title: Ethical relationships between science and society: Understanding the social responsibility of scientists

authors: Small, Bruce Harris

subjects: Ethics

abstract: The wider social responsibility of scientists has received theoretical discussion but little previous empirical research. To elucidate the construct, this thesis investigated scientists’ attitudes, values and beliefs about social responsibility, with a focus on Promethean gene technologies. The thesis articulates a framework for the construct domain and develops and validates a set of new measures related to scientific social responsibility. Five technology fuelled, social and ecological, existential threats to Earth are identified, establishing the need for an increased ethic of social responsibility for the scientific endeavour and scientists in an age of Promethean technologies. The power of developing gene technologies and their social and moral implications are examined, followed by a discussion of relevant normative, meta-ethical and applied ethics theories. Next, Kohlberg’s (1969) cognitive moral development theory, Rest’s (1979) theory of moral behaviour, and Schwartz’s (1992) theory of personal value orientation are discussed as a psychological context for scientific social responsibility. The few empirical studies addressing the issue are reviewed. Original empirical contributions are presented in two studies. Study 1 is an explorative, qualitative research project using face-to-face, in-depth, unstructured interviews to investigate a purposive sample of scientists’ (N = 22) beliefs about the social role of science, and scientists, in research and technology development. The participants all worked in the field of genetic engineering, or studied its social or ecological impacts. From a data-driven, manifest, thematic analysis, three themes emerged, each with several sub-themes: doing public good (sub-themes: benefit/harm, knowledge, technologies, and foresight); engagement (sub-themes: informing society, becoming informed, and integrity) and; compliance (sub-themes: scientific norms, business norms, laws and regulations, societal mores, and personal values). A theoretically-driven, latent, thematic analysis, examined the normative and meta-ethical reasoning underlying participants’ manifest positions. Evidence was found for normative ethical reasoning (i.e., deontological, teleological and virtue ethics) and a range of meta-ethical approaches (i.e., ethical relativism, conventionalism, objectivism, moral absolutism, subjectivism, emotivism, and cultural relativism). From Study 1 items were proposed for two measures of social responsibility based on the first two stages of Rest’s model of moral behaviour. Study 2, a quantitative survey of scientists from six New Zealand Crown Research Institutes (N = 733, 40.9% female), used a nomological network of 39 hypothesised directional relationships (correlations) to help infer construct validity to five new instruments related to social responsibility: moral awareness, moral judgement regarding personal behaviour, technological optimism, attitude to the commercialisation of science, and attitude to the democratisation of science. Five existing instruments also comprised the nomological network: the four Schwartz higher-order value dimensions and a concurrent criterion, general attitude to genetic engineering. Exploratory factor analysis was used to select items for single factor instruments and confirmatory factor analysis to purify the instruments’ dimensionality, followed by reliability analyses. Four new instruments demonstrated good psychometric properties. Twenty-seven of 39 hypothesised correlations were significant in the right direction (at the Bonferroni adjusted p < .001 level), providing initial support for the new instruments’ construct validities and study results regarding participants’ attitudes, beliefs and values towards conducting socially responsible Promethean science.

