Commission Regulation (EC) No 508/1999 of 4 March 1999 amending Annexes I to IV to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin
Date: 1999-03-04
Institutions: European Commission
Subjects: animal product, food inspection, veterinary drug, waste

L 60/16

EN

Official Journal of the European Communities

9. 3. 1999

COMMISSION REGULATION (EC) No 508/1999

of 4 March 1999

amending Annexes I to IV to Council Regulation (EEC) No 2377/90 laying down a
Community procedure for the establishment of maximum residue limits of
veterinary medicinal products in foodstuffs of animal origin

THE COMMISSION OF THE EUROPEAN COMMUNITIES,

Having regard to the Treaty establishing the European
Community,

Having regard to Council Regulation (EEC) No 2377/90
of 26 June 1990 laying down a Community procedure for
the establishment of maximum residue limits of veter-
inary medicinal products in foodstuffs of animal origin (1),
as last amended by Commission Regulation (EC) No
2728/98 (2), and in particular Articles 6, 7 and 8 thereof,

Whereas, since the adoption of Regulation (EEC) No
2377/90, the Annexes have been amended a number of
times; whereas, since the texts are numerous, complex
and dispersed among various Official Journals, they are
difficult to use and thus lack the clarity which should be
an essential feature of all legislation; whereas, certain of
those Annexes should therefore be consolidated; whereas
on the same occasion the name or chemical description

of some compounds should be rectified or made more
precise and certain material errors should be corrected;

Whereas the measures provided for in this Regulation are
in accordance with the opinion of
the Standing
Committee on Veterinary Medicinal Products,

HAS ADOPTED THIS REGULATION:

Article 1

Annexes I to IV to Regulation (EEC) No 2377/90 are
hereby replaced by the texts set out in the Annex to this
Regulation.

Article 2

This Regulation shall enter into force on the 60th day
following that of its publication in the Official Journal of
the European Communities.

This Regulation shall be binding in its entirety and directly applicable in all Member
States.

Done at Brussels, 4 March 1999.

For the Commission

Martin BANGEMANN

Member of the Commission

(1) OJ L 224, 18. 8. 1990, p. 1.
(2) OJ L 343, 18. 12. 1998, p. 8.

LIST OF PHARMACOLOGICALLY ACTIVE SUBSTANCES FOR WHICH MAXIMUM RESIDUE LIMITS HAVE BEEN FIXED

ANNEX I

Anti-infectious agents
Chemotheurapeutics

1.
1.1.
1.1.1. Sulfonamides

Pharmacologically active
substance(s)

All substances belonging
to the sulfonamide group

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Parent drug

All food-producing species

Bovine, ovine, caprine

100 lg/kg Muscle
100 lg/kg
100 lg/kg
100 lg/kg Kidney
100 lg/kg Milk

Fat
Liver

The combined total residues of all substances
within the sulfonamide group should not
exceed 100 lg/kg

1.1.2. Diamino pyrimidine derivatives

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Baquiloprim

Baquiloprim

Bovine

Porcine

Trimethoprim

Trimethoprim

Bovine

Porcine

Equidae

Fat
Liver

10 lg/kg
300 lg/kg
150 lg/kg Kidney
30 lg/kg Milk
40 lg/kg
50 lg/kg
50 lg/kg Kidney

Skin and fat
Liver

Fat
Liver

50 lg/kg Muscle
50 lg/kg
50 lg/kg
50 lg/kg Kidney
50 lg/kg Milk
50 lg/kg Muscle
50 lg/kg
50 lg/kg
50 lg/kg Kidney
100 lg/kg Muscle
100 lg/kg
100 lg/kg
100 lg/kg Kidney

Fat
Liver

Skin and fat
Liver

9

.

3

.

1
9
9
9

E
N

O

f
f
i
c
i
a
l

J
o
u
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n
a
l

o
f

t
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e
E
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a
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C
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m
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L
6
0
/
1
7

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Poultry

Not for use in animals from which eggs
are produced for human consumption

Fin fish

50 lg/kg Muscle
50 lg/kg
50 lg/kg
50 lg/kg Kidney
50 lg/kg Muscle and

Skin and fat
Liver

skin in natural
proportions

1.2.

Antibiotics

1.2.1. Penicillins

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Amoxicyllin

Amoxicyllin

All food-producing species

Ampicillin

Ampicillin

All food-producing species

Benzylpenicillin

Benzylpenicillin

All food-producing species

Cloxacillin

Cloxacillin

All food-producing species

50 lg/kg Muscle
50 lg/kg
50 lg/kg
50 lg/kg Kidney
4 lg/kg Milk

Fat
Liver

50 lg/kg Muscle
50 lg/kg
50 lg/kg
50 lg/kg Kidney
4 lg/kg Milk

Fat
Liver

50 lg/kg Muscle
50 lg/kg
50 lg/kg
50 lg/kg Kidney
4 lg/kg Milk

Fat
Liver

300 lg/kg Muscle
300 lg/kg
300 lg/kg
300 lg/kg Kidney
30 lg/kg Milk

Fat
Liver

L
6
0
/
1
8

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
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o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

9

.

3

.

1
9
9
9

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Dicloxacillin

Dicloxacillin

All food-producing species

Oxacillin

Oxacillin

All food-producing species

Penethamate

Benzylpenicillin

Bovine

300 lg/kg Muscle
300 lg/kg
300 lg/kg
300 lg/kg Kidney
30 lg/kg Milk

Fat
Liver

300 lg/kg Muscle
300 lg/kg
300 lg/kg
300 lg/kg Kidney
30 lg/kg Milk

Fat
Liver

50 lg/kg Muscle
50 lg/kg
50 lg/kg
50 lg/kg Kidney
4 lg/kg Milk

Fat
Liver

1.2.2. Cephalosporins

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Cefazolin

Cefazolin

Bovine, ovine, caprine

50 lg/kg Milk

Cefquinome

Cefquinome

Bovine

50 lg/kg Muscle
50 lg/kg
100 lg/kg
200 lg/kg Kidney
20 lg/kg Milk

Fat
Liver

9

.

