Target family: Lanosterol biosynthesis pathway (type: enzyme)
Target: mevalonate kinase

Ligand: dimethylallyl diphosphate (Metabolite)
Interaction type: Inhibitor
Action: Competitive
Ligand approved: no
Median affinity: 4.7 pKi
Reference (Journal): Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.
Published in: J Lipid Res

Ligand: dolichol phosphate (Metabolite)
Interaction type: Inhibitor
Action: Competitive
Ligand approved: no
Primary target: no
Median affinity: 4.079999923706055 pKi
Reference (Journal): Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.
Published in: J Lipid Res

Ligand: farnesol (Natural product)
Interaction type: Inhibitor
Action: Competitive
Ligand approved: no
Median affinity: 4.14 pKi
Reference (Journal): Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.
Published in: J Lipid Res

Ligand: farnesyl thiodiphosphate (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.54 pKi
Reference (Journal): Staphylococcus aureus mevalonate kinase: isolation and characterization of an enzyme of the isoprenoid biosynthetic pathway.
Published in: J Bacteriol

Ligand: farnesyl thiodiphosphate (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.33 pKi
Reference (Journal): Staphylococcus aureus mevalonate kinase: isolation and characterization of an enzyme of the isoprenoid biosynthetic pathway.
Published in: J Bacteriol

Ligand: geranyl diphosphate (Metabolite)
Interaction type: Inhibitor
Action: Feedback inhibition
Ligand approved: no
Median affinity: 6.94 pKi
Reference (Journal): Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.
Published in: J Lipid Res

Ligand: geranyl diphosphate (Metabolite)
Interaction type: Inhibitor
Action: Feedback inhibition
Ligand approved: no
Median affinity: 5.3 pIC50
Reference (Journal): Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase.
Published in: Org Lett

Ligand: geranylgeranyl diphosphate (Metabolite)
Interaction type: Inhibitor
Action: Feedback inhibition
Ligand approved: no
Median affinity: 7.23 pKi
Reference (Journal): Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.
Published in: J Lipid Res

Ligand: isopentenyl diphosphate (Metabolite)
Interaction type: Inhibitor
Action: Feedback inhibition
Ligand approved: no
Median affinity: 4.8 pKi
Reference (Journal): Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.
Published in: J Lipid Res

Ligand: (RS)-5-diphosphomevalonate (Synthetic organic)
Interaction type: Inhibitor
Action: Feedback inhibition
Ligand approved: no
Median affinity: 3.74 pIC50
Reference (Journal): Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase.
Published in: Org Lett

Ligand: trans,trans-farnesyl diphosphate (Metabolite)
Interaction type: Inhibitor
Action: Feedback inhibition
Ligand approved: no
Median affinity: 7 pKi
Reference (Journal): Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.
Published in: J Lipid Res

Ligand: trans,trans-farnesyl diphosphate (Metabolite)
Interaction type: Inhibitor
Action: Feedback inhibition
Ligand approved: no
Median affinity: 6.46 pKi
Reference (Journal): Staphylococcus aureus mevalonate kinase: isolation and characterization of an enzyme of the isoprenoid biosynthetic pathway.
Published in: J Bacteriol

Ligand: trans,trans-farnesyl diphosphate (Metabolite)
Interaction type: Inhibitor
Action: Feedback inhibition
Ligand approved: no
Median affinity: 5.6 pKi
Reference (Journal): Purification and regulation of mevalonate kinase from rat liver.
Published in: J Biol Chem

Ligand: trans,trans-farnesyl diphosphate (Metabolite)
Interaction type: Inhibitor
Action: Feedback inhibition
Ligand approved: no
Median affinity: 7.47 pKi
Reference (Journal): Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism.
Published in: Biochemistry