On June 5, 2023, construction started on a new stadium. The new stadium will be the new home of the Buffalo Bills and will replace Highmark Stadium. The new stadium will also have naming rights by Highmark.
Veronica Lake (November 14, 1922 – July 7, 1973) was an American movie actress and pin-up model. She was well liked by both audiences and critics. Lake is most notably known for her role in "Sullivan's Travels" and for her femme fatale roles in film noir with Alan Ladd during the 1940s. These include "This Gun for Hire". Lake had bad marriages. At the end of her career, she had problems with mental illness and alcoholism. She was born in Brooklyn. Her father was of Irish and Danish ancestry. Paramount Pictures had Lake under contract.
The Little Sandy Desert is a desert in Western Australia. South of the Little Sandy Desert is the Great Sandy Desert and to west of it is the Gibson Desert. It is to the east of Great Northern Highway, which is south of the town Newman and about 200 kilometres north of Wiluna. It is named because it is close and looks like the Great Sandy Desert, but it is much smaller. Both deserts are crossed by the Canning Stock Route.  It is one of Western Australia's "Interim Biogeographic Regionalisation for Australia" (IBRA) regions.
Edward Davis "Ed" Wood, Jr. (October 10, 1924 – December 10, 1978) was an American director, producer, screenwriter, actor, author, and editor who is known for his works in low-budget horror or fantasy movies and is also known for his works with Bela Lugosi. Wood is considered one of the worst movie directors of all time. His most famous were "Plan 9 from Outer Space, Bride of the Monster" and "Glen or Glenda". Wood was born in Poughkeepsie, New York on October 10, 1924. At a young age, because his mother had wanted a girl, he was forced to dress up as a girl and would have that crossdressing habit for the rest of his life. Wood had a lifelong attraction to the feel of angora.  Wood was married to Norma McCarty in 1956 until they divorced several months later. Then he married Kathy O'Hara in 1956. They were married until his death in 1978. Wood had an illigitimate daughter from a 1946 relationship who lived in NY.  Wood died on December 10, 1978 in Los Angeles, California from a heart attack, aged 54.  A 1994 movie was released based on Wood's life directed by Tim Burton. Johnny Depp played Wood in the movie.
John Cabell "Bunny" Breckinridge (August 6, 1903 – November 5, 1996) was an American movie and television actor and drag queen. He was best known for his role as The Ruler in Ed Wood's movie "Plan 9 from Outer Space". That was the only movie role in his career. He was born in Paris, France to an American family. Breckinridge was gay and talked about having a sex change operation but never had it. He died on November 5, 1996 in San Francisco, California from natural causes, aged 93. In the 1994 movie "Ed Wood" he was played by Bill Murray.
Walter Andrew Brennan (July 25, 1894 – September 21, 1974) was an American movie, television, and stage actor. He was in the TV series "The Real McCoys". He is tied with Jack Nicholson for the actor winning the most Academy Awards. Brennan was born in Lynn, Massachusetts on July 25, 1894 and studied at Rindge Technical High School. He was married to Ruth Wells from 1920 until his death in 1974, they had three children. He died on September 21, 1974 in Oxnard, California from emphysema, aged 80.
George Harris Kennedy, Jr. (February 18, 1925 – February 28, 2016) was an American movie, voice, radio, stage, and television actor. He won an Academy Award for his role as Dragline in "Cool Hand Luke". He played Carter McKay in the "Dallas" television series, Chief Mechanic Joe Patroni in the "Airport" movie series and Captain Ed Hocken in the "Naked Gun" movie series. Kennedy was born on February 18, 1925 in New York City. He studied at Chaminade High School and at Tarleton State University. He married Dorothy Gillooly in the 1940s. He was married to Norma Wurman from 1959, until they divorced in 1971. He remarried Wurman in 1973; they divorced again in 1978. He was married to Joan McCarthy from 1978, until her death in 2015. He had two children. He lived in Eagle, Idaho. Kennedy died in a retirement home in Middleton, Idaho from heart disease on February 28, 2016 at the age of 91.