3

.

1
9
9
9

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
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o
p
e
a
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C
o
m
m
u
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t
i
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s

L
6
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/
1
9

1.2.3. Quinolones

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Danofloxacin

Danofloxacin

Bovine

Not for use in animals from which milk is
produced for human consumption

Chicken

Not for use in animals from which eggs
are produced for human consumption

Fat
Liver

200 lg/kg Muscle
100 lg/kg
400 lg/kg
400 lg/kg Kidney
200 lg/kg Muscle
100 lg/kg
400 lg/kg
400 lg/kg Kidney

Skin and fat
Liver

Difloxacin

Difloxacin

Chicken, turkey

300 lg/kg Muscle
400 lg/kg
1 900 lg/kg

Skin and fat
Liver

600 lg/kg Kidney

Enrofloxacin

Sum of enrofloxacin and
ciprofloxacin

Bovine

Rabbits

Porcine

Poultry

Not for use in animals from which eggs
are produced for human consumption

Fat
Liver

Fat
Liver

100 lg/kg Muscle
100 lg/kg
300 lg/kg
200 lg/kg Kidney
100 lg/kg Milk
100 lg/kg Muscle
100 lg/kg
200 lg/kg
300 lg/kg Kidney
100 lg/kg Muscle
100 lg/kg
200 lg/kg
300 lg/kg Kidney
100 lg/kg Muscle
100 lg/kg
200 lg/kg
300 lg/kg Kidney

Skin and fat
Liver

Skin and fat
Liver

L
6
0
/
2
0

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
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C
o
m
m
u
n
i
t
i
e
s

9

.

3

.

1
9
9
9

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Sarafloxacin

Sarafloxacin

Chicken

Salmonidae

10 lg/kg
100 lg/kg
30 lg/kg Muscle and

Skin and fat
Liver

skin in natural
proportions

1.2.4. Macrolides

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Spiramycin

Sum of spiramycin and
neospiramycin

Bovine

Chicken

Tilmicosin

Tilmicosin

Bovine, ovine, porcine

Ovine
Chicken

Tylosin

Tylosin A

Bovine

Fat
Liver

200 lg/kg Muscle
300 lg/kg
300 lg/kg
300 lg/kg Kidney
200 lg/kg Milk
200 lg/kg Muscle
300 lg/kg
400 lg/kg

Skin and fat
Liver

Fat
Liver

50 lg/kg Muscle
50 lg/kg
1 000 lg/kg
1 000 lg/kg Kidney
50 lg/kg Milk
75 lg/kg Muscle
75 lg/kg
1 000 lg/kg

Skin and fat
Liver

250 lg/kg Kidney

100 lg/kg Muscle
100 lg/kg
100 lg/kg
100 lg/kg Kidney
50 lg/kg Milk

Fat
Liver

Not for use in animals from which eggs are
produced for human consumption

9

.

3

.

1
9
9
9

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
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o
p
e
a
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C
o
m
m
u
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i
t
i
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s

L
6
0
/
2
1

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Porcine

Poultry

Not for use in hens producing eggs for
human consumption

Skin and fat
Liver

100 lg/kg Muscle
100 lg/kg
100 lg/kg
100 lg/kg Kidney
100 lg/kg Muscle
100 lg/kg
100 lg/kg
100 lg/kg Kidney

Skin and fat
Liver

1.2.5. Florfenicol and related compounds

Pharmacologically active
substance(s)

Florfenicol

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Sum of
florfenicol and
its metabolites measured
as florfenicol-amine

Bovine

200 lg/kg Muscle

3 000 lg/kg

Liver

300 lg/kg Kidney

Thiamphenicol

Thiamphenicol

Bovine

Chicken

Not for use in animals from which eggs
are produced for human consumption

Fat
Liver

50 lg/kg Muscle
50 lg/kg
50 lg/kg
50 lg/kg Kidney
50 lg/kg Milk
50 lg/kg Muscle
50 lg/kg
50 lg/kg
50 lg/kg Kidney

Skin and fat
Liver

1.2.6. Tetracyclines

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Chlortetracycline

Sum of parent drug and All food-producing species
its 4- epimer

Liver

100 lg/kg Muscle
300 lg/kg
600 lg/kg Kidney
100 lg/kg Milk
Eggs
200 lg/kg

L
6
0
/
2
2

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

9

.

3

.

1
9
9
9

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Doxycycline

Doxycycline

Bovine

Not for use in animals from which milk is
produced for human consumption

Porcine

Poultry

Not for use in animals from which eggs
are produced for human consumption

Oxytetracycline

Sum of parent drug and All food-producing species
its 4-epimer

Tetracycline

Sum of parent drug and All food-producing species
its 4-epimer

Skin and fat
Liver

Skin and fat
Liver

Liver

100 lg/kg Muscle
300 lg/kg
600 lg/kg Kidney
100 lg/kg Muscle
300 lg/kg
300 lg/kg
600 lg/kg Kidney
100 lg/kg Muscle
300 lg/kg
300 lg/kg
600 lg/kg Kidney

Liver

100 lg/kg Muscle
300 lg/kg
600 lg/kg Kidney
100 lg/kg Milk
Eggs
200 lg/kg

Liver

100 lg/kg Muscle
300 lg/kg
600 lg/kg Kidney
100 lg/kg Milk
Eggs
200 lg/kg

1.2.7. Naphtalene-ringed ansamycin

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Rifaximin

Rifaximin

Bovine

60 lg/kg Milk

1.2.8. Pleuromutilines

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Valnemulin

Valnemulin

Porcine

50 lg/kg Muscle
500 lg/kg
100 lg/kg Kidney

Liver

9

.

3

.

