Clinical trial NCT02276963
Conditions: Neuromyelitis Optica Neuromyelitis Optica Spectrum Disorder
Keywords: Transverse myelitis, optic neuritis, neuromyelitis optica
Sponsor: Johns Hopkins University
Start date: 2016-01-01; Completion date: 2019-02-15
Enrollment: 6 participants; Allocation: NA; Intervention model: SINGLE_GROUP

Brief summary:
Ublituximab (also known as LFB-R603) is a monoclonal antibody that specifically binds to the trans-membrane antigen CD20. The binding induces immune response that causes lysis of B cells.

The rationale for using ublituximab in neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorder (NMOSD) is based on the known roles of B cells, antibody production and plasma cells in the pathophysiology of NMO. NMO is characterized by the presence of an anti-Aquaporin-4 (AQP4) antibody, which can only be produced by differentiation of B cells to plasma cells. Because these anti-AQP4 antibodies may be pathogenic, B cells recognizing AQP4 may be directly involved in the disease process as well. B cells also play a role as potent antigen presenting cells in NMO. The strongest evidence of the importance of B cells in NMO comes from studies of B cell depletion, most commonly with anti-CD20 monoclonal antibody, rituximab (Rituxan®).

Rituximab has been shown in five retrospective and two prospective studies to be effective in reducing NMO relapses up to 90% and achieving remission in up to 80% of patients solely by its action on CD20+ B cells, despite no change in plasma cell population and anti-AQP4 antibody titers. These human trials strongly suggest a critical role for B cells in the pathophysiology of human disease. While typically used in the prevention of disease, B-cell depletion may be beneficial in the treatment of an acute relapse as well. Emerging evidence indicates that peripheral B cells are activated during a relapse and plasmablast production of anti-AQP4 antibodies spikes. B cells are also found within acute lesions of the spinal cord and optic nerve suggesting roles both in the blood and in the central nervous system during a relapse.

Detailed description:
The overall objective is to assess the safety of ublituximab as add-on therapy to steroids for treatment of acute optic neuritis and/or transverse myelitis in NMO and NMOSD.

Primary Objective To assess safety of acute B cell depletion in NMO subjects with acute relapse of optic neuritis or transverse myelitis who are treated with ublituximab + glucocorticoids beginning on dose administration and ending with recovery of B cells.

Secondary Objectives

* To determine the B cell depletion pharmacokinetics of ublituximab in the NMO patients population with monthly B cell counts for up to 9 months.
* To determine the frequency of adverse events with ublituximab in this patient population.

Trial Design Given the severity and the consequences of relapse in NMO, placebo treatment without steroid treatment is unethical and use of an active treatment is considered mandatory. The potential of currently utilized drugs and techniques to reduce the inflammation in NMO has been established primarily through expert consensus and small open label and retrospective studies.

This is a Phase 1 open-label, standard-of-care, single treatment arm, unblinded, single center interventional trial in NMO/NMOSD patients in which experimental subjects will receive one (1) infusion of 450 mg of intravenous ublituximab at the onset of an NMO exacerbation in addition to standard of care treatment with daily intravenous glucocorticoid at 1000 mg for five days.

Arms: arm 1: Ublituximab 450 mg intravenously once on day 1, plus glucocorticoids 1000 mg intravenously daily on days 1-5
Interventions: intervention 1: Ublituximab
Intervention descriptions: intervention 1: Monoclonal antibody that specifically binds to the trans-membrane antigen CD20, which induces immune response that causes lysis of B cells.

Protocol documents:
Prot_SAP_000.pdf: 
Brief Title: Ublituximab for Acute Neuromyelitis Optica (NMO) Relapses 
 
Document Date: August 3, 2017  
 
Document: Protocol and Statistical Plan  
 
ClinicalTrials.gov ID: NCT02276963 



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n*Aseo7yLsthfig
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n*tMhTiAehpAn7TAseo7yLsthfig
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1157fAs/AE7eL/Tgfe7s/7o/tME7oL115MtooLfL7oE:rhortfLf




X  mlmUb; 
b (oX(a; a sb X  mlmUb; l;sa;; ;;;oi s ulUllulsL)bl;(Xa ;;
lmuo ;m
;mC;smXa X Dsal msl LamsX;s mbmlmUu ;lamC;Dlm
sb a(slm Xk mfaX;(lmuaX)

oi s;xo;sbk xlmlxoxa lXouslmU uu;ax(Xl;lmUsu ;s®)WJa sasu
uLx(baLs aomssa mXauulmsb sXlumX  lk oulsowlxsb X(L)aXsba; 
nbabk masX  lk  uu (u slmUx lslam;lmsb (;s9%xamsb;
CXlsowlx6a soxox6aX ulFox6oulsowlxD6maXxu uuaomsa Wc%®J
a sasuuLx(baLs ;xo;s (X ; mslmsb lXouslam6am lXx Lulxls  uan
Lsax sXL(m ua 86+69Sm%®)aXsba; nbabk X  lk  uu
 (u slmUx lslamlmsb (;s9%xamsb;6xlmlxoxa ®)WJa sasu
uLx(baLs ;b;sa  uu;)b naXtlmUbL(asb ;l;l;sbsnb m(sl msb;m
os sst auuanlmU(X k mslk sb X(Lnlsb uu (u slmUU ms;6sb 
X xlmlmUaXX soXmlmUc uu;X k XLUUX ;;lk mxLsuLF sb sst)
s XalX sx msb; 
	lUba; C9®®®xUDlmsXk mao;x sbLu(X ml;auam nluu Ulk msauu;oi s;
nlsb
cam lXx slk u ;lam;sam; sa sb sstaXlmUsa;smXa 
X ); XuL;(a;;lu lmsb s XalX sx msb; 6+W®xUa lmsXk mao;
oulsowlxnluu xlml;s X am sa b;oi s mXauu )
  aXsnluu  ao; amUlklmUsb oulsowlx; XuLlmsb ;s XalsX sx ms
(Xa ;;;(a;;lu )
 ;oi sh;xl;;lamaXsXm;  Xsasb abm;	a(tlm;
	a;(lsul; uL 6;smXa X sb X(Lnlsb;s Xal;nluu Ulm;;aam;
(a;;lu ssb aos;l ba;(lsu)b ;oi sxLsb m mXauulmsbl;sXlumX  lk 
am a; a oulsowlxamsb  lX;sLa ba;(lsulFslamssb abm;	a(tlm;
	a;(lsul sb sXm;  Xst ;(u nlsblmsb s XalX sx msb; )
uu;oi s;nba lusaulmluuLX ;(amLLWnluu X axx m  aX(u;x
 wbmU ;( X;smXa X ) m  lluX ;(am; l;U m XuuLam;l X m
lx(Xak x mslmsb ;( l l  llsC;Dsbsu sasb ba;(lsulFslam) ( mlmUam
sba; ;( l l  lls;6sb Xls XlsbsX Xaoslm uLo; sabm;	a(tlm;sa
lmls sX sx msX ;(am; C;DlmxasaX6; m;aXL6osamaxlmkl;ou omslam
X 3
9) mlx(Xak x mslm;sX mUsbLsb asaX ; Xbaomlu;sX mUsb;u 
Lsu ;s9 ouu(almslmsu ;ssnal;aus xo;u ;a su ;sam ulx6aX
%) mlmX ; a snaL usomlmU aXtomls;lmsu ;sam    s ulx)
8) 
x(Xak x mslman umfaXu X omslam Xaxlmamslm m sasu ;s
(XslukauomsXLamsXau)
+) mlx(Xak x mslmkl;ouolsLo;lmU ;l m uu m Tolku msa V%
ulm ;)

 ;oi s;amasX TolX X ;o nlsb(u;x wbmU  o; sb L ou luusb 
ulmluXls Xlak 6m
xL ( X aXx saam lXxX ;auoslama sb 
lm uxxsaXLu ;lamsaax(X saxl;;lam
); amsb 
masb X
ulmlu saX;6sb sX slmU(bL;llmxL(Xa  sal;bXU sb ;oi sbax aX
bmU sb (umsa ;us lxxoma;o((X ;;lamsa(u;x wbmU  aXamslmo 
sX sx msa sb os  w Xslam)  aX l;bXU  Xaxsb ba;(lsu6sb ;oi s
nluu ;b ou  aX auuano(lmsb ulmlnlsblmS®L;mExamsb;)
lmlmU;L
sbsxLlm uo m  ;uslamsa(u;x wbmU sL(luuLlmuo 
 ws m;lama  mbm x ms6lmkauk x msa m nX ;a sb m Xkao;;L;s xaXm
lmX ; lmsb X a %bL( Xlms m;lsL)	l;saXluuLxamUsb f


;oi s;sX s sabm;	a(tlm;6((Xawlxs uLW®Ja f;oi s;
lx(Xak  XaxX u(; nlsb;s Xal;uam )b asb XW®JX TolX  ;us X 
nlsb(u;x wbmU )
u;xwbmU X sx msb; 
baou;oi s;masx  sak ulmluXls Xlsa l;bXU bax 6 ;uslamsa
sX sx msnlsb(u;x wbmU l;;smXa X )

b (u;x wbmU sX sx ms(b;  Ulm;ssb  ma sb s XalX sx ms
b; mnluuu;so(sa9+L;)oXlmUsb u;xwbmU X sx msb; 6
;oi s;nluuom XUa9)®r9)Wkauox ;a (u;x wbmU  k XLasb XL
aXlmUsa;smXa X )ssb  ma sbl;(b; 6; am
xL 
( X aXx saax(X saxlsslmU
)
 mL oXsb Xos lxxoma;o((X ;;lk 
sX sx ms aXsb os  uX l;X TolX m(Xakl aXlmUsa;smXa 
X 6sb ;oi snluuamslmo sa  auuan  aX;  sLl;;o ;6ossb ulmlu
   lLsnluumas lmuo lmsb ;ssl;slumuL;l;)	l;saXluuLxamU
f(sl ms;sX s ssb abm;	a(tlm;	a;(lsu6((Xawlxs uLSWJa 
f(sl ms;nbaax(u s (u;x wbmU X l;bXU  auuanlmU
ax(u slama sb (u;x wbmU )

auuanco(
k XLxamsb s Xl;bXU 6;oi s;nluu  auuan nlsbxamsbuL uuaoms;
omslusb lX uuaoms;X (u s saxlmlxoxa ®)WJ aX(sl ms;nbanluuamslmo 
sa sX s nlsbc uu (u slmUU ms; aX(X k mslk X 6aXlmUsa;smX
a X 6aXsaxlmlxoxa WJ aX(sl ms;nbanluuo; asb X(X k mslk ;sXs Ul ;)

mlslam6ax(u s uaaaoms;nlsbl   X mslusasXtm osXa(bluaoms;m
ax(u s x saul(Xa lu ;nluu ax(u s xamsbuL;n uu)

b ; amXL   lLaosax l;m oXauaUl omslams auuano(S®L;mE
xamsb; s Xlmlsluba;(lsulFslam aXsb os X u(; )
mlslamsasbaXaoUb
bl;saXLm(bL;lu wxlmslam6lmuolmUXslmU6kl;ou wxlmslamm
slx nut6X ; Xb
a sb ;(lm nluu ( X aXx sLS®saax(X sa
sb X u(; u ;lam)

KBODBGBRG
X  mlmUCL®D6s XalX sx msb; CL;9saWD6u;xwbmU 
X sx msb; 6l m  ;;XLCL;Esa%®D6mauuanco(CxamsbuLuaas ;s;
mkl;ls;amL;S®m9I®D)
G OBC 
DOURBNC
gNO4
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nlsbl   X msluC8(Xsl   X mslul; (su D
•
 Xoxb xl;sXL
•
 XauaUL	
6	6	C  (( mlwD
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 Xox(X UmmLs ;s0s;X  mlmUmssb  ma sX sx ms)
•
lXlmaU mu k u
•
 uuaomsLulxls  uanLsax sXL(m u

CGRKUF CRO
R GRG
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
a sb    s X CXlm6 Xklu;(lm 6sbaXl;(lm Dnlsbmnlsbaos
UaulmloxamsX;s)
NGBCT TBF C
uu;oi s;nluuX  lk WL;a lmsXk mao;9®®®xUx sbLu(X ml;auam 
CX   XX saU m XluuL;p;s Xal;eD;( Xsb oXX ms;smXa X )

oi s;nluuuuX  lk +W®xUfLa lm o; ak X aoXbaoX;;ua; sasb 
am; sa ;s XalsX sx ms;(a;;lu 6oXlmUsb s XalX sx msb; )
b X  aX uu;oi s;nluuX  lk H;s Xal;)

uu;oi s;nluuX  lk (X cx lslam(XlaXsalm o;lama )



K F BRBNCi
((Xawlxs uL8®xlmos ;(XlaXsasb lm o;lama +W®xUfLa 6;oi s;nluu
 (X cx ls nlsbmmslbl;sxlm Cl(b mbLXxlm %WxUaX Tolku msD)
; a aXu sxlma(b mEW®xUCaX Tolku msDnluu uuan  aX;oi s;nba
 w( Xl m   k XaX(LX wl6aX;ulmluuLnXXms )


COUGBNCC
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KBR KB
oi s; ulUlu  aX mXauux msxo;sx  suua sb  auuanlmUXls Xl3
9) u mnluulmUsa(Xakl nXlss mlm aXx am; ms)
%) 9Ic9®®L X;a U )
8)  nos a(slm oXlsl;mfaXsXm;k X; xL ulsl;)m nulmlu k msl;
  lm ;ulmluuL;lUml lmsm oXauaUl  llsC;Dam(bL;lu wx6mas
ssXlosu samasb Xl; ; (Xa ;;6nblbl;l   X ms Xax; ulm 
m oXauaUlu wx6mssXlosu sau ;lamlmsb ;(lmuaX6a(sl
m Xk aXXlm;s x) n;Lx(sax;xo;s X (aXs nlsblm9®L;a 
am; s)
+) am lXx aXblUbuL;o;( s lUma;l;a aXlmUsasb %®®E
X kl;lam;a sb lmU XbotlUma;slXls Xl aXClmU Xbot6
%®®ED6aX+(a;lslk ( Xsb ol ulm ;)aX6
;oi s;xo;sbk sna;auos Xls Xl3
) a(slm oXlsl;
) xL ulsl;
Csu ;ssnaa sbX  ;o((aXslk Xls Xl3
) (X ; m a amslUoao;;(lmuaX
u ;lam ws mlmUak XsbX  
aXxaX k Xs Xu; Ux ms;6
) 
Xls Xl;sl; LlmUsb X kl; amulUma;slXls Xl
 aX2auxm6%®99.
 ) c
UC+Dlm; Xox)
aX6;oi s;xo;sbk uamUlsolmuuL ws m;lk sXm;k X; xL ulsl;
CDX oXX msl;aus a(slm oXlsl;C
Dflus Xua(slm oXlsl;
CD6aXa(sla;(lmuxousl(u ;u Xa;l;CDsbsl;c
UaX+
mslaL(a;lslk )
W) b  uuaomsxo;s maXxuCWc%®Ja sasuuLx(baLs ;Dlm;oi s;
nbabk masX  lk masb X uu (u slmUsb X(Llmsb (;sL X)aX
sba; am uu (u slmUsb X(Lnlsblmsb (;sL X6 uuaomsa s
u ;s®)WJa sasuuLx(baLs ;l;m  ;;XL)
E)   xu ;oi sl; ulUlu sa ms Xsb sXlul ;b l;3
o as(X UmmsaXmoX;lmU0
o  mamcblu XlmU(as msluCl) )nax mnbabk b
bL;s X saxL6X (a;scx ma(o;u6nblbl;  lm ;5%L X;
nlsbaosx m; ;aX6lm  xu ;oi s;nbabk   m(a;sc
x ma(o;u aXq%L X;6xo;s am lXx nlsbauulu 
slxouslmU	aXxam C	Dm ;sXlauu k u;D6bk asbakXl ;
;oXUluuLX xak aXbk oXX msaox ms souulUslamD



 bluc XlmU(as msluCl) )nax mnlsb omslamuakXl ;mma
aox ms lx(lXx msa aklosuaXos Xlm  omslamsbsnaou
o; ;s XlulsLD)bl;s UaXLlmuo ;nax mnlsb
aulUax maXXba C k m; k X D6nax mnbaX ( Xlx ma(o;uaX
bk io;s Uomsax m;sXos )
o oi sb;m Uslk ; Xox(X UmmLs ;ss;X  mlmUmUX  ;
saam a sb  auuanlmU3
) ax(u s ;slm m  Xaxlms XaoX;  aXsb ( Xla Xax
am; mslmsasb sXluomsluExamsb; s Xsb u;sa; a 
lmk ;slUslamu(Xaos0aX6
) am;l;s msmaXX so; a am a sb  auuanlmU (su 
x sba;a lXsbamsXau aXsb ( Xla Xaxam; mslmsasb 
sXluomsluExamsb; s Xsb u;sa; a lmk ;slUslamu(Xaos3
l) XuamsX (slk ;C lsb Xaxlm aX(XaU ;s Xam amuLD
ll) 
mi su (XaU ;s Xam 
lll)  kamaXU ;sX ulx(ums;
lk) ;sXaU mlkUlmuXlmU
k)  Xosm ao;amsX (slk (sb ;
kl) 
msXos Xlm  kl C
DaXlmsXos Xlm ;L;s xC
Dnlsb
aox ms  luoX Xs a q9J( XL X
kll) u (Xsm X;s XlulFslamCk; saxLnlsbaox msslam
a Faa;( XxlD(XlaXsasb   xu ;oi sh; msXLlmsasb 
sXlu0sbl;xu xo;s sb ;au (Xsm X aXsb ;oi s
klll) aou XXl Xx sba3amaxmmauo;lk (
Cl(bXUxaX Xklufkous(;DnlsbkUlmu
;( XxlluU msC axfU uf luxfX xf;o((a;lsaXLD)

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oi s;x  slmUmLa sb  auuanlmUXls XlX CNR ulUlu mmmas mXauulm
sb sXlu3
9) oXX ms kl m aXtmanmbl;saXLa ulmluuL;lUml lmslm  slam
lmuolmU3
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;L;s xlsX sx ms;ob;6osmasulxls sa3(XaUX ;;lk xousl au
u ota m (bua(sbLCD6bXamlX mulm  slam6bXamlb ;s
lm  slamnlsbXambl s;l;6so Xoua;l;6aXslk b (slsl;)
) X klao;; Xlao;a((aXsoml;slaXsL(lulm  slam;)
) 	l;saXLa (a;lslk ; XauaUL aXb (slsl;)
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 ) 	l;saXLa (a;lslk ; XauaUL aX	
)
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 X Xuamso;lam6;(lmuaXax(X ;;lamD
8) ;saXoXX msbl;saXLa x luuL;lUml lmsk X;     s;ClmuolmU
uu XUlX slam;D Xax3


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) oXlm aXxao; fboxmblx Xlmslal ;
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)  XkluXlmaxsU 9aXu ;;
) amclmk;lk ;u uum;Toxao; uu;tlmXlmax
) m XlUma; ;nlsboXslama ax(u s X ;(am; 
CX xl;;lamD5WL X;
ABGRNKrN A FRNONTBFOBTCCr 3OU GGUL R KNF
SKRBBSRBNCtK TKO GGN K GSNCG o
W) lUml lmsamoXX ms6omamsXauu x luamlslamlmuolmU6osmas
ulxls sa6Xl6X mu6b (sl6b xsauaUlu6U;sXalms ;slmu6 maXlm 6
lxxoma  ll mL;LmXax 6(ouxamXL6 X Xu6(;LblsXl6aX
m oXauaUlul; ; nblbaou   ssb ;oi sh;;  sL6lx(lXsb 
;oi sh;X ulu (Xsll(slamlmsb sXlu6lx(lXsb  kuoslama 
 m(alms;6aXm  ;;lss sb o; a x lslammasuuan Lsb (Xasaau6
; s Xxlm Lsb 
a sb sXlu)
E) ; a mlmk ;slUslamuXoUaXasb X w( Xlx msusb X(L aXamlslam
asb Xsbmnlsblm+n  t;6W(bXxatlm slbu ulk ;aXoXslama 
lauaUlu    sCnblb k Xl;uamU XD(XlaXsa;X  mlmU)
G) oXX ms(Xsll(slamlmmLasb Xlms Xk mslamuulmlusXlu)Xsll(slam
lmmamclms Xk mslamusXluX TolX ;((Xakua sb (XasaauLlmk ;slUsaX)
I) oi s;nbaX amoXX msuLX  lklmUmLasb Xlmk ;slUslamuU ms;6aX
bk (Xsll(s lmmlms Xk mslamuulmlusXlunlsblmsb u;s%9L;6
aX;oi s;nbabk   mklms nlsbulk klm q%xamsb;(XlaX
sasXlulmuo;lam)
S)  o; sb X l;momtmanmos(as msluXl;t aXk X;  k ms;lm
moX;lmUlm ms;; amXLsasX sx msa sb xasb Xnlsboulsowlx
X ;s   lmU;baou l;amslmo l sb xasb Xl; mXauu )
UF KN 
GUL RG
lk CWD;oi s;nluu  mXauu saX  lk H;s Xal;)
NSUORBNCG

CR CRBNClNlK Rg
4ruu;oi s;nbaX  lk am a; a sXlux lslam
CD

 KKNRNNOg4ruu;oi s;nba( X aXx uukl;ls;lmaXm nlsb
(Xasaaunlsbaos;lUml lms(Xasaau klslam;aXklauslam;

  RrNSUORBNCruu;oi s;sbsX  lk am a; a sXluXoUCD

RRBGRBOBGGU G
XlxXL  sL;; ;;x ms;3;oxxXLa sb mox Xm( X msU a ;oi s;
nlsbmLk X;  k msCD6mL; Xlao;k X;  k msCD6k X;  k ms;
u lmUsa( Xxm msl;amslmoslama sXluXoUmsXluXoUcX us k X; 
 k ms;nluu X (aXs )

 amXL  lL;; ;;x ms;3bmU lmm oXauaUlaosax ;amsb 6lx 
%Wcaasutm	;u ; Xaxxl;;lamsal;bXU CLWaX%9D6m
 auuano(CL;S®m9I®Dnluu muLF L(lX scs ;s;nlsb;lUml lms(c
kuo ;am;l X u ;;sbm®)®W)ulmlum oXauaUllx(Xak x msl;axxamuL


a; Xk lm5EEJa ;oi s;sX s ssb abm;	a(tlm;	a;(lsu)b 
 UX  a lx(Xak x mslmsbl;sXlu(a(ouslamb;mas  m Tos uLTomsl l 
bl;saXluuL)L
6u mUsba %bL( Xclms m;lsLmu mUsba 9c(a;samsX;s
 mbm x ms;baou ;su aXX o Ll;bXU )(lX scs ;snluu o; 
saax(X sb ; kuo ;nlsb;lUml lm am;l X s(ckuo ;u ;;sbm®)®W)

FSO GBa 
b ;x(u ;lF a W;oi s;lmsbl;;lmUu Xx;soLCH;s XalDl;; am
  ;llulsLmuaUl;sluam;l Xslam;amsb mox Xa ;oi s;sbsnluu m;oX 
X ulu ;  sLX (aXsa oulsowlxcx ls  uu; (u slamlmsb (sl ms
(a(ouslam)

mlm ( m mssm  sLamlsaXlmUaXCDnluu ax(a; a  lk 
x x X;nlsbsu ;sam x x Xnbal;m
m  slao;l; ; ( lul;s6
	 xsauaUl;s6 oXauaUl;s6ssl;sllm6mmasb Xlm ( m ms w( Xsnlsb
 w( Xl m am;; ;;lmU;  sL)bX  a sb x x X;nluu am;s  ssb 
abm;	a(tlm;mlk X;lsL)b nluu X kl nlmUsb ;  sLs s Xsb  lX;s
sna;oi s;X  mXauu max(u slmUsb s XalX sx msb; sa s Xxlm 
l ls;  saamslmo sb sXlu)b nluu;oxlssb lX lmlmU;sasb (am;aX
 s X k XLx  slmUmsasb 
)x  slmU;m lmc( X;amaXkl
s u am  X m aXaxlmslama sb asb)b ssa o;  aXX kl nLsb 
nluu souXnsX aX lmsb s; )b ulmlusnluu 
xamlsaX Lb X( osl;mnluu To XLc X  (XlaXsaX kl nLsb )

UKRBNCN 
UL R
KRBBSRBNC
(saSxamsb;






K DBRBNCGC  BCBRBNCN  KFG

mslaL
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
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
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m ( m mssbl;axxlss  C
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U

xxomaUuaoulm

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ms Xmslamuam  X m am	Xxaml;slama  bmlu TolX x ms;
 aX Ul;sXslama bXx oslu; aX	oxm; 



mk ;slUslamu llmuXaos



m;slsoslamu kl naX



msXk mao;
t
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x
amauamumslaL
 
 lulslamXL aX UousaXLslklsl ;
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Um sl ;amm 
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
ousl(u u Xa;l;

c
slamum X
m;slsos raXtlmUXao(

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
 oXaxL ulsl;(sl( sXoxl;aX X

(sla;(lmu;u Xa;l;


K DBRBNCGC  BCBRBNCN  KFG

bXxaLmxlaXXaUX ;;lk l; ; 

