 MD 410 begins at a pair of junctions with MD 355 (Wisconsin Avenue) and MD 187 (Old Georgetown Road) on either side of Bethesda Station on the Washington Metro's Red Line in downtown Bethesda. Westbound MD 410 ends at the intersection of two-way MD 355 and the southern terminus of MD 187, which begins one-way northbound along Old Georgetown Road. Traffic from the southbound direction of MD 187 follows Woodmont Avenue and Montgomery Lane to the start of eastbound MD 410 at the intersection of MD 355 and Montgomery Avenue. MD 410 heads east as a one-way pair — East – West Highway westbound and Montgomery Avenue eastbound — to the eastern edge of downtown Bethesda, where the two directions converge east of Bethesda-Chevy Chase High School. From that intersection, which includes a U-turn ramp from Montgomery Avenue to westbound East – West Highway, the state highway continues east as four-lane undivided East – West Highway and crosses over the Capital Crescent Trail.
