Target family: Glycine receptors (type: lgic)
Target: Glycine Receptor (All subtypes)

Ligand: picrotoxinin (Natural product)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore.
Published in: J Neurochem

Ligand: picrotoxinin (Natural product)
Interaction type: Subunit-specific
Action: Inhibition
Ligand approved: no
Median affinity:  -
Reference (Journal): A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore.
Published in: J Neurochem

Ligand: pregnenolone (Metabolite)
Interaction type: Subunit-specific
Action: Potentiation
Ligand approved: yes
Median affinity:  -
Reference (Journal): Subunit-specific modulation of glycine receptors by neurosteroids.
Published in: Neuropharmacology

Ligand: progesterone (Metabolite)
Interaction type: Subunit-specific
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1959)
Median affinity:  -
Reference (Journal): Subunit-specific modulation of glycine receptors by neurosteroids.
Published in: Neuropharmacology

Ligand: RU5135 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.5 pKd
Reference (Journal): Antagonism of inhibitory amino acids by the steroid derivative RU5135.
Published in: Br J Pharmacol

Ligand: RU5135 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.5 pKd
Reference (Journal): Glycine antagonism by RU 5135.
Published in: Eur J Pharmacol

Ligand: [3H]strychnine (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.5 pKd
Reference (Journal): Distinct agonist- and antagonist-binding sites on the glycine receptor.
Published in: Neuron

Ligand: [3H]strychnine (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.5 pKd
Reference (Journal): Distinct agonist- and antagonist-binding sites on the glycine receptor.
Published in: Neuron

Ligand: [3H]strychnine (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.5 pKd
Reference (Journal): The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors.
Published in: Nature

Ligand: taurine (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 3.84 pEC50
Reference (Journal): Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel.
Published in: EMBO J

Ligand: tropisetron (Synthetic organic)
Interaction type: Subunit-specific
Action: Potentiation
Ligand approved: yes
Median affinity:  -
Reference (Journal): Glycine receptor beta subunits play a critical role in potentiation of glycine responses by ICS-205,930.
Published in: Mol Pharmacol

Ligand: tropisetron (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: yes
Median affinity: 4.1 pIC50
Reference (Journal): Selective blocking effects of tropisetron and atropine on recombinant glycine receptors.
Published in: J Neurochem

Ligand: tropisetron (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: yes
Median affinity: 4.1 pIC50
Reference (Journal): Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition.
Published in: J Neurochem

Ligand: WIN55212-2 (Synthetic organic)
Interaction type: Subunit-specific
Action: Inhibition
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine.
Published in: Biochem Pharmacol

Ligand: Zn2+ (Inorganic)
Interaction type: Subunit-specific
Action: Inhibition
Ligand approved: no
Median affinity:  -
Reference (Journal): Molecular determinants of glycine receptor alphabeta subunit sensitivities to Zn2+-mediated inhibition.
Published in: J Physiol (Lond.)

Ligand: Zn2+ (Inorganic)
Interaction type: Allosteric modulator
Action: Potentiation
Ligand approved: no
Median affinity:  -
Reference (Journal): Biphasic modulation of the strychnine-sensitive glycine receptor by Zn2+.
Published in: Mol Pharmacol

Ligand: Zn2+ (Inorganic)
Interaction type: Subunit-specific
Action: Potentiation
Ligand approved: no
Median affinity:  -
Reference (Journal): Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors.
Published in: J Biol Chem

Ligand: Zn2+ (Inorganic)
Interaction type: Allosteric modulator
Action: Inhibition
Ligand approved: no
Median affinity:  -
Reference (Journal): Zinc potentiation of the glycine receptor chloride channel is mediated by allosteric pathways.
Published in: J Neurochem

Ligand: Zn2+ (Inorganic)
Interaction type: Allosteric modulator
Action: Inhibition
Ligand approved: no
Median affinity:  -
Reference (Journal): Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors.
Published in: J Biol Chem

Ligand: Zn2+ (Inorganic)
Interaction type: Allosteric modulator
Action: Potentiation
Ligand approved: no
Median affinity:  -
Reference (Journal): Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors.
Published in: J Biol Chem

Ligand: Zn2+ (Inorganic)
Interaction type: Allosteric modulator
Action: Potentiation
Ligand approved: no
Median affinity:  -
Reference (Journal): Zinc potentiation of the glycine receptor chloride channel is mediated by allosteric pathways.
Published in: J Neurochem

Ligand: Zn2+ (Inorganic)
Interaction type: Allosteric modulator
Action: Inhibition
Ligand approved: no
Median affinity:  -
Reference (Journal): Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors.
Published in: J Physiol (Lond.)

Ligand: Zn2+ (Inorganic)
Interaction type: Allosteric modulator
Action: Potentiation
Ligand approved: no
Median affinity:  -
Reference (Journal): Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors.
Published in: J Physiol (Lond.)