title: Editorial

authors: Locke, Terry

subjects: curriculum

abstract: The scrutiny of any educational system inevitably raises issues about constructions of worthwhile knowledge (content) and how the learning of knowledge so-deemed should be managed (pedagogy). Issues of national curriculum reform are discussed by a number of writers in this issue. In providing an overview of the Australian situation, Wayne Sawyer raises issues related to the uneasy tension between increasingly critical English curriculum formulations and narrowly defined literacy testing regimes. Writing of the situation in England, Richard Andrews details ways in which curricular reform still operates within a conservative, target-setting and assessment driven model. Terry Locke makes similar points about the New Zealand situation, when he discusses ways in which assessment reforms, especially when related to high-stakes qualifications reforms, construct their own de facto curriculums. The article on the South African situation, by Hilary Janks and Jeanne Prinsloo, is a reminder of ways in which issues of power (and disempowerment) are implicated in curricular constructions.

text: Editorial The scrutiny of any educational system inevitably raises issues about constructions of worthwhile knowledge (content) and how the learning of knowledge so-deemed should be managed (pedagogy). Issues of national curriculum reform are discussed by a number of writers in this issue. In providing an overview of the Australian situation, Wayne Sawyer raises issues related to the uneasy tension between increasingly critical English curriculum formulations and narrowly defined literacy testing regimes. Writing of the situation in England, Richard Andrews details ways in which curricular reform still operates within a conservative, target-setting and assessment driven model. Terry Locke makes similar points about the New Zealand situation, when he discusses ways in which assessment reforms, especially when related to high-stakes qualifications reforms, construct their own de facto curriculums. The article on the South African situation, by Hilary Janks and Jeanne Prinsloo, is a reminder of ways in which issues of power (and disempowerment) are implicated in curricular constructions.

year: 2002

title: The Effect of a Myostatin Antagonist on the Healing of Burn Wounds in Skin.

authors: Fieten, Daniel John

subjects: skin

abstract: The body's remarkable ability to repair itself from damage is both very useful and extremely complex. The wound healing system is characterised by four overlapping phases: hemostasis, inflammation, proliferation, and remodelling. It is designed to heal rapidly and efficiently any breach in the protective barrier we call skin, in order to restore normal body function in the quickest possible time. However, pathological conditions such as keloids or hypertrophic scar may arise if events in the wound healing cascade are not coordinated properly, which can lead to loss of skin function and disfigurement. The purpose of this study was to determine whether myostatin plays a role in the healing of burn wounds in skin. Myostatin is best known for its powerful negative regulation of muscle development. Absence of myostatin results in a heavy muscling phenotype, whereas over-expression is associated with muscle wasting conditions. Recently, myostatin has been shown to be involved in muscle wound healing, where knockout of the myostatin gene resulted in improved healing, with decreased fibrotic scar tissue formation. It is noteworthy that the cell surface receptor to which myostatin binds is also present in skin. In consideration of this information the prospect of myostatin involvement in skin biology represents a gap in scientific knowledge. Therefore, the present investigation was designed to ascertain whether the effects of myostatin in muscle regeneration can also be seen in skin wound healing. To this end, a mouse burn wound model was designed to determine the efficacy of antagonising myostatin to bring about improved healing and decreased fibrosis of skin burns. Wounds of mice treated with the myostatin antagonist showed no significant difference compared to saline-treated controls in collagen content at any time point. Gene expression studies on TGF-β1, TGF-β3, decorin and fibromodulin revealed that differences between antagonist-treated and saline-treated groups were possibly masked by the effect of the burn injury but were present in uninjured skin. Similarly, uninjured skin of antagonist-treated animals exhibited a significantly higher fluid content than uninjured skin of saline-treated animals, whereas the effect was not significant in burned skin between treatments. Histological analysis revealed that antagonist-treated wounds showed evidence of decreased wound contraction which may indicate improved scar resolution and decreased risk of fibrosis. Interestingly, the gene expression results in many ways parallel those seen in foetal skin, which after injury, heals without scar. These results warrant further study into the subject area, especially to observe whether further improvements can be made by adjusting the treatment regimen.

