Communication from the Commission to the Council and the European Parliament on the implementation of the Community Strategy for Endocrine Disrupters - a range of substances suspected of interfering with the hormone systems of humans and wildlife (COM (1999) 706)
Date: 2001-06-14
Institutions: European Commission
Subjects: animal health, hormone, illness, public health

COMMISSION OF THE EUROPEAN COMMUNITIES

Brussels, 14.06.2001
COM(2001) 262 final

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Following  the  adoption  by  the  Commission  of  a  Communication  to  Council  and
European  Parliament  on  a  Community  Strategy  for  Endocrine  Disrupters  in  December
1999  (COM(1999)706),  the  Council  invited  the  Commission  to  report  regularly  on  the
progress of work, and for the first time in early 2001.

A key short-term action of the Community Strategy is the establishment of a priority list
of substances for further evaluation of their role in endocrine disruption. During 2000, a
FDQGLGDWH(cid:3)OLVW(cid:3)RI(cid:3)(cid:24)(cid:24)(cid:22)(cid:3)PDQ(cid:16)PDGH(cid:3)VXEVWDQFHV DQG(cid:3)(cid:28)(cid:3)V\QWKHWLF(cid:18)QDWXUDO(cid:3)KRUPRQHV has been
identified. The candidate list has been divided into three separate groupings of substances
depending  on  the  level  of  information  available,  and  a  priority  list  of  actions  has  been
developed  in  order  to  further  evaluate  the  role  of  these  substances  in  endocrine
disruption. Actions, timeframes and groupings of substances are presented in Annex 1 of
this Communication.

Regarding other short-term actions, the Commission is planning D(cid:3)(XURSHDQ(cid:3)ZRUNVKRS
RQ(cid:3)HQGRFULQH(cid:3)GLVUXSWHUV, with the sponsorship of the Swedish Ministry for Environment,
Swedish  National  Chemicals  Inspectorate  (KEMI),  OECD,  WHO  and  the  European
Environment Agency. The workshop will take place on 18-20 June 2001 in Sweden and
will  focus  on  monitoring,  research  and  development,  test  methods/testing  strategy  and
international  cooperation.  The  Commission  has  also  held  meetings  with  WHO  and  the
US EPA during 2000 with a view to enhancing international cooperation.

The  Commission  and  Member  States  continue  to  participate  in  the  OECD  Endocrine
Disrupter Testing and Assessment Task Force, which was set up in 1998 with the goal of
GHYHORSLQJ(cid:3) DJUHHG(cid:3) WHVW(cid:3) PHWKRGV  for  endocrine  disrupters.  The  latest  estimates  are  that
agreed  test  methods  for  human  health  would  be  available  in  2002  while  tests  for
environmental effects are expected in the timeframe of 2003 to 2005.

Under  the  5th  Community  Framework  Programme  for  R&D  (1999-2002),  research  into
endocrine  disruption  has  been  prioritised  in  the  latest  revisions  of  the  relevant
workprogrammes. In addition, a GHGLFDWHG(cid:3)FDOO(cid:3)IRU(cid:3)UHVHDUFK(cid:3)SURSRVDOV on the health and
environmental  implications  of  endocrine  disrupters  was  published  in  May  2001  with  a
budgetary envelope of 20 MEURO.

Finally, regarding OHJLVODWLYH(cid:3)DFWLRQ, the proposed revision of the General Product Safety
Directive  proposes,  inter-alia,  a  simplification  of  conditions  and  procedures  for  urgent
measures at Community level. In addition, the issue of endocrine disrupters is addressed
specifically in the context of new and existing legislation in the field of water policy and
in the recent White Paper on a strategy for a future chemicals policy.

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A  range  of  chemical  substances,  designed  for  use  in  industry,  agriculture  and
consumer  products,  are  suspected  of  interfering  with  the  endocrine  systems  of
humans  and  wildlife  and  of  causing  adverse  health  effects  such  as  cancer,
behavioural  changes  and  reproductive  abnormalities.  These  substances  are
known as “endocrine disrupters”.

In  December  1999,  the  Commission  adopted  a  Communication  to  the  Council
and  European  Parliament  on  a  Community  Strategy  for  Endocrine  Disrupters.
The strategy addresses the key requirements of further  UHVHDUFK(cid:30)(cid:3)LQWHUQDWLRQDO
FR(cid:16)RSHUDWLRQ(cid:30)(cid:3) FRPPXQLFDWLRQ(cid:3) WR(cid:3) WKH(cid:3) SXEOLF(cid:30)(cid:3) DQG(cid:3) DSSURSULDWH(cid:3) SROLF\(cid:3) DFWLRQ(cid:17)
Recommendations are made for short-, medium- and long-term actions.

On  30  March  2000  the  Environment  Council  adopted  Conclusions  on  the
Commission Communication in which it stressed the SUHFDXWLRQDU\(cid:3)SULQFLSOH(cid:15)
the need to develop quick and effective risk management strategies and the need
for  consistency  with  the  overall  chemicals  policy.  The  Council  invited  the
Commission to report back on the progress of the work at regular intervals, and
for the first time in early 2001

On  26  October  2000,  the  European  Parliament  adopted  a  Resolution  on
endocrine disrupters, emphasising the application of the precautionary principle
and calling on the Commission to identify substances for immediate action.

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One  of  the  first  key  short-term  actions  identified  in  the  Communication  is  the
establishment of a priority list of substances for further evaluation of their role
in endocrine disruption. The priority list was to be established in two steps, first
an  independent  review(cid:3) of  evidence  of  endocrine  disrupting  effects  and
human/wildlife  exposure  and  second  a  priority-setting  exercise  in  consultation
with  stakeholders  and  the  Commission  Scientific  Committees.  The  two-step
process is illustrated in Figure 1 attached.

The ILUVW(cid:3)VWHS resulted in a study report entitled “Towards the establishment of a
priority  list  of  substances  for  further  evaluation  of  their  role  in  endocrine
disruption – preparation of a candidate list of substances as a basis for priority-
setting”.  The  study  was  carried  out  by  BKH  Consulting  Engineers,  NL,  under
contract to the European Commission, DG Environment. The report focused on
man-made  chemicals  used  primarily  in  industry,  agriculture  and  consumer
goods and was completed in June 2000.

The  study  report  identified  a  FDQGLGDWH(cid:3) OLVW(cid:3) RI(cid:3) (cid:24)(cid:24)(cid:22)(cid:3) VXEVWDQFHV  which  were
grouped into three groups according to different levels of available information
for  four  selection  criteria.  The  selection  criteria,  chosen  in  consultation  with
stakeholders, were as follows:

3

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9. 

10. 

11. 

•  Production volume

•  Persistence in the environment

•  Evidence of endocrine disruption from scientific literature, and

•  Exposure considerations

For the VHFRQG(cid:3)VWHS, priority-setting,  the Commission  Scientific Committee  for
Toxicity,  Ecotoxicty  and  the  Environment,  in  association  with  the  Scientific
Committee  for  Plants,  was  consulted  on  the  scientific  relevance  of  the  BKH
Report.  The  2SLQLRQ(cid:3) DGRSWHG(cid:3) RQ(cid:3) (cid:24)(cid:3) 6HSWHPEHU(cid:3) (cid:21)(cid:19)(cid:19)(cid:19)  supported  the  stepwise
approach for the selection of substances for prioritisation and further evaluation.
It  concluded  however  that  there  were  important  scientific  shortcomings  in  the
BKH  report,  and  identified  namely  the  need  to  address  dose-response/potency
considerations, synthetic hormones, quantification of exposure as well as cut-off
points for production volume and persistence criteria.

In parallel, stakeholders, including EU Member and Associated States, industry
associations  and non-governmental organisations were  consulted. The  majority
view of 0HPEHU(cid:3)6WDWHV(cid:3)DQG(cid:3)1*2V was that the BKH approach was a pragmatic
one which was reasonable for a first cut of the data and that it could be used as a
first step in developing the priority list. At the same time, the need for additional
work to improve and develop the list was emphasised.

The  FKHPLFDO(cid:3) LQGXVWU\  expressed  its  concern  that  the  BKH  process  might  be
perceived as a valid risk assessment because it appeared to combine hazard and
exposure  in  a  single  assessment  in  a  simplistic  way.  In  addition,  the  chemical
industry submitted a document described as “an alternative to the approach used
by BKH”.

On  8-9  November  2000,  a  stakeholder  meeting  was  held  in  Brussels.  Priority-
setting  was  discussed  in  the  light  of  the  Opinion  of  the  Scientific  Committee,
comments  from  stakeholders  and  an  analysis  of  the  legal  status  of  substances
under  existing  Community  legislation.  Several  points  relating  to  the  BKH
Report and to the list to be established were noted:

•  The study carried out by BKH was designed as a VWDUWLQJ(cid:3)SRLQW in a priority-

setting exercise.

•  All 553 candidate substances would be retained for further evaluation.

•  A more in-depth study of specific candidate substances than that contained in
the  BKH  Report  would  be  necessary  before  any  proposals  for  restrictions
could be envisaged.

•  Of  118  candidate  substances  deemed  to  have  evidence  of  endocrine
disruption or potential endocrine disruption, 109 were already subject to bans
or restrictions or were being addressed under existing Community legislation,
although for reasons not necessarily related to endocrine disruption.

4

•  In  addition  to  the  man-made  substances  identified  in  the  BKH  Report,
natural, identical to natural and synthetic hormones would also be considered
as  candidate  substances.  These  substances  are  already  subject  to  a  ban  for
growth promotion in stock-farming in the European Union.

•  In  the  context  of  the  Community  Strategy  for  Endocrine  Disrupters,  the
Commission  does  not  intend  to  duplicate  work  on  candidate  substances  for
which  risk  assessments  are  underway  or  due  under  existing  Community
legislation.

•  The  process  of  identifying  candidate  substances  is  iteractive  and  allows  for

inclusion and exclusion of substances as new evidence comes to light.

12. 

As a result of the two-step process described above, the Commission intends to
implement  a  priority  list  of  actions  relating  to  specific  groupings  of  candidate
substances.  These  actions  are  listed  in  Annex  1,  Table  1.  Of  particular
importance are the following actions:

•  Priority in the short-term (within 12-18 months) will be given to conducting
an  in-depth  evaluation  of  12  candidate  substances.  Nine  (9)  of  these  are
industrial  or  other  substances  for  which  there  is  scientific  HYLGHQFH(cid:3) RI
HQGRFULQH(cid:3) GLVUXSWLRQ  or  SRWHQWLDO  endocrine  disruption  and  which  are
QHLWKHU(cid:3) UHVWULFWHG  QRU(cid:3) FXUUHQWO\(cid:3) EHLQJ(cid:3) DGGUHVVHG(cid:3) XQGHU(cid:3) H[LVWLQJ
&RPPXQLW\(cid:3) OHJLVODWLRQ(cid:3) (see  Annex  1,  Table  2).  In  order  to  address  the
scientific shortcomings of the BKH Report, the evaluation will consider up-
to-date  ED  evidence, 
including  dose/response/potency/timing/synergy
considerations,  comparison  with  normal  toxicity  data,  and  quantitative
exposure  assessment  where  appropriate.  Exposure  assessment  will  include
the identification of specific cases of consumer or ecosystem exposure which
might  warrant  special  consideration  in  the  short-term.  In  addition,  three  (3)
synthetic/natural  hormones,  oestrone,  ethinyl  oestradiol  and  oestradiol,  will
be  evaluated  in  order  to  gather  up-to-date  evidence  of  environmental
exposure and effects related to these substances. The Commission intends to
launch a study in order to undertake this work.

•  Priority  will  also  be  given  in  the  next  12-18  months  to  gathering
data/information on persistence, production volumes  and  legal  status  of  435
candidate substances (see Annex 1, Table 4) for which there was LQVXIILFLHQW
GDWD  in  the  BKH  Report  to  decide  on  ED  or  potential  for  ED.  The
Commission intends to launch a second study in order to undertake this work.

•  For 46 candidate substances for which there is deemed to be HYLGHQFH(cid:3)RI(cid:3)(’
RU(cid:3) SRWHQWLDO(cid:3) (’  and  which  are  VXEMHFW(cid:3) WR(cid:3) ULVN(cid:3) DVVHVVPHQW(cid:3) under  existing
Community  legislation  (see  Annex  1,  Table  3,  shaded  substances)  the
Commission  will  invite  Member  State  Competent  Authorities  to  take
available  evidence  of  endocrine  disruption  into  account  during  the  risk
assessment  process.  The  Commission  will  invite  Member  States  Competent
Authorities to speed up the risk assessments and risk reduction strategies for
15 candidate ED substances  which  are priority substances under Regulation
793/93 and to speed up the risk assessment and authorisation process for 31

5

candidate ED substances which are under review under Directive 91/414 for
plant  protection  products.  This  work  is  estimated  to  require  a  timeframe  of
between 1-4 years.

