Target family: QRFP receptor (type: gpcr)
Target: QRFP receptor

Ligand: compound 25e [PMID: 25875054] (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.340000152587891 pIC50
Reference (Journal): Correction to GPR103 Antagonists Demonstrating Anorexigenic Activity in Vivo: Design and Development of Pyrrolo[2,3-c]pyridines That Mimic the C-Terminal Arg-Phe Motif of QRFP26.
Published in: J Med Chem

Ligand: compound 25e [PMID: 25875054] (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 7.340000152587891 pIC50
Reference (Journal): GPR103 antagonists demonstrating anorexigenic activity in vivo: design and development of pyrrolo[2,3-c]pyridines that mimic the C-terminal Arg-Phe motif of QRFP26.
Published in: J Med Chem

Ligand: LV-2172 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 6.789999961853027 pEC50
Reference (Journal): Rational design of a low molecular weight, stable, potent, and long-lasting GPR103 aza-β3-pseudopeptide agonist.
Published in: J Med Chem

Ligand: LV-2186 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 7.179999828338623 pEC50
Reference (Journal): Design, Synthesis, Molecular Dynamics Simulation, and Functional Evaluation of a Novel Series of 26RFa Peptide Analogues Containing a Mono- or Polyalkyl Guanidino Arginine Derivative.
Published in: J Med Chem

Ligand: LV-2211 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 6.489999771118164 pEC50
Reference (Journal): Point-Substitution of Phenylalanine Residues of 26RFa Neuropeptide: A Structure-Activity Relationship Study.
Published in: Molecules

Ligand: QRFP26 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity.
Published in: Proc Natl Acad Sci USA

Ligand: QRFP26 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.22 pEC50
Reference (Journal): Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.
Published in: J Biol Chem

Ligand: QRFP26 (26RFa) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 8.149999618530273 pEC50
Reference (Journal): Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.
Published in: J Biol Chem

Ligand: QRFP26 (26RFa) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity: 8.149999618530273 pEC50
Reference (Journal): Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity.
Published in: Proc Natl Acad Sci USA

Ligand: QRFP43 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.64 pEC50
Reference (Journal): A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
Published in: Proc Natl Acad Sci USA

Ligand: QRFP43 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
Published in: Proc Natl Acad Sci USA

Ligand: QRFP43 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
Published in: Proc Natl Acad Sci USA

Ligand: QRFP43 (43RFa) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity.
Published in: Proc Natl Acad Sci USA

Ligand: QRFP43 (43RFa) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pEC50
Reference (Journal): A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
Published in: Proc Natl Acad Sci USA

Ligand: QRFP43 (43RFa) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Recent advances in mammalian RFamide peptides: the discovery and functional analyses of PrRP, RFRPs and QRFP.
Published in: Peptides

Ligand: QRFP43 (43RFa) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pEC50
Reference (Journal): Screening β-Arrestin Recruitment for the Identification of Natural Ligands for Orphan G-Protein-Coupled Receptors.
Published in: J Biomol Screen

Ligand: QRFP43 (43RFa) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
Published in: Proc Natl Acad Sci USA

Ligand: QRFP43 (43RFa) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pIC50
Reference (Journal): A new peptidic ligand and its receptor regulating adrenal function in rats.
Published in: J Biol Chem

Ligand: [125I]26RFa (human) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat.
Published in: J Comp Neurol

Ligand: [125I]QRFP43 (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pKd
Reference (Journal): A new peptidic ligand and its receptor regulating adrenal function in rats.
Published in: J Biol Chem

Ligand: [125I]QRFP43 (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
Published in: Proc Natl Acad Sci USA

Ligand: [125I]QRFP43 (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  pKd
Reference (Journal): A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
Published in: Proc Natl Acad Sci USA