XaUX ;;lk ousl au ota m (bua(sbL
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 XXasaau s
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X   XX  Xx

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
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 oXX ms
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ssl;slumuL;l;um
x
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L;s xXUmu;;

 XoxXas lmu sXa(baX ;l;
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	
aXu	 usbXUmlFslam



0 
0o0 

 oXaxL ulsl;(slCDl;; k X 6 xL ulmslmUosalxxom l; ; a sb  msXum Xkao;
;L;s xsbs(X   X msluuL   s;sb a(slm Xk ;m;(lmuaX)usbaoUbbl;saXluuLam;l X 
;osL( a xousl(u ;u Xa;l;CDnlsbak Xu((lmU;Lx(sax;6l;l;slmsXlauaUluuLm
(XaUma;sluuLmb;(sba(bL;lauaULomX ;(am;lk sasL(lusX sx ms;2 lm;b mt X
%®®G0lxXaoUb6 su)6%®9%.)
m%®®+6mmslaLsXU slmUsb ns Xbmm u(Xas lm6
To(aXlmc+6n; aomsa ;;als nlsb)ax(X sa6 wblls;mau XU s
am; s6(aaX X(XaUma;l;6mXXlsLa  X Xa;(lmu uolaulUauamu
Um;)sst;
sL(luuL(Xao xa Xs sa; k X l;lulsLsbsu ;saoxouslama l;lulsLnlsb b
sst0 sn  msst;6(sl ms;U m XuuLX xlmm oXauaUluuL;su nlsbaos kl m a 
(XaUX ;;lk  s XlaXslam)b X  aX 6lsl;XolusbsUUX ;;lk sX sx ms aX bX u(; l;
a(slxlF sa(X k msl;lulsL)

   s;(X axlmmsuL  xu ;6nlsb  xu saxu Xslaa E)W39)b X uslk  X To mLa 
xamU xL ulmslmUl;aX X;l;Tols kXlu 6 lmUblUb Xlm;lm6	l;(mlm Xlm
(a(ouslam;ax(X sanbls ;)b   n(a(ouslamc; (X ku m ;sol ;a amos 
(Xakl (X ku m Xs ;a ®)8%sa8)9( X9®®6®®®lmsb mamcnbls (a(ouslam2mbUa(u6 s
u)6%®9®.

ulmluuL  lmls l;  lm Lbl;saXLa a(slm oXlsl;mbl;saXLa sXm;k X; xL ulsl;
nlsbmamcXlm
6uamUlsolmuuL ws m;lk xL ulsl;u ;lam;mfaX(X ; m a sb c
U
laxXt X) Xam Uslk (sl ms;nlsbsXm;k X; xL ulsl;ma(slm oXlsl;xo;sbk 
uamUlsolmuuL ws m;lk xL ulsl;mXlm
sbsl;massL(lu aXxousl(u ;u Xa;l;)
( sXoxl;aX XCDl;  lm ;+mslaL(a;lslk lmlklou;nlsbIra(sl
m oXlsl;aXsXm;k X; xL ulsl;)

ax(Xl; sb ;(sluuLulxls ;LmXax ;a uamUlsolmuuL ws m;lk sXm;k X; xL ulsl;
CD6X oXX msl;aus a(slm oXlsl;C
Dflus Xua(slm oXlsl;CD6m;lm
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2 uum X6 su)6%®9®.)lFFaa6 su)6X (aXs sbsGa 98CWEJD(sl ms; Xaxo;mL
 k ua( ulmluuL  lmls  s X auuanco(slx a su ;s%L X;nlsbsb asb X;lwC+EJD
X xlmlmU) lm;b mt X su)6(Xa;( slk uL;sol %S(sl ms;nlsb lX;s k msa )
lsblm9L X6Ea sb 99; Xa(a;lslk C+HD(sl ms;bX u(; a xL ulsl;Clmlslk a 
X oXX mssXm;k X; xL ulsl;DaX k ua( a(slm oXlsl;Clmlslk a m oXaxL ulsl;a(slD)L
amsX;s6ma; Xam Uslk (sl ms;X u(; ak X9rGL X; auuanco()m;lmbk 
;lxluXm oXalxUlmU6; XauaUlu6mlxxoma(sbauaUlubXs Xl;sl;6msb l   X m l;
(XlxXluLam a u;;l lslam;lm(msb ; lmlklou;X lUma; nlsb6oslmaXsb
x XlmoXa( 6sb ; (sl ms;X lUma; nlsb2s;oat6 su)6%®®G0lmU Xbot s
u)6%®®G.)

b oXX ms;smXa X  aXsX sx msa os sst;a asba(slm oXlsl;m
sXm;k X; xL ulsl;l;WcLaoX; a blUba; x sbLu(X ml;auam C9®®®xUluLDClxXaoUb
%®9%D)
m;ax (sl ms;6sbl;aoX; a ;s XalsX sx msl;;o  ll mssa;o((X ;;lm uxxslam
mX k X; ;ax m oXauaUlL; omslam)saX;sbsxL(X ls;o ;;nlsb;s Xal;uam 
lmuo ;xuuu ;lamoUbs XuLlmsb (Xa ;;mamoXX ms(X k mslk 
lxxoma;o((X ;;lam)
mxmL(sl ms;6;s Xal;X mas;o  ll mssa;o((X ;;lm uxxslam6
msX sx ms ;uslamsa(u;x wbmU l;m  ;;XL)lk Lu ;a 9)®r9)Wkauox  wbmU ;
X TolX mlslamu%cn  tlm(sl msba;(lsulFslamm msXuulm sb s X)u;x wbmU 
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 wbmU l;;smXa X lm;s XalcomX ;(am;lk (sl ms; o; lsl;W®cG®J    slk lm
X olmUslk lm uxxslammX olmUlm uxxsaXLxU lmsbl;(sl ms(a(ouslam


CFF (laXtan;tl%®9®D)uslxs uL6m oXauaUlX ak XL s XblUba; ;s Xal;m(u;x
 wbmU m ;sXsl l lmsasbX  UXao(;3UXao(sbsa ;maslx(Xak suu6UXao(sbs
lx(Xak ;;ax osxlmslm;;lUml lmsm oXauaUl  llsmUXao(sbslx(Xak ;n uul mas
tsa; ulm )

b Xslamu  aXo;lmUoulsowlxl;; amsb tmanmXau ;a  uu;6mslaL(Xaoslamm
(u;x uu;lmsb (sba(bL;lauaULa )l;bXs XlF Lsb (X ; m a mmslc+
mslaL6nblbmamuL (Xao Ll   X mslslama  uu;sa(u;x uu;) o; sb ; 
mslc+mslal ;xL (sbaU ml6 uu;X aUmlFlmU+xL lX suLlmkauk lmsb 
l; ; (Xa ;;;n uu) uu;u;a(uLXau ;(as msmslU m(X ; mslmU uu;lm)b 
;sXamU ;s kl m a sb lx(aXsm a  uu;lmax ; Xax;sol ;a  uu (u slam6xa;s
axxamuLnlsbmslc%®xamauamumslaL6XlsowlxClsowm4D)lsowlxb;  m;banm
lm lk X sXa;( slk msna(Xa;( slk ;sol ;sa     slk lmX olmUX u(; ;o(sa
S®Jmbl klmUX xl;;lamlmo(saI®Ja (sl ms;;au uLLls;slamam%®H uu;6 ;(ls 
mabmU lm(u;x uu(a(ouslammmslc+mslaLsls X;)b ; boxmsXlu;;sXamUuL
;oUU ;sXlsluXau  aX uu;lmsb (sba(bL;lauaULa boxml; ; )blu sL(luuLo; lm
sb (X k mslama l; ; 6c uu (u slamxL  m  llulmsb sX sx msa mos X u(; ;
n uu)x XUlmU kl m lmls ;sbs( Xl(b Xu uu;X slks oXlmUX u(; m
(u;xu;s(Xaoslama mslc+mslal ;;(lt ;) uu;X u;a aomnlsblmos u ;lam;
a sb ;(lmuaXma(slm Xk ;oUU ;slmUXau ;asblmsb uaamlmsb  msXum Xkao;
;L;s xoXlmUX u(; )

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ETKNUC
ulsowlxl;mak usblXU m Xslamblx Xlmslc%®xamauamumslaLla mUlm  X  aX
 mbm slklsL6 wbllslmUomlTo UuLa;Luslam(Xa lu nlsbuan Xosa; ams ms)
ulsowlxb;  m ;lUm salmsXao ;o( XlaXmslaLc ( m ms uucx ls 
LsasawllsLCDnblu xlmslmlmUax( slslk ax(u x msc ( m msLsasawllsLCD)
ulsowlxb;u;a  m xam;sXs salmo (XaUXxx  uu sbCD)ulsowlxb;
omlTo (Xas lm; To m 6sXU slmU (lsa( ;am%®massXU s LXlsowlxaXa soxox)

K OBCBODOURBNCGN OBRU3BF


b xamauamumslaL6oulsowlx6 xam;sXs m mbm lulsLsatluubXaml
uLx(baLslu ot xlCD uu;ax(X saXlsowlx)ulsowlx xam;sXs lx(Xak N
X  (saX


CN


Df9ElmlmUmN


 ( m ms    saX omslam;ax(X sa
Xlsowlx)lslamuuL6oulsowlxlmo blUb XlmklsXaUlm;s uu;6mblUb X
N


x ls lms Xu otlmc%C
%D(XaoslamLN


HoXts uu;2 ax o  su)%®®I.)
ulsowlx xam;sXs blUbUlm;sasb(sl msc Xlk  uu;m	 uuulm ;)
Ulm;ssb 	 uuulm xa;6oulsowlxn;a; Xk salmbllssb am;slsoslk uLslk c
M;oXklku(sbnL6mlmo sb  w(X ;;lama uamUnlsblmbllslama sb 
8c
(sbnL)ulsowlxu;almo sb  w(X ;;lama (Xac(a(sasl saX;6; m;lslFlmUxa; uu;
sa
x ls (a(sa;l;)2Xlstl su)6%®99.




b mslsoxaX    sa oulsowlxn;ax(X sasbsa Xlsowlxnlsbb xasb X(Llm
 auulouXuLx(baxCD6mxmsu  uuuLx(baxCDw maUX sxoXlm xa u;)lmUu U ms
oulsowlx xam;sXs a; cX us mslcsoxaXslklsLnlsb9®®JsoxaXUXansblmbllslamlm
sb w maUX ssa; a 9®®xUftU6m;o( XlaXsoxaXUXansb uLC%9L;Dax(X sa
Xlsowlx)ulsowlxu;a xam;sXs ;o( XlaXmslcsoxaXslklsLax(X saXlsowlx
Ulm;sw maUX s;suua; u k u;)2;s k ; su)6%®99.



	
A CNClOBCBORN3BNONTrSKNTKF.GS K NKF NKBCTRN
	VTUB OBC 
IX ulmlu  sLkuoslama las bmauaUL Xlk bXx oslu;eC
mk ;slUsaXXaboX D)
b sawllsL;sol ;( X aXx sa ;sul;bsb ;  sLa oulsowlxn X amos aXlmUsa
aaaXsaXLXsl CDX TolX x ms;6lmuolmUkulslama sb muLslux sbao; 
 aXsb ; XoxmuL;l;a oulsowlx)b ulmlusawlauaUL;sol ;amos sas nlsb
oulsowlxX ;oxxXlF lmu 9 uan)

O 0iN3BNONTr

rS N GRUr
 GRGrGR F
 RANN 
FBCBGRKRBNC
NG G
 SNKRC5

lmUu a; 
sawllsL
LmaxauUo;
xamt L


lmUu a; %n  t;
a; Xkslam
®6®)869®m9®®
xUftU

8%IGS
 ;
 ( s a; 
sawllsL
LmaxauUo;
xamt L


  tuL aX+n  t;
®69®mW®xUftU

8%II®
 ;
Lsatlm X u ; 
LmaxauUo;
xamt L


W6%®6E®xlmos ;m
EbaoX;
9®mW®xUftU

8%II®
 ;
ausau Xm 
LmaxauUo;
xamt L


+n  t;
9®mW®xUftU

8%II®
 ;
ausau Xm 
 n um
nbls Xls

m
lmUu a; 
9®xUftU
%®®G®E®W
 ;
osU mllsL
Cx ;s ;sD
uxam uu
sL(blxoXlox

mklsXa
f
®696869®68®m
9®®’Uf(us 

®G®W%%
 ;

xxomaU mllsL
LmaxauUo;
xamt L


lmUu a; 6%cn  t
a; Xkslam
®)869®m9®®xUftU

8%IGS
 ;

xxomaU mllsL
LmaxauUo;
xamt L


+cn  t
9®mW®xUftU

8%II®
 ;

3 msX 
ms Xmslamu awlauaUl )	iIriIti tlt t iIr,c3 msX   b Xb ;lauaUlTo ;
CiIrtrt t (rD)
3
m;slsos;s oX luu C  (Inr	i(IInID


m;lmUu ca; sawlauaUL;sol ;6oulsowlxl;(uL ;  sL(Xa lu ;lxluXsanbsxlUbs 
 w( s  aXmslc%®xamauamumslal ;)lmUu xlml;sXslama o(sa9®®xUftU
oulsowlxlmLmaxauUo;xamt L;n;n uusau Xs 6nlsbmauaulXXlsslamnlsblmsXk mao;
xlml;sXslam) masawllsL;sol ;Cx ;s ;sD;ban sbsoulsowlxn;masxosU ml)
amt L;sbsX  lk ;lmUu lmi slama ®)8xUftUa oulsowlx k ua( mmslcoulsowlx
X ;(am; 6nb X ;mslcoulsowlxmslal ;n X mas s s lmsb mlxu;6nblbX  lk 9®
aX9®®xUftUC
mk ;slUsaXXaboX D)

X ( s ca; sawlauaUL;soLsX s LmaxauUo;xamt L;nlsboulsowlx
lmsXk mao;uLsa; ;a ®69®aXW®xUftUn  tuL aX+am; oslk n  t;)s9®xUftU6ma
 kl m a sX sx mscX us sawllsLn;a; Xk  w (s aXsb  w( s (bXxauaUlu    s
amnbls uaa uumuLx(baLs aoms;C;xuu X ; o saua;;a  uu;D0masawlauaUlu
    s;amsb b xsauaUluaXuaalab xl;sXL(Xx s X; kuos n X a; Xk )sW®
xUftUa; 6snamlxu;(X ; ms nlsb(aaXU m Xuulmlu;lUm;CbL(asb Xxl6bL(aslklsLm
(Xa;sXslamD)b   xu ;ban sb ; ;Lx(sax;;sXslmUamL9Wmn;(X xsoX uL
;Xl l amL%® s Xsb sblXxlml;sXslama oulsowlx6nb X ;sb xu (X ; ms nlsb
sb ; ulmlu;lUm; s Xsb  aoXsblm o;lammX ak X nlsb;Lx(saxslsX sx ms)




mX uslamsasb (XlxXLslklsLa oulsowlx6uLx(bal (u slamn;lmo lmsb ;(u  mm
uLx(bma ;sasbsb 9®xUftUmW®xUftUa; ;)
m;ax mlxu;6 X ; lmsbLxo;m
;(u  mn lUbs;n;a; Xk )	l;sa(sbauaUlu wxlmslam;ban ;(u  mmuLx(bma 
sXa(bL6xaX (Xamaom ssb W®xUftUa; )lslamubmU ;   slmUsb 
b xsauLx(ba(al slax(Xsx msC%®c w(X ;;lmU uu;Dn X  aomlmsb uomU;6ulk X6tlm L;6
X mu;Cu otaLsa;l;6 wsXx ouuXLb xsa(al ;l;Dmam xXXanClmX ; 
xL ualf XLsbXalXslaD)
ml   X msaXUm;a ;ax mlxu;6xmLlxxsoX  uu;n X a; Xk 
nlsblmsb k ;; u;)

	 (sllm uxxslamn; xam;sXs ssb 9®xUftUa; lm9a Emlxu;)	l;sa(sbauaUL
 xam;sXs puo;s Xea b (slu ;lam;3xlmlxu;lmUu  uum Xa;l;6;ulUbsuLslks o(   X
 uu;mxlmlxulm uxxsaXLbmU ;)
s;baou mas sbssb c uu (u slamlmsb 
( Xl(b Xuuaa;n uu;lmam xXXann;(XslouXuLxXt lmsbl;mlxu0o(amm Xa(;L6
X oslama c uu;n;SSJlmsb am xXXan6nb X ;sbl;kuo X b ((Xawlxs uLEIJ
lmsb asb Xxamt L;sX s nlsb9®xUftU)ssb W®xUftUa; ;lmUu c uum Xa;l;n;xlmlxu
Cm/%DaX;ulUbsCm/%D aX+a sb Examt L;mslkslama sb o(   X uu;n;;ulUbsCm/%DaX
xa Xs Cm/9Dlm8aosa sb ; +mlxu;)ax lm uxxsaXLbmU ;n X mas )

(a;;lu bL(asb ;l;sasb a; Xk xlmlxub (slu ;lam;l;sb X ;oXU m a (sbaU m;
o; Lsb lxxoma;o((X ;; ;ss a sb mlxu);sb ulk X mFLx slklsl ;C6D
n X masxal l m;lm oulsowlxlmasXa;;cX snlsbsb ulk Xlmsb sl;;o cXa;;
X slklsL;;L6sbl; lmlmUn;am;l X mamck X;     s); amsb ; sawlauaUL
;sol ;lmmamcboxm(Xlxs ;6sb ulk Xaou sXU saXUmm;( luss mslam;baou 
(lsab (slxamlsaXlmU6msa;oulmlulm  slam;6nblbmlx(sb (sl(Xx s X;;ob
;bXamlb (slsl;)

OBCBO D ONSF CRN OBRU3BF
as 688(sl ms;nlsbX u(; aXX  XsaXLbk   msX s lm lX;sclmboxma; 
 ;uslam;soLC(Xasaau%®c®G®8D)sl ms;X  lk  lsb Xam n  tuLlm o;lama ;lmUu U ms
oulsowlx aX+a; ;sWl   X msa; u k u;C(Xs
DaXn  tuLIca; X Ulx msam a; 
u k uC(Xs

D)Xs

o; mlmlslua; a 9W®xU auuan LGa; ;a +W®xUCsasua; 88®®
xUD)

AKFNEBC RBG
 s Xlmi slama oulsowlxnlsb9W®xUa;  auuan L; k mn  tuLlmi slamnlsb+W®xU6
X ;ous;;oUU ;s mamculm X(bXxatlm sl;nlsba; C+W®xUk;9W®xUDmslx Cn  t+k;
n  tID3xaX sbm(Xa(aXslamulmX ; a xwm:o sau Xm  X ; )b 
kauox a l;sXloslams;s L;ss n;;xuuCzWD6((Xawlxs uL Tousauaakauox )
b ; mamculm X(bXxatlm sl;xL  w(ulm LlmlmUa oulsowlxsals;sXU s6nlsb
uXU ax(am msa sXU scx ls  ulxlmslam s Xsb  lX;sa; sbsl; X ;  s X
;o; To mslm o;lam;o saX oslamlmsb kluu sXU s)	an k X6ulxls s aX ba; 
u k uabaXsmam;l Xu kXllulsLlm; ulm (sl msbXs Xl;sl;6(XslouXuLlms Xx;a 
soxaXoX m6xt  lXxamuo;lam;l  lous)

b ulm Xx m; Xoxam msXslamcslx ;(Xa lu  s Xsb  lX;s6sb  aoXsbmsb  lUbsblm o;lam
a oulsowlxX (X ; ms lmlUoX 9);oxxXLa mamcax(Xsx msu(Xx s X; s X
sb  lX;s6sb  aoXsbmsb  lUbsblm o;lama oulsowlxX (X ; ms lmu %)


BTUK 0iBC KF CG KUFNC CRKRBNClRBF GSKN BO  R KRA  BKGRtRA  NUKRACRA  BTARA
BC UGBNCN UOBRU3BF





C8(sl ms;0SJD)s XoUcX us ;6l) )aoXXlmUxaX sbmam n  t s Xsb u;slm o;lama 
oulsowlx6am;l;s  ;; msluuLa lm  slam;Cm/9%Dmm osXa( mlCm/+D)

n msLcsbX  lm o;lamcX us X slam;C
;Dn X X (aXs lm%®(sl ms;69Ea sb xUX %
mGC8lm(Xs
6+lm(Xs

D6UX 8)lws  ma sb ; %8
;aoXX  s Xsb  lX;slm o;lama 
oulsowlx68 s Xsb ; amlm o;lamm+ s X;o; To mslm o;lam;)X 8lm o;lamcX us 
X slam;X TolX lm o;lamlms XXo(slammX ;auk nlsbaos; To u  s X;Lx(saxsl
sX sx ms;ob;aXsla;s Xal6mslbl;sxlm ;6awLU msb X(L6mXambalusaX;lm; a 
Xamba;(;x)

n msLsbX   (l;a ;a XoUcX us (LX wln X X (aXs lm%®(sl ms;0xluCq8S1D aX%®
 (l;a ;mxa Xs C Xax8Ssa+®1D aX8 (l;a ;)	 b ;6bluu;6mo; m;sb ml
n X uuX (aXs ;xlusaxa Xs ;)

l s  mXoUcX us lm  slam;n X X (aXs lmS(sl ms;) ma sb ; h;n X xlusa
xa Xs X ;(lXsaXLsXslm  slam;6b X( ;X oXX m ;aXmu; ;; ;)m UX 8ul;s Xla;l;
n;lUma; ssb slx a sb +sblm o;lam auuan LUX 8Xamba(ouxamXL
;( XUluua;l;%xamsb;us X)m UX 8kXl uun;X (aXs lmam (sl msmX TolX 

sX sx msnlsbLuaklX)masb X(sl msnlsbx lubl;saXLa aXslkuk X (u x msm
;s(bLuaau maXlsl;X  lklmUoulsowlx(X ; ms nlsb%UX + (l;a ;6IrhIttn(
 I; (;l;sb mIh  ttn(nrn(; (;l;nlsb maXlsl;)kauoslamn; kaXu 
 s Xmsllaslsb X(L)uusb ; lm  slam;X ;auk nlsbaos; To u  w (sIh  ttn(nrn(
; (;l;ax(uls nlsb maXlsl;6nblbX ;auk  s Xkuk X (u x ms)

n msL (l;a ;a XoUcX us m osXa( mln X a; Xk lm9W(sl ms;;n uu;%lslamu
; ;a   Xlu m osXa( ml)lUbs (l;a ;C+®J0+lm(Xs
m+lm(Xs

Dn X UX 8
m osXa( mlmG (l;a ;C8WJ08lm(Xs
m+lm(Xs

Dn X UX +)
m(Xs
6uu (l;a ;
osam aoXX nlsblmIL; s Xsb  lX;sa; mX ;auk ;(amsm ao;uL ;(ls amslmoslam
a sb sX sx msnlsboulsowlx)LamsX;s6lm(Xs

6UX 8c+m osXa( mln;a; Xk  s X
sb sblXlm o;lamlm8; ;6 s Xsb GsbaXIsblm o;lamlm8; ;6mus Xlmsb u;ssna; ;)
X sx msnlsbUXmouaLs auamL;slxouslmU saXCcDn;;sXs lm+; ;u lmUsa
X ak XLsamaXxukuo nlsblm9sa8L;)aoX; ;X ;auk ;(amsm ao;uL)

u k m (l;a ;a XoUcX us sbXaxaLsa( mln X X (aXs lm9®(sl ms;am;l;slmUa 9®
UX 9c%m9UX 8)lm a sb  (l;a ;X (aXs aoXX u ;;sbm+Ib s Xsb ;sXsa 
oulsowlxlm o;lam)

XoUcX us (mLsa( mln;X (aXs lm8(sl ms;C9UX 8m%UX + (l;a ;D)aXuua 
sb x6xlusaxa Xs (X c wl;slmU(mLsa( mln;(X ; mss; ulm )uuosam (sl ms ouuL
X ak X )b u;sam n;(X xsoX uLnlsbXnm Xaxsb ;soLo salUma;l;a 
amaxlsms; amXLu ot xl)

lw(sl ms; b w( Xl m am XoUcX us  u ks ulk X mFLx  k ms6Cl) )lmX ; ak X%wlm
uam 6aXfutulm ba;(bs; Xsla5aX TousaWDC;  u 8D)lk aosa sb ; E
 (l;a ;n X UX 8;nb X ;sb Esbn;UX %)aoX (l;a ;aoXX ;aam s Xsb  lX;s
lm o;lam6am aoXX  s Xsb ; amlm o;lam6msb u;sam n;a; Xk  s Xsb +sb
lm o;lamlm(sl msnlsbx lubl;saXLa bXamlxlw b (sa uuouXmbau ;sslulk X
l;aX X)uua sb xn X ;Lx(saxsl6l;aus 6msXm;l ms) lsb XlmX ; u k ua 
lulXolmmaXlx(lX (Xas lm;Lmsb ;l;n X X (aXs ) ak XLn;;(amsm ao;nlsbaos
X oXX m  s X;o; To msoulsowlxlm o;lam)

