Guidance on labelling and packaging in accordance with Regulation (EC) No 1272/2008.
Date: 2016-12-16
Institutions: European Chemicals Agency
Subjects: chemical industry, chemical product, classification, dangerous substance, environmental protection, labelling, packaging, public health, user guide

2 

Introductry Guidance on the CLP Regulation 
Draft (public) version 2.0 February 2015 

C L A S S I F I C A T I O N   &   L A B E L L I N G  

Guidance on labelling and packaging in 
accordance with Regulation (EC) No 1272/2008 

September 2016 
Version 2.0 

 
 
 
 
 
 
 
 
Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

2 

LEGAL NOTE: 

This document aims to assist users in complying with their obligations under the CLP 
Regulation. However, users are reminded that the text of the CLP is the only authentic legal 
reference and that the information in this document does not constitute legal advice. Usage 
of the information remains under the sole responsibility of the user. The European 
Chemicals Agency does not accept any liability with regard to the use that may be made of 
the information contained in this document. 

Version 

Changes 

1.0 (originally 
unnumbered) 

First edition  

2.0 

Full revision of the guidance addressing the content and structure. Main changes in 
the guidance document include the following: 

  Alignment with the 4th Adaptation to Technical Progress (ATP) to the CLP 

Regulation (Commission Regulation (EU) No 487/2013) bringing the CLP in 
line with the 4th revised edition of the UN Globally Harmonised System 
(GHS); 

  Addressing the provisions of the 5th ATP to the CLP Regulation (Commission 

Regulation (EU) No 944/2013) amending precautionary statement P210 to 
fully align it with the changes arising from the 5th Revision of the UN GHS; 

  Addition of new section 3.5.1 on child-resistant fastening (CRF) and tactile 

warnings of danger (TWD); 

  Addition of new section 3.5.2 including information on additional safety 

measures for liquid laundry detergents in soluble capsules adopted by the 
Commission through Regulation (EU) No 1297/2014; 

  Addition of new sections 4.2.1 and 4.2.2 clarifying the provisions of CLP 

Article 18(3) with regard to product identifiers for substances and mixtures; 

  Re-organisation of information in section 4.3 by inclusion of new sub-

sections 4.3.1, 4.3.2, 4.3.3; 

  Addition of new section 4.3.4 describing the issue of blank pictograms; 

  Re-organisation and clarification of information on supplemental labelling in 

section 4.8 by inclusion of new sub-sections 4.8.1 and 4.8.2; 

 

Inclusion of clarification on the issue of “readability” and “minimum letter 
size” in section 5.2; 

  Re-organisation and update of the text in section 5.3 to reflect the 
provisions of CLP Article 29 and points 1.5.1 and 1.5.2 of Annex I; 

 

Inclusion of information on general and specific requirements for fold-out 
labels in section 5.3.1.1; 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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Guidance on Labelling and Packaging 

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  Section 6: Update of the labels and the text in examples in line with the 

provisions of the 4th and 5th ATPs to CLP; 

  Deletion of Example 6.6 (Single language label of a plant protection product 

for supply & use in form of a fold-out booklet); 

 

Inclusion of new Example 6 (fold-out label for a mixture supplied to the 
general public); 

  Addition of sub-section 6.1 separating the examples of labels on packagings 

that are small or difficult to label;  

  Addition  of  a  new  section  6.1  describing  labelling  of  two-component 

products; 

  Clarification and extension of the text in section 7.2; 

  Section 7.3: Update of the precautionary statements in selection tables 

according to the provisions of the 4th and 5th ATPs to CLP;  

  Section 7.4: Update of the practical examples in line with the provisions of 

the 4th and 5th ATPs to CLP; 

  Deletion of the outdated references to past deadlines and to the DSD and 

DPD provisions thorough the whole document; 

  Alignment of the document with the latest ECHA corporate image 

requirements. 

Guidance on labelling and packaging in accordance with Regulation (EC) No 
1272/2008 

Reference: ECHA-16-G-05-EN 
Cat. Number: ED-02-16-376-EN-N 
ISBN: 978-92-9495-093-2 
DOI: 10.2823/318237 
Publ. date:   September 2016  
Language:   EN  

© European Chemicals Agency, 2016 

If you have questions or comments in relation to this document please send them 
(indicating the document reference, issue date, chapter and/or page of the document to 
which your comment refers) using the Guidance feedback form. The feedback form can be 
accessed via the ECHA Guidance website or directly via the following link: 
https://comments.echa.europa.eu/comments_cms/FeedbackGuidance.aspx  

European Chemicals Agency 

Mailing address: P.O. Box 400, FI-00121 Helsinki, Finland 
Visiting address: Annankatu 18, Helsinki, Finland 

 
 
 
 
 
 
 
 
 
 
 
 
 
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Table of Contents 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

PREAMBLE ............................................................................................................................. 1 

1. INTRODUCTION .............................................................................................................. 2 

1.1 Who should read this document?........................................................................................ 2 

1.2 What is in this document? ..................................................................................................... 2 

2. GENERAL OVERVIEW .................................................................................................... 3 

2.1 Legal background ...................................................................................................................... 3 

2.2 Scope of labelling and packaging under the CLP Regulation .................................. 4 

2.3 Timelines for classification, labelling, packaging and updating of CLP hazard 
labels ...................................................................................................................................................... 5 

3. REQUIREMENTS OF LABELLING AND PACKAGING IN ACCORDANCE WITH 
THE CLP REGULATION ....................................................................................................... 7 

3.1 General labelling rules ............................................................................................................. 7 

3.2 Elements of the CLP hazard label ....................................................................................... 7 

3.3 Location of information on the CLP hazard label.......................................................... 8 

3.4 Differences between CLP and DSD/DPD labelling rules ............................................ 9 

3.5 CLP rules on packaging of substances and mixtures ................................................ 11 
3.5.1 Child-resistant fastening and tactile warnings of danger ................................................ 12 
3.5.2 Liquid consumer laundry detergents in soluble packaging for single use................. 15 

4. RULES FOR THE APPLICATION OF THE CLP LABEL ELEMENTS .....................17 

4.1 Contact details of the supplier ........................................................................................... 17 

4.2 Product identifiers ................................................................................................................... 17 
4.2.1 Substances ......................................................................................................................................... 17 
4.2.2 Mixtures ............................................................................................................................................... 18 

4.3 Hazard pictograms .................................................................................................................. 20 
4.3.1 General information ........................................................................................................................ 20 
4.3.2 Shape, colour and dimensions .................................................................................................... 20 
4.3.3 Precedence rules .............................................................................................................................. 21 
4.3.4 Blank pictograms ............................................................................................................................. 22 

4.4 Signal words .............................................................................................................................. 23 

4.5 Hazard statements .................................................................................................................. 24 

4.6 Precautionary statements .................................................................................................... 25 

4.7 Codes for hazard and precautionary statements ....................................................... 26 

4.8 Supplemental labelling information ................................................................................. 26 
4.8.1 Obligatory supplemental labelling information ................................................................... 27 
4.8.2 Non-obligatory supplemental labelling information .......................................................... 33 

5. GUIDANCE ON PARTICULAR ASPECTS OF CLP HAZARD LABELLING ..........34 

 
 
 
 
 
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5.1 Further aspects to consider for the CLP hazard label ............................................... 34 

5.2 Size of the label and of the label elements ................................................................... 34 

5.3 Exemptions from the labelling and packaging requirements ................................ 37 
5.3.1 Use of fold-out labels, tie-on tags and outer packaging .................................................. 37 
5.3.2 Omission of certain label elements........................................................................................... 40 

5.4 Interaction between the CLP and the transport labelling rules ........................... 44 

5.4.1 Specific rules for labelling of outer packaging, inner packaging and single 
packaging ....................................................................................................................................................... 44 

6. EXAMPLE LABELS ..........................................................................................................46 

Example 1: Single language label of a substance (not for the general public) ..... 46 

Example 2: Multi-language label of a substance containing non-obligatory 
supplemental information (not for the general public) .................................................. 47 

Example 3: Single language label of a mixture containing both obligatory and 
non-obligatory supplemental information (supplied to the general public) .......... 49 

Example 4: Single language label of a substance containing supplemental hazard 
statements (not for the general public) ................................................................................ 51 

Example 5: Multi-language label of a mixture containing both obligatory and 
non-obligatory supplemental information (supplied to the general public) .......... 51 

Example 6: Fold-out label of a mixture (supplied to the general public) ................ 54 

6.1 Packaging that is small or difficult to label .................................................................. 56 
Example 7: n-Hexane in a 8 ml bottle (not for the general public) ......................................... 56 
Example 8: Hazardous solid substance in a 100 ml bottle (not intended for the general 
public) ............................................................................................................................................................. 59 
Example 9: Supply and transport label for a single package (not intended for the 
general public) ............................................................................................................................................. 61 
Example 10: Labelling of a mixture that is transported on land in outer and inner 
packaging (not intended for the general public) ............................................................................ 63 
Example 11: Labelling of a mixture that is transported on land in single packaging (not 
intended for the general public) ........................................................................................................... 64 

6.2 Specific case: labelling of two-component products ................................................ 66 

7. GUIDANCE ON THE SELECTION OF PRECAUTIONARY STATEMENTS FOR 
THE CLP HAZARD LABEL ..................................................................................................67 

7.1 Introduction ............................................................................................................................... 67 

7.2 Methodology .............................................................................................................................. 68 

7.3 Selection tables ........................................................................................................................ 71 
7.3.1 General precautionary statements ........................................................................................... 72 
7.3.2 Specific precautionary statements for physical hazards .................................................. 73 
7.3.3 Specific precautionary statements for health hazards.................................................... 124 
7.3.4 Specific precautionary statements for environmental hazards ................................... 169 
7.3.5 Additional hazards......................................................................................................................... 172 

7.4. Examples for the selection of precautionary statements for the label .......... 173 
Example A. Substance X assigned a physical and various health hazard classifications
 ......................................................................................................................................................................... 173 

 
 
 
 
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Example B. Sodium peroxide Na2O2, (EC: 215-209-4) assigned a severe physical and 
health hazard classification .................................................................................................................. 175 
Example C. Dimethylzinc (EC: 208-884-1) assigned physical, health and environmental 
classifications ............................................................................................................................................. 177 
Example D. Mixture ABC for use by the general public .............................................................. 179 

APPENDIX: GLOSSARY OF SELECTED TERMS USED IN THIS GUIDANCE ..... 182 

Table of Figures 

Figure 1: Timelines for classification and labelling in accordance with CLP and DSD/DPD. ... 6 

Figure 2: Comparison of certain important label elements under CLP and DSD ................... 10 

Figure 3. Blackened out empty diamonds............................................................................ 23 

Figure 4: Readability ........................................................................................................... 35 

Figure  5:  Decision  flowchart  for  the  application  of  CLP  and  transport  labelling  for  single 
packaging (left) and combination packaging (right) ........................................................... 45 

Table of Tables 

Table 1: CLP labelling requirements versus discretion of the supplier .................................. 8 

Table  2:  The  hazard  classifications  that  trigger  the  CLP  provisions  for  child-resistant 
fastenings and/or tactile warnings ..................................................................................... 14 

Table  3:  Substances  that  directly  trigger  the  CLP  provisions  for  child-resistant  fastenings 
and/or  tactile  warnings  when  they  are  contained  in  other  substances  or  in  mixtures  at  or 
above the denoted concentration ........................................................................................ 15 

Table 4:  Code ranges of hazard and precautionary statements under CLP ......................... 26 

Table  5:  Obligatory  supplemental  labelling  information  pursuant  to  CLP  Articles  25  and  32
 ........................................................................................................................................... 29 

Table 6: Minimum dimensions of labels and pictograms under CLP ..................................... 35 

Table 7: Labelling exemptions for packages of a capacity of 125 ml or less ........................ 41 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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Preamble 

This document describes specific provisions for labelling and packaging of chemical 
substances  and  mixtures  under  Titles  III  and  IV  of  the  Regulation  (EC)  No 
1272/20081  (CLP  Regulation  or  CLP).  The  aim  of  this  document  is  to  assist 
manufacturers,  importers,  downstream  users  and  distributors  of  substances  and 
mixtures in the effective application of the CLP Regulation. 

This guidance includes relevant amendments from the 2nd, 4th and 5th Adaptation to 
Technical  Progress  (ATP)  to  the  CLP  Regulation,  as  well  as  the  changes  brought 
about  by  the  ATP  to  CLP  related  to  labelling  and  packaging  of  liquid  laundry 
detergents in a soluble packaging for single use (Regulation (EU) No 1297/2014).  

All  current  ECHA  guidance  documents  can  be  obtained  via  the  website  of  ECHA 
(http://echa.europa.eu/support/guidance ). 

1 Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 
on classification, labelling and packaging of substances and mixtures, amending and repealing 
Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006;  OJ L 353 
31.12.2008, p. 1 (http://eur-lex.europa.eu/legal-content/en/TXT/?uri=CELEX%3A02008R1272-
20150601)  

 
 
 
 
                                                 
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1. Introduction  

1.1 Who should read this document? 

This document is relevant for suppliers of chemical substances and mixtures, namely for: 

  manufacturers and importers of substances; 

 

importers of mixtures; 

  downstream users of substances and mixtures, including formulators; 

  distributors of substances and mixtures, including retailers. 

All suppliers must ensure that their substances and mixtures are labelled and packaged in 
accordance with the provisions of the CLP Regulation (or CLP) before they are placed on the 
EU market. 

1.2 What is in this document? 

This document provides guidance on the labelling and packaging requirements set out in the 
CLP Regulation. The guidance opens in section 2 with a general overview, including legal 
background and scope of the CLP Regulation. That section also includes information about 
timelines for classification, labelling, packaging and updating of CLP labels. The guidance 
continues in section 3 and 4 with an explanation of requirements for labelling and packaging 
and rules for the application of the CLP label elements. Section 5 provides the guidance on 
particular aspects of CLP hazard labelling (e.g. exemption from certain labelling and 
packaging requirements, interaction between CLP and transport labelling rules, labelling 
requirements for specific cases of unique packaging). Finally, sections 6 and 7 of the 
guidance provide practical examples illustrating different situations that may be 
encountered when designing labels. 

In particular, this guidance aims to clarify: 

  what aspects to consider when estimating the label size needed; 

  what types of supplemental information are possible, and where to place this 

information on the label (sub-section 4.8 of this guidance); 

 

 

 

the conditions for small packaging exemptions; 

the interaction between CLP and the transport labelling rules; 

the technical requirements for liquid laundry detergents in a soluble packaging for 
single use; 

  how to select the most appropriate set of precautionary statements for the label; 

  how to structure the information on the label for appropriate readability. 

For specific information on application of the CLP criteria for physical, health and 
environmental hazards the reader is advised to consult the Guidance on the application of 
the CLP criteria. For a general overview of basic features and procedures laid down in the 
CLP Regulation it might be useful to consult the Introductory Guidance on the CLP 
Regulation. Both the above-mentioned guidance documents are available at: 
http://echa.europa.eu/web/guest/guidance-documents/guidance-on-clp.

 
 
 
 
 
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2. General overview 

2.1 Legal background 

CLP is the EU Regulation on classification, labelling and packaging of substances 
and mixtures. It is based on the United Nations Globally Harmonized System of 
Classification and Labelling of chemicals (UN GHS). CLP entered into force on 20 
January 2009 in the European Union and is now legally binding also in the 
countries of the European Economic Area (EEA) (Norway, Iceland and 
Liechtenstein)2. CLP has fully replaced the provisions of the Dangerous 
Substances Directive 67/548/EEC (DSD) and the Dangerous Preparations 
Directive 1999/45/EC (DPD) as of 1 June 2015 (see sub-section 2.3 of this 
guidance for the applicability of the transitional period). The CLP Regulation is 
directly applicable to suppliers in the EU who manufacture, import, use or 
distribute chemical substances and mixtures.  

CLP includes several new aspects to the labelling and packaging of substances 
and mixtures. This guidance explains the labelling and packaging rules of CLP and 
illustrates with some examples how labels could be laid out.  

In general, the CLP label must display the label elements which are taken over 
from UN GHS, i.e. the new pictograms, signal word, hazard and precautionary 
statements, to reflect the assigned classification of a substance or mixture. At the 
same time, CLP retains some of the labelling concepts of DSD and DPD, such as 
the small packaging exemptions. In order to accommodate certain hazard 
information not yet covered by the UN GHS, as well as further label elements 
which are required by other EU legislation, CLP introduces the concept of 
“supplemental information” for the label. 

A substance or mixture classified as hazardous and contained in packaging must 
bear a hazard label in accordance with the rules in Title III of CLP (Hazard 
communication in the form of labelling).  

Another key tool used for hazard communication is the safety data sheet (SDS). 
The required SDS format and content are defined in Article 31 and Annex II3 to 
Regulation (EC) No 1907/2006 (REACH). These have been adapted to align them 
with the UN GHS, as well as to be fully in line with the CLP Regulation. 

For further information on the compilation of the SDS, please consult the 
Guidance on the compilation of safety data sheets 
(http://echa.europa.eu/guidance-documents/guidance-on-reach). 

2 The CLP Regulation was incorporated in the EEA Agreement by Decision of the EEA Joint 
Committee  No  106/2012  of  15  June  2012  amending  Annex  II  (Technical  regulations, 
standards, testing and certification) to the EEA Agreement (OJ L 309, 8.11.2012, p. 6–6).   

3 Commission Regulations No 453/2010 and No 2015/830 have amended the REACH 
Regulation by replacing Annex II to REACH with the annexes to these regulations, to align 
the requirements for safety data sheets with the rules for safety data sheets of the UN 
GHS, see: http://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html.  

 
 
 
 
 
                                                 
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2.2 Scope of labelling and packaging under the CLP 
Regulation 

In general, substances and mixtures that are placed on the market are supplied 
in packaging with the necessary labelling information. A substance or mixture has 
to be labelled according to the CLP rules where 

 

 

the substance or mixture is classified as hazardous; 

the mixture, even if not classified as hazardous, is addressed in Article 
25(6) of CLP. In this case the supplemental label elements as set out in 
part 2 of Annex II must be indicated together with the product identifier, 
name and telephone number of the supplier. 

In addition, an explosive article (i.e. an article containing one or more explosive 
substances or mixtures) which meets the criteria described in section 2.1 of 
Annex I to CLP must be labelled according to the CLP rules.  

Substances and mixtures within the scope of Regulation (EC) No 1107/20094 
(Plant Protection Products Regulation or PPPR) or Regulation (EU) No 528/2012 
(Biocidal Products Regulation or BPR) have to carry CLP labelling elements as 
appropriate; substances and mixtures within the scope of the PPPR also need to 
display the supplemental statement EUH401 (To avoid risks to human health and 
the environment, comply with the instructions for use), see CLP Article 25 (2). On 
the other hand, the labelling provisions of these acts remain fully applicable to 
any product within their scope, see Recital 47 of the CLP Regulation. For example, 
there are separate provisions for updating labels for such substances and 
mixtures in these acts, and their suppliers must apply these provisions instead of 
the CLP rules, see also CLP Article 30 (3). Another deviation from CLP is that 
different rules apply as to which information may be presented in the form of a 
leaflet as an alternative way to accommodate the required labelling information 
(sub-section 5.3.1.1 of this guidance). 

The CLP Regulation also includes exemptions from labelling and packaging 
requirements, for example for packaging that is so small, or in such a shape that 
it is impossible to meet the general rules for the application of labels (sub-section 
5.3.1 of this guidance). In addition, CLP allows suppliers to omit certain label 
elements (sub-section 5.3.2 of this guidance). 

Certain substances and mixtures may also be supplied to the general public 
without packaging, in which case a copy of the label elements is required to 
accompany the substance or mixture, for example on an invoice. Currently, this 
only applies to ready mixed cement and concrete in the wet state (sub-section 
5.3.2.4 of this guidance).  

Finally, CLP defines derogations from the CLP labelling requirements for special 
cases and the conditions under which these derogations apply, for example 
transportable gas cylinders. In relation to the aforementioned cases, please 
consult Article 23 and section 1.3 of Annex I to CLP, as further guidance on these 
is not provided in this document. 

4 Regulation (EC) No 1107/2009 of the European Parliament and of the Council of 21 
October 2009 concerning the placing of plant protection products on the market repeals 
Council Directives 79/117/EEC and 91/414/EEC with effect from 14 June 2011. 
However, Article 80 of Regulation (EC) No 1107/2009 specifies that Directive 
91/414/EEC must continue to apply with respect to active substances included in Annex 
I to that Directive for certain transitional periods.  

 
 
 
 
                                                 
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2.3 Timelines for classification, labelling, packaging and 
updating of CLP hazard labels 

The CLP Regulation was introduced gradually before its full application as of 1 
June 2015. During this transitional period some of the rules of CLP and the 
previous legislation (DSD and DPD) were applicable in parallel to give companies 
time to migrate to the CLP rules. However, companies were allowed to apply CLP 
in full, on a voluntary basis, from its entry into force.  

For substances, it has been obligatory to classify, label and package according to 
the CLP Regulation since 1 December 2010. The same obligations have applied 
for mixtures since 1 June 2015.  

Therefore, from 1 June 2015 both substances and mixtures must be 
classified, labelled and packaged according to CLP only. This classification 
must be provided in the SDS for substances and mixtures. There is no longer a 
requirement to provide either DSD classifications of substances themselves or of 
component substances in mixtures or the DPD classifications for mixtures in the 
SDS. Only the corresponding information according to CLP need be provided (see 
also the Guidance on the compilation of safety data sheets).  

Limited derogation for re-labelling and re-packaging 

In the situation where a mixture was already classified, labelled and packaged in 
accordance with the DPD rules and placed on the market before 1 June 2015, the 
manufacturer, importer, downstream user or distributor may postpone its re-
labelling and re-packaging to comply with the CLP rules until 1 June 2017 at the 
latest. This means that the mixture can be sold further in the supply chain with 
the DPD label until 1 June 2017 (see Article 61 (4) of CLP). The mixtures 
prepared before 1 June 2015 and stored in a formulator’s warehouse after 1 June 
2015 can also benefit from this arrangement provided they are already labelled 
and packaged according to the DPD rules5. This concerns also mixtures that are 
either on the shelves of a warehouse or a shop or in the stocks of a manufacturer 
or importer6. There needs to be proof that the products were already packaged 
and labelled on 1 June 2015 for the transitional provision to apply. This could be 
done by providing evidence that the mixture had been manufactured ("physically 
existing"), had passed a manufacturer's quality control system (was "cleared for 
sale"), was labelled and was made available for a third party e.g. in the 
warehouse. This could also include e.g. an offer for sale through an 
advertisement on a website.  

It should be noted that when a mixture is re-filled into another package on its 
way through the supply chain and the respective supplier (re-filler) changes the 
composition of the mixture in the course of his industrial and professional activity, 
he must classify the mixture according to the CLP requirements and no longer use 
the DPD labelling.  

5 The derogation regarding safety data sheets is explained in the Guidance on the 
compilation of safety data sheets available at http://echa.europa.eu/guidance-
documents/guidance-on-reach  

6 Please note that imports are exempted from CLP while they fall within the scope of Article 
1(2)(b). See also CLP FAQ ID=250 at http://echa.europa.eu/support/qas-support/qas. 

 
 
 
 
 
                                                 
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In the case of e.g. re-filling or re-labelling without change of the composition or 
change of label language, the re-filler or re-labeller may use the classification 
from their supplier and use the same label (in practice there will be physical re-
labelling but with the same hazard label or labelling information as the 
formulator's). 

An overview of the relevant timelines for classification and labelling is provided in 
Figure 1 below. 

Legislation 

Directive 
67/548/EEC 

(DSD) 

Regulation  
EC No 1272/2008 

(CLP) 

Directive 
1999/45/EC 

(DPD) 

Regulation  
EC No 1272/2008 

(CLP) 

s
e
c
n
a
t
s
b
u
S

s
e
r
u
t
x
i
M

From 
1 June 2015 

No longer applicable (i.e. not allowed) 

Classification, packaging and labelling required 

Not applicable (with the exception of the 2017 
derogation) 

Classification required 

Labelling and packaging required unless the 
2017 derogation applies 

Figure 1: Timelines for classification and labelling in accordance with CLP 
and DSD/DPD. 

Following any changes to the classification and labelling where the revised 
classification is more severe or where new supplemental label elements are 
required, CLP Article 30 requires a supplier to update this information on the label 
without undue delay, i.e. as soon as reasonably practicable.  

Where labelling changes other than those described above are required (e.g. 
where the revised classification will be less severe or the contact details of the 
supplier have changed) the supplier has 18 months to update the label.  

Where a new or updated harmonised classification arises from an Adaptation to 
Technical Progress (ATP) to the CLP Regulation, the ATP provides the date of 
applicability.  

Further label changes to be implemented within 18 months would also include the 
update of labelling information for certain mixtures for which special rules for 
supplemental labelling in accordance with Part 2 of Annex II to CLP apply. 

However, there are separate provisions for updating labels in the Biocidal 
Products Regulation (BPR) and the Plant Protection Products Regulation (PPPR) 
and suppliers of substances or mixtures within the scope of these acts must apply 
these provisions. 

 
 
 
 
 
 
 
 
 
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3. Requirements of labelling and packaging in 
accordance with the CLP Regulation 

3.1 General labelling rules 

General and specific rules regarding the content and application of a CLP label are 
set out in CLP Article 31.  

CLP requires that the labels are firmly affixed to one or more surfaces of the 
immediate container of the substance or mixture and that they must be readable 
horizontally when the package is set down normally. The label elements 
themselves, in particular the hazard pictograms, must stand out clearly from the 
background. Furthermore, all label elements must be of such size and spacing as 
to be easily read. They must be clearly and indelibly marked. A physical label is 
not required when the label elements are shown clearly on the packaging itself. 

3.2 Elements of the CLP hazard label 

According to CLP Article 17, a substance and mixture classified as hazardous must 
bear a label including the following elements: 

  Name, address and telephone number of the supplier(s); 

  The nominal quantity of the substance or mixture in the package where 
this is being made available to the general public, unless this quantity is 
specified elsewhere on the package; 

  Product identifiers; 

  Hazard pictograms, where applicable; 

  The relevant signal word, where applicable; 

  Hazard statements, where applicable;  

  Appropriate precautionary statements where applicable; 

  A section for supplemental information, where applicable. 

It should be noted that for particular label elements precedence rules apply. 
These rules are further explained in the sections below. 

  CLP requires the label to be written in the official language or languages of 

the Member States where the substance or mixture is placed on the 
market, unless the Member State concerned provides otherwise7. 
Suppliers may accomplish this either by producing multi-language labels 
covering the official languages of several of the countries where the 
substance or mixture is supplied, or by producing separate labels for each 
country, each with the appropriate language or languages.  

Suppliers may use more languages than those required on their labels if they 
wish, provided that the same details appear in all languages. However, this 
should not impact the legibility of the obligatory labelling information nor can it 
trigger exemptions from the labelling requirements, (sub-section 5.3.1 of this 
guidance). 

7 Please consult the table “Languages required for labels and safety data sheets” which is 
available on the ECHA website web at: http://echa.europa.eu/regulations/clp/labelling. 

 
 
 
 
                                                 
 
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3.3 Location of information on the CLP hazard label 

CLP Article 32 provides some limited rules that define the location of information 
on the label. However, further details as to how label elements are arranged are 
left to the discretion of the person responsible for compiling the label. As a 
general rule, the information should be structured in a way that is easy to read 
and understand. Examples are outlined in Table 1 below: 

Table 1: CLP labelling requirements versus discretion of the supplier 

CLP requirement (Article 32) 

Example of decision left to the 
discretion of the supplier 

The hazard pictograms, signal word, hazard 
statements  and  precautionary  statements 
must be kept together on the label. 

The  supplier 
arrangement of the pictograms. 

free 

is 

to  choose 

the 

Hazard  statements  must  be  grouped 
together on the label.  

The  supplier  may  choose  the  order  of  the 
hazard statements. 

Precautionary  statements  must  be  grouped 
together on the label.  

In case more than one language is used on 
the  label,  the  hazard  and  precautionary 
statements  of  the  same  language  must  be 
grouped together on the label. 

The  supplier  may  choose  whether  these 
groups  are  to  be  presented  on  the  left,  on 
the right or elsewhere on the label. 

The  supplier  may  choose  the  order  of  the 
precautionary 
should 
ensure  that  they  are  grouped  with  the 
hazard statements. 

statements,  but 

The  supplier  may  choose  whether  these 
groups  are  to  be  presented  on  the  left,  on 
the right or elsewhere on the label. 

Where the supplier needs to use alternative 
means  to  meet  the  requirements  of  CLP 
Article  31  in  relation  to  the  language(s) 
required  in  a  particular  Member  State,  he 
may  choose  whether  to  accomplish  this 
using  fold-out  labels,  tie-on  tags  or  on  an 
outer packaging, in accordance with section 
1.5.1 of Annex I 

Any supplemental information as referred to 
in  CLP  Article  25  must  be  included  in  the 
section 
labelling  and 
placed alongside the label elements referred 
to in CLP Article 17(1)(a)–(g). 

for  supplemental 

The  supplier  may  choose  how  to  visibly 
separate  this  section  from  the  section 
containing  the label  elements  referred to in 
CLP  Article  17(1)(a)-(g).  He  may  also 
decide  to  place  this  information  in  more 
than one location on the label. 

The label elements must be easily readable 
(Article 31(3)). 

It  is  recommended  to  keep  full  sentences 
together  and  in  one  line,  if  possible.  The 
font size and spacing must be large enough 
and  in  relation  to  the  dimensions  of  the 
label. 

 
 
 
 
 
 
 
 
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3.4 Differences between CLP and DSD/DPD labelling rules 

There is more required information on the CLP label compared to the DSD/DPD 
regime, and this requires more space on the label.  

One reason for this is that additional pictograms are required under CLP, 
compared to DSD/DPD, also some H- and P- statements are longer. Similarly, the 
new additional statements that apply under certain conditions: 'x % of the 
mixture consists of component(s) of unknown acute toxicity' and/or 'Contains x % 
of components with unknown hazards to the aquatic environment' consume 
additional space.  

Where mixtures have to be classified on the basis of the calculation methods, 
lower generic concentration limits trigger additional classification and labelling 
compared to DSD/DPD, which means that further hazard and precautionary 
statements must be put on the label.  

In contrast to DSD/DPD, combined hazard statements that would condense the 
message and save label space are limited in CLP to Acute Toxicity only (see sub-
section 4.5 of this guidance).   

CLP allows the omission of certain H-statements according to the principles of 
precedence given in Annex III, Part 1 (hazard statements).  

CLP also includes more precautionary statements compared to the number of 
safety phrases used under DSD/DPD.  

On the other hand, less prescriptive selection rules under CLP compared to DSD 
make it more difficult to stay within the maximum number of six precautionary 
statements on the label as intended by CLP (sub-section 4.6 and section 7 of this 
guidance).  

For illustration purposes, Figure 2 on the next page shows a comparison of 
certain important label elements8 under CLP and DSD: 

8  Figure  2  is  not  intended  to  be  a  label  that  complies  with  the  provisions  of  the  CLP 
Regulation, but is meant to present a rough overview of applicable label elements only. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
                                                 
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Comparison of certain important label elements 

CLP 

DSD 

     Hazard pictograms 

             Danger symbols  

     Signal word 

     Danger 

Indications of danger 

Toxic 

Dangerous for the  

                                                                          environment 

     Hazard statements 

Risk phrases 

     Toxic if swallowed or if inhaled                 

Toxic by inhalation and if 
swallowed 

     Causes severe skin burns and eye damage 

Causes burns 

     May cause an allergic skin reaction 

     May cause allergy or asthma symptoms  
     or breathing difficulties if inhaled 

May cause sensitisation by 
inhalation and by skin contact 

     Very toxic to aquatic life  

Very toxic to aquatic organisms 

  Selection from ca. 30 precautionary            S: (1/2-)26-36/37/39-45-61 
  statements9  

Figure 2: Comparison of certain important label elements under CLP and 
DSD  

9 Not more than six P-statements should appear on the label unless necessary (CLP Article 
28 (3)).  

      
 
 
 
 
 
 
   
 
 
 
                     
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
 
 
 
                                                 
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The example in Figure 2 shows that under CLP optimum use of the available 
space on the label may be a greater challenge than was the case under the 
DSD/DPD labelling regime.  

3.5 CLP rules on packaging of substances and mixtures 

Before continuing to describe in more detail the CLP requirements for packaging 
the reader should be introduced to the three CLP definitions: 

Article 2 (35): ‘package’ means the complete product of the packing operation, 
consisting of the packaging and its contents; 

Article 2 (36): ‘packaging’ means one or more receptacles and any other 
components or materials necessary for the receptacles to perform their 
containment and other safety functions; 

Article 2 (37): ‘intermediate packaging’ means packaging placed between 
inner packaging, or articles, and outer packaging; 

CLP Article 35 includes the requirements for packaging containing hazardous 
substances or mixtures. These provisions are to ensure that: 

 

 

 

the packaging is designed, constructed and fastened so that the contents 
cannot escape;  

the materials of the packaging and fastening are not damaged by the 
contents and are not liable to form hazardous compounds with the 
contents;     

the packaging and fastenings are strong and solid throughout to ensure 
that they will not loosen; 

  packaging fitted with replaceable fastening devices is properly designed to 

allow repeated refastening without the contents escaping; 

 

 

the packaging does not attract or arouse the curiosity of children or 
mislead the consumer when supplied to the general public; 

the packaging does not have a similar presentation or a design used for 
foodstuff or animal feed stuff or medicinal or cosmetic products which 
would mislead the consumers. 

