Target family: SLC15 family of peptide transporters (type: transporter)
Target: Peptide transporter 2

Ligand: (3,5)-[19F]2-Phe-ψ-Ala (Peptide)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Possible utility of peptide-transporter-targeting [<sup>19</sup>F]dipeptides for visualization of the biodistribution of cancers by nuclear magnetic resonance imaging.
Published in: Int J Pharm

Ligand: 4-AMBA (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 2.5 pKi
Reference (Journal): The renal type H+/peptide symporter PEPT2: structure-affinity relationships.
Published in: Amino Acids

Ligand: 4-AMBA (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 2.5 pKi
Reference (Journal): Synthesis and characterization of high affinity inhibitors of the H+/peptide transporter PEPT2.
Published in: J Biol Chem

Ligand: Ac-[13C,15N]PGP (Peptide)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): A mechanism for matrikine regulation in acute inflammatory lung injury.
Published in: JCI Insight

Ligand: Lys[Z(NO2)]-Lys[Z(NO2)] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8 pKi
Reference (Journal): Synthesis and characterization of high affinity inhibitors of the H+/peptide transporter PEPT2.
Published in: J Biol Chem

Ligand: Lys[Z(NO2)]-Lys[Z(NO2)] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8 pKi
Reference (Journal): The renal type H+/peptide symporter PEPT2: structure-affinity relationships.
Published in: Amino Acids

Ligand: Lys[Z(NO2)]-Pro (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.199999809265137 pKi
Reference (Journal): The renal type H+/peptide symporter PEPT2: structure-affinity relationships.
Published in: Amino Acids

Ligand: Lys[Z(NO2)]-Pro (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.199999809265137 pKi
Reference (Journal): Synthesis and characterization of high affinity inhibitors of the H+/peptide transporter PEPT2.
Published in: J Biol Chem

Ligand: Lys[Z(NO2)]-Val (Peptide)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7 pKi
Reference (Journal): Synthesis and characterization of high affinity inhibitors of the H+/peptide transporter PEPT2.
Published in: J Biol Chem

Ligand: Lys[Z(NO2)]-Val (Peptide)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7 pKi
Reference (Journal): The renal type H+/peptide symporter PEPT2: structure-affinity relationships.
Published in: Amino Acids

Ligand: [11C]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): [11C]Glycylsarcosine: synthesis and in vivo evaluation as a PET tracer of PepT2 transporter function in kidney of PepT2 null and wild-type mice.
Published in: Bioorg Med Chem

Ligand: [14C]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.
Published in: Eur J Pharm Biopharm

Ligand: [14C]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2.
Published in: Eur J Pharmacol

Ligand: [14C]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Functional characterization of brain peptide transporter in rat cerebral cortex: identification of the high-affinity type H+/peptide transporter PEPT2.
Published in: Brain Res

Ligand: [14C]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Effects of glibenclamide on glycylsarcosine transport by the rat peptide transporters PEPT1 and PEPT2.
Published in: Br J Pharmacol

Ligand: [14C]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney.
Published in: Biochim Biophys Acta

Ligand: [14C]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): High-affinity interaction of sartans with H+/peptide transporters.
Published in: Drug Metab Dispos

Ligand: [14C]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells.
Published in: Am J Physiol

Ligand: [14C]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2.
Published in: J Biol Chem

Ligand: [14C]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Divergent developmental expression and function of the proton-coupled oligopeptide transporters PepT2 and PhT1 in regional brain slices of mouse and rat.
Published in: J Neurochem

Ligand: [14C]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2.
Published in: Biochim Biophys Acta

Ligand: [14C]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2.
Published in: Biochem Biophys Res Commun

Ligand: [14C]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited.
Published in: J Pharmacol Exp Ther

Ligand: [14C]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Recognition and transport characteristics of nonpeptidic compounds by basolateral peptide transporter in Caco-2 cells.
Published in: J Pharmacol Exp Ther

Ligand: [18F]FEPPG (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): The Radiolabeling of a Gly-Sar Dipeptide Derivative with Flourine-18 and Its Use as a Potential Peptide Transporter PET Imaging Agent.
Published in: Molecules

Ligand: [3H]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters.
Published in: Drug Metab Dispos

Ligand: [3H]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Effects of frequently used pharmaceutical excipients on the organic cation transporters 1-3 and peptide transporters 1/2 stably expressed in MDCKII cells.
Published in: Eur J Pharm Biopharm

Ligand: [3H]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Expression profile and functional activity of peptide transporters in prostate cancer cells.
Published in: Mol Pharm

Ligand: [3H]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins.
Published in: J Antimicrob Chemother

Ligand: [3H]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Species Differences in Human and Rodent PEPT2-Mediated Transport of Glycylsarcosine and Cefadroxil in Pichia Pastoris Transformants.
Published in: Drug Metab Dispos

Ligand: [3H]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Molecular mechanism of dipeptide and drug transport by the human renal H+/oligopeptide cotransporter hPEPT2.
Published in: Am J Physiol Renal Physiol

Ligand: [3H]mirogabalin (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Mirogabalin, a novel &#x3b1;<sub>2</sub>&#x3b4; ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K.
Published in: Xenobiotica