Target family: Inwardly rectifying potassium channels (K<sub>IR</sub>) (type: vgic)
Target: K<sub>ir</sub>6.2

Ligand: tolbutamide (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: yes
Approval source: FDA (1979)
Primary target: no
Median affinity:  -
Reference (Journal): A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel.
Published in: J Biol Chem

Ligand: tolbutamide (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: yes
Approval source: FDA (1979)
Primary target: no
Median affinity: 4.5 pIC50
Reference (Journal): Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.
Published in: Science

Ligand: tolbutamide (Synthetic organic)
Interaction type: Inhibitor
Action: None
Ligand approved: yes
Approval source: FDA (1979)
Primary target: yes
Median affinity:  -

Ligand: pinacidil (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: yes
Approval source: FDA (1989)
Median affinity:  -
Reference (Journal): A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels.
Published in: Neuron

Ligand: pinacidil (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: yes
Approval source: FDA (1989)
Median affinity:  -
Reference (Journal): A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel.
Published in: J Biol Chem

Ligand: nicorandil (Synthetic organic)
Interaction type: Activator
Action: None
Ligand approved: yes
Approval source: UK (2009)
Primary target: no
Median affinity:  -

Ligand: minoxidil (Synthetic organic)
Interaction type: Activator
Action: None
Ligand approved: yes
Approval source: FDA (1979)
Primary target: no
Median affinity:  -

Ligand: glibenclamide (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: yes
Approval source: FDA (as glyburide, 1984), EMA (2018)
Median affinity:  -
Reference (Journal): A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel.
Published in: J Biol Chem

Ligand: glibenclamide (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: yes
Approval source: FDA (as glyburide, 1984), EMA (2018)
Median affinity: 5.7 pIC50
Reference (Journal): Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.
Published in: Science

Ligand: glibenclamide (Synthetic organic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: yes
Approval source: FDA (as glyburide, 1984), EMA (2018)
Median affinity: 5.7 pIC50
Reference (Journal): A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels.
Published in: Neuron

Ligand: glibenclamide (Synthetic organic)
Interaction type: Inhibitor
Action: None
Ligand approved: yes
Approval source: FDA (as glyburide, 1984), EMA (2018)
Primary target: yes
Median affinity:  -

Ligand: diazoxide (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: yes
Approval source: FDA (1973)
Primary target: no
Median affinity: 4.199999809265137 pEC50
Reference (Journal): Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.
Published in: Science

Ligand: diazoxide (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: yes
Approval source: FDA (1973)
Primary target: no
Median affinity:  -
Reference (Journal): A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel.
Published in: J Biol Chem

Ligand: cromakalim (Synthetic organic)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels.
Published in: Neuron

Ligand: ATP (Metabolite)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  -
Reference (Journal): A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels.
Published in: Neuron

Ligand: ATP (Metabolite)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  -
Reference (Journal): Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.
Published in: Science