Target family: Succinate receptor (type: gpcr)
Target: succinate receptor

Ligand: compound 130 [PMID: 29157600] (Synthetic organic)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Primary target: no
Median affinity: 5.650000095367432 pEC50
Reference (Journal): Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91.
Published in: Mol Metab

Ligand: succinic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors.
Published in: Nature

Ligand: succinic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Screening β-Arrestin Recruitment for the Identification of Natural Ligands for Orphan G-Protein-Coupled Receptors.
Published in: J Biomol Screen

Ligand: (S)-chlorosuccinic acid (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 4.139999866485596 pEC50
Reference (Journal): Identification and pharmacological characterization of succinate receptor agonists.
Published in: Br J Pharmacol

Ligand: NF-56-EJ40 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.760000228881836 pKi
Reference (Journal): Structural basis of species-selective antagonist binding to the succinate receptor.
Published in: Nature

Ligand: NF-56-EJ40 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.480000019073486 pKd
Reference (Journal): Structural basis of species-selective antagonist binding to the succinate receptor.
Published in: Nature

Ligand: methylmalonic acid (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 3.549999952316284 pEC50
Reference (Journal): Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors.
Published in: Nature

Ligand: methylmalonic acid (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 3.7699999809265137 pEC50
Reference (Journal): Identification and pharmacological characterization of succinate receptor agonists.
Published in: Br J Pharmacol

Ligand: maleic acid (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Forskolin-free cAMP assay for Gi-coupled receptors.
Published in: Biochem Pharmacol

Ligand: maleic acid (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors.
Published in: Nature

Ligand: maleic acid (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Identification and pharmacological characterization of succinate receptor agonists.
Published in: Br J Pharmacol

Ligand: cis-epoxysuccinic acid (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 5.570000171661377 pEC50
Reference (Journal): Identification and pharmacological characterization of succinate receptor agonists.
Published in: Br J Pharmacol

Ligand: cis-epoxysuccinic acid (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 5.769999980926514 pEC50
Reference (Journal): Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91.
Published in: Mol Metab

Ligand: cis-1,2-cyclopropanedicarboxylic acid (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 4.309999942779541 pEC50
Reference (Journal): Identification and pharmacological characterization of succinate receptor agonists.
Published in: Br J Pharmacol

Ligand: compound 7e [PMID: 21571530] (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 6.74 pIC50
Reference (Journal): Discovery of a potent and selective small molecule hGPR91 antagonist.
Published in: Bioorg Med Chem Lett

Ligand: compound 5g [PMID: 21571530] (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 6.87 pIC50
Reference (Journal): Discovery of a potent and selective small molecule hGPR91 antagonist.
Published in: Bioorg Med Chem Lett

Ligand: compound 5g [PMID: 21571530] (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 7.46 pIC50
Reference (Journal): Discovery of a potent and selective small molecule hGPR91 antagonist.
Published in: Bioorg Med Chem Lett

Ligand: compound 31 [PMID: 29968758] (Synthetic organic)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Primary target: no
Median affinity: 7.639999866485596 pEC50
Reference (Journal): Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1.
Published in: Sci Rep