title: Phage display systems for antibody engineering and evaluation

authors: Hanning, Kyrin Rene

subjects: Protein engineering

abstract: Antibodies are versatile effector molecules of the adaptive immune system, distinguished by their capacity to recognise and engage diverse antigens with high specificity and affinity. The widespread adoption of antibodies, and their various formats, in diagnostics and therapeutics has been made possible through the co-operation of experimental and computational molecular engineering techniques. Functional screening of variant antibody libraries has proven essential for successful antibody development. Several protein display technologies have been deployed for this important screening phase, including phage display. Whilst one of the older approaches, phage display still offers many advantages over alternatives and synergises well with other advances in molecular biology techniques. This thesis demonstrates how phage display, when paired with modern techniques in novel ways, remains an extremely flexible and powerful tool for engineering and evaluating antibodies.

text: Phage display systems for antibody engineering and evaluation Antibodies are versatile effector molecules of the adaptive immune system, distinguished by their capacity to recognise and engage diverse antigens with high specificity and affinity. The widespread adoption of antibodies, and their various formats, in diagnostics and therapeutics has been made possible through the co-operation of experimental and computational molecular engineering techniques. Functional screening of variant antibody libraries has proven essential for successful antibody development. Several protein display technologies have been deployed for this important screening phase, including phage display. Whilst one of the older approaches, phage display still offers many advantages over alternatives and synergises well with other advances in molecular biology techniques. This thesis demonstrates how phage display, when paired with modern techniques in novel ways, remains an extremely flexible and powerful tool for engineering and evaluating antibodies.

year: 2025

title: Adaptive Interfaces for Massively Multiplayer Online Games

authors: Deaker, Chris

subjects: HCI

abstract: Massively multi-player online role-playing games (MMORPGs), such as World of Warcraft, have become very popular in recent years. These types of games typically feature rich and complex game environments, enabling more engaging game-play experiences. However, the complexity of the underlying game systems can also result in increased interface complexity, which may diminish player enjoyment - a major element of players' game experience. Players may customise their in-game interfaces to deal with this type of complexity and hence improve their performance, but the challenges associated with manual interface customisation may prevent some players from effectively personalising their own game interface. 

Players' behavioural models can be used to provide a means of determining potential player in-game behaviour, thus allowing for the automatic adaptation of game interfaces to better suit player needs. This thesis aims to determine whether player-modelled adaptive interfaces can improve players' game experience in MMORPGs.

A survey of MMORPG players was conducted to determine which aspects of player experience may be impacted by interface modification. The findings of this study informed the development of an adaptive interface feedback system which aimed to provide players with relevant information, in order to improve their game experience. This prototype system was then evaluated, in order to determine the impact of the developed system on players' game experience.

text: Adaptive Interfaces for Massively Multiplayer Online Games Massively multi-player online role-playing games (MMORPGs), such as World of Warcraft, have become very popular in recent years. These types of games typically feature rich and complex game environments, enabling more engaging game-play experiences. However, the complexity of the underlying game systems can also result in increased interface complexity, which may diminish player enjoyment - a major element of players' game experience. Players may customise their in-game interfaces to deal with this type of complexity and hence improve their performance, but the challenges associated with manual interface customisation may prevent some players from effectively personalising their own game interface. 

Players' behavioural models can be used to provide a means of determining potential player in-game behaviour, thus allowing for the automatic adaptation of game interfaces to better suit player needs. This thesis aims to determine whether player-modelled adaptive interfaces can improve players' game experience in MMORPGs.

A survey of MMORPG players was conducted to determine which aspects of player experience may be impacted by interface modification. The findings of this study informed the development of an adaptive interface feedback system which aimed to provide players with relevant information, in order to improve their game experience. This prototype system was then evaluated, in order to determine the impact of the developed system on players' game experience.

year: 2013

title: The digital divide in New Zealand: The position of Maori and Pacific peoples

authors: Gibson, John

subjects: communication

abstract: Information and communication technology plays an ever-growing role in economic, political and social life and those who are unable to access such technologies are increasingly disadvantaged. Hence, what has come to be known as the 'digital divide' is of considerable significance. Here, indicators of that divide as it affects Maori and

text: The digital divide in New Zealand: The position of Maori and Pacific peoples Information and communication technology plays an ever-growing role in economic, political and social life and those who are unable to access such technologies are increasingly disadvantaged. Hence, what has come to be known as the 'digital divide' is of considerable significance. Here, indicators of that divide as it affects Maori and

year: 2002