Target family: Inwardly rectifying potassium channels (K<sub>IR</sub>) (type: vgic)
Target: K<sub>ir</sub>6.1

Ligand: UDP (Metabolite)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
Published in: J Physiol (Lond.)

Ligand: tolbutamide (Synthetic organic)
Interaction type: Inhibitor
Action: None
Ligand approved: yes
Approval source: FDA (1979)
Primary target: no
Median affinity:  -

Ligand: pinacidil (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: yes
Approval source: FDA (1989)
Median affinity:  -
Reference (Journal): Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
Published in: J Physiol (Lond.)

Ligand: nicorandil (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: yes
Approval source: UK (2009)
Primary target: no
Median affinity:  -
Reference (Journal): Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
Published in: J Physiol (Lond.)

Ligand: minoxidil (Synthetic organic)
Interaction type: Activator
Action: None
Ligand approved: yes
Approval source: FDA (1979)
Primary target: no
Median affinity:  -

Ligand: guanosine-5'-triphosphate (Metabolite)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
Published in: J Physiol (Lond.)

Ligand: guanosine-5'-triphosphate (Metabolite)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
Published in: J Physiol (Lond.)

Ligand: guanosine 5'-diphosphate (Metabolite)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
Published in: J Physiol (Lond.)

Ligand: glibenclamide (Synthetic organic)
Interaction type: Inhibitor
Action: None
Ligand approved: yes
Approval source: FDA (as glyburide, 1984), EMA (2018)
Primary target: no
Median affinity:  -

Ligand: diazoxide (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: yes
Approval source: FDA (1973)
Primary target: no
Median affinity:  -
Reference (Journal): Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
Published in: J Physiol (Lond.)

Ligand: cromakalim (Synthetic organic)
Interaction type: Activator
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -

Ligand: ATP (Metabolite)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
Published in: J Physiol (Lond.)

Ligand: ATP (Metabolite)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
Published in: J Physiol (Lond.)