dwb2023/gtopdb-target-family-interaction-detail huggingface dataset:
Target family: Hydrogen sulphide synthesis (type: enzyme)
Target: Cystathionine &gamma;-lyase

Ligand: aminooxyacetic acid (Metabolite)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.960000038146973 pIC50
Reference (Journal): Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE).
Published in: Br J Pharmacol

Ligand: propargylglycine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 4.400000095367432 pIC50
Reference (Journal): Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE).
Published in: Br J Pharmacol

Ligand: β-Cyano-L-alanine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.849999904632568 pIC50
Reference (Journal): Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE).
Published in: Br J Pharmacol
Target family: Hydrogen sulphide synthesis (type: enzyme)
Target: Cystathionine &beta;-synthase

Ligand: aminooxyacetic acid (Metabolite)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.070000171661377 pIC50
Reference (Journal): Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE).
Published in: Br J Pharmacol
Target family: Hydrogen sulphide synthesis (type: enzyme)
Target: 3-Mercaptopyruvate sulfurtransferase

Ligand: I3MT-3 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.570000171661377 pIC50
Reference (Journal): Discovery and Mechanistic Characterization of Selective Inhibitors of H<sub>2</sub>S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide.
Published in: Sci Rep
Target family: Hydrogen sulphide synthesis (type: enzyme)
Target: Cystathionine &beta;-synthase

Ligand: benserazide (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Primary target: no
Median affinity: 4.519999980926514 pIC50
Reference (Journal): Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer.
Published in: Pharmacol Res
Target family: Hydrogen sulphide synthesis (type: enzyme)
Target: Cystathionine &gamma;-lyase

Ligand: aminoethoxyvinylglycine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6 pIC50
Reference (Journal): Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE).
Published in: Br J Pharmacol
Target family: Hydrolases & Lipases (type: enzyme)
Target: epoxide hydrolase 2

Ligand: PF750 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.190000057220459 pIC50
Reference (Journal): Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors.
Published in: ACS Omega
Target family: Hydrolases & Lipases (type: enzyme)
Target: butyrylcholinesterase

Ligand: bambuterol (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Median affinity: 8.5 pIC50
Reference (Journal): Cholinesterases: new roles in brain function and in Alzheimer's disease.
Published in: Neurochem Res

Ligand: physostigmine (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Median affinity:  pIC50
Reference (Journal): Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.
Published in: J Med Chem

Ligand: pyridostigmine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1955)
Primary target: no
Median affinity: 6.050000190734863 pIC50
Reference (Journal): Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine.
Published in: Bioorg Med Chem

Ligand: rivastigmine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (2000), EMA (1998)
Primary target: yes
Median affinity: 7.400000095367432 pIC50
Reference (Journal): Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.
Published in: J Med Chem

Ligand: tacrine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1993)
Primary target: yes
Median affinity: 7.199999809265137 pKi
Reference (Journal): Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Published in: J Med Chem
Target family: Hydrolases & Lipases (type: enzyme)
Target: carboxylesterase 1

Ligand: GR148672X (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 8.4 pIC50
Reference (Patent): Method of screening for triacyglycerol hydrolase inhibitors.
Target family: Hydrolases & Lipases (type: enzyme)
Target: diacylglycerol lipase &alpha;

Ligand: DH376 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.899999618530273 pIC50
Reference (Journal): Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding.
Published in: J Med Chem

Ligand: DH376 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.199999809265137 pIC50
Reference (Journal): Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition.
Published in: Proc Natl Acad Sci USA

Ligand: DO34 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.199999809265137 pIC50
Reference (Journal): Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition.
Published in: Proc Natl Acad Sci USA

Ligand: KT-109 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.639999866485596 pIC50
Reference (Journal): DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.
Published in: Nat Chem Biol

Ligand: LEI105 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.5 pIC50
Reference (Journal): Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons.
Published in: J Am Chem Soc

Ligand: LEI105 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.889999866485596 pIC50
Reference (Journal): Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons.
Published in: J Am Chem Soc

Ligand: orlistat (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1999), EMA (1998)
Primary target: no
Median affinity: 7.199999809265137 pIC50
Reference (Journal): Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain.
Published in: J Cell Biol

Ligand: RHC80267 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 4.190000057220459 pIC50
Reference (Journal): Assay and inhibition of diacylglycerol lipase activity.
Published in: Bioorg Med Chem Lett
Target family: Hydrolases & Lipases (type: enzyme)
Target: diacylglycerol lipase &beta;

