Target family: R4 family (type: other_protein)
Target: regulator of G-protein signaling 4

Ligand: CCG-4986 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay.
Published in: Mol Pharmacol

Ligand: CCG-4986 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face.
Published in: Biochim Biophys Acta

Ligand: CCG-4986 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986.
Published in: Mol Pharmacol

Ligand: CCG-50014 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 7.519999980926514 pIC50
Reference (Journal): Small Molecule Inhibitors of Regulator of G Protein Signalling (RGS) Proteins.
Published in: ACS Med Chem Lett

Ligand: CCG-50014 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 7.519999980926514 pIC50
Reference (Journal): A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins.
Published in: Biochemistry

Ligand: CCG-63802 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins.
Published in: Mol Pharmacol

Ligand: CCG-63808 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins.
Published in: Mol Pharmacol

Ligand: RGS4 inhibitor 11b (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 7.840000152587891 pIC50
Reference (Journal): Small Molecule Inhibitors of Regulator of G Protein Signalling (RGS) Proteins.
Published in: ACS Med Chem Lett

Ligand: (5Z)-5-[(5-bromothiophen-2-yl)methylidene]-1-methyl-2-sulfanylidene-1,3-diazinane-4,6-dione (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 4.820000171661377 pIC50
Reference (Journal): Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay.
Published in: Cell Signal

Ligand: YJ34 (Peptide)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Structure-based design, synthesis, and pharmacologic evaluation of peptide RGS4 inhibitors.
Published in: J Pept Res