Target family: Taste 2 receptors (type: gpcr)
Target: <i>TAS2R43</i>

Ligand: saccharin (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 2.7699999809265137 pEC50
Reference (Journal): Bitter taste receptors for saccharin and acesulfame K.
Published in: J Neurosci

Ligand: lactucopicrin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 6.340000152587891 pEC50
Reference (Journal): Overlapping activation pattern of bitter taste receptors affect sensory adaptation and food perception.
Published in: Front Nutr

Ligand: grosheimin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.159999847412109 pEC50
Reference (Journal): Receptor Polymorphism and Genomic Structure Interact to Shape Bitter Taste Perception.
Published in: PLoS Genet

Ligand: GIV3727 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 4.949999809265137 pIC50
Reference (Journal): Modulation of bitter taste perception by a small molecule hTAS2R antagonist.
Published in: Curr Biol

Ligand: Cyclolinopeptide 1-Mso,3-Met-CL6 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.53000020980835 pEC50
Reference (Journal): Activation Spectra of Human Bitter Taste Receptors Stimulated with Cyclolinopeptides Corresponding to Fresh and Aged Linseed Oil.
Published in: J Agric Food Chem

Ligand: cyclamate (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 2.319999933242798 pIC50
Reference (Journal): Blends of Non-caloric Sweeteners Saccharin and Cyclamate Show Reduced Off-Taste due to TAS2R Bitter Receptor Inhibition.
Published in: Cell Chem Biol

Ligand: citronellal (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 4.079999923706055 pIC50
Reference (Journal): The Odorant ( R)-Citronellal Attenuates Caffeine Bitterness by Inhibiting the Bitter Receptors TAS2R43 and TAS2R46.
Published in: J Agric Food Chem

Ligand: bengalensol (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.409999847412109 pEC50
Reference (Journal): Numerous Compounds Orchestrate Coffee's Bitterness.
Published in: J Agric Food Chem

Ligand: aristolochic acid (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 7.099999904632568 pEC50
Reference (Journal): Bitter taste receptors for saccharin and acesulfame K.
Published in: J Neurosci

Ligand: amarogentin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.119999885559082 pEC50
Reference (Journal): The molecular receptive ranges of human TAS2R bitter taste receptors.
Published in: Chem Senses

Ligand: aloin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.920000076293945 pEC50
Reference (Journal): Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin.
Published in: Curr Biol

Ligand: acesulfame (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 2.509999990463257 pEC50
Reference (Journal): Bitter taste receptors for saccharin and acesulfame K.
Published in: J Neurosci

Ligand: 3-methylhexanal (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 4.130000114440918 pIC50
Reference (Journal): The Odorant ( R)-Citronellal Attenuates Caffeine Bitterness by Inhibiting the Bitter Receptors TAS2R43 and TAS2R46.
Published in: J Agric Food Chem