Commission Regulation (EU) 2025/2274 of 12 November 2025 amending Regulation (EU) 2024/1487 as regards the adoption of the work programme for the gradual review of safeners and synergists
Date: 2025-11-12
Institutions: Directorate-General for Health and Food Safety, European Commission
Subjects: disclosure of information, environmental protection, health risk, market approval, plant health control, plant health product, statistical method, testing








L_202502274EN.000101.fmx.xml












Official Journal of the European Union


EN
L series













2025/2274


13.11.2025







            COMMISSION REGULATION (EU) 2025/2274
of 12 November 2025
         
amending Regulation (EU) 2024/1487 as regards the adoption of the work programme for the gradual review of safeners and synergists
(Text with EEA relevance)


THE EUROPEAN COMMISSION,

Having regard to the Treaty on the Functioning of the European Union,


Having regard to Regulation (EC) No 1107/2009 of the European Parliament and of the Council of 21 October 2009 concerning the placing of plant protection products on the market and repealing Council Directives 79/117/EEC and 91/414/EEC (1), and in particular Article 26 thereof,

Whereas:







(1)


Commission Regulation (EU) 2024/1487 (2) lays down the data requirements for the approval of safeners and synergists and establishes a work programme for the gradual review of safeners and synergists that are already on the market. This work programme aims at allowing all safeners and synergists already on the market to be gradually reviewed and approved in accordance with Regulation (EC) No 1107/2009, within five years of its adoption.












(2)


In accordance with Article 3(1) of Regulation (EU) 2024/1487, the Commission published, by electronic means, a list of all substances or preparations known to be used as safeners or synergists in plant protection products authorised for placement on the market in at least one Member State at the date of 19 June 2024.












(3)


In accordance with Article 3(2) of Regulation (EU) 2024/1487, interested parties submitted notifications of further substances or preparations potentially used as safeners or synergists in plant protection products on 19 June 2024 to the Commission and, in accordance with Article 3(4) of that Regulation, Member States and the European Food Safety Authority (the ‘Authority’) provided comments to the Commission in regard to the notifications received.












(4)


In accordance with Article 3(5) of Regulation (EU) 2024/1487, the Commission updated the list referred to in Article 3(1), taking into account the notifications submitted by interested parties and the comments provided by Member States and the Authority. The updated list ensures that all safeners and synergists used in plant protection products as of 19 June 2024 are identified and considered for inclusion in the work programme.












(5)


In accordance with Article 4 of Regulation (EU) 2024/1487, interested parties requested the inclusion of the substances listed in the Annex to this Regulation in the work programme for gradual review.












(6)


The Commission assessed the notifications submitted by the interested parties and the comments provided by Member States and the Authority under Article 3 of Regulation (EU) 2024/1487 and the requests for inclusion submitted by the interested parties under Article 4 of that Regulation. That assessment has identified the safeners and synergists eligible for inclusion in the work programme.












(7)


Pursuant to Article 6(2) of Regulation (EU) 2024/1487, the Commission is to adopt the work programme by updating Annex I to that Regulation, specifying the safeners and synergists included in the work programme and designating for each of them a rapporteur Member State and a co-rapporteur Member State.












(8)


Regulation (EU) 2024/1487 should therefore be amended accordingly.












(9)


The measures provided for in this Regulation are in accordance with the opinion of the Standing Committee on Plants, Animals, Food and Feed,





HAS ADOPTED THIS REGULATION:



Article 1
The work programme for the gradual review of the safeners and synergists already used in plant protection products is hereby adopted.
Annex I to Regulation (EU) 2024/1487 is amended in accordance with the Annex to this Regulation.


Article 2
This Regulation shall enter into force on the twentieth day following that of its publication in the Official Journal of the European Union.




This Regulation shall be binding in its entirety and directly applicable in all Member States.
Done at Brussels, 12 November 2025.


For the Commission


The President

Ursula VON DER LEYEN
            





(1)  
            OJ L 309, 24.11.2009, p. 1, ELI: http://data.europa.eu/eli/reg/2009/1107/oj.

(2)  Commission Regulation (EU) 2024/1487 of 29 May 2024 defining data requirements for the approval of safeners and synergists and establishing a work programme for the gradual review of safeners and synergists on the market in accordance with Regulation (EC) No 1107/2009 of the European Parliament and of the Council (OJ L, 2024/1487, 30.5.2024, ELI: http://data.europa.eu/eli/reg/2024/1487/oj).




ANNEX
Annex I to Regulation (EU) 2024/1487 is replaced by the following:



‘ANNEX I
List of safeners and synergists included in the work programme for gradual review as referred to in Article 6(2)












Safener




Common name, ISO-name, and/or synonyms




Chemical name (IUPAC and CA nomenclature)




CAS number




EC number




Rapporteur Member State (RMS)




Co-rapporteur Member State (Co-RMS)





Cloquintocet mexyl


Cloquintocet-mexyl


heptan-2-yl 2-(5-chloroquinolin-8-yl)oxyacetate


99607-70-2


619-447-3


ES


PT




Cloquintocet


Cloquintocet


2-[(5-chloroquinolin-8-yl)oxy]acetic acid


88349-88-6


635-476-4 and 926-839-0


ES


PT




Cyprosulfamide


Cyprosulfamide


N-[4-(cyclopropylcarbamoyl)phenyl]sulfonyl-2-methoxybenzamide


221667-31-8


619-679-5


NL


BE




Isoxadifen-ethyl


Isoxadifen-ethyl


ethyl 5,5-diphenyl-4H-1,2-oxazole-3-carboxylate


163520-33-0


443-870-0


AT


SI




Mefenpyr-diethyl


Mefenpyr-diethyl


diethyl 1-(2,4-dichlorophenyl)-5-methyl-4H-pyrazole-3,5-dicarboxylate


135590-91-9


603-923-2


AT


DE




Metcamifen


Metcamifen


2-methoxy-N-{4-[(methylcarbamoyl)amino]benzenesulfonyl}benzamide


129531-12-0


884-589-7


IT


RO





Synergist




Common name, ISO-name, and/or synonyms




Chemical name (IUPAC and CA nomenclature)




CAS number




EC number




Rapporteur Member State (RMS)




Co-rapporteur Member State (Co-RMS)





Piperonyl butoxide


Piperonyl butoxide


5-[2-(2-butoxyethoxy)ethoxymethyl]-6-propyl-1,3-benzodioxole


51-03-6


200-076-7


EL


DE




Rape seed oil


Rape seed oil


Not available


8002-13-9


Not available


NL


FI




Edetic acid (EDTA)


Edetic acid (EDTA)


2,2',2",2"'-(Ethane-1,2-diyldinitrilo)tetraacetic acid


60-00-4


200-449-4


DK


PL




Disodium EDTA dihydrate


Disodium EDTA dihydrate


disodium dihydrogen 2,2',2",2"'-(ethane-1,2- diyldinitrilo)tetraacetate dihydrate


6381-92-6


205-358-3


DK


PL






            ’
         



ELI: http://data.europa.eu/eli/reg/2025/2274/oj
ISSN 1977-0677 (electronic edition)