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You searched for subject:(Liver). Showing records 1 – 10 of 10 total matches.
 1. Mėginis, Jonas. Lietuvoje galvijų gydymui naudojamų vaistų likučių patekimo į maistą rizika.
 URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100610_142256-41588 ;
 Maisto produktuose, gaminamuose iš veterinariniais vaistais gydytų gyvūnų gali likti tų vaistų likučių, kurie vartojami su maistu gali kenkti žmonių sveikatai. Siekiant apsaugoti visuomenės sveikatą,... (more)
 Maisto produktuose, gaminamuose iš veterinariniais vaistais gydytų gyvūnų gali likti tų vaistų likučių, kurie vartojami su maistu gali kenkti žmonių sveikatai. Siekiant apsaugoti visuomenės sveikatą, visuotinai pripažintais saugos įvertinimo principais, atsižvelgiant į mokslo pasiekimus nustatomi didžiausi likučių kiekiai įvairiuose gyvūninės kilmės produktuose, įskaitant mėsą, žuvį, pieną, kiaušinius ir medų. ES šalys įpareigotos kontroliuoti veterinarinių vaistų likučių kiekius gyvūninės kilmės produktuose, vertinti jų patekimo į maistą riziką. Tai atliekama vykdant nacionalines gyvūninės kilmės produktų stebėsenos programas. Veterinarinių vaistų likučių nustatymas vienas iš sudėtingiausių analizės objektų. Veterinarinius vaistus, taip pat kitus teršalus reikalaujama aptikti mikrogramų, ar net jų dalių kilograme eilės koncentracijose. Analizės metodai šiose srityse reikalauja vis pažangesnės aparatūros, o taip pat griežtesnių metodų įvertinimo procedūrų, savu ruožtu užtikrinančių atliekamų tyrimų kokybę. Ne pakankamai tiksliai identifikavus teršalą, ar jo kiekį gali nukentėti tiek gamintojas, tiek vartotojas, ant kurio stalo atsidurs užterštas maisto produktas. Lietuvoje taip pat pastoviai vykdoma gyvūninės kilmės produktų taršos stebėsena, kur pagrindinis dėmesys skiriamas vaistų likučių kontrolei. Darbo tikslas: Įvertinti Lietuvoje galvijų gydymui naudojamų vaistų likučių patekimo į gyvūninės kilmės produkciją galimybę ir riziką. Uždaviniai: 1. Apžvelgti literatūros... [toliau žr. visą tekstą]
 Aim of study – evaluate the treatment of animals used drug residues access to bovine production possibility and risk in Lithuania. In raw milk most often found the penicillin and tetracycline residues and banned the use of treatment chloramphenicol. In muscle of bovine mostly are found sulfonamides, tetracyclines and NSAID's groups substances. In liver of bovine residues of veterinary medicines in quantities exceeding the maximum allowable concentrations not have been found. In kidney of bovine, quantities exceeding the maximum allowable concentration, were determined enrofloxacin and quinolones. Analyse the results not relate statistically significant correlation between the number of tested samples and they found to contain residues of veterinary medicines in quantities exceeding the maximum limit of the number. On purpose to better and more accurately assess animal products pollution veterinary medicinal residue, them is not appropriate to divide into categories: „ less maximum residue levels ", or " more maximum residue levels " but collect information about found on of the cases in which not exceeding the maximum residue levels for veterinary drug residue limits.
 Advisors/Committee Members: Stanevičius, Zenonas (Master’s degree committee chair), Petkevičius, Saulius (Master’s degree committee member), Lukoševičius, Leonardas (Master’s degree committee member), Zaborskienė, Gintarė (Master’s degree committee member), Sekmokienė, Dalia (Master’s degree committee member), Malakauskas, Mindaugas (Master’s degree committee member), Matusevičius, Algimantas (Master’s degree committee member), Vaitkevičienė, Milda (Master’s degree session secretary), Milius, Jonas (Master’s thesis supervisor), Matusevičius, Algimantas (Master’s thesis reviewer).
 Subjects/Keywords: Vaistų likučiai; Pienas; Kepenys; Inkstai; Drug residues; Milk; Liver; Kidneys
 Mėginis, Jonas. (2010). Lietuvoje galvijų gydymui naudojamų vaistų likučių patekimo į maistą rizika . (Masters Thesis). Lithuanian Veterinary Academy. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100610_142256-41588 ;
 Mėginis, Jonas. “Lietuvoje galvijų gydymui naudojamų vaistų likučių patekimo į maistą rizika.” 2010. Masters Thesis, Lithuanian Veterinary Academy. Accessed July 18, 2019. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100610_142256-41588 ;.
 Mėginis, Jonas. “Lietuvoje galvijų gydymui naudojamų vaistų likučių patekimo į maistą rizika.” 2010. Web. 18 Jul 2019.
 Mėginis, Jonas. Lietuvoje galvijų gydymui naudojamų vaistų likučių patekimo į maistą rizika. [Internet] [Masters thesis]. Lithuanian Veterinary Academy; 2010. [cited 2019 Jul 18]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100610_142256-41588 ;.
 Mėginis, Jonas. Lietuvoje galvijų gydymui naudojamų vaistų likučių patekimo į maistą rizika. [Masters Thesis]. Lithuanian Veterinary Academy; 2010. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100610_142256-41588 ;
 2. Pukenytė, Evelina. Veiksniai, sąlygojantys vaistų nuo tuberkuliozės sukeliamą kepenų pažeidimą, gydant živ infekuotus ir neinfekuotus aktyvia tuberkulioze sergančius pacientus.
 URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2007~D_20080129_145950-51261 ;
 Bendros nuomonės vertinant rizikos veiksnius, sąlygojančius kepenų pažeidimą gydant vaistais nuo tuberkuliozės ŽIV infekuotus ir neinfekuotus pacientus, sergančius tuberkulioze, nėra. ŽIV infekcijos įtaka šiam pažeidimui... (more)
 Bendros nuomonės vertinant rizikos veiksnius, sąlygojančius kepenų pažeidimą gydant vaistais nuo tuberkuliozės ŽIV infekuotus ir neinfekuotus pacientus, sergančius tuberkulioze, nėra. ŽIV infekcijos įtaka šiam pažeidimui atsirastinėra išaiškinta. Daugelis darbų atlikta su nedideliu ŽIV infekuotų pacientų skaičiumi ir gauti rezultatai yra skirtingi. Darbo tikslas Nustatyti rizikos veiksnius, sąlygojančius sunkaus kepenų pažeidimo atsiradimą gydant vaistais nuo tuberkuliozės pirmus du tuberkuliozės gydymo mėnesius ŽIV infekuotus ir neinfekuotus ligonius, sergančius aktyvia tuberkulioze, taip pat nustatyti šio pažeidimo pasireiškimo dažnį bei pažeidimo atsiradimo laiką. Darbo uždaviniai 1. Išnagrinėti tuberkulioze sergančių bei gydomų nuo tuberkuliozės ligonių demografines, klinikines ypatybes bei kai kurių laboratorinių tyrimų duomenis tuberkuliozės gydymo pradžioje. 2. Nustatyti bei palyginti kepenų pažeidimo pasireiškimo dažnį bei atsiradimo laiką gydant vaistais nuo tuberkuliozės ŽIV infekuotus ir neinfekuotus pacientus. 3. Nustatyti ir palyginti demografinius, laboratorinius ir klinikinius rizikos veiksnius, galinčius turėti įtakos sunkiam kepenų pažeidimui atsirasti gydant vaistais nuo tuberkuliozės pirmus du tuberkuliozės gydymo mėnesius ŽIV infekuotus ir neinfekuotus ligonius. 4. Nustatyti vaistų, kurie pradėti vartoti kartu su per pirmą savaitę paskirtais vaistais nuo tuberkuliozės, įtaką kepenų pažeidimui atsirasti.
