Target family: Class A Orphans (type: gpcr)
Target: <i>LGR6</i>

Ligand: R-spondin-4 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
Published in: Proc Natl Acad Sci USA

Ligand: R-spondin-4 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.15 pIC50
Reference (Journal): LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor.
Published in: PLoS ONE

Ligand: R-spondin-4 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Published in: Nature

Ligand: R-spondin-3 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Published in: Nature

Ligand: R-spondin-3 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 8.770000457763672 pIC50
Reference (Journal): LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor.
Published in: PLoS ONE

Ligand: R-spondin-3 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
Published in: Proc Natl Acad Sci USA

Ligand: R-spondin-2 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
Published in: Proc Natl Acad Sci USA

Ligand: R-spondin-2 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Published in: Nature

Ligand: R-spondin-2 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 9.300000190734863 pIC50
Reference (Journal): LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor.
Published in: PLoS ONE

Ligand: R-spondin-1 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 8.479999542236328 pIC50
Reference (Journal): LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor.
Published in: PLoS ONE

Ligand: R-spondin-1 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Published in: Nature

Ligand: R-spondin-1 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
Published in: Proc Natl Acad Sci USA