Target family: Transient Receptor Potential channels (TRP) (type: vgic)
Target: TRPC4

Ligand: 2-APB (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -

Ligand: clemizole (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 5.190000057220459 pIC50
Reference (Journal): Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5.
Published in: Mol Pharmacol

Ligand: (-)-englerin A (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Primary target: yes
Median affinity: 7.949999809265137 pEC50
Reference (Journal): (-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels.
Published in: Angew Chem Int Ed Engl

Ligand: HC-070 (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.340000152587891 pIC50
Reference (Journal): Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice.
Published in: PLoS ONE

Ligand: La3+ (Inorganic)
Interaction type: Activator
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -

Ligand: La3+ (Inorganic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -

Ligand: M084 (Synthetic organic)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 4.989999771118164 pKi
Reference (Journal): Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases.
Published in: J Med Chem

Ligand: M084 (Synthetic organic)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.269999980926514 pIC50
Reference (Journal): Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels.
Published in: Br J Pharmacol

Ligand: ML204 (Synthetic organic)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Median affinity: 5.54 pIC50
Reference (Journal): Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
Published in: J Biol Chem

Ligand: ML204 (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Median affinity: 5.5 pIC50
Reference (Journal): Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
Published in: J Biol Chem

Ligand: niflumic acid (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: yes
Primary target: no
Median affinity:  -
Reference (Journal): TRPC4 currents have properties similar to the pacemaker current in interstitial cells of Cajal.
Published in: Am J Physiol, Cell Physiol

Ligand: Pico145 (Synthetic organic)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 9.460000038146973 pIC50
Reference (Journal): Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.
Published in: J Biol Chem

Ligand: SKF96365 (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -

Ligand: tonantzitlolone (Natural product)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 6.909999847412109 pEC50
Reference (Journal): Tonantzitlolone is a nanomolar potency activator of transient receptor potential canonical 1/4/5 channels.
Published in: Br J Pharmacol