Target family: Glucagon receptor family (type: gpcr)
Target: secretin receptor

Ligand: VIP (Peptide)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 5.4 pIC50
Reference (Journal): Molecular cloning and expression of a cDNA encoding the secretin receptor.
Published in: EMBO J

Ligand: VIP (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.2 pIC50
Reference (Journal): Development of high affinity selective VIP1 receptor agonists.
Published in: Peptides

Ligand: [125I](Tyr10)secretin-27 (rat) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Cellular distribution of secretin receptor expression in rat pancreas.
Published in: Am J Physiol

Ligand: [125I]secretin (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKd
Reference (Journal): Molecular cloning and expression of a cDNA encoding the secretin receptor.
Published in: EMBO J

Ligand: secretin-(5-27) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5 pIC50
Reference (Journal): Molecular cloning and expression of a cDNA encoding the secretin receptor.
Published in: EMBO J

Ligand: secretin (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9 pIC50
Reference (Journal): Development of high affinity selective VIP1 receptor agonists.
Published in: Peptides

Ligand: secretin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Identification of an interaction between residue 6 of the natural peptide ligand and a distinct residue within the amino-terminal tail of the secretin receptor.
Published in: J Biol Chem

Ligand: secretin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Molecular cloning and expression of a cDNA encoding the secretin receptor.
Published in: EMBO J

Ligand: secretin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: yes
Approval source: FDA (2002)
Primary target: yes
Median affinity: 9.699999809265137 pEC50
Reference (Journal): Molecular cloning and functional characterization of a human secretin receptor.
Published in: Biochem Biophys Res Commun

Ligand: secretin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Protean effects of a natural peptide agonist of the G protein-coupled secretin receptor demonstrated by receptor mutagenesis.
Published in: J Pharmacol Exp Ther

Ligand: [(CH2NH)4,5]secretin (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 5.300000190734863 pKi
Reference (Journal): Reduced peptide bond pseudopeptide analogues of secretin. A new class of secretin receptor antagonists.
Published in: J Biol Chem

Ligand: [Bpa6,Tyr10]secretin-27 (rat) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.6 pKd
Reference (Journal): Identification of an interaction between residue 6 of the natural peptide ligand and a distinct residue within the amino-terminal tail of the secretin receptor.
Published in: J Biol Chem

Ligand: [Arg16]chicken secretin (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.7 pIC50
Reference (Journal): Development of high affinity selective VIP1 receptor agonists.
Published in: Peptides