 Although there are many hepatotoxicity risk factors describe for patients on antituberculosis therapy. However, the risk factors for liver injury and its occurence during this antituberculosis therapy have been assessed in HIV non-infected patients, they have rarely been assessed in HIV-infected patients, especially those treated for active tuberculosis. Most studies with HIV-infected patients on antituberculosis therapy have been carried out with a small amount of HIV-infected patients and results received are different. Aims and objectives The aim of this study is therefore to evaluate the incidence of severe liver injury in HIV-infected and non-infected patients on antituberculosis therapy, the time to its occurrence, and the clinical, biological and therapeutic risk factors for this injury. The objectives were as follows: 1. To investigate into demographic, clinical particularities and laboratory data of patients on antituberculosis treatment. 2. To define and compare the incidence of severe liver injury as well as the time of these occurrence in HIV-infected and non-infected patients on antituberculosis treatment. 3. To define and compare demographic, biological and clinical risk factors for severe liver injury in HIV-infected and non-infected patients on antituberculosis treatment within the first two month of this therapy. 4. To define the impact on liver injury occurrence of medications used in the first week of the tuberculosis treatment.
 Advisors/Committee Members: Laiškonis, Alvydas Pranas (Doctoral dissertation supervisor), Ulozas , Virgilijus (Doctoral dissertation committee member), Kupčinskas, Limas (Doctoral dissertation committee chair), Malakauskas, Kęstutis (Doctoral dissertation committee member), Sakalauskas , Raimundas (Doctoral dissertation advisor), Yazdanpanah , Yazdan (Doctoral dissertation advisor), Ambrozaitis , Arvydas (Doctoral dissertation committee member), Petkevičius , Saulius (Doctoral dissertation committee member), Pavilonis , Alvydas (Doctoral dissertation opponent), Šiugždaitė , Jūratė (Doctoral dissertation opponent).
 Subjects/Keywords: Tuberkuliozė; ŽIV; Kepenų pažeidimas; Tuberculosis; HIV; Liver injury
 Pukenytė, E. (2008). Veiksniai, sąlygojantys vaistų nuo tuberkuliozės sukeliamą kepenų pažeidimą, gydant živ infekuotus ir neinfekuotus aktyvia tuberkulioze sergančius pacientus . (Doctoral Dissertation). Kaunas University of Medicine. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2007~D_20080129_145950-51261 ;
 Pukenytė, Evelina. “Veiksniai, sąlygojantys vaistų nuo tuberkuliozės sukeliamą kepenų pažeidimą, gydant živ infekuotus ir neinfekuotus aktyvia tuberkulioze sergančius pacientus.” 2008. Doctoral Dissertation, Kaunas University of Medicine. Accessed July 18, 2019. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2007~D_20080129_145950-51261 ;.
 Pukenytė, Evelina. “Veiksniai, sąlygojantys vaistų nuo tuberkuliozės sukeliamą kepenų pažeidimą, gydant živ infekuotus ir neinfekuotus aktyvia tuberkulioze sergančius pacientus.” 2008. Web. 18 Jul 2019.
 Pukenytė E. Veiksniai, sąlygojantys vaistų nuo tuberkuliozės sukeliamą kepenų pažeidimą, gydant živ infekuotus ir neinfekuotus aktyvia tuberkulioze sergančius pacientus. [Internet] [Doctoral dissertation]. Kaunas University of Medicine; 2008. [cited 2019 Jul 18]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2007~D_20080129_145950-51261 ;.
 Pukenytė E. Veiksniai, sąlygojantys vaistų nuo tuberkuliozės sukeliamą kepenų pažeidimą, gydant živ infekuotus ir neinfekuotus aktyvia tuberkulioze sergančius pacientus. [Doctoral Dissertation]. Kaunas University of Medicine; 2008. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2007~D_20080129_145950-51261 ;
