 Originally, Saginaw Road in the Flint area was a part of the Saginaw Trail, a Native American foot path in the area. When the state signed its highway system in 1919, Saginaw Road was part of M-10. Later it was used as a section of US 10 in 1926. By 1930, the main highway was moved eastward to follow Dort Highway, and the route through the city was designated M-10. It was renumbered to Bus. US 10 in 1941. Later, in 1962, US 10 was moved again to follow the recently completed I-75 freeway; the former route of US 10 was redesignated M-54 and its business loop was renumbered to match.
