Target family: Lanosterol biosynthesis pathway (type: enzyme)
Target: diphosphomevalonate decarboxylase

Ligand: 2,2-difluoromevalonate 5-diphosphate (Synthetic organic)
Interaction type: Inhibitor
Action: Competitive
Ligand approved: no
Median affinity: 5.12 pIC50
Reference (Journal): Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase.
Published in: Bioorg Med Chem Lett

Ligand: 2-fluoromevalonate 5-diphosphate (Synthetic organic)
Interaction type: Inhibitor
Action: Irreversible inhibition
Ligand approved: no
Median affinity: 5.52 pKi
Reference (Journal): Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs.
Published in: Biochim Biophys Acta

Ligand: 6-fluoromevalonate 5-diphosphate (Synthetic organic)
Interaction type: Inhibitor
Action: Competitive
Ligand approved: no
Median affinity: 7.21 pKi
Reference (Journal): Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure.
Published in: Arch Biochem Biophys

Ligand: 6-fluoromevalonate pyrophosphate (Synthetic organic)
Interaction type: Inhibitor
Action: Competitive
Ligand approved: no
Primary target: no
Median affinity: 7.429999828338623 pKi
Reference (Journal): Inhibition of mevalonate 5-pyrophosphate decarboxylase by a proline-containing transition state analog.
Published in: Bioorg Med Chem Lett

Ligand: analog 3 [Vlattas et al., 1996] (Synthetic organic)
Interaction type: Inhibitor
Action: Competitive
Ligand approved: no
Primary target: no
Median affinity: 6.119999885559082 pKi
Reference (Journal): Inhibition of mevalonate 5-pyrophosphate decarboxylase by a proline-containing transition state analog.
Published in: Bioorg Med Chem Lett

Ligand: compound 18 [PMID: 17888661] (Synthetic organic)
Interaction type: Inhibitor
Action: Competitive
Ligand approved: no
Median affinity: 4.1 pIC50
Reference (Journal): Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase.
Published in: Bioorg Med Chem Lett

Ligand: compound 19 [PMID: 17888661] (Synthetic organic)
Interaction type: Inhibitor
Action: Competitive
Ligand approved: no
Median affinity: 3.92 pIC50
Reference (Journal): Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase.
Published in: Bioorg Med Chem Lett

Ligand: diphosphoglycolyl proline (Synthetic organic)
Interaction type: Inhibitor
Action: Competitive
Ligand approved: no
Median affinity: 8.64 pKi
Reference (Journal): Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure.
Published in: Arch Biochem Biophys

Ligand: geranyl diphosphate (Metabolite)
Interaction type: Inhibitor
Action: Feedback inhibition
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs.
Published in: Biochim Biophys Acta

Ligand: geranyl diphosphate (Metabolite)
Interaction type: Inhibitor
Action: Feedback inhibition
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase.
Published in: Org Lett

Ligand: P'-geranyl 2-fluoromevalonate 5-diphosphate (Synthetic organic)
Interaction type: Inhibitor
Action: Competitive
Ligand approved: no
Median affinity: 5.38 pKi
Reference (Journal): Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure.
Published in: Arch Biochem Biophys

Ligand: P'-geranyl 2-fluoromevalonate 5-diphosphate (Synthetic organic)
Interaction type: Inhibitor
Action: Competitive
Ligand approved: no
Median affinity: 5.34 pIC50
Reference (Journal): Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase.
Published in: Bioorg Med Chem Lett

Ligand: P'-geranyl 3,5,7-trihydroxy-3-methylheptanate 7-diphosphate (Synthetic organic)
Interaction type: Inhibitor
Action: Competitive
Ligand approved: no
Median affinity: 5.59 pIC50
Reference (Journal): Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase.
Published in: Org Lett

Ligand: P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate (Synthetic organic)
Interaction type: Inhibitor
Action: Competitive
Ligand approved: no
Median affinity: 5.7 pIC50
Reference (Journal): Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase.
Published in: Org Lett

Ligand: P'-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphate (Synthetic organic)
Interaction type: Inhibitor
Action: Competitive
Ligand approved: no
Median affinity: 5.19 pKi
Reference (Journal): Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase.
Published in: Org Lett