Target family: Free fatty acid receptors (type: gpcr)
Target: FFA1 receptor

Ligand: TUG-905 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: yes
Median affinity: 8.050000190734863 pEC50
Reference (Journal): Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties.
Published in: J Med Chem

Ligand: TUG-770 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.2 pEC50
Reference (Journal): Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes.
Published in: ACS Med Chem Lett

Ligand: TUG-424 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.5 pEC50
Reference (Journal): Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes.
Published in: J Med Chem

Ligand: setogepram (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 2.9800000190734863 pEC50
Reference (Journal): A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84.
Published in: Am J Pathol

Ligand: rosiglitazone (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: yes
Approval source: FDA (1999), EMA (2000)
Median affinity: 5.6 pEC50
Reference (Journal): A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.
Published in: Biochem Biophys Res Commun

Ligand: palmitic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.
Published in: Nature

Ligand: palmitic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.
Published in: J Biol Chem

Ligand: palmitic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.
Published in: Biochem Biophys Res Commun

Ligand: oleic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.
Published in: J Biol Chem

Ligand: oleic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.
Published in: Biochem Biophys Res Commun

Ligand: oleic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.
Published in: Nature