title: Enzyme activity and flexibility at very low hydration

authors: Kurkal, Vandana

abstract: Recent measurements have demonstrated enzyme activity at hydrations as low as 3%. This raises the question of whether hydration-induced enzyme flexibility is important for activity. Here, to address this, picosecond dynamic neutron scattering experiments are performed on pig liver esterase powders at 0%, 3%, 12%, and 50% hydration by weight and at temperatures ranging from 120 to 300 K. At all temperatures and hydrations, significant quasielastic scattering intensity is found in the protein, indicating the presence of anharmonic, diffusive motion. As the hydration increases, a temperature-dependent dynamical transition appears and strengthens involving additional diffusive motion. The implication of these results is that, although the additional hydration-induced diffusive motion in the protein detected here may be related to increased activity, it is not required for the enzyme to function.

text: Enzyme activity and flexibility at very low hydration Recent measurements have demonstrated enzyme activity at hydrations as low as 3%. This raises the question of whether hydration-induced enzyme flexibility is important for activity. Here, to address this, picosecond dynamic neutron scattering experiments are performed on pig liver esterase powders at 0%, 3%, 12%, and 50% hydration by weight and at temperatures ranging from 120 to 300 K. At all temperatures and hydrations, significant quasielastic scattering intensity is found in the protein, indicating the presence of anharmonic, diffusive motion. As the hydration increases, a temperature-dependent dynamical transition appears and strengthens involving additional diffusive motion. The implication of these results is that, although the additional hydration-induced diffusive motion in the protein detected here may be related to increased activity, it is not required for the enzyme to function.

year: 2005-05

title: Lie theory and separation of variables. 6. The equation iUt + ∆2U = 0

authors: Boyer, C.P.

subjects: Mathematics

abstract: This paper constitutes a detailed study of the nine−parameter symmetry group of the time−dependent free particle Schrödinger equation in two space dimensions. It is shown that this equation separates in exactly 26 coordinate systems and that each system corresponds to an orbit consisting of a commuting pair of first− and second−order symmetry operators. The study yields a unified treatment of the (attractive and repulsive) harmonic oscillator, linear potential and free particle Hamiltonians in a time−dependent formalism. Use of representation theory for the symmetry group permits simple derivations of addition and expansion theorems relating various solutions of the Schrödinger equation, many of which are new.

text: Lie theory and separation of variables. 6. The equation iUt + ∆2U = 0 This paper constitutes a detailed study of the nine−parameter symmetry group of the time−dependent free particle Schrödinger equation in two space dimensions. It is shown that this equation separates in exactly 26 coordinate systems and that each system corresponds to an orbit consisting of a commuting pair of first− and second−order symmetry operators. The study yields a unified treatment of the (attractive and repulsive) harmonic oscillator, linear potential and free particle Hamiltonians in a time−dependent formalism. Use of representation theory for the symmetry group permits simple derivations of addition and expansion theorems relating various solutions of the Schrödinger equation, many of which are new.

year: 1975-03

title: Understanding Māori rights and interests in intellectual property arising from research and innovation

authors: Sterling, Rogena

abstract: In the era of big data, the significance of data as a raw material for production and a source of societal and economic value has grown immensely. Advances in data mining, analytics, computing power, and storage capacity have facilitated broader access and utilization of big data for corporate and governmental purposes. This surge aligns with the knowledge economy, emphasizing knowledge-intensive activities to drive economic growth, a focus underscored in the latest Government Strategy.

However, as the knowledge economy expands, concerns arise about equity, Treaty partnerships, and the need to address issues of Māori data sovereignty and Indigenous data sovereignty. Discussions around Māori data sovereignty emphasize the importance of Māori control over various forms of Māori data, such as Mātauranga Māori, taonga species, and administrative data. Organizations like Te Mana Raraunga have been instrumental in developing principles and audit tools to support Māori data sovereignty.

Amidst these developments, questions have surfaced about the protection of Māori intellectual property (IP) within Aotearoa New Zealand, particularly outlined in the WAI262 report. This report, funded by Genomics Aotearoa and the National Science Challenge Science for Technological Innovation, aims to address these concerns. The project includes a literature review examining national legislation and international agreements constituting New Zealand's Intellectual Property Rights regime. This review explores how these frameworks safeguard Māori IP rights concerning Māori data, genomic data, and Mātauranga Māori. The second component involves a survey targeting research institutions to assess the presence of IP policies protecting Māori data in research and innovation processes.

The report provides a concise summary of the literature review and survey findings, with the overarching goal of assisting institutions in developing policies that safeguard Māori rights over their knowledge and data. The objective is to ensure equitable benefit-sharing throughout the innovation processes and address the evolving landscape of data sovereignty.

text: Understanding Māori rights and interests in intellectual property arising from research and innovation In the era of big data, the significance of data as a raw material for production and a source of societal and economic value has grown immensely. Advances in data mining, analytics, computing power, and storage capacity have facilitated broader access and utilization of big data for corporate and governmental purposes. This surge aligns with the knowledge economy, emphasizing knowledge-intensive activities to drive economic growth, a focus underscored in the latest Government Strategy.

However, as the knowledge economy expands, concerns arise about equity, Treaty partnerships, and the need to address issues of Māori data sovereignty and Indigenous data sovereignty. Discussions around Māori data sovereignty emphasize the importance of Māori control over various forms of Māori data, such as Mātauranga Māori, taonga species, and administrative data. Organizations like Te Mana Raraunga have been instrumental in developing principles and audit tools to support Māori data sovereignty.

Amidst these developments, questions have surfaced about the protection of Māori intellectual property (IP) within Aotearoa New Zealand, particularly outlined in the WAI262 report. This report, funded by Genomics Aotearoa and the National Science Challenge Science for Technological Innovation, aims to address these concerns. The project includes a literature review examining national legislation and international agreements constituting New Zealand's Intellectual Property Rights regime. This review explores how these frameworks safeguard Māori IP rights concerning Māori data, genomic data, and Mātauranga Māori. The second component involves a survey targeting research institutions to assess the presence of IP policies protecting Māori data in research and innovation processes.

The report provides a concise summary of the literature review and survey findings, with the overarching goal of assisting institutions in developing policies that safeguard Māori rights over their knowledge and data. The objective is to ensure equitable benefit-sharing throughout the innovation processes and address the evolving landscape of data sovereignty.

year: 2021-05