title: The NLANR NAI Network Analysis Infrastructure

authors: McGregor, Anthony James

subjects: monitoring

abstract: The National Laboratory for Applied Network Research is creating a network analysis infrastructure to support network research and engineering of high performance research networks. The NAI includes a passive monitoring project, an active monitoring project, and collection of network management and control data. Together these projects have deployed more than 120 monitors around the high-performance research networks in the United States. This article describes NAI and the projects using it. The article concludes with a discussion of the future plans for the infrastructure.

text: The NLANR NAI Network Analysis Infrastructure The National Laboratory for Applied Network Research is creating a network analysis infrastructure to support network research and engineering of high performance research networks. The NAI includes a passive monitoring project, an active monitoring project, and collection of network management and control data. Together these projects have deployed more than 120 monitors around the high-performance research networks in the United States. This article describes NAI and the projects using it. The article concludes with a discussion of the future plans for the infrastructure.

year: 2000

title: Identification of central mechanisms underlying statin-induced changes in consummatory behaviour in rats

authors: Isgrove, Kiriana

subjects: simvastatin

abstract: Simvastatin is a cholesterol lowering statin whose adverse effects include an increase in appetite and, consequently, obesity. This is counterproductive to the otherwise beneficial outcomes of simvastatin on metabolic and cardiovascular health. The mechanisms underlying simvastatin-induced hyperphagia are unknown. This thesis investigated by using a laboratory rat model whether central mechanisms contribute to simvastatin-induced increase in appetite. First, the effect of intracerebroventricularly (ICV) administered simvastatin on the energy-driven intake of ‘bland’ chow, and on reward-motivated consumption of palatable solutions, was determined. The data indicate that ICV simvastatin moderately increases ingestion of energy-dense chow, but it does not affect consumption of calorie-dilute and non-caloric palatable sucrose or saccharin solutions. It suggests that simvastatin acting directly at the brain level elevates intake of energy, while being ineffective in stimulating eating for reward. Surprisingly, rats injected ICV with this statin consume also significantly more water after water deprivation, which points to a relationship between centrally acting simvastatin and thirst-related processing. In the second part of this project, the effect of the orexigenic dose of ICV simvastatin on neuronal activation in consumption-related hypothalamic sites was investigated. Simvastatin elevated c-Fos immunoreactivity, which serves as a marker of neuronal activation, in the arcuate and paraventricular nuclei, two sites that have a profound influence on the regulation of energy intake and energy balance, as well as affect water balance. It can be concluded that simvastatin increases intake of energy and of water, and that it likely exerts its action through the hypothalamic paraventricular and arcuate nuclei.

text: Identification of central mechanisms underlying statin-induced changes in consummatory behaviour in rats Simvastatin is a cholesterol lowering statin whose adverse effects include an increase in appetite and, consequently, obesity. This is counterproductive to the otherwise beneficial outcomes of simvastatin on metabolic and cardiovascular health. The mechanisms underlying simvastatin-induced hyperphagia are unknown. This thesis investigated by using a laboratory rat model whether central mechanisms contribute to simvastatin-induced increase in appetite. First, the effect of intracerebroventricularly (ICV) administered simvastatin on the energy-driven intake of ‘bland’ chow, and on reward-motivated consumption of palatable solutions, was determined. The data indicate that ICV simvastatin moderately increases ingestion of energy-dense chow, but it does not affect consumption of calorie-dilute and non-caloric palatable sucrose or saccharin solutions. It suggests that simvastatin acting directly at the brain level elevates intake of energy, while being ineffective in stimulating eating for reward. Surprisingly, rats injected ICV with this statin consume also significantly more water after water deprivation, which points to a relationship between centrally acting simvastatin and thirst-related processing. In the second part of this project, the effect of the orexigenic dose of ICV simvastatin on neuronal activation in consumption-related hypothalamic sites was investigated. Simvastatin elevated c-Fos immunoreactivity, which serves as a marker of neuronal activation, in the arcuate and paraventricular nuclei, two sites that have a profound influence on the regulation of energy intake and energy balance, as well as affect water balance. It can be concluded that simvastatin increases intake of energy and of water, and that it likely exerts its action through the hypothalamic paraventricular and arcuate nuclei.

year: 2017

title: Tāwharautia Aotearoa

authors: Maxwell, Te Kahautu

abstract: Tāwharautia Aotearoa was composed in opposition to the National Governments attempt to remove Section 9 of the Principles of the Treaty of Waitangi which would give the Government power to sell State assets. Performed by Ōpōtiki Mai Tawhiti at the Te Matatini World Championship Kapa Haa Competition 2013.

text: Tāwharautia Aotearoa Tāwharautia Aotearoa was composed in opposition to the National Governments attempt to remove Section 9 of the Principles of the Treaty of Waitangi which would give the Government power to sell State assets. Performed by Ōpōtiki Mai Tawhiti at the Te Matatini World Championship Kapa Haa Competition 2013.

year: 2013