Target family: Transient Receptor Potential channels (TRP) (type: vgic)
Target: TRPML1

Ligand: estradiol 3-methyl ether (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.21999979019165 pIC50
Reference (Journal): Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors.
Published in: Sci Rep

Ligand: estradiol 3-methyl ether (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.21999979019165 pIC50
Reference (Journal): Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors.
Published in: Sci Rep

Ligand: estradiol 3-methyl ether (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6.659999847412109 pIC50
Reference (Journal): Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors.
Published in: Sci Rep

Ligand: MK6-83 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 7 pEC50
Reference (Journal): A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.
Published in: Nat Commun

Ligand: MK6-83 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 6.960000038146973 pEC50
Reference (Journal): A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.
Published in: Nat Commun

Ligand: ML1-SA1 (Synthetic organic)
Interaction type: Activator
Action: None
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice.
Published in: Nat Commun

Ligand: ML SA1 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 7.300000190734863 pEC50
Reference (Journal): Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release.
Published in: Nat Commun

Ligand: ML-SA5 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 5.300000190734863 pEC50
Reference (Journal): Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models.
Published in: Sci Adv

Ligand: phosphatidyl (3,5) inositol bisphosphate (Metabolite)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 7.320000171661377 pEC50
Reference (Journal): PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome.
Published in: Nat Commun

Ligand: PRU-10 (Synthetic organic)
Interaction type: Inhibitor
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.389999866485596 pIC50
Reference (Journal): Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors.
Published in: Sci Rep

Ligand: PRU-12 (Synthetic organic)
Interaction type: Channel blocker
Action: Inhibition
Ligand approved: no
Primary target: no
Median affinity: 6.550000190734863 pIC50
Reference (Journal): Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors.
Published in: Sci Rep

Ligand: SF-22 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 6.300000190734863 pEC50
Reference (Journal): A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.
Published in: Nat Commun

Ligand: SF-51 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 4.5 pEC50
Reference (Journal): Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release.
Published in: Nat Commun