Target family: Delta subfamily (type: enzyme)
Target: protein kinase C alpha

Ligand: 10-Me-Aplog-1 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 8.329999923706055 pKi
Reference (Journal): Structure-activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity.
Published in: J Med Chem

Ligand: 7-hydroxystaurosporine (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 7.539999961853027 pIC50
Reference (Journal): Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue.
Published in: Mol Pharmacol

Ligand: balanol (Natural product)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.519999980926514 pIC50
Reference (Journal): Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A.
Published in: J Med Chem

Ligand: darovasertib (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 8.720000267028809 pIC50
Reference (Patent): Protein kinase C inhibitors and methods of their use

Ligand: enzastaurin (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.099999904632568 pIC50
Reference (Journal): Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta.
Published in: Bioorg Med Chem Lett

Ligand: GF109203X (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 7.699999809265137 pIC50
Reference (Journal): The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.
Published in: J Biol Chem

Ligand: Gö 6976 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8.640000343322754 pIC50
Reference (Journal): Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.
Published in: J Biol Chem

Ligand: Gö 6983 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8.149999618530273 pIC50
Reference (Journal): Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes.
Published in: FEBS Lett

Ligand: ingenol mebutate (Natural product)
Interaction type: Activator
Action: Activation
Ligand approved: yes
Approval source: FDA & EMA (2012)
Primary target: no
Median affinity: 9.520000457763672 pKi
Reference (Journal): Characterization of the interaction of ingenol 3-angelate with protein kinase C.
Published in: Cancer Res

Ligand: RasGRP activator 1 (Synthetic organic)
Interaction type: Activator
Action: Binding
Ligand approved: no
Primary target: no
Median affinity: 7.789999961853027 pKi
Reference (Journal): Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.
Published in: Bioorg Med Chem

Ligand: Ro-32-0432 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity:  pIC50
Reference (Journal): Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation.
Published in: J Pharmacol Exp Ther

Ligand: Ro-32-0432 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity:  pIC50
Reference (Journal): Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.
Published in: Biochem J

Ligand: ruboxistaurin (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.440000057220459 pIC50
Reference (Journal): Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors.
Published in: Bioorg Med Chem Lett

Ligand: sotrastaurin (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: yes
Median affinity: 8.680000305175781 pIC50
Reference (Journal): Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.
Published in: J Med Chem

Ligand: Teleocidin B4 (Natural product)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Teleocidin B-4, a PKC Activator, Upregulates Hypoxia-Inducible Factor 1 (HIF-1) Activity by Promoting the Accumulation of HIF-1α Protein via the PKCα/mTORC Signaling Pathway
Published in: J Nat Prod