1999/721/EC: Commission recommendation of 12 October 1999 on the results of the risk evaluation and on the risk reduction strategies for the substances: 2-(2-butoxyethoxy)ethanol; 2-(2-methoxyethoxy)ethanol; Alkanes, C10-13, chloro; Benzene, C10-13-alkyl derivs. (notified under document number C(1999) 3232) (Text with EEA relevance)
Date: 1999-10-12
Institutions: European Commission
Subjects: chemical product, dangerous substance, ethanol, health risk, industrial hazard, technology assessment

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COMMISSION RECOMMENDATION

of 12 October 1999

on the results of the risk evaluation and on the risk reduction strategies for the substances:
2-(2-butoxyethoxy)ethanol;
2-(2-methoxyethoxy)ethanol;
Alkanes, C10-13, chloro; Benzene, C10-13-alkyl derivs.

(notified under document number C(1999) 3232)

(Text with EEA relevance)

(1999/721/EC)

THE COMMISSION OF THE EUROPEAN COMMUNITIES,

Having regard to the Treaty establishing the European Community,

Having regard to Council Regulation (EEC) No 793/93 of 23 March 1993 on the evaluation and control
of the risks of existing substances (1) and in particular Article 11(2) thereof,

(1) Whereas Article 10 of Regulation (EEC) No 793/93 establishes the procedure to be followed for the
risk evaluation of the substances on the priority lists at the level of the Member States designated as
rapporteur;

(2) Whereas Commission Regulation (EC) No 1488/94 (2) outlines the principles for the assessment of
risks to man and the environment of existing substances in accordance with Regulation (EEC) No
793/93,

(3) Whereas the Member State rapporteur after evaluating the risk of a given priority substance to man
and the environment shall suggest where appropriate a strategy for limiting this risk, including
control measures and/or surveillance programmes;

(4) Whereas Article 11 of Regulation (EEC) No 793/93 foresees that the results of the risk evaluation
and the recommended strategy for limiting risks in respect of substances on the priority lists should
be adopted at Community level in accordance with the procedure laid down in Article 15 and shall
be published by the Commission;

(5) Whereas Article 1 of Regulation (EEC) No 793/93 foresees that this Regulation shall apply without
prejudice to Community legislation on the protection of consumers and on safety and protection of
health of workers at work, in particular Council Directive 89/391 EEC;

(6) Whereas a first priority list identifying priority substances requiring attention has been adopted by
Commission Regulation (EC) No 1179/94 (3); whereas this priority list provides, among other
substances, for the evaluation of the following:

(cid:151) 2-(2-butoxyethoxy)ethanol,

(cid:151) 2-(2-methoxyethoxy)ethanol,

(1) OJ L 84, 5.4.1993, p. 1.
(2) OJ L 161, 29.6.1994, p. 3.
(3) OJ L 131, 26.5.1994, p. 3.

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(cid:151) Alkanes, C10-13, chlor,

(cid:151) Benzene, C10-13-alkyl derivs.

(7) Whereas the Member States rapporteur for the four substances have completed all

the risk
evaluation activities with regard to man and environment (1) and, where appropriate, have
suggested strategies for limiting these risks;

(8) Whereas the results of the risk evaluation of the four substances and the recommended risk
reduction strategies for three of the four substances concerned should be adopted at Community
level;

(9) Whereas in accordance with Article 11(3) of Regulation (EEC) No 793/93 the Commission will
consider the results of the risk evaluation and the recommended strategy for limiting the risks,
when proposing Community measures in the framework of Council Directive 76/769 EEC of 27
July 1976 on the approximation of the laws, regulations and administrative provisions of the
Member States relating to restrictions on the marketing and use of certain dangerous substances
and preparations (2) and in the framework of Council Directive 89/391 EEC of 12 June 1989 on
the introduction of measures to encourage improvements in the safety and health of workers at
work (3), as well as in the framework of other relevant existing Community instruments;

(10) Whereas the Scientific Committee on Toxicity, Ecotoxicity and the Environment (CSTEE) has been
consulted and has issued an opinion with respect to the risk assessment reports referred to in this
recommendation;

(11) Whereas the measures provided for in this recommendation are in accordance with the opinion of

the Committee set up pursuant to Article 15 of Regulation (EEC) No 793/93.

