 While attending the University of California, Los Angeles, Mitchell played for the UCLA Bruins football team from 1997 to 2000. He sat out the 1997 season by taking a redshirt and subsequently lengthening his college football eligibility. In his first game, a 49 – 31 win over Texas on September 12, 1998, Mitchell threw a 34-yard touchdown pass to Brian Poli-Dixon and had four catches for 108 yards and one touchdown pass (79 yards) from quarterback Cade McNown. He had one rushing attempt for 30 yards on a reverse, 78 yards on three kickoff returns, and 17 yards on three punt returns. He was named the Pacific-10 Conference Offensive Player of the Week for his efforts in the game. On September 19, Mitchell had surgery on his left femur after suffering a fracture at the end of a kickoff return in the first quarter of a 42 – 24 win over Houston the same day. Mitchell was expected to miss the rest of the season. However, after a "remarkable" recovery, according to a member of the UCLA medical staff, Mitchell was able to play for eleven snaps in the Rose Bowl on January 1, 1999. He threw a 61-yard touchdown pass to Durell Price on a flea flicker play in the first quarter of the loss to Wisconsin.
