title: Honey: Antimicrobial actions and role in disease management

authors: Molan, Peter C.

subjects: honey

abstract: The ancient treatment of dressing infected wounds with honey is rapidly becoming re-established in professional medicine, especially where wounds are infected with antibiotic-resistant bacteria. This is because of the demonstrated sensitivity of such bacteria to the antibacterial activity of honey, which is not influenced by whether or not strains are resistant to antibiotics. Honey has been found to have a very broad spectrum of activity, but its potency of antibacterial activity can vary greatly. In most honeys the antibacterial activity is due to enzymatically produced hydrogen peroxide and thus the potency of its antibacterial activity can be decreased by catalase present in an open wound. Manuka honey has an antibacterial component derived from the plant source. Manuka honey with a quality-assured level of antibacterial activity is being used by companies marketing honey products for wound care that are registered with the medical regulatory authorities in various countries. Such honey can be diluted IO-fold or more and still completely inhibit the usual wound-infecting species. There is a large amount of clinical evidence for the effectiveness of honey in clearing infection in wounds, and some clinical evidence of its effectiveness in treating other infections. Although the antibacterial potency of honey is insufficient to allow its use systemically, there are various clinical applications besides wound care in which it is used topically or where it does not get excessively diluted, such as for treatment of gastritis, enteritis, gingivitis, ophthalmological infections and bronchial infections. In most of these applications the anti-inflammatory activity of honey is of additional benefit in decreasing the inflammation resulting from infection. Additional clinical research is needed to provide better evidence of the effectiveness of honey in these therapeutic applications of honey.

text: Honey: Antimicrobial actions and role in disease management The ancient treatment of dressing infected wounds with honey is rapidly becoming re-established in professional medicine, especially where wounds are infected with antibiotic-resistant bacteria. This is because of the demonstrated sensitivity of such bacteria to the antibacterial activity of honey, which is not influenced by whether or not strains are resistant to antibiotics. Honey has been found to have a very broad spectrum of activity, but its potency of antibacterial activity can vary greatly. In most honeys the antibacterial activity is due to enzymatically produced hydrogen peroxide and thus the potency of its antibacterial activity can be decreased by catalase present in an open wound. Manuka honey has an antibacterial component derived from the plant source. Manuka honey with a quality-assured level of antibacterial activity is being used by companies marketing honey products for wound care that are registered with the medical regulatory authorities in various countries. Such honey can be diluted IO-fold or more and still completely inhibit the usual wound-infecting species. There is a large amount of clinical evidence for the effectiveness of honey in clearing infection in wounds, and some clinical evidence of its effectiveness in treating other infections. Although the antibacterial potency of honey is insufficient to allow its use systemically, there are various clinical applications besides wound care in which it is used topically or where it does not get excessively diluted, such as for treatment of gastritis, enteritis, gingivitis, ophthalmological infections and bronchial infections. In most of these applications the anti-inflammatory activity of honey is of additional benefit in decreasing the inflammation resulting from infection. Additional clinical research is needed to provide better evidence of the effectiveness of honey in these therapeutic applications of honey.

year: 2009

title: Context-specific bioturbation mediates changes to ecosystem functioning

authors: Needham, Hazel Rosemary

subjects: benthic–pelagic coupling

abstract: Species are often grouped according to their biological or functional traits to better understand their contribution to ecosystem functioning. However, it is becoming clear that a single species can perform different roles in different habitats. Austrohelice crassa, a burrow-building mud crab shifts its primary bioturbational role to that of a vertical mixer in non-cohesive sediments as frequent burrow collapse greatly enhances sediment reworking. We conducted in situ crab density manipulations in two sediment environments (a non-cohesive sand and a cohesive muddy-sand) to examine if the contextspecific functional roles were linked to changes in solute fluxes across the sediment–water interface. Across both habitats, we show that A. crassa regulated nutrient cycling, creating strong density driven effects on solute exchanges. Increasing crab density increased sediment O₂ demand and the flux of NH₄⁺ from the sediment, indicating much of the response was physiologically driven. Clear interactions between A. crassa and microphytobenthos were also detected in both habitats. Despite lowering microphyte standing stock through deposit feeding, A. crassa increased benthic primary production per unit of chlorophyll a. Our experiment also revealed important context-specific differences, most notably for NH₄⁺ fluxes, which were higher where burrows and their associated microbial communities were most stable (muddy-sand). This study highlights the need to integrate interactions between organism behavior and habitat type into functional group studies to broaden conceptual frameworks and avoid oversimplification of highly complex organism–sediment interactions.

