title: A porous fluoride-substituted bovine-derived hydroxyapatite scaffold constructed for applications in bone tissue regeneration

authors: Ratnayake, Jithendra

subjects: biocompatibility

abstract: Hydroxyapatite is widely used in bone implantation because of its similar mineral composition to natural bone, allowing it to serve as a biocompatible osteoconductive support. A bovine-derived hydroxyapatite (BHA) scaffold was developed through an array of defatting and deproteinization procedures. The BHA scaffold was substituted with fluoride ions using a modified sol-gel method to produce a bovine-derived fluorapatite (BFA) scaffold. Fourier-transform infrared spectroscopy and X-ray diffraction analysis showed that fluoride ions were successfully substituted into the BHA lattice. According to energy dispersive X-ray analysis, the main inorganic phases contained calcium and phosphorus with a fluoride ratio of ~1–2 wt%. Scanning electron microscopy presented a natural microporous architecture for the BFA scaffold with pore sizes ranging from ~200–600 μm. The BHA scaffold was chemically stable and showed sustained degradation in simulated-body fluid. Young’s modulus and yield strength were superior in the BFA scaffold to BHA. In vitro cell culture studies showed that the BFA was biocompatible, supporting the proliferative growth of Saos-2 osteoblast cells and exhibiting osteoinductive features. This unique technique of producing hydroxyapatite from bovine bone with the intent of producing high performance biomedically targeted materials could be used to improve bone repair.

text: A porous fluoride-substituted bovine-derived hydroxyapatite scaffold constructed for applications in bone tissue regeneration Hydroxyapatite is widely used in bone implantation because of its similar mineral composition to natural bone, allowing it to serve as a biocompatible osteoconductive support. A bovine-derived hydroxyapatite (BHA) scaffold was developed through an array of defatting and deproteinization procedures. The BHA scaffold was substituted with fluoride ions using a modified sol-gel method to produce a bovine-derived fluorapatite (BFA) scaffold. Fourier-transform infrared spectroscopy and X-ray diffraction analysis showed that fluoride ions were successfully substituted into the BHA lattice. According to energy dispersive X-ray analysis, the main inorganic phases contained calcium and phosphorus with a fluoride ratio of ~1–2 wt%. Scanning electron microscopy presented a natural microporous architecture for the BFA scaffold with pore sizes ranging from ~200–600 μm. The BHA scaffold was chemically stable and showed sustained degradation in simulated-body fluid. Young’s modulus and yield strength were superior in the BFA scaffold to BHA. In vitro cell culture studies showed that the BFA was biocompatible, supporting the proliferative growth of Saos-2 osteoblast cells and exhibiting osteoinductive features. This unique technique of producing hydroxyapatite from bovine bone with the intent of producing high performance biomedically targeted materials could be used to improve bone repair.

year: 2024-02-28

title: Landform classification of the Mamaku Plateau using a digital elevation model.

authors: Bakker, L.

abstract: The Mamaku Plateau is a large, forest-covered ignimbrite plateau in the North Island of New Zealand. This study was launched to aid inquiries into the evolu-tion of the plateau by classifying its valleys (which con-stitute Mamaku’s main geomorphological feature).An automatic classification of the valley forms in the Mamaku Plateau was made using a Digital Elevation Model (DEM). A new algorithm was created for the Arc/Info Geographic Information System, to extract the valleys from the DEM. Preliminary results from this phase of the inquiry indi-cated that it was difficult to do a computer-aided classi-fication of valleys based only on valley form. Conven-tional classification of the plateau’s valleys had also been done using stereoscopy to assist in the geomorphological interpretation. The results of these classifications were compared, and it was concluded that DEMs are useful in landscape analysis especially if combined with traditional geomorphological analysis.

text: Landform classification of the Mamaku Plateau using a digital elevation model. The Mamaku Plateau is a large, forest-covered ignimbrite plateau in the North Island of New Zealand. This study was launched to aid inquiries into the evolu-tion of the plateau by classifying its valleys (which con-stitute Mamaku’s main geomorphological feature).An automatic classification of the valley forms in the Mamaku Plateau was made using a Digital Elevation Model (DEM). A new algorithm was created for the Arc/Info Geographic Information System, to extract the valleys from the DEM. Preliminary results from this phase of the inquiry indi-cated that it was difficult to do a computer-aided classi-fication of valleys based only on valley form. Conven-tional classification of the plateau’s valleys had also been done using stereoscopy to assist in the geomorphological interpretation. The results of these classifications were compared, and it was concluded that DEMs are useful in landscape analysis especially if combined with traditional geomorphological analysis.

year: 1996

title: Mouri matters Contextualizing mouri in Māori health discourse

authors: Penehira, Mera

abstract: The vision statement of Te Reo o Taranaki, “Tuku reo, tuku mouri: language, culture, crossing generations”, embodies the essence of an understanding of mouri which goes beyond the simple dictionary translations of “life force” or “life essence”. Indeed, there are numerous oral narratives—whakataukī (proverbs), waiata (songs), haka (dance), karanga (ceremonial call), whaikōrero (formal speech), karakia (prayers and incantations)—from the present day to our earliest records of Māori history that engage the notion of mouri. The purpose of this paper is to examine current understandings of mouri and, by linking the concept with linguistic, cultural and intergenerational terms—as in the Taranaki example—it will be argued that mouri is something of significance to our “being” and to our wellbeing.

text: Mouri matters Contextualizing mouri in Māori health discourse The vision statement of Te Reo o Taranaki, “Tuku reo, tuku mouri: language, culture, crossing generations”, embodies the essence of an understanding of mouri which goes beyond the simple dictionary translations of “life force” or “life essence”. Indeed, there are numerous oral narratives—whakataukī (proverbs), waiata (songs), haka (dance), karanga (ceremonial call), whaikōrero (formal speech), karakia (prayers and incantations)—from the present day to our earliest records of Māori history that engage the notion of mouri. The purpose of this paper is to examine current understandings of mouri and, by linking the concept with linguistic, cultural and intergenerational terms—as in the Taranaki example—it will be argued that mouri is something of significance to our “being” and to our wellbeing.

year: 2011