title: Case Comment: Re Greenpeace of New Zealand Inc

authors: Chevalier-Watts, Juliet

abstract: This has been a much awaited decision and marks the end of a long journey with regard to matters relating to political activities and charitable trusts, as well as considering illegal activities and charitable purpose. For a charity to be recognised as charitable at law in New Zealand, and thus take advantage of the fiscal and social benefits of this recognition, an entity must apply to the Department of Internal Affairs – Charities1 to register as charity. An entity must demonstrate that it falls under one of the four heads of charity, which find their history in the seminal case of The Commissioners for Special Purposes of the Income Tax v Pemsel2 and now s 5(1) of the Charities Act 2005, which states: 
“In this Act, unless the context otherwise requires, charitable purpose includes every charitable purpose, whether it relates to the relief of poverty, the advancement of education or religion, or any other matter beneficial to the community”

text: Case Comment: Re Greenpeace of New Zealand Inc This has been a much awaited decision and marks the end of a long journey with regard to matters relating to political activities and charitable trusts, as well as considering illegal activities and charitable purpose. For a charity to be recognised as charitable at law in New Zealand, and thus take advantage of the fiscal and social benefits of this recognition, an entity must apply to the Department of Internal Affairs – Charities1 to register as charity. An entity must demonstrate that it falls under one of the four heads of charity, which find their history in the seminal case of The Commissioners for Special Purposes of the Income Tax v Pemsel2 and now s 5(1) of the Charities Act 2005, which states: 
“In this Act, unless the context otherwise requires, charitable purpose includes every charitable purpose, whether it relates to the relief of poverty, the advancement of education or religion, or any other matter beneficial to the community”

year: 2014

title: Biosensing-by-Learning Direct Targeting Strategy for Enhanced Tumor Sensitization

authors: Chen, Yifan

subjects: Science & Technology

abstract: We propose a novel iterative-optimization-inspired direct targeting strategy (DTS) for smart nanosystems, which harness swarms of externally manipulable nanoswimmers assembled by magnetic nanoparticles (MNPs) for knowledge-aided tumor sensitization and targeting. We aim to demonstrate through computational experiments that the proposed DTS can significantly enhance the accumulation of MNPs in the tumor site, which serve as a contrast agent in various medical imaging modalities, by using the shortest possible physiological routes and with minimal systemic exposure. The epicenter of a tumor corresponds to the global maximum of an externally measurable objective function associated with an in vivo tumor-triggered biological gradient; the domain of the objective function is the tissue region at a high risk of malignancy; swarms of externally controllable magnetic nanoswimmers for tumor sensitization are modeled as the guess inputs. The objective function may be resulted from a passive phenomenon such as reduced blood flow or increased kurtosis of microvasculature due to tumor angiogenesis; otherwise, the objective function may involve an active phenomenon such as the fibrin formed during the coagulation cascade activated by tumor-targeted “activator” nanoparticles. Subsequently, the DTS can be interpreted from the iterative optimization perspective: guess inputs (i.e., swarms of nanoswimmers) are continuously updated according to the gradient of the objective function in order to find the optimum (i.e., tumor) by moving through the domain (i.e., tissue under screening). Along this line of thought, we propose the computational model based on the gradient descent (GD) iterative method to describe the GD-inspired DTS, which takes into account the realistic in vivo propagation scenario of nanoswimmers. By means of computational experiments, we show that the GD-inspired DTS yields higher probabilities of tumor sensitization and more significant dose accumulation compared to the “brute-force” search, which corresponds to the systemic targeting scenario where drug nanoparticles attempt to target a tumor by enumerating all possible pathways in the complex vascular network. The knowledge-aided DTS has potential to enhance the tumor sensitization and targeting performance remarkably by exploiting the externally measurable, tumor-triggered biological gradients. We believe that this work motivates a novel biosensing-by-learning framework facilitated by externally manipulable, smart nanosystems.