1
9
9
9

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
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o
p
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a
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C
o
m
m
u
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t
i
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s

L
6
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/
2
3

Antiparasitic agents
Agents acting against endoparasites

2.
2.1.
2.1.1. Salicylanilides

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Closantel

Closantel

Bovine

Ovine

Fat
Liver

1 000 lg/kg Muscle
3 000 lg/kg
1 000 lg/kg
3 000 lg/kg Kidney
1 500 lg/kg Muscle
2 000 lg/kg
1 500 lg/kg
5 000 lg/kg Kidney

Fat
Liver

2.1.2. Tatra-hydro-imidazoles (imidazolthiazoles)

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Levamisole

Levamisole

Bovine, ovine, porcine, poultry

10 lg/kg Muscle
10 lg/kg
100 lg/kg
10 lg/kg Kidney

Fat
Liver

2.1.3. Benzimidazoles and pro-benzimidazoles

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Pharmacologically active
substance(s)

Albendazole

Bovine, ovine

albendazole
Sum of
sulphoxide,
albendazole
sulphone, and albenda-
zole 2-amino sulphone,
expressed as albendazole

Febantel

Sum of extractable resi-
be
dues which may
oxidised to oxfendazole

Bovine, ovine
Bovine, ovine, porcine, equidae

100 lg/kg Muscle
100 lg/kg
1 000 lg/kg

Fat
Liver

500 lg/kg Kidney
100 lg/kg Milk

10 lg/kg Milk
50 lg/kg Muscle
50 lg/kg
500 lg/kg
50 lg/kg Kidney

Fat
Liver

L
6
0
/
2
4

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

9

.

3

.

1
9
9
9

Pharmacologically active
substance(s)

Fenbendazole

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Sum of extractable resi-
dues which may
be
oxidised to oxfendazole
sulphone

Bovine, ovine
Bovine, ovine, porcine, equide

10 lg/kg Milk
50 lg/kg Muscle
50 lg/kg
500 lg/kg
50 lg/kg Kidney

Fat
Liver

Flubendazole

Oxfendazole

Sum of flubendazole and
(2-amino 1H-benzimida-
zol-5-yl)
(4fluorophenyl)
methanone

Porcine, chicken, game birds

Flubendazole

Chicken

Sum of extractable resi-
dues which may
be
oxidised to oxfendazole
sulphone

Bovine, ovine
Bovine, ovine, porcine, equidae

Oxibendazole

Oxibendazole

Porcine

Thiabendazole

Sum of
thiabendazole
and 5-hydroxythiabenda-
zole

Bovine

Triclabendazole

Sum of extractable resi-
dues
be
that may
oxidised to ketotricla-
bendazole

Bovine, ovine

50 lg/kg Muscle
50 lg/kg
400 lg/kg
300 lg/kg Kidney
400 lg/kg

Eggs

Skin and fat
Liver

10 lg/kg Milk
50 lg/kg Muscle
50 lg/kg
500 lg/kg
50 lg/kg Kidney

Fat
Liver

100 lg/kg Muscle
500 lg/kg
200 lg/kg
100 lg/kg Kidney

Skin and fat
Liver

100 lg/kg Muscle
100 lg/kg
100 lg/kg
100 lg/kg Kidney
100 lg/kg Milk

Fat
Liver

100 lg/kg Muscle

100 lg/kg
100 lg/kg Kidney

Liver

Not for use in animals from which milk is
produced for human consumption

9

.

3

.

1
9
9
9

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
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s

L
6
0
/
2
5

2.2.

Agents acting against ectoparasites

2.2.1. Organophosphates

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Diazinon

Diazinon

Bovine, ovine, caprine
Bovine, porcine, ovine, caprine

20 lg/kg Milk
20 lg/kg Muscle
700 lg/kg
20 lg/kg
20 lg/kg Kidney

Fat
Liver

2.2.2. Formamidines

Pharmacologically active
substance(s)

Amitraz

2.2.3. Pyrethroids

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Sum of amitraz and all
metabolites
containing
the
2,4-DMA moiety,
expressed as amitraz

Bovine

Ovine

Porcine

Fat
Liver

200 lg/kg
200 lg/kg
200 lg/kg Kidney
10 lg/kg Milk
400 lg/kg
100 lg/kg
200 lg/kg Kidney
10 lg/kg Milk
400 lg/kg
200 lg/kg
200 lg/kg Kidney

Fat
Liver

Skin and fat
Liver

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Flumethrin

Flumethrin
trans-Z isomers)

(sum of

Bovine

10 lg/kg Muscle
150 lg/kg
20 lg/kg
10 lg/kg Kidney
30 lg/kg Milk

Fat
Liver

L
6
0
/
2
6

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

9

.

3

.

1
9
9
9

2.3.

Agents acting against endo- and ectoparasites

2.3.1. Avermectins

Phramacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Abamectin

Avermectin B1a

Bovine

10 lg/kg
20 lg/kg

Fat
Liver

Not for use in bovine from which milk is
produced for human consumption

for use in ovine from which milk is

Not
produced for human consumption

Doramectin

Doramectin

Bovine

Porcine, ovine

Eprinomectin

Eprinomectin B1a

Bovine

Ivermectin

23-Dihydro-aver-

22,
mectin B1a

Bovine

Porcine, ovine, equidae

Deer, including reindeer

Fat
Liver

10 lg/kg Muscle
150 lg/kg
100 lg/kg
30 lg/kg Kidney
20 lg/kg Muscle
100 lg/kg
50 lg/kg
30 lg/kg Kidney

Fat
Liver

30 lg/kg Muscle
30 lg/kg
600 lg/kg
100 lg/kg Kidney
30 lg/kg Milk

Fat
Liver

Fat
Liver
Fat
Liver

40 lg/kg
100 lg/kg
20 lg/kg
15 lg/kg
20 lg/kg Muscle
100 lg/kg
50 lg/kg
20 lg/kg Kidney

Fat
Liver

Moxidectin

Moxidectin

Bovine, ovine

50 lg/kg Muscle
500 lg/kg
100 lg/kg
50 lg/kg Kidney

Fat
Liver

9

.

3

.

1
9
9
9

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
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s

L
6
0
/
2
7

2.4.