•  For  2  candidate  substances  for  which  there  is  scientific  evidence  of  ED  or
potential  ED  and  which  are  QHLWKHU  UHVWULFWHG(cid:15)(cid:3) FODVVLILHG  QRU  EHLQJ
DGGUHVVHG(cid:3) XQGHU(cid:3) H[LVWLQJ(cid:3) &RPPXQLW\(cid:3) OHJLVODWLRQ(cid:15)  (see  Annex  1,  Table  2,
shaded substances), the Commission will invite the Member State Competent
Authorities  to  carry  out  classification  under  Dir  67/548  using  existing  test
results  for  carcinogenicity,  reproductive 
the
environment. This is estimated to require a 1-2 year timeframe.

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13. 

The  Commission  has  recently  launched  a  study  concerning  the  exposure  of
human  beings  to  endocrine  disrupters  through  drinking  water.  This  study  has
been launched at the request of the Council in the context of Directive 98/83/EC
on  the  quality  of  water  intended  for  human  consumption  (Drinking  Water
Directive).  The  goal  of  the  study  is  to  gather  evidence  on  which  to  base
parametric values for endocrine-disrupting chemicals which might be used in a
future revision of the Directive.

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The Commission and WHO held a joint seminar on 19-20 September 2000 with
a  view  to  enhancing  cooperation  between  the  two  organisations.  Regarding
endocrine  disrupters,  the  Commission  and  WHO,  through  the  International
Programme for Chemical Safety, are already cooperating on the maintenance of
a global research inventory which is housed at the Commission Joint Research
Centre  in  Ispra  and  on  the  compilation  of  a  global  state-of-the-science
assessment report.

The  development  of  agreed  test  methods  is  addressed  within  the  forum  of  the
OECD.  Both  the  Commission  and  WHO  are  committed  to  supporting  this
process,  WHO  in  the  framework  of  the  Inter-Organisation  Programme  for  the
Sound  Management  of  Chemicals  (IOMC)  and  the  Commission  by  working
closely with EU Member States to coordinate EU input at OECD. In the longer-
term, it is expected that both organisations could work jointly on evaluating the
impact of test methods on current risk assessment approaches.

Endocrine disruption was also addressed at the EU-US High Level Consultation
on the Environment on 10-11 May 2000. The Commission and US EPA agreed
to share information on a regular basis on priority-setting, screening and testing
as well as on research activities.

Endocrine  disruption  is  one  of  the  chapters  within  the  frame  of  the  EU-US
agreement  on  cooperation  in  science  and  technology.  In  this  context,  a  joint
workshop  was  organized  in  Ispra  by  the  Commission  JRC  in  April  1999  at
which  common  research  priorities  were  identified.  Recently,  the  US  EPA
published  two  calls  for  research  proposals  focused  on  ecological  and  human
health  effects  of  EDs  and  is  due  to  publish  another  in  2001.  In  addition,  the
launched  a  dedicated  call  for  proposals  on  health  and
Commission 
environmental implications of EDs on 31 May 2001.

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The use of substances having an oestrogenic, gestagenic or androgenic effect is
restricted  under  Directive  96/22/EC  concerning  the  prohibition  on  the  use  in
stock-farming of certain substances having a hormonal or thyrostatic action and
beta-agonists.  In  April  1999,  the  Scientific  Committee  on  Veterinary  matters
relating  to  Public  Health  concluded  that  for  all  six  hormones  endocrine,
developmental,  immunological,  neurobiological,  immunotoxic,  genotoxic  and
carcinogenic effects could be envisaged and that of the various susceptible risk
groups,  prepubertal  children  is  the  group  of  greatest  concern.  Moreover,  the
Scientific  Committee  concluded  that  oestradiol  17  beta  is  a  complete
carcinogen.  In  the  light  of  these  conclusions,  confirmed  in  May  2000,  the
Commission has proposed to definitively ban the use of oestradiol 17 beta and
its  ester-like  derivatives  in  farm  animals  and  to  maintain  provisionally  the
prohibition for growth promotion of all other substances having an oestrogenic,
gestagenic  or  androgenic  effect  until  more  complete  scientific  information
becomes available (COM (2000) 320 and COM (2001) 131).

The  Commission  is  planning  to  hold  a  European  workshop  on  endocrine
disrupters on 18-20 June 2001 in Aronsborg (Bålsta), Sweden, with sponsorship
from  Swedish  Ministry  from  Environment,  Swedish  National  Chemicals
Inspectorate  (KEMI),  OECD,  WHO  and  the  European  Environment  Agency.
The  workshop  is  intended  as  a  means  to  follow  up  on  several  elements  of  the
Community  strategy  on  endocrine  disrupters  (COM(1999)706),  including  the
establishment  of  monitoring  programmes, 
information  exchange  and
international  coordination,  development  of  test  methods/testing  strategy,  and
research and development. Further information on the detailed objectives of the
workshop are provided in Annex 2.

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21. 

As indicated in the Commission Communication, the availability of agreed test
strategies/methods  to  identify  and  assess  endocrine  disrupting  chemicals  is  a
basic  requirement  for  comprehensive  legislative  action  aimed  at  protecting
people  and  the  environment  from  the  potential  dangers  posed  by  these
chemicals.

The  Commission  participates  in  the  OECD  Endocrine  Disrupters  Testing  and
Assessment Task Force (EDTA) which was set up in 1998 under the authority of
the National Co-ordinators for the Test Guidelines Programme. The main duties
of the Task Force are to develop an internationally harmonised testing strategy
and  to  co-ordinate  and  oversee  the  work  of  different  sub-groups  charged  to
develop  new  test  guidelines  or  revise  existing  ones  to  assess  the  potential
endocrine disrupting properties of chemicals. The Task force has met four times
and has outlined a first conceptual framework for a possible testing strategy and
defined a set of test methods to be developed/validated.

22. 

For  the  development/validation  of  test  methods  for  human  health  effects,  the
Task  Force  set  up  a  working  group  in  1998.  This  group,  which  includes

7

23. 

Commission and Member State experts, has been focusing on the development
of two new tests and the enhancement of an existing guideline and it is expected
that  agreed  tests  for  human  health  could  be  available  in  2002.  In  parallel  the
revision  of  Test  Guideline  416  (Two  Generation  Reproductive  Toxicity)  and
OECD TG 414 (Teratogenicity) are  currently in the  final phase of adoption by
the  Member  countries.  These  revisions  include  many  additions  relevant  to  the
detection of sex hormone disruption, although there is still a need in the future to
consider additional endpoints, particularly  those relating to  the  central  nervous
system and thyroid hormone system.

For  the  development/validation  of  test  methods  for  environmental  effects,  a
second working group was established in late 2000, in which Commission and
Member State experts participate. Suitable tests regarding environmental effects
are not well-developed. Tests are required which assess the effects of chemicals
on  a  variety  of  key  taxonomic  groups  from  all  the  relevant  environmental
compartments (fish, avians, invertebrates, amphibians). In view of the different
degrees  of  knowledge  on  each  compartment  and  test  development,  it  is
necessary  to  identify  relevant  toxicity  endpoints  in  order  to  obtain  a
representative  picture  of  the  effects  on  the  environment.  Due  to  the  lack  of
development  of  these  tests,  it  is  unlikely  that  the  first  agreed  methods  will  be
available before 2003 and some of them not before 2005.

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the  Fourth  Community  Framework  Programme 

In 
for  Research  and
Technological Development (1994-1998), successful projects were funded in the
areas of identification and detection of endocrine disrupting substances in waste
water treatment, biosensor development, the impacts of endocrine disrupters on
human  and  ecosystems  health  and  development  of  test  methods.  The
Community funding for these projects was circa 8 million Euros. In addition the
Commission (Joint Research Centre/DG Research) is funding a scientific project
which  aims  to  screen  the  EU  high  production  volume  existing  chemicals  for
potential endocrine modulating chemicals.

In the Fifth Community Framework Programme for Research and Technological
Development (FP5) (1999-2002), ED is addressed under several key actions of
the  “Quality  of  Life  and  Management  of  Living  Resources”  and  the  “Energy,
Environment  and  Sustainable  Development”  programmes.  However,  the  calls
for  proposals  in  1999  yielded  only  one  project  clearly  dedicated  to  ED  in  the
Quality  of  Life  programme  (Key  Action:  Environment  and  Health),  with  a
European  contribution  of  2.45  M…(cid:17)(cid:3) 7KLV(cid:3) SURMHFW(cid:3) DGGUHVVHV(cid:3) PDOH(cid:3) UHSURGXFWLYH
health.

For  the  year  2000,  4  proposals  specifically  dedicated  to  endocrine  disruption
have reached the funding stage in the Quality of Life Programme (Key Action:
Environment and Health). These proposals address essentially male reproductive
health and the effects of phytoestrogens in the human diet. The total Community
contribution to these projects is around 8 M…(cid:17)(cid:3)6HYHUDO(cid:3)RWKHU(cid:3)SURMHFWV(cid:3)LQ(cid:3)WKH(cid:3)VDPH
programme  investigate  human  health  effects  of  substances  suspected  of  being
endocrine  disrupters  (e.g.  dioxins,  PCB,  PAH,  flame  retardants)  without

8

27. 

28. 

focussing  specifically  on  this  single  issue.  These  projects  receive  a  total
European contribution in excess of 10 M…(cid:17)

In the Energy, Environment and Sustainable Development Programme, several
projects, focusing not only on endocrine disruption but also on ecotoxicological
research of possible endocrine substances in freshwater and marine ecosystems,
have been selected for funding under the key actions "Sustainable management
and quality of water" and " Marine ecosystems”.

In  order  to  better  cater  for  the  research  needs  related  to  ED,  the  profile  of  the
issue has been raised throughout the relevant programmes of FP5 for years 2001
and 2002. Specific research priorities focused on endocrine disrupters have been
included  in  the  revised  workprogramme  of  the  Environment  and  Sustainable
Development Programme to cover the last two calls for proposals in FP5. Under
the  key  action  "Sustainable  management  and  quality  of  water"  these  priorities
include  research  on  endocrine  disrupters  in  the  following  fields:  ecosystem
functioning,  quality  of  drinking  water,  combating  diffuse  pollution,  pre-
normative  and  co-normative  research  including  standardization.  Under  the  key
action  "Marine  ecosystems"  special  priority  for  endocrine  disrupters  has  been
emphasized  in  the  sub-area  related  to  the  assessment  of  nutrient  and  pollutant
impacts on the marine environment.

29. 

Additionally, to further improve the policy support and in order to create a pool
of  research  to  help  resolve  the  large  remaining  uncertainties,  the  Commission
(DG Research) has published a GHGLFDWHG(cid:3)FDOO(cid:3)IRU(cid:3)SURSRVDOV(cid:3)RQ(cid:3)WKH(cid:3)KHDOWK(cid:3)DQG
HQYLURQPHQWDO(cid:3)LPSOLFDWLRQV(cid:3)RI(cid:3)HQGRFULQH(cid:3)GLVUXSWHUV(cid:3)on 31 May 2001  with a
deadline of 14 September 2001. The allocated budget is 20 M euros.

3URJUHVV(cid:3)RQ(cid:3)ORQJ(cid:16)WHUP(cid:3)DFWLRQ

/HJLVODWLYH(cid:3)DFWLRQ

30. 

As outlined in Point 12 of this Communication, a key priority action in 2001 is
the  in-depth  evaluation  of  12  candidate  ED  substances,  which  will  include  the
identification of specific cases of consumer or ecosystem exposure which might
warrant  special  consideration  in  the  short-term.  In  the  context  of  consumer
exposure, Directive 92/59/EC on JHQHUDO(cid:3)SURGXFW(cid:3)VDIHW\ has been identified in
the  Commission  Communication  (COM(1999)706)  as  a  key  risk  management
instrument  for  short-term  emergency  action.  It  should  be  noted  that  this
Directive is under revision, with proposed amendments covering a clarification
and  enlargement  of  the  scope  of  the  Directive,  a  stronger  role  for  European
standards, additional obligations for producers and distributors, a ban on export
of  prohibited  products,  reinforcement  of  the  obligations  and  powers  of  the
Member  States  for  market  surveillance,  collaboration  between  Member  States
and  the  Commission,  improvement  of  the  RAPEX  system,  a  simplification  of
conditions and procedures for urgent measures at Community level and last but
not least an improvement in transparency to the general public.

31. 

Directive  2000/60/EC,  the  Water  Framework  Directive,  was  adopted  in
September 2000. Following this, on 16 January 2001, the Commission adopted
an amended Proposal for a Council/European  Parliament  Decision  establishing

9

32. 

the  list  of  priority  substances  in  the  field  of  ZDWHU(cid:3) SROLF\  (COM(2001)17).
Directive  2000/60/EC  stipulates  that,  following  adoption  of  this  Decision,  the
Commission shall produce proposals for emission controls and quality standards
within  two  years.  For  so-called  “priority  hazardous  substances”,  the  proposals
for  emission  controls  shall  aim  to  end  or  phase  out  emissions,  discharges  and
losses  within  20  years.  It  should  be  noted  that,  of  the  32  priority  substances
proposed in the field of water policy, 11 are candidate ED substances for which
evidence of ED or potential ED was found in the BKH Report.

