Target family: Neuropeptide Y receptors (type: gpcr)
Target: Y<sub>4</sub> receptor

Ligand: tert-butylphenoxycyclohexanol (Synthetic organic)
Interaction type: Allosteric modulator
Action: Positive
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Identification and Characterization of the First Selective Y<sub>4</sub> Receptor Positive Allosteric Modulator.
Published in: J Med Chem

Ligand: (S)-VU0637120 (Synthetic organic)
Interaction type: Allosteric modulator
Action: Negative
Ligand approved: no
Primary target: no
Median affinity: 5.570000171661377 pIC50
Reference (Journal): Highly Selective Y<sub>4</sub> Receptor Antagonist Binds in an Allosteric Binding Pocket.
Published in: J Med Chem

Ligand: [125I]PYY (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.8 pKd
Reference (Journal): Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.
Published in: J Biol Chem

Ligand: [125I]PP (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  -

Ligand: [125I]GR231118 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.6 pKd
Reference (Journal): [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors.
Published in: Br J Pharmacol

Ligand: PYY-(3-36) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.2 pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: PYY-(3-36) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.6 pKi
Reference (Journal): [125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Published in: Peptides

Ligand: PYY-(13-36) (mouse, rat, pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.5 pKi
Reference (Journal): [125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Published in: Peptides

Ligand: PYY-(13-36) (mouse, rat, pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.2 pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: [Pro34]PYY (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.9 pKi
Reference (Journal): Y(4) receptors mediate the inhibitory responses of pancreatic polypeptide in human and mouse colon mucosa.
Published in: J Pharmacol Exp Ther

Ligand: [Pro34]PYY (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.5 pKi
Reference (Journal): Y(4) receptors mediate the inhibitory responses of pancreatic polypeptide in human and mouse colon mucosa.
Published in: J Pharmacol Exp Ther

Ligand: [Pro34]PYY (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.6 pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: PP-(2-36) (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 10.4 pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: PP-(20-36) (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.1 pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: PP-(13-36) (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9 pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: peptide YY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.4 pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: peptide YY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.8 pKi
Reference (Journal): Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.
Published in: J Biol Chem

Ligand: peptide YY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): [125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Published in: Peptides

Ligand: peptide YY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family.
Published in: FEBS Lett

Ligand: peptide YY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.3 pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: peptide YY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Y(4) receptors mediate the inhibitory responses of pancreatic polypeptide in human and mouse colon mucosa.
Published in: J Pharmacol Exp Ther

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.
Published in: J Biol Chem

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor.
Published in: Proc Natl Acad Sci USA

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 10.6 pKi
Reference (Journal): Y(4) receptors mediate the inhibitory responses of pancreatic polypeptide in human and mouse colon mucosa.
Published in: J Pharmacol Exp Ther

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.
Published in: J Biol Chem

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 10 pKi
Reference (Journal): Y(4) receptors mediate the inhibitory responses of pancreatic polypeptide in human and mouse colon mucosa.
Published in: J Pharmacol Exp Ther

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 10.7 pKi
Reference (Journal): Y(4) receptors mediate the inhibitory responses of pancreatic polypeptide in human and mouse colon mucosa.
Published in: J Pharmacol Exp Ther

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): [125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Published in: Peptides

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): [125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Published in: Peptides

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): [125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Published in: Peptides

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.6 pIC50
Reference (Journal): Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.
Published in: Proc Natl Acad Sci USA

Ligand: pancreatic polypeptide (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.
Published in: Proc Natl Acad Sci USA

Ligand: NPY-(3-36) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.7 pKi
Reference (Journal): [125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Published in: Peptides

Ligand: NPY-(2-36) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.4 pKi
Reference (Journal): Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.
Published in: J Biol Chem

Ligand: NPY-(2-36) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.9 pKi
Reference (Journal): [125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Published in: Peptides

Ligand: NPY-(2-36) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family.
Published in: FEBS Lett

Ligand: NPY-(13-36) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: NPY-(13-36) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.9 pKi
Reference (Journal): Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.
Published in: J Biol Chem

Ligand: NPY-(13-36) (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): [125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Published in: Peptides

Ligand: NPY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.7 pKi
Reference (Journal): [125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Published in: Peptides

Ligand: neuropeptide Y (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): [125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Published in: Peptides

Ligand: neuropeptide Y (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.4 pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: neuropeptide Y (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: neuropeptide Y (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8 pKi
Reference (Journal): Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.
Published in: J Biol Chem

Ligand: [Leu31,Pro34]PYY (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8 pIC50
Reference (Journal): [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors.
Published in: Br J Pharmacol

Ligand: [Leu31,Pro34]PYY (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 10.2 pKi
Reference (Journal): [125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Published in: Peptides

Ligand: [Leu31,Pro34]NPY (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.4 pIC50
Reference (Journal): [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors.
Published in: Br J Pharmacol

Ligand: [Leu31,Pro34]NPY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): [125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Published in: Peptides

Ligand: [Leu31,Pro34]NPY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family.
Published in: FEBS Lett

Ligand: [Leu31,Pro34]NPY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: [Leu31,Pro34]NPY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor.
Published in: Proc Natl Acad Sci USA

Ligand: [Leu31,Pro34]NPY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.7 pKi
Reference (Journal): Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.
Published in: J Biol Chem

Ligand: [Leu31,Pro34]NPY (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.3 pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: [Ile31,Gln34]PP (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.2 pKi
Reference (Journal): A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.
Published in: Peptides

Ligand: GR231118 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.8 pKi
Reference (Journal): Y(4) receptors mediate the inhibitory responses of pancreatic polypeptide in human and mouse colon mucosa.
Published in: J Pharmacol Exp Ther

Ligand: GR231118 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.8 pKi
Reference (Journal): Y(4) receptors mediate the inhibitory responses of pancreatic polypeptide in human and mouse colon mucosa.
Published in: J Pharmacol Exp Ther

Ligand: GR231118 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 9.5 pIC50
Reference (Journal): [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors.
Published in: Br J Pharmacol

Ligand: GR231118 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 10.8 pKi
Reference (Journal): [125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors.
Published in: Peptides

Ligand: [Ala31,Aib32]NPY (pig) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6 pIC50
Reference (Journal): Ala31-Aib32: identification of the key motif for high affinity and selectivity of neuropeptide Y at the Y5-receptor.
Published in: Biochemistry