Target family: Calcium- and sodium-activated potassium channels (K<sub>Ca</sub>, K<sub>Na</sub>) (type: vgic)
Target: K<sub>Na</sub>1.1

Ligand: tetraethylammonium (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): For K+ channels, Na+ is the new Ca2+.
Published in: Trends Neurosci

Ligand: quinidine (Natural product)
Interaction type: Channel blocker
Action: None
Ligand approved: yes
Approval source: FDA (1950)
Primary target: no
Median affinity: 4 pIC50
Reference (Journal): Pharmacological activation and inhibition of Slack (Slo2.2) channels.
Published in: Neuropharmacology

Ligand: quinidine (Natural product)
Interaction type: Channel blocker
Action: None
Ligand approved: yes
Approval source: FDA (1950)
Primary target: no
Median affinity: 4 pIC50
Reference (Journal): Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP.
Published in: J Neurosci

Ligand: quinidine (Natural product)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: yes
Approval source: FDA (1950)
Primary target: no
Median affinity:  -
Reference (Journal): KCNT1 gain of function in 2 epilepsy phenotypes is reversed by quinidine.
Published in: Ann Neurol

Ligand: phorbol 12-myristate 13-acetate (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Opposite regulation of Slick and Slack K+ channels by neuromodulators.
Published in: J Neurosci

Ligand: niclosamide (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: yes
Primary target: no
Median affinity: 5.539999961853027 pEC50
Reference (Journal): The antipsychotic drug loxapine is an opener of the sodium-activated potassium channel slack (Slo2.2).
Published in: J Pharmacol Exp Ther

Ligand: Na+ (Inorganic)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  -
Reference (Journal): The sodium-activated potassium channel is encoded by a member of the Slo gene family.
Published in: Neuron

Ligand: loxapine (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: yes
Approval source: FDA (1975), EMA (2013)
Primary target: no
Median affinity: 5.360000133514404 pEC50
Reference (Journal): The antipsychotic drug loxapine is an opener of the sodium-activated potassium channel slack (Slo2.2).
Published in: J Pharmacol Exp Ther

Ligand: Cl- (Inorganic)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity:  -
Reference (Journal): The sodium-activated potassium channel is encoded by a member of the Slo gene family.
Published in: Neuron

Ligand: clofilium (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Clofilium inhibits Slick and Slack potassium channels.
Published in: Biologics

Ligand: Ca2+ (Inorganic)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 6.5 pIC50
Reference (Journal): A Na+- and Cl- -activated K+ channel in the thick ascending limb of mouse kidney.
Published in: J Gen Physiol

Ligand: Ca2+ (Inorganic)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits.
Published in: Nat Neurosci

Ligand: bithionol (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Pharmacological activation and inhibition of Slack (Slo2.2) channels.
Published in: Neuropharmacology

Ligand: bepridil (Synthetic organic)
Interaction type: Gating inhibitor
Action: None
Ligand approved: yes
Approval source: FDA (1990)
Primary target: no
Median affinity:  pIC50
Reference (Journal): Pharmacological activation and inhibition of Slack (Slo2.2) channels.
Published in: Neuropharmacology