On 13 February 2001, the Commission adopted a :KLWH(cid:3)3DSHU(cid:3)RQ(cid:3)D(cid:3)6WUDWHJ\
IRU  D(cid:3) )XWXUH(cid:3) &KHPLFDOV(cid:3) 3ROLF\.  One  of  the  key  elements  of  the  proposed
strategy  is  an  authorisation  procedure  for  substances  of  very  high  concern,
namely,  substances  that  are  carcinogenic,  mutagenic  or  toxic  to  reproduction
and  substances  with  POPs  characteristics.  The  procedure  would  require
authorities to give specific permission before such a substance could be used for
a  particular  purpose,  marketed  as  such  or  as  a  component  of  a  product.  Given
that many of the serious human health effects which have so far been associated
with endocrine disrupting chemicals are testicular cancer, breast cancer, prostate
cancer, decrease in sperm concentration and semen volume, cryptorchidism and
hypospadia, it is likely that many ED candidate substances would fall under this
authorisation  procedure.  Furthermore,  adverse  effects  on  the  endocrine  system
of wildlife species have been causally linked to  certain  POPs,  which would  be
subject to authorisation.  In addition, the  need  for  particular  research  efforts  on
endocrine disruption are highlighted in the White Paper. These include research
into the development and validation of in-vivo and in-vitro test methods as well
as modelling (e.g. QSAR) and screening methods, and research into the effect of
low doses, long term exposure and exposure to mixtures of chemicals.

Other issues pertinent to the issue of endocrine disruption, which are addressed
in  the  context  of  the  overall  chemicals  policy,  include  the  rigorous  testing  for
long-term effects of substances exceeding a production volume of 100 t and the
obligation  of  manufacturers/importers  and  downstream  users  to  carry  out
appropriate risk assessments.

&RQFOXVLRQV(cid:3)DQG(cid:3)QH[W(cid:3)VWHSV

33. 

The \HDU(cid:3)(cid:21)(cid:19)(cid:19)(cid:19)(cid:3)has been dedicated to a number of SUHSDUDWRU\(cid:3)DFWLYLWLHV towards
the  implementation  of  the  Community  Strategy  for  Endocrine  Disrupters  as
adopted by the Commission in December 1999 (COM(1999)706). These include
the  identification  and  prioritisation  of  a  candidate  list  of  ED  substances  for
further evaluation, the preparation of research priorities to feed into a dedicated
call  for  research  proposals  on  ED  under  the  5th  Community  Framework
Programme  on  R&D  and  the  planning  of  a  European  workshop  on  endocrine
disrupters.  2QJRLQJ(cid:3) DFWLYLWLHV  during  2000  included  the  development  of  test
methods in the context of the OECD Task Force for the Assessment and Testing
of endocrine disrupters.

34. 

The  \HDU(cid:3) (cid:21)(cid:19)(cid:19)(cid:20)  will  be  dedicated  to  the  IXUWKHU(cid:3) HYDOXDWLRQ(cid:3) RI(cid:3) WKH(cid:3) UROH(cid:3) RI
FDQGLGDWH(cid:3)VXEVWDQFHV(cid:3)LQ(cid:3)HQGRFULQH(cid:3)GLVUXSWLRQ, with first priority given to those
substances with evidence of ED or potential ED which are neither restricted nor
currently being addressed under existing(cid:3)Community legislation. The evaluation

10

35. 

36. 

37. 

will  include  the  identification  of  specific  cases  of  consumer  or  ecosystem
exposure  which  might  warrant  special  consideration  from  a  consumer  and
environmental policy point of view in the short-term.

Equally, priority will be given during (cid:21)(cid:19)(cid:19)(cid:20)(cid:16)(cid:21)(cid:19)(cid:19)(cid:21) to JDWKHULQJ(cid:3)GDWD on a range of
candidate ED substances and to launching a series of UHVHDUFK(cid:3)SURMHFWV aimed at
filling  the  gaps  in  knowledge  and  understanding  of  the  phenomenon  of
endocrine disruption. In addition, the Commission invites the Member States to
VSHHG(cid:3) XS(cid:3) WKH(cid:3) FXUUHQW(cid:3) ULVN(cid:3) DVVHVVPHQW(cid:3) SURFHVVHV  for  existing  substances  and
plant protection products which appear on the ED candidate list and which are
being addressed under existing Community legislation.

A  European  workshop  on  endocrine  disrupters  will  take  place  on  18-20  June
2001  in  Aronsborg  (Bålsta),  Sweden.  The  workshop  will  address 
the
establishment  of  PRQLWRULQJ  programmes,  the  development  of  DJUHHG(cid:3) WHVW
PHWKRGV(cid:18)WHVWLQJ(cid:3) VWUDWHJ\(cid:15)(cid:3)
LQWHUQDWLRQDO(cid:3) FRRSHUDWLRQ  and  UHVHDUFK(cid:3) DQG
GHYHORSPHQW.

In  parallel  with  the  above  specific  activities  in  the  context  of  the  Community
Strategy  for  Endocrine  Disrupters,  the  issue  of  endocrine  disruption  is  also
addressed, either directly or indirectly, in a new legislative proposal in the field
of ZDWHU(cid:3)SROLF\, in the recent White Paper on a strategy for a IXWXUH(cid:3)FKHPLFDOV
SROLF\ and in the proposed revision of the *HQHUDO(cid:3)3URGXFW(cid:3)6DIHW\ Directive.

11

12

$QQH[(cid:3)(cid:20)

6XEVWDQFHV
DUH
ZKLFK(cid:3)
GHHPHG(cid:3) 127(cid:3) WR
EH(cid:3) (’V(cid:15)(cid:3) RQ(cid:3) WKH
EDVLV(cid:3)
RI
DYDLODEOH(cid:3) GDWD(cid:3) –
VHH(cid:3)7DEOH(cid:3)(cid:24)

7DEOH(cid:3)(cid:20):

Priority List of Actions with groupings of substances and estimated timeframes

6XEVWDQFHV(cid:3)
ZLWK
HYLGHQFH(cid:3) RI(cid:3) (’(cid:3) RU
SRWHQWLDO(cid:3) (’(cid:3) ZKLFK
QHLWKHU
DUH(cid:3)
UHVWULFWHG(cid:3)
QRU
EHLQJ
FXUUHQWO\(cid:3)
DGGUHVVHG(cid:3)
XQGHU
H[LVWLQJ(cid:3)&RPPXQLW\
OHJLVODWLRQ(cid:3)
VHH
7DEOH(cid:3)(cid:21)

(cid:16)(cid:3)

Estimated
timeframe

12-18 months

*URXSLQJV(cid:3)RI(cid:3)VXEVWDQFHV

$FWLRQV

&RQGXFW(cid:3) LQ(cid:16)GHSWK(cid:3) VWXGLHV(cid:3) RI(cid:3) LQGLYLGXDO
VXEVWDQFHV(cid:15)(cid:3) IRFXVLQJ(cid:3) RQ(cid:3) XS(cid:16)WR(cid:16)GDWH(cid:3) (’
HYLGHQFH(cid:15)(cid:3)
LQFOXGLQJ
GRVH(cid:18)UHVSRQVH(cid:18)SRWHQF\(cid:18)WLPLQJ(cid:18)V\QHUJ\
FRQVLGHUDWLRQV(cid:15)(cid:3) FRPSDULVRQ(cid:3) ZLWK(cid:3) QRUPDO
WR[LFLW\(cid:3) GDWD(cid:15)(cid:3) DQG(cid:3) TXDQWLWDWLYH(cid:3) H[SRVXUH
DVVHVVPHQW(cid:3)ZKHUH(cid:3)DSSURSULDWH(cid:17)(cid:3)([SRVXUH
DVVHVVPHQW(cid:3)ZLOO(cid:3)LQFOXGH(cid:3)WKH(cid:3)LGHQWLILFDWLRQ
RI(cid:3) VSHFLILF(cid:3) FDVHV(cid:3) RI(cid:3) FRQVXPHU(cid:3) RU
HFRV\VWHP(cid:3)H[SRVXUH(cid:3)ZKLFK(cid:3)PLJKW(cid:3)ZDUUDQW
VSHFLDO(cid:3)FRQVLGHUDWLRQ(cid:3)LQ(cid:3)WKH(cid:3)VKRUW(cid:16)WHUP(cid:17).

*DWKHU(cid:3)EDVLF(cid:3)LQIRUPDWLRQ(cid:3)RQ(cid:3)SHUVLVWHQFH(cid:15)
SURGXFWLRQ(cid:3) YROXPHV(cid:15)(cid:3)
OHJDO(cid:3) VWDWXV(cid:3) RI
VXEVWDQFHV.

6XEVWDQFHV(cid:3) ZLWK(cid:3) HYLGHQFH
RI(cid:3) (’(cid:3) RU(cid:3) HYLGHQFH(cid:3) RI
SRWHQWLDO(cid:3) (’(cid:15)(cid:3) DOUHDG\
UHJXODWHG(cid:3)
EHLQJ
DGGUHVVHG(cid:3) XQGHU(cid:3) H[LVWLQJ
OHJLVODWLRQ(cid:3)–(cid:3)VHH(cid:3)7DEOH(cid:3)(cid:22)

RU(cid:3)

ZLWK
6XEVWDQFHV(cid:3)
LQ
LQVXIILFLHQW(cid:3) GDWD(cid:3)
WR
%.+(cid:3)
GHFLGH(cid:3)
(’
HYLGHQFH(cid:3) –(cid:3) VHH(cid:3) 7DEOH
(cid:23)

5HSRUW(cid:3)
RQ(cid:3)

6XEVWDQFHV(cid:3)
OLWWOH(cid:3) RU(cid:3) QRWKLQJ(cid:3)
NQRZQ

IRU(cid:3) ZKLFK
LV

Estimated timeframe

Estimated timeframe

12-18 months

2+ years

13

,QYLWH(cid:3) 0HPEHU(cid:3)
&RPSHWHQW
$XWKRULWLHV(cid:3) WR(cid:3) VSHHG(cid:3) XS(cid:3) ULVN(cid:3) DVVHVVPHQW
XQGHU(cid:3)5HJ(cid:3)(cid:26)(cid:28)(cid:22)(cid:18)(cid:28)(cid:22)(cid:3)DQG(cid:3)’LU(cid:3)(cid:28)(cid:20)(cid:18)(cid:23)(cid:20)(cid:23).

6WDWH(cid:3)

Estimated timeframe

1-4 years

6WDWH(cid:3)

,QYLWH(cid:3) 0HPEHU(cid:3)
&RPSHWHQW
$XWKRULWLHV(cid:3) WR(cid:3) FDUU\(cid:3) RXW(cid:3) FODVVLILFDWLRQ
XQGHU(cid:3) ’LU(cid:3) (cid:25)(cid:26)(cid:18)(cid:24)(cid:23)(cid:27)(cid:3) XVLQJ(cid:3) H[LVWLQJ(cid:3) WHVW
UHVXOWV(cid:3) IRU(cid:3) FDUFLQRJHQLFLW\(cid:15)(cid:3) UHSURGXFWLYH
WR[LFLW\(cid:3)DQG(cid:3)GDQJHU(cid:3)WR(cid:3)WKH(cid:3)HQYLURQPHQW.

