title: Designing, measuring and modelling a small-scale coil and stimulation circuit for transcranial magnetic stimulation

authors: Khokhar, Farah Adeebah

abstract: In Transcranial Magnetic Stimulation (TMS) rapid electromagnetic (EM) fields are applied to the brain, via an external current-carrying coil. This technique has been tried for many neurological disorders such as stroke, Parkinson’s disease and major depression. The fundamental effects of TMS are poorly understood so there is a need to carry out invasive measurements on mice to gain deep understanding about the underlying principles of TMS. However, we require smaller coils than used for a human, equivalent to the size of the mouse brain. Based on established physics principles we designed and built a cylindrical coil consisting of 50 turns of 0.2 mm diameter copper wire around a 4 mm diameter soft ferrite core. We built a simple electronic circuit to discharge a capacitor through this coil. With an applied voltage of 45 V, we measured the magnetic flux density (B-field) with a Hall probe as 338 mT and induced electric field with a wire loop as 10 – 15 V/m. The temperature increased by 31°C after 1200 pulses at 5 Hz. We modelled the coil using MATLAB which gave similar B-field and E field results of around 500 mT and 8 V/m respectively. Although this coil performs better than previously constructed mouse coils, the EM fields are still considerably lower than those of typical human coil of 2 T and 250 V/m. This now allows us to stimulate mouse brains with higher B-fields and E-fields than in previous experiments.

text: Designing, measuring and modelling a small-scale coil and stimulation circuit for transcranial magnetic stimulation In Transcranial Magnetic Stimulation (TMS) rapid electromagnetic (EM) fields are applied to the brain, via an external current-carrying coil. This technique has been tried for many neurological disorders such as stroke, Parkinson’s disease and major depression. The fundamental effects of TMS are poorly understood so there is a need to carry out invasive measurements on mice to gain deep understanding about the underlying principles of TMS. However, we require smaller coils than used for a human, equivalent to the size of the mouse brain. Based on established physics principles we designed and built a cylindrical coil consisting of 50 turns of 0.2 mm diameter copper wire around a 4 mm diameter soft ferrite core. We built a simple electronic circuit to discharge a capacitor through this coil. With an applied voltage of 45 V, we measured the magnetic flux density (B-field) with a Hall probe as 338 mT and induced electric field with a wire loop as 10 – 15 V/m. The temperature increased by 31°C after 1200 pulses at 5 Hz. We modelled the coil using MATLAB which gave similar B-field and E field results of around 500 mT and 8 V/m respectively. Although this coil performs better than previously constructed mouse coils, the EM fields are still considerably lower than those of typical human coil of 2 T and 250 V/m. This now allows us to stimulate mouse brains with higher B-fields and E-fields than in previous experiments.

year: 2018

title: The WEKA data mining software: An update

authors: Hall, Mark A.

subjects: computer science

abstract: More than twelve years have elapsed since the first public release of WEKA. In that time, the software has been rewritten entirely from scratch, evolved substantially and now accompanies a text on data mining. These days, WEKA enjoys widespread acceptance in both academia and business, has an active community, and has been downloaded more than 1.4 million times since being placed on Source-Forge in April 2000. This paper provides an introduction to the WEKA workbench, reviews the history of the project, and, in light of the recent 3.6 stable release, briefly discusses what has been added since the last stable version (Weka 3.4) released in 2003.

text: The WEKA data mining software: An update More than twelve years have elapsed since the first public release of WEKA. In that time, the software has been rewritten entirely from scratch, evolved substantially and now accompanies a text on data mining. These days, WEKA enjoys widespread acceptance in both academia and business, has an active community, and has been downloaded more than 1.4 million times since being placed on Source-Forge in April 2000. This paper provides an introduction to the WEKA workbench, reviews the history of the project, and, in light of the recent 3.6 stable release, briefly discusses what has been added since the last stable version (Weka 3.4) released in 2003.

