Karen McCluskey (née Simonds) is a fictional character from the ABC television series Desperate Housewives. The role was played by Kathryn Joosten, who won the Primetime Emmy Award twice for Outstanding Guest Actress in a Comedy Series in 2005 and 2008. In the series finale, Karen succumbs to cancer. This was agreed upon between Marc Cherry and Kathryn, as she was battling cancer in real life, as well. Kathryn Joosten died 20 days after the series finale aired.