title: Implementation of Nepal’s Education Policy in ICT: Examining current practice through an Ecological Model

authors: Rana, Karna

abstract: Educational policy implementation can be conceptualised in terms of an ecological model that explores roles and relationships within a complex evolving environment. This article draws on an ecological model to examine Nepal's implementation of its policy for information and communication technology in education. The policy is developed by government and mandated to schools, but government does not commit funding to resource infrastructures or train teachers in information and communication technology (ICT) use. Instead, nongovernment organisations (NGOs) have stepped in and provided resources and training. Thus, two separate systems have evolved. This article examines their actions and interactions as components within an ecology. It utilises a methodological approach that involves qualitative case studies of particular rural schools, analysed through interpretive phenomenological analysis and the lens of an ecology model. It reports findings of how a largely symbiotic relationship has evolved that is somewhat successful in meeting immediate needs and examines changes that are developing in the ecology and that may impact on the future of ICT implementation in Nepal. The study contributes to practical understanding of the potentially symbiotic roles of NGOs and government in ICT provision to rural schools in Nepal. It further contributes to ways policy implementation in developing countries may be theorised.

text: Implementation of Nepal’s Education Policy in ICT: Examining current practice through an Ecological Model Educational policy implementation can be conceptualised in terms of an ecological model that explores roles and relationships within a complex evolving environment. This article draws on an ecological model to examine Nepal's implementation of its policy for information and communication technology in education. The policy is developed by government and mandated to schools, but government does not commit funding to resource infrastructures or train teachers in information and communication technology (ICT) use. Instead, nongovernment organisations (NGOs) have stepped in and provided resources and training. Thus, two separate systems have evolved. This article examines their actions and interactions as components within an ecology. It utilises a methodological approach that involves qualitative case studies of particular rural schools, analysed through interpretive phenomenological analysis and the lens of an ecology model. It reports findings of how a largely symbiotic relationship has evolved that is somewhat successful in meeting immediate needs and examines changes that are developing in the ecology and that may impact on the future of ICT implementation in Nepal. The study contributes to practical understanding of the potentially symbiotic roles of NGOs and government in ICT provision to rural schools in Nepal. It further contributes to ways policy implementation in developing countries may be theorised.

year: 2019

title: Identification and functional characterization of a new IL-1 family member, IL-1Fm2, in most evolutionarily advanced fish

authors: Angosto, Diego

subjects: Inflammation

abstract: The IL-1 family consists of 11 members that play an important role as key mediators in inflammation and immunity. Here, we report the identification of a new member of the IL-1 family (IL-1Fm2) that is present in species belonging to the most evolutionarily advanced group of teleost fish (Series Percomorpha), including Perciformes, Beloniformes, Gasterosteiformes, Cyprinodontiformes and Pleuronectiformes. However, IL-1Fm2 seems to be absent in Tetraodontiformes, which also belong to the Percomorpha. The expression pattern of gilthead seabream IL-1Fm2 revealed that although it was hardly induced by PAMPs, the combination of PAMPs and recombinant IL-1Fm2 synergistically induced its expression in macrophages and granulocytes. In addition, recombinant IL-1Fm2 was able to activate the respiratory burst of seabream phagocytes and to synergistically induce the expression of IL-1β, TNF-α, IL-8 and IL-10 when combined with PAMPs. Finally, although gilthead seabream IL-1Fm2 did not show a conserved caspase-1 processing site, macrophages processed IL-1Fm2 before being released. However, both pan-caspase and caspase-1 inhibitors failed to inhibit the processing and release of IL-1Fm2. These results demonstrate an important role of IL-1Fm2 in the regulation of fish immune responses, shed light on the evolution of the IL-1 family in vertebrates and point to the complexity of this cytokine family.

text: Identification and functional characterization of a new IL-1 family member, IL-1Fm2, in most evolutionarily advanced fish The IL-1 family consists of 11 members that play an important role as key mediators in inflammation and immunity. Here, we report the identification of a new member of the IL-1 family (IL-1Fm2) that is present in species belonging to the most evolutionarily advanced group of teleost fish (Series Percomorpha), including Perciformes, Beloniformes, Gasterosteiformes, Cyprinodontiformes and Pleuronectiformes. However, IL-1Fm2 seems to be absent in Tetraodontiformes, which also belong to the Percomorpha. The expression pattern of gilthead seabream IL-1Fm2 revealed that although it was hardly induced by PAMPs, the combination of PAMPs and recombinant IL-1Fm2 synergistically induced its expression in macrophages and granulocytes. In addition, recombinant IL-1Fm2 was able to activate the respiratory burst of seabream phagocytes and to synergistically induce the expression of IL-1β, TNF-α, IL-8 and IL-10 when combined with PAMPs. Finally, although gilthead seabream IL-1Fm2 did not show a conserved caspase-1 processing site, macrophages processed IL-1Fm2 before being released. However, both pan-caspase and caspase-1 inhibitors failed to inhibit the processing and release of IL-1Fm2. These results demonstrate an important role of IL-1Fm2 in the regulation of fish immune responses, shed light on the evolution of the IL-1 family in vertebrates and point to the complexity of this cytokine family.

year: 2013

title: The city of Rotorua and its meaning to Ngati Whakaue

authors: Te Awekotuku, Ngahuia

subjects: New Zealand

abstract: This paper discusses the history and settlement of the city of Rotorua as it relates to Ngati Whakaue.

text: The city of Rotorua and its meaning to Ngati Whakaue This paper discusses the history and settlement of the city of Rotorua as it relates to Ngati Whakaue.

year: 1976-08