Target family: Sphingosine kinase (type: enzyme)
Target: sphingosine kinase 1

Ligand: compound 27d [PMID: 28231433] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.010000228881836 pIC50
Reference (Journal): Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits.
Published in: J Med Chem

Ligand: compound 28 [PMID: 35439002] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.71999979019165 pIC50
Reference (Journal): Novel Sphingosine Kinase 1 Inhibitor Suppresses Growth of Solid Tumor and Inhibits the Lung Metastasis of Triple-Negative Breast Cancer.
Published in: J Med Chem

Ligand: compound 49 [PMID: 30889352] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 7.849999904632568 pIC50
Reference (Journal): Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2.
Published in: J Med Chem

Ligand: compound 55 [PMID: 30889352] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.380000114440918 pIC50
Reference (Journal): Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2.
Published in: J Med Chem

Ligand: compound 59 [PMID: 30889352] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.119999885559082 pIC50
Reference (Journal): Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2.
Published in: J Med Chem

Ligand: compound 60 [PMID: 30889352] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.630000114440918 pIC50
Reference (Journal): Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2.
Published in: J Med Chem

Ligand: MP-A08 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 4.570000171661377 pIC50
Reference (Journal): A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties.
Published in: Oncotarget

Ligand: PF-543 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8.699999809265137 pIC50
Reference (Journal): Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.
Published in: Biochem J

Ligand: PF-543 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8.4399995803833 pKi
Reference (Journal): Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.
Published in: Biochem J

Ligand: PF-543 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8.569999694824219 pIC50
Reference (Journal): Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits.
Published in: J Med Chem

Ligand: SK1-I (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.
Published in: Blood

Ligand: SKI II (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 4.800000190734863 pKi
Reference (Journal): Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2.
Published in: J Pharmacol Exp Ther

Ligand: SKI II (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 6.300000190734863 pIC50
Reference (Journal): Discovery and evaluation of inhibitors of human sphingosine kinase.
Published in: Cancer Res

Ligand: SLM6071469 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.190000057220459 pKi
Reference (Journal): Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity.
Published in: J Med Chem