 Almost all of Route 22 is a two-lane rural road that only passes through small villages and hamlets. The exceptions are its southern end in the heavily populated Bronx and lower Westchester County, and a section that runs through the city of Plattsburgh near the northern end. The rural landscape that the road passes through varies from horse country and views of the picturesque reservoirs of the New York City watershed in the northern suburbs of the city, to dairy farms further upstate in the hilly Taconic and Berkshire mountains, to the undeveloped, heavily forested Adirondack Park along the shores of Lake Champlain. An 86-mile (138 km) section from Fort Ann to Keeseville is part of the All-American Road known as the Lakes to Locks Passage.
