 Bani Zeid is situated in the central highlands of the West Bank, off the southwestern cliffs of the mountainous spine that runs from the Hebron Hills to Jenin. It has an average elevation of 510 meters (1,670 ft) above sea level. The northern part of the town (Deir Ghassaneh) is built on a hilltop with an elevation of roughly 450 meters above sea level. It overlooks the Wadi al-Saredah stream 1 kilometer (0.62 mi) to the north. Bani Zeid is located 17.5 kilometers (10.9 mi) north of Ramallah and less than 45 kilometers (28 mi) northwest of Jerusalem. Nearby localities include Kafr ad-Dik and Bruqin to the north, Qarawat Bani Zeid to the northeast, Kafr Ein to the east, Nabi Salih to the southeast, Deir Nidham and the Israeli settlement of Halamish to the south, Aboud to the southwest, al-Lubban al-Gharbi and the settlement of Beit Aryeh to the west and the settlement of Peduel to the northwest.