Packaging that meets the requirements of the transport legislation is deemed to 
comply with the requirements set out in the bullet points above. (Note however 
that fulfilling the conditions in the above bullet points alone is usually not enough 
to comply with the requirements of the transport legislation).  

For substances and mixtures to be supplied to the general public, CLP sets out 
rules for: 

 
 
 
 
 
 
 
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12 

 

 

 

the use of child-resistant fastening (also referred to as child-resistant 
closure), see sub-section 3.5.1 of this guidance;  

the use of tactile warnings of danger (TWD), see sub-section 3.5.1 of this 
guidance; 

liquid consumer laundry detergents in soluble packaging for single use, 
(sub-section 3.5.2 of this guidance). 

The first two provisions are triggered by either a specific hazard class/category or 
by  the  concentration  of  specific  substances  contained  in  other  substances  or  in 
mixtures, see Table 2 and Table 3 of this guidance document.  

3.5.1 Child-resistant fastening and tactile warnings of danger  

The provisions described in this sub-section apply only for product packaging 
intended for the general public, for example: products on sale/offer at a retailer’s 
or an outlet where the general public have open access to them, products sold to 
the general public through a website.  

The requirements for child-resistant fastening and tactical warnings of danger do 
not apply for product packaging which is for professional users only. 

Child-resistant fastening (CRF) 

A child-resistant package10 is a package consisting of a container and appropriate 
closure which is difficult to open (or gain access to the contents) for young 
children under the age of fifty-two months, but which is not difficult for adults to 
use properly11. 

Annex II to CLP refers to two types of child-resistant fastening for packages: 

  non-reclosable package - a package which, when all or part of the 
contents have been removed, cannot be properly closed again, for 
example a blister pack or air freshener refills; 

 

reclosable package - a package (for example a one litre bottle or a five 
litre container) which after it has been initially opened, can be reclosed 
and re-used numerous times without loss of security. 

For fastening of the abovementioned packages, Annex II to CLP requires 
conformity with the following standards, as amended: 

  EN ISO 8317 (reclosable packages) and  

  CEN EN 862 (non-reclosable packages).   

Conformity with these standards may only be certified by laboratories which 
conform to EN ISO/IEC 17025, as amended. The EN ISO/IEC 17025 standard 
relates to the competence of testing laboratories and the requirements which 

10 Please note that the terminology differs between the CLP legal text and the EN standard. 
CLP refers to packaging fitted with child resistant fastening, whereas EN ISO 8317 refers 
to child resistant packages. 

11 According to EN ISO 8317.  

 
 
 
 
 
 
 
 
                                                 
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they are required to meet to demonstrate that they are technically competent and 
can generate technically valid results.  

A packaging of whatever capacity supplied to the general public must be fitted 
with a CRF for substances or mixtures: 

–  classified for acute toxicity 1-3 – oral (H300 and H301), dermal (H310 and 
H311) and inhalation (H330 and H331), STOT-SE 1 (H370), STOT-RE 1 
(H372), skin corrosion cat. 1, subcategories: 1A, 1B, 1C (H314), or 

–  classified as presenting an aspiration hazard (H304) with the exception of 
substances and mixtures that are placed on the market in the form of 
aerosols or in a container fitted with a sealed spray attachment, or 

–  containing methanol at a concentration greater or equal to 3% or 

dichloromethane at a concentrations greater or equal to 1% (see also 
Table 3 of this guidance document). 

Tactile warning of danger (TWD) 

Packages provided with a tactile warning of danger enable blind or visually 
impaired people to ascertain if the packages contain a hazardous substance or 
mixture. A TWD must be placed on the packaging, so that it can be felt before 
accessing the contents. The warning must be located in such a way that any other 
embossed patterns do not cause confusion. The exact location of the TWD must 
be according to EN ISO standard 11683.  

The TWD must also remain tactile during the expected period of use of the 
package under normal handling conditions. The TWD is not required on outer 
packaging such as for example a cardboard box protecting a glass bottle12. 

Annex II to CLP requires the TWD to conform to standard EN ISO 11683, as 
amended. The required standard TWD symbol (the “normal” symbol under the 
ISO standard) is an equilateral triangle. In exceptional cases (if the application of 
the normal symbol is not physically possible) the three dots symbol may be used. 
If it is not physically possible to even use the three dots symbol, the three mm 
symbol may be used13.  

A packaging of whatever capacity supplied to the general public must be fitted 
with TWD for substances or mixtures classified for: 

– 

acute toxicity 1-4 – oral  (H300, H301 and H302), dermal (H310, H311 

and H312) and inhalation (H330, H331 and H332), 

–  skin corrosion cat. 1, subcategories: 1A, 1B and 1C (H314), 

–  germ cell mutagenicity 2 (H341), 

–  carcinogenicity 2 (H351), 

– 

reproductive toxicity 2 (H361); 

12 According to EN ISO 11683. 

13 The arrangement and layout of the triangle, three dots as well as the three mm symbol 
are specified in EN ISO 11683. 

 
 
 
 
 
 
 
 
 
 
 
                                                 
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14 

– 

respiratory sensitisation 1, 1A and 1B (H334),  

–  STOT 1 or 2 (H370, H371, H372 and H373), 

–  aspiration hazard 1 (H304), 

– 

– 

– 

flammable gases 1 and 2 (H220 and H221),  

flammable liquids 1 and 2 (H224 and H225) or  

flammable solids 1 and 2 (H228). 

According to CLP Annex II, section 3.2.1.2 a TWD is not required for 
transportable gas receptacles. A TWD is also not required for aerosols and 
containers fitted with a sealed spray attachment containing substances or 
mixtures classified as presenting an aspiration hazard, unless they are classified 
for one or more of the other hazards mentioned above.  

Table 2 provides an overview of the hazard classifications triggering the CLP 
provisions for CRF and/or TWD. See also Table 3 which lists substances that can 
trigger the CLP provisions for CRF and/or TWD if they are present in other 
substances or in mixtures at a certain concentration. 

Table 2: The hazard classifications that trigger the CLP provisions for 
child-resistant fastenings and/or tactile warnings 

Hazard Class, Category 

Child-
resistant 
Fastenings 

Tactile 
Warnings 

Acute toxicity 1 to 3 

Acute toxicity 4 

STOT SE 1 

STOT SE 2 

STOT RE 1 

STOT RE 2 

Skin corrosion (category 1, subcategories: 1A, 1B and 1C) 

Respiratory sensitisation 1, 1A and 1B  

Aspiration hazard 1 
Note that a CRF and TWD are not required if the substance or 
mixture is supplied in the form of an aerosol or in a container 
fitted with a sealed spray attachment  

Germ cell mutagenicity 2 

Carcinogenicity 2 

Reproductive toxicity 2 

Flammable gases (category 1 and 2)  

Flammable liquids 1 and 2  

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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Hazard Class, Category 

Child-
resistant 
Fastenings 

Tactile 
Warnings 

Flammable solids 1 and 2  

 

Table  3:  Substances  that  directly  trigger  the  CLP  provisions  for  child-
resistant  fastenings  and/or  tactile  warnings  when  they  are  contained  in 
other substances or in mixtures at or above the denoted concentration 

Identification of the substance 

Concentration limit 

Methanol                       

Dichloromethane 

 3% 

 1% 

Child-
resistant 
Fastenings 

Tactile 
Warnings  

 

 

* 

** 

* It should be noted that above a certain concentration, methanol mixtures also need a tactile 

warning because the mixtures would then have to be classified as flammable liquid, category 2, 
STOT 1 or 2. 

** In addition, mixtures containing dichloromethane at a concentration above 1% would be classified 

as carcinogenic, category 2 and thereby need a tactile warning. 

3.5.2 Liquid consumer laundry detergents in soluble packaging for 
single use 

Additional safety measures for liquid laundry detergents in soluble capsules have 
been introduced. They aim to ensure better protection of the general public, 
especially young children who can be tempted to put the capsules into their 
mouth.  

The additional safety requirements make the packaging less attractive and more 
difficult to open for children. In addition, the packaging is to display warnings to 
alert parents and child-care providers that such products have to be kept out of 
reach of children.  

Besides these specific rules, the supplier is  responsible, according to Article 
35(2), for taking all necessary steps to make sure that the design of the 
packaging is not attractive to children, e.g. that it cannot be mistaken for 
foodstuff or toys. 

A consumer laundry detergent is a detergent used for laundry, placed on the 
market for use by non-professionals, including public launderettes14. 

Article 35(2) and Part 3.3 of Annex II to CLP provide the following requirements 
on packaging and labelling of liquid laundry detergents in dosages for single use 
contained in a soluble packaging: 

14 Article 2(1a) of Regulation 648/2004 on detergents. 

 
 
 
 
 
 
 
 
 
 
                                                 
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Obligation to market liquid consumer laundry detergents in an outer 
packaging 

Liquid consumer laundry detergents contained in soluble packaging for single use 
(for example liquid capsules or liquitabs for use in washing machines) must be 
contained in an outer packaging. Placing on the market of liquid detergent 
capsules without an appropriate outer packaging system is considered as non-
compliant with Article 35(1) and Annex II, section 3.3.1 of CLP. 

Provisions on the outer packaging 

In order to reduce the attractiveness of liquid detergent capsules to children, the 
outer packaging must be opaque or obscure (for example non-see through 
container of a block colour(s)) to prevent visibility of the contents, i.e. the 
product or individual doses. 

The outer packaging must bear precautionary statement P102 (“Keep out of reach 
of children”) at a visible place and in a format that attracts attention. 

Furthermore, the outer packaging must be a self-standing container, which is 
easily re-closable, i.e. the pack closure must be easily re-closable in one single 
movement (for example with one finger pressure for a tub packaging). This 
measure aims to avoid the risk that the container will simply be left open if 
closing is too difficult. 

As the main cause of incidents seems to be the easy access to the detergent 
capsules, the outer packaging must be fitted with a closure that impedes the 
ability of young children to open the packaging. Such a closure should require 
coordinated action of both hands with certain strength that makes it difficult for 
young children to open it. It should be noted that this requirement does not 
correspond necessarily with closure requirement for CRF described in section 
3.5.1 of this guidance. 

In addition, the pack closure must be designed for repeated use to maintain its 
functionality under conditions of repeated opening and closing for the entire life 
span of the outer packaging. 

Provisions on the soluble (inner) packaging 

Additional technical requirements (mechanical resistance and water dissolution) 
were introduced to make the soluble packaging more resistant. 

In addition to the requirements for the outer packaging, the soluble packaging 
must contain an aversive (e.g. bittering or other repulsive) agent against oral 
exposure. The aversive agent must be added in a concentration which is safe and 
which causes oral repulsive behaviour within a maximum time of six seconds. 

The soluble film must also meet minimum mechanical and dissolution resistance 
criteria. It must retain the liquid content for at least 30 seconds when placed in 
water at 20°C. It must also resist mechanical compression of at least 300 N under 
standard test conditions. 

The labelling of soluble packaging containing less than or equal to 25 ml may 
benefit from a labelling exemption under the conditions specified in section 
1.5.2.2 of Annex I to CLP, (sub-section 5.3.2.2 of this guidance); the labelling 
requirements of CLP Article 17 apply to soluble packaging where the contents are 
more than 25 ml. 

 
 
 
 
 
 
 
 
 
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4. Rules for the application of the CLP label 
elements 

4.1 Contact details of the supplier 

According to CLP Article 17, the contact details of one or several suppliers must 
be included on the label. In principle, there can be more than one supplier of the 
same substance or mixture in the supply chain, e.g. in case a mixture has been 
supplied by the formulator to a distributor who would supply it to third parties as 
well. However, CLP Article 17 does not specify whether the contact details of both 
suppliers are needed in such cases. Nor does it specify whether the contact 
details of one particular supplier have precedence. 

Following from CLP Article 4(4), each supplier must ensure that a hazardous 
substance or mixture is labelled and packaged in accordance with Titles III and IV 
of the CLP Regulation before he places it on the market. On the way through the 
supply chain the labelling for the same substance or mixture may vary depending 
on the volume of the package or as a consequence of further layers of packaging, 
(sub-section 5.2, sub-section 5.3 and sub-section 5.4 of this guidance).  

Where a supplier changes the packaging so that the label elements set out in CLP 
Article 17 have to be displayed differently than on the label/packaging supplied to 
him, he takes the responsibility for re-packaging and re-labelling and should add 
his own name and contact information on the label. In this case he may also 
replace the contact information of his supplier with his own contact details.  

When he does not change the packaging such that changes to the labelling would 
become necessary, he does not need to add his contact details to the label nor 
replace the contact information of his supplier with his own contact details, but 
may do so if he wishes to. In case he changes the languages(s) displayed on a 
label, he should add his contact details to the contact details of the relevant 
supplier who issued the original label, as he is then responsible for the correct 
translation of the label content.  

4.2 Product identifiers   

This sub-section provides guidance on the requirements for the product identifiers 
for substances (Article 18(2)) and mixtures (Article 18(3)).  

As a general rule, the same product identifier(s) as selected for the label must be 
used in the SDS15 for a substance or mixture. Any product identifiers selected for 
the label must be written in the official language(s) of the Member State(s) where 
the substance or mixture is placed on the market, unless the Member State 
concerned provides otherwise, see CLP Article 17(2). 

4.2.1 Substances 

The product identifier for a substance must consist of at least the following:  

  a name and an identification number as given in Part 3 of Annex VI to CLP  

15 For further information on the compilation of the SDS, please consult the Guidance on 
the compilation of safety data sheets (http://echa.europa.eu/guidance-
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The name can be any of the names stated as International Chemical 
Identification in column 2 of the tables in Part 3 of Annex VI to CLP. The 
identification number is typically the Index number, the EC number or the 
CAS number. It is recommended to use the number that warrants an 
unambiguous identification of the substance; in some cases it may be 
warranted to use two numbers, e.g. the CAS and the EC number. When 
translating the name of an Annex VI substance into the required 
language(s), it may be useful to check whether an appropriate translation 
is already available in a public database, for example in ECHA’s 
Classification and Labelling Inventory (C&L Inventory), see 
http://echa.europa.eu/web/guest/information-on-chemicals/cl-inventory-
database ; or 

 

if the substance is not included in Part 3 of Annex VI to CLP, a name and 
an identification number as they appear in the Classification and Labelling 
(C&L) Inventory. 

The name is typically the IUPAC name16, the EC name or the CAS name. 
The identification number must be the EC or the CAS number or the Index 
number (originating from table 3.1 of Annex VI). It is recommended to use 
the number or numbers that warrant(s) an unambiguous identification of 
the substance. The choice of an identifier such as (where applicable) the 
EC number or CAS number is advisable to minimise the need for revision 
of the SDS; or 

if the substance is neither included in Part 3 of Annex VI to CLP nor in the 
C&L Inventory database, the CAS number and the IUPAC name, or the 
CAS number and another international chemical name, e.g. the name in 
INCI nomenclature17, where applicable; or 

if no CAS number is available and none of the above apply, the IUPAC 
name or another international chemical name, e.g. the name in INCI 
nomenclature where applicable. 

 

 

4.2.2 Mixtures 

The product identifiers for mixtures must include both: 

 

 

the trade name or the designation of the mixture; and 

the identity of all substances in the mixture that contribute to the 
classification of the mixture as regards acute toxicity, skin corrosion or 
serious eye damage, germ cell mutagenicity, carcinogenicity, reproductive 

16 Where the IUPAC name exceeds 100 characters, suppliers can use one of the other 
names (usual name, trade name or abbreviation) referred to in section 2.1.2 of Annex VI 
REACH provided that a C&L notification to ECHA, in accordance with CLP Article 40(1)(b), 
includes both the IUPAC name and the other name used. 

17 The International Nomenclature Cosmetic Ingredients (INCI) name is mandatory in the 
European Union (EU) according to Regulation (EC) No 1223/2009 for labelling the names 
of ingredients on cosmetic products. The INCI system was introduced in the European 
Community in 1996/97 and is well established for cosmetic products. It is also used in 
many non-EU countries. Since 2004, the INCI system is also mandatory in the EU for 
labelling of preservatives and allergenic perfume ingredients according to the Detergents 
Regulation (EC) No 648/2004. 

 
 
 
 
                                                 
 
 
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toxicity, respiratory or skin sensitisation, specific target organ toxicity 
(STOT), or aspiration hazard.   

The CLP Regulation does not specify the type of chemical names18 that should be 
used to identify the chemical substances in the mixture. It only mentions the 
approach used for identification of substances in the mixture that contribute to 
the classification of the mixture (see Article 18(3)(b) and the second paragraph of 
Article 18(3)). Nevertheless, when choosing a chemical name, it is recommended 
that the approach outlined in Article 18(2) is followed. On that basis, if a name of 
the substance is shorter than other names available to the user/consumer or 
better recognised by the user/consumer in the language of the Member State 
where the mixture is placed on the market, this name should be used. This is 
often the case for common or basic ingredients. Furthermore, if there is a 
translated name available in Annex VI or in the C&L Inventory, this name should 
be given preference. 

In cases where another international chemical name (for example an INCI name) 
is better known by the user/consumer, it is possible to deviate from the Article 
18(2) approach. It is preferable to use the name that is regarded as well-known. 
The name of the substance needs to unambiguously define its identity. Where an 
INCI name does not sufficiently define the substance identity compared e.g. to 
the requirements of Article 18(2) or the requirements for SDSs under the REACH 
Regulation, a clearer identification should be preferred. 

If the trade name or the designation of the mixture already includes the name(s) 
of the substance(s) contributing to the classification of the mixture as defined in 
paragraph 3(b) of Article 18, they do not need to be repeated. Moreover, if the 
supplemental information on the label already contains the chemical name of the 
substance, e.g. in the list of allergens and preservatives required by Regulation 
(EC) No 648/2004 on detergents, it is advisable to use the same name. This 
approach should apply to both consumer and professional products.  

The selected chemical names must identify the substances primarily responsible 
for the major health hazards which have caused the classification of the mixture 
and the assignment of the corresponding hazard statements. 

To reduce the number of substance (‘chemical’) names on the label, no more than 
four names should be provided on the label for a mixture, unless necessary due 
to the nature and severity of the hazards. This may be the case where a mixture 
contains more than four substances which are all present in significant 
concentrations so that they contribute to the classification of the mixture for one 
or several of the hazards mentioned under the Article 18(3)(b). Please refer also 
to CLP FAQ ID=1050 available at http://echa.europa.eu/support/qas-support/qas. 

The manufacturer, importer or downstream user of certain less hazardous 
substances contained in a mixture may conclude that disclosing substance 
identifiers that are required for the label or the SDS can put the confidential 
nature of his business or intellectual property rights at risk. In such cases he may 
submit a request to ECHA to be granted permission to use an alternative chemical 
name in accordance with CLP Article 24. The alternative name should be a more 
general name identifying the most important functional groups or an alternative 
designation. The conditions under which the use of an alternative name may be 
granted are given in part 1, section 1.4 of Annex I to CLP. 

18 The terms used for identification of the mixture and the substances in the mixture must 
be the same as those used in the safety data sheet.  

 
 
 
 
                                                 
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The above requests are subject to a fee, in accordance with Article 3 of 
Commission Regulation (EU) No 440/2010 (the Fee Regulation). Where the 
request is submitted by a micro, small or medium-sized enterprise (SME)19, ECHA 
will levy a reduced fee as set out in Article 24(2) and Annex I of the Fee 
Regulation.  

For more information on how to request the use of an alternative chemical name 
for a substance in a mixture, please follow the technical instructions set out in the 
manual on preparation of REACH and CLP dossiers: How to prepare a request for 
use of an alternative chemical name for a substance in a mixture 
(http://echa.europa.eu/manuals).  

It is also advised to visit the following section on the ECHA website: 
http://echa.europa.eu/support/dossier-submission-tools/reach-it/requesting-an-
alternative-chemical-name-in-mixtures.  

4.3 Hazard pictograms   

4.3.1 General information 

A hazard pictogram is a pictorial presentation to communicate information on the 
hazard concerned, see also the definition provided in Articles 2(3) and 31(2) of 
CLP.  

According to CLP Article 19, the classification of a substance or mixture 
determines the hazard pictograms that have to be displayed on a label. 
Information on the assignment of hazard pictograms to specific hazard classes 
and categories/differentiations can also be found in Annex V to CLP.  

Currently there are nine different pictograms. While normally only one pictogram 
is assigned to an individual hazard class or category, a few hazard differentiations 
have to carry two pictograms, namely substances and mixtures classified as self-
reactive Type B or as organic peroxide Type B, see also below. It should also be 
noted that some pictograms cover several hazard classes and categories. 

4.3.2 Shape, colour and dimensions 

The colour and presentation of a label must allow the hazard pictogram and its 
background to be clearly visible. Hazard pictograms must be in the shape of a 
square set at a point, i.e. they must appear as a diamond shape when the label is 
read horizontally, and must have a black symbol on a white background with a 
red frame (see section 1.2.1 of Annex I to CLP). The exact type of red, i.e. the 
Pantone colour number, is not defined, and labellers are free to use their 
discretion.  

Each hazard pictogram20 must cover at least one fifteenth of the minimum surface 
area of the label dedicated to the information required by CLP Article 17, but the 
minimum area of the pictogram must not be less than 1 cm2. The minimum 
dimensions of labels and pictograms are given in Table 1.3 of Annex I to CLP.  

19 SME is defined in Commission Recommendation 2003/361/EC. 

20 The size of the pictogram relates here to the dimensions of the pictogram itself, and not 
to the size of the virtual square within which the pictogram is placed. 

 
 
 
 
 
 
 
                                                 
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Below is the exclamation mark (pictogram GHS07) as an example pictogram. This 
is assigned to various health hazard classes and categories of lower severity, see 
Part 2 of Annex V to CLP: 

Printable pictograms are provided free of charge for download at 
http://www.unece.org/trans/danger/publghs/pictograms.html.  

4.3.3 Precedence rules  

For substances and mixtures classified for more than one hazard, several 
pictograms may be required on the label. In such cases, the applicability of the 
precedence rules set out in CLP Article 26 needs to be checked. As a general rule, 
the pictograms which reflect the most severe hazard category of each hazard 
class must be included on the label. This would also apply where a substance has 
both a harmonised and a non-harmonised (i.e. self-) classification, see CLP Article 
26(2). 

Further  to  this,  CLP  sets  out  precedence  rules  relating  to  particular  hazard 
pictograms and classifications: 

  For physical hazards, if the label carries the pictogram GHS01 (exploding 

bomb), then GHS02 (flame) and GHS03 (flame over circle) are optional …  

   mandatory               optional 

             optional 

… except in cases where more than one pictogram is compulsory, namely for 
substances and mixtures classified as self-reactive Type B or as organic 
peroxide Type B, see Annex I to CLP; 

  For physical and health hazards, if the label carries the pictogram GHS02 

(flame) or GHS06 (skull and crossbones), then GHS04 (gas cylinder) is 
optional21:  

or 

                mandatory               mandatory              optional 

21 This precedence rule was introduced by the Commission Regulation (EU) No 286/2011 of 
10 March 2011 (2nd ATP to the CLP Regulation). 

 
 
 
 
 
 
 
                    
              
             
 
 
 
 
 
                
 
  
                                                 
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  For health hazards, if the label carries the pictogram GHS06 (skull and 

crossbones), then GHS07 (exclamation mark) must not appear: 

 

For  health  hazards,  if  the  label  carries  the  pictogram  GHS05  (corrosion), 
then GHS07 (exclamation mark) must not be used for skin or eye irritation… 

… but still has to be used for other hazards. 

 

For health hazards, if the label carries the pictogram GHS08 (health 
hazard) for respiratory sensitisation, then GHS07 (exclamation mark) must 
not be used for skin sensitisation or for skin or eye irritation … 

… but still has to be used for other hazards. 

In case a substance or mixture is assigned the supplemental hazard statement 
EUH071 (“Corrosive to the respiratory tract”), a corrosivity pictogram (GHS05) 
may be assigned, see Note 1 of Table 3.1.3 of Annex I to CLP. Where this is done, 
the pictogram GHS07 (exclamation mark) for STOT, single exposure, category 3 
(respiratory tract irritation) must be omitted from the label, as well as the hazard 
statement H335 (May cause respiratory irritation).  

For substances and mixtures that have to be labelled both in accordance with the 
CLP Regulation and with the rules on the transport of dangerous goods, the CLP 
pictogram(s) may be omitted from the label where the CLP pictogram(s) relates 
to the same hazard as in rules for transport (sub-section 5.4 of this guidance). 

4.3.4 Blank pictograms  

When preparing hazard labels, a common practice is to use pre-printed label 
stocks of the diamonds (the label background is printed first before it is 
overprinted with the specific label information). This may result in labels with a 
number of pre-printed empty diamonds, not all of which may then be needed by 
a company that has purchased pre-printed labels. In such a situation one or more 
pre-printed diamonds may have to be left empty.  

 
 
 
 
 
   
                                          
  
 
 
    
   
    
  
           
 
 
 
 
                      
                                              
 
 
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CLP does not explicitly forbid blank diamonds. However, any information given in 
addition to the minimum mandatory labelling must not contradict or cast doubt 
on the mandatory label information (Article 25(3)), while empty red frames might 
raise questions. If empty red frames are unavoidable, it is recommended to cover 
them up with a solid overprint which blacks them out completely, see the 
example in Figure 3.  

Figure 3. Blackened out empty diamonds 

Blacking-out of empty diamonds aims to avoid the impression that relevant 
hazard symbols may have been left off the label through a printing mistake.  

Please refer also to CLP FAQ ID=240 available at 
http://echa.europa.eu/support/qas-support/qas.  

4.4 Signal words 

A signal word indicates the relative level of severity of a particular hazard. The 
label must include the relevant signal word in accordance with the classification of 
the hazardous substance or mixture: more severe hazards require the signal word 
‘Danger’ while less severe hazards require the signal word ‘Warning’, see CLP 
Article 20.  

The signal word relevant for each specific classification is set out in the tables 
indicating the label elements required for each hazard class as set out in parts 2 
to 5 of Annex I to CLP. Some hazard categories, like explosives, division 1.6, do 
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Where a substance or mixture is classified for more than one hazard, the label 
must only bear one single signal word. In such cases, the signal word ‘Danger’ 
takes precedence and the signal word ‘Warning’ must not appear. 

4.5 Hazard statements 

CLP hazard labels must also bear the relevant hazard statements describing the 
nature and severity of the hazards of a substance or mixture, see CLP Article 21.  

The hazard statements relevant for each hazard class and category/differentiation 
are set out in the tables contained in parts 2 to 5 of Annex I to CLP. An example 
is the hazard statement H302 (Harmful if swallowed) assigned to acute oral 
toxicity, category 4. The wording for hazard statements is given in Tables 1.1, 1.2 
and 1.3 of Annex III to CLP.  

In some cases additional information to complement a hazard statement22 may 
need to be provided, such as the specification of the route of exposure or of the 
target organ for certain health hazards, i.e. for the CMR and the STOT single and 
repeated exposure hazard classes. For example: 

o 

for the STOT-RE, category 1 the hazard statement H372 (Causes damage 
to organs through prolonged or repeated exposure) must be 
complemented by the organs affected if known and by the route of 
exposure if it is conclusively proven that no other routes of exposure cause 
the hazard, e.g. H372 (Causes damage to the liver through prolonged or 
repeated dermal exposure); 

o 

for the STOT-SE, category 1 the route of exposure or the target organ 
may have to be included in the statement as well, e.g. H370 (Causes 
damage to the liver via ingestion).  

If a substance classification is harmonised and included in Part 3 of Annex VI to 
CLP, the corresponding hazard statement(s) relevant for this classification have to 
be used on the label. Note that certain harmonised classifications marked with an 
asterisk in Part 3 of Annex VI to CLP are minimum classifications, and based on 
available data a more severe classification as well as the corresponding hazard 
statement may need to be assigned. Also, hazard statements may need to be 
included for non-harmonised hazards classes or differentiations which are not 
covered in the Annex VI listing for the same substance, see CLP Article 4(3). 

Table 1.2 of Annex III to CLP defines which combined hazard statements are 
allowed23. Currently, combinations are allowed for acute toxicity hazard 
statements which relate to different routes of exposure, but to the same 
category. Such statements can appear on the label and in the SDS, for example: 
for category 3 for the oral and dermal route H301+H311 (Toxic if swallowed or in 
contact with skin).  

If a substance or mixture is classified in several hazard classes or differentiations 
of a hazard class, all hazard statements resulting from the classification must 
appear on the label, unless there is evident duplication or redundancy, see CLP 
Article 27. This also applies to a substance or mixture which is assigned the 

22  Please  note  that  this  does  not  constitute  supplemental  labelling  information  in  the 
meaning of CLP Article 25. It is rather additional hazard information which is required to be 
included within the hazard statement itself, beyond the standardised wording. 

23 Commission Regulation (EU) No 286/2011 of 10 March 2011 

 
 
 
 
                                                 
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supplemental hazard statement EUH071 (Corrosive to the respiratory tract)24. In 
this case, the hazard statement H335 (May cause respiratory irritation) for STOT, 
single exposure, category 3 (respiratory tract irritation) must be omitted from the 
label. 

The correct wording of the hazard statements as it has to appear on the label is 
given in CLP Annex III, in all EU languages. The hazard statements of one 
language must be grouped together with the precautionary statements of the 
same language on the label (sub-section 3.3 of this guidance). 

4.6 Precautionary statements   

CLP hazard labels must bear the relevant precautionary statements giving advice 
on measures to prevent or minimise adverse effects to human health or the 
environment arising from the hazards of a substance or mixture, see CLP Article 
22. An example is the precautionary statement P373 (DO NOT fight fire when fire 
reaches explosives). The complete set of precautionary statements relevant for 
each hazard class and category/differentiation is listed by alphanumeric code in 
the tables indicating the label elements required for each hazard class in parts 2 
to 5 of Annex I to CLP.   

Precautionary statements must be selected in line with the provisions set out in 
CLP Article 22 and 28 and with Part 1 of Annex IV to CLP: any selection must take 
into account the hazard statements used, the intended or identified use or uses of 
the substance or mixture as well as the basic instructions specified in the 
“conditions for use” columns in tables 6.1 – 6.5 of Annex IV to the CLP 
Regulation. Duplication and redundancy should be avoided. Where the substance 
or mixture is supplied to the general public, one precautionary statement 
addressing the disposal of that substance or mixture as well as the disposal of 
packaging must in general25 appear on the label, see CLP Article 28(2). Normally, 
not more than six precautionary statements must appear on the label, unless 
necessary to reflect the nature and the severity of the hazards (Example C in 
sub-section 7.4 of this guidance). 

For assistance with the selection of the most appropriate P-statements, please 
refer to section 7 of this guidance. 

Part 2 of Annex IV to CLP lists, in all EU languages, the correct wording of the 
precautionary statements as it must appear on a label. In case of different 
translations of P-statements, the translation in national version of CLP usually 
gives the most relevant wording. The precautionary statements of one language 
have to be grouped together with the hazard statements of the same language on 
the label (sub-section 3.3 of this guidance). 

24 See also  Note 1, Table 3.1.3 of Annex I to CLP 

25 In all other cases, a P-statement addressing disposal is not required, where it is clear 
that the disposal of the substance or mixture or the packaging does not present a hazard 
to human health or the environment. 

 
 
 
 
                                                 
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4.7 Codes for hazard and precautionary statements   

Hazard and precautionary statements are codified using a unique alphanumerical 
code which consists of one letter and three numbers, as follows: 

 

 

 

 

the letter “H” for “hazard statement” or “P” or “precautionary statement”;  

for hazard statements, the first digit designating the type of hazard: physical 
hazards 2, health hazards 3 and environmental hazards 4 and following two 
digits corresponding to the sequential numbering of hazards, such as 
explosivity (codes from 200 to 210), flammability (codes from 220 to 230), 
etc. 

risk phrases carried through from DSD and DPD, but which are not yet 
included in the GHS are codified as “EUH”; 

for precautionary statements, a digit reflecting one of five types of 
statements, namely general statements (1), prevention statements (2), 
response statements (3), storage statements (4) and disposal statements (5), 
followed by two digits for the sequential numbering of the statements 
themselves. 

The code ranges for the hazard and precautionary statements under CLP are set 
out in Table 4 below: 

Table 4:  Code ranges of hazard and precautionary statements under CLP 

Hazard  Statements: H 

Precautionary Statements: P 

200 – 299  Physical hazard 

100 – 199  General 

300 – 399  Health hazard 

200 – 299  Prevention 

400 – 499  Environmental hazard 

300 – 399  Response 

400 – 499  Storage 

500 – 599  Disposal 

The codes of the hazard and precautionary statements and EUH statements are 
not necessary for the label. The CLP Regulation only requires the actual phrasing 
of the applicable statements on the label. 

4.8 Supplemental labelling information  

CLP Article 25 defines the concept of ‘supplemental information’ which is intended 
to incorporate additional labelling information over and above that listed in CLP 
Article 17(a) to (g). This additional labelling information can be divided into two 
categories, namely obligatory and non-obligatory information. Please note that 
according to Article 25(6) supplemental labelling information might be obligatory 
for a mixture, even if not classified as hazardous.  

All ‘supplemental information’ must be located in the section for supplemental 
information on the label. Both obligatory and non-obligatory supplemental 
information have to appear in the same languages as the other CLP label 
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As it is obligatory to place this information alongside the label elements required 
by CLP Article 17(a) to (g), these supplemental label elements need to be 
considered carefully as to the location and the space they need when preparing a 
CLP label for a substance or mixture (see also Example 3 under section 6 of this 
guidance).  

Obligatory supplemental information, when applied, must be easy to 
identify and to read. Naturally, it has precedence over any non-obligatory 
supplemental information if space on the label is limited.  