Estimated
timeframe

1-2 years

,GHQWLI\(cid:3)FDQGLGDWHV(cid:3)IRU(cid:3)VFUHHQLQJ(cid:3)WHVWV

,GHQWLI\(cid:3)FDQGLGDWHV(cid:3)IRU(cid:3)GHILQLWLYH(cid:3)WHVWV

Estimated
timeframe

1.5+years

Estimated timeframe

1.5+years

&RQGXFW(cid:3) IXUWKHU(cid:3) UHVHDUFK(cid:3) WR(cid:3) JHQHUDWH(cid:3) QHZ
GDWD(cid:18)LQIRUPDWLRQ

&RQGXFW(cid:3)IXUWKHU(cid:3) UHVHDUFK(cid:18)GHYHORS(cid:3) TXLFN(cid:3) DQG
HIIHFWLYH(cid:3)VFUHHQLQJ(cid:3)WHVWV

14

Estimated timeframe

Estimated timeframe

2+years

2+years

Estimated timeframe

Estimated timeframe

2+years

2+years

Estimated timeframe

2+ years

7DEOH(cid:3)(cid:21)(cid:29)

6XEVWDQFHV(cid:3)ZLWK(cid:3)HYLGHQFH(cid:3)RI(cid:3)(’(cid:3)RU(cid:3)SRWHQWLDO(cid:3)(’(cid:3)ZKLFK(cid:3)DUH(cid:3)QHLWKHU(cid:3)UHVWULFWHG(cid:3)QRU(cid:3)FXUUHQWO\(cid:3)EHLQJ(cid:3)DGGUHVVHG(cid:3)XQGHU(cid:3)H[LVWLQJ

&RPPXQLW\(cid:3)OHJLVODWLRQ(cid:3)(cid:11) (cid:3)(cid:28)(cid:12)

CASNR

Name

Type chem* Status  under
Dir 76/769**

Reg
793/93**
List 1-4

Status  under  Reg
793/93

Dir 
91/414**
Authorised in EU

Status  of  review  under
Dir 91/414

Dir 
Classification

67/548**

140-66-9

4-tert-Octylphenol=1,1,3,3-Tetramethyl-4-
butylphenol

Industrial

99-99-0

4-Nitrotoluene

108-46-3

Resorcinol

120-83-2

2,4 Dichlorophenol

59-50-7

4-chloro-3-methylphenol

1675-54-3

2,2’-bis(4-(2,3-epoxypropoxy)phenyl)
propane  =  2,2’-[(1-methylethylidene)bis(4,1-
phenyleneoxymethylene)]bisoxirane

No CAS 046

2,2’,4,4’-Tetrabrominated 
(2,2’,4,4’-tetraBDE)

diphenyl 

ether

90-43-7

o-phenylphenol

75-15-0

Carbon disulphide

Other
substance

Other
substance

Industrial

Industrial

Industrial

Industrial
by-product

Industrial

Other
substance

* Substances are broadly grouped into industrial chemicals, pesticides, metals, other substances and natural/synthetic hormones.
**
Dir 76/769 = Directive 76/769/EEC relating to restrictions on marketing and use of certain dangerous substances and preparations
Reg 793/93 =Regulation (EEC) No.793/93 for Risk Assessment of Existing Substances
Dir 91/414 = Directive 91/414/EEC concerning the placing on the market of Plant Protection Products
Dir 67/548 = Directive 67/548/EEC on classification, packaging and labelling of dangerous substances

15

T;  R23/24/25;  R33;  N;
R51-53

Xn;  R22;  Xi;  R36/38;
N; R50

Xn;  R21/22;  C;  R34;
N; R51-53

Xn;R21/22;Xi;R41R43

Xi; R36/38; R43;

Xi; R36/37/38; N;R50;

F;  R11;  Repr.  Cat.  3;
R62-63; T; R48/23

7DEOH(cid:3)(cid:22)(cid:29)

6XEVWDQFHV(cid:3)ZLWK(cid:3)HYLGHQFH(cid:3)RI(cid:3)(’(cid:3)RU(cid:3)HYLGHQFH(cid:3)RI(cid:3)SRWHQWLDO(cid:3)(’(cid:15)(cid:3)DOUHDG\(cid:3)UHJXODWHG(cid:3)RU(cid:3)EHLQJ(cid:3)DGGUHVVHG(cid:3)XQGHU(cid:3)H[LVWLQJ

OHJLVODWLRQ(cid:3)(cid:11) (cid:3)(cid:20)(cid:20)(cid:24)(cid:12)

Type chem* Status  under
Dir 76/769**

Reg
793/93**
List 1-4

Status  under  Reg
793/93

Dir 
91/414**
Authorised in EU

Status  of  review  under
Dir 91/414

Dir 
Classification

67/548**

CASNR

Name

12789-
03-6

Chlordane

57-74-9

Chlordane (cis- and trans-)

143-50-0 Kepone (Chlordecone)

Pesticide

Pesticide

Pesticide

Pesticide

Mirex

2385-85-
5

8001-35-
2

50-29-3

Toxaphene = Camphechlor

Pesticide

DDT (technical) = clofenotane

Pesticide

50-29-3

p,p’-DDT = clofenotane

3563-45-
9

1,1,1,2-Tetrachloro-2,2-bis(4-
chlorophenyl)ethane (tetrachloro DDT)

Pesticide

Pesticide

16

NO

OBSOLETE in EU

As for Chlordane As for Chlordane

Carc.  Cat.  3;  R40;  Xn;
R21/22; N; R50-53

NO

NO

NO

NO

OBSOLETE,  suspended
worldwide

Carc.  Cat.  3;  R40;  T;
R24/25; N; R50-53

OBSOLETE,  suspended
worldwide

Carc. Cat. 3; R40;Repr.
Cat. 3; R62-63; R64

OBSOLETE,  suspended
worldwide

Carc.  Cat.  3;  R40;  T;
R25; Xn; R21

OBSOLETE

OBSOLETE

OBSOLETE

T;  R25-48/25;  Carc.
Cat. 3; R40; N; R50-53

T;  R25-48/25;  Carc.
Cat. 3; R40; N; R50-53

CASNR

Name

Type chem* Status  under
Dir 76/769**

Reg
793/93**
List 1-4

Status  under  Reg
793/93

Dir 
91/414**
Authorised in EU

Status  of  review  under
Dir 91/414

Dir 
Classification

67/548**

50471-
44-8

12427-
38-2

Vinclozolin

Pesticide

Maneb

Pesticide

137-42-8 Metam Natrium

Pesticide

137-26-8

Thiram

12122-
67-7

Zineb

Pesticide

Pesticide

58-89-9

Gamma-HCH (Lindane)

Pesticide

330-55-2

Linuron (Lorox)

Pesticide

IRL-UK-NL-BE-
LUXX-DE-AU-
FR-ES-PT-IT-
GR

SF-DK-IRL-UK-
NL-BE-LUXX-
DE-AU-FR-ES-
PT-IT-GR

IRL-UK-NL-BE-
DE-FR-ES-PT-
IT-GR

SF-DK-IRL-UK-
NL-BE-LUXX-
DE-AU-FR-ES-
PT-IT-GR

IRL-UK-NL-BE-
FR-ES-PT-IT-
GR

IRL-UK-NL-BE-
LUXX-FR-ES-
PT-IT-GR

SF-DK-IRL-UK-
NL-BE-LUXX-
AU-FR-ES-PT-
IT-GR

Review  ongoing  under
Reg 3600/92

Review  ongoing  under
Reg 3600/92

Xi; R37; R43;

Xn; R22; R31; C; R34

Not  a  priority  substance
in  first  or  second  list
Notified  for 
third
stage of the review prog.
under Reg 451/2000.

the 

Review  ongoing  under
Reg 3600/92

Muta. Cat. 3; R40; Xn;
R20/22; Xi; R36/37

Review  ongoing  under
Reg 3600/92

Xi; R37; R43;

Withdrawal  decided 
Decision 2000/801/EC.

in

T;  R23/24/25;  Xi;
R36/38; N; R50-53

Review  ongoing  under
Reg 3600/92

Carc.  Cat.  3;  R40;  Xn;
R22-48/22; N; R50-53

17

CASNR

Name

61-82-5

Amitrol = Aminotriazol

1912-24-
9

Atrazine

34256-
82-1

Acetochlor

15972-
60-8

Alachlor

1836-75-
5

Nitrofen

100-42-5

Styrene

Type chem* Status  under
Dir 76/769**

Reg
793/93**
List 1-4

Status  under  Reg
793/93

Dir 
91/414**
Authorised in EU

Status  of  review  under
Dir 91/414

Dir 
Classification

67/548**

Pesticide

Pesticide

Pesticide

Pesticide

Pesticide

All  MS  except
DK, SE, SF, A, I

Review  ongoing  under
Reg 3600/92

Carc.  Cat.  3;  R40;  Xn;
R48/22; N; R51-53

IRL-UK-NL-BE-
LUXX-FR-ES-
PT-IT-GR

Review  ongoing  under
Reg 3600/92

Carc.  Cat.  3;  R40;
Muta. Cat. 3; R40; Xn;
R20/22

ES

Not  a  priority  substance
in  first  or  second  list.
Notified  for 
third
stage of the review prog.
under Reg 451/2000

the 

Xn;  R20;  Xi;  R37/38;
R43

FR-ES-PT-IT-
GR

Review  ongoing  under
Reg 3600/92

Carc.  Cat.  3;  R40;  Xn;
R22; R43

NO

OBSOLETE,  suspended
worldwide

Carc.  Cat.  2;  R45;
Repr. Cat. 2;  R61; Xn;
R22

Industrial

1

discussion
ENV

HH 
ongoing; 
finished

R10;  Xn;  R20;  Xi;
R36/38

Carc.  Cat.  2;  R45;  T;
R48/25; N; R50-53

Xn;R22;  C;R34;  N;50-
53

118-74-1 Hexachlorobenzene (HCB)

Industrial

NO

OBSOLETE in EU

25154-
52-3

Phenol, nonyl-

Industrial

Proposal 
restrict

to

2

Final 
September 1999

report

18

CASNR

Name

Type chem* Status  under
Dir 76/769**

Reg
793/93**
List 1-4

Status  under  Reg
793/93

Dir 
91/414**
Authorised in EU

Status  of  review  under
Dir 91/414

Dir 
Classification

67/548**

[Repr.Cat.2;R61];
[Repr.Cat. 3;R62];

Repr.Cat.2:R60-61;
R53?

Rep.Cat 
2;R61;
Rep.Cat 3;R62; N;R50

Xi; R36/37/38; R43;

R33; N; R50-53;

85-68-7

Butylbenzylphthalate (BBP)

Industrial

Proposal 
restrict

to

3

117-81-7 Di-(2-ethylhexyl)phthalate (DEHP)

Industrial

Proposal 
restrict

to

2

Discussion
starting  end  of
2000

Final report 2001

84-74-2

Di-n-butylphthalate (DBP)

Industrial

Proposal 
restrict

to

1

Final 
October 2000

report

80-05-7

2,2-Bis(4-hydroxyphenyl)propan  = 
isopropylidenediphenol = Bisphenol A

4,4’-

Industrial

3

RA  Report  due
June 2001

1336-36-
3

PCB

Industrial

Ban

35065-
27-1

32774-
16-6

2437-79-
8

32598-
13-3

PCB 153 (2,2’,4,4’,5,5’-Hexachlorobiphenyl)

Industrial

Ban

PCB 169 (3,3’,4,4’,5,5’-Hexachlorobiphenyl)

Industrial

Ban

PCB 47 (2,2’,4,4’-Tetrachlorobiphenyl)

Industrial

Ban

PCB 77 (3,3’,4,4’-Tetrachlorobiphenyl)

Industrial

Ban

19

CASNR

Name

Type chem* Status  under
Dir 76/769**

Reg
793/93**
List 1-4

Status  under  Reg
793/93

Dir 
91/414**
Authorised in EU

Status  of  review  under
Dir 91/414

Dir 
Classification

67/548**

53469-
21-9

12672-
29-6

11097-
69-1

11096-
82-5

No  CAS
004

40321-
76-4

1746-01-
6

57117-
31-4

PCB Aroclor 1242

Industrial

Ban

PCB Aroclor 1248

Industrial

Ban

PCB Aroclor 1254

Industrial

Ban

PCB Aroclor 1260 (Clophen A60)

Industrial

Ban

PBBs = Brominated Flame retardants = PBB
(mixed group of 209 Congeners)

Industrial

Restricted

1,2,3,7,8-Pentachlorodibenzodioxin

2,3,7,8-Tetrachlorodibenzo-p-dioxin
(2,3,7,8-TCDD)

2,3,4,7,8-Pentachlorodibenzofuran
(2,3,4,7,8-PeCDF)

By-product
of 
waste
incineration

By-product
of 
waste
incineration

By-product
of 
waste
incineration

No  CAS Tributyltin compounds

Metal

Restricted

T;  R25-48/23/25;  Xn;

20

CASNR

Name

050

Type chem* Status  under
Dir 76/769**

Reg
793/93**
List 1-4

Status  under  Reg
793/93

Dir 
91/414**
Authorised in EU

Status  of  review  under
Dir 91/414

Dir 
Classification

67/548**

688-73-3

Tributyltin hydride

Metal

Restricted

56-35-9

26354-
18-7

No  CAS
100

4342-30-
7

4342-36-
3

4782-29-
0

36631-
23-9

85409-

Tributyltin oxide = bis(tributyltin) oxide

Metal

Restricted

2-propenoic  acid,  2-methyl-,  methyl  ester  =
Stannane, tributylmeacrylate

Metal

Restricted

Methoxyetylacrylate tinbutyltin, copolymer Metal

Restricted

Phenol, 2-[[(tributylstannyl)oxy]carbony

Metal

Restricted

Stannane, (benzoyloxy)tributyl-

Metal

Restricted

Stannane, [1,2-phenylenebis(carbonyloxy)

Metal

Restricted

Stannane, tributyl = Tributyltin naphtalate

Metal

Restricted

Stannane, tributyl-, mono(naphthenoyloxy

Metal

Restricted

21

R21; Xi; R36/38

T;  R25-48/23/25;  Xn;
R21; Xi; R36/38

T;  R25-48/23/25;  Xn;
R21; Xi; R36/38

T;  R25-48/23/25;  Xn;
R21; Xi; R36/38

CASNR

Name

Type chem* Status  under
Dir 76/769**

Reg
793/93**
List 1-4

Status  under  Reg
793/93

Dir 
91/414**
Authorised in EU

Status  of  review  under
Dir 91/414

Dir 
Classification

67/548**

17-2

24124-
25-2

3090-35-
5

26239-
64-5

1983-10-
4

2155-70-
6

No  CAS
099

26636-
32-8

No  CAS
101

Stannane, tributyl[(1-oxo-9,12-octadecad

Metal

Restricted

Stannane, tributyl[(1-oxo-9-octadecenyl)

Metal

Restricted

Stannane, tributyl[[[1,2,3,4,4a,4b,5,6,1

Metal

Restricted

Stannane, tributylfluoro-

Metal

Restricted

Tributyl[(2-methyl-1-oxo-2-
propenyl)oxy]stannane

Metal

Restricted

Tributyltincarboxylate

Metal

Restricted

Tributyltinnaphthalate

Metal

Restricted

Tributyltinpolyethoxylate

Metal

Restricted

2279-76-

Tri-n-propyltin (TPrT)

Metal

Restricted

22

T;  R25-48/23/25;  Xn;
R21; Xi; R36/38

T;  R25-48/23/25;  Xn;
R21; Xi; R36/38

T;  R25-48/23/25;  Xn;
R21; Xi; R36/38

CASNR

Name

Type chem* Status  under
Dir 76/769**

Reg
793/93**
List 1-4

Status  under  Reg
793/93

Dir 
91/414**
Authorised in EU

Status  of  review  under
Dir 91/414

Dir 
Classification

67/548**

Tetrabutyltin (TTBT)

Metal

Restricted

Triphenyltin

Metal

Restricted

T;R23/24/25;N;R5053;

7

1461-25-
2

No  CAS
051

900-95-8

Fentin acetate = triphenyltin acetate

Metal

95-76-1

3,4-Dichloroaniline

10605-
21-7

Carbendazim

309-00-2 Aldrin

60-57-1

Dieldrin

115-29-7

Endosulfan

959-98-8

Endosulfan (alpha)

Other
substance

Pesticide

Pesticide

Pesticide

Pesticide

Pesticide

IRL-UK-NL-BE-
LUXX-DE-AU-
FR-PT-IT-GR

Review  ongoing  under
Reg 3600/92

T+;  R26;  T;  R24/25;
Xi; R36/38

1

Final  report  end
of 2000

T;  R23/24/25;  R33;  N;
R50-53

All  MS  except
SF

Review  ongoing  under
Reg 3600/92

Muta. Cat. 3; R40

NO

NO

OBSOLETE,  suspended
worldwide

T;  R24/25-48/24/25;
Carc.  Cat.  3;  R40;  N;
R50-53

OBSOLETE,  suspended
worldwide

T+;  R27;  T;  R25-
48/25;  Carc.  Cat.  3;
R40

All  MS  except
SE, DK, NL, DE

Review  ongoing  under
Reg 3600/92

T; R24/25; Xi; R36; N;
R50-53

As 

for As for Endosulfan

23

CASNR

Name

Type chem* Status  under
Dir 76/769**

Reg
793/93**
List 1-4

Status  under  Reg
793/93

Dir 
91/414**
Authorised in EU

Status  of  review  under
Dir 91/414

Dir 
Classification

67/548**

Endosulfan

As 
Endosulfan

NO

for

As for Endosulfan

OBSOLETE,  suspended
worldwide

T+;  R28;  T;  R24;  N,
R50-53

As for chlordane As for chlordane

As for Mirex

As for Mirex

33213-
65-9

Endosulfan (beta)

Pesticide

Pesticide

Pesticide

Pesticide

72-20-8

Endrin

Oxychlordane

Photomirex

27304-
13-8

39801-
14-4

94-75-7

67747-
09-5

2,4-Dichlorophenoxy acetic acid (2,4-D)

Pesticide

ALL  MS,  except
SE

Review  ongoing  under
Reg 3600/92

Xn; 
R36/37/38;

R22; 

Xi;

Prochloraz

Pesticide

All MS

Xn; R22; N; R50-53;

Not  a  priority  substance
in  first  or  second  list.
Notified  for 
third
stage of the review prog.
under Reg 451/2000

the 

115-32-2 Dicofol = Kelthane

Pesticide

36734-
19-7

Iprodione

Pesticide

IR, UK, NL, BE,
LUX,  AU,  FR,
ES, IT, PT

Not in first or second list.
Notified  for 
third
stage  of  the  review  prog
under Reg 451/2000

the 

Xn;  R21/22;  Xi;  R38;
R43

All MS

Review  ongoing  under
Reg 3600/92

24

Type chem* Status  under
Dir 76/769**

Reg
793/93**
List 1-4

Status  under  Reg
793/93

Dir 
91/414**
Authorised in EU

Status  of  review  under
Dir 91/414

Dir 
Classification

67/548**

CASNR

Name

137-30-4

Ziram

330-54-1 Diuron

333-41-5 Diazinon

60-51-5

Dimethoate

121-75-5 Malathion

298-00-0 Methylparathion

Pesticide

Pesticide

Pesticide

Pesticide

Pesticide

Pesticide

56-38-2

Parathion = Parathion(-ethyl)

Pesticide

122-34-9

Simazine

43121-
43-3

Triadimefon

Pesticide

Pesticide

25

All  MS  except
SF, SE, IRL, DE

Review  ongoing  under
Reg 3600/92

Muta. Cat. 3; R40; Xn;
R22; Xi; R36/37/38

All  MS  except
SE, SF

Second  list  of  priority
substances 
under
Regulation 451/2000

Carc.  Cat.  3;  R40;
Muta. Cat. 3; R40; Xn;
R22-48/22

All MS

All MS

Second  list  of  priority
substances 
under
Regulation 451/2000

Xn; R22; N; R50-53;

Second  list  of  priority
substances 
under
Regulation 451/2000

Xn; R21/22

All  MS  except
SE, DE, AU

Second  list  of  priority
sub under Reg. 451/2000

Xn; R22

NL,  LUXX,  DE,
AU,  FR,  ES,  IT,
GR

NL,  BE,  LUXX,
DE,  FR,  ES,  IT,
GR

Review  ongoing  under
Reg 3600/92

T+; R28; T; R24;

Review  ongoing  under
Reg 3600/92

T+;  R27/28;  N;  R50-
53;

All  MS  except
SE and DE

Review  ongoing  under
Reg 3600/92

Carc. Cat. 3; R40

All  MS  except
DK

Not  a  priority  substance
in  first  or  second  list.
Notified  for 
third
stage of the review prog.

the 

Xn; R22; N; R51-53;

CASNR

Name

Type chem* Status  under
Dir 76/769**

Reg
793/93**
List 1-4

Status  under  Reg
793/93

Dir 
91/414**
Authorised in EU

Status  of  review  under
Dir 91/414

Dir 
Classification

67/548**

76-44-8

Heptachlor

Pesticide

74-83-9

Methylbromide (bromomethane)

Pesticide

709-98-8

Propanil

Pesticide

1570-64-
5

4-chloro-2-methylphenol

Industrial

98-54-4

4-tert-Butylphenol

Diisodecyl phthalate

Industrial

Industrial

under Reg 451/2000

NO

Obsolete in EU

All  MS  except
LUXX

FR,  IT,  ES,  PT,
GR

Not  a  priority  substance
in  first  or  second  list.
third
Notified  for 
stage of the review prog.
under Reg 451/2000

the 

Not  a  priority  substance
in  first  or  second  list.
Notified  for 
third
stage of the review prog.
under Reg 451/2000

the 

T;  R24/25;  Carc.  Cat.
3; R40; R33

Muta.  Cat.  3;  R40;  T;
R23/25; Xn; R48/20

Xn; R22

Final 
August 1999

report

T;  R23;  C;  R35;  N;
R50

1

4

Proposal 
restrict

to

2

Final  report  first
half 2001

26761-
40-0

28553-
12-0

38411-

diisononyl 
dicarboxylic acid, diisononyl ester (DINP)

phthalate 

1,2-Benzene

= 

Industrial

Proposal 
restrict

to

2

Final  report  first
half 2001

PCB 136 (2,2’,3,3’,6,6’-Hexachlorobiphenyl)

Industrial

Ban

26

CASNR

Name

Type chem* Status  under
Dir 76/769**

Reg
793/93**
List 1-4

Status  under  Reg
793/93

Dir 
91/414**
Authorised in EU

Status  of  review  under
Dir 91/414

Dir 
Classification

67/548**

22-2

38380-
08-4

70362-
47-9

33284-
53-6

32598-
12-2

No  CAS
044

No  CAS
043

No  CAS
045

107555-
93-1

PCB 156 (2,3,3’,4,4’,5-Hexachlorobiphenyl)

Industrial

Ban

PCB 48 (2,2’,4,5-Tetrachlorobiphenyl)

Industrial

Ban

PCB 61 (2,3,4,5-Tetrachlorobiphenyl)

Industrial

Ban

PCB 75 (2,4,4’,6-Tetrachlorobiphenyl)

Industrial

Ban

Decabrominated diphenyl ether (decaBDE)

Industrial

Octabrominated diphenyl ether (octaBDE)

Industrial

1

1

Pentabrominated diphenyl ether (pentaBDE)

Industrial

Proposed ban 2

1,2,3,7,8-Pentabromodibenzofuran

By-product
waste
of 
incineration

27

CASNR

Name

Type chem* Status  under
Dir 76/769**

Reg
793/93**
List 1-4

Status  under  Reg
793/93

Dir 
91/414**
Authorised in EU

Status  of  review  under
Dir 91/414

Dir 
Classification

67/548**

57117-
41-6

83704-
53-4

58802-
20-3

71998-
72-6

67733-
57-7

51207-
31-9

106340-
44-7

1,2,3,7,8-Pentachlorodibenzofuran

1,2,3,7,9-Pentachlorodibenzofuran

1,2,7,8-Tetrachlorodibenzofuran

1,3,6,8-Tetrachlorodibenzofuran

2,3,7,8-Tetrabromodibenzofuran

2,3,7,8-Tetrachlorodibenzofuran

Tetrabromodibenzofuran (TeBDF)

127-18-4

Perchloroethylene

By-product
of 
waste
incineration

By-product
of 
waste
incineration

By-product
of 
waste
incineration

By-product
of 
waste
incineration

By-product
of 
waste
incineration

By-product
of 
waste
incineration

By-product
of 
waste
incineration

Other
substance

1

discussion
ENV

HH 
ongoing. 
finished.

Carc.  Cat.  3;  R40;  N;
[Repr.
R51-53; 
Cat.3;R62]

28

CASNR

Name

Type chem* Status  under
Dir 76/769**

Reg
793/93**
List 1-4

Status  under  Reg
793/93

Dir 
91/414**
Authorised in EU

Status  of  review  under
Dir 91/414

Dir 
Classification

67/548**

 Oestradiol  17  beta  and 
derivatives***

its  ester-like

Progesterone***

Testosterone***

Melengestrol acetate (MGA)***

Trenbolone***

Zeranol***

or
to

Natural 
identical 
natural
hormone

As above

As above

Synthetic
hormone

Synthetic
hormone

Synthetic
hormone

* Substances are broadly grouped into industrial chemicals, pesticides, metals, other substances and natural/synthetic hormones.

**
Dir 76/769 = Directive 76/769/EEC relating to restrictions on marketing and use of certain dangerous substances and preparations
Reg 793/93 =Regulation (EEC) No.793/93 for Risk Assessment of Existing Substances
Dir 91/414 = Directive 91/414/EEC concerning the placing on the market of Plant Protection Products
Dir 67/548 = Directive 67/548/EEC on classification, packaging and labelling of dangerous substances

*** Restricted under Directive 96/22/EEC  concerning  the  prohibition on  the use  in stock-farming of  certain substances having a hormonal or
thyrostatic action and beta-agonists.

29

7DEOH(cid:3)(cid:23)(cid:29)

6XEVWDQFHV(cid:3)ZLWK(cid:3)LQVXIILFLHQW(cid:3)GDWD(cid:3)LQ(cid:3)WKH(cid:3)%.+(cid:3)5HSRUW(cid:3)(cid:11) (cid:3)(cid:23)(cid:22)(cid:24)(cid:12)

29082-74-4

Octachlorostyrene (chemno 190)

11081-15-5

Phenol, isooctyl- (chemno 253)

119-61-9

Benzophenone (chemno 541)

68-12-2

Dimethylformamide (DMFA) (chemno 545)

106-93-4

Dibromoethane (EDB) (chemno 169)

106-89-8

Epichlorohydrin (1-chloro-2,3-epoxypropane) (chemno 348)

35693-99-3

PCB 52 (2,2’;5,5’-Tetrachlorobiphenyl) (chemno 419)

3734-48-3

Chlordene (chemno 13)

39765-80-5

Trans-Nonachlor (chemno 25)

1024-57-3

Heptachlor-epoxide (chemno 177)

4685-14-7

Paraquat = 1,1’-dimethyl-4,4’-bipyridinium (chemno 183)

103-23-1

Bis(2-ethylhexyl)adipate (chemno 277)

84-61-7

Dicyclohexyl phthalate (DCHP) (chemno 280)

84-66-2

Diethyl phthalate (DEP) (chemno 281)

92-52-4

Diphenyl (chemno 370)

38380-07-3

PCB 128 (2,2’,3,3’,4,4’-Hexachlorobiphenyl) (chemno 405)

135-19-3

2-Naphthol (chemno 444)

108-05-4

Vinyl acetate (chemno 564)

17804-35-2

Benomyl (chemno 1)

116-06-3

Aldicarb (chemno 3)

63-25-2

Carbaryl (chemno 5)

1563-66-2

Carbofuran (chemno 6)

72490-01-8

Fenoxycarb (chemno 7)

16752-77-5

Methomyl (chemno 8)

93-76-5

2,4,5-T = 2,4,5-Trichlorophenoxyaceticacid (chemno 26)

69806-50-4

Fluazifop-butyl (chemno 28)

76578-14-8

Quizalofop-ethyl (chemno 30)

2971-22-4

1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (chemno 31)

34113-46-7

o,p’-DDA (chemno 46)

53-19-0

o,p’-DDD (chemno 48)

3424-82-6

o,p’-DDE (chemno 49)

30

14835-94-0

o,p’-DDMU (chemno 50)

789-02-6

o,p’-DDT (chemno 51)

72-54-8

p,p’-DDD (chemno 53)

72-55-9

p,p’-DDE (chemno 54)

3563-45-9

Tetrachloro DDT = 1,1,1,2-Tetrachloro-2,2-bis(4-chlorophenyl)ethane (chemno 58)

32809-16-8

Procymidon (chemno 62)

40487-42-1

Pendimethalin (chemno 64)

29091-21-2

Prodiamine (chemno 65)

1582-09-8

Trifluralin (chemno 66)

79-44-7

Dimethyl carbamyl chloride (chemno 67)

8018-01-7

Mancozeb (chemno 68)

9006-42-2

Metiram (Metiram-complex) (chemno 71)

142-59-6

Nabam (chemno 72)

319-85-7

Beta-HCH (chemno 76)

319-86-8

Delta-HCH (chemno 77)

608-73-1

Hexachlorocyclohexane = HCH mixed (chemno 79)

1689-84-5

Bromoxynil (chemno 80)

1689-83-4

Ioxynil (chemno 81)

3567-62-2

1-(3,4-Dichlorophenyl)-3-methylurea (chemno 83)

35367-38-5

Diflubenzuron (chemno 84)

96-45-7

Ethylene Thiourea (ETU) (chemno 86)

14868-03-2

Bis-OH-MDDE (chemno 90)

2971-36-0

Bis-OH-Methoxychlor = 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (HTPE) (chemno 91)

2132-70-9

MDDE (chemno 92)

72-43-5

Methoxychlor (chemno 93)

72-43-5

p,p’-Methoxychlor (chemno 96)

30560-19-1

Acephate (chemno 98)

470-90-6

Chlorfenvinphos (chemno 99)

2921-88-2

Chlorpyrifos (chemno 100)

50-18-0

Cyclophosphamide (chemno 101)

682-80-4

Demefion (chemno 102)

919-86-8

Demeton-s-methyl (chemno 103)

31

62-73-7

Dichlorvos (chemno 105)

2597-03-7

Elsan = Dimephenthoate (chemno 107)

122-14-5

Fenitrothion (chemno 108)

2540-82-1

Formothion (chemno 110)

51276-47-2

Glufosinate (chemno 111)

7786-34-7

Mevinphos = Phosdrin (chemno 116)

1113-02-6

Omethoate (chemno 117)

301-12-2

Oxydemeton-methyl (chemno 118)

13171-21-6

Phosophamidon (chemno 120)

13593-03-8

Quinalphos = Chinalphos (chemno 121)

299-84-3

Ronnel = fenchlorfos (chemno 122)

22248-79-9

Tetrachlorvinphos = Gardona (chemno 123)

52-68-6

Trichlorfon = Dipterex (chemno 124)

82657-04-3

Bifenthrin (@Talstar) (chemno 126)

584-79-2

Bioallethrin = d- trans allethrin (chemno 127)

91465-08-6

Cyhalothrin (@Karate) (chemno 128)

52315-07-8

Cypermethrin (chemno 129)

52918-63-5

Deltamethrin (chemno 130)

66230-04-4

Esfenvalerate (chemno 131)

26002-80-2

Fenothrin = sumithrin (chemno 132)

51630-58-1

Fenvalerate (chemno 133)

69409-94-5

Fluvalinate (chemno 134)

52645-53-1

Permethrin (chemno 135)

10453-86-8

Resmethrin (chemno 136)

314-40-9

Bromacil (chemno 138)

60168-88-9

Fenarimol (chemno 139)

1918-02-1

Picloram (chemno 140)

21725-46-2

Cyanazine (chemno 144)

94361-07-6

Cyproconazole (chemno 145)

119446-68-3

Difenoconazole (chemno 146)

2593-15-9

Etridiazole (chemno 149)

65277-42-1

Ketoconazol (chemno 152)

32

21087-64-9

Metribuzin (chemno 153)

66246-88-6

Penconazole (chemno 154)

60207-90-1

Propiconazole (chemno 155)

107534-96-3

Tebuconazole (chemno 157)

886-50-0

Terbutryn (chemno 158)

123-88-6

Triadimenol (chemno 160)

33089-61-1

Amitraz (chemno 165)

6164-98-3

Chlordimeform (chemno 166)

74115-24-5

Clofentezine = chlorfentezine (chemno 167)

96-12-8

Dibromochloropropane (DBCP) (chemno 168)

25550-58-7

Dinitrophenol (chemno 170)

88-85-7

Dinoseb (chemno 171)

80844-07-1

Ethofenprox (chemno 172)

76674-21-0

Flutriafol (chemno 174)

2439-99-8

Glyphosate (chemno 175)

2212-67-1

Molinate (chemno 180)

88671-89-0

Myclobutanil (chemno 181)

82-68-8

Pentachloronitrobenzene (PCNB) (chemno 184)

51-03-6

Piperonyl butoxide (chemno 185)

7287-19-6

Prometryn (chemno 186)

104-51-8

n-Butylbenzene (chemno 189)

12002-48-1

Trichlorobenzene (chemno 193)

25167-81-1

Dichlorophenol (chemno 197)

608-93-5

Pentachlorobenzene (chemno 199)

87-86-5

Pentachlorophenol (PCP) (chemno 200)

87-26-3

2-sec-Pentylphenol = 2-(1-Methylbutyl)phenol (chemno 201)

1131-60-8

4-Cyclohexylphenol (chemno 203)

1009-11-6

4-Hydroxy-n-butyrophenone (chemno 205)

70-70-2

4-Hydroxypropiophenone (chemno 206)

104-40-5

4-Nonylphenol (4-NP) (chemno 208)

20427-84-3

4-Nonylphenoldiethoxylate (NP2EO) (chemno 209)

3115-49-9

4-nonylphenoxy acetic acid (chemno 211)

33

99-71-8

4-sec-Butylphenol = 4-(1-Methylpropyl)phenol (chemno 213)

94-06-4

4-sec-Pentylphenol = 4-(1-Methylbutyl)phenol = p-sec-amylphenol (chemno 214)

7786-61-0

4-vinylguaiacol (4-VG) (chemno 218)

2628-17-3

4-vinylphenol (4-VP) (chemno 219)

27986-36-3

Ethanol, 2-(nonylphenoxy)- (chemno 220)

1322-97-0

Ethanol, 2-(octylphenoxy)- = Octylphenolethoxylate (chemno 221)

9036-19-5

Glycols,  polyethylene,  mono((1,1,3,3-tet  =  Poly(oxy-1,2-ethanediyl), 
tetramethylbutyl)phenyl]-.omega.-hydroxy- (chemno 223)

.alpha.-[(1,1,3,3-

9002-93-1

Glycols,  polyethylene,  mono(p-(1,1,3,3-t  =  Octoxynol  =  Poly(oxy-1,2-ethanediyl),  alpha-(4-
(1.1.3.3.-tetramethyl-butyl)phenyl)-omega-hydroxy- (chemno 224)

26027-38-3

Glycols, polyethylene, mono(p-nonylpheny (chemno 225)

9016-45-9

Nonylphenolethoxylate (chemno 229)

27193-28-8

Phenol, (1,1,3,3-tetramethylbutyl)- = Octylphenol (chemno 238)

27985-70-2

Phenol, (1-methylheptyl)- (chemno 239)

3884-95-5

Phenol, 2-(1,1,3,3-tetramethylbutyl)- (chemno 241)

17404-44-3

Phenol, 2-(1-ethylhexyl)- (chemno 242)

18626-98-7

Phenol, 2-(1-methylheptyl)- (chemno 243)

37631-10-0

Phenol, 2-(1-propylpentyl)- (chemno 244)

949-13-3

Phenol, 2-octyl- (chemno 245)

3307-00-4

Phenol, 4-(1-ethylhexyl)- (chemno 247)

1818-08-2

Phenol, 4-(1-methylheptyl)- (chemno 248)

3307-01-5

Phenol, 4-(1-propylpentyl)- (chemno 249)

1806-26-4

Phenol, 4-octyl- (chemno 251)

51811-79-1

Poly(oxy-1,2-ethanediyl), alpha-(nonylphenyl)-omega-hydroxy-forgrenet (chemno 262)

9014-90-8

Poly(oxy-1,2-ethanediyl), alpha-sulfo-omega-nonylphenoxy (chemno 267)

25013-16-5

tert.-Butylhydroxyanisole (BHA) (chemno 271)

117-84-0

1,2-Benzenedicarboxylic acid, dioctyl ester (chemno 276)

84-75-3

Di-n-hexyl phthalate (DnHP) = Dihexylphthalate (DHP) (chemno 287)

131-18-0

Di-n-pentylphthalate (DPP) = Dipentylphthalate (chemno 289)

131-16-8

Di-n-propylphthalate (DprP) = Dipropylphthalate (chemno 290)

4376-20-9

Mono 2 ethyl hexylphthalate (MEHP) (chemno 291)

131-70-4

Mono-n-butylphthalate (chemno 292)

33204-76-1

2,6-cis-Diphenylhexamethylcyclotetrasiloxane  -  2,6-cis-[(PhMeSiO)2(Me2SiO)2][  (chemno

34

295)

30026-85-8

Diphenylhexamethylcyclotetrasiloxane [(PhMeSiO)2(Me2SiO)2] (chemno 297)

56-33-7

Diphenyltetramethyldisiloxane PhMe2-SiOSiMe2Ph (chemno 299)

10448-09-6

Phenylheptamethylcyclotetrasiloxane [(PhMeSiO)(Me2SiO)3] (chemno 301)

28994-41-4

Phenyl-2-hydroxyphenylmethane = 2-Benzylphenol = o-Benzylphenol (chemno 304)

101-53-1

Phenyl-4-hydroxyphenylmethane = 4-Benzylphenol = p-Benzylphenol (chemno 305)

2081-08-5

1,1-Bis(4-hydroxyphenyl)ethane (chemno 308)

2081-32-5

1,1-Bis(4-hydroxyphenyl)-iso-pentane (chemno 310)

4731-84-4

1,1-Bis(4-hydroxyphenyl)-n-butane (chemno 311)

3373-03-3

1,1-Bis(4-hydroxyphenyl)-n-heptane (chemno 312)

24362-98-9

1,1-Bis(4-hydroxyphenyl)-n-hexane (chemno 313)

1576-13-2

1,1-Bis(4-hydroxyphenyl)-n-propane (chemno 314)

25036-25-3

2,2’-bis(2-(2,3-epoxypropoxy)phenyl)-propane (chemno 317)

6807-17-6

2,2-Bis(4-hydroxyphenyl)-4-methyl-n-pentane (chemno 320)

77-40-7

2,2-Bis(4-hydroxyphenyl)-n-butan = Bisphenol B (chemno 321)

14007-30-8

2,2-Bis(4-hydroxyphenyl)-n-hexane (chemno 323)

131-54-4

2,2’-Dihydroxy-4,4’-dimethoxybenzophenon (chemno 327)

52479-85-3

2,3,4,3’,4’,5’-Hexahydroxybenzophenon (chemno 328)

131-56-6

2,4-Dihydroxybenzophenon = Resbenzophenone (chemno 330)

611-99-4

4,4’-Dihydroxybenzophenon (chemno 335)

620-92-8

Bis(4-hydroxyphenyl)methane (chemno 340)

25085-99-8

Bisphenol A-diglycidylether polymer (mw<700) (chemno 343)

81-92-5

2-[Bis(4-hydroxyphenyl)methyl]benzylalkohol = Phenolphthalol (chemno 355)

77-09-8

3,3’-Bis(4-hydroxyphenyl)phthalid = Phenolphthaleine (chemno 356)

4081-02-1

Bis(4-Hydroxyphenyl)phenylmethane (chemno 360)

1806-29-7

2,2’-Dihydroxybiphenyl = 2,2’-Biphenol (chemno 367)

