dwb2023/gtopdb-target-family-interaction-detail huggingface dataset:
Target family: M12: Astacin/Adamalysin (type: enzyme)
Target: ADAM17

Ligand: apratastat (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.7 pIC50
Reference (Journal): Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates.
Published in: Bioorg Med Chem Lett

Ligand: BMS-561392 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.7 pIC50
Reference (Journal): Current perspective of TACE inhibitors: a review.
Published in: Bioorg Med Chem

Ligand: GI254023X (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 3.2699999809265137 pIC50
Reference (Journal): Improved synthesis of ADAM10 inhibitor GI254023X.
Published in: Neurodegener Dis

Ligand: IK-862 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 9.25 pKi
Reference (Journal): Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
Published in: Bioorg Med Chem

Ligand: ilomastat (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.119999885559082 pIC50
Reference (Journal): Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors.
Published in: Bioorg Med Chem Lett

Ligand: SL422 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.920000076293945 pKi
Reference (Journal): Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.
Published in: J Med Chem
Target family: M12: Astacin/Adamalysin (type: enzyme)
Target: ADAM33

Ligand: IK-862 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.820000171661377 pKi
Reference (Journal): Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
Published in: Bioorg Med Chem

Ligand: INCB3619 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.989999771118164 pIC50
Reference (Journal): Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
Published in: Bioorg Med Chem
Target family: M12: Astacin/Adamalysin (type: enzyme)
Target: ADAM8

Ligand: INCB3619 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6 pIC50
Reference (Journal): Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
Published in: Bioorg Med Chem
Target family: M12: Astacin/Adamalysin (type: enzyme)
Target: ADAM9

Ligand: ilomastat (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 9 pIC50
Reference (Journal): Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors.
Published in: Bioorg Med Chem Lett
Target family: M12: Astacin/Adamalysin (type: enzyme)
Target: ADAMTS1

Ligand: compound 12c [PMID: 16516466] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.110000133514404 pKi
Reference (Journal): Synthesis and structure-activity relationship of a novel, achiral series of TNF-alpha converting enzyme inhibitors.
Published in: Bioorg Med Chem Lett
Target family: M12: Astacin/Adamalysin (type: enzyme)
Target: ADAMTS4

Ligand: compound 15c [PMID: 21536437] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8.920000076293945 pIC50
Reference (Journal): Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis.
Published in: Bioorg Med Chem Lett
Target family: M12: Astacin/Adamalysin (type: enzyme)
Target: ADAMTS5

Ligand: aldumastat (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.71999979019165 pIC50
Reference (Journal): Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis.
Published in: J Med Chem

Ligand: compound 15c [PMID: 21536437] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.699999809265137 pIC50
Reference (Journal): Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis.
Published in: Bioorg Med Chem Lett
Target family: M12: Astacin/Adamalysin (type: enzyme)
Target: ADAM10

Ligand: compound 25 [PMID: 18068976] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 7.800000190734863 pIC50
Reference (Journal): Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations.
Published in: Bioorg Med Chem Lett
Target family: M12: Astacin/Adamalysin (type: enzyme)
Target: ADAMTS7

Ligand: BAY-9835 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.239999771118164 pIC50
Reference (Journal): BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor.
Published in: J Med Chem
Target family: M12: Astacin/Adamalysin (type: enzyme)
Target: ADAM10

Ligand: GI254023X (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 5.28000020980835 pIC50
Reference (Journal): Improved synthesis of ADAM10 inhibitor GI254023X.
Published in: Neurodegener Dis
Target family: M12: Astacin/Adamalysin (type: enzyme)
Target: bone morphogenetic protein 1

Ligand: compound 2 [PMID: 11934595] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.699999809265137 pIC50
Reference (Journal): Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains.
Published in: Bioorg Med Chem Lett
Target family: M13: Neprilysin (type: enzyme)
Target: Endothelin-converting enzyme 1

Ligand: KC-12615 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 5.8 pIC50
Reference (Journal): The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans.
Published in: Life Sci
Target family: M13: Neprilysin (type: enzyme)
Target: Endothelin-converting enzyme 2

Ligand: S136492 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 5.329999923706055 pIC50
Reference (Journal): Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2.
Published in: J Med Chem

Ligand: compound 1 [PMID: 18507370] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 5.190000057220459 pIC50
Reference (Journal): Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2.
Published in: J Med Chem
Target family: M13: Neprilysin (type: enzyme)
Target: Endothelin-converting enzyme 1

Ligand: SM19712 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.380000114440918 pIC50
Reference (Journal): Pharmacological characterization of a novel sulfonylureid-pyrazole derivative, SM-19712, a potent nonpeptidic inhibitor of endothelin converting enzyme.
Published in: Jpn J Pharmacol

Ligand: PD159790 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 5.639999866485596 pKi
Reference (Patent): Quinazolines as inhibitors of endothelin converting enzyme.

