Target family: Galanin receptors (type: gpcr)
Target: GAL<sub>1</sub> receptor

Ligand: [2Ala]-galparan (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 5.8 pKd
Reference (Journal): A galanin-mastoparan chimeric peptide activates the Na+,K(+)-ATPase and reverses its inhibition by ouabain.
Published in: Regul Pept

Ligand: [19Lys,26Leu]-galparan (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.15 pKd
Reference (Journal): A galanin-mastoparan chimeric peptide activates the Na+,K(+)-ATPase and reverses its inhibition by ouabain.
Published in: Regul Pept

Ligand: [125I][Tyr26]galanin (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.87 pKd
Reference (Journal): Genomic organization and functional characterization of the mouse GalR1 galanin receptor.
Published in: FEBS Lett

Ligand: [125I][Tyr26]galanin (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKd
Reference (Journal): Melting of a DNA hairpin without hyperchromism.
Published in: Biochemistry

Ligand: [125I][Tyr26]galanin (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKd
Reference (Journal): Cloning, pharmacological characterization, and anatomical distribution of a rat cDNA encoding for a galanin receptor.
Published in: J Mol Neurosci

Ligand: [125I][Tyr26]galanin (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKd
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: [125I][Tyr26]galanin (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKd
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: [125I][Tyr26]galanin (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 9.819999694824219 pKd
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: [125I][Tyr26]galanin (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKd
Reference (Journal): Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells.
Published in: Brain Res Mol Brain Res

Ligand: [125I][Tyr26]galanin (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKd
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: [125I][Tyr26]galanin (human) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 10.3100004196167 pKd
Reference (Journal): Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides.
Published in: J Pharmacol Exp Ther

Ligand: [125I][Tyr26]galanin (human) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 7.829999923706055 pKd
Reference (Journal): Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides.
Published in: J Pharmacol Exp Ther

Ligand: Sch 202596 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 5.77 pKi
Reference (Journal): A new fungal metabolite, Sch 202696, with Inhibitory Activity in the Galanin Receptor GALR1 Assay.
Published in: Tetrahedreon Letters

Ligand: [Sar1, D-Ala12]galanin(1-16) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.4 pIC50
Reference (Journal): Angioleiomyoma of the patellar tendon sheath. Case report.
Published in: Am J Knee Surg

Ligand: [N-Me,des-Sar]Gal-B2 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.44 pKi
Reference (Journal): Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery.
Published in: J Med Chem

Ligand: M871 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 6.38 pKi
Reference (Journal): M871- A Novel Peptide Antagonist Selectively Recognising the Galanin Receptor Type 2.
Published in: Int J Pept Res

Ligand: M617 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.64 pKi
Reference (Journal): A Galanin Receptor Subtype 1 Specific Agonist.
Published in: International Journal of Peptide Research and Therapeutics,

Ligand: M40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides.
Published in: J Pharmacol Exp Ther

Ligand: M40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: M40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: M40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: M40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: M40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells.
Published in: Brain Res Mol Brain Res

Ligand: M40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Galanin receptor ligands.
Published in: Neuropeptides

Ligand: M40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 9.05 pIC50
Reference (Journal): Molecular cloning and characterization of a new receptor for galanin.
Published in: FEBS Lett

Ligand: M40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Genomic organization and functional characterization of the mouse GalR1 galanin receptor.
Published in: FEBS Lett

Ligand: M40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 9.3 pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: M40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 9.05 pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: M35 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.4 pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: M35 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 11 pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: M35 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Galanin receptor ligands.
Published in: Neuropeptides

Ligand: M35 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 11 pIC50
Reference (Journal): Molecular cloning and characterization of a new receptor for galanin.
Published in: FEBS Lett

Ligand: M35 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells.
Published in: Brain Res Mol Brain Res

Ligand: M35 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: M35 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: M35 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides.
Published in: J Pharmacol Exp Ther

Ligand: M35 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: M32 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: M32 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Characterisation of a new chimeric ligand for galanin receptors: galanin(1-13)-[D-Trp(32)]-neuropeptide Y(25-36)amide.
Published in: Regul Pept

Ligand: M32 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: M32 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: M242 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.6 pKi
Reference (Journal): Characterisation of a new chimeric ligand for galanin receptors: galanin(1-13)-[D-Trp(32)]-neuropeptide Y(25-36)amide.
Published in: Regul Pept