HEREBY FORMULATES THIS RECOMMENDATION:

1. All sectors producing, transporting, storing, formulating into a preparation or other processing, using

and disposing or recovering the following substances:

(cid:151) 2-(2-butoxyethoxy)ethanol

CAS No 112-34-5
Einecs No 203-961-6

(cid:151) 2-(2-methoxyethoxy)ethanol

CAS No 111-77-3
Einecs No 203-906-6

(cid:151) Alkanes, C10-13, chloro
CAS No 85535-84-8
Einecs No 287-476-5

(human
should take into account the results of the risk evaluation as summarised in Section I
to this recommendation. These results were
health/environment) of Parts 1, 2, 3 of Annex I
formulated in the light of the opinions delivered by the Scientific Committee on Toxicity, Ecotoxicity
and the Environment (CSTEE) (4).

2. The risk reduction strategies described in Section II (strategy for limiting the risks), Parts 1, 2, 3 of

Annex I to this recommendation should be implemented.

(1) The comprehensive risk assessment reports as forwarded to the Commission by the Member States rapporteur are
publicly available. Short summaries are also available. Both can be obtained by contacting the European Chemicals
Bureau, Institute for Health and Consumer Protection of the Joint Research Centre in Ispra, Italy.

(2) OJ L 262, 27.9.1976, p. 201.
(3) OJ L 183, 29.6.1989, p. 1.
(4) The risk evaluation reports were peer-reviewed by the CSTEE and its opinions were expressed at the sixth CSTEE
plenary meeting held in Brussels on 27 November 1998. The CSTEE opinions can be found on the Internet
(http://www.europa.eu.int/comm/dg24/health/sc/sct/outcome_en.html).

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3. All sectors producing, transporting, storing, formulating into a preparation or other processing, using

and disposing or recovering the following substance:

(cid:151) Benzene, C10-13-alkyl derivs.
CAS No 67774-74-7
Einecs No 267-051-0

should take into account the results of the risk evaluation as summarised in Section I
(Human
health/environment) of Annex II to this recommendation. These results were formulated in the light of
the opinion delivered by the Scientific Committee on Toxicity, Ecotoxicity and the Environment
(CSTEE).

Done at Brussels, 12 October 1999.

For the Commission

Margot WALLSTR(cid:214)M

Member of the Commission

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ANNEX I

PART ONE

CAS No 112-34-5

Einecs No 203-961-6

CH3-(CH2)3-O-CH2-CH2-O-CH2-CH2-OH

Einecs name:

2-(2-butoxyethoxy)ethanol

Member State rapporteur:

The Netherlands

Classification:

Xi; R 36

The risk assessment is based on current practices related to the life cycle of the substance as described in the risk
evaluation forwarded to the Commission by the Member State rapporteur.

The risk assessment, based on the available information, has determined that in the European Community the substance
is mainly used in preparations of cleaning agents (e.g. floor and metal cleaners) for industry and public domain. It is
further used as solvent in paints and coatings in the industrial and public sector. A minor utilisation of the substance
consists in the use as chemical intermediate for butyldiglycol acetate.

I. RISK ASSESSMENT

A. Human health

The conclusion of the evaluation of the risks to man for

WORKERS

is that there is a need for specific measures to limit the risks. This conclusion is reached because of:

(cid:151) concerns for anticipated local effects as a consequence of dermal and respiratory exposure arising from manual

application of products containing the substance,

(cid:151) concerns for anticipated general systemic effects as a consequence of repeated respiratory exposure arising from

manual application of products containing the substance.

The conclusion of the evaluation of the risks to man for

CONSUMERS

is that there is a need for specific measures to limit the risks. This conclusion is reached because of:

(cid:151) concerns for anticipated local effects as a consequence of respiratory exposure arising from spraying application of

products containing the substance.

