Target family: Mitochondrial function/Mitochondrial electron flow (type: other_protein)
Target: Plasmodium falciparum cytochrome b

Ligand: atovaquone (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: yes
Approval source: FDA (1992)
Primary target: no
Median affinity: 8.960000038146973 pIC50
Reference (Journal): The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites.
Published in: PLoS Med

Ligand: atovaquone (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: yes
Approval source: FDA (1992)
Primary target: no
Median affinity: 9.300000190734863 pIC50
Reference (Journal): The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites.
Published in: PLoS Med

Ligand: atovaquone (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: yes
Approval source: FDA (1992)
Primary target: no
Median affinity: 10 pIC50
Reference (Journal): The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites.
Published in: PLoS Med

Ligand: atovaquone (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: yes
Approval source: FDA (1992)
Primary target: no
Median affinity: 8.850000381469727 pIC50
Reference (Journal): The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites.
Published in: PLoS Med

Ligand: atovaquone (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: yes
Approval source: FDA (1992)
Primary target: no
Median affinity: 9.220000267028809 pIC50
Reference (Journal): The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites.
Published in: PLoS Med

Ligand: compound 11c [PMID: 30613327] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.300000190734863 pIC50
Reference (Journal): Potent Antimalarial 2-Pyrazolyl Quinolone <i>bc</i><sub>1</sub> (Q<sub>i</sub>) Inhibitors with Improved Drug-like Properties.
Published in: ACS Med Chem Lett

Ligand: ELQ-300 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8.770000457763672 pIC50
Reference (Journal): Quinolone-3-diarylethers: a new class of antimalarial drug.
Published in: Sci Transl Med

Ligand: ELQ-300 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8.640000343322754 pIC50
Reference (Journal): Quinolone-3-diarylethers: a new class of antimalarial drug.
Published in: Sci Transl Med

Ligand: ELQ-300 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8.550000190734863 pIC50
Reference (Journal): Quinolone-3-diarylethers: a new class of antimalarial drug.
Published in: Sci Transl Med

Ligand: ELQ-300 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Quinolone-3-diarylethers: a new class of antimalarial drug.
Published in: Sci Transl Med

Ligand: ELQ-300 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.139999866485596 pIC50
Reference (Journal): Quinolone-3-diarylethers: a new class of antimalarial drug.
Published in: Sci Transl Med

Ligand: ELQ-300 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8.359999656677246 pIC50
Reference (Journal): Quinolone-3-diarylethers: a new class of antimalarial drug.
Published in: Sci Transl Med

Ligand: ELQ-300 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8.510000228881836 pIC50
Reference (Journal): Quinolone-3-diarylethers: a new class of antimalarial drug.
Published in: Sci Transl Med

Ligand: compound 27 [PMID: 32945666] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.519999980926514 pIC50
Reference (Journal): Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4-<i>b</i>]pyridines.
Published in: J Med Chem

Ligand: compound 27 [PMID: 32945666] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.150000095367432 pEC50
Reference (Journal): Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4-<i>b</i>]pyridines.
Published in: J Med Chem

Ligand: compound 11c [PMID: 30613327] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.820000171661377 pIC50
Reference (Journal): Potent Antimalarial 2-Pyrazolyl Quinolone <i>bc</i><sub>1</sub> (Q<sub>i</sub>) Inhibitors with Improved Drug-like Properties.
Published in: ACS Med Chem Lett

Ligand: compound 11c [PMID: 30613327] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 9.119999885559082 pIC50
Reference (Journal): Potent Antimalarial 2-Pyrazolyl Quinolone <i>bc</i><sub>1</sub> (Q<sub>i</sub>) Inhibitors with Improved Drug-like Properties.
Published in: ACS Med Chem Lett

Ligand: ELQ-300 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8.65999984741211 pIC50
Reference (Journal): Quinolone-3-diarylethers: a new class of antimalarial drug.
Published in: Sci Transl Med

Ligand: ELQ-300 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8.600000381469727 pIC50
Reference (Journal): Quinolone-3-diarylethers: a new class of antimalarial drug.
Published in: Sci Transl Med

Ligand: ELQ-300 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8.989999771118164 pEC50
Reference (Journal): Quinolone-3-diarylethers: a new class of antimalarial drug.
Published in: Sci Transl Med

Ligand: ELQ-300 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7 pIC50
Reference (Journal): Quinolone-3-diarylethers: a new class of antimalarial drug.
Published in: Sci Transl Med

Ligand: compound 11c [PMID: 30613327] (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.480000019073486 pIC50
Reference (Journal): Potent Antimalarial 2-Pyrazolyl Quinolone <i>bc</i><sub>1</sub> (Q<sub>i</sub>) Inhibitors with Improved Drug-like Properties.
Published in: ACS Med Chem Lett

Ligand: atovaquone (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: yes
Approval source: FDA (1992)
Primary target: no
Median affinity: 9.699999809265137 pIC50
Reference (Journal): The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites.
Published in: PLoS Med

Ligand: atovaquone (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: yes
Approval source: FDA (1992)
Primary target: no
Median affinity: 9.520000457763672 pIC50
Reference (Journal): The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites.
Published in: PLoS Med

Ligand: ELQ-300 (Synthetic organic)
Interaction type: None
Action: None
Ligand approved: no
Primary target: no
Median affinity: 8.739999771118164 pIC50
Reference (Journal): Quinolone-3-diarylethers: a new class of antimalarial drug.
Published in: Sci Transl Med