dkoterwa/mlqa_filtered huggingface dataset:
South Korea hosted the Asian Games in 1986 (Seoul), 2002 (Busan) and 2014 (Incheon). It also hosted the Winter Universiade in 1997, the Asian Winter Games in 1999 and the Summer Universiade in 2003, 2015. In 1988, South Korea hosted the Summer Olympics in Seoul, coming fourth with 12 gold medals, 10 silver medals and 11 bronze medals. South Korea regularly performs well in archery, shooting, table tennis, badminton, short track speed skating, handball, hockey, freestyle wrestling, Greco-Roman wrestling, baseball, judo, taekwondo, speed skating, figure Skating, and weightlifting. The Seoul Olympic Museum is a museum in Seoul, South Korea, dedicated to the 1988 Summer Olympics. On July 6, 2011 Pyeongchang was chosen by the IOC to host the 2018 Winter Olympics.

Question: What year did South Korea host the Olympics?
Answer: 1988
South Korea occupies the southern portion of the Korean Peninsula, which extends some 1,100 km (680 mi) from the Asian mainland. This mountainous peninsula is flanked by the Yellow Sea to the west, and the Sea of Japan to the east. Its southern tip lies on the Korea Strait and the East China Sea.

Question: What flanks the mountainous peninsula on the west?
Answer: Yellow Sea

Question: Which kind of land mass is it?
Answer: Peninsula
South Korea shares its traditional culture with North Korea, but the two Koreas have developed distinct contemporary forms of culture since the peninsula was divided in 1945. Historically, while the culture of Korea has been heavily influenced by that of neighboring China, it has nevertheless managed to develop a unique cultural identity that is distinct from its larger neighbor. Its rich and vibrant culture left 19 UNESCO Intangible Cultural Heritages of Humanity, the third largest in the world, along with 12 World Heritage Sites. The South Korean Ministry of Culture, Sports and Tourism actively encourages the traditional arts, as well as modern forms, through funding and education programs.The industrialization and urbanization of South Korea have brought many changes to the way modern Koreans live. Changing economics and lifestyles have led to a concentration of population in major cities, especially the capital Seoul, with multi-generational households separating into nuclear family living arrangements. A 2014 Euromonitor study found that South Koreans drink the most alcohol on a weekly basis compared to the rest of the world. South Koreans drink 13.7 shots of liquor per week on average and, of the 44 other countries analyzed, Russia, the Philippines, and Thailand follow.

Question: Which year was the peninsula divided?
Answer: 1945
The country, including all its islands, lies between latitudes 33° and 39°N, and longitudes 124° and 130°E. Its total area is 100,032 square kilometers (38,622.57 sq mi).South Korea can be divided into four general regions: an eastern region of high mountain ranges and narrow coastal plains; a western region of broad coastal plains, river basins, and rolling hills; a southwestern region of mountains and valleys; and a southeastern region dominated by the broad basin of the Nakdong River.South Korea's terrain is mostly mountainous, most of which is not arable. Lowlands, located primarily in the west and southeast, make up only 30% of the total land area.

Question: How much land area does the lowlands make up?
Answer: 30%
The martial art taekwondo originated in Korea. In the 1950s and 1960s, modern rules were standardized, with taekwondo becoming an official Olympic sport in 2000. Other Korean martial arts include Taekkyon, hapkido, Tang Soo Do, Kuk Sool Won, kumdo and subak.Football and baseball have traditionally been regarded as the most popular sports in Korea. Recent polling indicates that a majority, 41% of South Korean sports fans continue to self-identify as football fans, with baseball ranked 2nd at 25% of respondents. However, the polling did not indicate the extent to which respondents follow both sports. The national football team became the first team in the Asian Football Confederation to reach the FIFA World Cup semi-finals in the 2002 FIFA World Cup, jointly hosted by South Korea and Japan. The Korea Republic national team (as it is known) has qualified for every World Cup since Mexico 1986, and has broken out of the group stage twice: first in 2002, and again in 2010, when it was defeated by eventual semi-finalist Uruguay in the Round of 16. At the 2012 Summer Olympics, South Korea won the Bronze Medal for football.

