title: A novel way to quantify schizophrenia symptoms in clinical trials

authors: Medvedev, Oleg N.

subjects: Clinical Trial

abstract: BACKGROUND: A major problem in quantifying symptoms of schizophrenia is establishing a reliable distinction between enduring and dynamic aspects of psychopathology. This is critical for accurate diagnosis, monitoring and evaluating treatment effects in both clinical practice and trials. 
MATERIALS AND METHODS: We applied Generalisability Theory, a robust novel method to distinguish between dynamic and stable aspects of schizophrenia symptoms in the widely used Positive and Negative Symptom Scale (PANSS) using a longitudinal measurement design. The sample included 107 patients with chronic schizophrenia assessed using the PANSS at five time points over a 24-week period during a multi-site clinical trial of N-Acetylcysteine as an add-on to maintenance medication for the treatment of chronic schizophrenia. 
RESULTS: The original PANSS and its three subscales demonstrated good reliability and generalisability of scores (G=0.77-0.93) across sample population and occasions making them suitable for assessment of psychosis risks and long-lasting change following a treatment, while subscales of the five factor models appeared less reliable. The most enduring symptoms represented by the PANSS were poor attention, delusions, blunted affect, and poor rapport. More dynamic symptoms with 40-50% of variance explained by patient transient state including grandiosity, preoccupation, somatic concerns, guilt feeling and hallucinatory behaviour. 
CONCLUSIONS: Identified dynamic symptoms are more amendable to change and should be the primary target of interventions aiming at effectively treating schizophrenia. Separating out the dynamic symptoms would increase assay sensitivity in trials, reduce the signal to noise ratio and increase the potential to detect the effects of novel therapies in clinical trials.

text: A novel way to quantify schizophrenia symptoms in clinical trials BACKGROUND: A major problem in quantifying symptoms of schizophrenia is establishing a reliable distinction between enduring and dynamic aspects of psychopathology. This is critical for accurate diagnosis, monitoring and evaluating treatment effects in both clinical practice and trials. 
MATERIALS AND METHODS: We applied Generalisability Theory, a robust novel method to distinguish between dynamic and stable aspects of schizophrenia symptoms in the widely used Positive and Negative Symptom Scale (PANSS) using a longitudinal measurement design. The sample included 107 patients with chronic schizophrenia assessed using the PANSS at five time points over a 24-week period during a multi-site clinical trial of N-Acetylcysteine as an add-on to maintenance medication for the treatment of chronic schizophrenia. 
RESULTS: The original PANSS and its three subscales demonstrated good reliability and generalisability of scores (G=0.77-0.93) across sample population and occasions making them suitable for assessment of psychosis risks and long-lasting change following a treatment, while subscales of the five factor models appeared less reliable. The most enduring symptoms represented by the PANSS were poor attention, delusions, blunted affect, and poor rapport. More dynamic symptoms with 40-50% of variance explained by patient transient state including grandiosity, preoccupation, somatic concerns, guilt feeling and hallucinatory behaviour. 
CONCLUSIONS: Identified dynamic symptoms are more amendable to change and should be the primary target of interventions aiming at effectively treating schizophrenia. Separating out the dynamic symptoms would increase assay sensitivity in trials, reduce the signal to noise ratio and increase the potential to detect the effects of novel therapies in clinical trials.

year: 2020

title: Meaningful Witnessing in the United States, India & New Zealand: The Possibility Space for Digital Video Within Human Rights, Protest Movements and Activist Practices

authors: Lenzner, Benjamin

subjects: digital video

abstract: This dissertation examines the emergence of digital video practices rooted in human rights, social justice issues and protest movements through a number of select case studies in the United States, India and New Zealand. This project analyzes and critiques the formation of digital video practices through the lens of Manuel DeLanda’s interpretation of assemblage theory. Examining interactions between crucial elements present in a possibility space that aid in the cultivation and assembling of budding forms of digital video, this study considers the implications in the relationships between both material and expressive qualities of these assemblings. The central argument of this thesis asserts that digital video practices centered on human rights, social justice and protest movements require adaptable linkages between supportive structures, creative capacities and digital video technologies in order to produce sustainable and creative digital video practices buttressed by documentary agendas that fuel their dynamic evolution.

My research seeks to engage with the complexities of agency and technology and examines their significance in different contexts by providing a constructive outlet for practitioners to share the process behind their methods in order to offer insight into their creative workflow. Digital video technologies are proliferating at a rapid pace, yet very few video practices have formed that suggest linkages to documentary traditions. One can bear witness, yet to traverse video documentation in order to create a rhetorical argument of meaningful witnessing is a complex process that requires more than easy access to mobile video tools connected to the Internet. The case studies analyzed in these three democratic nations support the argument threaded throughout the project; digital video practices have the potential to thrive, albeit in pockets where formal or informal support systems are present and through assemblages where digital video technologies are constantly being adapted and an investment in human capital is paramount to the privileging of digital video tools or online platforms. Case studies that focus on individual practices in New York City and New Zealand reinforce the difficulties practitioners face when attempting to cultivate video practices without supportive structures. Comparatively with other case studies in India and New York, individual practices with long-term organizational support navigate challenges and re-assemble their practices in order to remain sustainable and influential.

