dkoterwa/mlqa_filtered huggingface dataset:
Asthma is clinically classified according to the frequency of symptoms, forced expiratory volume in one second (FEV1), and peak expiratory flow rate. Asthma may also be classified as atopic (extrinsic) or non-atopic (intrinsic), based on whether symptoms are precipitated by allergens (atopic) or not (non-atopic). While asthma is classified based on severity, at the moment there is no clear method for classifying different subgroups of asthma beyond this system. Finding ways to identify subgroups that respond well to different types of treatments is a current critical goal of asthma research.Although asthma is a chronic obstructive condition, it is not considered as a part of chronic obstructive pulmonary disease, as this term refers specifically to combinations of disease that are irreversible such as bronchiectasis and emphysema. Unlike these diseases, the airway obstruction in asthma is usually reversible; however, if left untreated, the chronic inflammation from asthma can lead the lungs to become irreversibly obstructed due to airway remodeling. In contrast to emphysema, asthma affects the bronchi, not the alveoli.

Question: what are the two categories of asthma?
Answer: atopic (extrinsic) or non-atopic (intrinsic)
Asthma was recognized in ancient Egypt and was treated by drinking an incense mixture known as kyphi. It was officially named as a specific respiratory problem by Hippocrates circa 450 BC, with the Greek word for "panting" forming the basis of our modern name. In 200 BC it was believed to be at least partly related to the emotions. In the 12th century the Jewish physician-philosopher Maimonides wrote a treatise on asthma in Arabic, based partly on Arabic sources, in which he discussed the symptoms, proposed various dietary and other means of treatment, and emphasized the importance of climate and clean air.In 1873, one of the first papers in modern medicine on the subject tried to explain the pathophysiology of the disease while one in 1872, concluded that asthma can be cured by rubbing the chest with chloroform liniment. Medical treatment in 1880 included the use of intravenous doses of a drug called pilocarpine. In 1886, F. H. Bosworth theorized a connection between asthma and hay fever. Epinephrine was first referred to in the treatment of asthma in 1905. Oral corticosteroids began to be used for this condition in the 1950s while inhaled corticosteroids and selective short acting beta agonist came into wide use in the 1960s.A notable and well-documented case in the 19th century was that of young Theodore Roosevelt (1858–1919). At that time there was no effective treatment. Roosevelt's youth was in large part shaped by his poor health partly related to his asthma. He experienced recurring nighttime asthma attacks that caused the experience of being smothered to death, terrifying the boy and his parents.During the 1930s to 1950s, asthma was known as one of the "holy seven" psychosomatic illnesses. Its cause was considered to be psychological, with treatment often based on psychoanalysis and other talking cures. As these psychoanalysts interpreted the asthmatic wheeze as the suppressed cry of the child for its mother, they considered the treatment of depression to be especially important for individuals with asthma.

Question: Which medication was used for asthma in the 1960s?
Answer: inhaled corticosteroids

Question: which group of people were given priority for treatment of depression during the 1930s to 1950s
Answer: individuals with asthma
Family history is a risk factor for asthma, with many different genes being implicated. If one identical twin is affected, the probability of the other having the disease is approximately 25%. By the end of 2005, 25 genes had been associated with asthma in six or more separate populations, including GSTM1, IL10, CTLA-4, SPINK5, LTC4S, IL4R and ADAM33, among others. Many of these genes are related to the immune system or modulating inflammation. Even among this list of genes supported by highly replicated studies, results have not been consistent among all populations tested.  In 2006 over 100 genes were associated with asthma in one genetic association study alone; more continue to be found.Some genetic variants may only cause asthma when they are combined with specific environmental exposures. An example is a specific single nucleotide polymorphism in the CD14 region and exposure to endotoxin (a bacterial product). Endotoxin exposure can come from several environmental sources including tobacco smoke, dogs, and farms. Risk for asthma, then, is determined by both a person's genetics and the level of endotoxin exposure.

Question: What do genes associated with causing asthma require?
Answer: specific environmental exposures

Question: How likely is the other twin to be inflicted with the disease if one twin is affected?
Answer: 25%

Question: What has result shown on studies on genes?
Answer: results have not been consistent among all populations tested
Many environmental factors have been associated with asthma's development and exacerbation including allergens, air pollution, and other environmental chemicals. Smoking during pregnancy and after delivery is associated with a greater risk of asthma-like symptoms. Low air quality from factors such as traffic pollution or high ozone levels has been associated with both asthma development and increased asthma severity. Over half of cases in children in the United States occur in areas with air quality below EPA standards. Low air quality is more common in low-income and minority communities.Exposure to indoor volatile organic compounds may be a trigger for asthma; formaldehyde exposure, for example, has a positive association. Also, phthalates in certain types of PVC are associated with asthma in both children and adults. While exposure to pesticides is linked to the development of asthma, a cause and effect relationship has yet to be established.There is an association between acetaminophen (paracetamol) use and asthma. The majority of the evidence does not, however, support a causal role. A 2014 review found that the association disappeared when respiratory infections were taken into account. Use by a mother during pregnancy is also associated with an increased risk as is psychological stress during pregnancy.Asthma is associated with exposure to indoor allergens. Common indoor allergens include dust mites, cockroaches, animal dander (fragments of fur or feathers), and mold. Efforts to decrease dust mites have been found to be ineffective on symptoms in sensitized subjects. Certain viral respiratory infections, such as respiratory syncytial virus and rhinovirus, may increase the risk of developing asthma when acquired as young children. Certain other infections, however, may decrease the risk.

