title: Developing a core outcome set for future infertility research: an international consensus development study

authors: Duffy, J.M.N.

subjects: Consensus development study

abstract: STUDY QUESTION: Can a core outcome set to standardize outcome selection, collection and reporting across future infertility research be developed? 
SUMMARY ANSWER: A minimum data set, known as a core outcome set, has been developed for randomized controlled trials (RCTs) and systematic reviews evaluating potential treatments for infertility. 
WHAT IS KNOWN ALREADY: Complex issues, including a failure to consider the perspectives of people with fertility problems when selecting outcomes, variations in outcome definitions and the selective reporting of outcomes on the basis of statistical analysis, make the results of infertility research difficult to interpret. 
STUDY DESIGN, SIZE, DURATION: A three-round Delphi survey (372 participants from 41 countries) and consensus development workshop (30 participants from 27 countries). PARTICIPANTS/MATERIALS, SETTING, METHODS: Healthcare professionals, researchers and people with fertility problems were brought together in an open and transparent process using formal consensus science methods. 
MAIN RESULTS AND THE ROLE OF CHANCE: The core outcome set consists of: viable intrauterine pregnancy confirmed by ultrasound (accounting for singleton, twin and higher multiple pregnancy); pregnancy loss (accounting for ectopic pregnancy, miscarriage, stillbirth and termination of pregnancy); live birth; gestational age at delivery; birthweight; neonatal mortality; and major congenital anomaly. Time to pregnancy leading to live birth should be reported when applicable. 
LIMITATIONS, REASONS FOR CAUTION: We used consensus development methods which have inherent limitations, including the representativeness of the participant sample, Delphi survey attrition and an arbitrary consensus threshold. 
WIDER IMPLICATIONS OF THE FINDINGS: Embedding the core outcome set within RCTs and systematic reviews should ensure the comprehensive selection, collection and reporting of core outcomes. Research funding bodies, the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) statement, and over 80 specialty journals, including the Cochrane Gynaecology and Fertility Group, Fertility and Sterility and Human Reproduction, have committed to implementing this core outcome set. 
STUDY FUNDING/COMPETING INTEREST(S): This research was funded by the Catalyst Fund, Royal Society of New Zealand, Auckland Medical Research Fund and Maurice and Phyllis Paykel Trust. The funder had no role in the design and conduct of the study, the collection, management, analysis or interpretation of data, or manuscript preparation. B.W.J.M. is supported by a National Health and Medical Research Council Practitioner Fellowship (GNT1082548). S.B. was supported by University of Auckland Foundation Seelye Travelling Fellowship. S.B. reports being the Editor-in-Chief of Human Reproduction Open and an editor of the Cochrane Gynaecology and Fertility group. J.L.H.E. reports being the Editor Emeritus of Human Reproduction. J.M.L.K. reports research sponsorship from Ferring and Theramex. R.S.L. reports consultancy fees from Abbvie, Bayer, Ferring, Fractyl, Insud Pharma and Kindex and research sponsorship from Guerbet and Hass Avocado Board. B.W.J.M. reports consultancy fees from Guerbet, iGenomix, Merck, Merck KGaA and ObsEva. C.N. reports being the Co Editor-in-Chief of Fertility and Sterility and Section Editor of the Journal of Urology, research sponsorship from Ferring, and retains a financial interest in NexHand. A.S. reports consultancy fees from Guerbet. E.H.Y.N. reports research sponsorship from Merck. N.L.V. reports consultancy and conference fees from Ferring, Merck and Merck Sharp and Dohme. The remaining authors declare no competing interests in relation to the work presented. All authors have completed the disclosure form. TRIAL REGISTRATION NUMBER: Core Outcome Measures in Effectiveness Trials Initiative: 1023.

