Target family: Transient Receptor Potential channels (TRP) (type: vgic)
Target: TRPML3

Ligand: estradiol 3-methyl ether (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 4.710000038146973 pIC50
Reference (Journal): Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors.
Published in: Sci Rep

Ligand: EVP-21 (Synthetic organic)
Interaction type: Activator
Action: None
Ligand approved: no
Primary target: no
Median affinity: 4.28000020980835 pEC50
Reference (Journal): Expanding the Toolbox: Novel Modulators of Endolysosomal Cation Channels.
Published in: Handb Exp Pharmacol

Ligand: Gd3+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 4.699999809265137 pIC50
Reference (Journal): The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration.
Published in: Proc Natl Acad Sci USA

Ligand: MK6-83 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Endolysosomal Cation Channels as Therapeutic Targets—Pharmacology of TRPML Channels
Published in: Messenger

Ligand: ML3-SA1 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 5.050000190734863 pEC50
Reference (Journal): Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice.
Published in: Nat Commun

Ligand: ML SA1 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release.
Published in: Nat Commun

Ligand: phosphatidyl (3,5) inositol bisphosphate (Metabolite)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome.
Published in: Nat Commun

Ligand: PRU-10 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 4.800000190734863 pIC50
Reference (Journal): Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors.
Published in: Sci Rep

Ligand: PRU-12 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 4.849999904632568 pIC50
Reference (Journal): Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors.
Published in: Sci Rep

Ligand: SF-11 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 6.590000152587891 pEC50
Reference (Journal): Small molecule activators of TRPML3.
Published in: Chem Biol

Ligand: SF-21 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Median affinity: 6.35 pEC50
Reference (Journal): Small molecule activators of TRPML3.
Published in: Chem Biol

Ligand: SN-1 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Median affinity: 6.06 pEC50
Reference (Journal): Small molecule activators of TRPML3.
Published in: Chem Biol

Ligand: SN-2 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Median affinity: 5.96 pEC50
Reference (Journal): Small molecule activators of TRPML3.
Published in: Chem Biol