Target family: Metabotropic glutamate receptors (type: gpcr)
Target: mGlu<sub>6</sub> receptor

Ligand: 1-benzyl-APDC (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 4.699999809265137 pEC50
Reference (Journal): Synthesis, molecular modeling, and biology of the 1-benzyl derivative of APDC-an apparent mGluR6 selective ligand.
Published in: Bioorg Med Chem Lett

Ligand: (1S,3R)-ACPD (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 4.2 pEC50
Reference (Journal): Synthesis, molecular modeling, and biology of the 1-benzyl derivative of APDC-an apparent mGluR6 selective ligand.
Published in: Bioorg Med Chem Lett

Ligand: (1S,3R)-ACPD (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 4.7 pEC50
Reference (Journal): Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor.
Published in: Neuropharmacology

Ligand: ACPT-I (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 4.7 pIC50

Ligand: α-methylserine-O-phosphate (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 4.1 pEC50
Reference (Journal): The metabotropic glutamate receptors: structure, activation mechanism and pharmacology.
Published in: Curr Drug Targets CNS Neurol Disord

Ligand: DCG-IV (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 5.6 pEC50
Reference (Journal): Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.
Published in: Neuropharmacology

Ligand: eglumegad (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.5 pIC50
Reference (Journal): Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors.
Published in: J Med Chem

Ligand: homo-AMPA (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.099999904632568 pEC50
Reference (Journal): A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid.
Published in: J Med Chem

Ligand: (R,S)-4-PPG (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.3 pEC50
Reference (Journal): (R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist is anticonvulsive and neuroprotective<i>in vivo</i>.
Published in: J Pharmacol Exp Ther

Ligand: (R,S)-4-PPG (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.3 pEC50
Reference (Journal): (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.
Published in: Neuropharmacology

Ligand: (S)-3,4-DCPG (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 5.400000095367432 pEC50
Reference (Journal): (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.
Published in: Neuropharmacology

Ligand: L-AP4 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor.
Published in: Neuropharmacology

Ligand: L-AP4 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.
Published in: Neuropharmacology

Ligand: L-CCG-I (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 6.199999809265137 pEC50
Reference (Journal): Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor.
Published in: Neuropharmacology

Ligand: L-CCG-I (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 5.199999809265137 pEC50
Reference (Journal): Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.
Published in: Neuropharmacology

Ligand: L-glutamic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 4.4 pEC50
Reference (Journal): Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.
Published in: Neuropharmacology

Ligand: L-glutamic acid (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.800000190734863 pEC50
Reference (Journal): New perspectives for the development of selective metabotropic glutamate receptor ligands.
Published in: Eur J Pharmacol

Ligand: L-glutamic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.2 pEC50
Reference (Journal): Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor.
Published in: Neuropharmacology

Ligand: L-serine-O-phosphate (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.4 pEC50
Reference (Journal): Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor.
Published in: Neuropharmacology

Ligand: LSP1-2111 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 5.77 pEC50
Reference (Journal): Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism.
Published in: FASEB J