Ligand: DH376 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.600000381469727 pIC50
Reference (Journal): Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition.
Published in: Proc Natl Acad Sci USA

Ligand: DO34 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.100000381469727 pIC50
Reference (Journal): Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition.
Published in: Proc Natl Acad Sci USA

Ligand: KT-109 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.090000152587891 pIC50
Reference (Journal): DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.
Published in: Nat Chem Biol

Ligand: KT-109 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.400000095367432 pIC50
Reference (Journal): DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.
Published in: Nat Chem Biol

Ligand: LEI105 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.100000381469727 pIC50
Reference (Journal): Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons.
Published in: J Am Chem Soc

Ligand: orlistat (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1999), EMA (1998)
Primary target: no
Median affinity: 7 pIC50
Reference (Journal): Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain.
Published in: J Cell Biol

Ligand: RHC80267 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  -
Target family: Hydrolases & Lipases (type: enzyme)
Target: ectonucleoside triphosphate diphosphohydrolase 1

Ligand: ARL 67156 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 4.570000171661377 pKi
Reference (Journal): Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.
Published in: J Med Chem

Ligand: perenostobart (Antibody)
Interaction type: Antibody
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Patent): Antibodies that bind CD39 and uses thereof

Ligand: PSB-0963 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.590000152587891 pKi
Reference (Journal): Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold.
Published in: J Med Chem
Target family: Hydrolases & Lipases (type: enzyme)
Target: ectonucleoside triphosphate diphosphohydrolase 2

Ligand: PSB-6426 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 5.090000152587891 pKi
Reference (Journal): Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.
Published in: J Med Chem
Target family: Hydrolases & Lipases (type: enzyme)
Target: Leukotriene A<sub>4</sub> hydrolase

Ligand: 4-OMe-ARM1 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Effect of Modifier Structure on the Activation of Leukotriene A<sub>4</sub> Hydrolase Aminopeptidase Activity.
Published in: J Med Chem

Ligand: acebilustat (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Patent): Methods of inhibiting leukotriene a4 hydrolase

Ligand: bestatin (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.400000095367432 pKi
Reference (Journal): Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes.
Published in: J Biol Chem

Ligand: compound 1a [PMID: 25692029] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.270000457763672 pKi
Reference (Journal): Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain.
Published in: Pharmacol Res Perspect

Ligand: compound 1a [PMID: 25692029] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.270000457763672 pKi
Reference (Journal): Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design.
Published in: Chem Biol

Ligand: DG-051 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7.3 pIC50
Reference (Journal): Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis.
Published in: J Med Chem

Ligand: kelatorphan (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8 pKi
Reference (Journal): Kelatorphan and related analogs: potent and selective inhibitors of leukotriene A4 hydrolase
Published in: Bioorganic and Medicinal Chemistry Letters

Ligand: LYS006 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.699999809265137 pIC50
Reference (Patent): Heteroaryl butanoic acid derivatives as lta4h inhibitors

Ligand: SC-22716 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.699999809265137 pIC50
Reference (Journal): Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase.
Published in: J Med Chem
Target family: Hydrolases & Lipases (type: enzyme)
Target: lipase E, hormone sensitive type

Ligand: compound 41 [PMID: 15026062] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 9 pIC50
Reference (Journal): Carbazates as potent inhibitors of hormone-sensitive lipase.
Published in: Bioorg Med Chem Lett
Target family: Hydrolases & Lipases (type: enzyme)
Target: lipase G, endothelial type

Ligand: compound 12 [PMID: 31990537] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.300000190734863 pIC50
Reference (Journal): Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL-C Increase In Vivo.
Published in: J Med Chem

Ligand: GSK-264220A (Synthetic organic)
Interaction type: Inhibitor
Action: Irreversible inhibition
Ligand approved: no
Median affinity: 8.9 pIC50
Reference (Journal): Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors.
Published in: Bioorg Med Chem Lett
Target family: Hydrolases & Lipases (type: enzyme)
Target: lysophospholipase 1

Ligand: ML211 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.769999980926514 pIC50
Reference (Journal): Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation.
Published in: Medchemcomm

Ligand: ML348 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.519999980926514 pKi
Reference (Journal): Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation.
Published in: Medchemcomm

Ligand: Palmostatin B (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.270000457763672 pIC50
Reference (Journal): Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation.
Published in: Medchemcomm
Target family: Hydrolases & Lipases (type: enzyme)
Target: lysophospholipase 2

