Target family: Galanin receptors (type: gpcr)
Target: GAL<sub>3</sub> receptor

Ligand: alarin (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pIC50
Reference (Journal): Alarin stimulates food intake and gonadotrophin release in male rats.
Published in: Br J Pharmacol

Ligand: [Ala6, D-Trp8]galanin-(1-15)-ol (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 7.75 pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.08 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: C7 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.08 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: (D-Thr6, D-Trp8,9)galanin(1-15)ol (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.16 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.12 pIC50
Reference (Journal): Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.
Published in: J Neurochem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): A novel GalR2-specific peptide agonist.
Published in: Neuropeptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.28 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.92 pIC50
Reference (Journal): Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.
Published in: J Neurochem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.14 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.01 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 7.16 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 8.01 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity: 6.96 pIC50
Reference (Journal): Alarin stimulates food intake and gonadotrophin release in male rats.
Published in: Br J Pharmacol

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Binding of chimeric peptides M617 and M871 to galanin receptor type 3 reveals characteristics of galanin receptor-ligand interaction.
Published in: Int J Pept Res

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation.
Published in: FEBS Lett

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Partial agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Galanin receptor ligands.
Published in: Neuropeptides

Ligand: galanin (Peptide)
Interaction type: Agonist
Action: Full agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Novel galanin receptor subtype specific ligands in feeding regulation.
Published in: Neurochem Int

Ligand: galanin(10-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.5 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.5 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin(1-16) (rat/mouse/pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation.
Published in: FEBS Lett

Ligand: galanin(1-19) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.2 pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: galanin(2-11) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.7 pKi
Reference (Journal): A novel GalR2-specific peptide agonist.
Published in: Neuropeptides

Ligand: galanin(2-11) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.57 pKi
Reference (Journal): Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes.
Published in: Neuropeptides

Ligand: galanin(2-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.22 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(2-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.9 pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: galanin(2-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.9 pKi
Reference (Journal): The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation.
Published in: FEBS Lett

Ligand: galanin(3-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin(3-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(3-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin(3-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: galanin(3-29) (rat/mouse) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation.
Published in: FEBS Lett

Ligand: galanin(7-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.45 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin(7-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.52 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin(7-29) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.45 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(D-Trp2) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin(D-Trp2) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: galanin(D-Trp2) (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: galanin-like peptide (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8 pIC50
Reference (Journal): Pharmacological and functional characterization of galanin-like peptide fragments as potent galanin receptor agonists.
Published in: Neuropeptides

Ligand: galanin-like peptide (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 8.82 pIC50
Reference (Journal): Alarin stimulates food intake and gonadotrophin release in male rats.
Published in: Br J Pharmacol

Ligand: GalR3ant (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Galanin receptor ligands.
Published in: Neuropeptides

Ligand: GalR3ant (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Patent): 3-Imino-2-indolones for the treatment of depression and/or anxiety.

Ligand: J18 (galanin analogue) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.95 pKi
Reference (Journal): Novel systemically active galanin receptor 2 ligands in depression-like behavior.
Published in: J Neurochem

Ligand: J20 (galanin analogue) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.89 pKi
Reference (Journal): Novel systemically active galanin receptor 2 ligands in depression-like behavior.
Published in: J Neurochem

Ligand: M1145 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.3 pKi
Reference (Journal): A novel GalR2-specific peptide agonist.
Published in: Neuropeptides

Ligand: M1151 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.06 pKi
Reference (Journal): Novel galanin receptor subtype specific ligands in feeding regulation.
Published in: Neurochem Int

Ligand: M1152 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.18 pKi
Reference (Journal): Novel galanin receptor subtype specific ligands in feeding regulation.
Published in: Neurochem Int

Ligand: M1153 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 6.64 pKi
Reference (Journal): Novel galanin receptor subtype specific ligands in feeding regulation.
Published in: Neurochem Int

Ligand: M1160 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 5 pKd
Reference (Journal): Novel galanin receptor subtype specific ligand in depression like behavior.
Published in: Neurochem Res

Ligand: M1160 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 5 pKi
Reference (Journal): Novel galanin receptor subtype specific ligand in depression like behavior.
Published in: Neurochem Res

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 7.4 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 7.4 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: M15 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Galanin receptor ligands.
Published in: Neuropeptides

Ligand: M32 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.22 pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: M32 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.22 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: M32 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 8.91 pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: M35 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: M35 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: M35 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: M35 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: M35 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Galanin receptor ligands.
Published in: Neuropeptides

Ligand: M35 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Binding of chimeric peptides M617 and M871 to galanin receptor type 3 reveals characteristics of galanin receptor-ligand interaction.
Published in: Int J Pept Res

Ligand: M40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Binding of chimeric peptides M617 and M871 to galanin receptor type 3 reveals characteristics of galanin receptor-ligand interaction.
Published in: Int J Pept Res

Ligand: M40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Galanin receptor ligands.
Published in: Neuropeptides

Ligand: M40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: M40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: M40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: M40 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: M617 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity: 7.31 pKi
Reference (Journal): Binding of chimeric peptides M617 and M871 to galanin receptor type 3 reveals characteristics of galanin receptor-ligand interaction.
Published in: Int J Pept Res

Ligand: M871 (Peptide)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Median affinity: 5 pKi
Reference (Journal): Binding of chimeric peptides M617 and M871 to galanin receptor type 3 reveals characteristics of galanin receptor-ligand interaction.
Published in: Int J Pept Res

Ligand: SNAP 37889 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pKi
Reference (Journal): 3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists.
Published in: J Med Chem

Ligand: SNAP 37889 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pKi
Reference (Journal): Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility.
Published in: Bioorg Med Chem Lett

Ligand: SNAP 37889 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pKi
Reference (Journal): Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299.
Published in: Proc Natl Acad Sci USA

Ligand: SNAP 398299 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 8.270000457763672 pKi
Reference (Journal): Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility.
Published in: Bioorg Med Chem Lett

Ligand: SNAP 398299 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 8.270000457763672 pKi
Reference (Journal): Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299.
Published in: Proc Natl Acad Sci USA

Ligand: SNAP 398299 (Synthetic organic)
Interaction type: Antagonist
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 8.270000457763672 pKi
Reference (Journal): 3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists.
Published in: J Med Chem

Ligand: spexin-1 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 6.199999809265137 pEC50
Reference (Journal): Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.
Published in: Endocrinology

Ligand: [125I]spexin-1 (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.
Published in: Endocrinology

Ligand: [125I][Tyr26]galanin (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 8.649999618530273 pKd
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem

Ligand: [125I][Tyr26]galanin (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Primary target: no
Median affinity: 8.649999618530273 pKd
Reference (Journal): Cloning and characterization of the human galanin GALR2 receptor.
Published in: Peptides

Ligand: [125I][Tyr26]galanin (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKd
Reference (Journal): Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes.
Published in: J Biol Chem

Ligand: [125I][Tyr26]galanin (pig) (Peptide)
Interaction type: Agonist
Action: Agonist
Ligand approved: no
Median affinity:  pKd
Reference (Journal): Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Published in: J Biol Chem