Collectively, these data reveal a stress-responsive corticosterone-LMO4-PTP1B-mGluR5 cascade that impairs amygdalar eCB signaling and contributes to the development of anxiety.
Our preclinical studies in mice demonstrate the efficacy of using a PTP1B-selective inhibitor, Trodusquemine, a natural Squalamine compound isolated from dogfish liver, to treat anxiety and metabolic syndrome.