O piK flp O DR OBD K CarF GUGS R RN K OR RNUOBRU3BF

NANKR
RB CRCUF K
K 



®9c®9
8

®Gc®8
8
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®%c®%
%
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8



®8c®E
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8

a(sl ms;n X  aomsa (a;lslk  aXmslcoulsowlxmslal ;o(sa9%xamsb; s Xsb 
;sXsa sb ;soL)

xamUsb 89W aX x mslam ;68Sn X X (aXs ;; Xlao;k X;  k ms;CD6%8a sb x
 lmU;o;( s sa X us sasb ;soLXoUC;  u +D)
sl;samas sbssb ; %8;
aoXX lm9W(sl ms;)uua sb ; ;X ;auk nlsbaos; To u  w (sIh  ttn(nrn(
(h((C(sl ms®+c®+Dm; a (mLsa( mlo sa; amXLu ot xl aXnblbsb (sl ms
n;(X xsoX uLnlsbXnm Xaxsb ;soL)

O xiKUTlK OR G KBNUGD KG  D CRGOBGRBCT

NANKR
RB CRCUF K

K m

®Wc®9

m o;lamX us X slam
8

®Gc®9
l;s Xla;l;
8

®Gc®9
Xamba(ouxamXL;( XUluua;l;
8

®9c®8
LX wl
%

®+c®+
sX (saau; (;l;
+

®+c®+
s(bLuaau; (;l;ax(uls nlsb maXlsl;
+

®9c®+
 Xlu m osXa( ml
8
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®%c®%
os lm o;lamX slam
8
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®%c®%
mLsa( ml
+
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®8c®+
os lm o;lamX slam
8
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®8c®+
Xl uu
8



®%c®8
 osXa( ml
+



®%c®8
LX wl
9



®8c®E
u ks lk XmFLx ;
8



®8c®E
 osXa( ml9
+



®8c®E
 osXa( ml%
+



®8c®G
LX wl
%



®8c®S
os lm o;lamX slam
8



®+c®W
os lm o;lamX slam
8



®Ec®E
os lm o;lamX slam
8



®8c®I
 osXa( ml
+



®9c®E
mLsa( ml
+



®9c®E
 Xlu m osXa( ml
8
,aXlmUsak8

am a sb  aX x mslam ;b;  mam;l X ;a; culxlslmUsawllsLaXlmUsb 
ioUx msa sb ;soL  sLaxxlss  )b X  aX 6sb xwlxoxsau Xs a; b;mas  m
X b L s)

  Br
 xaUX(bls aXsb (sl ms; mXauu lmsb ;soLn X ; auuan;)b x lmU a sb 88
(sl ms;n;E+L X;CXmU +8cGGD)sl ms;bX  lk 8CXmU 9cIDulm ;a mslm Xsb X(L
(XlaXsa;soL msXL6Ea sb xX  XsaXLsasb lXxa;sX  mssX sx ms)lUbs  m(sl ms;CWWJD
n X (X klao;uLsX s nlsbXlsowlxcamslmlmUsb X(Lssb slx a lmuo;lamlmsasb ;soL)
uu(sl ms;osam (X ; ms nlsbuLx(bma  muXU x ms699C88JDa sb xbklmUoutL
C5WxDuLx(b ma(sbL)n msLam (sl ms;CEIJD(X ; ms nlsb;(u max UuLmWC9WJD


nlsbb (sax UuL) lmuaauLx(baLs aomsn;8E)Gw9®SfCXmU +)8Gc%9+D) lm
b xaUualmm(us u su k u;n X 99)SUfum9®Gw9®Sf6X ;( slk uL)blXs  mC8SJD
(sl ms;bm
Ukuo qEUf)

ulmluX ;(am; n;; amsb Xls Xl ;sul;b Lsb slamum X
m;slsos C
Dc
aXtlmUXao(o(s lm%®®ICWD) ;(am; sn X kluu  aX%S(sl ms;69Iaosa %9lm
(Xs
m99aosa 9%lm(Xs

)aax(u s X ;(am; ;n X a; Xk nbs k Xsb abaXs;)
n uk C+9JD(sl ms;n X lm(XsluX ;(am; CDsxamsb+6Wf9Ilm(Xs
6mGf99lm(Xs

)
n;am lXx %xamsb;us XlmIC%IJD(sl ms;68fWlm(Xs
mWfG(sl ms;lm(Xs

)


FFUC    RG
lUml lmsuaauLx(baLs  (u slamn;a; Xk lmuu(sl ms;X  u slmUsb lms m 
lauaUluslklsLa oulsowlx)
msb +ca; (Xsa sb ;soL6uLx(baLs  (u slamn;
xwlxuam n  t s Xsb +sba; a oulsowlxnlsbx lmuLx(baLs aomsa ®)Sw9®Sf
lmabaXs6aXX ;(amlmUsaSGJX uslk bmU 6( X;l;slmUam xamsbus XC;  lUoX %D)
msb 
Ica; (Xsa sb ;soL6sb uLx(baLs aomsmlXn;ombmU os(Xa aomCua; saS®JD
 (u slamn;;o;slm omsluExamsb; s X;sXsa sb X(L)

BTUK fi CONNrFSANrR NUCR


RUB GBCS BONSUORBNCG
ulsowlxb;mas  m kuos lm( lsXl(a(ouslam;6aXlm(X Ummsnaxm)
0op 



	

b sXlunluuoslulF 
 aX;(lm lxUlmUnlsbmnlsbaosamsX;soXlmUsb sXlu aXX u(; ;6
;( X;smXa X amxl;;lamm aXX ; Xb(oX(a; ;am auuanco()
m; ;a (aaX
X slmlm u Xm 6amsX;snluumas o; )

aX(oX(a; ;a sbl;sXlu6sXlu;s  nluuX kl n;smXa X 
;a sb ;(lm mfaXa(sl
m Xk ;0sb  auuanlmUbXs Xl;sl;nluu X aX  aXX ; Xb(oX(a; ;3

9)  mUsba ;Ulssu;(lm %u ;lamlm mslx s X;lmuu;oi s;nbaaslm
;6m
%)  mUsba ;Ulssu;(lm 9c(a;samsX;su ;lamlm mslx s X;mfaXaXlsu9c(a;s
amsX;su ;lamlmxluulx s X;lmsba; ;oi s;nbalslamuuLX  lk Uaulmlox
amsX;s)

;lmUu X  XnluuX kl nsb 
 aXX ; Xb(oX(a; ;mnluu lm ( m msa sb sXlu)b 
X  Xnluuu;a ulm sasb slx ; To m ;a sb ;m;)
Coho(t A - 75 m  IV (N=4)
Coho(t B - 200 m  IV (N=2)
Coho(t C - 510 m  IV (N=3)
Coho(t D - 1050 m  IV (N=3)
Coho(t E - 1650 m  IV (N=5)
Pa(t II - 3300 m  IV (N=11)
0
10
20
30
40
50
60
70
80
90
Time f(om the fi()t infu)ion (month))
0
1
2
3
4
5
6


0ox 	
uu;oi s;nba lusaulmluuLX ;(amLLWlmsb s XalX sx msb; nluu 
X axx m  aX(u;x wbmU ;( X;smXa X ) m  lluX ;(am; l;U m XuuL
am;l X mlx(Xak x mslmsb ;( l l  llsC;Dsbsu sasb ba;(lsulFslam) ( mlmUam
sba; ;( l l  lls;6sb Xls XlsbsX Xaoslm uLo; sabm;	a(tlm;salmls sX sx ms
X ;(am; C;DlmxasaX6; m;aXL6osamaxlmkl;ou omslamX 3
9) mlx(Xak x mslm;sX mUsbLsb asaX ; Xbaomlu;sX mUsb;u Lsu ;s9 ouu
(almslmsu ;ssnal;aus xo;u ;a su ;sam ulx6aX
%) mlmX ; a snaL usomlmU aXtomls;lmsu ;sam    s ulx)
8) 
x(Xak x mslman umfaXu X omslam Xaxlmamslm m sasu ;s(Xslu
kauomsXLamsXau)
+) mlx(Xak x mslmkl;ouolsLo;lmU ;l m uu m Tolku msa V%ulm ;)

 ;oi s;amasX TolX  ;uslamsa(u;x wbmU  o; sb L ou luusb ulmluXls Xl
ak 6m
xL ( X aXx saam lXxX ;auoslama sb lm uxxsaXLu ;lamC;Dax(X sa
xl;;lam
); amsb 
masb Xulmlu saX;6sb sX slmU(bL;llmxL(Xa  sa
l;bXU sb ;oi sbax aXbmU sb (umsa ;us lxxoma;o((X ;;lamsa(u;x wbmU 
 aXamslmo sX sx msa sb os  w Xslam)
  aX l;bXU  Xaxsb ba;(lsu6sb ;oi snluu;b ou  aX auuano(lmsb ulml aX
sb S®m9I®Lkl;ls;)lmlmU;L
sbsxLlm uo m  ;uslamsa(u;x wbmU 
sL(luuLlmuo  ws m;lama  mbm x ms6lmkauk x msa m nX ;a sb m Xkao;;L;s xaXm
lmX ; lmsb X a %bL( Xlms m;lsL)	l;saXluuLxamUsb f(sl ms;sX s s
abm;	a(tlm;6((Xawlxs uLW®Ja f(sl ms;lx(Xak  XaxX u(; nlsb;s Xal;
uam )b asb XW®JX TolX  ;us X nlsb(u;x wbmU )

u;xwbmU X sx msb; 
baou;oi s;masx  sak ulmluXls Xlsa l;bXU bax 6 ;uslamsasX sx msnlsb
(u;x wbmU l;;smXa X )

b (u;x wbmU sX sx ms(b;  Ulm;ssb  ma sb s XalX sx msb; mnluu
u;so(sa9+L;)oXlmUsb u;xwbmU X sx msb; 6;oi s;nluuom XUa9)®r9)W
kauox ;a (u;x wbmU  k XLasb XLaXlmUsa;smXa X )ssb  ma sbl;(b; 6
; am
xL ( X aXx saam lXxX ;auoslama sb u ;lam)
 mL oXsb Xos 
lxxoma;o((X ;;lk sX sx ms aXsb os  uX l;X TolX m(Xakl aXlmUsa
;smXa X 6sb ;oi snluuamslmo sa  auuan  aX;  sLl;;o ;6ossb ulmlu   lL
snluumas lmuo lmsb ;ssl;slumuL;l;)	l;saXluuLxamUf(sl ms;
sX s ssb abm;	a(tlm;	a;(lsu6((Xawlxs uLSWJa f(sl ms;nbaax(u s 
(u;x wbmU X l;bXU  auuanlmUax(u slama sb (u;x wbmU )

u;x wbmU nluuult uLu XX xlmlmUlXouslmUoulsowlx)	an k X6Lsb slx (u;x
 wbmU l;lmlsls amLEa ba;(lsulFslam6WL; s Xsb XoUlm o;lam6xa;s6l masuu6a sb 
lXouslmU uu;nluuuX Lbk   m ulxlms ;;banmlmlUoX %)usbaoUbsb X l;ma
 w( Xlx msu(bXxatlm slslm(sl ms;nbaom XUa(u;x wbmU WL; s X
X  lklmUoulsowlx6 w( Xl m nlsbXlsowlx6;lxluX uu (u slmUU ms6o; lmsbl;
(sl ms(a(ouslam;oUU ;s;sbsos  uu (u slam(XlaXsa(u;x wbmU l;masbXx ouos
sb     sa XlsowlxxLn Xa  ;aam Xsbmlm(sl ms;nlsbaos(u;x wbmU )bl;xL 
o sa    s;a Xlsowlxaos;l a sb lXouslamC )U)6am xXXanDsbsmaXxuuLu ;saEcI
xamsb;a lXousaXL uu (u slam);nlsbXlsowlx6(u;x wbmU xLu;a;baXs msb 
oXslama lXousaXL uu (u slamo saoulsowlxlm(sl ms;)b ;     s;nluu 
xamlsaX LxamsbuL uuaoms;)





f 

b ak Xuuai slk l;sa;; ;;sb ;  sLa oulsowlx;camsb X(Lsa;s Xal; aX
sX sx msa os a(slm oXlsl;mfaXsXm;k X; xL ulsl;lmm)
fo0 


a;; ;;;  sLa os  uu (u slamlm;oi s;nlsbos X u(; a a(slm oXlsl;aX
sXm;k X; xL ulsl;nbaX sX s nlsboulsowlxH;s Xal; UlmmlmUama; 
xlml;sXslamm mlmUnlsbX (u slama lXouslmU uu;)
fof 

g
a s Xxlm sb  uu (u slam(bXxatlm sl;a oulsowlxlmsb (sl ms
(a(ouslamnlsbxamsbuL uuaoms;)
•
a s Xxlm sb (bXxatlm sl;a oulsowlxlm(sl ms;)
g
a s Xxlm sb  X To mLa k X;  k ms;nlsboulsowlxlmsb (sl ms
(a(ouslam)
•
a auuanulmlu m(alms; aX(X ulxlmXL kl m a    lL)ulmluaosax ;nluu 
xamlsaX  aX   lLo;lmUsbX   omslamum oXauaUls ;s;6sb w(m l;lulsL
sso;u CD6lx %Wcaasutm	lUbamsX;sl;ouolsLC	DoXlmU
xl;;lamsasb ba;(lsumsna auuano(kl;ls;6S®L;mExamsb; s X
ba;(lsulFslam)lslamuulmlu m(alms;nluulmuo 3
•

u ;lam;lF 
•
ox Xa L;lmba;(lsu
•
 TolX x ms aX(u;x wbmU X ;o sb X(L
g
a;; ;; aXsb     sa lxxomaU mllsLamsb (bXxatlm sl;6(bXxaLmxl;6
m;  sLa oulsowlx)








p 
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oi s; ulUlu  aX mXauux msxo;sx  suua sb  auuanlmUXls Xl3
9) u mnluulmUsa(Xakl nXlss mlm aXx am; ms)
%) 9Ic9®®L X;a U )
8)  nos a(slm oXlsl;mfaXsXm;k X; xL ulsl;)m nulmlu k msl;  lm ;
ulmluuL;lUml lmsm oXauaUl  llsC;Dam(bL;lu wx6masssXlosu samasb Xl; ; 
(Xa ;;6nblbl;l   X ms Xax; ulm m oXauaUlu wx6mssXlosu sau ;lamlmsb 
;(lmuaX6a(slm Xk aXXlm;s x) n;Lx(sax;xo;s X (aXs nlsblm9®L;a 
am; s)
+) 	lUbuL;o;( s aXam lXx lUma;l;a aXlmUsasb %®®EX kl;lam;a sb 
lmU XbotlUma;slXls Xl aXClmU Xbot6%®®ED6aX+(a;lslk ( Xsb 
ol ulm ;)aX6;oi s;xo;sbk sna;auos Xls Xl3
) a(slm oXlsl;
) xL ulsl;
Csu ;ssnaa sbX  ;o((aXslk Xls Xl3
) (X ; m a amslUoao;;(lmuaX
u ;lam ws mlmUak XsbX  aXxaX 
k Xs Xu; Ux ms;6
) 
Xls Xl;sl; LlmUsb X kl; amulUma;slXls Xl aX
2auxm6%®99.
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aX6;oi s;xo;sbk uamUlsolmuuL ws m;lk sXm;k X; xL ulsl;CD
X oXX msl;aus a(slm oXlsl;C
Dflus Xua(slm oXlsl;CD6aXa(sla;(lmu
xousl(u ;u Xa;l;CDsbsl;+mslaL(a;lslk 
W)
b  uuaomsxo;s maXxuCWc%®Ja sasuuLx(baLs ;Dlm;oi s;nbabk mas
X  lk masb X uu (u slmUsb X(Llmsb (;sL X)aXsba; am uu (u slmU
sb X(Lnlsblmsb (;sL X6 uuaomsa su ;s®)WJa sasuuLx(baLs ;l;m  ;;XL)
E)
  xu ;oi sl; ulUlu sa ms Xsb sXlul ;b l;3
) as(X UmmsaXmoX;lmU0
)  mamcblu XlmU(as msluCl) )nax mnbabk bbL;s X saxL6X (a;sc
x ma(o;u6nblbl;  lm ;5%L X;nlsbaosx m; ;aX6lm  xu ;oi s;nba
bk   m(a;scx ma(o;u aXq%L X;6xo;s am lXx nlsbauulu slxouslmU
	aXxam C	Dm ;sXlauu k u;D6bk asbakXl ;;oXUluuLX xak aXbk 
oXX msaox ms souulUslamD

 bluc XlmU(as msluCl) )nax mnlsb omslamuakXl ;mmaaox ms 
lx(lXx msa aklosuaXos Xlm  omslamsbsnaouo; ;s XlulsLD)bl;s UaXL
lmuo ;nax mnlsbaulUax maXXba C k m; k X D6nax mnbaX ( Xlx ma(o;u
aXbk io;s Uomsax m;sXos )ax ma bluc XlmU(as msluxo;sbk 
m Uslk ; Xox(X UmmLs ;ss;X  mlmUmUX  ;saam a sb  auuanlmU3
9) ax(u s ;slm m  Xaxlms XaoX;  aXsb ( Xla Xaxam; mslmsasb sXlu
omsluExamsb; s Xsb u;sa; a lmk ;slUslamu(Xaos0aX6


%) am;l;s msmaXX so; a am a sb  auuanlmU (su x sba;a lXsb
amsXau aXsb ( Xla Xaxam; mslmsasb sXluomsluExamsb; s Xsb u;s
a; a lmk ;slUslamu(Xaos3
) XuamsX (slk ;C lsb Xaxlm aX(XaU ;s Xam amuLD
) 
mi su (XaU ;s Xam 
)  kamaXU ;sX ulx(ums;
) ;sXaU mlkUlmuXlmU
 ) amsX (slk (sb ;
 )

msXos Xlm  kl C
DaXlmsXos Xlm ;L;s xC
Dnlsbaox ms 
 luoX Xs a q9J( XL X
U) u (Xsm X;s XlulFslamCk; saxLnlsbaox msslama Faa;( XxlD
(XlaXsasb   xu ;oi sh; msXLlmsasb sXlu0sbl;xu xo;s sb ;au 
(Xsm X aXsb ;oi s
b) aou XXl Xx sba3amaxmmauo;lk (Cl(bXUxaX
 Xklufkous(;DnlsbkUlmu;( XxlluU ms
C axfU uf luxfX xf;o((a;lsaXLD)

3OUGBNCKBR KB
oi s;x  slmUmLa sb  auuanlmUXls XlX CNR ulUlu mmmas mXauulmsb sXlu3
9) oXX ms kl m aXtmanmbl;saXLa ulmluuL;lUml lmslm  slamlmuolmU3
) bXamlaXamUalmUslk lm  slao;l; ; X TolXlmUuamUs Xx;L;s xlsX sx ms
;ob;6osmasulxls sa36bXamlX mulm  slam6bXamlb ;slm  slamnlsb
Xambl s;l;6so Xoua;l;6aXslk b (slsl;)
) X klao;; Xlao;a((aXsoml;slaXsL(lulm  slam;)
) 	l;saXLa (a;lslk ; XauaUL aXb (slsl;)
) XlaXbl;saXL6aX;o;(llam6a so Xoua;l;CD)
 ) 	l;saXLa (a;lslk ; XauaUL aX	
)
%) 	l;saXLa ulmluuL;lUml lmssXoxC )U)sXoxslXlmlmioXL6 X Xuamso;lam6
;(lmuaXax(X ;;lamD
8) ;saXoXX msbl;saXLa x luuL;lUml lmsk X;     s;ClmuolmUuu XUlX slam;D
 Xax3
) aXsla;s Xal;
) l(b mbLXxlm 
) oXlm aXxao; fboxmblx Xlmslal ;
+) ;saXoXX msxulUmmL6 w (s aX
)  XkluXlmaxsU 9aXu ;;
) amclmk;lk ;u uum;Toxao; uu;tlmXlmax
) m XlUma; ;nlsboXslama ax(u s X ;(am; CX xl;;lamD5WL X;
ABGRNKrN A FRNONTBFOBTCCr 3OU GGUL R KNFSKRBBSRBNCt
K TKO GGN K GSNCG o


W) ;auos m osXa(bluaomsu ;;sbm9®®®fxlXauls Xtr(us u saomsu ;;sbm
W®6®®®fxlXauls Xa uaa)
E) lUml lmsamoXX ms6omamsXauu x luamlslamlmuolmU6osmasulxls sa6Xl6
X mu6b (sl6b xsauaUlu6U;sXalms ;slmu6 maXlm 6lxxoma  ll mL;LmXax 6
(ouxamXL6 X Xu6(;LblsXl6aXm oXauaUlul; ; nblbaou   ssb ;oi sh;
;  sL6lx(lXsb ;oi sh;X ulu (Xsll(slamlmsb sXlu6lx(lXsb  kuoslama 
 m(alms;6aXm  ;;lss sb o; a x lslammasuuan Lsb (Xasaau6; s Xxlm 
Lsb 
a sb sXlu)
G) ; a mlmk ;slUslamuXoUaXasb X w( Xlx msusb X(L aXamlslamasb Xsbm
nlsblm+n  t;6W(bXxatlm slbu culk ;aXoXslama lauaUlu    s
Cnblb k Xl;uamU XD(XlaXsa;X  mlmU)
I) oXX ms(Xsll(slamlmmLasb Xlms Xk mslamuulmlusXlu)Xsll(slamlmmamc
lms Xk mslamusXluX TolX ;((Xakua sb (XasaauLlmk ;slUsaX)
S) oi s;nbaX amoXX msuLX  lklmUmLasb Xlmk ;slUslamuU ms;6aXbk 
(Xsll(s lmmlms Xk mslamuulmlusXlunlsblmsb u;s%9L;6aX;oi s;nbabk 
  mklms nlsbulk klm q%xamsb;(XlaXsasXlulmuo;lam)
9®) o; sb X l;momtmanmos(as msluXl;t aXk X;  k ms;lmmoX;lmUlm ms;
; amXLsasX sx msa sb xasb XnlsboulsowlxX ;s   lmU;baou 
l;amslmo l sb xasb Xl; mXauu )




x 


xo0 


aX Ul;s X;oi s6sb  auuanlmUaox ms;;baou ax(u s Lsb X ; XbaaXlmsaX
m;lUm Llb u kL66b)3

•
lUm ulUllulsLX  mlmUaXt;b  s
•
 Ul;sXslamaXx

X) kLnluusb mk Xl L ulUllulsL)aax(u s sb X Ul;sXslam(Xa ;;6X) kLnluu3

•
;;lUm;oi ssXlumox X
•
 Ul;s Xsb ;oi samsb sXlu
•
sXssb lm o;lama ;( Xsb (Xasaau

 s Xsb  lX;ssnaC%D;oi s;X  mXauu max(u s lm o;lamnlsbsXluXoUCDaX s X
sb  lX;s;lwxamsb;6nblb k Xl; lX;s6sb nluux  ssaX kl n;  sL)a oXsb X;oi s;
xL  mXauu lmsasb sXluomslusb b;X kl n sb ;soLsm;oxlss sb lX
amuo;lamsasb (am;aXm
)b nluulm aXxsb (am;aXsbssb ;soLxL(Xa  
; auuan;6saX o sb a; 6aXsas Xxlms sb ;soLo sa;  sLam Xm;;mas  uan)

 Xxls;sb Xlusaamslmo 


 sb ( Xxls;sb ;soLsaamslmo 6mlslamusbX  C8D;oi s;nluu  mXauu m
lm o; nlsbsXluXoUCD)(amax(u slama sb lm o;lama sXluXoUlmsasb ; lslamu
;oi s;6sb nluux  sUlmsaX kl nsb ;  sLs Xaxsb ; sbX  ;oi s;msb 
oxouslk ;  sL Xaxsbl;sXlu)b nluulm aXxsb (am;aXa mL;  sLam Xm;)

 Xxlms ;Xlu

b (am;aXCX) kLDxLbuu mU sbl; l;lam;( Xsb bXs X)	an k X6ma;oi s
xL  mXauu lmsasb sXluoXlmUsb buu mU )



J 
Jo0 



lk msb ; k XlsLmsb am; To m ;a X u(; lm6o; a mslk sX sx msl;am;l X 
xmsaXL)b (as mslua oXX msuLoslulF XoU;ms bmlTo ;saX o sb lm uxxslamlm
b;  m ;sul;b (XlxXluLsbXaoUb w( Xsam; m;o;m;xuua( mu um
X sXa;( slk ;sol ;)

X sx msnluu xlml;s X lmmlm(sl msba;(lsu; sslmUm;auos m osXa(bluaomsxo;s
 59®®®fOm(us u saomsxo;s 5W®6®®®fO  aX lm o;lmU)

UB OBC G NKFBCBGRKRBNCN OBRU3BF
•
Ittei(IrItigoulsowlxnluu xlml;s X ;mlmsXk mao;lm o;lam)
•
as msluXoU
ms Xslam;3aXoUlms Xslam;bk   mX (aXs sas )
o rCeIti(guu;oi s;X  lklmUmlm o;lama xo;s (X cx ls 
((Xawlxs uL8®xlmos ;(XlaXsasb a; a oulsowlxnlsbmmslbl;sxlm 
Cl(b mbLXxlm %WcW®xUaX Tolku msDmaXu sxlma(b mEW®xUCaX
 Tolku msD)
f;oi s;nluu Ulk mmlm o;lama +W®xUfLa ak X aoXC+DbaoX;
am; oslk uLamsb  lX;sLnblu ssb abm;	a(tlm;	a;(lsu)

