title: Modelling single cell electroporation with bipolar pulse parameters and dynamic pore radii

authors: Talele, Sadhana

subjects: electroporation

abstract: We develop a model of single spherical cell electroporation and simulate spatial and temporal aspects of the transmembrane potential and pore radii as an effect of any form of applied electric field. The extent of electroporation in response to sinusoidal electric pulses of two different frequencies in a range of extracellular conductivity for two different cell radii are compared. Results show that pore radii tend to be more normalized for AC fields. The relative difference in fractional pore area is reduced by the use of a 1 MHz sinusoidal applied electric field over a 100 kHz field.

text: Modelling single cell electroporation with bipolar pulse parameters and dynamic pore radii We develop a model of single spherical cell electroporation and simulate spatial and temporal aspects of the transmembrane potential and pore radii as an effect of any form of applied electric field. The extent of electroporation in response to sinusoidal electric pulses of two different frequencies in a range of extracellular conductivity for two different cell radii are compared. Results show that pore radii tend to be more normalized for AC fields. The relative difference in fractional pore area is reduced by the use of a 1 MHz sinusoidal applied electric field over a 100 kHz field.

year: 2010

title: On the supply-side of determinants of regional growth

authors: McCann, Philip

subjects: economic theory

abstract: The major developments in thought regarding regional economic growth and development are traced over the last two decades. The supply-side micro-foundations of regional growth have come under scrutiny in a manner which has previously not been evident. In particular, an examination of the elements of industrial clustering, regional industrial structure, and place characteristics which may promote innovation, have become a central focus of modern regional growth analysis. The micro-foundations of these arguments are analysed, and the links between innovation and clustering explored within a transactions-costs framework. This allows us to point to areas in which our understanding has grown over recent years, and to identify further areas of analysis which are required.

text: On the supply-side of determinants of regional growth The major developments in thought regarding regional economic growth and development are traced over the last two decades. The supply-side micro-foundations of regional growth have come under scrutiny in a manner which has previously not been evident. In particular, an examination of the elements of industrial clustering, regional industrial structure, and place characteristics which may promote innovation, have become a central focus of modern regional growth analysis. The micro-foundations of these arguments are analysed, and the links between innovation and clustering explored within a transactions-costs framework. This allows us to point to areas in which our understanding has grown over recent years, and to identify further areas of analysis which are required.

year: 2006

title: The art of dialogue with indigenous communities in the new biotechnology world

authors: Hudson, Maui

subjects: biotechnology

abstract: Te Hau Mihi Ata is a research project that aims to negotiate spaces for and develop processes of dialogue that allow for a deeper level of interaction between mtauranga Māori (Māori indigenous knowledge) and science. Over a two-year period a series of facilitated exchanges or wnanga were held focusing on areas of new technology (assisted reproductive technologies, life technologies, and future food technologies) that involved Māori scientists and people with expertise in mtauranga Māori. These dialogue events were designed to explore, through the challenge of considering new biotechnologies, the similarities and differences that emerge from approaching these issues from different knowledge paradigms. This paper will outline the key project findings from this series of exchanges including the barriers and facilitators to the dialogue process and knowledge exchange as well as discuss how participants created connections between scientific discourse and indigenous knowledge frameworks.

text: The art of dialogue with indigenous communities in the new biotechnology world Te Hau Mihi Ata is a research project that aims to negotiate spaces for and develop processes of dialogue that allow for a deeper level of interaction between mtauranga Māori (Māori indigenous knowledge) and science. Over a two-year period a series of facilitated exchanges or wnanga were held focusing on areas of new technology (assisted reproductive technologies, life technologies, and future food technologies) that involved Māori scientists and people with expertise in mtauranga Māori. These dialogue events were designed to explore, through the challenge of considering new biotechnologies, the similarities and differences that emerge from approaching these issues from different knowledge paradigms. This paper will outline the key project findings from this series of exchanges including the barriers and facilitators to the dialogue process and knowledge exchange as well as discuss how participants created connections between scientific discourse and indigenous knowledge frameworks.

year: 2012