4.8.1 Obligatory supplemental labelling information  

Obligatory supplemental labelling information includes:  

  Supplemental hazard statements relating to particular physical and health 

properties. These are codified as “EUH” statements, i.e. EUH001 
(Explosive when dry). For some substances with harmonised 
classifications, the supplemental hazard statements are included in Part 3 
of Annex VI; 

  Supplemental statements for certain mixtures, e.g. the EUH204 (Contains 
isocyanates. May produce an allergic reaction), see Part 2 of Annex II to 
CLP. These phrases are assigned EUH codes as well, to align their 
presentation with the supplemental hazard statements, see above;  

  The supplemental statement EUH401 (To avoid risks to human health and 
the environment, comply with the instructions for use) for hazardous 
substances and mixtures within the scope of Directive 91/414/EEC26 (see 
Part 4 of Annex II); 

  Label elements resulting from other EU acts (see CLP Article 32(6)), for 

example:  

– 

– 

– 

– 

– 

the authorisation number requested by the REACH Regulation,  

the listing of surfactants and perfumes according to the Regulation 
(EC) No 648/2004 on detergents, as amended,  

the  authorisation  number  of  the  biocidal  product  according  to  the  
Biocidal Products Regulation (EU) No 528/2012, 

the flammability labelling according to the Aerosol Dispensers 
Directive 75/324/EEC (ADD), as amended or  

the content of volatile organic compounds (VOC) in accordance with 
Directive 2004/42/EC27. 

26 Repealed by Regulation (EC) No 1107/2009 of the European Parliament and of the 
Council of 21 October 2009 concerning the placing of plant protection products on the 
market with effect from 14 June 2011.  

27 Directive 2004/42/EC of the European Parliament and of the Council of 21 April 2004 on 
the limitation of emissions of volatile organic compounds due to the use of organic solvents 
in certain paints and varnishes and vehicle refinishing products and amending Directive 
1999/13/EC. 

 
 
 
 
 
 
                                                 
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Further additional obligatory information can include:  

  Specific response information as referred to in the brackets of the 

precautionary statements P320 “Specific treatment is urgent (see … on 
this label)”, P321 “Specific treatment (see … on this label)” in Annex IV to 
CLP, e.g. “see supplemental first aid instructions on this label” or “see 
supplemental instructions on the administration of antidotes on this label”. 
See also Table 5 below and the selection tables (sub-section 7.3 of this 
guidance); 

  For mixtures containing components of unknown acute toxicity at a 

concentration of 1% or greater, the statement “x percent of the mixture 
consists of component(s) of unknown acute toxicity” (see point 3.1.3.6.2.2 
of Annex I to CLP). This statement also has to be included in the SDS, 
when this is provided28. In addition, it may be appropriate to differentiate 
the hazard based on the route of exposure. For example: “x percent of the 
mixture consists of ingredient(s) of unknown acute 
(oral/dermal/inhalation) toxicity”, in particular where the substance is also 
classified for other hazards and where it is important to specify the route 
of exposure (see also Guidance on the application of the CLP criteria); 

  For mixtures where no useable information on the acute and/or long-term 
hazard to the aquatic environment is available for one or more of the 
relevant components, the statement “Contains x percent of components 
with unknown hazards to the aquatic environment”, see point 4.1.3.6.1 of 
Annex I to CLP. This statement has to be included on the label and in the 
SDS; 

CLP requires supplemental label information to be located in a specific, 
supplemental information section on the label. A supplier may also choose to 
place the supplemental information in several locations, taking into account the 
requirements of CLP Article 25. See Example 3 and Example 5 in section 6 of this 
document.  

Similarly, the section for supplemental label information should be visibly 
separated from the labelling elements according to CLP Article 17(a) to (g), e.g. 
by placing it in another section of the label, by putting it in a text box, by colour 
or by different letter size. However, on a case-by-case basis, it may not be 
advisable to make a visible differentiation between the CLP elements and 
obligatory supplemental labelling information that is requested by other 
legislation, where the latter supports the safe handling and use of a substance or 
mixture. For example, where additional EUH statements express a similar warning 
as contained in the hazard statements which reflect a classification, it is even 
advisable to group both statements together on the label so that they reinforce 
each other. For example: for lithium (EC No 231-102-5) which is classified as 
water-reactive category 1, the hazard statement EUH014 (“Reacts violently with 
water.”) is very similar to H260 (“In contact with water releases flammable gases 
which may ignite spontaneously.”), see Example 4 in section 6 of this guidance. 

In relation to readability, obligatory labelling information required by other EU 
legislation (e.g. the content of volatile organic compounds as required by 
Directive 2004/42/EC or the listing of specified constituents as required by 

28 For further information on the compilation of the SDS, please consult the Guidance on 
the compilation of safety data sheets (http://echa.europa.eu/guidance-
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Regulation (EC) No 648/2004) must not be treated differently from other 
obligatory labelling information required by CLP itself. Obligatory information 
must be easy to identify and read and must take precedence on the CLP label 
over any other non-obligatory supplemental information. An overview of the 
obligatory supplemental label elements to be included in the section for 
supplemental information on the label is provided in Table 5. 

Table 5: Obligatory supplemental labelling information pursuant to CLP 
Articles 25 and 32 

Legal Reference 

Type and Applicability 

Code 

Content / Phrasing 

CLP Article 
25(1) and Annex 
II, Part 1, 
section 1.1 

a) 

Supplemental hazard statements relating to certain physical 
properties of substances and mixtures. They need to be assigned in 
accordance with the conditions specified in Annex II when a 
substance or mixture has already been classified on the basis of the 
criteria in Annex I to CLP. For some substances with harmonised 
classifications, supplemental hazard statements are included in Part 
3 of Annex VI. 

EUH001 

‘Explosive when dry’ 

EUH014 

‘Reacts violently with 
water’  

EUH018 

‘In use, may form 
flammable/ explosive 
vapour-air mixture’ 

EUH019 

‘May form explosive 
peroxides’ 

EUH044 

‘Risk of explosion if 
heated under 
confinement’ 

CLP Article 
25(1) and Annex 
II, Part 1, 
section 1.2 

b) 

Supplemental hazard statements relating to health properties of 
substances and mixtures. They need to be assigned in accordance 
with the conditions specified in Annex II, Part 1, section 1.2 when a 
substance or mixture has already been classified on the basis of the 
criteria in Annex I to CLP. For some substances with harmonised 
classifications, supplemental hazard statements are included in Part 
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EUH029 

‘Contact with water 
liberates toxic gas’ 

EUH031 

‘Contact with acids 
liberates toxic gas’ 

EUH032 

‘Contact with acids 
liberates very toxic gas’ 

EUH066 

‘Repeated exposure may 
cause skin dryness or 
cracking’ 

EUH070 

‘Toxic by eye contact’ 

EUH071 

‘Corrosive to the 
respiratory tract’ 

CLP Article 
25(6) and Annex 
II, Part 2 

Supplemental statements for certain mixtures. They need to be assigned 
to mixtures in accordance with the conditions specified in Annex II, Part 
2. 

1.  Mixtures containing lead 

EUH201 

‘Contains lead. Should not 
be used on surfaces liable 
to be chewed or sucked 
by children’ 

–  for packaging content 
less than 125 ml 

EUH201A 

‘Warning! Contains lead’. 

2.  Mixtures containing 
cyanoacrylates 

EUH202 

‘Cyanoacrylate.  
Danger.  
Bonds skin and eyes in 
seconds.  
Keep out of the reach of 
children.’ 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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3.  Cement and cement 

EUH203 

mixtures 

4.  Mixtures containing  

EUH204 

isocyanates 

‘Contains chromium (VI). 
May produce an allergic 
reaction’ 

‘Contains isocyanates.  
May produce an allergic 
reaction’ 

5.  Mixtures containing 

EUH205 

epoxy constituents with 
an average molecular 
weight ≤ 700 

‘Contains epoxy 
constituents. May produce 
an allergic reaction’ 

6.  Mixtures sold to the 
general public which 
contain active chlorine 

EUH206 

7.  Mixtures containing 

EUH207 

cadmium (alloys) and 
intended to be used for 
brazing or soldering 

8.  Mixtures not classified as 

EUH208 

sensitising but 
containing at least one 
sensitising substance29 

‘Warning!  
Do not use together with 
other products.  
May release dangerous 
gases (chlorine)’ 

‘Warning!  
Contains cadmium. 
Dangerous fumes are 
formed during use.  
See information supplied 
by the manufacturer.  
Comply with the safety 
instructions.’ 

‘Contains (name of 
sensitising substance). 
May produce an allergic 
reaction’ 

9.  Liquid mixtures 

EUH209 

containing halogenated 
hydrocarbons 

EUH209A 

‘Can become highly 
flammable in use 
or 
Can become flammable in 
use’ 

10.  Mixtures not intended 
for the general public 

EUH210 

‘Safety data sheet 
available on request’ 

29 According to Commission Regulation (EU) No 286/2011 (2nd ATP to the CLP Regulation), 
mixtures classified as sensitising containing other substance(s) classified as sensitising (in 
addition to the one that leads to the classification of the mixture) and present in a 
concentration equal to or greater than that specified in Table 3.4.6 of Annex I to CLP must 
bear the name(s) of that/those substance(s) on the label. Note that EUH208 must be used 
also when a non-classified mixture contains sensitising substances. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
                                                 
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32 

CLP Annex IV 

11.  Aerosols 

Substances and mixtures 
assigned the precautionary 
statements 

-  P320 - Specific treatment 
is urgent (see … on this 
label). 

-  P321 - Specific treatment  

(see … on this label). 

CLP Annex I, 
section 
3.1.3.6.2.2. 

Mixture containing 
ingredient(s) of unknown 
acute toxicity at a 
concentration at 1% or 
greater 

CLP Annex I, 
section 4.1.3.6.1 

Mixture where no useable 
information on the acute 
and/or long-term aquatic 
hazard is available for one 
or more of the relevant 
components 

Aerosols are also subject 
to the labelling provisions 
of Directive 75/324/EEC 

Supplemental first aid 
instruction (e.g. 
administration of an 
antidote or immediate 
measures such as specific 
cleansing agent) referred 
to in the brackets of the 
precautionary statements 

‘x percent of the mixture 
consists of component(s) 
of unknown acute toxicity’ 
(also for safety data 
sheet) 

‘Contains x percent of 
components with 
unknown hazards to the 
aquatic environment’. 
(also for safety data 
sheet) 

CLP Article 
25(2)  

Supplemental statement for 
substances and mixtures 
within the scope of Directive 
91/414/EEC30  

EUH401 

‘To avoid risks to human 
health and the 
environment, comply with 
the instructions for use’. 

30 Repealed by Regulation (EC) No 1107/2009 of the European Parliament and of the 
Council of 21 October 2009 concerning the placing of plant protection products on the 
market with effect from 14 June 2011. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
                                                 
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Examples: 

-  Regulation (EC) No 

1907/2006 (REACH) 

-  Regulation (EC) No 

648/2004 (detergents) 

Label elements 
resulting from 
other 
Community acts 
pursuant to CLP 
Article 32(6) 

-  Directive 75/324/EEC on 
aerosol dispensers (AAD) 

-  Directive 2004/42/EC on 

volatile organic 
compounds (VOC) 

-  Biocidal Products 

Regulation (EU) No 
528/2012  

-  authorisation number 

- 

- 

labelling statements 
related to restrictions 
in Annex XVII of  
REACH, e.g. 'Restricted 
to professional users' 

listing of specified 
constituents such as 
anionic surfactants, 
oxygen bleaching 
agents, enzymes, 
disinfectants, optical 
brighteners and 
perfumes 

- 

flammability labelling 

-  content of volatile 

organic compounds 

-  authorisation number 
of the biocidal product 

4.8.2 Non-obligatory supplemental labelling information 

In some cases suppliers may need to include certain elements on the label which 
are not obligatory, but are necessary for the handling and use of the product, for 
example specific product information, basic instructions for use or P-statements 
which do not arise directly from the classification of the product (e.g. ‘Read label 
before use’ or ‘Do not get in eyes’ – for eye irritant mixtures). Such non-
obligatory supplemental labelling information, the content of which is up to the 
discretion of the supplier, is not part of the labelling requirements under CLP.  

The need for non-obligatory information should also be taken into account when 
deciding how to lay out the label. The non-obligatory supplemental information 
may also be placed alongside the label elements required in CLP Article 17(a) to 
(g) and the obligatory supplemental information, when applied. However, such 
information must not be confusing to the user or contradict the obligatory label 
elements. It should also provide further necessary details, see CLP Article 25(3).  

Additional labelling elements which come from the UN GHS but are not 
implemented in CLP may be included in the section for non-obligatory 
supplemental information, but they must not confuse the user. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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In addition, any non-obligatory supplemental information, either included on the 
label or on the packaging, must be consistent with the classification of the 
substance or mixture, see CLP Article 25(4). This means that statements such as 
‘non-toxic’, ‘non-polluting’ or ‘ecological’, or other statements suggesting that the 
substance/mixture is not hazardous or statements that are incompatible with the 
assigned classification must not appear on the label or packaging of a classified 
substance or mixture. 

5. Guidance on particular aspects of CLP hazard 
labelling 

5.1 Further aspects to consider for the CLP hazard label 

To enable the supplier to design labels in compliance with CLP while at the same 
time allowing for as much freedom in arranging labels as possible, further 
labelling aspects should be considered.  

–  Label size: CLP defines minimum dimensions for the size of the label and 

some of its elements (see sub-section 5.2 of this guidance); 

–  Specific labelling rules that refer to specific labelling and packaging 

situations, for example: 

–  a substance or mixture is contained in awkwardly shaped or 

small packaging, see CLP Article 29.  

–  the packaging consists of multiple layers and/or  

–  a substance or mixture is subject to the labelling provisions of the 
CLP Regulation and to labelling provisions in accordance with 
the rules on the transport of dangerous goods according to 
the UN Recommendations on the Transport of Dangerous Goods – 
Model Regulations (the so-called "Orange Book")31. The person 
responsible for compiling a CLP label needs to consider all of these 
rules before making a final decision on the label of the substance or 
mixture, see CLP Article 33; 

–  Selection of precautionary statements:  

The selection of the most appropriate set of precautionary statements for 
the label is largely at the discretion of the supplier. Please refer to section 
7 of this guidance.  

5.2 Size of the label and of the label elements 

Section 1.2 of Annex I to CLP defines the label size, setting out minimum 
dimensions for the label, with the pictogram size being linked to these minimum 
dimensions (see also Table 6 below). Nevertheless, the label should be large 
enough to contain all the label elements defined by CLP while remaining legible. 
As a result, the label may need to be larger than the minimum area specified. 

31 Implemented in the EU through international modal agreements and Directive 
2008/68/EC. 

 
 
 
 
 
 
 
 
 
 
 
                                                 
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Table 6: Minimum dimensions of labels and pictograms under CLP 

Capacity of the package 

Dimensions of the label  
(in millimetres) for the 
information required by 
Article 17 

Dimensions of the 
pictogram (in 
millimetres) 

≤ 3 litres 

If possible, at least 52 x 74 

Not smaller than 10 x 10 
If possible, at least 16 x 16 

> 3 litres but ≤ 50 litres 

At least 74 x 105 

At least 23 x 23 

> 50 litres but ≤ 500 litres 

At least 105 x 148 

At least 32 x 32 

> 500 litres 

At least 148 x 210 

At least 46 x 46 

CLP requires that the label elements as referred to in CLP Article 17(1) be of such 
size and spacing as to be easily read. Readability is determined by the 
combination of font size, letter spacing, spacing between lines, stroke width, type 
colour, typeface, width-height ratio of the letters, the surface of the material and 
significant contrast between the print and the background. 

Figure 4: Readability 

A label may accommodate more language(s) than those required by the Member 
State where the substance or mixture is placed on the market. As long as the 
label complies with the (minimum) dimensions set out in Table 6 above and as 
long as legibility of the text elements is warranted, the decision on the number of 
languages is at the discretion of the respective supplier. 

The exact size of the letters of the signal words, hazard statements, 
precautionary statements and any supplemental information is not further defined 
in the legal text, i.e. it is left to the discretion of the supplier to determine the 
size of the letters that allow the label elements to be easily read. However, the 
minimum letter size of 1.2 mm (‘x-height’) can be used as a reference. A supplier 
may decide whether he wants to increase the letter size with the overall volume 
of the packaging and dimensions of the label, or to fix it more or less for all 
volumes and labels. 

Similarly, a supplier may decide whether he prefers to have larger letter sizes for 
certain label elements while others are presented in smaller letters. Practical 
solutions often chosen are for example:  

–  providing the signal word “Danger” or “Warning” in larger letters on the 

label than the hazard and precautionary statements,  

–  presenting the obligatory label elements in larger letters than the non-

obligatory labelling information.  

 
 
 
 
 
 
 
 
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Both abovementioned solutions are in principle compatible with the CLP legal text 
as long as the obligatory information on the label can be easily read. 

CLP links the size of the hazard pictograms to the minimum dimensions of the 
label. Each hazard pictogram32 must cover at least one fifteenth of the minimum 
surface area of the label dedicated to obligatory labelling information. The 
minimum dimensions of labels and pictograms are given  in Table 1.3 of Annex I. 
The minimum area of the pictogram must not be less than 1 cm2. The pictogram 
size can be increased from the minimum dimensions where the actual label size 
allows this. The idea behind this is that the label size and the size of the 
pictograms should remain proportional to the size of the packaging. 

A pictogram covering one fifteenth of the minimum surface area obtained by 
multiplying the dimensions as defined in Table 1.3 of Annex I to CLP is considered 
to be legible. The pictogram size has to be increased in all cases where it occupies 
less than one fifteenth of the surface area of the label dedicated to the obligatory 
labelling information (point 1.2.1.3 of Annex I to CLP). However, where a supplier 
chooses to use a label that is larger than the minimum dimensions for a certain 
capacity of the package, it is not necessary to increase also the size of the 
pictogram, provided it covers one fifteenth of the relevant minimum dimensions 
required by Article 17. 

Example:  
For a container of a capacity > 50 litres, but ≤ 500 litres, the minimum size of a 
pictogram must be 32 mm x 32 mm, which is one fifteenth of the area obtained 
by multiplying the minimum dimensions (105 mm x 148mm).  (105 mm x 148 
mm = 10.5 cm x 14.8 cm = 155.5 cm2. Then one fifteenth of 155 cm2 = 10.36 
cm2; √10.36 cm2 = 3.22cm = 32.2mm (rounded to 32 mm) for each dimension of 
each pictogram). 

If the label increases while the capacity of the container remains the same (> 50 
litres, but ≤ 500 litres) the minimum size of each pictogram should be at least 
one fifteenth of the area related to obligatory information required by Article 17.  

In principle, a label complying with the minimum dimensions set out above should 
be large enough to contain all the label elements defined in CLP Article 17 while 
remaining legible. Precedence must be given to the obligatory label elements and 
any obligatory supplemental information required by CLP and other EU legislation. 
If a supplier chooses to add non-obligatory supplemental label elements, legibility 
may be affected when more than just a small amount of such information is 
added. For larger amounts of non-obligatory information the supplier should 
consider limiting this information or increasing the size of the label. When the size 
of the label is increased, the supplier should also consider increasing the size of 
the different obligatory label elements. This should serve the purpose of 
facilitating their identification and maintaining their legibility. 

Any additional area gained by increasing the size of the label can be used for 
further information which is considered important by the supplier. However, this 
should be weighed against the requirement of CLP Article 25(3), namely that non-
obligatory supplemental information must not make it more difficult to identify 
the obligatory label elements. 

32 The size of the pictogram relates here to the dimensions of the pictogram itself, and not 
to the size of the virtual square into which the pictogram is placed. 

 
 
 
 
 
                                                 
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5.3 Exemptions from the labelling and packaging 
requirements 

Not all packages allow the necessary labelling information on the label or on the 
packaging to be displayed in line with the requirements of CLP Article 31.  

CLP Article 29(1) and section 1.5.1 of Annex I provide derogations for packaging 
which is so small or in such a shape or form that it is impossible to meet the 
requirements of CLP Article 31.  

If the provisions of Article 29(1) cannot be applied, CLP Article 29(2) and section 
1.5.2 of Annex I allow the omission of certain label elements (see sub-section 
5.3.2 of this guidance). 

5.3.1 Use of fold-out labels, tie-on tags and outer packaging 

The packaging of a substance or mixture can be so small or in such a shape or 
form that it is impossible to display the label elements in line with the 
requirements of CLP Article 31. This could either be because the Member States 
where the substance or mixture is being placed on the market require more than 
one language on the label, or simply because the packaging is too small or 
difficult to label because of its form/shape so that the full range of labelling 
elements even in a single language cannot be displayed.  

In particular, it may be impossible for the label to be read horizontally when the 
package is set down normally or the label elements are of insufficient size and 
spacing as to be easily read.  

In this situation the label elements defined under CLP Article 17 may be provided 
either on  

 

 

fold-out labels; or 

tie-on tags; or 

  outer packaging. 

Where one of the abovementioned alternatives is used, the label on any inner 
packaging or the part of the fold-out label which is directly attached to the 
packaging, must contain at least: the hazard pictogram(s), the product identifier 
referred to in CLP Article 18 and the name and telephone number of the supplier 
of the substance or mixture. In this case the signal word, the hazard and 
precautionary statements as well as the supplemental label information may be 
omitted.  

However, the use of the alternatives given in the above bullet points is not 
allowed where a label becomes unreadable only because the supplier wishes to 
add more languages on a label than are required in the Member States where the 
substance or mixture is placed on the market.  

 
 
 
 
 
 
 
 
 
 
 
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5.3.1.1 Fold-out labels and tie-on tags 

When a supplier recognises the need to use fold-out labels or tie-on tags, he 
should consider the following aspects: 

General requirements for fold-out labels and tie-on tags 

The CLP Regulation does not foresee any separate provisions for tie-on tags or 
fold-out labels. Both types of label must meet the same performance standards 
as any other “normal” label, namely: 

  the label elements must be indelible, easy to read and stand out from the 

background;  

  the size of the pictograms must be the same as the pictograms on the 

equivalent, normal label. 

The fold-out label or tie-on tag must be securely attached to the packaging, i.e. 
the label remains attached to the packaging during reasonably expected handling 
of the package.  

At least the following CLP information must be firmly attached to the immediate 
container:  

  hazard pictograms,  

 

 

the product identifier and  

the name and telephone number of the supplier of the substance or 
mixture. 

Compared to tie-on tags, the use of fold-out labels will probably be the preferred 
option as this will offer most space for the label elements in many cases. Some 
information relating to the content, quality and design of a fold-out label is given 
below. See also Example 6 of this guidance where a multilingual, fold-out label 
for a mixture for supply and use is presented. 

Fold-out labels can also be an option (and are in fact commonly used) where the 
amount of obligatory supplemental labelling information required by other 
legislation would result in a label that is too large for the packaging. Fold-out 
labels may help to clearly structure the labelling information by using different 
pages for different types of information (see below). 

Content, quality and design of a fold-out label 

Content 

A fold-out label generally consists of three parts, namely the front page (top 
leaf), inside page(s) and the back page (firmly attached to the packaging).  

The label elements and information required by CLP Articles 17 and 32(6) should 
be included on the fold-out label in a way as described below. In accordance with 
Article 29(1) CLP, the labelling information can only be provided using fold-out 
labels where it is not possible to meet the requirements of Article 31 for a label in 
the languages of the Member State in which the substance or mixture is placed 
on the market. 

 
 
 
 
 
 
 
 
 
39 

  The front page must contain at least: 

Guidance on Labelling and Packaging 

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o 

the product identifier (Article 18(2) for substances, Article 18(3)(a) 
for mixtures); Please note that for mixtures, the product identifier 
on the front and back page does not need to specify all the 
components contributing to the classification of the mixture; 

o  hazard pictogram(s) (Article 17(1)(d)); 

o  signal words in all languages of the label (Article 17(1)(e); 

o  nominal quantity (packages made available to the general public, 
unless specified elsewhere in the package) (Article 17(1)(b)); 

o  contact details of supplier(s) (name, address and phone number) 

(Article 17(1)(a)); 

o  a reference to the full safety information inside the fold-out label, 

for example: “safety information, see inside” in all languages of the 
label or a symbol to inform a user that the label can be opened and 
to illustrate that additional information is available on inside pages 
(not in Article 17(1)); 

o  an abbreviation of the language (country code or language code); 

to avoid non-standard or confusing abbreviations it is 
recommended to use the language code according to e.g. ISO 639-
1; 

  Inside page(s) should contain: 

o 

full labelling information (except for the hazard pictogram and the 
supplier identification) as required by Article 17(1) of CLP (including  
supplemental information) for each language mentioned on the 
front page and grouped by language, for example one language per 
page;  

o  an abbreviation of the language featured at the top of each of the 

inside pages (country code or language code). 

  The back page should repeat the information given on the front page, 
except for the indication of the different languages in the inner layers. 

Quality and design 

There is no standard specified in CLP for label materials and performance of fold-
out labels. However, sufficient quality of the fold-out label needs to be ensured.  
The exact manner in which this quality is ensured should be left to the discretion 
of the supplier, but attention should be paid to the following aspects: 

  Durability 

Taking into account the different situations that may occur during normal 
handling and use of the packaging (the contents of the package may 
dissolve the printing or the users may read the label several times), it is 
clear that the fold-out label must be sufficiently durable to maintain its 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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functionality under repeated use conditions (as applicable) for the entire 
life span of the product. This can be achieved for example by protective 
coating of the label and using plasticised pages.  

The back page of a fold-out label should be firmly attached to the 
packaging to resist normal handling and use. The pages should not be 
easily detachable from each other. 

  Readability 

The information in the fold-out label should be easily read. In the case of a 
booklet, page numbers can be considered. The languages should be 
ordered in a logical way, e.g. alphabetically. 

  Easy access to the information 

The information in the fold-out label should be easily accessible by 
allowing easy opening and reclosing of the label by the user. This can be 
ensured for example by using a "Pull tab” – a small area of the label which 
allows lifting it easily from its backing sheet. Easy access to the 
information (and readability) can also be improved by featuring one 
language per inner page of the fold-out label. 

5.3.1.2 Outer packaging 

When a packaging is too small or in such a form or shape that the labelling 
requirements of CLP Article 31 cannot be met, one of the options provided by 
Article 29(1) is to provide limited labelling information on the inner packaging 
while the full labelling information is provided on outer packaging. This may be 
useful in the case of many small units within one outer packaging. In such cases 
the requirements that normally apply to labels (see CLP Articles 31 and 32) will 
also apply to the label area on the outer packaging.  

When the outer packaging option is used, a distributor or retailer has to take care 
that all the label elements required by CLP are available when he places the 
single package units individually on the market. 

5.3.2 Omission of certain label elements 

In case it is impossible to meet the labelling requirements of Article 31 (because 
of the small size, shape or form) and the full label information33 cannot be 
provided in fold-out labels, on tie-on tags or on an outer packaging, the label 
information may be reduced subject to certain conditions specified in section 
1.5.2 of Annex I to CLP, namely for: 

  packages where contents do not exceed 125 ml and the substance or 

mixture is classified in one of the hazard categories listed in Table 7 below 
– this also refers to situations when a substance or mixture is re-filled into 
small volume bottles (125 ml or less) that are marketed afterwards, or 
where small volume bottles (125 ml or less) are no longer sold in outer 

33 i.e. the information required by Article 17 of CLP 

 
 
 
 
 
 
 
 
 
 
 
 
                                                 
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packaging, but individually (see also sub-section 5.3.2.1 of this guidance); 

 

soluble packaging for single use where contents do not exceed 25 ml (see 
also sub-section 5.3.2.2 of this guidance);  

Label information may also be adapted for: 

 

inner packaging of substances and mixtures for scientific research and 
development or quality control analysis where the contents do not exceed 
10 ml (see also sub-section 5.3.2.3 of this guidance); 

  unpackaged hazardous substances or mixtures supplied to the general 

public (see also sub-section 5.3.2.4 of this guidance); 

  environmental labelling (see also section 5.3.2.5 of this guidance).  

5.3.2.1 Labelling of packages where the contents do not exceed 
125 ml 

The label elements mentioned in column 2 of Table 7 may be omitted from the 
label of packages which do not exceed 125 ml of capacity where the substance or 
mixture is classified for the hazard classes or categories, as listed in column 1.  

However, where the substance or mixture is classified under further hazard 
classes not listed, the label elements related to these other hazard classes still 
need to be included. Please refer also to section 1.5.2.1 of Annex I to CLP. 

Table 7: Labelling exemptions for packages of a capacity of 125 ml or less 

Classification  
of the substance or mixture 

Allowed omissions according to 
section 1.5.2 of Annex I to CLP 

Oxidising gases cat. 1  (H270)  

Gases under pressure   (H281) 

Flammable liquids cat. 2 or 3  (H225, H226)   

Flammable solids cat. 1 or 2  (H228) 

Self-reactive substances or mixtures,  
types C, D, E or F  (H242) 

Self-heating substances or mixtures, cat. 2  (H252) 

Substances and mixtures which, in contact with water, emit 
flammable gases, cat. 1, 2 or 3  (H260, H261) 

Oxidising liquids cat. 2 or 3  (H272) 

Oxidising solids cat. 2 or 3  (H272) 

Organic peroxides, types C, D, E or F  (H242) 

hazard and precautionary 
statements for the hazard classes 
listed in  
column 1 

comment: the hazard pictogram 
and signal word are required for 
the denoted hazard categories 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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Acute toxicity cat. 4  (H302, H312, H332) 
(if the substance or mixture is not supplied to the general public) 

Skin irritation cat. 2 (H315) 

Eye irritation cat. 2 (H319) 

STOT-SE cat. 2 or 3 (H371, H335, H336) 
(if the substance or mixture is not supplied to the general public) 

STOT-RE cat. 2 (H373) 
(if the substance or mixture is not supplied to the general public) 

Hazardous to the aquatic environment - Acute cat. 1 (H400) 

Hazardous to the aquatic environment – Chronic cat. 1 or 2  
(H410, H411) 

Flammable gases cat.2 (H221) 

Reproductive toxicity: effects on or via lactation (H362) 

Hazardous to the aquatic environment - Chronic cat. 3 or 4 
(H412, H413) 

Corrosive to metals  (H290) 

precautionary statements linked to 
the hazard classes listed in column 
1 

comment: the hazard statements 
and signal word must be provided 
as no hazard pictogram is required 
for the denoted hazard categories 

hazard pictogram, signal word, 
hazard and precautionary 
statements for this hazard class 

It should be noted that the exemptions regarding the labelling of small packages 
of aerosols classified as flammable (Directive 75/324/EEC34) apply to aerosol 
dispensers.  

5.3.2.2 Labelling of soluble packaging for single use which does 
not exceed a volume of 25 ml 

The soluble packaging exemption applies to soluble packaging where the content 
does not exceed a volume of 25 ml. For such packaging the CLP label elements 
required by CLP Article 17 may be omitted provided the packaging is intended for 
single use and it is contained within an outer packaging that bears all label 
elements required under Article 17 of CLP.  

The exemption applies in cases where the substance or mixture contained is 
classified exclusively for one or more of the hazards categories in sections 
1.5.2.1.1 (b), 1.5.2.1.2 (b) or 1.5.2.1.3 (b) of Annex I to CLP (see Table 7 

34  Council  Directive  75/324/EEC  of  20  May  1975 on  the  approximation  of  the  laws  of  the 
Member  States  relating  to  aerosol  dispensers,  as  amended  by  Commission  Directive 
94/1/EC and Commission Directive 2008/47/EC.  

 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
                                                 
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above). However, this exemption does not apply to substances and mixtures 
within the scope of Regulation (EC) 1107/2009 (plant protection products) or 
Regulation (EU) No 528/2012 (biocidal products). 

5.3.2.3 Labelling of inner packaging where the contents do not 
exceed 10 ml 

The CLP label elements required by CLP Article 17 may be omitted from the inner 
packaging provided that all the following conditions are met: 

–  the content of inner packaging does not exceed a volume of 10 ml; 

–  the substance or mixture is placed on the market for supply to a 

distributor or downstream user for scientific research and development 
(SR&D)35 or quality control analysis; and 

–  the inner packaging is contained within an outer packaging that contains 

all label elements required by Article 17. 

However, it should be noted that the label on inner packaging must contain the 
product identifier and (if appropriate) the hazard pictograms; GHS01, GHS05, 
GHS06 and/or GHS08. In case more than two pictograms are assigned, GHS06 
and GHS08 may take precedence over GHS01 and GHS05. 

The exemption does not apply to substances and mixtures within the scope of 
Regulation (EC) 1107/2009 (plant protection products) or Regulation (EU) No 
528/2012 (biocidal products). 

5.3.2.4 Unpackaged hazardous substances or mixtures supplied to 
the general public 

Labelling information about unpackaged chemicals sold to the general public must 
be made available to the customer, e.g. on an invoice or bill, see CLP Article 
29(3). When the purchase of such substances or mixtures occurs at a different 
point in time than their delivery to the customer, one might also consider 
providing a leaflet which contains the relevant labelling information when 
delivering the substance or mixture, or sending the information electronically 
before or upon delivery. Article 29(3) provisions apply to substances listed in Part 
5 of Annex II to CLP).  

5.3.2.5 Environmental labelling 

CLP includes the possibility to introduce exemptions from certain provisions on 
environmental labelling for certain mixtures classified as hazardous to the 
environment where it can be demonstrated that there would be a reduction in the 
environmental impact, see CLP Article 29(4). However, no such exemptions or 
specific provisions have been agreed to date. Once determined in accordance with 
the procedure referred to in CLP Articles 53 and 54, such exemptions or specific 
provisions would be defined in Part 2 of Annex II to CLP. 

