 At the beginning of 1806, Agamemnon was with Vice-Admiral Duckworth's squadron in the West Indies, pursuing a French fleet carrying troops to Santo Domingo. On 6 February 1806, the two squadrons clashed in the Battle of San Domingo; Agamemnon assisted Duckworth's flagship Superb in driving the French Vice-Admiral Leissègues' flagship Impérial onto the shore where she was wrecked. In October, Agamemnon escorted a convoy on her return to Britain.
