 MD 410 was originally built along mostly new alignment between Bethesda and Silver Spring in the late 1920s. The highway was extended east to Hyattsville in the mid-1930s. While the Montgomery County portion has not changed much in the ensuing decades, MD 410 has been realigned and extended multiple times within Prince George's County. These changes include an extension along existing roads further into Hyattsville in the mid-1940s, a realignment within Hyattsville in the mid-1950s, an extension through Riverdale in the late 1960s, and the final extension to Landover Hills in the early 1990s.
