Clinical trial NCT03545503
Conditions: Intubation Complication
Keywords: Rapid Sequence Intubation Hemodynamics Etomidate Ketamine
Sponsor: South East Area Health Education Center, Wilmington, NC
Start date: 2018-01-01; Completion date: 2019-09-01
Enrollment: 428 participants; Allocation: RANDOMIZED; Intervention model: PARALLEL

Brief summary:
The purpose of this study is to compare the hemodynamic effects of ketamine v etomidate during rapid sequence intubation (RSI) in the pre-hospital and emergency department setting.

Detailed description:
This is a randomized prospective study evaluating the hemodynamic response in adult participants greater than or equal to 18 years of age undergoing RSI in the pre-hospital or emergency department setting. Hemodynamic response is the cardiology response of the circulatory system. The investigators will compare the drugs Ketamine and Etomidate in participants having RSI. Ketamine and Etomidate are immediately available for RSI in both settings as both are currently standards of care for RSI.

Research thus far demonstrates that both Etomidate and ketamine are safe and effective for RSI. Despite the reported safety of Ketamine, Etomidate usage continues to far surpass that of ketamine. Both Etomidate and Ketamine are FDA-approved for induction of anesthesia. They are both ideal drugs for intubation due to their pharmacokinetic properties including a quick onset of less than 60 seconds, a short duration of about 10 minutes, and the minimal effect they have on the cardiovascular system. The neutral effect on the cardiovascular system is particularly important in the acute and traumatic setting when patients are often hypotensive.

However, there are some differences and disadvantages in the two medications. Due to these factors and limited data to support Ketamine as an equal or superior alternative to Etomidate, it has been difficult to clearly recommend one agent over the other for RSI.

Data will be analyzed using SPSS with a p-value of less than 0.05 being considered significant. The PI will consider a 20% decrease in systolic BP from a participant baseline as significant, and will compare the incidence of post RSI hypotension between the two groups. Several a priori subgroups will be evaluated to include patients greater than 70 years of age, trauma participants requiring RSI, and those participants whose shock index is less than 0.9 versus those whose shock index is greater than 0.9.

To maintain 80% power with a probability of 0.05, 200 participants will be needed in each arm to detect at 25% difference in SBP (baseline to post drug administration effects)

Arms: arm 1: Etomidate will be dosed once at a standard of 0.3 mg/kg via IV Push arm 2: Ketamine will be dosed once at a standard 2 mg/kg via IV Push
Interventions: intervention 1: Etomidate intervention 2: Ketamine
Intervention descriptions: intervention 1: Etomidate will be administered as the sedative for RSI on even days intervention 2: Ketamine will be administered as the sedative for RSI on odd days

Protocol documents:
Prot_SAP_000.pdf: 
KeT RSI  
 
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KeT RSI: A randomized controlled trial to evaluate the hemodynamic effects of ketamine vs 
etomidate during rapid sequence intubation 
 
Principal Investigator: 
William F. Powers, IV, MD, FACS1 
 
 
 
 
910-667-9232 
 
 
 
 
william.powers@nhrmc.org  
 
Co-Principal Investigators: 
Tasha Martin, MD1 
 
 
 
 
985-951-9201 
 
 
 
 
tasha.martin@nhrmc.org  
 
 
 
 
 
Katie Taylor, PharmD2 
 
 
 
 
540-907-5166 
 
 
 
 
katie.taylor@nhrmc.org    
 
Co-Investigators: 
 
Lisa Hall Zimmerman, Pharm D, BCPS, BCNSP, BCCCP, FCCM2 
 
 
 
 
Kevin Collopy, BA, FP-C, NR-P, CMTE4 
 
 
 
 
Carrie Fales, MD3 
 
 
 
 
Wendy Housand4 
 
 
 
 
Steven Nakajima, PharmD, BCCCP2 
 
1 Department of General Surgery New Hanover Regional Medical Center 2131 S. 17th St. 
PO BOX 9000 Wilmington, NC 
2 Department of Pharmacy New Hanover Regional Medical Center 2131 S. 17th St. 
Wilmington, NC 28401 
3 Eastern Carolina Emergency Physicians 4402 Shipyard Boulevard Wilmington, NC 28403 
4 AirLink VitaLink New Hanover Regional Medical Center 2131 S. 17th St. Wilmington, NC 
28401 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 


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INTRODUCTION/BACKGROUND: 
Research thus far demonstrates that both etomidate and ketamine are safe and effective for 
rapid sequence intubation (RSI) in the emergent setting.  Despite the reported safety of 
ketamine, etomidate usage continues to far surpass that of ketamine. Both etomidate and 
ketamine are FDA-approved for induction of anesthesia. They are both ideal drugs for 
intubation due to their pharmacokinetic properties including a quick onset of less than 60 
seconds, a short duration of about 10 minutes, and the minimal effect they have on the 
cardiovascular system.   
 
