Original: Set in Pasadena , California , the show concerns two male Caltech prodigies in their twenties , one an experimental physicist ( Leonard ) and the other a theoretical physicist ( Sheldon ) , who live across the hall from an attractive blonde waitress with show-biz aspirations ( Penny ) .
Simplified: It concerns two male Caltech prodigies in their twenties , one an experimental physicist ( Leonard ) and the other a theoretical physicist ( Sheldon ) , who live across the hall from an attractive blonde waitress with show-biz aspirations ( Penny ) .