title: Synthesis, characterization and biological activity of cycloaurated organogold(III) complexes with imidate ligands

authors: Kilpin, Kelly Joan

subjects: Gold complexes

abstract: The reactions of the cycloaurated gold(III) complexes (2-bp)AuCl2 (2-bp = 2-benzylpyridyl) or (damp)AuCl2 (damp = Me2NCH2C6H4) with an excess of sodium saccharinate (Nasacc), potassium phthalimidate (Kphth), or with isatin and trimethylamine in refluxing methanol results in the successful isolation of a series of new gold(III) imidate complexes. These were characterised by NMR and IR spectroscopies, and by X-ray structure determinations on (2-bp)Au(sacc)2 and (2-bp)Au(phth)2. In both structures, the planes of the saccharinate and the phthalimidate ligands are orientated almost perpendicular to the gold coordination plane. As expected from trans-influence considerations, the Au-N(imidate) bond lengths trans to the aryl carbon atoms are longer than the Au-N(imidate) bond lengths trans to the pyridyl groups. The complexes have also been characterised by electrospray ionisation MS; in the presence of halide ligands, one imidate ligand is readily displaced. Anti-tumour (P388 murine leukemia) and selected anti-microbial data for the new complexes are reported. Surprisingly, all three damp complexes had low anti-tumour activity, which is likely to be a consequence of the poor solubility of these complexes. The synthesis and characterisation of a related gold(III) bis(amidate) complex derived from sulfathiazole is also described.

text: Synthesis, characterization and biological activity of cycloaurated organogold(III) complexes with imidate ligands The reactions of the cycloaurated gold(III) complexes (2-bp)AuCl2 (2-bp = 2-benzylpyridyl) or (damp)AuCl2 (damp = Me2NCH2C6H4) with an excess of sodium saccharinate (Nasacc), potassium phthalimidate (Kphth), or with isatin and trimethylamine in refluxing methanol results in the successful isolation of a series of new gold(III) imidate complexes. These were characterised by NMR and IR spectroscopies, and by X-ray structure determinations on (2-bp)Au(sacc)2 and (2-bp)Au(phth)2. In both structures, the planes of the saccharinate and the phthalimidate ligands are orientated almost perpendicular to the gold coordination plane. As expected from trans-influence considerations, the Au-N(imidate) bond lengths trans to the aryl carbon atoms are longer than the Au-N(imidate) bond lengths trans to the pyridyl groups. The complexes have also been characterised by electrospray ionisation MS; in the presence of halide ligands, one imidate ligand is readily displaced. Anti-tumour (P388 murine leukemia) and selected anti-microbial data for the new complexes are reported. Surprisingly, all three damp complexes had low anti-tumour activity, which is likely to be a consequence of the poor solubility of these complexes. The synthesis and characterisation of a related gold(III) bis(amidate) complex derived from sulfathiazole is also described.

year: 2007-01-01

title: "But I still love him": Women talk about love and violence, and counsellors respond

authors: Snowdon, Jennifer Mary (Jenny)

subjects: Feminist new materialist research

abstract: This feminist research enacts a new materialist performance of theory/practice that investigates love-entangled-with-violence in intimate heterosexual partner relationship. The study investigates the double dilemma of a woman’s love-connectivity to her partner that refuses to be unfelt and unthought, despite the disturbance of violence, with the counselling conundrum of how to effectively and ethically respond. The data materials were generated in two cycles of group interviews. The initial waves of data were drawn from narratives told in interviews with women whose intimate partners had subjected them to physical abuses and coercive controls produced through accretions of surveillance, accusation and constraint. These narratives were haunted by intensities of love dis-join-ted. Consequently, the women engaged with counselling or therapeutic programmes. As researcher, I wanted to learn what women had to say about their experiences of therapy and to take these readings of therapy to a group of counsellors in collective documents. In a second wave of interviews, a group of counsellors offered practice accounts of justice-doing, cut together-apart with women’s struggle, refolded into ethical considerations for finding safety. In that sense, both the counsellors and women-in-danger traversed uncertain territory. Collaborative therapeutic practices, such as those the counsellor group described in this research, act as apparatuses for interference and contestibility, and hence, for change. 