text: Ethical relationships between science and society: Understanding the social responsibility of scientists The wider social responsibility of scientists has received theoretical discussion but little previous empirical research. To elucidate the construct, this thesis investigated scientists’ attitudes, values and beliefs about social responsibility, with a focus on Promethean gene technologies. The thesis articulates a framework for the construct domain and develops and validates a set of new measures related to scientific social responsibility. Five technology fuelled, social and ecological, existential threats to Earth are identified, establishing the need for an increased ethic of social responsibility for the scientific endeavour and scientists in an age of Promethean technologies. The power of developing gene technologies and their social and moral implications are examined, followed by a discussion of relevant normative, meta-ethical and applied ethics theories. Next, Kohlberg’s (1969) cognitive moral development theory, Rest’s (1979) theory of moral behaviour, and Schwartz’s (1992) theory of personal value orientation are discussed as a psychological context for scientific social responsibility. The few empirical studies addressing the issue are reviewed. Original empirical contributions are presented in two studies. Study 1 is an explorative, qualitative research project using face-to-face, in-depth, unstructured interviews to investigate a purposive sample of scientists’ (N = 22) beliefs about the social role of science, and scientists, in research and technology development. The participants all worked in the field of genetic engineering, or studied its social or ecological impacts. From a data-driven, manifest, thematic analysis, three themes emerged, each with several sub-themes: doing public good (sub-themes: benefit/harm, knowledge, technologies, and foresight); engagement (sub-themes: informing society, becoming informed, and integrity) and; compliance (sub-themes: scientific norms, business norms, laws and regulations, societal mores, and personal values). A theoretically-driven, latent, thematic analysis, examined the normative and meta-ethical reasoning underlying participants’ manifest positions. Evidence was found for normative ethical reasoning (i.e., deontological, teleological and virtue ethics) and a range of meta-ethical approaches (i.e., ethical relativism, conventionalism, objectivism, moral absolutism, subjectivism, emotivism, and cultural relativism). From Study 1 items were proposed for two measures of social responsibility based on the first two stages of Rest’s model of moral behaviour. Study 2, a quantitative survey of scientists from six New Zealand Crown Research Institutes (N = 733, 40.9% female), used a nomological network of 39 hypothesised directional relationships (correlations) to help infer construct validity to five new instruments related to social responsibility: moral awareness, moral judgement regarding personal behaviour, technological optimism, attitude to the commercialisation of science, and attitude to the democratisation of science. Five existing instruments also comprised the nomological network: the four Schwartz higher-order value dimensions and a concurrent criterion, general attitude to genetic engineering. Exploratory factor analysis was used to select items for single factor instruments and confirmatory factor analysis to purify the instruments’ dimensionality, followed by reliability analyses. Four new instruments demonstrated good psychometric properties. Twenty-seven of 39 hypothesised correlations were significant in the right direction (at the Bonferroni adjusted p < .001 level), providing initial support for the new instruments’ construct validities and study results regarding participants’ attitudes, beliefs and values towards conducting socially responsible Promethean science.

year: 2011

title: Identification, cloning, and functional characterization of the IL-1 receptor antagonist in the chicken reveal important differences between the Chicken and mammals

authors: Gibson, Mark S.

subjects: gene

abstract: The human IL-1 family contains 11 genes encoded at three separate loci. Nine, including IL-1R antagonist (IL-1RN), are present at a single locus on chromosome 2, whereas IL-18 and IL-33 lie on chromosomes 11 and 9, respectively. There are currently only two known orthologs in the chicken, IL-1β and IL-18, which are encoded on chromosomes 22 and 24, respectively. Two novel chicken IL-1 family sequences were identified from expressed sequence tag libraries, representing secretory and intracellular (icIL-1RN) structural variants of the IL-1RN gene, as seen in mammals. Two further putative splice variants (SVs) of both chicken IL-1RN (chIL-1RN) structural variants were also isolated. Alternative splicing of human icIL-1RN gives three different transcripts; there are no known SVs for human secretory IL-1RN. The chicken icIL-1RN SVs differ from those found in human icIL-1RN in terms of the rearrangements involved. In mammals, IL-1RN inhibits IL-1 activity by physically occupying the IL-1 type I receptor. Both full-length structural variants of chIL-1RN exhibited biological activity similar to their mammalian orthologs in a macrophage cell line bioassay. The four SVs, however, were not biologically active. The chicken IL-1 family is more fragmented in the genome than those of mammals, particularly in that the large multigene locus seen in mammals is absent. This suggests differential evolution of the family since the divergence of birds and mammals from a common ancestor, and makes determination of the full repertoire of chicken IL-1 family members more challenging.

text: Identification, cloning, and functional characterization of the IL-1 receptor antagonist in the chicken reveal important differences between the Chicken and mammals The human IL-1 family contains 11 genes encoded at three separate loci. Nine, including IL-1R antagonist (IL-1RN), are present at a single locus on chromosome 2, whereas IL-18 and IL-33 lie on chromosomes 11 and 9, respectively. There are currently only two known orthologs in the chicken, IL-1β and IL-18, which are encoded on chromosomes 22 and 24, respectively. Two novel chicken IL-1 family sequences were identified from expressed sequence tag libraries, representing secretory and intracellular (icIL-1RN) structural variants of the IL-1RN gene, as seen in mammals. Two further putative splice variants (SVs) of both chicken IL-1RN (chIL-1RN) structural variants were also isolated. Alternative splicing of human icIL-1RN gives three different transcripts; there are no known SVs for human secretory IL-1RN. The chicken icIL-1RN SVs differ from those found in human icIL-1RN in terms of the rearrangements involved. In mammals, IL-1RN inhibits IL-1 activity by physically occupying the IL-1 type I receptor. Both full-length structural variants of chIL-1RN exhibited biological activity similar to their mammalian orthologs in a macrophage cell line bioassay. The four SVs, however, were not biologically active. The chicken IL-1 family is more fragmented in the genome than those of mammals, particularly in that the large multigene locus seen in mammals is absent. This suggests differential evolution of the family since the divergence of birds and mammals from a common ancestor, and makes determination of the full repertoire of chicken IL-1 family members more challenging.

