dwb2023/gtopdb-target-family-interaction-detail huggingface dataset:
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR12</i>

Ligand: sphingosylphosphorylcholine (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development.
Published in: J Neurosci

Ligand: sphingosine 1-phosphate (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors.
Published in: Cell Signal
Target family: Class A Orphans (type: gpcr)
Target: <i>LGR4</i>

Ligand: R-spondin-4 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 10.050000190734863 pEC50
Reference (Journal): R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
Published in: Proc Natl Acad Sci USA

Ligand: R-spondin-3 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 8.65999984741211 pKd
Reference (Journal): LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.
Published in: EMBO Rep

Ligand: R-spondin-3 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 10.699999809265137 pEC50
Reference (Journal): R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
Published in: Proc Natl Acad Sci USA

Ligand: R-spondin-2 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 12.520000457763672 pEC50
Reference (Journal): R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
Published in: Proc Natl Acad Sci USA

Ligand: R-spondin-1 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 10.699999809265137 pEC50
Reference (Journal): R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
Published in: Proc Natl Acad Sci USA
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR88</i>

Ligand: RTI-13951-33 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: yes
Median affinity: 7.599999904632568 pEC50
Reference (Journal): Discovery of a Potent, Selective, and Brain-Penetrant Small Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake.
Published in: J Med Chem

Ligand: RTI-122 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 7.960000038146973 pEC50
Reference (Journal): Improvement of the Metabolic Stability of GPR88 Agonist RTI-13951-33: Design, Synthesis, and Biological Evaluation.
Published in: J Med Chem

Ligand: compound 2 [PMID: 24793972] (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 6.21999979019165 pEC50
Reference (Journal): Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor.
Published in: ACS Chem Neurosci
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR87</i>

Ligand: LPA (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.44 pEC50
Reference (Journal): Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor.
Published in: Biochem Biophys Res Commun

Ligand: LPA (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.44 pEC50
Reference (Journal): The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor.
Published in: Biochem Biophys Res Commun

Ligand: Ki16425 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  -
Reference (Journal): The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor.
Published in: Biochem Biophys Res Commun

Ligand: dioctanoylglycerol pyrophosphate (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  -
Reference (Journal): The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor.
Published in: Biochem Biophys Res Commun
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR83</i>

Ligand: Zn2+ (Inorganic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 5 pEC50
Reference (Journal): G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity.
Published in: PLoS ONE

Ligand: PEN (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 8.100000381469727 pKd
Reference (Journal): Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.
Published in: Sci Signal

Ligand: PEN (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 6.960000038146973 pEC50
Reference (Journal): Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.
Published in: Sci Signal

Ligand: PEN (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 10.739999771118164 pEC50
Reference (Journal): Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.
Published in: Sci Signal
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR75</i>

Ligand: CCL5 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.59 pEC50
Reference (Journal): RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75.
Published in: Br J Pharmacol
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR6</i>

Ligand: sphingosine 1-phosphate (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway.
Published in: Biochem Biophys Res Commun

Ligand: sphingosine 1-phosphate (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors.
Published in: Cell Signal

Ligand: example 494 [WO2014028479] parent molecule (Synthetic organic)
Interaction type: Agonist
Action: Inverse agonist
Ligand approved: no
Primary target: no
Median affinity: 8.699999809265137 pIC50
Reference (Patent): Quinoxaline derivatives as gpr6 modulators

Ligand: example 31 [WO2018183145] (Synthetic organic)
Interaction type: Agonist
Action: Inverse agonist
Ligand approved: no
Primary target: no
Median affinity: 7.099999904632568 pEC50
Reference (Patent): Piperidinyl- and piperazinyl-substituted heteroaromatic carboxamides as modulators of gpr6

Ligand: CVN424 (Synthetic organic)
Interaction type: Agonist
Action: Inverse agonist
Ligand approved: no
Primary target: no
Median affinity: 8.029999732971191 pKi
Reference (Journal): First-Time Disclosure of CVN424, a Potent and Selective GPR6 Inverse Agonist for the Treatment of Parkinson's Disease: Discovery, Pharmacological Validation, and Identification of a Clinical Candidate.
Published in: J Med Chem
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR68</i>