92-88-6

4,4’-Dihydroxybiphenyl = 4,4’-Biphenol (chemno 368)

92-69-3

4-Hydroxybiphenyl = 4-Phenylphenol (chemno 369)

53905-30-9

2-Hydroxy-2’,5’-dichlorobiphenyl (chemno 374)

53905-29-6

3-Hydroxy-2’,5’-dichlorobiphenyl (chemno 378)

53905-28-5

4-Hydroxy-2’,5’-dichlorobiphenyl (chemno 385)

23719-22-4

4-Hydroxy-2-chlorobiphenyl (chemno 387)

35

4400-06-0

4-Hydroxy-3,4’,5-trichlorobiphenyl (chemno 389)

28034-99-3

4-Hydroxy-4’-chlorobiphenyl (chemno 391)

2051-60-7

PCB 1 (2-Chlorobiphenyl) (chemno 397)

2050-67-1

PCB 11 (3,3’-Dichlorobiphenyl) (chemno 400)

2050-68-2

PCB 15 (4,4’-Dichlorobiphenyl) (chemno 407)

37680-65-2

PCB 18 (2,2’,5-Trichlorobiphenyl) (chemno 411)

2051-61-8

PCB 2 (3-Chlorobiphenyl) (chemno 412)

55702-46-0

PCB 21 (2,3,4-Trichlorobiphenyl) (chemno 413)

2051-62-9

PCB 3 (4-Chlorobiphenyl) (chemno 415)

13029-08-8

PCB 4 (2,2’-Dichlorobiphenyl) (chemno 416)

34883-43-7

PCB 8 (2,4’-Dichlorobiphenyl) (chemno 423)

11104-28-2

PCB Aroclor 1221 (chemno 425)

11141-16-5

PCB Aroclor 1232 (chemno 426)

90-15-3

1-Naphthol (chemno 442)

1125-78-6

5,6,7,8-Tetrahydro-2-naphthol = 6-Hydroxytetralin (chemno 445)

15231-91-1

6-Bromo-2-naphthol (chemno 446)

530-91-6

Tetrahydronaphthol-2 (chemno 449)

56-49-5

3-Methylcholanthrene (chemno 455)

57-97-6

7,12-Dimethyl-1,2-benz(a)anthracene (chemno 457)

56-55-3

Benz(a)anthracene (chemno 461)

50-32-8

Benzo[a]pyrene (chemno 462)

53-96-3

n-2-fluorenylacetamide (chemno 464)

109333-34-8

1,2,3,7,8-PeBDD (chemno 466)

50585-46-1

1,3,7,8-Tetrachlorodibenzodioxin (chemno 470)

50585-41-6

2,3,7,8-TeBDD (chemno 471)

50585-40-5

2,3-Dibromo-7,8-dichlorodibenzodioxin (chemno 473)

103456-39-9

TeBDD (chemno 481)

303-38-8

2,3-dihydroxybenzoicacid (2,3-DHBA) (chemno 533)

94-82-6

2,4-dichlorophenoxybutyric acid = 2,4-DB (chemno 534)

490-79-9

2,5-dihydroxybenzoicacid (2,5-DHBA) (chemno 535)

106-47-8

4-chloroaniline (chemno 537)

57-12-5

Cyanide (chemno 544)

36

482-49-5

Doisynolic acid (chemno 546)

64529-56-2

Ethiozin (chemno 547)

537-98-4

Ferulic acid (FA) (chemno 549)

533-73-3

Hydroxyhydroquinone (chemno 551)

72-33-3

Mestranol (chemno 553)

19044-88-3

Oryzalin (chemno 555)

7400-08-0

p-Coumaric acid (PCA) (chemno 556)

23950-58-5

Pronamide (chemno 559)

463-56-9

Thiocyanate (chemno 563)

No CAS 001

Carbamate (chemno 4)

2597-11-7

1-Hydroxychlordene (chemno 9)

No CAS 002

Cis-Nonachlor (chemno 14)

65148-76-7

3-MeO-o,p’-DDA (chemno 32)

65148-80-3

3-MeO-o,p’-DDE (chemno 33)

43216-70-2

3-OH-o,p’-DDT (chemno 34)

65148-81-4

4-MeO-o,p’-DDE (chemno 35)

65148-72-3

4-MeO-o,p’-DDT (chemno 36)

65148-77-8

5-MeO-o,p’-DDA (chemno 37)

65148-75-6

5-MeO-o,p’-DDD (chemno 38)

65148-82-5

5-MeO-o,p’-DDE (chemno 39)

65148-74-5

5-MeO-o,p’-DDT (chemno 40)

65148-73-4

5-OH-o,p’-DDT (chemno 41)

No CAS 003

DDT metabolites (chemno 43)

4329-12-8

m,p’-DDD (chemno 45)

65148-83-6

o,p’-DDA-glycinat = N-[(2-chlorophenyl)(4-chlorophenyl)acettyl]glycin (chemno 47)

No CAS 084

p,p’-DDA (chemno 52)

No CAS 085

p,p’-DDMU (chemno 55)

88378-55-6

3,5-Dichlorophenylcarbaminacid-(1-carboxy-1-methyl)-allyl (chemno 59)

83792-61-4

N-(3,5-Dichlorophenyl)-2-hydroxy-2-methyl-3-butenacidamid (chemno 61)

17356-61-5

1-(3,4-Dichlorophenyl)-3-methoxyurea (chemno 82)

No CAS 096

1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (HPTE) (chemno 88)

30668-06-5

1,3-Dichloro-2,2-bis(4-methoxy-3-methylphenyl)propane (chemno 89)

37

75938-34-0

Mono-OH-MDDE (chemno 94)

28463-03-8

Mono-OH-Methoxychlor (chemno 95)

No CAS 108

1-methyl-2-methylcarbamoylvinyldimethyl phosphate (chemno 97)

70393-85-0

Glufosinate-ammonium (chemno 112)

No CAS 122

Metalodemeton (chemno 114)

No CAS 005

Pyrethrin (chemno 125)

No CAS 123

Synthetic pyrethroids (chemno 137)

No CAS 120

Bitertanol (chemno 143)

No CAS 121

Epiconazol (chemno 147)

No CAS 008

Epoxiconazole (chemno 148)

No CAS 130

Febuconazole (chemno 150)

No CAS 009

Indole(3.2-b)carbazole (ICZ) (chemno 151)

No CAS 007

Triazines (e.g. atrazine) (chemno 161)

71751-41-2

Abamectin (chemno 162)

No CAS 132

Fipronil (chemno 173)

3555-44-0

Imazalil (chemno 178)

NO CAS 129

Thiazopyr (chemno 188)

No CAS 010

Styrenes (e.g. dimers and trimers) (chemno 192)

53792-11-3

4-(4-Hydroxyphenyl)-2,2,6,6-tetramethylcyclohexanecarbonacid (chemno 202)

No CAS 133

4-hydroxy alkylphenol (chemno 204)

1805-61-4

4-iso-Pentylphenol = 4-(3-Methylbutyl)phenol (chemno 207)

14409-72-4

4-Nonylphenolnonaethoxylat (Tergitol NP 9) (chemno 210)

No CAS 016

4-Nonylphenoxycarboxylic acid (NP1EC) (chemno 212)

No CAS 013

4-tert-Pentylphenol = p-tert-Amylphenol (chemno 217)

9040-65-7

Formaldehyde, polymere with nonylphenol (chemno 222)

2717-05-5

Heptaoctatrikosan-1-ol, 
(chemno 226)

23-(nonylphenoxy)3,6,9,12,15,18,21-nonylphenolmonoethoxylate

No CAS 102

malein..anhydride, monoester with ethoxylated nonylphenol, nutrilized with reaction products
like dipropylenetriamine (chemno 227)

No CAS 015

Nonylphenolcarboxylic acid (chemno 228)

No CAS 017

Nonylphenolethoxylate carboxylic acid (chemno 230)

No CAS 104

nonylphenolethoxylate with 9<EO<19 (chemno 231)

No CAS 103

nonylphenolethoxylate with EO<9 (chemno 232)

38

No CAS 105

nonylphenolethoxylate with EO>19 (chemno 233)

No CAS 106

nonylphenolethyleneoxyphosphate (chemno 234)

No CAS 014

Octylphenol-5-ethoxylate (chemno 235)

9004-87-9

OP-7 = Poly(oxy-1,2-ethanediyl), alpha-(iso-octylphenyl)-omega-hydroxy- (chemno 236)

No CAS 012

Penta to Nonyl-Phenols (chemno 237)

1331-54-0

Phenol, (2-ethylhexyl)- (chemno 240)

26401-75-2

Phenol, 2-sec-octyl- (chemno 246)

27013-89-4

Phenol, 4-isooctyl- (chemno 250)

27214-47-7

Phenol, 4-sec-octyl- (chemno 252)

67554-50-1

Phenol, octyl- (chemno 255)

93891-78-2

Phenol, sec-octyl- (chemno 256)

52623-95-7

Poly(oxy-1,2-ethanediyl), 
phosphate (chemno 257)

alpha-((1.1.3.3.-tetramethyl-butyl)phenyl)-omega-hydroxy-

81642-15-1

Poly(oxy-1,2-ethanediyl), alpha-(3-octylphenyl)-omega-hydroxy (chemno 258)

51651-58-2

Poly(oxy-1,2-ethanediyl), alpha-(4-isooctylphenyl)-omega-hydroxy- (chemno 259)

68891-21-4

Poly(oxy-1,2-ethanediyl), alpha-(dinonylphenyl)-omega-hydroxy-forgrenet (chemno 260)

37205-87-1

Poly(oxy-1,2-ethanediyl), alpha-(iso-nonylphenyl)-omega-hydroxy-phosphate (chemno 261)

68412-54-4

Poly(oxy-1,2-ethanediyl), alpha-(nonylphenyl)-omega-hydroxy-forgrenet (chemno 263)

9036-89-2

Poly(oxy-1,2-ethanediyl), alpha-(octylphenyl)-omega-hydroxy- (chemno 264)

68987-90-6

Poly(oxy-1,2-ethanediyl), alpha-(octylphenyl)-omega-hydroxy-forgrenet (chemno 265)

60864-33-7

Poly(oxy-1,2-ethanediyl),  alpha-(phenylmethyl)-omega-((1.1.3.3.-tetramethyl-butyl)-phenoxy)
(chemno 266)

55348-40-8

Poly(oxy-1,2-ethanediyl), 
(chemno 268)

109909-39-9

Poly(oxy-1,2-ethanediyl), 
salt (chemno 269)

alpha-sulpho-omega-((1.1.3.3.-tetramethyl-butyl)-phenoxy)

alpha-sulpho-omega(2,4,6-tris(1-methylpropyl)phenoxy)-sodium

69011-84-3

Poly(oxy-1,2-ethanediyl),  alpha-sulpho-omega-(octylphenyl)-forgrenet,  sodium  salt  (chemno
270)

No CAS 020

Intermediate chain chlorinated parafins (chemno 272)

No CAS 021

Long chain chlorinated parafins (chemno 273)

No CAS 019

Short chain chlorinated parafins (chemno 274)

89-69-5

Diisobutylphthalate (chemno 282)

No CAS 024

Dioctylphthalate (DOP) (chemno 285)

No CAS 022

Di-n-octylphthalate (DnOP) (chemno 288)

No CAS 023

Phthalates (chemno 293)

39

31751-59-4

2,4-trans-Diphenyltetramethylcyclotrisiloxane  -  2,4-trans-[(PhMeSiO)2(Me2SiO)]  (chemno
294)

33204-77-2

2,6-trans-Diphenylhexamethylcyclotetrasiloxane 
(chemno 296)

- 

2,6-trans-[(PhMeSiO)2(Me2SiO)2]

51134-25-9

Diphenyltetramethylcyclotrisiloxane [(PhMeSiO)2(Me2SiO)] (chemno 298)

35964-76-2

o-Tolylheptamethylcyclotetrasiloxane [(o-TolylMeSiO)(Me2SiO3)] (chemno 300)

17156-72-8

Phenylhexamethylcyclotetrasiloxane [(PhHSiO)(Me2SiO)3] (chemno 302)

17964-44-2

PhMe[SiCH2CH2SiMePhO] (chemno 303)

92569-29-4

1,1-Bis(4-hydroxyphenyl)-2-ethyl-n-butane (chemno 306)

No CAS 025

1,1-Bis(4-hydroxyphenyl)-2-n-propylpentane (chemno 307)

1844-00-4

1,1-Bis(4-hydroxyphenyl)-iso-butane (chemno 309)

7615-24-9

2,2,5,5-Tetra(4-hydroxyphenyl)-n-hexane (chemno 315)

No CAS 027

2,2,6,6-Tetramethyl-4,4-bis(4-hydroxyphenyl)-n-heptan (chemno 316)

3555-19-9

2,2-Bis(4-hydroxyphenyl)-3-methyl-n-butane (chemno 319)

41709-94-8

2,2-Bis(4-hydroxyphenyl)-n-heptane (chemno 322)

