Target family: Leukotriene receptors (type: gpcr)
Target: BLT<sub>2</sub> receptor

Ligand: [3H]LTB4 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Median affinity:  pKd

Ligand: LY255283 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones.
Published in: J Med Chem

Ligand: LY255283 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2.
Published in: J Biol Chem

Ligand: LTB4 (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 7.64 pKd
Reference (Journal): A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders.
Published in: J Exp Med

Ligand: LTB4 (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 6.85 pEC50
Reference (Journal): 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2.
Published in: J Exp Med

Ligand: LTB4 (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 7.6 pIC50
Reference (Journal): 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2.
Published in: J Exp Med

Ligand: CP-195543 (Synthetic organic)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 5 pEC50
Reference (Journal): Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2.
Published in: J Biol Chem

Ligand: CP-195543 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 6 pIC50
Reference (Journal): Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2.
Published in: J Biol Chem

Ligand: CAY10583 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.52 pKi
Reference (Journal): Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes.
Published in: J Biol Chem

Ligand: CAY10583 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.7 pEC50
Reference (Journal): Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes.
Published in: J Biol Chem

Ligand: 15S-HETE (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 7.52 pEC50
Reference (Journal): Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2.
Published in: J Biol Chem

Ligand: 12S-HETE (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Primary target: no
Median affinity: 7.519999980926514 pEC50
Reference (Journal): Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2.
Published in: J Biol Chem

Ligand: 12-hydroxyheptadecatrienoic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.72 pEC50
Reference (Journal): 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2.
Published in: J Exp Med

Ligand: 12-hydroxyheptadecatrienoic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.55 pIC50
Reference (Journal): 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2.
Published in: J Exp Med

Ligand: 12-epi LTB4 (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 7.52 pEC50
Reference (Journal): Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2.
Published in: J Biol Chem