Target family: Voltage-gated potassium channels (K<sub>v</sub>) (type: vgic)
Target: K<SUB>v</SUB>1.7

Ligand: amiodarone (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: yes
Approval source: FDA (1985)
Median affinity: 4.5 pKd
Reference (Journal): Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).
Published in: Eur J Hum Genet

Ligand: capsaicin (Natural product)
Interaction type: Channel blocker
Action: None
Ligand approved: yes
Approval source: EMA & FDA (2009)
Median affinity: 4.6 pIC50
Reference (Journal): Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
Published in: J Biol Chem

Ligand: conkunitzin-S1 toxin (Peptide)
Interaction type: Channel blocker
Action: Pore blocker
Ligand approved: no
Primary target: no
Median affinity: 6.400000095367432 pIC50
Reference (Journal): Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion.
Published in: EMBO Mol Med

Ligand: CP-339818 (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Median affinity: 5 pIC50
Reference (Journal): Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
Published in: J Biol Chem

Ligand: cromakalim (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Median affinity: 3.3 pIC50
Reference (Journal): Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
Published in: J Biol Chem

Ligand: diltiazem (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: yes
Approval source: FDA (1982)
Median affinity: 4.2 pIC50
Reference (Journal): Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
Published in: J Biol Chem

Ligand: fampridine (Synthetic organic)
Interaction type: Channel blocker
Action: Pore blocker
Ligand approved: yes
Approval source: FDA (2010), EMA (2011)
Primary target: no
Median affinity: 3.799999952316284 pKd
Reference (Journal): Molecular and Functional Differences between Heart mKv1.7 Channel Isoforms.
Published in: J Gen Physiol

Ligand: fampridine (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: yes
Approval source: FDA (2010), EMA (2011)
Primary target: no
Median affinity: 3.5999999046325684 pIC50
Reference (Journal): Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
Published in: J Biol Chem

Ligand: flecainide (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: yes
Approval source: FDA (1985)
Median affinity: 5.1 pKd
Reference (Journal): Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).
Published in: Eur J Hum Genet

Ligand: margatoxin (Peptide)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Median affinity: 6.9 pIC50
Reference (Journal): Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
Published in: J Biol Chem

Ligand: nifedipine (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: yes
Approval source: FDA (1981)
Median affinity: 4.9 pIC50
Reference (Journal): Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
Published in: J Biol Chem

Ligand: noxiustoxin (Peptide)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.699999809265137 pIC50
Reference (Journal): Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
Published in: J Biol Chem

Ligand: quinidine (Natural product)
Interaction type: Channel blocker
Action: None
Ligand approved: yes
Approval source: FDA (1950)
Median affinity: 4.8 pKd
Reference (Journal): Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).
Published in: Eur J Hum Genet

Ligand: resiniferatoxin (Natural product)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Median affinity: 4.7 pIC50
Reference (Journal): Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
Published in: J Biol Chem

Ligand: ShK Toxin (Peptide)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Median affinity: 7.9 pIC50
Reference (Journal): Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
Published in: J Biol Chem

Ligand: tedisamil (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Median affinity: 4.7 pIC50
Reference (Journal): Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
Published in: J Biol Chem

Ligand: tetraethylammonium (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Median affinity: 1.1 pIC50
Reference (Journal): Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
Published in: J Biol Chem

Ligand: tetraethylammonium (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Median affinity: 4.1 pKd
Reference (Journal): Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).
Published in: Eur J Hum Genet

Ligand: verapamil (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: yes
Approval source: FDA (1981)
Median affinity: 4.8 pKd
Reference (Journal): Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).
Published in: Eur J Hum Genet