 Despite this preferred theory of immuno-dysregulation held by most researchers, aphthous stomatitis behaves dissimilarly to autoimmune diseases in many regards. There is no association between aphthous stomatitis and other autoimmune diseases, which often accompany each other; common autoantibodies are not detected, the condition tends to resolve spontaneously with advancing age rather than worsen, and usually serum immunoglobulins are at normal levels.