year: 2012

title: Assessment of impacts of mechanical spat harvesting on the surf clams of Te Oneroa a Tōhē

authors: Ross, Philip M.

abstract: Much of the mussel spat used to seed mussel aquaculture farms throughout New Zealand is sourced from Te Oneroa a Tōhē (90 Mile Beach) in Te Hiku (far north of New Zealand). The mussel spat washes ashore attached to seaweed and hydroids where it is collected by spat harvesters and transported to mussel farms around the country to be on-grown. The collection of Te Hiku spat and seaweed was originally done by hand. However, the methods used have evolved over time and mussel spat is now primarily collected using mechanical loaders operating in the surf zone. Local iwi, hapu and the wider community have recently voiced their concerns about the impacts of this harvesting method. Specifically, there are concerns about the impact of loaders operating on top of toheroa (Paphies ventricosa) and tuatua (Paphies subtriangulata) beds or other shellfish inhabiting in the intertidal and subtidal areas of Te Oneroa a Tōhē. Consequently, research into the ecological impacts of mechanical spat harvesting was conducted to address the concerns of the community and inform the management of the Te Hiku spat fishery. 
This research aimed to examine the ecological impacts of a ‘worst case scenario’ by (1) simulating an intensity of spat harvesting activity much greater than would be anticipated in the ‘real world’ and (2) conducting the research at high density tuatua beds where impacts would potentially be greatest. Adult toheroa were not targeted in the experiment to avoid unnecessary impacts on already depleted toheroa populations. At each of three sites on Te Oneroa a Tōhē, nine spat harvesting loaders were repeatedly driven in and out of the surf, over shellfish beds, for 75 minutes leading up to the low tide. Once loader activity ceased, a sampling team made up of mana whenua, local primary school children, spat harvesters and staff from MPI, Te Ohu Kaimoana and the University of Waikato collected clams from the intertidal area. Collections were made from both impact and control (non-impact) sites, where (a) the number of crushed shells was quantified and (b) the self-righting and burying abilities of tuatua from impact and control areas were compared to provide an estimate of sub-lethal effects. 
There was no detectable impact of mechanical spat harvesting loaders on tuatua (or the juvenile toheroa that were present in the sampled tuatua beds) when these surf clams were either fully or partially buried in sands of Te Oneroa a Tōhē. Rates of shell damage were less 2 than 6.1% and were similar in impact and control areas indicating much of the observed shell damage was caused by the sediment corers that were used to extract samples from the beach. Similarly, being driven over by loaders did not affect the ability or speed at which tuatua were able to right and bury themselves in the sediment. When standing on end these clams appear robust to the forces exerted by loaders upon the sediment surface. However, beach cast clams (both tuatua and toheroa), lying on top of the sediment on their sides are vulnerable to crushing by vehicles. This includes juvenile clams that ‘float’ to the beach surface where multiple loader passes liquefy the surface sediment. Mortality in these beach cast clams was not well captured by the sampling methodology used in this study, but was observed at two of the three sites sampled. It was not possible to quantify this type of mortality during this study. However, the number of clams crushed on the beach surface was small relative to the high abundances of clams within the sediment and the impact is not considered ecologically significant at the scale the individual shellfish beds or the entire beach. 
Overall, there was nothing observed during the course of this experiment to suggest that mechanical harvesting is having a significant ecological effect on the toheroa or tuatua of Te Oneroa a Tōhē. Mechanical spat harvesting did result in some clam mortality during the course of this experiment, and it is likely that some mortality will occur in the future when clams are present on the beach surface. However, the level of mortality observed, and anticipated, is unlikely to compromise the viability of either clam species. 
To minimise clam mortality caused by spat harvesting, loader operators should endeavour to avoid areas where large numbers of surf clams are either beach cast or are observed washing around in the shallow subtidal. It would also be prudent, because of the depressed state of toheroa populations on Te Oneroa a Tōhē, for spat harvesters to have up-to-date information about the location of toheroa beds and avoid them where possible. 
It should be noted that concerns have been raised as to whether the driving of loaders during this study was equivalent to real world operations. However, the collection of operational data during this experiment, the proposed installation of GPS trackers on all loaders and the use of observers will allow for monitoring and enforcement of operating procedures established in the industry code of practise.

