 "Reaction" was written by Randy Jandt and directed by Jennifer Coyle. It originally aired on the Kids WB! block for The CW on May 3, 2008, at 10: 00 a.m. Eastern / Pacific time, with a parental guidance rating of TV-Y7-FV. The episode's title, "Reaction," expands the series theme "The Education of Peter Parker" chosen by developer Greg Weisman. Episodes in the third season one arc all shared a naming scheme based on chemistry.
