Target family: Prokineticin receptors (type: gpcr)
Target: PKR<sub>1</sub>

Ligand: IS1 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.599999904632568 pEC50
Reference (Journal): Discovery and cardioprotective effects of the first non-Peptide agonists of the G protein-coupled prokineticin receptor-1.
Published in: PLoS ONE

Ligand: triazine compound PC7 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.480000019073486 pIC50
Reference (Journal): Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain.
Published in: J Nucl Med

Ligand: triazine compound PC7 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.480000019073486 pIC50
Reference (Journal): Triazinediones as prokineticin 1 receptor antagonists. Part 1: SAR, synthesis and biological evaluation.
Published in: Bioorg Med Chem Lett

Ligand: triazine compound PC10 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 6.960000038146973 pIC50
Reference (Journal): Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain.
Published in: J Nucl Med

Ligand: triazine compound PC1 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.659999847412109 pKi
Reference (Journal): Triazine compounds as antagonists at Bv8-prokineticin receptors.
Published in: J Med Chem

Ligand: [125I]BH-MIT1 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 8.390000343322754 pIC50
Reference (Journal): Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors.
Published in: Biochem Biophys Res Commun

Ligand: prokineticin-2β (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 7.5 pIC50
Reference (Journal): Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1.
Published in: Mol Pharmacol

Ligand: prokineticin-2 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors.
Published in: Biochem Biophys Res Commun

Ligand: prokineticin-2 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1.
Published in: Mol Pharmacol

Ligand: prokineticin-1 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1.
Published in: Mol Pharmacol

Ligand: prokineticin-1 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors.
Published in: Biochem Biophys Res Commun

Ligand: MIT1 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 8.399999618530273 pIC50
Reference (Journal): Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors.
Published in: Biochem Biophys Res Commun

Ligand: IS20 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 7.360000133514404 pEC50
Reference (Journal): Discovery and cardioprotective effects of the first non-Peptide agonists of the G protein-coupled prokineticin receptor-1.
Published in: PLoS ONE