 3. Juškevičiūtė, Eglė. Transkripcinis ankstyvojo kepenų regeneracijos tarpsnio reguliavimas.
 URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090312_110419-54442 ;
 Infekcijos, toksinų ar fizinių veiksnių pažeistos kepenys gali gana greitai atstatyti prarastą audinio masę. Mitozė vyksta tik labai nedidelėje suaugusio organizmo kepenų ląstelių dalyje. Tačiau... (more)
 Infekcijos, toksinų ar fizinių veiksnių pažeistos kepenys gali gana greitai atstatyti prarastą audinio masę. Mitozė vyksta tik labai nedidelėje suaugusio organizmo kepenų ląstelių dalyje. Tačiau sumažėjus kepenų masei hepatocitai ima sparčiai proliferuoti. Kepenų gebėjimą regeneruoti lemia sudėtinga augimo veiksnių, citokinų ir kitų ląstelės veiklą reguliuojančių junginių sąveika. Šiame darbe buvo tiriami genų raiškos pokyčiai žiurkės kepenų ląstelėse pradiniame kepenų regeneracijos tarpsnyje. Genų raiškai nustatyti buvo panaudotos DNR mikrogardelės. Buvo nustatyti 309 genai, kurių raiška patikimai pakinta per pirmąsias 6 valandas po dalinės hepatektomijos operacijos. Nustatytieji 309 genai buvo suskirstyti į šešias grupes pagal laikinius raiškos pokyčius. PAINT programos pagalba buvo nustatyti 22 transkripcijos veiksniai, galimai lemiantys laikinius genų raiškos pokyčius po dalinės hepatektomijos operacijos. Devynių transkripcijos veiksnių (NF-κB, GATA-1, HNF-1, C/EBP-α ir C/EBP-β, STAT-3, PAX-6, AP-2α ) aktyvumo pokyčiai buvo įvertinti eksperimentiškai. Nustatyta, kad aktyvių NF-κB, HNF-1 ir C/EBP-β kiekis hepatocitų branduoliuose staigiai padidėja po dalinės hepatektomijos operacijos. Priešingai, aktyvios C/EBP-α formos kiekis sumažėja. Chromatino imunoprecipitacijos (ChIP) metodu buvo tiriamas NF-κB jungimasis prie Sod2, Mt1a ir Cebpb promotorių sričių praėjus 1 valandai po hepatektomijos. Regeneruojančių kepenų mėginiuose rasta daugiau NF-κB prisijungusio prie Sod2 ir Mt... [toliau žr. visą tekstą]
 Liver possesses the capacity to restore its tissue mass and attain optimal volume in response to physical, infectious and toxic injury. The extraordinary ability of liver to regenerate is the effect of cross-talk between growth factors, cytokines, matrix components and many other factors. Adult liver normally has a very low level of hepatocyte cell division. However, most hepatocytes will rapidly proliferate in response to liver mass reduction. In this study the differences in gene expression in rat liver at 1, 2, 4 and 6 hours after the partial hepatectomy were analyzed using cDNA microarrays. These time points correspond to quiescent liver and early G1 phase in this system. The experiments showed that 309 genes had significantly altered expression for at least one of the analyzed time-points. Differentially expressed genes were clustered according to their temporal expression profiles. PAINT analysis identified several TF binding sites (~20) enriched in specific individual expression patterns. We have obtained time series data on the activity of nine transcription factors (NF-κB, HNF-1, CREB, C/EBP-α, C/EBP-β, AP-2α, PAX-6, GATA-1, STAT-3) that were implicated in our analysis. An early transient activation of NF-κB, HNF-1 and C/EBP-β was observed. By contrast, C/EBP-α rapidly declined. Chromatin immunoprecipitation (ChIP) assay was performed to examine the binding of NF-κB to the promoter regions of Sod2, Mt1a and Cebpb. We see increased NF-κB binding to both Sod2 and Mt1a... [to full text]
 Advisors/Committee Members: Mildažienė, Vida (Doctoral dissertation supervisor), Hoek, Jan B. (Doctoral dissertation advisor), Meškys, Rolandas (Doctoral dissertation committee chair), Naučienė, Zita (Doctoral dissertation committee member), Paulauskas, Algimantas (Doctoral dissertation committee member), Gulbinas, Antanas (Doctoral dissertation committee member), Kadziauskas, Jurgis (Doctoral dissertation committee member), Skeberdis, Arvydas (Doctoral dissertation opponent), Daugelavičius, Rimantas (Doctoral dissertation opponent).
 Subjects/Keywords: Kepenų regeneracija; Genų raiška; Transkripcijos veiksniai; Liver regeneration; Gene expression; Transcription factors
 Juškevičiūtė, E. (2009). Transkripcinis ankstyvojo kepenų regeneracijos tarpsnio reguliavimas . (Doctoral Dissertation). Vytautas Magnus University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090312_110419-54442 ;
 Juškevičiūtė, Eglė. “Transkripcinis ankstyvojo kepenų regeneracijos tarpsnio reguliavimas.” 2009. Doctoral Dissertation, Vytautas Magnus University. Accessed July 18, 2019. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090312_110419-54442 ;.
 Juškevičiūtė, Eglė. “Transkripcinis ankstyvojo kepenų regeneracijos tarpsnio reguliavimas.” 2009. Web. 18 Jul 2019.
 Juškevičiūtė E. Transkripcinis ankstyvojo kepenų regeneracijos tarpsnio reguliavimas. [Internet] [Doctoral dissertation]. Vytautas Magnus University; 2009. [cited 2019 Jul 18]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090312_110419-54442 ;.
 Juškevičiūtė E. Transkripcinis ankstyvojo kepenų regeneracijos tarpsnio reguliavimas. [Doctoral Dissertation]. Vytautas Magnus University; 2009. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090312_110419-54442 ;
 4. Žūkienė, Rasa. Hipertermijos poveikio mitochondrijų oksidacinio fosforilinimo sistemai tyrimas.
 Degree: Dissertation, Biochemistry, 2008, Vytautas Magnus University
 URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2008~D_20080721_124917-64300 ;
 Ląstelių atsako į nuosaikią hipertermiją molekulinio mechanizmo išaiškinimas yra labai svarbus norint suprasti procesus, kurie vyksta ląstelėse jas kaitinant gydymo tikslais ar organizmui karščiuojant. Šio... (more)
 Ląstelių atsako į nuosaikią hipertermiją molekulinio mechanizmo išaiškinimas yra labai svarbus norint suprasti procesus, kurie vyksta ląstelėse jas kaitinant gydymo tikslais ar organizmui karščiuojant. Šio darbo tikslas buvo nustatyti ir palyginti švelnios (karščiavimo) ir šiurkščios hipertermijos poveikį oksidacinės fosforilinimo sistemos funkcijoms normalių audinių mitochondrijose. Pirmą kartą panaudojome modulių kinetinę analizę hipertermijos poveikiui širdies ir kepenų mitochondrijų oksidacinio fosforilinimo sistemai tirti. Mes nustatėme, kad švelnios hipertermijos (42 oC) poveikis širdies mitochondrijų funkcijoms yra grįžtamas, bet šiurkštesnė hipertermija (45 oC) sukelia dalinai negrįžtamą kvėpavimo ir fosforilinimo atskyrimą bei mitochondrijų kvėpavimo greičio trečioje metabolinėje būsenoje slopinimą. Hipertermija didino ROS gamybos greitį ir lipidų peroksidaciją, kurie buvo didžiausi karščiavimo temperatūroje. Nustatėme, kad kepenų mitochondrijų ir hepatocitų atsakas į hipertermiją priklauso nuo žiurkės lyties ir temperatūros. Atlikome palyginamąjį širdies ir kepenų mitochondrijų sandų fazinių virsmų analizę diferencine skenuojamaja kalorimetrija ir nustatėme būdingus skirtumus.
 The elucidation of the molecular mechanism of the cell response to moderate heating is of importance for understanding the events that occur in the cell upon use of heating for therapeutic purpose or during illnesses that are associated with fever. The aim of this work was to investigate and to compare the effects of mild (fever) and severe hyperthermia on functional properties of oxidative phosphorylation system in normal tissue mitochondria. Modular kinetic analysis for the first time was applied to evaluate effects of hyperthermia on oxidative phosphorylation in rat heart and liver mitochondria. We demonstrated that changes in mitochondrial functions induced by mild hyperthermia (42 oC) are reversible but more severe hyperthermia (45 oC) causes partially irreversible uncoupling and inhibition of mitochondrial respiration in state 3, hyperthermia remarkably (3.6-2.1 fold) activates ROS generation in heart mitochondria and that maximal increase in rate of H2O2 production and lipid peroxidation is observed in the fever temperature range. We show that the response of liver mitochondria and hepatocytes to hyperthermia is to certain extent dependent on gender and temperature. Specific differences of male rat liver and heart mitochondrial components phase transitions have been revealed by DSC analysis.
