 "The Hands of Blue" (Jeff Ricketts and Dennis Cockrum): Two anonymous men wearing suits and blue gloves who pursue River, apparently to return her to the institute from which she escaped, as shown in "The Train Job", "Ariel", and the Serenity: Those Left Behind comic. They kill anyone, including Alliance personnel, who had contact with her, using a mysterious hand-held device that causes fatal hemorrhaging in anyone at whom it is aimed. River, during anxiety attacks or psychological meltdowns, has repeated the phrase "Two by two / hands of blue" in a way that resembles poetic meter. This suggests that River has had close experience (s) with them.
