pysimplegui (pypi): Python GUIs for Humans. Launched in 2018. It's 2022 & PySimpleGUI is an ACTIVE & supported project. Super-simple to create custom GUI's. 325+ Demo programs & Cookbook for rapid start. Extensive documentation. Main docs at www.PySimpleGUI.org. Fun & your success are the focus. Examples using Machine Learning (GUI, OpenCV Integration), Rainmeter Style Desktop Widgets, Matplotlib + Pyplot, PIL support, add GUI to command line scripts, PDF & Image Viewers. Great for beginners & advanced GUI programmers.
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