Target family: Calcitonin receptors (type: gpcr)
Target: AMY<sub>1</sub> receptor

Ligand: AC187 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 8.020000457763672 pKB
Reference (Journal): Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.
Published in: Mol Pharmacol

Ligand: adrenomedullin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins.
Published in: Biochem Biophys Res Commun

Ligand: adrenomedullin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.
Published in: Mol Pharmacol

Ligand: adrenomedullin 2/intermedin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8 pEC50
Reference (Journal): The pharmacology of adrenomedullin 2/intermedin.
Published in: Br J Pharmacol

Ligand: α-CGRP (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins.
Published in: Biochem Biophys Res Commun

Ligand: α-CGRP (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): A second trigeminal CGRP receptor: function and expression of the AMY1 receptor.
Published in: Ann Clin Transl Neurol

Ligand: α-CGRP (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Receptor-activity-modifying protein 1 forms heterodimers with two G-protein-coupled receptors to define ligand recognition.
Published in: Biochem J

Ligand: α-CGRP (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.
Published in: Mol Pharmacol

Ligand: α-CGRP (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins.
Published in: Mol Pharmacol

Ligand: α-CGRP-(8-37) (human) (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 6.62 pKB
Reference (Journal): Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.
Published in: Mol Pharmacol

Ligand: amylin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.
Published in: Mol Pharmacol

Ligand: amylin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Pharmacological characterization of receptor-activity-modifying proteins (RAMPs) and the human calcitonin receptor.
Published in: J Pharmacol Toxicol Methods

Ligand: amylin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins.
Published in: Mol Pharmacol