35 For more information on substances manufactured, imported or used in scientific 
Research and Development (SR&D) please consult ECHA Guidance on Scientific Research 
and Development (SR&D) and Product and Process Orientated Research and Development 
(PPORD). 

 
 
 
 
 
 
 
 
                                                 
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5.4 Interaction between the CLP and the transport labelling 
rules  

5.4.1 Specific rules for labelling of outer packaging, inner 
packaging and single packaging 

Article 33 of the CLP Regulation sets out specific rules for situations where the 
packaging of hazardous substances and mixtures is also required to meet the 
labelling provisions in accordance with the rules on the transport of dangerous 
goods. The transport labelling provisions are set out in the UN Recommendations 
on the Transport of Dangerous Goods – Model Regulations. Transport labelling as 
referred to in CLP Article 33 includes all labels and marks required by e.g. 
Directive 2008/68/EC36, for example the mark for environmentally hazardous 
substances, elevated temperature marks or limited/exempted quantities marks.  

A basic principle of CLP is not to override any labelling required by the transport 
rules while maintaining essential hazard information on the relevant layer(s) of 
packaging.  

CLP labelling is normally required on every inner and intermediate layer of the 
packaging of a substance or mixture; it may also appear on an outer packaging.  

Transport labelling will have to appear on the outer packaging of hazardous 
substances and mixtures if these are “dangerous goods” according to the rules on 
the transport of dangerous goods. The CLP label may then be omitted. 

Single packages need to carry both the CLP label elements and the transport 
labelling. If a CLP hazard pictogram on single or outer packaging relates to the 
same hazard as in the rules for the transport of dangerous goods, the CLP 
pictogram may be omitted to avoid unnecessary double labelling. 

While CLP may not require outer packaging to carry the CLP label elements where 
it already carries the corresponding transport labelling, a supplier may choose to 
apply to the outer packaging the full CLP label that is on the inner or intermediate 
packaging. This option may need to be considered where the substance or 
mixture is classified for a hazard that is not covered by the rules on the transport 
of dangerous goods – e.g. for skin and eye irritation, CMR or for the aquatic 
chronic hazards category 3 and 4. However, CLP labelling on the outer packaging 
is not obligatory in this case. 

Where the outer packaging does not need to carry labelling in accordance with 
the rules on the transport of dangerous goods (including transport labelling such 
as limited/exempted quantity marks) both the inner/intermediate and the outer 
packaging must be labelled according to the CLP requirements (Article 33(2)).  

The assumption underlying the abovementioned provisions has been that only 
one substance or mixture is contained in combined outer packaging.  

Where the outer packaging is transparent, all CLP label elements can be omitted 
from it where the CLP label beneath the transparent layer is clearly visible (Article 
33(2) of CLP).  

The legal requirements of CLP Article 33 and the decisions involved when dealing 
with them are depicted in the Figure 5. 

36 Directive 2008/68/EC for the inland transport of dangerous goods (road and rail). 

 
 
 
 
 
                                                 
45 

Single packaging 

No 

CLP label 

Transport 
label 
required? 

Yes 

Transport label 
and CLP label 

CLP pictograms 
covered by an 
equivalent 
transport 
pictogram may be 
omitted 

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Inner (and any 
intermediate) and 
outer packaging 

No 

Transport 
label 
required
? 

Yes 

Transparent  
outer  
packaging? 

Yes 

No 

CLP label on 
inner (and 
any 
intermediate) 
and outer 
packaging 

CLP label on 
inner (and any 
intermediate) 
packaging 

CLP label on 
outer packaging 
may be omitted 

Transport label on outer 
packaging; CLP label on 
inner (and any 
intermediate) 
packaging. 

The outer packaging 
may additionally be CLP 
labelled. If so, the CLP 
pictograms covered by 
an equivalent transport 
pictogram may be 
omitted. 

Figure 5: Decision flowchart for the application of CLP and transport labelling for 
single packaging (left) and combination packaging (right) 

 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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46 

6. Example labels 

In this section, 11 examples are provided to illustrate different situations that 
may be encountered when designing labels.  

Please note that each of the labels below serves only as an example of how to 
arrange the elements on the label in a given situation. The arrangements shown 
are not exhaustive or mandatory in all aspects. The dimensions of labels and label 
elements shown below are not necessarily the actual dimensions.  

Example 1: Single language label for a substance (not for the 
general public) 

This example represents a simple label for a substance for supply and use which 
takes into account the CLP label elements only. It shows the CLP terminology and 
pictograms in accordance with CLP Article 17(a) and (c) to (g), i.e. the product 
identifiers, the identity of the supplier, the signal word, the hazard pictograms, 
the hazard and the precautionary statements. As the substance is not supplied to 
the general public, the nominal quantity of the substance contained in the 
package is not required on the label. 

Hazard pictograms 

Product identifiers 

Supplier identity 

Signal word 

Highly flammable liquid and vapour. May be fatal if swallowed and 
enters airways. Causes skin irritation. May cause drowsiness or 
dizziness. Very toxic to aquatic life with long lasting effects. 

Keep away from heat, hot surfaces, sparks, open flames and other 
ignition sources. No smoking. Keep container tightly closed. Store in a 
well-ventilated place. Avoid breathing mist/vapours.  
Wear protective gloves and eye and face protection.  
IF INHALED: Remove person to fresh air and keep comfortable for 
breathing. Avoid release to the environment.  

Hazard statements 

Precautionary 
statements 

 
 
 
 
 
 
 
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Considering the industrial/professional use the combined statement P301 + P310 
has been omitted from the label. To further reduce the number of the P-
statements and the amount of digestible information on the label, the statements 
P391 has also been omitted from the label, as the prevention statements for the 
physical and health hazards appear to contain the more urgent advice for the 
label. The final selection of the P-statements resulted in a 6 P-statements 
compared to the starting set of 8 P-statements. 

All the P-statements (including the P-statements de-selected from the label) 
would have to be included in the SDS, under heading 2.2 (“Label elements”) to 
provide the industrial or professional user with sufficient information to handle the 
substance safely. 

Example 2: Multi-language label of a substance containing 
non-obligatory supplemental information (not for the 
general public) 

The example label given below represents a multi-language label for supply and 
use. It shows the CLP terminology and pictograms in accordance with CLP Article 
17(a) and (c) to (h), i.e. the product identifier, the identity of the supplier, the 
hazard pictograms, the signal words and the hazard and precautionary 
statements in four languages.  

As the substance is not supplied to the general public, the nominal quantity of the 
substance contained in the package is not required on the label.  

In accordance with CLP Article 32(3), the hazard and precautionary statements of 
one language are located together on the label. A section for supplemental 
labelling is included on the left-hand side of the label including non-obligatory 
supplemental labelling information. 

As to the lay-out, the label is an authentic label designed for a 2.5 litre bottle. 
Given that the real dimensions are slightly larger than depicted here, there is still 
potential to optimise the structuring of the information, e.g. by using a more 
prominent place for the signal word or larger letters for H- and P-statements. 
Based on the minimum dimensions for the label area, which would be at least 52 
mm x 74 mm, the size of each of the pictograms is supposed to be at least 257 
mm2, corresponding to a side length of 16 mm, on the real  label (sub-section 5.2 
of this guidance). 

If the section for supplemental labelling is increased (for example to incorporate 
information related to the use of the substance), the overall area of the label and 
the size of its elements may have to be increased as well, in particular the letter 
size of the signal words, hazard and precautionary statements. Such an increase 
would warrant the legibility of the obligatory label information which appears in 
multiple languages. In this case it may be wise also to increase the size of the 
pictograms.  

 
 
 
 
 
 
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Hazard & 
precautionary 
statements, 
grouped by 
language 

Supplier identity 

Section for 
supplemental 
labelling 
information  
(non-obligatory) 

Signal word 

Hazard 
pictograms 

Product identifiers 

 
 
 
 
 
 
 
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Example 3: Single language label of a mixture containing 
both obligatory and non-obligatory supplemental information 
(supplied to the general public) 

The example label given below illustrates the supply and use label for a typical 
consumer product (detergent).  

All obligatory labelling information is shown, i.e. the product identifiers (trade 
name and designation of the mixture; one of them would have been sufficient), 
the identity of the supplier, the signal word, the hazard and precautionary 
statements and the obligatory supplemental information, in accordance with 
Regulation (EC) No 648/2004 on detergents. Please note that supplemental label 
information according to CLP is grouped together whilst the other supplemental 
information (in this case the bar code) is located in another place. 

No P-statement on disposal is given as this is not required for a mixture classified 
as eye irritant. 

As the product is supplied to the general public, its nominal quantity is also 
provided on the label. Beyond the obligatory supplemental information, also some 
non-obligatory supplemental information is shown. 

This label clearly separates the obligatory information as required by CLP and 
other Community legislation from the non-obligatory elements. The former is 
delineated by two text boxes, with the “CLP box” being located in a central, eye-
catching position on the label. The non-obligatory label elements can be found in 
the lower part of the label and in the upper part, under the headline “instructions 
for use”.  

The label as depicted here has a real size of 165 mm x 72 mm; the area of the 
label that contains the obligatory label elements, i.e. the two boxes and the 
nominal quantity, is about 98 mm x 72 mm. In principle the area covered by the 
text block “For further information visit …” must be subtracted; on the other 
hand, approximately the same area covered by the line “trade name” should be 
added, so there is overall no change. 

The label is larger than the minimum dimensions required by CLP, which is at 
least 52 mm x 74 mm for a 500 ml bottle. The pictogram is larger than the 
required minimum area of 1 cm2. 

The label shown is primarily drafted for inner packaging. If the chemical is 
contained in combination (= inner + outer) packaging, the same information has 
to be shown on the outer packaging, unless the information on the inner 
packaging can be seen through the outer packaging.  

 
 
 
 
 
 
 
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Hazard pictogram 

Supplier identity 

Product identifiers  

(trade  name  and  designation 
of the mixture) 

Non-obligatory supplemental 
information  
(here: identified uses) 

Obligatory supplemental 
information 

Product identifier  
(designation of the mixture) 

Signal word 

Hazard statement 

Precautionary statements 

Nominal quantity 

Non-obligatory supplemental 
information 

 
 
 
 
 
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Example 4: Single language label for a substance containing 
supplemental hazard statements (not for the general public) 

The example below illustrates a label for lithium (EC No 231-102-5) for supply 
and use. A harmonised classification (Water-react. cat. 1, Skin corr. cat. 1B) as 
well as the supplemental hazard statement EUH014 are assigned through Annex 
VI to CLP. No other available, reliable information was found that identified any 
further hazards. The substance is not intended to be used by the general public; 
it is supplied in a 1 litre package. 

All obligatory labelling information is shown, i.e. the product identifiers, the 
identity of the supplier, the hazard pictograms, the signal word, the hazard and 
precautionary statements and the supplemental hazard statement EUH014, in 
accordance with Table 3.1 of Annex VI to CLP. Although EUH014 is supposed to 
be supplemental information only, it is intentionally placed close to the regular 
CLP hazard statements to reinforce the message provided by the latter. 

Product identifiers 

Hazard pictograms 

Signal word 

Lithium 

EC No 231-102-5 

Danger 
Reacts violently with water. 

In contact with water releases 
flammable gases which may ignite 
spontaneously.  

Causes severe skin burns and eye 
damage. 

Hazard 
statements 

Supplemental 
hazard statement 
EUH014 

Wear protective gloves / protective clothing / eye protection/face protection.  
Brush off loose particles from skin. Immerse in cool water. IF SWALLOWED: Rinse mouth. 
Do NOT induce vomiting. Immediately call a POISON Center/doctor. IF ON SKIN (or hair): 
Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: 
Rinse cautiously with water for several minutes. Remove contact lenses, if present and 
easy to do. Continue rinsing.  

Precautionary 
statements 

Company X, Street Y, CITY ABC,  
phone number: +49 (0) 0000 00 00 00. 

Supplier identity 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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Example 5: Multi-language label for a mixture containing 
both obligatory and non-obligatory supplemental information 
(supplied to the general public)  

Example 5 represents a draft multi-language label for a typical consumer 
chemical (decorative paint) for supply and use.  

All obligatory labelling information is shown, i.e. the product identifiers, the 
identity of the supplier, the signal word, the hazard and precautionary statements 
and the obligatory supplemental information, in particular information in 
accordance with Directive 2004/42/EC on the limitation of emissions of volatile 
organic compounds (VOC) due to the use of organic solvents in certain paints and 
varnishes and vehicle refinishing products.  

In accordance with CLP Article 32(3), the hazard and precautionary statements of 
one language are located together on the label. As the chemical is supplied to the 
general public, its nominal quantity is also provided on the label. Beyond the 
obligatory label elements, non-obligatory supplemental information is shown.  

This example label separates the CLP label elements from the supplemental 
information. The CLP label elements are located in a more eye-catching position 
on the label while the supplemental information can be found rather in the 
margins of the label. The texts reflecting the supplemental information appear in 
slightly smaller letters than the CLP label elements. 

The size of this label is intended to be 125 mm x 150 mm when applied on the 
packaging. This means that the real label will be considerably larger than the 
minimum label size for a 1 litre package (52 x 74 mm) required under CLP. The 
pictogram size of 19 x 19 mm is less than 1/15th of the area of the whole label, 
but greater than 1/15th of the area dedicated to the information required by 
Article 17.

 
 
 
 
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Product identifier 

Hazard pictogram 

Non-obligatory supplemental 
information 

Signal word 

Supplier 
identity 

Signal word, 
hazard and 
precautionary 
statements in 
three 
languages 

Obligatory supplemental 
information according to the 
VOC Directive 

Non-obligatory supplemental 
information 

Nominal quantity 

 
 
 
 
 
 
 
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Example 6: Fold-out label of a mixture (supplied to the 
general public)  

The example below represents a multilingual, fold-out label for a mixture for 
supply and use, intended for the general public.  

The label for this mixture is required to bear a large number of obligatory CLP 
label elements, namely three hazard pictograms, three hazard statements and 
numerous precautionary statements subject to the principles of precedence. It 
was impossible to put all these label elements on the immediate container due to 
its shape and size (plastic container of 100 ml capacity). Therefore, the supplier 
has decided to choose the fold-out label as a solution to address all the labelling 
problems encountered. The label elements are included on the label in the 
following way: 

Front page  

 

trade name or designation, 

  hazard pictograms, 

  signal words in all languages of the label, 

  nominal quantity, as the mixture is made available to the general public, 

  contact details of supplier, 

 

reference to the full safety information inside (in this case the front page 
contains the symbol of an arrow to illustrate that the full safety 
information is available on inside pages), 

  country codes indicating which languages are covered by the label 

Inside pages 

 

full product identifier (including hazardous compounds A, B and C in this 
particular case), 

  signal word, 

  hazard statements, 

  precautionary statements, 

The full safety information on the inside pages is given in each language 
mentioned on the front page and also grouped by language. The country 
codes are featured on the top of each inner page to enable the user to quickly 
identify his language. 

Back page (attached to the immediate container) 

 

trade name or designation, 

  hazard pictograms, 

  signal word, 

  nominal quantity,  

  contact details of supplier. 

 
 
 
 
 
 
 
 
 
55 

Trade name 

Signal  
word in all 
languages 
of the label  

Hazard 
pictograms 

Supplier 
identity 
1 

Back page firmly 
affixed to  
the immediate 
container 

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Product identifier 
including three 
hazardous components 
that contribute to the 
classification of the 
mixture 

Signal  
word 

Inside  
pages 

Language  
code 

Front page  
wrapped around  
the container 

Hazard 
statements 

Nominal 
quantity 

Precautionary 
statements 

Language  
codes 
indicating 
languages 
covered by the 
label 

Symbol informing  
the user that the label 
can be  
opened and  
indicating that the 
additional information 
is available on inside 
pages 

 
 
 
 
 
 
 
 
 
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6.1 Packaging that is small or difficult to label 

The example labels in this sub-section are authentic; they are applied on inner 
packaging only because the package is transported in larger consignments with 
specific outside labelling in accordance with the rules on the transport of 
dangerous goods. Please note that the labelling exemptions only apply if the 
alternative labelling on fold-out labels, tie-on tags or outer packaging is 
technically not feasible. 

Example 7: n-Hexane in a 8 ml bottle (not for the general 
public) 

The example given below represents a two-language label in Finnish and Swedish 
for small packaging for the substance n-hexane. Both languages are required in 
Finland. According to Annex VI to CLP, the substance is assigned the following 
classifications:  

Flam. Liq. 2  

H225 Highly flammable liquid and vapour 

Repr. 2  

H361 Suspected of damaging fertility or the unborn child 
(state specific effect if known) (state route of exposure if it 
is conclusively proven that no other routes of exposure 
cause the hazard)) 

Asp. Tox. 1  

H304 May be fatal if swallowed and enters airways 

STOT-RE 2  

H373 May cause damage to organs (state all organs 
affected, if known) through prolonged or repeated exposure 
(state route of exposure if it is conclusively proven that no 
other routes of exposure cause the hazard) 

Skin Irrit. 2   

H315 Causes skin irritation 

STOT SE 3            H336 May cause drowsiness or dizziness 

Aquatic Chronic 2   H411 Toxic to aquatic life with long lasting effects 

Based on CLP Article 17, many labelling elements would be required. The bottle 
containing the substance is placed on the market individually. Since it is assumed 
for this example that the labelling information cannot be accommodated on a 
fold-out label, tie-on tag or on outer packaging, the supplier is allowed to apply 
the small packaging exemptions outlined in section 1.5.2 of Annex I to CLP.  

Accordingly, the hazard and precautionary statements pertaining to the following 
hazard classes and categories: 

Flam. Liq. 2, STOT-RE 2, Skin Irrit. 2, STOT-SE 3 and Aquatic Chronic 2  

may be omitted from the label. However, and in line with CLP, the hazard 
pictograms: GHS02, GHS07, GHS08 and GHS09 were retained for these hazards.  

No small packaging exemptions apply to the following hazards classes and 
categories: Repr.2 and Asp. Tox. 1. This means that the pictograms and the 

 
 
 
 
 
 
 
 
 
 
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hazard and precautionary statements pertaining to these hazard classes and 
categories have been retained. 

The precautionary statements have obviously been reduced, following CLP Article 
22 and 28. For example, the statement P501 (Dispose of contents/container to …) 
was not included because the substance is neither supplied to the general public 
nor are there specific disposal requirements above the normal expectation for the 
disposal of chemicals (see also section 7 of this guidance). Out of a set of 
originally 20 different precautionary statements, finally only one single 
(combination) statement, namely P301+P310+P331 (IF SWALLOWED: 
Immediately call a POISON CENTRE/doctor. Do NOT induce vomiting.) remains on 
the label. In accordance with CLP Article 32(3), the hazard statements of one 
language as well as the precautionary statements, respectively, are located 
together on the label. Finally, the signal word “Danger” (Finnish: Vaara; Swedish: 
Fara) was selected, in line with the applicable precedence rule. 

No omissions, but full 
range of hazard 
pictograms 

Small packaging exemptions: 
reduced set of hazard and 
precautionary statements, grouped 
together on the label by language. 

If the real dimensions of the label are 32 x 95 mm it can accommodate four 
pictograms of the required minimum size of 1 cm2. This may not always be 
possible for even smaller packaging volumes, e.g. a bottle volume of 4 ml, see 
below. In order to maintain the required minimum size of 1 cm2 for the hazard 
pictograms in such cases, either the size of the label or the volume of the bottle 
as such will have to be increased. It may not be warranted to reduce the letter 
size of the texts as this will very probably decrease their legibility. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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Due  to  space  constraints  on  small  volume 
packaging,  pictograms  of  the  required 
minimum  size  of  1  cm2  cannot  always  be 
accommodated. In this case either the size 
of the label or the volume of the bottle will 
have to be increased. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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Example 8: Hazardous solid substance in a 100 ml bottle (not 
intended for the general public) 

This example represents a one-language label for small packaging for a solid 
substance Y which is assigned the following classifications:  

Ox. Sol. 2  

Carc. 1B  

Muta 1B 

Repr. 1B  

H272 May intensify fire; oxidiser 

H350 May cause cancer (state route of exposure if it 
is conclusively proven that no other routes of 
exposure cause the hazard) 

H340 May cause genetic defects (state route of 
exposure if it is conclusively proven that no other 
routes of exposure cause the hazard) 

H360 May damage fertility or the unborn child (state 
specific effect if known) (state route of exposure if it 
is conclusively proven that no other routes of 
exposure cause the hazard) 

Acute Tox. 2 (inhalation) 

H330 Fatal if inhaled 

Acute Tox. 3 (oral) 

H301 Toxic if swallowed 

STOT RE 1  

H372 Causes damage to organs (state all organs 
affected, if known) through prolonged or repeated 
exposure (state route of exposure if it is conclusively 
proven that no other routes of exposure cause the 
hazard) 

Acute Tox. 4 (dermal)  

H312 Harmful in contact with skin 

Skin Corr. 1B  

Resp. sens. 1  

Skin sens. 1  

Aquatic Acute 1  

Aquatic Chronic 1 

H314 Causes severe skin burns and eye damage 

H334 May cause allergy or asthma symptoms or 
breathing difficulties if inhaled 

H317 May cause an allergic skin reaction 

H400 Very toxic to aquatic life 

 H410 Very toxic to aquatic life with long lasting 
effects 

Pursuant to CLP Article 17, a lot of labelling information would be required. 
Similarly to the previous example, it is assumed that the supplier is allowed to 
use the small packaging exemptions outlined in section 1.5.2 of Annex I to CLP. 

Substance Y is not presumed to be listed in Annex VI to CLP, nor in the 
Classification and Labelling Inventory. Therefore, only the product identifiers 
referred to in CLP Article 18(2)(c) need to be provided, i.e. the CAS number (if 
available, see CLP Article 18(2)(d)) and the IUPAC or another international name.  

In accordance with the small packaging exemptions outlined in section 1.5.2 of 
Annex I to CLP, only the hazard and precautionary statements pertaining to the 
following hazard classes and categories:  

Ox. Sol. 2, Acute Tox. 4, Aquatic Acute 1, and Aquatic Chronic 1  

 
 
 
 
 
 
 
 
 
 
 
 
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may be omitted from the label. This means that for all the other hazards listed 
above all the label elements that are required under CLP Title II have to appear 
on the label. 

The precautionary statements on the example label below start with “Obtain 
special instructions before use.” A significant reduction has been performed for 
the precautionary statements, based on Articles 22 and 28 of CLP. After 
application of the small packaging exemptions and the selection of the most 
appropriate set of precautionary statements, only five (combined) statements 
were chosen for the label, out of about 30 precautionary statements.  

In addition to the hazard and precautionary statements, five different hazard 
pictograms are required for the label, namely GHS03, GHS05, GHS06, GHS08 and 
GHS09. 

Due  to  the  severity  of  the  hazards,  substantial 
reduction  of  the  hazard  statements  is  not  possible.  
The  number  of  the  precautionary  statements  however, 
has been substantially reduced. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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Example 9: Supply and transport label for a single package 
(not intended for the general public) 

This example illustrates the provisions of CLP Article 33(3) and represents a label 
for a hazardous mixture which is assigned the following classifications:  

Flam. Liq. 2    

H225 Highly flammable liquid and vapour 

Acute Tox. (dermal) 3  

H311 Toxic in contact with skin 

Skin irrit. 2  

STOT SE 3  

STOT SE 3  

STOT RE 2   

H315 Causes skin irritation 

H335 May cause respiratory irritation 

H336May cause drowsiness or dizziness 

H373 May cause damage to organs (state all organs 
affected, if known) through prolonged or repeated 
exposure (state route of exposure if it is conclusively 
proven that no other routes of exposure cause the 
hazard) 

Asp. Tox. 1  

H304 May be fatal if swallowed and enters airways 

Aquatic Acute 1  

H400 Very toxic to aquatic life 

Aquatic Chronic 1  

H410 Very toxic to aquatic life with long lasting 
effects  

The mixture is intended to be supplied in single packaging, such as a 200 litre 
drum. This means that both the CLP and the transport label elements must be 
shown on the packaging. The mixture is not intended to be used by the general 
public. 

In this case the supplier has chosen to include the transport label elements and 
marks together with the CLP labelling elements on a joint label. This common 
label would be large enough to conform to the specifications set out in ADR (e.g. 
minimum dimensions of 100mm x 100mm).  

In relation to the CLP hazard pictograms GHS06 and GHS07, only GHS06 needs 
to be displayed, in accordance with the precedence rule set out in CLP Article 
26(1)(b). However, the supplier has omitted the CLP hazard pictograms GHS06 
and GHS02, as the underlying hazard classes and categories are already covered 
by the corresponding transport pictograms.  

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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Product identifier 

CLP hazard pictogram 

Transport labelling 

Product identifier 
including  
substances that 
contribute to the 
classification of 
the mixture as 
acutely toxic, 
STOT-RE and toxic 
by aspiration 

TOXIFLAM      
(Contains X, Y) 

Signal word 

Hazard 
statements 

Precautionary 
statements 

Space for  
further 
supplemental 
information  
(e.g. 
instructions 
for use) 

Danger  
Highly flammable liquid and vapour.  
Toxic in contact with skin.  
Causes skin irritation.  
May cause respiratory irritation.  
May cause damage to liver, testis through 
prolonged or repeated exposure.  
May be fatal if swallowed and enters airways.  
Very toxic to aquatic life with long lasting effects.  
May cause drowsiness or dizziness. 

Keep away from heat, hot surfaces, sparks,  
open flames and other ignition sources.  
No smoking. Wear protective gloves and clothing  
and eye protection. IF SWALLOWED: Immediately  
call a POISON CENTER/doctor. Do NOT induce vomiting.  
Avoid release to the environment.  
Dispose of container to the municipal collection point. 

See safety data sheet for further details regarding safe use. 

Supplier Identity 

Manufactured by 

Company X,  
Street Y,  
Town Z 
Code 00000,  
Tel: +49(0)0000000000. 

UNXXXX 

[Proper Shipping Name] 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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Example 10: Labelling of a mixture that is transported on 
land in outer and inner packaging (not intended for the 
general public) 

This example illustrates the provisions of CLP Article 33(2). It is an example of a 
mixture which is classified and labelled under CLP, but not according to the rules 
on the transport of dangerous goods. The mixture is transported on land and is 
contained in an inner packaging (cans) which is itself contained in outer 
packaging (box) which is not transparent. This means that the same labelling 
information has to be provided both on the inner packaging and on the outer 
packaging. The mixture is not intended to be used by the general public. 

Inner packaging 

CLP hazard 
pictogram 

Product identifier 

Signal word 

Thinner X 

H-statement 

Warning 

P-statements 

Outer packaging 

Causes skin irritation 

Thinner X 

Warning 

Causes skin irritation. 

Wear protective gloves/protective clothing/eye 
protection/face protection. Wash hands thoroughly after 
handling.  

IF ON SKIN: Wash with plenty of water. If skin irritation 
occurs: Get medical advice/attention. Take off 
contaminated clothing and wash it before reuse. 

Company X, Street Y, Town Z,  
Code 00000,  
Tel: +49(0)0000000000. 

Wear protective gloves/protective clothing/eye 
protection/face protection. Wash hands 
thoroughly after handling. IF ON SKIN: Wash 
with plenty of water. If skin irritation occurs: Get 
medical advice/attention. Take off contaminated 
clothing and wash it before reuse. 

Company X, Street Y, Town Z 
Code 00000,  
Tel: +49(0)0000000000. 

Supplier identity 

CLP label required on outside of box 
because the hazard is not covered by 
transport rules and the outer packaging 
is not transparent 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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Example 11: Labelling of a mixture that is transported on 
land in single packaging (not intended for the general public) 

This example illustrates the provisions related to the labelling of single packaging 
in accordance with CLP Article 33(3). It is an example of a chemical that is 
classified and labelled in accordance with the rules on the transport of dangerous 
goods and under CLP. The chemical is transported on land in single packaging 
(can). It is not intended to be used by the general public. 

In this example the full CLP labelling information is provided by means of a 
separate label, in addition to the transport labelling information (version 1). 

The CLP hazard pictogram GHS09 may be omitted from the packaging because it 
relates to the same hazards as the “dead tree – dead fish” transport mark 
(version 2). 

Version 1: 

Single packaging with transport 
labelling … 

… and the CLP labelling 
information 

U 

N 

1A2/Y1.2/100/08/NL/TDV441 

Environmentally hazardous 
substance, liquid, N.O.S.  
(contains X, Y)  

Paint Z 
(Contains X, Y,) 

Warning 

UN 3082 

Very toxic to aquatic life with long lasting effects 

Avoid  release  to  the  environment.  Collect  spillage. 
Dispose of contents/container to local waste disposal 
company. 

VOC  content:  EU  limit  for  this  product  is  (cat.  A/d): 
300 g/l. This product contains max 299 g/l VOC. 

Company X, Street Y, Town Z,  
Code 00000,  
Tel: +49(0)0000000000 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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Single packaging with the 
transport labelling … 

… and the CLP labelling information 
without the CLP pictogram GHS09 
for the aquatic hazards 

U 

N  

1A2/Y1.2/100/08/NL/TDV
441 

Environmentally hazardous 
substance, liquid, N.O.S.  
(contains X, Y)  

UN 3082 

Paint Z 

(Contains X, Y) 

Warning 

Very  toxic  to  aquatic  life  with  long  lasting 
effects 

Avoid release to the environment. Collect spillage. 
Dispose  of  contents/container 
local  waste 
disposal company. 

to 

VOC content: EU limit for this product is (cat. A/d): 
300 g/l. This product contains max 299 g/l VOC. 

Company X, Street Y, Town Z,  
Code 00000,  
Tel: +49(0)0000000000 

 
 
 
 
 
 
 
 
 
 
 
 
 
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6.2 Specific case: labelling of two-component products 

In certain specific cases the packaging of the product can be so unique that it is 
difficult to meet the CLP labelling requirements. An example of such a situation 
has been given below. Please note that the example only illustrates the general 
aspects of labelling of two component products and is not intended to present the 
correct selection of appropriate label elements. 

Picture 1. Two-component adhesive sold as a kit (below) shows an example 
of a popular two-component adhesive consisting of two mixtures, namely an 
epoxy resin (Part A) and a hardener (Part B). The two mixtures are placed in 
separate containers which are fixed together and sold as a kit in transparent 
outer packaging. When used, the content of both containers is mixed by 
extrusion. Part A and Part B react to produce a final mixture which can be used as 
an adhesive for a wide range of materials.  

In this type of situation two separate labels need to be affixed to the containers 
(one label for each mixture (in a container)). The hazard information provided on 
the labels must relate to the form/physical states in which both mixtures (Part A 
and Part B) are placed on the market. The outer packaging of the whole kit need 
not be labelled, as it is transparent and permits the inner packaging (both 
containers) to be clearly seen.  

If the product formed during end-use is hazardous (with different properties to 
the mixtures in the containers), sufficient instructions to enable safe use must be 
provided to the user. The instructions can for example be provided on the label or 
as a separate leaflet in the package. 

If such a product is not intended for the general public, two separate safety data 
sheets should be provided to enable the users to meet their responsibilities in 
relation to the management of risks arising from the use of the reaction product 
that occur upon the end use of the two mixtures (i.e. the adhesive).  
As the adhesive in the example is also classified as hazardous, the relevant 
information about the risk management measures should be provided in the 
SDSs.  

Please note: a case-by-case judgement may be necessary when determining the 
labelling requirements for similar, unique packagings. The information should not 
confuse the user and the label should be easily understandable. 

 
 
 
 
 
 
 
 
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7. Guidance on the selection of precautionary 
statements for the CLP hazard label 

7.1 Introduction 

Based on the UN GHS, the CLP Regulation assigns precautionary statements to all 
hazard classes for the purpose of the safe supply and use of a substance or 
mixture. Based on CLP Article 4, suppliers have to select precautionary 
statements for the CLP hazard label. Suppliers can be the following:  

importers of mixtures; 

  manufacturers or importers of substances,  
 
  downstream users of substances or mixtures (including formulators),  
  distributors (including retailers) of substances or mixtures, and 
  producers or importers of explosive articles as defined in Part 2.1 of Annex 

I to CLP. 

The selection of precautionary statements must be done based on CLP Articles 22 
and 28 and CLP Annex IV: 

Article 22 

Precautionary statements 

1.  The label shall include the relevant precautionary statements. 

2.  The precautionary statements shall be selected from those set out in the tables in 

Parts 2 to 5 of Annex I indicating the label elements for each hazard class. 

3.  The precautionary statements shall be selected in accordance with the criteria laid 
down  in  Part  1  of  Annex  IV  taking  into  account  the  hazard  statements  and  the 
intended or identified use or uses of the substance or the mixture. 

4.  The precautionary statements shall be worded in accordance with Part 2 of Annex 

IV. 

Article 28 

Principles of precedence for precautionary statements 

1.  Where  the  selection  of  the  precautionary  statements  results  in  certain 
precautionary  statements  being  clearly  redundant  or  unnecessary  given  the 
specific substance, mixture or packaging, such statements shall be omitted from 
the label. 

2.  Where  the  substance  or  mixture  is  supplied  to  the  general  public,  one 
precautionary statement addressing the disposal of that substance or mixture as 
well  as  the  disposal  of  packaging  shall  appear  on  the  label,  unless  not  required 
under  Article  22.  In  all  other  cases,  a  precautionary  statement  addressing 
disposal shall not be required, where it is clear that the disposal of the substance 
or  mixture  or  the  packaging  does  not  present  a  hazard  to  human  health  or  the 
environment. 

3.  Not  more  than  six  precautionary  statements  shall  appear  on  the  label,  unless 

necessary to reflect the nature and the severity of the hazards. 

“In  selecting  the  precautionary  statements  in  accordance  with  Articles  22  and  28(3), 
suppliers may combine the precautionary statements in the tables [of Annex IV], having 
regard to clarity and comprehensibility of the precautionary advice. (…).” 

