Target family: Taste 2 receptors (type: gpcr)
Target: <i>TAS2R46</i>

Ligand: strychnine (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 6.369999885559082 pEC50
Reference (Journal): Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium.
Published in: J Agric Food Chem

Ligand: picrotoxinin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.150000095367432 pEC50
Reference (Journal): Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium.
Published in: J Agric Food Chem

Ligand: L-Trp-Trp-Trp (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Amino acids and peptides activate at least five members of the human bitter taste receptor family.
Published in: J Agric Food Chem

Ligand: lactucopicrin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 6.460000038146973 pEC50
Reference (Journal): Overlapping activation pattern of bitter taste receptors affect sensory adaptation and food perception.
Published in: Front Nutr

Ligand: grosheimin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.25 pEC50
Reference (Journal): Receptor Polymorphism and Genomic Structure Interact to Shape Bitter Taste Perception.
Published in: PLoS Genet

Ligand: denatonium (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 3.619999885559082 pEC50
Reference (Journal): The molecular receptive ranges of human TAS2R bitter taste receptors.
Published in: Chem Senses

Ligand: colchicine (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: yes
Approval source: FDA (2009)
Primary target: no
Median affinity: 2.799999952316284 pEC50
Reference (Journal): The molecular receptive ranges of human TAS2R bitter taste receptors.
Published in: Chem Senses

Ligand: bengalensol (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.920000076293945 pEC50
Reference (Journal): Numerous Compounds Orchestrate Coffee's Bitterness.
Published in: J Agric Food Chem

Ligand: andrographolide (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.889999866485596 pEC50
Reference (Journal): Receptor Polymorphism and Genomic Structure Interact to Shape Bitter Taste Perception.
Published in: PLoS Genet

Ligand: amarogentin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 4.170000076293945 pEC50
Reference (Journal): Receptor Polymorphism and Genomic Structure Interact to Shape Bitter Taste Perception.
Published in: PLoS Genet

Ligand: absinthin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5 pEC50
Reference (Journal): Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium.
Published in: J Agric Food Chem

Ligand: 3β-hydroxydihydrocostunolide (Natural product)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 5.329999923706055 pIC50
Reference (Journal): Receptor agonism and antagonism of dietary bitter compounds.
Published in: J Neurosci