Target family: ChaK subfamily (type: enzyme)
Target: TRPM7

Ligand: 2-APB (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.
Published in: J Gen Physiol

Ligand: 2-APB (Synthetic organic)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 3.75 pIC50
Reference (Journal): Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.
Published in: J Gen Physiol

Ligand: carvacrol (Natural product)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 3.5199999809265137 pIC50
Reference (Journal): Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels.
Published in: Cell Calcium

Ligand: fingolimod (Synthetic organic)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: yes
Approval source: FDA (2010), EMA (2011)
Primary target: no
Median affinity: 6.139999866485596 pIC50
Reference (Journal): Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels.
Published in: Br J Pharmacol

Ligand: H+ (Inorganic)
Interaction type: Activator
Action: Potentiation
Ligand approved: no
Primary target: no
Median affinity: 4.5 pEC50
Reference (Journal): Potentiation of TRPM7 inward currents by protons.
Published in: J Gen Physiol

Ligand: La3+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): TRP-PLIK, a bifunctional protein with kinase and ion channel activities.
Published in: Science

Ligand: Mg2+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 2.490000009536743 pIC50
Reference (Journal): LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability.
Published in: Nature

Ligand: nafamostat (Synthetic organic)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: yes
Approval source: Japan only
Median affinity: 3.21 pIC50
Reference (Journal): The modulation of TRPM7 currents by nafamostat mesilate depends directly upon extracellular concentrations of divalent cations.
Published in: Mol Brain

Ligand: naltriben (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Activation of TRPM7 channels by small molecules under physiological conditions.
Published in: Pflugers Arch

Ligand: NS8593 (Synthetic organic)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Median affinity: 5.8 pIC50
Reference (Journal): Natural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7.
Published in: Br J Pharmacol

Ligand: PIP2 (Metabolite)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  -
Reference (Journal): The TRPM7 channel is inactivated by PIP(2) hydrolysis.
Published in: Nat Cell Biol

Ligand: spermine (Metabolite)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.639999866485596 pKi
Reference (Journal): Distinct properties of CRAC and MIC channels in RBL cells.
Published in: J Gen Physiol

Ligand: sphingosine (Metabolite)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.230000019073486 pIC50
Reference (Journal): Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels.
Published in: Br J Pharmacol

Ligand: waixenicin A (Natural product)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels.
Published in: J Biol Chem