Annex IV 

 
 
 
 
 
 
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Neither the UN GHS nor the CLP Regulation provide for clear-cut rules on how to 
select precautionary statements for the label (apart from the provisions of Articles 
22 and 28 and the basic instructions given in the columns specifying the 
conditions for use in tables 6.1-6.5 of Annex IV to CLP).  

On the other hand, the number of precautionary statements under CLP/GHS has 
more than doubled when compared to the number of S-phrases under DSD. In a 
situation where selection rules are missing, an average hazardous substance 
listed in Annex VI to CLP could easily be assigned more than 20 precautionary 
statements on the label, based on the hazards of the substance (sub-section 3.4 
of this guidance). CLP requires that normally37 not more than six precautionary 
statements must appear on the label. Therefore, a substantial reduction of the 
number of precautionary statements must be performed, based on effective 
selection rules. 

7.2 Methodology 

The selection of precautionary statements under CLP is based on:  

– 

– 

– 

the provisions set out in CLP Articles 22 and 28 and  

the basic instructions provided in the columns containing the conditions for 
use in tables 6.1-6.5 of Annex IV to CLP and  

the instructions mentioned directly under the precautionary statements in 
the selection tables (sub-section 7.3 of this guidance).  

The following approach was chosen for the selection of the precautionary 
statements under CLP: 

  The P-statements38 should be selected in accordance with the rules 

outlined in Article 28 and Part 1 of Annex IV;  

  The selection of P-statements should take into account the underlying 
hazards and identified or foreseen conditions for use of a substance or 
mixture; 

  The P-statements assignment follows a “traffic light” system. The 
conditions for use described in this guidance document distinguish 
between precautionary statements that are “highly recommended”, 
“recommended”, “optional” and “not to be used” for the hazard label; 

  A particular recommendation should be seen in the light of the original CLP 

conditions for use specified under the relevant precautionary statement in 
the selection tables: 

  Unlike DSD, the CLP includes one mandatory precautionary statement 

relating to disposal, namely P501 (Dispose of contents/container to …) for 
substances or mixtures supplied for the general public;  

  Two target groups: the general public and the industrial/professional users 
are specified under CLP. Where there is no explicit mention of the target 

37 Unless necessary to reflect the nature and the severity of the hazards. 

38  Corresponding but not always identical  to the former  safety phrases  (S-phrases)  under 
DSD. 

 
 
 
 
 
 
                                                 
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group, the conditions for use apply to both the general public and 
industrial/professional users. 

  Where the use of a particular precautionary statement is (highly) 

recommended but some exemptions are indicated (“unless” condition), it 
should not be used where the conditions specified in the “unless” clause 
apply:  

For example:  
P264 (Wash … thoroughly after handling) for the hazard class: Skin 
corrosion 1 should not be used for industrial/professional users where 
P280 (Wear protective gloves/protective clothing/eye protection/face 
protection) has already been selected for the hazard label of the substance 
or mixture.  

Vice versa, where a precautionary statement is only optional, it should be 
used where the conditions specified in the “unless” clause apply: 

For example:  
P410 (Protect from sunlight) for the hazard class: Gases under pressure 
should be applied in case the described gases are subject to (slow) 
decomposition or polymerisation 

  Similarly to the previous bullet point: where the use of a particular 

precautionary statement is (highly) recommended under certain conditions  
only, it should not be used where these conditions do not apply:  

For example:  
P260 (Do not breathe dust/fume/gas/mist/vapours/spray) should not be 
used where a skin corrosive substance is not highly volatile. 

  For some hazards the use of many specific precautionary statements will 
normally have to be recommended. As a consequence, the number of 
precautionary statements on the label will easily exceed the target number 
of six even for simple substances.  

On the other hand, the label, as compared to the SDS, is not always the 
only and most appropriate means to convey a message to 
industrial/professional users, e.g. for P241 (Use explosion-proof 
electrical/ventilating/lighting/ …/equipment.). In such cases the guidance 
also refers to the SDS, typically by phrasing both a recommendation for 
the label and for the SDS. The recommendation for inclusion on the label 
is then “weaker” than for the SDS, see for example P241 for flammable 
liquids or P373 (DO NOT fight fire when fire reaches explosives) for 
explosive hazards. In some cases it is even recommended to put the 
relevant precautionary statements in the SDS only;   

 

In relation to the physical hazards, it should always be determined 
whether substances or mixtures displaying these hazards are supplied to 
or handled by the general public. Where this is not the case, the use of 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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further precautionary statements could be de-prioritised (“weaker” 
recommendation); 

  Where the substance or mixture is supplied to the general public one P-

statement relating to disposal of that substance/mixture or the disposal of 
the packaging must appear on the label unless not required under Article 
22. In all other cases the P-statement addressing disposal is not required 
if it is clear that the disposal of the substance or mixture or the packaging 
does not present a hazard to human health or the environment; 

  Where it is proposed to combine two or more precautionary statements 
that could also be used on their own, the conditions of use specify 
“(highly) recommended, in combination with Pxxx”: 

For example:  
“Highly recommended, in combination with P302 + P352 (IF ON SKIN: 
Wash with plenty of water/…)” for P310 (Immediately call a POISON 
CENTER/doctor/...) for the hazard class: Acute Tox. 1 and 2 (dermal). 

Such combined statements should be counted as one P-statement; 

  Additional guidance is provided for the application of the precautionary 

statements P101 (If medical advice is needed, have product container or 
label at hand), P102 (Keep out of reach of children) and P103 (Read label 
before use) for hazardous substances and mixtures supplied to the general 
public (see table in sub-section 7.3.1 of this guidance). 

It should be noted that for substances and mixtures which are at the same time 
classified for physical, health and environmental hazards, a selection based on 
the rules outlined in this CLP guidance may still lead to a final set that 
significantly exceeds the target number of six statements for the label (see 
Example C). Even if this can in principle be justified by CLP Article 28(3), the 
question remains whether the extent of the labelling information is still digestible, 
in particular where long combination statements appear.  

Therefore, when verifying the set of P-statements selected on the basis of this 
guidance, it is proposed to take into account the following principles: 

–  certain prevention and response statements provide more urgent advice 
than other statements, as rapid action may be crucial. Therefore, where 
similar P-statements having different priorities are assigned because of 
different hazards, the most stringent P-statement should be selected. This 
judgement can only be done on a case-by-case basis and will strongly 
depend on the hazards involved: 

For example:  

For substance classified as acutely toxic and carcinogenic, the first aid 
measures for acute toxicity will take precedence over the longer term 
effects, i.e. P310 (Immediately call a POISON CENTER/doctor/...) will 
take precedence over  P311 (Call a POISON CENTER/doctor/...), P312 
(Call a POISON CENTER/doctor/…/if you feel unwell) and P313 (Get 
medical advice/attention). 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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–  de-selecting statements which appear less urgent from the label and 

putting them in the SDS would be a better option; 

– 

to reduce the number of P-statements, the content of the hazard 
statement can also be taken into account: 

For example:  

Omission of P222 (Do not allow contact with air) for hazard classes: 
Pyrophoric liquids and Pyrophoric solids, the hazard statement being: 
H250 (Catches fire spontaneously if exposed to air). 

Where an SDS must be compiled, the precautionary statements selected for the 
CLP hazard label have to be included in the SDS, under heading 2.2 (“Label 
elements”), see the Guidance on the compilation of safety data sheets. The de-
selected statements can be introduced under the relevant headings of the SDS 
instead, to provide the industrial or professional user with sufficient information 
for handling the substance or mixture safely.  

7.3 Selection tables 

The below selection tables (sub-sections 7.3.1 to 7.3.5 of this guidance) follow 
the format as provided in Section 3 of Annex 3 to the UN GHS. The tables are 
arranged according to hazard class and category as appropriate.  

The guidance builds upon the generic provisions set out in CLP Article 22 and 28, 
as well as the basic instructions provided in the columns containing the conditions 
for use in tables 6.1-6.5 of Annex IV to CLP. It takes into account i.a. the 
intended uses and the physical properties of the substance or mixture.  

The original CLP conditions for use are displayed in black colour under the 
relevant precautionary statements in the selection tables below. In contrast, the 
conditions which constitute EU guidance are marked with an asterisk bullet  
and in blue colour, in order to distinguish them from the original CLP conditions 
for use (see also the columns containing the conditions for use in tables 6.1 – 6.5 
of Annex IV to the CLP Regulation). 

For some hazard classes/categories the assignment of precautionary statements 
and corresponding conditions for use is proposed although they are not assigned 
based on the CLP Regulation. This applies in most cases to self-reactive 
substances and mixtures and organic peroxides. The guiding principle for these 
additional assignments is that the same (response) precautionary statements 
should be applied to self-reactive substances and mixtures and organic peroxides.  

Where corresponding assignments and conditions for use are proposed, this is 
highlighted with the notion “add” after the code for the precautionary statement.  

When a forward slash “/” appears in a precautionary statement text, it indicates 
that a choice has to be made between phrases it separates: 

For example:  

P280 (Wear protective gloves/protective clothing/eye protection/face protection) 
could read: “Wear eye protection” or “Wear eye and face protection”. 

 
 
 
 
 
 
 
 
 
 
 
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When three full stops “…” appear in precautionary statement text, they indicate 
that all applicable conditions are not listed: 

For example:  

P241 (Use explosion-proof electrical/ventilating/lighting/…/equipment). The use 
of “…” indicates that other equipment may need to be specified by manufacturer 
or supplier. 

In selecting the precautionary statements in accordance with the conditions for 
use set out in the tables, suppliers may combine these statements, having regard 
to clarity and comprehensibility of the precautionary advice. In this case the 
specific wording of the component phrases must be retained in the combined 
phrases. The selection tables are followed by four examples (A, B, C and D) of 
substances where the selection of precautionary statements for the label is 
illustrated. 

7.3.1 General precautionary statements 

Precautionary Statement 

P101 

If medical advice is needed, have product container or label at hand. 

- Consumer products 

  Highly recommended for all substances and mixtures classified for health hazards and that are sold 

to the general public 

P102 

Keep out of reach of children. 

- Consumer products 

  Highly recommended for substances and mixtures sold to the general public, except for those only 

classified as hazardous to the environment 

  Applies also to packagings that are to be fitted with child resistant fastening (Annex II, section 

3.1.1.1) 

P103 

Read label before use. 

- Consumer products 

  Optional, but may be required by other EU legislation 

 
 
 
 
 
 
 
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73 

7.3.2 Specific precautionary statements for physical hazards  

7.3.2.1 Explosives  

Hazard category 

Signal word   

Hazard statement 

Unstable explosive 

Danger 

H200  Unstable explosive 

Precautionary Statements 

Prevention 

P201 

Obtain special instructions before 
use. 

  Highly recommended 

P202 

Do not handle until all safety 
precautions have been read and 
understood. 

  Optional where P201 has already 

been assigned 

P280 

Wear protective 
gloves/protective clothing/eye 
protection/face protection. 

Manufacturer/supplier to specify type 
of equipment. 

- Specify face protection. 

Response 

P372 

Storage 

P401 

Disposal 

P501 

Explosion risk in case of fire. 

Store … 

… in accordance with 
local/regional/national/international 
regulations (to be specified). 

  Highly recommended for 

inclusion in the safety data 
sheet. Specify the applicable 
regulation.  

  Highly recommended 

P373 

DO NOT fight fire when fire 
reaches explosives. 

  Recommended 

  Highly recommended for inclusion 

in the safety data sheet 

P380 

Evacuate area. 

  Highly recommended, in 

combination with P372 

Dispose of 
contents/container to … 

… in accordance with local/ 
regional/national/international 
regulations (to be specified). 

  Recommended for inclusion 

in the safety data sheet if 
there are specific disposal 
requirements above the 
normal expectation for the 
disposal of chemicals. Specify 
the applicable regulation. 

 
 
 
 
 
 
 
 
 
 
 
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  Highly recommended to apply the 

full wording of P280 

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7.3.2.1 Explosives  

Hazard category 

Signal word   

Hazard statement 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Division 1.1 

Division 1.2 

Division 1.3 

Danger 

Danger 

Danger 

Precautionary Statements 

Prevention 

P210 

Keep away from heat, hot surfaces, 
sparks, open flames and other 
ignition sources. No smoking. 

H201  Explosive; mass explosion hazard 

H202  Explosive; severe projection hazard  

H203  Explosive; fire, blast or projection hazard 

Response 

P370 + P380 

Storage 

P401 

In case of fire: Evacuate area. 

Store … 

  Highly recommended 

… in accordance with 
local/regional/national/internationa
l regulations (to be specified). 

  Highly recommended  

P372 

P230 

Keep wetted with … 

… Manufacturer/supplier to specify 
appropriate material. 

- if drying out increases explosion 
hazard, except as needed for 
manufacturing or operating processes 
(e.g. nitrocellulose). 

  Highly recommended for substances 
and mixtures which are wetted, 
diluted, dissolved or suspended 
with a phlegmatiser in order to 
reduce or suppress their explosive 
properties (desensitized 
explosives). The appropriate 

Explosion risk in case of fire. 

  Highly recommended for 

inclusion in the safety data 
sheet. Specify the applicable 
regulation.  

  Highly recommended, in 

combination with P370+P380: 
Explosion risk in case of fire: 
Evacuate area 

P373 

DO NOT fight fire when fire 
reaches explosives. 

  Recommended 

  Highly recommended for inclusion 

in the safety data sheet 

Disposal 

P501 

Dispose of 
contents/container to … 

… in accordance with local/ 
regional/national/international 
regulations (to be specified). 

  Recommended for inclusion 

in the safety data sheet if 
there are specific disposal 
requirements above the 
normal expectation for the 
disposal of chemicals. 
Specify the applicable 
regulation. 

Mandatory when supplied to 
the general public. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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76 

material is to be specified. 

P240 

Ground/bond container and 
receiving equipment. 

- if the explosive is electrostatically 
sensitive. 

  Optional unless other conditions 

deem it necessary  

  Recommended for inclusion in the 

safety data sheet  

P250 

Do not subject to 
grinding/shock/.../friction. 

… Manufacturer/supplier to specify 
applicable rough handling. 

  Highly recommended if the 

explosive is mechanically sensitive 

  Optional if the explosive is not 

mechanically sensitive 

P280 

Wear protective gloves/protective 
clothing/eye protection/face 
protection. 

Manufacturer/supplier to specify type of 
equipment. 

- Specify face protection. 

 
 
 
 
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77 

  Protective gloves/protective 

clothing/eye protection highly 
recommended for 
industrial/professional users 

  Face protection highly 
recommended for 
industrial/professional users where 
articles are able to form hazardous 
fragments 

  Optional for explosives supplied to 

the general public 

P234 (add) 

Keep only in original container. 

  Highly recommended  

 
 
 
 
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78 

7.3.2.1 Explosives  

Hazard category 

Signal word   

Hazard statement 

Division 1.4 

Warning 

H204  Fire or projection hazard 

Precautionary Statements 

Prevention 

P210 

Keep away from heat, hot 
surfaces, sparks, open flames 
and other ignition sources. No 
smoking. 

  Highly recommended  

Response 

P370 + P380 

Storage 

P401 

In case of fire: Evacuate area. 

Store … 

  Highly recommended 

P372 

… in accordance with 
local/regional/national/international 
regulations (to be specified). 

Explosion risk in case of fire. 

  Highly recommended for inclusion 

in the safety data sheet. Specify 
the applicable regulation.  

P240 

Ground/bond container and 
receiving equipment. 

- if the explosive is electrostatically 
sensitive. 

  Optional unless other conditions 

deem it necessary  

  Recommended for inclusion in the 

safety data sheet 

P250 

Do not subject to 
grinding/shock/.../friction. 

- except if explosives are 1.4S 
AMMUNITION AND COMPONENTS 
THEREOF. 

  Highly recommended, except 

for division 1.4S, in 
combination with P370+P380: 
Explosion risk in case of 
fire: Evacuate area 

P373 

DO NOT fight fire when fire 
reaches explosives. 

  Recommended  

Disposal 

P501 

Dispose of contents/container 
to … 

… in accordance with local/ 
regional/national/international 
regulations (to be specified). 

  Recommended for inclusion 

in the safety data sheet if 
there are specific disposal 
requirements above the 
normal expectation for the 
disposal of chemicals. Specify 
the applicable regulation. 

  Mandatory when supplied to 

the general public. 

 
 
 
 
 
 
 
 
 
 
 
 
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  Highly recommended for 

inclusion in the safety data 
sheet 

P374 

Fight fire with normal 
precautions from a reasonable 
distance. 

If explosives are 1.4S 
AMMUNITION AND COMPONENTS 
THEREOF. 

  Highly recommended for 

division 1.4S 

79 

… Manufacturer/supplier to specify 
applicable rough handling. 

  Highly recommended if the 

explosive is mechanically 
sensitive 

  Optional if the explosive is not 

mechanically sensitive 

P280 

Wear protective 
gloves/protective clothing/ eye 
protection/ face protection. 

Manufacturer/supplier to specify 
type of equipment. 

- Specify face protection. 

  Protective gloves/protective 

clothing/eye protection highly 
recommended for industrial / 
professional users 

  Face protection highly 

recommended for industrial / 
professional users where articles 
are able to form hazardous 
fragments 

  Optional for explosives supplied 

to the general public 

P234 (add) 

Keep only in original container. 

  Highly recommended 

 
 
 
 
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7.3.2.1 Explosives  

Hazard category 

Signal word   

Hazard statement 

Division 1.5 

Danger 

H205  May mass explode in fire 

Precautionary Statements 

Prevention 

P210 

Keep away from heat, hot 
surfaces, sparks, open flames 
and other ignition sources. No 
smoking. 

  Highly recommended  

P230 

Keep wetted with … 

… Manufacturer/supplier to specify 
appropriate material. 

- if drying out increases explosion 
hazard, except as needed for 
manufacturing or operating 
processes (e.g. nitrocellulose). 

  Highly recommended for 

substances and mixtures which 
are wetted, diluted, dissolved or 
suspended with a phlegmatiser 
in order to reduce or suppress 
their explosive properties 
(desensitized explosives). The 
appropriate material is to be 

Response 

P370 + P380 

Storage 

P401 

In case of fire: Evacuate area. 

Store … 

  Highly recommended 

P372 

… in accordance with 
local/regional/national/international 
regulations (to be specified). 

Explosion risk in case of fire. 

  Highly recommended for inclusion 

in the safety data sheet. Specify 
the applicable regulation 

  Highly recommended, in 

combination with P370+P380: 
Explosion risk in case of 
fire: Evacuate area 

P373 

DO NOT fight fire when fire 
reaches explosives. 

  Recommended 

  Highly recommended for 

inclusion in the safety data 
sheet 

Disposal 

P501 

Dispose of contents/container 
to … 

… in accordance with local/ 
regional/national/international 
regulations (to be specified). 

  Recommended for inclusion 

in the safety data sheet if 
there are specific disposal 
requirements above the 
normal expectation for the 
disposal of chemicals. Specify 
the applicable regulation. 

  Mandatory when supplied to 

the general public. 

 
 
 
 
 
 
 
 
 
 
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81 

specified. 

P240 

Ground/bond container and 
receiving equipment. 

- if the explosive is electrostatically 
sensitive. 

  Optional unless other conditions 

deem it necessary  

  Recommended for inclusion in the 

safety data sheet 

P250 

Do not subject to 
grinding/shock/.../friction. 

… Manufacturer/supplier to specify 
applicable rough handling. 

  Highly recommended if the 

explosive is mechanically 
sensitive 

  Optional if the explosive is not 

mechanically sensitive 

P280 

Wear protective 
gloves/protective clothing/eye 
protection/ face protection. 

Manufacturer/supplier to specify type 
of equipment. 

 
 
 
 
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82 

- Specify face protection. 

  Protective gloves/protective 

clothing/eye protection highly 
recommended for industrial / 
professional users 

  Face protection highly 

recommended for industrial / 
professional users where articles 
are able to form hazardous 
fragments 

  Optional for explosives supplied 

to the general public 

P234 (add) 

Keep only in original container. 

  Highly recommended 

 
 
 
 
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7.3.2.2 Flammable gases (including chemically unstable gases) 

Hazard category 

Signal word   

Hazard statement 

1 

2 

Danger 

Warning 

H220  Extremely flammable gas 

H221  Flammable gas 

Pictogram 
for hazard 
category 1 
only. 

Precautionary Statements 

Prevention 

P210 

Response 

P377 

Storage 

P403 

Disposal 

Keep  away  from  heat,  hot  surfaces, 
sparks,  open 
flames  and  other 
ignition sources. No smoking. 

  Highly recommended  

Leaking  gas  fire:  Do  not  extinguish, 
unless leak can be stopped safely. 

Store in a well-ventilated 
place. 

  Highly recommended 

  Highly recommended 

P381 

Eliminate all ignition sources if safe to 
do so. 

  Recommended 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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7.3.2.2 Flammable gases (including chemically unstable gases) 

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Hazard category 

Signal word   

Hazard statement 

A 

B  

No additional signal word  H230  May react explosively even in the absence of air        

No additional signal word  H231  May react explosively even in the absence of air  

at elevated pressure and/or temperature 

No hazard 
pictogram 

Precautionary Statements 

Prevention 

P202 

Do  not  handle  until  all  safety 
precautions  have  been  read  and 
understood. 

  Highly recommended  

Response 

Storage 

Disposal 

Note: This table lists only the precautionary statement that is assigned due to the chemical instability of the gas. For other precautionary 
statements  that  are  assigned  based  on  the  flammability  see  the  respective  table  for  flammable  gases  (of  cat.  1  and  2)  on  the 
previous page. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
85 

7.3.2.3 Aerosols 

Hazard category 

Signal word   

Hazard statement 

1 

2 

Danger 

Warning  

H222  Extremely flammable aerosol 
H229   Pressurised container: May burst if heated 

H223  Flammable aerosol 
H229   Pressurised container: May burst if heated 

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Response 

Storage 

P410 + P412 

Disposal 

Protect 
from  sunlight.  Do  not 
expose  to  temperatures  exceeding 
50 ºC/122 ºF. 

  Highly recommended, unless 

already assigned in accordance 
with Directive 75/324/EEC 

Precautionary Statements 

Prevention 

P210 

Keep  away  from  heat,  hot  surfaces,  sparks,  open 
flames and other ignition sources. No smoking. 

  Highly recommended, unless already assigned in 

accordance with Directive 75/324/EEC 

P211 

Do  not  spray  on  an  open  flame  or  other  ignition 
source. 

  Highly recommended, unless a similar statement is 
assigned in accordance with Directive 75/324/EEC 

P251 

Do not pierce or burn, even after use. 

  Highly recommended, unless already assigned in 

accordance with Directive 75/324/EEC 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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86 

7.3.2.3 Aerosols 

Hazard category 

Signal word   

Hazard statement 

3 

Warning 

H229 Pressurised container: May burst if heated 

Precautionary Statements 

Prevention 

P210 

Keep  away  from  heat,  hot  surfaces,  sparks,  open 
flames and other ignition sources. No smoking. 

  Highly recommended, unless already assigned in 

accordance with Directive 75/324/EEC 

P251 

Do not pierce or burn, even after use. 

  Highly recommended, unless already assigned in 

accordance with Directive 75/324/EEC 

Response 

Storage 

P410 + P412 

Disposal 

Protect 
from  sunlight.  Do  not 
expose  to  temperatures  exceeding 
50 ºC/ 122ºF. 

  Highly recommended, unless 

already assigned in accordance 
with Directive 75/324/EEC 

 
 
 
 
 
 
 
 
 
 
 
 
 
87 

7.3.2.4 Oxidising gases 

Hazard category 

Signal word   

Hazard statement 

1 

Danger 

H270  May cause or intensify fire; oxidiser 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P220 

Response 

P370 + P376 

Storage 

P403 

Disposal 

Keep/Store away from clothing/…/ 
combustible materials. 

In case of fire: Stop leak if safe to 
do so. 

Store in a well-ventilated 
place. 

… Manufacturer/supplier to specify other 
incompatible materials. 

  Optional 

  Highly recommended 

  Recommended for inclusion in the 

  Highly recommended 

safety data sheet. 

P244 

Keep valves and fittings free from oil and 
grease. 

  Highly recommended 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
88 

7.3.2.5 Gases under pressure 

Hazard category 

Signal word   

Hazard statement 

Compressed gas 

Liquefied gas   

Dissolved gas  

Warning 

Warning 

Warning 

H280  Contains gas under pressure; may explode if heated 

H280  Contains gas under pressure; may explode if heated 

H280  Contains gas under pressure; may explode if heated 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

Response 

Storage 

P410 + P403 

Disposal 

Protect from sunlight. Store in a well-
ventilated place. 

-  may be omitted for gases filled in 
transportable gas cylinders in 
accordance with packing instruction 
P200 of the UN RTDG, Model 
Regulations, unless those gases are 
subject to (slow) decomposition or 
polymerisation 

  Optional 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Guidance on Labelling and Packaging 

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89 

7.3.2.5 Gases under pressure 

Hazard category 

Signal word   

Hazard statement 

Refrigerated liquefied gas  Warning 

H281  Contains refrigerated gas; may cause cryogenic burns or injury 

Precautionary Statements 

Prevention 

P282 

Response 

P336 

Storage 

P403 

Disposal 

Wear cold insulating gloves/face 
shield/eye protection. 

Thaw frosted parts with lukewarm 
water. Do not rub affected area. 

Store in a well-
ventilated place. 

  Highly recommended where liquid 
splashes may occur, e.g. during 
transfer of cryogenic liquids. In this 
case the use of safety glasses with 
side shields and a face shield should 
be indicated in the safety data sheet. 

  Highly recommended 

  Optional 

P315 

Get immediate medical 
advice/attention. 

  Recommended, in combination with 

P336 

 
 
 
 
 
 
 
 
 
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90 

7.3.2.6 Flammable liquids 

Hazard category 

Signal word   

Hazard statement 

1 

2 

3 

Danger 

Danger 

Warning 

H224  Extremely flammable liquid and vapour. 

H225  Highly flammable liquid and vapour. 

H226  Flammable liquid and vapour. 

Precautionary Statements 

Prevention 

P210 

Response 

P303 + P361 + P353 

Storage 

P403 + P235 

Disposal 

P501 

Keep away from heat, hot surfaces, 
sparks, open flames and other ignition 
sources. No smoking. 

  Highly recommended 

IF ON SKIN (or hair): Take off 
immediately all contaminated 
clothing. Rinse skin with 
water/shower. 

P233 

Keep container tightly closed. 

  Optional unless deemed necessary, 
e.g. due to the risk of generating a 
potentially explosive atmosphere 

  Highly recommended for category 1, 

P370 + P378 

unless P404 has already been assigned  

In case of fire: Use … to extinguish. 

  Recommended for category 2, unless 
P404 has already been assigned  

  Optional for category 3  

  Recommended if product is volatile so as 
to generate a potentially explosive 
atmosphere, unless P404 has already 
been assigned 

… Manufacturer/supplier to specify 
appropriate media. 

- if water increases risk. 

  Highly recommended if specific 

extinction media are required or 
appropriate, e.g. if water is 
ineffective or if water increases risk 

P240 

Store in a well-
ventilated place. Keep 
cool. 

  Highly recommended 
for flammable liquids 
category 1 and other 
liquids that are 
volatile so as to 
generate a potentially 
explosive atmosphere 

Dispose of 
contents/container to … 

… in accordance with 
local/regional/ 
national/international regulations 
(to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended to 
specify the site of disposal 
while a reference to the 
applicable legislation is not 
necessary. 

  Recommended for industrial / 
professional users if there 
are specific disposal 
requirements above the 
normal expectation for the 
disposal of chemicals.  

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

It is recommended to specify 
the site of disposal while a 
reference to the applicable 
legislation is not necessary. 

91 

Ground/bond container and receiving 
equipment. 

- if electrostatically sensitive material is for 
reloading. 

- if product is volatile so as to generate 
hazardous atmosphere. 

  Optional unless other conditions deem it 

necessary  

  Recommended for inclusion in the safety 

data sheet 

P241 

Use explosion-proof 
electrical/ventilating/ 
lighting/…/equipment. 

… Manufacturer/supplier to specify other 
equipment. 

  Optional unless other conditions deem it 

necessary  

  Recommended for inclusion in the safety 

data sheet 

P242 

Use only non-sparking tools. 

  Optional unless other conditions deem it 

necessary  

  Recommended for inclusion in the safety 

data sheet  

 
 
 
 
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92 

P243 

Take precautionary measures against 
static discharge. 

  Optional unless other conditions deem it 

necessary  

  Recommended for inclusion in the safety 

data sheet 

P280 

Wear protective gloves/protective 
clothing/eye protection/face 
protection. 

Manufacturer/supplier to specify type of 
equipment. 

- Specify protective gloves and eye/face 
protection. 

  Optional 

 
 
 
 
Guidance on Labelling and Packaging 

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Storage 

Disposal 

93 

7.3.2.7 Flammable solids 

Hazard category 

Signal word   

Hazard statement 

1 

2 

Danger 

Warning 

H228  Flammable solid 

H228  Flammable solid 

Precautionary Statements 

Prevention 

P210 

Response 

P370 + P378 

Keep away from heat, hot surfaces, sparks, 
open flames and other ignition sources. No 
smoking. 

In case of fire: Use … to extinguish. 

… Manufacturer/supplier to specify 
appropriate media. 

  Highly recommended 

- if water increases risk. 

  Highly recommended if specific 

extinction media are required or 
appropriate, e.g. if water is ineffective 
or if water increases risk 

P240 

Ground/bond container and receiving 
equipment. 

- if electrostatically sensitive material is for 
reloading. 

  Optional unless other conditions deem it 

necessary  

  Recommended for inclusion in the safety data 

sheet  

P241 

Use explosion-proof electrical/ventilating/ 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Guidance on Labelling and Packaging 

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94 

lighting/…/equipment. 

… Manufacturer/supplier to specify other 
equipment. 

- if dust clouds can occur. 

  Optional unless other conditions deem it 

necessary  

  Recommended for inclusion in the safety data 

sheet  

P280 

Wear protective gloves/protective 
clothing/eye protection/ face protection. 

Manufacturer/supplier to specify type of equipment. 

- Specify protective gloves and eye/face protection. 

  Optional 

 
 
 
 
95 

7.3.2.8 Self-reactive substances and mixtures 

Hazard category 

Signal word   

Hazard statement 

Type A  

Danger 

H240  Heating may cause an explosion 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P210 

Response 

P370 + P378 

Storage 

P403 + P235 

Disposal 

P501 

Keep away from heat, hot surfaces, 
sparks, open flames and other 
ignition sources. No smoking. 

  Highly recommended 

P220 

Keep/Store away from clothing/…/ 
combustible materials. 

… Manufacturer/supplier to specify other 
incompatible materials. 

  Recommended unless P420 has 

already been assigned 

  Highly recommended for inclusion in 

the safety data sheet 

In case of fire: Use … to extinguish. 

Manufacturer/supplier to specify 
appropriate media. 

- 

if water increases risk. 

  Normally not to be used due to the 

risk of explosion 

P370 + P380 + P375 

In case of fire: Evacuate area. Fight 
fire remotely due to the risk of 
explosion. 

  Highly recommended to use 

P370+P380 only; P375 not to be 
used 

P234 

Keep only in original container. 

  Highly recommended where the 

Store in a well-ventilated 
place. Keep cool. 

Dispose of 
contents/container to … 

…  in  accordance  with  local/ 
regional/national/international 
regulations (to be specified). 

  Recommended for inclusion 
in the safety data sheet if 
there are specific disposal 
requirements above the 
normal expectation for the 
disposal of chemicals. 
Specify the applicable 
regulation. 

  P403: Highly 

recommended 

  P235: Highly 

recommended, in 
combination with P403, 
unless P411 has already 
been assigned 

P411 

Store at temperatures not 
exceeding …ºC/…ºF. 

… Manufacturer/supplier to 
specify temperature. 

  Highly recommended if 
SADT ≤ 50 °C or if 
otherwise deemed 
necessary, in combination 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
96 

container is important for preventing 
or suppressing the effect of 
dangerous reactions or explosion 

P280 

Wear protective gloves/protective 
clothing/eye protection/face 
protection. 

Manufacturer/supplier to specify type of 
equipment. 

- Specify protective gloves and eye/face 
protection. 

  Highly recommended 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

with P403  

P420 

Store away from other 
materials. 

  Recommended where 

incompatible materials are 
likely to produce a 
particular risk. If this 
statement is used, text 
clarifying the incompatible 
materials should be added 
as supplemental 
information. 

  Optional where P220 has 
already been assigned 

 
 
 
 
97 

7.3.2.8 Self-reactive substances and mixtures 

Hazard category 

Signal word   

Hazard statement 

Type B  

Danger 

H241  Heating may cause a fire or explosion 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Response 

P370 + P378 

Storage 

P403 + P235 

Disposal 

P501 

In case of fire: Use … to 
extinguish. 

Store in a well-ventilated 
place. Keep cool. 

Dispose of 
contents/container to … 

Precautionary Statements 

Prevention 

P210 

Keep away from heat, hot surfaces, 
sparks, open flames and other ignition 
sources. No smoking. 

  Highly recommended 

P220 

Keep/Store away from clothing/…/ 
combustible materials. 

… Manufacturer/supplier to specify other 
incompatible materials. 

Manufacturer/supplier to specify 
appropriate media. 

- if water increases risk. 

  Highly recommended if specific 

extinction media are required or 
appropriate, e.g. if water is 
ineffective or if water increases 
risk 

  Recommended unless P420 has already 

been assigned 

P370 + P380 + P375 

  Highly recommended for inclusion in the 

safety data sheet 

P234 

Keep only in original container. 

