iGEM 2012 — Team Harvey_Mudd

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# Team:Harvey Mudd/Notebook

### From 2012.igem.org

This is a template page. READ THESE INSTRUCTIONS.

You are provided with this team page template with which to start the iGEM season. You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki. You can find some examples [HERE](https://2008.igem.org/Help%3ATemplate/Examples).

You **MUST** have all of the pages listed in the menu below with the names specified. PLEASE keep all of your pages within your teams namespace.

| [Home](/Team%3AHarvey_Mudd "Team:Harvey Mudd") | [Team](/Team%3AHarvey_Mudd/Team "Team:Harvey Mudd/Team") | [Official Team Profile](https://igem.org/Team.cgi?year=2012&team_name=Harvey_Mudd) | [Project](/Team%3AHarvey_Mudd/Project "Team:Harvey Mudd/Project") | [Parts Submitted to the Registry](/Team%3AHarvey_Mudd/Parts "Team:Harvey Mudd/Parts") | [Modeling](/Team%3AHarvey_Mudd/Modeling "Team:Harvey Mudd/Modeling") | **Notebook** | [Safety](/Team%3AHarvey_Mudd/Safety "Team:Harvey Mudd/Safety") | [Attributions](/Team%3AHarvey_Mudd/Attributions "Team:Harvey Mudd/Attributions") |
| --- | --- | --- | --- | --- | --- | --- | --- | --- |

From iGEM: You should make use of the calendar feature on the wiki and start a lab notebook. This may be looked at by the judges to see how your work progressed throughout the summer. It is a very useful organizational tool as well.

We might do that eventually. For now, we can keep track of progress here.

6/4: Last night I finally proved uniqueness for the steady-state equations for TALOR systems. The good news: that's done. The bad news: TALORs cannot build bistable systems without some other component. The model used also applies to TFOs.

6/19: A 1991 paper [http://pubs.acs.org/doi/abs/10.1021/ja00015a076 reported] successful use of TFOs with regions designed to dimerize. The two TFOs form a much more stable triplex after dimerization, exactly as needed for bistable circuit design. The downside is that it requires DNA oligos, and I have no idea how those come about in vivo.

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