 Brown was injured early in the Marshall game, and replaced by true freshman quarterback Eugene "Geno" Smith. Brown suffered a mild concussion from a helmet-to-helmet hit from two defensive backs, but returned for the next game against Connecticut. Brown completed 19 of 32 passes for 205 yards and one interception in the loss to South Florida, which snapped West Virginia's four-game winning streak. He threw one touchdown pass against Louisville, but the Mountaineers offense struggled to a 17 – 9 win. Offensive coordinator Jeff Mullen attributed a drop-off in Brown's performance from earlier in the season to a string of minor injuries. Brown scored touchdowns on a three-yard pass and an eight-yard run in a losing 24 – 21 effort against fifth-ranked Cincinnati. Late in the game against ninth-ranked Pittsburgh, Brown led a 42-yard drive to set up the game-winning field goal. In the regular season finale, Brown ran for a first down on a naked bootleg to clinch a 24 – 21 victory over Rutgers. West Virginia earned an invitation to the 2010 Gator Bowl, where it faced Florida State, but Brown was replaced by Smith after suffering an ankle injury in the first half.
