Given its ability to complement the susceptibility phenotype of its S. cerevisiae homolog, ScAqr1, CgAqr1 was proposed to play a similar role in mediating the extrusion of chemical compounds.
The expression of this gene was found to reduce the intracellular accumulation of (3) H-flucytosine and, to a moderate extent, of (3) H-clotrimazole, consistent with a direct role in antifungal drug efflux.