 MD 68's name changes to Lappans Road south of Williamsport. MD 63 (Spielman Road) splits south from MD 68 at the same intersection as Governor Lane Boulevard, which serves an industrial park. MD 68 crosses over the Winchester and Western Railroad and curves to the east, then resumes heading southeast after intersecting the eastern end of Kendle Road. The state highway heads southeast through farmland and intersects MD 632 (Downsville Pike). The road intersects Norfolk Southern Railway's Hagerstown District at-grade and crosses St. James Run in the hamlet of St. James. MD 68 intersects MD 65 (Sharpsburg Pike) in the hamlet of Lappans, where the highway passes St. Mark's Episcopal Church. The state highway passes through the hamlet of Brethedsville and passes Devils Backbone County Park as the highway follows Antietam Creek for a short distance. MD 68 crosses over the creek on a narrow stone bridge, then makes a sharp turn to the south to continue following the forested valley of the creek. The state highway crosses over Beaver Creek on a one-lane stone bridge before leaving the creek valley. MD 68 continues southeast through farmland and the hamlet of Millpoint before reaching its eastern terminus at US 40 Alternate (Main Street) on the northern edge of the town of Boonsboro.
