title: Neurostimulation artefact minimisation

authors: Single, Peter Scott Vallack

abstract: A neurostimulation device has a stimulus, and a position of a measurement electrode relative to the stimulus, configured such that in artefact as arising relative to distance from the stimulus electrode a minima region of the artefact is substantially co-located with the measurement electrode. Or, a ratio of the inter-electrode spacing to the electrode length is between 2 and 3.66. Or, an impedance is connected to a passive electrode and is configured to reduce artefact arising on the measurement electrode.

text: Neurostimulation artefact minimisation A neurostimulation device has a stimulus, and a position of a measurement electrode relative to the stimulus, configured such that in artefact as arising relative to distance from the stimulus electrode a minima region of the artefact is substantially co-located with the measurement electrode. Or, a ratio of the inter-electrode spacing to the electrode length is between 2 and 3.66. Or, an impedance is connected to a passive electrode and is configured to reduce artefact arising on the measurement electrode.

year: 2020

title: Repetitive Transcranial Magnetic Stimulation: A Call for Better Data

authors: Wilson, Marcus T.

subjects: Science & Technology

abstract: Repetitive Transcranial Magnetic Stimulation (rTMS) is increasingly used to treat stroke, Parkinson's disease and depression (Fregni et al., 2005; Loo and Mitchell, 2005; Hallet, 2007; O'Reardon et al., 2007; Ridding and Rothwell, 2007). rTMS uses bursts of magnetic pulses to change the excitability and connection strengths of cortical neurons. However, the evidence to inform clinical application is highly inconsistent (Thut and Pascual-Leone, 2010; Hamada et al., 2013) and substantially based on trial and error. Systematic theory is lacking. Typically, in rTMS research, measurements of motor-evoked potential (MEP) are made, often in terms of the strength of the MEP and the length of the cortical silent period that follows. However, the MEP is probably a poor and certainly an indirect measure of changes in the brain (Nicolo et al., 2015), clouding our understanding of rTMS mechanisms. In practice, therefore, particular amplitudes and timing of pulses in an rTMS sequence are selected because they show promise in small subsets of people. However, even basics such as the sign of any change in the outcome measure (e.g., does the MEP increase or decrease?) is debated. Many results show a wide spread in responses. It has become common to talk about “responders” and “non-responders” although evidence for a binary distinction in these two groups is lacking—in reality there is usually a continuum of response often including potentiation in some and depression in others (Nettekoven et al., 2015). Moreover, Héroux et al. (2015) provide evidence that the irreproducibility of results may be due to small sample sizes, unscientific screening of subjects and data, and selective reporting of results.

text: Repetitive Transcranial Magnetic Stimulation: A Call for Better Data Repetitive Transcranial Magnetic Stimulation (rTMS) is increasingly used to treat stroke, Parkinson's disease and depression (Fregni et al., 2005; Loo and Mitchell, 2005; Hallet, 2007; O'Reardon et al., 2007; Ridding and Rothwell, 2007). rTMS uses bursts of magnetic pulses to change the excitability and connection strengths of cortical neurons. However, the evidence to inform clinical application is highly inconsistent (Thut and Pascual-Leone, 2010; Hamada et al., 2013) and substantially based on trial and error. Systematic theory is lacking. Typically, in rTMS research, measurements of motor-evoked potential (MEP) are made, often in terms of the strength of the MEP and the length of the cortical silent period that follows. However, the MEP is probably a poor and certainly an indirect measure of changes in the brain (Nicolo et al., 2015), clouding our understanding of rTMS mechanisms. In practice, therefore, particular amplitudes and timing of pulses in an rTMS sequence are selected because they show promise in small subsets of people. However, even basics such as the sign of any change in the outcome measure (e.g., does the MEP increase or decrease?) is debated. Many results show a wide spread in responses. It has become common to talk about “responders” and “non-responders” although evidence for a binary distinction in these two groups is lacking—in reality there is usually a continuum of response often including potentiation in some and depression in others (Nettekoven et al., 2015). Moreover, Héroux et al. (2015) provide evidence that the irreproducibility of results may be due to small sample sizes, unscientific screening of subjects and data, and selective reporting of results.

year: 2016

title: Māori women’s perspectives of leadership and wellbeing

authors: Ruru, Stacey Mariu

subjects: Māori leadership

abstract: Within Aotearoa, New Zealand, Māori women are engaged in leadership roles in community and professional workplace settings, however little is known about how they maintain their wellbeing. This research sought to unravel how Māori women leaders maintain their wellbeing, while occupied in complex leadership roles. We report on the findings from semi-structured interviews, acknowledging kaupapa Māori theory and principles, with five Māori women leaders. Thematic analysis was used, and these themes related to five whakataukī (proverb) that provided overarching themes and directions relating to Māori women’s leadership and wellbeing. Each whakataukī describe unique aspects of leadership and wellbeing from a Māori worldview. Themes include humility, collectiveness, courage, future orientations and positivity. While the themes are housed in whakataukī, central to the success of these Māori women leaders was being connected to whānau (family) and friends, and being influenced by tamariki (children), tauira (students) and employees. These social connections made Māori women leaders strong and resilient to change and challenges.

text: Māori women’s perspectives of leadership and wellbeing Within Aotearoa, New Zealand, Māori women are engaged in leadership roles in community and professional workplace settings, however little is known about how they maintain their wellbeing. This research sought to unravel how Māori women leaders maintain their wellbeing, while occupied in complex leadership roles. We report on the findings from semi-structured interviews, acknowledging kaupapa Māori theory and principles, with five Māori women leaders. Thematic analysis was used, and these themes related to five whakataukī (proverb) that provided overarching themes and directions relating to Māori women’s leadership and wellbeing. Each whakataukī describe unique aspects of leadership and wellbeing from a Māori worldview. Themes include humility, collectiveness, courage, future orientations and positivity. While the themes are housed in whakataukī, central to the success of these Māori women leaders was being connected to whānau (family) and friends, and being influenced by tamariki (children), tauira (students) and employees. These social connections made Māori women leaders strong and resilient to change and challenges.

year: 2017