Target family: Voltage-gated potassium channels (K<sub>v</sub>) (type: vgic)
Target: K<SUB>v</SUB>7.4

Ligand: bepridil (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: yes
Approval source: FDA (1990)
Median affinity: 5 pIC50
Reference (Journal): KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology.
Published in: Am J Physiol, Cell Physiol

Ligand: flindokalner (Synthetic organic)
Interaction type: Activator
Action: None
Ligand approved: no
Median affinity: 5 pEC50
Reference (Journal): KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology.
Published in: Am J Physiol, Cell Physiol

Ligand: linopirdine (Synthetic organic)
Interaction type: Inhibitor
Action: None
Ligand approved: no
Primary target: no
Median affinity: 4.900000095367432 pIC50
Reference (Journal): KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology.
Published in: Am J Physiol, Cell Physiol

Ligand: ML213 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 6.300000190734863 pEC50
Reference (Journal): Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener.
Published in: ACS Chem Neurosci

Ligand: NC00075159 (Synthetic organic)
Interaction type: Activator
Action: Activation
Ligand approved: no
Primary target: no
Median affinity: 5 pEC50
Reference (Journal): Identification of novel KCNQ4 openers by a high-throughput fluorescence-based thallium flux assay.
Published in: Anal Biochem

Ligand: PIP2 (Metabolite)
Interaction type: Activator
Action: None
Ligand approved: no
Median affinity: 3.7 pEC50
Reference (Journal): Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate.
Published in: J Neurosci

Ligand: retigabine (Synthetic organic)
Interaction type: Activator
Action: None
Ligand approved: yes
Approval source: FDA and EMA (2011)
Primary target: yes
Median affinity: 5.199999809265137 pEC50
Reference (Journal): Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine.
Published in: J Neurosci

Ligand: retigabine derivative 10g (Synthetic organic)
Interaction type: Activator
Action: None
Ligand approved: no
Primary target: no
Median affinity: 6 pEC50
Reference (Journal): Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity.
Published in: ACS Med Chem Lett

Ligand: (S)-N-[1-(3-morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamide (Synthetic organic)
Interaction type: Activator
Action: None
Ligand approved: no
Primary target: no
Median affinity: 5 pIC50
Reference (Journal): The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels.
Published in: Neuropharmacology

Ligand: tetraethylammonium (Synthetic organic)
Interaction type: Channel blocker
Action: None
Ligand approved: no
Primary target: no
Median affinity: 1.2999999523162842 pIC50
Reference (Journal): Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.
Published in: J Biol Chem

Ligand: XE991 (Synthetic organic)
Interaction type: Inhibitor
Action: None
Ligand approved: no
Primary target: no
Median affinity: 5.300000190734863 pIC50
Reference (Journal): KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology.
Published in: Am J Physiol, Cell Physiol

Ligand: zinc pyrithione (Synthetic organic)
Interaction type: Activator
Action: None
Ligand approved: no
Median affinity: 5 pEC50
Reference (Journal): Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants.
Published in: Nat Chem Biol