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Molecular cloning and pharmacological characterization of a new galanin receptor subtype.
Published in: Mol Pharmacol

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 9 pIC50
Reference (Journal): Molecular cloning and characterization of a new receptor for galanin.
Published in: FEBS Lett

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Galanin receptor ligands.
Published in: Neuropeptides

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 9 pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Genomic organization and functional characterization of the mouse GalR1 galanin receptor.
Published in: FEBS Lett

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides.
Published in: J Pharmacol Exp Ther

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells.
Published in: Brain Res Mol Brain Res

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: M1160 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 4.81 pKi
Reference (Journal): Novel galanin receptor subtype specific ligand in depression like behavior.
Published in: Neurochem Res

Ligand: M1153 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 5.72 pKi
Reference (Journal): Novel galanin receptor subtype specific ligands in feeding regulation.
Published in: Neurochem Int

Ligand: M1152 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 5.63 pKi
Reference (Journal): Novel galanin receptor subtype specific ligands in feeding regulation.
Published in: Neurochem Int

Ligand: M1151 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.01 pKi
Reference (Journal): Novel galanin receptor subtype specific ligands in feeding regulation.
Published in: Neurochem Int

Ligand: M1145 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 6.230000019073486 pKi
Reference (Journal): A novel GalR2-specific peptide agonist.
Published in: Neuropeptides

Ligand: J20 (galanin analogue) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.6 pKi
Reference (Journal): Novel systemically active galanin receptor 2 ligands in depression-like behavior.
Published in: J Neurochem

Ligand: J18 (galanin analogue) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.86 pKi
Reference (Journal): Novel systemically active galanin receptor 2 ligands in depression-like behavior.
Published in: J Neurochem

Ligand: GalR3ant (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 5 pKi
Reference (Journal): Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes.
Published in: Neuropeptides

Ligand: galparan (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.19 pKd
Reference (Journal): A galanin-mastoparan chimeric peptide activates the Na+,K(+)-ATPase and reverses its inhibition by ouabain.
Published in: Regul Pept

Ligand: GALP(3-32) (human) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.48 pIC50
Reference (Journal): Pharmacological and functional characterization of galanin-like peptide fragments as potent galanin receptor agonists.
Published in: Neuropeptides

Ligand: GALP(1-32) (human) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.89 pIC50
Reference (Journal): Pharmacological and functional characterization of galanin-like peptide fragments as potent galanin receptor agonists.
Published in: Neuropeptides

Ligand: galnon (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 4.93 pKi
Reference (Journal): Galnon--a low-molecular weight ligand of the galanin receptors.
Published in: Neuropeptides

Ligand: galnon (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 4.93 pKi
Reference (Journal): Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests.
Published in: Proc Natl Acad Sci USA

Ligand: galmic (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 4.47 pKi
Reference (Journal): Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests.
Published in: Proc Natl Acad Sci USA

Ligand: galmic (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 4.47 pKi
Reference (Journal): Galnon--a low-molecular weight ligand of the galanin receptors.
Published in: Neuropeptides

Ligand: Gal-(K)4 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.4 pKi
Reference (Journal): Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.
Published in: J Med Chem

Ligand: Gal-B5 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.41 pKi
Reference (Journal): Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities.
Published in: J Med Chem

Ligand: Gal-B2-MPEG4 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.3 pKi
Reference (Journal): Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.
Published in: J Med Chem

Ligand: Gal-B2-dPEG24 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.89 pKi
Reference (Journal): Incorporation of monodisperse oligoethyleneglycol amino acids into anticonvulsant analogues of galanin and neuropeptide y provides peripherally acting analgesics.
Published in: Mol Pharm

Ligand: Gal-B2-C8 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.15 pKi
Reference (Journal): Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.
Published in: J Med Chem

Ligand: Gal-B2-C18 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.4 pKi
Reference (Journal): Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.
Published in: J Med Chem

Ligand: Gal-B2-C14 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.59 pKi
Reference (Journal): Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.
Published in: J Med Chem

Ligand: Gal-B2-C12 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.85 pKi
Reference (Journal): Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.
Published in: J Med Chem

