 After the bridge over the railroad line, DE 1 leaves the Delaware Beaches area and heads into a mix of farm fields and residential and commercial development, traveling to the northeast of Red Mill Pond. The road continues through more agricultural areas with some residential subdivisions and woods. The route crosses over the Broadkill River and passes to the southwest of a golf course before it comes to a junction with DE 16, which heads west to Milton and east to Broadkill Beach. Following this, DE 1 continues through farmland and woodland to the southwest of the Prime Hook National Wildlife Refuge, reaching an intersection with the northern terminus of DE 5. Immediately after this intersection, the road travels to the east of Waples Pond and runs north-northwest through more agricultural areas. The route curves northwest as it bypasses the community of Argos Corner to the southwest. Past here, DE 1 crosses Cedar Creek and passes near a couple residential subdivisions before intersecting DE 30 Alt. A short distance later, the road reaches an interchange with the northern terminus of DE 30. After this interchange, the route comes to a northbound exit and southbound entrance with DE 1 Bus., which heads northwest into Milford. At this point, DE 1 curves north and becomes the Milford Bypass, which heads around the eastern part of the city. The route passes between residential development to the west and farmland to the east before turning northwest into wooded areas and coming to a diamond interchange with DE 36.