Ligand: ML211 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.519999980926514 pIC50
Reference (Journal): Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation.
Published in: Medchemcomm

Ligand: ML349 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.639999866485596 pKi
Reference (Journal): Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation.
Published in: Medchemcomm

Ligand: ML349 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.920000076293945 pKi
Reference (Journal): Affinity-Based Selectivity Profiling of an In-Class Selective Competitive Inhibitor of Acyl Protein Thioesterase 2.
Published in: ACS Med Chem Lett

Ligand: Palmostatin B (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.420000076293945 pIC50
Reference (Journal): Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation.
Published in: Medchemcomm
Target family: Hydrolases & Lipases (type: enzyme)
Target: neuraminidase 1

Ligand: compound 22 [PMID: 30457869] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 4.849999904632568 pIC50
Reference (Journal): Selective Inhibitors of Human Neuraminidase 1 (NEU1).
Published in: J Med Chem
Target family: Hydrolases & Lipases (type: enzyme)
Target: neuraminidase 2

Ligand: compound 13c [PMID: 30457869] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.360000133514404 pIC50
Reference (Journal): Selective Inhibitors of Human Neuraminidase 1 (NEU1).
Published in: J Med Chem

Ligand: compound 13c [PMID: 30457869] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.679999828338623 pKi
Reference (Journal): Selective Inhibitors of Human Neuraminidase 1 (NEU1).
Published in: J Med Chem

Ligand: compound 22 [PMID: 30457869] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.889999866485596 pKi
Reference (Journal): Selective Inhibitors of Human Neuraminidase 1 (NEU1).
Published in: J Med Chem

Ligand: compound 22 [PMID: 30457869] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 5.679999828338623 pIC50
Reference (Journal): Selective Inhibitors of Human Neuraminidase 1 (NEU1).
Published in: J Med Chem
Target family: Hydrolases & Lipases (type: enzyme)
Target: nudix hydrolase 7

Ligand: NUDT7-COV-1 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 5.960000038146973 pIC50
Reference (Journal): Rapid covalent-probe discovery by electrophile fragment screening.
Published in: bioRxiv
Target family: Hydrolases & Lipases (type: enzyme)
Target: O-GlcNAcase

Ligand: LY3372689 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.630000114440918 pIC50
Reference (Patent): N-[4-fluoro-5-[[(2s,4s)-2-methyl-4-[(5-methyl-1,2,4-oxadiazol-3-yl)methoxy]-1-piperidyl]methyl]thiazol-2-yl]acetamide as oga inhibitor

Ligand: MK-8719 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.28000020980835 pEC50
Reference (Journal): Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies.
Published in: J Med Chem

Ligand: MK-8719 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.100000381469727 pKi
Reference (Journal): Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies.
Published in: J Med Chem

Ligand: thiamet-G (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.679999828338623 pKi
Reference (Journal): A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo.
Published in: Nat Chem Biol
Target family: Hydrolases & Lipases (type: enzyme)
Target: pancreatic lipase

Ligand: cetilistat (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: Japan (213)
Primary target: no
Median affinity: 8.229999542236328 pIC50
Reference (Journal): Cetilistat (ATL-962), a Novel Pancreatic Lipase Inhibitor, Ameliorates Body Weight Gain and Improves Lipid Profiles in Rats
Published in: Horm Metab Res

Ligand: cetilistat (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: Japan (213)
Primary target: no
Median affinity: 7.260000228881836 pIC50
Reference (Journal): Cetilistat (ATL-962), a Novel Pancreatic Lipase Inhibitor, Ameliorates Body Weight Gain and Improves Lipid Profiles in Rats
Published in: Horm Metab Res

Ligand: orlistat (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: yes
Approval source: FDA (1999), EMA (1998)
Primary target: yes
Median affinity: 8.899999618530273 pIC50
Reference (Journal): Inhibition of hormone sensitive lipase and pancreatic lipase by <i>Rosmarinus officinalis</i> extract and selected phenolic constituents.
Published in: Journal of Medicinal Plants Research
Target family: Hydrolases & Lipases (type: enzyme)
Target: patatin like phospholipase domain containing 2

Ligand: atglistatin (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.150000095367432 pIC50
Reference (Journal): Development of small-molecule inhibitors targeting adipose triglyceride lipase.
Published in: Nat Chem Biol