dwb2023/gtopdb-target-family-interaction-detail huggingface dataset:
Target family: SLC12 family of cation-coupled chloride transporters (type: transporter)
Target: K-Cl cotransporter 3

Ligand: DIOA (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity:  -
Target family: SLC12 family of cation-coupled chloride transporters (type: transporter)
Target: K-Cl cotransporter 2

Ligand: VU0240551 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.25 pIC50
Reference (Journal): Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2.
Published in: Proc Natl Acad Sci USA

Ligand: DIOA (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity:  -
Target family: SLC12 family of cation-coupled chloride transporters (type: transporter)
Target: K-Cl cotransporter 1

Ligand: DIOA (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity:  -
Target family: SLC12 family of cation-coupled chloride transporters (type: transporter)
Target: Basolateral Na-K-Cl symporter

Ligand: furosemide (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1966)
Primary target: no
Median affinity: 5.130000114440918 pIC50
Reference (Journal): Rat NKCC2/NKCC1 cotransporter selectivity for loop diuretic drugs.
Published in: Naunyn Schmiedebergs Arch Pharmacol

Ligand: bumetanide (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1983)
Primary target: no
Median affinity: 5.599999904632568 pIC50
Reference (Journal): Rat NKCC2/NKCC1 cotransporter selectivity for loop diuretic drugs.
Published in: Naunyn Schmiedebergs Arch Pharmacol
Target family: SLC13 family of sodium-dependent sulphate/carboxylate transporters (type: transporter)
Target: Na<sup>+</sup>/citrate cotransporter

Ligand: PF-06649298 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.400000095367432 pIC50
Reference (Journal): Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5).
Published in: Sci Rep

Ligand: PF-06761281 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.289999961853027 pIC50
Reference (Journal): Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.
Published in: J Med Chem

Ligand: ETG-5773 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.800000190734863 pIC50
Reference (Journal): A Novel and Cross-Species Active Mammalian INDY (NaCT) Inhibitor Ameliorates Hepatic Steatosis in Mice with Diet-Induced Obesity.
Published in: Metabolites

Ligand: compound 7 [PMID: 37428122] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.300000190734863 pIC50
Reference (Journal): Opportunities and Challenges for Inhibitors Targeting Citrate Transport and Metabolism in Drug Discovery.
Published in: J Med Chem

Ligand: BI01383298 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.25 pIC50
Reference (Webpage): BI01383298
Target family: SLC14 family of facilitative urea transporters (type: transporter)
Target: Erythrocyte urea transporter

Ligand: compound 1a [PMID: 23597791] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.599999904632568 pIC50
Reference (Journal): 1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): new analogs and binding model.
Published in: Bioorg Med Chem Lett

Ligand: compound 8ay [PMID: 29589443] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.699999809265137 pIC50
Reference (Journal): Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1.
Published in: J Med Chem
Target family: SLC14 family of facilitative urea transporters (type: transporter)
Target: Kidney urea transporter

Ligand: compound 8ay [PMID: 29589443] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.820000171661377 pIC50
Reference (Journal): Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1.
Published in: J Med Chem
Target family: SLC14 family of facilitative urea transporters (type: transporter)
Target: Erythrocyte urea transporter

Ligand: compound 1a [PMID: 23597791] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 7.960000038146973 pIC50
Reference (Journal): 1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): new analogs and binding model.
Published in: Bioorg Med Chem Lett
Target family: SLC15 family of peptide transporters (type: transporter)
Target: Peptide transporter 3

Ligand: [14C]histidine (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Cloning of a lymphatic peptide/histidine transporter.
Published in: Biochem J

Ligand: [3H]histidine (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Cloning of a lymphatic peptide/histidine transporter.
Published in: Biochem J
Target family: SLC15 family of peptide transporters (type: transporter)
Target: Peptide transporter 4

Ligand: AJ2-30 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.739999771118164 pIC50
Reference (Journal): Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity.
Published in: Nat Chem Biol

Ligand: [14C]histidine (Synthetic organic)
Interaction type: None
Action: Binding
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Semi-Mechanistic Population Pharmacokinetic Modeling of L-Histidine Disposition and Brain Uptake in Wildtype and Pht1 Null Mice.
Published in: Pharm Res

Ligand: [14C]histidine (Synthetic organic)
Interaction type: None
Action: Binding
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): A novel role for PHT1 in the disposition of l-histidine in brain: In vitro slice and in vivo pharmacokinetic studies in wildtype and Pht1 null mice.
Published in: Biochem Pharmacol

Ligand: [14C]histidine (Synthetic organic)
Interaction type: None
Action: Binding
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Cloning and functional expression of a brain peptide/histidine transporter.
Published in: J Biol Chem

Ligand: [3H]histidine (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Expression profile and functional activity of peptide transporters in prostate cancer cells.
Published in: Mol Pharm

Ligand: [3H]histidine (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): The functional evaluation of human peptide/histidine transporter 1 (hPHT1) in transiently transfected COS-7 cells.
Published in: Eur J Pharm Sci

Ligand: [3H]histidine (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Circumvention of P-gp and MRP2 mediated efflux of lopinavir by a histidine based dipeptide prodrug.
Published in: Int J Pharm

Ligand: [3H]histidine (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): A novel role for PHT1 in the disposition of l-histidine in brain: In vitro slice and in vivo pharmacokinetic studies in wildtype and Pht1 null mice.
Published in: Biochem Pharmacol
Target family: SLC15 family of peptide transporters (type: transporter)
Target: Peptide transporter 1

Ligand: [11C]GlySar (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Cancer detection using a PET tracer, 11C-glycylsarcosine, targeted to H+/peptide transporter.
Published in: J Nucl Med

Ligand: Lys[Z(NO2)]-Val (Peptide)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.699999809265137 pKi
Reference (Journal): Peptide transporter structure reveals binding and action mechanism of a potent PEPT1 and PEPT2 inhibitor.
Published in: Commun Chem

Ligand: Lys[Z(NO2)]-Val (Peptide)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.699999809265137 pKi
Reference (Journal): Analysis of the transport properties of side chain modified dipeptides at the mammalian peptide transporter PEPT1.
Published in: Eur J Pharm Sci

Ligand: Lys[Z(NO2)]-Pro (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  pKi
Reference (Journal): A novel inhibitor of the mammalian peptide transporter PEPT1.
Published in: Biochemistry

Ligand: Lys[Z(NO2)]-Lys[Z(NO2)] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 4.900000095367432 pKi
Reference (Journal): The renal type H+/peptide symporter PEPT2: structure-affinity relationships.
Published in: Amino Acids

Ligand: glycyl-[13C3]-sarcosine (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Rapid and Sensitive Quantification of Intracellular Glycyl-Sarcosine for Semi-High-Throughput Screening for Inhibitors of PEPT-1.
Published in: Pharmaceutics

Ligand: 4-AMBA (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 2.299999952316284 pKi
Reference (Journal): Transport of the photodynamic therapy agent 5-aminolevulinic acid by distinct H+-coupled nutrient carriers coexpressed in the small intestine.
Published in: J Pharmacol Exp Ther

Ligand: 4-AMBA (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 2.299999952316284 pKi
Reference (Journal): Activation of vagal afferents in the rat duodenum by protein digests requires PepT1.
Published in: J Nutr
Target family: SLC16 family of monocarboxylate transporters (type: transporter)
Target: Monocarboxylate transporter 2

Ligand: BAY-8002 (Synthetic organic)
Interaction type: Inhibitor
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8.300000190734863 pIC50
Reference (Journal): Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance.
Published in: Mol Cancer Ther
Target family: SLC16 family of monocarboxylate transporters (type: transporter)
Target: Monocarboxylate transporter 1

