Target family: Alpha subfamily (type: enzyme)
Target: protein kinase C beta

Ligand: PKCbeta inhibitor (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8.300000190734863 pIC50
Reference (Journal): Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors.
Published in: Bioorg Med Chem Lett

Ligand: ingenol mebutate (Natural product)
Interaction type: Activator
Action: Activation
Ligand approved: yes
Approval source: FDA & EMA (2012)
Primary target: no
Median affinity: 9.979999542236328 pKi
Reference (Journal): Characterization of the interaction of ingenol 3-angelate with protein kinase C.
Published in: Cancer Res

Ligand: Gö 6983 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8.149999618530273 pIC50
Reference (Journal): Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes.
Published in: FEBS Lett

Ligand: GF109203X (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.800000190734863 pIC50
Reference (Journal): The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.
Published in: J Biol Chem

Ligand: enzastaurin (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 7.519999980926514 pIC50
Reference (Journal): Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta.
Published in: Bioorg Med Chem Lett

Ligand: CGP53353 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.400000095367432 pIC50
Reference (Journal): A carboxy-terminal deletion mutant of protein kinase C beta II inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells.
Published in: Mol Endocrinol

Ligand: bisindolylmaleimide IV (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 6.670000076293945 pIC50
Reference (Journal): Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors.
Published in: Bioorg Med Chem Lett

Ligand: balanol (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8 pIC50
Reference (Journal): Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A.
Published in: J Med Chem

Ligand: 7-hydroxystaurosporine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 7.539999961853027 pIC50
Reference (Journal): Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue.
Published in: Mol Pharmacol

Ligand: 10-Me-Aplog-1 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 7.920000076293945 pKi
Reference (Journal): Structure-activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity.
Published in: J Med Chem