Jof 







almk ;slUslamuaXaxx XluU ms;aXsb X(l ;asb Xsbmsba;  ;Xl  uanxL 
xlml;s X nlsbsb lms mssasX ssb ;oi sQ;os X u(; )
a;s Xal;xL xlml;s X aos;l a (XasaauX TolX x ms; aXos sX sx ms;aosulm )

C UGBNC RBNCG.BRAUOBRU3BFi
m o;lamX us X slam;bk   m X To msuLX (aXs 
nlsboulsowlx)uu;oi s;sX s nlsboulsowlxX TolX (X cx lslam((Xawlxs uL8®
xlmos ;(XlaXsasb a; a oulsowlxnlsbmmslbl;sxlm Cl(b mbLXxlm %WcW®xUaX
 Tolku msDmaXu sxlma(b mEW®xU)Lx(saxsllm o;lamX slam;6 ;(ls (X c
x lslam6xL sX s ssb l;X slama sb sX slmU(bL;llm6lmuolmUosmasulxls sa3
lslamumslbl;sxlm ;6awLU mmXambalusaX;)

Lx(saxslsX sx ms aXm oXa(sblaXxo;ouX(lmmxo;u ;(;x;xL sX s o;lmU
amaxlsmsx lslam;( X;smXa X )

Jop 
	

msb ; m a sX sx ms uL;o sak X;  k msC;D6sX sx msnluu UlmamL9nlsb
mnlsb;s Xal;amL9mamslmo saLW6omu ;;am a sb  auuanlmUXls Xl((ul ;3
•
 uLlmsXm;  Xsasb abm;	a(tlm;	a;(lsu Xaxmaos;l lm;slsoslam)
msb  k mssbs
m(sl mslms X ;s lm(Xsll(slmUlmsb sXlu(X ; ms;nlsbmos X u(; sa
aos;l lm;slsoslam6sb X ;baou ma uLlm UlmmlmUsX sx msnlsb;smXa X 
;s Xalsb X(L)b ;oi sxL mXauulmsbl;sXlumX  lk am a; a oulsowlxam
sb  lX;sLa ba;(lsulFslamssb abm;	a(tlm;	a;(lsul sb sXm;  Xst ;(u 
nlsblmWL;a (X ; msslam)s XalsX sx msnluuamslmo sabm;	a(tlm;sa m;oX 
sasua WL;a ;s Xal;)


•

ms XoXX msluum ;;sbs(X k ms;xlml;sXslama sX sx ms6
•
m (su k X;  k msC;DoXlmUsb lm o;lama ;s Xal;aX6
•
oi s l ;sanlsbXn Xaxsb sXlu6aX
•
 m XuaX;( l lbmU ;lmsb ;oi sQ;amlslamX m Xsb ;oi som (su  aX
 oXsb XsX sx mslmsb ioUx msa sb lmk ;slUsaX)

b X ;am aXsXluX xakumsb s sb ;oi sn;X xak xo;s aox ms lmsb ; 
 (aXsaXx)oi s;nbal;amslmo sb X(Lo samk X;  k msnluu  auuan omslu
X ;auoslamaX;slulFslama sb k X;  k ms)

Jox 

 s Xl;bXU  Xaxsb ba;(lsu6;oi s;nluu  auuan ;maos(sl msulmluuLsL;S®m
9I®)
mlslam6;oi s;nluu xamlsaX xamsbuL aX uuaoms; aX;uamU;lsst ; aX
 uu;saX (u s saxlmlxoxa ®)WJ aX(sl ms;nbanluuamslmo sa sX s nlsbc uu
 (u slmUU ms; aX(X k mslk X 6aXlmUsa;smXa X 6aXsaxlmlxoxa WJ aX
(sl ms;nbanluuo; asb X(X k mslk ;sXs Ul ;)aXxa;s;oi s;6sb oXslama c uu (u slam
nlsbl;o(saSxamsb;)oi s;X xak  Xaxsb sXlu aXom (su k X;  k msC;Dnluu
  auuan omsluX ;auoslamaX;slulFslama sb k X;  k ms)
mlslam6;oi s;nluu 
b t Lax(u s uaaaomsnlsbl   X mslumax(u s x saul(Xa lu  aX kl m a 
sawllsLsaasb X uu;C )U)6m osXa(blu;DaXaXUm;;ob;tlm LaXulk X omslam)




V 
v



;lmUu a; a +W®xUa oulsowlxnluu xlml;s X om Xsb lX slama sb Xlml(u

mk ;slUsaX6X)lb u kLnblu sb ;oi sl;lmsb ba;(lsu)
sl;X TolX sbssb ;auos 
m osXa(bluaoms 59®®®fOmsb (us u saoms 5W®6®®®O  aX sb lm o;lam)
 sb ulk X
 mFLx ;CmfaXDX 5Wslx ;sb o(( Xulxlsa maXxuCDa sb maXxuXmU ssb 
abm	a(tlm;x luuaXsaXLaXl sb m osXa(bluaomsm(us u s;aoms;X  uan
 (su u k u;; ;Xl 6sb a; a oulsowlxnluu b u aXo(sa+IbaoX;omslusb 
uaXsaXLkuo ;X soXmsanlsblm (su XmU )
 uuu;ak amasX soXmsanlsblm
 (su XmU nlsblm+IbaoX;6sb ;oi snluumasX  lk sb oulsowlxlm o;lammnluu 
nlsbXnm Xaxsb ;soL)





P 

lk msb ; k XlsLmsb am; To m ;a X u(; lm6o; a mslk sX sx msl;
am;l X xmsaXL)b (as mslua oXX msuLoslulF XoU;ms bmlTo ;saX o sb 
lm uxxslamlmb;  m ;sul;b (XlxXluLsbXaoUb w( Xsam; m;o;m;xuua( m
u umX sXa;( slk ;sol ;)

bl;l;b; 96omulm ;  sLsXlulmf;oi s;lmnblb;oi s;nluuX  lk am 
C9Dlm o;lama +W®xUa lmsXk mao;oulsowlxssb am; sa m w Xslamlmlslam
sa;smXa X sX sx msnlsbluLlmsXk mao;x sbLu(X ml;auam s9®®®xU aX lk L;)

b sXlu(b; ;moXslam;6;n uu;;smXa X sX sx msm
;X ;banmlmsb 
su  uan)aXsba; nbaax(u s sb sXlu6lsl;ax(Xl; a +(as mslu(b; ;3X  m6s Xal
X sx ms6u;xwbmU Cl m  ;;XLDX sx msmauuanc()


u 93ulsowlxlmXlub; ;mlxlmU;a X sx ms;f
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-/nAsAfeo7eAtstMnLe:giroL/sAftitsL


n*Aseo7yLsthfig
-/nAsAfeo7eAtstM
n*tMhTiAehpAn7TAseo7yLsthfig
2Lhotit*AE7iLp7nAs7eAts
  7TeLfeAs*
1157fAs/AE7eL/Tgfe7s/7o/tME7oL115MtooLfL7oE:rhortfLf

K  CBCTAG 

b (oX(a; a sb X  mlmUb; l;sa;; ;;;oi s ulUllulsL)bl;(Xa ;;lmuo ;m

;mC;smXa X Dsal msl LamsX;s mbmlmUu ;lamC;Dlmsb a(slm Xk mfaX;(lmu
aX)

oi s;xo;sbk lXouslmU uu;sa mXauulmsb sXlumX  lk oulsowlxsb X(L)aX
sba; nbabk masX  lk  uu (u slmUx lslam;lmsb (;s9%xamsb;CXlsowlx6
a soxox6aX ulFox6oulsowlxD6maXxu uuaomsa Wc%®Ja sasuuLx(baLs ;xo;s
 (X ; mslmsb lXouslam6am lXx Lulxls  uanLsax sXL(m ua 86+69Sm
%®)aXsba; nbabk X  lk  uu (u slmUx lslamlmsb (;s9%xamsb;6xlmlxox
a ®)WJa sasuuLx(baLs ;xo;s  uu;)b naXtlmUbL(asb ;l;l;sbsnb m;oi sb;m
os sst auuanlmU(X k mslk sb X(Lnlsb uu (u slmUU ms;6sb X xlmlmUaXX soXmlmU
c uu;X k XLUUX ;;lk mxLsuLF sb sst)
R KNBK RF CRAG 
	lUba; C9®®®xUDlmsXk mao;x sbLu(X ml;auam nlsb Ulk msauu;oi s;nlsb
c
am lXx slk u ;lam;sam; sa sb sstaXlmUsa;smXa X )oXlmUsb  lX;sLa 
;s XalsX sx msaX; XuL;(a;;lu lmsb ;s XalsX sx msaoX; 6+W®xUa lmsXk mao;
oulsowlxnluu xlml;s X sauu;oi s;)


  aXsnluu  ao; amUlklmUsb oulsowlx; XuLlmsb ;s XalsX sx ms(Xa ;;;
(a;;lu )
 ;oi sh;xl;;lamaXsXm;  Xsasb abm;	a(tlm;	a;(lsul; uL 6;smXa 
X sb X(Lnlsb;s Xal;nluu Ulm;;aam;(a;;lu )b ;oi sxL mXauulmsbl;sXlum
X  lk oulsowlxamsb  lX;sLa ba;(lsulFslamssb abm;	a(tlm;	a;(lsul sb sXm;  X
st ;(u nlsblmsb s XalX sx msb; )
XlaXsasb lm o;lam6ax(u s  uuaomsnlsbl   X mslumax(u s x saul(m u;X  mlmU
 aXmaXxulsl ;lmm osXa(bluaoms6(us u saomsmulk X mFLx ;)
uu;oi s;nba lusaulmluuLX ;(amLLWnluu X axx m  aX(u;x wbmU ;( X
;smXa X ) m  lluX ;(am; l;U m XuuLam;l X mlx(Xak x mslmsb ;( l l
  llsC;Dsbsu sasb ba;(lsulFslam) ( mlmUamsba; ;( l l  lls;6sb Xls XlsbsX 
Xaoslm uLo; sabm;	a(tlm;salmls sX sx msX ;(am; C;DlmxasaX6; m;aXL6osamaxl
mkl;ou omslamX 3
9) mlx(Xak x mslm;sX mUsbLsb asaX ; Xbaomlu;sX mUsb;u Lsu ;s9 ouu
(almslmsu ;ssnal;aus xo;u ;a su ;sam ulx6aX
%) mlmX ; a snaL usomlmU aXtomls;lmsu ;sam    s ulx)
8) 
x(Xak x mslman umfaXu X omslam Xaxlmamslm m sasu ;s(Xslu
kauomsXLamsXau)
+) mlx(Xak x mslmkl;ouolsLo;lmU ;l m uu mbXsa V%ulm ;)

 ;oi s;amasX TolX  ;uslamsa(u;x wbmU  o; sb L ou luusb ulmluXls Xl
ak 6m
xL( X aXx saam lXxX ;auoslama sb lm uxxsaXLu ;lam6aXlmUsa
;smXa X sabm;	a(tlm;); amsb 
masb Xulmlu saX;6sb sX slmU
(bL;llmxL(Xa  sal;bXU sb ;oi sbax aXbmU sb (umsa ;us 
lxxoma;o((X ;;lamsa(u;x wbmU  aXamslmo sX sx msa sb os  w Xslam)
lmlmU;L
sbsxLlm uo m  ;uslamsa(u;x wbmU sL(luuLlmuo  ws m;lama 
 mbm x ms6lmkauk x msa m nX ;a sb m Xkao;;L;s xaXmlmX ; lmsb X a %
bL( Xlms m;lsL)	l;saXluuLxamUsb f;oi s;sX s sabm;	a(tlm;6
((Xawlxs uLW®Ja f;oi s;lx(Xak  XaxX u(; nlsb;s Xal;uam )b 
asb XW®JX TolX  ;us X nlsb(u;x wbmU )
  aX l;bXU  Xaxsb ba;(lsu6sb ;oi snluu ;b ou  aX auuano(lmsb ulmllm
S®m9I®Lkl;ls;)
mlslam6;oi s;nluu ; mssauauu aXxamsbuL9SxamlsaXlmU
omslusb  uuaoms;X (u s saxlmlxoxa ®)WJ aX(sl ms;nbanluuamslmo sa sX s 
nlsbc uu (u slmUU ms; aX(X k mslk X 6aXlmUsa;smXa X 6aXsaxlmlxoxa 
WJ aX(sl ms;nbanluuo; asb X(X k mslk ;sXs Ul ;)b ; X ;ous;nluu X kl n Lsb 
6
X) kL)

OGF3ACT K RF CRAG 

baou;oi s;masx  sak ulmluXls Xlsa l;bXU bax 6 ;uslamsasX sx msnlsb
(u;x wbmU l;;smXa X )

b (u;x wbmU sX sx ms(b;  Ulm;ssb  ma sb s XalX sx msb; mnluu
u;so(sa9+L;)oXlmUsb u;xwbmU X sx msb; 6;oi s;nluuom XUa9)®r9)W
kauox ;a (u;x wbmU  k XLasb XLaXlmUsa;smXa X )ssb  ma sbl;(b; 6
; am
xL ( X aXx saam lXxX ;auoslama sb u ;lam6aXlmUsa;smXa X )
 
mL oXsb Xos lxxoma;o((X ;;lk sX sx ms aXsb os  uX l;X TolX m(Xakl 
aXlmUsa;smXa X 6sb ;oi snluuamslmo sa  auuan  aX;  sLl;;o ;6ossb 
ulmlu   lLsnluumas lmuo lmsb ;ssl;slumuL;l;)	l;saXluuLxamUf


;oi s;sX s ssb abm;	a(tlm;	a;(lsu6((Xawlxs uLSWJa f;oi s;nba
ax(u s (u;x wbmU X l;bXU  auuanlmUax(u slama sb (u;x wbmU )

NOON.lUS

b (XlxXLaosax l;;  sL aXsb oXslama sb ( Xlaa  uu (u slam) amXL   lL
aosax ;nluu ;; ;; s auuano(S®m9I®L; s Xlmlsluba;(lsulFslam aXsb os 
X u(; )
mlslamsasbaXaoUbbl;saXLm(bL;lu wxlmslam6lmuolmUXslmU6kl;ou
 wxlmslammslx nut6X ; Xb
a sb ;(lm nluu ( X aXx sLS®saax(X sa
sb X u(; u ;lam)
mlslam6;oi s;nluu ; mssauauu aXxamsbuL9SxamlsaXlmUomslu
sb  uuaoms;X (u s saxlmlxoxa ®)WJ aX(sl ms;nbanluuamslmo sa sX s nlsbc
 uu (u slmUU ms; aX(X k mslk X 6aXlmUsa;smXa X 6aXsaxlmlxoxa WJ aX
(sl ms;nbanluuo; asb X(X k mslk ;sXs Ul ;)b ; X ;ous;nluu X kl n Lsb 
6X) kL)

BRAK.O

aX;oi s;nbal;amslmo aXnlsbXn Xaxsb sXlu6lmk ;slUsaX;nluuamslmo saxamlsaX
;oi s;nbabk amUalmUm oXauaUl  lls;nblu sb ;oi sX xlm;lmsb ba;(lsu)bl;
lmkauk ;( Xlalm oXauaUl wx;mua; a; XkslamlmauuaXslamnlsbsb sX slmU
(bL;llm)

oi s;omu sasau Xs oulsowlxnluu nlsbXnm Xaxsb sXlu)sau XlulsLl;;o  aXsb 
(oX(a; a nlsbXnlmUsaus Xmslk sX sx msl;  lm ;xa Xs aX; k X ;l c    saX
ax(ulslamX us sasX sx ms6nblbl;om (su sasb ;oi s0aXulmluuL;lUml lms
bmU lmb xsauaUl6b (sl6aXX muuaXsaXL(Xx s X;sbs6lmsb a(lmlama sb 
lmk ;slUsaX6naouX TolX bmU lmsX sx ms)

iItitteh IrilenenrItitrIhIti

ax(u s Xl;  lm ;;oi snbab;ax(u s uua sb ulmluuLm  ;;XL(b; ;a sb 
sXlu6;( X;smXa X 6mb; auuan o(lmsb ulml aXuu auuano(kl;ls;)b 
xwlxoxoXslama (Xsll(slaml;o(saSxamsb; aXxa;s;oi s;)

Um sl ;amm 
xUlmUlmsb Xlu

b sXlunluuoslulF 
 aX;(lm lxUlmUnlsbmnlsbaosamsX;soXlmUsb sXlu aXX u(; ;6
;( X;smXa X m aXX ; Xb(oX(a; ;amS®cL auuanco()
m; ;a (aaXX slmlm 
u Xm 6amsX;snluumas o; )aXlmUsa;smXa X 6
;m;lmsb sXlunluu 
( X aXx ssb lmlslslama sb X u(; )m auuano(6sb 
l;X ; Xb(Xa oX )
aX(oX(a; ;a sbl;sXlu6;smXa X 
;a sb ;(lm nluu X kl n LsXlu;s  0sb 
 auuanlmUbXs Xl;sl;nluu X aX  aXX ; Xb(oX(a; ;3

9)  mUsba ;Ulssu;(lm %u ;lamlm mslx s X;lmuu;oi s;nbaaslm
;6m
%)  mUsba ;Ulssu;(lm 9c(a;samsX;su ;lamlm mslx s X;mfaXaXlsu9c(a;s
amsX;su ;lamlmxluulx s X;lmsba; ;oi s;nbalslamuuLX  lk Uaulmlox
amsX;s)

;lmUu ulm 
m ( m ms  XnluuX kl nsb 
 aXX ; Xb(oX(a; ;)b X  Xnluu 
ulm sasb sX sx ms;;lUmx ms;mslx ; To m ;a sb ;m;)


y 	



yo0 


s


yo0o0 OBRU3BF
e eg
oulsowlx


Ire(g
c99®96cE®8

 ((Itig
 axlmmsblx Xlmslc%®xamauamumslaL

tren Itig
  
mk ;slUsaXXaboX 

ttIti3
XU s;%®mslU mamc uu;


(rhItig
ulsowlxl;U m sluuL mUlm  X blx XlxoXlm fboxm
lX s Ulm;ssb %®mslU m aomamsb ;oX  a 
uLx(baLs ;)ulsowlxl;(uL;sb sL(lu;sXosoX a 
lxxomaUuaoulm;6am;l;slmUa snaUxxCγDb kLblm;msna
t((CκDulUbsblm;ulmt Ll;ou l XlU ;)
sl;ax(a; a 
xoXlm kXlu X UlamC8G)%Ja sasuxlmal;D o; amsaboxm
am;smsX Ulam;)

tonhh g
am msXslama 9®xUfxlm8xC8®xUDm9WxC9W®xUD;lmUu c
o; Uu;;klu;)


Itrg
saXU amlslam;

ulsowlxxo;s ;saX lm; oX ulxls c ;;X s

s x( XsoX XmUlmUH%1fHI1)ulsowlxxo;smas  XaF m)

I I g
slulsLamlslam;

m klua oulsowlxb;  ma( m mfaXluos lsxo;s 

o; lxx ls uL) s Xluoslamlm(auLklmLubuaXl CDlm o;lam
U;6oulsowlxl;;su lm;sslamlslam; aX%+baoX;s%W16m
lmLmxlamlslam;lsl;;su  aXIbaoX;s%W1)


ulsowlxb;;b u cul  a 9Ixamsb;; amkluu ;slulsL
s)

tnIt
ei(IrIti3

msXk mao;

ig
ulsowlxl;(t lmomlsaw ;)bomlsawamslm;3
•
lk 8xaXam 9WxkluC;DamslmlmU9®xUfx;auoslama 
oulsowlx
•

m;sXoslam; aXluoslamlmaloxbuaXl ®)SJ
•
s x( XsoX amsXau;L;s xlmuolmUu  u snlsblm;sXoslam;
 aXo; 


b omlsaw ;amslmlmUsb 8xkluX UXao( LWlmaos X
(tU aw ;6nblbnluu (Xakl sasb ulmlusXlu;ls ;)b omls
aw ;amslmlmUsb 9WxkluX masUXao( lmaos X(tU aw ;
msb Lnluu (Xakl lmlklouuLsasb ulmlusXlu;ls ;)



b amslm Xua;oX ;L;s xa oulsowlxl;L( 
Uu;;kluua; 
L;lulamlF XaxaosLuXo X;sa(( Xmsx( X(Xaa 
(Xas slk (Xlx( sasb m ta sb klu)

a  I g
ulsowlxl;kluu  Xaxb X( osl;

yof 	




g4
yofo0  KrNFFNC70hj
•
ONNCOrFSARBGrGR FBGNK KGi osXa( ml6bXaxaLsa( ml
•
GRKNBCR GRBCOBGNK KGio; 
•
 C KOBGNK KGCFBCBGRKRBNCGBR NCBRBNCGi k X96
m o;lamc us 
 slam;6;sb ml6bluu;
•

C  RBNCGCBC  GRRBNCGiXamblsl;6;a(bXLmUlsl;6blmlsl;6lmo;lsl;6Xub X( ;
•

CD GRBTRBNCGilmX ; 6lmX ; 6lmX ; 
•
 KDNUGGrGR FBGNK KGi	 b 
•
 GSBKRNKrtRANKBCF BGRBCOBGNK KGiaoUb
9P k XPlmuo ;(X   XX s Xx;P(LX wlPmPbL( Xsb XxlP
yofof NFFNC70jCd0hj
•
ONNCOrFSARBGrGR FBGNK KGim xl6mLsa( ml6 Xlu m osXa( ml6
osalxxom b xauLslm xl6XaLslm xl6km;;LmXax 
•
KBBGNK KGiXl uoss X6auXXbLsbxl
•
KCOrKBCRABGNK KGilmmlso;
•
CNKBC BGNK KGibLXalL;s
•
r BGNK KGiamiomslklsl;6Xlxslam X ; 
•
GRKNBCR GRBCOBGNK KGil(  x6lmUlkuu  lmU6Xu(X ;sb ;l;6saxslsl;6
;a(bUlsl;6axlmu(lm6(( Xaxlmu(lm6;sXlou X6am;sl(slam6auaml
(auL(6lk Xslouoxlms ;slmu6lXXb 
•
 C KOBGNK KGCFBCBGRKRBNCGBR NCBRBNCGib ;s(lm6slUo 6
mi slam;ls 
b xaXXbU 6 Xl(b Xu  x
•
	 SRNBOBKrBGNK KGibau ;s;l;6bau L;slsl;os 6lw ulk XlmioXL
•

FFUC GrGR FBGNK KGiXoUbL( X; m;lslklsL6	L(aUxxUuaoulm xl
•

C  RBNCGCBC  GRRBNCGi
m uo mF6omUlm  slam6(( XX ;(lXsaXLsXslm  slam6
Xb lsl;6XLmUlsl;6am;luulsl;6Xaslsl;6slsl;x l6XlmXLsXslm  slam6mu
; ;;6Xamba(ouxamXL;( XUluua;l;6 Xlu lm  slam6l;s Xla;l;6 (sl;bat6
s(bLuaau; (;l;6sX (saau; (;l;6	 (slsl;6 mlsub X( ;6	 X( ;Fa;s X6
•

CLUKrtSNBGNCBCTCSKN UKONFSOBRBNCGiXamUs bmlTo lmXoUo;U 
(Xa ;;6	 lmioXL6a;sa( Xslk b Xml6oosm ao;b xsax
•

CD GRBTRBNCGi lUbs X ; 6 Xox
UlmX ; 6%;soXslam X ; 
•
 RNOBGFCCURKBRBNCBGNK KGil s ;x uulso;lm Tos amsXau6
	L( Xbau ;s Xau xl6	L( XUuL xl6	L( XoXl xl
•
UGUONGE O ROCNCC RBD RBGGU BGNK KGit(lm6o;oua;t u su(lm6
o;u ;(;x;6LuUl6XsbXuUl6 mamlsl;
•
 NSOGFG CBTCtFOBTCCRCUCGS B B gBCOrGRGCSNOrSG4iToxao; uu
Xlmax6;u uuXlmax6 ot xl6 oXa maXlm Xlmaxa sb ;tlm
•
 KDNUGGrGR FBGNK KGiaxmau m 6X ;sb ;l6Lma( k;akUu6
;b xl;sXat 
•
GrABRKBBGNK KGimwl sL6UUX ;;lam6 (X ;;lam6
m;axml
•
 COCUKBCKrBGNK KGi	 xsoXl