The neutral effect on the cardiovascular system is particularly important in the acute and 
traumatic setting when patients are often hypotensive.  However, there are some differences 
and disadvantages in the two medications. Etomidate induces sedation by enhancing the effect 
of GABA, an inhibitory neurotransmitter, resulting in inhibition of excitatory stimuli. Etomidate 
lacks analgesic effects and has been shown to cause adrenal suppression, of which the long 
term significance still remains uncertain. Ketamine is a non-competitive N-methyl-D-aspartate 
(NMDA) antagonist and a weak opiod agonist which results in both amnestic and analgesic 
properties.  It is also a dissociative anesthetic and can cause profound hallucinations.  There are 
also historical reports of ketamine causing an elevation of ICP, although newer research has not 
shown that effect.  Due to all of these factors and limited data to support ketamine as an equal 
or superior alternative to etomidate, it has been difficult to clearly recommend one agent over 
the other for RSI.  
 
Previous literature has evaluated the hemodynamic effects of etomidate and ketamine during 
RSI but these studies have been retrospective in nature.    
 
A 2013 retrospective study by Price et al. did not find a significant difference between ketamine 
and etomidate in hemodynamics at any of the five post-intubation vital sign assessments.   We 
recently conducted a retrospective comparative study on the hemodynamic effects of the two 
medications in the pre-hospital setting at New Hanover Regional Medical Center.  There were 
more patients in the etomidate group to experience a decrease in SBP from pre-RSI to 15 
minutes post-RSI, although the difference was not significant.  We also discovered a lower SBP 
trend post-RSI with etomidate among the trauma and elderly population.  This study was 
limited by the number of patients that received ketamine and was therefore underpowered.   
 
A 2017, retrospective study was published with 968 adult trauma patients undergoing RSI in the 
ED with either etomidate or ketamine and results did not reveal a difference in patient-
centered outcomes between the two drugs including hospital mortality, ICU-free days, 
ventilator-free days, vasopressor-free days, and transfusion requirements.   
 
A prospective, randomized trial is needed to determine the superiority of one induction agent 
over another during this life saving measure. 
 
 
 


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AIM(S) OF STUDY: 
The aim of this study is to investigate the hemodynamic effects of ketamine and etomidate in 
the setting of rapid sequence intubation. 
 
OBJECTIVES: 
The objective of this study is to determine if ketamine or etomidate has a better hemodynamic 
profile in patients undergoing rapid sequence intubation. 
 
HYPOTHESIS: 
Primary Hypothesis: 
Compared to etomidate, ketamine will show an improved hemodynamic profile in patients 
undergoing rapid sequence intubation. 
 
STUDY DESIGN: 
This study will be a prospective randomized controlled trial evaluating the hemodynamic 
response in adult patients (greater than or equal to 18 years of age) undergoing rapid sequence 
intubation (RSI).   
 
STUDY SETTING: 
This study will be a single-center study to include pre-hospital RSI performed by New Hanover 
Regional Medical Centers (NHRMC) emergency transport service providers as well as 
emergency medical physicians performing RSI at the NHRMC emergency department located 
on the main hospital campus. 
 
STUDY POPULATION: 
Adult patients age 18 and greater who are not pregnant and require rapid sequence intubation 
will be part of the study population.  Patients may require rapid sequence intubation to secure 
his or her airway for a myriad of reasons to include trauma, impending respiratory failure, 
septic shock.  These patients often have labile hemodynamics in the time period surrounding 
intubation and the drugs used may influence this hemodynamic response.   
 
This study is projected to treat approximately 400 subjects.  Our goal is to have 200 patients in 
the ED settings, with 100 having etomidate and 100 having ketamine.  In the pre hospital 
setting there will be 100 having etomidate and 100 having ketamine. 
 
ELIGIBILITY CRITERIA: 
Inclusion Criteria: 
Adult patients age 18 and greater who require RSI for any indication. 
 
Exclusion Criteria: 
1. Children under the age of 18 as these patients have a different hemodynamic profile 
than adults and would require a separate study to clearly elucidate the effect of 
ketamine or etomidate during RSI. 


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2. Pregnant women of any age as these patients also have a different hemodynamic profile 
than adult patients and would require a separate study to clearly elucidate the effect of 
ketamine or etomidate during RSI. 
3. Patients with a known hypersensitivity to ketamine or etomidate will not be 
administered that respective agent and will not be crossed over into the opposite group.  
 
STUDY OUTCOMES: 
Primary Outcomes: 
The primary outcome will be the incidence of post RSI hypotension between patients 
undergoing RSI with ketamine versus patients undergoing RSI with etomidate.  Post RSI 
hypotension will be defined as a 20% decrease in the systolic blood pressure from a patient’s 
baseline. 
 
