Target family: Inwardly rectifying potassium channels (K<sub>IR</sub>) (type: vgic)
Target: K<sub>ir</sub>2.3

Ligand: putrescine (Metabolite)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  -
Reference (Journal): Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification.
Published in: Nature

Ligand: Mg2+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 5 pKd
Reference (Journal): Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification.
Published in: Nature

Ligand: H+ (Inorganic)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Effects of intra- and extracellular acidifications on single channel Kir2.3 currents.
Published in: J Physiol (Lond.)

Ligand: H+ (Inorganic)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Effects of intra- and extracellular acidifications on single channel Kir2.3 currents.
Published in: J Physiol (Lond.)

Ligand: H+ (Inorganic)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Gating of inward rectifier K+ channels by proton-mediated interactions of N- and C-terminal domains.
Published in: J Biol Chem

Ligand: H+ (Inorganic)
Interaction type: Gating inhibitor
Action: Antagonist
Ligand approved: no
Median affinity:  pKi
Reference (Journal): Identification and molecular localization of a pH-sensing domain for the inward rectifier potassium channel HIR.
Published in: Neuron

Ligand: Cs+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 4.960000038146973 pIC50
Reference (Journal): Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel.
Published in: FEBS Lett

Ligand: Cs+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 4.960000038146973 pIC50
Reference (Journal): Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain.
Published in: FEBS Lett

Ligand: Cs+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity:  pKi
Reference (Journal): Cloning and expression of a novel human brain inward rectifier potassium channel.
Published in: J Biol Chem

Ligand: Ba2+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 4.989999771118164 pIC50
Reference (Journal): Cloning and expression of a novel human brain inward rectifier potassium channel.
Published in: J Biol Chem

Ligand: Ba2+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 4.989999771118164 pIC50
Reference (Journal): Cloning a novel human brain inward rectifier potassium channel and its functional expression in Xenopus oocytes.
Published in: FEBS Lett

Ligand: Ba2+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Primary target: no
Median affinity: 4.989999771118164 pIC50
Reference (Journal): Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome.
Published in: Proc Natl Acad Sci USA

Ligand: Ba2+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Median affinity: 5.19 pIC50
Reference (Journal): Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel.
Published in: FEBS Lett

Ligand: Ba2+ (Inorganic)
Interaction type: Channel blocker
Action: Antagonist
Ligand approved: no
Median affinity: 5.19 pIC50
Reference (Journal): Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain.
Published in: FEBS Lett

Ligand: arachidonic acid (Metabolite)
Interaction type: Activator
Action: Agonist
Ligand approved: no
Median affinity: 6.35 pEC50
Reference (Journal): Direct activation of an inwardly rectifying potassium channel by arachidonic acid.
Published in: Mol Pharmacol