 Another component of Rosetta, RosettaDock, was used in conjunction with experimental methods to model interactions between three proteins — lethal factor (LF), edema factor (EF) and protective antigen (PA) — that make up anthrax toxin. The computational model accurately predicted docking between LF and PA, helping to establish which domains of the respective proteins are involved in the LF – PA complex. This insight was eventually used in research resulting in improved anthrax vaccines.