In case of fire: Evacuate area. 
Fight fire remotely due to the risk 
of explosion. 

  Highly recommended 

  P403: Highly recommended 

  P235: Highly recommended, 
in combination with P403, 
unless P411 has already 
been assigned 

P411 

Store at temperatures not 
exceeding …ºC/…ºF. 

… Manufacturer/supplier to 
specify temperature. 

  Highly recommended if SADT 

≤ 50 °C or if otherwise 
deemed necessary, in 
combination with P403  

… in accordance with 
local/regional/ 
national/international 
regulations (to be 
specified). 

  Mandatory for the 

general public if the 
substance / mixture is 
subject to legislation 
on hazardous waste. It 
is recommended to 
specify the site of 
disposal while a 
reference to the 
applicable legislation is 
not necessary. 

  Recommended for 

inclusion in the safety 

 
 
 
 
 
 
 
 
 
 
 
 
98 

  Highly recommended  

P280 

Wear protective gloves/protective 
clothing/eye protection/face protection. 

Manufacturer/supplier to specify type of 
equipment. 

- 

Specify protective gloves and eye/face 
protection. 

  Highly recommended 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

data sheet if there are 
specific disposal 
requirements above 
the normal expectation 
for the disposal of 
chemicals. Specify the 
applicable regulation. 

P420 

Store away from other 
materials. 

  Recommended where 

incompatible materials are 
likely to produce a particular 
risk. If this statement is 
used, text clarifying the 
incompatible materials 
should be added as 
supplemental information 

  Optional where P220 has 
already been assigned 

 
 
 
 
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99 

7.3.2.8 Self-reactive substances and mixtures 

Hazard category 

Signal word   

Hazard statement 

Type C  

Type D  

Type E  

Type F  

Danger 

Danger 

Warning 

Warning 

H242  Heating may cause a fire  

H242  Heating may cause a fire  

H242  Heating may cause a fire  

H242  Heating may cause a fire  

Precautionary Statements 

Prevention 

P210 

Keep away from heat, hot surfaces, 
sparks, open flames and other 
ignition sources. No smoking. 

  Highly recommended 

P220 

Keep/Store away from clothing/…/ 
combustible materials. 

… Manufacturer/supplier to specify other 
incompatible materials. 

  Recommended unless P420 has 

already been assigned 

  Highly recommended for inclusion in 

the safety data sheet 

P234 

Response 

P370 + P378 

Storage 

P403 + P235 

Disposal 

P501 

In case of fire: Use … to 
extinguish. 

Store in a well-ventilated 
place. Keep cool. 

Dispose of contents/container 
to … 

Manufacturer/supplier to specify 
appropriate media. 

  P403: Highly 

recommended 

- if water increases risk. 

  P235: Highly 

  Highly recommended if specific 

extinction media are required or 
appropriate, e.g. if water is 
ineffective or if water increases 
risk 

recommended, in 
combination with P403, 
unless P411 has already 
been assigned 

P411 

Store at temperatures not 
exceeding …ºC/…ºF. 

… Manufacturer/supplier to 
specify temperature. 

  Highly recommended if 

… in accordance with 
local/regional/ 
national/international regulations 
(to be specified). 

  Mandatory for the general 

public if the substance/mixture 
is subject to legislation on 
hazardous waste. It is 
recommended to specify the 
site of disposal while a 
reference to the applicable 
legislation is not necessary. 

  Recommended for inclusion in 
the safety data sheet if there 
are specific disposal 
requirements above the 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
100 

Keep only in original container. 

  Highly recommended  

P280 

Wear protective gloves/protective 
clothing/eye protection/face 
protection. 

Manufacturer/supplier to specify type of 
equipment. 

- 

Specify protective gloves and 
eye/face protection. 

  Highly recommended 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

normal expectation for the 
disposal of chemicals. Specify 
the applicable regulation. 

SADT ≤ 50 °C or if 
otherwise deemed 
necessary, in 
combination with P403.  

P420 

Store away from other 
materials. 

  Recommended where 

incompatible materials 
are likely to produce a 
particular risk. If this 
statement is used, text 
clarifying the 
incompatible materials 
should be added as 
supplemental 
information 

  Optional where P220 has 
already been assigned 

 
 
 
 
101 

7.3.2.9 Pyrophoric liquids 

Hazard category 

Signal word   

Hazard statement 

1 

Danger 

H250  Catches fire spontaneously if exposed to air  

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P210 

Response 

P302 + P334 

Storage 

P422 

Disposal 

Keep away from heat, hot surfaces, 
sparks, open flames and other 
ignition sources. No smoking. 

IF ON SKIN: Immerse in cool 
water/wrap in wet bandages. 

  Highly recommended 

  Highly recommended 

P222 

Do not allow contact with air. 

  Optional unless emphasis of the 
hazard statement is desired 

P280 

Wear protective gloves/protective 
clothing/eye protection/face 
protection. 

Manufacturer/supplier to specify type of 
equipment. 

- 

Specify protective gloves and 
eye/face protection. 

P370 + P378 

In case of fire: Use … to extinguish. 

… Manufacturer/supplier to specify 
appropriate media. 

- if water increases risk. 

  Highly recommended if specific 

extinction media are required or 
appropriate, e.g. if water is ineffective 
or if water increases risk 

Store contents under …   

… Manufacturer/supplier to 
specify appropriate liquid or 
inert gas. 

  Recommended if a specific 

inert gas or liquid is 
required, unless P231 has 
already been assigned 

  Highly recommended for 

inclusion in the safety data 
sheet 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
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102 

  Highly recommended 

P231 (add) 

Handle under inert gas. 

  Recommended, unless P422 has 

already been assigned 

  Highly recommended for inclusion in 

the safety data sheet 

 
 
 
 
103 

7.3.2.10 Pyrophoric solids 

Hazard category 

Signal word   

Hazard statement 

1 

Danger 

H250  Catches fire spontaneously if exposed to air 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P210 

Response 

P335 + P334 

Storage 

P422 

Disposal 

Keep away from heat, hot surfaces, sparks, 
open flames and other ignition sources. No 
smoking. 

Brush off loose particles from skin. 
Immerse in cool water/wrap in wet 
bandages. 

  Highly recommended 

  Highly recommended 

P222 

P370 + P378 

Do not allow contact with air. 

In case of fire: Use … to extinguish. 

  Optional unless emphasis of the hazard 

statement is desired 

… Manufacturer/supplier to specify 
appropriate media. 

P280 

Wear protective gloves/protective 
clothing/eye protection/face protection. 

Manufacturer/supplier to specify type of 
equipment. 

- 

Specify protective gloves and eye/face 
protection. 

  Highly recommended 

- if water increases risk. 

  Highly recommended if specific 

extinction media are required or 
appropriate, e.g. if water is 
ineffective or if water increases risk 

Store contents under …   

… Manufacturer/supplier to 
specify appropriate liquid or inert 
gas. 

  Recommended if a specific 

inert gas or liquid is 
required, unless P231 has 
already been assigned 

  Highly recommended for 

inclusion in the safety data 
sheet 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
104 

P231 (add) 

Handle under inert gas. 

  Recommended, unless P422 has already been 

assigned 

  Highly recommended for inclusion in the 

safety data sheet 

Guidance on Labelling and Packaging 

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105 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

7.3.2.11 Self-heating substances and mixtures 

Hazard category 

Signal word   

Hazard statement 

1 

2 

Danger 

Warning 

H251  Self-heating; may catch fire 

H252  Self-heating in large quantities; may catch fire 

Precautionary Statements 

Prevention 

P235 + P410 

Response 

Storage 

P407 

Disposal 

Keep cool. Protect from sunlight. 

Maintain air gap between stacks/pallets. 

  Highly recommended for the general 

  Highly recommended 

public 

  Optional for industrial/professional 
users if P413 has already been 
assigned 

P280 

Wear protective gloves/protective 
clothing/eye protection/face 
protection. 

Manufacturer/supplier to specify type of 
equipment. 

- Specify protective gloves and eye/face 
protection. 

  Optional 

P413 

Store bulk masses greater than … kg/…lbs at 
temperatures not exceeding …ºC/…ºF. 

… Manufacturer/supplier to specify mass and 
temperature. 

  Highly recommended if the manufacturer has 

specific information 

P420 

Store away from other materials. 

  Recommended where incompatible materials are 

likely to produce a particular risk. If this statement 
is used, text clarifying the incompatible materials 
should be added as supplemental information 

  Optional where P220 has already been assigned 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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106 

7.3.2.12 Substances and mixtures which, in contact with water, emit flammable gases 

Hazard category 

Signal word   

Hazard statement 

1 

2 

Danger 
                                         ignite spontaneously 

H260  In contact with water releases flammable gases which may 

Danger 

H261  In contact with water releases flammable gases 

Precautionary Statements 

Prevention 

P223 

Response 

P335 + P334 

Storage 

P402 + P404 

Disposal 

P501 

Do not allow contact with water. 

   Optional unless emphasis of the hazard statement 

is desired  

P231 + P232 

Handle under inert gas. Protect from moisture. 

   Highly recommended for substances and mixtures 
which react readily with moisture in air, where 
special emphasis is required 

P280 

Wear protective gloves/protective clothing/eye 
protection/face protection. 

Manufacturer/supplier to specify type of equipment. 

- 

Specify protective gloves and eye/face protection. 

Brush off loose particles 
from skin. Immerse in 
cool water/wrap in wet 
bandages. 

  Highly recommended but 
do not use the phrase  
“wrap in wet bandages” 

P370 + P378 

In case of fire: Use … to 
extinguish. 

… Manufacturer/supplier to 
specify appropriate media. 

- if water increases risk. 

  Highly recommended if 

specific extinction media 

Store in a dry place. Store 
in a closed container. 

Dispose of 
contents/container to … 

  Recommended, unless 
P231 has already been 
assigned 

  Highly recommended for 

inclusion in the safety data 
sheet 

… in accordance with 
local/regional/ 
national/international 
regulations (to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended 
to specify the site of 
disposal while a reference 
to the applicable legislation 
is not necessary. 

  Recommended for 

inclusion in the safety data 

 
 
 
 
 
 
 
 
 
 
 
 
107 

  Recommended 

are required or 
appropriate 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

sheet if there are specific 
disposal requirements 
above the normal 
expectation for the 
disposal of chemicals. 
Specify the applicable 
regulation. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
108 

7.3.2.12 Substances and mixtures which, in contact with water, emit flammable gases 

Hazard category 

Signal word   

Hazard statement 

3 

Warning 

H261  In contact with water releases flammable gases 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P231 + P232 

Response 

P370 + P378 

Storage 

P402 + P404 

Disposal 

P501 

Handle  under  inert  gas.  Protect 
from moisture. 

In case of fire: Use … to 
extinguish. 

Store in a dry place. Store in a 
closed container. 

Dispose of contents/container 
to … 

… Manufacturer/supplier to specify 
appropriate media. 

  Recommended, unless P231 has 

already been assigned 

- if water increases risk. 

  Highly recommended for 

  Highly recommended if specific 

extinction media are required or 
appropriate  

inclusion in the safety data 
sheet 

  Highly recommended for 

substances and mixtures which 
react readily with moisture in air, 
where special emphasis is required 

P280 

Wear protective gloves/protective 
clothing/eye protection/face 
protection. 

Manufacturer/supplier  to  specify  type 
of equipment. 

- 

Specify protective gloves and 
eye/face protection. 

  Recommended 

… in accordance with local/ 
regional/national/international 
regulations (to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended to 
specify the site of disposal 
while a reference to the 
applicable legislation is not 
necessary. 

  Recommended for inclusion in 
the safety data sheet if there 
are specific disposal 
requirements above the 
normal expectation for the 
disposal of chemicals. Specify 
the applicable regulation. 

 
 
 
 
 
 
 
 
 
109 

Guidance on Labelling and Packaging 

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7.3.2.13 Oxidising liquids 

Hazard category 

Signal word   

Hazard statement 

1 

Danger 

H271  May cause fire or explosion; strong oxidiser 

Precautionary Statements 

Prevention 

P210 

Response 

P306 + P360 

Storage 

Disposal 

P501 

Keep away from heat, hot surfaces, sparks, 
open flames and other ignition sources. No 
smoking. 

  Highly recommended 

P220 

Keep/Store away from clothing/…/ 
combustible materials. 

- 

specify to keep away from clothing and other 
combustible materials. 

  Optional where P221 has already been assigned 

  Highly recommended for inclusion in the safety 

data sheet 

P221 

Take any precaution to avoid mixing with 
combustibles/… 

… Manufacturer/supplier to specify incompatible 

IF ON CLOTHING: Rinse 
immediately contaminated 
clothing and skin with plenty of 
water before removing clothes. 

  Recommended 

P371 + P380 + P375 

In case of major fire and large 
quantities: Evacuate area. Fight 
fire remotely due to the risk of 
explosion. 

  Highly recommended 

P370 + P378 

In case of fire: Use … to 
extinguish. 

… Manufacturer/supplier to specify 
appropriate media. 

Dispose of 
contents/container to … 

… in accordance with 
local/regional/ 
national/international regulations 
(to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended to 
specify the site of disposal 
while a reference to the 
applicable legislation is not 
necessary. 

  Recommended for inclusion 

in the safety data sheet if 
there are specific disposal 
requirements above the 
normal expectation for the 

 
 
 
 
 
 
 
 
 
 
 
 
Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

- if water increases risk. 

disposal of chemicals 

  Highly recommended if specific 

extinction media are required or 
appropriate, e.g. if water is 
ineffective or if water increases 
risk 

110 

materials. 

  Highly recommended  

P280 

Wear protective gloves/protective 
clothing/eye protection/ face protection. 

Manufacturer/supplier to specify type of equipment. 

- 

Specify protective gloves and eye/face 
protection. 

  Recommended 

P283 

Wear fire/flame resistant/retardant clothing. 

  Recommended for inclusion in the safety data 

sheet 

 
 
 
 
111 

7.3.2.13 Oxidising liquids 

Hazard category 

Signal word   

Hazard statement 

2 

3 

Danger 

Warning 

H272  May intensify fire; oxidiser 

H272  May intensify fire; oxidiser 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P210 

Keep away from heat, hot surfaces, sparks, 
open flames and other ignition sources. No 
smoking. 

  Highly recommended 

P220 

Keep/Store away from clothing/…/ 
combustible materials. 

… Manufacturer/supplier to specify other 
incompatible materials. 

  Optional where P221 has already been 

assigned 

  Highly recommended for inclusion in the safety 

data sheet 

P221 

Take any precaution to avoid mixing with 
combustibles/… 

Response 

P370 + P378 

Storage 

Disposal 

P501 

In case of fire: Use … to 
extinguish. 

… Manufacturer/supplier to specify 
appropriate media. 

- if water increases risk. 

  Highly recommended if specific 

extinction media are required 
or appropriate, e.g. if water is 
ineffective or if water increases 
risk 

Dispose of 
contents/container to … 

… in accordance with 
local/regional/ 
national/international regulations 
(to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended to 
specify the site of disposal 
while a reference to the 
applicable legislation is not 
necessary. 

  Recommended for inclusion 

in the safety data sheet if 
there are specific disposal 
requirements above the 
normal expectation for the 
disposal of chemicals. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Specify the applicable 
regulation. 

112 

… Manufacturer/supplier to specify incompatible 
materials. 

  Highly recommended  

P280 

Wear protective gloves/protective 
clothing/eye protection/ face protection. 

Manufacturer/supplier to specify type of 
equipment. 

- 

Specify protective gloves and eye/face 
protection. 

  Recommended 

 
 
 
 
113 

7.3.2.14 Oxidising solids 

Hazard category 

Signal word   

Hazard statement 

1 

Danger 

H271  May cause fire or explosion; strong oxidizer 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P210 

Response 

P306 + P360 

Storage 

Disposal 

P501 

Keep away from heat, hot surfaces, sparks, 
open flames and other ignition sources. No 
smoking. 

  Highly recommended 

P220 

Keep/Store away from clothing/…/ 
combustible materials. 

- 

specify to keep away from clothing and 
other combustible materials. 

  Optional where P221 has already been 

assigned 

IF ON CLOTHING: Rinse immediately 
contaminated clothing and skin with 
plenty of water before removing 
clothes. 

  Recommended 

P371 + P380 + P375 

In case of major fire and large 
quantities: Evacuate area. Fight fire 
remotely due to the risk of 
explosion. 

  Highly recommended 

  Highly recommended for inclusion in the 

P370 + P378 

safety data sheet 

P221 

Take any precaution to avoid mixing with 
combustibles/… 

In case of fire: Use … to extinction. 

… Manufacturer/supplier to specify 
appropriate media. 

- if water increases risk. 

Dispose of 
contents/container to … 

… in accordance with 
local/regional/ 
national/international regulations 
(to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended to 
specify the site of disposal 
while a reference to the 
applicable legislation is not 
necessary. 

  Recommended for inclusion 

in the safety data sheet if 
there are specific disposal 
requirements above the 
normal expectation for the 
disposal of chemicals. 

 
 
 
 
 
 
 
 
 
 
 
 
Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

  Highly recommended if specific 

extinction media are required or 
appropriate, e.g. if water is 
ineffective or if water increases risk 

Specify the applicable 
regulation. 

114 

… Manufacturer/supplier to specify incompatible 
materials. 

  Highly recommended  

P280 

Wear protective gloves/protective 
clothing/eye protection/face protection. 

Manufacturer/supplier to specify type of 
equipment. 

- 

Specify protective gloves and eye/face 
protection. 

  Recommended 

P283 

Wear fire/flame resistant/retardant 
clothing. 

  Recommended for inclusion in the safety 

data sheet 

 
 
 
 
115 

7.3.2.14 Oxidising solids 

Hazard category 

Signal word   

Hazard statement 

2 

3 

Danger 

Warning 

H272  May intensify fire; oxidiser 

H272  May intensify fire; oxidiser 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P210 

Keep away from heat, hot surfaces, sparks, 
open flames and other ignition sources. No 
smoking. 

  Highly recommended 

P220 

Keep/Store away from clothing/…/ 
combustible materials. 

… Manufacturer/supplier to specify other 
incompatible materials. 

  Optional where P221 has already been assigned  

P221 

Take any precaution to avoid mixing with 
combustibles/… 

… Manufacturer/supplier to specify incompatible 
materials. 

  Highly recommended  

Response 

P370 + P378 

Storage 

Disposal 

P501 

In case of fire: Use … to 
extinguish. 

… Manufacturer/supplier to specify 
appropriate media. 

- if water increases risk. 

  Highly recommended if specific 

extinction media are required or 
appropriate 

Dispose of 
contents/container to … 

accordance  with 

… 
in 
local/regional/ 
national/international 
regulations (to be specified). 

  Mandatory for the general 
public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended 
to specify the site of 
disposal while a reference 
to the applicable 
legislation is not 
necessary. 

  Recommended for 

inclusion in the safety 
data sheet if there are 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
116 

P280 

Wear protective gloves/protective 
clothing/eye protection/face protection. 

Manufacturer/supplier to specify type of equipment. 

- 

Specify protective gloves and eye/face 
protection. 

  Recommended 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

specific disposal 
requirements above the 
normal expectation for the 
disposal of chemicals. 
Specify the applicable 
regulation. 

 
 
 
 
117 

7.3.2.15 Organic peroxides 

Hazard category 

Signal word   

Hazard statement 

Type A  

Danger 

H240  Heating may cause an explosion 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P210 

Keep away from heat, hot surfaces, 
sparks, open flames and other 
ignition sources. No smoking. 

  Highly recommended 

P220 

Keep/Store away from clothing/…/ 
combustible materials. 

… Manufacturer/supplier to specify other 
incompatible materials. 

  Recommended 

  Highly recommended for inclusion in 

the safety data sheet 

P234 

Keep only in original container. 

  Highly recommended where the 

container is important for preventing 

Response 

Storage 

P370 + P380  (add) 

P411 + P235 

Disposal 

P501 

In case of fire: Evacuate 
area.  

Store at temperatures not exceeding 
…ºC/…ºF. Keep cool. 

Dispose of 
contents/container to … 

  Highly recommended 

… Manufacturer/supplier to specify 
temperature. 

  P411: Highly recommended if SADT ≤ 

50 °C or if otherwise deemed 
necessary, in combination with P403  

  P235: Highly recommended for other 
cases, in combination with P403 

P403 (add) 

Store in a well-ventilated place. 

  Highly recommended, in combination 

with P411 or P235 

P410 

Protect from sunlight. 

  Optional if P411 or P235 has already 

… in accordance with 
local/regional/ 
national/international 
regulations (to be specified). 

  Recommended for 

inclusion in the safety 
data sheet if there are 
specific disposal 
requirements above the 
normal expectation for 
the disposal of 
chemicals. Specify the 
applicable regulation. 

 
 
 
 
 
 
 
 
 
 
 
 
Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

118 

or suppressing the effect of 
dangerous reactions or explosion 

P280 

Wear protective gloves/protective 
clothing/eye protection/face 
protection. 

Manufacturer/supplier to specify type of 
equipment. 

- 

Specify protective gloves and 
eye/face protection. 

  Highly recommended 

been assigned 

P420 

Store away from other materials. 

  Recommended where incompatible 
materials are likely to produce a 
particular risk. If this statement is 
used, text clarifying the incompatible 
materials should be added as 
supplemental information 

  Optional where P220 has already been 

assigned 

 
 
 
 
119 

7.3.2.15 Organic peroxides 

Hazard category 

Signal word   

Hazard statement 

Type B  

Danger 

H241  Heating may cause a fire or explosion 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P210 

Response 

Storage 

P370 + P380 + P375 (add) 

P411 + P235 

Disposal 

P501 

Store at temperatures not 
exceeding …ºC/…ºF. Keep cool. 

Dispose of 
contents/container to … 

Keep away from heat, hot surfaces, 
sparks, open flames and other 
ignition sources. No smoking. 

In case of fire: Evacuate 
area. Fight fire remotely 
due to the risk of explosion. 

  Highly recommended 

  Highly recommended 

P220 

P370 + P378 (add) 

Keep/Store away from clothing/…/ 
combustible materials. 

In case of fire: Use … to 
extinguish. 

… Manufacturer/supplier to specify other 
incompatible materials. 

… Manufacturer/supplier to 
specify appropriate media. 

  Recommended 

-  if water increases risk. 

… Manufacturer/supplier to specify 
temperature. 

  P411: Highly recommended if 
SADT ≤ 50 °C or if otherwise 
deemed necessary, in combination 
with P403  

  P235: Highly recommended for 

other cases, in combination with 
P403 

P234 

Keep only in original container. 

  Highly recommended  

P280 

Wear protective gloves/protective 

  Highly recommended if 

P403 (add) 

specific extinction media 
are required or 
appropriate, e.g. if water is 
ineffective or if water 
increases risk 

Store in a well-ventilated place. 

  Highly recommended, in 

combination with P411 or P235 

P410 

… in accordance with 
local/regional/ 
national/international regulations 
(to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended to 
specify the site of disposal 
while a reference to the 
applicable legislation is not 
necessary. 

  Recommended for inclusion 

in the safety data sheet if 
there are specific disposal 
requirements above the 
normal expectation for the 
disposal of chemicals. 

 
 
 
 
 
 
 
 
 
 
120 

clothing/eye protection/face 
protection. 

Manufacturer/supplier to specify type of 
equipment. 

- 

Specify protective gloves and 
eye/face protection. 

  Highly recommended 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Specify the applicable 
regulation. 

Protect from sunlight. 

  Optional if P411 or P235 has 

already been assigned 

P420 

Store away from other materials. 

  Recommended where incompatible 
materials are likely to produce a 
particular risk. If this statement is 
used, text clarifying the 
incompatible materials should be 
added as supplemental 
information 

  Optional where P220 has already 

been assigned 

 
 
 
 
Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

121 

7.3.2.15 Organic peroxides 

Hazard category 

Signal word   

Hazard statement 

Type C  

Type D  

Type E  

Type F  

Danger 

Danger 

Warning 

Warning 

H242  Heating may cause a fire 

H242  Heating may cause a fire 

H242  Heating may cause a fire 

H242  Heating may cause a fire 

Precautionary Statements 

Prevention 

P210 

Keep away from heat, hot surfaces, 
sparks, open flames and other 
ignition sources. No smoking. 

  Highly recommended 

P220 

Keep/Store away from clothing/…/ 
combustible materials. 

… Manufacturer/supplier to specify other 
incompatible materials. 

  Recommended 

P234 

Keep only in original container. 

  Highly recommended  

P280 

Response 

Storage 

P370 + P378 (add) 

P411 + P235 

Disposal 

P501 

In case of fire: Use … to 
extinguish. 

Store at temperatures not 
exceeding …ºC/…ºF. Keep cool. 

Dispose of 
contents/container to … 

… Manufacturer/supplier to 
specify appropriate media. 

… Manufacturer/supplier to specify 
temperature. 

- if water increases risk. 

  Highly recommended if 

specific extinction media 
are required or 
appropriate, e.g. if water is 
ineffective or if water 
increases risk 

  P411: Highly recommended if 
SADT ≤ 50 °C or if otherwise 
deemed necessary, in combination 
with P403  

  P235: Highly recommended for 

other cases, in combination with 
P403 

P403 (add) 

Store in a well-ventilated place. 

  Highly recommended, in 

combination with P411 or P235 

P410 

… in accordance with 
local/regional/ 
national/international regulations 
(to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended to 
specify the site of disposal 
while a reference to the 
applicable legislation is not 
necessary. 

  Recommended for inclusion 

in the safety data sheet if 
there are specific disposal 
requirements above the 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
122 

Wear protective gloves/protective 
clothing/eye protection/face 
protection. 

Manufacturer/supplier to specify type of 
equipment. 

- 

Specify protective gloves and 
eye/face protection. 

  Highly recommended 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Protect from sunlight. 

  Optional if P411 or P235 has 

already been assigned 

normal expectation for the 
disposal of chemicals. 
Specify the applicable 
regulation. 

P420 

Store away from other materials. 

  Recommended where incompatible 
materials are likely to produce a 
particular risk. If this statement is 
used, text clarifying the 
incompatible materials should be 
added as supplemental 
information 

  Optional where P220 has already 

been assigned 

 
 
 
 
123 

7.3.2.16 Corrosive to metals 

Hazard category 

Signal word   

Hazard statement 

1 

Warning 

H290  May be corrosive to metals 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P234 

Response 

P390 

Storage 

P406 

Disposal 

Keep only in original container. 

  Recommended for the general public 

  Optional for industrial / professional 

Absorb spillage to prevent 
material damage. 

  Recommended 

users  

  Recommended for inclusion in the 

safety data sheet 

Store in a corrosive resistant/… 
container with a resistant inner 
liner. 

… Manufacturer/supplier to specify 
other compatible materials. 

  Optional 

  Do not use if P234 has already 

been assigned 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

124 

7.3.3 Specific precautionary statements for health hazards 

7.3.3.1 Acute Toxicity – Oral 

Hazard category 

Signal word   

Hazard statement 

1 

2 

3 

Danger 

Danger 

Danger 

H300  Fatal if swallowed 

H300  Fatal if swallowed 

H301  Toxic if swallowed 

Precautionary Statements 

Prevention 

P264 

Wash … thoroughly after handling. 

Manufacturer/supplier to specify parts of 
the body to be washed after handling. 

  Highly recommended for the general 

public  

  Recommended for industrial / 

professional users unless P280 is 
assigned due to other reasons 

P270 

Response 

P301 + P310 

Storage 

P405 

Disposal 

P501 

IF SWALLOWED: Immediately call a 
POISON CENTER /doctor/... 

…Manufacturer/supplier to specify the 
appropriate source of emergency 
medical advice. 

Store locked up. 

  Highly recommended for 

the general public 

  Optional for industrial / 
professional users  

  Highly recommended 

P321 

Specific treatment (see … on this 
label). 

Do not eat, drink or smoke when 
using this product. 

… Reference to supplemental first aid 
instruction. 

  Highly recommended for the general 

public for categories 1 and 2 

- if immediate administration of antidote 
is required.  

  Recommended for the general public 

  Highly recommended only in 

Dispose of contents/container 
to … 

… in accordance with local/ 
regional/national/international 
regulations (to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended to 
specify the site of disposal 
while a reference to the 
applicable legislation is not 
necessary. 

  Recommended for industrial / 
professional users if there are 
specific disposal 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

requirements above the 
normal expectation for the 
disposal of chemicals. . It is 
recommended to specify the 
site of disposal while a 
reference to the applicable 
legislation is not necessary. 

125 

for category 3 

  Optional for industrial / professional 

users 

exceptional cases where specific 
treatment is known and required 

P330 in combination with P301 

  Recommended for inclusion in the 

safety data sheet 

Rinse mouth. 

  Highly recommended for the general 

public for categories 1 and 2 unless 
P301+P330+P331 is assigned 

  Recommended for the general public 

for category 3 unless 
P301+P330+P331 is assigned 

  Recommended for industrial / 

professional users for categories 1 
and 2 unless P301+P330+P331 is 
assigned 

  Optional for industrial / professional 

users for category 3 

 
 
 
 
126 

7.3.3.1 Acute Toxicity - Oral 

Hazard category 

Signal word   

Hazard statement 

4 

Warning 

H302  Harmful if swallowed 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P264 

Wash … thoroughly after handling. 

Manufacturer/supplier to specify parts of 
the body to be washed after handling. 

  Recommended for the general public 
unless P280 is assigned due to other 
reasons 

  Optional for industrial / professional 

users 

P270 

Do not eat, drink or smoke when 
using this product. 

  Recommended for the general public 

  Optional for industrial / professional  

users 

  Recommended for inclusion in the 

Response 

P301 + P312 

Storage 

Disposal 

P501 

IF SWALLOWED: Call a POISON 
CENTER/doctor/…/if you feel unwell. 

…Manufacturer/supplier to specify the 
appropriate source of emergency medical 
advice. 

  Optional  

P330  

Rinse mouth. 

  Optional 

Dispose of contents/container 
to … 

… in accordance with 
local/regional/ 
national/international regulations 
(to be specified) 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended to 
specify the site of disposal 
while a reference to the 
applicable legislation is not 
necessary. 

  Recommended for industrial / 
professional users if there are 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
127 

safety data sheet 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

specific disposal requirements 
above the normal expectation 
for the disposal of chemicals. 
It is recommended to specify 
the site of disposal while a 
reference to the applicable 
legislation is not necessary. 

 
 
 
 
 
128 

7.3.3.1 Acute Toxicity – Dermal 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Hazard category 

Signal word   

Hazard statement 

1 

2 

Danger 

Danger 

H310  Fatal in contact with skin 

H310  Fatal in contact with skin 

Precautionary Statements 

Prevention 

P262 

Response 

P302 + P352 

Storage 

P405 

Disposal 

P501 

Do not get in eyes, on skin, or on clothing. 

  Highly recommended  

P264 

Wash … thoroughly after handling. 

Manufacturer / supplier to specify parts of the 
body to be washed after handling. 

IF ON SKIN: Wash with plenty of 
water/… 

…Manufacturer/supplier may specify 
a cleansing agent if appropriate, or 
may recommend an alternative 
agent in exceptional cases if water is 
clearly inappropriate. 

Store locked up. 

  Highly recommended 
for the general public 

  Optional for 

industrial/professional 
users  

  Recommended for the general 

  Highly recommended for the general public 

public 

  Highly recommended for industrial / 

professional users unless P280 has already 
been assigned  

P270 

Do not eat, drink or smoke when using this 
product. 

  Highly recommended for the general public 

  Optional for industrial / professional users.   

  Recommended for inclusion in 

the safety data sheet 

P310 

Immediately call a POISON 
CENTER/doctor/... 

…Manufacturer/supplier to specify 
the appropriate source of emergency 
medical advice. 

  Highly recommended, in 

Dispose of 
contents/container to … 

… in accordance with 
local/regional/ 
national/international 
regulations (to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended 
to specify the site of 
disposal while a reference 
to the applicable legislation 
is not necessary. 

  Recommended for 

inclusion in the safety data 
sheet if there are specific 
disposal requirements 
above the normal 
expectation for the 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

disposal of chemicals. 
Specify the applicable 
regulation. 

129 

  Recommended for inclusion in the safety data 

combination with P302+P352 

sheet 

P280 

P321 

Wear protective gloves/protective 
clothing/eye protection/face protection. 

Specific treatment (see … on this 
label). 

Manufacturer/supplier to specify type of 
equipment.  

- Specify protective gloves/clothing.  

  Highly recommended 

Reference to supplemental first aid 
instruction. 
- if immediate measures, such as 
specific cleansing agent, are 
advised 

  Highly recommended only in 

exceptional cases where specific 
treatment is known and required 

P361 + P364 

Take off immediately all 
contaminated clothing and wash 
it before reuse 

  Recommended 

 
 
 
 
 
130 

7.3.3.1 Acute Toxicity – Dermal 

Hazard category 

Signal word   

Hazard statement 

3 

Danger 

H311  Toxic in contact with skin 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P280 

Wear protective gloves/protective 
clothing/eye protection/face 
protection. 

Manufacturer/supplier to specify type of 
equipment.  

- Specify protective gloves/clothing.  

  Highly recommended  

Response 

P302 + P352 

Storage 

P405 

Disposal 

P501 

Store locked up. 

  Highly recommended for 

the general public 

  Optional for industrial / 
professional users  

IF ON SKIN: Wash with plenty of 
water/… 

…Manufacturer/supplier may specify a 
cleansing agent if appropriate, or may 
recommend an alternative agent in 
exceptional cases if water is clearly 
inappropriate. 

  Recommended for the general public 

  Recommended for inclusion in the safety 

data sheet  

P312 

Call a POISON CENTER/doctor/…/ if 
you feel unwell. 