Ligand: AZD3965 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.489999771118164 pKi
Reference (Journal): Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt's lymphoma anti-tumor activity.
Published in: Oncotarget

Ligand: BAY-8002 (Synthetic organic)
Interaction type: Inhibitor
Action: None
Ligand approved: no
Primary target: no
Median affinity: 9 pIC50
Reference (Journal): Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance.
Published in: Mol Cancer Ther

Ligand: BAY-8002 (Synthetic organic)
Interaction type: Inhibitor
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8.300000190734863 pKi
Reference (Journal): Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance.
Published in: Mol Cancer Ther

Ligand: compound 30 [PMID: 16455256] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.319999694824219 pKi
Reference (Journal): Potent blockers of the monocarboxylate transporter MCT1: novel immunomodulatory compounds.
Published in: Bioorg Med Chem Lett
Target family: SLC16 family of monocarboxylate transporters (type: transporter)
Target: Monocarboxylate transporter 2

Ligand: 7ACC2 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.960000038146973 pIC50
Reference (Journal): Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells.
Published in: Bioorg Med Chem

Ligand: AZD3965 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.699999809265137 pKi
Reference (Journal): Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt's lymphoma anti-tumor activity.
Published in: Oncotarget
Target family: SLC16 family of monocarboxylate transporters (type: transporter)
Target: Monocarboxylate transporter 4

Ligand: compound 18n [PMID: 34382802] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 9 pIC50
Reference (Journal): Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology.
Published in: J Med Chem
Target family: SLC18 family of vesicular amine transporters (type: transporter)
Target: Vesicular monoamine transporter 2

Ligand: tetrabenazine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (2008)
Primary target: yes
Median affinity: 7 pKi
Reference (Journal): Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.
Published in: Proc Natl Acad Sci USA

Ligand: [11C]DTBZ (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity:  -

Ligand: reserpine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1955)
Primary target: yes
Median affinity: 7.900000095367432 pKi
Reference (Journal): Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.
Published in: Proc Natl Acad Sci USA

Ligand: ketanserin (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Primary target: no
Median affinity: 6.300000190734863 pKi
Reference (Journal): Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.
Published in: Proc Natl Acad Sci USA

Ligand: deutetrabenazine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (2017)
Primary target: yes
Median affinity:  -
Target family: SLC18 family of vesicular amine transporters (type: transporter)
Target: Vesicular monoamine transporter 1

Ligand: tetrabenazine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (2008)
Median affinity: 4.7 pKi
Reference (Journal): Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.
Published in: Proc Natl Acad Sci USA

Ligand: reserpine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1955)
Median affinity: 7.45 pKi
Reference (Journal): Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.
Published in: Proc Natl Acad Sci USA

Ligand: ketanserin (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Median affinity: 5.8 pKi
Reference (Journal): Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.
Published in: Proc Natl Acad Sci USA
Target family: SLC18 family of vesicular amine transporters (type: transporter)
Target: Vesicular acetylcholine transporter

Ligand: vesamicol (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.7 pKi
Reference (Journal): Vesamicol analogues as sigma ligands. Molecular determinants of selectivity at the vesamicol receptor.
Published in: Biochem Pharmacol

Ligand: [3H]vesamicol (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Median affinity: 8.4 pKd
Reference (Journal): Active transport of acetylcholine by the human vesicular acetylcholine transporter.
Published in: J Biol Chem

Ligand: [123I]iodobenzovesamicol (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Median affinity:  -

Ligand: aminobenzovesamicol (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 10.9 pKi
Reference (Journal): Vesamicol analogues as sigma ligands. Molecular determinants of selectivity at the vesamicol receptor.
Published in: Biochem Pharmacol
Target family: SLC18 family of vesicular amine transporters (type: transporter)
Target: Vesicular monoamine transporter 2

Ligand: [125I]iodovinyl-TBZ (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.1 pKd
Reference (Journal): Binding of 125I-iodovinyltetrabenazine to CNS vesicular monoamine transport sites.
Published in: Synapse

Ligand: [3H]TBZOH (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.2 pKd
Reference (Journal): Active transport of acetylcholine by the human vesicular acetylcholine transporter.
Published in: J Biol Chem

Ligand: valbenazine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (2017)
Primary target: yes
Median affinity: 6.730000019073486 pKi
Reference (Patent): Substituted 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-A]isoquinolin-2-ol compounds and methods relating thereto.

