iGEM 2019 — Team UniGE-Geneva

[![](https://2019.igem.org/wiki/images/8/8b/HQ_page_logo.jpg)](https://2019.igem.org)

# Team:UniGE-Geneva/Notebook

Unige iGEM 2019

* [Home](Unige.html)
* [About Us](Unige2.html)
* AAA

# Inspiration

The replacement of animal testing by alternative in vitro methods is now being encouraged by the World Health Organization and the US Food and Drug Administration (FDA). However, replacing animal models is a big challenge for laboratories because current in vitro cell cultures poorly reflect the physiological organization of tissues. This has led to low success rates for drugs because a high proportion (~98%) of those that appear efficacious in vitro do not succeed during in vivo trials. Therefore, we believe there is an urgent need to improve in vitro drug testing to better simulate the in vivo physiology of animal models.

# Project

We would like to create a drug-testing toolbox that is capable of measuring the effects of multiple interdependent biological activities with physiological relevance. By mimicking physiological conditions that occur in vivo, our goal is to improve in vitro drug testing to reduce the reliance on animal experimentation, as well as increase the efficiency and accuracy of drug screening. For this aim, we will use novel cell co-culture formats, including cancer and hepatocyte cell lines. Importantly, our co-culture formats aim to improve upon several aspects of existing spheroid cultures.

# Content

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dkskdssldhsdghsdkjghsdgjhsdghsdkgsdgss

![](https://static.igem.org/mediawiki/2019/3/3c/Igem_mobile_menu_logo.svg)

![](https://static.igem.org/mediawiki/2019/e/ee/2019_team_menu_icon.svg)

[![](https://placehold.it/350x150/ececec/cecece)](https://2019.igem.org/Team%3AUniGE-Geneva)
[HOME](https://2019.igem.org/Team%3AUniGE-Geneva)

TEAM

[Team Members](https://2019.igem.org/Team%3AUniGE-Geneva/Team)
[Collaborations](https://2019.igem.org/Team%3AUniGE-Geneva/Collaborations)

PROJECT

[Description](https://2019.igem.org/Team%3AUniGE-Geneva/Description)
[Design](https://2019.igem.org/Team%3AUniGE-Geneva/Design)
[Experiments](https://2019.igem.org/Team%3AUniGE-Geneva/Experiments)
[Notebook](https://2019.igem.org/Team%3AUniGE-Geneva/Notebook)
[Contribution](https://2019.igem.org/Team%3AUniGE-Geneva/Contribution)
[Results](https://2019.igem.org/Team%3AUniGE-Geneva/Results)
[Demonstrate](https://2019.igem.org/Team%3AUniGE-Geneva/Demonstrate)
[Improve](https://2019.igem.org/Team%3AUniGE-Geneva/Improve)
[Attributions](https://2019.igem.org/Team%3AUniGE-Geneva/Attributions)

PARTS

[Parts Overview](https://2019.igem.org/Team%3AUniGE-Geneva/Parts)
[Basic Parts](https://2019.igem.org/Team%3AUniGE-Geneva/Basic_Part)
[Composite Parts](https://2019.igem.org/Team%3AUniGE-Geneva/Composite_Part)
[Part Collection](https://2019.igem.org/Team%3AUniGE-Geneva/Part_Collection)

[SAFETY](https://2019.igem.org/Team%3AUniGE-Geneva/Safety)

HUMAN PRACTICES

[Human Practices](https://2019.igem.org/Team%3AUniGE-Geneva/Human_Practices)
[Education & Engagement](https://2019.igem.org/Team%3AUniGE-Geneva/Public_Engagement)

AWARDS

[Entrepreneurship](https://2019.igem.org/Team%3AUniGE-Geneva/Entrepreneurship)
[Hardware](https://2019.igem.org/Team%3AUniGE-Geneva/Hardware)
[Measurement](https://2019.igem.org/Team%3AUniGE-Geneva/Measurement)
[Model](https://2019.igem.org/Team%3AUniGE-Geneva/Model)
[Plant](https://2019.igem.org/Team%3AUniGE-Geneva/Plant)
[Software](https://2019.igem.org/Team%3AUniGE-Geneva/Software)

[JUDGING FORM ⇗](https://igem.org/2019_Judging_Form?team=UniGE-Geneva)

# Notebook

Document the dates you worked on your project. This should be a detailed account of the work done each day for your project.

### What should this page have?

* Chronological notes of what your team is doing.
* Brief descriptions of daily important events.
* Pictures of your progress.
* Mention who participated in what task.

### Inspiration

You can see what others teams have done to organize their notes:

* [2018 Munich](https://2018.igem.org/Team%3AMunich/Notebook)
* [2014 ATOMS-Turkiye](https://2014.igem.org/Team%3AATOMS-Turkiye/Notebook)
* [2014 Tec Monterrey](https://2014.igem.org/Team%3ATec-Monterrey/ITESM14_project.html#tab_notebook)
* [2014 Kyoto](https://2014.igem.org/Team%3AKyoto/Notebook/Magnetosome_Formation#title)
* [2014 Cornell](https://2014.igem.org/Team%3ACornell/notebook)


[![](https://2019.igem.org/wiki/images/8/8b/HQ_page_logo.jpg)](https://2019.igem.org)

# Team:UniGE-Geneva/Experiments

[![](https://2019.igem.org/wiki/images/8/8b/HQ_page_logo.jpg)](https://2019.igem.org)

# Team:UniGE-Geneva/Results

Unige iGEM 2019

* [Home](Unige.html)
* [About Us](Unige2.html)
* AAA

# Inspiration

The replacement of animal testing by alternative in vitro methods is now being encouraged by the World Health Organization and the US Food and Drug Administration (FDA). However, replacing animal models is a big challenge for laboratories because current in vitro cell cultures poorly reflect the physiological organization of tissues. This has led to low success rates for drugs because a high proportion (~98%) of those that appear efficacious in vitro do not succeed during in vivo trials. Therefore, we believe there is an urgent need to improve in vitro drug testing to better simulate the in vivo physiology of animal models.

