Target family: Other antimalarial targets (type: other_protein)
Target: Plasmodium falciparum N-myristoyltransferase

Ligand: compound 34c [PMID: 24641010] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.039999961853027 pEC50
Reference (Journal): Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP).
Published in: J Med Chem

Ligand: compound 34c [PMID: 24641010] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.519999980926514 pEC50
Reference (Journal): Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP).
Published in: J Med Chem

Ligand: compound 34c [PMID: 24641010] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.630000114440918 pEC50
Reference (Journal): Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP).
Published in: J Med Chem

Ligand: compound 34c [PMID: 24641010] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.46999979019165 pEC50
Reference (Journal): Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP).
Published in: J Med Chem

Ligand: compound 34c [PMID: 24641010] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.429999828338623 pEC50
Reference (Journal): Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP).
Published in: J Med Chem

Ligand: compound 34c [PMID: 24641010] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8.100000381469727 pKi
Reference (Journal): Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP).
Published in: J Med Chem

Ligand: DDD85646 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.599999904632568 pEC50
Reference (Journal): Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.
Published in: Nat Chem

Ligand: IMP-1002 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.46999979019165 pEC50
Reference (Journal): Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors.
Published in: Cell Chem Biol

Ligand: IMP-1002 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.690000057220459 pEC50
Reference (Journal): Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors.
Published in: Cell Chem Biol