 Principe di Carignano saw action during the Battle of Lissa in 1866 during the Third Italian War of Independence. There, she led the Italian line, the flagship of Admiral Giovanni Vacca; the leading squadron of the Italian fleet became separated from the rest of the fleet and was not heavily engaged. Her career was limited after the war, owing to the emergence of more modern ironclads and a severe reduction in the Italian naval budget following their defeat at Lissa. The ship was stricken from the naval register in 1875 and broken up for scrap to free up funds needed for new ironclads under construction.
