A role for c-Myc in the hypoxic induction of VEGF was demonstrated by site-directed mutagenesis of the VEGF promoter and silencing of c-Myc by small interfering RNA.
these findings suggest an alternative mechanism for the hypoxic induction of vegf in colon cancer that does not depend upon hif-1alpha but instead requires the activation of pi3k/rho/rock and c-myc.