…Manufacturer/supplier to specify the 
appropriate source of emergency medical 
advice. 

Dispose of 
contents/container to … 

… in accordance with 
local/regional/ 
national/international 
regulations (to be specified). 

  Mandatory for the 

general public if the 
substance / mixture is 
subject to legislation on 
hazardous waste. It is 
recommended to specify 
the site of disposal while 
a reference to the 
applicable legislation is 
not necessary. 

  Recommended for 

industrial / professional 
users if there are specific 
disposal requirements 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

above the normal 
expectation for the 
disposal of chemicals. It 
is recommended to 
specify the site of 
disposal while a 
reference to the 
applicable legislation is 
not necessary. 

131 

  Recommended unless P310, P311 or 

P313 is assigned 

P321 

Specific treatment (see … on this label). 

…Reference to supplemental first aid 
instruction. 
- if immediate measures, such as specific 

cleansing agent, are advised 

  Highly recommended only in exceptional 
cases where specific treatment is known 
and required 

P361+P364 

Take off immediately all contaminated 
clothing and wash it before reuse. 

  Recommended  

 
 
 
 
 
 
 
 
132 

7.3.3.1 Acute Toxicity – Dermal 

Hazard category 

Signal word   

Hazard statement 

4 

Warning 

H312  Harmful in contact with skin 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P280 

Response 

P302 + P352 

Wear protective gloves/ 
protective clothing /eye 
protection/face protection. 

Manufacturer/supplier to specify type 
of equipment.  

IF ON SKIN: Wash with plenty of water/… 

…Manufacturer/supplier may specify a cleansing 
agent if appropriate, or may recommend an 
alternative agent in exceptional cases if water is 
clearly inappropriate. 

- Specify protective gloves/clothing.  

  Optional 

  Recommended 

P312 

Call a POISON CENTER/doctor/…/if you feel 
unwell. 

…Manufacturer/supplier to specify the appropriate 
source of emergency medical advice. 

  Recommended unless P310, P311 or P313 is 

assigned 

P321 

Specific treatment (see … on this label). 

…Reference to supplemental first aid instruction. 

Storage 

Disposal 

P501 

Dispose of 
contents/container to … 

… in accordance with 
local/regional/national/internatio
nal regulations (to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended to 
specify the site of disposal 
while a reference to the 
applicable legislation is not 
necessary. 

  Recommended for industrial / 
professional users if there 
are specific disposal 
requirements above the 
normal expectation for the 
disposal of chemicals. It is 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
133 

- if immediate measures, such as specific 

cleansing agent, are advised. 

  Highly recommended  only in exceptional 

cases where specific treatment is known and 
required 

P362 +  P364 

Take off contaminated clothing and wash it 
before reuse. 

  Optional 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

recommended to specify the 
site of disposal while a 
reference to the applicable 
legislation is not necessary. 

 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 
 
134 

7.3.3.1 Acute Toxicity - Inhalation 

Hazard category 

Signal word   

Hazard statement 

1 

2 

Danger 

Danger 

H330  Fatal if inhaled 

H330  Fatal if inhaled 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P260 

Do not breathe 
dust/fume/gas/mist/vapours/ spray. 

Manufacturer/supplier to specify applicable 
conditions. 

  Highly recommended  

P271 

Use only outdoors or in a well-ventilated 
area. 

  Highly recommended for the general 

public 

  Optional for industrial/professional users 

Response 

P304 + P340 

Storage 

P403 + P233 

Disposal 

P501 

IF INHALED: Remove person to 
fresh air and keep at rest in a 
position comfortable for breathing. 

Store in a well-ventilated 
place. Keep container tightly 
closed. 

Dispose of 
contents/container to 
… 

  Highly recommended 

P310 

Immediately call a POISON 
CENTER/doctor/… 

- if product is volatile so as to 
generate hazardous atmosphere. 

  Highly recommended unless 
P404 has already been 
assigned  

… in accordance with 
local/regional/national/in
ternational regulations 
(to be specified). 

  Mandatory for the 

…Manufacturer/supplier to specify the 
appropriate source of emergency 
medical advice. 

P405 

Store locked up. 

  Highly recommended, in 

  Highly recommended for the 

combination with P304+P340 

general public 

P284 

P320 

Wear respiratory protection. 

Manufacturer/supplier to specify equipment.  

Specific treatment is urgent (see 
… on this label) 

  Optional for industrial / 

professional users unless other 
conditions deem it necessary 

general public if the 
substance / mixture 
is subject to 
legislation on 
hazardous waste. It 
is recommended to 
specify the site of 
disposal while a 
reference to the 
applicable legislation 
is not necessary. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
135 

  Recommended for industrial/professional 

users in exceptional cases where 
inadequate ventilation/organisational 
measures cannot sufficiently prevent 
inhalation  

  Recommended for inclusion in the safety 

data sheet 

… Reference to supplemental first aid 
instruction. 

- 

if immediate administration of 
antidote is required 

  Highly recommended only in 

exceptional cases where specific 
treatment is known and required 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

  Recommended for 

industrial / 
professional users if 
there are specific 
disposal 
requirements above 
the normal 
expectation for the 
disposal of 
chemicals. It is 
recommended to 
specify the site of 
disposal while a 
reference to the 
applicable legislation 
is not necessary. 

 
 
 
 
136 

7.3.3.1 Acute Toxicity – Inhalation 

Hazard category 

Signal word   

Hazard statement 

3 

Danger 

H331  Toxic if inhaled 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P261 

Avoid breathing 
dust/fume/gas/mist/ 
vapours/spray. 

Response 

P304 + P340 

Storage 

P403 + P233 

Disposal 

P501 

IF INHALED: Remove person to fresh air 
and keep comfortable for breathing. 

  Recommended 

Store in a well-ventilated 
place. Keep container tightly 
closed. 

Dispose of 
contents/container to 
… 

Manufacturer/supplier to specify 
applicable conditions. 

P311 

- if product is volatile so as to 
generate hazardous atmosphere. 

-  may be omitted if P260 is given on 

Call a POISON CENTER/doctor/... 

  Highly recommended 

the label. 

  Recommended  

P271 

Use only outdoors or in a well-
ventilated area. 

   Highly recommended for the 

general public 

  Optional for industrial/professional 

users 

…Manufacturer/supplier to specify the 
appropriate source of emergency medical 
advice. 

P405 

Store locked up. 

  Recommended, in combination with 

  Highly recommended for the 

P304+P340 

general public 

P321 

Specific treatment (see … on this label) 

… Reference to supplemental first aid 
instruction. 

- 

if immediate specific measures are 

  Optional for industrial / 

professional users unless 
other conditions deem it 
necessary 

… in accordance with 
local/regional/ 
national/international 
regulations (to be 
specified). 

  Mandatory for the 

general public if the 
substance / mixture 
is subject to 
legislation on 
hazardous waste. It 
is recommended to 
specify the site of 
disposal while a 
reference to the 
applicable legislation 
is not necessary. 

 
 
 
 
 
 
 
 
 
 
 
 
 
137 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

required. 

  Recommended for 

  Highly recommended only in exceptional 
cases where specific treatment is known 
and required 

industrial / 
professional users if 
there are specific 
disposal 
requirements above 
the normal 
expectation for the 
disposal of 
chemicals. It is 
recommended to 
specify the site of 
disposal while a 
reference to the 
applicable legislation 
is not necessary. 

 
 
 
 
138 

7.3.3.1 Acute Toxicity – Inhalation 

Hazard category 

Signal word   

Hazard statement 

4 

Warning 

H332  Harmful if inhaled 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Storage 

Disposal 

Precautionary Statements 

Prevention 

P261 

Avoid breathing 
dust/fume/gas/mist/ 
vapours/spray. 

Response 

P304 + P340 

IF INHALED: Remove person to 
fresh air and keep comfortable for 
breathing. 

Manufacturer/supplier to specify 
applicable conditions. 

-  may be omitted if P260 is given on 

  Optional 

P312 

the label. 

  Recommended  

P271 

Use only outdoors or in a well-
ventilated area. 

  Highly recommended for the general 

public 

  Optional for industrial/professional 

users  

Call a POISON CENTER or 
doctor/…/if you feel unwell. 

…Manufacturer/supplier to specify the 
appropriate source of emergency 
medical advice. 

  Recommended, unless P310, P311 

or P313 is assigned 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
139 

7.3.3.2 Skin corrosion/irritation 

Hazard category 

Signal word   

Hazard statement 

1A, 1B, 1C 

Danger 

H314  Causes severe skin burns and eye damage 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P260 

Do not breathe 
dust/fume/gas/mist/ 
vapours/spray. 

Manufacturer/supplier to specify 
applicable conditions. 

- specify do not breathe dusts or mists. 

- If inhalable particles of dusts or mists 
may occur during use. 

  Highly recommended  

Response 

P301 + P330 + P331 

Storage 

P405 

Disposal 

P501 

IF SWALLOWED: Rinse mouth. Do NOT 
induce vomiting. 

  Highly recommended for the general 
public, provided that medical advice 
indicates that the statement is 
appropriate 

  Recommended for industrial / 

professional users, provided that medical 
advice indicates that the statement is 
appropriate  

Store locked up. 

  Highly recommended for 

the general public 

  Optional for industrial / 

professional users unless 
other conditions deem it 
necessary 

P264 

P303 + P361 + P353 

Wash … thoroughly after handling. 

Manufacturer/supplier to specify parts 
of the body to be washed after 
handling. 

  Highly recommended for the general 
public, unless P280 has already 
been assigned 

IF ON SKIN (or hair): Take off 
immediately all contaminated clothing. 
Rinse skin with water/shower. 

  Highly recommended 

P363 

Wash contaminated clothing before 

Dispose of 
contents/container to … 

accordance 

…in 
local/regional/ 
national/international 
regulations (to be specified). 

with 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended 
to specify the site of 
disposal while a reference 
to the applicable legislation 
is not necessary. 

  Recommended for 

industrial / professional 
users if there are specific 
disposal requirements 
above the normal 
expectation for the 

 
 
 
 
 
 
 
 
 
 
 
 
Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

disposal of chemicals. It is 
recommended to specify 
the site of disposal while a 
reference to the applicable 
legislation is not 
necessary. 

140 

  Highly recommended for industrial / 
professional users, unless P280 has 
already been assigned  

P280 

Wear protective gloves/protective 
clothing/eye protection/face 
protection. 

Manufacturer/supplier to specify type of 
equipment.  

reuse. 

  Recommended for the general public 

  Recommended for inclusion in the safety 

data sheet 

P304 + P340 

If INHALED: Remove person to fresh air 
and keep comfortable for breathing. 

  Optional 

- Specify protective gloves/clothing and 
eye/face protection. 

P310 

  Highly recommended  

Immediately call a POISON 
CENTER/doctor/... 

…Manufacturer/supplier to specify the 
appropriate source of emergency medical 
advice. 

  Highly recommended, in combination 
with P303+P361+P353, P305+P351+ 
P338 or P301 + P330 + P331 

P321 

Specific treatment (see … on this label). 

…Reference to supplemental first aid 
instruction.  

- manufacturer/supplier may specify a 
cleansing agent if appropriate  

  Highly recommended only in exceptional 
cases where specific treatment is known 
and required 

 
 
 
 
 
 
141 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

P305 + P351 + P338 

IF IN EYES: Rinse cautiously with water 
for several minutes. Remove contact 
lenses, if present and easy to do. 
Continue rinsing. 

  Highly recommended 

 
 
 
 
Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

142 

7.3.3.2 Skin corrosion/irritation 

Hazard category 

Signal word   

Hazard statement 

2 

Warning 

H315  Causes skin irritation 

Precautionary Statements 

Prevention 

P264 

Wash … thoroughly after 
handling. 

… Manufacturer/supplier to specify 
parts of the body to be washed after 
handling. 

  Recommended 

P280 

Wear protective gloves/protective 
clothing/eye protection/face 
protection. 

Manufacturer/supplier to specify type 
of equipment.  

- Specify protective gloves. 

  Recommended 

Response 

P302 + P352 

Storage 

Disposal 

IF ON SKIN: Wash with plenty of water/... 

…Manufacturer/supplier may specify a cleansing agent if appropriate, or 
may recommend an alternative agent in exceptional cases if water is clearly 
inappropriate. 

  Optional for the general public 

  Recommended for inclusion in the safety data sheet 

P321 

Specific treatment (see … on this label). 

Reference to supplemental first aid instruction.  

-  manufacturer/supplier may specify a cleansing agent if appropriate  

  Recommended only in exceptional cases where specific treatment is 

known and required 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
143 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

P332 + P313 

If skin irritation occurs: Get medical advice/attention. 

  Optional 

  May be omitted when  P333 + P313 is assigned 

P362 + P364 

Take off contaminated clothing and wash it before reuse. 

  Optional 

  Recommended for inclusion in the safety data sheet 

 
 
 
 
 
 
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144 

7.3.3.3 Serious eye damage - only 

Hazard category 

Signal word   

Hazard statement 

1 

Danger 

H318  Causes serious eye damage 

Storage 

Disposal 

Precautionary Statements 

Prevention 

P280 

Response 

P305 + P351 + P338 

Wear protective gloves/protective 
clothing/eye protection/face 
protection. 

Manufacturer/supplier to specify type of 
equipment.  

IF IN EYES: Rinse cautiously with 
water for several minutes. Remove 
contact lenses, if present and easy to 
do. Continue rinsing. 

  Highly recommended 

- Specify eye/face protection. 

  Highly recommended  

P310 

Immediately call a POISON CENTER/ 
doctor/... 

…Manufacturer/supplier to specify the 
appropriate source of emergency medical 
advice. 

  Highly recommended, in combination 

with P305+P351+P338 

 
 
 
 
 
 
 
 
 
 
 
 
 
145 

7.3.3.3 Eye irritation – only  

Hazard category 

Signal word   

Hazard statement 

2 

Warning 

H319  Causes serious eye irritation 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Storage 

Disposal 

Precautionary Statements 

Prevention 

P280 

Response 

P305 + P351 + P338 

Wear protective gloves/protective 
clothing/eye protection/face 
protection. 

Manufacturer/supplier to specify type of 
equipment.  

IF IN EYES: Rinse cautiously with 
water for several minutes. Remove 
contact lenses, if present and easy to 
do. Continue rinsing. 

  Recommended for the general public 

- Specify eye/face protection. 

  Recommended for inclusion in the 

  Recommended  

P264 

safety data sheet 

P337 + P313 

Wash … thoroughly after handling. 

If eye irritation persists: Get medical 
advice/attention. 

… Manufacturer / supplier to specify parts 
of the body to be washed after handling. 

  Recommended 

  Optional for the industrial / 

professional users 

  Recommended for the general public 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
146 

7.3.3.4 Respiratory sensitisation 

Hazard category 

Signal word   

Hazard statement 

1, 1A, 1B 

Danger 

H334  May cause allergy or asthma symptoms or breathing  

difficulties if inhaled 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P261  

Avoid breathing 
dust/fume/gas/mist/ 
vapours/spray. 

Manufacturer/supplier to specify 
applicable conditions. 

Response 

P304 + P340 

Storage 

Disposal 

P501 

IF INHALED: Remove person to fresh 
air and keep comfortable for 
breathing. 

  Highly recommended 

-  may be omitted if P260 is given on 

P342 + P311 

the label. 

  Highly recommended 

If experiencing respiratory 
symptoms: Call a POISON CENTER or 
doctor / physician. 

P284 

  Highly recommended 

[In case of inadequate ventilation] 
wear respiratory protection. 

Manufacturer/supplier to specify 
equipment. 

- 

text in square brackets may be used if 
additional information is provided with 
the chemical at the point of use that 
explains what type of ventilation 

Dispose of 
contents/container to … 

… in accordance with 
local/regional/ 
national/international regulations 
(to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended to 
specify the site of disposal 
while a reference to the 
applicable legislation is not 
necessary. 

  Recommended for industrial 
/ professional users if there 
are specific disposal 
requirements above the 
normal expectation for the 

 
 
 
 
 
 
 
  
 
 
 
 
 
147 

would be adequate for safe use. 

  Recommended for 

industrial/professional users in 
exceptional cases where inadequate 
ventilation/organisational measures 
cannot sufficiently prevent inhalation 

  Recommended for inclusion in the 

safety data sheet  

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

disposal of chemicals. It is 
recommended to specify the 
site of disposal while a 
reference to the applicable 
legislation is not necessary. 

 
 
 
 
148 

7.3.3.4 Skin sensitisation 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Hazard category 

Signal word   

Hazard statement 

1, 1A, 1B 

Warning 

H317  May cause an allergic skin reaction 

Precautionary Statements 

Prevention 

P261  

Response 

P302 + P352 

Storage 

Disposal 

P501 

Avoid breathing dust/fume/gas/mist/ 
vapours/spray. 

IF ON SKIN: Wash with plenty of 
water/... 

Manufacturer/supplier to specify applicable 
conditions. 

-  may be omitted if P260 is given on the 

label. 

  Recommended  

P272 

…Manufacturer/supplier may specify a 
cleansing agent if appropriate, or may 
recommend an alternative agent in 
exceptional cases if water is clearly 
inappropriate. 

  Recommended for the general public 

  Recommended for inclusion in the safety 

Contaminated work clothing should not be 
allowed out of the workplace. 

data sheet 

P333 + P313 

  Not intended to be used for the general 

public 

If skin irritation or rash occurs: Get 
medical advice/attention. 

  Optional for industrial/professional users 

  Recommended 

P280 

P321 

Wear protective gloves/protective 
clothing/eye protection/face protection. 

Specific treatment (see … on this label) 

… Reference to supplemental first aid 

Dispose of 
contents/container to … 

… in accordance with 
local/regional/ 
national/international 
regulations (to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended 
to specify the site of 
disposal while a reference 
to the applicable legislation 
is not necessary. 

  Recommended for 

industrial / professional 
users if there are specific 
disposal requirements 
above the normal 
expectation for the 

 
 
 
 
 
 
 
 
 
 
 
149 

Manufacturer/supplier to specify type of 
equipment.  

- 

Specify protective gloves. 

  Highly recommended 

instruction. 

- manufacturer/supplier may specify a 
cleansing agent if appropriate. 

  Highly recommended only in exceptional 
cases where specific treatment is known 
and required 

P362+P364 

Take off contaminated clothing and 
wash it before reuse. 

  Recommended 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

disposal of chemicals. It is 
recommended to specify 
the site of disposal while a 
reference to the applicable 
legislation is not 
necessary. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

150 

7.3.3.5 Germ cell mutagenicity 

Hazard category 

Signal word   

Hazard statement 

1A and 1B 

Danger 
                                         conclusively proven that no other routes of exposure cause  
                                         the hazard) 

H340   May cause genetic defects (state route of exposure if it is  

2 

Warning 

H341   Suspected of causing genetic defects (state route of exposure  

                                                                        if it is conclusively proven that no other routes of exposure cause  
                                                                        the hazard) 

Precautionary Statements 

Prevention 

P201 

Response 

P308 + P313 

Storage 

P405 

Disposal 

P501 

Obtain special instructions before use. 

  Highly recommended for category 1A and 

1B 

  Recommended for category 2 

IF  exposed  or  concerned:  Get 
medical advice/attention. 

  Highly recommended for category 

1A and 1B 

  Recommended for category 2 

P202 

Do not handle until all safety precautions 
have been read and understood. 

  Optional where P201 is assigned 

Store locked up. 

  Highly recommended 

for the general public39 

  Optional for 

industrial/professional 
users unless other 
conditions deem it 
necessary 

Dispose 
contents/container to … 

of 

accordance 

… 
in 
local/regional/ 
national/international  regulations 
(to be specified). 

with 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended to 
specify the site of disposal 
while a reference to the 

39 Substances and mixtures which are listed in Appendix 1-6 of Annex XVII to Regulation (EC) No 1907/2006 (REACH) and which are assigned H340, 
H350 or H360 are restricted to industrial / professional users and normally not supplied to the general public (see entry 28, 29 and 30 in Annex XVII to 
REACH, as amended. The list of subsequent amendments of Annex XVII is accessible at http://echa.europa.eu/web/guest/regulations/reach/legislation. 

 
 
 
 
 
 
 
 
 
 
 
                                                 
151 

P280 

Wear protective gloves/protective 
clothing/eye protection/face protection. 

Manufacturer/supplier to specify type of 
equipment.  

- 

Specify protective gloves. 

  Highly recommended 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

applicable legislation is not 
necessary. 

  Recommended for industrial / 
professional users if there 
are specific disposal 
requirements above the 
normal expectation for the 
disposal of chemicals. It is 
recommended to specify the 
site of disposal while a 
reference to the applicable 
legislation is not necessary. 

 
 
 
 
 
 
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152 

7.3.3.6 Carcinogenicity 

Hazard category 

Signal word   

Hazard statement 

1A and 1B 

Danger 
                                         proven that no other routes of exposure cause the hazard) 

H350   May cause cancer (state route of exposure if it is conclusively 

2 

Warning 

H351   Suspected of causing cancer (state route of exposure if it is  

                                                              conclusively proven that no other routes of exposure cause the  
                                                              hazard) 

Precautionary Statements 

Prevention 

P201 

Response 

P308 + P313 

Storage 

P405 

Disposal 

P501 

Obtain special instructions before use. 

  Highly recommended for category 1A 

IF exposed or concerned: Get 
medical advice/attention. 

and 1B 

  Highly recommended for category 

1A and 1B 

  Recommended for category 2 

  Recommended for category 2 

P202 

Do not handle until all safety 
precautions have been read and 
understood. 

  Optional where P201 is assigned 

Store locked up. 

  Highly recommended 

for the general public40 

  Optional for 

industrial/professional 
users unless other 
conditions deem it 
necessary 

Dispose of contents/container 
to … 

… in accordance with 
local/regional/ 
national/international regulations 
(to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended to 
specify the site of disposal 
while a reference to the 
applicable legislation is not 

40  Substances  and mixtures which  are  listed in  Appendix  1-6  of Annex XVII  to Regulation (EC) No  1907/2006 (REACH) and which are  assigned H340, 
H350 or H360 are restricted to industrial / professional users and normally not supplied to the general public (see entry 28, 29 and 30 in Annex XVII to 
REACH as amended. The list of subsequent amendments of Annex XVII is accessible at: http://echa.europa.eu/web/guest/regulations/reach/legislation. 

 
 
 
 
 
 
 
 
 
 
                                                 
153 

P280 

Wear protective gloves/protective 
clothing/eye protection/face 
protection. 

Manufacturer/supplier to specify type of 
equipment.  

- 

Specify protective gloves. 

  Highly recommended 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

necessary. 

  Recommended for industrial / 
professional users if there are 
specific disposal requirements 
above the normal expectation 
for the disposal of chemicals. 
It is recommended to specify 
the site of disposal while a 
reference to the applicable 
legislation is not necessary. 

 
 
 
 
 
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154 

7.3.3.7 Reproductive toxicity 

Hazard category 

Signal word   

Hazard statement 

1A and 1B 

Danger 
                                         (state specific effect if known)  

H360   May damage fertility or the unborn child  

(state route of exposure if it is conclusively proven  
 that no other routes of exposure cause the hazard) 

2 

Warning 
                                         (state specific effect if known)  

H361   Suspected of damaging fertility or the unborn child  

(state route of exposure if it is conclusively proven that  
no other routes of exposure cause the hazard) 

Precautionary Statements 

Prevention 

P201 

Response 

P308 + P313 

Storage 

P405 

Disposal 

P501 

Obtain special instructions before use. 

  Highly recommended for category 1A and 

1B 

  Recommended for category 2 

IF exposed or concerned: Get 
medical advice/attention. 

  Highly recommended for 
category 1A and 1B 

  Recommended for category 2 

P202 

Do not handle until all safety precautions 
have been read and understood. 

Store locked up. 

  Highly recommended for 
the general public41 

  Optional for industrial / 

professional users unless 
other conditions deem it 
necessary 

Dispose of contents/container 
to … 

… in accordance with 
local/regional/ 
national/international regulations 
(to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 

41 Substances and mixtures which are listed in Appendix 1-6 of Annex XVII to Regulation (EC) No 1907/2006 (REACH) and which are assigned H340, 
H350 or H360 are restricted to industrial / professional users and normally not supplied to the general public (see entry 28, 29 and 30 in Annex XVII to 
REACH as amended. The list of subsequent amendments of Annex XVII is accessible at ECHA website: 
http://echa.europa.eu/web/guest/regulations/reach/legislation). 

 
 
 
 
 
 
                                
                                
 
                                
                                
                                                 
155 

  Optional where P201 is assigned 

P280 

Wear protective gloves/protective 
clothing/eye protection/face protection. 

Manufacturer/supplier to specify type of 
equipment.  

- 

Specify protective gloves. 

  Highly recommended 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

waste. It is recommended to 
specify the site of disposal 
while a reference to the 
applicable legislation is not 
necessary. 

  Recommended for industrial / 
professional users if there are 
specific disposal requirements 
above the normal expectation 
for the disposal of chemicals. 
It is recommended to specify 
the site of disposal while a 
reference to the applicable 
legislation is not necessary. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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156 

7.3.3.7 Reproductive toxicity 

Hazard category 

Signal word   

Hazard statement   

Additional category for effects on  
or via lactation 

No signal word 

H362   May cause harm to breast-fed children 

Precautionary Statements 

Prevention 

P201 

Response 

P308 + P313 

Obtain special instructions before 
use. 

IF exposed or concerned: Get medical 
advice/attention. 

  Highly recommended  

  Recommended 

Storage 

Disposal 

No hazard 
pictogram 

P260 

Do not breathe dust/fume/gas/mist/ 
vapours/spray. 

Manufacturer/supplier to specify 
applicable conditions. 

- 

- 

specify do not breathe dusts or mists. 

If inhalable particles of dusts or mists 
may occur during use. 

  Highly recommended   

P263 

Avoid contact during 
pregnancy/while nursing. 

  Highly recommended 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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157 

P264 

Wash … thoroughly after handling. 

… Manufacturer / supplier to specify parts 
of the body to be washed after handling. 

  Optional 

P270 

Do not eat, drink or smoke when 
using this product. 

  Recommended for the general public 

  Optional for industrial / professional 

users 

  Recommended for inclusion in the 

safety data sheet 

 
 
 
 
 
 
 
 
 
 
 
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7.3.3.8 Specific target organ toxicity after single exposure 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Hazard category 

Signal word   

Hazard statement 

1 

Danger 
                                         (state route of exposure if it is conclusively proven that no 

H370   Causes damage to organs (or state all organs affected, if known)  

                                                                                  other routes of exposure cause the hazard) 

Precautionary Statements 

Prevention 

P260 

Response 

P308 + P311 

Storage 

P405 

Disposal 

P501 

Do not breathe dust/fume/gas/mist/ 
vapours/spray. 

IF exposed or concerned: Call a 
POISON CENTER/doctor… 

Manufacturer/supplier to specify 
applicable conditions. 

  Highly recommended where the 

substance / mixture is volatile or a 
gas or where exposure via inhalation 
is possible, e.g. through spraying or 
inhalable dust or in case H370 
indicates inhalation as a route of 
exposure 

P264 

Wash … thoroughly after handling. 

Manufacturer/supplier to specify the 
appropriate source of emergency 
medical advice. 

  Highly recommended 

P321 

Specific treatment (see … on this 
label) 

… Reference to supplemental first aid 
instruction. 

… Manufacturer / supplier to specify parts 

- if immediate measures are required. 

Store locked up. 

  Highly recommended 
for the general public 

  Optional for industrial / 
professional users 
unless other conditions 
deem it necessary 

Dispose of contents/container to 
… 

… in accordance with local/regional/ 
national/international regulations (to 
be specified). 

  Mandatory for the general public 
if the substance / mixture is 
subject to legislation on 
hazardous waste. It is 
recommended to specify the site 
of disposal while a reference to 
the applicable legislation is not 
necessary. 

  Recommended for industrial / 
professional users if there are 
specific disposal requirements 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
159 

of the body to be washed after handling. 

  Highly recommended only in 

exceptional cases where specific 
treatment is known and required 

  Optional 

P270 

Do not eat, drink or smoke when 
using this product. 

  Recommended for the general public 

  Optional for industrial / professional 

users 

  Recommended for inclusion in the 

safety data sheet 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

above the normal expectation 
for the disposal of chemicals. It 
is recommended to specify the 
site of disposal while a reference 
to the applicable legislation is 
not necessary. 

 
 
 
 
160 

7.3.3.8 Specific target organ toxicity after single exposure 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Hazard category 

Signal word   

Hazard statement 

2                                        Warning                  H371   May cause damage to organs (or state all organs affected, if known) 

(state route of exposure if it is conclusively proven that no other routes of 
exposure cause the hazard) 

Precautionary Statements 

Prevention 

P260 

Response 

P308 + P311 

Storage 

P405 

Disposal 

P501 

Do not breathe dust/fume/gas/mist/ 
vapours/spray. 

IF exposed or concerned: Call a 
POISON CENTER/ doctor/... 

Manufacturer/supplier to specify the 
appropriate source of emergency 
medical advice 

  Recommended 

Manufacturer/supplier to specify 
applicable conditions. 

  Highly recommended where the 

substance / mixture is volatile or a 
gas or where exposure via inhalation 
is possible, e.g. through spraying or 
inhalable dust or in case H371 
indicates inhalation as a route of 
exposure 

P264 

Wash … thoroughly after handling. 

… Manufacturer / supplier to specify parts 
of the body to be washed after handling. 

Store locked up. 

  Highly recommended for 

the general public 

  Optional for industrial / 

professional users unless 
other conditions deem it 
necessary 

Dispose of contents/container 
to … 

… in accordance with 
local/regional/ 
national/international regulations 
(to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended to 
specify the site of disposal 
while a reference to the 
applicable legislation is not 
necessary. 

  Recommended for industrial / 

 
 
 
 
 
 
 
 
  
161 

  Optional 

P270 

Do not eat, drink or smoke when 
using this product. 

  Recommended for the general public 

  Optional for industrial / professional 

users 

  Recommended for inclusion in the 

safety data sheet 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

professional users if there are 
specific disposal requirements 
above the normal expectation 
for the disposal of chemicals. 
It is recommended to specify 
the site of disposal while a 
reference to the applicable 
legislation is not necessary. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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7.3.3.8 Specific target organ toxicity after single exposure 

Hazard category 

Signal word   

Hazard statement 

3                                        Warning 

          H335  May cause respiratory irritation; or 
H336  May cause drowsiness or dizziness 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P261 

Avoid breathing 
dust/fume/gas/mist/ 
vapours/spray. 

Response 

P304 + P340 

Storage 

P403 + P233 

Disposal 

P501 

IF INHALED: Remove person to 
fresh air and keep comfortable 
for breathing. 

Store in a well-ventilated 
place. Keep container tightly 
closed. 

Manufacturer/supplier to specify 
applicable conditions. 

- may be omitted if P260 is given on the 

  Optional 

P312 

label. 

  Recommended  

P271 

Use only outdoors or in a well-
ventilated area. 

Call a POISON 
CENTER/doctor/…/ if you feel 
unwell. 

…Manufacturer/supplier to specify 
the appropriate source of emergency 
medical advice. 

  Highly recommended for the general 

public 

  Recommended unless P310, 
P311 or P313 is assigned 

  Optional for industrial / professional 

users 

- if product is volatile so as to 
generate hazardous 
atmosphere. 

Dispose of 
contents/container to … 

… in accordance with 
local/regional/ 
national/international regulations 
(to be specified). 

  Recommended unless P404 

  Mandatory for the general 

is assigned 

P405 

Store locked up. 

  Highly recommended for the 

general public 

  Optional for industrial / 

professional users unless 
other conditions deem it 
necessary 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended to 
specify the site of disposal 
while a reference to the 
applicable legislation is not 
necessary. 

  Recommended for industrial 
/ professional users if there 
are specific disposal 
requirements above the 
normal expectation for the 

 
 
 
 
 
 
 
 
 
 
 
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disposal of chemicals. It is 
recommended to specify the 
site of disposal while a 
reference to the applicable 
legislation is not necessary. 

 
 
 
 
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7.3.3.9 Specific target organ toxicity after repeated exposure 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Hazard category 

Signal word   

Hazard statement 

1                                       Danger                     H372   Causes damage to organs (state all organs affected, if known)                                                                                 

through prolonged or repeated exposure (state route of exposure if it is 
conclusively proven that no other routes of exposure cause the hazard) 

Precautionary Statements 

Prevention 

P260 

Response 

P314 

Storage 

Disposal 

P501 

Do not breathe dust/fume/gas/mist/ 
vapours/spray. 

Get medical advice/attention if 
you feel unwell. 

Manufacturer/supplier to specify applicable 
conditions. 

  Recommended unless P310, P311, 

P312 or P313 is assigned 

  Highly recommended where the 

substance / mixture is volatile or a gas or 
where exposure via inhalation is possible, 
e.g. through spraying or inhalable dust or 
in case H372 indicates inhalation as a 
route of exposure 

P264 

Wash … thoroughly after handling. 

… Manufacturer / supplier to specify parts of 
the body to be washed after handling. 

Dispose of contents/container 
to … 

… in accordance with 
local/regional/ 
national/international regulations 
(to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended to 
specify the site of disposal 
while a reference to the 
applicable legislation is not 
necessary. 

  Recommended for industrial / 
professional users if there are 

 
 
 
 
 
 
 
 
 
165 

  Optional 

P270 

Do not eat, drink or smoke when using 
this product. 