year: 2009

title: The Treaty, tikanga Māori, ecosystem-based management, mainstream law and power sharing for environmental integrity in Aotearoa New Zealand – possible ways forward

authors: Joseph, Robert

subjects: Maori, ecosystem-based management, coastal marine estate, sustainability, Treaty of Waitangi

abstract: Ecosystem-based management (EBM) has become an appropriate international response for addressing alarming global environmental degradation trends. EBM is designed and executed as an adaptive, learning-based process that applies the following common international principles:
•	the connections and relationships within an ecosystem;
•	the cumulative impacts that affect marine welfare; 
•	focus on maintaining the natural structure and function of ecosystems and their productivity;
•	incorporate human use and values of ecosystems in managing the resource;
•	recognise that ecosystems are dynamic and constantly changing;
•	are based on a shared vision of all key participants; and
•	are based on scientific knowledge, adopted by continual learning and monitoring.

The New Zealand Sustainable Seas National Science Challenge agrees with these EBM principles but has adapted them into an Aotearoa New Zealand theoretical approach that fundamentally acknowledges mātauranga and tikanga Māori law hence the following Aotearoa New Zealand EBM principles:
•	a co-governance and co-design structure that recognises the Māori constitutional relationship and mana whenua at all levels (whānau, hapū, iwi), together with the guiding principles of mauri, whakapapa, kaitiakitanga, mātauranga-a-iwi and mātauranga-a-hapū;
•	is place and time-specific, recognising/understanding the ecosystem as a whole in all its ecological complexities and connectedness and addressing cumulative and multiple stressors;
•	acknowledges humans as ecosystem components with multiple values;
•	views long-term sustainability as a fundamental value, in particular maintaining values and uses for future generations;
•	includes collaborative and participatory management throughout the whole process, considering all values and involving all interested parties from agencies and iwi to industries, whānau, hapū and local communities;
•	has clear goals and objectives based on knowledge; and
•	includes adaptive management, appropriate monitoring and acknowledgement of uncertainty.

The report focuses on analysing EBM through the incorporation of mātauranga and tikanga Māori and power sharing through Treaty partnerships over the marine and coastal estate.

text: The Treaty, tikanga Māori, ecosystem-based management, mainstream law and power sharing for environmental integrity in Aotearoa New Zealand – possible ways forward Ecosystem-based management (EBM) has become an appropriate international response for addressing alarming global environmental degradation trends. EBM is designed and executed as an adaptive, learning-based process that applies the following common international principles:
•	the connections and relationships within an ecosystem;
•	the cumulative impacts that affect marine welfare; 
•	focus on maintaining the natural structure and function of ecosystems and their productivity;
•	incorporate human use and values of ecosystems in managing the resource;
•	recognise that ecosystems are dynamic and constantly changing;
•	are based on a shared vision of all key participants; and
•	are based on scientific knowledge, adopted by continual learning and monitoring.

The New Zealand Sustainable Seas National Science Challenge agrees with these EBM principles but has adapted them into an Aotearoa New Zealand theoretical approach that fundamentally acknowledges mātauranga and tikanga Māori law hence the following Aotearoa New Zealand EBM principles:
•	a co-governance and co-design structure that recognises the Māori constitutional relationship and mana whenua at all levels (whānau, hapū, iwi), together with the guiding principles of mauri, whakapapa, kaitiakitanga, mātauranga-a-iwi and mātauranga-a-hapū;
•	is place and time-specific, recognising/understanding the ecosystem as a whole in all its ecological complexities and connectedness and addressing cumulative and multiple stressors;
•	acknowledges humans as ecosystem components with multiple values;
•	views long-term sustainability as a fundamental value, in particular maintaining values and uses for future generations;
•	includes collaborative and participatory management throughout the whole process, considering all values and involving all interested parties from agencies and iwi to industries, whānau, hapū and local communities;
•	has clear goals and objectives based on knowledge; and
•	includes adaptive management, appropriate monitoring and acknowledgement of uncertainty.

The report focuses on analysing EBM through the incorporation of mātauranga and tikanga Māori and power sharing through Treaty partnerships over the marine and coastal estate.

year: 2019-07-30