Target family: Lanosterol biosynthesis pathway (type: enzyme)
Target: squalene synthase

Ligand: 1-allyl-2-[3-(isopropylamino)propoxy]-9H-carbazole (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.489999771118164 pIC50
Reference (Journal): Synthesis and biological evaluation of novel propylamine derivatives as orally active squalene synthase inhibitors.
Published in: Bioorg Med Chem

Ligand: 1-allyl-2-[3-(isopropylamino)propoxy]-9H-carbazole (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.179999828338623 pIC50
Reference (Journal): Synthesis and biological evaluation of novel propylamine derivatives as orally active squalene synthase inhibitors.
Published in: Bioorg Med Chem

Ligand: 1-allyl-2-[3-(isopropylamino)propoxy]-9H-xanthen-9-one (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.920000076293945 pIC50
Reference (Journal): Synthesis and biological evaluation of novel propylamine derivatives as orally active squalene synthase inhibitors.
Published in: Bioorg Med Chem

Ligand: 1-allyl-2-[3-(isopropylamino)propoxy]-9H-xanthen-9-one (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.920000076293945 pIC50
Reference (Journal): Synthesis and biological evaluation of novel propylamine derivatives as orally active squalene synthase inhibitors.
Published in: Bioorg Med Chem

Ligand: BPH-830 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.28000020980835 pKi
Reference (Journal): Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.
Published in: J Med Chem

Ligand: compound 10 [PMID: 18754614] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.300000190734863 pIC50
Reference (Journal): Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity.
Published in: J Med Chem

Ligand: compound 11 [PMID: 7473541] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 5.85 pIC50
Reference (Journal): Phenoxypropylamines: a new series of squalene synthase inhibitors.
Published in: J Med Chem

Ligand: compound 12 [PMID: 20299227] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 4.75 pIC50
Reference (Journal): Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs).
Published in: Bioorg Med Chem

Ligand: compound 12 [Wattanasin et al.,1997] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.64 pIC50
Reference (Journal): N-Hydroxyglycine derivatives as novel inhibitors of squalene synthase.
Published in: Bioorg Med Chem Lett

Ligand: compound 12 [Wattanasin et al.,1997] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.77 pIC50
Reference (Journal): N-Hydroxyglycine derivatives as novel inhibitors of squalene synthase.
Published in: Bioorg Med Chem Lett

Ligand: compound 13 [PMID: 19456099] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.28 pKi
Reference (Journal): Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.
Published in: J Med Chem

Ligand: compound 14 [PMID: 19191557] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 5.43 pIC50
Reference (Journal): Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus.
Published in: J Med Chem

Ligand: compound 14 [PMID: 9871507] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.62 pIC50
Reference (Journal): Cyclopentanedi- and tricarboxylic acids as squalene synthase inhibitors: syntheses and evaluation.
Published in: Bioorg Med Chem Lett

Ligand: compound 15a [PMID: 22464687] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.899999618530273 pIC50
Reference (Journal): Discovery of novel tricyclic compounds as squalene synthase inhibitors.
Published in: Bioorg Med Chem

Ligand: compound 15 [Biller et al., 1993] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.9 pIC50
Reference (Journal): Aromatic isosteres as conformational probes for an isoprenyl subunit: application to inhibitors of squalene synthase.
Published in: Bioorg Med Chem Lett

Ligand: compound 15 [PMID: 19456099] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.52 pKi
Reference (Journal): Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.
Published in: J Med Chem

Ligand: compound 15 [PMID: 8709131] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.4 pIC50
Reference (Journal): Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors.
Published in: J Med Chem

Ligand: compound 16a [Sharratt et al., 1994] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.96 pIC50
Reference (Journal): Structurally simplified squalestatins: monocyclic 1,3-dioxane analogues.
Published in: Bioorg Med Chem Lett

Ligand: compound 17 [PMID: 18754614] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 5.22 pIC50
Reference (Journal): Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity.
Published in: J Med Chem

Ligand: compound 17 [PMID: 8709131] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.3 pIC50
Reference (Journal): Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors.
Published in: J Med Chem

Ligand: compound 17 [Shechter et al., 1996] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 5.7 pIC50
Reference (Journal): Sulfobetaine zwitterionic inhibitors of squalene synthase.
Published in: Bioorg Med Chem Lett

Ligand: compound 18 [PMID: 18754614] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 5.4 pIC50
Reference (Journal): Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity.
Published in: J Med Chem

