Target family: Transient Receptor Potential channels (TRP) (type: vgic)
Target: TRPM5

Ligand: APV206690A (Synthetic organic)
Interaction type: Allosteric modulator
Action: Potentiation
Ligand approved: no
Primary target: no
Median affinity: 4.039999961853027 pEC50
Reference (Journal): Identification of positive modulators of TRPM5 channel from a high-throughput screen using a fluorescent membrane potential assay.
Published in: SLAS Discov

Ligand: APV207010A (Synthetic organic)
Interaction type: Allosteric modulator
Action: Potentiation
Ligand approved: no
Primary target: no
Median affinity: 4.420000076293945 pEC50
Reference (Journal): Identification of positive modulators of TRPM5 channel from a high-throughput screen using a fluorescent membrane potential assay.
Published in: SLAS Discov

Ligand: APV207094A (Synthetic organic)
Interaction type: Allosteric modulator
Action: Potentiation
Ligand approved: no
Primary target: no
Median affinity: 4.429999828338623 pEC50
Reference (Journal): Identification of positive modulators of TRPM5 channel from a high-throughput screen using a fluorescent membrane potential assay.
Published in: SLAS Discov

Ligand: APV207095A (Synthetic organic)
Interaction type: Allosteric modulator
Action: Potentiation
Ligand approved: no
Primary target: no
Median affinity: 5.03000020980835 pEC50
Reference (Journal): Identification of positive modulators of TRPM5 channel from a high-throughput screen using a fluorescent membrane potential assay.
Published in: SLAS Discov

Ligand: Ca2+ (Inorganic)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice.
Published in: Cell Calcium

Ligand: Ca2+ (Inorganic)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel.
Published in: Curr Biol

Ligand: Ca2+ (Inorganic)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5.
Published in: Proc Natl Acad Sci USA

Ligand: compound 39 [PMID: 36402081] (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 7.5 pEC50
Reference (Journal): The discovery of (1R, 3R)-1-(3-chloro-5-fluorophenyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile, a potent and selective agonist of human transient receptor potential cation channel subfamily m member 5 (TRPM5) and evaluation of as a potential gastrointestinal prokinetic agent.
Published in: Bioorg Med Chem

Ligand: flufenamic acid (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: yes
Primary target: no
Median affinity: 4.619999885559082 pIC50

Ligand: H+ (Inorganic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 3.200000047683716 pIC50

Ligand: spermine (Metabolite)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 4.429999828338623 pIC50