This study also engages with assemblage theory in the context of documentary history and contemporary digital video practices and reassesses the historic relationship between emerging photographic, film and video tools and the lens based practitioners that harness these apparatuses for documentary purposes. Like assemblings themselves, these creative associations are never smooth at their inception, but require adaptable solutions and adjustable reassemblings in order to maintain the potential for sustainable practices to develop and flourish. This dissertation argues that as digital video practices continue to evolve, they have the potential to redefine creative approaches to documentary media and the opportunity to confront historic traditions of the documentary form.

text: Meaningful Witnessing in the United States, India & New Zealand: The Possibility Space for Digital Video Within Human Rights, Protest Movements and Activist Practices This dissertation examines the emergence of digital video practices rooted in human rights, social justice issues and protest movements through a number of select case studies in the United States, India and New Zealand. This project analyzes and critiques the formation of digital video practices through the lens of Manuel DeLanda’s interpretation of assemblage theory. Examining interactions between crucial elements present in a possibility space that aid in the cultivation and assembling of budding forms of digital video, this study considers the implications in the relationships between both material and expressive qualities of these assemblings. The central argument of this thesis asserts that digital video practices centered on human rights, social justice and protest movements require adaptable linkages between supportive structures, creative capacities and digital video technologies in order to produce sustainable and creative digital video practices buttressed by documentary agendas that fuel their dynamic evolution.

My research seeks to engage with the complexities of agency and technology and examines their significance in different contexts by providing a constructive outlet for practitioners to share the process behind their methods in order to offer insight into their creative workflow. Digital video technologies are proliferating at a rapid pace, yet very few video practices have formed that suggest linkages to documentary traditions. One can bear witness, yet to traverse video documentation in order to create a rhetorical argument of meaningful witnessing is a complex process that requires more than easy access to mobile video tools connected to the Internet. The case studies analyzed in these three democratic nations support the argument threaded throughout the project; digital video practices have the potential to thrive, albeit in pockets where formal or informal support systems are present and through assemblages where digital video technologies are constantly being adapted and an investment in human capital is paramount to the privileging of digital video tools or online platforms. Case studies that focus on individual practices in New York City and New Zealand reinforce the difficulties practitioners face when attempting to cultivate video practices without supportive structures. Comparatively with other case studies in India and New York, individual practices with long-term organizational support navigate challenges and re-assemble their practices in order to remain sustainable and influential.

This study also engages with assemblage theory in the context of documentary history and contemporary digital video practices and reassesses the historic relationship between emerging photographic, film and video tools and the lens based practitioners that harness these apparatuses for documentary purposes. Like assemblings themselves, these creative associations are never smooth at their inception, but require adaptable solutions and adjustable reassemblings in order to maintain the potential for sustainable practices to develop and flourish. This dissertation argues that as digital video practices continue to evolve, they have the potential to redefine creative approaches to documentary media and the opportunity to confront historic traditions of the documentary form.

year: 2015

title: He oranga tō te wai: Māori Pedagogies - A Culturally Responsive View of Aquatic Education and Drowning Prevention in Aotearoa

authors: Haimona, Mark Waihape

abstract: Drowning is a leading cause of accidental death and hospitalisation among Māori in Aotearoa. Drowning reports (Water Safety New Zealand, 2010, 2016, 2019) indicate Māori are over-represented in drowning compared to non-Māori, and on average account for up to a quarter of all drowning fatalities each year. Māori male aged 15-44 years and Māori children under five are most at risk of drowning (WSNZ, 2018, 2). A recent Aotearoa study on children’s water survival skills suggest changes are needed to improve how children develop fundamental aquatic skills and how teachers can best teach those skills (Button et al., 2017). In particular, the teaching of water safety skills for broader use in the open water environments of Aotearoa. 
Māori pedagogies within physical education, health, and education in the outdoors (Hemara, 2000; Jackson et al, 2016; Phillips, 2018) have demonstrated the benefits of Māori teaching methods that foster positive learning outcomes for Māori. (Bishop & Berryman, 2006, 2009). As such, this research investigated core components of Māori pedagogies that can improve aquatic education for Māori. It sought to validate traditional and contemporary aquatic teachings and water safety practices that Māori exercise as an expression of ira tangata (human development) and their relationship with te ao tūroa (the long-standing world). By means of kaupapa Māori research and the development of a new framework - Tāne Whānau Mārama, this thesis offers valuable insights into the importance of culturally responsive pedagogies in aquatic education that will enhance the health, educational achievements, and well-being of Māori whānau and communities.

text: He oranga tō te wai: Māori Pedagogies - A Culturally Responsive View of Aquatic Education and Drowning Prevention in Aotearoa Drowning is a leading cause of accidental death and hospitalisation among Māori in Aotearoa. Drowning reports (Water Safety New Zealand, 2010, 2016, 2019) indicate Māori are over-represented in drowning compared to non-Māori, and on average account for up to a quarter of all drowning fatalities each year. Māori male aged 15-44 years and Māori children under five are most at risk of drowning (WSNZ, 2018, 2). A recent Aotearoa study on children’s water survival skills suggest changes are needed to improve how children develop fundamental aquatic skills and how teachers can best teach those skills (Button et al., 2017). In particular, the teaching of water safety skills for broader use in the open water environments of Aotearoa. 
Māori pedagogies within physical education, health, and education in the outdoors (Hemara, 2000; Jackson et al, 2016; Phillips, 2018) have demonstrated the benefits of Māori teaching methods that foster positive learning outcomes for Māori. (Bishop & Berryman, 2006, 2009). As such, this research investigated core components of Māori pedagogies that can improve aquatic education for Māori. It sought to validate traditional and contemporary aquatic teachings and water safety practices that Māori exercise as an expression of ira tangata (human development) and their relationship with te ao tūroa (the long-standing world). By means of kaupapa Māori research and the development of a new framework - Tāne Whānau Mārama, this thesis offers valuable insights into the importance of culturally responsive pedagogies in aquatic education that will enhance the health, educational achievements, and well-being of Māori whānau and communities.

year: 2023