The conclusion of the evaluation of the risks to man for

MAN EXPOSED VIA THE ENVIRONMENT

is that there is at present no need for further information and/or testing or for risk reduction measures beyond those
which are being applied. This conclusion is reached because:

(cid:151) the risk assessment shows that risks related to the populations mentioned above are not expected. Risk reduction

measures already being applied are considered sufficient.

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B. Environment

The conclusion of the evaluation of the risks to the environment for

AQUATIC ECOSYSTEMS, MICRO-ORGANISMS in the SEWAGE TREATMENT PLANT, ATMOSPHERE, TERRESTRIAL
ECOSYSTEM and NON-COMPARTMENT SPECIFIC EFFECTS RELEVANT to the FOOD CHAIN

is that there is at present no need for further information and/or testing or for risk reduction measures beyond those
which are being applied. This conclusion is reached because:

(cid:151) the risk assessment shows that risks related to the environment spheres mentioned above are not expected. Risk

reduction measures already being applied are considered sufficient.

II. STRATEGY FOR LIMITING RISKS

for WORKERS

The legislation for workers’ protection currently in force at Community level
adequate framework to limit the risks of the substance to the extend needed.

is generally considered to give an

Within the framework it is recommended:

(cid:151) to prescribe as a good practice in the safety data sheets adequate eye protection (goggles) and hand protection

(gloves) to all persons handling the pure substance,

(cid:151) to provide in the safety data sheets information on the risks resulting from the manual application of products

containing the substance,

(cid:151) to provide adequate training and instructions to the workers as well as information and consultation on the risks

resulting from the manual application of products containing the substance,

(cid:151) to develop at Community level occupational exposure limit values for the substance;

for CONSUMERS

It is recommended that paints containing the substance and which are intended for spray applications should not be
made available to consumers. Furthermore, paints containing the substance and which are available to consumers,
should contain a use instruction on the product to clearly indicate that they should not be sprayed.

In the first place it is recommended to pursue these objectives through a unilateral self-binding commitment made by
the producers, the importers of the substance, the trade organisations representing the companies manufacturing the
products containing the substance (the formulators). The commitment should be recognised by the public authorities.
The producers, the importers of the substance and the formulators should subsequently implement the measures and
monitor the compliance to the commitment periodically. The results achieved should be assessed at regular intervals
and appropriate additional measures should be considered if necessary.

PART TWO

CAS No 111-77-3

Einecs No 203-906-6

CH3-O-CH2-CH2-O-CH2-CH2-OH

Einecs name:

2-(2-methoxyethoxy)ethanol

Member State rapporteur:

the Netherlands

Classification:

Repr. Cat. 3; R 63

The risk assessment is based on current practices related to the life cycle of the substance as described in the risk
evaluation forwarded to the Commission by the Member State rapporteur.

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The risk assessment, based on the available information, has determined that in the European Community the substance
is mainly used as an anti-icing agent in jet fuel. Further uses are as a chemical intermediate, basic chemical (processing
solvent), in paint strippers and solvent in paints or floor polish.

I. RISK ASSESSMENT

A. Human health

The conclusion of the evaluation of the risks to man for

WORKERS

is that there is a need for specific measures to limit the risks. This conclusion is reached because of:

(cid:151) concerns for anticipated general systemic effects as a consequence of repeated dermal exposure arising from
production of the substance, formulation of products containing the substance and manual application of products
containing the substance,

(cid:151) concerns for anticipated developmental effects as a consequence of dermal exposure arising from formulation of

products containing the substance and manual application of products containing the substance.

The conclusion of the evaluation of the risks to man for

CONSUMERS

is that there is a need for specific measures to limit the risks. This conclusion is reached because of:

(cid:151) concerns for general systemic and developmental effects as a consequence of exposure arising from consumer use

of paints or paint strippers containing the substance.

The conclusion of the evaluation of the risks to man for

MAN EXPOSED VIA THE ENVIRONMENT

is that there is at present no need for further information and/or testing or for risk reduction measures beyond those
which are being applied. This conclusion is reached because:

(cid:151) the risk assessment shows that risks related to the populations mentioned above are not expected. Risk reduction

measures already being applied are considered sufficient.

