Clinical trial NCT00572455
Conditions: Primary Open-Angle Glaucoma Ocular Hypertension
Keywords: Open-Angle Glaucoma Ocular Hypertension
Sponsor: Pfizer
Start date: 2007-12-11; Completion date: 2009-06-26
Enrollment: 318 participants; Allocation: RANDOMIZED; Intervention model: PARALLEL

Brief summary:
To evaluate the safety and efficacy of PF-04217329.

Detailed description:

Arms: arm 1: None arm 2: None arm 3: None arm 4: None arm 5: None arm 6: None arm 7: None arm 8: None arm 9: None arm 10: None arm 11: None arm 12: None arm 13: None arm 14: None
Interventions: intervention 1: PF-04217329 - Lowest Dose intervention 2: PF-04217329 - Low Dose intervention 3: PF-04217329 - Middle Dose intervention 4: PF-04217329 - High Middle Dose intervention 5: PF-04217329 - High Dose intervention 6: PF-4217329 - Highest Dose intervention 7: PF-04217329 - Vehicle intervention 8: Latanoprost Vehicle intervention 9: PF-04217329 - Low Dose intervention 10: Latanoprost Vehicle intervention 11: PF-04217329 - Middle Dose intervention 12: Latanoprost Vehicle intervention 13: PF-04217329 - High Dose intervention 14: Latanoprost 0.005% intervention 15: PF-04217329 - Low Dose intervention 16: Latanoprost 0.005% intervention 17: PF-04217329 - Middle Dose intervention 18: Latanoprost 0.005% intervention 19: PF-04217329 - High Dose intervention 20: Latanoprost 0.005% intervention 21: PF-04217329 - Vehicle
Intervention descriptions: intervention 1: 1 drop of lowest dose PF-04217329, once a day, per dosed eye for duration of study. intervention 2: 1 drop of low dose PF-04217329, once a day, per dosed eye for duration of study. intervention 3: 1 drop of middle dose PF-04217329, once a day, per dosed eye for duration of study. intervention 4: 1 drop of high middle dose PF-04217329, once a day, per dosed eye for duration of study. intervention 5: 1 drop of high dose PF-04217329, once a day, per dosed eye for duration of study. intervention 6: 1 drop of highest dose PF-04217329, once a day, per dosed eye for duration of study. intervention 7: 1 drop of PF-04217329 vehicle, once a day, per dosed eye for duration of study. intervention 8: 1 drop of latanoprost vehicle, once a day, per dosed eye for duration of study. intervention 9: Five minutes after latanoprost vehicle, 1 drop of low dose PF-04217329, once a day, per dosed eye for duration of study. intervention 10: 1 drop of latanoprost vehicle, once a day, per dosed eye for duration of study. intervention 11: Five minutes after latanoprost vehicle, 1 drop of middle dose PF-04217329, once a day, per dosed eye for duration of study. intervention 12: 1 drop of latanoprost vehicle, once a day, per dosed eye for duration of study. intervention 13: Five minutes after latanoprost vehicle, 1 drop of high dose PF-04217329, once a day, per dosed eye for duration of study. intervention 14: 1 drop of latanoprost 0.005%, once a day, per dosed eye for duration of study. intervention 15: Five minutes after latanoprost 0.005%, 1 drop of low dose PF-04217329, once a day, per dosed eye for duration of study. intervention 16: 1 drop of latanoprost 0.005%, once a day, per dosed eye for duration of study. intervention 17: Five minutes after latanoprost 0.005%, 1 drop middle dose PF-04217329, once a day, per dosed eye for duration of study. intervention 18: 1 drop of latanoprost 0.005%, once a day, per dosed eye for duration of study. intervention 19: Five minutes after latanoprost 0.005%, 1 drop high dose PF-04217329, once a day, per dosed eye for duration of study. intervention 20: 1 drop of latanoprost 0.005%, once a day, per dosed eye for duration of study. intervention 21: Five minutes after latanoprost 0.005%, 1 drop of PF-04217329 vehicle, once a day, per dosed eye for duration of study.

Protocol documents: