title: Supporting Focus and Context  Awareness in 3D Modeling Using  Multi-Layered Displays

authors: Mohd Yusof, Azmi

subjects: Focus and Context Awareness

abstract: Although advances in computer technology over the past few decades have made it possible to create and render highly realistic 3D models these days, the process of creating these models has remained largely unchanged over the years. Modern 3D modeling software provide a range of tools to assist users with creating 3D models, but the process of creating models in virtual 3D space is nevertheless still challenging and cumbersome. This thesis, therefore, aims to investigate whether it is possible to support modelers more effectively by providing them with alternative combinations of hardware and software tools to improve their 3D modeling tasks.
The first step towards achieving this goal has been to better understand the type of problems modelers face in using conventional 3D modeling software. To achieve this, a pilot study of novice 3D modelers, and a more comprehensive study of professional modelers were conducted. These studies resulted in identifying a range of focus and context awareness problems that modelers face in creating complex 3D models using conventional modeling software. These problems can be divided into four categories: maintaining position awareness, identifying and selecting objects or components of interest, recognizing the distance between objects or components, and realizing the relative position of objects or components.
Based on the above categorization, five focus and context awareness techniques were developed for a multi-layer computer display to enable modelers to better maintain their focus and context awareness while performing 3D modeling tasks. These techniques are: object isolation, component segregation, peeling focus, slicing, and peeling focus and context. 
A user study was then conducted to compare the effectiveness of these focus and context awareness techniques with other tools provided by conventional 3D modeling software. The results of this study were used to further improve, and evaluate through a second study, the five focus and context awareness techniques. The two studies have demonstrated that some of these techniques are more effective in supporting 3D modeling tasks than other existing software tools.

text: Supporting Focus and Context  Awareness in 3D Modeling Using  Multi-Layered Displays Although advances in computer technology over the past few decades have made it possible to create and render highly realistic 3D models these days, the process of creating these models has remained largely unchanged over the years. Modern 3D modeling software provide a range of tools to assist users with creating 3D models, but the process of creating models in virtual 3D space is nevertheless still challenging and cumbersome. This thesis, therefore, aims to investigate whether it is possible to support modelers more effectively by providing them with alternative combinations of hardware and software tools to improve their 3D modeling tasks.
The first step towards achieving this goal has been to better understand the type of problems modelers face in using conventional 3D modeling software. To achieve this, a pilot study of novice 3D modelers, and a more comprehensive study of professional modelers were conducted. These studies resulted in identifying a range of focus and context awareness problems that modelers face in creating complex 3D models using conventional modeling software. These problems can be divided into four categories: maintaining position awareness, identifying and selecting objects or components of interest, recognizing the distance between objects or components, and realizing the relative position of objects or components.
Based on the above categorization, five focus and context awareness techniques were developed for a multi-layer computer display to enable modelers to better maintain their focus and context awareness while performing 3D modeling tasks. These techniques are: object isolation, component segregation, peeling focus, slicing, and peeling focus and context. 
A user study was then conducted to compare the effectiveness of these focus and context awareness techniques with other tools provided by conventional 3D modeling software. The results of this study were used to further improve, and evaluate through a second study, the five focus and context awareness techniques. The two studies have demonstrated that some of these techniques are more effective in supporting 3D modeling tasks than other existing software tools.

