Target family: Glucagon receptor family (type: gpcr)
Target: GHRH receptor

Ligand: JV-1-43 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.4 pKi
Reference (Journal): Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities.
Published in: Proc Natl Acad Sci USA

Ligand: JV-1-62 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.2 pKi
Reference (Journal): Increased activity of antagonists of growth hormone-releasing hormone substituted at positions 8, 9, and 10.
Published in: Proc Natl Acad Sci USA

Ligand: JV-1-63 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.2 pKi
Reference (Journal): Increased activity of antagonists of growth hormone-releasing hormone substituted at positions 8, 9, and 10.
Published in: Proc Natl Acad Sci USA

Ligand: MZ-4-169 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.4 pKi
Reference (Journal): Synthesis and biological activities of highly potent antagonists of growth hormone-releasing hormone.
Published in: Proc Natl Acad Sci USA

Ligand: MZ-4-181 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.3 pKi
Reference (Journal): Synthesis and biological activities of highly potent antagonists of growth hormone-releasing hormone.
Published in: Proc Natl Acad Sci USA

Ligand: MZ-4-243 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.4 pKi
Reference (Journal): Synthesis and biological activities of highly potent antagonists of growth hormone-releasing hormone.
Published in: Proc Natl Acad Sci USA

Ligand: MZ-4-71 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 9.9 pKi
Reference (Journal): Synthesis and biological activities of highly potent antagonists of growth hormone-releasing hormone.
Published in: Proc Natl Acad Sci USA

Ligand: MZ-4-71 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 9.9 pKi
Reference (Journal): Synthesis and in vitro evaluation of new potent antagonists of growth hormone-releasing hormone (GH-RH).
Published in: Peptides

Ligand: MZ-5-156 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.2 pKi
Reference (Journal): Synthesis and in vitro evaluation of new potent antagonists of growth hormone-releasing hormone (GH-RH).
Published in: Peptides

Ligand: MZ-5-192 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.2 pIC50
Reference (Journal): Synthesis and in vitro evaluation of new potent antagonists of growth hormone-releasing hormone (GH-RH).
Published in: Peptides

Ligand: MZ-5-78 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.2 pIC50
Reference (Journal): Synthesis and in vitro evaluation of new potent antagonists of growth hormone-releasing hormone (GH-RH).
Published in: Peptides

Ligand: MZ-6-55 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.2 pKi
Reference (Journal): Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities.
Published in: Proc Natl Acad Sci USA

Ligand: [125I]GHRH (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.6 pKd
Reference (Journal): Characterization of a growth hormone-releasing hormone binding site in the rat renal medulla.
Published in: Peptides

Ligand: [Ac-Tyr1, D-Arg2]GHRH-(1-29)-NH2 (human) (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Synthesis and biological activities of highly potent antagonists of growth hormone-releasing hormone.
Published in: Proc Natl Acad Sci USA

Ligand: [Ac-Tyr1, D-Arg2]GHRH-(1-29)-NH2 (human) (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Increased activity of antagonists of growth hormone-releasing hormone substituted at positions 8, 9, and 10.
Published in: Proc Natl Acad Sci USA

Ligand: [Ac-Tyr1, D-Arg2]GHRH-(1-29)-NH2 (human) (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Synthesis and in vitro evaluation of new potent antagonists of growth hormone-releasing hormone (GH-RH).
Published in: Peptides

Ligand: [Ac-Tyr1, D-Arg2]GHRH-(1-29)-NH2 (human) (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities.
Published in: Proc Natl Acad Sci USA

Ligand: BIM28011 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Structural simplification of potent growth hormone-releasing hormone analogs: implications for other members of the VIP/GHRH/PACAP family.
Published in: Ann N Y Acad Sci

Ligand: GHRH (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -

Ligand: GHRH-(1-29)-NH2 (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.2 pIC50
Reference (Journal): Affinity of human growth hormone-releasing factor (1-29)NH2 analogues for GRF binding sites in rat adenopituitary.
Published in: J Med Chem

Ligand: GHRH-(1-29)-NH2 (rat) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.1 pIC50
Reference (Journal): Affinity of human growth hormone-releasing factor (1-29)NH2 analogues for GRF binding sites in rat adenopituitary.
Published in: J Med Chem

Ligand: GHRH-(1-29)-OH (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8 pIC50
Reference (Journal): Affinity of human growth hormone-releasing factor (1-29)NH2 analogues for GRF binding sites in rat adenopituitary.
Published in: J Med Chem

Ligand: JI-38 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Synthesis of new potent agonistic analogs of growth hormone-releasing hormone (GHRH) and evaluation of their endocrine and cardiac activities.
Published in: Peptides

Ligand: JI-38 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Cardioprotective effects of growth hormone-releasing hormone agonist after myocardial infarction.
Published in: Proc Natl Acad Sci USA

Ligand: JMR-132 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 9.850000381469727 pIC50
Reference (Journal): Potentiation of mammary cancer inhibition by combination of antagonists of growth hormone-releasing hormone with docetaxel.
Published in: Proc Natl Acad Sci USA

Ligand: JV-1-10 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.3 pKi
Reference (Journal): Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities.
Published in: Proc Natl Acad Sci USA

Ligand: JV-1-36 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pKi
Reference (Journal): Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities.
Published in: Proc Natl Acad Sci USA

Ligand: JV-1-36 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pKi
Reference (Journal): Antagonistic Analogs of Growth Hormone-releasing Hormone: New Potential Antitumor Agents.
Published in: Trends Endocrinol Metab

Ligand: JV-1-36 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pKi
Reference (Journal): Increased activity of antagonists of growth hormone-releasing hormone substituted at positions 8, 9, and 10.
Published in: Proc Natl Acad Sci USA

Ligand: JV-1-37 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.4 pKi
Reference (Journal): Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities.
Published in: Proc Natl Acad Sci USA

Ligand: JV-1-38 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 10.100000381469727 pKi
Reference (Journal): Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities.
Published in: Proc Natl Acad Sci USA

Ligand: JV-1-38 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 10.100000381469727 pKi
Reference (Journal): Increased activity of antagonists of growth hormone-releasing hormone substituted at positions 8, 9, and 10.
Published in: Proc Natl Acad Sci USA

Ligand: JV-1-38 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 10.100000381469727 pKi
Reference (Journal): Antagonistic Analogs of Growth Hormone-releasing Hormone: New Potential Antitumor Agents.
Published in: Trends Endocrinol Metab

Ligand: JV-1-39 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.1 pKi
Reference (Journal): Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities.
Published in: Proc Natl Acad Sci USA

Ligand: JV-1-40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.4 pKi
Reference (Journal): Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities.
Published in: Proc Natl Acad Sci USA

Ligand: JV-1-41 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.4 pKi
Reference (Journal): Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities.
Published in: Proc Natl Acad Sci USA

Ligand: JV-1-42 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.4 pKi
Reference (Journal): Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities.
Published in: Proc Natl Acad Sci USA