 Advisors/Committee Members: Mildaziene, Vida (Doctoral dissertation supervisor), Meškys, Romualdas (Doctoral dissertation committee chair), Saulis, Gintautas (Doctoral dissertation committee member), Kadziauskas, Jurgis (Doctoral dissertation committee member), Skeberdis, Vytenis Arvydas (Doctoral dissertation committee member), Morkūnienė, Ramunė (Doctoral dissertation committee member), Toleikis, Adolfas (Doctoral dissertation opponent), Daugelavičius, Rimantas (Doctoral dissertation opponent).
 Subjects/Keywords: Hipertermija; Širdies mitochondrijos; Kepenų mitochondrijos; Oksidacinis fosforilinimas; Hyperthermia; Heart mitochondria; Liver mitochondria; Oxidative phosphorylation
 Žūkienė, Rasa. (2008). Hipertermijos poveikio mitochondrijų oksidacinio fosforilinimo sistemai tyrimas . (Doctoral Dissertation). Vytautas Magnus University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2008~D_20080721_124917-64300 ;
 Žūkienė, Rasa. “Hipertermijos poveikio mitochondrijų oksidacinio fosforilinimo sistemai tyrimas.” 2008. Doctoral Dissertation, Vytautas Magnus University. Accessed July 18, 2019. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2008~D_20080721_124917-64300 ;.
 Žūkienė, Rasa. “Hipertermijos poveikio mitochondrijų oksidacinio fosforilinimo sistemai tyrimas.” 2008. Web. 18 Jul 2019.
 Žūkienė, Rasa. Hipertermijos poveikio mitochondrijų oksidacinio fosforilinimo sistemai tyrimas. [Internet] [Doctoral dissertation]. Vytautas Magnus University; 2008. [cited 2019 Jul 18]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2008~D_20080721_124917-64300 ;.
 Žūkienė, Rasa. Hipertermijos poveikio mitochondrijų oksidacinio fosforilinimo sistemai tyrimas. [Doctoral Dissertation]. Vytautas Magnus University; 2008. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2008~D_20080721_124917-64300 ;
 5. Klusavičiūtė, Kristina. Sunkiųjų metalų poveikio metalotioneinų sintezei ir lipidų peroksidacijai laboratorinių pelių organuose įvertinimas.
 Degree: Master, Biochemistry, 2012, Lithuanian Academic Libraries Network (LABT)
 URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120612_162632-64837 ;
 Atlikto darbo tikslas buvo įvertinti kadmio, nikelio bei cinko jonų poveikį metalotioneinų sintezės intensyvumui ir lipidų peroksidacijai laboratorinių pelių organuose – kepenyse ir smegenyse. Šiam... (more)
 Atlikto darbo tikslas buvo įvertinti kadmio, nikelio bei cinko jonų poveikį metalotioneinų sintezės intensyvumui ir lipidų peroksidacijai laboratorinių pelių organuose – kepenyse ir smegenyse. Šiam tikslui įgyvendinti buvo iškelti uždaviniai: nustatyti metalotioneinų koncentraciją pelių smegenyse ir kepenyse po vienkartinio (24 val.) ir kartotinio (14 dienų) kadmio ir nikelio jonų poveikio; įvertinti ūmų vienkartinį (24 val.) ir kartotinį (14 dienų) kadmio ir nikelio jonų poveikį lipidų peroksidacijai pelių smegenyse ir kepenyse; įvertinti cinko jonų gebą apsaugoti smegenų ir kepenų antioksidacinę sistemą esant toksiniam kadmio ir nikelio jonų poveikiui. Eksperimentams atlikti naudotos baltosios beveislės laboratorinės pelės. Metalotioneinų koncentracija nustatatyta pagal Peixoto ir bendraautorių, o malondialdehido – pagal Uchiyama ir bendraautorių pasiūlytas metodikas. Tyrimo rezultatai parodė, kad tiek kadmio, tiek ir nikelio jonai pelių kepenyse metalotioneinų koncentracijos padidėjimą sukėlė ir po vienkartinio 24 val., ir po kartotinio 14 dienų šių jonų poveikio, o smegenyse – tik praėjus 24 valandoms po kadmio ar nikelio jonų poveikio. Cinko jonai veikdami kartu su kadmio jonais statistiškai reikšmingą metalotioneinų koncentracijos padidėjimą sukėlė smegenyse po 14 dienų šių jonų kompleksinio poveikio. Cinko jonams veikiant kartu su nikelio jonais, statistiškai reikšmingas metalotioneinų koncentracijos padidėjimas taip pat nustatytas smegenyse po 14 dienų šių jonų... [toliau žr. visą tekstą]
 The aim of the work was to evaluate the influance of cadmium, nickel and zinc ions on metallothionein synthesis and lipid peroxidation intensity in mice organs – the liver and brain. The tasks of the work were: to determine the concentration of MT in mice brain and liver after both acute (24 hours) and repeated (14 days) influence of cadmium and nickel ions, to evaluate the acute (24 hours) and repeated (14 days) effects of cadmium and nickel ions on lipid peroxidation in mouse brain and liver and to evaluate the ability of zinc ion to protect the brain and liver antioxidant system from the toxicity of cadmium and nickel ions. We used white laboratory mice in our experiments. MT concentration was established according to Peixot and contributors proposed method and MDA concentration – according to Uchiyama and contributors proposed method. The results have shown that both cadmium and nickel ions increased metallothionein concentration in the liver of mice after a single (24 hours) and after repeated (14 days) exposure of these ions. The increased metallothionein concentration in the brain was established only 24 hours after cadmium or nickel ions exposure. Zinc ions in cooperation with the cadmium ions a statistically significant increase of metallothionein levels caused in the brain 14 days after the complex effects of these ions. Zinc ions, acting with the nickel ions, a statistically significant increase of metallothionein concentration caused as well in the brain after 14... [to full text]
 Advisors/Committee Members: Sadauskienė, Ilona (Master’s thesis supervisor), Jakštas, Valdas (Master’s degree committee chair), Savickas, Arūnas (Master’s degree committee member), Janulis, Valdimaras (Master’s degree committee member), Ivanauskas, Liudas (Master’s degree committee member), Rodovičius, Hiliaras (Master’s degree committee member), Radžiūnas, Raimondas (Master’s degree committee member), Briedis, Vitalis (Master’s degree committee member), Pečiūra, Rimantas (Master’s degree committee member), Gumbrevičius, Gintautas (Master’s degree committee member), Martinėnas, Žydrūnas (Master’s degree committee member), Stanevičienė, Inga (Master’s thesis reviewer).
