Target family: Two-pore domain potassium channels  (K<sub>2P</sub>) (type: vgic)
Target: K<sub>2P</sub>3.1

Ligand: isoflurane (Synthetic organic)
Interaction type: Activator
Action: Positive
Ligand approved: yes
Approval source: FDA (1979)
Median affinity: 2.7 pEC50
Reference (Journal): Serotonergic raphe neurons express TASK channel transcripts and a TASK-like pH- and halothane-sensitive K+ conductance.
Published in: J Neurosci

Ligand: R-(+)-methanandamide (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.150000095367432 pIC50
Reference (Journal): The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1.
Published in: EMBO J

Ligand: halothane (Synthetic organic)
Interaction type: Activator
Action: None
Ligand approved: yes
Approval source: FDA (1958)
Primary target: no
Median affinity:  -
Reference (Journal): Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anesthetics.
Published in: J Neurosci

Ligand: halothane (Synthetic organic)
Interaction type: Activator
Action: Positive
Ligand approved: yes
Approval source: FDA (1958)
Primary target: no
Median affinity: 3 pEC50
Reference (Journal): Serotonergic raphe neurons express TASK channel transcripts and a TASK-like pH- and halothane-sensitive K+ conductance.
Published in: J Neurosci

Ligand: halothane (Synthetic organic)
Interaction type: Activator
Action: Positive
Ligand approved: yes
Approval source: FDA (1958)
Primary target: no
Median affinity: 3 pEC50
Reference (Journal): A mammalian two pore domain mechano-gated S-like K+ channel.
Published in: EMBO J

Ligand: Ba2+ (Inorganic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Median affinity: 0.3 pIC50

Ligand: AVE1231 (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.699999809265137 pIC50
Reference (Journal): Identification of the A293 (AVE1231) Binding Site in the Cardiac Two-Pore-Domain Potassium Channel TASK-1: a Common Low Affinity Antiarrhythmic Drug Binding Site.
Published in: Cell Physiol Biochem

Ligand: arachidonic acid (Metabolite)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Median affinity: 1 pIC50
Reference (Journal): The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1.
Published in: EMBO J

Ligand: angiotensin II (Peptide)
Interaction type: Channel blocker
Action: None
Ligand approved: yes
Approval source: FDA (2017)
Median affinity:  -
Reference (Journal): TASK (TWIK-related acid-sensitive K+ channel) is expressed in glomerulosa cells of rat adrenal cortex and inhibited by angiotensin II.
Published in: Mol Endocrinol

Ligand: anandamide (Metabolite)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.599999904632568 pIC50
Reference (Journal): The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1.
Published in: EMBO J

Ligand: anandamide (Metabolite)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.150000095367432 pIC50
Reference (Journal): The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1.
Published in: EMBO J