B. Environment

The conclusion of the evaluation of the risks to the environment for

AQUATIC ECOSYSTEM, MICRO-ORGANISMS in the SEWAGE TREATMENT PLANT, ATMOSPHERE, TERRESTRIAL
ECOSYSTEM and NON-COMPARTMENT SPECIFIC EFFECTS RELEVANT to the FOOD CHAIN

is that there is at present no need for further information and/or testing or for risk reduction measures beyond those
which are being applied. This conclusion is reached because:

(cid:151) the risk assessment shows that risks related to the environmental spheres mentioned above are not expected. Risk

reduction measures already being applied are considered sufficient.

II. STRATEGY FOR LIMITING RISKS

for WORKERS

The legislation for workers protection currently in force at Community level is generally considered to give an adequate
framework to limit the risks of the substance to the extent needed.

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Within this framework it is recommended:

(cid:151) to provide as a good practice additional information on the risks resulting from the production of the substance,
formulation of products containing the substance and manual application of products containing the substance, for
instance in the safety data sheets,

(cid:151) to emphasise risks posed to women in the reproductive age,

(cid:151) to provide adequate training and instructions to the workers as well as information and consultation on the risks

resulting from the manual application of products containing the substance,

(cid:151) to develop at Community level occupational exposure limit values for the substance;

for CONSUMERS

It is recommended to prevent dermal exposure of consumers to paints and paint strippers containing the substance.

It is recommended to clearly state in use instructions on these products (packaging, containers) the fact that women in
the reproductive age are a vulnerable group.

Furthermore, industry should commit itself to substituting the substance in paints and paint strippers for substances
posing less risk, without shifting the risks to other human populations or environmental compartments.

In the first place it is recommended to pursue these objectives through a unilateral self-binding commitment made by
the producers, the importers of the substance, the trade organisations representing the companies manufacturing the
products containing the substance (the formulators). The commitment should be recognised by the public authorities.
The producers, the importers of the substance and the formulators should subsequently implement the measures and
monitor the compliance to the commitment periodically. The results achieved should be assessed at regular intervals
and appropriate additional measures should be considered if necessary.

CAS No 85535-84-8

Einecs No 287-476-5

PART THREE

CxH(2x ﬂ y + 2)Cly where x = 10 ﬂ 13 AND y = 1 ﬂ 13

Einecs name:

Alkanes, C10 ﬂ 13, chloro

Member State rapporteur:

United Kingdom

Classification:

Carc. Cat. 3; R 40
N; R 50-53

The risk assessment is based on current practices related to the life cycle of the substance as described in the risk
evaluation forwarded to the Commission by the Member State rapporteur.

The risk assessment, based on the available information, has determined that in the European Community the substance
is mainly used as an additive in metal working fluids. Other uses are as a flame retardant in rubber formulations and as
an additive for paints and other coating systems. Minor uses reported are as a fatting and softening agent in the leather
industry, an impregnation agent in the textile industry and as an additive for sealing compounds. It was not possible to
obtain information on the use of the total volume of the substances produced or imported into the European
Community, therefore, some uses may exist which are not covered by this risk assessment.

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I. RISK ASSESSMENT

A. Human health

The conclusion of the evaluation of the risks to man for

WORKERS, CONSUMERS and MAN EXPOSED VIA THE ENVIRONMENT

is that there is at present no need for further information and/or testing or for risk reduction measures beyond those
which are being applied. This conclusion is reached because:

(cid:151) the risk assessment shows that risks related to the population mentioned above are not expected. The main route
of potential worker exposure during production and use is via dermal exposure. Inhalation is also a potential route
of exposure during use of metal working fluids and hot-melt adhesives containing the substance. Risk reduction
measures already being applied in the framework of the workplace or other relevant Community legislation in
force are considered sufficient,

(cid:151) Consumer exposure, which may occur by contact with leather goods treated with the substance and from

non-professional use of metal working fluids, was considered not to be of concern.

