title: Enzyme activity and dynamics: xylanase activity in the absence of fast anharmonic dynamics

authors: Dunn, Rachel V.

subjects: cryoenzymology

abstract: The activity and dynamics of a simple, single subunit enzyme, the xylanase from Thermotoga maritima strain Fj SS3B.1 have been measured under similar conditions, from -70 to +10 °C. The internal motions of the enzyme, as evidenced by neutron scattering, undergo a sharp transition within this temperature range; they show no evidence for picosecond-timescale anharmonic behaviour (e.g. local diffusive motions or jumps between alternative conformations) at temperatures below -50 °C, whereas these motions are strongly activated at higher temperatures. The activity follows Arrhenius behaviour over the whole of the temperature range investigated, -70 to +10 °C. The results indicate that a temperature range exists over which the enzyme rate-limiting step is independent of fast anharmonic dynamics.

text: Enzyme activity and dynamics: xylanase activity in the absence of fast anharmonic dynamics The activity and dynamics of a simple, single subunit enzyme, the xylanase from Thermotoga maritima strain Fj SS3B.1 have been measured under similar conditions, from -70 to +10 °C. The internal motions of the enzyme, as evidenced by neutron scattering, undergo a sharp transition within this temperature range; they show no evidence for picosecond-timescale anharmonic behaviour (e.g. local diffusive motions or jumps between alternative conformations) at temperatures below -50 °C, whereas these motions are strongly activated at higher temperatures. The activity follows Arrhenius behaviour over the whole of the temperature range investigated, -70 to +10 °C. The results indicate that a temperature range exists over which the enzyme rate-limiting step is independent of fast anharmonic dynamics.

year: 2000

title: History in multimodal gameplay: A new language and model for constructing, experiencing, and studying the past

authors: Redder, Ben Dorrington

subjects: Historical Games

abstract: This doctoral study examines how historical gameplay constructs and provides ways of experiencing history within (historical) video games. Historical gameplay is examined and defined as an expression of history within historical games as it is the primary medium of representing or experiencing the past based on the interactions between the player and the various intricacies and components of the historical game. This thesis identifies, interprets, and illustrates several modalities of histories that emerge from and are characterised by particular modes and sequences of gameplay, with the aim of discerning and demonstrating what kind of experiences and knowledge of history are being conveyed. The undertaking of gameplay research in this thesis produced case studies of two contemporary Medieval games: A Plague Tale: Innocence (Asobo Studio, 2019) and Kingdom Come: Deliverance (Warhorse Studios, 2018). These texts were analysed via recorded footage of the author’s gameplay activity, while in-person interviews with several members of the game studios responsible for developing both these historical games provided insights into the research and game development processes required to produce historical games. In spite of the growing recognition of, and scholarship on historical video games, there are no current works from the discipline of history that thoroughly explore gameplay as a different yet innovative medium for disseminating and understanding history. This thesis fills that gap. Studying gameplay from the development and release of recent Medieval historical games has the potential to provide historians with new insights and opportunities regarding gameplay as catalysts for studying, discussing, and critiquing history.

text: History in multimodal gameplay: A new language and model for constructing, experiencing, and studying the past This doctoral study examines how historical gameplay constructs and provides ways of experiencing history within (historical) video games. Historical gameplay is examined and defined as an expression of history within historical games as it is the primary medium of representing or experiencing the past based on the interactions between the player and the various intricacies and components of the historical game. This thesis identifies, interprets, and illustrates several modalities of histories that emerge from and are characterised by particular modes and sequences of gameplay, with the aim of discerning and demonstrating what kind of experiences and knowledge of history are being conveyed. The undertaking of gameplay research in this thesis produced case studies of two contemporary Medieval games: A Plague Tale: Innocence (Asobo Studio, 2019) and Kingdom Come: Deliverance (Warhorse Studios, 2018). These texts were analysed via recorded footage of the author’s gameplay activity, while in-person interviews with several members of the game studios responsible for developing both these historical games provided insights into the research and game development processes required to produce historical games. In spite of the growing recognition of, and scholarship on historical video games, there are no current works from the discipline of history that thoroughly explore gameplay as a different yet innovative medium for disseminating and understanding history. This thesis fills that gap. Studying gameplay from the development and release of recent Medieval historical games has the potential to provide historians with new insights and opportunities regarding gameplay as catalysts for studying, discussing, and critiquing history.

year: 2022

title: Te hau mihi ata mātauranga Māori and science - Cross cultural dialogue

authors: Joseph, Robert

abstract: The Te Hau Mihi Ata Mātauranga Māori and Science research project (the research project) will explore ways to link mātauranga Māori and western science. The purpose of the research project is to open a new creative knowledge space to unleash innovative thinking and cross-cultural connection that is unique to New Zealand which can be a source of untapped economic, social, environmental and cultural potential. The historic marginalisation of alternative value and knowledge systems has prevented quality engagement and dialogue between these two knowledge systems in New Zealand. The research project will develop, inter alia, a new inter-cultural dialogue process between Māori educated in western-based science and experts in mātauranga Māori.

text: Te hau mihi ata mātauranga Māori and science - Cross cultural dialogue The Te Hau Mihi Ata Mātauranga Māori and Science research project (the research project) will explore ways to link mātauranga Māori and western science. The purpose of the research project is to open a new creative knowledge space to unleash innovative thinking and cross-cultural connection that is unique to New Zealand which can be a source of untapped economic, social, environmental and cultural potential. The historic marginalisation of alternative value and knowledge systems has prevented quality engagement and dialogue between these two knowledge systems in New Zealand. The research project will develop, inter alia, a new inter-cultural dialogue process between Māori educated in western-based science and experts in mātauranga Māori.

year: 2008-11