Target family: P2Y receptors (type: gpcr)
Target: P2Y<sub>6</sub> receptor

Ligand: UTP (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 5.2 pEC50
Reference (Journal): Cloning, functional expression and tissue distribution of the human P2Y6 receptor.
Published in: Biochem Biophys Res Commun

Ligand: Up3U (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.7 pEC50
Reference (Journal): P2 receptors activated by uracil nucleotides--an update.
Published in: Curr Med Chem

Ligand: UDP-β-S (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.55 pEC50
Reference (Journal): P2 receptors activated by uracil nucleotides--an update.
Published in: Curr Med Chem

Ligand: UDP (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 6.5 pEC50
Reference (Journal): Cloning, functional expression and tissue distribution of the human P2Y6 receptor.
Published in: Biochem Biophys Res Commun

Ligand: TIM-38 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 5.369999885559082 pIC50
Reference (Journal): Identification of novel selective P2Y<sub>6</sub> receptor antagonists by high-throughput screening assay.
Published in: Life Sci

Ligand: suramin (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: yes
Primary target: no
Median affinity: 4 pKB
Reference (Journal): Pharmacology and structure of P2Y receptors.
Published in: Neuropharmacology

Ligand: Rp-5-OMe-UDPαB (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 8.100000381469727 pEC50
Reference (Journal): 5-OMe-uridine-5'-O-(α-boranodiphosphate), a novel nucleotide derivative highly active at the human P2Y(6) receptor protects against death-receptor mediated glial apoptosis.
Published in: Neurosci Lett

Ligand: Rp-5-OMe-UDPαB (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 8.100000381469727 pEC50
Reference (Journal): UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety.
Published in: Bioorg Med Chem

Ligand: reactive blue-2 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 4.5 pIC50
Reference (Journal): P2 receptors activated by uracil nucleotides--an update.
Published in: Curr Med Chem

Ligand: reactive blue-2 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 6 pKB
Reference (Journal): Pharmacology and structure of P2Y receptors.
Published in: Neuropharmacology

Ligand: PPADS (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 4 pKB
Reference (Journal): Pharmacology and structure of P2Y receptors.
Published in: Neuropharmacology

Ligand: MRS4162-BODIPY conjugate (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 7.639999866485596 pEC50
Reference (Journal): 4-Alkyloxyimino derivatives of uridine-5'-triphosphate: distal modification of potent agonists as a strategy for molecular probes of P2Y2, P2Y4, and P2Y6 receptors.
Published in: J Med Chem

Ligand: MRS2957 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 7.900000095367432 pEC50
Reference (Journal): Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications.
Published in: J Med Chem

Ligand: MRS2782 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.18 pEC50
Reference (Journal): Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.
Published in: Bioorg Med Chem