Ligand: [125I]7-azido-8-iodoketanserine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Peptide mapping of the [125I]Iodoazidoketanserin and [125I]2-N-[(3'-iodo-4'-azidophenyl)propionyl]tetrabenazine binding sites for the synaptic vesicle monoamine transporter.
Published in: J Biol Chem
Target family: SLC19 family of vitamin transporters (type: transporter)
Target: Reduced folate transporter 1

Ligand: methotrexate (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1953), EMA (2016)
Primary target: no
Median affinity: 5.329999923706055 pKi
Reference (Journal): Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues.
Published in: J Med Chem

Ligand: compound 9 [PMID: 15615544] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.550000190734863 pKi
Reference (Journal): Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues.
Published in: J Med Chem

Ligand: [3H]folic acid (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Median affinity:  -
Reference (Journal): Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in chinese hamster ovary cells.
Published in: J Biol Chem

Ligand: [3H]methotrexate (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Median affinity:  -
Reference (Journal): Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in chinese hamster ovary cells.
Published in: J Biol Chem
Target family: SLC19 family of vitamin transporters (type: transporter)
Target: Thiamine transporter 1

Ligand: [3H]thiamine (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Median affinity:  -
Reference (Journal): Cloning of the human thiamine transporter, a member of the folate transporter family.
Published in: J Biol Chem
Target family: SLC19 family of vitamin transporters (type: transporter)
Target: Thiamine transporter 2

Ligand: [3H]thiamine (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Median affinity:  -
Reference (Journal): SLC19A3 encodes a second thiamine transporter ThTr2.
Published in: Biochim Biophys Acta
Target family: SLC23 family of ascorbic acid transporters (type: transporter)
Target: Sodium-dependent vitamin C transporter 1

Ligand: [14C]ascorbic acid (Synthetic organic)
Interaction type: None
Action: Binding
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Decreased expression of the vitamin C transporter SVCT1 by ascorbic acid in a human intestinal epithelial cell line.
Published in: Br J Nutr

Ligand: phloretin (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 4.190000057220459 pKi
Reference (Journal): A family of mammalian Na+-dependent L-ascorbic acid transporters.
Published in: Nature
Target family: SLC23 family of ascorbic acid transporters (type: transporter)
Target: Sodium-dependent vitamin C transporter 2

Ligand: [14C]ascorbic acid (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Median affinity:  -
Target family: SLC24 family of sodium/potassium/calcium exchangers (type: transporter)
Target: Sodium/potassium/calcium exchanger 6

Ligand: CGP-37157 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.800000190734863 pIC50
Reference (Journal): Neuroprotective profile of pyridothiazepines with blocking activity of the mitochondrial Na(+)/Ca(2+) exchanger.
Published in: Eur J Med Chem
Target family: SLC27 family of fatty acid transporters (type: transporter)
Target: Fatty acid transport protein 1

Ligand: compound 5k [PMID: 23528296] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.340000152587891 pIC50
Reference (Journal): Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties.
Published in: Bioorg Med Chem Lett
Target family: SLC27 family of fatty acid transporters (type: transporter)
Target: Fatty acid transport protein 4

Ligand: compound 1l [PMID: 16644217] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.050000190734863 pIC50
Reference (Journal): Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4.
Published in: Bioorg Med Chem Lett
Target family: SLC28 family (type: transporter)
Target: Sodium/nucleoside cotransporter 2

Ligand: compound 48 [PMID: 25815140] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.190000057220459 pIC50
Reference (Journal): Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors.
Published in: ACS Med Chem Lett