Similarly, H3K27me3 was found at the miR-200b-200a-429 promoter but not the miR-200c-141 promoter in Hs578T cells (data not shown).
These results indicate that repression of miR-200b-200a-429 and miR-200c-141 genes is mediated by distinct cell context-dependent epigenetic mechanisms involving specific and dual combinations of histone and DNA methyltransferases.