title: Perspectives and expectations of person-centred and equitable cancer nursing care

authors: Leow, Clara

subjects: Person-centred

abstract: Abstract
Background: The rising prevalence of cancer in New Zealand calls for a need to improve person-centred and equitable cancer nursing care, in order to enhance patient outcomes and alleviate burden on the healthcare system. However, achieving this can prove to be a challenge due to the increase in cultural diversity amongst patients and nurses. Therefore, understanding and embracing the perspectives and expectations of both patients and nurses would be beneficial and crucial to raising awareness and bridging gaps that could jeopardise person-centred and equitable cancer nursing care. With only one inpatient ward within the region, the acute Haematology and Oncology ward within Health New Zealand - Te Whatu Ora Waikato is no exception to these challenges. 

Objective: This research aims to explore the perspectives and expectations of patients and nurses in an acute Haematology and Oncology ward within Health New Zealand - Te Whatu Ora Waikato.

Participants: Six patients from the inpatient ward were purposefully recruited in the qualitative phase according to the sampling framework, and through the application of inclusion, and exclusion criteria. All 53 registered nurses were invited to participate in an anonymous online survey during the quantitative phase. However, only 15 registered nurses responded. 

Methods: This exploratory sequential mixed methods research consisted of an initial qualitative phase that explored the perspectives and expectations of patients using semi-structured interviews. Braun and Clarke’s reflexive thematic analysis was utilised to identify themes from the interviews. An anonymous online Likert scale survey was then developed for registered nurses in the quantitative phase. Data from the surveys were analysed using descriptive statistics. 

Findings: Four main themes emerged from patient interviews as important aspects of person-centred and equitable cancer care to patients: (i) Holistic needs and care, (ii) Involving and engaging support system, (iii) Barriers and challenges, and (iv) Nursing roles and patient engagement. However, findings from staff surveys revealed that nurses had varying perspectives and were not consistently providing care that patients valued. When both data sets were compared, it was evident that there were significant misalignments in the perspectives and expectations of person-centred and equitable care between patients and nurses. 

Conclusion: Understanding and embracing the perspectives and expectations of patients and nurses in cancer care is a pivotal aspect to achieving person-centred and equitable care in New Zealand. However, barriers such as misaligned perspectives and expectations between patients and nurses can negatively impact the delivery of individualised care. As a result, this increases the risk for more unfavourable treatment outcomes and complications, thereby also placing more pressure on the already strained healthcare system. While this study has provided valuable insights, further research may be required to increase the generalisability and robustness of this topic. In addition, implementation of strategies, and interventions to encourage the alignment of perspectives and expectations between patients and nurses should also be explored at different levels of cancer care, including the incorporation of policy, educational and clinical support.

text: Perspectives and expectations of person-centred and equitable cancer nursing care Abstract
Background: The rising prevalence of cancer in New Zealand calls for a need to improve person-centred and equitable cancer nursing care, in order to enhance patient outcomes and alleviate burden on the healthcare system. However, achieving this can prove to be a challenge due to the increase in cultural diversity amongst patients and nurses. Therefore, understanding and embracing the perspectives and expectations of both patients and nurses would be beneficial and crucial to raising awareness and bridging gaps that could jeopardise person-centred and equitable cancer nursing care. With only one inpatient ward within the region, the acute Haematology and Oncology ward within Health New Zealand - Te Whatu Ora Waikato is no exception to these challenges. 

Objective: This research aims to explore the perspectives and expectations of patients and nurses in an acute Haematology and Oncology ward within Health New Zealand - Te Whatu Ora Waikato.

Participants: Six patients from the inpatient ward were purposefully recruited in the qualitative phase according to the sampling framework, and through the application of inclusion, and exclusion criteria. All 53 registered nurses were invited to participate in an anonymous online survey during the quantitative phase. However, only 15 registered nurses responded. 

Methods: This exploratory sequential mixed methods research consisted of an initial qualitative phase that explored the perspectives and expectations of patients using semi-structured interviews. Braun and Clarke’s reflexive thematic analysis was utilised to identify themes from the interviews. An anonymous online Likert scale survey was then developed for registered nurses in the quantitative phase. Data from the surveys were analysed using descriptive statistics. 

Findings: Four main themes emerged from patient interviews as important aspects of person-centred and equitable cancer care to patients: (i) Holistic needs and care, (ii) Involving and engaging support system, (iii) Barriers and challenges, and (iv) Nursing roles and patient engagement. However, findings from staff surveys revealed that nurses had varying perspectives and were not consistently providing care that patients valued. When both data sets were compared, it was evident that there were significant misalignments in the perspectives and expectations of person-centred and equitable care between patients and nurses. 

