 Niki Payne of the Philadelphia Examiner said "Eat, Pray, Queef" was "probably one of my all-time favorite episodes of South Park right now" because it was so on point concerning the double standards between men and women. She particularly praised the scene in which Stan and Randy are disgusted and uncomfortable when Stan's mom and sister started queefing at the dinner table. Carlos Delgado of If Magazine said the episode was "shocking, disgusting and obscenely funny" and demonstrated South Park's ability to tackle any type of issue "in a uniquely South Park manner". He particularly enjoyed the Martha Stewart segment, which he described as "just haunting". Josh Modell of The A.V. Club gave the episode a B grade. Modell said the Katie and Katherine cartoon was particularly funny, but queefing was referred to in so many jokes that it became a bit tired by the end.