Ligand: Gal-B2-C10 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.89 pKi
Reference (Journal): Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.
Published in: J Med Chem

Ligand: Gal-B2 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.46 pKi
Reference (Journal): Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities.
Published in: J Med Chem

Ligand: galanin-like peptide (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.11 pIC50
Reference (Journal): Pharmacological and functional characterization of galanin-like peptide fragments as potent galanin receptor agonists.
Published in: Neuropeptides

Ligand: galanin-like peptide (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.35 pIC50
Reference (Journal): Alarin stimulates food intake and gonadotrophin release in male rats.
Published in: Br J Pharmacol

Ligand: galanin-like peptide (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.52 pEC50
Reference (Journal): Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus.
Published in: J Biol Chem

Ligand: galanin-like peptide (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.37 pIC50
Reference (Journal): Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus.
Published in: J Biol Chem

Ligand: galanin(D-Trp2) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin(D-Trp2) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.2 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(D-Trp2) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: galanin(7-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.17 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(7-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.61 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin(3-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: galanin(3-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 5.78 pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: galanin(3-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: galanin(3-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: galanin(3-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation.
Published in: FEBS Lett

Ligand: galanin(3-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pIC50
Reference (Journal): Molecular cloning and characterization of a new receptor for galanin.
Published in: FEBS Lett

Ligand: galanin(3-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Molecular cloning of a functional human galanin receptor.
Published in: Proc Natl Acad Sci USA

Ligand: galanin(3-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Cloning, pharmacological characterization, and anatomical distribution of a rat cDNA encoding for a galanin receptor.
Published in: J Mol Neurosci

Ligand: galanin(3-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: galanin(3-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(3-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells.
Published in: Brain Res Mol Brain Res

Ligand: galanin(3-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(3-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin(2-30) (human) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.28 pKi
Reference (Journal): Molecular modelling and site-directed mutagenesis of human GALR1 galanin receptor defines determinants of receptor subtype specificity.
Published in: Protein Eng

Ligand: galanin(2-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8 pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: galanin(2-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.14 pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: galanin(2-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Genomic organization and functional characterization of the mouse GalR1 galanin receptor.
Published in: FEBS Lett

Ligand: galanin(2-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation.
Published in: FEBS Lett

Ligand: galanin(2-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.14 pIC50
Reference (Journal): Molecular cloning and characterization of a new receptor for galanin.
Published in: FEBS Lett

Ligand: galanin(2-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Molecular cloning and pharmacological characterization of a new galanin receptor subtype.
Published in: Mol Pharmacol

Ligand: galanin(2-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: galanin(2-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: galanin(2-29) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.58 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(2-29) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells.
Published in: Brain Res Mol Brain Res

Ligand: galanin(2-29) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.52 pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(2-29) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning, pharmacological characterization, and anatomical distribution of a rat cDNA encoding for a galanin receptor.
Published in: J Mol Neurosci

Ligand: galanin(2-11) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 5.3 pKi
Reference (Journal): Galanin receptor ligands.
Published in: Neuropeptides

Ligand: galanin(2-11) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.06 pIC50
Reference (Journal): Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors.
Published in: Proc Natl Acad Sci USA

Ligand: galanin(1-19) (human) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.47 pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: galanin(1-19) (human) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.82 pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Molecular cloning of a functional human galanin receptor.
Published in: Proc Natl Acad Sci USA

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities.
Published in: J Med Chem

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Genomic organization and functional characterization of the mouse GalR1 galanin receptor.
Published in: FEBS Lett

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation.
Published in: FEBS Lett

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.57 pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.57 pIC50
Reference (Journal): Molecular cloning and characterization of a new receptor for galanin.
Published in: FEBS Lett

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning, pharmacological characterization, and anatomical distribution of a rat cDNA encoding for a galanin receptor.
Published in: J Mol Neurosci

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Molecular cloning and pharmacological characterization of a new galanin receptor subtype.
Published in: Mol Pharmacol

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides.
Published in: J Pharmacol Exp Ther

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells.
Published in: Brain Res Mol Brain Res

Ligand: galanin(1-15) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: galanin(1-15) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells.
Published in: Brain Res Mol Brain Res

