Target family: Voltage-gated potassium channels (K<sub>v</sub>) (type: vgic)
Target: K<SUB>v</SUB>2.1

Ligand: HaTx1 (Peptide)
Interaction type: Gating inhibitor
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.380000114440918 pKd
Reference (Journal): An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula.
Published in: Neuron

Ligand: jingzhaotoxin-XI (Peptide)
Interaction type: Gating inhibitor
Action: None
Ligand approved: no
Median affinity: 6.1 pKd
Reference (Journal): Solution structure and functional characterization of jingzhaotoxin-XI: a novel gating modifier of both potassium and sodium channels.
Published in: Biochemistry

Ligand: linoleic acid (Metabolite)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Median affinity: 5.1 pIC50
Reference (Journal): Linoleic acid both enhances activation and blocks Kv1.5 and Kv2.1 channels by two separate mechanisms.
Published in: Am J Physiol, Cell Physiol

Ligand: linoleic acid (Metabolite)
Interaction type: Activator
Action: None
Ligand approved: no
Median affinity: 5.6 pEC50
Reference (Journal): Linoleic acid both enhances activation and blocks Kv1.5 and Kv2.1 channels by two separate mechanisms.
Published in: Am J Physiol, Cell Physiol

Ligand: Na+ (Inorganic)
Interaction type: Channel blocker
Action: Pore blocker
Ligand approved: no
Primary target: no
Median affinity: 1.600000023841858 pIC50
Reference (Journal): Internal Na+ and Mg2+ blockade of DRK1 (Kv2.1) potassium channels expressed in Xenopus oocytes. Inward rectification of a delayed rectifier.
Published in: J Gen Physiol

Ligand: RY785 (Synthetic organic)
Interaction type: Gating inhibitor
Action: None
Ligand approved: no
Primary target: no
Median affinity: 5.889999866485596 pIC50
Reference (Journal): Identification of novel and selective Kv2 channel inhibitors.
Published in: Mol Pharmacol

Ligand: RY796 (Synthetic organic)
Interaction type: Gating inhibitor
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.599999904632568 pIC50
Reference (Journal): Identification of novel and selective Kv2 channel inhibitors.
Published in: Mol Pharmacol

Ligand: ScTx1 (Peptide)
Interaction type: Gating inhibitor
Action: None
Ligand approved: no
Primary target: no
Median affinity: 7.900000095367432 pIC50
Reference (Journal): Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies.
Published in: Mol Pharmacol

Ligand: SGTx1 (Peptide)
Interaction type: Gating inhibitor
Action: None
Ligand approved: no
Primary target: no
Median affinity: 5.699999809265137 pKd
Reference (Journal): Solution structure and functional characterization of SGTx1, a modifier of Kv2.1 channel gating.
Published in: Biochemistry

Ligand: SsmTx-1 (Peptide)
Interaction type: Channel blocker
Action: Pore blocker
Ligand approved: no
Primary target: no
Median affinity: 7.400000095367432 pIC50
Reference (Journal): Isolation and characterization of SsmTx-I, a Specific Kv2.1 blocker from the venom of the centipede Scolopendra Subspinipes Mutilans L. Koch.
Published in: J Pept Sci

Ligand: tetraethylammonium (Synthetic organic)
Interaction type: Channel blocker
Action: Pore blocker
Ligand approved: no
Primary target: no
Median affinity: 2 pIC50
Reference (Journal): Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25.
Published in: Biochem J