 On March 31, 2015, Billboard premiered a remix of the song by Dutch DJ Don Diablo, who changed the ballad into an EDM track. Another set of remixes were released later as a Remix EP. Two of the remixes were released on Madonna's Tidal streaming account, including one by DJ RedTop as well as Armand Van Helden, Offer Nissim and Roger Sanchez. According to Idolator, "RedTop completely deconstructs' Ghosttown 'and turns it into something you might hear in a post-apocalyptic piano bar. It's sad and depressing yet defiantly groovy." Another remix, by Paul Andrews, gave emphasis on Madonna's vocals while adding piano and orchestra in the production. Andrews explained that the music video of "Ghosttown" was how he had imagined it, "two people in a dark place with destruction all around them, but they have each other". Hence he wanted the verse to represent the reality of the situation and the chorus would represent their view of the world because of their love. The non-dance remix was approved by Madonna and was another exclusive release to her Tidal account.
