 French writer Prosper Mérimée first proposed the subject of Cleopatra and Caesar in a letter sent to Gérôme in December 1860. La Païva, a wealthy French courtesan, later commissioned the painting from Gérôme, intending it for display in the Hôtel de la Païva, her mansion on the Champs-Élysées. According to American art critic Earl Shinn, the work was originally painted on silk and was designed as a "transparency to be lowered or raised midway of a long saloon" in La Païva's mansion, "which it was desirable to divide occasionally into two".
