Isabella Toscano is a fictional character from the NBC soap opera Days of Our Lives. The character first appeared on a recurring basis on October 16, 1989, and was portrayed by actress Staci Greason. Greason was put on contract in December 1989. Greason left the show in October 1992, after Isabella died from pancreatic cancer. Greason reappeared later on as Isabella's ghost in 1995, 2000, 2002, 2003, and most recently in November 2010.