# Project

We would like to create a drug-testing toolbox that is capable of measuring the effects of multiple interdependent biological activities with physiological relevance. By mimicking physiological conditions that occur in vivo, our goal is to improve in vitro drug testing to reduce the reliance on animal experimentation, as well as increase the efficiency and accuracy of drug screening. For this aim, we will use novel cell co-culture formats, including cancer and hepatocyte cell lines. Importantly, our co-culture formats aim to improve upon several aspects of existing spheroid cultures.

# Content

FOHEFEOUFHEOUFHOEFHOEUFHEUFHEIHFEHF
dkskdssldhsdghsdkjghsdgjhsdghsdkgsdgss

![](https://static.igem.org/mediawiki/2019/3/3c/Igem_mobile_menu_logo.svg)

![](https://static.igem.org/mediawiki/2019/e/ee/2019_team_menu_icon.svg)

[![](https://placehold.it/350x150/ececec/cecece)](https://2019.igem.org/Team%3AUniGE-Geneva)
[HOME](https://2019.igem.org/Team%3AUniGE-Geneva)

TEAM

[Team Members](https://2019.igem.org/Team%3AUniGE-Geneva/Team)
[Collaborations](https://2019.igem.org/Team%3AUniGE-Geneva/Collaborations)

PROJECT

[Description](https://2019.igem.org/Team%3AUniGE-Geneva/Description)
[Design](https://2019.igem.org/Team%3AUniGE-Geneva/Design)
[Experiments](https://2019.igem.org/Team%3AUniGE-Geneva/Experiments)
[Notebook](https://2019.igem.org/Team%3AUniGE-Geneva/Notebook)
[Contribution](https://2019.igem.org/Team%3AUniGE-Geneva/Contribution)
[Results](https://2019.igem.org/Team%3AUniGE-Geneva/Results)
[Demonstrate](https://2019.igem.org/Team%3AUniGE-Geneva/Demonstrate)
[Improve](https://2019.igem.org/Team%3AUniGE-Geneva/Improve)
[Attributions](https://2019.igem.org/Team%3AUniGE-Geneva/Attributions)

PARTS

[Parts Overview](https://2019.igem.org/Team%3AUniGE-Geneva/Parts)
[Basic Parts](https://2019.igem.org/Team%3AUniGE-Geneva/Basic_Part)
[Composite Parts](https://2019.igem.org/Team%3AUniGE-Geneva/Composite_Part)
[Part Collection](https://2019.igem.org/Team%3AUniGE-Geneva/Part_Collection)

[SAFETY](https://2019.igem.org/Team%3AUniGE-Geneva/Safety)

HUMAN PRACTICES

[Human Practices](https://2019.igem.org/Team%3AUniGE-Geneva/Human_Practices)
[Education & Engagement](https://2019.igem.org/Team%3AUniGE-Geneva/Public_Engagement)

AWARDS

[Entrepreneurship](https://2019.igem.org/Team%3AUniGE-Geneva/Entrepreneurship)
[Hardware](https://2019.igem.org/Team%3AUniGE-Geneva/Hardware)
[Measurement](https://2019.igem.org/Team%3AUniGE-Geneva/Measurement)
[Model](https://2019.igem.org/Team%3AUniGE-Geneva/Model)
[Plant](https://2019.igem.org/Team%3AUniGE-Geneva/Plant)
[Software](https://2019.igem.org/Team%3AUniGE-Geneva/Software)

[JUDGING FORM ⇗](https://igem.org/2019_Judging_Form?team=UniGE-Geneva)

# Results

Here you can describe the results of your project and your future plans.

### What should this page contain?

* Clearly and objectively describe the results of your work.
* Future plans for the project.
* Considerations for replicating the experiments.

### Describe what your results mean

* Interpretation of the results obtained during your project. Don't just show a plot/figure/graph/other, tell us what you think the data means. This is an important part of your project that the judges will look for.
* Show data, but remember **all measurement and characterization data must also be on the part's Main Page on the Registry.** Otherwise these data will not be in consideration for any medals or part awards!
* Consider including an analysis summary section to discuss what your results mean. Judges like to read what you think your data means, beyond all the data you have acquired during your project.

### Project Achievements

You can also include a list of bullet points (and links) of the successes and failures you have had over your summer. It is a quick reference page for the judges to see what you achieved during your summer.

* A list of linked bullet points of the successful results during your project
* A list of linked bullet points of the unsuccessful results during your project. This is about being scientifically honest. If you worked on an area for a long time with no success, tell us so we know where you put your effort.

### Inspiration

See how other teams presented their results.

* [2014 TU Darmstadt](https://2014.igem.org/Team%3ATU_Darmstadt/Results/Pathway)
* [2014 Imperial](https://2014.igem.org/Team%3AImperial/Results)
* [2014 Paris Bettencourt](https://2014.igem.org/Team%3AParis_Bettencourt/Results)