year: 2013

title: pH-sensitive Anticancer Model Prodrug: Amide of Kemp's Acid

authors: Brooks, Robert Turongo

subjects: Anticancer Model prodrug

abstract: Solid tumours are characterised by lower extracellular pH (as low as 5.8 pH) compared to normal healthy cellular pH (actively regulated at pH 7.3). This difference may be exploited with an acid-sensitive anti-tumour prodrug which releases a cytotoxin selectively in tumour tissue.
The research reported in this thesis was aimed at synthesising and performing rate studies on an amide prodrug with pH-sensitive rates of reaction in the pH 5 - 8 region. Amide hydrolysis is catalysed by neighbouring carboxylic acid groups in their fully protonated state but not in its ionised state (shown in the figure below), whereby pH sensitivity around pH 5 - 8 can be exploited. The current study was carried out on an amide of Kemp's acid which, due to enforced stereochemistry of carboxylic acid and amide functional groups, has the type of structure conducive to accelerated amide hydrolysis.
The rates for tertiary and secondary aliphatic amides of this Kemp's acid system have shown high reactivity at low pH and a large reduction in rate across pH 5.8 - 7.3, however an aryl amide had not previously been studied. It was thought that an aryl amide of Kemp's acid would provide a faster rate of reaction compared with the alkyl amides, and also aryl amine cytotoxins exist which could be attached as an amide.
A secondary aryl amide of Kemp's acid (58) was obtained via a potassium hydroxide ring-opening reaction on a synthesised imide of Kemp's acid (43).
Aliquots of the ring-opened amide (58) were added to buffered (phosphate and malonate) aqueous solutions (with ionic strength μ = 1 mol L-1) and the hydrolysis reaction followed at 30.0 oC across the pH range 0.48 - 8. First order rate constants were calculated from absorbance change with time and the pH-rate profile established. Absorbance changes were shown to be consistent with amide hydrolysis with no evidence of any imide reformation as evident in other studies. The rate data were analysed. There was no evidence from rates for the two successive acid ionisations with only a single rate plateau evident from pH 2 to 5, suggesting that both
ONHCOOHCOO-OMe(58)
iv
di- and mono-acid species have very similar hydrolysis rates or that the second ionisation is low due to stabilisation of the mono-ionised molecule by hydrogen bonding interactions. For this reason, the rate profile could be analysed only as if it were a single ionisation in the same way that Menger and Ladika analysed their aliphatic tertiary pyrrolidyl amide in an earlier study. This analysis gave a pKa value of 6.72   0.09 and a limiting rate constant of 7.1 x 10-5 s-1. The studies revealed a three fold rate differential between pH 5.8 (faster) versus 7.3 (slower), a difference which is probably too small a selectivity for possible prodrug application.
Separately, the second order rate coefficient for the reaction of potassium hydroxide solution to open the imide was also established (k2 = 0.00067 L mol-1 s-1 at 30.0 oC, μ = 1.00 mol L-1 with KCl).

text: pH-sensitive Anticancer Model Prodrug: Amide of Kemp's Acid Solid tumours are characterised by lower extracellular pH (as low as 5.8 pH) compared to normal healthy cellular pH (actively regulated at pH 7.3). This difference may be exploited with an acid-sensitive anti-tumour prodrug which releases a cytotoxin selectively in tumour tissue.
The research reported in this thesis was aimed at synthesising and performing rate studies on an amide prodrug with pH-sensitive rates of reaction in the pH 5 - 8 region. Amide hydrolysis is catalysed by neighbouring carboxylic acid groups in their fully protonated state but not in its ionised state (shown in the figure below), whereby pH sensitivity around pH 5 - 8 can be exploited. The current study was carried out on an amide of Kemp's acid which, due to enforced stereochemistry of carboxylic acid and amide functional groups, has the type of structure conducive to accelerated amide hydrolysis.
The rates for tertiary and secondary aliphatic amides of this Kemp's acid system have shown high reactivity at low pH and a large reduction in rate across pH 5.8 - 7.3, however an aryl amide had not previously been studied. It was thought that an aryl amide of Kemp's acid would provide a faster rate of reaction compared with the alkyl amides, and also aryl amine cytotoxins exist which could be attached as an amide.
A secondary aryl amide of Kemp's acid (58) was obtained via a potassium hydroxide ring-opening reaction on a synthesised imide of Kemp's acid (43).
Aliquots of the ring-opened amide (58) were added to buffered (phosphate and malonate) aqueous solutions (with ionic strength μ = 1 mol L-1) and the hydrolysis reaction followed at 30.0 oC across the pH range 0.48 - 8. First order rate constants were calculated from absorbance change with time and the pH-rate profile established. Absorbance changes were shown to be consistent with amide hydrolysis with no evidence of any imide reformation as evident in other studies. The rate data were analysed. There was no evidence from rates for the two successive acid ionisations with only a single rate plateau evident from pH 2 to 5, suggesting that both
ONHCOOHCOO-OMe(58)
iv
di- and mono-acid species have very similar hydrolysis rates or that the second ionisation is low due to stabilisation of the mono-ionised molecule by hydrogen bonding interactions. For this reason, the rate profile could be analysed only as if it were a single ionisation in the same way that Menger and Ladika analysed their aliphatic tertiary pyrrolidyl amide in an earlier study. This analysis gave a pKa value of 6.72   0.09 and a limiting rate constant of 7.1 x 10-5 s-1. The studies revealed a three fold rate differential between pH 5.8 (faster) versus 7.3 (slower), a difference which is probably too small a selectivity for possible prodrug application.
Separately, the second order rate coefficient for the reaction of potassium hydroxide solution to open the imide was also established (k2 = 0.00067 L mol-1 s-1 at 30.0 oC, μ = 1.00 mol L-1 with KCl).

