Target family: Class A Orphans (type: gpcr)
Target: <i>GPR84</i>

Ligand: ZQ-16 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84.
Published in: Br J Pharmacol

Ligand: undecanoic acid (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 5.1 pEC50
Reference (Journal): Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84.
Published in: J Biol Chem

Ligand: setogepram (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 3.4000000953674316 pIC50
Reference (Journal): A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84.
Published in: Am J Pathol

Ligand: PSB-17365 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: yes
Median affinity: 8.699999809265137 pEC50
Reference (Journal): 6-(Ar)Alkylamino-Substituted Uracil Derivatives: Lipid Mimetics with Potent Activity at the Orphan G Protein-Coupled Receptor 84 (GPR84).
Published in: ACS Omega

Ligand: PSB-16434 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84.
Published in: Br J Pharmacol

Ligand: PSB-1584 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 8.489999771118164 pEC50
Reference (Journal): 6-(Ar)Alkylamino-Substituted Uracil Derivatives: Lipid Mimetics with Potent Activity at the Orphan G Protein-Coupled Receptor 84 (GPR84).
Published in: ACS Omega

Ligand: PSB-1584 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 8.300000190734863 pEC50
Reference (Journal): 6-(Ar)Alkylamino-Substituted Uracil Derivatives: Lipid Mimetics with Potent Activity at the Orphan G Protein-Coupled Receptor 84 (GPR84).
Published in: ACS Omega

Ligand: PBI-4547 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 4.769999980926514 pIC50
Reference (Journal): Fatty acid mimetic PBI-4547 restores metabolic homeostasis via GPR84 in mice with non-alcoholic fatty liver disease.
Published in: Sci Rep

Ligand: OX04529 (Synthetic organic)
Interaction type: Agonist
Action: Biased agonist
Ligand approved: no
Primary target: no
Median affinity: 10.739999771118164 pEC50
Reference (Journal): Development of Highly Potent, G-Protein Pathway Biased, Selective, and Orally Bioavailable GPR84 Agonists.
Published in: J Med Chem

Ligand: lauric acid (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 5.05 pEC50
Reference (Journal): Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84.
Published in: J Biol Chem

Ligand: GLPG1205 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Patent): Novel dihydropyrimidinoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders

Ligand: Embelin (Natural product)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84.
Published in: Br J Pharmacol

Ligand: DL-175 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 7.909999847412109 pEC50
Reference (Journal): Development of Highly Potent, G-Protein Pathway Biased, Selective, and Orally Bioavailable GPR84 Agonists.
Published in: J Med Chem

Ligand: DL-175 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 7.909999847412109 pEC50
Reference (Journal): Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84.
Published in: Br J Pharmacol

Ligand: DIM (Synthetic organic)
Interaction type: Allosteric modulator
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84.
Published in: Br J Pharmacol

Ligand: decanoic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Screening β-Arrestin Recruitment for the Identification of Natural Ligands for Orphan G-Protein-Coupled Receptors.
Published in: J Biomol Screen

Ligand: decanoic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84.
Published in: J Biol Chem

Ligand: 6-nonylpyridine-2,4-diol (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84.
Published in: Br J Pharmacol

Ligand: 6-n-octylaminouracil (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7 pEC50
Reference (Journal): Medium-chain Fatty Acid-sensing Receptor, GPR84, Is a Proinflammatory Receptor.
Published in: J Biol Chem

Ligand: 3-hydroxylauric acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 4.9 pEC50
Reference (Journal): Medium-chain Fatty Acid-sensing Receptor, GPR84, Is a Proinflammatory Receptor.
Published in: J Biol Chem

Ligand: 3-hydroxy capric acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 3.6 pEC50
Reference (Journal): Medium-chain Fatty Acid-sensing Receptor, GPR84, Is a Proinflammatory Receptor.
Published in: J Biol Chem

Ligand: 2-hydroxylauric acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5 pEC50
Reference (Journal): Medium-chain Fatty Acid-sensing Receptor, GPR84, Is a Proinflammatory Receptor.
Published in: J Biol Chem

Ligand: 2-hydroxy capric acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 4.5 pEC50
Reference (Journal): Medium-chain Fatty Acid-sensing Receptor, GPR84, Is a Proinflammatory Receptor.
Published in: J Biol Chem