Target family: Voltage-gated calcium channels  (Ca<sub>V</sub>) (type: vgic)
Target: Ca<sub>v</sub>2.3

Ligand: Cd2+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Median affinity: 6.1 pIC50
Reference (Journal): Structure and functional characterization of neuronal alpha 1E calcium channel subtypes.
Published in: J Biol Chem

Ligand: DW13.3 (Peptide)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Median affinity: 7 pIC50
Reference (Journal): Inhibition of neuronal calcium channels by a novel peptide spider toxin, DW13.3.
Published in: Mol Pharmacol

Ligand: mibefradil (Synthetic organic)
Interaction type: Gating inhibitor
Action: Pore blocker
Ligand approved: yes
Approval source: FDA (1997)
Primary target: no
Median affinity: 6.400000095367432 pIC50
Reference (Journal): Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels.
Published in: Neuropharmacology

Ligand: Ni2+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 4.599999904632568 pIC50
Reference (Journal): Structure and functional characterization of neuronal alpha 1E calcium channel subtypes.
Published in: J Biol Chem

Ligand: Ni2+ (Inorganic)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Structure and functional expression of a member of the low voltage-activated calcium channel family.
Published in: Science

Ligand: Ni2+ (Inorganic)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Nickel block of a family of neuronal calcium channels: subtype- and subunit-dependent action at multiple sites.
Published in: J Membr Biol

Ligand: ω-phonetoxin-IIA (Peptide)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Median affinity: 7.2 pKd
Reference (Journal): Phoneutria nigriventer omega-phonetoxin IIA blocks the Cav2 family of calcium channels and interacts with omega-conotoxin-binding sites.
Published in: J Biol Chem

Ligand: ω-PnTx3-3 (Peptide)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Median affinity: 7.9 pIC50
Reference (Journal): Inhibition of neuronal high-voltage activated calcium channels by the omega-phoneutria nigriventer Tx3-3 peptide toxin.
Published in: Neuropharmacology

Ligand: Pb2+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Median affinity: 7 pIC50
Reference (Journal): Characteristics of block by Pb2+ of function of human neuronal L-, N-, and R-type Ca2+ channels transiently expressed in human embryonic kidney 293 cells.
Published in: Mol Pharmacol

Ligand: PnTx-3-6 (Peptide)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Median affinity: 6.9 pIC50
Reference (Journal): Inhibition of high voltage-activated calcium channels by spider toxin PnTx3-6.
Published in: J Pharmacol Exp Ther

Ligand: SNX482 (Peptide)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels.
Published in: Biophys J

Ligand: SNX482 (Peptide)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas.
Published in: Biochemistry

Ligand: SNX482 (Peptide)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): alpha(1E) subunits form the pore of three cerebellar R-type calcium channels with different pharmacological and permeation properties.
Published in: J Neurosci