Target family: P2Y receptors (type: gpcr)
Target: P2Y<sub>4</sub> receptor

Ligand: UTPγS (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Enzymatic synthesis of UTP gamma S, a potent hydrolysis resistant agonist of P2U-purinoceptors.
Published in: Br J Pharmacol

Ligand: UTP (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 6.300000190734863 pEC50
Reference (Journal): ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor.
Published in: Mol Pharmacol

Ligand: UTP (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 5.6 pEC50
Reference (Journal): Molecular cloning and characterization of rat P2Y4 nucleotide receptor.
Published in: Br J Pharmacol

Ligand: reactive blue-2 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 4.699999809265137 pIC50
Reference (Journal): Molecular cloning and characterization of rat P2Y4 nucleotide receptor.
Published in: Br J Pharmacol

Ligand: PSB-16133 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 6.630000114440918 pIC50
Reference (Journal): Development of Potent and Selective Antagonists for the UTP-Activated P2Y<sub>4</sub> Receptor.
Published in: J Med Chem

Ligand: PPADS (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Development of selective agonists and antagonists of P2Y receptors.
Published in: Purinergic Signal

Ligand: N4-phenylethoxycytidine-5'-triphosphate (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.14 pEC50
Reference (Journal): Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.
Published in: J Med Chem

Ligand: (N)methanocarba-UTP (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 7.099999904632568 pEC50
Reference (Journal): Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors.
Published in: J Med Chem

Ligand: MRS4062 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 7.599999904632568 pEC50
Reference (Journal): Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.
Published in: J Med Chem

Ligand: MRS2927 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 7.210000038146973 pEC50
Reference (Journal): Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.
Published in: J Med Chem

Ligand: ITP (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor.
Published in: Mol Pharmacol

Ligand: ITP (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 5.1 pEC50
Reference (Journal): ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor.
Published in: Mol Pharmacol

Ligand: ITP (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Molecular cloning and characterization of rat P2Y4 nucleotide receptor.
Published in: Br J Pharmacol

Ligand: guanosine-5'-triphosphate (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 5.2 pEC50
Reference (Journal): ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor.
Published in: Mol Pharmacol

Ligand: guanosine-5'-triphosphate (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 5.6 pEC50
Reference (Journal): ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor.
Published in: Mol Pharmacol

Ligand: diquafosol (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 6.400000095367432 pEC50
Reference (Journal): P2 receptors activated by uracil nucleotides--an update.
Published in: Curr Med Chem

Ligand: denufosol (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 6.099999904632568 pEC50
Reference (Journal): Pharmacology of INS37217 [P(1)-(uridine 5')-P(4)- (2'-deoxycytidine 5')tetraphosphate, tetrasodium salt], a next-generation P2Y(2) receptor agonist for the treatment of cystic fibrosis.
Published in: J Pharmacol Exp Ther

Ligand: CTP (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 5.1 pEC50
Reference (Journal): ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor.
Published in: Mol Pharmacol

Ligand: ATP (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.369999885559082 pEC50
Reference (Journal): Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.
Published in: Biochim Biophys Acta

Ligand: ATP (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Purine and pyrimidine (P2) receptors as drug targets.
Published in: J Med Chem

Ligand: ATP (Metabolite)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 6.199999809265137 pKd
Reference (Journal): ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor.
Published in: Mol Pharmacol

Ligand: ATP (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor.
Published in: Mol Pharmacol

Ligand: ATP (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Molecular cloning and characterization of rat P2Y4 nucleotide receptor.
Published in: Br J Pharmacol

Ligand: Ap4A (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 5.9 pEC50
Reference (Journal): ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor.
Published in: Mol Pharmacol

Ligand: 2-amino-uridine-5'-monophosphate (Synthetic organic)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity: 5.3 pEC50
Reference (Journal): Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors.
Published in: J Med Chem