 After the intersection with the latter, the route becomes a four-lane undivided road, entering Woodbury and immediately crossing a Conrail Shared Assets Operations railroad line. The road crosses another railroad line before coming to an intersection with CR 551. Here, Route 45 forms a concurrency with CR 551 and heads north-northeast on Broad Street through the downtown of Woodbury, where it intersects CR 663. Route 45 and CR 551 cross the Woodbury Creek out of the downtown area and intersect CR 644 near Inspira Medical Center Woodbury. From here, the route continues past a mix of residences and businesses as a two-lane undivided road. CR 551 splits from Route 45 by heading east on Park Avenue then north on Broadway.
