Target family: Class A Orphans (type: gpcr)
Target: <i>MAS1</i>

Ligand: [125I]angiotensin-(1-7) (human, mouse, rat) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.08 pKd
Reference (Journal): Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.
Published in: Proc Natl Acad Sci USA

Ligand: neuropeptide FF (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 6.400000095367432 pEC50
Reference (Journal): A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.
Published in: Cell

Ligand: MBP7 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 4.440000057220459 pEC50
Reference (Journal): Identification and characterization of surrogate peptide ligand for orphan G protein-coupled receptor mas using phage-displayed peptide library.
Published in: Biochem Pharmacol

Ligand: [D-Ala7]-angiotensin(1-7) (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.3 pKi
Reference (Journal): Angiotensin (1-7) induces MAS receptor internalization.
Published in: Hypertension

Ligand: [D-Ala7]-angiotensin(1-7) (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 9.520000457763672 pIC50
Reference (Journal): Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.
Published in: Proc Natl Acad Sci USA

Ligand: CGEN-857 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 6 pEC50
Reference (Journal): Discovery and validation of novel peptide agonists for G-protein-coupled receptors.
Published in: J Biol Chem

Ligand: CGEN-857 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 6 pEC50
Reference (Journal): Vascular relaxation, antihypertensive effect, and cardioprotection of a novel peptide agonist of the MAS receptor.
Published in: Hypertension

Ligand: CGEN-856 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 6.239999771118164 pEC50
Reference (Journal): Discovery and validation of novel peptide agonists for G-protein-coupled receptors.
Published in: J Biol Chem

Ligand: CGEN-856 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 6.239999771118164 pEC50
Reference (Journal): Vascular relaxation, antihypertensive effect, and cardioprotection of a novel peptide agonist of the MAS receptor.
Published in: Hypertension

Ligand: AVE 0991 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 7.320000171661377 pIC50
Reference (Journal): Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney.
Published in: Hypertension

Ligand: AR305352 (Peptide)
Interaction type: Antagonist
Action: Inverse agonist
Ligand approved: no
Primary target: no
Median affinity: 6.78000020980835 pIC50
Reference (Journal): Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection.
Published in: Am J Physiol Heart Circ Physiol

Ligand: AR305352 (Peptide)
Interaction type: Antagonist
Action: Inverse agonist
Ligand approved: no
Primary target: no
Median affinity: 6.489999771118164 pIC50
Reference (Journal): Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection.
Published in: Am J Physiol Heart Circ Physiol

Ligand: AR291903 (Synthetic organic)
Interaction type: Antagonist
Action: Inverse agonist
Ligand approved: no
Primary target: no
Median affinity: 8 pEC50
Reference (Journal): Angiotensin (1-7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor.
Published in: Cell Signal

Ligand: AR244555 (Synthetic organic)
Interaction type: Antagonist
Action: Inverse agonist
Ligand approved: no
Primary target: no
Median affinity: 6.730000019073486 pIC50
Reference (Journal): Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection.
Published in: Am J Physiol Heart Circ Physiol

Ligand: AR244555 (Synthetic organic)
Interaction type: Antagonist
Action: Inverse agonist
Ligand approved: no
Primary target: no
Median affinity: 6.460000038146973 pIC50
Reference (Journal): Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection.
Published in: Am J Physiol Heart Circ Physiol

Ligand: AR234960 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection.
Published in: Am J Physiol Heart Circ Physiol

Ligand: AR234960 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection.
Published in: Am J Physiol Heart Circ Physiol

Ligand: AR234958 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 7.019999980926514 pEC50
Reference (Journal): Angiotensin (1-7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor.
Published in: Cell Signal

Ligand: angiotensin-(1-7) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.16 pIC50
Reference (Journal): Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.
Published in: Proc Natl Acad Sci USA

Ligand: angiotensin-(1-7) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 7.309999942779541 pKi
Reference (Journal): Angiotensin (1-7) induces MAS receptor internalization.
Published in: Hypertension