text: The Effect of a Myostatin Antagonist on the Healing of Burn Wounds in Skin. The body's remarkable ability to repair itself from damage is both very useful and extremely complex. The wound healing system is characterised by four overlapping phases: hemostasis, inflammation, proliferation, and remodelling. It is designed to heal rapidly and efficiently any breach in the protective barrier we call skin, in order to restore normal body function in the quickest possible time. However, pathological conditions such as keloids or hypertrophic scar may arise if events in the wound healing cascade are not coordinated properly, which can lead to loss of skin function and disfigurement. The purpose of this study was to determine whether myostatin plays a role in the healing of burn wounds in skin. Myostatin is best known for its powerful negative regulation of muscle development. Absence of myostatin results in a heavy muscling phenotype, whereas over-expression is associated with muscle wasting conditions. Recently, myostatin has been shown to be involved in muscle wound healing, where knockout of the myostatin gene resulted in improved healing, with decreased fibrotic scar tissue formation. It is noteworthy that the cell surface receptor to which myostatin binds is also present in skin. In consideration of this information the prospect of myostatin involvement in skin biology represents a gap in scientific knowledge. Therefore, the present investigation was designed to ascertain whether the effects of myostatin in muscle regeneration can also be seen in skin wound healing. To this end, a mouse burn wound model was designed to determine the efficacy of antagonising myostatin to bring about improved healing and decreased fibrosis of skin burns. Wounds of mice treated with the myostatin antagonist showed no significant difference compared to saline-treated controls in collagen content at any time point. Gene expression studies on TGF-β1, TGF-β3, decorin and fibromodulin revealed that differences between antagonist-treated and saline-treated groups were possibly masked by the effect of the burn injury but were present in uninjured skin. Similarly, uninjured skin of antagonist-treated animals exhibited a significantly higher fluid content than uninjured skin of saline-treated animals, whereas the effect was not significant in burned skin between treatments. Histological analysis revealed that antagonist-treated wounds showed evidence of decreased wound contraction which may indicate improved scar resolution and decreased risk of fibrosis. Interestingly, the gene expression results in many ways parallel those seen in foetal skin, which after injury, heals without scar. These results warrant further study into the subject area, especially to observe whether further improvements can be made by adjusting the treatment regimen.

year: 2009

title: Te Kuranui

authors: Maxwell, Te Kahautu

abstract: Ko te tūāpapa o tēnei kōrero Te Kuranui he titiro ki te tūāpapa o Ōpōtiki Mai Tawhiti kapa haka. He aha te take i whakatūngia ai tēnei Kuranui e karangatia ana ko Ōpōtiki Mai Tawhiti? Hai tāhūhū mō tēnei tuhinga raurūtia tēnei kupu whakaari a Te Kōoti Arikirangi; “He Kura hoki ahau”, me tēnei wehenga o te mōteatea nāna; Te Pono ki runga rā, te ara mai o te tika. Tukua mai ki raro nā te maungarongo; te whana i tū ai nā te kotahitanga; te aroha i mau ai. Ana ko te Kupu Whakaari nei; He Kura hoki ahau he wewete i tēnei Kupu Whakaari kia kite i te hōhonu o te tikanga ōna hai whakatamārama i tō Te Kōoti wawata hai kura i tana iwi Ringatū me tā te kaituhi whakaraupapa i ēnei kura ki roto i te whakairotanga i te Kuranui nei.
Ka rua kua tātaritia tēnei wehenga o te mōteatea nei kia rima ōna wāhanga hai taki i tēnei tuhinga epā ana ki te Kuranui nei a Ōpōtiki Mai Tawhiti. Tuatahi Te Pono ki runga rā, ka titiro ki te kaituhi nei me tōna whakatipuranga i ōna kaumātua me ō rātou kuranga i a ia kia tohenihorau ki tōna ao Māori. He kuranga ēnei hai maungāngākau, maungāhinengaro ki te whakaturuki i te Kuranui a Ōpōtiki Mai Tawhiti. Te ara mai o te tika, ko te whakatūtanga o te kapa haka nei a Ōpōtiki Mai Tawhiti te Kuranui,arā te whakapaparanga mai i te kapa i tōna tīmatatanga ki te wā tonu nei. Tukua mai ki raro nā te maungarongo; ko te whakapono tēnei wāhanga, ko te ū o Ōpōtiki Mai Tawhiti ki tēnei kura a Te Kooti Arikirangi. Te whana i tū ai nā te kotahitanga;ko te titiro ki te pouārahi me te whakapau kaha ki te tuitui i ngā whakaaro o te katoa, ko te ranga i te iwi, ko te pupuri i te iwi, i te kapa haka ki tōna, rautaki, whāinga ko te whakakotahitanga i te iwi i raro i te kaupapa o Ōpōtiki Mai Tawhiti. Te aroha i mau ai, ko te aroha ki te iwi, ko te aroha ki te kaupapa, ko te whakaū, whakapūmau i te moemoeā kia whakahokia mai te toheariki ki te iwi kia tū toherauariki a Te Whakatōhea i raro i te korowai o Ōpōtiki Mai Tawhiti.

