title: Beyond allotypes: The influence of allelic diversity in antibody constant domains

authors: Warrender, Annmaree Keely

abstract: Polymorphic diversity in antibody constant domains has long been defined by allotypic motifs that cross react with the sera of other individuals. Improvements in sequencing technologies have led to the discovery of a large number of new allelic sequences that underlie this diversity. Many of the point mutations lie outside traditional allotypic motifs suggesting they do not elicit immunogenic responses. As antibodies play an important role in immune defense and biotechnology, understanding how this newly resolved diversity influences the function of antibodies is important. This review investigates the current known diversity of antibody alleles at a protein level for each antibody isotype as well as the kappa and lambda light chains. We focus on evidence emerging for how these mutations perturb antibody interactions with antigens and Fc receptors that are critical for function, as well as the influence this might have on the use of antibodies as therapeutics and reagents.

text: Beyond allotypes: The influence of allelic diversity in antibody constant domains Polymorphic diversity in antibody constant domains has long been defined by allotypic motifs that cross react with the sera of other individuals. Improvements in sequencing technologies have led to the discovery of a large number of new allelic sequences that underlie this diversity. Many of the point mutations lie outside traditional allotypic motifs suggesting they do not elicit immunogenic responses. As antibodies play an important role in immune defense and biotechnology, understanding how this newly resolved diversity influences the function of antibodies is important. This review investigates the current known diversity of antibody alleles at a protein level for each antibody isotype as well as the kappa and lambda light chains. We focus on evidence emerging for how these mutations perturb antibody interactions with antigens and Fc receptors that are critical for function, as well as the influence this might have on the use of antibodies as therapeutics and reagents.

year: 2020

title: "We're like the sex CPR dummies": Negotiating (hetero)sex in a university residential setting

authors: Brown, Juliana

subjects: sex(uality)

abstract: Moving from high school and the family home to living in a communal university residence can be a significant transition, especially in regard to sexual activity and knowledge. The influence of variable sexuality education programmes, family context, and personal experiences, means that young students come to university with a wide range of sexual knowledge and experiences. The purpose of this
thesis is to represent the current narratives about sexuality and heterosex that are both prevalent and important for university students living in the residential community setting.
This research utilised a qualitative approach, with participants who were living in a University of Waikato Halls of Residence taking part in a men-only, or a women-only, focus group. Semi-structured group interviews were also conducted with key informants who work and live in residential halls. Multiple themes were explicated from the focus groups and group interviews, with some discourses overlapping groups (e.g. all groups discussed contraception) and some discourses being distinct to particular groups (e.g. women talked about sexual coercion).
One key finding was the dominant narratives that impact young women’s sexual pleasure. Following on from this were the ramifications of the sexual double standard for young women when living in a community setting. An additional key point of attention was the prominence of problematic sexual narratives when transitioning to the ‘adulthood’ of living in university halls. While participants were primarily happy with residential halls, information was shared regarding
how residential staff can impact on student living and contentment. Above all, it seemed that the year in residential halls appeared to be a year of liminality, or transition between ‘youth’ and ‘adult’. The findings from this research suggest a need for further investigation into sexuality discourses that profoundly impact young women and men, as well as the novel experiences of residential living.

text: "We're like the sex CPR dummies": Negotiating (hetero)sex in a university residential setting Moving from high school and the family home to living in a communal university residence can be a significant transition, especially in regard to sexual activity and knowledge. The influence of variable sexuality education programmes, family context, and personal experiences, means that young students come to university with a wide range of sexual knowledge and experiences. The purpose of this
thesis is to represent the current narratives about sexuality and heterosex that are both prevalent and important for university students living in the residential community setting.
This research utilised a qualitative approach, with participants who were living in a University of Waikato Halls of Residence taking part in a men-only, or a women-only, focus group. Semi-structured group interviews were also conducted with key informants who work and live in residential halls. Multiple themes were explicated from the focus groups and group interviews, with some discourses overlapping groups (e.g. all groups discussed contraception) and some discourses being distinct to particular groups (e.g. women talked about sexual coercion).
One key finding was the dominant narratives that impact young women’s sexual pleasure. Following on from this were the ramifications of the sexual double standard for young women when living in a community setting. An additional key point of attention was the prominence of problematic sexual narratives when transitioning to the ‘adulthood’ of living in university halls. While participants were primarily happy with residential halls, information was shared regarding
how residential staff can impact on student living and contentment. Above all, it seemed that the year in residential halls appeared to be a year of liminality, or transition between ‘youth’ and ‘adult’. The findings from this research suggest a need for further investigation into sexuality discourses that profoundly impact young women and men, as well as the novel experiences of residential living.

year: 2016

title: The "false generosity" of treaty settlements: innovation and contortion

authors: Te Aho, Linda

abstract: In Aotearoa New Zealand the ways in which indigenous claims to lands and waters are addressed are often looked to as good, or even best, practice by indigenous peoples around the world. While things are far from perfect, in recent decades Maori have succeeded in changing perceptions about the Treaty of Waitangi as the foundation of the nation, and work steadily continues on settling outstanding Treaty claims. The resulting Treaty of Waitangi settlements are negotiated arrangements which aim to remove a sense of historical grievance and achieve significant rebuilding of the Maori economy. They are seen by some as dynamic and powerful steps towards economic independence, as a means of recognising special relationships to lands and waters, and a necessary prerequisite to improved relationships between the state and the indigenous Maori in the future. ¹ Critics see the settlements and the processes followed to reach them as too heavily weighted in the government's favour. ² They argue that the settlements do not sufficiently compensate for actual losses. They are said to pit Maori against Maori. Diverse claimant groups are effectively forced to negotiate within standardised and fixed parameters. For these and other reasons, the settlement agreements, policies and processes have been labelled as divisive and compromising self-determination. ³

text: The "false generosity" of treaty settlements: innovation and contortion In Aotearoa New Zealand the ways in which indigenous claims to lands and waters are addressed are often looked to as good, or even best, practice by indigenous peoples around the world. While things are far from perfect, in recent decades Maori have succeeded in changing perceptions about the Treaty of Waitangi as the foundation of the nation, and work steadily continues on settling outstanding Treaty claims. The resulting Treaty of Waitangi settlements are negotiated arrangements which aim to remove a sense of historical grievance and achieve significant rebuilding of the Maori economy. They are seen by some as dynamic and powerful steps towards economic independence, as a means of recognising special relationships to lands and waters, and a necessary prerequisite to improved relationships between the state and the indigenous Maori in the future. ¹ Critics see the settlements and the processes followed to reach them as too heavily weighted in the government's favour. ² They argue that the settlements do not sufficiently compensate for actual losses. They are said to pit Maori against Maori. Diverse claimant groups are effectively forced to negotiate within standardised and fixed parameters. For these and other reasons, the settlement agreements, policies and processes have been labelled as divisive and compromising self-determination. ³

year: 2017