 In 1726, at the age of 19, Hopkins married Sarah Scott, the daughter of Sylvanus Scott and Joanna Jenckes, and a great great granddaughter of early Providence settler Richard Scott whose wife was Katharine Marbury, the youngest sister of the famed Puritan dissident minister Anne Hutchinson. Richard Scott was said to be the first Quaker in Providence. Hopkins and Sarah had seven children, five of whom lived to maturity. Sarah died on September 9, 1753 at the age of 46, and following her death, Hopkins married Anne Smith, the daughter of Benjamin Smith, and the widow of an unrelated Benjamin Smith. Hopkins and Anne did not have children together. Hopkins' younger brother, Esek Hopkins, became the first commander in chief of the Continental Navy, and another brother, William, became a celebrated merchant.
