 On the Billboard charts, The Drug in Me Is You charted at number two on the Top Hard Rock Albums chart, number three on the Top Alternative Albums and Top Rock Albums charts, number four on the Top Independent Albums chart, and number 12 on the Top Digital Albums chart, for a total of six appearances on the US Billboard charts, including the Billboard 200. Internationally, the album charted in the United Kingdom, peaking at number 125 on the national chart, as well as number four and number 17 on the UK Top 40 Rock Albums and Top Indie Albums charts, respectively. The album also peaked at number 21 on the Australian National Charts, and number 60 on the national Canadian Albums Chart.
