Target family: 2.1.1.- Protein arginine N-methyltransferases (type: enzyme)
Target: coactivator associated arginine methyltransferase 1

Ligand: SGC2085 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 7.300000190734863 pIC50
Reference (Journal): Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening.
Published in: J Med Chem

Ligand: MS049 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 7 pKd
Reference (Journal): Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.
Published in: J Med Chem

Ligand: MS049 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 7.46999979019165 pIC50
Reference (Journal): Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.
Published in: J Med Chem

Ligand: MS023 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.639999866485596 pKi
Reference (Journal): A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.
Published in: ACS Chemical Biology

Ligand: iCARM1 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 4.909999847412109 pIC50
Reference (Journal): A CARM1 Inhibitor Potently Suppresses Breast Cancer Both In Vitro and In Vivo.
Published in: J Med Chem

Ligand: iCARM1 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.170000076293945 pKi
Reference (Journal): A CARM1 Inhibitor Potently Suppresses Breast Cancer Both In Vitro and In Vivo.
Published in: J Med Chem

Ligand: compound 43 [PMID: 34781683] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.429999828338623 pIC50
Reference (Journal): Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy.
Published in: J Med Chem

Ligand: compound 17f [PMID: 19632837] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.150000095367432 pIC50
Reference (Journal): Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)--Hit to Lead studies.
Published in: Bioorg Med Chem Lett

Ligand: BMS pyrazole inhibitor 7f (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.400000095367432 pIC50
Reference (Journal): Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1).
Published in: Bioorg Med Chem Lett

Ligand: BIIB021 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8 pIC50
Reference (Webpage): TP-064 A Chemical Probe For PRMT4