Question: Where was taekwondo originally from?
Answer: Korea
A chronic cough is often the first symptom to develop. Early on it may just occur occasionally or may not result in sputum. When a cough persists for more than three months each year for at least two years, in combination with sputum production and without another explanation, it is by definition chronic bronchitis. Chronic bronchitis can occur before the restricted airflow and thus COPD fully develops. The amount of sputum produced can change over hours to days. In some cases, the cough may not be present or may only occur occasionally and may not be productive. Some people with COPD attribute the symptoms to a "smoker's cough". Sputum may be swallowed or spat out, depending often on social and cultural factors. Vigorous coughing may lead to rib fractures or a brief loss of consciousness. Those with COPD often have a history of "common colds" that last a long time.

Question: What may occur in some cases of Chronic Bronchitis?
Answer: cough may not be present or may only occur occasionally

Question: What factors determine whether sputum is swallowed or spit out?
Answer: social and cultural
An acute exacerbation of COPD is defined as increased shortness of breath, increased sputum production, a change in the color of the sputum from clear to green or yellow, or an increase in cough in someone with COPD. They may present with signs of increased work of breathing such as fast breathing, a fast heart rate, sweating, active use of muscles in the neck, a bluish tinge to the skin, and confusion or combative behavior in very severe exacerbations. Crackles may also be heard over the lungs on examination with a stethoscope.

Question: where are the crackles heard?
Answer: over the lungs
Chronic obstructive pulmonary disease (COPD) is a type of obstructive lung disease characterized by long-term breathing problems and poor airflow. The main symptoms include shortness of breath and cough with sputum production. COPD is a progressive disease, meaning it typically worsens over time. Eventually, everyday activities such as walking or getting dressed become difficult. Chronic bronchitis and emphysema are older terms used for different types of COPD. The term "chronic bronchitis" is still used to define a productive cough that is present for at least three months each year for two years. Those with such a cough are at a greater risk of developing COPD. The term "emphysema" is also used for the abnormal presence of air or other gas within tissues.Tobacco smoking is the most common cause of COPD, with factors such as air pollution and genetics playing a smaller role. In the developing world, one of the common sources of air pollution is poorly vented heating and cooking fires. Long-term exposure to these irritants causes an inflammatory response in the lungs, resulting in narrowing of the small airways and breakdown of lung tissue. The diagnosis is based on poor airflow as measured by lung function tests. In contrast to asthma, the airflow reduction does not improve much with the use of a bronchodilator.Most cases of COPD can be prevented by reducing exposure to risk factors. This includes decreasing rates of smoking and improving indoor and outdoor air quality. While treatment can slow worsening, no cure is known. COPD treatments include smoking cessation, vaccinations, respiratory rehabilitation, and often inhaled bronchodilators and steroids. Some people may benefit from long-term oxygen therapy or lung transplantation. In those who have periods of acute worsening, increased use of medications and hospitalization may be needed.As of 2015, COPD affected about 174.5 million (2.4%) of the global population. It typically occurs in people over the age of 40. Males and females are affected equally commonly. In 2015, it resulted in 3.2 million deaths, up from 2.4 million deaths in 1990. More than 90% of these deaths occur in the developing world. The number of deaths is projected to increase further because of higher smoking rates in the developing world, and an aging population in many countries. It resulted in an estimated economic cost of $2.1 trillion in 2010.

