the most significant changes were found in the cerebellum, where there were decreased numbers of purkinje cells, increased numbers of glial cells, scattered vacuoles and occasional swollen axons.
Sufu as well as Gli1 and Gli2 expression was upregulated in the medulloblastomas compared to adult cerebellum in Ptch1 (+/-) and Sufu (+/-) Ptch1 (+/-) mice.