Target family: GPR18, GPR55 and GPR119 (type: gpcr)
Target: <i>GPR18</i>

Ligand: abnormal cannabidiol (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.08 pEC50
Reference (Journal): Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.
Published in: Br J Pharmacol

Ligand: AM251 (Synthetic organic)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 4.02 pEC50
Reference (Journal): Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.
Published in: Br J Pharmacol

Ligand: anandamide (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.42 pEC50
Reference (Journal): Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.
Published in: Br J Pharmacol

Ligand: arachidonylcyclopropylamide (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 4.87 pEC50
Reference (Journal): Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.
Published in: Br J Pharmacol

Ligand: cannabidiol (Natural product)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: yes
Approval source: FDA (2018), EMA (2019), UK (2019)
Median affinity: 4.29 pEC50
Reference (Journal): Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.
Published in: Br J Pharmacol

Ligand: Δ9-tetrahydrocannabinol (Natural product)
Interaction type: Agonist
Action: Full agonist
Ligand approved: yes
Approval source: FDA (1985)
Primary target: no
Median affinity: 6.019999980926514 pEC50
Reference (Journal): Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.
Published in: Br J Pharmacol

Ligand: Δ9-tetrahydrocannabinol (Natural product)
Interaction type: Agonist
Action: Full agonist
Ligand approved: yes
Approval source: FDA (1985)
Primary target: no
Median affinity: 6.019999980926514 pEC50
Reference (Journal): So what do we call GPR18 now?
Published in: Br J Pharmacol

Ligand: N-arachidonoylglycine (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.
Published in: Br J Pharmacol

Ligand: N-arachidonoylglycine (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.
Published in: Biochem Biophys Res Commun

Ligand: O-1602 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.19 pEC50
Reference (Journal): Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.
Published in: Br J Pharmacol

Ligand: PSB-KD107 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 6.25 pEC50
Reference (Journal): Discovery of Tricyclic Xanthines as Agonists of the Cannabinoid-Activated Orphan G-Protein-Coupled Receptor GPR18
Published in: ACS Medicinal Chemistry Letters

Ligand: PSB-KK1415 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 7.71999979019165 pEC50
Reference (Journal): Potent, Selective Agonists for the Cannabinoid-like Orphan G&#xa0;Protein-Coupled Receptor GPR18: A Promising Drug Target for&#xa0;Cancer and Immunity.
Published in: J Med Chem

Ligand: PSB-KK1445 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 7.340000152587891 pEC50
Reference (Journal): Potent, Selective Agonists for the Cannabinoid-like Orphan G&#xa0;Protein-Coupled Receptor GPR18: A Promising Drug Target for&#xa0;Cancer and Immunity.
Published in: J Med Chem