Question: What increases the chances of a child developing asthma?
Answer: viral respiratory infections

Question: What are the some of the causes of asthma development in the current world?
Answer: allergens, air pollution, and other environmental chemicals
Many other conditions can cause symptoms similar to those of asthma. In children, other upper airway diseases such as allergic rhinitis and sinusitis should be considered as well as other causes of airway obstruction including foreign body aspiration, tracheal stenosis, laryngotracheomalacia, vascular rings, enlarged lymph nodes or neck masses. Bronchiolitis and other viral infections may also produce wheezing. In adults, COPD, congestive heart failure, airway masses, as well as drug-induced coughing due to ACE inhibitors should be considered. In both populations vocal cord dysfunction may present similarly.Chronic obstructive pulmonary disease can coexist with asthma and can occur as a complication of chronic asthma.  After the age of 65, most people with obstructive airway disease will have asthma and COPD.  In this setting, COPD can be differentiated by increased airway neutrophils, abnormally increased wall thickness, and increased smooth muscle in the bronchi.  However, this level of investigation is not performed due to COPD and asthma sharing similar principles of management: corticosteroids, long-acting beta-agonists, and smoking cessation. It closely resembles asthma in symptoms, is correlated with more exposure to cigarette smoke, an older age, less symptom reversibility after bronchodilator administration, and decreased likelihood of family history of atopy.

Question: Name one upper airway disease.
Answer: allergic rhinitis
Many people with asthma, like those with other chronic disorders, use alternative treatments; surveys show that roughly 50% use some form of unconventional therapy. There is little data to support the effectiveness of most of these therapies.  Evidence is insufficient to support the usage of vitamin C. There is tentative support for its use in exercise induced bronchospasm. In people with mild to moderate asthma, treatment with vitamin D supplementation is likely to reduce the risk of asthma exacerbations.Acupuncture is not recommended for the treatment as there is insufficient evidence to support its use. Air ionisers show no evidence that they improve asthma symptoms or benefit lung function; this applied equally to positive and negative ion generators.Manual therapies, including osteopathic, chiropractic, physiotherapeutic and respiratory therapeutic maneuvers, have insufficient evidence to support their use in treating asthma.  The Buteyko breathing technique for controlling hyperventilation may result in a reduction in medication use; however, the technique does not have any effect on lung function.  Thus an expert panel felt that evidence was insufficient to support its use.

Question: Why expert could use the evidence?
Answer: insufficient to support its use
Oxygen to alleviate hypoxia if saturations fall below 92%.

Question: What percentage of oxygen is required for alleviation?
Answer: 92%
Some individuals will have stable asthma for weeks or months and then suddenly develop an episode of acute asthma. Different individuals react to various factors in different ways. Most individuals can develop severe exacerbation from a number of triggering agents.Home factors that can lead to exacerbation of asthma include dust, animal dander (especially cat and dog hair), cockroach allergens and mold. Perfumes are a common cause of acute attacks in women and children. Both viral and bacterial infections of the upper respiratory tract can worsen the disease. Psychological stress may worsen symptoms – it is thought that stress alters the immune system and thus increases the airway inflammatory response to allergens and irritants.

Question: What strengthen symptoms ?
Answer: Psychological stress
Spirometry is recommended to aid in diagnosis and management. It is the single best test for asthma. If the FEV1 measured by this technique improves more than 12% and increases by at least 200 milliliters following administration of a bronchodilator such as salbutamol, this is supportive of the diagnosis. It however may be normal in those with a history of mild asthma, not currently acting up. As caffeine is a bronchodilator in people with asthma, the use of caffeine before a lung function test may interfere with the results. Single-breath diffusing capacity can help differentiate asthma from COPD. It is reasonable to perform spirometry every one or two years to follow how well a person's asthma is controlled.

