Target family: Lanosterol biosynthesis pathway (type: enzyme)
Target: geranylgeranyl diphosphate synthase

Ligand: (2E, 6E)-farnesylbisphosphonate (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7 pIC50
Reference (Journal): Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.
Published in: Bioorg Med Chem

Ligand: 3-azageranylgeranyl diphosphate (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.85 pIC50
Reference (Journal): Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents.
Published in: J Med Chem

Ligand: BPH-252 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.14 pIC50
Reference (Journal): Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents.
Published in: J Med Chem

Ligand: BPH-252 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.15 pIC50
Reference (Journal): Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.
Published in: J Med Chem

Ligand: BPH-608 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.21999979019165 pKi
Reference (Journal): Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.
Published in: Proc Natl Acad Sci USA

Ligand: BPH-628 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.14 pIC50
Reference (Journal): Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.
Published in: Proc Natl Acad Sci USA

Ligand: BPH-628 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.14 pIC50
Reference (Journal): Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.
Published in: J Med Chem

Ligand: BPH-629 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.960000038146973 pKi
Reference (Journal): Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.
Published in: Proc Natl Acad Sci USA

Ligand: BPH-675 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.150000095367432 pKi
Reference (Journal): Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.
Published in: Proc Natl Acad Sci USA

Ligand: BPH-676 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.960000038146973 pKi
Reference (Journal): Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.
Published in: Proc Natl Acad Sci USA

Ligand: BPH-715 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.55 pIC50
Reference (Journal): Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.
Published in: J Med Chem

Ligand: BPH-742 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 7 pIC50
Reference (Journal): Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.
Published in: J Med Chem

Ligand: compound 11 [PMID: 18800762] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 5.6 pIC50
Reference (Journal): Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.
Published in: J Med Chem

Ligand: compound 12 [PMID: 12014956] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.51 pIC50
Reference (Journal): Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents.
Published in: J Med Chem

Ligand: compound 14 [PMID: 18800762] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.55 pIC50
Reference (Journal): Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.
Published in: J Med Chem

Ligand: compound 16 [PMID: 18800762] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.46 pIC50
Reference (Journal): Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.
Published in: J Med Chem

Ligand: compound 19 [PMID: 18800762] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.23 pIC50
Reference (Journal): Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.
Published in: J Med Chem

Ligand: compound 47 [PMID: 18800762] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 4.56 pIC50
Reference (Journal): Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.
Published in: J Med Chem

Ligand: compound 51 [PMID: 18800762] (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 4.1 pIC50
Reference (Journal): Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.
Published in: J Med Chem

Ligand: digeranyl bisphosphonate (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6 pIC50
Reference (Journal): Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.
Published in: J Med Chem

Ligand: digeranyl bisphosphonate (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.7 pIC50
Reference (Journal): Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase.
Published in: Biochem Biophys Res Commun

Ligand: geranylgeranyl diphosphate (Metabolite)
Interaction type: Inhibitor
Action: Feedback inhibition
Ligand approved: no
Median affinity: 4.6 pKi
Reference (Journal): The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.
Published in: J Biol Chem

Ligand: minodronic acid (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 4 pIC50
Reference (Journal): Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.
Published in: J Med Chem

Ligand: minodronic acid (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Median affinity: 6.17 pIC50
Reference (Journal): Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid.
Published in: J Med Chem