Target family: Neurotensin receptors (type: gpcr)
Target: NTS<sub>2</sub> receptor

Ligand: xenin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: binding properties, photoaffinity labeling, and internalization mechanism.
Published in: Biochem Biophys Res Commun

Ligand: Trp11-neurotensin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: binding properties, photoaffinity labeling, and internalization mechanism.
Published in: Biochem Biophys Res Commun

Ligand: Thr10contulakin-G (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.8 pIC50
Reference (Journal): Contulakin-G, an O-glycosylated invertebrate neurotensin.
Published in: J Biol Chem

Ligand: [125I]neurotensin (human, mouse, rat) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.6 pKd
Reference (Journal): Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: binding properties, photoaffinity labeling, and internalization mechanism.
Published in: Biochem Biophys Res Commun

Ligand: [125I]neurotensin (human, mouse, rat) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.6 pKd
Reference (Journal): Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain.
Published in: J Neurosci

Ligand: [125I]neurotensin (human, mouse, rat) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.1 pIC50
Reference (Journal): Molecular cloning of a levocabastine-sensitive neurotensin binding site.
Published in: FEBS Lett

Ligand: neurotensin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.2 pIC50
Reference (Journal): Contulakin-G, an O-glycosylated invertebrate neurotensin.
Published in: J Biol Chem

Ligand: neurotensin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.8 pKi
Reference (Journal): Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2.
Published in: Mol Pharmacol

Ligand: neurotensin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: binding properties, photoaffinity labeling, and internalization mechanism.
Published in: Biochem Biophys Res Commun

Ligand: neuromedin N (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: binding properties, photoaffinity labeling, and internalization mechanism.
Published in: Biochem Biophys Res Commun

Ligand: neuromedin N (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.3 pIC50
Reference (Journal): Molecular cloning of a levocabastine-sensitive neurotensin binding site.
Published in: FEBS Lett

Ligand: meclinertant (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.4 pKi
Reference (Journal): Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2.
Published in: Mol Pharmacol

Ligand: meclinertant (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.1 pIC50
Reference (Journal): Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: binding properties, photoaffinity labeling, and internalization mechanism.
Published in: Biochem Biophys Res Commun

Ligand: levocabastine (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: yes
Approval source: FDA (1993)
Primary target: no
Median affinity: 6.800000190734863 pKi
Reference (Journal): Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain.
Published in: J Neurosci

Ligand: levocabastine (Synthetic organic)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: yes
Approval source: FDA (1993)
Median affinity: 8 pIC50
Reference (Journal): Molecular cloning of a levocabastine-sensitive neurotensin binding site.
Published in: FEBS Lett

Ligand: levocabastine (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: yes
Approval source: FDA (1993)
Median affinity:  pIC50
Reference (Journal): Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: binding properties, photoaffinity labeling, and internalization mechanism.
Published in: Biochem Biophys Res Commun

Ligand: levocabastine (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: yes
Approval source: FDA (1993)
Primary target: no
Median affinity: 6.800000190734863 pKi
Reference (Journal): Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2.
Published in: Mol Pharmacol

Ligand: JMV458 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.7 pKi
Reference (Journal): Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2.
Published in: Mol Pharmacol

Ligand: JMV457 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.8 pKi
Reference (Journal): Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2.
Published in: Mol Pharmacol

Ligand: JMV431 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7 pKd
Reference (Journal): Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2.
Published in: Mol Pharmacol

Ligand: JMV2004 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.2 pKi
Reference (Journal): Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2.
Published in: Mol Pharmacol

Ligand: [D-Trp11]neurotensin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: binding properties, photoaffinity labeling, and internalization mechanism.
Published in: Biochem Biophys Res Commun

Ligand: contulakin-G (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.1 pIC50
Reference (Journal): Contulakin-G, an O-glycosylated invertebrate neurotensin.
Published in: J Biol Chem