text: Developing a core outcome set for future infertility research: an international consensus development study STUDY QUESTION: Can a core outcome set to standardize outcome selection, collection and reporting across future infertility research be developed? 
SUMMARY ANSWER: A minimum data set, known as a core outcome set, has been developed for randomized controlled trials (RCTs) and systematic reviews evaluating potential treatments for infertility. 
WHAT IS KNOWN ALREADY: Complex issues, including a failure to consider the perspectives of people with fertility problems when selecting outcomes, variations in outcome definitions and the selective reporting of outcomes on the basis of statistical analysis, make the results of infertility research difficult to interpret. 
STUDY DESIGN, SIZE, DURATION: A three-round Delphi survey (372 participants from 41 countries) and consensus development workshop (30 participants from 27 countries). PARTICIPANTS/MATERIALS, SETTING, METHODS: Healthcare professionals, researchers and people with fertility problems were brought together in an open and transparent process using formal consensus science methods. 
MAIN RESULTS AND THE ROLE OF CHANCE: The core outcome set consists of: viable intrauterine pregnancy confirmed by ultrasound (accounting for singleton, twin and higher multiple pregnancy); pregnancy loss (accounting for ectopic pregnancy, miscarriage, stillbirth and termination of pregnancy); live birth; gestational age at delivery; birthweight; neonatal mortality; and major congenital anomaly. Time to pregnancy leading to live birth should be reported when applicable. 
LIMITATIONS, REASONS FOR CAUTION: We used consensus development methods which have inherent limitations, including the representativeness of the participant sample, Delphi survey attrition and an arbitrary consensus threshold. 
WIDER IMPLICATIONS OF THE FINDINGS: Embedding the core outcome set within RCTs and systematic reviews should ensure the comprehensive selection, collection and reporting of core outcomes. Research funding bodies, the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) statement, and over 80 specialty journals, including the Cochrane Gynaecology and Fertility Group, Fertility and Sterility and Human Reproduction, have committed to implementing this core outcome set. 
STUDY FUNDING/COMPETING INTEREST(S): This research was funded by the Catalyst Fund, Royal Society of New Zealand, Auckland Medical Research Fund and Maurice and Phyllis Paykel Trust. The funder had no role in the design and conduct of the study, the collection, management, analysis or interpretation of data, or manuscript preparation. B.W.J.M. is supported by a National Health and Medical Research Council Practitioner Fellowship (GNT1082548). S.B. was supported by University of Auckland Foundation Seelye Travelling Fellowship. S.B. reports being the Editor-in-Chief of Human Reproduction Open and an editor of the Cochrane Gynaecology and Fertility group. J.L.H.E. reports being the Editor Emeritus of Human Reproduction. J.M.L.K. reports research sponsorship from Ferring and Theramex. R.S.L. reports consultancy fees from Abbvie, Bayer, Ferring, Fractyl, Insud Pharma and Kindex and research sponsorship from Guerbet and Hass Avocado Board. B.W.J.M. reports consultancy fees from Guerbet, iGenomix, Merck, Merck KGaA and ObsEva. C.N. reports being the Co Editor-in-Chief of Fertility and Sterility and Section Editor of the Journal of Urology, research sponsorship from Ferring, and retains a financial interest in NexHand. A.S. reports consultancy fees from Guerbet. E.H.Y.N. reports research sponsorship from Merck. N.L.V. reports consultancy and conference fees from Ferring, Merck and Merck Sharp and Dohme. The remaining authors declare no competing interests in relation to the work presented. All authors have completed the disclosure form. TRIAL REGISTRATION NUMBER: Core Outcome Measures in Effectiveness Trials Initiative: 1023.

year: 2020

title: On the Benefits of Non-Canonical Filtering in Publish/Subscribe Systems

authors: Bittner, Sven

subjects: computer science

abstract: Current matching approaches in pub/sub systems only allow conjunctive subscriptions. Arbitrary subscriptions have to be transformed into canonical expressions, e.g., DNFs, and need to be treated as several conjunctive subscriptions. This technique is known from database systems and allows us to apply more efficient filtering algorithms. Since pub/sub systems are the contrary to traditional database systems, it is questionable if filtering several canonical subscriptions is the most efficient and scalable way of dealing with arbitrary subscriptions. In this paper we show that our filtering approach supporting arbitrary Boolean subscriptions is more scalable and efficient than current matching algorithms requiring transformations of subscriptions into DNFs.

text: On the Benefits of Non-Canonical Filtering in Publish/Subscribe Systems Current matching approaches in pub/sub systems only allow conjunctive subscriptions. Arbitrary subscriptions have to be transformed into canonical expressions, e.g., DNFs, and need to be treated as several conjunctive subscriptions. This technique is known from database systems and allows us to apply more efficient filtering algorithms. Since pub/sub systems are the contrary to traditional database systems, it is questionable if filtering several canonical subscriptions is the most efficient and scalable way of dealing with arbitrary subscriptions. In this paper we show that our filtering approach supporting arbitrary Boolean subscriptions is more scalable and efficient than current matching algorithms requiring transformations of subscriptions into DNFs.

year: 2005

title: Hangarau me te Māori: Māori and technology

authors: Keegan, Te Taka Adrian Gregory

subjects: Māori

abstract: A sign of a vibrant, healthy developing nation is the adaptation and uptake of new technologies. Māori have a long, but mostly unrecognised, history of ingenious innovation and adaption of new technologies. This chapter will reveal Māori ingenuity through discussion of historic examples and modern media usages by Māori, and the future implications these have for Māori.
Technology can be defined as tools, devices and machines that have been developed by the application of scientific knowledge. Māori technology, then, is Māori tools, devices and machines that have been developed by the application of Māori scientific knowledge. This chapter discusses some examples of innovative Māori technology and their adoption in both historic and modern times. It includes sections on historic Māori technology, Māori media innovation and Māori adoption of Internet technology. Two sections are further expanded on: Māori in social networking sites and te reo Māori in technology. The chapter concludes with the authors' thoughts on how the adoption of new technologies will shape tikanga Māori and te reo Māori into the future.

text: Hangarau me te Māori: Māori and technology A sign of a vibrant, healthy developing nation is the adaptation and uptake of new technologies. Māori have a long, but mostly unrecognised, history of ingenious innovation and adaption of new technologies. This chapter will reveal Māori ingenuity through discussion of historic examples and modern media usages by Māori, and the future implications these have for Māori.
Technology can be defined as tools, devices and machines that have been developed by the application of scientific knowledge. Māori technology, then, is Māori tools, devices and machines that have been developed by the application of Māori scientific knowledge. This chapter discusses some examples of innovative Māori technology and their adoption in both historic and modern times. It includes sections on historic Māori technology, Māori media innovation and Māori adoption of Internet technology. Two sections are further expanded on: Māori in social networking sites and te reo Māori in technology. The chapter concludes with the authors' thoughts on how the adoption of new technologies will shape tikanga Māori and te reo Māori into the future.

year: 2018