title: Delivery of a coated bioactive from a rumen controlled-release device

authors: Syzov, Vladyslav

subjects: Eudragit E100

abstract: Ruminants possess a unique digestive system. Using the high metabolic potential of the symbiotic microflora of the rumen, ruminants are capable of digesting plant material and obtaining nutrients and energy from this process. Because of the ruminal fermentation, the most bioactives are not stable in the harsh ruminal environment. Therefore there is a need to improve the bioavailability of a bioactive by protecting it from the ruminal digestion. The formulation of protected bioactive can be delivered in the rumen in a controlled manner and over a long period of time.

In this project the degree of rumen protection was estimated using model substrates (sugar pellets and granules). These materials were coated with the pH-sensitive polymer Eudragit E. The model bioactive (phloridizin) was coated using the coating methodology adopted from exploratory studies with model substrates. The bioavailability of protected (coated) phloridizin was assessed by administering directly into the abomasum of fistulated cows.

Formulation of protected phloridizin was used to demonstrate the feasibility of bioactive controlled delivery based on ART ( Active Rumen Technology ). This technology uses an elevated gas pressure created by a hydrogen-producing cell to drive a plunger which extrudes bioactive formulation from an intraruminal controlled-release device.

Four groups of devices filled with formulation containing different amounts of protected phloridizin were tested. The bioactive was released in a controlled manner over several days. The formulation release profiles were reproducible suggesting that in principle the technology can be further developed to use in a commercial sense or for research purposes. The limitations of the technology, including formulation issues and gas diffusion through barrel walls, were identified.

text: Delivery of a coated bioactive from a rumen controlled-release device Ruminants possess a unique digestive system. Using the high metabolic potential of the symbiotic microflora of the rumen, ruminants are capable of digesting plant material and obtaining nutrients and energy from this process. Because of the ruminal fermentation, the most bioactives are not stable in the harsh ruminal environment. Therefore there is a need to improve the bioavailability of a bioactive by protecting it from the ruminal digestion. The formulation of protected bioactive can be delivered in the rumen in a controlled manner and over a long period of time.

In this project the degree of rumen protection was estimated using model substrates (sugar pellets and granules). These materials were coated with the pH-sensitive polymer Eudragit E. The model bioactive (phloridizin) was coated using the coating methodology adopted from exploratory studies with model substrates. The bioavailability of protected (coated) phloridizin was assessed by administering directly into the abomasum of fistulated cows.

Formulation of protected phloridizin was used to demonstrate the feasibility of bioactive controlled delivery based on ART ( Active Rumen Technology ). This technology uses an elevated gas pressure created by a hydrogen-producing cell to drive a plunger which extrudes bioactive formulation from an intraruminal controlled-release device.

Four groups of devices filled with formulation containing different amounts of protected phloridizin were tested. The bioactive was released in a controlled manner over several days. The formulation release profiles were reproducible suggesting that in principle the technology can be further developed to use in a commercial sense or for research purposes. The limitations of the technology, including formulation issues and gas diffusion through barrel walls, were identified.

year: 2008

title: Editorial

authors: Strachan, Jane

subjects: education

abstract: An introduction is presented in which the editor discusses various reports within the issue on topics including the sustainability of organisational changes for diploma programmes, the development of Preparation for Tertiary Learning (PTL), and childhood teacher education programme in New Zealand.

text: Editorial An introduction is presented in which the editor discusses various reports within the issue on topics including the sustainability of organisational changes for diploma programmes, the development of Preparation for Tertiary Learning (PTL), and childhood teacher education programme in New Zealand.

year: 2011

title: Indigenous Psychology in Aotearoa: Realising Māori Aspirations

authors: Levy, Michelle Patricia

subjects: Maori

abstract: Indigenous psychology in Aotearoa positions the aspirations of Māori as central.  The aim of this thesis is to describe and contribute to the development of a psychological discipline which is relevant and of benefit for Māori communities.  Part One sets the scene in Aotearoa, examining the relationship between Māori development and psychology.  Part Two explores the indigenous psychology literature base, identifying strategies which may be relevant to Aotearoa.  The key themes of context, critical mass, and mechanisms to support indigenous psychology development are identified as being relevant to Aotearoa.  Part Three explores indigenous psychology development in Aotearoa.  Data from a range of sources is qualitatively analysed to develop five themes which describe the current status of Māori development in psychology, the importance of the critical mass and the notion of collective responsibility.  Part Four, drawing from the analysis in Parts One, Two and Three, identifies 'reaching the point of irreversible change' as the next phase of indigenous psychology development in Aotearoa.  This is the point at which indigenous psychology development becomes self-sustaining.  

The point at which irreversible change occurs is when: Māori knowledge bases are a legitimate part of psychology in Aotearoa; resistance to the legitimacy of Māori knowledge bases in psychology is not a characteristic of our landscape; environments supportive of indigenous psychology development are commonplace; and responsibility for contributing to indigenous psychology development is shared among and sustained by the collective capacity of the Leaders and Producers.  Consolidation, the process by which multiple and interrelated pathways are connected to form a unified whole, is fundamental to reaching the point of irreversible change.  An original interactional framework for consolidation is proposed.  This framework is based on two key consolidating mechanisms: a working description of Kaupapa Māori Psychologies; and a Kaupapa Māori Psychologies Research and Training Centre.  Psychologies relevant and of benefit to Māori communities which contribute to the realisation of Māori aspirations are the cornerstones, with all elements of the framework leading back into this fundamental foundation.

text: Indigenous Psychology in Aotearoa: Realising Māori Aspirations Indigenous psychology in Aotearoa positions the aspirations of Māori as central.  The aim of this thesis is to describe and contribute to the development of a psychological discipline which is relevant and of benefit for Māori communities.  Part One sets the scene in Aotearoa, examining the relationship between Māori development and psychology.  Part Two explores the indigenous psychology literature base, identifying strategies which may be relevant to Aotearoa.  The key themes of context, critical mass, and mechanisms to support indigenous psychology development are identified as being relevant to Aotearoa.  Part Three explores indigenous psychology development in Aotearoa.  Data from a range of sources is qualitatively analysed to develop five themes which describe the current status of Māori development in psychology, the importance of the critical mass and the notion of collective responsibility.  Part Four, drawing from the analysis in Parts One, Two and Three, identifies 'reaching the point of irreversible change' as the next phase of indigenous psychology development in Aotearoa.  This is the point at which indigenous psychology development becomes self-sustaining.  

The point at which irreversible change occurs is when: Māori knowledge bases are a legitimate part of psychology in Aotearoa; resistance to the legitimacy of Māori knowledge bases in psychology is not a characteristic of our landscape; environments supportive of indigenous psychology development are commonplace; and responsibility for contributing to indigenous psychology development is shared among and sustained by the collective capacity of the Leaders and Producers.  Consolidation, the process by which multiple and interrelated pathways are connected to form a unified whole, is fundamental to reaching the point of irreversible change.  An original interactional framework for consolidation is proposed.  This framework is based on two key consolidating mechanisms: a working description of Kaupapa Māori Psychologies; and a Kaupapa Māori Psychologies Research and Training Centre.  Psychologies relevant and of benefit to Māori communities which contribute to the realisation of Māori aspirations are the cornerstones, with all elements of the framework leading back into this fundamental foundation.

year: 2007