Ligand: compound 19 [PMID: 18754614] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 5.52 pIC50
Reference (Journal): Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity.
Published in: J Med Chem

Ligand: compound 19 [PMID: 19191557] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 4.93 pIC50
Reference (Journal): Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus.
Published in: J Med Chem

Ligand: compound 19 [PMID: 7473541] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 10.3 pIC50
Reference (Journal): Phenoxypropylamines: a new series of squalene synthase inhibitors.
Published in: J Med Chem

Ligand: compound 1c [Brown et al., 1997] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.37 pKi
Reference (Journal): Novel optimised quinuclidine squalene synthase inhibitors.
Published in: Bioorg Med Chem Lett

Ligand: compound 1e [Brown et al., 1997] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.7 pKi
Reference (Journal): Novel optimised quinuclidine squalene synthase inhibitors.
Published in: Bioorg Med Chem Lett

Ligand: compound 1 [Overhand et al., 1997] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.74 pIC50
Reference (Journal): Synthesis of triphosphonate analogues of farnesyl pyrophosphate. Inhibitors of squalene synthase and protein:farnesyl transferase.
Published in: Bioorg Med Chem Lett

Ligand: compound 1 [PMID: 8496942] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.199999809265137 pIC50
Reference (Journal): Amidinium cation as a mimic of allylic carbocation: synthesis and squalene synthetase inhibitory activity of an amidinium analog of a carbocation intermediate.
Published in: J Med Chem

Ligand: compound 1 [PMID: 8496942] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7 pIC50
Reference (Journal): Amidinium cation as a mimic of allylic carbocation: synthesis and squalene synthetase inhibitory activity of an amidinium analog of a carbocation intermediate.
Published in: J Med Chem

Ligand: compound 20 [PMID: 20299227] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 5.43 pIC50
Reference (Journal): Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs).
Published in: Bioorg Med Chem

Ligand: compound 20 [PMID: 7473541] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 9.22 pIC50
Reference (Journal): Phenoxypropylamines: a new series of squalene synthase inhibitors.
Published in: J Med Chem

Ligand: compound 20 [Shechter et al., 1996] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 5.3 pIC50
Reference (Journal): Sulfobetaine zwitterionic inhibitors of squalene synthase.
Published in: Bioorg Med Chem Lett

Ligand: compound 21 [PMID: 19191557] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.3 pIC50
Reference (Journal): Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus.
Published in: J Med Chem

Ligand: compound 21 [PMID: 7473541] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 11.399999618530273 pIC50
Reference (Journal): Phenoxypropylamines: a new series of squalene synthase inhibitors.
Published in: J Med Chem

Ligand: compound 23 [PMID: 8709131] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.52 pIC50
Reference (Journal): Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors.
Published in: J Med Chem

Ligand: compound 28 [PMID: 7473541] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 9.7 pIC50
Reference (Journal): Phenoxypropylamines: a new series of squalene synthase inhibitors.
Published in: J Med Chem

Ligand: compound 2a (+) [PMID: 8709131] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.15 pIC50
Reference (Journal): Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors.
Published in: J Med Chem

Ligand: compound 2d [PMID: 7629799] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.59 pIC50
Reference (Journal): 1,1-Bisphosphonate squalene synthase inhibitors: interplay between the isoprenoid subunit and the diphosphate surrogate.
Published in: J Med Chem

Ligand: compound 2e [PMID: 7629799] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.6 pIC50
Reference (Journal): 1,1-Bisphosphonate squalene synthase inhibitors: interplay between the isoprenoid subunit and the diphosphate surrogate.
Published in: J Med Chem

Ligand: compound 32 [PMID: 19191557] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.7 pIC50
Reference (Journal): Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus.
Published in: J Med Chem

Ligand: compound 35 [PMID: 19191557] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.4 pIC50
Reference (Journal): Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus.
Published in: J Med Chem

Ligand: compound 3a [PMID: 12238936] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.82 pIC50
Reference (Journal): Synthesis of novel 4,1-benzoxazepine derivatives as squalene synthase inhibitors and their inhibition of cholesterol synthesis.
Published in: J Med Chem

Ligand: compound 3f [PMID: 12238936] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.82 pIC50
Reference (Journal): Synthesis of novel 4,1-benzoxazepine derivatives as squalene synthase inhibitors and their inhibition of cholesterol synthesis.
Published in: J Med Chem

Ligand: compound 3f [PMID: 7966163] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 9.89 pIC50
Reference (Journal): Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives.
Published in: J Med Chem