Question: Diagnosis of poor airflow included decreasing rates of smoking and what?
Answer: improving indoor and outdoor air quality
Globally, as of 2010, COPD affected approximately 329 million people (4.8% of the population). The disease affects men and women almost equally, as there has been increased tobacco use among women in the developed world. The increase in the developing world between 1970 and the 2000s is believed to be related to increasing rates of smoking in this region, an increasing population and an aging population due to fewer deaths from other causes such as infectious diseases. Some developed countries have seen increased rates, some have remained stable and some have seen a decrease in COPD prevalence. The global numbers are expected to continue increasing as risk factors remain common and the population continues to get older.Between 1990 and 2010 the number of deaths from COPD decreased slightly from 3.1 million to 2.9 million and became the fourth leading cause of death. In 2012 it became the third leading cause as the number of deaths rose again to 3.1 million. In some countries, mortality has decreased in men but increased in women. This is most likely due to rates of smoking in women and men becoming more similar. COPD is more common in older people; it affects 34–200 out of 1000 people older than 65 years, depending on the population under review.In England, an estimated 0.84 million people (of 50 million) have a diagnosis of COPD; this translates into approximately one person in 59 receiving a diagnosis of COPD at some point in their lives. In the most socioeconomically deprived parts of the country, one in 32 people were diagnosed with COPD, compared with one in 98 in the most affluent areas. In the United States approximately 6.3% of the adult population, totaling approximately 15 million people, have been diagnosed with COPD. 25 million people may have COPD if currently undiagnosed cases are included. In 2011, there were approximately 730,000 hospitalizations in the United States for COPD. In the United States, COPD is estimated to be the third leading cause of death in 2011.

Question: how has mortality changed between men and women in some countries?
Answer: mortality has decreased in men but increased in women

Question: How many people in the US have COPD?
Answer: 15 million
Intense and prolonged exposure to workplace dusts, chemicals, and fumes increases the risk of COPD in both smokers and nonsmokers. Workplace exposure is believed to be the cause in 10–20% of cases. In the United States, it is believed that it is related to more than 30% of cases among those who have never smoked and probably represents a greater risk in countries without sufficient regulations.A number of industries and sources have been implicated, including high levels of dust in coal mining, gold mining, and the cotton textile industry, occupations involving cadmium and isocyanates, and fumes from welding. Working in agriculture is also a risk. In some professions, the risks have been estimated as equivalent to that of one-half to two packs of cigarettes a day. Silica dust and fiberglass dust exposure can also lead to COPD, with the risk unrelated to that for silicosis. The negative effects of dust exposure and cigarette smoke exposure appear to be additive or possibly more than additive.

Question: 10-20% of COPD cases come from where?
Answer: Workplace exposure
The most common symptoms of COPD are sputum production, shortness of breath, and a productive cough. These symptoms are present for a prolonged period of time and typically worsen over time. It is unclear whether different types of COPD exist. While previously divided into emphysema and chronic bronchitis, emphysema is only a description of lung changes rather than a disease itself, and chronic bronchitis is simply a descriptor of symptoms that may or may not occur with COPD.

Question: What disease are professionals unclear if multiple iterations of exist?
Answer: COPD
The primary risk factor for COPD globally is tobacco smoking. Of those who smoke, about 20% will get COPD, and of those who are lifelong smokers, about half will get COPD. In the United States and United Kingdom, of those with COPD, 80–95% are either current or previous smokers. The likelihood of developing COPD increases with the total smoke exposure. Additionally, women are more susceptible to the harmful effects of smoke than men. In non-smokers, exposure to second-hand smoke is the cause in up to 20% of cases. Other types of smoke, such as, marijuana, cigar, and water-pipe smoke, also confer a risk. Water-pipe smoke appears to be as harmful as smoking cigarettes. Problems from marijuana smoke may only be with heavy use. Women who smoke during pregnancy may increase the risk of COPD in their child. For the same amount of cigarette smoking, women have a higher risk of COPD than men.

Question: What percentage of people with COPD are current or former smokers (in the US and UK)?
Answer: 80–95%
As of 2005, recombinant growth hormones available in the United States (and their manufacturers) included Nutropin (Genentech), Humatrope (Lilly), Genotropin (Pfizer), Norditropin (Novo),  and Saizen (Merck Serono). In 2006, the U.S. Food and Drug Administration (FDA) approved a version of rHGH called Omnitrope (Sandoz).  A sustained-release form of growth hormone, Nutropin Depot (Genentech and Alkermes) was approved by the FDA in 1999, allowing for fewer injections (every 2 or 4 weeks instead of daily); however, the product was discontinued by Genentech/Alkermes in 2004 for financial reasons (Nutropin Depot required significantly more resources to produce than the rest of the Nutropin line).

