Target family: Taste 2 receptors (type: gpcr)
Target: <i>TAS2R14</i>

Ligand: vanillin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 3.240000009536743 pEC50
Reference (Journal): Vanillin Activates Human Bitter Taste Receptors TAS2R14, TAS2R20, and TAS2R39.
Published in: Front Nutr

Ligand: tributyrin (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.489999771118164 pEC50
Reference (Journal): The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14.
Published in: FASEB J

Ligand: silibinin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.25 pEC50
Reference (Journal): Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39.
Published in: J Agric Food Chem

Ligand: santonin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.039999961853027 pEC50
Reference (Journal): Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14.
Published in: Biochim Biophys Acta Gen Subj

Ligand: resveratrol (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.519999980926514 pEC50
Reference (Journal): Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39.
Published in: J Agric Food Chem

Ligand: quinine (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: yes
Approval source: FDA (2005, as quinine sulfate, previous history unspecified)
Primary target: no
Median affinity:  -
Reference (Journal): The molecular receptive ranges of human TAS2R bitter taste receptors.
Published in: Chem Senses

Ligand: (±)-Equol (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.329999923706055 pEC50
Reference (Journal): Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39.
Published in: J Agric Food Chem

Ligand: picrotoxinin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.739999771118164 pEC50
Reference (Journal): The human taste receptor hTAS2R14 responds to a variety of different bitter compounds.
Published in: Biochem Biophys Res Commun

Ligand: phloretin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.519999980926514 pEC50
Reference (Journal): Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39.
Published in: J Agric Food Chem

Ligand: parthenolide (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.989999771118164 pEC50
Reference (Journal): Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14.
Published in: Biochim Biophys Acta Gen Subj

Ligand: N-octanoyl-L-homoserine lactone (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.710000038146973 pEC50
Reference (Journal): Characterization of the Binding Sites for Bacterial Acyl Homoserine Lactones (AHLs) on Human Bitter Taste Receptors (T2Rs).
Published in: ACS Infect Dis

Ligand: nobiletin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.679999828338623 pEC50
Reference (Journal): Bitter substances from plants used in traditional Chinese medicine exert biased activation of human bitter taste receptors.
Published in: Chem Biol Drug Des

Ligand: luteolin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.21999979019165 pEC50
Reference (Journal): Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39.
Published in: J Agric Food Chem

Ligand: lupulone (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.889999866485596 pIC50
Reference (Journal): Three TAS2R Bitter Taste Receptors Mediate the Psychophysical Responses to Bitter Compounds of Hops (Humulus lupulus L.) and Beer
Published in: Chemosensory Perception

Ligand: L-Trp-Trp-Trp (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Amino acids and peptides activate at least five members of the human bitter taste receptor family.
Published in: J Agric Food Chem

Ligand: homoeriodictyol (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.190000057220459 pEC50
Reference (Journal): Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39.
Published in: J Agric Food Chem

Ligand: genistein (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.190000057220459 pEC50
Reference (Journal): Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14.
Published in: Biochim Biophys Acta Gen Subj

Ligand: flufenamic acid (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: yes
Primary target: no
Median affinity: 6.619999885559082 pEC50
Reference (Journal): Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Published in: Nature

Ligand: flufenamic acid (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: yes
Primary target: no
Median affinity: 6.619999885559082 pEC50
Reference (Journal): Rational design of agonists for bitter taste receptor TAS2R14: from modeling to bench and back.
Published in: Cell Mol Life Sci

Ligand: eriodictyol chalcone (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.389999866485596 pEC50
Reference (Journal): Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39.
Published in: J Agric Food Chem

Ligand: (+/-)-Eriodictyol (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.210000038146973 pEC50
Reference (Journal): Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39.
Published in: J Agric Food Chem

Ligand: datiscetin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5 pEC50
Reference (Journal): Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39.
Published in: J Agric Food Chem

Ligand: coumestrol (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 3.450000047683716 pEC50
Reference (Journal): Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39.
Published in: J Agric Food Chem

Ligand: compound 28.1 [PMID: 36847646] (Synthetic organic)
Interaction type: Allosteric modulator
Action: Positive
Ligand approved: no
Primary target: no
Median affinity: 7.139999866485596 pEC50
Reference (Journal): Discovery of 2-Aminopyrimidines as Potent Agonists for the Bitter Taste Receptor TAS2R14.
Published in: J Med Chem

Ligand: aristolochic acid (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 6.309999942779541 pEC50
Reference (Journal): Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14.
Published in: Biochim Biophys Acta Gen Subj

Ligand: aristolochic acid (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 6.309999942779541 pEC50
Reference (Journal): Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Published in: Nature

Ligand: (-)-α-thujone (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.820000171661377 pEC50
Reference (Journal): The human taste receptor hTAS2R14 responds to a variety of different bitter compounds.
Published in: Biochem Biophys Res Commun