Clinical trial NCT02711852
Conditions: Hematologic Malignancy
Sponsor: SecuraBio
Start date: 2016-04-01; Completion date: 2020-05-04
Enrollment: 19 participants; Allocation: NA; Intervention model: SINGLE_GROUP

Brief summary:
This was a long-term, continued treatment study that evaluated the long-term safety, clinical activity, and overall survival (OS) of duvelisib in individuals with hematologic malignancies that were previously treated with duvelisib in a previous sponsor-approved study.

Detailed description:
Study IPI-145-23 was an international, multicenter, open-label, single-arm, Phase 2 study designed to evaluate the long-term safety, clinical activity, and overall survival data of duvelisib in individuals with hematologic malignancies. Only individuals who have participated in a previous duvelisib study that were approved by the sponsor were allowed to enroll in the study.

Participants in active treatment and participants in survival follow-up were allowed to rollover to this study. For participants on active treatment, participants continued the same dose from their previous duvelisib study administered twice daily for 28-day continuous cycles until disease progression or unacceptable toxicity and then followed in a survival follow-up period. For participants in survival follow-up, participants continued to be followed-up for survival in this study for the duration as outlined in their previous duvelisib study.

Arms: arm 1: Participants received the same dose from their previous duvelisib study. All doses were taken twice daily. Two dose reductions were allowed per participant, but doses were not less than 10 milligrams (mg). Participants received duvelisib until disease progression or unacceptable toxicity.
Interventions: intervention 1: Duvelisib
Intervention descriptions: intervention 1: Administered as oral capsules

Protocol documents:
Prot_000.pdf: 
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V4YVOV	LM45	7V	'4PW	4N	RM	'R		SR	XRU'4P	Q4PO"			
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]4PP4'4RT	Q4PO	SPP	'	RM	LPPLRN	4R	*!.!		RM	P5URV	YR	RONT	W	
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