Ligand: Pomc (141-162) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.889999866485596 pEC50
Reference (Journal): Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors.
Published in: Cell

Ligand: OSTN (115-133) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 6.420000076293945 pEC50
Reference (Journal): Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors.
Published in: Cell

Ligand: ogerin (Synthetic organic)
Interaction type: Allosteric modulator
Action: Positive
Ligand approved: no
Primary target: no
Median affinity: 4.96999979019165 pKB
Reference (Journal): Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.
Published in: Nature

Ligand: MS48107 (Synthetic organic)
Interaction type: Allosteric modulator
Action: Positive
Ligand approved: no
Primary target: yes
Median affinity: 5.849999904632568 pKB
Reference (Journal): Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68).
Published in: J Med Chem

Ligand: lorazepam (Synthetic organic)
Interaction type: Allosteric modulator
Action: Positive
Ligand approved: yes
Approval source: FDA (1977)
Primary target: no
Median affinity:  -
Reference (Journal): Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.
Published in: Nature

Ligand: CARTPT (76-96) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 5.980000019073486 pEC50
Reference (Journal): Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors.
Published in: Cell
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR63</i>

Ligand: sphingosine 1-phosphate (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63.
Published in: Cell Signal

Ligand: dioleoylphosphatidic acid (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.3 pEC50
Reference (Journal): Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63.
Published in: Cell Signal

Ligand: dihydrosphingosine 1-phosphate (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.17 pEC50
Reference (Journal): Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63.
Published in: Cell Signal
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR61</i>

Ligand: compound 1 [PMID: 37741852] (Synthetic organic)
Interaction type: Agonist
Action: Inverse agonist
Ligand approved: no
Primary target: no
Median affinity: 8 pIC50
Reference (Journal): An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism.
Published in: Nat Commun
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR52</i>

Ligand: derivative 17 [Nakahata et al., 2018] (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 7.679999828338623 pEC50
Reference (Journal): Design and synthesis of 1-(1-benzothiophen-7-yl)-1H-pyrazole, a novel series of G protein-coupled receptor 52 (GPR52) agonists.
Published in: Bioorg Med Chem

Ligand: compound 7a [PMID: 24884590] (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 7.550000190734863 pEC50
Reference (Journal): Discovery of the first potent and orally available agonist of the orphan G-protein-coupled receptor 52.
Published in: J Med Chem
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR4</i>

Ligand: NE 52-QQ57 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 5.739999771118164 pIC50
Reference (Journal): Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis.
Published in: J Med Chem

Ligand: NE 52-QQ57 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.150000095367432 pIC50
Reference (Journal): Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis.
Published in: J Med Chem

Ligand: GPR4 antagonist 3b (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.170000076293945 pIC50
Reference (Journal): Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction.
Published in: ACS Med Chem Lett
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR3</i>

Ligand: sphingosine 1-phosphate (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors.
Published in: Cell Signal

Ligand: diphenyleneiodonium chloride (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 6 pEC50
Reference (Journal): Identification of a novel small-molecule agonist for human G protein-coupled receptor 3.
Published in: J Pharmacol Exp Ther
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR39</i>

Ligand: Zn2+ (Inorganic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  -
Reference (Journal): GPR39 signaling is stimulated by zinc ions but not by obestatin.
Published in: Endocrinology

Ligand: compound 1 [PMID: 24900608] (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example.
Published in: ACS Med Chem Lett

Ligand: compound 15 [PMID: 25313322] (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 9.100000381469727 pEC50
Reference (Journal): Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists.
Published in: ACS Med Chem Lett
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR37L1</i>

Ligand: prosaptide (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.3 pEC50
Reference (Journal): GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.
Published in: Proc Natl Acad Sci USA
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR37</i>

Ligand: prosaptide (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.15 pEC50
Reference (Journal): GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.
Published in: Proc Natl Acad Sci USA

Ligand: neuropeptide head activator (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37.
Published in: J Cell Sci
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR34</i>

Ligand: YL-365 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.769999980926514 pIC50
Reference (Journal): Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.
Published in: Biochim Biophys Acta