 Subjects/Keywords: Oksidacinis stresas; Smegenys; Kepenys; Metalotioneinai; Malondialdehidas; Oxidative stress; Brain; Liver; Matallothionein; Malondialdehyde
 Klusavičiūtė, Kristina. (2012). Sunkiųjų metalų poveikio metalotioneinų sintezei ir lipidų peroksidacijai laboratorinių pelių organuose įvertinimas . (Masters Thesis). Lithuanian Academic Libraries Network (LABT). Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120612_162632-64837 ;
 Klusavičiūtė, Kristina. “Sunkiųjų metalų poveikio metalotioneinų sintezei ir lipidų peroksidacijai laboratorinių pelių organuose įvertinimas.” 2012. Masters Thesis, Lithuanian Academic Libraries Network (LABT). Accessed July 18, 2019. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120612_162632-64837 ;.
 Klusavičiūtė, Kristina. “Sunkiųjų metalų poveikio metalotioneinų sintezei ir lipidų peroksidacijai laboratorinių pelių organuose įvertinimas.” 2012. Web. 18 Jul 2019.
 Klusavičiūtė, Kristina. Sunkiųjų metalų poveikio metalotioneinų sintezei ir lipidų peroksidacijai laboratorinių pelių organuose įvertinimas. [Internet] [Masters thesis]. Lithuanian Academic Libraries Network (LABT); 2012. [cited 2019 Jul 18]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120612_162632-64837 ;.
 Klusavičiūtė, Kristina. Sunkiųjų metalų poveikio metalotioneinų sintezei ir lipidų peroksidacijai laboratorinių pelių organuose įvertinimas. [Masters Thesis]. Lithuanian Academic Libraries Network (LABT); 2012. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120612_162632-64837 ;
 6. Čičinskaitė, Ilona. Ūminio ir lėtinio paūmėjusio kepenų funkcijos nepakankamumo priežastys, išeitys ir prognozės kriterijai.
 URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2005~D_20060105_114953-62440 ;
 ► Acute liver failure (ALF) is a rather rare clinical syndrome developing due to an acute massive dysfunction of the liver cells in previously healthy persons... (more)
 ▼ Acute liver failure (ALF) is a rather rare clinical syndrome developing due to an acute massive dysfunction of the liver cells in previously healthy persons (at least 8 weeks there was no diagnosis of any liver disease) resulting in rapidly progressing multiple organ dysfunction syndrome. Without liver transplantation 80-95 % of the patients die. Factors, influencing the outcome are etiology, the patient's age and the course of the disease. Spontaneous recovery, however, is possible in 5-60 % of ALF cases when regeneration of the liver starts, therefore the main goal of the treatment is to create the most favorable conditions for regeneration. Causes of ALF may be different. The most common cause of ALF is viral hepatitis, but the prevailing causative agent of hepatitis is different in different countries. Drug-induced (acetaminophen, halotane) liver dysfunction ranks second. The order of other etiological factors according to their frequency is: mushroom (Amanita) poisoning, carbon tetrachloride toxicity, heat stroke, synthetic amphetamine ("Ecstasy") and disorders of liver blood vessels. In cases of unfavorable prognosis for patients with ALF the only method of treatment with good prognosis is liver transplantation (LT). From 50 to 70 % of patients with lethal ALF prognosis survive after emergency LT. There is no unified ALF prognostic system or indications for LT in the world, therefore a precise individual prognosis for every patient and well-timed decision about LT are... [to full text] Advisors/Committee Members: Jonaitis, Laimas Virgilijus (Doctoral dissertation opponent), Pilvinis, Vidas (Doctoral dissertation supervisor), Maleckas, Almantas (Doctoral dissertation committee member), Kiudelis, Gediminas (Doctoral dissertation committee member), Šipylaitė, Jūratė (Doctoral dissertation committee member), Vosylius, Saulius (Doctoral dissertation opponent), Braždžionytė, Julija (Doctoral dissertation committee chair), Petkevičius, Saulius (Doctoral dissertation committee member).
 Subjects/Keywords: Acute-on-chronic liver failure; Acute liver failure; Manganas; Liver transplantation; Manganese; Lėtinis paūmėjęs kepen�� funkcijos nepakankamumas; Kepenų transplantacija; Prognozės kriterijai; Ūminis kepenų funkcijos nepakankamumas; Prognostic criteria
 Čičinskaitė, I. (2006). Ūminio ir lėtinio paūmėjusio kepenų funkcijos nepakankamumo priežastys, išeitys ir prognozės kriterijai . (Doctoral Dissertation). Kaunas University of Medicine. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2005~D_20060105_114953-62440 ;
 Čičinskaitė, Ilona. “Ūminio ir lėtinio paūmėjusio kepenų funkcijos nepakankamumo priežastys, išeitys ir prognozės kriterijai.” 2006. Doctoral Dissertation, Kaunas University of Medicine. Accessed July 18, 2019. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2005~D_20060105_114953-62440 ;.
 Čičinskaitė, Ilona. “Ūminio ir lėtinio paūmėjusio kepenų funkcijos nepakankamumo priežastys, išeitys ir prognozės kriterijai.” 2006. Web. 18 Jul 2019.
 Čičinskaitė I. Ūminio ir lėtinio paūmėjusio kepenų funkcijos nepakankamumo priežastys, išeitys ir prognozės kriterijai. [Internet] [Doctoral dissertation]. Kaunas University of Medicine; 2006. [cited 2019 Jul 18]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2005~D_20060105_114953-62440 ;.
 Čičinskaitė I. Ūminio ir lėtinio paūmėjusio kepenų funkcijos nepakankamumo priežastys, išeitys ir prognozės kriterijai. [Doctoral Dissertation]. Kaunas University of Medicine; 2006. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2005~D_20060105_114953-62440 ;
 7. Vanagas, Tomas. Procesų, įtakojančių radiodažninės abliacijos kepenų audinyje rezultatus, tyrimas.
 Degree: Dissertation, Medicine, 2011, Lithuanian Academic Libraries Network (LABT)
 URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110601_114529-55749 ;
 Vienas iš būdų padėti pacientams, sergantiems kepenų navikais, yra lokalus naviko sunaikinimas radiodažnine abliacija. Pagrindine šio metodo problema išlieka aukštas naviko atkryčio dažnis. Disertacijos tikslas... (more)
 Vienas iš būdų padėti pacientams, sergantiems kepenų navikais, yra lokalus naviko sunaikinimas radiodažnine abliacija. Pagrindine šio metodo problema išlieka aukštas naviko atkryčio dažnis. Disertacijos tikslas yra ištirti procesus, vykstančius radiodažnine abliacija paveiktame kepenų audinyje, išsiaiškinti šių procesų mechanizmus bei hipertermijos sąlygojamus pakitimus audinio, ląstelės ir subląsteliniame lygmenyje. Retrospektyviu tyrimu įvertintas pacientų, kuriems KMUK Chirurgijos klinikoje buvo atlikta kepenų navikų radiodažninė abliacija, navikų atkryčio dažnis, jo atsiradimo laikas ir veiksniai, galintys sąlygoti atkrytį. Eksperimentiškai įvertinti fizikiniai veiksniai, sąlygojantys šilumos plitimą kepenų audinyje, jų įtaka kepenų audinio pažeidimo mąstui ir tolygumui. Nustatyti morfologiniai ir biocheminiai pakitimai, vykstantys pereinamojoje kepenų audinio pažeidimo zonoje, bei šių pakitimų atsiradimo laikas. Ištirti pereinamosios kepenų audinio pažeidimo zonos hepatocitų mitochondrijų funkcijų pokyčiai ir apoptozės proceso vyksmui reikalingų energetinių resursų susidarymas, eksperimentiškai modeliuojant šios zonos temperatūrinius kitimus. Tyrimo naujumą lemia tai, kad darbe nustatyta jog apoptozės procesas pereinamoje radiodažninio pažeidimo zonoje gali būti nustatomas praėjus valandai po terminio pažeidimo. Eksperimentuose su hepatocitų mitochondrijomis nustatėme iki šiol neaprašytą neigiamą hipertermijos poveikį kepenų ląstelių mitochondrijų funkciniams rodikliams.
