 Until her husband's exile, she sponsored the work of Mariotto Albertinelli, sending his paintings to her extended family throughout Italy. In 1504, Alfonsina inherited a castle near Tivoli from her mother. In 1514, her son-in-law Filippo wrote a description of her collection of ancient statues, noting they were among the best in Rome. From 1515 to 1519, she was involved with her son Lorenzo in several major construction projects, continuing construction of a villa at Poggio a Caiano, work on a lake house at Fucecchio, and rebuilding gardens in Florence. During that period, she also independently managed the construction of the Medici-Lante Palace in Rome. She employed the architect Nanni di Baccio Bigio to work on each of these projects.
