'''라정찬'''(1963년 10월 18일 )은 대한민국의 줄기세포 연구자이며 기업인이다. == 경력 사항 == (주) 알바이오 줄기세포 기술연구원 연구원장 베데스다 병원 이사장 바이오스타 그룹 회장 (주) 한국 기독교 학술원 이사 네이처셀 대표이사 사회복지법인 줄기세포생명재단 설립자 == 주요 업적 == 지방유래 줄기세포 치료제 「아스트로스템」 개발 알츠하이머 줄기세포 치료기술, 日서 세계 최초 상용화 세계 최초 지방 줄기세포 계대 배양 공정 확립 세계 최초 통합줄기세포은행 구축 세계 최초 류마티스관절염, 자가면역성 난청 환자 치료성공 자가 지방줄기세포로 정맥내 투여를 통한 항노화 난치병 치료기술 개발 == 수상 == 2007. 대한민국 기술대상 산자부 장관상 2009. 대한민국 신기술 으뜸상 대상 지식경제부 2009. 장영실 한국과학기술대상 장영실 선생 기념 사업회 2011. 한국 기독교 학술상 수상 2012. 5.16 민족상 수상 과학 기술 개발 부분 == 학력 == 1986년 서울 대학교 수의과대학 1994년 서울 대학교 수의과대학 석사 2008년 제주 대학교 수의학과 박사 2012년 벨헤이븐 대학교 과학 부문 명예 박사 == 연구 논문 == Jun-Ho Kim, Kang-Il Kim, Wan Keun Yoon, Sang-Jun Song, Wook Jin. Intra-articular Injection of Mesenchymal Stem Cells after High Tibial Osteotomy in Osteoarthritic Knee: Two-Year Follow-up of Randomized Control Trial. Stem Cells Translational Med. 2022 Jun 8;szac023. doi: PMID: '''35674255''' Kang-Il Kim, Woo-Suk Lee, Jun-Ho Kim, Jung-Kwon Bae, Wook Jin. Safety and Efficacy of the Intra-articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritic Knee: 5-Year Follow-up Study. Stem Cells Translational Med. 2022 May 14;szac024. doi: PMID: '''35567774''' Ra K, Oh HJ, Kim EY, Kang SK, Ra JC, Kim EH, Lee BC. Anti-Oxidative Effects of Human Adipose Stem Cell Conditioned Medium with Different Basal Medium during Mouse Embryo In Vitro Culture. Animals 2020 Aug 13;10(8):1414. doi: PMID 32823702 Ra K, Oh HJ, Kim GA, Kang SK, Ra JC, Lee BC. High Frequency of Intravenous Injection of Human Adipose Stem Cell Conditioned Medium Improved Embryo Development of Mice in Advanced Maternal Age through Antioxidant Effect. Animals 2020, 10, 978; Lee SH, Ra JC, Oh HJ, Kim MJ, Setyawan EMN, Choi YB, Yang JW, Kang SK, Han SH, Kim GA, Lee BC. Clinical Assessment of Intravenous Endothelial Progenitor Cell ransplantation in Dogs. Cell Transplant. 2019 doi: Epub 2019 Apr 24. PMID 31018670 Shin K, Cha Y, Ban YH, Seo DW, Choi EK, Park D, Kang SK, Ra JC, Kim YB. effect of combinational treatment with human adipose tissue-derived mesenchymal stem cells and thrombospondin in rabbit. World Stem cells 11(12): 1115-1129. PMID 31875872. Park CH, Yang PS, Yoon YS, Ra JC Study on the safety of Polygala tenuifolia Willdenow root extract powder (BT-11) in young person aged from to 19 years old Ethnopharmacol, 2019 Mar; 25232:119-129 PMID 30576772 Kim GA, Lee Y, Kim HJ, Oh HJ, Kang SK, Ra JC, Lee BC Intravenous human endothelial progenitor cell administration into aged mice enhances embryo development and oocyte quality by reducing inflammation, endoplasmic reticulum stress and apoptosis. Vet Med Sci, 2018 Dec; PMID 30369585 Jeong-Chan Ra Novel Approach to Developing in Vitro Culture Method for Enhancing Anti-Cancer Nature of ADMSCs," Current Trends in Biomedical Engineering Biosciences, 2018. vol. 11(4), pages 78-79, January. Jeong-Chan Ra, Hyo Jung Choi and Yoon Kim Effect of Multiple Intrathecal