Target family: Monoamine transporter subfamily (type: transporter)
Target: SERT

Ligand: amitriptyline (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1961)
Primary target: yes
Median affinity: 6.849999904632568 pKi
Reference (Journal): An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'.
Published in: Bioorg Med Chem Lett

Ligand: amoxapine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1980)
Primary target: yes
Median affinity: 7.739999771118164 pKi
Reference (Webpage): National Toxicology Program: Dept of Health and Human Services.

Ligand: atomoxetine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (2002)
Primary target: no
Median affinity: 8.050000190734863 pKd
Reference (Journal): Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group.
Published in: Bioorg Med Chem Lett

Ligand: citalopram (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1998)
Primary target: yes
Median affinity: 8.359999656677246 pKi
Reference (Journal): Carbon-11 labeled indolylpropylamine analog as a new potential PET agent for imaging of the serotonin transporter.
Published in: Bioorg Med Chem

Ligand: clomipramine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1989)
Primary target: yes
Median affinity: 9.680000305175781 pKi
Reference (Journal): Pharmacological profile of antidepressants and related compounds at human monoamine transporters.
Published in: Eur J Pharmacol

Ligand: clomipramine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1989)
Primary target: yes
Median affinity: 9.550000190734863 pKd
Reference (Journal): Pharmacological profile of antidepressants and related compounds at human monoamine transporters.
Published in: Eur J Pharmacol

Ligand: dapoxetine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: UK (2008)
Primary target: yes
Median affinity: 8.949999809265137 pIC50
Reference (Journal): Monoaminergic transporter binding and inhibition profile of dapoxetine, a medication for the treatment of premature ejaculation [abstract].
Published in: J Urol

Ligand: desipramine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (no history prior to 1964)
Primary target: yes
Median affinity: 6.789999961853027 pKi
Reference (Journal): Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.
Published in: J Pharmacol Exp Ther

Ligand: desipramine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (no history prior to 1964)
Primary target: no
Median affinity: 7.699999809265137 pKi
Reference (Journal): Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain.
Published in: J Med Chem

Ligand: desvenlafaxine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (2008)
Primary target: yes
Median affinity: 7.820000171661377 pKi
Reference (Journal): Discovery of a potent, dual serotonin and norepinephrine reuptake inhibitor.
Published in: ACS Med Chem Lett

Ligand: dosulepin (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Primary target: yes
Median affinity: 8.069999694824219 pKi
Reference (Journal): Pharmacological profile of antidepressants and related compounds at human monoamine transporters.
Published in: Eur J Pharmacol

Ligand: doxepin (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1969)
Primary target: yes
Median affinity: 7.170000076293945 pKi
Reference (Journal): Pharmacological profile of antidepressants and related compounds at human monoamine transporters.
Published in: Eur J Pharmacol

Ligand: escitalopram (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (2002)
Primary target: yes
Median affinity: 9 pIC50
Reference (Journal): Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia.
Published in: Bioorg Med Chem Lett

Ligand: escitalopram (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (2002)
Primary target: yes
Median affinity: 8.680000305175781 pKd
Reference (Journal): X-ray structures and mechanism of the human serotonin transporter.
Published in: Nature

Ligand: fluoxetine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1987)
Primary target: yes
Median affinity: 8.5 pKi
Reference (Journal): Pharmacological profile of antidepressants and related compounds at human monoamine transporters.
Published in: Eur J Pharmacol

Ligand: fluvoxamine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1994)
Primary target: yes
Median affinity: 8.65999984741211 pKd
Reference (Journal): Pharmacological profile of antidepressants and related compounds at human monoamine transporters.
Published in: Eur J Pharmacol

Ligand: fluvoxamine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1994)
Primary target: no
Median affinity: 8.1899995803833 pKi
Reference (Journal): Pharmacological characterization and visualization of the glial serotonin transporter.
Published in: Neurochem Int

Ligand: H05 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.319999694824219 pKi
Reference (Journal): Pharmacological Characterization of H05, a Novel Serotonin and Noradrenaline Reuptake Inhibitor with Moderate 5-HT<sub>2A</sub> Antagonist Activity for the Treatment of Depression.
Published in: J Pharmacol Exp Ther

Ligand: ibogaine (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.300000190734863 pIC50
Reference (Journal): Ibogaine and Their Analogs as Therapeutics for Neurological and Psychiatric Disorders.
Published in: ACS Med Chem Lett