text: Te Kuranui Ko te tūāpapa o tēnei kōrero Te Kuranui he titiro ki te tūāpapa o Ōpōtiki Mai Tawhiti kapa haka. He aha te take i whakatūngia ai tēnei Kuranui e karangatia ana ko Ōpōtiki Mai Tawhiti? Hai tāhūhū mō tēnei tuhinga raurūtia tēnei kupu whakaari a Te Kōoti Arikirangi; “He Kura hoki ahau”, me tēnei wehenga o te mōteatea nāna; Te Pono ki runga rā, te ara mai o te tika. Tukua mai ki raro nā te maungarongo; te whana i tū ai nā te kotahitanga; te aroha i mau ai. Ana ko te Kupu Whakaari nei; He Kura hoki ahau he wewete i tēnei Kupu Whakaari kia kite i te hōhonu o te tikanga ōna hai whakatamārama i tō Te Kōoti wawata hai kura i tana iwi Ringatū me tā te kaituhi whakaraupapa i ēnei kura ki roto i te whakairotanga i te Kuranui nei.
Ka rua kua tātaritia tēnei wehenga o te mōteatea nei kia rima ōna wāhanga hai taki i tēnei tuhinga epā ana ki te Kuranui nei a Ōpōtiki Mai Tawhiti. Tuatahi Te Pono ki runga rā, ka titiro ki te kaituhi nei me tōna whakatipuranga i ōna kaumātua me ō rātou kuranga i a ia kia tohenihorau ki tōna ao Māori. He kuranga ēnei hai maungāngākau, maungāhinengaro ki te whakaturuki i te Kuranui a Ōpōtiki Mai Tawhiti. Te ara mai o te tika, ko te whakatūtanga o te kapa haka nei a Ōpōtiki Mai Tawhiti te Kuranui,arā te whakapaparanga mai i te kapa i tōna tīmatatanga ki te wā tonu nei. Tukua mai ki raro nā te maungarongo; ko te whakapono tēnei wāhanga, ko te ū o Ōpōtiki Mai Tawhiti ki tēnei kura a Te Kooti Arikirangi. Te whana i tū ai nā te kotahitanga;ko te titiro ki te pouārahi me te whakapau kaha ki te tuitui i ngā whakaaro o te katoa, ko te ranga i te iwi, ko te pupuri i te iwi, i te kapa haka ki tōna, rautaki, whāinga ko te whakakotahitanga i te iwi i raro i te kaupapa o Ōpōtiki Mai Tawhiti. Te aroha i mau ai, ko te aroha ki te iwi, ko te aroha ki te kaupapa, ko te whakaū, whakapūmau i te moemoeā kia whakahokia mai te toheariki ki te iwi kia tū toherauariki a Te Whakatōhea i raro i te korowai o Ōpōtiki Mai Tawhiti.

year: 2014-09-27