Target family: Hydroxycarboxylic acid receptors (type: gpcr)
Target: HCA<sub>3</sub> receptor

Ligand: nicotinic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Molecular identification of high and low affinity receptors for nicotinic acid.
Published in: J Biol Chem

Ligand: IBC 293 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 6.400000095367432 pEC50
Reference (Journal): 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b.
Published in: J Med Chem

Ligand: D-tryptophan (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.01 pEC50
Reference (Journal): Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B.
Published in: Proc Natl Acad Sci USA

Ligand: D-phenyllactic acid (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 6.820000171661377 pEC50
Reference (Journal): Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3.
Published in: PLoS Genet

Ligand: D-phenylalanine (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.04 pEC50
Reference (Journal): Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B.
Published in: Proc Natl Acad Sci USA

Ligand: D-kynurenine (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.58 pEC50
Reference (Journal): Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B.
Published in: Proc Natl Acad Sci USA

Ligand: compound 6o [PMID: 19524438] (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 8.520000457763672 pEC50
Reference (Journal): 5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b.
Published in: Bioorg Med Chem Lett

Ligand: compound 5b [PMID: 17358052] (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.3 pEC50
Reference (Journal): Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b.
Published in: J Med Chem

Ligand: acifran (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Molecular identification of high and low affinity receptors for nicotinic acid.
Published in: J Biol Chem

Ligand: acifran (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Triglyceride modulation by acifran analogs: activity towards the niacin high and low affinity G protein-coupled receptors HM74A and HM74.
Published in: Biochem Biophys Res Commun

Ligand: acifran (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b.
Published in: J Med Chem

Ligand: acifran (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): (D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G.
Published in: J Biol Chem

Ligand: 5-methyl-5-(5-methylthiophen-3-yl)-4-oxo-4,5-dihydrofuran-2-carboxylic acid (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.7 pEC50
Reference (Journal): Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b.
Published in: J Med Chem

Ligand: 4-(n-propyl)amino-3-nitrobenzoic acid (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.52 pEC50
Reference (Journal): 3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b.
Published in: Bioorg Med Chem Lett

Ligand: 3-hydroxyoctanoic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.1 pEC50
Reference (Journal): Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis.
Published in: J Biol Chem

Ligand: 2-hydroxyoctanoic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.4 pEC50
Reference (Journal): Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis.
Published in: J Biol Chem