Target family: GABA<sub>B</sub> receptors (type: gpcr)
Target: GABA<sub>B1</sub>

Ligand: lesogaberan (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: yes
Median affinity: 8.100000381469727 pEC50
Reference (Webpage): Lesogaberan (AZD3355).

Ligand: GABA (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Published in: Nature

Ligand: CGP 71872 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Published in: Nature

Ligand: CGP 64213 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Published in: Nature

Ligand: CGP 62349 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Published in: Nature

Ligand: CGP 56999A (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Published in: Nature

Ligand: CGP 54626A (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Published in: Nature

Ligand: CGP 47656 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Published in: Nature

Ligand: CGP 35348 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists.
Published in: J Med Chem

Ligand: CGP 35348 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Published in: Nature

Ligand: (-)-baclofen (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Published in: Nature

Ligand: 3-APPA (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.599999904632568 pIC50
Reference (Journal): Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Published in: Nature

Ligand: 2-hydroxy-saclofen (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 4.1 pIC50
Reference (Journal): Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Published in: Nature