Administrations of Cultured Human Autologous Adipose-Derived Stem Cells in the Patients with Neurological Disorders Including Parkinson’s Disease -J Clin Case Rep 2018, Vol 8(10): 1183. DOI 바로가기 Lee SH, Setyawan EMN, Choi YB, Ra JC, Kang SK, Lee BC, Kim GA Clinical assessment after human adipose stem cell transplantation into dogs. Vet Sci, 2018 May; 3119(3):452-461 PMID 29284215 Jeong-Chan Ra, Yun-Joung Kim and Eun-Young Kim Effect of the Multiple Intravenous Administration of Cultured Human Autologous Adipose-Derived Stem Cells on Tumor Biomarker Levels Clin Case Rep 2017, Vol 7(11): 1040. DOI: 바로가기 Ra JC, Jeong EC, Kang SK, Lee SJ, Choi KH Prospective, Nonrandomized, no Phase I/II Clinical Trial Assessing the Safety and Efficacy of Intramuscular Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells in Patients With Severe Buerger's Disease. Cell Med, 2016 Oct; 39(3):87-102 PMID 28713639 *Ha S, Park H, Mahmood U, Ra JC, Suh YH, Chang KA. Human adipose-derived stem cells ameliorate repetitive behavior, social deficit and anxiety in VPA-induced autism mouse model. Behav Brain Res. 2017 Jan 15;317:479-484. doi: Epub 2016 Oct 4. PMID: 27717813. Kim D, Kyung J, Park D, Choi EK, Kim KS, Shin K, Lee H, Shin IS, Kang SK, Ra JC, Kim YB Health Span-Extending Activity of Human Amniotic Membrance-and Adipose Tissue-Derived Stem Cells in F344 Rats Stem Cells Transl Med, 2015 PMID 26315571 Han SM, Park CW, Ahn Jo, Park SC, Jung WS, Seo KW, Ra JC, Kang SK Lee HW, Youn HY Pro-apoptotic and Effect of Canine Adipose Tissue-derived Mesenchymal Stem Cells Against Melanoma Cells Anticancer Res, 2015 PMID 26254365 Choi HS, Kim HJ, Oh JH, Park HG, Ra JC, Chang KA, Suh YH Therapeutic potentials of human adipose-derived stem cells on the mouse model of Parkinson's disease Neurobiol Aging, 2015 PMID 26242706 Han SH, Jang G, Bae BK, Han SM, Koh YR, Ahn JO, Kang SK, Ra JC, Lee HW, et al. Effect of ectopic OCT4 expression on canine adipose tissue-derived mesenchymal stem cell proliferation. Cell Biol Int 2014 PMID 24797505 Jo CH, Lee YG, Shin WH, Kim H, Chai JW, Jeong EC, Kim JE, Shim H, Ra JC, Oh S, Yoon KS. Intra-Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: Clinical Trial Stem Cells, 2014 PMID 24449146 Kim KS, Lee HJ, Kim YB, Ra JC, Lim I, Kim SU Transplantation of Human Adipose Tissue-Derived Stem Cells Delays Clinical Onset and Prolongs Life Span in ALS Mouse Model Cell Transplant, PMID 24070071 Han SM, Han SH, Coh YR, Jang G, Ra JC Kang SK, Lee HW, Youn HY Enhanced proliferation and differentiation of Oct4- and human adipose tissue mesenchymal stem cells Exp Mol Med, 2014 Jun 20; 46:e101 PMID 24946789 Choi YK, Din FU, Kim DW, Kim YI, Kim JO, Ku SK, Ra JC, Huh JW, Lee JI, Sohn DH et al. Amniotic membrane extract-loaded double-layered wound dressing: evaluation of gel properties and wound healing Drug Dev Ind Pharm 2014, 40(7):852-859 PMID 23621769 Choi