text: Context-specific bioturbation mediates changes to ecosystem functioning Species are often grouped according to their biological or functional traits to better understand their contribution to ecosystem functioning. However, it is becoming clear that a single species can perform different roles in different habitats. Austrohelice crassa, a burrow-building mud crab shifts its primary bioturbational role to that of a vertical mixer in non-cohesive sediments as frequent burrow collapse greatly enhances sediment reworking. We conducted in situ crab density manipulations in two sediment environments (a non-cohesive sand and a cohesive muddy-sand) to examine if the contextspecific functional roles were linked to changes in solute fluxes across the sediment–water interface. Across both habitats, we show that A. crassa regulated nutrient cycling, creating strong density driven effects on solute exchanges. Increasing crab density increased sediment O₂ demand and the flux of NH₄⁺ from the sediment, indicating much of the response was physiologically driven. Clear interactions between A. crassa and microphytobenthos were also detected in both habitats. Despite lowering microphyte standing stock through deposit feeding, A. crassa increased benthic primary production per unit of chlorophyll a. Our experiment also revealed important context-specific differences, most notably for NH₄⁺ fluxes, which were higher where burrows and their associated microbial communities were most stable (muddy-sand). This study highlights the need to integrate interactions between organism behavior and habitat type into functional group studies to broaden conceptual frameworks and avoid oversimplification of highly complex organism–sediment interactions.

year: 2011

title: Restoring Indigneous Law and Justice Traditions

authors: Cook, Michelle Lynn

subjects: Indigenous peoples

abstract: Restoring indigenous people's law and their ability to practice their justice traditions is a fundamental aspect of non-discrimination, decolonization, self-governance, self-determination, and social justice. The critical application and interpretation of indigenous people's law has revolutionary potentiality to transform, confront, and heal multiple forms of oppression such as environmental destruction, patriarchy, and the prison/criminal justice system. The sovereign jurisgenerative (law making) power of indigenous peoples is a site of profound hope for the revitalization of indigenous law and justice traditions restores legal principles and values of sacredness, harmony, balance, and interconnectivity within human relationships and with the natural world. Revitalizing indigenous law is a way to re-construct the self and society while also finding and re-connecting to new/old ways of being human. This thesis focuses on both Navajo and Māori practices and visions of law and justice; the challenges and, successes they have faced and the hopes they have of living by their law. Indigenous peoples, their ways of being, their wisdom, laws, and philosophies, must be respected, protected, and preserved not only because they contribute to humanity's richness and cultural diversity but also because they are living examples of  a more just, dignified, and ecologically sustainable society, which can serve all humanity.

text: Restoring Indigneous Law and Justice Traditions Restoring indigenous people's law and their ability to practice their justice traditions is a fundamental aspect of non-discrimination, decolonization, self-governance, self-determination, and social justice. The critical application and interpretation of indigenous people's law has revolutionary potentiality to transform, confront, and heal multiple forms of oppression such as environmental destruction, patriarchy, and the prison/criminal justice system. The sovereign jurisgenerative (law making) power of indigenous peoples is a site of profound hope for the revitalization of indigenous law and justice traditions restores legal principles and values of sacredness, harmony, balance, and interconnectivity within human relationships and with the natural world. Revitalizing indigenous law is a way to re-construct the self and society while also finding and re-connecting to new/old ways of being human. This thesis focuses on both Navajo and Māori practices and visions of law and justice; the challenges and, successes they have faced and the hopes they have of living by their law. Indigenous peoples, their ways of being, their wisdom, laws, and philosophies, must be respected, protected, and preserved not only because they contribute to humanity's richness and cultural diversity but also because they are living examples of  a more just, dignified, and ecologically sustainable society, which can serve all humanity.

year: 2010