Target family: P2X receptors (type: lgic)
Target: P2X7

Ligand: A438079 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 6.9 pIC50
Reference (Journal): Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states.
Published in: Br J Pharmacol

Ligand: A740003 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.400000095367432 pIC50
Reference (Journal): A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat.
Published in: J Pharmacol Exp Ther

Ligand: A804598 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8 pIC50

Ligand: A839977 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 7.7 pIC50
Reference (Journal): Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.
Published in: Br J Pharmacol

Ligand: A839977 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 7.7 pIC50
Reference (Journal): The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice.
Published in: Behav Brain Res

Ligand: A839977 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 7.7 pIC50
Reference (Journal): Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states.
Published in: Br J Pharmacol

Ligand: ATP (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 3.109999895095825 pEC50
Reference (Journal): Purine and pyrimidine (P2) receptors as drug targets.
Published in: J Med Chem

Ligand: AZ10606120 (Synthetic organic)
Interaction type: Allosteric modulator
Action: Negative
Ligand approved: no
Primary target: yes
Median affinity:  -
Reference (Journal): Negative and positive allosteric modulators of the P2X(7) receptor.
Published in: Br J Pharmacol

Ligand: AZ10606120 (Synthetic organic)
Interaction type: Allosteric modulator
Action: Negative
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Negative and positive allosteric modulators of the P2X(7) receptor.
Published in: Br J Pharmacol

Ligand: AZ10606120 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: yes
Median affinity: 8.850000381469727 pKd
Reference (Journal): Negative and positive allosteric modulators of the P2X(7) receptor.
Published in: Br J Pharmacol

Ligand: AZ10606120 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 8.720000267028809 pKd
Reference (Journal): Negative and positive allosteric modulators of the P2X(7) receptor.
Published in: Br J Pharmacol

Ligand: AZ11645373 (Synthetic organic)
Interaction type: Allosteric modulator
Action: Negative
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Mechanism of action of species-selective P2X(7) receptor antagonists.
Published in: Br J Pharmacol

Ligand: AZ11645373 (Synthetic organic)
Interaction type: Allosteric modulator
Action: Negative
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373.
Published in: Br J Pharmacol

Ligand: AZ11657312 (salt free) (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.800000190734863 pA2
Reference (Webpage): AZ11657312.