Pdr5p is one of the best characterized yeast ABC transporters, conferring resistance to a very broad range of amphiphilic substrates (Kolaczkowski , 1996).
Pdr5p and mammalian ABC P-glycoproteins (P-gp), implicated in MDR phenotypes of tumour cells towards anticancer drugs, are functional homologues sharing numerous drug substrates (Wolfger , 2001).