further studies have established mecp2 as a multi- functional nuclear protein with roles in chromatin architecture, regulation of rna splicing, and tran- scriptional activation (hite et al , 2009).
These studies show a complex role for MeCP2 in brain function and synaptic plasticity; as such, MeCP2 is associated with epigenetic regulation of the nervous system (MacDonald and Roskams , 2009).