Target family: Neuromedin U receptors (type: gpcr)
Target: NMU1 receptor

Ligand: neuromedin U-25 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.6 pKi
Reference (Journal): Radioligand binding and functional characterization of recombinant human NmU1 and NmU2 receptors stably expressed in clonal human embryonic kidney-293 cells.
Published in: Pharmacology

Ligand: compound 5d [PMID: 25815150] (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 10.079999923706055 pEC50
Reference (Journal): Discovery of potent hexapeptide agonists to human neuromedin u receptor 1 and identification of their serum metabolites.
Published in: ACS Med Chem Lett

Ligand: compound 8d [PMID: 24999562] (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Discovery of selective hexapeptide agonists to human neuromedin u receptors types 1 and 2.
Published in: J Med Chem

Ligand: CPN-223 (Peptide)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Primary target: no
Median affinity: 8.489999771118164 pEC50
Reference (Journal): Design and synthesis of peptidic partial agonists of human neuromedin U receptor 1 with enhanced serum stability.
Published in: Bioorg Med Chem Lett

Ligand: CPN-267 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: yes
Median affinity: 9.600000381469727 pEC50
Reference (Journal): Discovery of a Human Neuromedin U Receptor 1-Selective Hexapeptide Agonist with Enhanced Serum Stability.
Published in: J Med Chem

Ligand: HAS-NMU (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Development of a neuromedin U-human serum albumin conjugate as a long-acting candidate for the treatment of obesity and diabetes. Comparison with the PEGylated peptide.
Published in: J Pept Sci

Ligand: neuromedin S-33 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 10.199999809265137 pEC50
Reference (Journal): Identification of neuromedin S and its possible role in the mammalian circadian oscillator system.
Published in: EMBO J

Ligand: neuromedin S-33 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 10 pIC50
Reference (Journal): Identification of neuromedin S and its possible role in the mammalian circadian oscillator system.
Published in: EMBO J

Ligand: neuromedin U-23 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Radioligand binding and functional characterization of recombinant human NmU1 and NmU2 receptors stably expressed in clonal human embryonic kidney-293 cells.
Published in: Pharmacology

Ligand: neuromedin U-23 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 10.1 pKi
Reference (Journal): Radioligand binding and functional characterization of recombinant human NmU1 and NmU2 receptors stably expressed in clonal human embryonic kidney-293 cells.
Published in: Pharmacology

Ligand: neuromedin U-23 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Identification of receptors for neuromedin U and its role in feeding.
Published in: Nature

Ligand: neuromedin U-23 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system.
Published in: J Biol Chem

Ligand: neuromedin U-25 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system.
Published in: J Biol Chem

Ligand: neuromedin U-25 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system.
Published in: J Biol Chem

Ligand: neuromedin U-25 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Identification of receptors for neuromedin U and its role in feeding.
Published in: Nature

Ligand: neuromedin U-25 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.5 pKi
Reference (Journal): Radioligand binding and functional characterization of recombinant human NmU1 and NmU2 receptors stably expressed in clonal human embryonic kidney-293 cells.
Published in: Pharmacology

Ligand: neuromedin U-25 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Radioligand binding and functional characterization of recombinant human NmU1 and NmU2 receptors stably expressed in clonal human embryonic kidney-293 cells.
Published in: Pharmacology

Ligand: neuromedin U-25 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Radioligand binding and functional characterization of recombinant human NmU1 and NmU2 receptors stably expressed in clonal human embryonic kidney-293 cells.
Published in: Pharmacology