Question: What company manufactured the first FDA approved rHGH?
Answer: Sandoz
GH also stimulates, through the JAK-STAT signaling pathway, the production of insulin-like growth factor 1 (IGF-1, formerly known as somatomedin C), a hormone homologous to proinsulin. The liver is a major target organ of GH for this process and is the principal site of IGF-1 production. IGF-1 has growth-stimulating effects on a wide variety of tissues. Additional IGF-1 is generated within target tissues, making it what appears to be both an endocrine and an autocrine/paracrine hormone. IGF-1 also has stimulatory effects on osteoblast and chondrocyte activity to promote bone growth.In addition to increasing height in children and adolescents, growth hormone has many other effects on the body:

Question: What has a simulatory effect?
Answer: IGF-1
In the United States, it is legal to give a bovine GH to dairy cows to increase milk production, and is legal to use GH in raising cows for beef; see article on Bovine somatotropin, cattle feeding, dairy farming and the beef hormone controversy.

Question: What substance encourages milk in bovine cows?
Answer: bovine GH
Increased height during childhood is the most widely known effect of GH.  Height appears to be stimulated by at least two mechanisms:

Question: Growth hormone causes what to happen in childhood?
Answer: Increased height
Increases calcium retention, and strengthens and increases the mineralization of bone

Question: What kind of retention is increased?
Answer: calcium
Prolonged GH excess thickens the bones of the jaw, fingers and toes, resulting heaviness of the jaw and increased size of digits, referred to as acromegaly. Accompanying problems can include sweating, pressure on nerves (e.g. carpal tunnel syndrome), muscle weakness, excess sex hormone-binding globulin (SHBG), insulin resistance or even a rare form of type 2 diabetes, and reduced sexual function.

Question: What is an example of a condition where there is pressure on the nerves?
Answer: carpal tunnel syndrome
The major isoform of the human growth hormone is a protein of 191 amino acids and a molecular weight of 22,124 daltons. The structure includes four helices necessary for functional interaction with the GH receptor. It appears that, in structure, GH is evolutionarily homologous to prolactin and chorionic somatomammotropin. Despite marked structural similarities between growth hormone from different species, only human and Old World monkey growth hormones have significant effects on the human growth hormone receptor.Several molecular isoforms of GH exist in the pituitary gland and are released to blood. In particular, a variant of approximately 20 kDa originated by an alternative splicing is present in a rather constant 1:9 ratio, while recently an additional variant of ~ 23-24 kDa has also been reported in post-exercise states at higher proportions. This variant has not been identified, but it has been suggested to coincide with a 22 kDa glycosylated variant of 23 kDa identified in the pituitary gland. Furthermore, these variants circulate partially bound to a protein (growth hormone-binding protein, GHBP), which is the truncated part of the growth hormone receptor, and an acid-labile subunit (ALS).

Question: Which hormone is also found in the pituitary gland?
Answer: GH
These cells release the peptides Growth hormone-releasing hormone (GHRH or somatocrinin) and Growth hormone-inhibiting hormone (GHIH or somatostatin) into the hypophyseal portal venous blood surrounding the pituitary.

Question: What is another name for the hormone-inhibiting hormone?
Answer: somatostatin
To capitalize on the idea that GH might be useful to combat aging, companies selling dietary supplements have websites selling products linked to GH in the advertising text, with medical-sounding names described as "HGH Releasers". Typical ingredients include amino acids, minerals, vitamins, and/or herbal extracts, the combination of which are described as causing the body to make more GH with corresponding beneficial effects. In the United States, because these products are marketed as dietary supplements it is illegal for them to contain GH, which is a drug. Also, under United States law, products sold as dietary supplements cannot have claims that the supplement treats or prevents any disease or condition, and the advertising material must contain a statement that the health claims are not approved by the FDA. The FTC and the FDA do enforce the law when they become aware of violations.

