title: Quaternary research in New Zealand and relationship to the International Union for Quaternary Research (INQUA). Annual Report for the Catalyst Fund: Influence 2017 (with Appendix).

authors: Lowe, David J.

abstract: It is anticipated that this report has been discussed in some form with the national committee or organisation identified above and provides the wider view of this network.
I have discussed the report with some of the leading New Zealand Quaternarists and/or leaders of several INQUAfunded projects/IFGs (names are listed on p. 7). I attach a 17-page document (Appendix A) that summarises Quaternary-related research in New Zealand and the relationship of research to the International Union for Quaternary Research (INQUA) and the associated focus groups and projects. It is referred to in the report below.

text: Quaternary research in New Zealand and relationship to the International Union for Quaternary Research (INQUA). Annual Report for the Catalyst Fund: Influence 2017 (with Appendix). It is anticipated that this report has been discussed in some form with the national committee or organisation identified above and provides the wider view of this network.
I have discussed the report with some of the leading New Zealand Quaternarists and/or leaders of several INQUAfunded projects/IFGs (names are listed on p. 7). I attach a 17-page document (Appendix A) that summarises Quaternary-related research in New Zealand and the relationship of research to the International Union for Quaternary Research (INQUA) and the associated focus groups and projects. It is referred to in the report below.

year: 2018

title: The role of connexin36 gap junctions in modulating the hypnotic effects of isoflurane and propofol in mice

authors: Jacobson, Gregory M.

subjects: Connexin36

abstract: Gap junction blockade is a possible mechanism by which general anaesthetic drugs cause unconsciousness. We measured the sensitivity of connexin36 knockout mice to the hypnotic effects of isoflurane and propofol. The experimental endpoint was recovery of the righting reflex of the anaesthetised animals during 0.2% step-reductions in isoflurane concentration, or following intraperitoneal injection of propofol (100 mg.kg⁻¹). Connexin36 knockout animals were more sensitive to the hypnotic effects of isoflurane than ‘normal’ wild-type animals. The half maximal effective concentration (EC50) for recovery of righting reflex was 0.37% for connexin36 knockout vs 0.49% for wild-type animals (p < 0.001). For propofol, connnexin36 knockout animals showed more rapid loss of righting reflex than wild-type animals (mean (SD) 2.8 (0.13) vs 3.8 (0.27) min); and young (< 60 days) connexin36 knockout animals remained anaesthetised for longer than young wild-type mice (47.2 (2.9) vs 30.5 (1.7) min; p < 0.00001). These findings suggest that the hypnotic effects of anaesthetic drugs may be moderately enhanced by gap junction blockade.

text: The role of connexin36 gap junctions in modulating the hypnotic effects of isoflurane and propofol in mice Gap junction blockade is a possible mechanism by which general anaesthetic drugs cause unconsciousness. We measured the sensitivity of connexin36 knockout mice to the hypnotic effects of isoflurane and propofol. The experimental endpoint was recovery of the righting reflex of the anaesthetised animals during 0.2% step-reductions in isoflurane concentration, or following intraperitoneal injection of propofol (100 mg.kg⁻¹). Connexin36 knockout animals were more sensitive to the hypnotic effects of isoflurane than ‘normal’ wild-type animals. The half maximal effective concentration (EC50) for recovery of righting reflex was 0.37% for connexin36 knockout vs 0.49% for wild-type animals (p < 0.001). For propofol, connnexin36 knockout animals showed more rapid loss of righting reflex than wild-type animals (mean (SD) 2.8 (0.13) vs 3.8 (0.27) min); and young (< 60 days) connexin36 knockout animals remained anaesthetised for longer than young wild-type mice (47.2 (2.9) vs 30.5 (1.7) min; p < 0.00001). These findings suggest that the hypnotic effects of anaesthetic drugs may be moderately enhanced by gap junction blockade.

year: 2011

title: The concept of partnership and The Treaty of Waitangi: Three case studies

authors: Morrison, Sandy

subjects: Te Tiriti o Waitangi

abstract: There has been, and continues to be, considerable debate about the meaning and intent of different versions of the Treaty of Waitangi and about the extent of its relevance to contemporary New Zealand. It is in this context that a number of organisations and institutions in New Zealand, anxious to demonstrate their positive support for the creation of a just society, have attempted to restructure in ways that allow for a 'partnership' between Māori and Pākehā. With reference to three different case studies, I argue here that such restructuring, although generally very well intentioned and very welcome, should not be seen - as it frequently is - as an expression of the fulfilment of partnership obligations arising out of the Treaty of Waitangi. To treat organisational restructuring in this way, particularly where it does not provide both 'partners' with an equal right to determine the operational parameters and future direction of the organisation, is to misrepresent (often wholly unintentionally) the nature of the Treaty. Nevertheless, one way of resolving some of the debates concerning the meaning and intent of the Treaty of Waitangi might be to establish a principle of equal partnership in the governance and management of state institutions.

text: The concept of partnership and The Treaty of Waitangi: Three case studies There has been, and continues to be, considerable debate about the meaning and intent of different versions of the Treaty of Waitangi and about the extent of its relevance to contemporary New Zealand. It is in this context that a number of organisations and institutions in New Zealand, anxious to demonstrate their positive support for the creation of a just society, have attempted to restructure in ways that allow for a 'partnership' between Māori and Pākehā. With reference to three different case studies, I argue here that such restructuring, although generally very well intentioned and very welcome, should not be seen - as it frequently is - as an expression of the fulfilment of partnership obligations arising out of the Treaty of Waitangi. To treat organisational restructuring in this way, particularly where it does not provide both 'partners' with an equal right to determine the operational parameters and future direction of the organisation, is to misrepresent (often wholly unintentionally) the nature of the Treaty. Nevertheless, one way of resolving some of the debates concerning the meaning and intent of the Treaty of Waitangi might be to establish a principle of equal partnership in the governance and management of state institutions.

year: 2005