Target family: Class A Orphans (type: gpcr)
Target: <i>GPR183</i>

Ligand: NIBR51 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.650000095367432 pEC50
Reference (Journal): Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor.
Published in: J Med Chem

Ligand: NIBR51 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.650000095367432 pEC50
Reference (Journal): Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor.
Published in: J Med Chem

Ligand: NIBR189 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.960000038146973 pIC50
Reference (Journal): Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor.
Published in: J Med Chem

Ligand: NIBR189 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.820000171661377 pIC50
Reference (Journal): Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor.
Published in: J Med Chem

Ligand: GSK682753A (Synthetic organic)
Interaction type: Agonist
Action: Inverse agonist
Ligand approved: no
Primary target: no
Median affinity: 7.269999980926514 pIC50
Reference (Journal): Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist.
Published in: J Biol Chem

Ligand: GSK682753A (Synthetic organic)
Interaction type: Agonist
Action: Inverse agonist
Ligand approved: no
Primary target: no
Median affinity: 8.59000015258789 pIC50
Reference (Journal): Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist.
Published in: J Biol Chem

Ligand: compound 32 [PMID: 38047891] (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 8.069999694824219 pIC50
Reference (Journal): Discovery of a First-in-Class GPR183 Antagonist for the Potential Treatment of Rheumatoid Arthritis.
Published in: J Med Chem

Ligand: 7β-hydroxycholesterol (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 5.75 pEC50
Reference (Journal): Oxysterols direct B-cell migration through EBI2.
Published in: Nature

Ligand: 7β, 27-dihydroxycholesterol (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.29 pEC50
Reference (Journal): Oxysterols direct B-cell migration through EBI2.
Published in: Nature

Ligand: 7β, 25-dihydroxycholesterol (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.68 pEC50
Reference (Journal): Oxysterols direct B-cell migration through EBI2.
Published in: Nature

Ligand: 7α-hydroxycholesterol (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.09 pEC50
Reference (Journal): Oxysterols direct B-cell migration through EBI2.
Published in: Nature

Ligand: 7α,27-dihydroxycholesterol (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.89 pEC50
Reference (Journal): Oxysterols direct B-cell migration through EBI2.
Published in: Nature

Ligand: 7α,25-dihydroxycholesterol (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Oxysterols direct immune cell migration via EBI2.
Published in: Nature

Ligand: 7α,25-dihydroxycholesterol (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Oxysterols direct immune cell migration via EBI2.
Published in: Nature

Ligand: 7α,25-dihydroxycholesterol (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Oxysterols direct B-cell migration through EBI2.
Published in: Nature

Ligand: 7α,25-dihydroxycholesterol (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Oxysterols direct B-cell migration through EBI2.
Published in: Nature

Ligand: 27-hydroxycholesterol (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 5.52 pEC50
Reference (Journal): Oxysterols direct B-cell migration through EBI2.
Published in: Nature

Ligand: 25-hydroxycholesterol (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.9 pEC50
Reference (Journal): Oxysterols direct B-cell migration through EBI2.
Published in: Nature