Doctors is a British medical soap opera which began broadcasting on BBC One on 26 March 2000. Set in the fictional West Midlands town of Letherbridge, the soap follows the lives of the staff and patients of the Mill Health Centre, a fictional NHS doctor's surgery, as well as its sister surgery located at a nearby university campus. The following is a list of characters that first appeared in Doctors in 2021, by order of first appearance. All characters are introduced by the programme's executive producer, Mike Hobson. Luca McIntyre (Ross McLaren) made his debut in February as a nurse at the Mill. In March, PPG chairwoman (Ruthie Henshall) began appearing. (Carley Stenson) then joined in April. In September, Angela Wynter joined the cast as , the mother of Bear Sylvester (Dex Lee). Kevwe Emefe made her debut as , a patient of Ruhma Carter's (Bharti Patel), in December. Additionally, multiple appear throughout the year.