Target family: Carbonic anhydrases (type: enzyme)
Target: carbonic anhydrase 12

Ligand: acetazolamide (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1995)
Primary target: no
Median affinity: 8.239999771118164 pKi
Reference (Journal): Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.
Published in: Bioorg Med Chem Lett

Ligand: acetazolamide (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1995)
Primary target: no
Median affinity: 8.239999771118164 pKi
Reference (Journal): Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Published in: Bioorg Med Chem Lett

Ligand: benzolamide (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.460000038146973 pKi
Reference (Journal): Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Published in: Bioorg Med Chem Lett

Ligand: brinzolamide (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1998), EMA (2000)
Primary target: no
Median affinity: 8.520000457763672 pKi
Reference (Journal): Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Published in: Bioorg Med Chem Lett

Ligand: celecoxib (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1998)
Primary target: no
Median affinity: 7.739999771118164 pKi
Reference (Journal): Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.
Published in: Bioorg Med Chem

Ligand: chlorthalidone (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1960), UK (1998)
Primary target: no
Median affinity: 8.350000381469727 pKi
Reference (Journal): Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.
Published in: Bioorg Med Chem

Ligand: compound 5a [PMID: 31287314] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.110000133514404 pKi
Reference (Journal): Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis.
Published in: J Med Chem

Ligand: compound 5b [PMID: 31287314] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5 pKi
Reference (Journal): Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis.
Published in: J Med Chem

Ligand: diclofenamide (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1958)
Primary target: no
Median affinity: 7.300000190734863 pKi
Reference (Journal): Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Published in: Bioorg Med Chem Lett

Ligand: dorzolamide (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1994)
Primary target: no
Median affinity: 8.460000038146973 pKi
Reference (Journal): Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Published in: Bioorg Med Chem Lett

Ligand: ethoxzolamide (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Primary target: no
Median affinity: 7.659999847412109 pKi
Reference (Journal): Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Published in: Bioorg Med Chem Lett

Ligand: indisulam (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.470000267028809 pKi
Reference (Journal): Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.
Published in: Bioorg Med Chem

Ligand: methazolamide (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1959)
Primary target: no
Median affinity: 8.470000267028809 pKi
Reference (Journal): Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Published in: Bioorg Med Chem Lett

Ligand: salvianolic acid A (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.400000095367432 pKi
Reference (Journal): New natural product carbonic anhydrase inhibitors incorporating phenol moieties.
Published in: Bioorg Med Chem

Ligand: SLC-0111 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8.350000381469727 pKi
Reference (Journal): Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity.
Published in: Bioorg Med Chem Lett

Ligand: sulpiride (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Primary target: no
Median affinity: 8.40999984741211 pKi
Reference (Journal): Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Published in: Bioorg Med Chem Lett

Ligand: topiramate (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1996)
Primary target: no
Median affinity: 8.420000076293945 pKi
Reference (Journal): Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Published in: Bioorg Med Chem Lett

Ligand: valdecoxib (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (2001)
Primary target: no
Median affinity: 7.889999866485596 pKi
Reference (Journal): Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.
Published in: Bioorg Med Chem

Ligand: zonisamide (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (2000), EMA (2005)
Primary target: no
Median affinity: 4.960000038146973 pKi
Reference (Journal): Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.
Published in: Bioorg Med Chem