Target family: Galanin receptors (type: gpcr)
Target: GAL<sub>2</sub> receptor

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expression of the human galanin receptor GalR2.
Published in: Biochem Biophys Res Commun

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.41 pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Characterisation of a new chimeric ligand for galanin receptors: galanin(1-13)-[D-Trp(32)]-neuropeptide Y(25-36)amide.
Published in: Regul Pept

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.28 pEC50
Reference (Journal): Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.74 pEC50
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.46 pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expression of the human galanin receptor GalR2.
Published in: Biochem Biophys Res Commun

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.29 pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.09 pEC50
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.02 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): A novel GalR2-specific peptide agonist.
Published in: Neuropeptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation.
Published in: FEBS Lett

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Galanin receptor ligands.
Published in: Neuropeptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Molecular cloning and pharmacological characterization of a new galanin receptor subtype.
Published in: Mol Pharmacol

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Molecular cloning and characterization of a new receptor for galanin.
Published in: FEBS Lett

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): M871- A Novel Peptide Antagonist Selectively Recognising the Galanin Receptor Type 2.
Published in: Int J Pept Res

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Molecular cloning and characterization of a new receptor for galanin.
Published in: FEBS Lett

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Novel galanin receptor subtype specific ligands in feeding regulation.
Published in: Neurochem Int

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors.
Published in: Proc Natl Acad Sci USA

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Cloning, pharmacological characterization and distribution of a novel galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Alarin stimulates food intake and gonadotrophin release in male rats.
Published in: Br J Pharmacol

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): A Galanin Receptor Subtype 1 Specific Agonist.
Published in: International Journal of Peptide Research and Therapeutics,

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Cloning, pharmacological characterization and distribution of a novel galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Cloning, pharmacological characterization and distribution of a novel galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(10-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pIC50
Reference (Journal): Cloning, pharmacological characterization and distribution of a novel galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(10-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pEC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(10-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.15 pKi
Reference (Journal): Cloning and expression of the human galanin receptor GalR2.
Published in: Biochem Biophys Res Commun

Ligand: galanin(10-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 5.73 pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: galanin(1-10) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.15 pKi
Reference (Journal): Cloning and expression of the human galanin receptor GalR2.
Published in: Biochem Biophys Res Commun

Ligand: galanin(1-11) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.78 pIC50
Reference (Journal): Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors.
Published in: Proc Natl Acad Sci USA

Ligand: galanin(1-12) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.19 pKi
Reference (Journal): Cloning and expression of the human galanin receptor GalR2.
Published in: Biochem Biophys Res Commun

Ligand: galanin(1-15) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.46 pKi
Reference (Journal): Cloning and expression of the human galanin receptor GalR2.
Published in: Biochem Biophys Res Commun

Ligand: galanin(1-15) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.15 pKi
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: galanin(1-15) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.14 pEC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(1-15) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.61 pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(1-15) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.19 pEC50
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: galanin(1-15) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.13 pIC50
Reference (Journal): Cloning, pharmacological characterization and distribution of a novel galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Cloning, pharmacological characterization and distribution of a novel galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.66 pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expression of the human galanin receptor GalR2.
Published in: Biochem Biophys Res Commun

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.03 pEC50
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.93 pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation.
Published in: FEBS Lett

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities.
Published in: J Med Chem

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Molecular cloning and pharmacological characterization of a new galanin receptor subtype.
Published in: Mol Pharmacol

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Molecular cloning and characterization of a new receptor for galanin.
Published in: FEBS Lett

Ligand: galanin(1-19) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.33 pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: galanin(1-20) (human) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.11 pKi
Reference (Journal): Cloning and expression of the human galanin receptor GalR2.
Published in: Biochem Biophys Res Commun

Ligand: galanin(2-11) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.78 pKi
Reference (Journal): A novel GalR2-specific peptide agonist.
Published in: Neuropeptides

Ligand: galanin(2-11) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.75 pIC50
Reference (Journal): Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors.
Published in: Proc Natl Acad Sci USA

Ligand: galanin(2-11) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.06 pKi
Reference (Journal): Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes.
Published in: Neuropeptides

Ligand: galanin(2-29) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Cloning, pharmacological characterization and distribution of a novel galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(2-29) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(2-29) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.54 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(2-29) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(2-29) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(2-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: galanin(2-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.17 pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: galanin(2-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: galanin(2-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 9.039999961853027 pKi
Reference (Journal): Cloning and expression of the human galanin receptor GalR2.
Published in: Biochem Biophys Res Commun

Ligand: galanin(2-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Molecular cloning and pharmacological characterization of a new galanin receptor subtype.
Published in: Mol Pharmacol

Ligand: galanin(2-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation.
Published in: FEBS Lett

Ligand: galanin(2-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.54 pIC50
Reference (Journal): Molecular cloning and characterization of a new receptor for galanin.
Published in: FEBS Lett