Ligand: lysophosphatidylserine (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position.
Published in: J Biochem

Ligand: lysophosphatidylserine (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.31 pEC50
Reference (Journal): Identification of a lysophosphatidylserine receptor on mast cells.
Published in: Biochem Biophys Res Commun

Ligand: lysophosphatidylserine (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): Identification of a lysophosphatidylserine receptor on mast cells.
Published in: Biochem Biophys Res Commun
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR32</i>

Ligand: [3H]resolvin D1 (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 9.7 pKd
Reference (Journal): Resolvin D1 binds human phagocytes with evidence for proresolving receptors.
Published in: Proc Natl Acad Sci USA

Ligand: RvD1-ME (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 11.34000015258789 pEC50
Reference (Journal): Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs.
Published in: Am J Pathol

Ligand: resolvin D1 (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 11.0600004196167 pEC50
Reference (Journal): Resolvin D1 binds human phagocytes with evidence for proresolving receptors.
Published in: Proc Natl Acad Sci USA

Ligand: LXA4 (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 9.699999809265137 pEC50
Reference (Journal): Resolvin D1 binds human phagocytes with evidence for proresolving receptors.
Published in: Proc Natl Acad Sci USA
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR31</i>

Ligand: 12S-[3H]HETE (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.31 pKd
Reference (Journal): Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid.
Published in: J Biol Chem

Ligand: 12S-HETE (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.55 pEC50
Reference (Journal): Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid.
Published in: J Biol Chem
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR19</i>

Ligand: adropin (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 8.109999656677246 pEC50
Reference (Journal): G protein-coupled receptor GPR19 regulates E-cadherin expression and invasion of breast cancer cells.
Published in: Biochim Biophys Acta
Target family: Class A Orphans (type: gpcr)
Target: <i>GPR182</i>

Ligand: adrenomedullin (Peptide)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Primary target: no
Median affinity: 8.149999618530273 pEC50
Reference (Journal): Cloning and expression of cDNA encoding a rat adrenomedullin receptor.
Published in: J Biol Chem
Target family: Class A Orphans (type: gpcr)
Target: <i>TAAR5</i>

Ligand: trimethylamine (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.52 pEC50
Reference (Journal): A second class of chemosensory receptors in the olfactory epithelium.
Published in: Nature

Ligand: dimethylethylamine (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.15 pEC50
Reference (Journal): Trace amine-associated receptors and their ligands.
Published in: Br J Pharmacol
Target family: Class A Orphans (type: gpcr)
Target: <i>TAAR4P </i>

Ligand: xylometazoline (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: yes
Median affinity:  -
Reference (Journal): Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates.
Published in: PLoS ONE

Ligand: naphazoline (Synthetic organic)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: yes
Approval source: FDA (1971, prior history not available)
Median affinity:  -
Reference (Journal): Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates.
Published in: PLoS ONE

Ligand: naphazoline (Synthetic organic)
Interaction type: Agonist
Action: Agonist
Ligand approved: yes
Approval source: FDA (1971, prior history not available)
Median affinity:  -
Reference (Journal): Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates.
Published in: PLoS ONE

Ligand: β-phenylethylamine (Metabolite)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates.
Published in: PLoS ONE

Ligand: β-phenylethylamine (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pEC50
Reference (Journal): A second class of chemosensory receptors in the olfactory epithelium.
Published in: Nature
Target family: Class A Orphans (type: gpcr)
Target: <i>TAAR3</i>

Ligand: isoamylamine (Metabolite)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5 pEC50
Reference (Journal): A second class of chemosensory receptors in the olfactory epithelium.
Published in: Nature
Target family: Class A Orphans (type: gpcr)
Target: <i>P2RY10</i>

Ligand: sphingosine 1-phosphate (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.3 pEC50
Reference (Journal): Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor.
Published in: Biochem Biophys Res Commun

Ligand: LPA (Metabolite)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.9 pEC50
Reference (Journal): Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor.
Published in: Biochem Biophys Res Commun

Ligand: JTE-013 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor.
Published in: Biochem Biophys Res Commun

Ligand: dioctanoylglycerol pyrophosphate (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor.
Published in: Biochem Biophys Res Commun