NFL 2025 season, Week 16 (REG): SF at IND
Date: Monday, 2025-12-22 at 20:15
Stadium: Lucas Oil Stadium (roof: closed, surface: fieldturf)
Final score: SF 48, IND 27
Starting quarterbacks: Brock Purdy (SF) vs Philip Rivers (IND)
Head coaches: Kyle Shanahan (SF) vs Shane Steichen (IND)
Referee: Ron Torbert
Betting lines: spread -4.5, over/under 46.5, moneylines SF -225 / IND 185
Rest days: SF 8, IND 8