year: 2009

title: In their voice: Adult learners' perspectives on literacy and numeracy, learning and wellbeing

authors: Furness, Jane Amanda

abstract: In their voice: Adult learners’ perspectives on literacy and numeracy, learning and wellbeing (2023) reports on a case study undertaken in collaboration with Literacy Aotearoa. It has been undertaken as part of a larger project, The expression, experience and transcendence of low skill in Aotearoa New Zealand (2019–2024), the aim of which is to provide policy recommendations to improve life-course trajectories and socio-economic outcomes for adults with low literacy and/or numeracy (L+N) skills in Aotearoa New Zealand (Aotearoa). In their voice: Adult learners’ perspectives on literacy and numeracy, learning and wellbeing examines adults’ experiences as they navigate their lives and develop their L+N repertoire towards their aspirations for themselves and their families. Our focus is mainly on Māori (the Indigenous peoples of Aotearoa) adults.

The study has taken place at a time when adult L+N policy is at a crossroads in three senses. Policy over the last 23 years has only marginally improved L+N on the measures government uses with adults, yet it is known that wide-ranging, holistic benefits accrue from L+N education that values and embodies Māori interests and ways of being. Second, the most recent iteration of L+N policy expired in 2017 and is yet to be replaced, opening an opportunity for reconceptualisation and transformation of adult L+N policy. Third, Māori educators have articulated and demonstrated over decades the content and approaches for L+N learning that are of interest and value to Māori adults and whānau (immediate and extended family) but these remain by-and-large systemically unsupported. Nevertheless, government expectation is that all policy in Aotearoa account for wellbeing outcomes as set out in the ‘Living Standards Framework ‘and ‘He Ara Waiora’ (The Treasury, 2021, n. d.).

The standpoint for this study is that the Eurocentric perspective of literacy that predominates in adult L+N policy in Aotearoa – reading and writing alphabetic text, usually in English, and primarily for economic purposes – is inadequate in our bicultural nation. This narrow view of literacy and its purposes severely limits the extent to which Māori expectations for adult L+N education and for Māori prosperity are realised, contrary to the word and the spirit of Te Tiriti o Waitangi (The Treaty of Waitangi). Viewing literacy through sociocultural, sociomaterial, critical literacies and Indigenous lenses, the study makes a strong case for a much broader understanding of literacy and its purposes to decolonise adult L+N policy for the future. Supporting this aspiration, the study advances the notion of multiple meanings of literacy in which Māori perspectives are valued, upheld and promoted. Māori perspectives are understood as centring on whakapapa (genealogy) which provides the framework for connectedness of all things and is the basis for Māori identity and for comprehending and interpreting the world. 

The research process was informed by Kaupapa Māori (a Māori agenda) to the extent possible. Māori researchers conducted all but one interview and contributed to the thematic analysis of participants’ narratives. Two Pākehā researchers worked closely with the Māori team members and were guided by them. The specific approach for this case study was co-designed with Literacy Aotearoa to ensure participants’ needs and aspirations in the research were met. Twenty adults (15 Māori, one Samoan and four Pākehā) graciously agreed to share their insights and were interviewed individually, in pairs or in a focus group according to their choice. They were aged from early 20s to late 60s and varied in their qualifications and learning challenges. The same number of men and women took part. The following questions directed the interviews and focus groups:

1. What has motivated people/whānau to make change in their lives?
2. What was the pathway that people/whānau have taken to make change in their lives? 
3. What are people’s experiences of their efforts to make change in their lives? 
4. What have been supports or facilitators, barriers or challenges in their efforts? 

The narrative transcripts were analysed from a critical sociocultural and strengths-based standpoint. Findings were described and discussed in relation to the following broad thematic categories:

 1. What matters to people in their lives – views of wellbeing, values and aspirations
 2. Learning and life pathways – experiences of learning, schooling and post school
 3. What enables people to live the lives they choose
 4. What makes it harder for people to live the lives they choose

The study shows the centrality of te ao Māori (Māori worldview) in the lives of Māori adults and whānau. It is fundamental to Māori identity and wellbeing and remains throughout their lives even when they have experienced periods of disconnection. Enacted valuing of te ao Māori within the programmes enabled participants to feel safe to be who they are, excited about their L+N learning, and looking forward to meaningful outcomes for themselves and their whānau despite the oft-present anxiety about returning to a classroom. Relatedly, prioritising the wellbeing of the learners through caring and respectful learning environments is crucial to coming to and staying in L+N learning opportunities which can then provide an opportunity to transcend hurtful past learning experiences and enable participants to see themselves as capable learners and contributing adults in the world. These characteristics of the participants’ learning experiences in the study programmes reflected values and ways of being fundamental to being Māori which meant the dissonance often experienced in other learning settings was not present and participants could enjoy learning what and how was important to them.

The study notes that L+N in the Eurocentric meaning was addressed in the L+N programmes our participants attended (for example digital skills for work were taught) but the programmes simultaneously embodied broader meanings and purposes of literacy that are not typically foregrounded in L+N policy in Aotearoa. The study contends that the enactment in the programmes of Māori values and ways of being and doing allowed transformative learning to occur, not just for the Māori learners but for everyone. The study demonstrated that L+N learning valued by learners themselves is best defined as the acquisition of knowledge and skills that have meaning and are useful in their lives, can contribute to better lives for whānau, hapū and iwi and can be passed on to future generations. Defined from this viewpoint, valued L+N includes matauranga Māori (Māori knowledge) and Māori cultural practices, values and language; foundational skills and knowledge in English missed at school; and specific skills for changing times including work and everyday personal, family and community life that centres whānau (family and extended family) wellbeing.

The study calls for a change in the definition and rationalisation embedded in current (though expired) adult L+N policy from a narrow economy-focused approach to a broad and culturally inclusive definition and rationalisation. This requires detachment from a singular view of what literacy is to a view of literacy as a multiple construct; in other words, seeing literacy as having many meanings. Accompanying this embrace of literacies, Māori perspectives of L+N must move from the margins of adult L+N policy to the centre, led by Māori.

text: In their voice: Adult learners' perspectives on literacy and numeracy, learning and wellbeing In their voice: Adult learners’ perspectives on literacy and numeracy, learning and wellbeing (2023) reports on a case study undertaken in collaboration with Literacy Aotearoa. It has been undertaken as part of a larger project, The expression, experience and transcendence of low skill in Aotearoa New Zealand (2019–2024), the aim of which is to provide policy recommendations to improve life-course trajectories and socio-economic outcomes for adults with low literacy and/or numeracy (L+N) skills in Aotearoa New Zealand (Aotearoa). In their voice: Adult learners’ perspectives on literacy and numeracy, learning and wellbeing examines adults’ experiences as they navigate their lives and develop their L+N repertoire towards their aspirations for themselves and their families. Our focus is mainly on Māori (the Indigenous peoples of Aotearoa) adults.

The study has taken place at a time when adult L+N policy is at a crossroads in three senses. Policy over the last 23 years has only marginally improved L+N on the measures government uses with adults, yet it is known that wide-ranging, holistic benefits accrue from L+N education that values and embodies Māori interests and ways of being. Second, the most recent iteration of L+N policy expired in 2017 and is yet to be replaced, opening an opportunity for reconceptualisation and transformation of adult L+N policy. Third, Māori educators have articulated and demonstrated over decades the content and approaches for L+N learning that are of interest and value to Māori adults and whānau (immediate and extended family) but these remain by-and-large systemically unsupported. Nevertheless, government expectation is that all policy in Aotearoa account for wellbeing outcomes as set out in the ‘Living Standards Framework ‘and ‘He Ara Waiora’ (The Treasury, 2021, n. d.).

