Target family: Voltage-gated calcium channels  (Ca<sub>V</sub>) (type: vgic)
Target: Ca<sub>v</sub>2.1

Ligand: Cd2+ (Inorganic)
Interaction type: Channel blocker
Action: None
Median affinity:  pIC50

Ligand: DW13.3 (Peptide)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Median affinity: 8.4 pEC50
Reference (Journal): Inhibition of neuronal calcium channels by a novel peptide spider toxin, DW13.3.
Published in: Mol Pharmacol

Ligand: kurtoxin (Peptide)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity: 7.8 pEC50
Reference (Journal): Kurtoxin, a gating modifier of neuronal high- and low-threshold ca channels.
Published in: J Neurosci

Ligand: mibefradil (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: yes
Approval source: FDA (1997)
Primary target: no
Median affinity: 6.5 pIC50
Reference (Journal): Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels.
Published in: Neuropharmacology

Ligand: Ni2+ (Inorganic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Median affinity:  -
Reference (Journal): Nickel block of a family of neuronal calcium channels: subtype- and subunit-dependent action at multiple sites.
Published in: J Membr Biol

Ligand: ω-agatoxin IIIA (Peptide)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 9.300000190734863 pKd
Reference (Journal): Interactions among toxins that inhibit N-type and P-type calcium channels.
Published in: J Gen Physiol

Ligand: ω-agatoxin IIIA (Peptide)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 9.300000190734863 pKd
Reference (Journal): Block of Ca channels in rat central neurons by the spider toxin omega-Aga-IIIA.
Published in: J Neurosci

Ligand: ω-agatoxin IVA (Peptide)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels.
Published in: Nat Neurosci

Ligand: ω-agatoxin IVA (Peptide)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): P-type calcium channels blocked by the spider toxin omega-Aga-IVA.
Published in: Nature

Ligand: ω-agatoxin IVB (Peptide)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 8.5 pKd
Reference (Journal): Structure and properties of omega-agatoxin IVB, a new antagonist of P-type calcium channels.
Published in: Mol Pharmacol

Ligand: ω-conotoxin CVIA (Peptide)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Median affinity: 6.1 pIC50
Reference (Journal): Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes.
Published in: J Biol Chem

Ligand: ω-conotoxin CVIB (Peptide)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Median affinity: 8 pIC50
Reference (Journal): Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes.
Published in: J Biol Chem

Ligand: ω-conotoxin CVIC (Peptide)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Median affinity: 7.5 pIC50
Reference (Journal): Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes.
Published in: J Biol Chem

Ligand: ω-conotoxin CVID (Peptide)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Median affinity: 4.2 pIC50
Reference (Journal): Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes.
Published in: J Biol Chem

Ligand: ω-conotoxin GVIA (Peptide)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Median affinity: 6 pIC50
Reference (Journal): Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes.
Published in: J Biol Chem

Ligand: ω-conotoxin MVIIC (Peptide)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes.
Published in: J Biol Chem

Ligand: ω-conotoxin MVIID (Peptide)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 9 pIC50

Ligand: ω-grammotoxin SIA (Peptide)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Isolation and pharmacological characterization of omega-grammotoxin SIA, a novel peptide inhibitor of neuronal voltage-sensitive calcium channel responses.
Published in: Mol Pharmacol

Ligand: ω-grammotoxin SIA (Peptide)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Voltage-dependent inhibition of N- and P-type calcium channels by the peptide toxin omega-grammotoxin-SIA.
Published in: Mol Pharmacol

Ligand: ω-phonetoxin-IIA (Peptide)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 9.199999809265137 pKd
Reference (Journal): ω-Phonetoxin-IIA: a calcium channel blocker from the spider Phoneutria nigriventer.
Published in: Pflugers Arch

Ligand: ω-PnTx3-3 (Peptide)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Inhibition of neuronal high-voltage activated calcium channels by the omega-phoneutria nigriventer Tx3-3 peptide toxin.
Published in: Neuropharmacology

Ligand: PnTx-3-6 (Peptide)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Median affinity: 6.6 pIC50
Reference (Journal): Inhibition of high voltage-activated calcium channels by spider toxin PnTx3-6.
Published in: J Pharmacol Exp Ther

Ligand: ziconotide (Peptide)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: yes
Approval source: FDA (2004), EMA (2005)
Median affinity: 6.3 pIC50
Reference (Journal): Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes.
Published in: J Biol Chem