title: Metaheuristic optimization of insulin infusion protocols using historical data with validation using a patient simulator

authors: Wang, Hongyu

subjects: computer science

abstract: Metaheuristic search algorithms are used to develop new protocols for optimal intravenous insulin infusion rate recommendations in scenarios involving hospital in-patients with Type 1 Diabetes. Two metaheuristic search algorithms are used, namely, Particle Swarm Optimization and Covariance Matrix Adaption Evolution Strategy. The Glucose Regulation for Intensive Care Patients (GRIP) serves as the starting point of the optimization process. We base our experiments on a methodology in the literature to evaluate the favorability of insulin protocols, with a dataset of blood glucose level/insulin infusion rate time series records from 16 patients obtained from the Waikato District Health Board. New and significantly better insulin infusion strategies than GRIP are discovered from the data through metaheuristic search. The newly discovered strategies are further validated and show good performance against various competitive benchmarks using a virtual patient simulator.

text: Metaheuristic optimization of insulin infusion protocols using historical data with validation using a patient simulator Metaheuristic search algorithms are used to develop new protocols for optimal intravenous insulin infusion rate recommendations in scenarios involving hospital in-patients with Type 1 Diabetes. Two metaheuristic search algorithms are used, namely, Particle Swarm Optimization and Covariance Matrix Adaption Evolution Strategy. The Glucose Regulation for Intensive Care Patients (GRIP) serves as the starting point of the optimization process. We base our experiments on a methodology in the literature to evaluate the favorability of insulin protocols, with a dataset of blood glucose level/insulin infusion rate time series records from 16 patients obtained from the Waikato District Health Board. New and significantly better insulin infusion strategies than GRIP are discovered from the data through metaheuristic search. The newly discovered strategies are further validated and show good performance against various competitive benchmarks using a virtual patient simulator.

year: 2021

title: Imperial landscapes of health: Place, plants and people between India and Australia, 1800s-1900s.

authors: Beattie, James John

subjects: Imperial health

abstract: In the nineteenth century, place bore immediately and urgently on questions of imperialism, race, and health. This article considers European strategies to control local environments and improve healthiness through the exchange of people, plants, ideas and garden designs between India and Australia. Migration removed Europeans from unhealthy environments, either permanently (to Australia and elsewhere) or temporarily (to hill stations in India). Trees like the eucalyptus were introduced into India to enhance European health, based on belief they drained sources of disease. I argue a crucial new understanding of the intersection between health and place in the nineteenth-century British Empire can be provided by tracing the networks through which people, plants, and ideas moved to consider the broader imperial frameworks.

text: Imperial landscapes of health: Place, plants and people between India and Australia, 1800s-1900s. In the nineteenth century, place bore immediately and urgently on questions of imperialism, race, and health. This article considers European strategies to control local environments and improve healthiness through the exchange of people, plants, ideas and garden designs between India and Australia. Migration removed Europeans from unhealthy environments, either permanently (to Australia and elsewhere) or temporarily (to hill stations in India). Trees like the eucalyptus were introduced into India to enhance European health, based on belief they drained sources of disease. I argue a crucial new understanding of the intersection between health and place in the nineteenth-century British Empire can be provided by tracing the networks through which people, plants, and ideas moved to consider the broader imperial frameworks.

year: 2012

title: Indigenous fertility in Aotearoa New Zealand: How does ethnic identity affect birth spacing and timing?

authors: Rarere, Moana

abstract: The survival of Indigenous peoples in the CANZUS states of Canada, Australia, Aotearoa New Zealand, and the United States is nothing short of remarkable. Not only have Indigenous peoples thwarted colonial tropes of the vanishing native but, for decades, Indigenous population growth rates have significantly outpaced those of the dominant settler populations. The future survival of Indigenous peoples fundamentally rests on continued natural increase, and understanding the causes and consequences of fertility behaviour is critical. While total fertility rates for Indigenous women in CANZUS countries are relatively low, childbearing tends to be concentrated at younger ages in contrast to the dominant white populations. The fertility transitions of both settler and Indigenous populations in the CANZUS states are well documented, however, a significant gap remains: how cultural factors shape contemporary Indigenous fertility behaviours. Using Aotearoa as a case study, we explore the relationship between Māori cultural identity, birth timing, and the duration of birth intervals. We use the 1995 New Zealand Women: Family, Employment and Education survey data to further test the impact of cultural identity on birth transition rates using the piecewise exponential model and Kaplan-Meier estimates. We find that women who identify Mainly Māori (exclusively or primarily) are at greater risk of bearing much earlier to first birth but not necessarily subsequent births. However, because of the earlier start, Māori have a longer reproductive window to bear more children, and at higher birth orders still bear earlier than non-Māori. The empirical evidence strengthens our case to suggest that cultural orientation has some influence on Indigenous fertility and contributes to the development of Indigenous-centred theories of fertility and demography more broadly.

text: Indigenous fertility in Aotearoa New Zealand: How does ethnic identity affect birth spacing and timing? The survival of Indigenous peoples in the CANZUS states of Canada, Australia, Aotearoa New Zealand, and the United States is nothing short of remarkable. Not only have Indigenous peoples thwarted colonial tropes of the vanishing native but, for decades, Indigenous population growth rates have significantly outpaced those of the dominant settler populations. The future survival of Indigenous peoples fundamentally rests on continued natural increase, and understanding the causes and consequences of fertility behaviour is critical. While total fertility rates for Indigenous women in CANZUS countries are relatively low, childbearing tends to be concentrated at younger ages in contrast to the dominant white populations. The fertility transitions of both settler and Indigenous populations in the CANZUS states are well documented, however, a significant gap remains: how cultural factors shape contemporary Indigenous fertility behaviours. Using Aotearoa as a case study, we explore the relationship between Māori cultural identity, birth timing, and the duration of birth intervals. We use the 1995 New Zealand Women: Family, Employment and Education survey data to further test the impact of cultural identity on birth transition rates using the piecewise exponential model and Kaplan-Meier estimates. We find that women who identify Mainly Māori (exclusively or primarily) are at greater risk of bearing much earlier to first birth but not necessarily subsequent births. However, because of the earlier start, Māori have a longer reproductive window to bear more children, and at higher birth orders still bear earlier than non-Māori. The empirical evidence strengthens our case to suggest that cultural orientation has some influence on Indigenous fertility and contributes to the development of Indigenous-centred theories of fertility and demography more broadly.

year: 2023