The study’s originating questions were about how power/knowledge and domination (Foucault) is exercised in heterosexual partner relationship. The theoretical arc of the study took an early turn towards new materialisms (Barad) and the affective potentialities of human-nonhuman assemblages (Massumi). Entities such as vehicles, guns and a knife, queered the trajectory of the study towards differentiating encounters with the thing power of clusters of actants other than and including humans (Bennett). The analysis of the research materials emerges through a Baradian diffractive approach, which maps the effects of difference. Taking Barad’s proposal for the inseparability of matter-discourse, the study sometimes maps affecting moments for the researcher-self onto the theoretical positions of the thesis. The contributions of this thesis are for counselling practices that attend to matter⇔discourse, including other-than-human bodies. A new materialist iteration of narrative therapy, the culmination of this research work, offers shifts in conceptual accounts of affect, and how to address what matters. These differences-in-the-(re)making are themselves indeterminate and ongoing.

text: "But I still love him": Women talk about love and violence, and counsellors respond This feminist research enacts a new materialist performance of theory/practice that investigates love-entangled-with-violence in intimate heterosexual partner relationship. The study investigates the double dilemma of a woman’s love-connectivity to her partner that refuses to be unfelt and unthought, despite the disturbance of violence, with the counselling conundrum of how to effectively and ethically respond. The data materials were generated in two cycles of group interviews. The initial waves of data were drawn from narratives told in interviews with women whose intimate partners had subjected them to physical abuses and coercive controls produced through accretions of surveillance, accusation and constraint. These narratives were haunted by intensities of love dis-join-ted. Consequently, the women engaged with counselling or therapeutic programmes. As researcher, I wanted to learn what women had to say about their experiences of therapy and to take these readings of therapy to a group of counsellors in collective documents. In a second wave of interviews, a group of counsellors offered practice accounts of justice-doing, cut together-apart with women’s struggle, refolded into ethical considerations for finding safety. In that sense, both the counsellors and women-in-danger traversed uncertain territory. Collaborative therapeutic practices, such as those the counsellor group described in this research, act as apparatuses for interference and contestibility, and hence, for change. 

The study’s originating questions were about how power/knowledge and domination (Foucault) is exercised in heterosexual partner relationship. The theoretical arc of the study took an early turn towards new materialisms (Barad) and the affective potentialities of human-nonhuman assemblages (Massumi). Entities such as vehicles, guns and a knife, queered the trajectory of the study towards differentiating encounters with the thing power of clusters of actants other than and including humans (Bennett). The analysis of the research materials emerges through a Baradian diffractive approach, which maps the effects of difference. Taking Barad’s proposal for the inseparability of matter-discourse, the study sometimes maps affecting moments for the researcher-self onto the theoretical positions of the thesis. The contributions of this thesis are for counselling practices that attend to matter⇔discourse, including other-than-human bodies. A new materialist iteration of narrative therapy, the culmination of this research work, offers shifts in conceptual accounts of affect, and how to address what matters. These differences-in-the-(re)making are themselves indeterminate and ongoing.

year: 2021

title: From mainstream to manaaki: Indigenising our approach to immigration

authors: Kukutai, Tahu

abstract: In recent years, discontent with migration and migrants in the wealthy global north has manifested in disturbing ways: cue Brexit, xenophobia, border paranoia, far-right nationalism and its bedfellow white supremacy. On the surface, Aotearoa New Zealand appears to have escaped the uglier aspects of this nativism. Despite the grumblings of the New Zealand First Party, no serious popular or political anti-immigration movement has appeared, and racially motivated attacks against migrants are relatively rare. This is despite the fact that Aotearoa has a much higher relative foreign-born population share than the United States or United Kingdom,1 and ‘superdiverse’ Auckland – which comprises at least 40 per cent migrants – now has the ignominious claim to being the fourthleast affordable city in the world, far outstripping London and New York.

text: From mainstream to manaaki: Indigenising our approach to immigration In recent years, discontent with migration and migrants in the wealthy global north has manifested in disturbing ways: cue Brexit, xenophobia, border paranoia, far-right nationalism and its bedfellow white supremacy. On the surface, Aotearoa New Zealand appears to have escaped the uglier aspects of this nativism. Despite the grumblings of the New Zealand First Party, no serious popular or political anti-immigration movement has appeared, and racially motivated attacks against migrants are relatively rare. This is despite the fact that Aotearoa has a much higher relative foreign-born population share than the United States or United Kingdom,1 and ‘superdiverse’ Auckland – which comprises at least 40 per cent migrants – now has the ignominious claim to being the fourthleast affordable city in the world, far outstripping London and New York.

year: 2017