Target family: 1C. Peroxisome proliferator-activated receptors (type: nhr)
Target: Peroxisome proliferator-activated receptor-&beta;/&delta;

Ligand: tretinoin (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: yes
Approval source: FDA (1995)
Primary target: no
Median affinity: 7.800000190734863 pKd
Reference (Journal): Retinoic acid is a high affinity selective ligand for the peroxisome proliferator-activated receptor beta/delta.
Published in: J Biol Chem

Ligand: seladelpar (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: yes
Median affinity: 8.720000267028809 pEC50
Reference (Journal): Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists.
Published in: Bioorg Med Chem Lett

Ligand: (R)-16 [PMID: 32267688] (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 6.090000152587891 pEC50
Reference (Journal): A Selective Modulator of Peroxisome Proliferator-Activated Receptor γ with an Unprecedented Binding Mode.
Published in: J Med Chem

Ligand: lanifibranor (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 6.059999942779541 pEC50
Reference (Journal): Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) &#x3b1;/&#x3b3;/&#x3b4; Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate.
Published in: J Med Chem

Ligand: L-796449 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.7 pKi
Reference (Journal): Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes.
Published in: J Med Chem

Ligand: L-796449 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.7 pKi
Reference (Journal): Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects.
Published in: J Biol Chem

Ligand: L-783483 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9 pKd
Reference (Journal): Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects.
Published in: J Biol Chem

Ligand: L-165041 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 8.199999809265137 pKi
Reference (Journal): Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects.
Published in: J Biol Chem

Ligand: L-165041 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 8.199999809265137 pKi
Reference (Journal): The PPARs: from orphan receptors to drug discovery.
Published in: J Med Chem

Ligand: GW9578 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.9 pEC50
Reference (Journal): Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis.
Published in: Bioorg Med Chem Lett

Ligand: GW501516 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 9 pEC50
Reference (Journal): A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport.
Published in: Proc Natl Acad Sci USA

Ligand: GW2433 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 6.599999904632568 pEC50
Reference (Journal): The PPARs: from orphan receptors to drug discovery.
Published in: J Med Chem

Ligand: GW2433 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 6.599999904632568 pEC50
Reference (Journal): Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library.
Published in: Chem Biol

Ligand: GW0742X (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9 pIC50
Reference (Journal): Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.
Published in: Bioorg Med Chem Lett

Ligand: GW0742X (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9 pIC50
Reference (Journal): The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice.
Published in: Atherosclerosis