title: Catecholamine physiology in the sheep

authors: Pearson, Allan John

abstract: A study of catecholamine physiology in the sheep has been carried out with emphasis on the measurement of plasma catecholamine levels and their interactions with lactic acid and cortisol. The plasma dynamics of the catecholamines were first examined under laboratory conditions followed by an assessment of sympathetic responses to a variety of environmental stimuli.
Catecholamine levels were monitored in the plasma of sheep during and after 90 minute infusions of 1-dopa, dopamine, noradrenaline and adrenaline. A 2-compartmental pharmacokinetic model of 1-dopa plasma dynamics was constructed and the half-lives of the fast and slow decay curves determined. Estimation of the half-lives of dopamine, noradrenaline and adrenaline was prevented by a period of increased endogenous secretion that occurred on the termination of the infusions. A hypothesis based on the hypotension developed by sheep on the arrest of catecholamine infusions of this nature was developed to explain the adrenergic activity observed. Lactic acid levels rose markedly during the adrenaline infusions with a much smaller response during noradrenaline infusions while a biphasic cortisol response to both the noradrenaline and adrenaline infusions was observed.
A set of blood samples was collected from each of 6 cannulated lambs at various stages of a journey from the farm to the abattoir. Catecholamine levels remained consistently elevated throughout the experiment before rising to a very high peak upon electrical stunning prior to slaughter. Plasma lactic acid peaks were associated with mustering and washing while cortisol remained high throughout the experiment until penning at the abattoir when it fell sharply to baseline levels. Subsequently it rose overnight. The physiological basis of these observations is discussed in relation to the transport of stock and the use of these blood substances in assessing the reactions of domestic animals to their environment.
The massive catecholamine release in response to electrical stunning was further studied in a series of experiments. Significant differences between lamb mobs slaughtered at an abattoir appeared but a relationship was not found between the catecholamine plasma concentrations and the haemorrhagic lesion known as “blood splash” caused by electrical stunning. Short-term stressors encountered by the lambs at the abattoir had no effect on the blood splash incidence but some evidence suggested a link with the previous behavioural and handling conditions of slaughtered lambs. Both the α-adrenergic and the β-adrenergic blocking drugs phentolamine and propranolol were effective in suppressing blood splash and the physiological basis of this observation is considered.
Some preliminary experiments to investigate catecholamine involvement in the neurological disease of ryegrass staggers in sheep are described together with a description of the intense ingestive behaviour and the possible taming effects induced by the central dopaminergic receptor blocker haloperidol.
The application of these and other results to future agricultural research programmes is considered in the light of recent developments in the understanding of the multiple roles of these substances in mammalian physiology.

text: Catecholamine physiology in the sheep A study of catecholamine physiology in the sheep has been carried out with emphasis on the measurement of plasma catecholamine levels and their interactions with lactic acid and cortisol. The plasma dynamics of the catecholamines were first examined under laboratory conditions followed by an assessment of sympathetic responses to a variety of environmental stimuli.
Catecholamine levels were monitored in the plasma of sheep during and after 90 minute infusions of 1-dopa, dopamine, noradrenaline and adrenaline. A 2-compartmental pharmacokinetic model of 1-dopa plasma dynamics was constructed and the half-lives of the fast and slow decay curves determined. Estimation of the half-lives of dopamine, noradrenaline and adrenaline was prevented by a period of increased endogenous secretion that occurred on the termination of the infusions. A hypothesis based on the hypotension developed by sheep on the arrest of catecholamine infusions of this nature was developed to explain the adrenergic activity observed. Lactic acid levels rose markedly during the adrenaline infusions with a much smaller response during noradrenaline infusions while a biphasic cortisol response to both the noradrenaline and adrenaline infusions was observed.
A set of blood samples was collected from each of 6 cannulated lambs at various stages of a journey from the farm to the abattoir. Catecholamine levels remained consistently elevated throughout the experiment before rising to a very high peak upon electrical stunning prior to slaughter. Plasma lactic acid peaks were associated with mustering and washing while cortisol remained high throughout the experiment until penning at the abattoir when it fell sharply to baseline levels. Subsequently it rose overnight. The physiological basis of these observations is discussed in relation to the transport of stock and the use of these blood substances in assessing the reactions of domestic animals to their environment.
The massive catecholamine release in response to electrical stunning was further studied in a series of experiments. Significant differences between lamb mobs slaughtered at an abattoir appeared but a relationship was not found between the catecholamine plasma concentrations and the haemorrhagic lesion known as “blood splash” caused by electrical stunning. Short-term stressors encountered by the lambs at the abattoir had no effect on the blood splash incidence but some evidence suggested a link with the previous behavioural and handling conditions of slaughtered lambs. Both the α-adrenergic and the β-adrenergic blocking drugs phentolamine and propranolol were effective in suppressing blood splash and the physiological basis of this observation is considered.
Some preliminary experiments to investigate catecholamine involvement in the neurological disease of ryegrass staggers in sheep are described together with a description of the intense ingestive behaviour and the possible taming effects induced by the central dopaminergic receptor blocker haloperidol.
The application of these and other results to future agricultural research programmes is considered in the light of recent developments in the understanding of the multiple roles of these substances in mammalian physiology.