•
 SKNURBD GrGR FCK GRBGNK KGi mlsu(Xau(; 6oukL;s
•
 GSBKRNKrtRANKBCF BGRBCOBGNK KGi(l;swl;6bXaslXXlsslam6
Xamba(m oxa(sbL
•
EBCCGUURC NUGRBGGU BGNK KGiXLsb x6XslXl6uu XUl Xxslsl;6
 Xlk;ouX Xxslsl;6tlmb xaXXbU 6	L( XblXa;l;6lUbs;n s;
•
GUOKBGNK KGi	L( Xs m;lam6	L(as m;lam6	as uo;b
yofop CNFFNC7ho0jCd0j
  sLs aXoulsowlxl;amuLkluu  Xaxxlml;sXslamlm88(sl ms;lmsb X  msuL
ax(u s b; 
ulmlusXlulmX u(; mX  XsaXL);;ob6o sa;ssl;slu
ulxlsslam;6maomaxxamk X;  k ms;CaoXXlmUlmV®)9Jmq9Ja (sl ms;Dm 
 ;Xl )
yofox K KBCTOBRU3BF
m sb ulmlusXlu;ls X  lk ;
f((Xakum((Xaku;m
mk ;slUsaXc
mlsls 
C(am;aXD
(X c s Xxlm TomslsLa sXluXoUCDnluu ;bl((  Xaxb X( osl;
sasb 
mk ;slUslamubXxLsabm	a(tlm;)

(amX  l(sa sX sx ms;o((ul ;6sb bXxl;saXsb ((Xa(Xls ( X;ama sb ;ls nluu
ax(u s sb tmanu U x msa X  l(sm; mlstsasb b X( osl;aX ;lUm  m
o(s sb aomslulsL aXx; aXb X( osl;)


 mLmaXxulsLamsb ;o((ul aw ;l;a; Xk 6sb bXxl;saXsb ((Xa(Xls ( X;am
xo;saox mssbsamsb tmanu U x msa X  l(s  aX ; mlmUlssab X( osl;aXls;
 ;lUm  )
yofoJ CNFBaRBNC
b X l;maXmaxlFslamlmsbl;omulm 6a( mcu u;  sL;soL)
yofoV BGS CGBCT
  aX l;( m;lmU6sb ;ls (bXxl;saXbl;fb XX (X ; msslk xo;sb tsbsoulsowlxl;lm
aXm nlsbsb (Xaos;( l lslam;msb kullsLl;nlsblmsb X cs ;sm w(lXLs )

b  wsa; msb s mslx a xlml;sXslama oulsowlxxo;s X aX nlsblmsb 
6;oi sh;x luX aX;6mfaXlmsb XoUaomslulsLX aX;)sbmox X;a 
oulsowlxxo;s X (aXs nlsblmsb )

b bXxl;saXbl;fb XX (X ; msslk nluuX aXsb s l;( m; m;oi sh;mox Xm
lmlslu;amsb u u;)	 f;b nluuax(u s sb aomslulsL aXx;nlsblm aXxslamam XmlmU
sb l;( m;slama oulsowlx)X (Xslamnluu am Lsb bXxl;saXbl;fb X
X (X ; msslk aXlmUsalm;sXoslam; aX;s Xlu luoslamlmuo nlsblmsb omlsaw ;a 
oulsowlx)luoslam aXoulsowlxl;; auuan;3


BOURBNCGN UOBRU3BF

ulsowlxxo;smas xlw nlsbasb Xx llmu(Xaos;)ulsowlx;baouamuL luos 
lm®)SJu  aX o; )asX kluu  aXasb X;auoslam;;ob;WJ wsXa; mWJ
xmmlsau)



NG N UOBRU3BF
 NKBC UGBNCgNANKR4
NOUF N 
UOBRU3BFg0h
FTvF4
NOUF N Ohobj
RN K FND 
BCODNOUF BC
S K UGBNCT
+W®xU
+Wx
+Wx
%W®x

yofoP FBCBGRKRBNC
•

xlml;sXslamamuL)ulsowlx;baoumas xlml;s X ;m
(o;baXauo;)
•
ulsowlxxo;s b t   aX  lmUxlml;s X  aXuaolm ;;6auaX6;a(L;( s6
aX (a;ls;)
•
ulsowlxxo;smas xlml;s X l a ;masam aXxsasb ;( l lslam;)b 

mk ;slUsaXaXbl;fb XX (X ; msslk xo;slxx ls uLlm aXxb X( osl;)
•

maXm nlsb slamW)9cul;sa (X cx lslamnluu xlml;s X   aX lm o;lam
a oulsowlx)
•
lm lm o;lamcX us bL(as m;lamxLaoX6CRBArS KR CGBD F BRBNCGFr 
.BRAA O%+baoX;(XlaXsamsbXaoUbaoslm o;lama oulsowlx
•
aasb XsX sx msxL acxlml;s X nlsboulsowlxCasb Xsbm aXlxx ls 
lms Xk mslam aXk X;  k msD)
•

sl;X axx m sbsoulsowlx xlml;s X lxx ls uL s Xluoslam)

ulsowlx;baou xlml;s X amuLL;uanlm o;lamkllmsXk mao;Xaos ;;lmUu 
xlml;sXslamak X aoXC+DbaoX;)

b  uanXs l;;( l l lmsb su ; uan)
yofoPo0 ON.R  NK
•
®sa8®Q3%Ja sb sasukauox 
•
8®Qsa9	3 +Ja sb sasukauox 
•
9	sa%	3 9+Ja sb sasukauox 
•
%bsa+	3
I®Ja sb sasukauox 









C UGBNCKR N UOBRU3BF
OBRU3BF
NG 
NRODNOUF 
RN BC UG 

C UGBNCKR 
hRN
ph2
phcRN0	
0	RNf	
f	RNx	
+W®xU
%W®x
9®xf	
%®xf	
8Wxf	
9®®xf	
yofoy T CR	rS KG CGBRBDBRr
OBRU3BF	rS KG CGBRBDBRrC
C UGBNC RBNCGgkluu ssb  ;l (XlaXsa
oulsowlxxlml;sXslamnluu  (lm (bXlm  aX;oosm ao;lmi slam6l(b mbLXxlm 
bLXabuaXl  aX
lmi slam6mX ;o;lsslam Tol(x ms aXsb  x XU mLxmU x msa 


m(bLuslX slam;)ulsowlx;baou xlml;s X lmsXk mao;uLsbXaoUb ls 
ulm )



b 
v


O ViA UO N D CRG


SPte
ayeeg
	sPl
oey1csyePoiego
sPlt
nPtiP
5aSPg e
c:
geaettPyl
1nn1*Td

1goSnl
sPl
i1goS
Pl





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


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

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

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1:oSeP::eaoesPyeP
hyPcgaotdcge
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sicgctoyPoc1g1:
oyePoiego

6eLotA/fts/7gf
,-8/tfLts/7gto7fL7oig
7frtffATiLAse:Afr:7fL




g:1yies1gtego
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nc chcncol
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ei1 yPdScaPgs
escaPncto1yl
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yc1yoyePoiegot
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coPntc gt*ec So
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eTy1n1 caPn5Pi
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Ph1yPo1ylPttettiego
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cies
11o Pnr

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smeytemegot

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0h

bl;l;(XlxXL;  sL;soL6osn X lms X ;s lmX aXlmU(as mslux ;oX ;a    lL)
b ; nluu ;; ;; ;; amXLulmlu m(alms;)XlxXLaosax x ;oX ; aX;  sLX 
 slu lm; slam9% uan)

  BrCSNBCRG
ulmluaosax ;nluu xamlsaX  aX   lLo;lmUsbX   omslamum oXauaUls ;s;6sb 
w(m l;lulsLsso;u CD6lx %Wcaasutm	lUbamsX;sl;ouolsL
C	D)b ; nluu ;; ;; L;9mWa ba;(lsulFslammn  tuLsb X  s X aXsb  lX;s
sbX  n  t;CL;98m%®oXlmU( Xla;m   D)
mlslam6n nluuo; Tomsl lu 

(Xx s X;;; amXL m(alms; ;Xl  uan)



b oXsFt w(m l;lulsLsso;u CDn; k ua( sax ;oX sb l;lulsL
;sso;a ;oi s;nlsbxousl(u ;u Xa;l;)
suuan;mai slk Tomsl lslama sb u k ua 
 omslamlmUsbsaou nl uLmX (XaoluLo; LX ; Xb X;mb usbX (Xakl X;)
b (Xakl ;sasu;aX am;u sbsXmU ; Xax®sa9®)b  lX;su k u;9)®sa+)WX   X
sa( a(u nlsbblUb UX  a xousaXLlulsLmsb ;o; To msu k u;W)®saS)WX   Xsasb 
ua;;a xousaXLlulsL)b XmU a xlms UaXl ;lmuo C®D/maXxum oXauaUl wx0sa
CWD/xousaXLnlsbaoslaXX ;s aX%®®x s X;0l;lulsL; k X  maoUbsalx(lX ouuluL
slklsl ;0saC9®D/ sbo sa)
mlslam6lsu;a(Xakl ; lUbs;o;u x ;oX x ms;
uu omslamuL;s xCD;aX ;)b ; ;o;u s UaXl ;X ul;s lm(( mlw%)



	lUbamsX;sl;ouolsL3	lUbcamsX;suamu ss XbXs;X X luLkluu m(Xakl 
(Xslu6Tomslsslk 6m;smXlF ;; ;;x msa kl;ou omslam)bbXsam;l;s;a Xan;
a utu ss X;C X ;lmUlm;lF  Xaxsa(saassaxDamnbls tUXaom)

aXsbl;sXlu69®®JxamaouXblUbamsX;skl;ouolsLnluu x ;oX amL;9mWoXlmU
sb ;s Xal(b; mn  tuLoXlmUsb (u;x wbmU (b; )bXs;nluu X s%cx s X
l;sm LsXlm  wxlm X;lmsb ba;(lsuXaaxnlsbam;smsulUbslmUa I®c9®® aascmu ;
ax(ul;b o;lmU;smX uoaX ; msba;(lsuXaaxak Xb ulUbslmU)lmaouXs ;slmUnluu 
X aX ;sasumox Xa u ss X;l msl l aXX suLCxwlxoxE®D)

eBsCttI 

lx %Wc aasnutlmUsXlu;nluu ;; ;; amL;9mWoXlmUsb ;s Xal(b; mn  tuL
lmsb (u;x wbmU (b; )b lx %Wcaasuts ;sl;Tomslsslk x ;oX a uan X
 wsX xlsL omslam)
 X TolX 6sb ;oi sxLo; m((Xa(Xls ;;l;slk  kl sanut;
ToltuL;b f;b m Xaxam  msasb asb X ma u XuLxXt 6oma;sXos 6%Wc aas
aoX; )k XL   aXsnluu x sao; sb ;x s ;slmUbuunL aX k XLlx %Wcaasut
s ;s)as mslu aX ws Xmul;sXslam;;baou t (ssaxlmlxox;xob;(a;;lu );oi s
nluu;smnlsbsb sa ;a bl;fb X;ba ;amsb ;sXslmUulm Cl msl l Ls( xXtamsb 
 uaaXDmslxlmUnluu Ulmnb mmL(Xsa sb ;oi sQ; aasXa;; ;sb s( )lxlmUnluu m
nb mmL(Xsa sb ;oi sQ; aasXa;; ;sb  lml;bulm Cl msl l Ls( xXtamsb  uaaXD)
lx nluu X aX lm; am;mXaom sasb m X ;ss msba ; amo;lmU;sa(nsb
(Xakl  aXsbl;sXlu)b s;tl;lxx ls uLxlml;s X UlmLbklmUsb ;oi snutt
sb ;x l;sm )b k XU a sb snakuo ;nluu X aX lmsb ; X (aXs aXx)

L RBD   BrCSNBCRG



;nluu ( X aXx  aX;smXa X mX ; Xb(oX(a; ;mnluu o; saxt 
ulmlu l;lam;aos ;uslama lxxoma;o((X ;;lk sX sx ms)aXsbl;sXlu6sb 
;nluu
u;a muLF  aXsna(Xx s X;3u mUsbm%bL( Xlms m;lsLlmsb ;(lmuaXma(sl
m Xk mu mUsba 9(a;scamsX;s mbm x msl kluu )

ox Xa L;lmsb ba;(lsumX TolX x ms aX(u;x wbmU nluuu;a X aX amsb 
;)
0ho0




CR CRlRNlK Rouu;oi s;nbaX  lk am a; a sXluXoUnluu lmuo lmsb lms mscsac
sX sUXao()

 KlKNRNNOouu;oi s;nba( X aXx uukl;ls;lmaXm nlsb(Xasaaunlsbaos;lUml lms
(Xasaau klslam;aXklauslam;)

OOUL RK RF CRKNUSouu;oi s;nbaX  lk am a; a sXluXoUCD)




00




bl;; slam ;Xl ;sb ;ssl;slux sba;sa o; samuLF sb    lLm;  sL
 m(alms;) aXxu;ssl;slumuL;l;(umCD6nblbxo;s  lmulF   aX s; uat6
nluu(Xakl lslamu slu; aXsbmulmU(Xa oX ;6;ssl;slux sba;6ms
(X ; msslam;C )U)6su 6ul;slmU6m lUoX ;b uu;D)b  lmuulmlu;soLX (aXsnluu ;Xl 
 klslam; Xaxsb 6l mL)
00o0

	rSNRA GBG
bl;sXlul; w(uaXlmUsb ;  sLa oulsowlxlmsb sX sx msa fX u(; ;)b 
bL(asb ;l;l;sbssb oulsowlxX Ulx m(Xa(a; lmsbl;sXlul;;  msau Xu lmsb 
f(sl ms(a(ouslam)b ai slk ;a sb sXlunluu ;; ;; sbXaoUbsb o; a 
;oxxXL;ssl;sl;)

FSO Ba NCGB KRBNCG
b ;x(u ;lF a W;oi s;l;; am  ;llulsLmuaUl;sluam;l Xslam;amsb mox Xa 
;oi s;sbsnluuX k u;lUml lmsXl;taXsau XlulsLl;;o a o;lmUoulsowlxH;s Xal;)
sl;
msll(s sbs9;oi snluu lu;X  mlmUm9nluuXa(aosak Xsb aoX; a sb sXlu6 aX
sasua +;oi s;nbaX  w( s saax(u s sb sXlu)oi s;nbanlsbXnnluumas 
X (u )
00of



CR KBFCOrGBG

b X nluu malms XlxmuL;l;)

RRBGRBOCOrGBG

;oxxXLa sb mox Xm( X msU a ;oi s;nlsbmLk X;  k ms6mL; Xlao;k X; 
 k ms6k X;  k ms;u lmUsa( Xxm msl;amslmoslama sXluXoU6msXluXoUcX us 
k X;  k ms;nluu X (aXs )

bmU lmm oXauaUlaosax ;amsb 6lx %Wcaasutm	;u ; Xaxxl;;lam
sal;bXU nluu muLF L(lX scs ;s;nlsb;lUml lms(ckuo ;am;l X u ;;sbm®)®W)

L
6u mUsba %bL( Xlms m;lsLmu mUsba 9c(a;samsX;s mbm x ms;baou ;su 
aXX o Ll;bXU )(lX scs ;snluu o; saax(X bmU ;lmsb ; kuo ;nlsb
;lUml lm am;l X s(ckuo ;u ;;sbm®)®W)

amslmoao;snluu  ;Xl o;lmUsb  auuanlmU ;Xl(slk ;ssl;sl;3m6x m6x lm6
xlmlxoxmxwlxox)snluu l;(uL lmuuul;slmU;;aXs L;oi smox X)

b maomssX (X ; ms 6sb ( X msU nluu ;o((X ;; nb msb aomsl;F XalmaX X
saXnss mslamsasb mamcF Xaaoms;)Xan mas pl;;lmUenluu lmuo lmaoms
souslam;nb X m  ;;XLsaaoms aXXa(aos;mxl;;lmUkuo ;)mu ;;asb Xnl; 
;( l l 6sb  maxlmsaX aX( X msU ;nluu sb mox Xa ;oi s;nlsbmamcxl;;lmU
;; ;;x msnlsblmsb muL;l;(a(ouslama lms X ;s)

 X;lamS)%nluu o; sa( X aXxuumuL; ;)


00op


b 
ms mscsacX sC
D(a(ouslamnluuo;  aXsb a  llumuL;l;)

b   sLa(ouslamnluulmuo uu;oi s;nbaX  lk am a; a sXluXoUCD)uu;  sL
;; ;;x ms;lmuolmUsawllsLnluu ( X aXx amsb   sLa(ouslam)

b  XcXasaaua(ouslamCDnluuam;l;sa uu
;oi s;nlsbaosxiaX(Xasaau klslam
aX(Xasaauklauslam)b Xls Xl aXxiaX(Xasaau klslamaXklauslamnluu  s Xxlm m
aox ms (XlaXsas; uat)oi s wuo;lam Xaxsb (a(ouslamnluuu;a 
 s Xxlm maox ms (XlaXsas; uat)o((aXslk muL; ;xL ( X aXx ; 
amsb (a(ouslam)
00ox



b l;(a;lslama ;oi s;lmuo ;sb mox Xm( X msU a ;oi s; aXsb  auuanlmU
s UaXl ;3;oi s;sX s C;  sL(a(ouslamD6;oi s;lmsb 
(a(ouslam6;oi s;ax(u s 6
m;oi s;l;amslmo  Xaxsb sXlu)uu( X msU ;nluu ; amsb mox Xa ;oi s;
 mXauu )b X ;am; aXsXlul;amslmoslamnluuu;a ;oxxXlF lmsbl;su )muLam 
X ;am aXsXlul;amslmoslamnluu X aX )	an k X6uuX ;am;nluu (X ; ms lmsb 
ul;slmU)

ul;slmUnluu(X ; mssam XmlmU;oi sl;(a;lslam)
00oJ	

	


; ulm  xaUX(blmulmlubXs Xl;sl;nluu ;oxxXlF ;( X msU ; aXs UaXlu
kXlu ;m;x m6;smX klslam6x lm6xlmlxoxmxwlxox aXamslmoao;
x ;oX ;)b muL; ;a ; ulm bXs Xl;sl;nluu ( X aXx  aXsb 
a(ouslam)
00oV




XlaXmamaxlsmsx lslam;nluu ;oxxXlF  aXsb   sL(a(ouslamLaXu	 usb
XUmlFslamC	Dm lslamXL)oi s;xLbk xaX sbmam x lslam( X
XoUu;;m(X   XX s Xx)s bu k ua ;oxxXlFslam6;oi sl;aoms am l b f;b 
X (aXs am aXxaX x lslam;ssbsu k u)

XlaXx lslam;X   lm ;x lslam;nlsb;sa(s aoXXlmU  aX sb s a X  lklmU
 lX;ssXlusX sx ms)amaxlsmsx lslam;X   lm ;x lslam;nlsb;sXss ;
aoXXlmUamaX s Xs a X  lklmU lX;ssXlusX sx ms) lslam;nlsb;sXsm;sa(s ;
nblbXt ssb s a  lX;sa; nluu ;oxxXlF ;asb(XlaXmamaxlsmsx lslam;)
00oP
	

 lubl;saXLnluu (soX ssb X  mlmUkl;ls) lubl;saXLnluu a o;lmU 
mnluu ;oxxXlF L ;L;s xaXUmu;;m(X   XX s Xx aXsb   sL
(a(ouslam)
00oy
b a; CxUDa sXluXoUxlml;s X CD6msb oXslama sX sx msnluu ;oxxXlF 
nlsb ;Xl(slk ;ssl;sl;)b (Xa(aXslama ;oi s;ax(u slmUsb lm o;lama sXluXoUCD
nluu ;oxxXlF )


00ob

 amXL m(alms;a ulmluaosax ;nluu xamlsaX  aX   lLo;lmUsbX   omslamu
m oXauaUls ;s;6sb w(m l;lulsLsso;u CD6lx %Wcaasutm	lUb
amsX;sl;ouolsLC	D)b ; nluu ;; ;; L;9mWa ba;(lsulFslammn  tuL
sb X  s X aXsb  lX;ssbX  n  t;CL;98m%®6l m   D)b (XlxXLmuL;l;nluu 
bmU  Xax; ulm saLS®msb ; amXLmuL; ;nluu bmU  Xax; ulm saL;
W6%®6mExamsb;)

aXsbl;; amXL   lL m(alms6sb 
;nluu muLF  aXsna(Xx s X;3u mUsba %
bL( Xlms m;lsLlmsb ;(lmuaXma(slm Xk mu mUsba 9(a;scamsX;s mbm x msl 
kluu )b ; amXLmuL; ; aX
nluu bmU  Xax; ulm sal;bXU amLWaX
%®6;n uu;bmU  Xax; ulm sa auuano(sLS®)

ox Xa L;lmsb ba;(lsumX TolX x ms aX(u;x wbmU nluu ;; ;; o;lmU
 ;Xl(slk ;ssl;sl;)








0f


0fo0
  sL kuoslam;nluu ; amsb lml m 6lms m;lsL6msL( a k X;  k ms;6;n uu;
amulmluuL;lUml lmsbmU ;lmsb ;oi sh;(bL;lu wxlmslam6klsu;lUm;6mulmlu
uaXsaXLX ;ous;)  sLmuL; ;nluu ( X aXx o;lmUsb ;  sL(a(ouslam)  sLkXlu ;
nluu sous m(X ; ms )w(a;oX sasXlusX sx msmX ;am; aXl;amslmoslama 
sXlusX sx msnluuu;a sous )
0fof
k X;  k msCDxamlsaXlmUmX (aXslmUl;Xaoslm (Xsa  k XLulmlusXlu)b  auuanlmU
ul;sa ;msb bXs Xl;sl;a ma; Xk C slamI)%Dnluu s Xxlm nb sb Xsb  k ms
X TolX ; w( ls X (aXslmUlmlslamsaXaoslm X (aXslmU)
0fop	


R KFg GKBSRBNC4CTK ib  ;Xl(slam;mUXlmU;u ; aomlmsb 
X kl; 
axxam XxlmauaULXls Xl aXk X; k ms;CDk X;lam+)®nluu oslulF 
 aXX (aXslmU)uu((Xa(Xls sX sx msX ;;baoubk  ;;saa(La sb 
k X;lam+)®)a(La sb k X;lam+)®m anmua  Xaxsb n ;ls 
bss(3ffs ()m X)Uakf(Xasaau k ua(x msf u sXamlA((ulslam;fs)bsx)

e3S R C GG2i;m ym w( s haXyw( s h aX w( ls X (aXslmU(oX(a; ;amuL)

0foxl






b X X ma wuo;lam; aX w( ls k X;  k msX (aXslmU)uuk X;  k ms;6lmuolmU sb6
nluu am;l X om w( s m;oi ssa w( ls X (aXslmU)
0foJ
uu;m;aoXXlmUamsXlunluu ul;s L;oi s)b  X To mLm( X msU ;a 
;oi s;nlsbsX sx msc x XU msk X;  k ms;C;Dnluu sous L;L;s xaXUmu;;
CDm6nb X sX sx msc x XU msl;  lm ;mLsbs3

•
oX; s X lX;sa;lmUa sXlux lslammsbXaoUbsb  ma sb sXluaXo(sbXaoUb
8®L; s Xsb u;sa; a sXlusX sx ms6aX
•

;am;l X sX sx mscX us X UXu ;;a sb ;sXss a sb  k ms6aX
•

;(X ; ms  aX  lX;sa;lmUa sXlux lslamosnaX; m;lmlms m;lsLaXsb lmk ;slUsaX
;o; To msuLam;l X;sX sx mscX us )

;sbsX am;l X su ;s(a;;luLX us sasXlusX sx msnluu sous ;n uu;
 sb;6;6m k ms;X ;ouslmUlmsX sx msl;amslmoslam)

;sbsaoX s Xlm aXx am; msos  aX  lX;sa;lmUa sXlux lslamnluumas 
;oxxXlF osnluu ul;s )

s bu k ua ;oxxXlFslam6;oi snluu aoms amuLam  aX b66aX
 w( Xl m nlsblmsbsu k u)
msb ;oxxslam aX; k XlsL6nlsblm bu k ua 66aX
 w( Xl m 6sb am nlsbsb blUb ;s; k XlsLnluu lmuo )
msb ;oxxslam aXh;


X uslam;bl(sasb sXluXoU6nlsblm bu k ua 66aX w( Xl m 6sb am nlsbsb 
ua; ;sX uslam;bl(sasb sXluXoUnluu lmuo )
0foV



mk X;  k msCDl;mLomsanXx luaoXX m lm;oi saXulmlulmk ;slUslam
;oi sxlml;s X (bXx oslu(Xaos)ma ;masm  ;;XluLbk sabk o;u
X uslam;bl(nlsbsbl;sX sx ms)mk X;  k msCDmsb X  aX  mLom kaXu m
omlms m ;lUmClmuolmUmmaXxuuaXsaXL lmlmU6 aX wx(u D6;Lx(sax6aXl; ; 
s x(aXXluL;;als nlsbsb o; a x llmu(Xaos6nb sb XaXmasam;l X X us sa
sb x llmu(Xaos)bl;lmuo ;mLaoXX m sbsl;m nlmam; saXUUXks lm; k XlsL
aX X To mL Xaxsb ; ulm amlslam)


mulmlu;sol ;6mmlmuo mom ;lXu x luamlslamaoXXlmUsmLslx 6
lmuolmUXomclmaXn;baos( Xla;6 k ml masXlusX sx msb;  mxlml;s X )b 

axxam XxlmauaULXls Xl aXk X; k ms;CDk+)®l;sa o;  aXsb UXlmUa 
; k XlsLa ;Lx(sax;mmaXxu lmlmU;)aXk X;  k ms;masak X Lsb 
c
 X;lam+)®UXlmU;L;s x6sb  auuanlmU  lmlslam;nluu o; 3

