title: Enzyme evolution: innovation is easy, optimization is complicated

authors: Newton, Matilda S.

abstract: Enzymes have been evolving to catalyze new chemical reactions for billions of years, and will continue to do so for billions more. Here, we review examples in which evolutionary biochemists have used big data and high-throughput experimental tools to shed new light on the enormous functional diversity of extant enzymes, and the evolutionary processes that gave rise to it. We discuss the role that gene loss has played in enzyme evolution, as well as the more familiar processes of gene duplication and divergence. We also review insightful studies that relate not only catalytic activity, but also a host of other biophysical and cellular parameters, to organismal fitness. Finally, we provide an updated perspective on protein engineering, based on our new-found appreciation that most enzymes are sloppy and mediocre.

text: Enzyme evolution: innovation is easy, optimization is complicated Enzymes have been evolving to catalyze new chemical reactions for billions of years, and will continue to do so for billions more. Here, we review examples in which evolutionary biochemists have used big data and high-throughput experimental tools to shed new light on the enormous functional diversity of extant enzymes, and the evolutionary processes that gave rise to it. We discuss the role that gene loss has played in enzyme evolution, as well as the more familiar processes of gene duplication and divergence. We also review insightful studies that relate not only catalytic activity, but also a host of other biophysical and cellular parameters, to organismal fitness. Finally, we provide an updated perspective on protein engineering, based on our new-found appreciation that most enzymes are sloppy and mediocre.

year: 2018

title: Low-cost autonomous 3-D monitoring systems for hydraulic engineering environments and applications with limited accuracy requirements

authors: Kularatna, Nihal

subjects: Autonomous 3-D monitoring

abstract: The details of developing autonomous 3-D motion monitoring systems based on commercial off-the-shelf (COTS) motion sensors for hydraulic environments are discussed. Possible areas of application, are river bed sediment transport monitoring and monitoring the agitation and other physical parameters inside milk vats with a mechanized agitator. Simplified calculations of inertial navigation systems (INSs) such as Euler angle method, MATLAB programs for further processing, power management systems for autonomous operation including the possibility of inductive power transfer (IPT) and use of microelectromechanical systems (MEMS) technology are discussed. Experimental results for proof of concept systems are highlighted.

text: Low-cost autonomous 3-D monitoring systems for hydraulic engineering environments and applications with limited accuracy requirements The details of developing autonomous 3-D motion monitoring systems based on commercial off-the-shelf (COTS) motion sensors for hydraulic environments are discussed. Possible areas of application, are river bed sediment transport monitoring and monitoring the agitation and other physical parameters inside milk vats with a mechanized agitator. Simplified calculations of inertial navigation systems (INSs) such as Euler angle method, MATLAB programs for further processing, power management systems for autonomous operation including the possibility of inductive power transfer (IPT) and use of microelectromechanical systems (MEMS) technology are discussed. Experimental results for proof of concept systems are highlighted.

year: 2010

title: Māori data sovereignty and privacy

authors: Kukutai, Tahu

abstract: Privacy is a fundamental human right. One of its most important aspects is information privacy – providing individuals with control over the way in which their personal data is collected, used, disclosed and otherwise handled. Existing information privacy regulation neither recognises nor protects the collective privacy rights of Indigenous peoples. This paper explores Indigenous data
privacy, and the challenges and opportunities, in the context of Aotearoa. It has two aims: to identify gaps in existing data privacy approaches with regards to Indigenous data, and to provide a foundation for progressing alternative privacy paradigms. We argue that while personal data protection is necessary, it is insufficient to meet the needs of Māori and Aotearoa more broadly. In so doing, we draw on three areas of research: Indigenous and Māori data sovereignty; data and information privacy,
including collective privacy; and Māori and Indigenous privacy perspectives. We examine key features of the Aotearoa privacy context – including the Privacy Act 2020 (NZ) – and consider the implications of te Tiriti o Waitangi and tikanga Māori for alternative privacy approaches. Future options, including legal and extra-legal measures, are proposed.

text: Māori data sovereignty and privacy Privacy is a fundamental human right. One of its most important aspects is information privacy – providing individuals with control over the way in which their personal data is collected, used, disclosed and otherwise handled. Existing information privacy regulation neither recognises nor protects the collective privacy rights of Indigenous peoples. This paper explores Indigenous data
privacy, and the challenges and opportunities, in the context of Aotearoa. It has two aims: to identify gaps in existing data privacy approaches with regards to Indigenous data, and to provide a foundation for progressing alternative privacy paradigms. We argue that while personal data protection is necessary, it is insufficient to meet the needs of Māori and Aotearoa more broadly. In so doing, we draw on three areas of research: Indigenous and Māori data sovereignty; data and information privacy,
including collective privacy; and Māori and Indigenous privacy perspectives. We examine key features of the Aotearoa privacy context – including the Privacy Act 2020 (NZ) – and consider the implications of te Tiriti o Waitangi and tikanga Māori for alternative privacy approaches. Future options, including legal and extra-legal measures, are proposed.

year: 2023