Target family: Aminoacyl-tRNA synthetases (type: other_protein)
Target: Plasmodium falciparum prolyl-tRNA synthetase

Ligand: compound 1 [PMID: 33929818] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.739999771118164 pIC50
Reference (Journal): Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as <i>Plasmodium</i> Cytoplasmic Prolyl-tRNA Synthetase Inhibitors.
Published in: ACS Infect Dis

Ligand: compound 1 [PMID: 33929818] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.769999980926514 pIC50
Reference (Journal): Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as <i>Plasmodium</i> Cytoplasmic Prolyl-tRNA Synthetase Inhibitors.
Published in: ACS Infect Dis

Ligand: compound 1 [PMID: 33929818] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.739999771118164 pIC50
Reference (Journal): Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as <i>Plasmodium</i> Cytoplasmic Prolyl-tRNA Synthetase Inhibitors.
Published in: ACS Infect Dis

Ligand: compound 1 [PMID: 33929818] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.699999809265137 pIC50
Reference (Journal): Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as <i>Plasmodium</i> Cytoplasmic Prolyl-tRNA Synthetase Inhibitors.
Published in: ACS Infect Dis

Ligand: compound 1 [PMID: 33929818] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.619999885559082 pIC50
Reference (Journal): Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as <i>Plasmodium</i> Cytoplasmic Prolyl-tRNA Synthetase Inhibitors.
Published in: ACS Infect Dis

Ligand: compound 1 [PMID: 33929818] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8 pIC50
Reference (Journal): Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as <i>Plasmodium</i> Cytoplasmic Prolyl-tRNA Synthetase Inhibitors.
Published in: ACS Infect Dis

Ligand: halofuginone (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.769999980926514 pIC50
Reference (Journal): Characterization of Plasmodium liver stage inhibition by halofuginone.
Published in: ChemMedChem

Ligand: halofuginone (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 9.09000015258789 pEC50
Reference (Journal): The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Published in: Sci Transl Med

Ligand: halofuginone (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 9.069999694824219 pEC50
Reference (Journal): The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Published in: Sci Transl Med