 Radiofrequency ablation is one of the most widely accepted method for the local ablation of liver tumors. One of the negative aspects of this method is a high local recurrence rate, which is associated with the worse survival. The aim of the dissertation was to explore the processes in radiofrequency ablation affected liver tissue, ascertain the mechanisms of these processes and hyperthermia induced changes in the liver tissue, cells and subcellular level. The liver tumor recurrence rate, time and factors that could determine the recurrence were estimated using retrospective analysis of data. The physical parameters determining the spreading of the heat in liver tissue in experimental model and the influence of these parameters on extent and homogeneity of the damage were determined. The morphological and biochemical changes in the remote from the heat source zone were determined and the time of these changes was detected. The changes of liver cells mitochondria functions and the intracellular formation of energy resources necessary for these processes in subcellular level (apoptosis) were investigated simulating temperature changes in experimental model. The scientific novelty was governed by the data those support the activation of apoptotic pathway in the early period after exposure to hyperthermia. Our experimental study revealed yet unpublished data of the adverse effects of hyperthermia on the key functional parameters of the mitochondria.
 Advisors/Committee Members: Barauskas, Giedrius (Doctoral dissertation supervisor), Endzinas, Žilvinas (Doctoral dissertation committee chair), Trumbeckaitė , Sonata (Doctoral dissertation committee member), Skurvydas , Albertas (Doctoral dissertation committee member), Jonaitis , Laimas (Doctoral dissertation committee member), Didžiapetrienė , Janina (Doctoral dissertation committee member), Mickevičius , Antanas (Doctoral dissertation opponent), Paulauskas , Algimantas (Doctoral dissertation opponent), Ulozas , Virgilijus (Doctoral dissertation opponent).
 Subjects/Keywords: Kepenų navikai; Radiodažninė abliacija; Atkrytis; Pereinamoji zona; Apoptozė; Liver tumors; Radiofrequency ablation; Recurrence; Transition zone; Apoptosis
 Vanagas, Tomas. (2011). Procesų, įtakojančių radiodažninės abliacijos kepenų audinyje rezultatus, tyrimas . (Doctoral Dissertation). Lithuanian Academic Libraries Network (LABT). Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110601_114529-55749 ;
 Vanagas, Tomas. “Procesų, įtakojančių radiodažninės abliacijos kepenų audinyje rezultatus, tyrimas.” 2011. Doctoral Dissertation, Lithuanian Academic Libraries Network (LABT). Accessed July 18, 2019. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110601_114529-55749 ;.
 Vanagas, Tomas. “Procesų, įtakojančių radiodažninės abliacijos kepenų audinyje rezultatus, tyrimas.” 2011. Web. 18 Jul 2019.
 Vanagas, Tomas. Procesų, įtakojančių radiodažninės abliacijos kepenų audinyje rezultatus, tyrimas. [Internet] [Doctoral dissertation]. Lithuanian Academic Libraries Network (LABT); 2011. [cited 2019 Jul 18]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110601_114529-55749 ;.
 Vanagas, Tomas. Procesų, įtakojančių radiodažninės abliacijos kepenų audinyje rezultatus, tyrimas. [Doctoral Dissertation]. Lithuanian Academic Libraries Network (LABT); 2011. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110601_114529-55749 ;
 8. Lukošaitienė, Inga. Pacientų, kuriems atlikta kepenų transplantacija, fizinė ir emocinė sveikata.
 URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130618_134045-87863 ;
 Lietuvoje vis daugiau atliekama kepenų transplantacijų. Šiuo metu pacientų išgyvenimas didėja, todėl atsiranda problema, kad slaugytojams, trūksta žinių ir informacijos apie fizinės ir emocinės sveikatos... (more)
 Lietuvoje vis daugiau atliekama kepenų transplantacijų. Šiuo metu pacientų išgyvenimas didėja, todėl atsiranda problema, kad slaugytojams, trūksta žinių ir informacijos apie fizinės ir emocinės sveikatos problemas kylančias pacientams, kuriems yra atlikta kepenų transplantacija. Gastroenterologijos skyriaus slaugytojų, kurios slaugo pacientus po atliktos kepenų transplantacijos, vienas iš slaugos tikslų yra skatinti pacientus dalyvauti slaugoje bei siekti sveikatą skatinančio elgesio. Atlikus tyrimą bus išsiaiškinta, kokios fizinės ir emocinės sveikatos problemos kyla pacientams, kuriems atlikta kepenų transplantacija. Suprasdami ir žinodami šiems pacientams kylančias problemas, slaugytojai galės geriau planuoti slaugą, pasitelkti į pagalbą kitus specialistus. Darbo tikslas – atskleisti, kokia yra pacientų, kuriems atlikta kepenų transplantacija, fizinė ir emocinė sveikata. Šiam tikslui pasiekti buvo pasirinktas atlikti kokybinis tyrimas. Kokybinio tyrimo klausimas: Kokia yra pacientų, kuriems atlikta kepenų transplantacija, fizinė ir emocinė sveikata? Tyrimo objektas – pacientų, kuriems atlikta kepenų transplantacija, fizinė ir emocinė sveikata. Tyrimo priemonė – pusiau struktūruotas interviu. Tyrimo dalyviai – pacientai, kuriems atlikta kepenų transplantacija ne mažiau kaip prieš du mėnesius. Tyrimo rezultatai atskleidė, kad: 1. Pacientams po atliktos kepenų transplantacijos iškilo naujų fizinės sveikatos problemų susijusių su atsiradusiu cukriniu diabetu, padidėjusiu... [toliau žr. visą tekstą]
 Every year more and more liver transplantations are performed in Lithuania.these days more Patients trial these operations and this creates a problem that nursing staff lacks informatikon about physical and emotional healtcare problems that these Patients face. One of the tasks for nursing staff of Gastroenterology divisions is to encourage Patients to participate in the nursing process and to promote Health-improving behavior. The research aims to help explaining what physical and emotional healthcare problems Patients face after liver transplantation. By knowing and understanding these problems nursing staff will have more tools in nursing planning and also will be able to ask for a timely help by other specialists. Goal of this thesis is to examine physical and emotional Health of Patients after liver transplantation. Qualitative method was chosed to implement this research. Key question of the research is: what is the physical and emotional Health of Patients after liver transplantation? Object of the research is physical and emotional Health of Patients after liver transplantation. Tool of the research is semi-structured interview. Respondents of the research are Patients who experienced liver transplantation not more than two month ago. Results of the research are the following: 1. Patients after liver transplantation face new physical healthcare problems related to diabetes, increased arterial blood presure, special diet, physical activity, smoking and consunning... [to full text]
 Advisors/Committee Members: Šumskienė, Jolanta (Master’s thesis supervisor), Vaškelytė, Alina (Master’s thesis reviewer), Macijauskienė , Jūratė (Master’s degree committee chair), Vaškelytė, Alina (Master’s degree committee member), Blaževičienė, Aurelija (Master’s degree committee member), Ustinavičienė, Rūta (Master’s degree committee member), Vainoras, Alfonsas (Master’s degree committee member), Zagurskienė, Daiva (Master’s degree committee member), Toliušienė, Jolanta (Master’s degree committee member).