•
K 03lu0;Lx(saxslaXxlu;Lx(sax;0ulmluaXlUma;sla; Xkslam;amuL0
lms Xk mslammaslmls )
•
K fia Xs 0xlmlxu6uauaXmamclmk;lk lms Xk mslamlmls 0ulxlslmUU c
((Xa(Xls lm;sXox msu,)
•
K p3 k X aXx luuL;lUml lmsosmaslxx ls uLul  csbX s mlmU0
ba;(lsulFslamaX(XauamUslama ba;(lsulFslamlmls 0l;ulmU0ulxlslmU; u cX 
,,
•
K x3l  csbX s mlmUam; To m ;0oXU mslms Xk mslamlmls )
•
K J3 sbX us sa)

b 
mk ;slUsaXxo;su;a;; ;;sb X uslam;bl(a mLk X;  k mssasb o; a sXluXoU6
; amkluu lm aXxslam6o;lmUsb  auuanlmUUol ulm ;3

•
NR OR 3u Xcoss x(aXumfaXx bml;slX uslamsao; asb Xsbmsb sXlu
XoU)
•
NUR UO3b X l;maX ;amu (a;;llulsLsbssb  k msl;X us sasb sXluXoUos
  lmls o; mmas ; Xslm )
•
NGGBO 3b X l;;sluuX ;amu (a;;llulsLsbssb o; a sb  k msn;sb sXluXoU
ossb X  wl;s;xaX ult uLo; a sb  k ms;ob;ax(ulslam;a (XaUX ;;lk 
l; ; )
•
KNO 3b xa;sult uLo; a sb  k msl;sb sXluXoUosasb Xo; ;mmas 
ax(u s uL wuo )
•
  BCBR iu Xoss x(aXumfaXx bml;slX uslamsasb sXluXoU)uuasb Xo; ;
bk   m ulxlms )k ms;u;;l l ;  lmls nluua s m am lXx Laox mslmU
X ;auoslamaml;amslmoslama sb sXluXoUmX oXX m o(amX ;ox(slam)
0foVo0  NKBCTN D KG D CRG
uuk X;  k ms;a mL;oi soXlmUsb aoX; a sb sXlunluu X (aXs amsb ; X (aXs
 aXx6msb lmk ;slUsaXnluuUlk bl;aXb Xa(lmlam;sasb X uslam;bl(a sb k X;  k mssa
sXluXoUsX sx msCl) )6nb sb Xsb  k msl;X us aXomX us sasXluXoUxlml;sXslamD)
 
sb k X;  k msl;; Xlao;6ls;baou X (aXs ;;aam;(a;;lu mmaUX s Xsbm%+baoX;


sab X( osl;msb blXa )b abm;	a(tlm;
xo;su;a masl l ;
X TolX Labm;	a(tlm;
Uol ulm ;)sb XomsanX k ms;aoXXlmUlmsb  Xx naXta 
ulmlusXluX u;asa X aX ;;Cl) )6;sbsaoX(XlaXsa;;lUmx msa sXlu
sX sx mssbsX X us sa(Xasaaucxms lms Xk mslam6lmuolmUlmk;lk (Xa oX ;;ob
;la(;l ;6x lslamn;baos6aXmasX sx msXomclmD)

uu;X UXu ;;a ; Xlao;m ;;aXX uslam;bl(saoulsowlxsX sx ms;(mmlmU Xaxsb 
;lUmsoX a sb lm aXx am; ms aXx6omslu8®u mXL; s Xl;amslmoslamaXax(u slam
a (Xasaauc;( l lsX sx ms;  lm Lsb (Xasaau aXsbs;oi s6X sa X aX amsb 
)
0foVof CNKFONKRNKrOU GCBROBTCG
b X (aXslmUa maXxulsl ;a klsu;lUm;;k X;  k ms;;baou kal )maXxulsl ;a 
klsu;lUm;;baoumas X (aXs omu ;;mLXls Xlam aXml; ou luu 6sb klsu;lUm;
maXxulsl ;o; sb ;oi ssal;amslmo sXlusX sx ms6aXsb lmk ;slUsaXlm;l;s;sbssb 
maXxulsL;baou X (aXs ;m)mLUX 8aX+uaXsaXLmaXxulsLaXmLulmluuL
;lUml lmsUX 9aX%b xsauaULaXlab xl;sXLuaXsaXLkuo C;D;baou X aX ;m
)
 mmaXxuuaXsaXLkuo aXklsu;lUml;;;als nlsbulmlu;lUm;mfaX;Lx(sax;6
sb ;lUmaX;Lx(sax;baou X (aXs ;m6msb ;;als uaXsaXLkuo aXklsu;lUm
;baou am;l X lslamulm aXxslamsbsxo;s auu s amsb X u kms)

ulmluaXsaXL ;ous;nluu ;oxxXlF )oxxXL;ssl;sl; aXsoukuo ;m aX
bmU ; Xax; ulm nluu sous  aXuaXsaXLX ;ous;L;b ou kl;ls)oi s;nlsb
uaXsaXLkuo ;aos;l a sb maXxuX   X m XmU smL(a;sc; ulm ;; ;;x msnluu 
;oxxXlF 6mUX ( X
 X;lam+)®nb m((ulu )oi slml m a 
uaXsaXLsawllsLnluu ;oxxXlF m;;lUm xwlxoxUX  aX buaXsaXLs ;s)
0foVop 	COBCTN D KG D CRG
uuk X;  k ms;X ;ouslmUlml;amslmoslam Xaxsb sXlu;baou  auuan omsluX ;auoslamaX
;slulFslam)oi s;xo;s  auuan  aX; aX8®u mXL; s Xl;amslmoslamaX
ax(u slama (Xasaauc;( l lsX sx ms)uum n;aoXXlmUoXlmUsbl;( Xlaxo;s 
X (aXs m auuan omsluX ;auoslamomu ;;6lmsb a(lmlama sb lmk ;slUsaX6sb ; kuo ;X 
masult uLsalx(Xak  o; a sb om XuLlmUl; ; )
msbl;; 6sb lmk ;slUsaX;xo;sX aX
bl;aXb XX ;amlmU aXsbl; l;lamlmsb ;oi sh;x luX aXm;axx msamsb )
 s X8®L;6amuL;6;6aX sb;;; ;; Lsb lmk ;slUsaX;sX sx msX us X sa 
X (aXs )
0foP

0foPo0   BCBRBNCGN  KBNUGD KG D CRG
b   lmlslam;a ; Xlao;k X;  k ms;C;DX Ulk m uan)b (Xlml(ulmk ;slUsaXl;
X ;(am;lu  aX m;oXlmUsbsuu;s  lmkauk lmsb sXlul; xlulXnlsbsb ams msa sbl;; slam)

maXX slaml;  lm ;mLomsanXx luaoXX m sbs3
•
X ;ous;lm sb6l;lxx ls uLul  csbX s mlmU6
•
X TolX ;su ;s%+cbaoXlm(sl msba;(lsulFslamaX(XauamUslama  wl;slmU
ba;(lsulFslam6
•
X ;ous;lm( X;l;s msaX;lUml lmsl;lulsLflm(lsL6
•
o; ;amU mlsumaxuLflXsb   s)

 lum;l msl lioUx ms;baou  w Xl; lm llmUnb sb X w( ls X (aXslmUl;
((Xa(Xls lmasb X;lsoslam;6;ob;lx(aXsmsx lu k ms;sbsxLmas lxx ls uLul  c
sbX s mlmUaXX ;ouslm sbaXba;(lsulFslam6osxLi a(XlF sb ;oi saXxLX TolX 


lms Xk mslamsa(X k msam a sb asb Xaosax ;ul;s lmsb (X klao;  lmlslam)b ; ;baou
u;ao;ouuL am;l X ; Xlao;)wx(u ;a ;ob k ms;X lms m;lk sX sx mslmm
 x XU mLXaaxaXsbax  aXuu XUlXamba;(;x0uaaL;X;l;aXamkou;lam;sbsamas
X ;ouslmba;(lsulFslam0aX k ua(x msa XoU ( m mLaXXoUo; ) sbo sal; ; 
(XaUX ;;lamnluu X aX amsb )l;  lm ;;o;( s om w( s 6m
X (aXslmUl; max(;; nlsblmX (aXslmUUol ulm ;;  lm lmsbl;; slam)

X sx msnlsblmaXxl;;lamsasb  auuanlmU lulsl ;l;masam;l X sax  ssb Xls Xla 
plm(sl msba;(lsulFslameCusbaoUbl mLasb XXls XlX x s6sb  k msxo;s;sluu 
sX s ;mmlxx ls uLX (aXs D3

•
x XU mL (Xsx msaXx XU mLaax
•
os(sl msaX;x cL;oXU XLomls;
•
; XkslamaX;baXsc;sLomls
•
 blulsslam lulsL
•
	a;(l aX;tluu moX;lmU lulsL
•
oX;lmUbax ;6o;saluX aX ;(ls X  lulsL

	a;(lsulFslamoXlmUsb sXlu aX(X c(umm ;oXUluaXx lu(Xa oX Cam nblbn;
(umm (XlaXsa msXLlmsb sXluDa ;masX TolX X (aXslmU;; Xlao;k X;  k mssasb 
(am;aXCX)lb u kLD)
0foPof  KBNUGD KG D CR SNKRBCTr
CD GRBTRNKG

sl;lx(aXsmssal;slmUol;b sn  mp; Xlao;emp; k X ek X;  k ms;6;sb s Xx;X mas
;LmamLxao;) k XlsLl;x ;oX a lms m;lsL0ban k X6ma ; k X lms m;lsLm  mas
m  ;;XluL am;l X ; Xlao;)aX wx(u 6mo; 6nblb( X;l;s; aX; k XubaoX;6xL 
am;l X ; k X mo; 6osxLmas am;l X m)msb asb Xbm6;sXat nblb
X ;ous;lmamuLulxls  UX  a l;lulsLxL am;l X amuLxlu;sXat 6osnaou 
am;l X m) k XlsLm; Xlao;m ;;;baou lm ( m msuL;; ;; nb mX aXlmU
;m;amsb )

k X;  k ms;u;;l l Lsb sX slmUlmk ;slUsaX;G KBNUGX TolX  w( lslao;bmulmUm
X (aXslmUsasb 
aXasb XX UousaXLU ml ;lmaX Xsaax(uLnlsbX UousaXLX TolX x ms;)
 Xlao;k X;  k ms;xLaoXsmLslx  Xaxsb ;lUmlmUa sb lm aXx am; ms aXx
sbXaoUbsb Scxamsb auuanco(( Xla s Xsb u;ssXlusX sx ms)(am;aXaX ;lUm  xo;s 
masl l a uu;6X UXu ;;a o;ulsL6nlsblm%+baoX;a sb  lX;stmanu U a sb  k msL
sb sX slmU(bL;llmaXX ; Xb( X;amm u)

NK SNKRCtG  RA SSKNSKBR ST o
uu;mx luuLam lXx  sb;CX UXu ;;a o;ulsL;; ;;x msDaoXXlmUamsXlu
sX sx msaXnlsblm8®L;a u;ssXlusX sx msxo;s X (aXs sasb b X( osl;6sb 
abm;	a(tlm;
msb blXa sb ;;nlsblmsb m auuan omsluX ;auoslam
Cnlsbosa(;LX (aXsl ((ulu D)

 sb;aoXXlmUnlsblm8®L; s Xu;ssXlusX sx mssbsX   x y(a;;luLhaXy(XauLh
X us saoulsowlxxo;s X (aXs ;;nlsblmsb Cnlsbmosa(;LX (aXsl 
kluu D)

 sb;aoXXlmUnlsblm8®L; s Xu;ssXlusX sx msmmasssXlos sasXlusX sx ms
C )U)6l; ; (XaUX ;;lamDm  mas X (aXs lmm w( lslao;xmm Xsasb b X( osl;
msb blXa sb 6osm;lx(uL (soX amsb ((Xa(Xls ;mC sbD)
b abm;	a(tlm;
;baou masl l ;;aam;(a;;lu )



b lmk ;slUsaXxo;sX kl nm;lUma  amsb samsb X (aXs)b nluu 
X (aXs sasb (am;aXCaX(am;aX ;lUm  D;aosulm lmsb   sLamlsaXlmUum)


 ml;X (aXs sasb ;(am;aXaX ;lUm  kl w6sb ;x lm aXxslamxo;s  ms X am
sb nlsblm%+baoX;C9o;lm ;;LD)Xm;xl;;lama sb X (aXs;baou am lXx L
sb ;ls ( X;amm u;oxlsslmUsb X (aXs)

auuanco(lm aXxslam aX;mlm aXxslamammamc; Xlao;;sbs ax ; Xlao;;baou
u;a X (aXs sasb ;(am;aXaX ;lUm  ;;aam;lsl;kluu 0sb ; X (aXs;;baou 
;oxlss o;lmUsb ((Xa(Xls )b  slu X (aXslmU(Xa ;;nluu (Xakl sasb 
;ls ;lmsb   sLamlsaXlmUum)


mk ;slUsaX;xo;sX (aXs;m auuanco(lm aXxslamsasb lXX ;(am;lu 
m;slsoslamu kl n
aXC
;Df
m ( m mssbl;axxlss  aXlmUsasb (aull ;a sb X ;(am;lu 

C ; Xbsbl;axxlss  D)
0foy


b (am;aXCX) kLDnlsb;;l;sm  Xaxb X( osl;X X ;(am;lu  aXX (aXslmUX u kms
;sasb ax( s msosbaXlsL6asb X((ulu X UousaXLosbaXlsl ;6m(Xsll(slmU
lmk ;slUsaX;6lmaXm nlsb
	Uol ulm ;6X Uouslam;6mfaXuauX UousaXL
X TolX x ms;)

b (am;aXCX) kLDnlsb;;l;sm  Xaxb X( osl;X X ;(am;lu  aXX (aXslmU
om w( s  suaXul  csbX s mlmU k ms;;;als nlsbsb o; a sb sXluXoUsasb 
X UousaXLU ml ;max( s msosbaXlsl ;kls u (bam aX wnlsblmGu mXL; s X
 lmUmasl l a sb  k ms)b (am;aXnluuX (aXsuuX us osom w( s ;lmuolmU
mamc sbfmamcul  csbX s mlmUX us osom w( s ;;;als nlsbsb o; a sb sXlu
x lslamsab X( osl;msb abm;	a(tlm;
;L;  sLX (aXsnlsblm9+u mX
L;a masl lslam)b X( osl;l;X TolX samasl Lsb )
0fob



mk ;slUsaX;nluuo; aXX sx lus XxlmauaULfam (s;nb mX aXlmU;aX;amsb 
 (aXsaXx;m)auuaTolul;x;mX klslam;nluu kal )

uu;6lmuolmUsba; sbsx  sX (aXslmUXls Xl6nluu X aX amsb 0;sbs
x  ssb   lmlslama mnluulslamuuL X (aXs  auuanlmUsb (Xa oX ;mas lm
 slam9+)G)
0fo0h


	


0fo0ho0
AKFNEBC RBg4FSOBCTi
sl ms;nluubk (bXxatlm slCD;x(ulmUC; XoxD( X aXx ;mas amsb ;b ou 
 uan3
BF SNBCR
X ca; 
9xlm(XlaXsa

8®xlm(a;s
9
EbaoX(a;s
%


%+baoX(a;s
8
G%baoX(a;s
8
9EIbaoX(a;s
8

3ma 
m o;lam
9HfcWxlmos ;
%Hfc8®xlmos ;
8Hfc%baoX;

x(ulmUXa oX ;c

sa(m;sXsslx ;a lm o;lamxo;s X aX msouslx fs ;a ;x(u ;Xnm
xo;s (Xakl )b ;oi snluumasX  lk mLlslamulm o;lam;a oulsowlx)
uu;x(u ;sa aslm  aXmuL;l;a oulsowlxnluu ; Xox)m Ecxuuaa;x(u l;
X TolX  aX b;x(u slx (alms)
 s X msXl oUslam6%ulToas;a ®)Wxua ; Xox;baou ;saX sc%®1saG®1ssb ;ls )m 
ulToasnluu ; mssab X( osl;msb ; amulToasnluu ;bl(( sab X( osl;
 s Xsb  lX;s;x(u l;X  lk Lsb x)uu;x(u ;xo;s ; msnlsblm9+L;a  lmU
auu s  Xaxsb ;oi s)
((Xawlxs uL; k mCGD;x(u ;ak XGL;;baou auu s  aXsb muL;l;a 
oulsowlx)

0fo0hof
FSO NOO RBNCCKN GGBCTi
)  Xl(b Xuuaal;sa Xnmlmsab (XlmlF koslm Xso ;)b (sl msh;lmlslu;6
slx ;x(u aslm 6ms ;x(u n;aslm ;baou X aX am bso 
;n uu;amsb X ;( slk slx ;b  slmsb )
) lsblm%®xlmos ;a auu slam6 msXl oU sb uaa;x(u ;sS®®wU aX9Wxlmos ;sa
; (Xs (u;x)
) aX b;x(u auu s 6(l( ss o(uls ulToas;a (u;x6%xu b6lm
(auL(Xa(Lu m XLaklu;ComD)ulToas9l;sb ;x(u mulToas%l;sb o(uls )
) ulToas;X sa  XaF mm;saX sc%®1saAcG®1aXuan Xomslu;( lx m;X 
;bl(( sa;bl(( sab X( osl;)uu;x(u ;xo;s ;bl(( nlsblm9+L;
 auuanlmUauu slam aX oXsb X;saXU mfaXmuL;l;)
 ) ( lx m;m sb  aX;bl(x msam uu;x(u ;bk   mauu s  aX
(sl msnlsblm9+L;a  lmUauu s )
0fo0hop
FSO ABSSBCT
) x(u ;xL ;saX ssb ;ls  aXo(sa9+L;)x(u ;X sa ;bl(( ak XmlUbs
lm;o  ll msXLl sat  (;x(u ; XaF m)
) m ulToas Xax b;x(u nluu ;bl(( msb o(uls ;x(u ;m ; ms
am b X( osl;k Xl l ;sb Lbk X  lk sb  lX;sulToas)Ulm6uu;x(u ;
xo;s ;bl(( nlsb9+L;)
) amas;bl(;x(u ;mo(uls ;lmsb ;x aw)k sb o(uls ;m;bl(sb x
 s Xb X( osl;b;k Xl l sb Lbk X  lk sb  lX;sulToas)
) u sb (sl ms uan;b  s;lm; (Xs (u;slUmsb m(u lmsb ;bl((lmUaw)
 ) u ; amssb X( osl; lsb XL(bam aXL xlu  aX ;bl((lmU;x(u ;)
bl;l;sa;;oX sbs;bl(x ms;m X  lk amsbsL)bl;l; ;( luuL
lx(aXsmsl ;bl((lmUamboX;L aXXlL ulk XL)




0fo00oJ
K l3BGRBCT BONCBRBNCG
(X c wl;slmUx luamlslaml;am sbsl;(X ; msssb ;sXsa sb sXlu)obamlslam;nluu
 X aX amsb sXluh;((Xa(Xls x lubl;saXL)(X c wl;slmUx luamlslamnluu 
X aX ;maXamuLl sb  X To mL6; k XlsL6aXbXs Xa sb amlslamnaX; m;
oXlmUsb sXlu)b mX aXlmU;ob k ms;amsb ((Xa(Xls ;  (aXsaXx6lsl;lx(aXsms
saamk Lsb am (ssbssb (X c wl;slmUamlslamb;bmU LlmuolmU((ulu 
 ;Xl(saX;)
0fo00oV
K TCCrtNKRBNCtBKRA   RGvNCT CBROCNFOB G
X UmmL6aXslam6lXsb   s;6mamU mlsumaxul ;X  k ms;a ;( lulms X ;s6;
 ;Xl  uanlm; slam9%)99)G)
0fo00oP
KNRNNOl  BC D CRGN S BO
CR K GR
b  auuanlmUX  k ms;a ;( lulms X ;s6mnluu X (aXs  w( lslao;uL3

K TCCrtNKRBNCtBKRA   RGvNCT CBROCNFOB G

 ;oi s ax ;(X Ummsnblu  mXauu lmsb sXlu6b X( osl;nluu masl l 
 w( lslao;uL6X UXu ;;a nb sb XaXmaslsx  s;sb Xls Xl aX w( ls X (aXslmU)aXslam;
C;(amsm ao;6l msu6aXsb X( oslDnluuu;a X (aXs sab X( osl;)

amU mlsumaxul ;flXsb   s;O.rGx  sXls Xl6mnluusb X  aX   w( lslao;uL
X (aXs ;m6o;lmUsb (X klao;uL ;Xl (Xa ;; aXX (aXslmU)

KBOKUTD KNG 
Lx(saxslmmamc;Lx(saxslak Xa; nluu X (aXs lmsb )mLl msuaX
lms mslamuak Xa; nlsbsb sXlusX sx mssbsl;;Lx(saxsl6 k ml mas ou luulmU; Xlao;m ;;
Xls Xlam6nluu X (aXs sab X( osl;lxx ls uLCnlsblm%+baoX;Do;lmUsb 
aXX ;(amlmU(U 6m auuanlmUsb ;x (Xa ;; ;Xl  aX;C;   slam9+D)
 
sXluXoUak Xa; aoX;6;oi s;nluu;sa(sXluXoUa;lmUm ulmluuLxamlsaX ;
((Xa(Xls 6xmUlmU;Lx(sax;f;l     s;sbsxLaoX)




0p


mlm ( m msnluu lmbXU a X kl nlmU;  sLs)
maX Xsa m;oX ;  sLmulxls
sawllsL aX mXauu ;oi s;6sb nluux  ssu ;sam C(XlaXsa;oi s mXauux ms
CaXUmlFslamux  slmUDD6 s Xsna;oi s;bk   mlm o; nlsbsXluXoUm lmu;  sL
X kl nx  slmU s Xsb  l sb;oi sax(u s sb ;soL)b  auuanlmUk X;  k ms;nluu 
 auuan Lsb 3m osXa( ml6sbXaxaLsa( ml6lm  slam6m u kslam;lmulk X mFLx ;)
b ;  k ms;nluu X kl n Lsb nb msnaC%D;oi s; mXauu bk ax(u s 
sX sx msnlsbm;s Xal;aX k XL;lwCxamsb;D6nblb k XaoX; lX;s6oXlmUsb aoX; a 
sb sXlu)uuasb X; Xlao;mmamc; Xlao;k X;  k ms;nluu aox ms )b nluuuaat
ssb sasu;  sLslm s XxlmlmUnb sb Xlsl;(a;;lu saa; sb m wssbX  C8D;oi s;lm
sbl;sXlu)





0x





0xo0



b (Xa(a; ulmlusXlul; lmU;oxlss sasb ;
mk ;slUsaXc
mlsls Xlusa 
( X aXx sam ulmlu;ls Cabm	a(tlm;Dm;m
mk ;slUsaXc
mlsls 
xlmslm LX)
lb u kLa abm	a(tlm;mlk X;lsLbaaua  llm )

b (am;aXCX) kLDnluu sXm;  XXlmUsb X UousaXLaulUslam aXxamlsaXlmUsbl;sXlum
sxmU x mssab X( osl;6
m)ls xamlsaXlmU;buu amos sa m;oX sb boxm
;oi s(Xas slam6sXlu(Xa oX ;6uaXsaXL6sXlulms Xk mslamxlml;sXslam6ms
auu slam(Xa ;; ;X a blUbToulsLmx  ssb b X( osl;;6f
	m6nb m
((Xa(Xls 6X UousaXLUol ulm ;)b ls amlsaXlmUum;buu  lm ;( s;a sb xamlsaXlmU
(Xa ;;)

b X( osl;nluukl;lsabm;	a(tlm;nlsblmExamsb;(XlaXsalmlslslmUsb (Xasaausalm;( s
sb XoU;saXU X 6m ouuLlm aXxsb 
mk ;slUsaXa bl;fb XX ;(am;llulsl ; aX;sol ;m
sb (Xa oX ; aX;;oXlmU Tos maXX saox msslam)sXlulmlslslam;ls kl;lsaX
s u am  X m nluu ( X aXx saX kl nlmk ;slUsaXX ;(am;llulsl ;6sb (Xasaau6mls;
X TolX x ms;nlsbsb 
mk ;slUsaXC;D)oXlmUsb lmlslslam6sb ; X (aXs aXx;C;Dm
asb X( Xslm mssXluxs Xlu;nluu X kl n nlsbsb lmk ;slUsaXh;X ; Xb;s  )oXlmUsb 
aoX; a sb sXlu6b X( osl;nluuxt kl;ls;sasb ;ls ;;m  ;;XLlmaX XsaX kl n
(Xasaauax(ulm 6 wxlm ;6mlmlklou;oi sx luX aX;6m m;oX sbssb 
sXlul; lmUamos aXlmUsasb (Xasaaum( Xslm msX UousaXLX TolX x ms;) u s 
 msXl ;nluu k Xl l nlsb;aoX aox msslam)b X kl na x luX aX;nluu am 
lmxmm Xsa;;oX sbs;oi sam l mslulsLl;xlmslm )






