 In 1952, after the Constitution of the Commonwealth of Puerto Rico was promulgated, the Nationalist Party began a series of revolutionary actions, including the Jayuya Uprising. As part of this initiative, Pedro Albizu Campos ordered her to organize attacks in the United States, focusing on locations that were "the most strategic to the enemy". She became the leader of a group of nationalists, who attacked the United States House of Representatives in 1954. She was incarcerated as a result. Lebrón remained imprisoned 25 years, when President Carter issued pardons to the group involved. After their release in 1981, the nationalists returned to Puerto Rico, where independence movements received them with a celebration. During the following years she continued her involvement in pro-independence activities, including the Navy-Vieques protests. Her life would be subsequently detailed in books and a documentary. On August 1, 2010, Lebrón died from complications of a cardiorespiratory infection.
