Target family: Chemokine receptors (type: gpcr)
Target: CCR8

Ligand: CCL1 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8.
Published in: Mol Pharmacol

Ligand: CCL1 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Expression and regulation of chemokine receptors in human natural killer cells.
Published in: Blood

Ligand: CCL1 (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines.
Published in: J Biol Chem

Ligand: CCL8 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -

Ligand: CCL8 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -

Ligand: [125I]CCL1 (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKd
Reference (Journal): Expression and regulation of chemokine receptors in human natural killer cells.
Published in: Blood

Ligand: [125I]CCL1 (human) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKd
Reference (Journal): Identification of CCR8, the receptor for the human CC chemokine I-309.
Published in: J Biol Chem

Ligand: [125I]CCL1 (mouse) (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.7 pKd
Reference (Journal): Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3.
Published in: J Immunol

Ligand: vMCC-I (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 9.40999984741211 pIC50
Reference (Journal): HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines.
Published in: J Biol Chem

Ligand: vMIP-I (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines.
Published in: J Biol Chem

Ligand: vMIP-I (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pIC50
Reference (Journal): Expression and regulation of chemokine receptors in human natural killer cells.
Published in: Blood

Ligand: vMIP-II (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 8.100000381469727 pIC50
Reference (Journal): HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines.
Published in: J Biol Chem

Ligand: ZK 756326 (Synthetic organic)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 5.7 pIC50
Reference (Journal): Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8.
Published in: Mol Pharmacol