Agents acting against protozoa

2.4.1. Triazinetrione derivative

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Toltrazuril

Toltrazuril sulfone

Chicken

Turkey

3.

Agents acting on the nervous system

3.1.

Agents acting on the central nervous system

3.1.1. Butyrophenone tranquillisers

Not for use in animals from which eggs are
produced for human consumption

Skin and fat
Liver

100 lg/kg Muscle
200 lg/kg
600 lg/kg
400 lg/kg Kidney
100 lg/kg Muscle
200 lg/kg
600 lg/kg
400 lg/kg Kidney

Skin and fat
Liver

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Azaperone

Sum of azaperone and
azaperol

Porcine

100 lg/kg Muscle
100 lg/kg
100 lg/kg
100 lg/kg Kidney

Skin and fat
Liver

3.2.

Agents acting on the autonomic nervous system

3.2.1. Anti-adrenergics

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Carazolol

Carazolol

Porcine

5 lg/kg Muscle
5 lg/kg
25 lg/kg
25 lg/kg Kidney

Skin and fat
Liver

L
6
0
/
2
8

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

9

.

3

.

1
9
9
9

Anti-inflammatory agents

4.
4.1. Nonsteroidal anti-inflammatory agents
4.1.1. Arylpropionic acid derivative

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Vedaprofen

Vedaprofen

Equidae

50 lg/kg Muscle
20 lg/kg
100 lg/kg

Fat
Liver

1 000 lg/kg Kidney

4.1.2. Fenamate group derivatives

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Tolfenamic acid

Tolfenamic acid

Bovine

Porcine

Liver

50 lg/kg Muscle
400 lg/kg
100 lg/kg Kidney
50 lg/kg Milk
50 lg/kg Muscle
400 lg/kg
100 lg/kg Kidney

Liver

5.
5.1.

Corticoides
Glucocorticoides

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Dexamethasone

Dexamethasone

Bovine
Bovine, porcine, equidae

0,3 lg/kg Milk
0,75 lg/kg Muscle

2 lg/kg

Liver

0,75 lg/kg Kidney

9

.

3

.

1
9
9
9

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

L
6
0
/
2
9

LIST OF SUBSTANCES NOT SUBJECT TO MAXIMUM RESIDUE LIMITS

ANNEX II

1. Inorganic chemicals

Pharmacologically active substance(s)

Animal species

Other provisions

Aluminium distearate

All food-producing species

Aluminium hydroxide acetate

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

For oral use only

All food-producing species

For oral use only

All food-producing species

For oral use only

All food-producing species

For oral use only

All food-producing species

All mammalian food-producing species

For topical use only

All food-producing species

Aluminium phosphate

Aluminium tristearate

Ammonium chloride

Bismuth subcarbonate

Bismuth subgallate

Bismuth subnitrate

Bismuth subsalicylate

Boric acid and borates

Bromide, sodium salt

Calcium acetate
Calcium benzoate
Calcium carbonate
Calcium chloride
Calcium gluconate
Calcium hydroxide
Calcium hypophosphite
Calcium malate
Calcium oxide
Calcium phosphate
Calcium polyphosphates
Calcium propionate
Calcium silicate
Calcium stearate
Calcium sulphate

L
6
0
/
3
0

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

9

.

3

.

1
9
9
9

Pharmacologically active substance(s)

Animal species

Other provisions

Calcium glucoheptonate

Calcium glucono glucoheptonate

Calcium gluconolactate

Calcium glutamate

Cobalt carbonate

Cobalt dichloride

Cobalt gluconate

Cobalt oxide

Cobalt sulphate

Cobalt trioxide

Copper chloride

Copper gluconate

Copper heptanoate

Copper methionate

Copper oxide

Copper sulphate

Dicopper oxide

Hydrochloric acid

Hydrogen peroxide

Iodine and iodine inorganic compounds including:
— Sodium and potassium-iodide
— Sodium and potassium-iodate
— Iodophors including polyvinylpyrrolidone-iodine

Iron dichloride

Iron sulphate

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

For use as excipient

All food-producing species

All food-producing species

All food-producing species

All food-producing species

9

.

3

.

1
9
9
9

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

L
6
0
/
3
1

Pharmacologically active substance(s)

Animal species

Other provisions

Magnesium
Magnesium sulphate
Magnesium hydroxide
Magnesium stearate
Magnesium glutamate
Magnesium orotate
Magnesium aluminium silicate
Magnesium oxide
Magnesium carbonate
Magnesium phosphate
Magnesium glycerophosphate
Magnesium aspartate
Magnesium citrate
Magnesium acetate
Magnesium trisilicate

Nickel gluconate

Nickel sulphate

Potassium DL-aspartate

Potassium glucuronate

Potassium glycerophosphate

Potassium nitrate

Potassium selenate

Sodium chlorite

Sodium dichloroisocyanurate

Sodium hypophosphite

Sodium selenate

Sodium selenite

Sulphur

Zinc acetate
Zinc chloride
Zinc gluconate
Zinc oleate
Zinc stearate

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

Bovine

Bovine, ovine, caprine

All food-producing species

All food-producing species

All food-producing species

Bovine, porcine, ovine, caprine, equidae

All food-producing species

For topical use only

For topical use only

L
6
0
/
3
2

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

9

.

3

.

1
9
9
9

2. Organic compounds

Pharmacologically active substance(s)

Animal species

Other provisions

17b-Oestradiol

2-Aminoethanol

All mammalian food-producing species

For therapeutic and zootechnical uses only

All food-producing species

2-Aminoethyl dihydrogenphosphate

All food-producing species

2-Pyrrolidone

8-Hydroxyquinoline

Acetyl cysteine

Alfacalcidol

Alfaprostol

Bacitracin

All food-producing species

At parenteral doses up to 40 mg/kg bw

All mammalian food-producing species

For topical use in newborn animals only

All food-producing species

Bovine

For parturient cows only

Rabbits
Bovine, porcine, equidae

Bovine

For intramammary use in lactating cows only and for all tissues
except milk

Benzalkonium chloride

All food-producing species

For use as an excipient at concentrations up to 0,05 % only

Benzocaine

Benzylalcohol

Betaine

Bronopol

Brotizolam

Buserelin

All food-producing species

For use as local anaesthetic only

All food-producing species

For use as excipient

All food-producing species

Salmonidae

Bovine

All food-producing species

For use only on farmed fertilised eggs

For therapeutic uses only

Butorphanol tartrate

Equidae

For intravenous administration only

Butyl 4-hydroxybenzoate

All food-producing species

9

.