6052-90-0

2,2-Bis(4-hydroxyphenyl)-n-octane (chemno 324)

4204-58-4

2,2-Bis(4-hydroxyphenyl)-n-pentane (chemno 325)

31127-54-5

2,3,4,4’-Tetrahydroxybenzophenon (chemno 329)

10196-77-7

3,3-Bis(4-hydroxyphenyl)-n-hexane (chemno 331)

3600-64-4

3,3-Bis(4-hydroxyphenyl)-n-pentane (chemno 332)

7425-79-8

4,4-Bis(4-hydroxyphenyl)-n-heptane (chemno 333)

No CAS 026

4,4-Bis(4-hydroxyphenyl)-n-octane (chemno 334)

21388-77-2

4-Hydroxyphenyl-4’-methoxyphenylmethane (chemno 336)

57547-76-9

5,5-Bis(4-hydroxyphenyl)-n-nonane (chemno 337)

59176-75-9

6,6-Bis(4-hydroxyphenyl)-n-undekane (chemno 338)

10193-50-7

Bis(3-hydroxyphenyl)methane (chemno 339)

36425-15-7

Bisphenol A-(epichlorhydrin) .. metacrylate polymer (chemno 341)

25068-38-6

Bisphenol A-(epichlorhydrin) polymer (chemno 342)

105839-18-7

C16  or  C18  polymerized  bisphenol-A,  butylglydiocylether,  epichlorhydrine  or  1AN,N’-
bis(2aminoethyl)ethane-1,2-diamin (chemno 344)

No CAS 098

cresol-bisphenol-A formaldehyde polymer (chemno 345)

66070-77-7

Dehydrated Castor oil polymere with bisphenol-=A of epichlorhydrine (chemno 346)

98824-88-5

Epichlorhydrin-bisphenol  A/F,  reactionproducts,  C12-C14  aliphatic  ...  (DER  353)  (chemno
347)

40

25085-75-0

Formaldehyde, polymer with 4,4’-(1-methylidene)bis(phenol) (chemno 349)

93572-41-9

Linseed  oil,  reaction  products  with  1-[[2-[(2-aminoethyl)amin)-3-phenoxy-2-propanol,
bisphenol A-diglycidylether, formaldehyde or pentaethylenehexamnine (chemno 350)

No CAS 028

Tetrabromobisphenol A (TBBP-A) (chemno 351)

115489-12-8

1,1-Bis(4-hydroxyphenyl)-1-(4-methoxyphenyl)ethane (chemno 352)

1571-75-1

1,1-Bis(4-hydroxyphenyl)-1-phenylethane (chemno 353)

No CAS 029

2,4-Dihydroxytriphenylmethancarbonacidlacton (chemno 354)

135505-63-4

4-Hydroxyphenyl-di-a-naphthylmethane (chemno 357)

791-92-4

4-Hydroxy-triphenylmethane (chemno 358)

115481-73-7

Bis(4-hydroxyphenyl)[(2-phenoxysulfonyl)phenyl]methane (chemno 359)

630-95-5

Diphenyl-a-naphthylcarbinol (chemno 361)

4865-83-2

1,3-Bis(4-hydroxyphenyl)pentane (chemno 362)

2549-50-0

1,3-Bis(4-hydroxyphenyl)propane (chemno 363)

85-95-0

2,4-Bis(4-hydroxyphenyl)-3-ethylhexane (chemno 364)

No CAS 030

2,4-Bis(4-hydroxyphenyl)-3-ethylpentane (chemno 365)

140131-31-3

3,5-Bis(4-hydroxyphenyl)heptane (chemno 366)

No CAS 127

2,4-6-trichlorobiphenyl (chemno 372)

No CAS 124

2,5-Dichlorobiphenyl (chemno 373)

No CAS 128

3,4’,5-trichlorobiphenyl (chemno 375)

No CAS 125

3,5-Dichlorobiphenyl (chemno 376)

67651-37-0

3-Hydroxy-2’,3’,4’,5’-tetrachlorobiphenyl (chemno 377)

100702-98-5

4,4’-Dihydroxy-2,3,5,6-tetrachlorobiphenyl (chemno 379)

56858-70-9

4,4’-Dihydroxy-2’-chlorobiphenyl (chemno 380)

13049-13-3

4,4’-Dihydroxy-3,3’,5,5’-tetrachlorobiphenyl (chemno 381)

53905-33-2

4-Hydroxy-2,2’,5’-trichlorobiphenyl (chemno 382)

67651-34-7

4-Hydroxy-2’,3’,4’,5’-tetrachlorobiphenyl (chemno 383)

14962-28-8

4-Hydroxy-2’,4’,6’-trichlorobiphenyl (chemno 384)

79881-33-7

4-Hydroxy-2’,6’-dichlorobiphenyl (chemno 386)

No CAS 040

4-Hydroxy-3’,3’,4’,5’-tetrachlorobiphenyl (chemno 388)

No CAS 126

4-hydroxy-3,5-dichlorobiphenyl (chemno 390)

No CAS 097

4-OH-2,2’,4’,5,5’-pentachlorobiphenyl (chemno 392)

54991-93-4

Clophen A30 (chemno 393)

41

8068-44-8

Clophen A50 (chemno 394)

No CAS 038

Mixture  of  2,3,4,5-tetrachlorobiphenyl  (PCB  61),  2,2’,4,5,5’-octachlorobiphenyl  (PCB  101)
and 2,2’,3,3’,4,4’,5,5’-octachlorobiphenyl (PCB 194) (chemno 395)

No CAS 039

PCB 104 (2,2’,4,6,6’-Pentachlorobiphenyl) (chemno 398)

No CAS 041

PCB 105 (2,3,3’,4,4’ -Pentachlorobiphenyl) (chemno 399)

No CAS 092

PCB 114 (2,3,4,4’,5-pentachlorobiphenyl) (chemno 401)

No CAS 111

PCB 118 (2,3’,4,4’,5-pentachlorobiphenyl) (chemno 402)

No CAS 042

PCB 122 (2,3,3’,4,5 -Pentachlorobiphenyl) (chemno 403)

No CAS 037

PCB 126 (3,3’,4,4’,5-Pentachlorobiphenyl) (chemno 404)

No CAS 110

PCB 28 (2,4,4’-trichlorobiphenyl) (chemno 414)

No CAS 036

PCB Aroclor 1016 (chemno 424)

No CAS 035

PCB hydroxy metabolites (chemno 431)

No CAS 087

PCB138 (chemno 432)

No CAS 088

PCB180 (chemno 433)

No CAS 134

Polychlorinated diphenyl ether (chemno 434)

12642-23-8

PCT Aroclor 5442 (chemno 440)

617883-33-8

Polychlorinated terphenyls PCT (mixture) (chemno 441)

553-39-9

2-Hydroxy-6-naphthylpropionacid (chemno 443)

No CAS 031

Halowax 1014 (chemno 447)

No CAS 032

Mixture  of  1,2,3,5,6,7-hexachloronaphthalene  and  1,2,3,6,7-hexachloronaphthalene  (chemno
448)

20291-73-0

1,9-Dimethylphenanthrene (chemno 450)

573-22-8

1-Oxo-1,2,3,4-tetrahydrophenanthrene (chemno 451)

58024-06-9

2,8-Dihydroxy-4b,5,6,10b,11,12-hexahydrochrysene (chemno 452)

No CAS 089

2,8-dihydroxy-5,6,11,12,13,14-hexahydrochrysene (chemno 453)

56614-97-2

3,9-Dihydroxybenz(a)anthracene (chemno 454)

7099-43-6

5,6-Cyclopento-1,2-benzanthracene (chemno 456)

No CAS 047

9,10-Dihydroxy-9,10-diethyl-9,10-dihydro-1,2,5,6-dibenzanthracene (chemno 458)

63041-53-2

9,10-Dihydroxy-9,10-di-n-butyl-9,10-dihydro-1,2,5,6-dibenzanthracene (chemno 459)

63041-56-5

9,10-Dihydroxy-9,10-di-n-propyl-9,10-dihydro-1,2,5,6-dibenzanthracene (chemno 460)

5684-12-8

Dehydrodoisynolacid = Bisdehydrodoisynolacid (chemno 463)

No CAS 048

PAHs (chemno 465)

No CAS 112

1,2,4,7,8-PeCDD (chemno 468)

42

No CAS 115

1,3,7,8-TeBCDD (chemno 469)

109333-32-6

2,8-Dibromo-3,7-dichlorodibenzodioxin (chemno 474)

131167-13-0

2-Bromo-1,3,7,8-tetrachlorodibenzodioxin (chemno 475)

No CAS 093

2-Bromo-3,7,8-trichlorodibenzodioxin (chemno 476)

97741-74-7

7-Bromo-2,3-dichlorodibenzodioxin (chemno 477)

112344-57-7

8-Methyl-2,3,7-trichlorodibenzodioxin (chemno 478)

No CAS 049

Dioxins/Furans = PCDDs/PCDFs (chemno 479)

No CAS 113

TeBCDD (chemno 480)

125652-16-6

6-Ethyl-1,3,8-trichlorodibenzofuran (chemno 490)

125652-13-3

6-i-Propyl-1,3,8-trichlorodibenzofuran (chemno 491)

118174-38-2

6-Methyl-1,3,8-trichlorodibenzofuran (chemno 492)

139883-51-5

6-Methyl-2,3,4,8-tetrachlorodibenzofuran (chemno 493)

172485-97-1

6-Methyl-2,3,8-trichlorodibenzofuran (chemno 494)

125652-14-4

6-n-Propyl-1,3,8-trichlorodibenzofuran (chemno 495)

125652-12-2

6-t-Butyl-1,3,8-trichlorodibenzofuran (chemno 496)

103124-72-7

8-Bromo-2,3,4-trichlorodibenzofuran (chemno 497)

139883-50-4

8-Methyl-1,2,4,7-tetrachlorodibenzofuran (chemno 498)

172485-96-0

8-Methyl-1,3,6-trichlorodibenzofuran (chemno 499)

172485-98-2

8-Methyl-1,3,7-trichlorodibenzofuran (chemno 500)

172486-00-9

8-Methyl-2,3,4,7-tetrachlorodibenzofuran (chemno 501)

172485-99-3

8-Methyl-2,3,7-trichlorodibenzofuran (chemno 502)

No CAS 052

Allenolic acid (chemno 539)

No CAS 056

Azadirachtin (chemno 540)

No CAS 055

Biochanin A (chemno 542)

No CAS 054

Formononetin (chemno 550)

No CAS 135

Iodine, radioactive (chemno 552)

No CAS 091

methyl tertiary butyl ether (MTBE) (chemno 554)

No CAS 109

TEPA (chemno 561)

No CAS 136

Tetrachloro benzyltoluenes (chemno 562)

43

7DEOH(cid:3)(cid:24)(cid:29)

6XEVWDQFHV(cid:3)ZKLFK(cid:3)DUH(cid:3)GHHPHG(cid:3)127(cid:3)WR(cid:3)EH(cid:3)(’V(cid:15)(cid:3)RQ(cid:3)WKH(cid:3)EDVLV(cid:3)RI

DYDLODEOH(cid:3)LQIRUPDWLRQ(cid:3)(cid:11) (cid:20)(cid:20)(cid:12)

108-95-2

Phenol (chemno 558)

55-38-9

Fenthion (chemno 109)

68515-49-1

1,2-Benzenedicarboxylic acid, di-C9-11-branched alkyl esters, C10-rich (DIDP) (chemno 275)

107-21-1

Ethylene glycol (ethane-1,2-diol) (chemno 548)

7429-90-5

Aluminum (chemno 504)

7440-43-9

Cadmium (chemno 505)

1332-40-7

Copper oxychlor (chemno 506)

7758-98-7

Copper sulfate (chemno 507)

7439-92-1

Lead (chemno 508)

7439-97-6

Mercury (chemno 509)

22967-92-6

Methylmercury (chemno 510)

44

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(cid:20)(cid:27)(cid:16)(cid:21)(cid:19)(cid:3)-XQH(cid:3)(cid:21)(cid:19)(cid:19)(cid:20)(cid:15)(cid:3)$URQVERUJ(cid:3)(cid:11)%nOVWD(cid:12)(cid:15)(cid:3)6ZHGHQ

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•  ’HYHORSPHQW(cid:3)RI(cid:3)WHVW(cid:3)PHWKRGV(cid:18)WHVWLQJ(cid:3)VWUDWHJ\

–  To review progress on test method development in the framework of OECD

–  To discuss with EU Member and Associated States an appropriate testing strategy
in the light of existing EU legislation and the current discussions on a future EU
chemicals policy

–  To 

identify  research  requirements 

to  underpin 

the  development  of 

test

methods/testing strategies at OECD

•  5HVHDUFK(cid:3)DQG(cid:3)’HYHORSPHQW

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disruption

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researchers  involved  in  national  and  Community  research  projects  as  well  as  in
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–  To define monitoring objectives, information needs, and design requirements for
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specific substances

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for appropriate environmental tools and models for estimation of exposure.

45