title: Interface design strategies for computer-assisted speech transcription

authors: Luz, Saturnino

subjects: computer science

abstract: A set of user interface design techniques for computer-assisted speech transcription are presented and evaluated with respect to task performance and usability. These techniques include error-correction mechanisms which originated in dictation systems and audio editors as well as new techniques developed by us which exploit specific characteristics of existing speech recognition technologies in order to facilitate transcription in settings that typically yield considerable recognition inaccuracy, such as when the speech to be transcribed was produced by different speakers. In particular, we describe a mechanism for dynamic propagation of user feedback which progressively adapts the system to different speakers and lexical contexts. Results of usability and performance evaluation trials indicate that feedback propagation, menu-based correction coupled with keyboard interaction and text-driven audio playback are positively perceived by users and result in improved transcript accuracy.

text: Interface design strategies for computer-assisted speech transcription A set of user interface design techniques for computer-assisted speech transcription are presented and evaluated with respect to task performance and usability. These techniques include error-correction mechanisms which originated in dictation systems and audio editors as well as new techniques developed by us which exploit specific characteristics of existing speech recognition technologies in order to facilitate transcription in settings that typically yield considerable recognition inaccuracy, such as when the speech to be transcribed was produced by different speakers. In particular, we describe a mechanism for dynamic propagation of user feedback which progressively adapts the system to different speakers and lexical contexts. Results of usability and performance evaluation trials indicate that feedback propagation, menu-based correction coupled with keyboard interaction and text-driven audio playback are positively perceived by users and result in improved transcript accuracy.

year: 2008

title: Novel sulfonamides for the treatment of breast and cervical cancers

authors: Buckley, Nathaniel Thomas

subjects: Sulfonamide

abstract: A series of novel sulfonamides were studied computationally to identify a potential mechanism of action for the treatment of breast and cervical cancers. Previous in vivo testing demonstrated varying degrees of effectiveness, with seven molecules showing the highest cytotoxicity. Computational calculations were chosen as the means for determining the drug target. Previous studies indicated β-Tubulin and Carbonic Anhydrase IX as the most likely proteins of interest, so these were selected for study.
The computational methodology selected for this study follows that of Krzywik et al.¹ For this, conventional docking studies were undertaken using Autodock Vina, followed by more accurate and computationally demanding molecular dynamics simulations using the MM/PBSA procedures in AMBER. Docking studies for the seven active compounds were performed using Vina, and showed promising results. The three most effective compounds (5AP, 6AP and 7BP) were then utilised in a series of MM/PBSA calculations to determine strength of interaction between the sulfonamides and drug targets.
The results of the AMBER calculations determined β-Tubulin to be the more likely drug target, although this result did show 6AP (the most effective in vivo molecule) to have the weakest binding, which was an unexpected result. A LIGPLOT study was done to determine a potential cause for this, showing a heavy emphasis on non-polar interactions between the drug molecules and proteins. Drug-like comparisons and pKa calculations were also performed, showing all three molecules to have very similar acidity and hydrogen bond capabilities, but suggesting lipophilicity and molecule size to be possible determining factors in the overall effect of the compounds. Transport across the cell membrane and through the cytoplasm were also suggested as potential reasons for the differing results, and further studies into these were suggested for possible confirmation.

text: Novel sulfonamides for the treatment of breast and cervical cancers A series of novel sulfonamides were studied computationally to identify a potential mechanism of action for the treatment of breast and cervical cancers. Previous in vivo testing demonstrated varying degrees of effectiveness, with seven molecules showing the highest cytotoxicity. Computational calculations were chosen as the means for determining the drug target. Previous studies indicated β-Tubulin and Carbonic Anhydrase IX as the most likely proteins of interest, so these were selected for study.
The computational methodology selected for this study follows that of Krzywik et al.¹ For this, conventional docking studies were undertaken using Autodock Vina, followed by more accurate and computationally demanding molecular dynamics simulations using the MM/PBSA procedures in AMBER. Docking studies for the seven active compounds were performed using Vina, and showed promising results. The three most effective compounds (5AP, 6AP and 7BP) were then utilised in a series of MM/PBSA calculations to determine strength of interaction between the sulfonamides and drug targets.
The results of the AMBER calculations determined β-Tubulin to be the more likely drug target, although this result did show 6AP (the most effective in vivo molecule) to have the weakest binding, which was an unexpected result. A LIGPLOT study was done to determine a potential cause for this, showing a heavy emphasis on non-polar interactions between the drug molecules and proteins. Drug-like comparisons and pKa calculations were also performed, showing all three molecules to have very similar acidity and hydrogen bond capabilities, but suggesting lipophilicity and molecule size to be possible determining factors in the overall effect of the compounds. Transport across the cell membrane and through the cytoplasm were also suggested as potential reasons for the differing results, and further studies into these were suggested for possible confirmation.

year: 2022

title: Linking land, river and moana: Collaborative research between Te Whakatōhea and Lincoln University within the coastal rohe

authors: Morris, Richard

abstract: In the eastern Bay of Plenty, where the land yields to the Pacific and the Waioeka and Ōtara Rivers meet Te Moana aToi (the Bay of Plenty), a research partnership is flourishing between Te Whakatōhea iwi, Lincoln University Centre of Excellence Designing Future Productive Landscape (DFPL), and Waikato University. This collaboration has grown over several years into a suite of multidisciplinary research projects focused on agricultural systems design, urban planning, and climate resilience. While distinct in their objectives, these research threads are united by a deeper, unavoidable theme: the interconnection between whenua (land), awa (river), and moana (sea). For Te Whakatōhea, these are not separate domains but a continuous space of identity, sustenance, and economy, an ethos that sits well with DFPL.

text: Linking land, river and moana: Collaborative research between Te Whakatōhea and Lincoln University within the coastal rohe In the eastern Bay of Plenty, where the land yields to the Pacific and the Waioeka and Ōtara Rivers meet Te Moana aToi (the Bay of Plenty), a research partnership is flourishing between Te Whakatōhea iwi, Lincoln University Centre of Excellence Designing Future Productive Landscape (DFPL), and Waikato University. This collaboration has grown over several years into a suite of multidisciplinary research projects focused on agricultural systems design, urban planning, and climate resilience. While distinct in their objectives, these research threads are united by a deeper, unavoidable theme: the interconnection between whenua (land), awa (river), and moana (sea). For Te Whakatōhea, these are not separate domains but a continuous space of identity, sustenance, and economy, an ethos that sits well with DFPL.

year: 2025-11