3

.

1
9
9
9

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

L
6
0
/
3
3

Pharmacologically active substance(s)

Animal species

Other provisions

Butylscopolaminium bromide

Caffeine

Carbetocin

Cefazolin

Cetostearyl alcohol

Cetrimide

Chlorhexidine

Chlorocresol

Clazuril

Cloprostenol

All food-producing species

All food-producing species

All mammalian food-producing species

Bovine
Ovine, caprine

All food-producing species

All food-producing species

For intramammary use, except if the udder may be used as food for
human consumption

All food-producing species

For topical use only

All food-producing species

Pigeon

Bovine, porcine, equidae

Coco alkyl dimethyl betaines

All food-producing species

For use as excipient

Corticotropin

All food-producing species

D-Phe 6 -luteinising-hormone releasing hormone

All food-producing species

Dembrexine

Denaverine hydrochloride

Detomidine

Diclazuril

Diethyl phtalate

Equidae

Bovine

Bovine, equidae

Ovine

All food-producing species

For therapeutic uses only

For oral use in lambs only

Diethylene glycol monoethyl ether

Bovine, porcine

Dimanganese trioxide

Dimethyl phtalate

Dinoprost

All food-producing species

For oral use only

All food-producing species

All mammalian food-producing species

Dinoprost tromethamine

All mammalian food-producing species

L
6
0
/
3
4

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

9

.

3

.

1
9
9
9

Pharmacologically active substance(s)

Animal species

Other provisions

Diprophylline

Etamiphylline camsylate

Ethanol

Ethyl lactate

Etiproston tromethamine

Fertirelin acetate

Flumethrin

Folic acid

Glycerol formal

All food-producing species

All food-producing species

All food-producing species

For use as excipient

All food-producing species

Bovine, porcine

Bovine

Bees (honey)

All food-producing species

All food-producing species

Gonadotrophin releasing hormone

All food-producing species

Heptaminol

Hesperidin

Hesperidin methyl chalcone

Hexetidine

All food-producing species

Equidae

Equidae

Equidae

Human chorion gonadotrophin

All food-producing species

Human menopausal urinary gonadotrophin

Bovine

For topical use only

Hydrocortisone

Iodine organic compounds
— Iodoform

Isobutane

Isoflurane

Isoxsuprine

Ketamine

All food-producing species

For topical use only

All food-producing species

All food-producing species

Equidae

Bovine, equidae

All food-producing species

For use as anaesthetic only

For therapeutic use only in accordance with Council Directive
96/22/EEC (OJ L 125, 23.5.1996, p. 3)

Ketanserin tartrate

Equidae

9

.

3

.

1
9
9
9

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

L
6
0
/
3
5

Pharmacologically active substance(s)

Animal species

Other provisions

Ketoprofen

Bovine, porcine, equidae

L-tartaric acid and its mono- and di-basic salt of sodium, potassium
and calcium

All food-producing species

For use as excipient

Lactic acid

Lecirelin

Lobeline

Luprostiol

Malic acid

Manganese carbonate

Manganese chloride

Manganese gluconate

Manganese glycerophosphate

Manganese oxide

Manganese pidolate

Manganese ribonucleate

Manganese sulphate

Mecillinam

Medroxyprogesterone acetate

Melatonin

Menadione

Menbutone

Menthol

All food-producing species

Bovine, equidae, rabbits

All food-producing species

All mammalian species

All food-producing species

For use as excipient

For oral use only

For oral use only

For oral use only

For oral use only

For oral use only

For oral use only

For oral use only

For oral use only

For intrauterine use only

For intravaginal use for zootechnical purposes only

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

Bovine

Ovine

Ovine, caprine

All food-producing species

Bovine, ovine, caprine, porcine, equidae

All food-producing species

Methyl nicotinate

Bovine, equidae

For topical use only

Mineral hydrocarbons, low to high viscosity including microcristal-
line waxes, approximately C10-C60; aliphatic, branched aliphatic
and alicyclic compounds

All food-producing species

Excludes aromatic and unsaturated compounds

L
6
0
/
3
6

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

9

.

3

.

1
9
9
9

Pharmacologically active substance(s)

Animal species

Other provisions

N-butane

N-butanol

Natamycin

Neostigmine

Nicoboxil

Nonivamide

Oleyloleate

Oxytocin

Pancreatin

Papain

Papaverine

Peracetic acid

Phenol

Phloroglucinol

Phytomenadione

Policresulen

All food-producing species

All food-producing species

For use as excipient

Bovine, equidae

For topical use only

All food-producing species

Equidae

Equidae

For topical use only

For topical use only

All food-producing species

For topical use only

All mammalian food-producing species

All mammalian food-producing species

For topical use only

All food-producing species

Bovine

Newborn calves only

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

For topical use only

Polyethylene glycol 15 hydroxystearate

All food-producing species

For use as excipient

Polyethylene glycol 7 glyceryl cocoate

All food-producing species

For topical use only

Polyethylene glycol stearates with 8-40 oxyethylene units

All food-producing species

For use as excipient

Polysulphated glycosaminoglycan

Equidae

9

.

3

.

