Target family: <i>N</i>-Acylethanolamine turnover (type: enzyme)
Target: Fatty acid amide hydrolase

Ligand: PF3845 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.6 pIC50
Reference (Journal): Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
Published in: Chem Biol

Ligand: PF-04457845 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.
Published in: Science

Ligand: PF-04457845 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.
Published in: ACS Med Chem Lett

Ligand: OL135 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.4 pIC50
Reference (Journal): A second fatty acid amide hydrolase with variable distribution among placental mammals.
Published in: J Biol Chem

Ligand: MM-433593 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7 pIC50

Ligand: JZL195 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.699999809265137 pIC50
Reference (Journal): Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.
Published in: Proc Natl Acad Sci USA

Ligand: JNJ-42165279 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.489999771118164 pIC50
Reference (Patent): Modulators of fatty acid amide hydrolase.

Ligand: JNJ-42165279 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 7.119999885559082 pIC50
Reference (Patent): Modulators of fatty acid amide hydrolase.

Ligand: JNJ40355003 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8.850000381469727 pIC50
Reference (Journal): Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate.
Published in: ACS Med Chem Lett

Ligand: ASP8477 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.399999618530273 pIC50
Reference (Journal): In vitro and in vivo pharmacological characterization of ASP8477: A novel highly selective fatty acid amide hydrolase inhibitor.
Published in: Eur J Pharmacol

Ligand: BIA 10-2474 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.
Published in: Science

Ligand: BIA 10-2474 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.699999809265137 pIC50
Reference (Patent): Pharmaceutical compounds.

Ligand: BIA 10-2639 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.
Published in: Science

Ligand: CAY10499 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.849999904632568 pIC50
Reference (Journal): 4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors.
Published in: J Enzyme Inhib Med Chem

Ligand: compound 19y [Kiss et al., 2011] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.220000267028809 pIC50
Reference (Journal): Design, synthesis, and structure–activity relationships of 1,3,4-oxadiazol-2(3H)-ones as novel FAAH inhibitors.
Published in: Medchemcomm