year: 1979

title: Mapping the Geographical and Literary Boundaries of Los Angeles: A Real and Imagined City

authors: Granville, Scott

subjects: Los Angeles

abstract: In Los Angeles, the influence of Hollywood and the film industry, combined with a non-stop barrage of media images, has blurred the line between the real and imaged.  The literature reveals a city exploding with cultural, racial and social differences, making Los Angeles a confusing and alienating place. The literature of Los Angeles reflects the changing face of the city. Los Angeles was always a city with a promising future, economic booms and optimism seemed to suggest that here was a place where the American Dream really could come true. Thousands travelled west in search of sunshine, oranges and a life that formerly, they could only dream of having. Yet, the literature of Los Angeles has highlighted the city's actual history together with a realization of undercurrents of violence, prejudice, depression and shattered dreams.  The past, present and future is used to reveal a city that is in stark opposition to the Los Angeles, waves of immigrants came to find.  
This thesis explores the idea of the dreamer coming west to Los Angeles within the literature and the variety of ways in the travellers' romantic notions of Los Angeles as a city of promise, is betrayed, leaving a desperate people in its wake.  The literature shows that beneath the shiny surface of a city founded on sunshine and prosperity, corruption reached all levels of society and the 'mean streets' abound.
	Later, influenced by an overwhelming feeling of powerlessness caused by Post-war nuclear depression, McCarthyism, loss of identity, and living in a city fragmented by racial tension and an ever growing gap between the very rich and the very poor, the literature of Los Angeles reflects not only the fears of that city, but of American society as a whole.  The collision of technology, rapid progression and population explosion turned Los Angeles into a disconnected city, where the real and imagined merge in a cityscape that demonstrates a conflicting combination of historical replication, original design and movie-set inspiration.  Nothing is ever what it appears to be in Los Angeles.

text: Mapping the Geographical and Literary Boundaries of Los Angeles: A Real and Imagined City In Los Angeles, the influence of Hollywood and the film industry, combined with a non-stop barrage of media images, has blurred the line between the real and imaged.  The literature reveals a city exploding with cultural, racial and social differences, making Los Angeles a confusing and alienating place. The literature of Los Angeles reflects the changing face of the city. Los Angeles was always a city with a promising future, economic booms and optimism seemed to suggest that here was a place where the American Dream really could come true. Thousands travelled west in search of sunshine, oranges and a life that formerly, they could only dream of having. Yet, the literature of Los Angeles has highlighted the city's actual history together with a realization of undercurrents of violence, prejudice, depression and shattered dreams.  The past, present and future is used to reveal a city that is in stark opposition to the Los Angeles, waves of immigrants came to find.  
This thesis explores the idea of the dreamer coming west to Los Angeles within the literature and the variety of ways in the travellers' romantic notions of Los Angeles as a city of promise, is betrayed, leaving a desperate people in its wake.  The literature shows that beneath the shiny surface of a city founded on sunshine and prosperity, corruption reached all levels of society and the 'mean streets' abound.
	Later, influenced by an overwhelming feeling of powerlessness caused by Post-war nuclear depression, McCarthyism, loss of identity, and living in a city fragmented by racial tension and an ever growing gap between the very rich and the very poor, the literature of Los Angeles reflects not only the fears of that city, but of American society as a whole.  The collision of technology, rapid progression and population explosion turned Los Angeles into a disconnected city, where the real and imagined merge in a cityscape that demonstrates a conflicting combination of historical replication, original design and movie-set inspiration.  Nothing is ever what it appears to be in Los Angeles.

year: 2007

title: Photography within te ao Māori: Decolonising the photographic lens

authors: Hill, Rodrigo

abstract: Ūkaipō: Wānanga, places of origin and photographic representation. 
Ūkaipō recognises the cultural, emotional, and spiritual along with the physical ties a Māori has with their place of origin, even if it is not their place of birth, emphasising grounded forms of connection between people and place and subsequent understandings of places and spaces.  Hence the importance today of people asserting their pēpeha, tohu whenua landmarks with which they most strongly identify, consolidating their ‘birth of place’ or ‘place of birth’.

text: Photography within te ao Māori: Decolonising the photographic lens Ūkaipō: Wānanga, places of origin and photographic representation. 
Ūkaipō recognises the cultural, emotional, and spiritual along with the physical ties a Māori has with their place of origin, even if it is not their place of birth, emphasising grounded forms of connection between people and place and subsequent understandings of places and spaces.  Hence the importance today of people asserting their pēpeha, tohu whenua landmarks with which they most strongly identify, consolidating their ‘birth of place’ or ‘place of birth’.

year: 2024