title: Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans

authors: Olszewski, Pawel K.

subjects: ioenergetics

abstract: Neurobeachin (Nbea) regulates neuronal membrane protein trafficking and is required for the development and functioning of central and neuromuscular synapses. In homozygous knockout (KO) mice, Nbea deficiency causes perinatal death. Here, we report that heterozygous KO mice haploinsufficient for Nbea have higher body weight due to increased adipose tissue mass. In several feeding paradigms, heterozygous KO mice consumed more food than wild-type (WT) controls, and this consumption was primarily driven by calories rather than palatability. Expression analysis of feeding-related genes in the hypothalamus and brainstem with real-time PCR showed differential expression of a subset of neuropeptide or neuropeptide receptor mRNAs between WT and Nbea+/− mice in the sated state and in response to food deprivation, but not to feeding reward. In humans, we identified two intronic NBEA single-nucleotide polymorphisms (SNPs) that are significantly associated with body-mass index (BMI) in adult and juvenile cohorts. Overall, data obtained in mice and humans suggest that variation of Nbea abundance or activity critically affects body weight, presumably by influencing the activity of feeding-related neural circuits. Our study emphasizes the importance of neural mechanisms in body weight control and points out NBEA as a potential risk gene in human obesity.

text: Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans Neurobeachin (Nbea) regulates neuronal membrane protein trafficking and is required for the development and functioning of central and neuromuscular synapses. In homozygous knockout (KO) mice, Nbea deficiency causes perinatal death. Here, we report that heterozygous KO mice haploinsufficient for Nbea have higher body weight due to increased adipose tissue mass. In several feeding paradigms, heterozygous KO mice consumed more food than wild-type (WT) controls, and this consumption was primarily driven by calories rather than palatability. Expression analysis of feeding-related genes in the hypothalamus and brainstem with real-time PCR showed differential expression of a subset of neuropeptide or neuropeptide receptor mRNAs between WT and Nbea+/− mice in the sated state and in response to food deprivation, but not to feeding reward. In humans, we identified two intronic NBEA single-nucleotide polymorphisms (SNPs) that are significantly associated with body-mass index (BMI) in adult and juvenile cohorts. Overall, data obtained in mice and humans suggest that variation of Nbea abundance or activity critically affects body weight, presumably by influencing the activity of feeding-related neural circuits. Our study emphasizes the importance of neural mechanisms in body weight control and points out NBEA as a potential risk gene in human obesity.

year: 2012

title: Effect of contextual information on object tracking

authors: Hedayati, Mohammad

subjects: video analysis

abstract: Local object information, such as the appearance and motion features of the object, are useful for object tracking in videos provided the object is not occluded by other elements in the scene. During occlusion, however, the local object information in the video frame does not properly represent the true properties of the object, which leads to tracking failure. We propose a framework that combines multiple cues including the local object information, the background characteristics and group motion dynamics to improve object tracking in challenging cluttered environments. The performance of the proposed tracking model is compared with the kernelised correlation filter (KCF) tracker. In the tested video sequences the proposed tracking model correctly tracked objects even when the KCF tracker failed because of occlusion and background noise.

text: Effect of contextual information on object tracking Local object information, such as the appearance and motion features of the object, are useful for object tracking in videos provided the object is not occluded by other elements in the scene. During occlusion, however, the local object information in the video frame does not properly represent the true properties of the object, which leads to tracking failure. We propose a framework that combines multiple cues including the local object information, the background characteristics and group motion dynamics to improve object tracking in challenging cluttered environments. The performance of the proposed tracking model is compared with the kernelised correlation filter (KCF) tracker. In the tested video sequences the proposed tracking model correctly tracked objects even when the KCF tracker failed because of occlusion and background noise.

year: 2017

title: Introduction to tephra-derived soils, North Island, New Zealand: University of Waikato and University of Wisconsin-Platteville post-conference Andisol excursion, 21-23 December, 2016

authors: Lowe, David J.

abstract: Provisional itinerary DAY 1 Wednesday 21 December: Mamaku Plateau-Rerewhakaaitu-Lake Tarawera: 1 Goodwin Farm, Tapapa Rd, Tapapa: welded ignimbrite, tephras, loess, buried soils (Tirau soil) - stratigraphy of sequence (230 ka and younger) and upbuilding pedogenesis - Tirau silt loam 2 Brett Rd, Rerewhakaaitu: Holocene tephras and buried soil (Rotomahana soil) - Volcanic landscape, historical importance of area for NZ soil survey - Stratigraphy of sequence (~9.5 cal ka to 10 June 1886 Tarawera eruption) and upbuilding pedogenesis - Rotomahana sandy loam, 3 Ash Pit Rd, Rerewhakaaitu: tephras and buried soils (Matahina soil) - Matahina gravel - buried spodic/podzol soil features, 4 Okareka Loop Rd tephra section with proximal Rotorua Tephra and buried soils, loess, Buried Village Museum, Te Wairoa, Lake Tarawera (Stoney Point). DAY 2 Thursday 22 December: Otorohanga-Waitomo Caves -Pirongia Mountain: 1 Raynes Road section: Ultisol in composite tephra sequence (Kainui soil), 2 Otorohanga Kiwi House, 3 Waitomo Caves,, 4 Pirongia Mountain: Mangakara forest walk, 5 Evening meal on an Andisol. DAY 3 Friday 23 December: Hobbiton, Hamilton gardens including Te Parapara (ancient Maori garden): 1. Hobbiton tour 10.15 am (2 hrs), 2. Hamilton Gardens incl. Te Parapara Garden and human-modified soils (Tamahere soil).

text: Introduction to tephra-derived soils, North Island, New Zealand: University of Waikato and University of Wisconsin-Platteville post-conference Andisol excursion, 21-23 December, 2016 Provisional itinerary DAY 1 Wednesday 21 December: Mamaku Plateau-Rerewhakaaitu-Lake Tarawera: 1 Goodwin Farm, Tapapa Rd, Tapapa: welded ignimbrite, tephras, loess, buried soils (Tirau soil) - stratigraphy of sequence (230 ka and younger) and upbuilding pedogenesis - Tirau silt loam 2 Brett Rd, Rerewhakaaitu: Holocene tephras and buried soil (Rotomahana soil) - Volcanic landscape, historical importance of area for NZ soil survey - Stratigraphy of sequence (~9.5 cal ka to 10 June 1886 Tarawera eruption) and upbuilding pedogenesis - Rotomahana sandy loam, 3 Ash Pit Rd, Rerewhakaaitu: tephras and buried soils (Matahina soil) - Matahina gravel - buried spodic/podzol soil features, 4 Okareka Loop Rd tephra section with proximal Rotorua Tephra and buried soils, loess, Buried Village Museum, Te Wairoa, Lake Tarawera (Stoney Point). DAY 2 Thursday 22 December: Otorohanga-Waitomo Caves -Pirongia Mountain: 1 Raynes Road section: Ultisol in composite tephra sequence (Kainui soil), 2 Otorohanga Kiwi House, 3 Waitomo Caves,, 4 Pirongia Mountain: Mangakara forest walk, 5 Evening meal on an Andisol. DAY 3 Friday 23 December: Hobbiton, Hamilton gardens including Te Parapara (ancient Maori garden): 1. Hobbiton tour 10.15 am (2 hrs), 2. Hamilton Gardens incl. Te Parapara Garden and human-modified soils (Tamahere soil).

year: 2016-12-21