Clinical trial NCT03959189
Conditions: Myotonic Dystrophy, Type 1 (DM1) Myotonic Dystrophy
Keywords: Excessive Daytime Sleepiness hypersomnia
Sponsor: Expansion Therapeutics, Inc.
Start date: 2019-06-17; Completion date: 2020-04-30
Enrollment: 12 participants; Allocation: RANDOMIZED; Intervention model: CROSSOVER

Brief summary:
Participants in this study will receive two treatments, placebo and ERX-963, on different days in a randomized fashion.

The primary purpose of this study is to investigate the safety and tolerability of ERX-963 in participants diagnosed with Myotonic Dystrophy, Type 1 (DM1).

The secondary purpose is to evaluate the potential of ERX-963 treatment to reduce excessive daytime sleepiness / hypersomnia and improve cognitive function in DM1 participants compared to placebo treatment.

Detailed description:
This study is evaluating single administration of two dose levels of ERX-963 to explore the relationship between dose, safety, tolerability, exposure and clinical benefit. This is a multi-center, randomized, double-blind, placebo-controlled, two-treatment period crossover study in two cohorts of participants with DM1.

Participants who have consented and meet eligibility criteria will receive two treatments, placebo and ERX-963, in a randomized crossover fashion with a washout period between the treatments. On treatment days, participants will receive treatment followed by repeated blood collection for pharmacokinetic analysis and administration of a battery of outcome measures relevant to sleep and cognition.

Arms: arm 1: Participants in this arm will receive ERX-963 followed by a washout period. After the washout period, participants will receive placebo. arm 2: Participants in this arm will receive placebo followed by a washout period. After the washout period, participants will receive ERX-963.
Interventions: intervention 1: ERX-963 intervention 2: Placebo
Intervention descriptions: intervention 1: Active medicine intervention 2: Comparator

Protocol documents:
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SAP_001.pdf: