title: Algorithm selection on data streams

authors: van Rijn, Jan N.

subjects: Data Stream Mining

abstract: We explore the possibilities of meta-learning on data streams, in particular algorithm selection. In a first experiment we calculate the characteristics of a small sample of a data stream, and try to predict which classifier performs best on the entire stream. This yields promising results and interesting patterns. In a second experiment, we build a meta-classifier that predicts, based on measurable data characteristics in a window of the data stream, the best classifier for the next window. The results show that this meta-algorithm is very competitive with state of the art ensembles, such as OzaBag, OzaBoost and Leveraged Bagging. The results of all experiments are made publicly available in an online experiment database, for the purpose of verifiability, reproducibility and generalizability.

text: Algorithm selection on data streams We explore the possibilities of meta-learning on data streams, in particular algorithm selection. In a first experiment we calculate the characteristics of a small sample of a data stream, and try to predict which classifier performs best on the entire stream. This yields promising results and interesting patterns. In a second experiment, we build a meta-classifier that predicts, based on measurable data characteristics in a window of the data stream, the best classifier for the next window. The results show that this meta-algorithm is very competitive with state of the art ensembles, such as OzaBag, OzaBoost and Leveraged Bagging. The results of all experiments are made publicly available in an online experiment database, for the purpose of verifiability, reproducibility and generalizability.

year: 2014

title: Mechanisms of host manipulation by Neisseria gonorrhoeae

authors: Walker, Emma Jane

subjects: gonorrhoea (Neisseria gonorrhoeae)

abstract: Neisseria gonorrhoeae (also known as gonococcus) has been causing gonorrhoea in humans since ancient Egyptian times. Today, global gonorrhoea infections are rising at an alarming rate, in concert with an increasing number of antimicrobial-resistant strains. The gonococcus has concurrently evolved several intricate mechanisms that promote pathogenesis by evading both host immunity and defeating common therapeutic interventions. Central to these adaptations is the ability of the gonococcus to manipulate various host microenvironments upon infection. For example, the gonococcus can survive within neutrophils through direct regulation of both the oxidative burst response and maturation of the phagosome; a concerning trait given the important role neutrophils have in defending against invading pathogens. Hence, a detailed understanding of how N. gonorrhoeae exploits the human host to establish and maintain infection is crucial for combating this pathogen. This review summarizes the mechanisms behind host manipulation, with a central focus on the exploitation of host epithelial cell signaling to promote colonization and invasion of the epithelial lining, the modulation of the host immune response to evade both innate and adaptive defenses, and the manipulation of host cell death pathways to both assist colonization and combat antimicrobial activities of innate immune cells. Collectively, these pathways act in concert to enable N. gonorrhoeae to colonize and invade a wide array of host tissues, both establishing and disseminating gonococcal infection.

text: Mechanisms of host manipulation by Neisseria gonorrhoeae Neisseria gonorrhoeae (also known as gonococcus) has been causing gonorrhoea in humans since ancient Egyptian times. Today, global gonorrhoea infections are rising at an alarming rate, in concert with an increasing number of antimicrobial-resistant strains. The gonococcus has concurrently evolved several intricate mechanisms that promote pathogenesis by evading both host immunity and defeating common therapeutic interventions. Central to these adaptations is the ability of the gonococcus to manipulate various host microenvironments upon infection. For example, the gonococcus can survive within neutrophils through direct regulation of both the oxidative burst response and maturation of the phagosome; a concerning trait given the important role neutrophils have in defending against invading pathogens. Hence, a detailed understanding of how N. gonorrhoeae exploits the human host to establish and maintain infection is crucial for combating this pathogen. This review summarizes the mechanisms behind host manipulation, with a central focus on the exploitation of host epithelial cell signaling to promote colonization and invasion of the epithelial lining, the modulation of the host immune response to evade both innate and adaptive defenses, and the manipulation of host cell death pathways to both assist colonization and combat antimicrobial activities of innate immune cells. Collectively, these pathways act in concert to enable N. gonorrhoeae to colonize and invade a wide array of host tissues, both establishing and disseminating gonococcal infection.

year: 2023-02-03

title: Akuhata Koropango Lipsey

authors: Hart, Philip

abstract: The eldest son of George and Ema Lipsey, Augie, as he was known, was most notable, and popular, as a sportsman. A good rugby player in his youth, he later became a keen golfer. As well, he owned and raced horses, an interest that would result in his financial downfall. Although a farmer off and on, he had no farming skills and had to take on other work, in his last years working in a billiard saloon.  
After marrying an English girl and fathering several children, he proved to be a poor provider for his family. His wife, well liked for her involvement in various worthy causes, especially those organized by the Anglican Church, had to teach dancing and to milk cows to raise money, for Lipsey squandered his inheritance, notably on the Auckland racecourse. His method of meeting his debts and living expenses was to sell land, and although over many years officials tried to prevent this (to protect his family), they gradually let him have his way. Bankrupted twice, on his death his family was left in poverty.

text: Akuhata Koropango Lipsey The eldest son of George and Ema Lipsey, Augie, as he was known, was most notable, and popular, as a sportsman. A good rugby player in his youth, he later became a keen golfer. As well, he owned and raced horses, an interest that would result in his financial downfall. Although a farmer off and on, he had no farming skills and had to take on other work, in his last years working in a billiard saloon.  
After marrying an English girl and fathering several children, he proved to be a poor provider for his family. His wife, well liked for her involvement in various worthy causes, especially those organized by the Anglican Church, had to teach dancing and to milk cows to raise money, for Lipsey squandered his inheritance, notably on the Auckland racecourse. His method of meeting his debts and living expenses was to sell land, and although over many years officials tried to prevent this (to protect his family), they gradually let him have his way. Bankrupted twice, on his death his family was left in poverty.

year: 2016