SW, Park KB, Woo SK, Kang SK, Ra JC Treatment of progressive supranuclear palsy with autologous adipose tissue-derived mesenchymal stem cells: case report Med Case Rep, 2014 Mar 4; 8:87 PMID 24594311 Choi JW, Park EJ, Shin HS, Shin IS, Ra JC Koh KS In Vivo Differentiation of human adipose tissue-derived mesenchymal stem cells in critical-sized calvarial bone defects. Ann Plast Surq. 2014 PMID 23221992 Choi EW, Shin IS, Park SY, Yoon EJ, Kang SK, Ra JC, Hong SH Characteristics of mouse Adipose Tissue-Derived stem cells and therapeutic Comparisons Between syngeneic and allogeneic adipose tissue-derived stem cell transplantation in experimental autoimmune thyroiditis Cell Transplant. PMID 23485102 Kim YM, Oh SH, Choi JS, Lee S, Ra JC, Lee JH, Lim JY Adipose-Derived Stem Cell-Containing Hyaluronic Acid/Alginate Hydrogel Improves Vocal Fold Wound Healing Larynqoscope. 2014 Mar, 124(3):E64-72 PMID 24115025 Park DS, Yang G, Bae DK, Lee SH, Yang YH, Kim D, Choi EK, Kang SK, Ra JC, Kim YB. Human Adipose Tissue-Derived Mesenchymal stem cells improve cognitive Function and Physical Activity in Ageing Mice Neurosci Res, 2013 May 91(5):660-670 PMID 23404260 Park DS, Lee SH, Bae DK, Yang YH, Yang G, Kyung JB, Kim D, Choi EK, Hong JT, Shin IS, Kang SK, Ra JC, Kim YB. Transplantation of Human Adipose Tissue-Derived Mesenchymal Stem Cells Restores the Neurobehavioral Disorders of Rats With Neonatal Encephalopathy Cell Med 2013 Feb 7;5(1):17-28 PMID 26858861 Lim J-Y, Ra JC, Shin IS, Jang YH, An HY, Choi JS, Kim WC, Kim YM. Systemic Transplantation of Human Adipose Tissue-Derived Mesenchymal Stem Cells for the Regeneration of Salivary Gland Damage PLoS One,2013 Aug, 8(8):e71167. PMID 23951100 Ahn JO, Lee HW, Seo KW, Kang SK, Ra JC, Youn HY. Anti-Tumor Effect of Adipose Tissue Stem Cells Expressing Interferon-β and Treatment with Cisplatin in Xenograft Mouse Model for Canine Melanoma Plos One,2013 Sep, 8(9): e74897. PMID 24040358 Kim IG, Piao, JY Lee, SH Hong, TK Hwang, SW Kim, CS Kim, JC Ra, Noh and JY Lee. Effect of an Adipose Derived Stem Cells and Nerve Growth Hydrogel on Recovery of Erectile Function in Rat Model of Cavernous Nerve Injury. Tissue Engineering. Part .2013, 19 (1-2):14-23. PMID 22834730 Kim S, Chang KA, Kim JA, Park HG,Ra JC, Kim HS, Suh YH The Preventive and therapeutic effects of intravenous human adipose-derived stem cells in Alzheimer's disease mice. PLoS One. PMID 23049854 Oh HJ, EJ Park, SY Lee, JW Soh, IS Kong, SW Choi, JC Ra, SK Kang and BC Lee. Comparison of cell proliferation and epigenetic modification of gene expression patterns in canine foetal fibroblasts and adipose tissue-derived mesenchymal stem cells. Cell Proliferation. 2012. 