Target family: Voltage-gated sodium channels (Na<sub>V</sub>) (type: vgic)
Target: Na<sub>v</sub>1.8

Ligand: veratridine (Natural product)
Interaction type: Activator
Action: None
Ligand approved: no
Median affinity:  -
Reference (Journal): A comparison of the effects of veratridine on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in isolated rat dorsal root ganglion neurons.
Published in: Pflugers Arch

Ligand: tetrodotoxin (Natural product)
Interaction type: Channel blocker
Action: Pore blocker
Ligand approved: no
Primary target: no
Median affinity: 4.199999809265137 pIC50
Reference (Journal): A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons.
Published in: Nature

Ligand: suzetrigine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8 pIC50
Reference (Patent): Substituted tetrahydrofurans as modulators of sodium channels

Ligand: PF-04885614 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.28000020980835 pIC50
Reference (Journal): Discovery and optimisation of potent and highly subtype selective Nav1.8 inhibitors with reduced cardiovascular liabilities
Published in: Med. Chem. Commun

Ligand: PF-01247324 (Synthetic organic)
Interaction type: Channel blocker
Action: Pore blocker
Ligand approved: no
Primary target: yes
Median affinity: 6.710000038146973 pIC50
Reference (Journal): A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability.
Published in: Br J Pharmacol

Ligand: LTGO-33 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.480000019073486 pIC50
Reference (Journal): Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel Na<sub>V</sub>1.8 with a Unique Mechanism of Action.
Published in: Mol Pharmacol

Ligand: lidocaine (Synthetic organic)
Interaction type: Channel blocker
Action: Pore blocker
Ligand approved: yes
Approval source: FDA (1948)
Primary target: no
Median affinity: 4 pIC50
Reference (Journal): Present status of cancer treatment in Taiwan.
Published in: Gan To Kagaku Ryoho

Ligand: lacosamide (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: yes
Approval source: EMA and FDA (2008)
Primary target: no
Median affinity: 4.800000190734863 pIC50
Reference (Journal): Differential block of sensory neuronal voltage-gated sodium channels by lacosamide [(2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide], lidocaine, and carbamazepine.
Published in: J Pharmacol Exp Ther

Ligand: funapide (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.320000171661377 pIC50
Reference (Journal): Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform Na<sub>V</sub>1.7.
Published in: J Med Chem

Ligand: batrachotoxin (Natural product)
Interaction type: Activator
Action: None
Ligand approved: no
Median affinity:  -
Reference (Journal): The poison Dart frog's batrachotoxin modulates Nav1.8.
Published in: FEBS Lett

Ligand: AM-6120 (Peptide)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6 pIC50
Reference (Journal): Discovery of Tarantula Venom-Derived Na<sub>V</sub>1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis.
Published in: J Med Chem

Ligand: ABBV-318 (Synthetic organic)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.420000076293945 pIC50
Reference (Journal): Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na<sub>v</sub>1.7/ Nav1.8 blockers for the treatment of pain.
Published in: Bioorg Med Chem

Ligand: A-803467 (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Median affinity: 8.1 pIC50
Reference (Journal): A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
Published in: Proc Natl Acad Sci USA