Target family: SLC29 family (type: transporter)
Target: Plasma membrane monoamine transporter

Ligand: verapamil (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1981)
Primary target: no
Median affinity: 4.730000019073486 pKi
Reference (Journal): The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Published in: Clin Pharmacol Ther

Ligand: verapamil (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1981)
Primary target: no
Median affinity: 4.730000019073486 pKi
Reference (Journal): Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Published in: Mol Pharmacol

Ligand: rhodamine123 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.989999771118164 pKi
Reference (Journal): The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Published in: Clin Pharmacol Ther

Ligand: rhodamine123 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.989999771118164 pKi
Reference (Journal): Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Published in: Mol Pharmacol

Ligand: quinine (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (2005, as quinine sulfate, previous history unspecified)
Primary target: no
Median affinity: 4.570000171661377 pKi
Reference (Journal): Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Published in: Mol Pharmacol

Ligand: quinine (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (2005, as quinine sulfate, previous history unspecified)
Primary target: no
Median affinity: 4.570000171661377 pKi
Reference (Journal): The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Published in: Clin Pharmacol Ther

Ligand: quinidine (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1950)
Primary target: no
Median affinity: 4.599999904632568 pKi
Reference (Journal): The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Published in: Clin Pharmacol Ther

Ligand: quinidine (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1950)
Primary target: no
Median affinity: 4.599999904632568 pKi
Reference (Journal): Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Published in: Mol Pharmacol

Ligand: fluoxetine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1987)
Primary target: no
Median affinity: 4.639999866485596 pKi
Reference (Journal): Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Published in: Mol Pharmacol

Ligand: fluoxetine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1987)
Primary target: no
Median affinity: 4.639999866485596 pKi
Reference (Journal): The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Published in: Clin Pharmacol Ther

Ligand: dipyridamole (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1961)
Primary target: no
Median affinity: 5.900000095367432 pKi
Reference (Journal): Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4).
Published in: Biochem Pharmacol

Ligand: desipramine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (no history prior to 1964)
Primary target: no
Median affinity: 4.489999771118164 pKi
Reference (Journal): Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Published in: Mol Pharmacol

Ligand: desipramine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (no history prior to 1964)
Primary target: no
Median affinity: 4.489999771118164 pKi
Reference (Journal): The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Published in: Clin Pharmacol Ther

Ligand: decynium 22 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7 pKi
Reference (Journal): The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Published in: Clin Pharmacol Ther

Ligand: decynium 22 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7 pKi
Reference (Journal): Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Published in: Mol Pharmacol

Ligand: cimetidine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1977)
Primary target: no
Median affinity: 3.299999952316284 pKi
Reference (Journal): Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Published in: Mol Pharmacol

Ligand: cimetidine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1977)
Primary target: no
Median affinity: 3.299999952316284 pKi
Reference (Journal): The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Published in: Clin Pharmacol Ther