text: Biosensing-by-Learning Direct Targeting Strategy for Enhanced Tumor Sensitization We propose a novel iterative-optimization-inspired direct targeting strategy (DTS) for smart nanosystems, which harness swarms of externally manipulable nanoswimmers assembled by magnetic nanoparticles (MNPs) for knowledge-aided tumor sensitization and targeting. We aim to demonstrate through computational experiments that the proposed DTS can significantly enhance the accumulation of MNPs in the tumor site, which serve as a contrast agent in various medical imaging modalities, by using the shortest possible physiological routes and with minimal systemic exposure. The epicenter of a tumor corresponds to the global maximum of an externally measurable objective function associated with an in vivo tumor-triggered biological gradient; the domain of the objective function is the tissue region at a high risk of malignancy; swarms of externally controllable magnetic nanoswimmers for tumor sensitization are modeled as the guess inputs. The objective function may be resulted from a passive phenomenon such as reduced blood flow or increased kurtosis of microvasculature due to tumor angiogenesis; otherwise, the objective function may involve an active phenomenon such as the fibrin formed during the coagulation cascade activated by tumor-targeted “activator” nanoparticles. Subsequently, the DTS can be interpreted from the iterative optimization perspective: guess inputs (i.e., swarms of nanoswimmers) are continuously updated according to the gradient of the objective function in order to find the optimum (i.e., tumor) by moving through the domain (i.e., tissue under screening). Along this line of thought, we propose the computational model based on the gradient descent (GD) iterative method to describe the GD-inspired DTS, which takes into account the realistic in vivo propagation scenario of nanoswimmers. By means of computational experiments, we show that the GD-inspired DTS yields higher probabilities of tumor sensitization and more significant dose accumulation compared to the “brute-force” search, which corresponds to the systemic targeting scenario where drug nanoparticles attempt to target a tumor by enumerating all possible pathways in the complex vascular network. The knowledge-aided DTS has potential to enhance the tumor sensitization and targeting performance remarkably by exploiting the externally measurable, tumor-triggered biological gradients. We believe that this work motivates a novel biosensing-by-learning framework facilitated by externally manipulable, smart nanosystems.

year: 2019

title: Pūrākau, death, and assisted dying: A Māori framework for understanding end-of-life

authors: Karaka-Clarke, Te Hurinui

subjects: Pūrākau, Assisted Dying, Tikanga Māori, Mōair Cosmology, End of Life: Ethics, Mana Motuhake, Wairua, Whakapapa, Relational Autonomy

abstract: This conceptual article addresses several critical gaps in health literature by exploring the ethical, spiritual, and cultural dimensions of assisted dying through the lens of Tikanga Māori and pūrākau (ancestral narratives).  While existing end-of-life policy frameworks often prioritize Western bioethical principles, this article argues for the inclusion of Kaupapa Māori principles such as whakapapa, wairua, mana motuhake, and tapu/ noa as essential components of culturally resonant care.    Drawing upon foundational narratives including the separation of  Ranginui and Papatūānuku, the creation of Hineahuone, the transformation of Hinetītama into Hinenuitepō, and the fatal attempt of Māui to conquer death, we position pūrākau as dynamic ethical texts that guide decision-making.  This article contributes to Indigenous health discourse by offering a whānau-centred, tikanga-informed critique of the End-of-Life Choice Act 2019 and calls for broader recognition of spiritual and relational dimensions in end-of-life care.   We contend that, when under-taken with whānau engagement, spiritual awareness, and cultural integrity, may be ethically compatible with tikanga Māori

text: Pūrākau, death, and assisted dying: A Māori framework for understanding end-of-life This conceptual article addresses several critical gaps in health literature by exploring the ethical, spiritual, and cultural dimensions of assisted dying through the lens of Tikanga Māori and pūrākau (ancestral narratives).  While existing end-of-life policy frameworks often prioritize Western bioethical principles, this article argues for the inclusion of Kaupapa Māori principles such as whakapapa, wairua, mana motuhake, and tapu/ noa as essential components of culturally resonant care.    Drawing upon foundational narratives including the separation of  Ranginui and Papatūānuku, the creation of Hineahuone, the transformation of Hinetītama into Hinenuitepō, and the fatal attempt of Māui to conquer death, we position pūrākau as dynamic ethical texts that guide decision-making.  This article contributes to Indigenous health discourse by offering a whānau-centred, tikanga-informed critique of the End-of-Life Choice Act 2019 and calls for broader recognition of spiritual and relational dimensions in end-of-life care.   We contend that, when under-taken with whānau engagement, spiritual awareness, and cultural integrity, may be ethically compatible with tikanga Māori

year: 2025-09-24