Target family: Voltage-gated potassium channels (K<sub>v</sub>) (type: vgic)
Target: K<SUB>v</SUB>7.1

Ligand: JNJ303 (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.199999809265137 pIC50
Reference (Journal): Blockade of the I(Ks) potassium channel: an overlooked cardiovascular liability in drug safety screening?
Published in: J Pharmacol Toxicol Methods

Ligand: L735821 (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Molecular determinants of KCNQ1 channel block by a benzodiazepine.
Published in: Mol Pharmacol

Ligand: IKs124 (Synthetic organic)
Interaction type: Channel blocker
Action: None
Median affinity: 8.1 pIC50
Reference (Journal): Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells.
Published in: J Physiol (Lond.)

Ligand: L735821 (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide.
Published in: J Med Chem

Ligand: linopirdine (Synthetic organic)
Interaction type: Inhibitor
Action: None
Ligand approved: no
Primary target: no
Median affinity: 4.400000095367432 pIC50
Reference (Journal): Molecular variants of KCNQ channels expressed in murine portal vein myocytes: a role in delayed rectifier current.
Published in: Circ Res

Ligand: mefenamic acid (Synthetic organic)
Interaction type: Activator
Action: None
Ligand approved: yes
Approval source: FDA (1967)
Median affinity:  -
Reference (Journal): MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis.
Published in: Cell

Ligand: ML277 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 6.599999904632568 pEC50
Reference (Journal): Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator.
Published in: Bioorg Med Chem Lett

Ligand: niflumic acid (Synthetic organic)
Interaction type: Activator
Action: Positive
Ligand approved: yes
Median affinity:  -
Reference (Journal): Positive regulation by chloride channel blockers of IsK channels expressed in Xenopus oocytes.
Published in: Mol Pharmacol

Ligand: R-L3 (Synthetic organic)
Interaction type: Activator
Action: None
Ligand approved: no
Median affinity: 6 pEC50
Reference (Journal): A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents.
Published in: Mol Pharmacol

Ligand: XE991 (Synthetic organic)
Interaction type: Inhibitor
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.099999904632568 pKd
Reference (Journal): Molecular basis for differential sensitivity of KCNQ and I(Ks) channels to the cognitive enhancer XE991.
Published in: Mol Pharmacol

Ligand: zinc pyrithione (Synthetic organic)
Interaction type: Activator
Action: None
Ligand approved: no
Median affinity: 5 pEC50
Reference (Journal): Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants.
Published in: Nat Chem Biol