title: Networks of inflammation, depression, and cognition in aging males and females.

authors: Chalmers, Rebecca A.

subjects: Aging

abstract: BACKGROUND: Prioritizing the maintenance of healthy cognitive aging and personalizing preventive interventions to enhance their effectiveness is crucial as the global population ages. Systemic inflammation and depression in older people have been associated with decreased levels of cognition but results have been inconsistent. AIMS: To explore the interactive network of inflammation, depression and cognition by sex in older people. 
METHODS: We used novel network analysis to explore the unique associations between inflammatory biomarkers, depression, cognition, and somatic, genetic, and lifestyle risk factors in an older (aged 70-90 years), non-demented, community-dwelling sample from the longitudinal Sydney Memory and Aging Study (N = 916) at baseline and at a two-year follow-up. 
RESULTS: The networks of biomarkers, depression, cognition, and relevant covariates were significantly different between males and females. A stable negative link between depression and cognition was found in females only; a stable positive association between biomarker interleukin-6 and depression was found in females only; and a stable positive association between biomarker interleukin-8 and alcohol was found in females only. For both males and females, a stable, positive relationship was found between the presence of APOE-ε4 gene and biomarker C-reactive protein; between education and cognition; and between biomarker interleukin-6 and all other biomarkers. 
CONCLUSIONS: These findings suggest different psychophysiological mechanisms underlie the interactive network of biomarkers, depression and cognition in males and females that should be considered when designing personalized preventive interventions to maintain cognitively healthy aging.

text: Networks of inflammation, depression, and cognition in aging males and females. BACKGROUND: Prioritizing the maintenance of healthy cognitive aging and personalizing preventive interventions to enhance their effectiveness is crucial as the global population ages. Systemic inflammation and depression in older people have been associated with decreased levels of cognition but results have been inconsistent. AIMS: To explore the interactive network of inflammation, depression and cognition by sex in older people. 
METHODS: We used novel network analysis to explore the unique associations between inflammatory biomarkers, depression, cognition, and somatic, genetic, and lifestyle risk factors in an older (aged 70-90 years), non-demented, community-dwelling sample from the longitudinal Sydney Memory and Aging Study (N = 916) at baseline and at a two-year follow-up. 
RESULTS: The networks of biomarkers, depression, cognition, and relevant covariates were significantly different between males and females. A stable negative link between depression and cognition was found in females only; a stable positive association between biomarker interleukin-6 and depression was found in females only; and a stable positive association between biomarker interleukin-8 and alcohol was found in females only. For both males and females, a stable, positive relationship was found between the presence of APOE-ε4 gene and biomarker C-reactive protein; between education and cognition; and between biomarker interleukin-6 and all other biomarkers. 
CONCLUSIONS: These findings suggest different psychophysiological mechanisms underlie the interactive network of biomarkers, depression and cognition in males and females that should be considered when designing personalized preventive interventions to maintain cognitively healthy aging.

year: 2022-10

title: Does haste make waste? The human factors of overtaking land design

authors: Charlton, Samuel G.

subjects: lane design

abstract: The aim of this research was to improve overtaking safety and efficiency through improvements in road signage, markings, geometry and speed control associated with the placement and layout of passing lanes. The approach of the research was to explore the effects of several types of overtaking lane treatments in the safety and controlled environment of a state-of-the-art driving simulator. It was found that under the most benign conditions there were no differential effects of the three treatments. With poorer visibility or more taxing road geometry, the drivers relied more heavily on the road markings and signage and the effects of the treatments become more pronounced. The sensitivity to the more "challenging" situations was borne out by the greater speed differential between merge area sections at these sites.

text: Does haste make waste? The human factors of overtaking land design The aim of this research was to improve overtaking safety and efficiency through improvements in road signage, markings, geometry and speed control associated with the placement and layout of passing lanes. The approach of the research was to explore the effects of several types of overtaking lane treatments in the safety and controlled environment of a state-of-the-art driving simulator. It was found that under the most benign conditions there were no differential effects of the three treatments. With poorer visibility or more taxing road geometry, the drivers relied more heavily on the road markings and signage and the effects of the treatments become more pronounced. The sensitivity to the more "challenging" situations was borne out by the greater speed differential between merge area sections at these sites.

year: 2001

title: Whānau mentoring, Māori youth and crime

authors: Joseph, Robert

abstract: This article will discuss how the whänau was the traditional institution for teaching and nurturing children through (among other things) effective mentoring, and how children were taught tikanga, or the ‘right way’ to think, speak, act and become. Traditional leadership development, whänau dysfunction and whänau renewal are also discussed, followed by my conclusions. This article will not be discussing the place of colonisation, high unemployment, lower education rates and other socio-economic disparities among Mäori that play a part in the causes and perpetuation of Mäori youth and crime. A discussion on the Treaty of Waitangi, indigenous rights, and Mäori development is also omitted although the importance of each of these areas is acknowledged. As the theme of this issue of Childrenz Issues is ‘seeking pathways beyond colonisation’, the focus of this article is on Mäori dealing appropriately with the problems of Mäori youth and crime through effective mentoring within the institution of the whänau.

text: Whānau mentoring, Māori youth and crime This article will discuss how the whänau was the traditional institution for teaching and nurturing children through (among other things) effective mentoring, and how children were taught tikanga, or the ‘right way’ to think, speak, act and become. Traditional leadership development, whänau dysfunction and whänau renewal are also discussed, followed by my conclusions. This article will not be discussing the place of colonisation, high unemployment, lower education rates and other socio-economic disparities among Mäori that play a part in the causes and perpetuation of Mäori youth and crime. A discussion on the Treaty of Waitangi, indigenous rights, and Mäori development is also omitted although the importance of each of these areas is acknowledged. As the theme of this issue of Childrenz Issues is ‘seeking pathways beyond colonisation’, the focus of this article is on Mäori dealing appropriately with the problems of Mäori youth and crime through effective mentoring within the institution of the whänau.

year: 2007-01