Target family: Neurotensin receptors (type: gpcr)
Target: NTS<sub>1</sub> receptor

Ligand: JMV458 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.8 pKi
Reference (Journal): Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2.
Published in: Mol Pharmacol

Ligand: ABS-201 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 8 pIC50
Reference (Journal): Pharmacological hypothermia induced neurovascular protection after severe stroke of transient middle cerebral artery occlusion in mice.
Published in: Exp Neurol

Ligand: ABS-201 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 8 pIC50
Reference (Journal): A novel stroke therapy of pharmacologically induced hypothermia after focal cerebral ischemia in mice.
Published in: FASEB J

Ligand: ABS-212 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 7.639999866485596 pIC50
Reference (Journal): Identification and functional characterization of a stable, centrally active derivative of the neurotensin (8-13) fragment as a potential first-in-class analgesic.
Published in: J Med Chem

Ligand: ABS-212 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 7.639999866485596 pIC50
Reference (Journal): The Effects of Pharmacological Hypothermia Induced by Neurotensin Receptor Agonist ABS 201 on Outcomes of CPR.
Published in: Shock

Ligand: contulakin-G (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.3 pIC50
Reference (Journal): Contulakin-G, an O-glycosylated invertebrate neurotensin.
Published in: J Biol Chem

Ligand: contulakin-G (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6 pIC50
Reference (Journal): Contulakin-G, an O-glycosylated invertebrate neurotensin.
Published in: J Biol Chem

Ligand: EISAI-1 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.5 pKi
Reference (Journal): Differential involvement of intracellular domains of the rat NTS1 neurotensin receptor in coupling to G proteins: a molecular basis for agonist-directed trafficking of receptor stimulus.
Published in: Mol Pharmacol

Ligand: EISAI-2 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.8 pKi
Reference (Journal): Differential involvement of intracellular domains of the rat NTS1 neurotensin receptor in coupling to G proteins: a molecular basis for agonist-directed trafficking of receptor stimulus.
Published in: Mol Pharmacol

Ligand: JMV2004 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.7 pKi
Reference (Journal): Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2.
Published in: Mol Pharmacol

Ligand: JMV431 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.3 pKi
Reference (Journal): Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2.
Published in: Mol Pharmacol

Ligand: JMV449 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 10 pKi
Reference (Journal): Differential involvement of intracellular domains of the rat NTS1 neurotensin receptor in coupling to G proteins: a molecular basis for agonist-directed trafficking of receptor stimulus.
Published in: Mol Pharmacol

Ligand: JMV457 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.8 pKi
Reference (Journal): Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2.
Published in: Mol Pharmacol