text: Assessment of impacts of mechanical spat harvesting on the surf clams of Te Oneroa a Tōhē Much of the mussel spat used to seed mussel aquaculture farms throughout New Zealand is sourced from Te Oneroa a Tōhē (90 Mile Beach) in Te Hiku (far north of New Zealand). The mussel spat washes ashore attached to seaweed and hydroids where it is collected by spat harvesters and transported to mussel farms around the country to be on-grown. The collection of Te Hiku spat and seaweed was originally done by hand. However, the methods used have evolved over time and mussel spat is now primarily collected using mechanical loaders operating in the surf zone. Local iwi, hapu and the wider community have recently voiced their concerns about the impacts of this harvesting method. Specifically, there are concerns about the impact of loaders operating on top of toheroa (Paphies ventricosa) and tuatua (Paphies subtriangulata) beds or other shellfish inhabiting in the intertidal and subtidal areas of Te Oneroa a Tōhē. Consequently, research into the ecological impacts of mechanical spat harvesting was conducted to address the concerns of the community and inform the management of the Te Hiku spat fishery. 
This research aimed to examine the ecological impacts of a ‘worst case scenario’ by (1) simulating an intensity of spat harvesting activity much greater than would be anticipated in the ‘real world’ and (2) conducting the research at high density tuatua beds where impacts would potentially be greatest. Adult toheroa were not targeted in the experiment to avoid unnecessary impacts on already depleted toheroa populations. At each of three sites on Te Oneroa a Tōhē, nine spat harvesting loaders were repeatedly driven in and out of the surf, over shellfish beds, for 75 minutes leading up to the low tide. Once loader activity ceased, a sampling team made up of mana whenua, local primary school children, spat harvesters and staff from MPI, Te Ohu Kaimoana and the University of Waikato collected clams from the intertidal area. Collections were made from both impact and control (non-impact) sites, where (a) the number of crushed shells was quantified and (b) the self-righting and burying abilities of tuatua from impact and control areas were compared to provide an estimate of sub-lethal effects. 
There was no detectable impact of mechanical spat harvesting loaders on tuatua (or the juvenile toheroa that were present in the sampled tuatua beds) when these surf clams were either fully or partially buried in sands of Te Oneroa a Tōhē. Rates of shell damage were less 2 than 6.1% and were similar in impact and control areas indicating much of the observed shell damage was caused by the sediment corers that were used to extract samples from the beach. Similarly, being driven over by loaders did not affect the ability or speed at which tuatua were able to right and bury themselves in the sediment. When standing on end these clams appear robust to the forces exerted by loaders upon the sediment surface. However, beach cast clams (both tuatua and toheroa), lying on top of the sediment on their sides are vulnerable to crushing by vehicles. This includes juvenile clams that ‘float’ to the beach surface where multiple loader passes liquefy the surface sediment. Mortality in these beach cast clams was not well captured by the sampling methodology used in this study, but was observed at two of the three sites sampled. It was not possible to quantify this type of mortality during this study. However, the number of clams crushed on the beach surface was small relative to the high abundances of clams within the sediment and the impact is not considered ecologically significant at the scale the individual shellfish beds or the entire beach. 
Overall, there was nothing observed during the course of this experiment to suggest that mechanical harvesting is having a significant ecological effect on the toheroa or tuatua of Te Oneroa a Tōhē. Mechanical spat harvesting did result in some clam mortality during the course of this experiment, and it is likely that some mortality will occur in the future when clams are present on the beach surface. However, the level of mortality observed, and anticipated, is unlikely to compromise the viability of either clam species. 
To minimise clam mortality caused by spat harvesting, loader operators should endeavour to avoid areas where large numbers of surf clams are either beach cast or are observed washing around in the shallow subtidal. It would also be prudent, because of the depressed state of toheroa populations on Te Oneroa a Tōhē, for spat harvesters to have up-to-date information about the location of toheroa beds and avoid them where possible. 
It should be noted that concerns have been raised as to whether the driving of loaders during this study was equivalent to real world operations. However, the collection of operational data during this experiment, the proposed installation of GPS trackers on all loaders and the use of observers will allow for monitoring and enforcement of operating procedures established in the industry code of practise.

year: 2020