Question: What is required in ad campaigns for items that purport to be dietary supplements?
Answer: must contain a statement that the health claims are not approved by the FDA
Treatment with exogenous GH is indicated only in limited circumstances, and needs regular monitoring due to the frequency and severity of side-effects. GH is used as replacement therapy in adults with GH deficiency of either childhood-onset or adult-onset (usually as a result of an acquired pituitary tumor). In these patients, benefits have variably included reduced fat mass, increased lean mass, increased bone density, improved lipid profile, reduced cardiovascular risk factors, and improved psychosocial well-being.

Question: What treatment can cause severe side-effects?
Answer: Treatment with exogenous GH
sex hormonesincreased androgen secretion during puberty (in males from testes and in females from adrenal cortex)

Question: what happens when sex hormones increase during puberty?
Answer: androgen secretion
According to Chinese legend, the Chinese emperor Shennong, reputed to have reigned in about 3000 BCE, inadvertently discovered tea when he noted that when certain leaves fell into boiling water, a fragrant and restorative drink resulted. Shennong is also mentioned in Lu Yu's Cha Jing, a famous early work on the subject of tea.The earliest credible evidence of either coffee drinking or knowledge of the coffee plant appears in the middle of the fifteenth century, in the Sufi monasteries of the Yemen in southern Arabia. From Mocha, coffee spread to Egypt and North Africa, and by the 16th century, it had reached the rest of the Middle East, Persia and Turkey.  From the Middle East, coffee drinking spread to Italy, then to the rest of Europe, and coffee plants were transported by the Dutch to the East Indies and to the Americas.Kola nut use appears to have ancient origins. It is chewed in many West African cultures, in both private and social settings, to restore vitality and ease hunger pangs.

Question: Which amongst the Three Sovereigns in China discovered tea about 5000 years ago?
Answer: Shennong
Caffeine from coffee or other beverages is absorbed by the small intestine within 45 minutes of ingestion and distributed throughout all bodily tissues. Peak blood concentration is reached within 1–2 hours. It is eliminated by first-order kinetics. Caffeine can also be absorbed rectally, evidenced by suppositories of ergotamine tartrate and caffeine (for the relief of migraine) and chlorobutanol and caffeine (for the treatment of hyperemesis). However, rectal absorption is less efficient than oral:  the maximum concentration (Cmax) and total amount absorbed (AUC) are both about 30% (i.e., 1/3.5) of the oral amounts.Caffeine's biological half-life – the time required for the body to eliminate one-half of a dose – varies widely among individuals according to factors such as pregnancy, other drugs, liver enzyme function level (needed for caffeine metabolism) and age. In healthy adults, caffeine's half-life is between 3–7 hours. Smoking decreases the half-life by 30–50%, while oral contraceptives can double it and pregnancy can raise it to as much as 15 hours during the third trimester. In newborns the half-life can be 80 hours or more, dropping very rapidly with age, possibly to less than the adult value by age 6 months. The antidepressant fluvoxamine (Luvox) reduces the clearance of caffeine by more than 90%, and increases its elimination half-life more than tenfold; from 4.9 hours to 56 hours.Caffeine is metabolized in the liver by the cytochrome P450 oxidase enzyme system, in particular, by the CYP1A2 isozyme, into three dimethylxanthines, each of which has its own effects on the body:

Question: how long does caffeine last in a adults body?
Answer: between 3–7 hours
Caffeine is a central nervous system stimulant that reduces fatigue and drowsiness. At normal doses, caffeine has variable effects on learning and memory, but it generally improves reaction time, wakefulness, concentration, and motor coordination. The amount of caffeine needed to produce these effects varies from person to person, depending on body size and degree of tolerance. The desired effects arise approximately one hour after consumption, and the desired effects of a moderate dose usually subside after about three or four hours.Caffeine can delay or prevent sleep and improves task performance during sleep deprivation. Shift workers who use caffeine make fewer mistakes due to drowsiness.A systematic review and meta-analysis from 2014 found that concurrent caffeine and L-theanine use has synergistic psychoactive effects that promote alertness, attention, and task switching; these effects are most pronounced during the first hour post-dose.

Question: What does the dosage of caffeine needed to produce a certain affect depend on?
Answer: body size and degree of tolerance