 After earning his doctorate, Clough began his academic career as an assistant professor at Duke University in 1969. He joined the faculty at Stanford University in 1974 first as an associate professor and then later as full professor. In 1982, he joined the faculty of Virginia Tech as a professor of civil engineering and served as head of their Department of Civil Engineering for seven years. In 1990, Clough became dean of the Virginia Tech College of Engineering. Clough continued his research and instruction of graduate students at Virginia Tech in addition to his administrative responsibilities. Clough's research focused on geotechnical engineering, including earthquake studies, numerical analysis, soil structure interaction, in-situ testing, and underground openings. In 1993, he became provost and vice president for academic affairs at the University of Washington. Clough cofounded the United States Universities Council of Geotechnical Engineering Research (USUCGER), and served as the organization's first president during 1993.