B. Environment

The conclusion of the evaluation of the risks to the environment for

AQUATIC (sediment) and TERRESTRIAL ECOSYSTEM

is that there is a need for further information and/or testing. This conclusion is reached because:

(cid:151) there is a need for better information to adequately characterise the risk to sediment compartment arising from
production of the substance and its use in rubber, to the soil and sediment compartments arising from the
formulation and use of metal working fluids and leather finishing products, and to the soil and sediment
compartments at regional level.

The information requirements are:

(cid:151) experimental determination of the Koc,

(cid:151) monitoring data in soil and sediment near sources of release,

(cid:151) toxicity testing on soil and sediment dwelling organisms if the abovementioned information does not remove the

concern for the abovementioned compartments.

The conclusion of the evaluation of the risks to the environment for

MICRO-ORGANISMS in the SEWAGE TREATMENT PLANT and ATMOSPHERE

is that there is at present no need for further information and/or testing or for risk reduction measures beyond those
which are being applied. This conclusion is reached because:

(cid:151) the risk assessment shows that risks related to the environmental spheres mentioned above are not expected. Risk

reduction measures already being applied are considered sufficient.

The conclusion of the evaluation of the risks to the environment for

AQUATIC (excluding sediment) ECOSYSTEM and NON-COMPARTMENT SPECIFIC EFFECTS RELEVANT TO THE
FOOD CHAIN

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is that there is a need for specific measures to limit the risks. This conclusion is reached because of:

(cid:151) concerns for effects on the local aquatic environmental spheres mentioned above as a consequence of exposure
arising from formulation and use of metal working fluids containing the substance and leather finishing products
containing the substance,

(cid:151) concerns for non-compartmental specific effects relevant to the food chain arising from the formulation and use of
leather finishing products containing the substance and from use of metal working fluids containing the substance.

II. STRATEGY FOR LIMITING RISKS

for the ENVIRONMENT

Marketing and use restrictions should be considered at Community level for the substance to protect the environment
from the use and formulation of products, in particular for use in metal working and leather finishing. Further work is
necessary to establish those uses for which derogations can be justified.

The measures identified to protect the environment will also reduce human exposure.

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CAS No 67774-74-7

Einecs No 267-051-0

ANNEX II

CH3-(CH2)m-CH(C6H5)-(CH2)n-CH3 where m + n = 7 : 10

Einecs name:

benzene, C10 ﬂ 13-alkyl derivs.

Member State rapporteur:

Italy

Classification:

not yet classified

The risk assessment is based on current practices related to the life cycle of the substance as described in the risk
evaluation forwarded to the Commission by the Member State rapporteur.

The risk assessment, based on the available information, has determined that in the European Community the substance
is mainly used as an intermediate in the chemical industry for the production of linear alkyl benzenesulphonates. Minor
uses reported are as a solvent or binder for asphalt, paints,
It was not possible to obtain
information on the use of the total volume of the substances produced or imported into the European Community,
therefore, some uses may exist which are not covered by this risk assessment.

inks and varnishes.

I. RISK ASSESSMENT

A. Human Health

The conclusion of the evaluation of the risks to man for

WORKERS, CONSUMERS and MAN EXPOSED VIA THE ENVIRONMENT

is that there is at present no need for further information and/or testing or for risk reduction measures beyond those
which are being applied. This conclusion is reached because:

(cid:151) the risk assessment shows that risks related to the populations mentioned above are not expected. Risk reduction

measures already being applied are considered sufficient.

B. Environment

The conclusion of the evaluation of the risks to the environment for

AQUATIC ECOSYSTEM, MICRO-ORGANISMS in the SEWAGE TREATMENT PLANT, ATMOSPHERE, TERRESTRIAL
ECOSYSTEM and NON-COMPARTMENT SPECIFIC EFFECTS RELEVANT TO THE FOOD CHAIN

is that there is at present no need for further information and/or testing or for risk reduction measures beyond those
which are being applied.

This conclusion is reached because:

(cid:151) the risk assessment shows that risks related to the environmental spheres mentioned above are not expected. Risk

reduction measures already being applied are considered sufficient.

None

II. STRATEGY FOR LIMITING RISKS