45:438?444. PMID 22925503 Kim MJ, Oh HJ, Kim GA, Park JE, Park EJ, Jang G, Ra JC, Kang SK, Lee BC. Lessons learned from cloning dogs. -Reprod Domest Anim. 2012 Aug;47 Suppl 4:115-9 PMID 22827359 Koh KS, TS Oh, Kim, IW Chung, KW Lee, HB Lee, EJ Park, IS Shin, JC Ra and JW Choi. Clinical application of human adipose tissue-derived mesenchymal stem cells in progressive hemifacial atrophy (parry-romberg disease) with microfat grafting techniques using 3-dimensional computed tomography and 3-dimensional camera. Annals of Plastic Surgery 2012. 69:331-337. PMID 22907186 Fang CH, Jin, JH Joe, YS Song, BI So, SM Lim, SK Woo, JC Ra, YY Lee and KS Kim. In Vivo Differentiation of Human Amniotic Epithelial Cells into Cells and Cell Transplantation Effect on Myocardial Infarction in Rats: Comparison with Cord Blood and Adipose Tissue-Derived Mesenchymal Stem Cells. Cell 2012. PMID 22776022 Piao S, Kim IG, Lee JY, Hong SH, Kim SW Hwang TK, Oh SH, Lee JH, Ra JC, Lee JY Therapeutic Effect of Adipose-Derived Stem Cells and PLGA Membrane in Rat Model of Cavernous Nerve Injury Sex Med. 2012 May 29. doi: PMID 22642440 Park YS, Lim GW, Cho KA, Woo SY, Shin M, Yoo ES, Ra JC, Rhy KH. Improved viability and activity of neutrophils differentiated from HL-60 cells by co-culture with adipose tissue-derived mesenchymal stem cells BBRC 2012, in press PMID 22609208 Kang SK, Shin IS, Ko MS, Jo JY, Ra JC. Journey of Mesenchymal Stem Cells for Homing: Strategies to Enhance Efficacy and Safety of Stem Cell Therapy. (Review article) Stem Cells Int. Epub 2012 Jun 13. PMID 22754575 Kang JW, Koo HC, Hwang SY, Kang SK, Ra JC, Lee MH, Park YH. effects of human amniotic mesenchymal stem cells. Journal of Veterinary Science 2012, 13(1):23-31. PMID 22437532 Choi EW, Shin IS, Park SY, Park JH, Kim JS, Yoon EJ, Kang SK, Ra JC, Hong SH. Reversal of serological, immunological and histological dysfunction in systemic lupus erythematosus mice by long-term serial adipose tissue-derived mesenchymal stem cell Arthritis Rheum. 2012, ;64(1):243-53. PMID 21904997 Kwon EB Lee JY, Piao S, Kim IG, Ra JC, Lee JY Comparison of human muscle-derived stem cells and human adipose derived stem cells in neurogenic Korean Urol. 2011 PMID 22216399 Ra JC, Kang SK, Shin IS, Park HG, Joo SA, Kim JG, Kang BC, Lee YS, Nakama K, Piao M, Sohl B, Kurtz A. Stem cell treatment for patients with autoimmune disease by systemic infusion of autologous adipose tissue derived mesenchymal stem cells. Trans Med 2011, 9(1):18. PMID 22017805 Baek SJ, Kang SK, Ra JC. In vitro migration capacity of human adipose-derived mesenchymal stem cells and their expression of distinct set of chemokine and growth factor receptors. EXPERIMENTAL and MOLECULAR MEDICINE, 43,(10), 596-603. PMID 21847008 Kim MJ, Oh HJ, Park JE, Kim GA, Hong SG, Jang G, Kwon MS, Koo BC, Kim T, Kang SK, Ra JC, Ko C, Lee BC Generation of transgenic dogs that conditionally express green fluorescent protein. Genesis. 