title: A general method for the synthesis of peptidyl substrate for proteolytic enzymes

authors: Whitmore, Andrew

subjects: biology

abstract: The synthesis of an heterogeneous peptide substrate for the assay of proteases was carried out by cleaving a protein using a protease to generate small peptides which were then coupled to a chromophore, p-nitroaniline. The chromophoric peptide product could be used to assay for the protease which produced the original peptides.

text: A general method for the synthesis of peptidyl substrate for proteolytic enzymes The synthesis of an heterogeneous peptide substrate for the assay of proteases was carried out by cleaving a protein using a protease to generate small peptides which were then coupled to a chromophore, p-nitroaniline. The chromophoric peptide product could be used to assay for the protease which produced the original peptides.

year: 1995

title: A linear programming approach to fitting rainfall runoff models based on finite mixture hydrographs: a potential for flood forecasting?

authors: Bardsley, W. Earl

subjects: linear programming

abstract: It is recognised that the transformation of rainfall to discharge is essentially nonlinear and it would seem logical to construct parsimonious nonlinear models to approximate the runoff process. Lumped nonlinear rainfall-runoff models are simple to construct but difficulties may be created in the calibration process if suboptimal fits to data arise from local minima in the objective function measuring goodness of fit, where small fit values indicate improved fit.

text: A linear programming approach to fitting rainfall runoff models based on finite mixture hydrographs: a potential for flood forecasting? It is recognised that the transformation of rainfall to discharge is essentially nonlinear and it would seem logical to construct parsimonious nonlinear models to approximate the runoff process. Lumped nonlinear rainfall-runoff models are simple to construct but difficulties may be created in the calibration process if suboptimal fits to data arise from local minima in the objective function measuring goodness of fit, where small fit values indicate improved fit.

year: 2007

title: The COVID-19 domestic vaccine pass: Implications for Māori

authors: Kukutai, Tahu

abstract: The New Zealand government has introduced a COVID-19 domestic vaccine pass to be used in conjunction with the COVID-19 Protection Framework. The Framework is likely to be activated soon after Cabinet meets on 29 November 2021. The pass will be necessary to access places and events that require proof of vaccination under the Framework.
This brief does not argue for or against the introduction of a domestic vaccine pass, but rather discusses key issues that it raises for Māori, and suggests actions to address them. We see four key issues:
• the lack of Māori involvement, as a Tiriti partner, on either the design or implementation of the COVID-19 domestic vaccine pass;
• disproportionate restriction on Māori mobility due to lower Māori vaccination rates;
• privacy and data security concerns;
• uneven implementation that could increase discrimination against Māori and other groups considered to pose a risk to others’ safety.
To respond to these issues we recommend that the implementation of the pass be designed in partnership with Māori and comply with Māori data sovereignty requirements. As Tiriti partners, Māori should expect that the pass will keep their communities safe, while providing opportunities to enact manaakitanga in the matrix of care, and the mana to manage their own affairs.

text: The COVID-19 domestic vaccine pass: Implications for Māori The New Zealand government has introduced a COVID-19 domestic vaccine pass to be used in conjunction with the COVID-19 Protection Framework. The Framework is likely to be activated soon after Cabinet meets on 29 November 2021. The pass will be necessary to access places and events that require proof of vaccination under the Framework.
This brief does not argue for or against the introduction of a domestic vaccine pass, but rather discusses key issues that it raises for Māori, and suggests actions to address them. We see four key issues:
• the lack of Māori involvement, as a Tiriti partner, on either the design or implementation of the COVID-19 domestic vaccine pass;
• disproportionate restriction on Māori mobility due to lower Māori vaccination rates;
• privacy and data security concerns;
• uneven implementation that could increase discrimination against Māori and other groups considered to pose a risk to others’ safety.
To respond to these issues we recommend that the implementation of the pass be designed in partnership with Māori and comply with Māori data sovereignty requirements. As Tiriti partners, Māori should expect that the pass will keep their communities safe, while providing opportunities to enact manaakitanga in the matrix of care, and the mana to manage their own affairs.

year: 2021-11-30