Question: By how many milliliters does the FEV1 has to increase in order for the diagnosis to be positive?
Answer: 200
The methacholine challenge involves the inhalation of increasing concentrations of a substance that causes airway narrowing in those predisposed. If negative it means that a person does not have asthma; if positive, however, it is not specific for the disease.Other supportive evidence includes: a ≥20% difference in peak expiratory flow rate on at least three days in a week for at least two weeks, a ≥20% improvement of peak flow following treatment with either salbutamol, inhaled corticosteroids or prednisone, or a ≥20% decrease in peak flow following exposure to a trigger. Testing peak expiratory flow is more variable than spirometry, however, and thus not recommended for routine diagnosis. It may be useful for daily self-monitoring in those with moderate to severe disease and for checking the effectiveness of new medications. It may also be helpful in guiding treatment in those with acute exacerbations.

Question: what are the uses of peak expiratory flow?
Answer: guiding treatment in those with acute exacerbations
While asthma is a well-recognized condition, there is not one universal agreed upon definition. It is defined by the Global Initiative for Asthma as "a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. The chronic inflammation is associated with airway hyper-responsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness and coughing particularly at night or in the early morning. These episodes are usually associated with widespread but variable airflow obstruction within the lung that is often reversible either spontaneously or with treatment".There is currently no precise test for the diagnosis, which is typically based on the pattern of symptoms and response to therapy over time. A diagnosis of asthma should be suspected if there is a history of recurrent wheezing, coughing or difficulty breathing and these symptoms occur or worsen due to exercise, viral infections, allergens or air pollution. Spirometry is then used to confirm the diagnosis. In children under the age of six the diagnosis is more difficult as they are too young for spirometry.

Question: who has given it a definition?
Answer: the Global Initiative for Asthma
While there is no cure for asthma, symptoms can typically be improved. A specific, customized plan for proactively monitoring and managing symptoms should be created. This plan should include the reduction of exposure to allergens, testing to assess the severity of symptoms, and the usage of medications. The treatment plan should be written down and advise adjustments to treatment according to changes in symptoms.The most effective treatment for asthma is identifying triggers, such as cigarette smoke, pets, or aspirin, and eliminating exposure to them. If trigger avoidance is insufficient, the use of medication is recommended.  Pharmaceutical drugs are selected based on, among other things, the severity of illness and the frequency of symptoms. Specific medications for asthma are broadly classified into fast-acting and long-acting categories.Bronchodilators are recommended for short-term relief of symptoms. In those with occasional attacks, no other medication is needed. If mild persistent disease is present (more than two attacks a week), low-dose inhaled corticosteroids or alternatively, a leukotriene antagonist or a mast cell stabilizer by mouth is recommended. For those who have daily attacks, a higher dose of inhaled corticosteroids is used. In a moderate or severe exacerbation, corticosteroids by mouth are added to these treatments.People with asthma have higher rates of anxiety and depression. This is associated with poorer asthma control. Cognitive behavioral therapy may improve quality of life, asthma control, and anxiety levels in people with asthma.

Question: What can doctors advise people to do to help the discomfort when dealing with asthma?
Answer: reduction of exposure to allergens, testing to assess the severity of symptoms, and the usage of medications

Question: Whats a disease that has no cure?
Answer: asthma

Question: For people who have daily problems use what?
Answer: corticosteroids
Al-Yamamah (Arabic: اليمامة‎, romanized: al-Yamāmah) is an ancient historical region lying to the east of the plateau of Najd in modern-day Saudi Arabia, or sometimes more specifically, the now-extinct ancient village of Jaww Al-Yamamah, near Al-Kharj, after which the rest of the region was named.  Only a handful of centralized states ever arose in Yamamah, but it figured prominently in early Islamic history due to it becoming a central theater in the Ridda Wars immediately following Muhammad's death.  The region was gradually subsumed in recent centuries under the term "Najd", which encompasses a larger area.  However, the term "Al-Yamamah" still lives on as a nostalgic historical term that is invoked to emphasize the region's ties with its ancient past.  The current headquarters of the Saudi government in Riyadh, for example, is known as the Palace of Yamamah.

Question: What ancient historical region Al-Yamamah is located in?
Answer: east of the plateau of Najd in modern-day Saudi Arabia
Located on the Atlantic coast of the Sahara Desert, it lies on the west coast of Africa. With the exception of Friendship Port and a small fishing port, the coastal strip is mostly left empty and allowed to flood. The coastline includes shifting sandbanks and sandy beaches. There are areas of quicksand close to the harbour. Nouakchott is largely flat and only a few meters above sea level. It is threatened by the sand dunes advancing from its eastern side which pose a daily problem. There have been efforts to save particular areas, including work by Jean Meunier. Owing to the rapid build-up, the city is quite spread out, with few tall buildings. Most buildings are one-story.Nouakchott is built around a large tree-lined street, Avenue Gamal Abdel Nasser, which runs northeast through the city centre from the airport. It divides the city into two, with the residential areas in the north and the medina quarter, along with the kebbe, a shanty town formed due to the displacement of people from other areas by the desert. Other major streets are named (in French) for notable Mauritanian or international figures of the 1960s: Avenue Abdel Nasser, Avenue Charles de Gaulle, Avenue Kennedy, and Avenue Lumumba, for example.The kebbe consists of cement buildings that are built overnight and made to look permanent to avoid destruction by the authorities. In 1999, it was estimated that more than half of the city's inhabitants lived in tents and shacks, which were used for residential as well as business purposes. The city is broken into nine arrondissements, sub-divided into alphabetised Îlots. These are Teyarett, Ksar, Tevragh Zeïna, Toujournine, Sebkha, El Mina, Dar Naïm, Arafat and Riad. The Sebkha (Cinquième) Arrondissement is home to a large shopping area.

