Target family: Neuromedin U receptors (type: gpcr)
Target: NMU1 receptor

Ligand: [125I]neuromedin U-8 (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.6 pKd
Reference (Journal): Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system.
Published in: J Biol Chem

Ligand: [125I]neuromedin U-25 (human) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKd
Reference (Journal): Signaling and ligand binding by recombinant neuromedin U receptors: evidence for dual coupling to Galphaq/11 and Galphai and an irreversible ligand-receptor interaction.
Published in: Mol Pharmacol

Ligand: [125I]neuromedin U-25 (human) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKd
Reference (Journal): Radioligand binding and functional characterization of recombinant human NmU1 and NmU2 receptors stably expressed in clonal human embryonic kidney-293 cells.
Published in: Pharmacology

Ligand: [125I]neuromedin U-23 (rat) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKd
Reference (Journal): Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system.
Published in: J Biol Chem

Ligand: [125I]neuromedin U-23 (rat) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKd
Reference (Journal): Identification of receptors for neuromedin U and its role in feeding.
Published in: Nature

Ligand: PEG40-NMU (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): PEGylation of Neuromedin U yields a promising candidate for the treatment of obesity and diabetes.
Published in: Bioorg Med Chem

Ligand: NM4-C16 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 6.300000190734863 pEC50
Reference (Journal): Small lipidated anti-obesity compounds derived from neuromedin U.
Published in: Eur J Med Chem

Ligand: neuromedin U-8 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system.
Published in: J Biol Chem

Ligand: neuromedin U-8 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Radioligand binding and functional characterization of recombinant human NmU1 and NmU2 receptors stably expressed in clonal human embryonic kidney-293 cells.
Published in: Pharmacology

Ligand: neuromedin U-8 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.5 pKi
Reference (Journal): Radioligand binding and functional characterization of recombinant human NmU1 and NmU2 receptors stably expressed in clonal human embryonic kidney-293 cells.
Published in: Pharmacology

Ligand: neuromedin U-8 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.8 pKi
Reference (Journal): Radioligand binding and functional characterization of recombinant human NmU1 and NmU2 receptors stably expressed in clonal human embryonic kidney-293 cells.
Published in: Pharmacology

Ligand: neuromedin U-8 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Identification of receptors for neuromedin U and its role in feeding.
Published in: Nature

Ligand: neuromedin U-25 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Identification of receptors for neuromedin U and its role in feeding.
Published in: Nature

Ligand: neuromedin U-25 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Signaling and ligand binding by recombinant neuromedin U receptors: evidence for dual coupling to Galphaq/11 and Galphai and an irreversible ligand-receptor interaction.
Published in: Mol Pharmacol