1
9
9
9

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

L
6
0
/
3
7

Pharmacologically active substance(s)

Animal species

Other provisions

Praziquantel

Ovine
Equidae

For use in non-lactating sheep only

Pregnant mare serum gonadotrophin

All food-producing species

Prethcamide (crotethamide and cropropamide)

All mammalian food-producing species

Procaine

Propane

Propylene glycol

Quatresin

R-Cloprostenol

Rifaximin

Romifidine

All food-producing species

All food-producing species

All food-producing species

All food-producing species

For use as preservative only at concentrations of up to 0,5 %

Bovine, porcine, equidae

All mammalian food-producing species

For topical use only

Bovine

Equidae

For intramammary use, except if the udder may be used as food for
human consumption

For therapeutic uses only

Sodium 2-methyl-2-phenoxy-propanoate

Bovine, porcine, caprine, equidae

Sodium benzyl 4-hydroxybenzoate

All food-producing species

Sodium butyl 4-hydroxybenzoate

All food-producing species

Sodium cetostearyl sulphate

All food-producing species

For topical use only

Somatosalm

Tanninum

Tau fluvalinate

Terpin hydrate

Tetracaine

Salmon

All food-producing species

Bovine, porcine, ovine, caprine

All food-producing species

For use as anaesthetic only

L
6
0
/
3
8

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

9

.

3

.

1
9
9
9

Pharmacologically active substance(s)

Animal species

Other provisions

Theobromine

Theophylline

Thiomersal

Thymol

Timerfonate

Trimethylphloroglucinol

Vitamin D

Wool alcohols

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

For use only as preservatives in multidose vaccines at a concentra-
tion not exceeding 0,02 %

For use only as preservatives in multidose vaccines at a concentra-
tion not exceeding 0,02 %

All food-producing species

For topical use only

3. Substances generally recognised as safe

Pharmacologically active substance(s)

Animal species

Other provisions

Absinthium extract

Acetylmethionine

Aluminium hydroxide

Aluminium monostearate

Ammonium sulfate

Benzoyl benzoate

Benzyl p-hydroxybenzoate

Calcium borogluconate

Calcium citrate

Camphor

Cardamon extract

Diethyl sebacate

Dimethicone

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

External use only

All food-producing species

All food-producing species

All food-producing species

9

.

3

.

1
9
9
9

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

L
6
0
/
3
9

Pharmacologically active substance(s)

Animal species

Other provisions

Dimethyl acetamide

Dimethyl sulphoxide

Epinephrine

Ethyl oleate

All food-producing species

All food-producing species

All food-producing species

All food-producing species

Ethylenediaminetetraacetic acid and salts

All food-producing species

Eucalyptol

All food-producing species

Follicle stimulating hormone (natural FSH from all species and
their synthetic analogues)

All food-producing species

Formaldehyde

Formic acid

Glutaraldehyde

Guaiacol

Heparin and its salts

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

Human chorionic gonadotropin (natural HCG and its synthetic
analogues)

All food-producing species

Iron ammonium citrate

Iron dextran

Iron glucoheptonate

Isopropanol

Lanolin

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

Luteinising hormone (natural LH from all species and their
synthetic analogues)

All food-producing species

Magnesium chloride

Magnesium gluconate

All food-producing species

All food-producing species

L
6
0
/
4
0

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

9

.

3

.

1
9
9
9

Pharmacologically active substance(s)

Animal species

Other provisions

(molecular weight

ranging from 200 to

All food-producing species

Magnesium hypophosphite

Mannitol

Methylbenzoate

Monothioglycerol

Montanide

Myglyol

Orgotein

Poloxalene

Poloxamer

Polyethylene glycols
10 000)

Polysorbate 80

Serotonin

Sodium chloride

Sodium cromoglycate

Sodium dioctylsulphosuccinate

Sodium formaldehydesulphoxylate

Sodium lauryl sulphate

Sodium pyrosulphite

Sodium stearate

Sodium thiosulphate

Tragacanth

Urea

Zinc oxide

Zinc sulphate

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

9

.

3

.

1
9
9
9

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

L
6
0
/
4
1

4. Substances used in homeopathic veterinary medicinal products

Pharmacologically active substance(s)

Animal species

Other provisions

All substances used in homeopathic veterinary medicinal products
provided that their concentration in the product does not exceed
one part per ten thousand

All food-producing species

5. Substances used as food additives in foodstuffs for human consumption

Pharmacologically active substance(s)

Animal species

Other provisions

Substances with an E number

All food-producing species

Only substances approved as additives in foodstuffs for human
consumption, with the exception of preservatives listed in part C of
Annex III to European Parliament and Council Directive 95/2/EC
(OJ L 61, 18.3.1995, p. 1).

6. Substances of vegetable origin

Pharmacologically active substance(s)

Animal species

Other provisions

Angelicae radix aetheroleum

Anisi aetheroleum

Balsamum peruvianum

Carvi aetheroleum

Caryophylli aetheroleum

All food-producing species

All food-producing species

All food-producing species

For topical use only

All food-producing species

All food-producing species

Chrysanthemi cinerariifolii flos

All food-producing species

For topical use only

Cinnamomi cassiae aetheroleum

All food-producing species

Cinnamomi ceylanici aetheroleum

All food-producing species

Citri aetheroleum

Citronellae aetheroleum

Coriandri aetheroleum

Echinacea purpurea

Eucalypti aetheroleum

Foeniculi aetheroleum

All food-producing species

All food-producing species

All food-producing species

All food-producing species

For topical use only

All food-producing species

All food-producing species

L
6
0
/
4
2

E
N

O

f
f
i
c
i
a
l

J
o
u
r
n
a
l

o
f

t
h
e
E
u
r
o
p
e
a
n
C
o
m
m
u
n
i
t
i
e
s

9

.

3

.

