title: The positive effects of negative information: Extending one-class classification models in binary proteomic sequence classification

authors: Mutter, Stefan

subjects: computer science

abstract: Profile Hidden Markov Models (PHMMs) have been widely used as models for Multiple Sequence Alignments. By their nature, they are generative one-class classifiers trained only on sequences belonging to the target class they represent. Nevertheless, they are often used to discriminate between classes. In this paper, we investigate the beneficial effects of information from non-target classes in discriminative tasks. Firstly, the traditional PHMM is extended to a new binary classifier. Secondly, we propose propositional representations of the original PHMM that capture information from target and non-target sequences and can be used with standard binary classifiers. Since PHMM training is time intensive, we investigate whether our approach allows the training of the PHMM to stop, before it is fully converged, without loss of predictive power.

text: The positive effects of negative information: Extending one-class classification models in binary proteomic sequence classification Profile Hidden Markov Models (PHMMs) have been widely used as models for Multiple Sequence Alignments. By their nature, they are generative one-class classifiers trained only on sequences belonging to the target class they represent. Nevertheless, they are often used to discriminate between classes. In this paper, we investigate the beneficial effects of information from non-target classes in discriminative tasks. Firstly, the traditional PHMM is extended to a new binary classifier. Secondly, we propose propositional representations of the original PHMM that capture information from target and non-target sequences and can be used with standard binary classifiers. Since PHMM training is time intensive, we investigate whether our approach allows the training of the PHMM to stop, before it is fully converged, without loss of predictive power.

year: 2009

title: Abstracts of the 7th International Conference on Lactoferrin / Résumés de la 7e Conférence internationale sur la lactoferrine

authors: Thomson, N.A.

subjects: lactoferrins

abstract: The article presents abstracts on lactoferrin research. They include "Oral administration of lactoferrin raises NK cell activity in mice,"Comparison of antimicrobial activity between lactoferricin B 15 derivative and antibiotics" and "Batch extraction of lactoferrin from raw whole milk."

text: Abstracts of the 7th International Conference on Lactoferrin / Résumés de la 7e Conférence internationale sur la lactoferrine The article presents abstracts on lactoferrin research. They include "Oral administration of lactoferrin raises NK cell activity in mice,"Comparison of antimicrobial activity between lactoferricin B 15 derivative and antibiotics" and "Batch extraction of lactoferrin from raw whole milk."

year: 2006-06

title: Rumours of gold at Te Aroha

authors: Hart, Philip

abstract: From the time of the opening of the Thames goldfield, miners were tormented by the belief that the best gold would be found in Te Aroha mountain, on their southern horizon - so near and yet so far because of Maori resistance to prospecting that district. Some Maori claimed to have found gold there, and visiting Pakeha from at least the 1850s onwards detected gold in the vicinity. The first time gold in the Waiorongomai valley was noted was in 1868. Several prospectors claimed to have explored the district, illegally and, potentially, dangerously, especially after Ohinemuri was opened to mining in 1875. But not until Hone Werahiko found gold in 1880 and the field was officially opened on 25 November would it be possible to prove whether a payable goldfield existed.

text: Rumours of gold at Te Aroha From the time of the opening of the Thames goldfield, miners were tormented by the belief that the best gold would be found in Te Aroha mountain, on their southern horizon - so near and yet so far because of Maori resistance to prospecting that district. Some Maori claimed to have found gold there, and visiting Pakeha from at least the 1850s onwards detected gold in the vicinity. The first time gold in the Waiorongomai valley was noted was in 1868. Several prospectors claimed to have explored the district, illegally and, potentially, dangerously, especially after Ohinemuri was opened to mining in 1875. But not until Hone Werahiko found gold in 1880 and the field was officially opened on 25 November would it be possible to prove whether a payable goldfield existed.

year: 2016