0J	
t

t


bl;sXlunluu amos aXlmUsasb ;smX;a aaulmluXsl aosulm lmsb 
	
EXl(Xsls ol ulm mlsu %9(Xs89%6((ulu Uak Xmx msX Uouslam;6lm;slsoslamu
X ; Xb(aull ;m(Xa oX ;mmLasb Xuau((ulu X UousaXLX TolX x msC;D)
0Jo0

b sXlu(Xasaau6
6
6kluu ;  sLlm aXxslam6;oi saox ms;6;oi sX Xolsx ms
(Xa oX ;C )U)6k Xsl; x ms;D6lm aXxslamaos(Lx ms;Cl) )6
(Lx ms;Dm
ax( m;slamkluu sasb ;oi s;maox msslam kl mlmUsb 
h;Toul lslam;xo;s
 ;oxlss sasb 
 aX sbluX kl nm((Xaku(XlaXsasb sXlu;sXs)

b (am;aXCX) kLDmfaX ;lUm  nluu auuanuum  ;;XLX Uouslam;sa m;oX lmlslum
amUalmU6
sXluX kl n)b (am;aXCX) kLD6;((Xa(Xls xo;s;oxlsm6nb X 
m  ;;XL6aslm((Xaku Xaxsb 
 aXuu;o; To ms(Xasaaux mx ms;mbmU ;sa
sb lm aXx am; msaox ms)


 ((ulu 6sb 
nluumasl Lsb 
.BRABCbhrGa sb  ma sb sXlu6aXl sb sXlu
s Xxlms ; XuL6sb 
xo;smasl Lsb 
.BRABC0xrGa sb s Xxlmslam)X ;am aXsb 
 XuLs Xxlmslamxo;s (Xakl C;  lm lmlX slk %®®9f%®fD)b (am;aXnluu lsb X
(X (X aXX kl nuu;oxl;;lamaox ms;(XlaXsa;oxl;;lamsasb 
)

  sLo(s ; aXoulsowlxnluu (X (X Lsb (am;aXaXls;X (X ; msslk C
b X( osl;6
m)D;X TolX 6 aX;oxl;;lamsasb X u kms
)
0Jof
;X TolX LuauX Uouslam;6sb (am;aXCX) kLDnluu m;oX uuu Uu;( s;X ak X 6
m((Xakua sb ((Xa(Xls X UousaXLal ;aslm 6(XlaXsasXlulmlslslam)
 X TolX 6sb 
(am;aXnluuu;a m;oX sbssb lx(u x msslama ;o;smslux mx mssasb (Xasaaum
asb XX u kmssXluaox ms;b(( mamuL s X((XakuLsb X u kmsX UousaXLosbaXlsl ;)

  sLo(s ; aXoulsowlxnluu (X (X Lsb (am;aXaXls;X (X ; msslk C
b X( osl;6
m)D;X TolX 6 aX;oxl;;lamsasb X u kmsX UousaXLosbaXlsL)
0Jop



 slu;a lm;oXm mfaXlm xmlsLnluu amslm nlsblmsb nXlss mUX  x ms sn  m
abm;	a(tlm;mb X( osl;)
0Jox


m aXx am; msl;(Xa ;;Lnblb;oi skauomsXluLam lXx;bl;aXb XnluulmUm ;;sa
(Xsll(s lm(XslouXsXlu6 s XbklmU  mlm aXx a uu;( s;a sb sXlusbsX 
X u kmssasb ;oi sQ; l;lamsa(Xsll(s )
m aXx am; msl;aox ms Lx m;a 
nXlss m6;lUm ms lm aXx am; ms aXx)

b 
nluu ;oxlss  aX((Xakusasb 
sbsl;X ;(am;lu  aXX kl nm((Xakua sb 
sXlu)bam; ms aXxnluulmuo uua sb X u kms u x ms;oXX msuLX TolX Lsb 
X ;(am;lu X UousaXLosbaXlsL6;n uu;uauaomsLosbaXlsLaX;ss X Uouslam;mmslamu
X TolX x ms;)

  aX X Xolsx msm mXauux mslmsasb sXlu6 b(Xa;( slk mls nluu Ulk m ouu
 w(umslama sb sXlu)m sb  ;; mslulm aXxslamb;  m(Xakl sasb (Xa;( slk 
mls 6msb lmk ;slUsaXl;;oX sbssb lmlkloumls om X;sm;sb lx(ulslam;a 


(Xsll(slmUlmsbl;sXlu6sb mls nluu ;t saUlk am; mssa(Xsll(s lmsb sXluL
;lUmlmUmlm aXx am; ms aXx)masslamsbsnXlss mlm aXx am; msb;  maslm nluu
 x lmsb ;oi sh;x luX aX)a(La sb lm aXx am; ms aXx6salmuo sb 
;oi sh;;lUmsoX 6nluu (Xakl Lsb lmk ;slUsaXsasb ;oi s)


 mx mx mssasb (Xasaau;o;smsluuLus X;sb sXlu ;lUmaXsb (as msluXl;t;sasb 
;oi s;6sb ;oi sh;am; mssaamslmo (Xsll(slamlmsb sXluxo;s aslm )
0JoJ



0JoJo0 UL RNC B CRBOBRr
am l mslulsLa ;oi sh;( X;amusnluu (Xas s lmaXm nlsbe:L	 usb
m;oXm 
aXslulsLmaomslulsLsa 9SSEC	
D6mmslamus(Xas slamun;)	

X Uouslam;X TolX sbs6lmaX Xsa(Xsll(s lmsb sXlu6;oi sxo;s;lUmmosbaXlFslam
 Xaxsb sXlusbsb aX;b b;  mlm aXx a  auuanlmU3

•
bs(Xas s b usblm aXxslamC	
Dnluu auu s  Xax;oi s;lmsbl;sXlu0
•
banluubk  ;;sasbslm aXxslammnbL0
•
banluuo; aXl;ua; sbslm aXxslam0
•
bsb usblm aXxslamxL  oXsb Xl;ua; Lsb X l(l ms;a sb lm aXxslam6m
sbsl sb lm aXxslaml;l;ua; sb lm aXxslamxLmauamU X (Xas s L   XuaX
;ss (XlkLun;0
•
b lm aXxslamauu s aossb X ; XbsXlunluu t (s; (Xs  Xaxsb ;oi sh;
x luX aX;6ossb ;oi snluu u saaslmsb X ; XbX aX; s Xsb 
amuo;lama sb sXlu0
•
b sb Xsb osbaXlFslamamslm;m w(lXslams 0m
•
b XlUbs;a X ; Xb;oi ssaX kat bl;aXb XosbaXlFslam)

msb  k mssbs;oi sX kat ;osbaXlFslamsaauu saXo; bl;aXb X	
6sb lmk ;slUsaX6L
X Uouslam6X slm;sb lulsLsao; uulm aXxslamauu s (XlaXsasb X kaslama ;oi s
osbaXlFslam)aX;oi s;sbsbk X kat osbaXlFslamsaauu saXo; 	
6ss x(s;nluu 
x saaslm( Xxl;;lamsaauu ssu ;sklsu;sso;Cl) )6sbssb ;oi sl;ulk Dssb  ma 
sb lX;b ou sXlu( Xla)


max(ulm nlsb
	Uol ulm ;m((ulu (Xs;a %9lsl;X TolX x mssbssb 
lmk ;slUsaXmlm;slsoslam( XxlsosbaXlF X (X ; msslk ;a b X( osl;6sb X UousaXL
osbaXlsl ;msb 
lX s ;;saX kl nsb ;oi sh;aXlUlmux luX aX;ssb ;ls  aX
k Xl lslama sXlucX us (Xa oX ;ms)

 ;oX ;sa(Xas sam l mslulsLlmuo 3amuLomlTo sXlumox Xmlmlslu;nluul msl L
;oi s;amsb aXasb Xaox ms;;oxlss sasb (am;aX)bl;lm aXxslam6saU sb Xnlsb
sb ;oi sh;s a lXsb6nluu o; lmsb s;  aX;oi sl msl lslam)oi smx ;aX
X ;; ;nluumas  ms X lmsb aXs; )axs Xlu XlmU;oi sh;mx nluu 
t (sam lu Lsb (am;aX)oi s;nluu lm aXx a sb lXXlUbs;nlsblmsb 
)
0JoV




 X;amusa sb lmk ;slUsaX;m;oclmk ;slUsaX;xL lmuo lmsb (am;aXs; 6
m;buu sX s lmax(ulm nlsbuu((ulu un;mX Uouslam;)b mXblklmUaX
(Xa ;;lmU( X;amus( XslmlmUsasb lmk ;slUsaXaX;oclmk ;slUsaX6sb (am;aXnluust uu
((Xa(Xls x ;oX ;sa;  UoXm(X k ms ;;sasbl;sLmLomosbaXlF (XsL)


0JoP




b  lmm ; aXsbl;sXlunluu ;oi ssa; (Xs nXlss mUX  x ms sn  msb 
b X( osl;mabm;	a(tlm;mlk X;lsL)uu
mk ;slUsaX lmmlul;ua;oX ;;((ulu sa
%9XsW+nluu ((Xa(Xls uL(Xakl mX kl n Lsb abm;	a(tlm;
)




0V

	

0Vo0	
x mx ms;sasb (Xasaau;buu (umm 6aox ms m;lUmsoX osbaXlF (XlaXsa
lx(u x msslam)


 mx mx mssasb (Xasaaul;X TolX 6sb x mx msnluu aXlUlms maox ms L
sb (am;aX)b nXlss mx mx msxo;s ;oxlss sasb abm;	a(tlm;
 aXsb aXh;
((Xaku)

x mx ms;;( l luuLlmkauklmUbmU sasXlu ;lUm6Xl;tsa;oi s6lmX ; saa;lmUaX
 w(a;oX 6;oi smox XlmX ; 6lslamaXX xakua m ns ;s;aX(Xa oX ;6nluu 
X kl n m((Xak Lsb 
ssb 
mk ;slUsaXh; lulsL)

b x mx msnluu ;oxlss  aXxuuLsasb aXasb XX UousaXLosbaXlsl ;Lsb 
(am;aX;((ulu 6m;( l luuLnb mmlmX ; saa;lmUaX;oi s w(a;oX mfaX
;oi smox Xb;  m(Xa(a; 0aX6nb msb lslamaXX xakua m
mk ;slUsaXl;
m  ;;lss )


s x;X TolXlmU(Xasaaux mx msnlsb
mmfaXmax( s msosbaXlsL
((Xakulmuo 6osX masulxls sa6sb  auuanlmU3

•
bmU sasXlu ;lUm
•
l;tsa;oi s
•

mX ; saa; aX;oi s w(a;oX saXoU
•
oi smox XlmX ; a xaX sbm%®J
•
lslamaXX xakua s ;s;mfaX(Xa oX ;
•
lslamfX xakua m n
mk ;slUsaX


s;baou  oXsb Xmas sbs6l mx mx mssasb (Xasaau;o;smsluuLus X;sb sXlu ;lUm
aXsb (as msluXl;t;sasb ;oi s;6sb lXam; mssaamslmo (Xsll(slamlmsb sXlunluu 
aslm )

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





  aX sb sXluxL Ulm6 Xslmaox msslamX TolX LX Uouslam;nluu (Xakl L
sb 
mk ;slUsaX)b X TolX aox msslamnluu t (sLsb (am;aX)

aox ms;sxlmlxoxX TolX sa Ulmsb sXlulmuo 6osX masulxls sa6sb  auuanlmU3

•
;lUmsoX cosbaXlF (XasaaumamsXs0
•
a(La sb a  llu
((Xakua sb sXlumsb 
x x X;ul;s0
•
oXX msoXXlouls aXsb (Xlml(ulmk ;slUsaXmmL;;als lmk ;slUsaXC;Dnba
nluu lmkauk lmsb sXlu0
•

mlslama ((Xa(Xls X lsslam aXmLuaXsaXl ;sa o; lmsb sXlum
a(La sb maXxuXmU ; aXs ;s;sa ( X aXx LsbsuaXsaXL0
•
XlUlmuaXx9WG%Css x msa 
mk ;slUsaXD6((Xa(Xls uLax(u s m;lUm 0
•
a(La sb 
c((Xak am; ms aXxamslmlmU( Xxl;;lam aXolsLsb abm;
	a(tlm;
mfaXsb 0
•
lmmlul;ua;oX  aXx; aXuulmk ;slUsaX;ul;s amaXx9WG%0
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 Xsl ls  aXsXlusXlmlmU0
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ls Toul lslamX (aXs;6nb X ((ulu 0


•
 Xl lslama Xlml(u
mk ;slUsaX (slulsL XaxuaumfaXmslamu Xx ms
ul;sC;D)

b (am;aXnluu m;oX sbsuuaox msslamsbsl;X TolX sa lm(u   aX sb sXluxL
;sXs6lmaXm nlsb
	Em(am;aX;6nluu kluu   aX mLsXlu;ls ;X 
lmlsls )
0Vop


b 
nluuxlmslmul;sa ((Xa(Xls uLToul l ( X;am;sanbaxb f;b b; u Us sXlu
osl ;mnluu m;oX sbsuu( X;am;;;l;slmUlmsb amosa sb sXluX lm aXx a sb lX
aulUslam;)uu( X;am;osbaXlF saxt  msXl ;mfaXaXX slam;amsb ;nluu lmuo 
amsbl;aox ms)uu msXl ;lmsb ;oi sh;nluu ;o((aXs L;aoX aox msslamnb X 
((Xa(Xls )

aoX aox ms;X sb aXlUlmuaox ms;6s6X aX;m Xsl l a(l ;a aXlUlmuX aX;
a ulmlu lmlmU;6a; Xkslam;mslklsl ; Xaxnblbsb ;oi sh;sX aslm )
b ; mlmuo 6osX masulxls sa6ba;(lsuX aX;6ulmluma  l bXs;6uaXsaXL6
x lacs bmlu (Xsx msm(bXxLX aX;6lXl ;6xlXa lb ;6sX ;6a(l ;aX
sXm;Xl(slam; Xsl l  s Xk Xl lslam; lmUoXs max(u s 6(basaUX(blm Uslk ;6
xlXa luxaXxUm slx l6cXL;6maXX ;(am m )

b 
msXlu;s  X X ;(am;lu  aXxlmslmlmUax(X b m;lk m msXulF  lulmU;L;s x
Cls Xlulu faX
Da uusXlucX us C ;; msluDaox msslam6;olsu  aXlm;( slams
mLslx LX (X ; msslk ;a ((ulu X UousaXLosbaXlsl ;)b 
fxo;sam;l;sa sba; 
aox ms;sbslmlklouuLaXauu slk uL( Xxls kuoslama sb amosa sb sXlumsb 
ToulsLa sb s(Xao )b 
fnluuamslm;xlmlxoxuuX u kmsaox ms;m
aXX ;(am m ;aosulm lm
	 slam98m%9Xs89%)WG6lmuolmUt L
aox ms;;ob;sb 
mmLx mx ms;6(XasaaummLx mx ms;6;lUm 
;6a(l ;
a ax(u s ;6
((Xakuaox ms;6lmmlul;ua;oX  aXx;6;oi sl msl lslamul;s;6
 mXauux msuaU;6 u Uslama osbaXlsLuaU6;s  Toul lslamaox ms;6uaXsaXLmaXxu
XmU ;6X aX;X uslmUsasb sXluXoUlmuolmUaomslulsLX aX;)XoUaomslulsL
X aX;nluu6sxlmlxox6amslmlm aXxslamX UXlmUX  l(s6;bl(x ms6ml;(a;lslam)b
 aXxa XoUaomslulsLX aX6sxlmlxox6nluuamslm
mx 6s XoU
;bl(( fX  lk 6s 6TomslsLmsbfa 6aXuasmox X aXl mslsLa  b;bl(x ms)
m
lslam6uuaXlUlmu;aoX aox ms;;o((aXslmU msXl ;lmsb nluu xlmslm m 
X luLkluu )

b (am;aXflmk ;slUsaXCX) kLDnluuxlmslm Tos lmk ;slUslamu(XaosX aX;m
 lmmlulms X ;sX aX;;( X%9XsW+)EmXs89%)WG aXmau ;;sbm%L X; s Xsb 
u;sxXt slmU((ulslamb;  m((Xak L0aX6lmsb  k mssbssb xXt slmU
((ulslamb;mas  m((Xak L6 aXmau ;;sbm%L X; s Xsb u;s;bl(x msf
 ulk XLa sb XoU aXlmk ;slUslamuo; l;l;amslmo mb;  mmasl l a sb 
l;amslmoslam)

b 
;buuxlmslm Tos aox msslamfX aX;a 
slklsl ;;( X%9
XsWE)99W aXsu ;s8L X; s Xax(u slama sb X ; Xb)

a mu  kuoslam;mfaXols; XaxX UousaXLosbaXlsl ;6sb lmk ;slUsaXlslamuuLnluu
t  (X aX;6lmuolmUsb l mslsLa uu(Xsll(slmU;oi s;C;o  ll mslm aXxslamsaulmt
X aX; )U)6x luX aX;D6uuaXlUlmu6;lUm lm aXx am; ms aXx;6ma(l ;a uu;66
;aoX aox ms;6 slu X aX;a sX sx msl;(a;lslam6mX us  ;; msluX UousaXL
aox ms;)b aox ms;ul;s ak nluu X slm Lsb lmk ;slUsaX aX;uamU;m   
saax(uLnlsbmslamumlms XmslamuX Uouslam;CU m XuuL%L X; s Xl;amslmolmUulmlu


 k ua(x msaX s Xsb u;sxXt slmU((XakuD)b X( osl;aXls;X (X ; msslk nluu
masl LX) kLCaXabm;	a(tlm;mlk X;lsLDnb msb sXlucX us X aX;X mauamU XX TolX )

0Vox

b sXlul;sb (XlxXLsauu slamlm;sXox ms aXsb sXlu); X (aXs aXxCDnluu 
oslulF  aXsb auu slama uusmuusnluu  ms X o;lmUsb mUul;bumUoU m
;baou t (soXX mssa mu sb xamlsaXsaX kl nsb ;oi s;h;sso;sbXaoUbaossb aoX; a 
sb sXlu)


maX Xsaxlmslmam l mslulsL6amuLsXlumox X6;oi smox X6lmlslu;ms a lXsb
xL o; sal msl Lsb ;oi slmsb )
 sb ;oi sh;mx (( X;ammLasb X
aox msC )U)uaXsaXLX (aXsD6lsnluu auls Xs amsb a(La sb aox mssa ;o((ul 
sasb lmk ;slUsaX;ls mX (u lm;s nlsbsb ;oi smox Xm;oi sh;lmlslu;)b 
lmk ;slUsaXnluuxlmslm( X;amu;oi sl msl lslamul;sC;oi smox X;nlsb
aXX ;(amlmU;oi sl msl l X;Dsa mu X aX;sa l msl l mk Xl l ;osb msl)
oi ssflm aXxslamnluu t (sam l mslu6mnluu xmU aXlmUsa((ulu 
uau6;ss 6m   XuX Uouslam;)
0VoJ


t

t


b lmk ;slUsaXnluu( XxlssXlucX us xamlsaXlmU6ToulsLols;6mlm;( slam;L
b X( osl;mUak Xmx msX UousaXLosbaXlsl ;a uusXlucX us aox ms;C )U)6;aoX 
aox ms;6X UousaXLaox ms;6sauu slamlm;sXox ms;6; X (aXs aXx;D)b 
lmk ;slUsaXnluu m;oX sb (lulsL aXlm;( slam;a ((ulu sXlucX us  lulsl ;)b 
lmk ;slUsaXnluu m;oX sbssb sXluxamlsaXaXmLasb Xax(ulm aXX kl n Xl;Ulk m
 ;;sauusXlucX us aox ms;msXlucX us  lulsl ;)

Xsll(slam;mlmk ;slUsaXlmsbl;sXlulx(ul ;sb  (sm a (as mslulm;( slamL
Uak Xmx msX UousaXLosbaXlsl ;6sb ;(am;aXaXls;X (X ; msslk C;D)

ssb (am;aXh;l;X slamaoX aox ms Xl lslamCDxL ( X aXx amuusls x;
aX( X msU sb X a )
0VoV



mlslamsasb ulmluamlsaXlmUax(am msa sbl;(Xasaau6sb b X( osl;h;oulsL
;;oXm CD (Xsx ms;buu ;sul;bmolslmUumaox ms; (Xs  Xaxsb (Xasaau
sa ;sul;bsb Xls XlLnblblm ( m msolslmU;buu amos oXlmUsb amosa sb 
sXlusa;; ;;ax(ulm nlsbm((ulu X UousaXLX TolX x ms;)saX
aox msslamols ;buu ;; ;;  aXax(ulm sasb (Xasaau6oXLlmX uslamsa
;aoX aox ms;max(ulm sa((ulu X Uouslam;)
0VoP




uulm aXxslam(Xakl X UXlmUsb sXlu6;n uu;uulm aXxslamauu s faox ms 
oXlmUsb aoX; a sb sXlu6nluu X UX ;am l mslu)

ulmlusXluX (aXsnluu (X (X o(amax(u slama sb sXlu)b (am;aXnluul;ua; sb 
sXluX ;ous;6lmsb  aXxa ulmlusXluX (aXs;Lma(;l;6sasb 
msb ((ulu X UousaXL
osbaXlsl ;nlsblmam L Xa sb  ma sb sXlu)b  aXxsa sbl;;Lma(;l;msbsa sb 
ulmlusXluX (aXsmls; moxnluuax(uLnlsb
	8Uol ulm ; aX;sXosoX mams ms
a ulmlusXluX (aXs)



b  lmmlul;ua;oX lm aXxslamnluu (Xakl sab X( osl;msb abm;	a(tlm;

(XlaXsasXlu(Xsll(slam Xaxuu
;moc
mk ;slUsaX;nbaX lmkauk lmsb sXlum
mx amsb 9WG% aXx

LamoslmUsbl;sXlu6sb 
mk ;slUsaX  lXx;sab X( osl;sbsb aX;b nluuxlmslm6lm
;sXlsam l m 6lm aXxslam oXml;b Lb X( osl;lmuolmUsU m Xs  Xaxsbl;sXlu
m(X ulxlmXLuaXsaXLX ;ous;6 w (s; w x(s  aXX UousaXL(oX(a; ;)


uusU m Xs oXlmUsb amosa sbl;sXlul;anm Lsb (am;aXCX) kLDmxL 
;bX nlsbb X( osl;;aosulm lm; (Xs amsXs sn  mb X( osl;mabm;
	a(tlm;)

uuxmo;Xl(s;6;sXs;6aXasb X(X ; msslamxs Xlu;m U m Xs ssb l;X slama sb 
(am;aXCX) kLD)


0P
us X6oL6	  Xs su)6 s Xxlmms;a 	oxm uulUXslamXa;;Xlmmasb ulu
 uu;6
	eenit %®®89G®CSD3++SGc+W®W

Xlstl6luls uua6u(ams 6(mla;6u a6amkl)b mslc%®x
oulsowlxlms XXo(s;sb L;X Uous ct((fmluf
fX ;l;sm uaa(lmc	
 uu;3Xau lm; m;lslFslamsa
(a(sa;l;)
msmau)%®9908ICED39EI8cS+

 l6 su)6
x(sa XlsowlxamX u(; Xs ml;lulsLlmm oXaxL ulsl;a(sl
n Ih  rt((
tnri 9GC9®D9%%Wr9%8®

lFFaa6auul6 (l 6 su)X ku m a m oXaxL ulsl;a(sl;( sXoxl;aX Xm
(b masL( l;sXloslam)
nrt %®®S0%WE39IS9r9ISI

u  t X6omt6to; su)6;slxslama a; X TolX x ms; aX;o;sslm iaat
slklsLa sb X( oslboxmmslc%®mslaL6r
xeIt t %®®G39+®38®8c89%

o Xt )6oXabX)6   X))Xla(Xas slk     s;a 9 ;s X; lmbllsaXlmxLaXlu
l;b xlmX ( X o;lam)rn Iti9SSW0S938S8c+®%

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ua(( X6m X;am)b o; a am l m aX loluulxls;luuo;sXs lmsb ; a sb 
lmaxlu)teIr69S8+0%E3((+®+c+98

aat6lmittten Ih ( rt((c )aat%®®E6+sb m)6LuaX-Xml;3 naXt

X  6x6aXUm6b m6oms6 mlm)6m( m usoLa sb    s;a 
lsowlxlm oXaxL ulsl;(sl)nrt t %®®W0E+39%G®r9%G%

 ax o 6os XsX 6 X  ck Xml X6aoXml X6ob X6u s6 su)bXaml
uLx(baLslu ot xl uu;X    ll msuLtluu Lmmslc%®xamauamumslaL; u s  aX
lx(Xak  mUU x msa Uxx


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mslaLl;(uL;mlslk mslsoxaXslklsLnlsbmslu ot xlb xasb X( oslU ms;lm
ao;  maUX sa u;)x Xlmal sLa ulmlumauaUL%®99a;s XX ; msslam

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xLaXlulm Xslamlm(sl ms;nbaom Xn ms;oXUluX ( X o;lam3Xmaxl; aou ulm
;soL)nr
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UlmlmUsans Xbmm u
 wsX uuouXaxlmlmm oXaxL ulsl;a(sl6nrt t %®®G0ES3%%%9c%%89

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6
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ICF_001.pdf: 
Brief Title: Ublituximab for Acute Neuromyelitis Optica (NMO) Relapses 
 
Document Date: September 3, 2015  
 
Document: Informed Consent Form 
 
ClinicalTrials.gov ID: NCT02276963 


 
Approved September 3, 2015 
Date: September 3, 2015 
Principal Investigator: Levy, Michael 
Application No.: IRB00052958 
 
Page 1 of 10 
Combined Informed Consent/Authorization June 2015 Version 15 
 
 
 
 
 
 
 
 
 
 
RESEARCH PARTICIPANT INFORMED CONSENT AND PRIVACY 
AUTHORIZATION FORM 
 
Protocol Title:  
Phase I, Open Label Safety Study of Ublituximab for the Treatment of 
Acute Optic Neuritis and/or Transverse Myelitis in Neuromyelitis 
Optica (NMO) and Neuromyelitis Optica Spectrum Disorder 
(NMOSD) 
 
Application No.: 
IRB00052958 
 
Principal Investigator: Michael Levy, MD, PhD 
Assistant Professor, Johns Hopkins University 
Director of Neuromyelitis Optica Clinic 
1800 E. Orleans St. 
Pathology 509 
Baltimore, MD 21287 
443-287-4412 phone 
443-287-4062 fax 
  
 
1. 
What you should know about this study:   
x You are being asked to join a research study. This consent form explains the research study and your 
part in it. Please read it carefully and take as much time as you need. Ask your study doctor or the 
study team to explain any words or information that you do not understand. 
x You are a volunteer.  If you join the study, you can change your mind later.  There will be no penalty 
or loss of benefits if you decide to quit the study.   
x During the study, we will tell you if we learn any new information that might affect whether you 
wish to continue to participate. 
x If we think your participation in this study may affect your clinical care, information about your 
study participation will be included in your medical record, which is used throughout Johns Hopkins.   
Doctors outside of Johns Hopkins may not have access to this information.  You can ask the research 
team to send this information to any of your doctors. 
x When Johns Hopkins is used in this consent form, it includes The Johns Hopkins University, The 
Johns Hopkins Hospital, Johns Hopkins Bayview Medical Center, Howard County General Hospital, 
Johns Hopkins Community Physicians, Suburban Hospital, Sibley Memorial Hospital and All 
Children’s Hospital.  
If you are using Epic for this study, fax a copy 
of the signed consent form to 410-367-7382. 
 