 Subjects/Keywords: Kepenų transplantacija; Holizmo teorija; Sveikatos skatinimo slaugos modelis; Liver transplantation; Theory of holism; Health promotion model
 Lukošaitienė, Inga. (2013). Pacientų, kuriems atlikta kepenų transplantacija, fizinė ir emocinė sveikata . (Masters Thesis). Lithuanian Academic Libraries Network (LABT). Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130618_134045-87863 ;
 Lukošaitienė, Inga. “Pacientų, kuriems atlikta kepenų transplantacija, fizinė ir emocinė sveikata.” 2013. Masters Thesis, Lithuanian Academic Libraries Network (LABT). Accessed July 18, 2019. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130618_134045-87863 ;.
 Lukošaitienė, Inga. “Pacientų, kuriems atlikta kepenų transplantacija, fizinė ir emocinė sveikata.” 2013. Web. 18 Jul 2019.
 Lukošaitienė, Inga. Pacientų, kuriems atlikta kepenų transplantacija, fizinė ir emocinė sveikata. [Internet] [Masters thesis]. Lithuanian Academic Libraries Network (LABT); 2013. [cited 2019 Jul 18]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130618_134045-87863 ;.
 Lukošaitienė, Inga. Pacientų, kuriems atlikta kepenų transplantacija, fizinė ir emocinė sveikata. [Masters Thesis]. Lithuanian Academic Libraries Network (LABT); 2013. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130618_134045-87863 ;
 9. Silkauskaitė, Vilma. Kepenų venų spaudimo gradiento reikšmė vartų venos hipertenzijos diagnostikai bei medikamentinio gydymo efektyvumo įvertinimui sergantiems kepenų ciroze.
 URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20100422_102715-83882 ;
 Darbo tikslas buvo nustatyti vartų venos hipertenzijos (VVH) neinvazinių parametrų ir kepenų venų spaudimų gradiento ryšį, įvertinti medikamentinio gydymo efektyvumą mažinant VVH sergantiems kepenų ciroze.... (more)
 Darbo tikslas buvo nustatyti vartų venos hipertenzijos (VVH) neinvazinių parametrų ir kepenų venų spaudimų gradiento ryšį, įvertinti medikamentinio gydymo efektyvumą mažinant VVH sergantiems kepenų ciroze. Darbo uždaviniai - Nustatyti neinvazinių VVH požymių ryšį su kepenų venų spaudimų gradiento pakitimais (KVSG) ir įvertinti parametrus, rodančius kliniškai reikšmingą KVSG padidėjimą (≥12 mm Hg). - .Nustatyti veiksnius, susijusius su kraujavimu iš varikozinių stemplės venų. - Įvertinti ir palyginti karvedilolio ir nebivololio efektyvumą mažinant vartų venos hipertenziją kepenų ciroze sergantiems pacientams. Išvados 1.Didesnį KVSG parodo B, C klasės kepenų funkcijos nepakankamumas (pagal CTP), didelio laipsnio varikozinės stemplės venos (F2 ir F3) bei praeityje buvęs varikozinis kraujavimas. 2.Kliniškai reikšmingą KVSG padidėjimą (≥12 mm Hg) parodo protrombino indeksas, albumino kiekis serume, didesnis balų skaičius vertinant kepenų funkcijos nepakankamumą pagal CTP bei MELD sistemas. 3.Ultragarsu randamas sumažėjęs viršutinės pasaito arterijos pulsatiliškumo indeksas, monofazinė kepenų venų kraujotaka bei rekanalizuota bambinė vena parodo kliniškai reikšmingą KVSG padidėjimą. 4.Sergant kepenų ciroze, kraujavimas iš varikozinių stemplės venų yra susijęs su didelio (F2-F3) laipsnio išsiplėtusiomis stemplės venomis, KVSG ≥18 mm Hg, didesniu blužnies skersmeniu, lėtesniu maksimaliu kraujotakos greičiu kepenų venose. 5.Tiek karvedilolis, tiek nebivololis efektyviai sumažino KVSG... [toliau žr. visą tekstą]
 The aim of the study was to evaluate the relationship of baseline HVPG and noninvasive parameters of portal hypertension and to assess the efficacy of pharmacological therapy in cirrhotic patients. The objectives of the study 1.To evaluate the relationship of baseline HVPG with clinical, laboratory, endoscopy and ultrasound parameters of portal hypertension. 2.To establish the noninvasive parameters of portal hypertension predicting clinically significant HVPG (>12 mm Hg). 3.To identify the factors predicting the variceal bleeding, which is one of the most serious complications of portal hypertension. 4.To assess and compare the effect of two β-blockers, carvedilol and nebivolol, on HVPG in cirrhotic patients. Conclusions 1.Child’s B, C classes (CTP scoring system) liver cirrhosis, F2, F3 oesophageal varices and history of variceal bleeding are closely related with significant increase of hepatic venous pressure gradient. 2.INR, serum albumin, higher score according to the CTP scoring and MELD systems indicate clinically significant portal hypertension. 3.Decreased superior mesenteric artery pulsatility index, monophasic blood flow in the hepatic veins and patent paraumbilical vein at colour Doppler imaging ultrasound reflects clinically significant portal hypertension. 4.Large (F2-F3) oesophageal varices, hepatic venous pressure gradient of ≥18 mm Hg, larger spleen diameter and low maximal hepatic flow velocity are related with variceal bleeding in cirrhotic patients. 5.... [to full text]
 Advisors/Committee Members: Kupčinskas, Limas (Doctoral dissertation supervisor), Irnius, Algimantas (Doctoral dissertation opponent), Dambrauskas, Žilvinas (Doctoral dissertation opponent), Kiudelis, Mindaugas (Doctoral dissertation committee chair), Kondrackienė, Jūratė (Doctoral dissertation committee member), Stakišaitis, Donatas (Doctoral dissertation committee member), Basevičius, Algidas (Doctoral dissertation committee member), Balčiūnienė, Ligita (Doctoral dissertation committee member).