Ligand: galanin(2-30) (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expression of the human galanin receptor GalR2.
Published in: Biochem Biophys Res Commun

Ligand: galanin(2-30) (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Molecular modelling and site-directed mutagenesis of human GALR1 galanin receptor defines determinants of receptor subtype specificity.
Published in: Protein Eng

Ligand: galanin(3-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pEC50
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: galanin(3-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin(3-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: galanin(3-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(3-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pEC50
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(3-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(3-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pIC50
Reference (Journal): Cloning, pharmacological characterization and distribution of a novel galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(3-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: galanin(3-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.15 pKi
Reference (Journal): Cloning and expression of the human galanin receptor GalR2.
Published in: Biochem Biophys Res Commun

Ligand: galanin(3-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: galanin(3-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 5.66 pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: galanin(3-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation.
Published in: FEBS Lett

Ligand: galanin(3-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pIC50
Reference (Journal): Molecular cloning and characterization of a new receptor for galanin.
Published in: FEBS Lett

Ligand: galanin(3-30) (human) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.15 pKi
Reference (Journal): Cloning and expression of the human galanin receptor GalR2.
Published in: Biochem Biophys Res Commun

Ligand: galanin(5-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 6.699999809265137 pIC50
Reference (Journal): Characterization of a high-affinity galanin receptor in the rat anterior pituitary: absence of biological effect and reduced membrane binding of the antagonist M15 differentiate it from the brain/gut receptor.
Published in: Proc Natl Acad Sci USA

Ligand: galanin(5-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.15 pKi
Reference (Journal): Cloning and expression of the human galanin receptor GalR2.
Published in: Biochem Biophys Res Commun

Ligand: galanin(7-29) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.31 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(7-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.46 pEC50
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(7-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.6 pKi
Reference (Journal): Cloning and expression of the human galanin receptor GalR2.
Published in: Biochem Biophys Res Commun

Ligand: galanin(9-25) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.15 pKi
Reference (Journal): Cloning and expression of the human galanin receptor GalR2.
Published in: Biochem Biophys Res Commun

Ligand: galanin(9-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.15 pKi
Reference (Journal): Cloning and expression of the human galanin receptor GalR2.
Published in: Biochem Biophys Res Commun

Ligand: galanin(D-Trp2) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.82 pEC50
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: galanin(D-Trp2) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.47 pEC50
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(D-Trp2) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.7 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(D-Trp2) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: galanin(D-Trp2) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin-like peptide (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.62 pIC50
Reference (Journal): Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus.
Published in: J Biol Chem

Ligand: galanin-like peptide (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.62 pEC50
Reference (Journal): Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus.
Published in: J Biol Chem

Ligand: galanin-like peptide (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Pharmacological and functional characterization of galanin-like peptide fragments as potent galanin receptor agonists.
Published in: Neuropeptides

Ligand: galanin-like peptide (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Alarin stimulates food intake and gonadotrophin release in male rats.
Published in: Br J Pharmacol

Ligand: Gal-B2-C10 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.84 pKi
Reference (Journal): Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.
Published in: J Med Chem

Ligand: Gal-B2-C12 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.79 pKi
Reference (Journal): Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.
Published in: J Med Chem

Ligand: Gal-B2-C14 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.74 pKi
Reference (Journal): Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.
Published in: J Med Chem

Ligand: Gal-B2-C18 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.82 pKi
Reference (Journal): Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.
Published in: J Med Chem

Ligand: Gal-B2-C8 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.83 pKi
Reference (Journal): Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.
Published in: J Med Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.47 pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.6 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus.
Published in: J Biol Chem

Ligand: [D-Trp2]galanin-(1-29) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 8.149999618530273 pKi
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: (D-Thr6, D-Trp8,9)galanin(1-15)ol (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 5.9 pKi
Reference (Journal): Molecular cloning and pharmacological characterization of a new galanin receptor subtype.
Published in: Mol Pharmacol

Ligand: dithiipin-1,1,4,4-tetroxide analogue 7 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 4.52 pIC50
Reference (Journal): 2,3-Dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides: small molecule non-peptide antagonists of the human galanin hGAL-1 receptor.
Published in: Bioorg Med Chem

Ligand: CYM2503 (Synthetic organic)
Interaction type: Allosteric modulator
Action: Positive
Ligand approved: no
Primary target: yes
Median affinity: 9.15999984741211 pEC50
Reference (Journal): GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models.
Published in: Proc Natl Acad Sci USA

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Molecular cloning and characterization of a new receptor for galanin.
Published in: FEBS Lett

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Molecular cloning and pharmacological characterization of a new galanin receptor subtype.
Published in: Mol Pharmacol

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.52 pEC50
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 7.85 pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.03 pEC50
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.08 pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expression of the human galanin receptor GalR2.
Published in: Biochem Biophys Res Commun

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Cloning, pharmacological characterization and distribution of a novel galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: alarin (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pIC50
Reference (Journal): Alarin stimulates food intake and gonadotrophin release in male rats.
Published in: Br J Pharmacol