2011, 49(6):472-8. PMID 21630415 Ko MS, Park HG, Yun YM, Ra JC, Shin T, Lee KK The ameliorative effects of human adipose tissue-derived mesenchymal stem cells (hAdMSCs) on MBP-induced einduced induced xperimental autoimmune (EAE) in Lewis rats. Neural Regen Res. 2011, 6(16):1205-1210 Hwang JH, Kim IG, Lee JY, Piao S, Lee DS, Lee TS, Ra JC, Lee JY Therapeutic using stem cell and VEGF-C hydrogel.- Biomaterials. 2011, 32(19):4415-23. PMID 21421266. Ko MS, Jung JY, Shin IS, Choi EW, Kim JH, Kang SK, Ra JC Effects of Expanded Human Adipose Tissue -Derived Mesenchymal Stem Cells on the Viability of Cryopreserved Fat Grafts in the Nude Mouse. 2011; 8(3):231-238 PMID 21448310. Choi HJ, Kim JM, Kwon E, Che JH, Lee JI, Cho SR, Kang SK, Ra JC, Kang BC Establishment of Efficacy and Safety Assessment Human Adipose Tissue-Derived Mesenchymal Stem Cells (hATMSCs) in Nude Rat Femoral segmental Defect Model Korean Med Sci 2011; 26: 482-491 PMID 21468254 Ra JC Shin IS, Kim SH, Kang SK, Kang BC, Lee HY, Kim YJ, jo JY, Yoon EJ, Choi HJ, Kwon Safety of intravenous infusion of human adipose tissue derived mesenchymal stem cells in animals and humans Stem Cells Dev. 2011, PMID 21303266 Choi EW, Shin IS, Lee HW, Park SY, Park JH, Nam MH, Kim JS, Woo SK, Yoon EJ, Kang SK, Ra JC, Woun HY, Hing SH Transplantation of CTLA4Ig gene-transduced adipose tissue-derived mesenchymal stem cells reduces inflammatory immune response and improves Th1/Th2 balance in experimental autoimmune thyroiditis. The Journal of Gene Medicine. 2011 13(1): 3-16 PMID 21259404. Oh HJ, Park JE, Kim MJ, Hong SG, Ra JC, Jo JY, Kang SK, Jang G, Lee BC Recloned dogs derived from adipose stem cells of transgenic cloned beagle. Theriogenology 75 (2011) 1221-1231 PMID 21220163. Kim BH, Son WC, Yim CO, Kang SK, Yim CO, Ra JC, Kim YC. Anti-Wrinkle Effects of Adipose Tissue-Derived Mesenchymal Stem Cells in UV-Irradiated Hairless Mouse Model. Tissue Engineering and Regenerative Medicine. Woo SK, Jo JY, Shin IS, Kang SK, Ra JC New Isolation Technique and Culture System for Clinical Applications of Human Amniotic Epithelial Stem Cells.- Development and Reproduction Jo JY, Kang SK, Choi IS, Ra JC. Comparison of Neural Cell Differentiation Mesenchymal Stem Cells Derived from Young and Old Ages. Development and Reproduction Hong SG, Kim MK, Jang G, Oh HJ, Park JE, Kang JT, Koo OJ, Kim T, Kwon MS, Koo BC, Ra JC, Kim DY, Ko C, Lee BC Generation of red fluorescent protein transgenic dogs. Genesis. 2009, 47(5): 314-22 PMID 19358155. Jo EH, Kim SH, Ra JC, Kim SR, Cho SD, Jung JW, Yang SR, Park JS, Hwang JW, Aruoma OI, Kim TY, Lee YS, Kang KS. Chemopreventive properties of the ethanol extract of chinese licorice (Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells. Cancer Lett. 2005 Dec doi: 16297710. == 특허 == '''특허명''' '''국가명''' '''특허 출원''' '''특허 등록''' '''출원일''' '''출원번호''' '''등록일''' '''등록번호''' 지방유래 줄기세포를 함유하는 사지말단부 허혈성 질환의 세포치료용 조성물 일본 2009.11.25 2010-510198 2013.06.14 5290281 중국 2009.11.25 200880017490.9 2013.04.24 인간지방조직 유래 다분화능 줄기세포 모낭세포를 함유하는 세포치료제 대한민국 2007.05.02 