Ligand: daglutril (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity:  -

Ligand: compound 22 [PMID: 19899765] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.920000076293945 pKi
Reference (Journal): Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors.
Published in: J Med Chem
Target family: M14: Carboxypeptidase A (type: enzyme)
Target: Carboxypeptidase A1 (pancreatic)

Ligand: compound 1b [PMID: 18078750] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.510000228881836 pKi
Reference (Journal): Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite.
Published in: Bioorg Med Chem Lett

Ligand: S-BMPA (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.109999656677246 pKi
Reference (Journal): Synthesis and inhibitory activity of optically active 2-benzyl-3-mercaptopropanoic acid against carboxypeptidase A.
Published in: Bioorg Med Chem Lett
Target family: M14: Carboxypeptidase A (type: enzyme)
Target: Carboxypeptidase B1 (tissue)

Ligand: compound 3 [PMID: 14640538] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.09000015258789 pIC50
Reference (Journal): Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics.
Published in: J Med Chem

Ligand: compound 4 [PMID: 19954973] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.570000171661377 pKi
Reference (Journal): Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor.
Published in: Bioorg Med Chem Lett
Target family: M14: Carboxypeptidase A (type: enzyme)
Target: Carboxypeptidase B2 (plasma)

Ligand: compound 3 [PMID: 14640538] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.699999809265137 pIC50
Reference (Journal): Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics.
Published in: J Med Chem

Ligand: compound 4 [PMID: 19954973] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8.460000038146973 pKi
Reference (Journal): Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor.
Published in: Bioorg Med Chem Lett

Ligand: SQ-24,798 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.399999618530273 pKi
Reference (Journal): Discovery of potent &amp; selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis.
Published in: J Med Chem

Ligand: UK-396,082 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8 pKi
Reference (Journal): Discovery of potent &amp; selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis.
Published in: J Med Chem
Target family: M14: Carboxypeptidase A (type: enzyme)
Target: Carboxypeptidase M

Ligand: compound 3 [PMID: 14640538] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.889999866485596 pIC50
Reference (Journal): Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics.
Published in: J Med Chem
Target family: M14: Carboxypeptidase A (type: enzyme)
Target: Carboxypeptidase N, polypeptide 1

Ligand: compound 3 [PMID: 14640538] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.769999980926514 pIC50
Reference (Journal): Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics.
Published in: J Med Chem

Ligand: SQ-24,798 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.699999809265137 pKi
Reference (Journal): Discovery of potent &amp; selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis.
Published in: J Med Chem
Target family: M16: Pitrilysin (type: enzyme)
Target: insulin degrading enzyme

Ligand: NTE-1 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8.399999618530273 pIC50
Reference (Journal): Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
Published in: J Biol Chem

Ligand: NTE-2 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 7.739999771118164 pIC50
Reference (Journal): Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
Published in: J Biol Chem

Ligand: quinoline 2 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.699999809265137 pIC50
Reference (Journal): Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
Published in: J Biol Chem
Target family: M17: Leucyl aminopeptidase (type: enzyme)
Target: Leucine aminopeptidase 3

Ligand: bestatin (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 9.220000267028809 pKi
Reference (Journal): Inhibition of bovine lens leucine aminopeptidase by bestatin: number of binding sites and slow binding of this inhibitor.
Published in: Biochemistry

Ligand: bestatin (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 9.220000267028809 pKi
Reference (Journal): The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity.
Published in: J Med Chem
Target family: M18: Aminopeptidase I (type: enzyme)
Target: Aminopeptidase A

Ligand: compound 9 [PMID: 1738140] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 6.289999961853027 pKi
Reference (Journal): alpha-Keto amide inhibitors of aminopeptidases.
Published in: J Med Chem
Target family: M19: Membrane dipeptidase (type: enzyme)
Target: Dipeptidase 1

Ligand: cilastatin (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1985)
Primary target: yes
Median affinity: 5.960000038146973 pKi
Reference (Journal): Inhibition of the mammalian beta-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids.
Published in: J Med Chem
Target family: M1: Aminopeptidase N (type: enzyme)
Target: Aminopeptidase N

Ligand: compound I3 [PMID: 23428964] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 9.460000038146973 pKi
Reference (Journal): Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy.
Published in: Bioorg Med Chem

Ligand: BTB07018 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6 pKi
Reference (Journal): Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN).
Published in: Biochimie

Ligand: BTB07018 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.710000038146973 pKi
Reference (Journal): Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN).
Published in: Biochimie

Ligand: compound 1a [PMID: 25692029] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.539999961853027 pKi
Reference (Journal): Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.
Published in: J Med Chem

Ligand: compound 1a [PMID: 25692029] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.539999961853027 pKi
Reference (Journal): Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain.
Published in: Pharmacol Res Perspect

Ligand: compound I3 [PMID: 23428964] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 9.699999809265137 pKi
Reference (Journal): Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy.
Published in: Bioorg Med Chem

Ligand: JFD00064 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.699999809265137 pKi
Reference (Journal): Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN).
Published in: Biochimie

Ligand: JFD00064 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.539999961853027 pKi
Reference (Journal): Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN).
Published in: Biochimie

Ligand: opiorphin (Peptide)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.099999904632568 pIC50
Reference (Journal): Proposed Bioactive Conformations of Opiorphin, an Endogenous Dual APN/NEP Inhibitor.
Published in: ACS Med Chem Lett
Target family: M1: Aminopeptidase N (type: enzyme)
Target: Arginyl aminopeptidase

Ligand: Lys-thiol (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 9.050000190734863 pKi
Reference (Journal): L-lysinethiol: a subnanomolar inhibitor of aminopeptidase B.
Published in: Biochem Biophys Res Commun
Target family: M1: Aminopeptidase N (type: enzyme)
Target: Endoplasmic reticulum aminopeptidase 1

Ligand: compound 17 [PMID: 23916253] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.590000152587891 pIC50
Reference (Journal): Novel selective inhibitors of aminopeptidases that generate antigenic peptides.
Published in: Bioorg Med Chem Lett

Ligand: compound 2g [PMID: 27390066] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.28000020980835 pKi
Reference (Journal): Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues.
Published in: Bioorg Med Chem Lett

Ligand: compound 3v [PMID: 27390066] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 3.5999999046325684 pKi
Reference (Journal): Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues.
Published in: Bioorg Med Chem Lett
Target family: M1: Aminopeptidase N (type: enzyme)
Target: Endoplasmic reticulum aminopeptidase 2

Ligand: compound 17 [PMID: 23916253] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.050000190734863 pIC50
Reference (Journal): Novel selective inhibitors of aminopeptidases that generate antigenic peptides.
Published in: Bioorg Med Chem Lett

Ligand: compound 2g [PMID: 27390066] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.820000171661377 pKi
Reference (Journal): Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues.
Published in: Bioorg Med Chem Lett

Ligand: compound 3v [PMID: 27390066] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 6.210000038146973 pKi
Reference (Journal): Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues.
Published in: Bioorg Med Chem Lett
Target family: M1: Aminopeptidase N (type: enzyme)
Target: Glutamyl aminopeptidase

Ligand: compound 40 [PMID: 10602705] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 9.0600004196167 pKi
Reference (Journal): Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme.
Published in: J Med Chem
Target family: M1: Aminopeptidase N (type: enzyme)
Target: Leucyl-cysteinyl aminopeptidase

Ligand: compound 17 [PMID: 23916253] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.21999979019165 pIC50
Reference (Journal): Novel selective inhibitors of aminopeptidases that generate antigenic peptides.
Published in: Bioorg Med Chem Lett

Ligand: inhibitor 19 [PMID: 21476495] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8.739999771118164 pKi
Reference (Journal): Potent macrocyclic inhibitors of insulin-regulated aminopeptidase (IRAP) by olefin ring-closing metathesis.
Published in: J Med Chem