Target family: Delta subfamily (type: enzyme)
Target: protein kinase C delta

Ligand: 10-Me-Aplog-1 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 9.34000015258789 pKi
Reference (Journal): Structure-activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity.
Published in: J Med Chem

Ligand: 7-hydroxystaurosporine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.230000019073486 pIC50
Reference (Journal): Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue.
Published in: Mol Pharmacol

Ligand: balanol (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.800000190734863 pIC50
Reference (Journal): Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A.
Published in: J Med Chem

Ligand: CC-90005 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.349999904632568 pIC50
Reference (Journal): Discovery of the Selective Protein Kinase C-&#x3b8; Kinase Inhibitor, CC-90005.
Published in: J Med Chem

Ligand: compound 23 [PMID: 35816678] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.150000095367432 pIC50
Reference (Journal): Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease.
Published in: J Med Chem

Ligand: enzastaurin (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6 pIC50
Reference (Journal): Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta.
Published in: Bioorg Med Chem Lett

Ligand: Gö 6983 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8 pIC50
Reference (Journal): Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes.
Published in: FEBS Lett

Ligand: ingenol mebutate (Natural product)
Interaction type: Activator
Action: Activation
Ligand approved: yes
Approval source: FDA & EMA (2012)
Primary target: yes
Median affinity: 9.420000076293945 pKi
Reference (Journal): Characterization of the interaction of ingenol 3-angelate with protein kinase C.
Published in: Cancer Res

Ligand: rottlerin (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.519999980926514 pIC50
Reference (Journal): Rottlerin, a novel protein kinase inhibitor.
Published in: Biochem Biophys Res Commun

Ligand: ruboxistaurin (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.599999904632568 pIC50
Reference (Journal): (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.
Published in: J Med Chem

Ligand: sotrastaurin (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8.890000343322754 pIC50
Reference (Journal): Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.
Published in: J Med Chem