 Subjects/Keywords: Kepenų venų spaudimo gradientas; Kepenų cirozė; Vartų venos hipertenzija; Hepatic venous pressure gradient; Liver cirrhosis; Portal hypertension
 Silkauskaitė, V. (2010). Kepenų venų spaudimo gradiento reikšmė vartų venos hipertenzijos diagnostikai bei medikamentinio gydymo efektyvumo įvertinimui sergantiems kepenų ciroze . (Doctoral Dissertation). Kaunas University of Medicine. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20100422_102715-83882 ;
 Silkauskaitė, Vilma. “Kepenų venų spaudimo gradiento reikšmė vartų venos hipertenzijos diagnostikai bei medikamentinio gydymo efektyvumo įvertinimui sergantiems kepenų ciroze.” 2010. Doctoral Dissertation, Kaunas University of Medicine. Accessed July 18, 2019. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20100422_102715-83882 ;.
 Silkauskaitė, Vilma. “Kepenų venų spaudimo gradiento reikšmė vartų venos hipertenzijos diagnostikai bei medikamentinio gydymo efektyvumo įvertinimui sergantiems kepenų ciroze.” 2010. Web. 18 Jul 2019.
 Silkauskaitė V. Kepenų venų spaudimo gradiento reikšmė vartų venos hipertenzijos diagnostikai bei medikamentinio gydymo efektyvumo įvertinimui sergantiems kepenų ciroze. [Internet] [Doctoral dissertation]. Kaunas University of Medicine; 2010. [cited 2019 Jul 18]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20100422_102715-83882 ;.
 Silkauskaitė V. Kepenų venų spaudimo gradiento reikšmė vartų venos hipertenzijos diagnostikai bei medikamentinio gydymo efektyvumo įvertinimui sergantiems kepenų ciroze. [Doctoral Dissertation]. Kaunas University of Medicine; 2010. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20100422_102715-83882 ;
 10. Smalinskienė, Alina. Kadmio ir cinko jonų bei purpurinės ežiuolės Echinacea purpurea (L) Moench poveikio pelėms įvertinimas.
 Degree: Dissertation, Biology, 2006, Kaunas University of Medicine
 URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2005~D_20060202_114547-43693 ;
 ► THE ASSESSMENT OF INFLUENCE OF ZINC IONS AND ECHINACEA PURPUREA (L.) MOENCH FOR MICE INTOXICATED BY CADMIUM IONS Abstract Background. Cadmium (Cd), a well-known environmental... (more)
 ▼ THE ASSESSMENT OF INFLUENCE OF ZINC IONS AND ECHINACEA PURPUREA (L.) MOENCH FOR MICE INTOXICATED BY CADMIUM IONS Abstract Background. Cadmium (Cd), a well-known environmental hazard, exerts a number of toxic effects in organism. It disturbs the activity of biochemical systems of cells. Accumulation of cadmium depends on the amount of essential trace elements, including zinc. Echinacea purpurea (L.) Moench (EP) can modify its influence. The aim of the study was to assess the influence of ions of cadmium, zinc, and EP on organism in experimental model of mice. The objectives of the scientific work were as follows: 1. To evaluate the accumulation of cadmium in the internal organs of experimental mice after acute and chronic intraperitoneal and per oral intoxication. 2. To assess morphological changes in liver tissue, mitotic and apoptotic activity of liver cells after the intoxication by cadmium ions of different duration and dose. 3. To assess the effect of zinc ions to the accumulation of cadmium in the internal organs and to the mitotic and apoptotic activity of liver cells in the organism of mice intoxicated by cadmium. 4. To evaluate the effect of EP to accumulation of cadmium in internal organs, mitotic and apoptotic activity of liver cells after the chronic intraperitoneal and per oral intoxication by cadmium ions. The scientific novelty of the study. This work makes our knowledge about mechanisms and outcomes of acute and chronic exposure to cadmium deeper. The... [to full text] Advisors/Committee Members: Pangonytė, Dalia (Doctoral dissertation opponent), Lesauskaitė, Vaiva (Doctoral dissertation advisor), Zabulytė, Danguolė (Doctoral dissertation opponent), Banienė, Rasa (Doctoral dissertation committee member), Aniulienė, Albina (Doctoral dissertation committee member), Abdrachmanovas, Olegas (Doctoral dissertation supervisor), Jankauskas, Rimantas (Doctoral dissertation committee member), Kuras, Antanas (Doctoral dissertation committee member), Ivanovienė, Laima (Doctoral dissertation committee chair).
 Subjects/Keywords: Atominė absorbcinė spektroskopija; Pelės; Echinacea purpurea; Purpurinė ežiuolė; Mitotic and apoptotic index of liver cells; Kepenų ląstelių mitozinis ir apoptozinis indeksas; Cadmium; Kadmis; Cinkas; Atomic absorption spectroscopy; Mice; Zinc
 Smalinskienė, A. (2006). Kadmio ir cinko jonų bei purpurinės ežiuolės Echinacea purpurea (L) Moench poveikio pelėms įvertinimas . (Doctoral Dissertation). Kaunas University of Medicine. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2005~D_20060202_114547-43693 ;
 Smalinskienė, Alina. “Kadmio ir cinko jonų bei purpurinės ežiuolės Echinacea purpurea (L) Moench poveikio pelėms įvertinimas.” 2006. Doctoral Dissertation, Kaunas University of Medicine. Accessed July 18, 2019. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2005~D_20060202_114547-43693 ;.
 Smalinskienė, Alina. “Kadmio ir cinko jonų bei purpurinės ežiuolės Echinacea purpurea (L) Moench poveikio pelėms įvertinimas.” 2006. Web. 18 Jul 2019.
 Smalinskienė A. Kadmio ir cinko jonų bei purpurinės ežiuolės Echinacea purpurea (L) Moench poveikio pelėms įvertinimas. [Internet] [Doctoral dissertation]. Kaunas University of Medicine; 2006. [cited 2019 Jul 18]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2005~D_20060202_114547-43693 ;.
 Smalinskienė A. Kadmio ir cinko jonų bei purpurinės ežiuolės Echinacea purpurea (L) Moench poveikio pelėms įvertinimas. [Doctoral Dissertation]. Kaunas University of Medicine; 2006. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2005~D_20060202_114547-43693 ;