Target family: Chromatin modifying enzymes (<i>Plasmodium</i> spp.) (type: other_protein)
Target: Plasmodium falciparum histone deacetylase 1

Ligand: JX35 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8.789999961853027 pIC50
Reference (Journal): Drug Repurposing of Quisinostat to Discover Novel <i>Plasmodium falciparum</i> HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety.
Published in: J Med Chem

Ligand: JX21108 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.409999847412109 pEC50
Reference (Journal): A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1.
Published in: Cell Discov

Ligand: JX21108 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8.229999542236328 pEC50
Reference (Journal): A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1.
Published in: Cell Discov

Ligand: JX21108 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8.4399995803833 pEC50
Reference (Journal): A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1.
Published in: Cell Discov

Ligand: JX21108 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8.399999618530273 pEC50
Reference (Journal): A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1.
Published in: Cell Discov

Ligand: FNDR-20123 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.71999979019165 pIC50
Reference (Journal): Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria.
Published in: Malar J

Ligand: FNDR-20123 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.71999979019165 pIC50
Reference (Journal): Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria.
Published in: Malar J

Ligand: FNDR-20123 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.599999904632568 pIC50
Reference (Journal): Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria.
Published in: Malar J

Ligand: FNDR-20123 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.880000114440918 pIC50
Reference (Journal): Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria.
Published in: Malar J

Ligand: FNDR-20123 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.840000152587891 pIC50
Reference (Journal): Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria.
Published in: Malar J

Ligand: FNDR-20123 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.760000228881836 pIC50
Reference (Journal): Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria.
Published in: Malar J

Ligand: FNDR-20123 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.389999866485596 pIC50
Reference (Journal): Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria.
Published in: Malar J

Ligand: compound 2h [PMID: 30664827] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8.279999732971191 pIC50
Reference (Journal): Structure-Activity and Structure-Toxicity Relationships of Peptoid-Based Histone Deacetylase Inhibitors with Dual-Stage Antiplasmodial Activity.
Published in: ChemMedChem

Ligand: compound 1u [PMID: 30245402] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 9 pIC50
Reference (Journal): One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites.
Published in: Eur J Med Chem

Ligand: compound 1u [PMID: 30245402] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.599999904632568 pIC50
Reference (Journal): One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites.
Published in: Eur J Med Chem

Ligand: compound 1u [PMID: 30245402] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8.399999618530273 pIC50
Reference (Journal): One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites.
Published in: Eur J Med Chem