Question: Where can you mind some shifting sandbanks like Friendship Port?
Answer: west coast of Africa
A variety of resources are available for those wishing to prepare for the GRE. ETS provides preparation software called PowerPrep, which contains two practice tests of retired questions, as well as further practice questions and review material. Since the software replicates both the test format and the questions used, it can be useful to predict the actual GRE scores. ETS does not license their past questions to any other company, making them the only source for official retired material. ETS used to publish the "BIG BOOK" which contained a number of actual GRE questions; however, this publishing was abandoned. Several companies provide courses, books, and other unofficial preparation materials.

Question: What is yielded by the different companies?
Answer: courses, books, and other unofficial preparation materials
In addition to GRE scores, admission to graduate schools depends on several other factors, such as GPA, letters of recommendation, and statements of purpose. Furthermore, unlike other standardized admissions tests (such as the SAT, LSAT, and MCAT), the use and weight of GRE scores vary considerably not only from school to school, but also from department to department and program to program. For instance, most business schools and economics programs require very high GRE or GMAT scores for entry, while engineering programs are known to allow more score variation. Liberal arts programs may only consider the applicant's verbal score, while mathematics and science programs may only consider quantitative ability. Some schools use the GRE in admissions decisions, but not in funding decisions; others use it for selection of scholarship and fellowship candidates, but not for admissions. In some cases, the GRE may be a general requirement for graduate admissions imposed by the university, while particular departments may not consider the scores at all.  Graduate schools will typically provide the average scores of previously admitted students and information about how the GRE is considered in admissions and funding decisions. In some cases programs have hard cut off requirements for the GRE; for example, the Yale Economics PhD program requires a minimum quantitative score of 160 to apply. The best way to ascertain how a particular school or program evaluates a GRE score in the admissions process is to contact the person in charge of graduate admissions for the specific program in question.

Question: What are three admissions tests?
Answer: SAT, LSAT, and MCAT

Question: What is the only score the Liberal arts program can consider?
Answer: verbal score
The GMAT (Graduate Management Admission Test) is a computer-adaptive standardized test in mathematics and the English language for measuring aptitude to succeed academically in graduate business studies.

Question: What is the acronym for the Graduate Management Admission Test?
Answer: GMAT
The analytical writing section consists of two different essays, an "issue task" and an "argument task".  The writing section is graded on a scale of 0–6, in half-point increments. The essays are written on a computer using a word processing program specifically designed by ETS. The program allows only basic computer functions and does not contain a spell-checker or other advanced features. Each essay is scored by at least two readers on a six-point holist scale.  If the two scores are within one point, the average of the scores is taken.  If the two scores differ by more than a point, a third reader examines the response.

Question: What sort of features are not included in the program?
Answer: spell-checker or other advanced features
While the general and subject tests are held at many undergraduate institutions, the computer-based general test is only held at test centers with appropriate technological accommodations. In the United States, students in major cities or from large universities will usually find a nearby test center, while those in more isolated areas may have to travel a few hours to an urban or university location. Many industrialized countries also have test centers, but at times test-takers must cross country borders.

Question: Test centers are readily available to students from what type of university?
Answer: large universities
"Six Sigma" was registered June 11, 1991 as U.S. Service Mark 1,647,704. In 2005 Motorola attributed over US$17 billion in savings to Six Sigma.Other early adopters of Six Sigma include Honeywell and General Electric, where Jack Welch introduced the method. By the late 1990s, about two-thirds of the Fortune 500 organizations had begun Six Sigma initiatives with the aim of reducing costs and improving quality.In recent years, some practitioners have combined Six Sigma ideas with lean manufacturing to create a methodology named Lean Six Sigma. The Lean Six Sigma methodology views lean manufacturing, which addresses process flow and waste issues, and Six Sigma, with its focus on variation and design, as complementary disciplines aimed at promoting "business and operational excellence".In 2011, the International Organization for Standardization (ISO) has published the first standard "ISO 13053:2011" defining a Six Sigma process. Other standards have been created mostly by universities or companies that have first-party certification programs for Six Sigma.

Question: How much savings was attributed to Six Sigma?
Answer: 17 billion