Target family: Eta subfamily (type: enzyme)
Target: protein kinase C epsilon

Ligand: 10-Me-Aplog-1 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 8.699999809265137 pKi
Reference (Journal): Structure-activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity.
Published in: J Med Chem

Ligand: 7-hydroxystaurosporine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.28000020980835 pIC50
Reference (Journal): Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue.
Published in: Mol Pharmacol

Ligand: balanol (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.699999809265137 pIC50
Reference (Journal): Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A.
Published in: J Med Chem

Ligand: chelerythrine (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 7.619999885559082 pIC50
Reference (Journal): A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Published in: Proc Natl Acad Sci USA

Ligand: ingenol mebutate (Natural product)
Interaction type: Activator
Action: Activation
Ligand approved: yes
Approval source: FDA & EMA (2012)
Primary target: no
Median affinity: 9.770000457763672 pKi
Reference (Journal): Characterization of the interaction of ingenol 3-angelate with protein kinase C.
Published in: Cancer Res

Ligand: RasGRP activator 1 (Synthetic organic)
Interaction type: Activator
Action: Binding
Ligand approved: no
Primary target: no
Median affinity: 7.679999828338623 pKi
Reference (Journal): Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.
Published in: Bioorg Med Chem

Ligand: Ro-32-0432 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 6.96999979019165 pIC50
Reference (Journal): Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation.
Published in: J Pharmacol Exp Ther

Ligand: Ro-32-0432 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 6.96999979019165 pIC50
Reference (Journal): Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.
Published in: Biochem J

Ligand: sotrastaurin (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8.210000038146973 pIC50
Reference (Journal): Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.
Published in: J Med Chem

Ligand: Y27632 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.46999979019165 pIC50
Reference (Journal): Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account.
Published in: Bioorg Med Chem Lett