Target family: Free fatty acid receptors (type: gpcr)
Target: FFA4 receptor

Ligand: α-linolenic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.5 pEC50
Reference (Journal): Discovery of a potent and selective GPR120 agonist.
Published in: J Med Chem

Ligand: α-linolenic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 5.059999942779541 pEC50
Reference (Journal): Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells.
Published in: Naunyn Schmiedebergs Arch Pharmacol

Ligand: compound A [PMID 24997608] (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: yes
Median affinity: 7.619999885559082 pEC50
Reference (Journal): A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice.
Published in: Nat Med

Ligand: grifolic acid (Natural product)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 4.95 pA2
Reference (Journal): Novel selective ligands for free fatty acid receptors GPR120 and GPR40.
Published in: Naunyn Schmiedebergs Arch Pharmacol

Ligand: grifolic acid methyl ether (Natural product)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 5.01 pA2
Reference (Journal): Novel selective ligands for free fatty acid receptors GPR120 and GPR40.
Published in: Naunyn Schmiedebergs Arch Pharmacol

Ligand: grifolic acid methyl ether (Natural product)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 5.01 pA2
Reference (Journal): Structure-Activity Relationships of GPR120 Agonists Based on a Docking Simulation.
Published in: Mol Pharmacol

Ligand: GW9508 (Synthetic organic)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Primary target: no
Median affinity: 5.460000038146973 pEC50
Reference (Journal): Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.
Published in: Br J Pharmacol

Ligand: GW9508 (Synthetic organic)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Primary target: no
Median affinity: 5.460000038146973 pEC50
Reference (Journal): Free fatty acid receptors and drug discovery.
Published in: Biol Pharm Bull

Ligand: linoleic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.89 pEC50
Reference (Journal): Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.
Published in: Br J Pharmacol

Ligand: myristic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 5.199999809265137 pEC50
Reference (Journal): Differential signaling by splice variants of the human free fatty acid receptor GPR120.
Published in: Mol Pharmacol

Ligand: NCG21 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.92 pEC50
Reference (Journal): Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists.
Published in: J Med Chem

Ligand: oleic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 4.699999809265137 pEC50
Reference (Journal): Differential signaling by splice variants of the human free fatty acid receptor GPR120.
Published in: Mol Pharmacol