Secondary Outcome(s): 
Secondary outcomes will include: incidence of first pass intubation success, incidence of 
supplemental blood pressure agents (e.g. vasopressors) required post-RSI, time to additional 
sedative use 
 
STUDY PROCEDURES: 
Recruitment of participants: 
Patients who require rapid sequence intubation are critically ill and are not capable of making 
medical decisions at the time of the procedure.  During these critical moments, surrogate 
decision makers are rarely, if ever present and this procedure is performed as a life-saving 
measure to allow for further medical therapies.  Informed consent of the patient nor a 
surrogate decision maker is possible at the time of the procedure. 
 
Randomization: 
Randomization will be assigned by calendar day beginning at midnight, with etomidate being 
administered to all RSI patients on even calendar days and ketamine being administered to all 
RSI patient on odd calendar days.   
 
Study Procedure: 
Etomidate will be dosed at a standard 0.3 mg/kg and ketamine will be dosed at a standard 2 
mg/kg for the purposes of this study.  Data will be collected from the pre-hospital electronic 
medical record for patients undergoing RSI in the pre-hospital setting and from the inpatient 
electronic medical record for patients undergoing RSI in the emergency department.  Data 
extracted from each record will include ketamine or etomidate dosages and time of delivery, 
sets of vital signs prior to and post-intubation, number of intubation attempts, number of lost 
airways, dose and timing of any additional medications, requirement for additional fluid or 
blood product administration, indication for advanced airway placement, admitting service, lab 
data, past medical history, and standard patient demographics.  The hemodynamic response 
will be measured by assessing hemodynamics for two measurements prior to administration of 
ketamine or etomidate and for two measurements up to fifteen minutes post administration or 


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until an additional sedative medication is administered.  (Please separate sheet that will be 
placed in RedCap once IRB approval has been obtained). 
 
Ketamine and etomidate are immediately availavle for RSI in the pre-hospital and hospital 
settings and are both currenly standard of care for RSI at our facility. 
 
Data Storage: 
All data will be kept in the secure database RedCap.  Only study staff will have access to the 
database. 
 
Safety considerations/Patient safety: 
Etomidate and ketamine are both frequently used in the pre-hospital and emergency 
department setting with an acceptable safety profile.  Etomidate has described adverse 
reactions to include adrenal suppression, pain at the injection site, nausea and vomiting, and 
nystagmus.  Ketamine has described adverse reactions to include confusion/delirium, 
hallucinations, vivid imagery, bradycardia, increased blood pressure, nausea and vomiting, pain 
at the injection site, laryngospasm and nystagmus.  These adverse reactions have not precluded 
use in routine clinical care.  If a patient has a known hypersensitivity or allergy to either 
medication, they will not be given that medication. 
 
 
STATISTICAL CONSIDERATIONS AND DATA ANALYSIS: 
Sample size and statistical power:  To maintain 80% power with a probability of 0.05, 200 
patients will be needed in each arm to detect at 25% difference in SBP (baseline to post drug 
administration effects) 
 
Statistical methods: 
Data will be analyzed using SPSS with a p-value of less than 0.05 being considered significant.  
We will consider a 20% decrease in systolic BP from a patients baseline as significant, and will 
compare the incidence of post RSI hypotension between the two groups.  Several a prior 
subgroups will be evaluated to include patients greater than 70 years of age, trauma patients 
requiring RSI, and those patients whose shock index is less than 0.9 versus those whose shock 
index is greater than 0.9. 
 
OUTCOMES AND SIGNIFICANCE: 
The results from this study will help elucidate a sedative agent that is most appropriate in 
unstable patients across a sepctrum of clinical scenarios to include cardiac dysfunction, severe 
sepsis with septic shock, trauma and the elderly. 
 
 
 
 
 
 


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REFERENCES: 
Bijker JB, van Klei WA, Kappen TH et al. Incidence of intraoperative hypotension as a function of 
the chosen definition. Anesthesiology. 2007;107:213-220. 
 
Miller M, Kruit N, Heldreich C et al. Hemodynamic response after rapid sequence induction with 
ketamine in out-of-hospital patients at risk of shock as defined by the shock index. Ann Emerg 
Med. 2016;68(2):181-188. 
 
Price B, Arthur AO, Brunko M et al. Hemodynamic consequences of ketamine vs etomidate for 
endotracheal intubation in the air medical setting. Am J Em Med. 2013;31:1124-1132. 
 
Sibley A, Mackenzie M, Bawden J et al. A prospective review of the use of ketamine to facilitate 
endotracheal intubation in the helicopter emergency medical services setting. Emerg Med J. 
2011;28:521-525.  
 
Stanke L, Nakajima S, Zimmerman LH et al. “Hemodynamic effects of ketamine versus 
etomidate for pre-hospital rapid sequence intubation”.  Carolinas Virginia Society of Critical 
Care Medicine Podium Presentation. 2017 June 02. 
 
Upchurch CP, Grijalva CG, Russ S et al. Comparison of etomidate and ketamine for induction 
during rapid sequence intubation of adult trauma patients. Ann Emerg Med. 2017;69(1):24-33.