 In addition to the above, Missamma also dealt with issues such as unemployment and Freedom of Worship. Rama Rao's character M. T. Rao is often pronounced as "Empty" Rao, which Santhisri of Prajasakti found a reflection of the humiliations faced by unemployed graduates. Prasad's struggles in the early part of his career influenced the statements of unemployment and the state of being a learned "misfit". Pillai noted that Chakrapani's "poignant dialogues" concerning the unemployment of the educated young people undermined his unilateral projection as a mainstream writer. He also pointed out that in the scenes where Mary faces situations challenging her faith as a devout catholic, Chakrapani and Prasad "underscore their imperative to highlight the differences" and "make a plea for peaceful co-existence".
