Target family: P2Y receptors (type: gpcr)
Target: P2Y<sub>14</sub> receptor

Ligand: 2-thio-UDP (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 8.720000267028809 pEC50
Reference (Journal): Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.
Published in: J Med Chem

Ligand: α.β-methylene-2-thio-UDP (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 9.039999961853027 pEC50
Reference (Journal): Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.
Published in: J Med Chem

Ligand: MRS2690 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
Published in: Purinergic Signal

Ligand: MRS2690 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor.
Published in: J Med Chem

Ligand: MRS2802 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.2 pEC50
Reference (Journal): Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.
Published in: J Med Chem

Ligand: MRS2905 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 9 pEC50
Reference (Journal): Pharmacochemistry of the platelet purinergic receptors.
Published in: Purinergic Signal

Ligand: MRS4174 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 10.100000381469727 pKi
Reference (Journal): Exploring a 2-naphthoic acid template for the structure-based design of P2Y14 receptor antagonist molecular probes.
Published in: ACS Chem Biol

Ligand: MRS4183 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 9.020000457763672 pEC50
Reference (Journal): Design, synthesis, pharmacological characterization of a fluorescent agonist of the P2Y₁₄ receptor.
Published in: Bioorg Med Chem Lett

Ligand: MRS4458 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 6.769999980926514 pIC50
Reference (Journal): Structure-Guided Modification of Heterocyclic Antagonists of the P2Y<sub>14</sub> Receptor.
Published in: J Med Chem

Ligand: MRS4478 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 6.570000171661377 pIC50
Reference (Journal): Structure-Guided Modification of Heterocyclic Antagonists of the P2Y<sub>14</sub> Receptor.
Published in: J Med Chem

Ligand: MRS4625 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.559999942779541 pIC50
Reference (Journal): P2Y<sub>14</sub> Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model.
Published in: ACS Med Chem Lett

Ligand: MRS4625 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.53000020980835 pIC50
Reference (Journal): P2Y<sub>14</sub> Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model.
Published in: ACS Med Chem Lett

Ligand: P2Y14R antagonist I-17 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 9.220000267028809 pIC50
Reference (Journal): Discovery of N-Substituted Acetamide Derivatives as Promising P2Y<sub>14</sub>R Antagonists Using Molecular Hybridization Based on Crystallographic Overlay.
Published in: J Med Chem

Ligand: PPTN (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 10.100000381469727 pKi
Reference (Journal): A Selective High-Affinity Antagonist of the P2Y14 Receptor Inhibits UDP-Glucose-Stimulated Chemotaxis of Human Neutrophils.
Published in: Mol Pharmacol

Ligand: UDP (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.5 pIC50
Reference (Journal): UDP is a competitive antagonist at the human P2Y14 receptor.
Published in: J Pharmacol Exp Ther

Ligand: UDP (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 7.130000114440918 pEC50
Reference (Journal): Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor.
Published in: Mol Pharmacol

Ligand: UDP-galactose (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 7 pEC50
Reference (Journal): A G protein-coupled receptor for UDP-glucose.
Published in: J Biol Chem

Ligand: UDP-galactose (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.6 pEC50
Reference (Journal): Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs.
Published in: Genomics

Ligand: UDP-galactose (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.1 pEC50
Reference (Journal): Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs.
Published in: Genomics

Ligand: UDP-glucose (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.6 pEC50
Reference (Journal): Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs.
Published in: Genomics

Ligand: UDP-glucose (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 7.099999904632568 pIC50
Reference (Journal): Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems.
Published in: J Pharmacol Exp Ther

Ligand: UDP-glucose (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.7 pEC50
Reference (Journal): Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs.
Published in: Genomics

Ligand: UDP-glucuronic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.2 pEC50
Reference (Journal): Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems.
Published in: J Pharmacol Exp Ther

Ligand: UDP-glucuronic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7 pEC50
Reference (Journal): Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs.
Published in: Genomics

Ligand: UDP-glucuronic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.2 pEC50
Reference (Journal): Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs.
Published in: Genomics

Ligand: UDP N-acetyl-glucosamine (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7 pEC50
Reference (Journal): Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs.
Published in: Genomics

Ligand: UDP N-acetyl-glucosamine (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6 pEC50
Reference (Journal): Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems.
Published in: J Pharmacol Exp Ther

Ligand: UDP N-acetyl-glucosamine (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.8 pEC50
Reference (Journal): Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs.
Published in: Genomics