Cleo McQueen is a fictional character from the British soap opera Hollyoaks, played by Nadine Rose Mulkerrin. Cleo is a member of the show's established McQueen family and was introduced as the younger sister of Porsche (Twinnie-Lee Moore) and Celine McQueen (Sarah George), who arrived in late 2014. Actress Jennifer Metcalfe, who plays Mercedes McQueen, suggested that more McQueens should be introduced, as she knew the show was losing two members of the family. Mulkerrin had previously auditioned for the role of Phoebe Jackson, however this role was later given to Mandip Gill. Upon learning she had been cast as Cleo, she gave up her job as a waitress and relocated to Liverpool, where the show is filmed. She made her first appearance during the episode broadcast on 26 January 2015. Mulkerrin took maternity leave from the show in 2019, departing in the episode broadcast on 4 November 2019. She returned on 18 November 2020. Cleo is portrayed as being studious, sensible and witty. She leaves her boarding school to be with her family in Hollyoaks village. Shortly after, she is given her first love interest in Harry Thompson (Parry Glasspool), who struggles with his sexuality while dating her. Cleo is central to a long-running sexual abuse storyline, in which she is manipulated and abused by her stepfather Pete Buchanan (Kai Owen). The cast and crew worked with child protection charity NSPCC on the storyline, while Mulkerrin met with abuse survivors during her research. During the storyline Cleo is also involved in a car crash stunt, and takes the blame for killing Rachel Hardy (Jennifer Brooke) to protect her friend Holly Cunningham (Amanda Clapham). She later develops feelings for Rachel's fiancé Nathan Nightingale (Jared Garfield). Cleo's second issue-led storyline saw her taking heroin, following Nathan and Celine's deaths. Producers later paired the character with trainee priest Joel Dexter (Rory Douglas-Speed). The relationship has faced several obstacles, including a motorbike crash, Joel's recommitment to the Church, a kidnapping, and pregnancy. Cleo's third issue-led storyline saw her develop bulimia nervosa in December 2017. For her portrayal of Cleo, Mulkerrin won the Best Newcomer accolade at the 2015 Digital Spy Reader Awards. In 2017, she earned a nomination for Best Female Dramatic Performance at The British Soap Awards. She has also been longlisted for Best Actress at the Inside Soap Awards twice. Television critics praised Mulkerrin's performance during the abuse storyline. Others have enjoyed Cleo's relationship with Joel, and one stated she was the best member of the McQueen family.