Target family: Taste 2 receptors (type: gpcr)
Target: <i>TAS2R39</i>

Ligand: vanillin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 3.059999942779541 pEC50
Reference (Journal): Vanillin Activates Human Bitter Taste Receptors TAS2R14, TAS2R20, and TAS2R39.
Published in: Front Nutr

Ligand: theaflavin-3′-O-gallate (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 6.170000076293945 pEC50
Reference (Journal): The human bitter taste receptor hTAS2R39 is the primary receptor for the bitterness of theaflavins.
Published in: Biosci Biotechnol Biochem

Ligand: theaflavin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.550000190734863 pEC50
Reference (Journal): The human bitter taste receptor hTAS2R39 is the primary receptor for the bitterness of theaflavins.
Published in: Biosci Biotechnol Biochem

Ligand: scutellarein (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.389999866485596 pEC50
Reference (Journal): Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39.
Published in: J Agric Food Chem

Ligand: (±)-Equol (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.25 pEC50
Reference (Journal): Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39.
Published in: J Agric Food Chem

Ligand: phloretin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.380000114440918 pEC50
Reference (Journal): Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39.
Published in: J Agric Food Chem

Ligand: naringenin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.480000019073486 pEC50
Reference (Journal): Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39.
Published in: J Agric Food Chem

Ligand: luteolin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.139999866485596 pEC50
Reference (Journal): Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39.
Published in: J Agric Food Chem

Ligand: L-Trp-Trp-Trp (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Amino acids and peptides activate at least five members of the human bitter taste receptor family.
Published in: J Agric Food Chem

Ligand: genistein (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.309999942779541 pEC50
Reference (Journal): Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39.
Published in: J Agric Food Chem

Ligand: epigallocatechin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 3.4000000953674316 pEC50
Reference (Journal): Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39.
Published in: Biochem Biophys Res Commun

Ligand: epicatechin gallate (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.670000076293945 pEC50
Reference (Journal): The human bitter taste receptor hTAS2R39 is the primary receptor for the bitterness of theaflavins.
Published in: Biosci Biotechnol Biochem

Ligand: (-)-Epicatechin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 3.380000114440918 pEC50
Reference (Journal): Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39.
Published in: Biochem Biophys Res Commun

Ligand: datiscetin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.380000114440918 pEC50
Reference (Journal): Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39.
Published in: J Agric Food Chem

Ligand: 6-Methylflavone (Natural product)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 4.659999847412109 pIC50
Reference (Journal): 6-methoxyflavanones as bitter taste receptor blockers for hTAS2R39.
Published in: PLoS One