title: Hantupeptins B and C, cytotoxic cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula

authors: Tripathi, Ashootosh

subjects: Lyngbya majuscule

abstract: Hantupeptins B (2) and C (3) were isolated, along with the previously reported hantupeptin A (1), from the marine cyanobacterium, Lyngbya majuscula, collected from Pulau Hantu Besar, Singapore. Their structures were elucidated by interpretation of extensive 1D and 2D NMR spectroscopic data. Compounds 2 and 3 are cyclic depsipeptides consisting of five α-amino/hydroxy acid residues, including phenyllactic acid, proline, N-methyl-valine, valine, N-methyl-isoleucine, and a β-hydroxy acid unit with different degrees of unsaturation at the terminal end of each molecule. The absolute configurations of the common amino acids and phenyllactic acid were determined by the advanced Marfey’s and chiral HPLC analyses, respectively. The complete stereochemistry of 3-hydroxy-2-methyl-7-octynoic acid moiety in hantupeptin A was elucidated by a combination of homonuclear J-resolved 2D NMR experiments and by Mosher’s method. Hantupeptins B and C showed moderate in vitro cytotoxicity when tested against MOLT-4 (leukemic) and MCF-7 (breast cancer) cell lines.

text: Hantupeptins B and C, cytotoxic cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula Hantupeptins B (2) and C (3) were isolated, along with the previously reported hantupeptin A (1), from the marine cyanobacterium, Lyngbya majuscula, collected from Pulau Hantu Besar, Singapore. Their structures were elucidated by interpretation of extensive 1D and 2D NMR spectroscopic data. Compounds 2 and 3 are cyclic depsipeptides consisting of five α-amino/hydroxy acid residues, including phenyllactic acid, proline, N-methyl-valine, valine, N-methyl-isoleucine, and a β-hydroxy acid unit with different degrees of unsaturation at the terminal end of each molecule. The absolute configurations of the common amino acids and phenyllactic acid were determined by the advanced Marfey’s and chiral HPLC analyses, respectively. The complete stereochemistry of 3-hydroxy-2-methyl-7-octynoic acid moiety in hantupeptin A was elucidated by a combination of homonuclear J-resolved 2D NMR experiments and by Mosher’s method. Hantupeptins B and C showed moderate in vitro cytotoxicity when tested against MOLT-4 (leukemic) and MCF-7 (breast cancer) cell lines.

year: 2010-02

title: Beginning the day with the IWB in an early childhood classroom

authors: Harlow, Ann

subjects: interactive whiteboard

abstract: There is a substantial demand in New Zealand for professional learning opportunities to help early years’ teachers to make use of ICT for teaching and learning (Harlow, Cowie and Jones, 2008), and where interactive whiteboards (IWBs) are increasingly being purchased by schools as instructional technologies. This paper reports on the findings of a researcher who was invited by a teacher in a small rural school in New Zealand to describe and understand the use of an IWB with young children aged five to six years. In this paper, the role of the IWB to enhance learning particularly in the use of language, symbols and texts is examined. The research involved collecting data from intensive classroom observation over a week using video and audio recordings as well as student and teacher interviews. Data were analysed using a framework developed by Kennewell and Beauchamp (2007), who identified how teachers used features of ICT/IWBs to enhance learning. The findings indicate that it was the way the teacher integrated the IWB into her pedagogy to improve the learning activities that made the IWB such an effective tool in this classroom.

text: Beginning the day with the IWB in an early childhood classroom There is a substantial demand in New Zealand for professional learning opportunities to help early years’ teachers to make use of ICT for teaching and learning (Harlow, Cowie and Jones, 2008), and where interactive whiteboards (IWBs) are increasingly being purchased by schools as instructional technologies. This paper reports on the findings of a researcher who was invited by a teacher in a small rural school in New Zealand to describe and understand the use of an IWB with young children aged five to six years. In this paper, the role of the IWB to enhance learning particularly in the use of language, symbols and texts is examined. The research involved collecting data from intensive classroom observation over a week using video and audio recordings as well as student and teacher interviews. Data were analysed using a framework developed by Kennewell and Beauchamp (2007), who identified how teachers used features of ICT/IWBs to enhance learning. The findings indicate that it was the way the teacher integrated the IWB into her pedagogy to improve the learning activities that made the IWB such an effective tool in this classroom.

year: 2010

title: Ngā Ara Auaha  - Creative practice student showcase

authors: Hill, Rodrigo

abstract: Ngā Ara Auaha simply translated means 'creative pathways' and comprises a collective exhibition featuring creative works from last year's undergraduate and postgraduate students across the University and working with creative practice research and outputs.

Ngā Ara Auaha is an annual student showcase, exhibiting the creative works of University of Waikato students (both undergraduate and postgraduate). The exhibition’s title refers to the ‘creative pathways’ taken by these students who have drawn on their own various creative practices, modes, and methods to think through their respective research journeys.

The call for submissions was open to students across all faculties and divisions of the University and as such the variety of works is vast. Multiple artistic mediums are featured in the same space, including photography and film, toi Māori, augmented media, fine art, design, and creative writing.

This exhibition showcases both the artistic skill of our students and the potential of creative methodologies in research. Expanding the rigid boundaries of the academy and blurring the lines between the ‘creative and critical’, with contributors adding to an established legacy of creative practice at the University of Waikato.

text: Ngā Ara Auaha  - Creative practice student showcase Ngā Ara Auaha simply translated means 'creative pathways' and comprises a collective exhibition featuring creative works from last year's undergraduate and postgraduate students across the University and working with creative practice research and outputs.

Ngā Ara Auaha is an annual student showcase, exhibiting the creative works of University of Waikato students (both undergraduate and postgraduate). The exhibition’s title refers to the ‘creative pathways’ taken by these students who have drawn on their own various creative practices, modes, and methods to think through their respective research journeys.

The call for submissions was open to students across all faculties and divisions of the University and as such the variety of works is vast. Multiple artistic mediums are featured in the same space, including photography and film, toi Māori, augmented media, fine art, design, and creative writing.

This exhibition showcases both the artistic skill of our students and the potential of creative methodologies in research. Expanding the rigid boundaries of the academy and blurring the lines between the ‘creative and critical’, with contributors adding to an established legacy of creative practice at the University of Waikato.

year: 2024