Target family: Transient Receptor Potential channels (TRP) (type: vgic)
Target: TRPV3

Ligand: 2-APB (Synthetic organic)
Interaction type: Activator
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 4.599999904632568 pEC50
Reference (Journal): 2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3.
Published in: J Neurosci

Ligand: 6-tert-butyl-m-cresol (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 3.430000066757202 pEC50
Reference (Journal): Monoterpenoid agonists of TRPV3.
Published in: Br J Pharmacol

Ligand: aspirin-triggered resolvin D1 (Metabolite)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Median affinity: 6.4 pIC50
Reference (Journal): 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception.
Published in: Br J Pharmacol

Ligand: borneol (Natural product)
Interaction type: Activator
Action: Activation
Ligand approved: no
Median affinity: 2.46 pEC50
Reference (Journal): Monoterpenoid agonists of TRPV3.
Published in: Br J Pharmacol

Ligand: camphor (Natural product)
Interaction type: Activator
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 2 pEC50
Reference (Journal): Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin.
Published in: Science

Ligand: cannabidiol (Natural product)
Interaction type: Activator
Action: Activation
Ligand approved: yes
Approval source: FDA (2018), EMA (2019), UK (2019)
Median affinity: 5.43 pEC50
Reference (Journal): Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation.
Published in: Acta Physiol (Oxf)

Ligand: carvacrol (Natural product)
Interaction type: Activator
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels.
Published in: Nat Neurosci

Ligand: carveol (Natural product)
Interaction type: Activator
Action: Activation
Ligand approved: no
Median affinity: 2.52 pEC50
Reference (Journal): Monoterpenoid agonists of TRPV3.
Published in: Br J Pharmacol

Ligand: cinnamaldehyde (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  -
Reference (Journal): More than cool: promiscuous relationships of menthol and other sensory compounds.
Published in: Mol Cell Neurosci

Ligand: citral (Natural product)
Interaction type: Activator
Action: Activation
Ligand approved: no
Median affinity: 3.03 pKd
Reference (Journal): Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons.
Published in: PLoS ONE

Ligand: Citrusinine II (Natural product)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 4.909999847412109 pIC50
Reference (Journal): A plant-derived TRPV3 inhibitor suppresses pain and itch.
Published in: Br J Pharmacol

Ligand: compound 74a [PMID: 27077528] (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: yes
Median affinity: 6.420000076293945 pIC50
Reference (Journal): Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.
Published in: J Med Chem

Ligand: dihydrocarveol (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Median affinity: 2.59 pEC50
Reference (Journal): Monoterpenoid agonists of TRPV3.
Published in: Br J Pharmacol

Ligand: diphenylboronic anhydride (Synthetic organic)
Interaction type: Activator
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3.
Published in: J Biol Chem

Ligand: diphenyltetrahydrofuran (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3.
Published in: J Biol Chem

Ligand: eugenol (Natural product)
Interaction type: Activator
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 2.5 pEC50
Reference (Journal): Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels.
Published in: Nat Neurosci

Ligand: farnesyl diphosphate (Metabolite)
Interaction type: Activator
Action: Activation
Ligand approved: no
Median affinity: 6.89 pEC50
Reference (Journal): Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3.
Published in: J Biol Chem

Ligand: forsythoside B (Natural product)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.150000095367432 pIC50
Reference (Journal): Pharmacological Inhibition of the Temperature-Sensitive and Ca<sup>2+</sup>-Permeable Transient Receptor Potential Vanilloid TRPV3 Channel by Natural Forsythoside B Attenuates Pruritus and Cytotoxicity of Keratinocytes.
Published in: J Pharmacol Exp Ther

Ligand: incensole acetate (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 4.800000190734863 pEC50
Reference (Journal): Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain.
Published in: FASEB J

Ligand: Isochlorogenic acid A (Natural product)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.570000171661377 pIC50
Reference (Journal): Inhibition of temperature-sensitive TRPV3 channel by two natural isochlorogenic acid isomers for alleviation of dermatitis and chronic pruritus.
Published in: Acta Pharm Sin B

Ligand: Isochlorogenic acid B (Natural product)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.050000190734863 pIC50
Reference (Journal): Inhibition of temperature-sensitive TRPV3 channel by two natural isochlorogenic acid isomers for alleviation of dermatitis and chronic pruritus.
Published in: Acta Pharm Sin B

Ligand: isopentenyl diphosphate (Metabolite)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Median affinity: 6.62 pIC50
Reference (Journal): Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels.
Published in: Pain

Ligand: KS0365 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 5.289999961853027 pEC50
Reference (Journal): KS0365, a novel activator of the transient receptor potential vanilloid 3 (TRPV3) channel, accelerates keratinocyte migration.
Published in: Br J Pharmacol

Ligand: (-)-menthol (Natural product)
Interaction type: Activator
Action: Activation
Ligand approved: yes
Approval source: FDA (2008), no prior history available
Primary target: no
Median affinity: 1.7000000476837158 pEC50
Reference (Journal): More than cool: promiscuous relationships of menthol and other sensory compounds.
Published in: Mol Cell Neurosci

Ligand: osthole (Natural product)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 4.400000095367432 pIC50
Reference (Journal): Antipruritic Effect of Natural Coumarin Osthole through Selective Inhibition of Thermosensitive TRPV3 Channel in the Skin.
Published in: Mol Pharmacol

Ligand: ruthenium red (Inorganic)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6 pIC50
Reference (Journal): A heat-sensitive TRP channel expressed in keratinocytes.
Published in: Science

Ligand: tetrahydrocannabivarin (Natural product)
Interaction type: Activator
Action: Activation
Ligand approved: no
Median affinity: 5.42 pEC50
Reference (Journal): Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation.
Published in: Acta Physiol (Oxf)

Ligand: thymol (Natural product)
Interaction type: Activator
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 3.299999952316284 pEC50
Reference (Journal): Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels.
Published in: Nat Neurosci

Ligand: Trpvicin (Synthetic organic)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.420000076293945 pIC50
Reference (Journal): Structural basis of TRPV3 inhibition by an antagonist.
Published in: Nat Chem Biol

Ligand: vanillin (Natural product)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels.
Published in: Nat Neurosci

Ligand: verbascoside (Natural product)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 4.849999904632568 pIC50
Reference (Journal): Anti-pruritic and anti-inflammatory effects of natural verbascoside through selective inhibition of temperature-sensitive Ca<sup>2+</sup>-permeable TRPV3 channel.
Published in: J Dermatol Sci