These molecules are DNA-binding proteins driving together with ß-catenin the transcription of multiple target genes such as c-myc, cyclin D1, MMP-7, laminin-5Á2 implicated in proliferation, cell-cell attachment, and invasion (13-15).
Aberrant Wnt-signalling and nuclear ß-catenin accumulation may serve as the underlying basis for invasion, metastasis and poor prognosis (8,15).