Target family: Chemokine receptors (type: gpcr)
Target: CXCR3

Ligand: ACT-660602 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 8.569999694824219 pIC50
Reference (Journal): Discovery and <i>In Vivo</i> Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine Receptor CXCR3 for Autoimmune Diseases.
Published in: J Med Chem

Ligand: ACT-777991 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 8.34000015258789 pKd
Reference (Journal): Discovery of Clinical Candidate ACT-777991, a Potent CXCR3 Antagonist for Antigen-Driven and Inflammatory Pathologies.
Published in: J Med Chem

Ligand: ACT-777991 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 8.479999542236328 pIC50
Reference (Journal): Discovery of Clinical Candidate ACT-777991, a Potent CXCR3 Antagonist for Antigen-Driven and Inflammatory Pathologies.
Published in: J Med Chem

Ligand: AMG487 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 8.100000381469727 pIC50
Reference (Journal): Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3.
Published in: Bioorg Med Chem Lett

Ligand: CCL11 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 7.2 pKi
Reference (Journal): Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
Published in: J Biol Chem

Ligand: CCL13 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.2 pKi
Reference (Journal): Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
Published in: J Biol Chem

Ligand: CCL19 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.9 pKi
Reference (Journal): Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
Published in: J Biol Chem

Ligand: CCL20 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.8 pKi
Reference (Journal): Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
Published in: J Biol Chem

Ligand: CCL5 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.4 pKi
Reference (Journal): Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
Published in: J Biol Chem

Ligand: CCL7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 6.6 pKi
Reference (Journal): Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
Published in: J Biol Chem

Ligand: CXCL10 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
Published in: J Biol Chem

Ligand: CXCL10 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist.
Published in: J Pharmacol Exp Ther

Ligand: CXCL11 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist.
Published in: J Pharmacol Exp Ther

Ligand: CXCL12α (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.4 pKi
Reference (Journal): Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
Published in: J Biol Chem

Ligand: CXCL9 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
Published in: J Biol Chem

Ligand: CXCL9 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist.
Published in: J Pharmacol Exp Ther

Ligand: dioscin (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 6.3 pIC50
Reference (Journal): Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3.
Published in: Mol Divers

Ligand: duramycin (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 7 pIC50
Reference (Journal): Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3.
Published in: Mol Divers

Ligand: hypoglaucin A (Natural product)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 5.7 pIC50
Reference (Journal): Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3.
Published in: Mol Divers

Ligand: kallstroemin D (Natural product)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 5.5 pIC50
Reference (Journal): Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3.
Published in: Mol Divers

Ligand: NBI-74330 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist.
Published in: J Pharmacol Exp Ther

Ligand: [125I]CXCL10 (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  -

Ligand: [125I]CXCL11 (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  -