title: Review: A new understanding of how temperature affects the catalytic activity of enzymes

authors: Daniel, Roy M.

subjects: enzyme

abstract: The two established thermal properties of enzymes are their activation energy and their thermal stability, but experimental data do not match the expectations of these two properties. The recently proposed Equilibrium Model (EM) provides a quantitative explanation of enzyme thermal behaviour under reaction conditions by introducing an inactive (but not denatured) intermediate in rapid equilibrium with the active form. It was formulated as a mathematical model, and fits the known experimental data. Importantly, the EM gives rise to a number of new insights into the molecular basis of the temperature control of enzymes and their environmental adaptation and evolution, it is consistent with active site properties, and it has fundamental implications for enzyme engineering and other areas of biotechnology.

text: Review: A new understanding of how temperature affects the catalytic activity of enzymes The two established thermal properties of enzymes are their activation energy and their thermal stability, but experimental data do not match the expectations of these two properties. The recently proposed Equilibrium Model (EM) provides a quantitative explanation of enzyme thermal behaviour under reaction conditions by introducing an inactive (but not denatured) intermediate in rapid equilibrium with the active form. It was formulated as a mathematical model, and fits the known experimental data. Importantly, the EM gives rise to a number of new insights into the molecular basis of the temperature control of enzymes and their environmental adaptation and evolution, it is consistent with active site properties, and it has fundamental implications for enzyme engineering and other areas of biotechnology.

year: 2010

title: Building a public digital library based on full-text retrieval

authors: Witten, Ian H.

subjects: computer science

abstract: Digital libraries are expensive to create and maintain, and generally restricted to a particular corporation or group of paying subscribers. While many indexes to the World Wide Web are freely available, the quality of what is indexed is extremely uneven. The digital analog of a public library a reliable, quality, community service has yet to appear. This paper demonstrates the feasibility of a cost-effective collection of high-quality public-domain information, available free over the Internet. One obstacle to the creation of a digital library is the difficulty of providing formal cataloguing information. Without a title, author and subject database it seems hard to offer the searching facilities normally available in physical libraries. Full-text retrieval provides a way of approximating these services without a concomitant investment of resources. A second is the problem of finding a suitable corpus of material. Computer science research reports form the focus of our prototype implementation. These constitute a large body of high-quality public-domain documents. Given such a corpus, a third issue becomes the question of obtaining both plain text for indexing, and page images for readability. Typesetting formats such as PostScript provide some of the benefits of libraries scanned from paper documents such as paged-based indexing and viewing without the physical demands and error-prone nature of scanning and optical character recognition. However, until recently the difficulty of extracting text from PostScript seems to have encouraged indexing on plain-text abstracts or bibliographic information provided by authors. We have developed a new technique that overcomes the problem. This paper describes the architecture, the indexing, collection and maintenance processes, and the retrieval interface, to a prototype public digital library.

text: Building a public digital library based on full-text retrieval Digital libraries are expensive to create and maintain, and generally restricted to a particular corporation or group of paying subscribers. While many indexes to the World Wide Web are freely available, the quality of what is indexed is extremely uneven. The digital analog of a public library a reliable, quality, community service has yet to appear. This paper demonstrates the feasibility of a cost-effective collection of high-quality public-domain information, available free over the Internet. One obstacle to the creation of a digital library is the difficulty of providing formal cataloguing information. Without a title, author and subject database it seems hard to offer the searching facilities normally available in physical libraries. Full-text retrieval provides a way of approximating these services without a concomitant investment of resources. A second is the problem of finding a suitable corpus of material. Computer science research reports form the focus of our prototype implementation. These constitute a large body of high-quality public-domain documents. Given such a corpus, a third issue becomes the question of obtaining both plain text for indexing, and page images for readability. Typesetting formats such as PostScript provide some of the benefits of libraries scanned from paper documents such as paged-based indexing and viewing without the physical demands and error-prone nature of scanning and optical character recognition. However, until recently the difficulty of extracting text from PostScript seems to have encouraged indexing on plain-text abstracts or bibliographic information provided by authors. We have developed a new technique that overcomes the problem. This paper describes the architecture, the indexing, collection and maintenance processes, and the retrieval interface, to a prototype public digital library.

year: 1995-08

title: Indigidata Aotearoa post-event summary report 2023

authors: Te Kotahi Research Institute

subjects: Indigenous Data Sovereignty

abstract: From the 21st to the 24th of August, the inaugural Indigidata Aotearoa 2023 was held at Te Whare Wānanga o Waikato. In recent years there has been significant advances in the fields of Indigenous data science and sovereignty. The Indigidata Aotearoa programme was designed to develop an understanding of Indigenous data science and sovereignty alongside some of the best researchers in Aotearoa New Zealand. The fully funded wānanga was open to Māori (tauira, kaitiaki, kaipakihi) participants from across Aotearoa. Applications were received from more than 35 respondents, and 23 tauira Māori attended the inaugural event.

text: Indigidata Aotearoa post-event summary report 2023 From the 21st to the 24th of August, the inaugural Indigidata Aotearoa 2023 was held at Te Whare Wānanga o Waikato. In recent years there has been significant advances in the fields of Indigenous data science and sovereignty. The Indigidata Aotearoa programme was designed to develop an understanding of Indigenous data science and sovereignty alongside some of the best researchers in Aotearoa New Zealand. The fully funded wānanga was open to Māori (tauira, kaitiaki, kaipakihi) participants from across Aotearoa. Applications were received from more than 35 respondents, and 23 tauira Māori attended the inaugural event.

year: 2023