Target family: Transient Receptor Potential channels (TRP) (type: vgic)
Target: TRPC3

Ligand: 2-APB (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 5 pIC50
Reference (Journal): Mechanism of inhibition of TRPC cation channels by 2-aminoethoxydiphenylborane.
Published in: Mol Pharmacol

Ligand: ACAA (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -

Ligand: BTP2 (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 6.5 pIC50
Reference (Journal): A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2.
Published in: J Biol Chem

Ligand: clemizole (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 5.039999961853027 pIC50
Reference (Journal): Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5.
Published in: Mol Pharmacol

Ligand: Gd3+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7 pEC50
Reference (Journal): Inhibition of TRP3 channels by lanthanides. Block from the cytosolic side of the plasma membrane.
Published in: J Biol Chem

Ligand: GSK1702934A (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 7.099999904632568 pEC50
Reference (Journal): Characterization of Small Molecule TRPC3 and TRPC6 agonist and Antagonists
Published in: Biophys J

Ligand: GSK2833503A (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.679999828338623 pIC50
Reference (Journal): Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy.
Published in: Proc Natl Acad Sci USA

Ligand: GSK417651A (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.099999904632568 pIC50
Reference (Journal): The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore.
Published in: Bioorg Med Chem Lett

Ligand: KB-R7943 (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -

Ligand: La3+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 5.400000095367432 pIC50
Reference (Journal): Inhibition of TRP3 channels by lanthanides. Block from the cytosolic side of the plasma membrane.
Published in: J Biol Chem

Ligand: Ni2+ (Inorganic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -

Ligand: norgestimate (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: yes
Approval source: FDA (1989)
Primary target: no
Median affinity: 5.519999980926514 pKi
Reference (Journal): Inhibition of diacylglycerol-sensitive TRPC channels by synthetic and natural steroids.
Published in: PLoS ONE

Ligand: OAG (Metabolite)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.
Published in: Nature

Ligand: Pyr10 (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 6.139999866485596 pIC50
Reference (Journal): Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+)  entry pathways.
Published in: Br J Pharmacol

Ligand: Pyr3 (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.150000095367432 pIC50
Reference (Journal): Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound.
Published in: Proc Natl Acad Sci USA

Ligand: pyrazolopyrimidine 4n (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 7.71999979019165 pEC50
Reference (Journal): Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels.
Published in: J Med Chem

Ligand: SAR7334 (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.550000190734863 pIC50
Reference (Journal): Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels.
Published in: Br J Pharmacol

Ligand: SH045 (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.079999923706055 pIC50
Reference (Journal): A (+)-Larixol Congener with High Affinity and Subtype Selectivity toward TRPC6.
Published in: ChemMedChem

Ligand: SKF96365 (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -