 Upon intersecting Lindenhurst Road, the route enters Lower Makefield Township and becomes Newtown Yardley Road. It passes through farmland before heading north of an office park and reaching an interchange with I-95. Following this interchange, PA 332 becomes a two-lane undivided road and enters residential areas. The route turns northeast onto Yardley Langhorne Road and crosses into Yardley, where it is known as Afton Avenue. The road heads into the downtown area and crosses the Delaware Canal. PA 332 comes to its eastern terminus at an intersection with PA 32, which runs along the Delaware River.
