Nonetheless, our results from both BMVEC and HEK293 suggest that the effects of inhibiting GSK3β should prove universal in the reduction of occludin and claudin-5 protein turnover.
Failor and colleagues used mammary epithelial tumor cells to show that the degradation of GSK3β by glucocorticoid stimulation induces β-catenin membrane localization which then increases transepithelial resistance [34].