Target family: Free fatty acid receptors (type: gpcr)
Target: FFA3 receptor

Ligand: 1-methylcyclopropanecarboxylic acid (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 3.9000000953674316 pEC50
Reference (Journal): Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.
Published in: J Biol Chem

Ligand: acetic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.
Published in: J Biol Chem

Ligand: acetic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.
Published in: J Biol Chem

Ligand: acetic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.
Published in: Proc Natl Acad Sci USA

Ligand: acetic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.
Published in: J Biol Chem

Ligand: butyric acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.
Published in: J Biol Chem

Ligand: butyric acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.
Published in: J Biol Chem

Ligand: butyric acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.
Published in: Proc Natl Acad Sci USA

Ligand: butyric acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.
Published in: J Biol Chem

Ligand: FHQC (Synthetic organic)
Interaction type: Allosteric modulator
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.650000095367432 pEC50
Reference (Journal): Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands.
Published in: Mol Pharmacol

Ligand: isobutyric acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.
Published in: J Biol Chem

Ligand: isobutyric acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.
Published in: Proc Natl Acad Sci USA

Ligand: pentanoic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.
Published in: Proc Natl Acad Sci USA

Ligand: pentanoic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.
Published in: J Biol Chem

Ligand: propanoic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.
Published in: J Biol Chem

Ligand: propanoic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.
Published in: J Biol Chem

Ligand: propanoic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.
Published in: J Biol Chem

Ligand: propanoic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.
Published in: Proc Natl Acad Sci USA

Ligand: (S)-4-CMTB (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.4 pKi
Reference (Journal): Identification and functional characterization of allosteric agonists for the G protein-coupled receptor FFA2.
Published in: Mol Pharmacol