1
9
9
9

Pharmacologically active substance(s)

Animal species

Other provisions

Hamamelis virginiana

Hyperici oleum

Lespedeza capitata

Lini oleum

Majoranae herba

Matricariae flos

For topical use only

For topical use only

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

Medicago sativa extractum

All food-producing species

For topical use only

Melissae folium

All food-producing species

Menthae piperitae aetheroleum

All food-producing species

Millefolii herba

Myristicae aetheroleum

All food-producing species

All food-producing species

For use in newborn animals only

Oxidation products of Terebinthinae oleum

Bovine, porcine, ovine, caprine

Pyrethrum extract

Quercus cortex

Quillaia saponins

Ricini oleum

Rosmarini aetheroleum

Rosmarini folium

Salviae folium

Sambuci flos

Sinapis nigrae semen

All food-producing species

For topical use only

All food-producing species

All food-producing species

All food-producing species

For use as excipient

All food-producing species

All food-producing species

All food-producing species

All food-producing species

All food-producing species

Terebinthinae aetheroleum rectificatum

All food-producing species

For topical use only

9

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9
9

E
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Pharmacologically active substance(s)

Animal species

Other provisions

Terebinthinae laricina

Thymi aetheroleum

Tiliae flos

Urticae herba

All food-producing species

For topical use only

All food-producing species

All food-producing species

All food-producing species

L
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4

E
N

O

f
f
i
c
i
a
l

J
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n
a
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o
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t
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9

LIST OF PHARMACOLOGICALLY ACTIVE SUBSTANCES USED IN VETERINARY MEDICINAL PRODUCTS FOR WHICH PROVISIONAL MAXIMUM RESIDUE
LIMITS HAVE BEEN FIXED

ANNEX III

Anti-infectious agents
Chemotheurapeutics

1.
1.1.
1.1.2. Benzenesulphonamides

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Clorsulon

Clorsulon

Bovine

50 lg/kg Muscle
150 lg/kg
400 lg/kg Kidney

Liver

Provisional MRLs expire on 1 January 2000

Antibiotics

1.2.
1.2.1. Beta-lactamase inhibitors

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Clavulanic acid

Clavulanic acid

Bovine, ovine
Bovine, ovine, porcine

Provisional MRLs expire on 1 July 1999

200 lg/kg Milk
200 lg/kg Muscle
200 lg/kg
200 lg/kg
200 lg/kg Kidney

Fat
Liver

Marker residue

Animal species

MRLs

Target tissues

Other provisions

1.2.2. Macrolides

Pharmacologically active
substance(s)

Erythromycin

MRLs apply to all micro-
biological active residues
expressed
erythro-
as
mycin equivalent

Bovine, ovine
Bovine, ovine, porcine, poultry

Josamycin

Josamycin

Poultry

Chicken

Provisional MRLs expire on 1 June 2000

Provisional MRLs expire on 1 July 2000

40 lg/kg Milk
400 lg/kg Muscle
400 lg/kg
400 lg/kg
400 lg/kg Kidney
200 lg/kg

Fat
Liver

Eggs

200 lg/kg Muscle
200 lg/kg
200 lg/kg
400 lg/kg Kidney
200 lg/kg

Fat
Liver

Eggs

9

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9
9

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1.2.5. Aminoglycosides

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Aminosidine

Aminosidine

Bovine, porcine, rabbits, chicken

500 lg/kg Muscle

1 500 lg/kg
1 500 lg/kg Kidney

Liver

Provisional MRLs expire on 1 July 2000

Apramycin

Apramycin

Bovine

For use in non-lactating cattle only

Porcine

Dihydrostreptomycin

Dihydrostreptomycin

Bovine, ovine
Bovine, ovine, porcine, poultry

Gentamicin

Gentamicin

Bovine
Bovine, porcine

Neomycin (including
framycetin)

Neomycin

Bovine, ovine, caprine
Bovine, ovine, caprine, porcine, chicken,
turkey, duck

Chicken

Fat
Liver

1 000 lg/kg Muscle
1 000 lg/kg
10 000 lg/kg
20 000 lg/kg Kidney
1 000 lg/kg Muscle
1 000 lg/kg
1 000 lg/kg
5 000 lg/kg Kidney

Skin and fat
Liver

200 lg/kg Milk
500 lg/kg Muscle
500 lg/kg
500 lg/kg

Fat
Liver

1 000 lg/kg Kidney

100 lg/kg Milk
100 lg/kg Muscle
100 lg/kg
200 lg/kg

Fat
Liver

1 000 lg/kg Kidney

500 lg/kg Milk
500 lg/kg Muscle
500 lg/kg
500 lg/kg

Fat
Liver

5 000 lg/kg Kidney

500 lg/kg

Eggs

Provisional MRLs expire on 1 July 1999

Provisional MRLs expire on 1 June 2000

Provisional MRLs expire on 1 June 2000

Provisional MRLs expire on 1 June 2000

L
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E
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O

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J
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Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Spectinomycin

Spectinomycin

Bovine
Bovine, porcine, poultry

Streptomycin

Streptomycin

Bovine, ovine
Bovine, ovine, porcine, poultry

Provisional MRLs expire on 1 July 2000

Provisional MRLs expire on 1 June 2000

200 lg/kg Milk
300 lg/kg Muscle
500 lg/kg
2 000 lg/kg
5 000 lg/kg Kidney

Fat
Liver

200 lg/kg Milk
500 lg/kg Muscle
500 lg/kg
500 lg/kg

Fat
Liver

1 000 lg/kg Kidney

1.2.6. Quinolones

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Decoquinate

Decoquinate

Bovine, ovine

Enrofloxacin

Sum of enrofloxacin and Ovine
ciprofloxacin

Flumequine

Flumequine

Bovine, ovine, porcine, chicken

Marbofloxacin

Marbofloxacin

Bovine

Salmonidae

Provisional MRLs expire on 1 July 2000

Provisional MRLs expire on 1 July 1999

Provisional MRLs expire on 1 January 2000

Provisional MRLs expire on 1 July 2000

500 lg/kg Muscle
500 lg/kg
500 lg/kg
500 lg/kg Kidney

Fat
Liver

100 lg/kg Muscle
100 lg/kg
300 lg/kg
200 lg/kg Kidney

Fat
Liver

50 lg/kg Muscle
50 lg/kg

Fat or skin and
fat
Liver

100 lg/kg
300 lg/kg Kidney
150 lg/kg Muscle and

skin

150 lg/kg Muscle
50 lg/kg
150 lg/kg
150 lg/kg Kidney
75 lg/kg Milk

Fat
Liver

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Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Porcine

