Target family: Cyclic nucleotide-regulated channels (CNG) (type: vgic)
Target: CNGA2

Ligand: all-trans-retinal (Metabolite)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity: 4.57 pIC50
Reference (Journal): All-trans-retinal shuts down rod cyclic nucleotide-gated ion channels: a novel role for photoreceptor retinoids in the response to bright light?
Published in: Proc Natl Acad Sci USA

Ligand: calmodulin (Peptide)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Calcium-calmodulin modulation of the olfactory cyclic nucleotide-gated cation channel.
Published in: Science

Ligand: calmodulin (Peptide)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Direct modulation by Ca(2+)-calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons.
Published in: Nature

Ligand: cyclic AMP (Metabolite)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP.
Published in: Proc Natl Acad Sci USA

Ligand: cyclic AMP (Metabolite)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Differential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels.
Published in: Sci Signal

Ligand: cyclic AMP (Metabolite)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): The native rat olfactory cyclic nucleotide-gated channel is composed of three distinct subunits.
Published in: J Neurosci

Ligand: cyclic AMP (Metabolite)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP.
Published in: Neuron

Ligand: cyclic GMP (Metabolite)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP.
Published in: Neuron

Ligand: cyclic GMP (Metabolite)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Differential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels.
Published in: Sci Signal

Ligand: cyclic GMP (Metabolite)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP.
Published in: Proc Natl Acad Sci USA

Ligand: dequalinium (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 5.599999904632568 pIC50
Reference (Journal): State-dependent block of CNG channels by dequalinium.
Published in: J Gen Physiol

Ligand: L-(cis)-diltiazem (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Median affinity: 2.12 pKi
Reference (Journal): Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons.
Published in: Nature

Ligand: PIP3 (Metabolite)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels.
Published in: Proc Natl Acad Sci USA

Ligand: pseudechetoxin (Peptide)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Median affinity: 8.3 pKi
Reference (Journal): Pseudechetoxin binds to the pore turret of cyclic nucleotide-gated ion channels.
Published in: J Gen Physiol

Ligand: pseudechetoxin (Peptide)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Median affinity: 8.3 pKi
Reference (Journal): Pseudechetoxin: a peptide blocker of cyclic nucleotide-gated ion channels.
Published in: Proc Natl Acad Sci USA