Target family: Inwardly rectifying potassium channels (K<sub>IR</sub>) (type: vgic)
Target: K<sub>ir</sub>2.1

Ligand: Ba2+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pKd
Reference (Journal): Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues.
Published in: J Physiol (Lond.)

Ligand: Cs+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pKd
Reference (Journal): The role of a single aspartate residue in ionic selectivity and block of a murine inward rectifier K+ channel Kir2.1.
Published in: J Physiol (Lond.)

Ligand: Mg2+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 4.800000190734863 pKd
Reference (Journal): Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel.
Published in: Neuron

Ligand: oleoyl-CoA (Metabolite)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels.
Published in: J Biol Chem

Ligand: oleoyl-CoA (Metabolite)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Cytoplasmic accumulation of long-chain coenzyme A esters activates KATP and inhibits Kir2.1 channels.
Published in: J Physiol (Lond.)

Ligand: PIP2 (Metabolite)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma.
Published in: Nature

Ligand: PIP2 (Metabolite)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels.
Published in: J Biol Chem

Ligand: PIP2 (Metabolite)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium channels.
Published in: FEBS Lett

Ligand: putrescine (Metabolite)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 5.099999904632568 pKd
Reference (Journal): Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel.
Published in: Neuron

Ligand: putrescine (Metabolite)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 5.099999904632568 pKd
Reference (Journal): The tetravalent organic cation spermine causes the gating of the IRK1 channel expressed in murine fibroblast cells.
Published in: J Physiol (Lond.)

Ligand: Rb+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Median affinity:  -
Reference (Journal): The role of a single aspartate residue in ionic selectivity and block of a murine inward rectifier K+ channel Kir2.1.
Published in: J Physiol (Lond.)

Ligand: spermidine (Metabolite)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 8.100000381469727 pKd
Reference (Journal): Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel.
Published in: Neuron