  Recommended for the general public 

  Optional for industrial / professional users 

  Recommended for inclusion in the safety 

data sheet 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

specific disposal requirements 
above the normal expectation 
for the disposal of chemicals. 
It is recommended to specify 
the site of disposal while a 
reference to the applicable 
legislation is not necessary. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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7.3.3.9 Specific target organ toxicity after repeated exposure 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Hazard category 

Signal word   

Hazard statement 

2                                       Warning                   H373   May cause damage to organs (state all organs affected, if 

known) through prolonged or repeated exposure (state route of  
exposure if it is conclusively proven that no other routes of exposure  
cause the hazard) 

Precautionary Statements 

Prevention 

P260 

Response 

P314 

Storage 

Disposal 

P501 

Do not breathe 
dust/fume/gas/mist/vapours/spray. 

Get medical advice/attention if you 
feel unwell. 

Manufacturer/supplier to specify 
applicable conditions. 

  Recommended unless P310, P311, 

P312 or P313 is assigned 

  Highly recommended where the 

substance / mixture is highly volatile 
or a gas or where exposure via 
inhalation is possible, e.g. through 
spraying or inhalable dust or in case 
H373 indicates inhalation as a route 
of exposure 

Dispose of contents/container 
to … 

… in accordance with 
local/regional/ 
national/international regulations 
(to be specified). 

  Mandatory for the general 

public if the substance / 
mixture is subject to 
legislation on hazardous 
waste. It is recommended to 
specify the site of disposal 
while a reference to the 
applicable legislation is not 
necessary. 

  Recommended for industrial / 
professional users if there are 

 
 
 
 
 
 
 
 
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Guidance on Labelling and Packaging 

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specific disposal requirements 
above the normal expectation 
for the disposal of chemicals. 
It is recommended to specify 
the site of disposal while a 
reference to the applicable 
legislation is not necessary. 

 
 
 
 
168 

7.3.3.10 Aspiration hazard 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Hazard category 

Signal word   

Hazard statement 

1 

Danger 

H304  May be fatal if swallowed and enters airways 

Precautionary Statements 

Prevention 

Response 

P301 + P310 

Storage 

P405 

Disposal 

P501 

IF SWALLOWED: Immediately call 
a POISON CENTER/ doctor/... 

…Manufacturer/supplier to specify the 
appropriate source of emergency 
medical advice. 

  Highly recommended, in 

combination with P331 

P331 

Do NOT induce vomiting. 

  Highly recommended, in 

combination with P301 +P310 

Store locked up. 

Dispose of contents/container to … 

  Highly recommended for the 

general public 

  Optional for industrial / 

professional users unless other 
conditions deem it necessary 

… in accordance with local/regional/ 
national/international regulations (to be 
specified). 

  Mandatory for the general public if 

the substance / mixture is subject to 
legislation on hazardous waste. It is 
recommended to specify the site of 
disposal while a reference to the 
applicable legislation is not 
necessary. 

  Recommended for industrial / 
professional users if there are 
specific disposal requirements above 
the normal expectation for the 
disposal of chemicals. It is 
recommended to specify the site of 
disposal while a reference to the 
applicable legislation is not 
necessary. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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7.3.4 Specific precautionary statements for environmental hazards 

7.3.4.1 Hazardous to the aquatic environment – Acute hazard 

Hazard category 

Signal word   

Hazard statement 

1 

Warning 

H400  Very toxic to aquatic life 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P273 

Response 

P391 

Avoid release to the environment. 

Collect spillage. 

-  if this is not the intended use. 

  Recommended 

  Recommended 

Storage 

Disposal 

P501 

Dispose of contents/container to … 

… in accordance with local/regional/ 
national/international regulations (to be 
specified). 

  Mandatory for the general public if the 
substance / mixture is subject to 
legislation on hazardous waste. It is 
recommended to specify the site of 
disposal while a reference to the 
applicable legislation is not necessary. 

  Recommended for industrial / 

professional users if there are specific 
disposal requirements above the 
normal expectation for the disposal of 
chemicals. It is recommended to 
specify the site of disposal while a 
reference to the applicable legislation 
is not necessary. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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7.3.4.1 Hazardous to the aquatic environment – Chronic hazard 

Hazard category 

Signal word   

Hazard statement 

1 

2 

Warning 

H410  Very toxic to aquatic life with long lasting effects 

No signal word 

H411  Toxic to aquatic life with long lasting effects 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P273 

Response 

P391 

Avoid release to the environment. 

Collect spillage. 

-  if this is not the intended use. 

  Recommended 

  Recommended 

Storage 

Disposal 

P501 

Dispose of contents/container to … 

… in accordance with local/regional/ 
national/international regulations (to be 
specified). 

  Mandatory for the general public if the 
substance / mixture is subject to 
legislation on hazardous waste. It is 
recommended to specify the site of 
disposal while a reference to the 
applicable legislation is not necessary. 

  Recommended for industrial / professional 

users if there are specific disposal 
requirements above the normal 
expectation for the disposal of chemicals. 
It is recommended to specify the site of 
disposal while a reference to the 
applicable legislation is not necessary. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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7.3.4.1 Hazardous to the aquatic environment – Chronic hazard 

Hazard category 

Signal word   

Hazard statement 

3 

4 

No signal word 

No signal word 

H412  Harmful to aquatic life with long lasting effects 

H413  May cause long lasting harmful effects to aquatic life 

Guidance on Labelling and Packaging 

Version 2.0 - September 2016 

Precautionary Statements 

Prevention 

P273 

Avoid release to the environment. 

-  if this is not the intended use. 

  Recommended  

Response 

Storage 

Disposal 

P501 

Dispose of contents/container to … 

… in accordance with local/regional/ 
national/international regulations (to be 
specified). 

  Mandatory for the general public if the 
substance / mixture is subject to 
legislation on hazardous waste. It is 
recommended to specify the site of 
disposal while a reference to the 
applicable legislation is not necessary. 

  Recommended for industrial / 

professional users if there are specific 
disposal requirements above the 
normal expectation for the disposal of 
chemicals. It is recommended to 
specify the site of disposal while a 
reference to the applicable legislation 
is not necessary. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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172 

7.3.5 Additional hazards 

7.3.5.1 Hazardous to the ozone layer  

Hazard category 

Signal word   

Hazard statement 

1 

Warning 

H420  Harms public health and the environment by destroying ozone  

in the upper atmosphere 

Precautionary Statements 

Prevention 

Response 

Storage 

Disposal 

P502 

Dispose of contents/container to … 

Refer to manufacturer/supplier for 
information on recovery / recycling 

  Mandatory for the general public 

  Highly recommended  for industrial 

/ professional users 

 
 
 
 
 
 
 
 
 
             
 
 
 
 
 
 
 
 
 
 
 
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7.4. Examples for the selection of precautionary statements for the 
label 

This section provides practical examples on how to select precautionary statements for 
various model substances. The set of precautionary statements to be prioritised for the label 
is highlighted in bold underlined (highly recommended) and underlined 
(recommended), while the optional statements appear in normal letters (no highlighting) 
and the statements not to be used/unless condition applies/ inclusion on safety data sheet only 
are marked in grey colour.  

Please note that even if a substance or mixture has the same hazards as one of the 
following examples, another set of precautionary statements might be appropriate based on 
the specific conditions for use given in the tables above. 

Example A. Substance X assigned a physical and various health hazard 
classifications 

A. Classification and hazard statements: 

Flam. Liq. 2 

H225  Highly flammable liquid and vapour 

Acute Tox. 3 (oral) 

H301  Toxic if swallowed 

Acute Tox. 3 (dermal) 

H311  Toxic in contact with skin 

Acute Tox. 3 (inhalation) 

H331  Toxic if inhaled 

STOT-SE 1                            H370  Causes damage to liver through dermal exposure 

B. Further information: 

Substance X is presumed to be volatile, but not so as to generate a potentially explosive 
atmosphere. There is possible exposure via inhalation. Specific extinction media are not 
necessary. Specific treatment/measures is/are not urgently required. No specific disposal 
precautionary statements are required since the substance is not intended to be used by the 
general public, but only by industrial/professional users. 

C. Precautionary statements on the basis of the classification (see Annex I and IV to CLP) 
and according to the guidance: 

Acute Tox.  3 
(Oral) 

Acute Tox. 3 
(Dermal) 

Acute Tox. 3 
(Inhalation) 

STOT-SE 1 

Flam. Liq. 2 

P264 

P270 

P280 

P261 

P271 

P260 

P264 

P270 

P210 

P233 

P240 

P241 

P242 

P243 

P280 

 
 
 
 
 
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P304 + P340 

P308 + P311 

P303 + P361 + P353 

P311 

P321 

P321 

P370 + P378 

174 

P301 + P310 

P321 

P330 

P312 

P321 

P361 + P364 

P363 

P302 + P352 

P405 

P405 

P403 + P233 

P405 

P403 + P235 

P501 

P501 

P405 

P501 

P501 

P501 

Explanation on use of bolding, underline and grey marker:  

PXXX  = highly recommended;  
PXXX    = recommended;  

PXXX   = optional;   

PXXX   = not to be used/unless condition applies/inclusion on safety data sheet only 

D. Selection of highly recommended and recommended precautionary statements: 

Where the same statement is assigned to different hazards, but with different priority, the 
most conservative approach is taken. Where appropriate, precautionary statements are 
combined into a single combination statement. Duplication of individual phrases is avoided. 
The selection results in the following set of P-statements: 

P210  

Keep away from heat, hot surfaces, sparks, open flames and 
other ignition sources. No smoking. 

P260                       Do not breathe dust/fume/gas/mist/vapours/spray. 

P280    

Wear protective gloves/protective clothing/eye protection/face 
protection. 

P301+P310            IF SWALLOWED: Immediately call a POISON CENTER/doctor/… 

P308+P311            IF exposed or concerned: Call a POISON CENTER/doctor/... 

P304+P340              IF INHALED: Remove person to fresh air and keep comfortable for 

breathing. 

P403+P233     

Store in a well-ventilated place. Keep container tightly closed.  

E. Result: 

Selection in line with the guidance results in seven precautionary statements. A 
substantial reduction is achieved compared to the starting set of potentially 
applicable statements for the CLP hazard label, assignable on the basis of the 
underlying hazards.  

 
 
 
 
 
 
 
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The selected precautionary statements must be placed on the CLP hazard label. As an SDS 
needs to be prepared, the statements would also have to be included in the SDS, under 
heading 2.2 (“Label elements”), see the Guidance on the compilation of safety data sheets. 
The de-selected statements can be introduced under the relevant headings of the SDS to 
provide the industrial or professional user with sufficient information to handle the 
substance safely. 

Example B. Sodium peroxide Na2O2, (EC: 215-209-4) assigned a severe 
physical and health hazard classification 

A. Classification and hazard statements: 

Ox. Sol. 1 

H271   May cause fire or explosion; strong oxidiser 

Skin Corr. 1A   

H314   Causes severe skin burns and eye damage 

B. Further information: 

Sodium peroxide is a granular solid and is presumed to be non-volatile. Dust exposure 
during handling and use is possible. Specific extinction media are not necessary. Specific 
treatment/measures is/are not urgently required. No specific disposal precautionary 
statements are required since the substance is not intended to be used by the general 
public, but only by industrial/professional users. 

C. Precautionary statements on the basis of the classification (see Annex I and IV to CLP) 
and according to the guidance: 

Ox. Sol. 1 

Skin Corr. 1A 

P210 

P220 

P221 

P280 

P283 

P260 

P264 

P280 

P301+P330+P331 

P303+P361+P353 

P306+P360 

P363 

P371+P380+P375 

P304+P340 

P370+P378 

- 

P501 

P310 

P321 

P305+P351+P338 

P405 

P501 

 
 
 
 
 
 
 
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D. Selection of highly recommended and recommended precautionary statements: 

Where the same statement is assigned to different hazards, but with different priority, the 
most conservative approach is taken (i.e. the highest priority must be taken into account). 
Where appropriate, precautionary statements are combined into a single combination 
statement. Duplication of individual phrases is avoided. The selection results in the following 
set of P-statements: 

P210  

Keep away from heat, hot surfaces, sparks, open 
flames and other ignition sources. No smoking. 

P221                        

Take any precaution to avoid mixing with combustibles. 

P260 

P280   

Do not breathe dust/fume/gas/mist/vapours/spray. 

Wear protective gloves/protective clothing/eye 
protection/ face protection. 

P301+P330+P331    

IF SWALLOWED: rinse mouth. Do NOT induce vomiting. 

P303+P361+P353+310     IF ON SKIN (or hair): Take off immediately all 

P305+P351+P338    

contaminated clothing. Rinse skin with water/shower. 
Immediately call a POISON CENTER/doctor/... 

IF IN EYES: Rinse cautiously with water for several 
minutes. Remove contact lenses, if present and easy to 
do. Continue rinsing. 

P371+P380+P375     

In case of major fire and large quantities: Evacuate 
area. Fight fire remotely due to the risk of explosion. 

E. Result: 

Selection in line with the guidance results in eight, mostly combined, 
precautionary statements. A substantial reduction is achieved compared to the 
starting set of potentially applicable statements for the CLP hazard label, 
assignable on the basis of the underlying hazards. 

The selected precautionary statements must be placed on the CLP hazard label. As an SDS 
needs to be prepared, they would also have to be included in the SDS, under heading 2.2 
(“Label elements”), see the Guidance on the compilation of safety data sheets.  

The de-selected statements can be introduced under the relevant headings of the SDS to 
provide the industrial or professional user with sufficient information to handle the 
substance safely. 

 
 
 
 
 
 
 
 
 
 
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Example C. Dimethylzinc (EC: 208-884-1) assigned physical, health and 
environmental classifications 

A. Classification and hazard statements: 

Pyr. Liq. 1 

H250  Catches fire spontaneously if exposed to air 

Water-react. 1       H260  In contact with water releases flammable gases which may  

ignite spontaneously 

Skin Corr. 1B   

H314  Causes severe skin burns and eye damage 

Aquatic Acute 1 

H400  Very toxic to aquatic life (redundant because of H410) 

Aquatic Chronic 1 

H410  Very toxic to aquatic life with long lasting effects 

B. Further information: 

Dimethylzinc should be regarded as volatile. Therefore, there is possible exposure via 
inhalation. Specific extinction media are necessary, because water will increase the risk 
when used for the extinction of fire. As the disposal of the packaging presents a hazard to 
human health or the environment, specific disposal precautionary statements are required 
(although the substance is not intended to be used by the general public, but only by 
industrial/professional users). 

C. Precautionary statements on the basis of the classification (see Annex I and IV to CLP) 
and according to the guidance: 

Pyr. Liq.1  Water-react. 1 

Skin Corr. 1B 

P210 

P222 

P280 

P231(add) 

P223 

P231+P232 

P280 

P260 

P264 

P280 

Aquatic 
Acute 1 

P273 

Aquatic 
Chronic 1 

P273 

P301+P330+P331 

P391 

P391 

P303+P361+P353 

P302+P334 

P335+P334 

P370+P378 

P370+P378 

P363 

P304+P340 

P310 

P321 

P305+P351+P338 

P422 

P402+P404 

- 

P501 

P405 

P501 

- 

- 

P501 

P501 

 
 
 
 
 
 
 
 
 
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D. Selection of highly recommended and recommended precautionary statements: 

Where the same statement is assigned to different hazards, but with different priority, the 
most conservative approach is taken (i.e. the highest priority must be taken into account). 
Where appropriate, precautionary statements are combined into a single combination 
statement. Duplication of individual phrases is avoided. 

P303+ P361+P353   

IF ON SKIN (or hair): Take off immediately all contaminated 
clothing. Rinse skin with water/shower.  

         and  

P302+P335+P334+P310  

IF ON SKIN: Brush off loose particles from skin. Immerse in 
cool water.42 Immediately call a POISON CENTER/doctor/…)  

         were merged into one single combination phrase: 

P303+ P335+P334+P310+P361 where duplication of the message was avoided.  

The selection results in the following set of P-statements: 

P210  

P260 

P273 

P280    

P231+P232              

P301+P330+P331      

P303+ P335+P334+P310+P361 

P305+P351+P338    

Keep away from heat, hot surfaces, sparks, 
open flames and other ignition sources. No 
smoking. 

Do not breathe dust/fume/gas/mist/ 
vapours/spray. 

Avoid release to the environment. 

Wear protective gloves/protective 
clothing/eye protection/face protection. 

Handle under inert gas. Protect from 
moisture. 

IF SWALLOWED: rinse mouth. Do NOT induce 
vomiting. 

IF ON SKIN (or hair): Brush off loose 
particles from skin. Immerse in cool 
water.43 Immediately call a POISON 
CENTER/doctor/… Remove/Take off 
immediately all contaminated clothing. 

IF IN EYES: Rinse cautiously with water for 
several minutes. Remove contact lenses, if 
present and easy to do. Continue rinsing. 

P370+P378 

In case of fire: Use … to extinguish. 

42  The  sub-phrase  of  P334  “/wrap  in  wet  bandages”  is  not  to be  used  for  water-reactive  substances 
and mixtures category 1 (Table 7.3.2.12 in sub-section 7.3 of this guidance). 

43  The  sub-phrase  of  P334  “/wrap  in  wet  bandages”  is  not  to be  used  for  water-reactive  substances 
and mixtures category 1 (Table 7.3.2.12 in sub-section 7.3 of this guidance). 

 
 
 
 
 
 
 
                      
 
 
 
 
 
 
 
                                                 
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179 

E. Result: 

Selection in line with the guidance results in nine, partly combined, precautionary 
statements.  

A substantial reduction is achieved compared to the starting set of potentially 
applicable statements for the CLP hazard label, assignable on the basis of the 
underlying hazards. For example, P264 has not been selected, because P280 is 
more relevant. 

To further reduce the number of the P-statements and the amount of digestible 
information on the label, the statements P391 and P501 have been put in the SDS, 
as the prevention and response statements for the physical and health hazards 
appear to contain the more urgent advice for the label.  

The selected precautionary statements must be placed on the CLP hazard label. As an SDS 
needs to be prepared, they would also have to be included in the SDS, under heading 2.2 
(“Label elements”), see the Guidance on the compilation of safety data sheets.  

The de-selected statements can be introduced under the relevant headings of the SDS to 
provide the industrial or professional user with sufficient information to handle the 
substance safely. 

Example D. Mixture ABC for use by the general public 

A. Classification and hazard statements: 

Flam. Liq. 2 

H225  Highly flammable liquid and vapour 

Acute Tox. 4 (oral) 

H302  Harmful if swallowed 

Skin irrit. 2 

H315  Causes skin irritation 

B. Further information: 

Mixture ABC is presumed to be volatile, but not so as to generate a potentially explosive 
atmosphere. Specific extinction media are not necessary. Specific treatment is not urgently 
required. There are no specific disposal requirements. The mixture is intended to be used by 
the general public. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
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C. Precautionary statements on the basis of the classification (see Annex I and IV to CLP) 
and according to the guidance: 

Flam. Liq. 2 

Acute Tox.  4 (Oral)  Skin Irrit. 2 

P101, P102 

P264 

P270 

P264 

P280 

P210 

P233 

P240 

P241 

P242 

P243 

P280 

P303 + P361 + P353 

P301+P312 

P302+P352 

P370 + P378 

P330 

P403 + P235 

P501 

- 

P501 

P321 

P332+P313 

P362 

- 

- 

D. Selection of highly recommended and recommended precautionary statements: 

Where the same statement is assigned to different hazards, but with different priority, the 
most conservative approach is taken. Where appropriate, precautionary statements are 
combined into a single combination statement. Duplication of individual phrases is avoided. 
The selection results in the following set of P-statements: 

P101  If medical advice is needed, have product container or label at hand. 

P102  Keep out of reach of children. 

P210  Keep away from heat, hot surfaces, sparks, open flames and other ignition 

sources. No smoking. 

P233  Keep container tightly closed. 

P264  Wash … thoroughly after handling. 

P270  Do not eat, drink or smoke when using this product. 

P280   Wear protective gloves. 

 
 
 
 
 
 
 
 
 
 
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E. Result: 

Selection in line with the guidance results in seven precautionary statements. A 
substantial reduction is achieved compared to the starting set of potentially 
applicable statements for the CLP hazard label, assignable on the basis of the 
underlying hazards. 

The selected precautionary statements must be placed on the CLP hazard label. As an SDS 
needs to be prepared, they would also have to be included in the SDS, under heading 2.2 
(“Label elements”), see the Guidance on the compilation of safety data sheets.  

The de-selected statements can be introduced under the relevant headings of the SDS to 
provide the industrial or professional user with sufficient information to handle the 
substance safely.   

 
 
 
 
 
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Appendix: Glossary of selected terms used in this guidance 

ADR  

Acute toxicity  

Aerosols  

Alloy  

Article  

Aspiration  

BPR 

Carcinogen  

CAS    

the European Agreement concerning the 
International Carriage of Dangerous Goods by 
Road (concluded in Geneva on 30 September 
1957) that has been implemented within the EU 
through Directive 2008/68/EC; 

those adverse effects occurring following oral or 
dermal administration of a single dose of a 
substance or a mixture, or multiple doses given 
within 24 hours, or an inhalation exposure of 4 
hours; 

this means aerosol dispensers, are any non-
refillable receptacles made of metal, glass or 
plastics and containing a gas compressed, 
liquefied or dissolved under pressure, with or 
without a liquid, paste or powder, and fitted with 
a release device allowing the contents to be 
ejected as solid or liquid particles in suspension 
in a gas, as a foam, paste or powder or in a liquid 
state or in a gaseous state; 

a metallic material, homogeneous on a 
macroscopic scale, consisting of two or more 
elements so combined that they cannot be 
readily separated by mechanical means; alloys 
are considered to be mixtures for the purposes of 
CLP; 

an object which during production is given a 
special shape, surface or design which 
determines its function to a greater degree than 
does its chemical composition; 

the entry of a liquid or solid substance or mixture 
directly through the oral or nasal cavity, or 
indirectly from vomiting, into the trachea and 
lower respiratory system; 

Regulation (EU) No 528/2012 of the European 
Parliament and of the Council of 22 May 2012 
concerning the making available on the market 
and use of biocidal products (Biocidal Products 
Regulation); 

a substance or a mixture of substances which 
induces cancer or increases its incidence; 

Chemical Abstract Service; 

 
 
 
 
 
 
 
 
 
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Chemically unstable gas 

CLP or CLP Regulation  

CMR  

Competent authority (CA)  

Corrosive to metals  

CRC  

CRF  

Distributor  

Downstream user  

DPD  

DSD  

ECHA  

EU  

Explosive article  

Explosive substance or mixture  

Guidance on Labelling and Packaging 

Version 2.0 – September 2016 

a flammable gas that is able to react explosively 
even in the absence of air or oxygen; 

Regulation (EC) No 1272/2008 on Classification, 
Labelling and Packaging of Substances and 
Mixtures; 

a substance or mixture which is carcinogenic, 
mutagenic or toxic to reproduction; 

the  authority  or  authorities  or  bodies  established 
by the member states to carry out the obligations 
arising from the CLP Regulation; 

a substance or a mixture which by chemical 
action will materially damage, or even destroy, 
metals; 

child-resistant closure; 

child-resistant fastening; 

any natural or legal person established within the 
Community, including a retailer, who only stores 
and places on the market a substance, on its own 
or in a mixture, for third parties; 

any natural or legal person established within the 
Community, other than the manufacturer or the 
importer, who uses a substance, either on its 
own or in a mixture, in the course of his 
industrial or professional activities. A distributor 
or a consumer is not a downstream user.  A re-
importer, exempted pursuant to Article 2(7)(c) 
REACH Regulation, shall be regarded as a 
downstream user;  

Dangerous Preparations Directive (1999/45/EC); 

Dangerous Substances Directive (67/548/EEC); 

European  Chemicals  Agency  or  “the  Agency,” 
established under the REACH Regulation; 

European Union; 

an article containing one or more explosive 
substances or mixtures;  

a solid or liquid substance or mixture of 
substances which is in itself capable by chemical 
reaction of producing gas at such a temperature 
and pressure and at such a speed as to cause 
damage to the surroundings. Pyrotechnic 
substances are included even when they do not 
evolve gases; 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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Eye irritation  

Flammable gas  

Flammable liquid  

Flash point  

Flammable solid  

GHS  

Hazard category  

Hazard class  

Hazard pictogram  

Hazard statement  

Hazardous  

IMDG Code  

Import  

Guidance on Labelling and Packaging 

Version 2.0 – September 2016 

the production of changes in the eye following 
the application of test substance to the anterior 
surface of the eye, which are fully reversible 
within 21 days of application; 

a gas or gas mixture having a flammable range 
with air at 20 °C and a standard pressure of 
101.3 kPa; 

a liquid having a flash point of not more than 
60°C;  

the lowest temperature (corrected to a standard 
pressure of 101.3 kPa) at which the application of 
an ignition source causes the vapours of a liquid 
to ignite under specified test conditions; 

a solid which is readily combustible, or may 
cause or contribute to fire through friction.  

Readily combustible solids are powdered, 
granular, or pasty substances or mixtures which 
are dangerous if they can be easily ignited by 
brief contact with an ignition source, such as a 
burning match, and if the flame spreads rapidly; 

Globally Harmonised System of Classification and 
Labelling of Chemicals developed within the 
United Nations (UN) structure; 

the division of criteria within each hazard class, 
specifying hazard severity; 

the nature of the physical, health or 
environmental hazard; 

graphical composition that includes a symbol plus 
other graphic elements, such as a border, 
background pattern or colour that is intended to 
convey specific information about the hazard 
concerned; 

a phrase assigned to a hazard class and category 
that describes the nature of the hazards of a 
hazardous substance or mixture, including, where 
appropriate, the degree of hazard; 

means fulfilling the criteria relating to physical 
hazards, health hazards or environmental 
hazards, laid down in parts 2 to 5 of Annex I of 
CLP; 

International Maritime Dangerous Goods Code for 
the transport of dangerous goods by sea; 

the physical introduction into the customs 
territory of the Community; 

 
 
 
 
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Importer  

INCI  

Intermediate packaging  

IUCLID  

IUPAC  

Label  

Label element  

M-factor  

Manufacturer  

Manufacturing  

Mixture  

Mutagen  

Guidance on Labelling and Packaging 

Version 2.0 – September 2016 

any natural or legal person established within the 
Community who is responsible for import; 

International Nomenclature of Cosmetic 
Ingredients; 

packaging placed between inner packaging, or 
articles, and outer packaging; 

International Uniform Chemical Information 
Database; 

International  Union  of  Pure  and  Applied 
Chemistry; 

an appropriate group of written, printed or 
graphic information elements concerning a 
hazardous substances or mixture, selected as 
relevant to the target sector (s), that is affixed 
to, printed on, or attached to the immediate 
container of a hazardous substance or mixture, 
or to the outside packaging of a hazardous 
substances or mixture (definition follows Chapter 
1.2 of the UN GHS); 

one type of information that has been 
harmonised for use in a label, e.g. hazard 
pictogram, signal word; 

a multiplying factor applied to the concentration 
of a substance classified as hazardous to the 
aquatic environment acute category 1 or chronic 
category 1, and is used to derive by the 
summation method the classification of a 
mixture in which the substance is present; 

any natural or legal person established within 
the Community who manufactures a substance 
within the Community; 

production or extraction of substances in the 
natural state; 

means a mixture or solution composed of two or 
more substances. The UN GHS Chapter 1.2 
includes the phrase, “in which they do not react” 
at the end of an otherwise identical definition; 

an agent giving rise to an increased occurrence 
of mutations in populations of cells and /or 
organisms; 

 
 
 
 
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Organic peroxides  

Oxidising gas  

Oxidising liquid  

Oxidising solid  

Package  

Packaging  

Placing on the market  

PPPR 

Guidance on Labelling and Packaging 

Version 2.0 – September 2016 

liquid or solid organic substances which contain 
the bivalent -O-O- structure and may be 
considered derivatives of hydrogen peroxide, 
where one or both of the hydrogen atoms have 
been replaced by organic radicals. The term 
organic peroxides includes organic peroxide 
mixtures (formulations) containing at least one 
organic peroxide. Organic peroxides are 
thermally unstable substances or mixtures, which 
can undergo exothermic self-accelerating 
decomposition. In addition, they can have one or 
more of the following properties:  

(i) be liable to explosive decomposition;  

(ii) burn rapidly;  

(iii) be sensitive to impact or friction;  

(iv) react dangerously with other substances; 

any gas or gas mixture which may, generally by 
providing oxygen, cause or contribute to the 
combustion of other material more than air 
does;  

a liquid substance or mixture which, while in 
itself not necessarily combustible, may, 
generally by yielding oxygen, cause, or 
contribute to, the combustion of other material; 

a solid substance or mixture which, while in 
itself not necessarily combustible, may, 
generally by yielding oxygen, cause, or 
contribute to, the combustion of other material; 

the complete product of the packing operation, 
consisting of the packaging and its contents; 

one or more receptacles and any other 
components or materials necessary for the 
receptacles to perform their containment and 
other safety functions; 

supplying or making available, whether in return 
for payment or free of charge, to a third party.  
Import shall be deemed to be placing on the 
market; 

Regulation (EC) No 1107/2009 of the European 
Parliament and of the Council of 21 October 
2009 concerning the placing of plant protection 
products on the market and repealing Council 
Directives 79/117/EEC and 91/414/EEC; 

 
 
 
 
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Precautionary statement  

Product identifier  

Pyrophoric liquid  

Pyrophoric solid  

Pyrotechnic article  

Pyrotechnic substance or mixture  

REACH or REACH Regulation  

Registrant  

Reproductive toxicity 

Respiratory sensitiser  

SADT   

SDS    

Self-heating substance or mixture  

Guidance on Labelling and Packaging 

Version 2.0 – September 2016 

a phrase that describes recommended 
measure(s) to minimise or prevent adverse 
effects resulting from exposure to a hazardous 
substance or mixture due to its use or disposal; 

details permitting the identification of the 
substance or mixture; 

a liquid substance or mixture which, even in 
small quantities, is liable to ignite within five 
minutes after coming into contact with air; 

a solid substance or mixture which, even in 
small quantities, is liable to ignite within five 
minutes after coming into contact with air; 

an article containing one or more pyrotechnic 
substances or mixtures; 

a substance or mixture of substances designed 
to produce an effect by heat, light, sound, gas or 
smoke or a combination of these as the result of 
non-detonative self-sustaining exothermic 
chemical reactions; 

Regulation (EC) No 1907/2006 concerning the 
Registration, Evaluation, Authorisation and 
Restriction of Chemicals; 

the manufacturer or the importer of a substance 
or the producer or importer of an article 
submitting a registration for a substance under 
the REACH Regulation; 

includes adverse effects on sexual function and 
fertility in adult males and females, as well as 
developmental toxicity in the offspring; 

a substance that will lead to hypersensitivity of 
the airways following inhalation of the 
substance; 

 Self-Accelerating Decomposition Temperature; 

 safety data sheet; 

a liquid or solid substance or mixture, other than 
a pyrophoric liquid or solid, which, by reaction 
with air and without energy supply, is liable to 
self-heat; this substance or mixture differs from 
a pyrophoric liquid or solid in that it will ignite 
only when in large amounts (kilograms) and 
after long periods of time (hours or days); 

 
 
 
 
 
 
 
 
 
 
 
 
 
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Self-reactive substances or mixtures   thermally unstable liquid or solid substances or 

Serious eye damage  

Signal word   

Skin corrosion  

Skin irritation  

Skin sensitiser  

Specific target organ toxicity  

STOT-RE  

STOT-SE  

Substance  

Trade name  

mixtures liable to undergo a strongly exothermic 
decomposition even without participation of 
oxygen (air). This definition excludes substances 
and mixtures classified according to CLP as 
explosives, organic peroxides or as oxidising; 

the production of tissue damage in the eye, or 
serious physical decay of vision, following 
application of a test substance to the anterior 
surface of the eye, which is not fully reversible 
within 21 days of application; 

a word that indicates the relative level of 
severity of hazards to alert the potential reader 
of the hazard; the following two levels are 
distinguished: 

a) Danger means a signal word indicating the 

more severe hazard categories; and 

b) Warning means a signal word indicating 

the less severe hazard categories; 

the production of irreversible damage to the 
skin, namely visible necrosis through the 
epidermis and into the dermis, following the 
application of a test substance up to 4 hours; 

the production of reversible damage to the skin 
following the application of a test substance for 
up to 4 hours; 

a substance that will lead to an allergic response 
following skin contact;  

specific target organ toxicity, cf. STOT, STOT-SE 
and STOT-RE; 

specific target organ toxicity arising from a 
repeated exposure to a substance or mixture; 

specific target organ toxicity arising from a single 
exposure to a substance or mixture; 

a chemical element and its compounds in the 
natural state or obtained by any manufacturing 
process, including any additive necessary to 
preserve its stability and any identified impurity 
deriving from the process used, but excluding 
any solvent which may be separated without 
affecting the stability of the substance or 
changing its composition; 

a designation under which a substance or mixture 
is placed on the market; 

 
 
 
 
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TWD    

UN  

UN GHS  

UN RTDG  

Unstable explosive  

Use  

Guidance on Labelling and Packaging 

Version 2.0 – September 2016 

tactile warnings of danger; 

United Nations; 

Globally Harmonised System of Classification and 
Labelling of Chemicals - the international criteria 
agreed by the United Nation Economic and Social 
Council (UN ECOSOC) for the classification and 
labelling of hazardous substances and mixtures; 

the United Nations Recommendations on the 
Transport of Dangerous Goods; 

an explosive substance or mixture which is 
thermally unstable and/or too sensitive for 
normal handling, transport and use; 

any processing, formulation, consumption, 
storage, keeping, treatment, filling into 
containers, transfer from one container to 
another, mixing, production of an article or any 
other utilisation. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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190 

EUROPEAN CHEMICALS AGENCY 
ANNANKATU 18, P.O. BOX 400, 
FI-00121 HELSINKI, FINLAND 
ECHA.EUROPA.EU