Target family: Calcium- and sodium-activated potassium channels (K<sub>Ca</sub>, K<sub>Na</sub>) (type: vgic)
Target: K<sub>Na</sub>1.2

Ligand: tetraethylammonium (Synthetic organic)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Opposite regulation of Slick and Slack K+ channels by neuromodulators.
Published in: J Neurosci

Ligand: tetraethylammonium (Synthetic organic)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Opposite regulation of Slick and Slack K+ channels by neuromodulators.
Published in: J Neurosci

Ligand: quinidine (Natural product)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1950)
Primary target: no
Median affinity:  -
Reference (Journal): Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP.
Published in: J Neurosci

Ligand: phorbol 12-myristate 13-acetate (Synthetic organic)
Interaction type: Gating inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.92 pIC50
Reference (Journal): Opposite regulation of Slick and Slack K+ channels by neuromodulators.
Published in: J Neurosci

Ligand: niflumic acid (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: yes
Primary target: no
Median affinity: 8.680000305175781 pEC50
Reference (Journal): Structure-activity relationship of fenamates as Slo2.1 channel activators.
Published in: Mol Pharmacol

Ligand: niflumic acid (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: yes
Primary target: no
Median affinity: 8.680000305175781 pEC50
Reference (Journal): Activation of Slo2.1 channels by niflumic acid.
Published in: J Gen Physiol

Ligand: Na+ (Inorganic)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP.
Published in: J Neurosci

Ligand: flufenamic acid (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: yes
Primary target: no
Median affinity: 8.850000381469727 pEC50
Reference (Journal): Activation of Slo2.1 channels by niflumic acid.
Published in: J Gen Physiol

Ligand: flufenamic acid (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: yes
Primary target: no
Median affinity: 8.850000381469727 pEC50
Reference (Journal): Structure-activity relationship of fenamates as Slo2.1 channel activators.
Published in: Mol Pharmacol

Ligand: Cl- (Inorganic)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP.
Published in: J Neurosci

Ligand: clofilium (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Clofilium inhibits Slick and Slack potassium channels.
Published in: Biologics

Ligand: Ba2+ (Inorganic)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 3 pIC50
Reference (Journal): Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP.
Published in: J Neurosci

Ligand: ATP (Metabolite)
Interaction type: Gating inhibitor
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP.
Published in: J Neurosci