Ligand: compound 3 [PMID: 19191557] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.52 pIC50
Reference (Journal): Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus.
Published in: J Med Chem

Ligand: compound 4 [Brinkman et al., 1996] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8 pIC50
Reference (Journal): Squalene synthase inhibitors: isosteric replacements of the farnesyl chain of benzyl farnesyl amine.
Published in: Bioorg Med Chem Lett

Ligand: compound 4e [PMID: 7966163] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 10.15 pIC50
Reference (Journal): Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives.
Published in: J Med Chem

Ligand: compound 4g [PMID: 17709461] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.18 pIC50
Reference (Journal): Quinuclidine derivatives as potential antiparasitics.
Published in: Antimicrob Agents Chemother

Ligand: compound 4 [PMID: 18754614] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 5.15 pIC50
Reference (Journal): Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity.
Published in: J Med Chem

Ligand: compound 4 [PMID: 8576905] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.82 pIC50
Reference (Journal): alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase.
Published in: J Med Chem

Ligand: compound 4 [PMID: 8709131] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.96 pIC50
Reference (Journal): Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors.
Published in: J Med Chem

Ligand: compound 4q [PMID: 7650673] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.22 pIC50
Reference (Journal): (Aryloxy)methylsilane derivatives as new cholesterol biosynthesis inhibitors: synthesis and hypocholesterolemic activity of a new class of squalene epoxidase inhibitors.
Published in: J Med Chem

Ligand: compound 5d [PMID: 7966163] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 10.4 pIC50
Reference (Journal): Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives.
Published in: J Med Chem

Ligand: compound 5d [PMID: 7966163] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 10.4 pIC50
Reference (Journal): Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives.
Published in: J Med Chem

Ligand: compound 5j [PMID: 9216829] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.89 pIC50
Reference (Journal): (1 alpha, 2 beta, 3 beta, 4 alpha)-1,2-bis[N-propyl-N-(4-phenoxybenzyl) amino]carbonyl]cyclobutane-3,4-dicarboxylic acid (A-87049): a novel potent squalene synthase inhibitor.
Published in: J Med Chem

Ligand: compound 5m [PMID: 9216829] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.85 pIC50
Reference (Journal): (1 alpha, 2 beta, 3 beta, 4 alpha)-1,2-bis[N-propyl-N-(4-phenoxybenzyl) amino]carbonyl]cyclobutane-3,4-dicarboxylic acid (A-87049): a novel potent squalene synthase inhibitor.
Published in: J Med Chem

Ligand: compound 5 [PMID: 18754614] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 5.3 pIC50
Reference (Journal): Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity.
Published in: J Med Chem

Ligand: compound 6 [Biller et al., 1991] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.43 pKi
Reference (Journal): The First Potent Inhibitor of Squalene Synthase: A Profound Contribution of an Ether Oxygen to Inhibitor-Enzyme Interaction.
Published in: J Am Chem Soc

Ligand: compound 6c [PMID: 7966163] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 9.92 pIC50
Reference (Journal): Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives.
Published in: J Med Chem

Ligand: compound 6d [PMID: 7966163] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 10.05 pIC50
Reference (Journal): Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives.
Published in: J Med Chem

Ligand: compound 6g [PMID: 7966163] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 10.22 pIC50
Reference (Journal): Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives.
Published in: J Med Chem

Ligand: compound 6 [PMID: 7629799] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 9.15 pIC50
Reference (Journal): alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase.
Published in: J Med Chem

Ligand: compound 6 [PMID: 7629799] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 9.15 pIC50
Reference (Journal): 1,1-Bisphosphonate squalene synthase inhibitors: interplay between the isoprenoid subunit and the diphosphate surrogate.
Published in: J Med Chem

Ligand: compound 6 [PMID: 7629799] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 9 pIC50
Reference (Journal): Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus.
Published in: J Med Chem

Ligand: compound 7 [Brinkman et al., 1996] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.05 pIC50
Reference (Journal): Squalene synthase inhibitors: isosteric replacements of the farnesyl chain of benzyl farnesyl amine.
Published in: Bioorg Med Chem Lett

Ligand: compound 7 [PMID: 18754614] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 5.15 pIC50
Reference (Journal): Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity.
Published in: J Med Chem

Ligand: compound 7 [PMID: 8496919] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.4 pIC50
Reference (Journal): N-(arylalkyl)farnesylamines: new potent squalene synthetase inhibitors.
Published in: J Med Chem