Ligand: galanin(1-15) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.77 pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin(1-13)amide (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.9 pKd
Reference (Journal): A galanin-mastoparan chimeric peptide activates the Na+,K(+)-ATPase and reverses its inhibition by ouabain.
Published in: Regul Pept

Ligand: galanin(1-11) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.96 pIC50
Reference (Journal): Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors.
Published in: Proc Natl Acad Sci USA

Ligand: galanin(10-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 5.78 pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: galanin(10-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells.
Published in: Brain Res Mol Brain Res

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): A novel GalR2-specific peptide agonist.
Published in: Neuropeptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.89 pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.8 pEC50
Reference (Journal): Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides.
Published in: J Pharmacol Exp Ther

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.13 pKd
Reference (Journal): A galanin-mastoparan chimeric peptide activates the Na+,K(+)-ATPase and reverses its inhibition by ouabain.
Published in: Regul Pept

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells.
Published in: Brain Res Mol Brain Res

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides.
Published in: J Pharmacol Exp Ther

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Characterisation of a new chimeric ligand for galanin receptors: galanin(1-13)-[D-Trp(32)]-neuropeptide Y(25-36)amide.
Published in: Regul Pept

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Molecular cloning of a functional human galanin receptor.
Published in: Proc Natl Acad Sci USA

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Molecular cloning of a functional human galanin receptor.
Published in: Proc Natl Acad Sci USA

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): A Galanin Receptor Subtype 1 Specific Agonist.
Published in: International Journal of Peptide Research and Therapeutics,

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.1 pKd
Reference (Journal): Molecular cloning of a functional human galanin receptor.
Published in: Proc Natl Acad Sci USA

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Molecular cloning of a functional human galanin receptor.
Published in: Proc Natl Acad Sci USA

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Alarin stimulates food intake and gonadotrophin release in male rats.
Published in: Br J Pharmacol

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors.
Published in: Proc Natl Acad Sci USA

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Genomic organization and functional characterization of the mouse GalR1 galanin receptor.
Published in: FEBS Lett

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): M871- A Novel Peptide Antagonist Selectively Recognising the Galanin Receptor Type 2.
Published in: Int J Pept Res

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation.
Published in: FEBS Lett

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Molecular cloning and characterization of a new receptor for galanin.
Published in: FEBS Lett

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning, pharmacological characterization, and anatomical distribution of a rat cDNA encoding for a galanin receptor.
Published in: J Mol Neurosci

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Molecular cloning and pharmacological characterization of a new galanin receptor subtype.
Published in: Mol Pharmacol

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Novel galanin receptor subtype specific ligands in feeding regulation.
Published in: Neurochem Int

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Galanin receptor ligands.
Published in: Neuropeptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Molecular cloning and characterization of a new receptor for galanin.
Published in: FEBS Lett

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning, pharmacological characterization, and anatomical distribution of a rat cDNA encoding for a galanin receptor.
Published in: J Mol Neurosci

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning, pharmacological characterization, and anatomical distribution of a rat cDNA encoding for a galanin receptor.
Published in: J Mol Neurosci

Ligand: dithiipin-1,1,4,4-tetroxide analogue 7 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 6.72 pIC50
Reference (Journal): 2,3-Dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides: small molecule non-peptide antagonists of the human galanin hGAL-1 receptor.
Published in: Bioorg Med Chem

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.31 pIC50
Reference (Journal): Molecular cloning and characterization of a new receptor for galanin.
Published in: FEBS Lett

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization.
Published in: J Neurochem

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Published in: Brain Res Mol Brain Res

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides.
Published in: J Pharmacol Exp Ther

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells.
Published in: Brain Res Mol Brain Res

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
Published in: J Biol Chem

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Genomic organization and functional characterization of the mouse GalR1 galanin receptor.
Published in: FEBS Lett

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.31 pIC50
Reference (Journal): Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.
Published in: Biochem Biophys Res Commun

Ligand: alarin (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pIC50
Reference (Journal): Alarin stimulates food intake and gonadotrophin release in male rats.
Published in: Br J Pharmacol

Ligand: 2,3-dihydro-1,4-dithiin-1,1,4,4-tetroxide (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 5.570000171661377 pIC50
Reference (Journal): 2,3-Dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides: small molecule non-peptide antagonists of the human galanin hGAL-1 receptor.
Published in: Bioorg Med Chem