Target family: Neuropeptide Y receptors (type: gpcr)
Target: Y<sub>5</sub> receptor

Ligand: [125I][PP1-17,Ala31,Aib32]NPY (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.9 pKd
Reference (Journal): Development and characterization of a highly selective neuropeptide Y Y5 receptor agonist radioligand: [125I][hPP1-17, Ala31, Aib32]NPY.
Published in: Br J Pharmacol

Ligand: [125I][cPP(1-7), NPY(19-23), Ala31, Aib32, Gln34]hPP (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKd
Reference (Journal): Characterization of a new neuropeptide Y Y5 agonist radioligand: [125I][cPP(1-7), NPY(19-23), Ala31, Aib32, Gln34]hPP.
Published in: Neuropeptides

Ligand: PYY-(3-36) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: PYY-(3-36) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.4 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: PYY-(13-36) (mouse, rat, pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.1 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: PYY-(13-36) (mouse, rat, pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.1 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: [PP1-17,Ala31,Aib32]NPY (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.8 pKi
Reference (Journal): Development and characterization of a highly selective neuropeptide Y Y5 receptor agonist radioligand: [125I][hPP1-17, Ala31, Aib32]NPY.
Published in: Br J Pharmacol

Ligand: peptide YY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.9 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: peptide YY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Development and characterization of a highly selective neuropeptide Y Y5 receptor agonist radioligand: [125I][hPP1-17, Ala31, Aib32]NPY.
Published in: Br J Pharmacol

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.5 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.4 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: NPY-(3-36) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: NPY-(3-36) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.7 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: NPY-(2-36) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.9 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: NPY-(2-36) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.9 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: NPY-(18-36) (human, pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.2 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: NPY-(18-36) (human, pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.7 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: NPY-(13-36) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.7 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: NPY-(13-36) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.3 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: neuropeptide Y (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.1 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: neuropeptide Y (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.3 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: [Leu31,Pro34]PYY (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.7 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: [Leu31,Pro34]PYY (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 8.800000190734863 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: [Leu31,Pro34]NPY (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: [Leu31,Pro34]NPY (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.1 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: [Leu31,Pro34]NPY (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Development and characterization of a highly selective neuropeptide Y Y5 receptor agonist radioligand: [125I][hPP1-17, Ala31, Aib32]NPY.
Published in: Br J Pharmacol

Ligand: L-152,804 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.599999904632568 pKi
Reference (Journal): L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist.
Published in: Biochem Biophys Res Commun

Ligand: L-152,804 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 7.5 pKi
Reference (Journal): L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist.
Published in: Biochem Biophys Res Commun

Ligand: JCF 109 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.3 pKi
Reference (Journal): Development and characterization of a highly selective neuropeptide Y Y5 receptor agonist radioligand: [125I][hPP1-17, Ala31, Aib32]NPY.
Published in: Br J Pharmacol

Ligand: GR231118 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.4 pKi
Reference (Journal): Development and characterization of a highly selective neuropeptide Y Y5 receptor agonist radioligand: [125I][hPP1-17, Ala31, Aib32]NPY.
Published in: Br J Pharmacol

Ligand: FMS586 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.4 pIC50
Reference (Journal): Pharmacological characterization and feeding-suppressive property of FMS586 [3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin-4-yl-ethyl)-urea hydrochloride], a novel, selective, and orally active antagonist for neuropeptide Y Y5 receptor.
Published in: J Pharmacol Exp Ther

Ligand: [D-Trp32]NPY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.2 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: [D-Trp32]NPY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.1 pKi
Reference (Journal): Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.
Published in: J Biol Chem

Ligand: CGP 71683A (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 9.5 pKi
Reference (Journal): Development and characterization of a highly selective neuropeptide Y Y5 receptor agonist radioligand: [125I][hPP1-17, Ala31, Aib32]NPY.
Published in: Br J Pharmacol

Ligand: [Ala31,Aib32]NPY (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.2 pIC50
Reference (Journal): Ala31-Aib32: identification of the key motif for high affinity and selectivity of neuropeptide Y at the Y5-receptor.
Published in: Biochemistry

Ligand: [Ala31,Aib32]NPY (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 8.199999809265137 pIC50
Reference (Journal): Ala31-Aib32: identification of the key motif for high affinity and selectivity of neuropeptide Y at the Y5-receptor.
Published in: Biochemistry

Ligand: [Ala31,Aib32]NPY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.4 pKi
Reference (Journal): Development and characterization of a highly selective neuropeptide Y Y5 receptor agonist radioligand: [125I][hPP1-17, Ala31, Aib32]NPY.
Published in: Br J Pharmacol