10-2007-0042645 2014.07.25 10-1425653 호흡가스를 이용한 유방암의 측정방법 대한민국 2011.07.05 10-2011-0066602 혈관 투여에 적합한 크기를 가지는 줄기세포의 제조방법 대한민국 2013.04.17 10-2013-0042517 2014.11.25 10-1467480 미국 2014.10.17 14/395,170 일본 2014.10.20 2015-506897 2016.04.28 5926447 중국 2014.11.17 201380025722.6 2017.07.04 호주 2014.10.17 2013250089 2016.12.01 2013250089 인도 2014.10.17 7672/CHENP/2014 멕시코 2014.10.16 2018.09.12 359004 남아공 2014.10.17 2014/07585 2016.01.27 2014/07585 유럽 2014.10.17 13 777 949.2 2017.04.28 2840133 줄기세포의 파쇄 응집 방지 방법 조성물 대한민국 2013.04.15 10-2013-0041022 2014.11.25 10-1467481 미국 2014.10.14 14/394,402 2016.09.06 9,433,645 일본 2014.10.14 2015-505655 2016.05.13 5931277 중국 2014.11.17 201380025698.6 2017.09.05 남아공 2014.10.13 2014/07412 2016.09.28 2014/07412 멕시코 2014.10.10 2018.09.12 359002 홍콩 2015.09.21 15109256.3 2018.10.19 1208498 유럽 2014.10.13 13 775 784.5 2017.09.20 2837682 고농도의 줄기세포 제조방법 대한민국 2012.06.26 10-2012-0068796 2015.05.19 10-1523040 남아공 2014.12.04 2014/08915 2015.11.25 2014/08915 인도 2014.12.22 9205/CHENP/2014 2019.02.05 306838 호흡가스를 이용한 암의 진단방법 대한민국 2013.12.19 10-2013-0159373 2014.11.25 10-1467482 미국 2015.06.26 14/758,176 2018.05.01 9,955,898 일본 2015.06.24 2015-550302 2017.06.16 6159821 중국 2015.06.26 201380068473.9 2018.01.02 정맥 투여용 줄기세포 조성물 대한민국 2013.05.15 10-2013-0055158 2016.01.04 10-1583569 미국 2015.11.11 14/890,585 일본 2015.11.16 2016-513860 2017.05.12 6141522 중국 2015.12.15 201480034107.6 홍콩 2016.09.02 16110479.1 유럽 2015.12.09 14 798 312.6 줄기세포의 재생능 향상을 위한 배지 조성물 이를 이용한 줄기세포의 배양방법 대한민국 2013.05.09 10-2013-0052558 2016.01.19 10-1588394 미국 2015.11.05 14/889,434 2018.05.29 9,982,234 일본 2015.11.09 2016-512813 2018.01.05 6267324 유럽 2015.11.30 14 795 109.9 말초혈액 유래 혈관내피 전구세포의 분리 배양방법 대한민국 2015.10.06 10-2015-0140435 줄기세포의 보관 안정성 증진용 조성물 대한민국 2015.10.13 10-2015-0142806 2016.02.19 10-1597604 미국 2016.09.14 15/126,231 2019.01.08 10,172,347 일본 2016.11.24 2016-569967 중국 2017.01.03 201580036349.3 유럽 2016.12.01 15 818 206.3 암세포의 증식을 억제하는 중간엽 줄기세포의 제조방법 미국 2019.01.29 16/321,520 일본 2019.01.29 2019-527108 유럽 2019.02.27 17 834 820.7 중국 2019.03.25 201780058891.8 감마선 조사 혈청을 이용한 중간엽 줄기세포의 배양방법 대한민국 2018.05.25 10-2018-0059594 미국 2019.05.24 16/422,525 일본 2019.05.27 2019-098293 항암 바이러스가 도입된 중간엽 줄기세포의 세포 생존능을 향상시키는 방법 대한민국 2018.06.15 10-2018-0069245 건강한 사람의 면역세포 배양액을 이용한 NK 세포의 함량을 증진시키는 방법 대한민국 2019.06.17 10-2019-0071257 줄기세포를 이용한 바이러스 감염증 예방 치료용 의약조성물 대한민국 2020.02.18 10-2020-0019381 항암바이러스와 항암제를 포함하는 중간엽 줄기세포를 함유하는 암치료용 세포치료제 이의 제조방법 대한민국 2020.01.31 10-2020-0012083 == 저서 == 2010. 고맙다, 줄기세포(위즈덤하우스) *2012. The grace of stem cells (Tate Publishing and Enterprises, LLC) *2012. 谢谢你，干细胞 (Wisdomhouse) *2013. ありがとう幹細胞 (御茶の水書房) *2014. 치매, 희망 있습니다(끌리는책) *2018. СТВОЛОВЫЕ КЛЕТКИ, СПАСИБО! (Издательство ИТРК) *2019. عطايا الخلايا الجِذْعَِّية (Batana) == 외부 링크 == 공식 웹사이트 트위터 라정찬 == 각주 == 분류:1963년 출생 분류:살아있는 사람 분류:청주시 출신 분류:대한민국의 저술가 분류:서울대학교 수의과대학 동문 분류:서울대학교 수의과대학원 동문 분류:대한민국의 기업인 분류:대한민국의 생물학자