title: Synthesis and crystal structure of the first complex containing a chelating selenourea dianion ligand

authors: Nicholson, Brian K.

subjects: Platinum complexes

abstract: Reaction of N,N′-diphenylselenourea, PhNHC(Se)NHPh, with cis-[PtCl2(PPh3)2] and triethylamine in hot methanol gives the first example of a selenourea dianion complex, [Pt{SeC(=NPh)NPh}(PPh3)2] isolated as a yellow solid in high yield. The structure of the complex was determined by X-ray crystallography and found to be similar to the related thiourea dianion complex [Pt{SC(=NPh)NPh}(PPh3)2], with a Pt---Se---C---N four-membered ring. The antitumour activity (P388 murine leukaemia cells) of the selenourea dianion complex was determined, together with a small selection of related platinum(II)-thiourea dianion complexes (prepared by an analogous method) for comparison. The complex [Pt{SC(=NMe)NMe}(PPh3)2] showed high activity [IC50 1.0 μM], with the other complexes showing moderate to low activity.

text: Synthesis and crystal structure of the first complex containing a chelating selenourea dianion ligand Reaction of N,N′-diphenylselenourea, PhNHC(Se)NHPh, with cis-[PtCl2(PPh3)2] and triethylamine in hot methanol gives the first example of a selenourea dianion complex, [Pt{SeC(=NPh)NPh}(PPh3)2] isolated as a yellow solid in high yield. The structure of the complex was determined by X-ray crystallography and found to be similar to the related thiourea dianion complex [Pt{SC(=NPh)NPh}(PPh3)2], with a Pt---Se---C---N four-membered ring. The antitumour activity (P388 murine leukaemia cells) of the selenourea dianion complex was determined, together with a small selection of related platinum(II)-thiourea dianion complexes (prepared by an analogous method) for comparison. The complex [Pt{SC(=NMe)NMe}(PPh3)2] showed high activity [IC50 1.0 μM], with the other complexes showing moderate to low activity.

year: 2003-11-01

title: Richard Rolle, Emendatio vitae: Amendinge of Lyf, a Middle English translation, edited from Dublin, Trinity College, MS 432

authors: Kempster, John Hugh

subjects: Richard Rolle

abstract: Emendatio vitae was the most widely copied of all Richard Rolle’s writings in fourteenth and fifteenth-century England, and yet in modern scholarship this important work and its early audience have received comparatively little scholarly attention. My aim has been to address this lacuna by producing an edition of one of the seven Middle English translations of the text - Amendinge of Lyf - with notes and glossary. In an introductory study I adopt a dual focus: Rolle’s intended audience, and the actual early readers of this particular Middle English translation. Firstly, I conclude that Rolle may have intended Emendatio vitae as a work of ‘pastoralia’, for secular priests, and therefore with a wider audience of the laity also in mind. This being the case, it demonstrates that the adaptation of traditionally eremitic contemplative writings for a general audience, so widespread in the fifteenth-century, was already stirring in Rolle’s day. Secondly, I look in detail at a specific crosssection of Rolle’s early readership: a translator, several scribes and correctors, and other early readers and owners. The striking thing about this segment of the text’s reception is its breadth, including a priest, a number of prominent lay women and men, and by the end of the fifteenth-century also Dominican and Benedictine nuns.

text: Richard Rolle, Emendatio vitae: Amendinge of Lyf, a Middle English translation, edited from Dublin, Trinity College, MS 432 Emendatio vitae was the most widely copied of all Richard Rolle’s writings in fourteenth and fifteenth-century England, and yet in modern scholarship this important work and its early audience have received comparatively little scholarly attention. My aim has been to address this lacuna by producing an edition of one of the seven Middle English translations of the text - Amendinge of Lyf - with notes and glossary. In an introductory study I adopt a dual focus: Rolle’s intended audience, and the actual early readers of this particular Middle English translation. Firstly, I conclude that Rolle may have intended Emendatio vitae as a work of ‘pastoralia’, for secular priests, and therefore with a wider audience of the laity also in mind. This being the case, it demonstrates that the adaptation of traditionally eremitic contemplative writings for a general audience, so widespread in the fifteenth-century, was already stirring in Rolle’s day. Secondly, I look in detail at a specific crosssection of Rolle’s early readership: a translator, several scribes and correctors, and other early readers and owners. The striking thing about this segment of the text’s reception is its breadth, including a priest, a number of prominent lay women and men, and by the end of the fifteenth-century also Dominican and Benedictine nuns.

year: 2007

title: Tangihanga: Through the eyes of young Maori women

authors: Wihongi, Hemaima

subjects: tangihanga

abstract: Tangihanga describes the Māori customary way of approaching death. The aim of this research is to explore the tangihanga experiences of young Māori women. The meanings they create, the learning they experience, and the social relationships they negotiate whilst at tangihanga are of interest. The contribution that tangihanga makes to mediating bereavement, grief and loss will also be investigated. This research seeks to broaden the understanding around the practices, beliefs and meanings that are associated with the processes of Tangihanga as experienced by young Māori women.
This study interviewed young Māori women between the ages of eighteen to twenty four. Face to face interviews were carried out with the use of a semi-structured interview schedule. The interviews provided access to the participant‟s experiences and understanding of tangihanga and the customary practices that are associated with it.
The findings from this study support the notion that the tangihanga is a fundamental event for Māori. The participants found tangi to be a place where their relationships within both their immediate and extended whānau were strengthened. This setting allowed the young women to express their grief in an open and supportive environment surrounded by their whānau. The tangi also provided a place of learning for the young women as they learned about the tikanga and kawa or customary practices in relation to tangihanga. This learning occurred in a number of ways; by observation, through participation and the receiving of instruction from older family members. Thus the tangi provided the opportunity for the transfer of cultural knowledge between generations. These findings suggest that the tangi plays an important role in young women‟s lives as it provides them with access to Māori communities and cultural learning. The challenge for us today is to ensure that these opportunities continue to occur for young Māori women.

text: Tangihanga: Through the eyes of young Maori women Tangihanga describes the Māori customary way of approaching death. The aim of this research is to explore the tangihanga experiences of young Māori women. The meanings they create, the learning they experience, and the social relationships they negotiate whilst at tangihanga are of interest. The contribution that tangihanga makes to mediating bereavement, grief and loss will also be investigated. This research seeks to broaden the understanding around the practices, beliefs and meanings that are associated with the processes of Tangihanga as experienced by young Māori women.
This study interviewed young Māori women between the ages of eighteen to twenty four. Face to face interviews were carried out with the use of a semi-structured interview schedule. The interviews provided access to the participant‟s experiences and understanding of tangihanga and the customary practices that are associated with it.
The findings from this study support the notion that the tangihanga is a fundamental event for Māori. The participants found tangi to be a place where their relationships within both their immediate and extended whānau were strengthened. This setting allowed the young women to express their grief in an open and supportive environment surrounded by their whānau. The tangi also provided a place of learning for the young women as they learned about the tikanga and kawa or customary practices in relation to tangihanga. This learning occurred in a number of ways; by observation, through participation and the receiving of instruction from older family members. Thus the tangi provided the opportunity for the transfer of cultural knowledge between generations. These findings suggest that the tangi plays an important role in young women‟s lives as it provides them with access to Māori communities and cultural learning. The challenge for us today is to ensure that these opportunities continue to occur for young Māori women.

year: 2013