150 lg/kg Muscle
50 lg/kg
150 lg/kg
150 lg/kg Kidney

Skin and fat
Liver

1.2.9. Polymyxins

Phamarcologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Colistin

Colistin

Bovine, ovine
Bovine, ovine, porcine, chicken, rabbits

Chicken

50 lg/kg Milk
150 lg/kg Muscle
150 lg/kg
150 lg/kg
200 lg/kg Kidney
300 lg/kg

Fat
Liver

Eggs

Provisional MRLs expire on 1 July 2000

1.2.10. Penicillins

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Penethamate

Benzylpenicillin

Ovine

Porcine

Provisional MRLs expire on 1 January 2000

Fat
Liver

50 lg/kg Muscle
50 lg/kg
50 lg/kg
50 lg/kg Kidney
4 lg/kg Milk
50 lg/kg Muscle
50 lg/kg
50 lg/kg
50 lg/kg Kidney

Fat
Liver

1.2.11. Florfenicol and related compounds

Pharmacologically active
substance(s)

Florfenicol

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Sum of
florfenicol and
its metabolites measured
as florfenicol-amine

Fish

1 000 lg/kg Muscle

and
skin in natural
proportions

Provisional MRLs expire on 1 July 2001

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8

E
N

O

f
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2.

Antiparasitic agents

2.1.

Agents acting against endoparasites

2.1.2. Benzimidazoles and pro-benzimidazoles

Pharmacologically active
substance(s)

Albendazole sulphoxide

Netobimin

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Bovine, ovine
Bovine, ovine, pheasant

Bovine, ovine, caprine

albendazole,
Sum of
albendazole sulphoxide,
albendazole
sulphone,
and albendazole 2-amino
sulphone, expressed as
albendazole

Sum of netobimin and
albendazole and meta-
bolites
albendazole
measured as 2-amino-
benzimidazole sulphone

of

Provisional MRLs expire on 1 January 2000

Provisional MRLs expire on 31 July 1999

100 lg/kg Milk
100 lg/kg Muscle
100 lg/kg
1 000 lg/kg

Fat
Liver

500 lg/kg Kidney

100 lg/kg Muscle
100 lg/kg
1 000 lg/kg

Fat
Liver

500 lg/kg Kidney
100 lg/kg Milk

2.2.

Agents acting against ectoparasites

2.2.1. Formamidines

Pharmacologically active
substance(s)

Amitraz

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Sum of amitraz and all
metabolites
containing
the
2,4-DMA moeity,
expressed as amitraz

Bees

200 lg/kg Honey

Provisional MRLs expire on 1 July 1999

2.2.2.

Iminophenyl thiazolidine derivative

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Cymiazole

Cymiazole

Bees

1 000 lg/kg Honey

Provisional MRLs expire on 1 July 1999

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3

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9
9

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N

O

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2.2.3. Pyretrin and pyrethroids

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Cyfluthrin

Cyfluthrin

Bovine

Provisional MRLs expire on 1 January 2001

10 lg/kg Muscle
50 lg/kg
10 lg/kg
10 lg/kg Kidney
20 lg/kg Milk

Fat
Liver

provisions

in Council
Further
Directive
to be
94/29/EC are
observed (OJ L 189, 23.7.1994, p.
67)

2.2.4. Organophosphates

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Azamethiphos

Azamethiphos

Salmonidae

100 lg/kg Muscle and skin in

Provisional MRLs expire on 1 June 1999

natural proportions

2.2.5. Acyl urea derivates

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Teflubenzuron

Teflubenzuron

Salmonidae

500 lg/kg Muscle and skin in

Provisional MRLs expire on 1 July 1999

natural proportions

2.3.

Agents acting against endo- and ectoparasites

2.3.1. Avermectins

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Moxidectin

Moxidectin

Equidae

50 lg/kg Muscle
500 lg/kg
100 lg/kg
50 lg/kg Kidney

Fat
Liver

Provisional MRLs expire on 1 January 2000

L
6
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/
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0

E
N

O

f
f
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Agents acting on the nervous system
Agents acting on the autonomic nervous system

3.
3.2.
3.2.1. b2 sympathomimetic agents

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Clenbuterol hydrochloride Clenbuterol

Bovine

Indication:
parturient cows

solely

for

tocolysis

in

Equidae

Indications: tocolysis and the treatment
of respiratory ailments

Anti-inflammatory agents

5.
5.1. Nonsteroidal anti-inflammatory agents
5.1.1. Arylpropionic acid derivative

Liver

0,1 lg/kg Muscle
0,5 lg/kg
0,5 lg/kg Kidney
0,05 lg/kg Milk
0,1 lg/kg Muscle
0,5 lg/kg
0,5 lg/kg Kidney

Liver

Provisional MRLs expire on 1 July 2000

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Carprofen

Carprofen

Bovine

Equidae

Provisional MRLs expire on 1 January 2000

Fat
Liver

500 lg/kg Muscle
500 lg/kg
1 000 lg/kg
1 000 lg/kg Kidney
50 lg/kg Muscle
100 lg/kg
1 000 lg/kg
1 000 lg/kg Kidney

Fat
Liver

5.1.2. Enolic acid derivates

Pharmacologically active
substance(s)

Marker residue

Animal species

MRLs

Target tissues

Other provisions

Meloxicam

Meloxicam

Bovine

25 lg/kg Muscle
60 lg/kg
35 lg/kg Kidney

Liver

Provisional MRLs expire on 1 January 2000

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L 60/52

EN

Official Journal of the European Communities

9. 3. 1999

LIST OF PHARMACOLOGICALLY ACTIVE SUBSTANCES FOR WHICH NO MAXIMUM
LEVELS CAN BE FIXED

ANNEX IV

Pharmacologically active substance(s)

Aristolochia spp. and preparations thereof

Chloramphenicol

Chloroform

Chlorpromazine

Colchicine

Dapsone

Dimetridazole

Metronidazole

Nitrofurans (including furazolidone)

Ronidazole