Ligand: compound 8 [Brinkman et al., 1996] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.050000190734863 pIC50
Reference (Journal): Squalene synthase inhibitors: isosteric replacements of the farnesyl chain of benzyl farnesyl amine.
Published in: Bioorg Med Chem Lett

Ligand: compound 8 [PMID: 18754614] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 5.7 pIC50
Reference (Journal): Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity.
Published in: J Med Chem

Ligand: compound 8 [PMID: 19191557] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.52 pIC50
Reference (Journal): Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus.
Published in: J Med Chem

Ligand: compound 9 [PMID: 18754614] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6 pIC50
Reference (Journal): Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity.
Published in: J Med Chem

Ligand: CP-294838 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.89 pIC50
Reference (Journal): Truncation of human squalene synthase yields active, crystallizable protein.
Published in: Arch Biochem Biophys

Ligand: E5700 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.82 pIC50
Reference (Journal): Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives.
Published in: Antimicrob Agents Chemother

Ligand: ibandronic acid (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: EMA (1996)
Median affinity: 6.19 pIC50
Reference (Journal): Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs).
Published in: Bioorg Med Chem

Ligand: J-104118 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 9.14 pIC50
Reference (Journal): Synthesis and biological activity of J-104,118, a novel, potent inhibitor of squalene synthase.
Published in: Bioorg Med Chem Lett

Ligand: J-104118 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 9.28 pIC50
Reference (Journal): Synthesis and biological activity of J-104,118, a novel, potent inhibitor of squalene synthase.
Published in: Bioorg Med Chem Lett

Ligand: J-104123 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.6 pIC50
Reference (Journal): J-104,123, a novel and orally-active inhibitor of squalene synthase: Stereoselective synthesis and cholesterol lowering effects in dogs.
Published in: Bioorg Med Chem Lett

Ligand: L-731120 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.590000152587891 pIC50
Reference (Journal): Isolation, structure determination and squalene synthase activity of L-731,120 and L-731,128, alkyl citrate analogs of zaragozic acids A and B.
Published in: Bioorg Med Chem Lett

Ligand: L-731128 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.12 pIC50
Reference (Journal): Isolation, structure determination and squalene synthase activity of L-731,120 and L-731,128, alkyl citrate analogs of zaragozic acids A and B.
Published in: Bioorg Med Chem Lett

Ligand: L-735021 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 9.85 pIC50
Reference (Journal): Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives.
Published in: J Med Chem

Ligand: NB-598 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.7 pIC50
Reference (Journal): (Aryloxy)methylsilane derivatives as new cholesterol biosynthesis inhibitors: synthesis and hypocholesterolemic activity of a new class of squalene epoxidase inhibitors.
Published in: J Med Chem

Ligand: SQ-109 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.130000114440918 pKi
Reference (Journal): Head-to-head prenyl tranferases: anti-infective drug targets.
Published in: J Med Chem

Ligand: SQ-34919 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 9 pIC50
Reference (Journal): 1,1-Bisphosphonate squalene synthase inhibitors: interplay between the isoprenoid subunit and the diphosphate surrogate.
Published in: J Med Chem

Ligand: SQ-34919 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 9 pIC50
Reference (Journal): alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase.
Published in: J Med Chem

Ligand: YM-75440 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.2 pIC50
Reference (Journal): Synthesis and biological evaluation of novel propylamine derivatives as orally active squalene synthase inhibitors.
Published in: Bioorg Med Chem

Ligand: zaragozic acid A (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 9.600000381469727 pKi
Reference (Journal): Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems.
Published in: Arch Biochem Biophys

Ligand: zaragozic acid A (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 9.15 pIC50
Reference (Journal): Truncation of human squalene synthase yields active, crystallizable protein.
Published in: Arch Biochem Biophys

Ligand: zaragozic acid A (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 10.11 pKi
Reference (Journal): Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.
Published in: Proc Natl Acad Sci USA

Ligand: zaragozic acid B (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 10.5 pKi
Reference (Journal): Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.
Published in: Proc Natl Acad Sci USA

Ligand: zaragozic acid C (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 10.4 pKi
Reference (Journal): Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.
Published in: Proc Natl Acad Sci USA

Ligand: zaragozic acid C (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 10.4 pKi
Reference (Journal): The Isolation and Structure Elucidation of Zaragozic Acid C, a Novel Potent Squalene Synthase Inhibitor.
Published in: Tetrahedron