 
 
 
 
Patient I.D. Plate 
                                 


 
Approved September 3, 2015 
Date: September 3, 2015 
Principal Investigator: Levy, Michael 
Application No.: IRB00052958 
 
Page 2 of 10 
Combined Informed Consent/Authorization June 2015 Version 15 
x Biospecimens will be collected in this study.  Biospecimens may include any of the following: 
blood, tissue, saliva, urine, bone marrow, cells, etc.  Most biospecimens contain DNA, which is the 
genetic code for each person. 
x A description of this clinical trial will be available on http://www.ClinicalTrials.gov, as required by 
U.S. Law.  This Web site will not include information that can identify you. At most, the Web site 
will include a summary of the results. You can search this Web site at any time.  
x If you would like to review the information for this study, or a summary of the results, ask the study 
team doctor for the ClinicalTrials.gov study registration number. 
 
2. 
Why is this research being done? 
This research is being done to study the safety of the investigational drug ublituximab (UTX) when used 
as an add-on therapy to standard of care for the treatment of acute optic neuritis and/or transverse 
myelitis in people with neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorders 
(NMOSD). We will also be looking at the effects of UTX on your neurological status.  
 
High dose steroids are the first line standard of care treatment for acute NMO/NMOSD attacks.  
Ublituximab (UTX) is a monoclonal antibody that causes lysis (destruction) of B cells. We want to find 
out what effects (good and bad) people experiencing these attacks get when they take ublituximab in 
addition to the standard of care and if it is effective in reducing the inflammation and damage in the 
spinal cord and/or optic nerves during an attack. 
 
Ublituximab is not approved by the Food and Drug Administration (FDA) for use in NMO or NMOSD 
and therefore its use in this study is investigational.  The FDA is allowing the use of ublituximab in this 
research study. 
 
We will assess the safety and compare the clinical and radiographic outcomes following acute optic 
neuritis and/or transverse myelitis in NMO/NMOSD in patients who receive 1 dose of 450 mg of 
ublituximab in addition to standard medical therapy. 
 
We hope to determine the: 
o safety and tolerability of 1 dose of 450 mg ublituximab given by infusion into a vein 
o frequency of adverse events with ublituximab in this patient population with NMO/NMOSD 
o effect of ublituximab on NMO/NMOSD neurological function after relapse 
o effect of ublituximab on Magnetic Resonance Imaging (MRI) lesion size and extent. 
 
People aged 18-100 years, diagnosed with NMO or NMOSD and experiencing optic neuritis and/or 
transverse myelitis may join. 
 
How many people will be in this study? 
About 5 people are expected to take part in this study. 
 
3. 
What will happen if you join this study? 
If you agree to be in this study, we will ask you to do the following things: 
 
First, you will be started on treatment for your attack according to standard of care. That involves five 
(5) daily infusions of high dose steroids (1000 mg of methylprednisolone) intravenously. Steroids are 
the first line treatment for acute NMO attacks.  
 
In addition to high dose steroids, if you join this study, you will receive 1 dose of ublituximab (450 mg) 
by infusion into a vein on the first day of your treatment. You will not receive any further ublituximab 


 
Approved September 3, 2015 
Date: September 3, 2015 
Principal Investigator: Levy, Michael 
Application No.: IRB00052958 
 
Page 3 of 10 
Combined Informed Consent/Authorization June 2015 Version 15 
during your hospitalization. If you received steroid treatment for this relapse prior to transfer to Johns 
Hopkins, you will complete your 5-day steroid course and receive ublituximab on the first day of 
hospitalization at Johns Hopkins.  
 
Every day that you are in the hospital receiving treatment for this NMO/NMO exacerbation, you will 
have a neurologic examination, as per standard of care. If you join this study, there will be additional 
neurologic examinations that will take place at the bedside. These include timed walking and basic 
vision tests.  
 
At the end of the 5 doses of steroids, your doctors will evaluate you to see if they need to escalate your 
treatment to plasma exchange, according to standard of care. The decision to escalate your care is made 
by considering your improvement in muscle strength, sensory function and bowel/bladder control. 
 
If your doctor decides not to escalate your care: 
If you have improved to the point that you do not need plasma exchange in your doctor’s opinion, a 
Magnetic Resonance Imaging (MRI) may be performed as part of your standard of care, to confirm that 
your exacerbation has been effectively treated.  
 
Based on the MRI, your doctor may discharge you home or change the plan to escalate your care.  
 
Typically, 33 - 50% of NMO/NMOSD patients improve from a relapse with just steroids alone. The 
other 50 - 66% require escalated care with plasma exchange.  
 
If your doctor decides to escalate your care: 
If your doctor decides to escalate your care to plasma exchange, you will receive plasma exchange 
according to standard of care practice for NMO relapses. You will not receive any additional doses of 
ublituximab.  
 
At the end of your plasma exchange therapy, your doctor will make another decision about your 
progress, again perhaps aided by a standard of care MRI. If your doctor notes improvement, you may be 
discharged from the hospital.  
 
Typically about 95% of NMO/NMOSD patients who complete plasma exchange are discharged 
following completion of the plasma exchange. The other 5% require escalated care with additional 
immunosuppression. 
 
Follow-up Visits: 
Before discharge from the hospital, two appointments for follow-up outpatient clinic visits will be 
made—one visit 90 days (3 months) from discharge and one visit 180 days (6 months). At the 90 day 
visit, you will obtain a research MRI similar to the MRI scans obtained at the hospital. At both clinic 
visits, you will undergo repeat neurological and visual testing to assess changes that may have taken 
place since discharge.  
 
Also, every month after discharge, you will obtain a blood test for the CD19/20 B cell marker, complete 
blood count and liver function tests at your local lab. The results will be automatically sent to us for 
review. You will need to repeat this monthly blood test until your B cells begin to repopulate, which 
could take up to 9 months or perhaps longer.  
 
Incidental Findings:  


 
Approved September 3, 2015 
Date: September 3, 2015 
Principal Investigator: Levy, Michael 
Application No.: IRB00052958 
 
Page 4 of 10 
Combined Informed Consent/Authorization June 2015 Version 15 
One of the MRIs you are having 90 days after hospitalization as part of this research study will be 
reviewed by a qualified person just as it would be if you were having the MRI as part of your routine 
medical care.  
 
There is a possibility that while reviewing MRI we may see an abnormality that we did not expect to see 
in this study. This is what is called an "incidental finding."  
 
We will let you know if we see such an incidental finding. Depending on the type of incidental finding, 
we may contact you by mail or by phone. In the case of a potential serious emergency, someone may go 
to your home.  
 
A qualified person (usually a member of the research team) will talk to you if there is an incidental 
finding. You do not have an option to decline information about an incidental finding. 
 
If you want, we will give information about this incidental finding to your primary doctor or we will 
refer you to an appropriate doctor for further evaluation. 
• 
An incidental finding may cause you to feel anxious.  
• 
Since an incidental finding will be part of your medical record, it may affect your current or future 
life or health insurance coverage. This risk will vary depending on the type of insurance plan 
involved.  
 
The costs for any care that will be needed to diagnose or treat an incidental finding would not be paid for 
by this research study. These costs would be your responsibility. 
 
How long will you be in the study? 
You will be in this study for up to 9 months or perhaps longer. The first 5-15 days are in the hospital. 
The rest of the time, you will be at rehabilitation or home.  
 
4. 
What are the risks or discomforts of the study? 
Possible side effects of ublituximab listed below are based on studies of ublituximab in humans.  These 
side effects may be a minor inconvenience or could be severe enough to be life threatening or fatal.  In 
addition, there is always the risk that you could experience other presently unknown side effects.  You 
will be watched closely for any side effects and if serious side effects occur the drug will be stopped and 
you will be treated appropriately.  
Below are the most common risks of ublituximab reported in humans. For the most part, most of these 
are short-term risks lasting a few days to a few weeks. The most important long term risk lasting up to 9 
months risk of infections due to immunosuppression.  
 
It possible that getting plasma exchange soon after ublituximab administration may reduce the possible 
effectiveness of ublituximab. 
 
Very Common (greater than or equal to 10%) 
x Blood and lymphatic system disorders: Neutropenia (low white blood cell levels), 
Thrombocytopenia (low blood platelet count) 
x Gastrointestinal disorders:  Nausea 
x General disorders and administration site conditions: Fever, allergic reactions such as rash, low 
blood pressure, shortness of breath,, Asthenia (weakness), Chills 
x Infections and infestations: Bronchitis, Nasopharyngitis (inflammation of nasal passages and 
throat), Rhinitis (inflammation of mucous lining of the nose), Sinusitis (inflammation of the sinuses), 
Oral herpes 


 
Approved September 3, 2015 
Date: September 3, 2015 
Principal Investigator: Levy, Michael 
Application No.: IRB00052958 
 
Page 5 of 10 
Combined Informed Consent/Authorization June 2015 Version 15 
x Investigations: Liver test abnormalities 
x Nervous system disorders: Headache 
x Respiratory, thoracic and mediastinal disorders: Cough 
 
Common (greater than or equal to 1% and less than 10%) 
x 
Blood and lymphatic system disorders: Anemia, Pancytopenia (low levels of all blood cells), 
Febrile neutropenia (fever with other signs of infection), Autoimmune hemolytic anemia (a 
condition in which the immune system attacks the red blood cells, resulting in fewer of these 
oxygen-transporting cells), Anemia (low blood cell count), Evans syndrome (an autoimmune disease 
in which an individual's antibodies attack their own red blood cells and platelets) 
x Cardiac disorders: Cardiac flutter, arrhythmia 
x Ear and labyrinth disorders: Tinnitus (noise or ringing in the ears) 
x Endocrine disorders: Thyroid cyst 
x Eye disorders: Conjunctivitis (inflammation or infection of the transparent membrane (conjunctiva) 
that lines the eyelid and covers the white part of the eyeball), Lacrimation (shedding of tears) 
decreased 
x Gastrointestinal disorders: Lip edema (swelling), Gingival (gum) bleeding, Oral paresthesias 
(mouth tingling/numbness), Stomatitis (swelling of mouth or lips), Esophagitis (inflammation or 
irritation of the esophagus), Abdominal pain, Upper Abdominal pain, Gastric ulcer, Constipation, 
Colonic polyp, Diverticulitis (inflammation of the large bowel), Diarrhea 
x General disorders and administration site conditions: Chest pain, Fatigue, Injection site 
hemorrhage, Swelling in the arms and legs 
x Hepatobiliary disorders: Cholestasis (decrease in bile flow), Cholecystitis acute (inflammation of 
the gallbladder), other forms of liver injury and toxicity. 
x Immune system disorders: Drug hypersensitivity, Hypogammaglobulinemia (immune deficiency 
disease) 
x Infections and infestations: Influenza, Lung infection, Upper respiratory tract infection, Tracheitis, 
Laryngitis, Tonsillitis, Parotitis (inflammation of salivary glands), Otitis media (inflammation of 
middle ear), Urinary tract infection, Anal abscess, Bronchopulmonary aspergillosis (allergic lung 
reaction), Febrile infection, Listeriosis (bacterial infection), Septic shock, Staphylococcal sepsis, 
Streptococcal sepsis, Hepatitis C, Genital herpes, Herpes zoster,  
x Injury, poisoning and procedural complications: Wrong technique in drug usage process, 
Subcutaneous hematoma (bruise) 
x Investigations: Weight decreased, Serum IgA increased, O2 saturation decreased 
x Metabolism and nutrition disorders: Diabetes mellitus inadequate control, Hypercholesterolemia, 
Hyperglycemia, Hyperuricemia (excessive uric acid in blood) 
x Musculoskeletal and connective tissue disorders: Back pain, Musculoskeletal pain, Muscle 
spasms, Myalgia (muscle pain), Arthralgia (joint pain), Tendonitis  
x Neoplasms benign, malignant and unspecified (including cysts and polyps): Squamous cell 
carcinoma, Basal cell carcinoma, Leukemia, Neuroendocrine carcinoma of the skin 
x Nervous system disorders: Somnolence (sleepiness), Paraesthesia (burning or prickling sensation), 
Syncope vasovagal (fainting), Ischemic stroke 
x Psychiatric disorders: Anxiety, Aggression, Depression, Insomnia 
x Renal and urinary disorders: Hematuria (blood in urine) 
x Reproductive system and breast disorders: Genital prolapse, Vulva cyst 
x Respiratory, thoracic and mediastinal disorders: Epistaxis (nosebleed), Throat irritation, 
Bronchopneumopathy (type of pneumonia) 


 
Approved September 3, 2015 
Date: September 3, 2015 
Principal Investigator: Levy, Michael 
Application No.: IRB00052958 
 
Page 6 of 10 
Combined Informed Consent/Authorization June 2015 Version 15 
x Skin and subcutaneous tissue disorders: Erythema (redness of skin), Urticaria (hives), Allergic 
dermatitis, Perivascular dermatitis (skin irritation associated with inflammation around the blood 
vessels), Skin hemorrhage, Hyperhidrosis (excessive sweating), Night sweats 
x Vascular disorders: Hypertension (high blood pressure), Hypotension (low blood pressure), Hot 
flush 
 
 
Should you develop these reactions during the study, we will make every effort to treat you. 
 
Infusion Process:  
The most common risks related to the infusion process include fever, infection at the infusion site, 
clotting or swelling at the infusion site, accidental infusion into the tissue around the vein. 
 
Confidentiality:  
There is the risk that information about you may become known to people outside this study. 
 
We will make every effort to maintain confidentiality of your personal medical information by keeping 
all data on password-protected computers and files and minimizing use of paper records. 
 
5. 
Are there risks related to pregnancy? 
This research may hurt an embryo or fetus and affect reproduction capacity in ways we do not currently 
know.   
 
Women who are pregnant may not participate in this study.  If you are able to have children, you will 
have a pregnancy test at screening.  This test must be negative in order for you to take part in this study. 
 
6. 
Are there benefits to being in the study? 
There may or may not be a direct benefit to you from being in the study.  
 
If you take part in this study, you may help others in the future. 
 
7. 
What are your options if you do not want to be in the study? 
If you decide not to join this study, other options are available.  You do not have to join this study to get 
treatment.  The treatment you will receive if you do not join this study will be the standard of care 
treatment of high dose steroids (1000 mg methylprednisone daily) intravenously and, if necessary, 
plasma exchange.  
 
You do not have to join this study.  If you do not join, your care at Johns Hopkins will not be affected. 
 
8. 
Will it cost you anything to be in this study? 
It will not cost you anything to be in this study.  
 
You will receive a separate Insurance and Research Participant Financial Responsibility Information 
Sheet (Sheet).  
 
This Sheet will give you the following information: 
 
x The procedures, tests, drugs or devices that are part of this research and that will be paid for by 
the study (no cost to you).   
 


 
Approved September 3, 2015 
Date: September 3, 2015 
Principal Investigator: Levy, Michael 
Application No.: IRB00052958 
 
Page 7 of 10 
Combined Informed Consent/Authorization June 2015 Version 15 
x The procedures, tests, drugs or devices that will be billed to you and/or your health insurer.  If 
you have health insurance, you will be responsible for any co-pays or deductibles not covered by 
your insurance. 
 
9. 
Will you be paid if you join this study? 
No. 
 
10. 
Can you leave the study early? 
x You can agree to be in the study now and change your mind later. 
x If you wish to stop, please tell us right away. 
x Leaving this study early will not stop you from getting regular medical care.  
x If you leave the study early, Johns Hopkins may use or give out your health information that it 
already has if the information is needed for this study or any follow-up activities. 
 
11. 
Why might we take you out of the study early? 
You may be taken out of the study if: 
x Staying in the study would be harmful. 
x You need treatment not allowed in the study. 
x You fail to follow instructions. 
x You become pregnant. 
x The study is cancelled. 
x Join an additional medical research study during this time.  
x There may be other reasons to take you out of the study that we do not know at this time.  
 
If you are taken out of the study early, Johns Hopkins may use or give out your health information that it 
already has if the information is needed for this study or any follow-up activities. 
 
12. 
How will your privacy be protected?  
 
We have rules to protect information about you.  Federal and state laws and the federal medical Privacy 
Rule also protect your privacy.  By signing this form you provide your permission, called your 
“authorization,” for the use and disclosure of information protected by the Privacy Rule. 
 
The research team working on the study will collect information about you.  This includes things learned 
from the procedures described in this consent form.  They may also collect other information including 
your name, address, date of birth, and information from your medical records ([which may include 
information about HIV, drug, alcohol or STD treatment, genetic test results, or mental health treatment). 
 
The research team will know your identity and that you are in the research study.  Other people at Johns 
Hopkins, particularly your doctors, may also see or give out your information. We make this information 
available to your doctors for your safety.    
 
People outside of Johns Hopkins may need to see or receive your information for this study.  Examples 
include government agencies (such as the Food and Drug Administration), safety monitors, other sites in 
the study and companies that sponsor the study. If you are in a cancer study that receives federal 
funding, the National Cancer Institute (NCI) now requires that we report identifiable information (such 
as, zip code) about your participation.  You may contact the NCI if you have questions about how this 
information is used.  
 


 
Approved September 3, 2015 
Date: September 3, 2015 
Principal Investigator: Levy, Michael 
Application No.: IRB00052958 
 
Page 8 of 10 
Combined Informed Consent/Authorization June 2015 Version 15 
We cannot do this study without your authorization to use and give out your information.  You do not 
have to give us this authorization.  If you do not, then you may not join this study. 
 
We will use and disclose your information only as described in this form and in our Notice of Privacy 
Practices; however, people outside Johns Hopkins who receive your information may not be covered by 
this promise or by the federal Privacy Rule.  We try to make sure that everyone who needs to see your 
information keeps it confidential – but we cannot guarantee that your information will not be re-
disclosed. 
 
The use and disclosure of your information has no time limit. You may revoke (cancel) your permission 
to use and disclose your information at any time by notifying the Principal Investigator of this study by 
phone or in writing.  If you contact the Principal Investigator by phone, you must follow-up with a 
written request that includes the study number and your contact information.  The Principal 
Investigator’s name, address, phone and fax information are on page one of this consent form.  
 
If you do cancel your authorization to use and disclose your information, your part in this study will end 
and no further information about you will be collected. Your revocation (cancellation) would not affect 
information already collected in the study, or information we disclosed before you wrote to the Principal 
Investigator to cancel your authorization. 
 
13. 
Will the study require any of your other health care providers to share your health 
information with the researchers of this study?    
As a part of this study, the researchers may ask to see your health care records from your other health 
care providers in order to verify your diagnosis of NMO/NMOSD. You will be asked to give us a list of 
other health care providers that you use.  
 
14. 
What treatment costs will be paid if you are injured in this study?  
Johns Hopkins does not have a program to pay you if you are hurt or have other bad results from being 
in the study.  However, medical care at Johns Hopkins is open to you as it is to all sick or injured people.   
 
TG Therapeutics, manufacturer of ublituximab, will cover costs associated with injury due to use of the 
drug in this trial.  
 
15. 
What other things should you know about this research study? 
a. What is the Institutional Review Board (IRB) and how does it protect you?  
The Johns Hopkins Medicine IRB is made up of: 
x Doctors 
x Nurses 
x Ethicists 
x Non-scientists 
x and people from the local community.  
 
The IRB reviews human research studies. It protects the rights and welfare of the people taking part 
in those studies.  You may contact the IRB if you have questions about your rights as a participant or 
if you think you have not been treated fairly.  The IRB office number is 410-955-3008. You may 
also call this number for other questions, concerns or complaints about the research. 
 


 
Approved September 3, 2015 
Date: September 3, 2015 
Principal Investigator: Levy, Michael 
Application No.: IRB00052958 
 
Page 9 of 10 
Combined Informed Consent/Authorization June 2015 Version 15 
When the Johns Hopkins School of Medicine Institutional Review Board (IRB) reviews a study at 
another site, that site (institution) is solely responsible for the safe conduct of the study and for 
following the protocol approved by the Johns Hopkins IRB.   
 
b. What do you do if you have questions about the study?    
Call the principal investigator, Dr. Michael Levy at 443-287-4412 (office). If you wish, you may 
contact the principal investigator by letter or by fax. The address and fax number are on page one of 
this consent form.  If you cannot reach the principal investigator or wish to talk to someone else, call 
the IRB office at 410-955-3008.  
 
c. What should you do if you are injured or ill as a result of being in this study?  
If you think you are injured or ill because of this study, call Dr. Michael Levy at 443-287-4412 
during regular office hours.  
 
If you have an urgent medical problem related to your taking part in this study, call Dr. Michael 
Levy at 443-287-4412 during regular office hours and at 410-979-8297 (cell) after hours and on 
weekends.  
 
d. What happens to Data and Biospecimens that are collected in the study?  
Johns Hopkins and our research partners work to understand and cure diseases.  The biospecimens 
and/or data you provide are important to this effort. 
 
 
If you join this study, you should understand that you will not own your biospecimens or data, and 
should researchers use them to create a new product or idea, you will not benefit financially.  
 
With appropriate protections for privacy, Johns Hopkins may share your biospecimens and 
information with our research sponsors and partners.    
 
 


 
Approved September 3, 2015 
Date: September 3, 2015 
Principal Investigator: Levy, Michael 
Application No.: IRB00052958 
 
Page 10 of 10 
Combined Informed Consent/Authorization June 2015 Version 15 
 
16. 
What does your signature on this consent form mean?  
Your signature on this form means that: You understand the information given to you in this form; you accept the 
provisions in the form and you agree to join the study. You will not give up any legal rights by signing this 
consent form.  
WE WILL GIVE YOU A COPY OF THIS SIGNED AND DATED CONSENT FORM 
 
 
________________________________________________________________________________________________________________________ 
Signature of Participant                                                                           (Print Name)                                                 
 
Date/Time  
 
 
________________________________________________________________________________________________________________________ 
Signature of Person Obtaining Consent                                                  (Print Name)                                               
 
Date/Time 
 
 
 
I have received the separate Insurance and Research Participant Financial Responsibility Information Sheet.   
 
___________________________________________________________________________________________________________ 
Signature of Participant, LAR or Parent/Guardian                               (Print Name)                                                        Date/Time 
 
NOTE: A COPY OF THE SIGNED, DATED CONSENT FORM MUST BE KEPT BY THE PRINCIPAL INVESTIGATOR; A COPY MUST BE GIVEN 
TO THE PARTICIPANT; IF YOU ARE USING EPIC FOR THIS STUDY A COPY MUST BE FAXED TO 410-367-7382; IF YOU ARE NOT USING EPIC 
A COPY MUST BE PLACED IN THE PARTICIPANT’S MEDICAL RECORD (UNLESS NO MEDICAL RECORD EXISTS OR WILL BE CREATED).  
 
ONLY CONSENT FORMS THAT INCLUDE THE JOHNS HOPKINS MEDICINE LOGO CAN BE USED TO OBTAIN THE CONSENT OF RESEARCH 
PARTICIPANTS.