Target family: Lysophospholipid (LPA) receptors (type: gpcr)
Target: LPA<sub>5</sub> receptor

Ligand: alkyl glycerol phosphate 18:1 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 8.699999809265137 pEC50
Reference (Journal): Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.
Published in: J Biol Chem

Ligand: AS2717638 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.420000076293945 pIC50
Reference (Journal): Analgesic effects of novel lysophosphatidic acid receptor 5 antagonist AS2717638 in rodents.
Published in: Neuropharmacology

Ligand: compound 65 [PMID: 36126387] (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.199999809265137 pIC50
Reference (Journal): Isoquinolone derivatives as lysophosphatidic acid receptor 5 (LPA5) antagonists: Investigation of structure-activity relationships, ADME properties and analgesic effects.
Published in: Eur J Med Chem

Ligand: compound 66 [PMID: 36126387] (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.5 pIC50
Reference (Journal): Isoquinolone derivatives as lysophosphatidic acid receptor 5 (LPA5) antagonists: Investigation of structure-activity relationships, ADME properties and analgesic effects.
Published in: Eur J Med Chem

Ligand: farnesyl diphosphate (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.
Published in: J Biol Chem

Ligand: farnesyl diphosphate (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92.
Published in: J Biol Chem

Ligand: farnesyl monophosphate (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.31 pEC50
Reference (Journal): Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.
Published in: J Biol Chem

Ligand: LPA (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Synthesis, in vitro structure-activity relationship, and in vivo studies of 2-arylthiazolidine-4-carboxylic acid amides as anticancer agents.
Published in: Bioorg Med Chem

Ligand: LPA (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Screening β-Arrestin Recruitment for the Identification of Natural Ligands for Orphan G-Protein-Coupled Receptors.
Published in: J Biomol Screen

Ligand: LPA (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 8.1899995803833 pKd
Reference (Journal): Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes.
Published in: J Pharmacol Exp Ther

Ligand: LPA (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92.
Published in: J Biol Chem

Ligand: N-arachidonoylglycine (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Primary target: no
Median affinity: 4.300000190734863 pEC50
Reference (Journal): Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92.
Published in: J Biol Chem

Ligand: N-arachidonoylglycine (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Primary target: no
Median affinity: 4.300000190734863 pEC50
Reference (Journal): Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.
Published in: J Biol Chem

Ligand: octyl thiophosphatidic acid (Synthetic organic)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Primary target: no
Median affinity: 5.679999828338623 pEC50
Reference (Journal): Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.
Published in: J Biol Chem

Ligand: TCLPA5 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: yes
Median affinity: 6.099999904632568 pIC50
Reference (Journal): Selective non-lipid modulator of LPA5 activity in human platelets.
Published in: Bioorg Med Chem Lett