 Historically a part of Lancashire, there are records of Didsbury existing as a small hamlet as early as the 13th century. Its early history was dominated by being part of the Manor of Withington, a feudal estate that covered a large part of what is now the south of Manchester. Didsbury was described during the 18th century as a township separate from outside influence. In 1745 Charles Edward Stuart crossed the Mersey at Didsbury in the Jacobite march south from Manchester to Derby, and again in the subsequent retreat.
