title: Does Hsp60 provide a link between mitochondrial stress and inflammation in Diabetes Mellitus?

authors: Juwono, Joshua

abstract: The focus of this review is to summarise the known relationships between the expression of Heat Shock Protein 60 (Hsp60) and its association with the pathogenesis of Type 1 and Type 2 Diabetes Mellitus. Hsp60 is a mitochondrial stress protein that is induced by mitochondrial impairment. It is known to be secreted from a number of cell types and circulating levels have been documented in both Type 1 and 2 Diabetes mellitus patients. The biological significance of extracellular Hsp60 however, remains to be established. We will examine the links between Hsp60 and cellular anti and pro- inflammatory processes and specifically address how Hsp60 appears to affect immune inflammation by at least two different mechanisms: as a ligand for innate immune receptors and as an antigen recognized by adaptive immune receptors. We will also look at the role of Hsp60 during immune cell activation in atherosclerosis, a significant risk factor during the pathogenesis of Diabetes Mellitus.

text: Does Hsp60 provide a link between mitochondrial stress and inflammation in Diabetes Mellitus? The focus of this review is to summarise the known relationships between the expression of Heat Shock Protein 60 (Hsp60) and its association with the pathogenesis of Type 1 and Type 2 Diabetes Mellitus. Hsp60 is a mitochondrial stress protein that is induced by mitochondrial impairment. It is known to be secreted from a number of cell types and circulating levels have been documented in both Type 1 and 2 Diabetes mellitus patients. The biological significance of extracellular Hsp60 however, remains to be established. We will examine the links between Hsp60 and cellular anti and pro- inflammatory processes and specifically address how Hsp60 appears to affect immune inflammation by at least two different mechanisms: as a ligand for innate immune receptors and as an antigen recognized by adaptive immune receptors. We will also look at the role of Hsp60 during immune cell activation in atherosclerosis, a significant risk factor during the pathogenesis of Diabetes Mellitus.

year: 2016

title: Cross-case analysis

authors: Ryan, Chris

abstract: Prior to the development of low-cost computing and the ease of completing statistical analysis, case studies played a significant role in the development of the social sciences. However, since the mid-1990s statistical modelling and empirically driven work has come to dominate academic literature; yet there remain epistemological similarities between some forms of case study work and statistical modelling. Nonetheless, issues of the qualitative versus quantitative divide and the purported role of value judgments made by the researchers have in part muddied the waters until quite recently, when the researchers using statistical methods started to adopt the use of the first person in their writing and began to recognise that the choice of a given statistical technique is just as surely a value judgment or exercise of experience and expertise as is any interpretation of text by a qualitative researcher. Similarly, qualitative researchers have become increasingly familiar with textual analysis using software programmes based on neural network theory, and a new generation of researchers have become comfortable with a mixed method mode of analysis.

text: Cross-case analysis Prior to the development of low-cost computing and the ease of completing statistical analysis, case studies played a significant role in the development of the social sciences. However, since the mid-1990s statistical modelling and empirically driven work has come to dominate academic literature; yet there remain epistemological similarities between some forms of case study work and statistical modelling. Nonetheless, issues of the qualitative versus quantitative divide and the purported role of value judgments made by the researchers have in part muddied the waters until quite recently, when the researchers using statistical methods started to adopt the use of the first person in their writing and began to recognise that the choice of a given statistical technique is just as surely a value judgment or exercise of experience and expertise as is any interpretation of text by a qualitative researcher. Similarly, qualitative researchers have become increasingly familiar with textual analysis using software programmes based on neural network theory, and a new generation of researchers have become comfortable with a mixed method mode of analysis.

year: 2012

title: Pōwhiri process in mental health research

authors: McClintock, Kahu

subjects: indigenous mental health research

abstract: Within the health research context, indigenous people globally have a commitment to provide their own solutions. Māori, the indigenous people of Aotearoa (New Zealand) value the traditional Pōwhiri process of engagement and participation in mental health research. The practices and protocols within the Pōwhiri process (use in the Doctorate of Philosophy (2010) and Auckland University) are premised on the notion of respect and positive relationships between the tangata whenua (hosts or research participants) and manuwhiri (guests or researchers). This paper briefly describes the Pōwhiri process, which may be a model applicable to research with other indigenous cultures.

text: Pōwhiri process in mental health research Within the health research context, indigenous people globally have a commitment to provide their own solutions. Māori, the indigenous people of Aotearoa (New Zealand) value the traditional Pōwhiri process of engagement and participation in mental health research. The practices and protocols within the Pōwhiri process (use in the Doctorate of Philosophy (2010) and Auckland University) are premised on the notion of respect and positive relationships between the tangata whenua (hosts or research participants) and manuwhiri (guests or researchers). This paper briefly describes the Pōwhiri process, which may be a model applicable to research with other indigenous cultures.

year: 2010