title: Direct determination of vibrational density of states change on ligand binding to a protein

authors: Balog, Erika

subjects: protein

abstract: The change in the vibrational density of states of a protein (dihydrofolate reductase) on binding a ligand (methotrexate) is determined using inelastic neutron scattering. The vibrations of the complex soften significantly relative to the unbound protein. The resulting free-energy change, which is directly determined by the density of states change, is found to contribute significantly to the binding equilibrium.

text: Direct determination of vibrational density of states change on ligand binding to a protein The change in the vibrational density of states of a protein (dihydrofolate reductase) on binding a ligand (methotrexate) is determined using inelastic neutron scattering. The vibrations of the complex soften significantly relative to the unbound protein. The resulting free-energy change, which is directly determined by the density of states change, is found to contribute significantly to the binding equilibrium.

year: 2004

title: Video quality assessment considering the features of the Human Visual System

authors: Mozhaeva, Anastasia

abstract: Nowadays, numerous video compression quality assessment metrics are available. Some of these metrics are “objective” and only tangentially represent how a human observer rates video quality. On the other hand, models of the human visual system have been shown to be effective at describing spatial coding. In this work we propose a new quality metric which extends the peak signal to noise ratio metric with features of the human visual system measured using modern LCD screens. We also analyse the current visibility models of the early visual system and compare the commonly used quality metrics with metrics containing data modelling human perception. We examine the Pearson’s linear correlation coefficient of the various video compression quality metrics with human subjective scores on videos from the publicly available Netflix data set. Of the metrics tested, our new proposed metric is found to have the most stable high performance in predicting subjective video compression quality.

text: Video quality assessment considering the features of the Human Visual System Nowadays, numerous video compression quality assessment metrics are available. Some of these metrics are “objective” and only tangentially represent how a human observer rates video quality. On the other hand, models of the human visual system have been shown to be effective at describing spatial coding. In this work we propose a new quality metric which extends the peak signal to noise ratio metric with features of the human visual system measured using modern LCD screens. We also analyse the current visibility models of the early visual system and compare the commonly used quality metrics with metrics containing data modelling human perception. We examine the Pearson’s linear correlation coefficient of the various video compression quality metrics with human subjective scores on videos from the publicly available Netflix data set. Of the metrics tested, our new proposed metric is found to have the most stable high performance in predicting subjective video compression quality.

year: 2023

title: An indigenous voice at WIPO

authors: Toki, Valmaine

abstract: The demands for the recognition of rights for Indigenous peoples over time has led to the emergence of a common body of opinion based on long standing principles of international human rights law and policy. The existence of these rights for Indigenous people is unequivocal. The road to recognition has been arduous. The United Nations Declaration on the Rights of Indigenous Peoples [the Declaration] is the only international instrument that views Indigenous rights through an indigenous lens, crystallising many of the fundamental human rights of Indigenous peoples. The Declaration provides a framework and benchmark for the United Nations Permanent Forum on Indigenous Issues [the Permanent Forum].
This note reviews the background to the Declaration, and examines the role of the Permanent Forum, highlighting the connection between the two with a case study on intellectual property rights. It also offers comments about the future of Indigenous rights and the role of the Permanent Forum in promoting them.

text: An indigenous voice at WIPO The demands for the recognition of rights for Indigenous peoples over time has led to the emergence of a common body of opinion based on long standing principles of international human rights law and policy. The existence of these rights for Indigenous people is unequivocal. The road to recognition has been arduous. The United Nations Declaration on the Rights of Indigenous Peoples [the Declaration] is the only international instrument that views Indigenous rights through an indigenous lens, crystallising many of the fundamental human rights of Indigenous peoples. The Declaration provides a framework and benchmark for the United Nations Permanent Forum on Indigenous Issues [the Permanent Forum].
This note reviews the background to the Declaration, and examines the role of the Permanent Forum, highlighting the connection between the two with a case study on intellectual property rights. It also offers comments about the future of Indigenous rights and the role of the Permanent Forum in promoting them.

year: 2013