Conclusion: Understanding and embracing the perspectives and expectations of patients and nurses in cancer care is a pivotal aspect to achieving person-centred and equitable care in New Zealand. However, barriers such as misaligned perspectives and expectations between patients and nurses can negatively impact the delivery of individualised care. As a result, this increases the risk for more unfavourable treatment outcomes and complications, thereby also placing more pressure on the already strained healthcare system. While this study has provided valuable insights, further research may be required to increase the generalisability and robustness of this topic. In addition, implementation of strategies, and interventions to encourage the alignment of perspectives and expectations between patients and nurses should also be explored at different levels of cancer care, including the incorporation of policy, educational and clinical support.

year: 2025

title: Deactivation of TEM-1 beta-Lactamase investigated by isothermal batch and non-isothermal continuous enzyme membrane reactor methods

authors: Rogers, Thomas A.

subjects: biocatalysis

abstract: The thermal deactivation of TEM-1 β-lactamase was examined using two experimental techniques: a series of isothermal batch assays and a single, continuous, non-isothermal assay in an enzyme membrane reactor (EMR). The isothermal batch-mode technique was coupled with the three-state  Equilibrium Model  of enzyme deactivation, while the results of the EMR experiment were fitted to a four-state  molten globule model . The two methods both led to the conclusions that the thermal deactivation of TEM-1 β -lactamase does not follow the Lumry-Eyring model and that the Teq of the enzyme (the point at which active and inactive states are present in equal amounts due to thermodynamic equilibrium) is at least 10 °C from the Tm (melting temperature), contrary to the idea that the true temperature optimum of a biocatalyst is necessarily close to the melting temperature.

text: Deactivation of TEM-1 beta-Lactamase investigated by isothermal batch and non-isothermal continuous enzyme membrane reactor methods The thermal deactivation of TEM-1 β-lactamase was examined using two experimental techniques: a series of isothermal batch assays and a single, continuous, non-isothermal assay in an enzyme membrane reactor (EMR). The isothermal batch-mode technique was coupled with the three-state  Equilibrium Model  of enzyme deactivation, while the results of the EMR experiment were fitted to a four-state  molten globule model . The two methods both led to the conclusions that the thermal deactivation of TEM-1 β -lactamase does not follow the Lumry-Eyring model and that the Teq of the enzyme (the point at which active and inactive states are present in equal amounts due to thermodynamic equilibrium) is at least 10 °C from the Tm (melting temperature), contrary to the idea that the true temperature optimum of a biocatalyst is necessarily close to the melting temperature.

year: 2009

title: Research and development absorptive capacity: a Māori perspective

authors: Ruckstuhl, Katharina

subjects: computer science

abstract: This paper presents a view of research and development absorptive capacity from a Māori perspective. The assessment is part of a case study of a longitudinal programme – Science for Technological Innovation: Kia kotahi mai – Te Ao Putaiao me te Ao Hanagarau that aims to increase Aotearoa New Zealand’s capacity to use sci-tech for economic benefit. The paper finds that while Aotearoa New Zealand’s macro policy and meso institutional levels have become more responsive to Māori research and development demands, at the micro level of the individual or the firm there are still constraints given the small numbers of Māori in science, technology, engineering and mathematics. In response to this, a novel model of Māori sci-tech capacity is under development that considers not only research and development technical capacities, but also the human and relational capacities required to accelerate absorptive capacity to respond to Māori social and economic aspirations.

text: Research and development absorptive capacity: a Māori perspective This paper presents a view of research and development absorptive capacity from a Māori perspective. The assessment is part of a case study of a longitudinal programme – Science for Technological Innovation: Kia kotahi mai – Te Ao Putaiao me te Ao Hanagarau that aims to increase Aotearoa New Zealand’s capacity to use sci-tech for economic benefit. The paper finds that while Aotearoa New Zealand’s macro policy and meso institutional levels have become more responsive to Māori research and development demands, at the micro level of the individual or the firm there are still constraints given the small numbers of Māori in science, technology, engineering and mathematics. In response to this, a novel model of Māori sci-tech capacity is under development that considers not only research and development technical capacities, but also the human and relational capacities required to accelerate absorptive capacity to respond to Māori social and economic aspirations.

year: 2019