The standpoint for this study is that the Eurocentric perspective of literacy that predominates in adult L+N policy in Aotearoa – reading and writing alphabetic text, usually in English, and primarily for economic purposes – is inadequate in our bicultural nation. This narrow view of literacy and its purposes severely limits the extent to which Māori expectations for adult L+N education and for Māori prosperity are realised, contrary to the word and the spirit of Te Tiriti o Waitangi (The Treaty of Waitangi). Viewing literacy through sociocultural, sociomaterial, critical literacies and Indigenous lenses, the study makes a strong case for a much broader understanding of literacy and its purposes to decolonise adult L+N policy for the future. Supporting this aspiration, the study advances the notion of multiple meanings of literacy in which Māori perspectives are valued, upheld and promoted. Māori perspectives are understood as centring on whakapapa (genealogy) which provides the framework for connectedness of all things and is the basis for Māori identity and for comprehending and interpreting the world. 

The research process was informed by Kaupapa Māori (a Māori agenda) to the extent possible. Māori researchers conducted all but one interview and contributed to the thematic analysis of participants’ narratives. Two Pākehā researchers worked closely with the Māori team members and were guided by them. The specific approach for this case study was co-designed with Literacy Aotearoa to ensure participants’ needs and aspirations in the research were met. Twenty adults (15 Māori, one Samoan and four Pākehā) graciously agreed to share their insights and were interviewed individually, in pairs or in a focus group according to their choice. They were aged from early 20s to late 60s and varied in their qualifications and learning challenges. The same number of men and women took part. The following questions directed the interviews and focus groups:

1. What has motivated people/whānau to make change in their lives?
2. What was the pathway that people/whānau have taken to make change in their lives? 
3. What are people’s experiences of their efforts to make change in their lives? 
4. What have been supports or facilitators, barriers or challenges in their efforts? 

The narrative transcripts were analysed from a critical sociocultural and strengths-based standpoint. Findings were described and discussed in relation to the following broad thematic categories:

 1. What matters to people in their lives – views of wellbeing, values and aspirations
 2. Learning and life pathways – experiences of learning, schooling and post school
 3. What enables people to live the lives they choose
 4. What makes it harder for people to live the lives they choose

The study shows the centrality of te ao Māori (Māori worldview) in the lives of Māori adults and whānau. It is fundamental to Māori identity and wellbeing and remains throughout their lives even when they have experienced periods of disconnection. Enacted valuing of te ao Māori within the programmes enabled participants to feel safe to be who they are, excited about their L+N learning, and looking forward to meaningful outcomes for themselves and their whānau despite the oft-present anxiety about returning to a classroom. Relatedly, prioritising the wellbeing of the learners through caring and respectful learning environments is crucial to coming to and staying in L+N learning opportunities which can then provide an opportunity to transcend hurtful past learning experiences and enable participants to see themselves as capable learners and contributing adults in the world. These characteristics of the participants’ learning experiences in the study programmes reflected values and ways of being fundamental to being Māori which meant the dissonance often experienced in other learning settings was not present and participants could enjoy learning what and how was important to them.

The study notes that L+N in the Eurocentric meaning was addressed in the L+N programmes our participants attended (for example digital skills for work were taught) but the programmes simultaneously embodied broader meanings and purposes of literacy that are not typically foregrounded in L+N policy in Aotearoa. The study contends that the enactment in the programmes of Māori values and ways of being and doing allowed transformative learning to occur, not just for the Māori learners but for everyone. The study demonstrated that L+N learning valued by learners themselves is best defined as the acquisition of knowledge and skills that have meaning and are useful in their lives, can contribute to better lives for whānau, hapū and iwi and can be passed on to future generations. Defined from this viewpoint, valued L+N includes matauranga Māori (Māori knowledge) and Māori cultural practices, values and language; foundational skills and knowledge in English missed at school; and specific skills for changing times including work and everyday personal, family and community life that centres whānau (family and extended family) wellbeing.

The study calls for a change in the definition and rationalisation embedded in current (though expired) adult L+N policy from a narrow economy-focused approach to a broad and culturally inclusive definition and rationalisation. This requires detachment from a singular view of what literacy is to a view of literacy as a multiple construct; in other words, seeing literacy as having many meanings. Accompanying this embrace of literacies, Māori perspectives of L+N must move from the margins of adult L+N policy to the centre, led by Māori.

year: 2023